Glyceryl octyl ascorbic acid (GO-VC) is an amphipathic derivative of vitamin C consisting of two ether linkages: a 1-octyl at position 2 and a glycerin at position 3. The chemical name is 2-glyceryl-3-octyl ascorbic acid. The isomer in which these two groups are swapped (2-octyl-3-glyceryl ascorbic acid, OG-VC) is also known. It is considered as a new stable amphipathic in the field of aesthetic medicine. Overview Vitamin C is rapidly converted to ascorbic acid radicals by UV rays, which causes cytotoxicity and sunburn, but GO-VC improves the stability of conventional vitamin C derivatives, and thus eliminates the problems of these prooxidants. Water-soluble vitamin C derivatives, such as sodium ascorbyl phosphate (APS), which have been used since the 1990s, have a problem of drying the skin in order to the sebum suppression effect. On the other hand, GO-VC has a high moisturizing power due to the binding of glycerin and can prevent the dryness of the skin. In addition, GO-VC has a sterilizing activity of octanol, so it has a sterilizing activity against many bacteria. GO-VC is also used for wound healing and wrinkle prevention because it has a proliferative effect on fibroblasts and a promoting effect on type I collagen production. GO-VC has a stronger melanin production inhibitory effect than arbutin, which is used as a whitening agent, and it was confirmed in clinical trials that even low concentrations of 0.01 to 0.1% (by weight) are effective against acne redness and pigmentation. The water-soluble vitamin C derivatives such as ascorbic acid 2-glucoside and APPS (trisodium ascorbyl palmitate) can not add to water-soluble polymer gels commonly used in cosmetics such as carboxy vinyl polymer and sodium polyacrylate. This is because the viscosity changes, causing precipitation. On the other hand, GO-VC can be dispersed in water-soluble polymer gel transparently and uniformly or can be stably dissolved for a long time. The fat-soluble vitamin C derivatives such as ascorbyl tetrahexyl decanoate (VC-IP) are almost insoluble in water, making it difficult to mix in water-soluble formulations such as lotions without the use of surfactants. Fat-soluble vitamin C derivatives causes lipid oxidation problems when lipids are released, and the color of the formulation tends to change. GO-VC can solve these problems almost completely. GO-VC is well absorbed percutaneously due to its amphiphilic nature, and because it is negatively charged rather than completely non-ionic, it can facilitate percutaneous absorption with an iontophoresis device. In addition, GO-VC