Senator Santiago may refer to: Carmelo Ríos Santiago (born 1973), Senate of Puerto Rico Margarita Nolasco Santiago (fl. 1990s–2010s), Senate of Puerto Rico María de Lourdes Santiago (born 1968), Senate of Puerto Rico Nellie R. Santiago (born 1943), New York State Senate Nelson Cruz Santiago (born 1975), Senate of Puerto Rico Rafael Picó Santiago (1912–1998), Senate of Puerto Rico