• Methylenedioxybenzylpiperazine (MDBZP, piperonylpiperazine) Others: 2-Amino-1,2-dihydronaphthalene (2-ADN) • 2-Aminoindane (2-AI) • 2-Aminotetralin (2-AT) • 4-Benzylpiperidine (4-BP) • 5-Iodo-2-aminoindane (5-IAI) • Clofenciclan • Cyclopentamine • Cypenamine • Cyprodenate • Feprosidnine • Gilutensin • Heptaminol • Hexacyclonate • Indanylaminopropane (IAP) • Indanorex • Isometheptene • Methylhexanamine • Naphthylaminopropane (NAP) • Octodrine • Phthalimidopropiophenone • Propylhexedrine (levopropylhexedrine) • Tuaminoheptane (tuamine) Enzyme inhibitors Synthesis inhibitors Phenylalanine hydroxylase inhibitors 3,4-Dihydroxystyrene Tyrosine hydroxylase inhibitors 3-Iodotyrosine • Aquayamycin • Bulbocapnine • Metirosine • Oudenone Aromatic L-amino acid decarboxylase inhibitors (DOPA decarboxylase inhibitors) Benserazide • Carbidopa • Genistein • Methyldopa Degradation inhibitors Monoamine oxidase (MAO) inhibitors Nonselective: Benmoxin • Caroxazone • Echinopsidine • Furazolidone • Hydralazine • Indantadol • Iproclozide • Iproniazid • Isocarboxazid • Isoniazid • Linezolid • Mebanazine • Metfendrazine • Nialamide • Octamoxin • Paraxazone • Phenelzine • Pheniprazine • Phenoxypropazine • Pivalylbenzhydrazine • Procarbazine • Safrazine • Tranylcypromine MAO-A selective: Amiflamine • Bazinaprine • Befloxatone • Befol • Brofaromine • Cimoxatone • Clorgiline • Esuprone • Harmala alkaloids (harmine, harmaline, tetrahydroharmine, harman, norharman, etc.) • Methylene blue • Metralindole • Minaprine • Moclobemide • Pirlindole • Sercloremine • Tetrindole • Toloxatone • Tyrima MAO-B selective: D-Deprenyl • Selegiline (L-deprenyl) • Ladostigil • Lazabemide • Milacemide • Mofegiline • Pargyline • Rasagiline • Safinamide Catechol-O-methyl transferase (COMT) inhibitors Entacapone • Nitecapone • Opicapone • Tolcapone Dopamine beta hydroxylase inhibitors Bupicomide • Disulfiram • Dopastin • Fusaric acid • Nepicastat • Phenopicolinic acid • Tropolone Others Precursors L-Phenylalanine → L-tyrosine → L-DOPA (levodopa) Cofactors Ferrous iron (Fe2+) • Tetrahydrobiopterin • Vitamin B3 (niacin, nicotinamide → NADPH) • Vitamin B6 (pyridoxine, pyridoxamine, pyridoxal → pyridoxal phosphate) • Vitamin B9 (folic acid → tetrahydrofolic acid) • Vitamin C (ascorbic acid) • Zinc (Zn2+) Activity enhancers Benzofuranylpropylaminopentane (BPAP) • Phenylpropylaminopentane (PPAP) • Selegiline (L-deprenyl) Toxins Oxidopamine (6-hydroxydopamine) Levodopa prodrugs XP21279 Photoswitchable ligands A photoswitchable agonist of D1-like receptors (azodopa) has been described that allows reversible control of dopaminergic transmission in wildtype animals. References Dopaminergics