145 || September 11 || @ Blue Jays || 5–6 || Carreño (1–0) || Hunter (3–4) || Francisco (14) || 14,235 || 58–87 |- style="text-align:center; background:#fbb;" | 146 || September 12 || Rays || 2–5 || Niemann (10–7) || Britton (9–10) || Peralta (3) || 11,924 || 58–88 |- style="text-align:center; background:#bfb;" | 147 || September 13 || Rays || 4–2 || Patton (1–1) || Howell (2–3) || Johnson (5) || 13,262 || 59–88 |- style="text-align:center; background:#bfb;" | 148 || September 14 || Rays || 6–2 || Guthrie (8–17) || Davis (10–9) || Johnson (6) || 14,669 || 60–88 |- style="text-align:center; background:#bfb;" | 149 || September 16 || Angels || 8–3 || Hunter (4–4) || Haren (15–9) || || 24,022 || 61–88 |- style="text-align:center; background:#bfb;" | 150 || September 17 || Angels || 6–2 || Britton (10–10) || Santana (11–12) || || 31,099 || 62–88 |- style="text-align:center; background:#fbb;" | 151 || September 18 || Angels || 2–11 || Weaver (18–7) || Simón (4–9) || || 27471 || 62–89 |- style="text-align:center; background:#bfb;" | 152 || September 19 || @ Red Sox || 6–5 || Guthrie (9–17) || Weiland (0–3) || Johnson (7) || 37,885 || 63–89 |- style="text-align:center; background:#fbb;" | 153 || September 19 || @ Red Sox || 9–18 || Atchison (1–0) || Matusz (1–8) || || 37,261 || 63–90 |- style="text-align:center; background:#bfb;" | 154 || September 20 || @ Red Sox || 7–5 || Eyre (2–1) || Bard (2–9) || Johnson (8) || 37,414 || 64–90 |- style="text-align:center; background:#bfb;" | 155 || September 21 || @ Red Sox || 6–4 || Rapada (2–0) || Beckett (13–6) || Johnson (9) || 38,004 || 65–90 |- style="text-align:center; background:#bfb;" | 156 || September 22 || @ Tigers || 6–5 || Britton (11–10) || Pauley (5–6) || Gregg (21) || 27,847 || 66–90 |- style="text-align:center; background:#fbb;" | 157 || September 23 || @ Tigers || 3–4 (11) || Perry (1–0) || Eyre (2–2) || || 38,623 || 66–91 |- style="text-align:center; background:#bfb;" | 158 || September 24 || @ Tigers || 6–5 || Strop (2–1) || Schlereth (2–2) || Gregg (22) || 44,846|| 67–91 |- style="text-align:center; background:#fbb;" | 159 || September 25 || @ Tigers || 6–10 || Penny (11–11) || Matusz (1–9) || || 41,051 || 67–92 |- style="text-align:center; background:#bfb;" | 160 || September 26|| Red Sox || 6–3 || Patton (2–1) || Beckett (13–7) || || 21,786 || 68–92 |- style="text-align:center; background:#fbb;" |