of immune-suppressive adenosine in the tumor microenvironment, and PEGylated to prolong its circulation in the body. It has been tested in colon, lung, and pancreatic cancer models in preclinical studies. HTI-1511 Anti-EGFR ADC: An antibody-drug conjugate (ADC) with a strong cytotoxin, monomethyl auristatin E, designed to treat EGFR-positive tumors, including those with KRAS and BRAF mutations. It has been tested in colon, lung, and cholangiocarcinoma models in preclinical studies. Clinical trial pipeline Halozyme has many ongoing and completed clinical trials testing the safety and efficacy of its primary investigational drug, PEGPH20, in combination with other therapies, with the goal of finding new treatments for pancreatic cancer, NSCLC, gastric cancer, breast cancer, and others. As of October 2016, the company was sponsoring or collaborating on several clinical trials that were recruiting patients, including: HALO Pancreatic 301 – A Phase 3 study to test the efficacy and safety of a combination of PEGPH20 with Abraxane (nab-paclitaxel) and gemcitabine in participants with previously untreated HA-high stage IV pancreatic cancer. On November 4, 2019, Halozyme announced it has halted development of PEGPH20. HALO Lung / Gastric 101 – A Phase 1b study to test the efficacy and safety of a combination of PEGPH20 and Keytruda (pembrolizumab) in participants with relapsed/refractory advanced or metastatic NSCLC and relapsed/refractory locally advanced or metastatic gastric adenocarcinoma. A Phase 1b study to test the efficacy and safety of a combination of PEGPH20 with Halaven (eribulin) in participants with human epidermal growth factor receptor 2 (HER2)-negative, HA-high metastatic breast cancer (MBC). References External links Biotechnology companies of the United States Companies based in San Diego Pharmaceutical companies established in 1998 2004 initial public offerings Companies listed on the Nasdaq