when Otto joyously announced his future marriage to his mother, her feelings were not reciprocated. Believing that no woman was good enough for her son, she made him feel guilty that she was going to be pushed aside for his bride-to-be. Shocked that he hurt his mother, and to please her, Otto broke off the engagement with Mary Alice. Later, when he discovered that his mother had begun dating a librarian, he rebuked her, causing her to have a fatal heart attack in the heat of their argument. With the death of his mother and Mary Alice Anders out of his life, Octavius' disposition towards nearly everyone became mean-spirited, and he had become more distracted from paying attention to detail and safety precautions in his work. His co-workers often called him "Doctor Octopus" behind his back, a pun on his actual name inspired by the four-armed apparatus; he was aware of this insult, but he barely cared. Criminal career begins During an accidental radiation leak that ended in an explosion, the apparatus became fused to Octavius's body. It was later revealed that the radiation (or possibly his own latent mutation) had mutated his brain so that he could control the movement of the arms using his thoughts alone. The tentacles have since been surgically removed from his body, although Octavius retains the power to control them telepathically from great distances. The accident also seemingly damaged his brain (although it was later suggested that what was interpreted as brain damage was, in fact, his mind rewiring itself to accommodate four extra limbs), and the scientist turned to a life of crime, first taking the hospital hostage and calling himself "Doctor Octopus" from the derogatory name that his co-workers had given him. Though Doctor Octopus himself is portly, in poor physical shape, and is near-sighted, with his harness attached he is physically more than a match for Spider-Man. The accident also made his eyes very sensitive to light, requiring him to wear glasses with shaded lenses. In their first encounter, Doctor Octopus defeated Spider-Man, tossing him out of a window. Following this defeat, Spider-Man considered giving up his heroic career but was inspired to continue by the Human Torch, and ultimately defeated Doctor Octopus. Over the years, Doctor Octopus has become one of the most identifiable members of Spider-Man's rogues gallery. Doctor Octopus formed the original Sinister Six to fight Spider-Man after