McClellan (5–1) || || 41,307 || 22–17 || |- align="center" bgcolor="bbffbb" | 40 || May 15 || Cardinals || FSO || W 9–7 || Wood (3–3) || Carpenter (1–3) || Cordero (7) || 24,672 || 23–17 || |- align="center" bgcolor="bbffbb" | 41 || May 16 || Cubs || FSO || W 7–4 || Bailey (3–0) || Zambrano (4–2) || Cordero (8) || 16,981 || 24–17 || |- align="center" bgcolor="bbffbb" | 42 || May 17 || Cubs || FSO || W 7–5 || Bray (1–0) || Wood (1–3) || Masset (1) || 18,861 || 25–17 || |- align="center" bgcolor="ffbbbb" | 43 || May 18 || Pirates || FSO || L 0–5 || Morton (5–1) || Arroyo (3–4) || || 16,543 || 25–18 || |- align="center" bgcolor="ffbbbb" | 44 || May 19 || Pirates || MLBN || L 3–5 || McDonald (3–3) || Cueto (2–1) || Hanrahan (12) || 26,018 || 25–19 || |- align="center" bgcolor="ffbbbb" | 45 || May 20 || @ Indians || FSO || L 4–5 || Pestano (1–0) || Bray (1–1) || Perez (11) || 31,622 || 25–20 || |- align="center" bgcolor="ffbbbb" | 46 || May 21 || @ Indians || FSO || L 1–2 || Tomlin (6–1) || Bailey (3–1) || Perez (12) || 40,631 || 25–21 || |- align="center" bgcolor="ffbbbb" | 47 || May 22 || @ Indians || FSO || L 4–12 || Carrasco (3–2) || Vólquez (3–2) || || 26,833 || 25–22 || |- align="center" bgcolor="ffbbbb" | 48 || May 23 || @ Phillies || FSO || L 3–10 || Hamels (6–2) || Arroyo (3–5) || || 45,841 || 25–23 || |- align="center" bgcolor="bbffbb" | 49 || May 24 || @ Phillies || FSO || W 6–3 || Ondrusek (3–2) || Madson (2–1) || Cordero (9) || 45,740 || 26–23 || |- align="center" bgcolor="ffbbbb" | 50 || May 25 || @ Phillies || FSO || L 4–5 (19) || Valdez (1–0) || Fisher (0–1) || || 45,706 || 26–24 || |- align="center" bgcolor="ffbbbb" | 51 || May 26 || @ Phillies || FSO || L 4–10 || Lee (4–4) || Thompson (0–1) || || 45,650 || 26–25 || |- align="center" bgcolor="bbffbb" | 52 || May 27 || @ Braves || FSO || W 5–1 || Leake (4–2) || Hanson (5–4) || || 30,701 || 27–25 || |- align="center" bgcolor="ffbbbb" | 53 || May 28 || @ Braves || Fox || L 6–7 (12) ||