In chemistry, reaction progress kinetic analysis (RPKA) is a subset of a broad range of kinetic techniques utilized to determine the rate laws of chemical reactions and to aid in elucidation of reaction mechanisms. While the concepts guiding reaction progress kinetic analysis are not new, the process was formalized by Professor Donna Blackmond (currently at Scripps Research Institute) in the late 1990s and has since seen increasingly widespread use. Unlike more common pseudo-first-order analysis, in which an overwhelming excess of one or more reagents is used relative to a species of interest, RPKA probes reactions at synthetically relevant conditions (i.e. with concentrations and reagent ratios resembling those used in the reaction when not exploring the rate law.) Generally, this analysis involves a system in which the concentrations of multiple reactants are changing measurably over the course of the reaction. As the mechanism can vary depending on the relative and absolute concentrations of the species involved, this approach obtains results that are much more representative of reaction behavior under commonly utilized conditions than do traditional tactics. Furthermore, information obtained by observation of the reaction over time may provide insight regarding unexpected behavior such as induction periods, catalyst deactivation, or changes in mechanism. Monitoring reaction progress Reaction progress kinetic analysis relies on the ability to accurately monitor the reaction conversion over time. This goal may be accomplished by a range of techniques, the most common of which are described below. While these techniques are sometimes categorized as differential (monitoring reaction rate over time) or integral (monitoring the amount of substrate and/or product over time), simple mathematical manipulation (differentiation or integration) allows interconversion of the data obtained by either of the two. Regardless of the technique implemented, it is generally advantageous to confirm the validity in the system of interest by monitoring with an additional independent method. Reaction progress NMR NMR spectroscopy is often the method of choice for monitoring reaction progress, where substrate consumption and/or product formation may be observed over time from the change of peak integration relative to a non-reactive standard. From the concentration data, the rate of reaction over time may be obtained by taking the derivative of a polynomial fit to the experimental curve. Reaction progress NMR may be classified as an integral technique as the primary data collected are proportional to concentration vs. time. While this technique is extremely convenient for clearly defined systems with distinctive, isolated