3 || April 3 || @ Rays || 5–1 || Britton (1–0) || Davis (0–1) || || 17,408 || 3–0 |- style="text-align:center; background:#cfc;" | 4 || April 4 || Tigers || 5–1 || Arrieta (1–0) || Porcello (0–1) || || 46,593 || 4–0 |- style="text-align:center; background:#fbb;" | 5 || April 6 || Tigers || 3–7 || Verlander (1–0) || Bergesen (0–1) || || 12,451 || 4–1 |- style="text-align:center; background:#cfc;" | 6 || April 7 || Tigers || 9–5 || Johnson (1–0) || Thomas (0–1) || || 11,648 || 5–1 |- style="text-align:center; background:#bbb;" | – || April 8 || Rangers || colspan=6| Postponed (rain); Makeup: April 9 as part of a doubleheader |- style="text-align:center; background:#cfc;" | 7 || April 9 || Rangers || 5–0 || Britton (2–0) || Lewis (0–1) || || — || 6–1 |- style="text-align:center; background:#fbb;" | 8 || April 9 || Rangers || 1–13 || Harrison (2–0) || Arrieta (1–1) || || 36,243 || 6–2 |- style="text-align:center; background:#fbb;" | 9 || April 10 || Rangers || 0–3 || Holland (2–0) || Guthrie (1–1) || Feliz (3) || 21,452 || 6–3 |- style="text-align:center; background:#bbb;" | – || April 12 || @ Yankees || colspan=6| Postponed (rain); Makeup: July 30 as part of a doubleheader |- style="text-align:center; background:#fbb;" | 10 || April 13 || @ Yankees || 4–7 || Burnett (3–0) || Tillman (0–1) || Rivera (5) || 42,171 || 6–4 |- style="text-align:center; background:#fbb;" | 11 || April 14 || @ Yankees || 5–6 (10) || Rivera (1–0) || Gonzalez (0–1) || || 40,517 || 6–5 |- style="text-align:center; background:#fbb;" | 12 || April 15 || @ Indians || 2–8 || Masterson (3–0) || Britton (2–1) || || 16,346 || 6–6 |- style="text-align:center; background:#fbb;" | 13 || April 16 || @ Indians || 3–8 || Tomlin (3–0) || Guthrie (1–2) || || 10,714 || 6–7 |- style="text-align:center; background:#fbb;" | 14 || April 17 || @ Indians || 2–4 || Carmona (1–2) || Bergesen (0–2) || Perez (5) || 13,017 || 6–8 |- style="text-align:center; background:#fbb;" | 15 || April 18 || Twins || 3–5 || Liriano (1–3) || Tillman (0–2) || Capps (2) || 13,138 || 6–9 |- style="text-align:center; background:#cfc;" | 16 || April 19 || Twins || 11–0 || Arrieta (2–1) || Pavano (1–2) || || 12,045 || 7–9 |- style="text-align:center; background:#cfc;" | 17 || April 20 || Twins || 5–4 || Britton (3–1) || Blackburn (1–3) || Gregg (2) ||