(6–13) || Hellickson (11–9) || Valverde (38) || 14,069 || 71–59 |- bgcolor="bbffbb" | 131 || August 26 || @ Twins || W 8–1 || Porcello (12–8) || Diamond (0–2) || || 38,918 || 72–59 |- bgcolor="bbffbb" | 132 || August 27 || @ Twins || W 6–4 || Verlander (20–5) || Pavano (6–11) || Valverde (39) || 40,179 || 73–59 |- bgcolor="ffbbbb" | 133 || August 28 || @ Twins || L 11–4 || Duensing (9–13) || Penny (9–10) || || 39,130 || 73–60 |- bgcolor="ffbbbb" | 134 || August 29 || Royals || L 9–5 || Hochevar (9–10) || Scherzer (13–8) || Wood (1) || 32,423 || 73–61 |- bgcolor="bbffbb" | 135 || August 30 || Royals || W 2–1 (10) || Benoit (4–3) || Crow (3–4) || || 34,866 || 74–61 |- bgcolor="bbffbb" | 136 || August 31 || Royals || W 5–4 || Schlereth (2–1) || Wood (5–2) || Valverde (40) || 33,572 || 75–61 |- |- bgcolor="ffbbbb" | 137 || September 1 || Royals || L 11–8 || Crow (4–4) || Coke (2–9) || Soria (25) || 39,084 || 75–62 |- bgcolor="bbfbbb" | 138 || September 2 || White Sox || W 8–1 || Verlander (21–5) || Danks (6–10) || || 42,352 || 76–62 |- bgcolor="bbffbb" | 139 || September 3 || White Sox || W 9–8 || Marte (1–0) || Santos (3–4) || || 40,635 || 77–62 |- bgcolor="bbffbb" | 140 || September 4 || White Sox || W 18–2 || Scherzer (14–8) || Buehrle (11–7) || || 42,671 || 78–62 |- bgcolor="bbffbb" | 141 || September 5 || @ Indians || W 4–2 || Fister (7–13) || Jiménez (8–11) || Valverde (41) || 39,824 || 79–62 |- bgcolor="bbffbb" | 142 || September 6 || @ Indians || W 10–1 || Porcello (13–8) || Carmona (6–14) || || 27,544 || 80–62 |- bgcolor="bbffbb" | 143 || September 7 || @ Indians || W 8–6 || Verlander (22–5) || Masterson (11–9) || Valverde (42) || 16,783 || 81–62 |- bgcolor="bbffbb" | 144 || September 9 || Twins || W 8–4 || Penny (10–10) || Slowey (0–5) || || 35,996 || 82–62 |- bgcolor="bbffbb" | 145 || September 10 || Twins || W 3–2 || Alburquerque (6–1) || Perkins (4–4) || || 38,567 || 83–62 |- bgcolor="bbffbb" | 146 || September 11 || Twins || W 2–1 || Fister (8–13) || Diamond (1–4) || Valverde (43)