6–0 || |- align="center" bgcolor="#bbbbbb" | || April 8 || @ Orioles || colspan=7| Postponed (rain); Makeup: April 9 as part of a doubleheader |- align="center" bgcolor="#ffbbbb" | 7 || April 9 (Game 1) || @ Orioles || 0–5 || Zach Britton (2–0) || Colby Lewis (1–1) || || 36,243 || 6–1 || |- align="center" bgcolor="#bbffbb" | 8 || April 9 (Game 2) || @ Orioles || 13–1 || Matt Harrison (2–0) || Jake Arrieta (1–1) || || 36,243 || 7–1 || |- align="center" bgcolor="#bbffbb" | 9 || April 10 || @ Orioles || 3–0 || Derek Holland (2–0) || Jeremy Guthrie (1–1) || Neftalí Feliz (3) || 21,452 || 8–1 || |- align="center" bgcolor="#bbffbb" | 10 || April 11 || @ Tigers || 2–0 || Alexi Ogando (2–0) || Justin Verlander (1–1) || Neftalí Feliz (4) || 18,724 || 9–1 || |- align="center" bgcolor="#ffbbbb" | 11 || April 12 || @ Tigers || 4–5 || José Valverde (1–0) || Darren O'Day (0–1) || || 20,609 || 9–2 || |- align="center" bgcolor= "#ffbbbb" | 12 || April 13 || @ Tigers || 2–3 || José Valverde (2–0) || Darren Oliver (1–1) || || 20,526 || 9–3 || |- align="center" bgcolor="#bbffbb" | 13 || April 15 || @ Yankees || 5–3 || Matt Harrison (3–0) || Iván Nova (1–1) || Neftalí Feliz (5) || 40,814 || 10–3 || |- align="center" bgcolor="#ffbbbb" | 14 || April 16 || @ Yankees || 2–5 || Freddy García (1–0) || Derek Holland (2–1) || Mariano Rivera (6) || 41,876 || 10–4 || |- align="center" bgcolor="#ffbbbb" | 15 || April 17 || @ Yankees || 5–6 || Rafael Soriano (1–0) || Arthur Rhodes (0–1) || Mariano Rivera (7) || 40,811 || 10–5 || |- align="center" bgcolor="#bbffbb" | 16 || April 18 || Angels || 7–1 || C. J. Wilson (2–0) || Ervin Santana (0–2) || || 30,799 || 11–5 || |- align="center" bgcolor="#ffbbbb" | 17 || April 19 || Angels || 4–15 || Matt Palmer (1–0) || Colby Lewis (1–2) || || 22,450 || 11–6 || |- align="center" bgcolor="#ffbbbb" | 18 || April 20 || Angels || 1–4 || Jered Weaver (5–0) || Matt Harrison (3–1) || || 31,967 || 11–7 || |- align="center" bgcolor="#bbffbb" | 19 || April 22 || Royals || 11–6 || Derek Holland (3–1) || Jeff Francis (0–2) || || 45,769 || 12–7 || |- align="center" bgcolor="#bbffbb" | 20 || April 23