approximately 1340 base pairs with various predicted transcription factors. The glial cells missing homolog 1 and the oligodendrocyte lineage transcription factors are notable because KIAA1211L is highly expressed in the brain. Furthermore, the Estrogen-related receptor alpha is also a notable transcription factor due to KIAA1211L's low expression levels when estrogen receptors are knocked down. Furthermore, KIAA1211L is predicted to be SUMOylated. The 3' UTR of KIAA1211L is predicted to be a targeted by miRNA-132, which is depicted in the conceptual translation figure. Function Interacting proteins Glycogen Synthase Kinase 3 Beta (GSK3B) GSK3B is a protein kinase that regulates transcription factors and microtubules. As such, it phosphorylates proteins, decreasing their ability to bind and stabilize microtubules. The proteins it phosphorylates are the principle components of neurofibrillary tangles in Alzheimer disease. The protein is needed for the establishment of neuronal polarity and axon outgrowth and phosphorylates proteins in neuroblastoma cells. Furthermore, it is associated with bipolar disease and is active in breast cancer cells. As such, the predicted interaction between KIAA1211L and GSK3B is likely because KIAA1211L is highly expressed in the brain, associated with bipolar disorder and breast cancer, and is localized on the microtubules. The interaction between GSK3B and KIAA1211L was predicted using anti bait coimmunoprecipitation, pull down, tandem affinity purification, fluorescence polarization spectroscopy, protein kinases assay, two hybrid, and confocal microscopy experiments. KIAA1211L protein is also predicted to interact with Alpha-synuclein (SNCA), E3 Ubiquitin-Protein Ligase Mdm2 (MDM2), Serine/Threonine-Protein Kinase PAK 1 (PAK 1), and DNA Replication Factor Cdt1 (CDT1). Clinical significance KIAA1211L is associated with depression, bipolar disorder, and schizophrenia. Additionally, KIAA1211L is associated with various cancers including ovarian, breast, etc. Homology Paralogs KIAA1211 is the paralog to KIAA1211L. KIAA1211 is located on chromosome 4 and has 1233 amino acids. Its percent identity to KIAA1211L is 21%. The KIAA1211 has an ortholog in the bacteria Proteus vulgarism, indicating the paralog duplicated 4290 million years ago, before KIAA1211L. Orthologs Below is the table of various KIAA1211L orthologs. It includes closely, intermediately, and distantly related orthologs. The most distant ortholog is the elephant shark, indicating KIAA1211L duplicated 473 MYA. The amino acids conserved among all the KIAA1211L orthologs are depicted in the conceptual translation. Phylogeny The KIAA1211L gene is similar and conserved in mammals, birds, reptiles, amphibians, and fish. It is not conserved in bacteria, archaea, protists, plants, fungus, trichoplax, and invertebrates. Citations Human proteins