1982 Mackerras was the first Australian national appointed chief conductor of the Sydney Symphony Orchestra, a post he held until 1985. he directed the Welsh National Opera from 1987 to 1992, where his Janáček productions won particular praise. One of the highlights of the 1991 season was the reopening of the Estates Theatre in Prague, scene of the original premiere of Mozart's Don Giovanni, in which Mackerras conducted a new production of that opera to mark the bicentenary of Mozart's death. As Conductor Emeritus of Welsh National Opera, his successes included Tristan und Isolde, The Yeomen of the Guard, and La clemenza di Tito (all of which productions were brought to London). He was the principal guest conductor of the Scottish Chamber Orchestra (SCO) from 1992 to 1995, and held the title of Conductor Laureate with the SCO. He was principal guest conductor of the Royal Philharmonic Orchestra from 1993 to 1996. During the same period, he was also principal guest conductor of the San Francisco Opera. From 1998 to 2001 he was the music director of the Orchestra of St. Luke's. From 1987, he regularly conducted the Orchestra of the Age of Enlightenment and was appointed Emeritus Conductor in 2007. In 2004 he became principal guest conductor of the Philharmonia Orchestra. He was also principal guest conductor of the Czech Philharmonic. With the Royal Opera, he conducted productions of Gounod's Roméo et Juliette and Handel's Semele. Mackerras also had a long association with the Metropolitan Opera, where he conducted The Makropulos Case, Káťa Kabanová, Le prophète, Lucia di Lammermoor, Billy Budd, Hansel and Gretel and The Magic Flute. In August 2008, Mackerras was announced as the new Honorary President of the Edinburgh International Festival Society. He was only the second person to hold this role, after Yehudi Menuhin. As the original part of the largest arts festival in the world, the Edinburgh International Festival featured performances from Mackerras throughout six decades since his first in 1952. Mackerras summarised his strategy for working with an orchestra as follows: Mackerras was the President of Trinity College of Music, London. He also served as Music Advisor to City Opera of Vancouver, a professional chamber opera company led by conductor Charles Barber. He was also a Patron of Bampton Classical Opera. From 1999 Mackerras was a Patron of the Australian children's cancer charity Redkite. On 18 December 2008, Mackerras served as the conductor