|| 2–1 || Miller (11–13–4) || Bell Centre (21,273) || 13–15–4 |- align="center" bgcolor="#ffbbbb" | 33 || 26 || @Tampa Bay Lightning || 1–2 || Miller (11–14–4) || Tampa Bay Times Forum (19,204) || 13–16–4 |- align="center" bgcolor="#ffffcc" | 34 || 28 || @Florida Panthers || 4–5 (SO) || Miller (11–14–5) || BB&T Center (17,044) || 13–16–5 |- align="center" bgcolor="#ffffcc" | 35 || 30 || Washington Capitals || 3–4 (SO) || Enroth (2–2–1) || First Niagara Center (19,070) || 13–16–6 |- align="center" bgcolor="#ffbbbb" | 36 || 31 || Boston Bruins || 0–2 || Miller (11–15–5) || First Niagara Center (19,027) || 13–17–6 |- |- align="center" bgcolor="#ccffcc" | 37 || 2 || @Pittsburgh Penguins || 4–1 || Miller (12–15–5) || Consol Energy Center (18,642) || 14–17–6 |- align="center" bgcolor="#ccffcc" | 38 || 5 || Ottawa Senators || 4–2 || Miller (13–15–5) || First Niagara Center (18,811) || 15–17–6 |- align="center" bgcolor="#ccffcc" | 39 || 7 || New Jersey Devils || 3–2 (SO) || Miller (14–15–5) || First Niagara Center (18,703) || 16–17–6 |- align="center" bgcolor="#ffbbbb" | 40 || 9 || @Winnipeg Jets || 1–4 || Miller (14–16–5) || MTS Centre (15,004) || 16–18–6 |- align="center" bgcolor="#ffbbbb" | 41 || 11 || Montreal Canadiens || 1–5 || Miller (14–17–5) || First Niagara Center (19,070) || 16–19–6 |- align="center" bgcolor="#ccffcc" | 42 || 13 || Philadelphia Flyers || 1–0|| Enroth (3–2–1) || First Niagara Center (19,070) || 17–19–6 |- align="center" bgcolor="#ccffcc" | 43 || 14 || Tampa Bay Lightning || 3–1|| Enroth (4–2–1) || First Niagara Center (18,991) || 18–19–6 |- align="center" bgcolor="#ccffcc" | 44 || 17 || @Boston Bruins || 3–2 (SO)|| Miller (15–17–5) || TD Garden (17,565) || 19–19–6 |- align="center" bgcolor="#ffbbbb" | 45 || 19 || New York Rangers || 4–8 || Enroth (4–3–1) || First Niagara Center (19,003) || 19–20–6 |- align="center" bgcolor="#cccccc" | – || 20 || @Pittsburgh Penguins ||colspan="4" | Game rescheduled to April 23 due to effects on Pittsburgh's schedule resulting from the manhunt for the Boston Marathon bombing suspect. |- align="center" bgcolor="#ffbbbb" | 46 || 22 || Winnipeg Jets || 1–2|| Enroth (4–4–1) || First Niagara Center (18,654) || 19–21–6 |- align="center" bgcolor="#ccffcc" | 47 || 23 || @Pittsburgh Penguins || 4–2 || Miller (16–17–5) || Consol Energy Center (18,630) || 20–21–6 |- align="center" bgcolor="#ccffcc" | 48 || 26 || New York Islanders || 2–1 (SO) || Miller (17–17–5) || First Niagara Center (19,070) ||