Orioles || 4–1 || Britton (7–9) || Pavano (6–10) || Gregg (18) || 38,986 || 55–72 |- style="text-align:center; background:#fbb;" | 128 || August 23 || Orioles || 8–1 || Simón (4–6) || Duensing (8–13) || || 38,786 || 55–73 |- style="text-align:center; background:#fbb;" | 129 || August 24 || Orioles || 6–1 || Guthrie (6–16) || Slowey (0–2) || || 37,778 || 55–74 |- style="text-align:center; background:#fbb;" | 130 || August 25 || Orioles || 6–1 || Reyes (7–10) || Swarzak (3–4) || || 38,406 || 55–75 |- style="text-align:center; background:#fbb;" | 131 || August 26 || Tigers || 8–1 || Porcello (12–8) || Diamond (0–2) || || 38,918 || 55–76 |- style="text-align:center; background:#fbb;" | 132 || August 27 || Tigers || 6–4 || Verlander (20–5) || Pavano (6–11) || Valverde (39) || 40,179 || 55–77 |- style="text-align:center; background:#bfb;" | 133 || August 28 || Tigers || 11–4 || Duensing (9–13) || Penny (9–10) || || 39,130 || 56–77 |- style="text-align:center; background:#fbb;" | 134 || August 29 || @ White Sox || 3–0 || Buehrle (11–6) || Slowey (0–3) || Santos (27) || 24,120 || 56–78 |- style="text-align:center; background:#fbb;" | 135 || August 30 || @ White Sox || 8–6 || Ohman (1–3) || Swarzak (3–5) || Santos (28) || 21,632 || 56–79 |- style="text-align:center; background:#bfb;" | 136 || August 31 || @ White Sox || 7–6 || Diamond (1–2) || Peavy (6–7) || Nathan (12) || 20,346 || 57–79 |- |- style="text-align:center; background:#bfb;" | 137 || September 2 || @ Angels || 13–5 || Pavano (7–11) || Chatwood (6–10) || || 37,198 || 58–79 |- style="text-align:center; background:#fbb;" | 138 || September 3 || @ Angels || 10–6 || Weaver (16–7) || Dumatrait (1–3) || || 39,102 || 58–80 |- style="text-align:center; background:#fbb;" | 139 || September 4 || @ Angels || 4–1 || Piñeiro (6–6) || Slowey (0–4) || Walden (28) || 36,638 || 58–81 |- style="text-align:center; background:#fbb;" | 140 || September 5 || White Sox || 2–1 || Humber (9–8) || Swarzak (3–6) || Sale (6) || 40,252 || 58–82 |- style="text-align:center; background:#fbb;" | 141 || September 5 || White Sox || 4–0 || Stewart (2–3) || Diamond (1–3) || || 39,849 || 58–83 |- style="text-align:center; background:#fbb;" | 142 || September 6 || White Sox || 3–0 || Peavy (7–7) || Hendriks (0–1) || Santos (29) || 36,959 || 58–84 |- style="text-align:center; background:#bfb;" | 143 || September 7 || White Sox ||