of Edessa, and the renowned hospital and medical academy of Jundishapur; libraries included the Library of Alexandria and the Imperial Library of Constantinople; other centers of translation and learning functioned at Merv, Salonika, Nishapur and Ctesiphon, situated just south of what later became Baghdad. The House of Wisdom was a library, translation institute, and academy established in Abbasid-era Baghdad, Iraq. Nestorians played a prominent role in the formation of Arab culture, with the Jundishapur school being prominent in the late Sassanid, Umayyad and early Abbasid periods. Notably, eight generations of the Nestorian Bukhtishu family served as private doctors to caliphs and sultans between the 8th and 11th centuries. The Byzantine science played an important role in the transmission of classical knowledge to the Islamic world and to Renaissance Italy, and also in the transmission of Islamic science to Renaissance Italy. Many of the most distinguished classical scholars held high office in the Eastern Orthodox Church. The migration waves of Byzantine scholars and émigrés in the period following the Crusader sacking of Constantinople in 1204 and the end of the Byzantine Empire in 1453, is considered by many scholars key to the revival of Greek and Roman studies that led to the development of the Renaissance humanism and science. These émigrés brought to Western Europe the relatively well-preserved remnants and accumulated knowledge of their own (Greek) civilization, which had mostly not survived the Early Middle Ages in the West. According to the Encyclopædia Britannica: "Many modern scholars also agree that the exodus of Greeks to Italy as a result of this event marked the end of the Middle Ages and the beginning of the Renaissance". Modern reception Individual scientists' views Christian Scholars and Scientists have made noted contributions to science and technology fields, as well as Medicine, both historically and in modern times. Many well-known historical figures who influenced Western science considered themselves Christian such as Nicolaus Copernicus, Galileo Galilei, Johannes Kepler, Isaac Newton Robert Boyle, Francis Bacon, Gottfried Wilhelm Leibniz, Carl Friedrich Gauss, Emanuel Swedenborg, Alessandro Volta, Carl Friedrich Gauss, Antoine Lavoisier, André-Marie Ampère, John Dalton, James Clerk Maxwell, William Thomson, 1st Baron Kelvin, Louis Pasteur, Michael Faraday, and J. J. Thomson. Isaac Newton, for example, believed that gravity caused the planets to revolve about the Sun, and credited God with the design. In the concluding General Scholium to the Philosophiae Naturalis Principia Mathematica, he wrote: "This most beautiful System