a yeast two-hybrid screen: histone-lysine N-methyltransferase (SUV39H1), histone-lysine N-methyltransferase (SUV39H2), and lysine-specific histone demethylase 1A (KDM1A). Clinical significance In a study of the genes expressed in lung squamous cell carcinomas it was found that the promoter region of CCDC37 was hyper methylated causing down regulation of the expression of CCDC37. In a separate study, CCDC37 was also found in spatial and temporal regions in mice that are associated with hereditary congenital facial paresis (HCFP) gene. However through knock out experiments in mice it was found that CCDC37 was unlikely to be a causative agent for the HCFP phenotype. References Proteins