of medical interventions are supported by 'high quality' evidence according to The Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach. Later meta-research identified widespread difficulty in replicating results in many scientific fields, including psychology and medicine. This problem was termed "the replication crisis". Metascience has grown as a reaction to the replication crisis and to concerns about waste in research. Many prominent publishers are interested in meta-research and in improving the quality of their publications. Top journals such as Science, The Lancet, and Nature, provide ongoing coverage of meta-research and problems with reproducibility. In 2012 PLOS ONE launched a Reproducibility Initiative. In 2015 Biomed Central introduced a minimum-standards-of-reporting checklist to four titles. The first international conference in the broad area of meta-research was the Research Waste/EQUATOR conference held in Edinburgh in 2015; the first international conference on peer review was the Peer Review Congress held in 1989. In 2016, Research Integrity and Peer Review was launched. The journal's opening editorial called for "research that will increase our understanding and suggest potential solutions to issues related to peer review, study reporting, and research and publication ethics". Fields and topics of meta-research Metascience can be categorized into five major areas of interest: Methods, Reporting, Reproducibility, Evaluation, and Incentives. These correspond, respectively, with how to perform, communicate, verify, evaluate, and reward research. Methods Metascience seeks to identify poor research practices, including biases in research, poor study design, abuse of statistics, and to find methods to reduce these practices. Meta-research has identified numerous biases in scientific literature. Of particular note is the widespread misuse of p-values and abuse of statistical significance. Scientific data science Scientific data science is the use of data science to analyse research papers. It encompasses both qualitative and quantitative methods. Research in scientific data science includes fraud detection and citation network analysis. Journalology Journalology, also known as publication science, is the scholarly study of all aspects of the academic publishing process. The field seeks to improve the quality of scholarly research by implementing evidence-based practices in academic publishing. The term "journalology" was coined by Stephen Lock, the former editor-in-chief of The BMJ. The first Peer Review Congress, held in 1989 in Chicago, Illinois, is considered a pivotal moment in the founding of journalology as a distinct field. The field of journalology has been influential in pushing for study pre-registration in science, particularly in clinical trials. Clinical-trial registration is now