22–24 |- bgcolor="ffbbbb" | 47 || May 24|| @ Baltimore Orioles || L 3–5 || Simón (1–0) || Soria (3–1) || || 14,077 || 22–25 |- bgcolor="ffbbbb" | 48 || May 25|| @ Baltimore Orioles || L 2–9 || Arrieta (6–2) || Hochevar (3–5) || || 15,740 || 22–26 |- bgcolor="ffbbbb" | 49 || May 26|| @ Baltimore Orioles || L 5–6(12) || Accardo (3–1) || Coleman (0–2) || || 22,720 || 22–27 |- bgcolor="bbffbb" | 50 || May 27|| @ Texas Rangers || W 12–7 (14) || Wood (2–0) || Bush (0–1) || || 39,390 || 23–27 |- bgcolor="ffbbbb" | 51 || May 28|| @ Texas Rangers || L 1–10 || Harrison (5–4) || O'Sullivan (2–4) || Tateyama (1) || 40,240 || 23–28 |- bgcolor="ffbbbb" | 52 || May 29|| @ Texas Rangers || L 6–7 || Rhodes (3–2) || Soria (3–2) || || 45,011 || 23–29 |- bgcolor="ffbbbb" | 53 || May 30|| Los Angeles Angels || L 8–10 || Jepsen (1–2) || Soria (3–3) || Rodney (3) || 24,406 || 23–30 |- bgcolor="bbffbb" | 54 || May 31|| Los Angeles Angels || W 7–3 || Francis (2–5) || Piñeiro (2–2) || || 14,174 || 24–30 |- |- bgcolor="bbffbb" | 55 || June 1|| Los Angeles Angels || W 2–0 || Collins (3–2) || Downs (3–2) || || 12,022 || 25–30 |- bgcolor="ffbbbb" | 56 || June 2|| Minnesota Twins || L 2–8 || Swarzak (1–2) || O'Sullivan (2–5) || || 14,584 || 25–31 |- bgcolor="ffbbbb" | 57 || June 3|| Minnesota Twins || L 2–5 || Pavano (3–5) || Duffy (0–1) || || 32,443 || 25–32 |- bgcolor="ffbbbb" | 58 || June 4|| Minnesota Twins || L 2–7 || Blackburn (5–4) || Hochevar (3–6) || || 27,861 || 25–33 |- bgcolor="ffbbbb" | 59 || June 5|| Minnesota Twins || L 0–6 || Duensing (3–5) || Francis (2–6) || || 21,704 || 25–34 |- bgcolor="bbffbb" | 60 || June 6|| Toronto Blue Jays || W 3–2 (11) || Soria (4–3) || Francisco (1–3) || || 12,194 || 26–34 |- bgcolor="ffbbbb" | 61 || June 7|| Toronto Blue Jays || L 5–8 || Drabek (4–4) || Mazzaro (0–1) || Rauch (7) || 16,539 || 26–35 |- bgcolor="ffbbbb" | 62 || June 8|| Toronto Blue Jays || L 8–9 || Villanueva (4–0) || Duffy (0–1) || Janssen (1) || 12,152 || 26–36 |- bgcolor="bbffbb" | 63 || June 9|| Toronto