|| Sale (5) || 28,621 || 56–74 || |- style="text-align:center; background:#fbb;" | 131 || August 27 || White Sox || 0–3 || Danks (6–9) || Pineda (9–8) || || 30,522 || 56–75 || |- style="text-align:center; background:#fbb;" | 132 || August 28 || White Sox || 3–9 || Floyd (12–10) || Vargas (7–12) || || 25,630 || 56–76 || |- style="text-align:center; background:#bfb;" | 133 || August 29 || Angels || 5–3 || Wilhelmsen (2–0) || Takahashi (3–3) || League (32) || 16,990 || 57–76 || |- style="text-align:center; background:#fbb;" | 134 || August 30 || Angels || 6–13 || Williams (2–0) || Vasquez (1–1) || || 15,536 || 57–77 || |- style="text-align:center; background:#bfb;" | 135 || August 31 || Angels || 2–1 || Hernández (13–11) || Haren (13–8) || || 18,520 || 58–77 || |- |- style="text-align:center; background:#fbb;" | 136 || September 1 || Angels || 3–4 || Santana (11–9) || Furbush (3–7) || Walden (27) || 19,453 || 58–78 || |- style="text-align:center; background:#fbb;" | 137 || September 2 || @ Athletics || 2–9 || Moscoso (7–8) || Vargas (7–13) || || 14,972 || 58–79 || |- style="text-align:center; background:#fbb;" | 138 || September 3 || @ Athletics || 0–3 || McCarthy (7–8) || Pineda (9–9) || || 19,732 || 58–80 || |- style="text-align:center; background:#fbb;" | 139 || September 4 || @ Athletics || 5–8 || Cahill (10–13) || Beavan (3–5) || Bailey (19) || 19,384 || 58–81 || |- style="text-align:center; background:#fbb;" | 140 || September 5 || @ Angels || 4–7 || Haren (14–8) || Vasquez (1–2) || || 35,497 || 58–82 || |- style="text-align:center; background:#bfb;" | 141 || September 6 || @ Angels || 2–1 || Hernández (14–11) || Santana (11–10) || League (33) || 36,533 || 59–82 || |- style="text-align:center; background:#fbb;" | 142 || September 7 || @ Angels || 1–3 || Williams (3–0) || Furbush (3–8) || Walden (29) || 37,459 || 59–83 || |- style="text-align:center; background:#bfb;" | 143 || September 8 || Royals || 4–1 || Vargas (8–13) || Hochevar (10–11) || League (34) || 14,377 || 60–83 || |- style="text-align:center; background:#bfb;" | 144 || September 9 || Royals || 7–3 || Beavan (4–5) || Francis (5–16) || || 14,805 || 61–83 || |- style="text-align:center; background:#fbb;" | 145 || September 10 || Royals || 2–4 || Paulino (3–10) || Pineda (9–10) || Soria (27) || 17,884 || 61–84 || |- style="text-align:center; background:#fbb;" | 146 || September 11 ||