|| Bell (33) || 18,403 || 57–67 |- align="center" bgcolor="ffbbbb" | 125 || August 19 || @ Padres || 3–4 || LeBlanc (2–2) || Volstad (5–10) || Bell (34) || 26,065 || 57–68 |- align="center" bgcolor="ffbbbb" | 126 || August 20 || @ Padres || 1–14 || Harang (12–3) || Hensley (1–5) || || 37,268 || 57–69 |- align="center" bgcolor="ffbbbb" | 127 || August 21 || @ Padres || 3–4 || Bell (3–4) || Mujica (8–5) || || 40,065 || 57–70 |- align="center" bgcolor="ffbbbb" | 128 || August 23 || Reds || 6–8 || Chapman (3–1) || Núñez (1–4) || Cordero (27) || 21,204 || 57–71 |- align="center" bgcolor="bbffbb" | 129 || August 24 || Reds || 6–5 || Webb (2–4) || Arredondo (3–4) || Cishek (2) || N/A || 58–71 |- align="center" bgcolor="ffbbbb" | 130 || August 24 || Reds || 2–3 || Arroyo (8–10) || Volstad (5–11) || Cordero (28) || 22,505 || 58–72 |- align="center" bgcolor="bbbbbb" | – || August 25 || Reds ||colspan=6| Postponed; Played on 8/24 |- align="center" bgcolor="bbffbb" | 131 || August 26 || @ Phillies || 6–5 || Hensley (1–5) || Oswalt (6–8) || Cishek (3) || 45,523 || 59–72 |- align="center" bgcolor="bbbbbb" | – || August 27 || @ Phillies ||colspan=6| Postponed (Hurricane Irene); Makeup: September 15 as part of a doubleheader |- align="center" bgcolor="bbbbbb" | – || August 28 || @ Phillies ||colspan=6| Postponed (Hurricane Irene); Makeup: September 15 as part of a doubleheader |- align="center" bgcolor="ffbbbb" | 132 || August 29 || @ Mets || 1–2 || Dickey (6–11) || Sánchez (7–7) || Parnell (2) || N/A || 59–73 |- align="center" bgcolor="ffbbbb" | 133 || August 29 || @ Mets || 1–5 || Gee (12–5) || Nolasco (9–10) || || 29,335 || 59–74 |- align="center" bgcolor="bbffbb" | 134 || August 30 || @ Mets || 6–0 || Vázquez (8–11) || Pelfrey (7–11) || || 30,806 || 60–74 |- align="center" bgcolor="ffbbbb" | 135 || August 31 || @ Mets || 2–3 || Acosta (2–1) || Volstad (5–12) || Parnell (3) || 27,905 || 60–75 |- |- bgcolor="ffbbbb" |- align="center" bgcolor="ffbbbb" | 136 || September 1 || @ Mets || 5–7 || Batista (4–2) || Hensley (2–6) || Parnell (4) || 27,562 || 60–76 |- align="center" bgcolor="ffbbbb" | 137 || September 2 || Phillies || 3–5 || Oswalt (7–8) || Hand (1–5) || Madson (27) || 21,659 || 60–77 |- align="center" bgcolor="bbffbb"