KIAA1211L is a protein that in humans is encoded by the KIAA1211L gene. It is highly expressed in the brain (Cerebral Cortex). Furthermore, it is localized to the microtubules and the centrosomes and is subcellularly located in the nucleus. Finally, KIAA1211L is associated with certain mental disorders and various cancers. Gene KIAA1211L is a protein-coding gene. The table above presents the gene's alias, location, size and accession number. mRNA There are 11 splice isoforms of the gene KIAA1211L. The validated isoform has 10 exons. Protein The table above presents the protein's alias, size, and accession number. The KIAA1211L protein is proline rich and asparagine, isoleucine, phenylalanine, and tyrosine poor. Domains and motifs The KIAA1211L protein has one domain called the DUF4592 motif and spans amino acids 131–239. This domain is highly conserved among the KIAA1211L orthologs. The DUF4592 motif is depicted in both the conceptual translation and schematic figures. Post translational modifications KIAA1211L is phosphorylated at the Ser92 and Ser490 amino acids. The KIAA1211L protein is also predicted to have five different SUMOylation sites located at Lys134, Lys375, Lys866, Lys874, and Lys914. Both the phosphorylated sites and the SUMOylation sites are depicted in the conceptual translation and schematic figures. Secondary structure The KIAA1211L protein predicted secondary structure is composed of 50% alpha helixes, 8.9% beta sheets, and 17.9% turns. The high number of turns is consistent with the fact that KIAA1211L is proline rich. Subcellular location The KIAA1211L protein is predicted to be located in the nucleus. The orthologs, including the elephant shark, horse, rock dove, and chimp, are also predicted to be located in the nucleus. The nuclear location signal is located on amino acids 25-43 which is depicted in both the conceptual translation and schematic figures. . This signal is conserved throughout the orthologs. Additionally, this location (amino acids 24-43) is positively charged, probably due to the high amount of lysine at this location. Finally, it is predicted that KIAA1211L is mainly localized to the microtubules and centrosome and sometimes localized to the cytokinetic bridge. Expression The gene is highly expressed in the brain (Cerebral Cortex). The KIAA1211L protein is located in many different tissue types, including the brain, the hippocampus, the lung, breast carcinoma, the islets of Langerhans, the pancreas, the kidney, and 38 other tissues. Additionally, it is expressed an average amount compared to other human proteins. Regulation of transcription The promoter region of KIAA1211L is