Dempster (0–1) || Hanrahan (1) || 41,358 || 1–0 |- style="background:#fbb;" | 2 || April 2 || @ Cubs || 3–5 || Marshall (1–0) || Meek (0–1) || Marmol (1) || 35,782 || 1–1 |- style="background:#cfc;" | 3 || April 3 || @ Cubs || 5–4 || Karstens (1–0) || Marmol (0–1) || Hanrahan (2) || 30,857 || 2–1 |- style="background:#cfc;" | 4 || April 4 || @ Cardinals || 4–3 || Morton (1–0) || Lohse (0–1) || Hanrahan (3) || 32,007 || 3–1 |- style="background:#fbb;" | 5 || April 5 || @ Cardinals || 2–3 || Batista (1–0) || Olson (0–1) || Franklin (1) || 33,666 || 3–2 |- style="background:#cfc;" | 6 || April 6 || @ Cardinals || 3–1 || Correia (2–0) || Carpenter (0–1) || Hanrahan (4) || 34,965 || 4–2 |- style="background:#fbb;" | 7 || April 7 || Rockies || 1–7 || Rogers (1–0) || Maholm (0–1) || — || 39,219 || 4–3 |- style="background:#cfc;" | 8 || April 8 || Rockies || 4–3 (14) || Olson (1–1) || Morales (0–1) || — || 29,192 || 5–3 |- style="background:#fbb;" | 9 || April 9 || Rockies || 4–6 || Belisle (1–0) || Veras (0–1) || Lindstrom (1) || 25,398 || 5–4 |- style="background:#fbb;" | 10 || April 10 || Rockies || 5–6 || Chacin (2–0) || Crotta (0–1) || Street (4) || 18,043 || 5–5 |- style="background:#bbb;" | — || April 12 || Brewers || colspan=6 | Postponed |- style="background:#fbb;" | 11 || April 13 || Brewers || 0–6 || Marcum (2–1) || Correia (2–1) || — || 8,755 || 5–6 |- style="background:#fbb;" | 12 || April 14 || Brewers || 1–4 || Wolf (1–2) || Maholm (0–2) || — || 10,517 || 5–7 |- style="background:#cfc;" | 13 || April 15 || @ Reds || 6–1 || Morton (2–0) || Arroyo (2–1) || — || 21,312 || 6–7 |- style="background:#fbb;" | 14 || April 16 || @ Reds || 2–11 || Leake (2–0) || McDonald (0–1) || — || 26,418 || 6–8 |- style="background:#cfc;" | 15 || April 17 || @ Reds || 7–6 || Resop (1–0) || Ondrusek (2–1) || Hanrahan (5) || 32,105 || 7–8 |- style="background:#cfc;" | 16 || April 18 || @ Reds || 9–3 || Correia (3–1) || Wood (1–2) || — || 12,777 || 8–8 |- style="background:#fbb;" | 17 || April 19 || @ Marlins || 0–6 || Johnson (3–0)