(22) || 38,048 || 43–56 || |- style="text-align:center; background:#fbb;" | 100 || July 23 || @ Red Sox || 1–3 || Beckett (9–3) || Beavan (1–2) || Papelbon (23) || 38,115 || 43–57 || |- style="text-align:center; background:#fbb;" | 101 || July 24 || @ Red Sox || 8–12 || Wakefield (6–3) || Pineda (8–7) || || 37,650 || 43–58 || |- style="text-align:center; background:#fbb;" | 102 || July 25 || @ Yankees || 3–10 || García (9–7) || Vargas (6–9) || || 44,365 || 43–59 || |- style="text-align:center; background:#fbb;" | 103 || July 26 || @ Yankees || 1–4 || Sabathia (15–5) || Fister (3–12) || Rivera (26) || 46,132 || 43–60 || |- style="text-align:center; background:#bfb;" | 104 || July 27 || @ Yankees || 9–2 || Hernández (9–9) || Hughes (1–3) || || 47,090 || 44–60 || |- style="text-align:center; background:#fbb;" | 105 || July 29 || Rays || 0–8 || Niemann (5–4) || Bédard (4–7) || || 26,570 || 44–61 || |- style="text-align:center; background:#bfb;" | 106 || July 30 || Rays || 3–2 || Pineda (9–7) || Cobb (3–1) || League (24) || 24,985 || 45–61 || |- style="text-align:center; background:#fbb;" | 107 || July 31 || Rays || 1–8 || Hellickson (10–7) || Vargas (6–10) || || 20,382 || 45–62 || |- |- style="text-align:center; background:#bfb;" | 108 || August 1 || Athletics || 8–4 || Beavan (2–2) || Cahill (9–10) || || 23,335 || 46–62 || |- style="text-align:center; background:#bfb;" | 109 || August 2 || Athletics || 4–2 || Hernández (10–9) || Harden (2–2) || League (25) || 22,576 || 47–62 || |- style="text-align:center; background:#bfb;" | 110 || August 3 || Athletics || 7–4 || Furbush (2–3) || Gonzalez (9–9) || League (26) || 29,691 || 48–62 || |- style="text-align:center; background:#fbb;" | 111 || August 5 || @ Angels || 0–1 (10) || Walden (3–3) || Cortes (0–1) || || 38,727 || 48–63 || |- style="text-align:center; background:#bfb;" | 112 || August 6 || @ Angels || 5–1 || Beavan (3–2) || Chatwood (6–8) || || 42,017 || 49–63 || |- style="text-align:center; background:#fbb;" | 113 || August 7 || @ Angels || 1–2 || Santana (8–8) || Hernández (10–10) || Walden (25) || 38,823 || 49–64 || |- style="text-align:center; background:#fbb;" | 114 || August 8 || @ Rangers || 2–9 || Harrison (10–8) || Furbush (2–4) || || 27,771 || 49–65 || |- style="text-align:center; background:#fbb;" | 115 || August 9 ||