Matt Harrison (4–4) || Roy Oswalt (3–2) || Neftalí Feliz (9) || 45,633 || 24–23 || |- align="center" bgcolor="#bbffbb" | 48 || May 23 || White Sox || 4–0 || Alexi Ogando (5–0) || John Danks (0–7) || || 30,861 || 25–23 || |- align="center" bgcolor="#ffbbbb" | 49 || May 24 || White Sox || 6–8 || Tony Peña (1–1) || Brett Tomko (0–1) || Sergio Santos (7) || 35,524 || 25–24 || |- align="center" bgcolor="#bbffbb" | 50 || May 25 || White Sox || 2–1 || C. J. Wilson (5–3) || Gavin Floyd (5–4) || Neftalí Feliz (10) || 32,382 || 26–24 || |- align="center" bgcolor="#ffbbbb" | 51 || May 27 || Royals || 7–12 (14) || Blake Wood (2–0) || Dave Bush (0–1) || || 39,390 || 26–25 || |- align="center" bgcolor="#bbffbb" | 52|| May 28 || Royals || 10–1 || Matt Harrison (5–4) || Sean O'Sullivan (2–4) || Yoshinori Tateyama (1)|| 40,240 || 27–25 || |- align="center" bgcolor="#bbffbb" | 53 || May 29 || Royals || 7–6 || Arthur Rhodes (3–2) || Joakim Soria (3–2) || || 45,011 || 28–25 || |- align="center" bgcolor="#bbffbb" | 54 || May 30 || @ Rays || 11–5 || Derek Holland (4–1) || Wade Davis (4–5) || || 14,203 || 29–25 || |- align="center" bgcolor="#ffbbbb" | 55 || May 31 || @ Rays || 4–5 || Joel Peralta (2–3) || Arthur Rhodes (3–3) || Kyle Farnsworth (10) || 12,783 || 29–26 || |- |- bgcolor="ffbbbb" |- align="center" bgcolor="#bbffbb" | 56 || June 1 || @ Rays || 3–0 || Colby Lewis (5–5) || David Price (6–5) || Neftalí Feliz (11) || 13,725 || 30–26 || |- align="center" bgcolor="#bbffbb" | 57 || June 2 || @ Indians || 7–4 || Michael Kirkman (1–0) || Carlos Carrasco (4–3) || Neftalí Feliz (12) || 15,336 || 31–26 || |- align="center" bgcolor="#bbffbb" | 58 || June 3 || @ Indians || 11–2 || Alexi Ogando (6–0) || Justin Masterson (5–4) || || 27,458 || 32–26 || |- align="center" bgcolor="#bbffbb" | 59 || June 4 || @ Indians || 4–0 || Derek Holland (5–1) || Fausto Carmona (3–7) || || 30,130 || 33–26 || |- align="center" bgcolor="#bbffbb" | 60 || June 5 || @ Indians || 2–0 || C. J. Wilson (6–3) || Mitch Talbot (2–2) || Neftalí Feliz (13) || 20,621 || 34–26 || |- align="center" bgcolor="#ffbbbb" | 61 || June 6 || Tigers ||