(2–5)||Putz (27)||17,814||Chase Field||38–78||L1 |- style="text-align:center; background:#fbb;" |117||August 10||@Diamondbacks||3–6||Collmenter (7–7)||Sosa (0–1)||Hernandez (10)||18,628||Chase Field||38–79||L2 |- style="text-align:center; background:#fbb;" |118||August 11||@Diamondbacks||5–8 (10)||Putz (2–2)||Fulchino (1–4)||||18,418||Chase Field||38–80||L3 |- style="text-align:center; background:#fbb;" |119||August 12||@Dodgers||0–1 (10)||Lindblom (1–0)||Carpenter (0–2)||||33,642||Dodger Stadium||38–81||L4 |- style="text-align:center; background:#fbb;" |120||August 13||@Dodgers||1–6||Kershaw (14–5)||W. Rodríguez (8–9)||||36,111||Dodger Stadium||38–82||L5 |- style="text-align:center; background:#fbb;" |121||August 14||@Dodgers||0–7||Kuroda (8–14)||Lyles (1–7)||||36,339||Dodger Stadium||38–83||L6 |- style="text-align:center; background:#fbb;" |122||August 15||Cubs||3–4||López (4–3)||Sosa (0–2)||Wood (1)||20,138||Minute Maid Park||38–84||L7 |- style="text-align:center; background:#bfb;" |123||August 16||Cubs||6–5||A. Rodríguez (1–4)||Mármol (2–4)||||23,736||Minute Maid Park||39–84||W1 |- style="text-align:center; background:#bfb;" |124||August 17||Cubs||4–3||Norris (6–8)||Coleman (2–5)||Melancon (12)||24,054||Minute Maid Park||40–84||W2 |- style="text-align:center; background:#bfb;" |125||August 19||Giants||6–0||W. Rodríguez (9–9)||Vogelsong (10–3)||||26,259||Minute Maid Park||41–84||W3 |- style="text-align:center; background:#bfb;" |126||August 20||Giants||7–5||Lyles (2–7)||Bumgarner (7–12)||Melancon (13)||29,046||Minute Maid Park||42–84||W4 |- style="text-align:center; background:#fbb;" |127||August 21||Giants||4–6 (11)||Affeldt (2–2)||Melancon (6–4)||Ramírez (3)||25,838||Minute Maid Park||42–85||L1 |- style="text-align:center; background:#fbb;" |128||August 22||@Rockies||5–9||Chacín (10–10)||Myers (3–13)||Betancourt (3)||27,166||Coors Field||42–86||L1 |- style="text-align:center; background:#fbb;" |129||August 23||@Rockies||6–8||Belisle (8–4)||F. Rodriguez (2–2)||Brothers (1)||31,179||Coors Field||42–87||L2 |- style="text-align:center; background:#fbb;" |130||August 24||@Rockies||6–7 (10)||Belisle (9–4)||A. Rodríguez (1–5)||||30,333||Coors Field||42–88||L3 |- style="text-align:center; background:#bfb;" |131||August 25||@Giants||3–1||Sosa (1–2)||Vogelsong (10–4)||Melancon (14)||41,115||AT&T Park||43–88||W1 |- style="text-align:center; background:#fbb;" |132||August 26||@Giants||1–2||Bumgarner (8–12)||Happ (4–15)||Casilla (2)||41,438 ||AT&T Park||43–89||L1 |- style="text-align:center; background:#fbb;" |133||August 27||@Giants||1–2 (10)||Affeldt (3–2)||F. Rodriguez (2–3)||||42,318||AT&T Park||43–90||L2 |- style="text-align:center; background:#bfb;" |134||August 28||@Giants||4–3 (11)||Melancon (7–4)||Ramírez (2–3)||Carpenter (1)||41,681||AT&T Park||44–90||W1 |- style="text-align:center; background:#bfb;" |135||August 29||Pirates||7–4||W. Rodríguez (10–9)||Grilli (1–1)||Melancon (15)||19,250||Minute Maid Park||45–90||W2 |- style="text-align:center; background:#bfb;" |136||August 30||Pirates||8–2||Sosa (2–2)||Morton (9–8)||||21,750||Minute Maid Park||46–90||W3 |- style="text-align:center; background:#bfb;" |137||August 31||Pirates||2–0||Happ (5–15)||McDonald (8–7)||Melancon (16)||22,918||Minute Maid Park||47–90||W4 |- |- style="text-align:center; background:#fbb;" |138||September 2||Brewers||2–8||Greinke (14–5)||A. Rodríguez (1–6)||||20,045||Minute Maid Park||47–91||L1 |- style="text-align:center; background:#fbb;" |139||September 3||Brewers||2–8||Narveson (10–6)||Norris (6–9)||||24,982||Minute Maid Park||47–92||L2 |- style="text-align:center; background:#fbb;" |140||September 4||Brewers||0–4||Marcum (12–5)||W. Rodríguez (10–10)||||21,976||Minute Maid Park||47–93||L3 |- style="text-align:center; background:#fbb;" |141||September 5||@Pirates||1–3||McDonald (9–7)||Sosa (2–3)||Hanrahan (35)||13,366||PNC Park||47–94||L4 |- style="text-align:center; background:#bfb;" |142||September 6||@Pirates||4–1||Myers (4–13)||Lincoln (1–2)||Melancon (17)||9,840||PNC Park||48–94||W1 |- style="text-align:center; background:#fbb;" |143||September 7||@Pirates||4–5||Watson (2–2)||López (2–6)||Hanrahan (36)||12,330||PNC Park||48–95||L1 |- style="text-align:center; background:#fbb;" |144||September 9||@Nationals||3–4||Clippard (3-0)||Harrell (0-1)||||18,307||Nationals Park||48-96||L2 |- style="text-align:center; background:#bfb;" |145||September 10||@Nationals||9–3||W. Rodríguez (11–10)||Lannan (9–12)||||30,935||Nationals Park||49-96||W1 |- style="text-align:center; background:#fbb;" |146||September 11||@Nationals||2–8||Gorzelanny (3–6)||Sosa (2–4)||||24,238||Nationals Park||49-97||L1 |- style="text-align:center; background:#bfb;" |147||September 12||Phillies||5–1||Myers (5–13)||Oswalt (7–9)||||22,231||Minute Maid Park||50-97||W1 |- style="text-align:center; background:#bfb;" |148||September 13||Phillies||5–2||Happ (6–15)||Hamels (14–8)||||24,302||Minute Maid Park||51-97||W2 |- style="text-align:center; background:#fbb;" |149||September 14||Phillies||0–1||Halladay (18–5)||Norris (6–10)||||20,027||Minute Maid Park||51-98||L1 |- style="text-align:center; background:#fbb;" |150||September 16||@Cubs||3–4||Samardzija (7–4)||Carpenter (0–3)||||35,318||Wrigley Field||51-99||L2 |- style="text-align:center; background:#fbb;" |151||September 17||@Cubs||1–2||López (6–6)||Sosa (2-5)||Marshall (5)||39,377||Wrigley Field||51-100||L3 |- style="text-align:center; background:#bfb;" |152||September 18||@Cubs||3–2||Myers (6–13)||Dempster (10–13)||Melancon (18)||36,250||Wrigley Field||52-100||W1 |- style="text-align:center; background:#bfb;" |153||September 19||@Reds||3–2||Carpenter (1–3)||Masset (3–6)||Melancon (19)||21,168||Great American Ball Park||53-100||W2 |- style="text-align:center; background:#fbb;" |154||September 20||@Reds||4–6||Bailey (9–7)||Norris (6–11)||Cordero (34)||23,847||Great American Ball Park||53-101||L1 |- style="text-align:center; background:#fbb;" |155||September 21||@Reds||0–2||Arroyo (9–12)||W. Rodríguez (11–11)||||20,875||Great American Ball Park||53-102||L2 |- style="text-align:center; background:#bfb;" |156||September 22||Rockies||9–6||Sosa (3-5)||White (3–3)||Melancon (20)||20,773||Minute Maid Park||54-102||W1 |- style="text-align:center; background:#bfb;" |157||September 23||Rockies||11–2||Myers (7–13)||Pomeranz (1-1)||||22,467||Minute Maid Park||55-102||W2 |- style="text-align:center; background:#fbb;" |158||September 24||Rockies||2–4 (13)||Reynolds (1-2)||Lyles