Fister (0–2) || Perez (3) || 30,309 || 2–6 || |- style="text-align:center; background:#fbb;" | 9 || April 10 || Indians || 4–6 || Tomlin (2–0) || Bédard (0–2) || Perez (4) || 21,128 || 2–7 || |- style="text-align:center; background:#bfb;" | 10 || April 11 || Blue Jays || 8–7 || Lueke (1–0) || Camp (0–1) || || 13,056 || 3–7 || |- style="text-align:center; background:#bfb;" | 11 || April 12 || Blue Jays || 3–2 || Pineda (1–1) || Romero (1–1) || League (2) || 15,500 || 4–7 || |- style="text-align:center; background:#fbb;" | 12 || April 13 || Blue Jays || 3–8 || Rzepczynski (1–0) || Ray (1–1) || || 12,407 || 4–8 || |- style="text-align:center; background:#fbb;" | 13 || April 14 || @ Royals || 1–5 (8) || Chen (2–0) || Fister (0–3) || || 8,811 || 4–9 || |- style="text-align:center; background:#fbb;" | 14 || April 15 || @ Royals || 5–6 || Hochevar (2–1) || Bédard (0–3) || Soria (4) || 13,686 || 4–10 || |- style="text-align:center; background:#fbb;" | 15 || April 16 || @ Royals || 0–7 || O'Sullivan (1–1) || Hernández (1–2) || || 22,364 || 4–11 || |- style="text-align:center; background:#bfb;" | 16 || April 17 || @ Royals || 3–2 || Pineda (2–1) || Francis (0–1) || League (3) || 19,424 || 5–11 || |- style="text-align:center; background:#fbb;" | 17 || April 18 || Tigers || 3–8 || Scherzer (3–0) || Lueke (1–1) || || 12,774 || 5–12 || |- style="text-align:center; background:#bfb;" | 18 || April 19 || Tigers || 13–3 || Fister (1–3) || Coke (1–3) || || 12,411 || 6–12 || |- style="text-align:center; background:#fbb;" | 19 || April 20 || Tigers || 2–3 || Porcello (1–2) || Bédard (0–4) || Valverde (4) || 13,339 || 6–13 || |- style="text-align:center; background:#bfb;" | 20 || April 21 || Athletics || 1–0 || Hernández (2–2) || McCarthy (1–1) || League (4) || 12,770 || 7–13 || |- style="text-align:center; background:#bfb;" | 21 || April 22 || Athletics || 4–0 || Pineda (3–1) || Ross (1–2) || League (5) || 17,798 || 8–13 || |- style="text-align:center; background:#fbb;" | 22 || April 23 || Athletics || 1–9 || Cahill (3–0) || Vargas (0–2) || || 25,355 || 8–14 || |- style="text-align:center; background:#fbb;" | 23 || April 24 || Athletics || 2–5 || Anderson (2–1) || Laffey (0–1) || Fuentes (6) || 16,530 || 8–15 || |- style="text-align:center; background:#bfb;" | 24 ||