a main role in Guy Ritchie's popular 1998 London gangster film Lock, Stock and Two Smoking Barrels. Flemyng later claimed to have lost so much money while playing poker with the film's backers in between takes on set that he had to work on the four days of re-shoots the film required for no fee. He went on to appear in films such as The Red Violin and Deep Rising (1998), Snatch (2000), George A. Romero's Bruiser (2000) and Rock Star (2001). Flemyng also starred in the short film Feeling Good, written by Dexter Fletcher, whom he met while working on Lock, Stock and Two Smoking Barrels. In the early 2000s he featured in two big-budget Hollywood films which were adaptations of Alan Moore comic books; as John Netley in 2001's From Hell, with Johnny Depp, and 2003's The League of Extraordinary Gentlemen, with Sean Connery, in which Flemyng played Dr. Henry Jekyll and Edward Hyde. The latter film was a disappointment, but Flemyng commented that: "It was a bit of a nightmare... the film cost a fortune and didn't make back the money it was meant to... But I still get a huge kick out of doing films like that and From Hell. Any day you walk onto a set and Sean Connery or Johnny Depp or Brad Pitt is there has to be a good day." In parallel with his film career, Flemyng has continued to take various television roles. He told BBC News Online in 2004 that: "Of the 40 feature films I've made, 15 of them failed to make it onto the screen and have only ever been seen by cast and crew. It is very frustrating when a film you really believe in remains unseen. That's not a problem with television. If you're a painter you don't paint a picture and then stick it under the bed – you want people to see it." In 2005 he played the famous science-fiction role of Professor Bernard Quatermass when digital television channel BBC Four produced a live remake of the 1953 serial The Quatermass Experiment. In 2005 he also played the part of Dimitry, a Russian ex-biological weapons specialist, in Transporter 2, where he was briefly reunited with Jason Statham. In 2009, Flemyng joined the cast of the ITV science fiction cult drama series Primeval during its third series, as maverick ex-policeman Danny Quinn. He received top