between the so-called Old State, i.e. Florence, and the New State, i.e. Siena and the southern part up to Pitigliano, with different laws and taxes. With the death of Gian Gastone de' Medici, (1737), who had no children, the Medici dynasty ended and the Grand Duchy passed into the hands of the Habsburg-Lorraine dynasty who kept it until 1799. Late modern period After the Napoleonic period and the Risorgimento uprisings, Siena was the first city in Tuscany, in 1859, to vote in favour of annexation to the Kingdom of Italy. Geography Siena is located in the central part of Tuscany, in the middle of a vast hilly landscape between the Arbia river valley (south), the Merse valley (south-west), the Elsa valley (north), the Chianti hills (north-east), the Montagnola Senese (west) and the Crete Senesi (south-east). The city lies at above sea level. Climate Siena has a typical inland Mediterranean climate. Average rainfall is , with the maximum in November and the minimum in July. July is the hottest month, with an average temperature of , and January the coldest. Economy The main activities are tourism, services, agriculture, handicrafts and light industry. In 2009 agricultural activity comprised 919 companies with a total area of for a usable agricultural area of or about of the total municipal area (data ISTAT for the 2000 Agriculture Census V). There is little manufacturing in the city. One exception is the seasonal confectionery industry, which produces local specialities including panforte, ricciarelli and cavallucci at Christmas, and pane co' santi for I Santi on 1 November and I Morti on the following day. The area has also seen a growth in biotechnology. The Centenary Institute Sieroterapico Achille Sclavo used to be Swiss-owned, operating under the company name, Novartis Vaccines. Novartis developed and produced vaccines and employed about a thousand people. In 2015, the research plant in Siena became part of Glaxo Smith Kline, as part of a deal between Novartis and this firm. Government Culture Contrade Siena retains a ward-centric culture from medieval times. Each ward (contrada) is represented by an animal or mascot and has its own boundary and distinct identity. Ward rivalries are most rampant during the annual horse race (Palio) in the Piazza del Campo. There are 17 wards (contrada): Aquila, Bruco, Chiocciola, Civetta, Drago, Giraffa, Istrice, Leocorno, Lupa, Nicchio, Oca, Onda, Pantera, Selva, Tartuca, Torre, Valdimontone. The Palio The Palio di Siena is