(27) || 30,087 || 66–52 || |- align="center" bgcolor="#bbffbb" | 119 || August 12 || @ Athletics || 9–1 || C. J. Wilson (11–5) || Brandon McCarthy (5–6) || || 20,288 || 67–52 || |- align="center" bgcolor="#bbffbb" | 120 || August 13 || @ Athletics || 7–1 || Colby Lewis (11–8) || Trevor Cahill (9–11) || || 25,160 || 68–52 || |- align="center" bgcolor="#bbffbb" | 121 || August 14 || @ Athletics || 7–6 || Mike Adams (1–0) || Andrew Bailey (0–3) || Neftalí Feliz (23) || 15,107 || 69–52 || |- align="center" bgcolor="#bbffbb" | 122 || August 15 || @ Angels || 8–4 || Alexi Ogando (12–5) || Bobby Cassevah (1–1) || || 36,663 || 70–52 || |- align="center" bgcolor="#bbffbb" | 123 || August 16 || @ Angels || 7–1 || Derek Holland (11–4) || Tyler Chatwood (6–9) || || 43,711 || 71–52 || |- align="center" bgcolor="#bbffbb" | 124 || August 17 || @ Angels || 4–3 || C. J. Wilson (12–5) || Ervin Santana (9–9) || Neftalí Feliz (24) || 36,581 || 72–52 || |- align="center" bgcolor="#ffbbbb" | 125 || August 18 || @ Angels || 1–2 || Horacio Ramírez (1–0) || Mike Adams (4–3) || || 41,123 || 72–53 || |- align="center" bgcolor="#bbffbb" | 126 || August 19 || @ White Sox || 7–4 || Yoshinori Tateyama (2–0) || Jake Peavy (5–6) || Neftalí Feliz (25) || 28,308 || 73–53 || |- align="center" bgcolor="#ffbbbb" | 127 || August 20 || @ White Sox || 2–3 || Jesse Crain (8–3) || Koji Uehara (1–3) || Sergio Santos (26) || 30,021 || 73–54 || |- align="center" bgcolor="#ffbbbb" | 128 || August 21 || @ White Sox || 0–10 || Gavin Floyd (11–10) || Derek Holland (11–5) || || 25,033 || 73–55 || |- align="center" bgcolor="#bbffbb" | 129 || August 22 || Red Sox || 4–0 || C. J. Wilson (13–5) || Érik Bédard (4–9) || || 33,920 || 74–55 || |- align="center" bgcolor="#ffbbbb" | 130 || August 23 || Red Sox || 5–11 || John Lackey (12–9) || Colby Lewis (11–9) || || 25,705 || 74–56 || |- align="center" bgcolor="#ffbbbb" | 131 || August 24 || Red Sox || 2–13 || Josh Beckett (11–5) || Matt Harrison (10–9) || || 30,724 || 74–57 || |- align="center" bgcolor="#ffbbbb" | 132 || August 25 || Red Sox || 0–6 || Andrew Miller (6–1) || Alexi Ogando (12–6) || || 29,729 ||