Blue Jays || 6–1 || Drabek (1–0) || Liriano (0–1) || || 27,194 || 0–2 |- style="text-align:center; background:#bfb;" | 3 || April 3 || @ Blue Jays || 4–3 ||Blackburn (1–0) || Cecil (0–1) || Nathan (1) || 35,505 || 1–2 |- style="text-align:center; background:#fbb;" | 4 || April 4 || @ Yankees || 4–3 || Nova (1–0) || Baker (0–1) || Rivera (3) || 40,311 || 1–3 |- style="text-align:center; background:#bfb;" | 5 || April 5 || @ Yankees || 5–4 (10) || Capps (1–0) || Logan (0–1) || Nathan (2) || 40,267 || 2–3 |- style="text-align:center; background:#bbb;" | || April 6 || @ Yankees || colspan=6 | Postponed (rain); Makeup: 9/19 |- style="text-align:center; background:#fbb;" | 6 || April 7 || @ Yankees || 4–3 || Burnett (2–0) || Liriano (0–2) || Rivera (4) || 41,512 || 2–4 |- style="text-align:center; background:#bfb;" | 7 || April 8 || Athletics || 2–1 || Pavano (1–1) || Anderson (0–1) || Nathan (3) || 40,714 || 3–4 |- style="text-align:center; background:#fbb;" | 8 || April 9 || Athletics || 1–0 || Gonzalez (2–0) || Blackburn (1–1) || Fuentes (2) || 39,936 || 3–5 |- style="text-align:center; background:#fbb;" | 9 || April 10 || Athletics || 5–3 || McCarthy (1–0) || Baker (0–2) || Fuentes (3) || 38,484 || 3–6 |- style="text-align:center; background:#bfb;" | 10 || April 12 || Royals || 4–3 (10) || Hughes (1–0) || Tejeda (0–1) || || 38,154 || 4–6 |- style="text-align:center; background:#fbb;" | 11 || April 13 || Royals || 10–5 || Davies (1–0) || Liriano (0–3) || Jeffress (1) || 36,286 || 4–7 |- style="text-align:center; background:#fbb;" | 12 || April 14 || @ Rays || 4–3 (10) || Farnsworth (1–0) || Capps (1–1) || || 10,042 || 4–8 |- style="text-align:center; background:#fbb;" | 13 || April 15 || @ Rays || 5–2 || Davis (1–2) || Blackburn (1–2) || Farnsworth (3) || 15,342 || 4–9 |- style="text-align:center; background:#fbb;" | 14 || April 16 || @ Rays || 4–3 || Cruz (1–0) || Nathan (0–1) || || 16,428 || 4–10 |- style="text-align:center; background:#bfb;" | 15 || April 17 || @ Rays || 4–2 || Duensing (1–0) || Hellickson (1–2) || Capps (1) || 22,426 || 5–10 |- style="text-align:center; background:#bfb;" | 16 || April 18 || @ Orioles || 5 – 3 || Liriano (1–3) || Tillman (0–2) || Capps (2) || 13,138 || 6–10 |- style="text-align:center; background:#fbb;" | 17 || April 19 || @