|| 8–1 || Baker (4–4) || Lewis (5–7) || || 40,420 || 25–39 |- style="text-align:center; background:#bfb;" | 65 || June 12 || Rangers || 6–1 || Liriano (4–6) || Harrison (5–6) || || 39,281 || 26–39 |- style="text-align:center; background:#bbb;" | || June 14 || White Sox || colspan=6 | Postponed (rain); Makeup: 9/5 |- style="text-align:center; background:#bfb;" | 66 || June 15 || White Sox || 4–1 || Pavano (4–5) || Floyd (6–6) || || 37,437 || 27–39 |- style="text-align:center; background:#bfb;" | 67 || June 16 || White Sox || 1–0 || Blackburn (6–4) || Buehrle (6–5) || Capps (9) || 39,484 || 28–39 |- style="text-align:center; background:#bfb;" | 68 || June 17 || Padres || 6–5 || Duensing (4–6) || Richard (2–9) || Capps (10) || 39,205 || 29–39 |- style="text-align:center; background:#bfb;" | 69 || June 18 || Padres || 1–0 || Baker (5–4) || Stauffer (2–5) || Capps (11) || 40,225 || 30–39 |- style="text-align:center; background:#bfb;" | 70 || June 19 || Padres || 5–4 || Burnett (2–4) || Qualls (3–3) || || 40,655 || 31–39 |- style="text-align:center; background: #bfb" | 71 || June 21 || @ Giants || 9–2 || Pavano (5–5) || Bumgarner (3–9) || || 41,958 || 32–39 |- style="text-align:center; background:#fbb;" | 72 || June 22 || @ Giants || 5–1 || Vogelsong (5–1) || Blackburn (6–5) || || 41,886 || 32–40 |- style="text-align:center; background:#fbb;" | 73 || June 23 || @ Giants || 2–1 || Lincecum (6–6) || Duensing (4–7) || Wilson (21) || 42,481 || 32–41 |- style="text-align:center; background:#fbb;" | 74 || June 24 || @ Brewers || 4–3 || Wolf (6–4) || Baker (5–5) || Axford (20) || 39,819 || 32–42 |- style="text-align:center; background:#fbb;" | 75 || June 25 || @ Brewers || 11–1 || Gallardo (9–4) || Liriano (4–7) || || 43,980 || 32–43 |- style="text-align:center; background:#fbb;" | 76 || June 26 || @ Brewers || 6–2 || Narveson (5–5) || Pavano (5–6) || || 41,624 || 32–44 |- style="text-align:center; background:#fbb;" | 77 || June 27 || Dodgers || 15–0 || Billingsley (7–6) || Blackburn (6–6) || || 39,487 || 32–45 |- style="text-align:center; background:#bfb;" | 78 || June 28 || Dodgers || 6–4 || Duensing (5–7) || Lilly (5–8) || Capps (12) || 39,755 || 33–45 |- style="text-align:center; background:#bfb;" | 79 || June 29 || Dodgers || 1–0 || Baker (6–5) || De La Rosa (3–3) || Capps (13) || 39,655 || 34–45