| 129 || August 26 || Yankees || 12–5 || Hunter (3–2) || Burnett (9–11) || || 32,762 || 52–77 |- style="text-align:center; background:#bbb;" | || August 27 || Yankees || colspan=6| Postponed (Hurricane Irene); Makeup: September 8 |- style="text-align:center; background:#bfb;" | 130 || August 28 || Yankees || 2–0 || Britton (7–9) || Colón (8–9) || Gregg (19) || 28,751 || 53–77 |- style="text-align:center; background:#fbb;" | 131 || August 28 || Yankees || 3–8 || Nova (14–4) || Matusz (1–7) || || 37,528 || 53–78 |- style="text-align:center; background:#fbb;" | 132 || August 29 || Yankees || 2–3 || García (11–7) || Simón (4–7) || Rivera (34) || 18,223 || 53–79 |- style="text-align:center; background:#bfb;" | 133 || August 30 || Blue Jays || 6–5 (10) || Eyre (1–0) || Tallet (0–2) || || 10,756 || 54–79 |- style="text-align:center; background:#fbb;" | 134 || August 31 || Blue Jays || 0–13 || Álvarez (1–2) || Reyes (7–11) || || 14,211 || 54–80 |- |- style="text-align:center; background:#fbb;" | 135 || September 1 || Blue Jays || 6–8 || Camp (2–3) || Eyre (1–1) || Francisco (12) || 11,617 || 54–81 |- style="text-align:center; background:#bfb;" | 136 || September 2 || @ Rays || 3–2 || Britton (9–9) || Price (12–12) || Gregg (20) || 11,955 || 55–81 |- style="text-align:center; background:#fbb;" | 137 || September 3 || @ Rays || 3–6 || Davis (9–8) || Simón (4–8) || Farnsworth (23) || 14,233 || 55–82 |- style="text-align:center; background:#fbb;" | 138 || September 4 || @ Rays || 1–8 || Hellickson (12–10) || Guthrie (6–17) || || 15,790 || 55–83 |- style="text-align:center; background:#fbb;" | 139 || September 5 || @ Yankees || 10–11 ||Laffey (2–1)||Johnson (5–5)||Rivera (38)||45,069||55–84 |- style="text-align:center; background:#fbb;" | 140 || September 6 || @ Yankees || 3–5 ||Wade (4–0)||Hunter (3–3)||Rivera (39)||44,573||55–85 |- style="text-align:center; background:#bfb;" | 141 || September 7 || @ Yankees || 5–4 (11) || Strop (1–1)|| Noesí (2–1)|| Johnson (3)|| 40,104 || 56–85 |- style="text-align:center; background:#bfb;" | 142 || September 8 || Yankees || 5–4 (10) || Rapada (1–0) || Proctor (2–4) || || 33,841 || 57–85 |- style="text-align:center; background:#bfb;" | 143 || September 9 || @ Blue Jays || 2–0 || Guthrie (7–17) || Cecil (4–9) || Johnson (4) || 13,918 || 58–85 |- style="text-align:center; background:#fbb;" | 144 || September 10 || @ Blue Jays || 4–5 || Litsch (6–3) || Gregg (0–3) || || 17,742 || 58–86 |- style="text-align:center; background:#fbb;" |