style="text-align:center; background:#bfb;" | 39 || May 17 || @ Royals || 7–3 || Carrasco (2–2) || O'Sullivan (2–3) || || 17,712 || 26–13 |- style="text-align:center; background:#fbb;" | 40 || May 18 || @ White Sox || 1–0 || Peavy (1–0) || Masterson (5–2) || || 18,580 || 26–14 |- style="text-align:center; background:#fbb;" | 41 || May 19 || @ White Sox || 8–2 || Floyd (5–3) || Carmona (3–4) || || 22,077 || 26–15 |- style="text-align:center; background:#bfb;" | 42 || May 20 || Reds || 5–4 || Pestano (1–0) || Bray (1–1) || C. Perez (11) || 31,622 || 27–15 |- style="text-align:center; background:#bfb;" | 43 || May 21 || Reds || 2–1 || Tomlin (6–1) || Bailey (3–1) || C. Perez (12) || 40,631 || 28–15 |- style="text-align:center; background:#bfb;" | 44 || May 22 || Reds || 12–4 || Carrasco (3–2) || Vólquez (3–2) || || 26,833 || 29–15 |- style="text-align:center; background:#bfb;" | 45 || May 23 || Red Sox || 3–2 || Smith (2–1) || Bard (1–4) || C. Perez (13) || 19,225 || 30–15 |- style="text-align:center; background:#fbb;" | 46 || May 24 || Red Sox || 4–2 || Beckett (4–1) || Carmona (3–5) || Papelbon (9) || 23,752 || 30–16 |- style="text-align:center; background:#fbb;" | 47 || May 25 || Red Sox || 14–2 || Lester (7–1) || Talbot (1–1) || || 26,408 || 30–17 |- style="text-align:center; background:#fbb;" | 48 || May 27 || @ Rays || 5–0 || Price (6–4) || Tomlin (6–2) || || 16,800 || 30–18 |- style="text-align:center; background:#bfb;" | 49 || May 28 || @ Rays || 7–3 || Carrasco (4–2) || Shields (5–3) || C. Perez (14) || 24,717 || 31–18 |- style="text-align:center; background:#fbb;" | 50 || May 29 || @ Rays || 7–0 || Hellickson (6–3) || Masterson (5–3) || || 23,898 || 31–19 |- style="text-align:center; background:#fbb;" | 51 || May 30 || @ Blue Jays || 11–1 || Reyes (1–4) || Carmona (3–6) || || 12,902 || 31–20 |- style="text-align:center; background:#bfb;" | 52 || May 31 || @ Blue Jays || 6–3 || Talbot (2–1) || Morrow (2–3) || || 14,556 || 32–20 |- |- style="text-align:center; background:#bfb;" | 53 || June 1 || @ Blue Jays || 13–9 || Tomlin (7–2) || Drabek (3–4) || || 15,397 || 33–20 |- style="text-align:center; background:#fbb;" | 54 || June 2 || Rangers || 7–4 || Kirkman (1–0) || Carrasco (4–3) || Feliz (12) || 15,336 ||