(2–2) || Francis (5–15) || Perez (32) || 34,015 || 58–83 |- bgcolor="bbffbb" | 142 || September 5|| @ Oakland Athletics || W 11–6 || Holland (4–1) || Bailey (0–4) || || 14,577 || 59–83 |- bgcolor="bbffbb" | 143 || September 6|| @ Oakland Athletics || W 7–4 || Duffy (4–8) || Gonzalez (12–12) || Soria (26) || 12,064 || 60–83 |- bgcolor="ffbbbb" | 144 || September 7|| @ Oakland Athletics || L 0–7 || Moscoso (8–8) || Chen (10–7) || || 13,132 || 60–84 |- bgcolor="ffbbbb" | 145 || September 8|| @ Seattle Mariners || L 1–4 || Vargas (8–13) || Hochevar (10–10) || League (34) || 14,377 || 60–85 |- bgcolor="ffbbbb" | 146 || September 9|| @ Seattle Mariners || L 3–7 || Beavan (4–5) || Francis (5–16) || || 14,805 || 60–86 |- bgcolor="bbffbb" | 147 || September 10|| @ Seattle Mariners || W 4–2 || Paulino (3–10) || Pineda (9–10) || Soria (27) || 17,884 || 61–86 |- bgcolor="bbffbb" | 148 || September 11|| @ Seattle Mariners || W 2–1 || Teaford (1–0) || Vasquez (1–3) || Soria (28) || 20,951 || 62–86 |- bgcolor="bbffbb" | 149 || September 13|| Minnesota Twins || W 4–0 || Chen (11–7) || Pavano (8–12) || || 25,253 || 63–86 |- bgcolor="bbffbb" | 150 || September 14|| Minnesota Twins || W 7–3 || Hochevar (10–10) || Hendriks (0–2) || Holland (3) || 19,076 || 64–86 |- bgcolor="bbffbb" | 151 || September 15|| Chicago White Sox || W 7–2 || Francis (6–16) || Buehrle (11–9) || || 17,737 || 65–86 |- bgcolor="bbffbb" | 152 || September 16|| Chicago White Sox || W 7–6 || Holland (5–1) || Thornton (1–5) || || 24,918 || 66–86 |- bgcolor="bbffbb" | 153 || September 17|| Chicago White Sox || W 10–3 || Teaford (2–0) || Stewart (2–5) || Adcock (1) || 31,264 || 67–86 |- bgcolor="ffbbbb" | 154 || September 18|| Chicago White Sox || L 5–10 || Danks (7–12) || Chen (11–8) || || 29,480 || 67–87 |- bgcolor="bbffbb" | 155 || September 20|| Detroit Tigers || W 10–2 || Mendoza (1–0) || Penny (10–11) || || 26,953 || 68–87 |- bgcolor="ffbbbb" | 156 || September 21|| Detroit Tigers || L 3–6 || Fister (10–13) || Herrera (0–1) || Valverde (47) || 28,776 || 68–88 |- bgcolor="bbffbb" | 157 || September 23|| @ Chicago White Sox || W 11–1 || Chen (12–8) || Stewart