| 112 || August 5 || White Sox || 5–3 || Buehrle (9–5) || Blackburn (7–9) || Sale (3) || 41,364 || 51–61 |- style="text-align:center; background:#fbb;" | 113 || August 6 || White Sox || 6–1 || Stewart (1–1) || Pavano (6–9) || || 41,030 || 51–62 |- style="text-align:center; background:#fbb;" | 114 || August 7 || White Sox || 7–0 || Peavy (5–5) || Duensing (8–v10) || || 39,353 || 51–63 |- style="text-align:center; background:#fbb;" | 115 || August 8 || Red Sox || 8–6 || Aceves (8–1) || Perkins (3–2) || Papelbon (25) || 40,080 || 51–64 |- style="text-align:center; background:#fbb;" | 116 || August 9 || Red Sox || 4–3 || Albers (4–3) || Capps (3–6) || Papelbon (26) || 39,974 || 51–65 |- style="text-align:center; background:#bfb;" | 117 || August 10 || Red Sox || 5–2 || Perkins (4–2) || Lester (11–6) || Nathan (9) || 40,491 || 52–65 |- style="text-align:center; background:#fbb;" | 118 || August 12 || @ Indians || 3–2 || R. Perez (5–2) || Perkins (4–3) || C. Perez (24) || 31,364 || 52–66 |- style="text-align:center; background:#fbb;" | 119 || August 13 || @ Indians || 3–1 || Tomlin (12–5) || Duensing (8–11) || C. Perez (25) || 30,619 || 52–67 |- style="text-align:center; background:#bbb;" | || August 14 || @ Indians || colspan=6 | Postponed (rain); Makeup: 9/24 |- style="text-align:center; background:#bfb;" | 120 || August 15 || @ Tigers || 9–6 || Liriano (8–9) || Porcello (11–8) || Nathan (10) || 36,211 || 53–67 |- style="text-align:center; background:#fbb;" | 121 || August 16 || @ Tigers || 7–1 || Verlander (18–5) || Blackburn (7–10) || || 40,589 || 53–68 |- style="text-align:center; background:#bfb;" | 122 || August 17 || @ Tigers || 6–5 || Capps (4–6) || Valverde (2–4) || Nathan (11) || 34,835 || 54–68 |- style="text-align:center; background:#fbb;" | 123 || August 18 || Yankees || 8–4 || Sabathia (17–7) || Duensing (8–12) || || 41,126 || 54–69 |- style="text-align:center; background:#fbb;" | 124 || August 19 || Yankees || 8–1 || Hughes (4–4) || Slowey (0–1) || || 41,328 || 54–70 |- style="text-align:center; background:#bfb;" | 125 || August 20 || Yankees || 9–4 || Liriano (9–9) || Burnett (9–10) || || 41,254 || 55–70 |- style="text-align:center; background:#fbb;" | 126 || August 21 || Yankees || 3–0 || Nova (13–4) || Dumatrait (1–2) || Rivera (33) || 41,242 || 55–71 |- style="text-align:center; background:#fbb;" | 127 || August 22 ||