the husband and lab partner of Rosie Octavius (portrayed by Donna Murphy). Initially a well-meaning scientist working with Oscorp to develop a form of self-sustainable energy that would benefit mankind, Octavius turns to villainy after his experiment goes wrong, resulting in Rosie's death and Octavius losing control of his tentacle harness' artificial intelligence, which begins to influence his mind and actions and brings him into conflict with Spider-Man. With the web-slinger's help, Octavius eventually sees the error of his ways and sacrifices himself to sink a fusion reactor he built into the East River, where he drowns. Molina reprised his role in the Marvel Cinematic Universe (MCU) film Spider-Man: No Way Home (2021). In April 2021, Molina said it was "wonderful" to play the character again. Additionally, he was digitally de-aged in the film to resemble how he appeared in 2004, despite his concerns about his fighting style not looking realistic due to his age in a similar way to Robert De Niro's character in The Irishman (2019). Prior to his death, Octavius is transported to an alternate universe due to a magic spell gone wrong and receives a cure from an alternate universe version of Spider-Man. A female incarnation of Doctor Octopus named Dr. Olivia "Liv" Octavius appears in Spider-Man: Into the Spider-Verse, voiced by Kathryn Hahn. She is the head scientist of Alchemax and the Kingpin's right-hand woman who sports a large beehive hairstyle, glasses with octagonal lenses, and pneumatic tentacles tipped with claws. Under the Kingpin's orders, she builds a super-collider to access parallel universes. In spite of the initial tests nearly destroying New York City and bringing several alternate reality versions of Spider-Man to their universe, the Kingpin orders Liv to continue working on the collider. She later encounters Miles Morales and an alternate reality Peter Parker while they are infiltrating Alchemax, but fails to catch them. After confronting the assembled Spider-People at May Parker's house alongside the Kingpin and his other henchmen and failing to stop them a second time, Liv tries to stop the heroes at the collider, only to be hit by a truck when the machine goes haywire and melds her universe with aspects of others. Additionally, a Doctor Octopus from Gwen Stacy's universe makes a non-speaking cameo appearance while fighting her in a flashback before she was transported to Miles' Earth. An alternate Otto Octavius as the Superior Spider-Man will be