9–3 || Verlander (2–2) || Buehrle (1–2) || || 23,537 || 10–10 |- bgcolor="bbffbb" | 21 || April 23 || White Sox || W 9–0 || Penny (1–2) || Jackson (2–2) || || 35,227 || 11–10 |- bgcolor="bbffbb" | 22 || April 24 || White Sox || W 3–0 || Scherzer (4–0) || Danks (0–3) || Valverde (5) || 17,784 || 12–10 |- bgcolor="ffbbbb" | 23 || April 26 || Mariners || L 7–3 || Hernández (3–2) || Coke (1–4) || || 18,027 || 12–11 |- bgcolor="ffbbbb" | 24 || April 27 || Mariners || L 10–1 || Bédard (1–4) || Verlander (2–3) || || 18,153 || 12–12 |- bgcolor="ffbbbb" | 25 || April 28 || Mariners || L 7–2 || Pineda (4–2) || Penny (1–3) || || 21,176 || 12–13 |- bgcolor="ffbbbb" | 26 || April 29 || @ Indians || L 9–5 || Perez (1–1) || Benoit (0–1) || || 15,568 || 12–14 |- bgcolor="ffbbbb" | 27 || April 30 || @ Indians || L 3–2 (13) || Sipp (1–0) || Villarreal (1–1) || || 26,433 || 12–15 |- |- bgcolor="ffbbbb" | 28 || May 1 || @ Indians || L 5–4 || Durbin (1–1) || Benoit (0–2) || Perez (7) || 14,164 || 12–16 |- bgcolor="ffbbbb" | 29 || May 2 || Yankees || L 5–3 || Chamberlain (2–0) || Valverde (2–1) || Rivera (11) || 22,852 || 12–17 |- bgcolor="bbffbb" | 30 || May 3 || Yankees || W 4–2 || Penny (2–3) || Sabathia (2–2) || Valverde (6) || 23,551 || 13–17 |- bgcolor="bbffbb" | 31 || May 4 || Yankees || W 4–0 || Scherzer (5–0) || García (1–2) || || 22,569 || 14–17 |- bgcolor="bbffbb" | 32 || May 5 || Yankees || W 6–3 || Porcello (2–2) || Burnett (4–2) || || 30,572 || 15–17 |- bgcolor="ffbbbb" | 33 || May 6 || @ Blue Jays || L 7–4 || Litsch (3–2) || Coke (1–5) || Francisco (2) || 19,711 || 15–18 |- bgcolor="bbffbb" | 34 || May 7 || @ Blue Jays || W 9–0 || Verlander (3–3) || Romero (2–4) || || 23,453 || 16–18 |- bgcolor="bbffbb" | 35 || May 8 || @ Blue Jays || W 5–2 || Penny (3–3) || Reyes (0–3) || Valverde (7) || 17,392 || 17–18 |- bgcolor="bbffbb" | 36 || May 9 || @ Blue Jays || W 10–5 || Scherzer (6–0) ||