|- style="text-align:center; background:#fbb;" |77||June 24||Rays||1–5||Shields (8–4)||W. Rodríguez (5–4)||||26,682||Minute Maid Park||28–49||L1 |- style="text-align:center; background:#fbb;" |78||June 25||Rays||2–7||Davis (7–5)||Norris (4–6)||Farnsworth (16)||27,208||Minute Maid Park||28–50||L2 |- style="text-align:center; background:#fbb;" |79||June 26||Rays||10–14||Howell (1–1)||López (1–4)||||23,965||Minute Maid Park||28–51||L3 |- style="text-align:center; background:#fbb;" |80||June 28||Rangers||3–7||Wilson (6–3)||Lyles (0–3)||Feliz (15)||29,132||Minute Maid Park||28–52||L4 |- style="text-align:center; background:#fbb;" |81||June 29||Rangers||2–3||Lewis (7–7)||Myers (3–7)||Feliz (16)||24,472||Minute Maid Park||28–53||L5 |- style="text-align:center; background:#bfb;" |82||June 30||Rangers||7–0||W. Rodríguez (6–4)||Harrison (6–7)||||25,938||Minute Maid Park||29–53||W1 |- |- style="text-align:center; background:#fbb;" |83||July 1||Red Sox||5–7||Wheeler (1–1)||Escalona (1–1)||Papelbon (16)||36,279||Minute Maid Park||29–54||L1 |- style="text-align:center; background:#fbb;" |84||July 2||Red Sox||4–10||Miller (2–0)||Happ (3–10)||||39,021||Minute Maid Park||29–55||L2 |- style="text-align:center; background:#fbb;" |85||July 3||Red Sox||1–2||Beckett (7–3)||Melancon (5–2)||Papelbon (17)||38,035||Minute Maid Park||29–56||L3 |- style="text-align:center; background:#fbb;" |86||July 4||@Pirates||3–5||Maholm (5–9)||Myers (3–8)||Hanrahan (25)||36,942||PNC Park||29–57||L4 |- style="text-align:center; background:#fbb;" |87||July 5||@Pirates||1–5||Karstens (7–4)||W. Rodríguez (6–5)||||18,151||PNC Park||29–58||L5 |- style="text-align:center; background:#bfb;" |88||July 6||@Pirates||8–2||Norris (5–6)||Morton (7–5)||||18,910||PNC Park||30–58||W1 |- style="text-align:center; background:#fbb;" |89||July 7||@Marlins||0–5||Hand (1–3)||Happ (3–11)||||17,806||Sun Life Stadium||30–59||L1 |- style="text-align:center; background:#fbb;" |90||July 8||@Marlins||3–6||Vázquez (5–8)||Lyles (0–4)||Núñez (24)||17,044||Sun Life Stadium||30–60||L2 |- style="text-align:center; background:#fbb;" |91||July 9||@Marlins||1–6||Nolasco (6–5)||Myers (3–9)||||20,402||Sun Life Stadium||30–61||L3 |- style="text-align:center; background:#fbb;" |92||July 10||@Marlins||4–5||Volstad (5–8)||W. Rodríguez (6–6)||Núñez (25)||17,123||Sun Life Stadium||30–62||L4 |- style="text-align:center; background:#bbcaff;" |–||July 12|| 82nd All-Star Game||colspan=8|National League 5, American League 1 (Phoenix, Arizona; Chase Field) |- style="text-align:center; background:#fbb;" |93||July 15||Pirates||0–4||Karstens (8–4)||Myers (3–10)||||27,787||Minute Maid Park||30–63||L5 |- style="text-align:center; background:#bfb;" |94||July 16||Pirates||6–4||Escalona (2–1)||Veras (2–2)||Melancon (7)||35,081||Minute Maid Park||31–63||W1 |- style="text-align:center; background:#fbb;" |95||July 17||Pirates||5–7 (11)||Leroux (1–0)||Melancon (5–3)||Resop (1)||24,580||Minute Maid Park||31–64||L1 |- style="text-align:center; background:#fbb;" |96||July 18||Nationals||2–5||Marquis (8–4)||Lyles (0–5)||Storen (25)||28,975||Minute Maid Park||31–65||L2 |- style="text-align:center; background:#bfb;" |97||July 19||Nationals||7–6||Happ (4–11)||Zimmermann (6–8)||Melancon (8)||32,418||Minute Maid Park||32–65||W1 |- style="text-align:center; background:#bfb;" |98||July 20||Nationals||3–2 (11)||López (2–4)||Coffey (3–1)||||29,605||Minute Maid Park||33–65||W2 |- style="text-align:center; background:#fbb;" |99||July 22||@Cubs||2–4||Zambrano (7–5)||Norris (5–7)||Marshall (3)||39,855||Wrigley Field||33–66||L1 |- style="text-align:center; background:#fbb;" |100||July 23||@Cubs||1–5||Wells (2–3)||W. Rodríguez (6–7)||||40,486||Wrigley Field||33–67||L2 |- style="text-align:center; background:#fbb;" |101||July 24||@Cubs||4–5 (10)||John Grabow (2–0)||Carpenter (0–1)||||40,406||Wrigley Field||33–68||L3 |- style="text-align:center; background:#fbb;" |102||July 25||@Cardinals||5–10||McClellan (7–6)||Happ (4–12)||Boggs (4)||38,074||Busch Stadium||33–69||L4 |- style="text-align:center; background:#fbb;" |103||July 26||@Cardinals||1–3||Westbrook (9–4)||Myers (3–11)||Salas (19)||35,588||Busch Stadium||33–70||L5 |- style="text-align:center; background:#bfb;" |104||July 27||@Cardinals||4–2||F. Rodriguez (2–0)||Boggs (0–3)||Melancon (9)||35,679||Busch Stadium||34–70||W1 |- style="text-align:center; background:#bfb;" |105||July 28||@Cardinals||5–3||W. Rodríguez (7–7)||García (10–5)||Melancon (10)||38,794||Busch Stadium||35–70||W2 |- style="text-align:center; background:#fbb;" |106||July 29||@Brewers||0–4||Wolf (7–8)||Lyles (0–6)||||41,672||Miller Park||35–71||L1 |- style="text-align:center; background:#fbb;" |107||July 30||@Brewers||2–6||Gallardo (12–7)||Happ (4–13)||||44,306||Miller Park||35–72||L2 |- style="text-align:center; background:#fbb;" |108||July 31||@Brewers||4–5||Rodríguez (4–2)||F. Rodríguez (2–1)||Axford (31)||41,738||Miller Park||35–73||L3 |- |- style="text-align:center; background:#bfb;" |109||August 1||Reds||4–3 (10)||Melancon (6–3)||Ondrusek (4–4)||||21,502||Minute Maid Park||36–73||W1 |- style="text-align:center; background:#fbb;" |110||August 2||Reds||1–5||Bailey (6–5)||W. Rodríguez (7–8)||||22,603||Minute Maid Park||36–74||L1 |- style="text-align:center; background:#bfb;" |111||August 3||Reds||5–4||Lyles (1–6)||Masset (1–5)||Melancon (11)||22,102||Minute Maid Park||37–74||W1 |- style="text-align:center; background:#fbb;" |112||August 5||Brewers||1–8||Gallardo (13–7)||Happ (4–14)||||25,811||Minute Maid Park||37–75||L1 |- style="text-align:center; background:#fbb;" |113||August 6||Brewers||5–7||Narveson (8–6)||Myers (3–12)||Axford (32)||30,561||Minute Maid Park||37–76||L2 |- style="text-align:center; background:#fbb;" |114||August 7||Brewers||3–7||Greinke (10–4)||Norris (5–8)||||22,885||Minute Maid Park||37–77||L3 |- style="text-align:center; background:#bfb;" |115||August 8||@Diamondbacks||9–1||W. Rodríguez (8–8)||Hudson (11–8)||||17,448||Chase Field||38–77||W1 |- style="text-align:center; background:#fbb;" |116||August 9||@Diamondbacks||9–11||Owings (6–0)||López