a compensation pick from the Los Angeles Angels of Anaheim for signing type-A free agent Scott Downs Roster Top prospects * According to Baseball America Top 100 Prospects * According to Scouting Book Top Minor League Prospects * Top 10 Blue Jays prospects via Baseball America Game log Regular season |- style="text-align:center; background:#cfc;" | 1 || April 1 || Twins || 13–3 || Romero (1–0) || Pavano (0–1) || || 47,984 || 1–0 || – |- style="text-align:center; background:#cfc;" | 2 || April 2 || Twins || 6–1 || Drabek (1–0) || Liriano (0–1) || || 27,194 || 2–0 || – |- style="text-align:center; background:#fbb;" | 3 || April 3 || Twins || 4–3 || Blackburn (1–0) || Cecil (0–1) || Nathan (1) || 35,505 || 2–1 || 1 |- style="text-align:center; background:#cfc;" | 4 || April 5 || Athletics || 7–6 (10) || Frasor (1–0) || Balfour (0–1) || || 11,077 || 3–1 || 1 |- style="text-align:center; background:#cfc;" | 5 || April 6 || Athletics || 5–3 || Litsch (1–0) || Braden (0–1) || Rauch (1) || 11,684 || 4–1 || – |- style="text-align:center; background:#fbb;" | 6 || April 7 || Athletics || 2–1 || Cahill (1–0) || Frasor (1–1) || Fuentes (1) || 19,528 || 4–2 || 1 |- style="text-align:center; background:#cfc;" | 7 || April 8 || @ Angels || 3–2 || Dotel (1–0) || Santana (0–1) || Rauch (2) || 43,853 || 5–2 || ½ |- style="text-align:center; background:#fbb;" | 8 || April 9 || @ Angels || 6–5 (14) || Haren (2–0) || Rauch (0–1) || || 43,513 || 5–3 || 1 |- style="text-align:center; background:#fbb;" | 9 || April 10 || @ Angels || 3–1 || Weaver (3–0) || Reyes (0–1) || Rodney (2) || 43,525 || 5–4 || 1 |- style="text-align:center; background:#fbb;" | 10 || April 11 || @ Mariners || 8–7 || Lueke (1–0) || Camp (0–1) || || 13,056 || 5–5 || 1½ |- style="text-align:center; background:#fbb;" | 11 || April 12 || @ Mariners || 3–2 || Pineda (1–1) || Romero (1–1) || League (2) || 15,500 || 5–6 || 2 |- style="text-align:center; background:#cfc;" | 12 || April 13 || @ Mariners || 8–3 || Rzepczynski (1–0) || Ray (1–1)|| || 12,407 || 6–6 || 1 |- style="text-align:center; background:#cfc;" | 13 || April 15 || @ Red Sox || 7–6 || Cecil (1–1) || Jenks (0–1) || Rauch (3) || 37,467 || 7–6 || ½ |- style="text-align:center;