KIAA1841 is a gene in humans that encodes a protein known as KIAA1841 (uncharacterized protein KIAA1841). KIAA1841 is targeted for the nucleus and it predicted to play a role in regulating transcription. Gene Location KIAA1841 is located on the long arm of chromosome 2 (2q14), starting at 61297486 and ending at 61349294. The KIAA1841 gene spans 52809 base pairs and is orientated on the ++ strand. The coding region is made up of 4292 base pairs and the protein sequence of 718 amino acids. Gene neighborhood Genes PEX13 and C2orf74 neighbor KIAA1841 on chromosome 2. Expression KIAA1841 is highly expressed in reproductive structures and nervous tissue. These include the brain, prostate, cervix, ear and nervous tissue. It is intermediately expressed in the lungs and spinal cord. KIAA1841 is expressed at low levels in a wide range of tissues throughout the human body. Transcript variants In humans, the KIAA1841 gene produces 18 alternatively spliced transcript variants as well as 3 unspliced. From the 18 spliced variants 4 form a protein product. The main transcript in humans is transcript ID ENST00000402291, or OTTHUMT00000325477. Homology Paralogs There are no paralogs of KIAA1841 Orthologs Below is a table of a variety of orthologs of the human KIAA1841. The table include closely, intermediately and distantly related orthologs. Orthologs of the human protein KIAA1841 are listed above in descending order or date of divergence and then ascending order of percent identity. KIAA1841 is highly conserved throughout all orthologs, this is demonstrated with a 40% identity in the least similar ortholog. KAA1841 has evolved slowly and evenly over time. Homologous domains The domain of unknown function 3342 is conserved in all orthologs. It is the highest conserved region of the protein. Conservation of this domain was traced all the way back to a fungus called Batrachochytrium dendrobatidis, which diverged 1216 million years ago from humans. Protein General properties The molecular weight of KIAA1841 is 82 kiloDaltons. The isoelectric point is 6.5. The protein sequence is not rich or low in any amino acids. There are two stretches of non-polar regions, which are capable of being transmembrane regions. There is a stretch of 21 0’s from 254-275 and a stretch of 24 0’s from 420–444.1 The DUF3342 domain stretches from 147–449. Composition There is an even distribution of amino acids comprising KIAA1841. The percent composition of each amino acid is fairly consistent throughout the orthologs of the protein.