The paleoethnobotany of the Mapuche focuses on archaeological evidence supporting plant use by past and present Mapuche populations collected from multiple sites in southern Chile and the Patagonia region of Argentina. Paleoethnobotany is the study of fossil and material remains from plants, mostly seeds and residues that can be analyzed from material remains. Data can be collected from archaeological sites with a particular interest in learning about the history of agriculture in a region or the use of plants for either subsistence or medicinal use. The Mapuche are an indigenous culture native to South America. The archaeological record has revealed that the Mapuche were present in modern-day south-central Chile and southwestern Argentina from at least 500-600 BC. It is also noteworthy, that while collectively the Mapuche (Picunche, Huilliche and Moluche or Nguluche) use this endonym, there are often subsets of the culture that have more specific names based on geographic location as well as different ecological niches (See Mapuche: Etymology). Regional sites in South America Central and Southern Chile Cerro del Inga The Promaucaes, a Mapuche group, were the last group of indigenous peoples to occupy this site in modern-day Chile in the Cachapoal Valley. Archeobotanical analysis was conducted at these sites in relation to pre-Hispanic cultures dominated by the Incan civilization. This site serves as a point of resistance to both Incan occupation as well as Spanish colonization. Analysis of seeds and macromaterials from soil reveal the following plants were present at this site. Culitivated plants included: Maize (Zea mays), Madi (Madia chilensis), Quinoa (Chenopodium quinua), Sunflower (Helianthus sp. cf. tuberosum), Gourd (Lagenaria sp.). Fruiting bushes and trees included: Guillave (Echinopsis chilensis) Michay (Berberis sp.), Boldo (Peumus boldus), Quilo (Muehlenbeckia hastulata) Grape (Vitis sp.), Blackberry (Rubus sp.), Cocito, Palm Nut (Jubaea chilensis). Legumes included: Unidentified, small (Astragalus sp.?) Unidentified, large, Lupine (Lupinus sp.). Medicinal herbs included: Pata de Guanaco (Calandrinia grandiflora) along with some wilds plants: Various Grasses (Poaceae), Colliguay (Colliguaja odifera), Espino (Acacia caven), Lengua de Gato (Galium sp.), Sedge (Cyperus sp.), and Chenopod (Chenopodium sp.). Central and Southern Argentina La Pampa There are a series of 5 sites (1,3,5, La Lomita) located in the La Pampa region of Argentina that demonstrate the historical presence of pre-Hispanic hunter-gatherers and farming cultures in west-central Argentina in the period of the Upper Holocene to the Lower Holocene. Food residues were analyzed from 23 sherds from pottery obtained from these sites.