|| 1–2 |- bgcolor="ffbbbb" | 4 || April 4 || @ Orioles || L 5–1 || Arrieta (1–0) || Porcello (0–1) || || 46,593 || 1–3 |- bgcolor="bbffbb" | 5 || April 6 || @ Orioles || W 7–3 || Verlander (1–0) || Bergesen (0–1) || || 12,451 || 2–3 |- bgcolor="ffbbbb" | 6 || April 7 || @ Orioles || L 9–5 || Johnson (1–0) || Thomas (0–1) || || 11,648 || 2–4 |- bgcolor="bbffbb" | 7 || April 8 || Royals || W 5–2 || Scherzer (2–0) || Davies (0–1) || Valverde (2) || 44,799 || 3–4 |- bgcolor="ffbbbb" | 8 || April 9 || Royals || L 3–1 || Chen (1–0) || Coke (0–2) || Soria (2) || 33,810 || 3–5 |- bgcolor="ffbbbb" | 9 || April 10 || Royals || L 9–5 || Hochevar (1–1) || Porcello (0–2) || Soria (3) || 28,984 || 3–6 |- bgcolor="ffbbbb" | 10 || April 11 || Rangers || L 2–0 || Ogando (2–0) || Verlander (1–1) || Feliz (4) || 18,724|| 3–7 |- bgcolor="bbffbb" | 11 || April 12 || Rangers || W 5–4 || Valverde (1–0) || O'Day (0–1) || || 20,609 || 4–7 |- bgcolor="bbffbb" | 12 || April 13 || Rangers || W 3–2|| Valverde (2–0) || Oliver (1–1) || || 20,526|| 5–7 |- bgcolor="bbffbb" | 13 || April 14 || @ Athletics || W 3–0 || Coke (1–2) || Ross (1–1) || Valverde (3) || 11,129 || 6–7 |- bgcolor="bbffbb" | 14 || April 15 || @ Athletics || W 8–4 (10) || Villarreal (1–0) || Fuentes (0–2) || || 21,853 || 7–7 |- bgcolor="ffbbbb" | 15 || April 16 || @ Athletics || L 6–2 || Braden (1–1) || Verlander (1–2) || || 16,265 || 7–8 |- bgcolor="ffbbbb" | 16 || April 17 || @ Athletics ||L 5–1 || Cahill (2–0) || Penny (0–2) || || 16,460 || 7–9 |- bgcolor="bbffbb" | 17 || April 18 || @ Mariners || W 8–3 || Scherzer (3–0) || Lueke (1–1) || || 12,774 || 8–9 |- bgcolor="ffbbbb" | 18 || April 19 || @ Mariners || L 13–3 || Fister (1–3) || Coke (1–3) || || 12,411 || 8–10 |- bgcolor="bbffbb" | 19 || April 20 || @ Mariners || W 3–2 || Porcello (1–2) || Bédard (0–4) || Valverde (4) || 13,339|| 9–10 |- bgcolor="bbffbb" | 20 || April 22 || White Sox || W