|- style="text-align:center; background:#bfb;" | 149 || September 17 || @ Twins || 10–4 || Gómez (4–2) || Swarzak (3–7) || || 38,805 || 74–75 |- style="text-align:center; background:#bfb;" | 150 || September 18 || @ Twins || 6–5 || Masterson (12–10) || Pavano (8–13) || C. Perez (34) || 37,012 || 75–75 |- style="text-align:center; background:#fbb;" | 151 || September 19 || Mariners || 12–6 (7) || Furbush (4–9) || Huff (2–6) || || 15,354 || 75–76 |- style="text-align:center; background:#bfb;" | 152 || September 20 || White Sox || 4–3 || Carmona (7–15) || Floyd (12–12) || C. Perez (35) || 28,603 || 76–76 |- style="text-align:center; background:#fbb;" | 153 || September 20 || White Sox || 5–4 || Thornton (2–5) || Putnam (0–1) || Sale (7) || 19,582 || 76–77 |- style="text-align:center; background:#fbb;" | 154 || September 21 || White Sox || 8–4 || Buehrle (12–9) || Jiménez (4–3) || || 12,400 || 76–78 |- style="text-align:center; background:#bfb;" | 155 || September 22 || White Sox || 11–2 || Gómez (5–2) || Humber (9–9) || || 21,487 || 77–78 |- style="text-align:center; background:#bfb;" | 156 || September 23 || Twins || 6–5 || C. Perez (4–7) || Capps (4–7) || || 36,807 || 78–78 |- style="text-align:center; background:#bfb;" | 157 || September 24 || Twins || 8–2 || Putnam (1–1) || Liriano (9–10) || || 26,197 || 79–78 |- style="text-align:center; background:#bfb;" | 158 || September 24 || Twins || 7–6 || Hagadone (1–0) || Mijares (0–2) || C. Perez (36) || 30,748 || 80–78 |- style="text-align:center; background:#fbb;" | 159 || September 25 || Twins || 6–4 (10) || Waldrop (1–0) || Sipp (6–3) || Nathan (14) || 22,539 || 80–79 |- style="text-align:center; background:#fbb;" | 160 || September 26 || @ Tigers || 14–0 || Fister (11–13) || Jiménez (4–4) || || 29,886 || 80–80 |- style="text-align:center; background:#fbb;" | 161 || September 27 || @ Tigers || 9–6 || Scherzer (15–9) || Gómez (5–3) || Valverde (48) || 31,132 || 80–81 |- style="text-align:center; background:#fbb;" | 162 || September 28 || @ Tigers || 5–4 || Perry (2–0) || Pestano (1–2) || Valverde (49) || 31,645 || 80–82 |- Player stats Batting Note: G = Games played; AB = At bats; R = Runs scored; H = Hits; 2B = Doubles; 3B = Triples; HR = Home runs; RBI = Runs batted in; AVG = Batting average; SB = Stolen bases Pitching Note: W = Wins; L