In the leading city of Florence, the republic was from 1434 onward dominated by the increasingly monarchical Medici family. Initially, under Cosimo the Elder, Piero the Gouty, Lorenzo the Magnificent and Piero the Unfortunate, the forms of the republic were retained and the Medici ruled without a title, usually without even a formal office. These rulers presided over the Florentine Renaissance. There was a return to the republic from 1494 to 1512, when first Girolamo Savonarola then Piero Soderini oversaw the state. Cardinal Giovanni de' Medici retook the city with Spanish forces in 1512, before going to Rome to become Pope Leo X. Florence was dominated by a series of papal proxies until 1527 when the citizens declared the republic again, only to have it taken from them again in 1530 after a siege by an Imperial and Spanish army. At this point Pope Clement VII and Charles V appointed Alessandro de' Medici as the first formally hereditary ruler. The Sienese commune was not incorporated into Tuscany until 1555, and during the 15th century Siena enjoyed a cultural 'Sienese Renaissance' with its own more conservative character. Lucca remained an independent Republic until 1847 when it became part of Grand Duchy of Tuscany by the will of its people. Piombino was another minor independent state, under both Spanish and Tuscan influence. Grand Duchy of Tuscany Later Medici For most of the 16th century the Medici ruled Florence and Tuscany quite successfully, expanding the state's territory greatly by acquiring Siena. The Medici were patrons of science and the arts which flowered for much of their reign. Tuscany became a more cohesive and unified state during these years, rather than simply the dominion of a dominating city, Florence. As time went on, Tuscany was transformed in a number of ways, not always positively. Most importantly, the economy underwent a fundamental change in character. The wool industry was decimated during these later years, though the silk industry was, to some extent, able to replace it. Nonetheless, industry, which had shaped and sustained Florence since the Middle Ages, began to decline throughout the 17th century. Investment in business became less lucrative and there was some "re-feudalization" of the Tuscan state with many patricians investing in land instead of industry. Tuscany is generally agreed to have declined greatly by the early 18th century under a series of inept grand dukes. The Medici dukes were as follows.