a dynamic programming algorithm to recognize the membrane topology models by maximizing the expectation. Since MEMSAT was originally built back in 1994, it then triggered a lot of improvements in the prediction of secondary structure. The newest version is MEMSAT3, released in 2007. It uses a neural network to determine the locations of residues are on the cytoplasmic side of the membrane or in the transmembrane helices. CATH database Jones was involved in the early stage of development of the CATH database, with Christine Orengo and Janet Thornton which is a hierarchical domain classification of protein structures in the Protein Data Bank, where the 4 major levels in hierarchy are: Class, Architecture, Topology, and Homologous superfamily. The CATH database employs a combination of automatic and manual techniques. GenTHREADER GenTHREADER is a faster and more powerful tool for protein fold recognition, that can be applied to either whole/individual protein sequences. The method uses a traditional sequence alignment algorithm to generate alignments, and then the alignment will be evaluated by threading techniques. As the last step, each model will be evaluated by a neural network to produce a measurement of the confidence level in the proposed prediction. The emergence of GenTHREADER has enabled a series of improvement work. So far, there are several improved methods available now: mGenTHREADER, pDomTHREADER, and pGenTHREADER. PSIPRED This is a server that aggregates several structure prediction methods. It includes the newly implemented method also known as PSIPRED (Predict Secondary Protein Structure), a technique for protein secondary structure prediction, and the other techniques Predict Transmembrane Topology (MEMSAT3), and Fold Recognition (GenTHREADER). Users submit a protein sequence, perform any prediction of interest, and receive the results by e-mail. Academic service Since 1996, Jones has been involved in many research committees, including: Biotechnology and Biological Sciences Research Council (BBSRC), Engineering and Physical Sciences Research Council (EPSRC), Medical Research Council (MRC), and Research Councils UK. His research has been funded by the BBSRC, The Wellcome Trust, Elsevier, the EPSRC, the MRC, The Royal Society, The European Commission, AstraZeneca, GlaxoSmithKline and Sun Microsystems. Awards and honours Jones held a prestigious Royal Society University Research Fellowship from 1995 to 1999. In 2022, Jones was elected as a Fellow of the International Society for Computational Biology. References Living people British bioinformaticians Academics of University College London 20th-century British biologists 21st-century British biologists 1966 births