19 || @ Reds || 5–4 || Galarraga (3–0) || LeCure (0–1) || Putz (4) || 12,994 || 7–8 |- align="center" bgcolor="bbffbb" |16|| April 20 || @ Reds || 3–1 || Kennedy (2–1) || Arroyo (2–2) || Putz (5) || 14,915 || 8–8 |- align="center" bgcolor="ffbbbb" |17|| April 21 || @ Reds || 4–7 || Leake (3–0) || Hudson (0–4) || || 17,319 || 8–9 |- align="center" bgcolor="ffbbbb" |18|| April 22 || @ Mets || 1–4 || Pelfrey (1–2) || Vásquez (0–1) || Rodríguez (3) || 26,546 || 8–10 |- align="center" bgcolor="ffbbbb" |19|| April 23 || @ Mets || 4–6 || Gee (2–0) || Enright (0–2) || Rodríguez (4) || 25,581 || 8–11 |- align="center" bgcolor="ffbbbb" |20|| April 24 || @ Mets || 4–8 || Niese (1–3) || Galarraga (3–1) || || 22,232 || 8–12 |- align="center" bgcolor="bbffbb" |21|| April 25 || Phillies || 4–0 || Kennedy (3–1) || Lee (2–2) || || 19,586 || 9–12 |- align="center" bgcolor="bbffbb" |22|| April 26 || Phillies || 7–5 || Hudson (1–4) || Oswalt (3–1) || || 19,037 || 10–12 |- align="center" bgcolor="ffbbbb" |23|| April 27 || Phillies || 4–8 || Hamels (3–1) || Saunders (0–3) || || 21,825 || 10–13 |- align="center" bgcolor="bbffbb" |24|| April 28 || Cubs || 11–2 || Enright (1–2) || Dempster (1–3) || || 21,716 || 11–13 |- align="center" bgcolor="ffbbbb" |25|| April 29 || Cubs || 2–4 || Zambrano (3–1) || Galarraga (3–2) || Mármol (6) || 29,431 || 11–14 |- align="center" bgcolor="ffbbbb" |26|| April 30 || Cubs || 3–5 || Garza (1–3) || Putz (0–1) || Mármol (7) || 27,652 || 11–15 |- |- bgcolor="ffbbbb" |- align="center" bgcolor="bbffbb" | 27 || May 1 || Cubs || 4–3 || Hudson (2–4) || Coleman (1–2) || Putz (6) || 26,605 || 12–15 |- align="center" bgcolor="bbffbb" | 28 || May 3 || Rockies || 4–3 || Hernandez (1–0) || Paulino (0–1) || Putz (7) || 18,887 || 13–15 |- align="center" bgcolor="ffbbbb" | 29 || May 4 || Rockies || 4–6 || Chacin (4–2) || Enright (1–3) || Street (11) || 18,803 || 13–16 |- align="center" bgcolor="bbffbb" | 30 || May 5 || Rockies || 3–2 (11)|| Hernandez (2–0) || Belisle (2–2) || – || 18,695 || 14–16 |- align="center" bgcolor="ffbbbb" | 31 || May 6 || @ Padres || 3–4 (11)|| Qualls (1–2) || Demel (1–2) || – || 30,878 || 14–17 |- align="center" bgcolor="bbffbb" | 32 || May 7