is amphipathic but does not have a lipid group, so there are few skin toxicity problems due to lipid peroxidation, and it does not have the sticky feeling of conventional vitamin C derivatives and has a good feel. Stability When the aqueous solution containing vitamin C and GO-VC was stored at 50 °C for 90 days, the vitamin C residual amount decreased to less than 30% in 30 days, whereas the residual amount of GO-VC was 90% or more. Moreover, after 90 days, 80% or more of GO-VC was confirmed to remain. It is considered that these high stability are due to the two most reactive hydroxyl groups of vitamin C being capped by glycerin and octanol at the same time. Because the viscosity is stable in the preparation containing GO-VC and the polymer gel too, and it can be kept in a transparent state for a long period of time. Therefore, GO-VC can be added to many preparations such as lotions, creams, serums and gels. Acne It was reported that GO-VC is effective against post-inflammatory hyperpigmentation (PIH), post-inflammatory erythema (PIE), and atrophic scar (AS), which are important complications in acne. It applied a complex vitamin C derivative lotion containing GO-VC to each of 10 patients with acne twice on the right side twice a day for 3 months, and confirmed the left side without application and its effect. It was reported that there was a marked improvement in PIH, PIE, and AS on the only right side applying lotion containing GO-VC after 3 months. Pigmentation Many phenolic compounds, which are conventional whitening agents, react with tyrosinase to induce melanocyte-specific cytotoxicity, and thus there was a risk of developing vitiligo. GO-VC reduced the intracellular melanin content of B16 melanoma cells. GO-VC's pigmentation inhibitory mechanism is shown to act through a novel melanogenesis inhibitory system that does not depend on tyrosinase activity inhibition, indicating that it is a safe and effective pigmentation inhibitor with low risk of vitiligo. GO-VC showed a remarkable effect in an actual pigmentation suppression clinical study, and a gel preparation containing 0.1% GO-VC was applied twice a day in the morning and evening on the entire face after 13 female subjects aged 39.8 years on average. As a result of a 1-5 month study, GO-VC significantly improved post-inflammatory pigmentation. It is reported that GO-VC also showed a clear improvement in pigmentation caused by metal allergy, which was