13 combined tackles and deflected a pass as the Ravens routed the Browns 28–7. In Week 17, Kirksey recorded 12 combined tackles and sacked Ben Roethlisberger, for his third time in his career, during a 27–24 loss at the Pittsburgh Steelers. Kirksey had an impressive season in 2016 and led the Browns with 148 combined tackles (96 solo), 2.5 sacks, and three pass deflections in 16 games and 16 starts. 2017 On May 30, 2017, the Cleveland Browns signed Kirksey to a four-year, $38 million contract extension that includes $20 million guaranteed and a signing bonus of $6 million. Former Cleveland Browns' defensive coordinator Ray Horton was fired after the 2016 season and replaced by Gregg Williams who switched the base defense from a 3-4 defense to a 4-3 defense. Kirksey was moved from starting inside linebacker to starting weakside linebacker. During a Week 2 matchup at the Baltimore Ravens, Kirksey made nine combined tackles and sacked Joe Flacco as the Browns lost 24–10. On October 22, 2017, he recorded a career-high 17 combined tackles during a 12–9 loss to the Tennessee Titans. On November 19, 2017, Kirksey collected 14 combined tackles and sacked Jacksonville Jaguars' quarterback Blake Bortles in a 19–7 loss. He finished the season with 136 combined tackles (86 solo), five pass deflections, and 3.5 sacks in 16 games and 16 starts. His 138 tackles finished second in the team, behind Joe Schobert's 144. Pro Football Focus gave Kirksey an overall grade of 59.6, ranking 52nd among all qualified linebackers in 2017. 2018 On October 7, 2018, Kirksey recorded a season-high 12 tackles against the Baltimore Ravens. On October 14, Kirksey intercepted Los Angeles Chargers' Philip Rivers, his first-career interception. The very next week he would pick off Tampa Bay Buccaneers' quarterback Jameis Winston and recover a Cameron Brate fumble on October 21, 2018, marking his second-career interception and third-career fumble recovery. On November 7, he was placed on injured reserve with a hamstring injury. 2019 On September 21, 2019, Kirksey was placed on injured reserve with a chest injury. On March 10, 2020, Kirksey was released by the Browns after six seasons. Green Bay Packers On March 17, 2020, Kirksey signed a two-year, $16 million contract with the Green Bay Packers. Kirksey made his debut with the Packers in Week 1 against the Minnesota Vikings. During the game, Kirksey led the team with 12 tackles (6