Endogenous regeneration in the brain is the ability of cells to engage in the repair and regeneration process. While the brain has a limited capacity for regeneration, endogenous neural stem cells, as well as numerous pro-regenerative molecules, can participate in replacing and repairing damaged or diseased neurons and glial cells. Another benefit that can be achieved by using endogenous regeneration could be avoiding an immune response from the host. Neural stem cells in the adult brain During the early development of a human, neural stem cells lie in the germinal layer of the developing brain, ventricular and subventricular zones. In brain development, multipotent stem cells (those that can generate different types of cells) are present in these regions, and all of these cells differentiate into neural cell forms, such as neurons, oligodendrocytes and astrocytes. A long-held belief states that the multipotency of neural stem cells would be lost in the adult human brain. However, it is only in vitro, using neurosphere and adherent monolayer cultures, that stem cells from the adult mammalian brain have shown multipotent capacity, while the in vivo study is not convincing. Therefore, the term "neural progenitor" is used instead of "stem cell" to describe limited regeneration ability in the adult brain stem cell. Neural stem cells (NSC) reside in the subventricular zone (SVZ) of the adult human brain and the dentate gyrus of the adult mammalian hippocampus. Newly formed neurons from these regions participate in learning, memory, olfaction and mood modulation. It has not been definitively determined whether or not these stem cells are multipotents. NSC from the hippocampus of rodents, which can differentiate into dentate granule cells, have developed into many cell types when studied in culture. However, another in vivo study, using NSCs in the postnatal SVZ, showed that the stem cell is restricted to developing into different neuronal sub-type cells in the olfactory bulb. It is believed that the various spatial location niches regulate the differentiation of the neural stem cell. Neurogenesis in the central nervous system Santiago Ramon y Cajal, a neuroscience pioneer, concluded that the generation of neurons occurs only in the prenatal phase of human development, not after birth. This theory had long been the fundamental principle of neuroscience. However, in the mid-20th century, evidence of adult mammalian neurogenesis was found in rodent hippocampus and other region of the brain. In the intact adult mammalian brain, neuroregeneration maintains the function