May 8 || @ Cardinals || 3–1 || McClellan (5–0) || Narveson (1–3) || Salas (3) || 40,125 || 14–20 |- align="center" bgcolor="bbffbb" | 35 || May 9 || Padres || 4–3 || Greinke (1–1) || Latos (0–5) || Axford (6) || 27,058 || 15–20 |- align="center" bgcolor="bbffbb" | 36 || May 10 || Padres || 8–6 || Marcum (4–1) || Richard (1–4) || Axford (7) || 22,861 || 16–20 |- align="center" bgcolor="ffbbbb" | 37 || May 11 || Padres || 13–6 || Qualls (2–2) || Loe (2–4) || || 25,652 || 16–21 |- align="center" bgcolor="bbffbb" | 38 || May 13 || Pirates || 5–2 || Gallardo (4–2) || McDonald (2–3) || Axford (8) || 32,837 || 17–21 |- align="center" bgcolor="bbffbb" | 39 || May 14 || Pirates || 8–2 || Narveson (2–3) || Karstens (2–2) || || 42,422 || 18–21 |- align="center" bgcolor="bbffbb" | 40 || May 15 || Pirates || 9–6 || Greinke (2–1) || Correia (5–4) || || 37,059 || 19–21 |- align="center" bgcolor="bbffbb" | 41 || May 16 || @ Dodgers || 2–1 || Marcum (5–1) || Garland (1–3) || Axford (9) || 35,346 || 20–21 |- align="center" bgcolor="ffbbbb" | 42 || May 17 || @ Dodgers || 3–0 || Kuroda (5–3) || Wolf (3–4) || Guerrier (1) || 42,138 || 20–22 |- align="center" bgcolor="bbffbb" | 43 || May 18 || @ Padres || 5–2 || Gallardo (5–2) || Moseley (1–6) || Axford (10) || 16,901 || 21–22 |- align="center" bgcolor="ffbbbb" | 44 || May 19 || @ Padres || 1–0 || Bell (2–0) || Estrada (1–2) || || 16,286 || 21–23 |- align="center" bgcolor="bbffbb" | 45 || May 20 || Rockies || 7–6 (14) || McClendon (1–0) || Paulino (0–4) || || 33,361 || 22–23 |- align="center" bgcolor="bbffbb" | 46 || May 21 || Rockies || 3–2 || Marcum (6–1) || Mortensen (1–1) || Axford (11) || 42,240 || 23–23 |- align="center" bgcolor="bbffbb" | 47 || May 22 || Rockies || 3–1 || Wolf (4–4) || Jiménez (0–4) || Axford (12) || 42,605 || 24–23 |- align="center" bgcolor="bbffbb" | 48 || May 23 || Nationals || 11–3 || Gallardo (6–2) || Gorzelanny (2–4) || || 22,906 || 25–23 |- align="center" bgcolor="bbffbb" | 49 || May 24 || Nationals || 7–6 || McClendon (2–0) || Rodríguez (1–1) || Axford (13) || 24,722 || 26–23 |- align="center" bgcolor="bbffbb" | 50 || May 25 || Nationals || 6–4