(1) || 49,374 || 0–1 |- align="center" bgcolor="bbffbb" | 2 || April 2 || Diamondbacks || 3–1 || de la Rosa (1–0) || Hudson (0–1) || Street (1) || 40,216 || 1–1 |- align="center" bgcolor="bbbbbb" | – || April 3 || Diamondbacks || colspan=6 | Postponed (rain/snow) Rescheduled for May 24 |- align="center" bgcolor="bbffbb" | 3 || April 5 || Dodgers || 3–0 || Chacín (1–0) || Kershaw (1–1) || Street (2) || 24,693 || 2–1 |- align="center" bgcolor="bbffbb" | 4 || April 6 || Dodgers || 7–5 || Hammel (1–0) || Billingsley (1–1) || Street (3) || 22,595 || 3–1 |- align="center" bgcolor="bbffbb" | 5 || April 7 || @ Pirates || 7–1 || Rogers (1–0) || Maholm (0–1) || || 39,219 || 4–1 |- align="center" bgcolor="ffbbbb" | 6 || April 8 || @ Pirates || 4–3 (14) || Olson (1–1) || Morales (0–1) || || 29,192 || 4–2 |- align="center" bgcolor="bbffbb" | 7 || April 9 || @ Pirates || 6–4 || Belisle (1–0) || Veras (0–1) || Lindstrom (1) || 25,398 || 5–2 |- align="center" bgcolor="bbffbb" | 8 || April 10 || @ Pirates || 6–5 || Chacín (2–0) || Crotta (0–1) || Street (4) || 18,043 || 6–2 |- align="center" bgcolor="bbffbb" | 9 || April 11 || @ Mets || 7–6 || Belisle (2–0) || Parnell (0–1) || Street (5) || 24,865 || 7–2 |- align="center" bgcolor="bbbbbb" | – || April 12 || @ Mets || colspan=6 | Postponed (rain) Rescheduled for April 14 |- align="center" bgcolor="bbffbb" | 10 || April 13 || @ Mets || 5–4 || Rogers (2–0) || Niese (0–2) || Street (6) || 25,878 || 8–2 |- align="center" bgcolor="bbffbb" | 11 || April 14 || @ Mets || 6–5 || G. Reynolds (1–0) || Dickey (1–2) || Lindstrom (2) || || 9–2 |- align="center" bgcolor="bbffbb" | 12 || April 14 || @ Mets || 9–4 || de la Rosa (2–0) || Capuano (1–1) || || 25,758 || 10–2 |- align="center" bgcolor="bbffbb" | 13 || April 15 || Cubs || 5–0 || Chacín (3–0) || Garza (0–2) || || 30,285 || 11–2 |- align="center" bgcolor="ffbbbb" | 14 || April 16 || Cubs || 8–3 || Coleman (1–0) || Hammel (1–1) || || 40,264 || 11–3 |- align="center" bgcolor="bbffbb" | 15 || April 17 || Cubs || 9–5 || Betancourt (1–0) || Mateo (0–1) || || 42,212 || 12–3 |- align="center" bgcolor="ffbbbb" | 16||