background:#fbb;" | 14 || April 16 || @ Red Sox || 4–1 || Beckett (2–1) || Reyes (0–2) || Papelbon (2) || 37,310 || 7–7 || 1½ |- style="text-align:center; background:#fbb;" | 15 || April 17 || @ Red Sox || 8–1 || Lester (1–1) || Litsch (1–1) || || 37,802 || 7–8 || 2½ |- style="text-align:center; background:#fbb;" | 16 || April 18 || @ Red Sox || 9–1 || Matsuzaka (1–2) || Romero (1–2) || || 37,916 || 7–9 || 3 |- style="text-align:center; background:#cfc;" | 17 || April 19 || Yankees || 6–5 (10) || Rauch (1–1) || Nova (1–2) || || 25,250 || 8–9 || 2 |- style="text-align:center; background:#fbb;" | 18 || April 20 || Yankees || 6–2 || Colón (1–1) || Cecil (1–2) || Soriano (1) || 26,062 || 8–10 || 3 |- style="text-align:center; background:#cfc;" | 19 || April 22 || Rays || 6–4 (11) || Rzepczynski (2–0) || Russell (1–1) || || 23,129 || 9–10 || 2½ |- style="text-align:center; background:#fbb;" | 20 || April 23 || Rays || 6–4 || Price (3–2) || Morrow (0–1) || Farnsworth (5) || 21,826 || 9–11 || 3½ |- style="text-align:center; background:#fbb;" | 21 || April 24 || Rays || 2–0 || Shields (2–1) || Romero (1–3) || || 14,456 || 9–12 || 4½ |- style="text-align:center; background:#cfc;" | 22 || April 25 || @ Rangers || 6–4 || Drabek (2–0) || Lewis (1–3) || Rauch (4) || 22,915 || 10–12 || 3½ |- style="text-align:center; background:#cfc;" | 23 || April 26 || @ Rangers || 10–3 || Litsch (2–1) || Harrison (3–2) || || 21,755 || 11–12 || 2½ |- style="text-align:center; background:#fbb;" | 24 || April 27 || @ Rangers || 7–6 || Eppley (1–0) || Dotel (1–1) || Oliver (2) || 29,322 || 11–13 || 3½ |- style="text-align:center; background:#cfc;" | 25 || April 28 || @ Rangers || 5–2 || Francisco (1–0) || Oliver (1–2) || || 24,121 || 12–13 || 3½ |- style="text-align:center; background:#cfc;" | 26 || April 29 || @ Yankees || 5–3 || Romero (2–3) || García (1–1) || Rauch (5) || 40,830 || 13–13 || 2½ |- style="text-align:center; background:#fbb;" | 27 || April 30 || @ Yankees || 5–4 || Burnett (4–1) || Drabek (2–1) || Rivera (9) || 42,460 || 13–14 || 3½ |- |- style="text-align:center; background:#fbb;" | 28 || May 1 || @ Yankees || 5–2 || Nova (2–2) || Litsch (2–2) || Rivera (10) ||