century were quoted, referenced and alluded to as authoritative by bishops who were allegedly directly appointed by the apostles in the first century; namely Clement of Rome, Ignatius of Antioch and Polycarp. Irenaeus (died ) quotes and cites 21 books that would end up as part of the New Testament, but does not use Philemon, Hebrews, James, 2 Peter, 3 John and Jude. By the early 3rd century, Origen of Alexandria may have been using the same 27 books as in the modern New Testament, though there were still disputes over the canonicity of Hebrews, James, 2 Peter, 2 and 3 John, and Revelation (see also Antilegomena). Likewise by 200, the Muratorian fragment shows that there existed a set of Christian writings somewhat similar to what is now the New Testament, which included four gospels and argued against objections to them. Thus, while there was plenty of discussion in the Early Church over the New Testament canon, the "major" writings were accepted by almost all Christian authorities by the middle of the second century. The next two hundred years followed a similar process of continual discussion throughout the entire Church, and localized refinements of acceptance. This process was not yet complete at the time of the First Council of Nicaea in 325, though substantial progress had been made by then. Though a list was clearly necessary to fulfill Constantine's commission in 331 of fifty copies of the Bible for the Church at Constantinople, no concrete evidence exists to indicate that it was considered to be a formal canon. In the absence of a canonical list, the resolution of questions would normally have been directed through the see of Constantinople, in consultation with Bishop Eusebius of Caesarea (who was given the commission), and perhaps other bishops who were available locally. In his Easter letter of 367, Athanasius, Bishop of Alexandria, gave a list of exactly the same books that would formally become the New Testament canon, and he used the word "canonized" () in regard to them. The first council that accepted the present Catholic canon (the Canon of Trent) was the Council of Rome, held by Pope Damasus I (382). A second council was held at the Synod of Hippo (393) reaffirming the previous council list. A brief summary of the acts was read at and accepted by the Council of Carthage (397) and the Council of Carthage (419). These