5–4 || Pavano (8–11) || Danks (6–11) || Nathan (13) || 38,359 || 59–84 |- style="text-align:center; background:#fbb;" | 144 || September 9 || @ Tigers || 8–4 || Penny (10–10) || Slowey (0–5) || || 35,996 || 59–85 |- style="text-align:center; background:#fbb;" | 145 || September 10 || @ Tigers || 3–2 || Alburquerque (6–1) || Perkins (4–4) || || 38,567 || 59–86 |- style="text-align:center; background:#fbb;" | 146 || September 11 || @ Tigers || 2–1 || Fister (8–13) || Diamond (1–4) || Valverde (43) || 36,972 || 59–87 |- style="text-align:center; background:#fbb;" | 147 || September 13 || @ Royals || 4–0 || Chen (11–7) || Pavano (8–12) || || 25,253 || 59–88 |- style="text-align:center; background:#fbb;" | 148 || September 14 || @ Royals || 7–3 || Hochevar (11–11) || Hendriks (0–2) || Holland (3) || 19,076 || 59–89 |- style="text-align:center; background:#fbb;" | 149 || September 16 || Indians || 7–6 || Jiménez (4–2) || Slowey (0–6) || C. Perez (33) || 37,942 || 59–90 |- style="text-align:center; background:#fbb;" | 150 || September 17 || Indians || 10–4 || Gómez (4–2) || Swarzak (3–7) || || 38,805 || 59–91 |- style="text-align:center; background:#fbb;" | 151 || September 18 || Indians || 6–5 || Masterson (12–10) || Pavano (8–13) || C. Perez (34) || 37,012 || 59–92 |- style="text-align:center; background:#fbb;" | 152 || September 19 || @ Yankees || 6–4 || Wade (6–1) || Diamond (1–5) || Rivera (43) || 40,045 || 59–93 |- style="text-align:center; background:#fbb;" | 153 || September 20 || Mariners || 5–4 || Vargas (9–13) || Duensing (9–14) || League (35) || 35,995 || 59–94 |- style="text-align:center; background:#fbb;" | 154 || September 21 || Mariners || 5–4 || Jimenez (1–0) || Slowey (0–7) || League (36) || 36,263 || 59–95 |- style="text-align:center; background:#bfb;" | 155 || September 22 || Mariners || 3–2 || Nathan (2–1) || Delabar (1–1) || || 37,466 || 60–95 |- style="text-align:center; background:#fbb;" | 156 || September 23 || @ Indians || 6–5 || C. Perez (4–7) || Capps (4–7) || || 36,807 || 60–96 |- style="text-align:center; background:#fbb;" | 157 || September 24 || @ Indians || 8–2 || Putnam (1–1) || Liriano (9–10) || || 26,197 || 60–97 |- style="text-align:center; background:#fbb;" | 158 || September 24 || @ Indians || 7–6 || Hagadone (1–0) || Mijares (0–2) || || 30,748 || 60–98 |- style="text-align:center; background:#bfb;" | 159 || September 25 || @ Indians || 6–4 (10) ||