|- style="text-align:center; background:#fcc;" | 25 || 7 || @ Boston Bruins || 2–4 || TD Garden (17,565) || 15–10–0 || 30 || Scrivens (6–7–0) |- style="text-align:center; background:#ffc;" | 26 || 9 || Pittsburgh Penguins || 4–5 (SO) || Air Canada Centre (19,418) || 15–10–1 || 31 || Reimer (9–3–1) |- style="text-align:center; background:#fcc;" | 27 || 12 || @ Winnipeg Jets || 2–5 || MTS Centre (15,004) || 15–11–1 || 31 || Reimer (9–4–1) |- style="text-align:center; background:#fcc;" | 28 || 14 || Pittsburgh Penguins || 1–3 || Air Canada Centre (19,561) || 15–12–1 || 31 || Scrivens (6–8–0) |- style="text-align:center; background:#ffc;" | 29 || 16 || Winnipeg Jets || 4–5 (SO) || Air Canada Centre (19,401) || 15–12–2 || 32 || Reimer (9–4–2) |- style="text-align:center; background:#cfc;" | 30 || 20 || Tampa Bay Lightning || 4–2 || Air Canada Centre (19,433) || 16–12–2 || 34 || Reimer (10–4–2) |- style="text-align:center; background:#ffc;" | 31 || 21 || @ Buffalo Sabres || 4–5 (SO) || First Niagara Center (19,070) || 16–12–3 || 35 || Reimer (10–4–3) |- style="text-align:center; background:#cfc;" | 32 || 23 || Boston Bruins || 3–2 || Air Canada Centre (19,236) || 17–12–3 || 37 || Reimer (11–4–3) |- style="text-align:center; background:#ffc;" | 33 || 25 || @ Boston Bruins || 2–3 (SO) || TD Garden (17,565) || 17–12–4 || 38 || Reimer (11–4–4) |- style="text-align:center; background:#cfc;" | 34 || 26 || Florida Panthers || 3–2 || Air Canada Centre (19,379) || 18–12–4 || 40 || Scrivens (7–8–0) |- style="text-align:center; background:#cfc;" | 35 || 28 || Carolina Hurricanes || 6–3 || Air Canada Centre (19,236) || 19–12–4 || 42 || Reimer (12–4–4) |- style="text-align:center; background:#cfc;" | 36 || 30 || @ Ottawa Senators || 4–0 || Scotiabank Place (20,183) || 20–12–4 || 44 || Reimer (13–4–4) |- |- style="text-align:center; background:#fcc;" | 37 || 4 || Philadelphia Flyers || 3–5 || Air Canada Centre (19,619) || 20–13–4 || 44 || Reimer (13–5–4) |- style="text-align:center; background:#cfc;" | 38 || 6 || @ New Jersey Devils || 2–1 || Prudential Center (17,625) || 21–13–4 || 46 || Reimer (14–5–4) |- style="text-align:center; background:#cfc;" | 39 || 8 || New York Rangers || 4–3 || Air Canada Centre (19,437) || 22–13–4 || 48 || Reimer (15–5–4) |- style="text-align:center; background:#ffc;" | 40 || 10 || @ New York Rangers || 2–3 (SO) || Madison Square Garden (17,200) || 22–13–5 || 49 || Reimer (15–5–5) |- style="text-align:center; background:#cfc;" |