League (0–4) || || 33,774 || 16–23 || |- style="text-align:center; background:#bbb;" | – || May 14 || @ Indians || colspan=7|Postponed (rain); Makeup: August 23 (Game 1) |- style="text-align:center; background:#bbb;" | – || May 15 || @ Indians || colspan=7|Postponed (rain); Makeup: September 19 |- style="text-align:center; background:#bfb;" | 40 || May 16 || Twins || 5–2 || Pineda (5–2) || Baker (2–3) || || 14,859 || 17–23 || |- style="text-align:center; background:#fbb;" | 41 || May 17 || Twins || 1–2 || Liriano (3–5) || Hernández (4–4) || Capps (6) || 16,015 || 17–24 || |- style="text-align:center; background:#bfb;" | 42 || May 18 || Angels || 3–0 || Vargas (3–2) || Weaver (6–4) || League (10) || 16,992 || 18–24 || |- style="text-align:center; background:#bfb;" | 43 || May 19 || Angels || 2–1 || Pauley (2–0) || Downs (1–1) || || 18,374 || 19–24 || |- style="text-align:center; background:#bfb;" | 44 || May 20 || @ Padres || 4–1 || Bédard (2–4) || Latos (1–6) || || 26,501 || 20–24 || |- style="text-align:center; background:#bfb;" | 45 || May 21 || @ Padres || 4–0 || Pineda (6–2) || Richard (2–5) || || 34,648 || 21–24 || |- style="text-align:center; background:#bfb;" | 46 || May 22 || @ Padres || 6–1 || Hernández (5–4) || Stauffer (0–3) || || 34,705 || 22–24 || |- style="text-align:center; background:#bfb;" | 47 || May 23 || @ Twins || 8–7 (10) || Wright (1–1) || Swarzak (0–2) || League (11) || 37,498 || 23–24 || |- style="text-align:center; background:#fbb;" | 48 || May 24 || @ Twins || 2–4 || Blackburn (4–4) || Fister (2–5) || || 37,691 || 23–25 || |- style="text-align:center; background:#bfb;" | 49 || May 25 || @ Twins || 3–0 || Bédard (3–4) || Duensing (2–5) || League (12) || 38,860 || 24–25 || |- style="text-align:center; background:#bfb;" | 50 || May 27 || Yankees || 4–3 || Pauley (3–0) || Ayala (1–1) || League (13) || 33,715 || 25–25 || |- style="text-align:center; background:#bfb;" | 51 || May 28 || Yankees || 5–4 (12) || Pauley (4–0) || Rivera (1–1) || – || 37,354 || 26–25 || |- style="text-align:center; background:#fbb;" | 52 || May 29 || Yankees || 1–7 || Sabathia (6–3) || Vargas (3–3) || || 37,290 || 26–26 || |- style="text-align:center; background:#bfb;" | 53 || May 30 || Orioles || 4–3 || Fister (3–5) || Arrieta (6–3) || League (14) || 22,819 || 27–26