|- style="background:#cfc;" | 32 || 20 || 7:00 pm || Florida Panthers || 1–3 || Pittsburgh Penguins || Consol Energy Center (18,668) || 22–6–4 || 48 |- style="background:#ffc;" | 33 || 22 || 7:30 pm || Pittsburgh Penguins || 3–4 SO || Florida Panthers || BB&T Center (15,947) || 22–6–5 || 49 |- style="background:#fcf;" | 34 || 23 || 7:30 pm || Pittsburgh Penguins || 3–4 || Tampa Bay Lightning || Tampa Bay Times Forum (19,204) || 22–7–5 || 49 |- style="background:#fcf;" | 35 || 27 || 7:00 pm || Washington Capitals || 3–0 || Pittsburgh Penguins || Consol Energy Center (18,663) || 22–8–5 || 49 |- style="background:#fcf;" | 36 || 29 || 7:00 pm || Pittsburgh Penguins || 1–3 || New Jersey Devils || Prudential Center (16,592) || 22–9–5 || 49 |- style="background:#cfc;" | 37 || 31 || 7:00 pm || Carolina Hurricanes || 1–2 || Pittsburgh Penguins || Consol Energy Center (18,639) || 23–9–5 || 51 |- |- style="background:#cfc;" | 38 || 2 || 7:00 pm || Tampa Bay Lightning || 3–6 || Pittsburgh Penguins || Consol Energy Center (18,655) || 24–9–5 || 53 |- style="background:#fcf;" | 39 || 3 || 7:00 pm || Montreal Canadiens || 4–1 || Pittsburgh Penguins || Consol Energy Center (18,630) || 24–10–5 || 53 |- style="background:#ffc;" | 40 || 7 || 8:00 pm || Boston Bruins || 3–2 OT || Pittsburgh Penguins || Consol Energy Center (18,650) || 24–10–6 || 54 |- style="background:#cfc;" | 41 || 10 || 7:00 pm || Pittsburgh Penguins || 2–1 OT || Montreal Canadiens || Bell Centre (21,287) || 25–10–6 || 56 |- style="background:#cfc;" | 42 || 13 || 7:00 pm || Minnesota Wild || 2–7 || Pittsburgh Penguins || Consol Energy Center (18,642) || 26–10–6 || 58 |- style="background:#fcf;" | 43 || 16 || 7:00 pm || Pittsburgh Penguins || 3–6 || New York Islanders || Nassau Coliseum (16,170) || 26–11–6 || 58 |- style="background:#fcf;" | 44 || 18 || 12:30 pm || New York Rangers || 5–2 || Pittsburgh Penguins || Consol Energy Center (18,687) || 26–12–6 || 58 |- style="background:#ffc;" | 45 || 20 || 7:00 pm || Pittsburgh Penguins || 2–3 OT || Philadelphia Flyers || Wells Fargo Center (19,982) || 26–12–7 || 59 |- style="background:#ffc;" | 46 || 21 || 8:00 pm || Chicago Blackhawks || 2–3 SO || Pittsburgh Penguins || Consol Energy Center (18,655) || 26–12–8 || 60 |- style="background:#cfc;"