(0–2) || || 22,720 || 24–24 |- style="text-align:center; background:#fbb;" | 49 || May 27 || @ Athletics || 2–6 || Ziegler (1–0) || Simón (1–1) || || 12,110 || 24–25 |- style="text-align:center; background:#fbb;" | 50 || May 28 || @ Athletics || 2–4 || Outman (1–0) || Bergesen (1–6) || Fuentes (10) || 23,795 || 24–26 |- style="text-align:center; background:#fbb;" | 51 || May 29 || @ Athletics || 4–6 || Moscoso (2–0) || Britton (5–3) || Fuentes (11) || 15,373 || 24–27 |- style="text-align:center; background:#fbb;" | 52 || May 30 || @ Mariners || 3–4 || Fister (3–5) || Arrieta (6–3) || League (14) || 22,819 || 24–28 |- style="text-align:center; background:#fbb;" | 53 || May 31 || @ Mariners || 2–3 || Ray (2–1) || Guthrie (2–7) || League (15) || 11,692 || 24–29 |- |- style="text-align:center; background:#cfc;" | 54 || June 1 || @ Mariners || 2–1 || Johnson (4–1) || Wright (1–2) || Gregg (9) || 18,036 || 25–29 |- style="text-align:center; background:#fbb;" | 55 || June 3 || Blue Jays || 4–8 || Villanueva (3–0) || Britton (5–4) || || 18,587 || 25–30 |- style="text-align:center; background:#cfc;" | 56 || June 4 || Blue Jays || 5–3 || Arrieta (7–3) || Romero (5–5) || Gregg (10) || 20,086 || 26–30 |- style="text-align:center; background:#fbb;" | 57 || June 5 || Blue Jays || 4–7 || Reyes (2–4) || Guthrie (2–8) || || 25,431 || 26–31 |- style="text-align:center; background:#cfc;" | 58 || June 6 || Athletics || 4–2 || Matusz (1–0) || Gonzalez (5–4) || Gregg (11) || 10,556 || 27–31 |- style="text-align:center; background:#cfc;" | 59 || June 7 || Athletics || 4–0 || Jakubauskas (1–0) || Moscoso (2–2) || || 13,652 || 28–31 |- style="text-align:center; background:#cfc;" | 60 || June 8 || Athletics || 3–2 || Britton (6–4) || Outman (1–1) || Gregg (12) || 11,760 || 29–31 |- style="text-align:center; background:#cfc;" | 61 || June 10 || Rays || 7–0 || Arrieta (8–3) || Hellickson (7–4) || || 17,900 || 30–31 |- style="text-align:center; background:#fbb;" | 62 || June 11 || Rays || 5–7 (11) || Cruz (4–0) || Accardo (3–2) || Farnsworth (14) || 25,541 || 30–32 |- style="text-align:center; background:#fbb;" | 63 || June 12 || Rays || 6–9 || Davis (5–5) || Matusz (1–1) || Howell (1) || 22,032 || 30–33 |- style="text-align:center; background:#fbb;" | 64 || June 14 || @ Blue Jays || 5–6 (11) || Camp (1–1)