fluorescence microscopy and fast temperature jump or osmotic pressure jump to study protein dynamics inside living cells and living animals. A sub-microsecond pressure jump technique to study fast protein refolding and helpe guide computer simulations (molecular dynamics) for how proteins fold. With Martina Havenith, Terahertz Absorption Spectroscopy elucidating the role of long-range interactions of water with biomolecules. Two-state dynamics recorded on glass surfaces using time-resolved Scanning Tunneling Microscopy, to measure the size and heterogeneous dynamics of cooperatively rearranging regions on a glass. SMA-STM (Single Molecule Absorption detected by Scanning Tunneling Microscopy), a technique that can image excited state orbitals of nanostructures with sub-nanometer position resolution and sub-picosecond time resolution. With Stephen Boppart, non-linear interferometric vibrational imaging which produces easy-to-read, color-coded images of tissue, outlining clear tumor boundaries with more than 99% confidence. Computational and theoretical work in the area of quantum energy flow, quantum computation, and quantum information, as well as fundamental transport theory and computation. Awards Gruebele is a Member of the National Academy of Sciences (2013), a Member of the American Academy of Arts and Sciences (2010), and a Member of the German Academy of Sciences Leopoldina (2008). He is a Fellow of the American Chemical Society (2015), American Physical Society (2002), and the Biophysical Society (2005). Gruebele has received national and international awards, such as the Hans Neurath Award of the Protein Society, the Nakanishi Prize, the Raymond and Beverly Sackler Prize in the Physical Sciences (Tel Aviv University, 2008), the Friedrich Wilhelm Bessel Prize (Alexander von Humboldt Foundation, 2005), and the Coblentz Award (Coblentz Society, 2000). He was also awarded an Alfred P. Sloan Fellowship (1997), a Cottrell Scholar Award from the Research Corporation (1995), the Camille and Henry Dreyfus Fellowship (1998, 1992), a David and Lucile Packard Fellowship (Packard Foundation, 1994), a National Young Investigator Award (NSF, 1994), and a Beckman Fellowship, 1995–1996. Gruebele collaborated with Hanoi University of Science to port the University of Illinois Department of Chemistry undergraduate curriculum for Chemistry to Vietnam. He has been on the list of "Teachers Ranked Excellent by their Students" at Illinois multiple times (most recently 2022), and received the School of Chemical Sciences Teaching Excellence Award. He is a contributor to LibreTexts, which makes open-access textbooks available to students. Personal Gruebele is married to Nancy Makri, who is also a Professor of Chemistry and Physics at University of Illinois at Urbana-Champaign. They have two children, Alexander