|| @ Orioles || 8–3 || Guthrie (2–6) || Lannan (2–5) || || 33,107 || 21–24 |- align="center" bgcolor="ffbbbb" | 46 || May 22 || @ Orioles || 2–1 || Johnson (3–1) || Zimmermann (2–5) || Gregg (8) || 33,626 || 21–25 |- align="center" bgcolor="ffbbbb" | 47 || May 23 || @ Brewers || 11 – 3 || Gallardo (6–2) || Gorzelanny (2–4) || || 22,906 || 21–26 |- align="center" bgcolor="ffbbbb" | 48 || May 24 || @ Brewers || 7–6 || McClendon (2–0) || Rodríguez (1–1) || Axford (13) || 24,722 || 21–27 |- align="center" bgcolor="ffbbbb" | 49 || May 25 || @ Brewers || 6–4 || Greinke (3–1) || Marquis (5–2) || Loe (1) || 34,419 || 21–28 |- align="center" bgcolor="bbffbb" | 50 || May 27 || Padres || 2–1 || Storen (4–1) || Adams (2–1) || || 21,024 || 22–28 |- align="center" bgcolor="ffbbbb" | 51 || May 28 || Padres || 2–1 || Stauffer (1–3) || Zimmermann (2–6) || Bell (11) || 19,159 || 22–29 |- align="center" bgcolor="ffbbbb" | 52 || May 29 || Padres || 5–4 || Gregerson (2–1) || Storen (4–2) || Bell (12) || 23,169 || 22–30 |- align="center" bgcolor="ffbbbb" | 53 || May 30 || Phillies || 5–4 || Halladay (7–3) || Burnett (0–2) || Madson (12) || 34,789 || 22–31 |- align="center" bgcolor="bbffbb" | 54 || May 31 || Phillies || 10 – 2 || Marquis (6–2) || Lee (4–5) || || 21,017 || 23–31 |- |- align="center" bgcolor="bbffbb" | 55 || June 1 || Phillies || 2–1 || Lannan (3–5) || Oswalt (3–3) || Storen (10) || 24,495 || 24–31 |- align="center" bgcolor="bbffbb" | 56 || June 2 || @ Diamondbacks || 6–1 || Zimmermann (3–6) || Duke (1–1) || Storen (11) || 17,810 || 25–31 |- align="center" bgcolor="ffbbbb" | 57 || June 3 || @ Diamondbacks || 4–0 || Collmenter (4–1) || Maya (0–1) || || 20,332 || 25–32 |- align="center" bgcolor="ffbbbb" | 58 || June 4 || @ Diamondbacks || 2–0 || Saunders (3–5) || Hernández (3–7) || Putz (17) || 26,199 || 25–33 |- align="center" bgcolor="bbffbb" | 59 || June 5 || @ Diamondbacks || 9–4 (11) || Burnett (1–2) || Paterson (0–1) || || 23,129 || 26–33 |- align="center" bgcolor="ffbbbb" | 60 || June 6 || @ Giants || 5–4 (13) || López (3–1) || Stammen (0–1) || || 41,180 || 26–34 |- align="center" bgcolor="bbffbb" | 61