bgcolor="#bbffbb" | 34 || May 7 || Yankees || 7–5 || Arthur Rhodes (1–1) || Boone Logan (1–2) || Neftalí Feliz (6) || 49,574 || 18–16 || |- align="center" bgcolor="#ffbbbb" | 35 || May 8 || Yankees || 5–12 || CC Sabathia (3–2) || Arthur Rhodes (1–2) || || 48,057 || 18–17 || |- align="center" bgcolor="#ffbbbb" | 36 || May 9 || Athletics || 2–7 || Trevor Cahill (6–0) || C. J. Wilson (4–2) || || 24,375 || 18–18 || |- align="center" bgcolor="#bbffbb" | 37 || May 10 || Athletics || 7–2 || Colby Lewis (3–4) || Brett Anderson (2–3) || || 31,655 || 19–18 || |- align="center" bgcolor="#bbbbbb" | || May 11 || Athletics || colspan=7| Postponed (rain); Makeup: July 7 |- align="center" bgcolor="#bbffbb" | 38 || May 13 || Angels || 4–1 || Alexi Ogando (4–0) || Jered Weaver (6–3) || Neftalí Feliz (7) || 45,995 || 20–18 || |- align="center" bgcolor="#ffbbbb" | 39 || May 14 || Angels || 2–3 || Scott Downs (1–0) || Darren Oliver (1–4) || Jordan Walden (7) || 47,663 || 20–19 || |- align="center" bgcolor="#bbffbb" | 40 || May 15 || Angels || 5–4 || Mark Lowe (1–0) || Rich Thompson (1–2) || Neftalí Feliz (8) || 48,284 || 21–19 || |- align="center" bgcolor="#bbffbb" | 41 || May 16 || @ White Sox || 4–0 || Colby Lewis (4–4) || Edwin Jackson (3–5) || || 23,048 || 22–19 || |- align="center" bgcolor="#ffbbbb" | 42 || May 17 || @ White Sox || 3–4 || Jesse Crain (1–1) || Cody Eppley (1–1) || Sergio Santos (6) || 22,437 || 22–20 || |- align="center" bgcolor="#bbffbb" | 43 || May 18 || @ Royals || 5–4 || Arthur Rhodes (2–2) || Jeremy Jeffress (1–1) || Mark Lowe (1) || 13,789 || 23–20 || |- align="center" bgcolor="#ffbbbb" | 44 || May 19 || @ Royals || 1–2 (10) || Greg Holland (1–0) || Darren Oliver (1–5) || || 12,355 || 23–21 || |- align="center" bgcolor="#ffbbbb" | 45 || May 20 || @ Phillies || 2–3 || Roy Halladay (6–3) ||C. J. Wilson (4–3) || Ryan Madson (8) || 45,358 || 23–22 || |- align="center" bgcolor="#ffbbbb" | 46 || May 21 || @ Phillies || 0–2 || Cliff Lee (3–4) || Colby Lewis (4–5) || Ryan Madson (9) || 45,604 || 23–23 || |- align="center" bgcolor="#bbffbb" | 47 || May 22 || @ Phillies || 2–0 ||