28 || 16 || 3:00pm || @Buffalo || 4–3 (OT) || Bishop || First Niagara Center (19,070) || 14–8–6 || 34 |- style="text-align:center; background:#cfc;" | 29 || 17 || 5:00pm || Winnipeg || 4–1 || Lehner || Scotiabank Place (19,227) || 15–8–6 || 36 |- style="text-align:center; background:#cfc;" | 30 || 19 || 7:00pm || @NY Islanders || 5–3 || Bishop || Nassau Veterans Memorial Coliseum (10,668) || 16–8–6 || 38 |- style="text-align:center; background:#fcf;" | 31 || 21 || 7:30pm || Boston || 1–2 || Lehner || Scotiabank Place (19,603) || 16–9–6 || 38 |- style="text-align:center; background:#cfc;" | 32 || 23 || 2:00pm || Tampa Bay || 5–3 || Lehner || Scotiabank Place (20,016) || 17–9–6 || 40 |- style="text-align:center; background:#cfc;" | 33 || 25 || 7:30pm || New Jersey || 3–2 (SO) || Bishop || Scotiabank Place (18,902) || 18–9–6 || 42 |- style="text-align:center; background:#cfc;" | 34 || 28 || 7:30pm || NY Rangers || 3–0 || Bishop || Scotiabank Place (19,447) || 19–9–6 || 44 |- style="text-align:center; background:#fcf;" | 35 || 30 || 7:00pm || Toronto || 0–4 || Bishop || Scotiabank Place (20,183) || 19–10–6 || 44 |- |- style="text-align:center; background:#fcf;" | 36 || 2 || 7:00pm || @Boston || 2–3 || Lehner || TD Garden (17,565) || 19–11–6 || 44 |- style="text-align:center; background:#fcf;" | 37 || 5 || 7:00pm || @Buffalo || 2–4 || Lehner || First Niagara Center (19,070) || 19–12–6 || 44 |- style="text-align:center; background:#fcf;" | 38 || 7 || 6:00pm || @Florida || 1–2 || Anderson || BankAtlantic Center (15,634)|| 19–13–6 || 44 |- style="text-align:center; background:#fcf;" | 39 || 9 || 7:30pm || @Tampa Bay || 2–3 || Anderson || Tampa Bay Times Forum (17,323) || 19–14–6 || 44 |- style="text-align:center; background:#cfc;" | 40 || 11 || 7:00pm || @Philadelphia || 3–1 || Lehner || Wells Fargo Center (19,598) || 20–14–6 || 46 |- style="text-align:center; background:#cfc;" | 41 || 12 || 7:00pm || @New Jersey || 2–0 || Anderson || Prudential Center (16,099) || 21–14–6 || 48 |- style="text-align:center; background:#ccc;" | – || 15 || 7:00pm || @Boston ||colspan="4" | Game rescheduled to April 28 due to the Boston Marathon bombing. || |- style="text-align:center; background:#cfc;" | 42 || 16 || 7:30pm || Carolina || 3–2 || Anderson || Scotiabank Place (19,181) || 22–14–6 || 50 |- style="text-align:center; background:#cfc;" | 43 || 18 || 7:30pm || Washington || 3–1 || Anderson || Scotiabank Place (19,965)