43,363 || 13–15 || 4½ |- style="text-align:center; background:#fbb;" | 29 || May 3 || @ Rays || 3–2 || Farnsworth (2–0) || Rauch (1–2) || || 10,248 || 13–16 || 5 |- style="text-align:center; background:#cfc;" | 30 || May 4 || @ Rays || 3–2 || Morrow (1–1) || Niemann (1–4) || Francisco (1) || 10,099 || 14–16 || 4 |- style="text-align:center; background:#fbb;" | 31 || May 5 || @ Rays || 3–1 || Price (4–3) || Drabek (2–2) || Farnsworth (6) || 12,682 || 14–17 || 4 |- style="text-align:center; background:#cfc;" | 32 || May 6 || Tigers || 7–4 || Litsch (3–2) || Coke (1–5) || Francisco (2) || 19,711 || 15–17 || 4 |- style="text-align:center; background:#fbb;" | 33 || May 7 || Tigers || 9–0 || Verlander (3–3) || Romero (2–4) || || 23,453 || 15–18 || 4 |- style="text-align:center; background:#fbb;" | 34 || May 8 || Tigers || 5–2 || Penny (3–3) || Reyes (0–3) || Valverde (7) || 17,392 || 15–19 || 5 |- style="text-align:center; background:#fbb;" | 35 || May 9 || Tigers || 10–5 || Scherzer (6–0) || Morrow (1–2) || || 11,785 || 15–20 ||5½ |- style="text-align:center; background:#cfc;" | 36 || May 10 || Red Sox || 7–6 (10) || Villanueva (1–0) || Albers (0–1) || || 17,820 || 16–20 ||5½ |- style="text-align:center; background:#cfc;" | 37 || May 11 || Red Sox || 9–3 || Litsch (4–2) || Lackey (2–5) || || 19,163 || 17–20 ||4½ |- style="text-align:center; background:#cfc;" | 38 || May 13 || @ Twins || 2–0 || Romero (3–4) || Burnett (0–2) || Francisco (3) || 38,809 || 18–20 ||5 |- style="text-align:center; background:#cfc;" | 39 || May 14 || @ Twins || 9–3 (11) || Rauch (2–2) || Perkins (0–1) || || 39,934 || 19–20 ||4 |- style="text-align:center; background:#cfc;" | 40 || May 15 || @ Twins || 11–3 || Morrow (2–2) || Duensing (2–3) || || 39,301 || 20–20 ||3 |- style="text-align:center; background:#cfc;" | 41 || May 16 || @ Tigers || 4–2 || Drabek (3–2) || Benoit (1–3) || Francisco (4) || 20,444 || 21–20 ||3 |- style="text-align:center; background:#bbb;" |–|| May 17 || @ Tigers || colspan=6|Postponed (rain) Rescheduled for June 27|| 2½ |- style="text-align:center; background:#fbb;" | 42 || May 18 || Rays || 6–5 || Hellickson (5–2) || Litsch (4–3) || Farnsworth (9) || 14,415 || 21–21 || 3½ |- style="text-align:center; background:#cfc;" | 43 || May 19 || Rays