|| Cardinals || 4–6 || McClellan (11–6) || Hanrahan (0–4) || Motte (6) || 16,544 || 67–81 |- style="background:#fbb;" | 149 || September 14 || Cardinals || 2–3 || Jackson (5–2) || Morton (9–10) || Motte (7) || 12,520 || 67–82 |- style="background:#cfc;" | 150 || September 15 || @ Dodgers || 6–2 || Ohlendorf (1–2) || Eveland (2–1) || Hanrahan (38) || 25,381 || 68–82 |- style="background:#fbb;" | 151 || September 16 || @ Dodgers || 2–7 || Kuroda (12–16) || Locke (0–2) || — || 41,148 || 68–83 |- style="background:#fbb;" | 152 || September 17 || @ Dodgers || 1–6 || Lilly (10–14) || McDonald (9–9) || — || 32,514 || 68–84 |- style="background:#fbb;" | 153 || September 18 || @ Dodgers || 1–15 || Billingsley (11–10) || Lincoln (1–3) || — || 37,802 || 68–85 |- style="background:#fbb;" | 154 || September 19 || @ D-backs || 0–1 || Kennedy (20–4) || Karstens (9–9) || Putz (42) || 24,458 || 68–86 |- style="background:#cfc;" | 155 || September 20 || @ D-backs || 5–3 || Morton (10–10) || Hudson (16–11) || Hanrahan (39) || 30,114 || 69–86 |- style="background:#fbb;" | 156 || September 21 || @ D-backs || 5–8 || Miley (4–2) || Ohlendorf (1–3) || Putz (43) || 25,296 || 69–87 |- style="background:#cfc;" | 157 || September 23 || Reds || 4–3 || Hanrahan (1–4) || Bray (5–3) || — || 23,632 || 70–87 |- style="background:#cfc;" | 158 || September 24 || Reds || 4–3 || Lincoln (2–3) || Wood (6–6) || Grilli (1) || 37,388 || 71–87 |- style="background:#fbb;" | 159 || September 25 || Reds || 4–5 || Willis (1–6) || Moskos (1–1) || Cordero (35) || 28,758 || 71–88 |- style="background:#cfc;" | 160 || September 26 || @ Brewers || 9–8 || McCutchen (5–3) || Saito (4–2) || Hanrahan (40) || 41,222 || 72–88 |- style="background:#fbb;" | 161 || September 27 || @ Brewers || 4–6 || Hawkins (3–1) || Hughes (0–1) || Axford (46) || 41,864 || 72–89 |- style="background:#fbb;" | 162 || September 28 || @ Brewers || 3–7 || Greinke (16–6) || Locke (0–3) || — || 41,976 || 72–90 |- |- | Legend: = Win = Loss = PostponementBold = Pirates team member Divisional standings Record vs. opponents Detailed records Roster Opening Day lineup Notable achievements Awards 2011 Major League Baseball All-Star Game Joel Hanrahan, P, reserve Andrew McCutchen, OF, reserve