Graeco-Roman polytheism; in Egypt itself however, native religion likely felt little other effects from the new pagan rulers, until the advent of Christianity. Although Augustus built new temples and repaired existing ones in Egypt, Roman religious involvement in the province appears to have peaked here. Later emperors may have done the same on a much smaller scale, but it is evident by the complete lack of involvement after the Nerva-Antonine dynasty that Egyptian religion began to fragment and localise in the wake of the loss of centralisation as in Pharaonic and Ptolemaic Egypt. Where the pagan religion of the Graeco-Roman world accepted the influence and integration of native Egyptian deities and practices into its tradition, Christianity was not nearly as accepting. The strict monotheism of the latter was in stark opposition to the freeform syncretism of paganism. Local Christians engaged in campaigns of proselytism and iconoclasm that contributed even more to the erosion of traditional religion. In AD 333, the number of Egyptian bishops is estimated to be just under 100; the Christianisation of the Roman Empire itself, and edicts by Christian emperors in the third and fourth centuries AD compounded the decline, and the last known inscription in hieroglyphics (regarded by some as a symbol of the decline of the religion itself due to their close ties) dates from AD 394, known as the Graffito of Esmet-Akhom. It is located at the temple of Isis on the island of Philae, in Upper Egypt believed to be one of the final remaining places of worship of native Egyptian religion. By this time, Egyptian religion was largely confined to the south of the country and to the distant, isolated Siwa Oasis in the west. This century also saw significant expansion of institutionalised Christianity into Egypt, but adherence to the old religion on a smaller, more local scale was still prevalent. Philae is also the site of the final demotic inscription, dating to AD 452. The temple was closed in AD 553 by Byzantine emperor Justinian I, who ruled from 527 to 565. As official temples fell into disrepair, and religious structures across Egypt declined, the religion gradually faded away. Though imperial edicts fostered a negative atmosphere towards the pagans, they did not ultimately have a large effect on the disappearance of native religion by themselves. Provincial governors often found that enforcing "anti-pagan" edicts such as those of Theodosius I was incisive,