12 || April 13 || @ Padres || FSO || L 2–3 || Bell (1–0) || Masset (0–3) || || 17,057 || 8–4 || |- align="center" bgcolor="ffbbbb" | 13 || April 15 || Pirates || FSO || L 1–6 || Morton (2–0) || Arroyo (2–1) || || 21,312 || 8–5 || |- align="center" bgcolor="bbffbb" | 14 || April 16 || Pirates || FSO || W 11–2 || Leake (2–0) || McDonald (0–1) || || 26,418 || 9–5 || |- align="center" bgcolor="ffbbbb" | 15 || April 17 || Pirates || FSO || L 6–7 || Resop (1–0) || Ondrusek (2–1) || Hanrahan (5) || 32,105 || 9–6 || |- align="center" bgcolor="ffbbbb" | 16 || April 18 || Pirates || FSO || L 3–9 || Correia (3–1) || Wood (1–2) || || 12,777 || 9–7 || |- align="center" bgcolor="ffbbbb" | 17 || April 19 || Diamondbacks || FSO || L 4–5 || Galarraga (3–0) || LeCure (0–1) || Putz (4) || 12,994 || 9–8 || |- align="center" bgcolor="ffbbbb" | 18 || April 20 || Diamondbacks || FSO || L 1–3 || Kennedy (2–1) || Arroyo (2–2) || Putz (5) || 14,915 || 9–9 || |- align="center" bgcolor="bbffbb" | 19 || April 21 || Diamondbacks || MLBN || W 7–4 || Leake (3–0) || Hudson (0–4) || || 17,319 || 10–9 || |- align="center" bgcolor="ffbbbb" | 20 || April 22 || @ Cardinals || FSO || L 2–4 || McClellan (3–0) || Maloney (0–1) || Boggs (2) || 40,327 || 10–10 || |- align="center" bgcolor="bbffbb" | 21 || April 23 || @ Cardinals || Fox || W 5–3 || Chapman (1–0) || Batista (1–1) || Cordero (3) || 41,877 || 11–10 || |- align="center" bgcolor="ffbbbb" | 22 || April 24 || @ Cardinals || ESPN || L 0–3 || Westbrook (2–2) || Vólquez (2–1) || Boggs (3) || 38,201 || 11–11 || |- align="center" bgcolor="bbffbb" | 23 || April 25 || @ Brewers || FSO || W 9–5 || Arroyo (3–2) || Narveson (1–1) || || 35,794 || 12–11 || |- align="center" bgcolor="ffbbbb" | 24 || April 26 || @ Brewers || FSO || L 2–3 || Loe (2–1) || Ondrusek (2–2) || Axford (5) || 37,062 || 12–12 || |- align="center" bgcolor="bbffbb" | 25 || April 27 || @ Brewers || FSO || W 7–6 (10) || Chapman (2–0) || Mitre (0–1) || Cordero (4) || 33,848 || 13–12 || |- align="center"