|| Royals || 3–1 || Alexi Ogando (3–0) || Kyle Davies (1–2) || Darren Oliver (1) || 45,506 || 13–7 || |- align="center" bgcolor="#bbffbb" | 21 || April 24 || Royals || 8–7 || C. J. Wilson (3–0) || Bruce Chen (3–1) || Arthur Rhodes (1) || 28,284 || 14–7 || |- align="center" bgcolor="#ffbbbb" | 22 || April 25 || Blue Jays || 4–6 || Kyle Drabek (2–0) || Colby Lewis (1–3) || Jon Rauch (4) || 22,915 || 14–8 || |- align="center" bgcolor="#ffbbbb" | 23 || April 26 || Blue Jays || 3–10 || Jesse Litsch (2–1) || Matt Harrison (3–2) || || 21,755 || 14–9 || |- align="center" bgcolor="#bbffbb" | 24 || April 27 || Blue Jays || 7–6 || Cody Eppley (1–0) || Octavio Dotel (1–1) || Darren Oliver (2) || 29,322 || 15–9 || |- align="center" bgcolor="#ffbbbb" | 25 || April 28 || Blue Jays || 2–5 || Frank Francisco (1–0) || Darren Oliver (1–2) || || 24,121 || 15–10 || |- align="center" bgcolor="#ffbbbb" | 26 || April 29 || @ Athletics || 1–3 || Trevor Cahill (4–0) || C. J. Wilson (3–1) || Brian Fuentes (7) || 17,226 || 15–11 || |- align="center" bgcolor="#bbffbb" | 27 || April 30 || @ Athletics || 11–2 || Colby Lewis (2–3) || Brett Anderson (2–2) || || 27,285 || 16–11 || |- |- bgcolor="ffbbbb" |- align="center" bgcolor="#ffbbbb" | 28 || May 1 || @ Athletics || 2–7 || Gio González (3–2) || Matt Harrison (3–3) || || 15,178 || 16–12 || |- align="center" bgcolor="#ffbbbb" | 29 || May 2 || @ Athletics || 4–5 (10) || Grant Balfour (2–1) || Darren Oliver (1–3) || || 9,193 || 16–13 || |- align="center" bgcolor="#ffbbbb" | 30 || May 3 || @ Mariners || 3–4 || David Pauley (1–0) || Pedro Strop (0–1) || Brandon League (8) || 12,759 || 16–14 || |- align="center" bgcolor="#bbffbb" | 31 || May 4 || @ Mariners || 5–2 || C. J. Wilson (4–1) || Michael Pineda (4–2) || || 13,896 || 17–14 || |- align="center" bgcolor="#ffbbbb" | 32 || May 5 || @ Mariners || 1–3 || Jason Vargas (2–2) || Colby Lewis (2–4) || Brandon League (9) || 14,205 || 17–15 || |- align="center" bgcolor="#ffbbbb" | 33 || May 6 || Yankees || 1–4 || Iván Nova (3–2) || Matt Harrison (3–4) || Mariano Rivera (12) || 49,069 || 17–16 || |- align="center"