"The Isolation Permutation" is the eighth episode of the fifth season of the US sitcom The Big Bang Theory and the 95th episode of the show overall. It first aired on CBS on November 3, 2011. In the episode, Amy becomes upset when Penny and Bernadette go dress shopping without her. Plot Bernadette and Penny are shopping for bridesmaid dresses; Howard inadvertently mentions this in front of Amy, who is upset that they did not invite her. Sheldon is unable to contact Amy: she does not answer Facebook messages, video chats or any other form of communication Sheldon tries to use. He and Leonard go round to her house and finds her singing "Everybody Hurts" while playing the harp. Leonard knocks on the door and leaves, leaving Sheldon alone with Amy. She wants physical intimacy with Sheldon and after negotiating, Sheldon reluctantly cuddles with her. The following day, Sheldon angrily confronts Howard and Leonard, telling them to "get [their] women in line". They talk to Penny and Bernadette, who explain that Amy is over-enthusiastic about being a bridesmaid. Penny and Bernadette apologize to Amy, but Amy is still upset. She makes an analogy involving a brain's hemispheres, comparing Bernadette to the left hemisphere, Penny to the right hemisphere and herself to a brain tumour. Later, Sheldon receives a phone call telling him that Amy is drunk in a parking lot. He and Leonard go and take her home. The next morning, Penny and Bernadette apologize again and offer Amy the chance to be the maid of honor at Bernadette's wedding. She is very excited about this. In the final scene, Amy records the three of them dress shopping. Reception Ratings On the night of its first broadcast in the US on November 3, 2011 at 8 p.m., the episode received 15.98 million viewers on CBS, and a 5.4/16 Nielsen rating. It beat the other shows in its timeslot: The X Factor received 11.64 million views on Fox; Community was watched by 3.84 million on NBC; The Vampire Diaries got 3.51 million viewers on The CW and 5.31 households watched Charlie's Angels on ABC. On CBS, the episode was most watched that night. At 8:30 p.m., Rules of Engagement received 11.81 million views; Grey's Anatomy was watched by 9.52 million at 9 p.m. and The Mentalist garnered 13.66 million viewers at 10 p.m. In Canada, the episode aired at the same