the second round. He later beat 8th seed John Millman in 70 minutes to move into his first career ATP tour-level semifinal, where he lost to second seed Gaël Monfils. As a result, he reached a new career-high ranking in the top 60, at world No. 59 on October 4, 2021. 2022: Top 50 debut & Maiden tour final Giron started his 2022 season at the first edition of the Melbourne Summer Set 1. He lost in the first round to qualifier Ričardas Berankis. At the Sydney Classic, he was defeated in the first round by Australian wildcard Jordan Thompson. Ranked 66 at the Australian Open, he was beaten in the first round by 6th seed and eventual champion, Rafael Nadal. Seeded 7th at the first edition of the Dallas Open, Giron upset top seed, world No. 19, and compatriot, Taylor Fritz, in the quarterfinals to reach his second ATP tour semifinal. He lost in his semifinal match to 4th seed and compatriot, Jenson Brooksby, in three sets, despite holding four match points. In Delray Beach, he was defeated in the second round by John Millman. At the Abierto Mexicano Telcel in Acapulco, he beat eighth seed and world No. 17, Pablo Carreño Busta, in the second round. He lost in the quarterfinals to third seed, world No. 4, and last year finalist, Stefanos Tsitsipas. At the Indian Wells Masters, he was eliminated in the first round by Lorenzo Musetti. In Miami, he lost in the first round to Márton Fucsovics. Giron started his clay-court season at the U.S. Men's Clay Court Championships in Houston, Texas. He lost in the first round to sixth seed and compatriot, Frances Tiafoe. At the Monte-Carlo Masters, he was defeated in the first round by eventual finalist Alejandro Davidovich Fokina. In Barcelona, he lost in the first round to Federico Coria. At the BMW Open in Munich, he fell in the first round to Hugo Gaston. At the Madrid Open, he was beaten in the first round of qualifying by Alejandro Tabilo. On his debut at the Italian Open as a lucky loser, he upset 12th seed, world No. 15, and 2020 finalist, Diego Schwartzman, in the second round. He lost in the third round to eighth seed and world No. 9, Félix Auger-Aliassime. In Geneva, he lost in the first round to Ilya Ivashka. He made his top 50 debut on 16 May