Orioles || 11–0 || Arrieta (2–1) || Pavano (1–2) || || 12,045 || 6–11 |- style="text-align:center; background:#fbb;" | 18 || April 20 || @ Orioles || 5–4 || Britton (3–1)|| Blackburn (1–3) || Gregg (2) || 13,825 || 6–12 |- style="text-align:center; background:#bfb;" | 19 || April 21 || @ Orioles || 3–1 || Baker (1–2) || Guthrie (1–3) || Capps (3) || 16,769 || 7–12 |- style="text-align:center; background:#bbb;" | || April 22 || Indians || colspan=6 | Postponed (rain); Makeup: 7/18 |- style="text-align:center; background:#bfb;" | 20 || April 23 || Indians || 10–3 || Duensing (2–0) || Carmona (1–3) || || 39,459 || 8–12 |- style="text-align:center; background:#bfb;" | 21 || April 24 || Indians || 4–3 || Pavano (2–2) || Pérez (2–1) || Capps (4) || 39,388 || 9–12 |- style="text-align:center; background:#bbb;" | || April 26 || Rays || colspan=6 | Postponed (rain); Makeup: 4/28 |- style="text-align:center; background:#fbb;" | 22 || April 27 || Rays || 8–3 || Davis (3–2) || Liriano (1–4) || || 36,714 || 9–13 |- style="text-align:center; background:#fbb;" | 23 || April 28 || Rays || 15–3 || Hellickson (2–2) || Blackburn (1–4) || || 38,215 || 9–14 |- style="text-align:center; background:#fbb;" | 24 || April 28 || Rays || 6–1 || Niemann (1–3) || Swarzak (0–1) || || 36,456|| 9–15 |- style="text-align:center; background:#fbb;" | 25 || April 29 || @ Royals || 4–3 || Wood (1–0) || Burnett (0–1) || Soria (6) || 31,407 || 9–16 |- style="text-align:center; background:#fbb;" | 26 || April 30 || @ Royals || 11–2 || Adcock (1–0) || Duensing (2–1) || || 22,099 || 9–17 |- |- style="text-align:center; background:#fbb;" | 27 || May 1 || @ Royals || 10–3 || Hochevar (3–3) || Pavano (2–3) || || 18,108 || 9–18 |- style="text-align:center; background:#bfb;" | 28 || May 3 || @ White Sox || 1–0 || Liriano† (2–4) || Jackson (2–4) || || 20,901 || 10–18 |- style="text-align:center; background:#bfb;" | 29 || May 4 || @ White Sox || 3–2 || Blackburn (2–4) || Danks (0–5) || Capps (5) || 18,028 || 11–18 |- style="text-align:center; background:#bfb;" | 30 || May 6 || @ Red Sox || 9–2 || Baker (2–2) || Wakefield (0–1) || || 37,798 || 12–18 |- style="text-align:center; background:#fbb;" | 31 || May 7 || @ Red Sox || 4–0 || Buchholz (3–3) || Duensing (2–2) || || 37,234 || 12–19 |- style="text-align:center; background:#fbb;" | 32 || May 8 || @