Mariners || 3–0 || Bédard (3–4) || Duensing (2–5) || League (12) || 38,860 || 16–32 |- style="text-align:center; background:#fbb;" | 49 || May 27 || Angels || 6–5 || Downs (3–1) || Hoey (0–2) ||Walden (11) || 38,976 || 16–33 |- style="text-align:center; background:#bfb;" | 50 || May 28 || Angels || 1–0 (10) || Burnett (1–3) || Takahashi (1–1) || || 39,824 || 17–33 |- style="text-align:center; background:#fbb;" | 51 || May 29 || Angels || 6–5 || Haren (5–3) || Pavano (2–5) || Walden (12) || 39,867 || 17–34 |- style="text-align:center; background:#fbb;" | 52 || May 30 || @ Tigers || 6–5 || Alburquerque (2–1) || Burnett (1–4) || Valverde (13) || 30,198 || 17–35 |- style="text-align:center; background:#fbb;" | 53 || May 31 || @ Tigers || 8–7 || Alburquerque (3–1) || Dumatrait (0–1) || Benoit (2) || 22,649 || 17-36 |- |- style="text-align:center; background:#fbb;" | 54 || June 1 || @ Tigers || 4–2 || Porcello (5–3) || Baker (2–4) || Valverde (14) || 24,363 || 17–37 |- style="text-align:center; background:#bfb;" | 55 || June 2 || @ Royals || 8–2 || Swarzak (1–2)|| O'Sullivan (2–5) || || 14,584 || 18–37 |- style="text-align:center; background:#bfb;" | 56 || June 3 || @ Royals || 5–2 || Pavano (3–5) || Duffy (0–1) || || 32,443 || 19–37 |- style="text-align:center; background:#bfb;" | 57 || June 4 || @ Royals || 7–2 || Blackburn (5–4) || Hochevar (3–6) || || 27,861 || 20–37 |- style="text-align:center; background:#bfb;" | 58 || June 5 || @ Royals || 6–0 || Duensing (3–5) || Francis (2–6) || || 21,704 || 21–37 |- style="text-align:center; background:#bfb;" | 59 || June 6 || @ Indians || 6–4 || Baker (3–4) || Tomlin (7–3) || Capps (8) || 15,278 || 22–37 |- style="text-align:center; background:#fbb;" | 60 || June 7 || @ Indians || 1–0 || Carrasco (5–3) || Liriano (3–6) || C. Perez (15) || 15,498 || 22–38 |- style="text-align:center; background:#bfb;" | 61 || June 8 || @ Indians || 3–2 (10) || Capps (2–3) || C. Perez (2–2) || Dumatrait (1) || 15,849 || 23–38 |- style="text-align:center; background:#bfb;" | 62 || June 9 || Rangers || 5–4 || Hoey (1–2) || Lowe (1–1) || || 38,761 || 24–38 |- style="text-align:center; background:#fbb;" | 63 || June 10 || Rangers || 9–3 || Wilson (7–3) || Duensing (3–6) || || 38,907 || 24–39 |- style="text-align:center; background:#bfb;" | 64 || June 11 || Rangers