mutant of p53 being edited using arRNA151 to achieve a "normal" p53 translation and functional p53-mediated transcriptional responses. Comparison to CRISPR LEAPER is analogous to CRISPR Cas-13 in that it targets RNA before proteins are synthesized. However, LEAPER is simpler and more efficient as it only requires , rather than Cas and a guide RNA. According to the researchers who developed LEAPER, it has the potential to be easier and more precise than any CRISPR technique. LEAPER also eliminates health concerns and technical barriers arising from the introduction of exogenous proteins. It has also been called more ethical as it does not change DNA and thus does not result in heritable changes, unlike methods using CRISPR Cas-9. See also CRISPR gene editing Gene knockout NgAgo Prime editing References Genetic engineering Genome editing Biotechnology RNA Biochemistry