and structure of the central nervous system (CNS). The most adult stem cells in the brain are found in the subventricular zone at the lateral walls of the lateral ventricle. Another region where neurogenesis takes place in the adult brain is the subgranular zone (SGZ) of the dentate gyrus in the hippocampus. While the exact mechanism that maintains functional NSCs in these regions is still unknown, NSCs have shown an ability to restore neurons and glia in response to certain pathological conditions. However, so far, this regeneration by NSCs is insufficient to restore the full function and structure of an injured brain. However, endogenous neuroregeneration, unlike using embryonic stem cell implantation, is anticipated to treat damaged CNS without immunogenesis or tumorigenesis. Neurogenesis in subgranular zone Progenitor cells in the dentate gyrus of the hippocampus migrate to the nearby location and differentiate into granule cells. As a part of the limbic system, new neurons of the hippocampus maintain the function of controlling mood, learning and memory. In the dentate gyrus, putative stem cells, called type 1 cells, proliferate into type 2 and type 3 cells, which are transiently amplifying, lineage-determined progenitor cells. Type 1 cells in the hippocampus are multipotent in vitro. However, although there is evidence that both new neurons and glia are generated in the hippocampus in vivo, no exact relationship of neurogenesis to type 1 cells is shown. In the hippocampus, newly formed neurons contribute only a small portion to the entire neuron population. These new neurons have different electrophysiology compared to the rest of the existing neurons. This may be evidence that generating new neurons in the SGZ is part of learning and memorizing activity of mammals. Several studies have been performed to explain the relationship between neurogenesis and learning. In the case of learning, that related to the hippocampal function, a significantly increased number of neurons are generated in the SGZ and survival of the new neurons is increased if they are required for retention of memory. In addition to learning and memorizing, neurogenesis in the SGZ is also affected by mood and emotion. With constant, inescapable stress, which usually results in emotional depression, there is a significant decrease in neurogenesis, the effect of which can be reversed by treatment with fluoxetine. Neurogenesis in subventricular zone The largest NSC population in the brain is found in the SVZ. The SVZ is considered a micro-environment called a