times as strong as fentanyl. According to Health Crisis Alert, "Researchers gave monkeys the synthetic opioid carfentanil followed by different doses of naloxone. . . . After receiving naloxone, the monkeys’ brains were observed using Positron Emission Tomography imaging. The higher the level of naloxone, the higher the receptor occupancy." Demographics In the US, addiction and overdoses affect mostly non-Hispanic Whites from the working class. Native Americans and Alaska Natives experienced a five-fold increase in opioid-overdose deaths between 1999 and 2015, with Native Americans having the highest increase of any demographic group. There is significant speculation as to the root causes of the demographic differences, but thus far a credible explanation has yet to be found given the complexity of the issue and the difficulty in controlling for variables when investigating. In 2014, roughly 12 percent of young adults between the ages of 18 and 25 reported abusing prescribed opioids. In 2016, opioid overdoses took the lives of approximately 91 Americans each day. Roughly half of these deaths were caused by prescribed opioids. In 2018, the opioid crisis continued to disproportionately affect non-Hispanic Whites and Native Americans with the National Institutes of Health (NIH) reporting a rise in opioid morbidity and opioid related fatalities. This is especially concerning considering the epidemiology of opioid affliction among white women, who are at a greater risk because they receive more prescription medications than men. According to the NIH (2018), "The opioid epidemic is increasingly young, white, and female" with 1.2million women being diagnosed with an opioid use disorder compared to 0.9million men in 2015. In the United States, those living in rural areas of the country have been the hardest hit. According to Rita Noonan from the CDC, in rural areas, the overall death rate for accidental injuries is 50% higher than in urban areas. Differences in a multitude of factors, such as income, social supports, and accessibility to health care resources, have led to rural communities majorly exceeding urban areas when it comes to the rate of opioid-involved overdose deaths. Non-medical prescription drug use rates have been increasing in teenagers with access to parents' medicine cabinets, especially as 12- to 17-year-old girls were one-third of all new users of prescription drugs in 2006. Teens used prescription drugs more than any illicit drug except cannabis, more than cocaine, heroin, and methamphetamine combined. In 2014, roughly 6 percent of teenagers between the ages of