44–68 |- style="text-align:center; background:#fbb;" | 113 || August 9 || White Sox || 3–4 || Floyd (10–10) || Reyes (5–9) || Santos (24) || 14,177 || 44–69 |- style="text-align:center; background:#cfc;" | 114 || August 10 || White Sox || 6–4 (10) || Gonzalez (2–2) || Frasor (2–2) || || 18,747 || 45–69 |- style="text-align:center; background:#fbb;" | 115 || August 11 || White Sox || 3–6 || Buehrle (10–5) || Tillman (3–5) || Santos (25) || 21,040 || 45–70 |- style="text-align:center; background:#fbb;" | 116 || August 12 || Tigers || 4–5 || Penny (8–9) || Patton (0–1) || Valverde (34) || 21,465 || 45–71 |- style="text-align:center; background:#fbb;" | 117 || August 13 || Tigers || 5–6 || Scherzer (12–7) || Guthrie (5–16) || Valverde (35) || 24,144 || 45–72 |- style="text-align:center; background:#bfb;" | 118 || August 14 || Tigers || 8–5 || Reyes (6–9) || Fister (4–13) || Johnson (2) || 18,348 || 46–72 |- style="text-align:center; background:#bfb;" | 119 || August 15 || @ Athletics || 6–2 || Hunter (2–2) || Gonzalez (9–11) || || 10,122 || 47–72 |- style="text-align:center; background:#fbb;" | 120 || August 16 || @ Athletics || 4–8 || Moscoso (6–6) || Matusz (1–5) || ||12,325 || 47–73 |- style="text-align:center; background:#fbb;" | 121 || August 17 || @ Athletics || 5–6 || McCarthy (6–6) || Simón (3–6) || Bailey (15) || 20,448 || 47–74 |- style="text-align:center; background:#fbb;" | 122 || August 19 || @ Angels || 3–8 || Haren (13–6) || Reyes (6–10) || || 38,156 || 47–75 |- style="text-align:center; background:#fbb;" | 123 || August 20 || @ Angels || 8–9 (12) || Rodney (3–5) || Gregg (0–2) || || 43,201 || 47–76 |- style="text-align:center; background:#fbb;" | 124 || August 21 || @ Angels || 1–7 || Williams (1–0) || Matusz (1–6) || || 37,148 || 47–77 |- style="text-align:center; background:#bfb;" | 125 || August 22 || @ Twins || 4–1 || Britton (7–9) || Pavano (6–10) || Gregg (18) || 38,986 || 48–77 |- style="text-align:center; background:#bfb;" | 126 || August 23 || @ Twins || 8–1 || Simón (4–6) || Duensing (8–13) || || 38,786 || 49–77 |- style="text-align:center; background:#bfb;" | 127 || August 24 || @ Twins || 6–1 || Guthrie (6–16) || Slowey (0–2) || || 37,778 || 50–77 |- style="text-align:center; background:#bfb;" | 128 || August 25 || @ Twins || 6–1 || Reyes (7–10) || Swarzak (3–4) || || 38,406 || 51–77 |- style="text-align:center; background:#bfb;"