background:#fbb;" | 33 || May 8 || Rays || 3–5 || Davis (4–2) || Bergesen (0–4) || Farnsworth (7) || 16,359 || 14–19 |- style="text-align:center; background:#cfc;" | 34 || May 10 || Mariners || 7–6 (13) || Accardo (2–0) || League (0–2) || || 11,485 || 15–19 |- style="text-align:center; background:#cfc;" | 35 || May 11 || Mariners || 4–2 || Tillman (2–3) || F. Hernández (4–3) || Gregg (7) || 11,561 || 16–19 |- style="text-align:center; background:#cfc;" | 36 || May 12 || Mariners || 2–1 (12) || Johnson (2–1) || League (0–3) || || 19,082 || 17–19 |- style="text-align:center; background:#fbb;" | 37 || May 13 || @ Rays || 0–3 || Hellickson (4–2) || Guthrie (1–6) || || 20,476 || 17–20 |- style="text-align:center; background:#cfc;" | 38 || May 14 || @ Rays || 6–0 || Bergesen (1–4) || Davis (4–3) || || 28,451 || 18–20 |- style="text-align:center; background:#cfc;" | 39 || May 15 || @ Rays || 9–3 || Arrieta (5–1) || Sonnanstine (0–1) || || 21,505 || 19–20 |- style="text-align:center; background:#fbb;" | 40 || May 16 || @ Red Sox || 7–8 || Aceves (1–0) || Gregg (0–1) || || 37,138 || 19–21 |- style="text-align:center; background:#bbb;" | – || May 17 || @ Red Sox || colspan=6| Postponed (rain); Makeup: September 19 as part of a doubleheader |- style="text-align:center; background:#fbb;" | 41 || May 18 || Yankees || 1–4 (15) || Noesí (1–0) || Accardo (2–1) || || 20,589 || 19–22 |- style="text-align:center; background:#fbb;" | 42 || May 19 || Yankees || 2–13 || Sabathia (4–3) || Bergesen (1–5) || || 24,939 || 19–23 |- style="text-align:center; background:#fbb;" | 43 || May 20 || Nationals || 5–17 || Rodriguez (1–0) || Arrieta (5–2) || || 24,442 || 19–24 |- style="text-align:center; background:#cfc;" | 44 || May 21 || Nationals || 8–3 || Guthrie (2–6) || Lannan (2–5) || || 33,107 || 20–24 |- style="text-align:center; background:#cfc;" | 45 || May 22 || Nationals || 2–1 || Johnson (3–1) || Zimmermann (2–5) || Gregg (8) || 33,626 || 21–24 |- style="text-align:center; background:#cfc;" | 46 || May 24 || Royals || 5–3 || Simón (1–0) || Soria (3–1) || || 14,077 || 22–24 |- style="text-align:center; background:#cfc;" | 47 || May 25 || Royals || 9–2 || Arrieta (6–2) || Hochevar (3–5) || || 15,740 || 23–24 |- style="text-align:center; background:#cfc;" | 48 || May 26 || Royals || 6–5 (12) || Accardo (3–1) || Coleman