6–3 || Wakefield (2–1) || Porcello (4–3) || || 34,046 || 25–25 |- bgcolor="bbbbbb" | – || May 28 || Red Sox || colspan=6 | Postponed (rain) – rescheduled for May 29. |- bgcolor="ffbbbb" | 51 || May 29 || Red Sox || L 4–3 || Albers (1–2) || Valverde (2–2) || Papelbon (8) || 36,285 || 25–26 |- bgcolor="bbffbb" | 52 || May 29 || Red Sox || W 3–0 || Verlander (5–3) || Beckett (4–2) || Valverde (12) || 39,873 || 26–26 |- bgcolor="bbffbb" | 53 || May 30 || Twins || W 6–5 || Alburquerque (2–1) || Burnett (1–4) || Valverde (13) || 30,198 || 27–26 |- bgcolor="bbffbb" | 54 || May 31 || Twins || W 8–7 || Alburquerque (3–1) || Dumatrait (0–1) || Benoit (2) || 22,649 || 28–26 |- |- bgcolor="bbffbb" | 55 || June 1 || Twins || W 4–2 || Porcello (5–3) || Baker (2–4) || Valverde (14) || 24,363|| 29–26 |- bgcolor="ffbbbb" | 56 || June 3 || @ White Sox || L 6–4 || Buehrle (5–4) || Oliver (0–1) || Santos (10)|| 23,095 || 29–27 |- bgcolor="bbffbb" | 57 || June 4 || @ White Sox || W 4–2 || Verlander (6–3) || Crain (2–2) || Valverde (15) || 31,037 || 30–27 |- bgcolor="bbffbb" | 58 || June 5 || @ White Sox || W 7–3 || Penny (5–4) || Peavy (2–1) || || 25,149 || 31–27 |- bgcolor="bbffbb" | 59 || June 6 || @ Rangers || W 13–7 || Scherzer (7–2) || Lewis (5–6) || || 33,921 || 32–27 |- bgcolor="bbffbb" | 60 || June 7 || @ Rangers || W 8–1 || Porcello (6–3) || Harrison (5–5) || || 35,165 || 33–27 |- bgcolor="ffbbbb" | 61 || June 8 || @ Rangers || L 7–3 || Ogando (7–0) || Coke (1–6) || || 40,388|| 33–28 |- bgcolor="bbffbb" | 62 || June 9 || Mariners || W 4–1 || Verlander (7–3) || Fister (3–7) || Valverde (16) || 22,090 || 34–28 |- bgcolor="ffbbbb" | 63 || June 10 || Mariners || L 3–2 || Ray (3–1) || Penny (5–5) || League (18) || 30,511 || 34–29 |- bgcolor="bbffbb" | 64 || June 11 || Mariners || W 8–1 || Scherzer (8–2) || Pineda (6–4) || || 38,398 || 35–29 |- bgcolor="ffbbbb" | 65 || June 12 || Mariners || L 7–3 || Hernández (7–5) || Porcello (6–4) ||