@ Rangers || 6–7 || Feliz (2–3) || Gray (0–1) || || 25,214 || 49–66 || |- style="text-align:center; background:#bfb;" | 116 || August 10 || @ Rangers || 4–3 || Vargas (7–10)|| Uehara (1–2) || League (27) || 30,087 || 50–66 || |- style="text-align:center; background:#fbb;" | 117 || August 12 || Red Sox || 4–6 || Lackey (11–8) || Beavan (3–3) || Papelbon (27) || 40,682 || 50–67 || |- style="text-align:center; background:#bfb;" | 118 || August 13 || Red Sox || 5–4 || Hernández (11–10) || Beckett (9–5) || League (28) || 41,326 || 51–67 || |- style="text-align:center; background:#bfb;" | 119 || August 14 || Red Sox || 5–3 || Furbush (3–4) || Wakefield (6–5) || League (29) || 43,777 || 52–67 || |- style="text-align:center; background:#bfb;" | 120 || August 15 || Blue Jays || 6–5 || Wilhelmsen (1–0) || Rauch (5–4) || League (30) || 28,530 || 53–67 || |- style="text-align:center; background:#fbb;" | 121 || August 16 || Blue Jays || 7–13 || Perez (2–2) || Vargas (7–11) || || 23,089 || 53–68 || |- style="text-align:center; background:#fbb;" | 122 || August 17 || Blue Jays || 1–5 || Morrow (9–7) || Beavan (3–4) || || 26,579 || 53–69 || |- style="text-align:center; background:#fbb;" | 123 || August 19 || @ Rays || 2–3 || Cruz (5–0) || Hernández (11–11) || Farnsworth (22) || 14,884 || 53–70 || |- style="text-align:center; background:#fbb;" | 124 || August 20 || @ Rays || 0–8 || Hellickson (11–8) || Furbush (3–5) || || 20,184 || 53–71 || |- style="text-align:center; background:#fbb;" | 125 || August 21 || @ Rays || 7–8 || Farnsworth (5–1) || Cortes (0–2) || || 17,226 || 53–72 || |- style="text-align:center; background:#bfb;" | 126 || August 22 || @ Indians || 3–2 || Ruffin (1–0) || Perez (2–6) || League (31) || 21,582 || 54–72 || |- style="text-align:center; background:#fbb;" | 127 || August 23 || @ Indians || 5–7 || Perez (3–6) || League (1–5) || || 22,805 || 54–73 || |- style="text-align:center; background:#bfb;" | 128 || August 23 || @ Indians || 12–7 || Vasquez (1–0) || McAllister (0–1) || Gray (1) || 22,590 || 55–73 || |- style="text-align:center; background:#bfb;" | 129 || August 24 || @ Indians || 9–2 || Hernández (12–11) || Tomlin (12–7) || || 16,037 || 56–73 || |- style="text-align:center; background:#fbb;" | 130 || August 26 || White Sox || 2–4 || Peavy (6–6) || Furbush (3–6)