|| Dunn (2–1) || Sánchez (1–1) || Núñez (11) || 34,324 || 19–10 |- align="center" bgcolor="ffbbbb" | 30 || May 5 || @ Cardinals || 3–6 || Motte (1–0) || Johnson (3–1) || Sánchez (3) || 38,509 || 19–11 |- align="center" bgcolor="ffbbbb" | 31 || May 6 || Nationals || 2–3 (10) || Storen (2–1) || Dunn (2–2) || Burnett (4) || 15,325 || 19–12 |- align="center" bgcolor="ffbbbb" | 32 || May 7 || Nationals || 2–5 || Gorzelanny (2–2) || Volstad (2–2) || Storen (7) || 17,409 || 19–13 |- align="center" bgcolor="bbffbb" | 33 || May 8 || Nationals || 8–0 || Sánchez (2–1) || Hernández (3–4) || || 10,523 || 20–13 |- align="center" bgcolor="ffbbbb" | 34 || May 9 || Phillies || 4–6 || Blanton (1–1) || Vázquez (2–3) || Madson (4) || 11,444 || 20–14 |- align="center" bgcolor="bbffbb" | 35 || May 10 || Phillies || 2–1 || Dunn (3–2) || Halladay (5–2)|| Núñez (12) || 21,955 || 21–14 |- align="center" bgcolor="ffbbbb" | 36 || May 11 || Phillies || 3–5 || Kendrick (3–2) || Núñez (0–1) || Madson (5) || 18,504 || 21–15 |- align="center" bgcolor="bbffbb" | 37 || May 13 || @ Nationals || 6–5 (11) || Mujica (4–1) || Broderick (0–1) || Núñez (13) || 19,503 || 22–15 |- align="center" bgcolor="bbffbb" | 38 || May 14 || @ Nationals || 1–0 || Sánchez (3–1) || Hernández (3–5) || Núñez (14) || 22,497 || 23–15 |- align="center" bgcolor="ffbbbb" | 39 || May 15 || @ Nationals || 4–8 || Marquis (5–1) || Vázquez (2–4) || || 18,356 || 23–16 |- align="center" bgcolor="bbffbb" | 40 || May 16 || @ Mets || 2–1 (11)|| Badenhop (1–0) || Igarashi (0–1) || Núñez (15) || 23,721 || 24–16 |- align="center" bgcolor="bbbbbb" | – || May 17 || @ Mets ||colspan=6| Postponed (rain); Makeup: July 18 |- align="center" bgcolor="ffbbbb" | 41 || May 18 || Cubs || 5–7 || Samardzija (3–0) || Mujica (4–2) || Mármol (9) || 14,422 || 24–17 |- align="center" bgcolor="ffbbbb" | 42 || May 19 || Cubs || 1–5 || Coleman (2–3) || Volstad (2–3) || || 16,345 || 24–18 |- align="center" bgcolor="bbffbb" | 43 || May 20 || Rays || 5–3 || Dunn (4–2) || Peralta (1–3) || Núñez (16) || 18,111 || 25–18 |- align="center" bgcolor="bbffbb" | 44 || May 21 || Rays || 5–3 || Vázquez (3–4) || Price (5–4) || Núñez