| 5 | October 20 | @ Philadelphia | L 93–100 | Don Kojis (18) | | | The Spectrum10,365 | 3–2 |- bgcolor=#cfc | 6 | October 22 | Houston | W 110–91 | Spencer Haywood (23) | | | Seattle Center Coliseum10,182 | 4–2 |- bgcolor=#cfc | 7 | October 24 | Cincinnati | W 119–101 | Spencer Haywood (23) | | | Seattle Center Coliseum10,318 | 5–2 |- bgcolor=#cfc | 8 | October 28 | Buffalo | W 106–96 | Barry Clemens (26) | | | Seattle Center Coliseum 5,816 | 6–2 |- bgcolor=#cfc | 9 | October 30 | Los Angeles | W 115–106 | Don Kojis (26) | | | Seattle Center Coliseum13,138 | 7–2 |- bgcolor=#fcc | 10 | November 4 | @ Golden State | L 96–98 | Spencer Haywood (31) | | | Oakland–Alameda County Coliseum Arena5,814 | 7–3 |- bgcolor=#cfc | 11 | November 5 | New York | W 101–97 | Lenny Wilkens (26) | | | Seattle Center Coliseum12,638 | 8–3 |- bgcolor=#fcc | 12 | November 7 | Golden State | L 102–109 | Spencer Haywood (32) | | | Seattle Center Coliseum13,197 | 8–4 |- bgcolor=#cfc | 13 | November 11 | Cleveland | W 110–91 | Spencer Haywood (20) | | | Seattle Center Coliseum5,808 | 9–4 |- bgcolor=#fcc | 14 | November 12 | @ Los Angeles | L 107–115 | Spencer Haywood (26) | | | The Forum16,550 | 9–5 |- bgcolor=#cfc | 15 | November 13 | Boston | W 116 112 | Lenny Wilkens (21) | | | Seattle Center Coliseum12,738 | 10–5 |- bgcolor=#fcc | 16 | November 16 | @ Chicago | L 87 95 | Don Kojis (22) | | | Chicago Stadium8,907 | 10–6 |- bgcolor=#cfc | 17 | November 17 | @ Atlanta | W 112–104 | Spencer Haywood (23) | | | Alexander Memorial Coliseum5,462 | 11–6 |- bgcolor=#fcc | 18 | November 19 | Milwaukee | L 107–108 | Spencer Haywood (36) | | | Seattle Center Coliseum12,914 | 11–7 |- bgcolor=#cfc | 19 | November 20 | @ Portland | W 104–100 | Spencer Haywood (25) | | | Memorial Coliseum6,634 | 12–7 |- bgcolor=#cfc | 20 | November 21 | Philadelphia | W 127–117 | Don Smith (26) | | | Seattle Center Coliseum10,151 | 13–7 |- bgcolor=#fcc | 21 | November 25