(2–1) || Francis (0–1) || League (3) || 19,424 || 10–5 |- bgcolor="ffbbbb" | 16 || April 18|| Cleveland Indians || L 3–7 (10) || Smith (1–0) || Collins (1–1) || || 12,214 || 10–6 |- bgcolor="bbffbb" | 17 || April 19|| Cleveland Indians || W 5–4 || Chen (3–0) || Gómez (0–1) || Soria (5) || 10,506 || 11–6 |- bgcolor="ffbbbb" | 18 || April 20|| Cleveland Indians || L 5–7 || Masterson (4–0) || Hochevar (2–2) || Perez (6) || 10,080 || 11–7 |- bgcolor="bbffbb" | 19 || April 21|| Cleveland Indians || W 3–2 || Crow (2–0) || Perez (0–1) || || 9,279 || 12–7 |- bgcolor="ffbbbb" | 20 || April 22|| @ Texas Rangers || L 6–11 || Holland (3–1) || Francis (0–2) || || 45,769 || 12–8 |- bgcolor="ffbbbb" | 21 || April 23|| @ Texas Rangers || L 1–3 || Ogando (3–0) || Davies (1–2) || Oliver (1) || 45,506 || 12–9 |- bgcolor="ffbbbb" | 22 || April 24|| @ Texas Rangers || L 8–7 || Wilson (3–0) || Chen (3–1) || Rhodes (1) || 28,284 || 12–10 |- bgcolor="ffbbbb" | 23 || April 26|| @ Cleveland Indians || L 4–9 || Masterson (5–0) || Hochevar (2–3) || || 9,650 || 12–11 |- bgcolor="ffbbbb" | 24 || April 27|| @ Cleveland Indians || L 2–7 || Tomlin (4–0) || Francis (0–3) || || 9,722 || 12–12 |- bgcolor="ffbbbb" | 25 || April 28|| @ Cleveland Indians || L 2–8 || Carmona (2–3) || Davies (1–3) || || 9,076 || 12–13 |- bgcolor="bbffbb" | 26 || April 29|| Minnesota Twins || W 4–3 || Wood (1–0) || Burnett (0–1) || Soria (6) || 31,407 || 13–13 |- bgcolor="bbffbb" | 27 || April 30|| Minnesota Twins || W 11–2 || Adcock (1–0) || Duensing (2–1) || || 22,099 || 14–13 |- |- bgcolor="bbffbb" | 28 || May 1|| Minnesota Twins || W 10–3 || Hochevar (3–3) || Pavano (2–3) || || 18,108 || 15–13 |- bgcolor="bbffbb" | 29 || May 3|| Baltimore Orioles || W 6–5 10 || Collins (2–1) || Berken (0–2) || || 11,986 || 16–13 |- bgcolor="ffbbbb" | 30 || May 4|| Baltimore Orioles || L 2–3 || Arrieta (4–1) || Davies (1–4) || Gregg (6) || 11,130 || 16–14 |- bgcolor="bbffbb" | 31 || May 5|| Baltimore Orioles || W 9–1 || Chen (4–1) || Tillman (1–3) || || 29,927 || 17–14