|- bgcolor="ffbbbb" | 32 || May 6|| Oakland Athletics || L 2–3 || Gonzalez (4–2) || O'Sullivan (1–2) || Fuentes (8) || 30,690 || 17–15 |- bgcolor="bbffbb" | 33 || May 7|| Oakland Athletics || W 4–3 || Soria (2–0) || McCarthy (1–3) || || 25,828 || 18–15 |- bgcolor="ffbbbb" | 34 || May 8|| Oakland Athletics || L 2–5 || Ross (2–2) || Francis (0–4) || Fuentes (9) || 22,435 || 18–16 |- bgcolor="ffbbbb" | 35 || May 10|| @ New York Yankees || L 1–3 || García (2–2) || Davies (1–5) || Rivera (13) || 41,275 || 18–17 |- bgcolor="bbffbb" | 36 || May 11|| @ New York Yankees || W 4–3 (11) || Soria (3–0) || Carlyle (0–1) || Coleman (1) || 40,164 || 19–17 |- bgcolor="bbffbb" | 37 || May 12|| @ New York Yankees || W 11–5 || O'Sullivan (2–2) || Nova (3–3) || || 41,790 || 20–17 |- bgcolor="ffbbbb" | 38 || May 13|| @ Detroit Tigers || L 1–3 || Verlander (4–3) || Hochevar (3–4) || Valverde (9) || 33,641 || 20–18 |- bgcolor="ffbbbb" | 39 || May 14|| @ Detroit Tigers || L 0–3 || Penny (4–3) || Francis (0–5) || Valverde (10) || 37,647 || 20–19 |- bgcolor="bbbbbb" | – || May 15|| @ Detroit Tigers || -|| – || – || – || – || - |- bgcolor="ffbbbb" | 40 || May 16|| Cleveland Indians || L 1–19 || Tomlin (5–1) || Davies (1–6) || || 12,242 || 20–20 |- bgcolor="ffbbbb" | 41 || May 17|| Cleveland Indians || L 3–7 || Carrasco (2–2) || O'Sullivan (2–3) || || 17,712 || 20–21 |- bgcolor="ffbbbb" | 42 || May 18|| Texas Rangers || L 4–5 (11) || Rhodes (2–2) || Jeffress (1–1) || Lowe (1) || 13,789 || 20–22 |- bgcolor="bbffbb" | 43 || May 19|| Texas Rangers || W 2–1 (10) || Holland (1–0) || Oliver (1–5) || || 12,355 || 21–22 |- bgcolor="bbffbb" | 44 || May 20|| St. Louis Cardinals || W 3–0 || Francis (1–5) || Carpenter (1–4) || Soria (7) || 26,816 || 22–22 |- bgcolor="ffbbbb" | 45 || May 21|| St. Louis Cardinals || L 0–3 || Westbrook (4–3) || Collins (2–2) || Salas (6) || 32,229 || 22–23 |- bgcolor="ffbbbb" | 46 || May 22|| St. Louis Cardinals || L 8–9 (10) || Motte (2–1) || Coleman (0–1) || Salas (7) || 28,195 ||