C. J. Wilson (16–6) || Josh Outman (3–5) || || 46,727 || 83–64 || |- align="center" bgcolor="#bbffbb" | 148 || September 13 || Indians || 10–4 || Matt Harrison (12–9) || Justin Masterson (11–10) || || 30,107 || 84–64 || |- align="center" bgcolor="#bbffbb" | 149 || September 14 || Indians || 9–1 || Derek Holland (14–5) || David Huff || || 38,710 || 85–64 || |- align="center" bgcolor="#bbffbb" | 150 || September 15 || Indians || 7–4 || Alexi Ogando (13–8) || Fausto Carmona || || 44,242 || 86–64 || |- align="center" bgcolor="#ffbbbb" | 151 || September 16 || @ Mariners || 0–4 || Blake Beavan (5–5) || C. J. Wilson (16–7) || || 17,607 || 86–65 || |- align="center" bgcolor="#bbffbb" | 152 || September 17 || @ Mariners || 7–6 || Colby Lewis (13–10) || Anthony Vasquez (1–4) || Neftalí Feliz (27) || 22,159 || 87–65 || |- align="center" bgcolor="#bbffbb" | 153 || September 18 || @ Mariners || 3–0 || Matt Harrison (13–9) || Félix Hernández (14–13) || Neftalí Feliz (28) || 21,479 || 88–65 || |- align="center" bgcolor="#bbffbb" | 154 || September 20 || @ Athletics || 7–2 || Derek Holland (15–5) || Rich Harden (4–4) || || 13,635 || 89–65 || |- align="center" bgcolor="#bbffbb" | 155 || September 21 || @ Athletics || 3–2 || Koji Uehara (2–3) || Grant Balfour (4–2) || Neftalí Feliz (29) || 19,589 || 90–65 || |- align="center" bgcolor="#ffbbbb" | 156 || September 22 || @ Athletics || 3–4 || Grant Balfour (5–2) || Mike Adams (4–4) || Andrew Bailey (21) || 14,090 || 90–66 || |- align="center" bgcolor="#bbffbb" | 157 || September 23 || Mariners || 5–3 || Matt Harrison (14–9) || Anthony Vasquez (1–5) || Neftalí Feliz (30) || 43,874 || 91–66 || |- align="center" bgcolor="#bbffbb" | 158 || September 24 || Mariners || 7–3 || Scott Feldman (2–1) || Félix Hernández (14–14) || || 40,242 || 92–66 || |- align="center" bgcolor="#bbffbb" | 159 || September 25 || Mariners || 12–5 || Derek Holland (16–5) || Charlie Furbush (4–10) || || 43,508 || 93–66 || |- align="center" bgcolor="#bbffbb" | 160 || September 26 || @ Angels || 4–3 || Mark Hamburger (1–0) || Dan Haren (16–10) || Neftalí Feliz (31) || 39,716 || 94–66 || |- align="center" bgcolor="#bbffbb" | 161 || September 27 || @ Angels || 10–3 || Colby Lewis (14–10) || Tyler Chatwood (6–11) || || 39,529