| 9 || April 10 || @ Mariners || 6–4 || Tomlin (2–0) || Bédard (0–2) || C. Perez (4) || 21,128 || 7–2 |- style="text-align:center; background:#bfb;" | 10 || April 11 || @ Angels || 4–0 || Talbot (1–0) || Chatwood (0–1) || || 32,864 || 8–2 |- style="text-align:center; background:#fbb;" | 11 || April 12 || @ Angels || 2–0 || Haren (3–0) || Carmona (0–2) || || 43,529 || 8–3 |- style="text-align:center; background:#fbb;" | 12 || April 13 || @ Angels || 4–3 (12) || Takahashi (1–0) || Durbin (0–1) || || 31,049 || 8–4 |- style="text-align:center; background:#bfb;" | 13 || April 15 || Orioles || 8–2 || Masterson (3–0) || Britton (2–1) || || 16,346 || 9–4 |- style="text-align:center; background:#bfb;" | 14 || April 16 || Orioles || 8–3 || Tomlin (3–0) || Guthrie (1–2) || || 10,714 || 10–4 |- style="text-align:center; background:#bfb;" | 15 || April 17 || Orioles || 4–2 || Carmona (1–2) || Bergesen (0–2) || C. Perez (5) || 13,017 || 11–4 |- style="text-align:center; background:#bfb;" | 16 || April 18 || @ Royals || 7–3 (10) || Smith (1–0) || Collins (1–1) || || 12,214 || 12–4 |- style="text-align:center; background:#fbb;" | 17 || April 19 || @ Royals || 5–4 || Chen (3–0) || Gómez (0–1) || Soria (5) || 10,506 || 12–5 |- style="text-align:center; background:#bfb;" | 18 || April 20 || @ Royals || 7–5 || Masterson (4–0) || Hochevar (2–2) || C. Perez (6) || 10,080 || 13–5 |- style="text-align:center; background:#fbb;" | 19 || April 21 || @ Royals || 3–2 || Crow (2–0) || C. Perez (0–1) || || 9,279 || 13–6 |- style="text-align:center; background:#bbb;" | || April 22 || @ Twins || colspan=6 | Postponed (rain); Makeup: July 18 (Game 1) |- style="text-align:center; background:#fbb;" | 20 || April 23 || @ Twins || 10–3 || Duensing (2–0) || Carmona (1–3) || || 39,459 || 13–7 |- style="text-align:center; background:#fbb;" | 21 || April 24 || @ Twins || 4–3 || Pavano (2–2) || R. Pérez (2–1) || Capps (4) || 39,388 || 13–8 |- style="text-align:center; background:#bfb;" | 22 || April 26 || Royals || 9–4 || Masterson (5–0) || Hochevar (2–3) || || 9,650 || 14–8 |- style="text-align:center; background:#bfb;" | 23 || April 27 || Royals || 7–2 || Tomlin (4–0) || Francis (0–3) || || 9,722 || 15–8 |- style="text-align:center; background:#bfb;" | 24 || April 28 || Royals ||