|| May 14 || Phillies || 5–3 || Jurrjens (5–0) || Blanton (1–2) || Kimbrel (9) || 35,238 || 2:39 || 22–19 |- style="text-align:center; background:#bfb;" | 42 || May 15 || Phillies || 3–2 || Venters (3–0) || Halladay (5–3) || Kimbrel (10) || 42,117 || 2:38 || 23–19 |- style="text-align:center; background:#bfb;" | 43 || May 16 || Astros || 3–2 || Hanson (5–3) || Abad (1–4) || Kimbrel (11) || 17,416 || 2:44 || 24–19 |- style="text-align:center; background:#bfb;" | 44 || May 17 || Astros || 3–1 (11) || Gearrin (1–1) || Fulchino (0–2) || || 21,085 || 3:09 || 25–19 |- style="text-align:center; background:#fbb;" | 44 || May 18 || @ Diamondbacks || 4–5 (11) || Heilman (2–0) || Kimbrel (1–2) || || 19,773 || 3:19 || 25–20 |- style="text-align:center; background:#fbb;" | 46 || May 19 || @ Diamondbacks || 1–2 || Collmenter (2–0) || Jurrjens (5–1) || Putz (10) || 23,413 || 2:19 || 25–21 |- style="text-align:center; background:#fbb;" | 47 || May 20 || @ Angels || 0–9 || Santana (2–4) || Hudson (4–4) || || 40,211 || 2:28 || 25–22 |- style="text-align:center; background:#bfb;" | 48 || May 21 || @ Angels || 5–4 (12) || Proctor (1–0) || Bell (1–1) || Kimbrel (12) || 43,511 || 3:57 || 26–22 |- style="text-align:center; background:#fbb;" | 49 || May 22 || @ Angels || 1–4 || Chatwood (3–2) || Lowe (3–4) || Walden (8) || 40,098 || 2:37 || 26–23 |- style="text-align:center; background:#bfb;" | 50 || May 24 || @ Pirates || 2–0 || Jurrjens (6–1) || Morton (5–2) || Kimbrel (13) || 16,873 || 2:33 || 27–23 |- style="text-align:center; background:#bfb;" | 51 || May 25 || @ Pirates || 4–2 (11) || Sherrill (1–0) || Karstens (3–3) || Kimbrel (14) || 21,497 || 3:16 || 28–23 |- style="text-align:center; background:#fbb;" | 52 || May 27 || Reds || 1–5 || Leake (4–2) || Hanson (5–4) || || 30,701 || 3:27 || 28–24 |- style="text-align:center; background:#bfb;" | 53 || May 28 || Reds || 7–6 (12) || Linebrink (1–1) || Fisher (0–2) || || 36,615 || 4:03 || 29–24 |- style="text-align:center; background:#bfb;" | 54 || May 29 || Reds || 2–1 || Jurrjens (7–1) || Cueto (2–2) || Kimbrel (15) || 36,392 || 2:29 || 30–24 |- style="text-align:center; background:#fbb;" | 55 || May 30 || Padres || 2–3 (10) || Qualls (3–2) || Sherrill (1–1) || Bell (13) || 25,832 ||