|| @ Padres || 6–0 || Hudson (3–4) || Moseley (1–4) || – || 35,936 || 15–17 |- align="center" bgcolor="ffbbbb" | 33 || May 8 || @ Padres || 3–4 || Harang (5–2) || Saunders (0–4) || Bell (8) || 21,490 || 15–18 |- align="center" bgcolor="ffbbbb" | 34 || May 10 || @ Giants || 0–1 || Wilson (3–1) || Hernandez (2–1) || – || 41,039 || 15–19 |- align="center" bgcolor="ffbbbb" | 35 || May 11 || @ Giants || 3–4 || Sánchez (3–2) || Galarraga (3–3) || Wilson (12) || 41,026 || 15–20 |- align="center" bgcolor="ffbbbb" | 36 || May 12 || @ Giants || 2–3 || Cain (3–2) || Hudson (3–5) || López (1) || 41,126 || 15–21 |- align="center" bgcolor="ffbbbb" | 37 || May 13 || @ Dodgers || 3–4 || Kershaw (5–3) || Saunders (0–5) || Jansen (1) || 35,506 || 15–22 |- align="center" bgcolor="bbffbb" | 38 || May 14 || @ Dodgers || 1–0 || Collmenter (2–0) || Billingsley (2–3) || Putz (8) || 30,602 || 16–22 |- align="center" bgcolor="bbffbb" | 39 || May 15 || @ Dodgers || 4–1 || Kennedy (4–1) || Lilly (3–4) || Putz (9) || 40,654 || 17–22 |- align="center" bgcolor="ffbbbb" | 40 || May 16 || Padres || 4–8 || Richard (2–4) || Galarraga (3–4) || Adams (1) || 17,958 || 17–23 |- align="center" bgcolor="bbffbb" | 41 || May 17 || Padres || 6–1 || Hudson (4–5) || Stauffer (0–2) || || 16,365 || 18–23 |- align="center" bgcolor="bbffbb" | 42 || May 18 || Braves || 5–4 (11)|| Heilman (2–0) || Kimbrel (1–2) || – || 19,773 || 19–23 |- align="center" bgcolor="bbffbb" | 43 || May 19 || Braves || 2–1 || Collmenter (3–0) || Jurrjens (5–1) || Putz (10) || 23,413 || 20–23 |- align="center" bgcolor="bbffbb" | 44 || May 20 || Twins || 8–7 || Kennedy (5–1) || Duensing (2–4) || Paterson (1) || 27,450 || 21–23 |- align="center" bgcolor="bbffbb" | 45 || May 21 || Twins || 9–6 || Heilman (3–0) || Capps (1–3) || Putz (11) || 39,776 || 22–23 |- align="center" bgcolor="bbffbb" | 46 || May 22 || Twins || 3–2 || Hudson (5–5) || Burnett (0–3) || Putz (12) || 31,017 || 23–23 |- align="center" bgcolor="ffbbbb" | 47 || May 24 || @ Rockies || 4–12 || Reynolds (2–0) || Collmenter (3–1) || || 26,378 || 23–24 |- align="center" bgcolor="bbffbb" | 48 ||