place qualifying effort and leading 5 laps on his way to a 5th place finish at Fontana, Karam captured his season-best finish at the 2015 Iowa Corn 300 at Iowa Speedway in July, by finishing 3rd. In his Pennsylvania homecoming at Pocono Raceway for the 2015 ABC Supply 500 on August 23, Karam was leading with 21 laps remaining when he lost control exiting turn 1, eliminating his Chip Ganassi number 8 Dallara as it spun and crashed hard into the wall. Debris strewn from Karam's disintegrating car made contact with fellow competitor Justin Wilson's helmet, sending him into the infield wall where the safety team extracted him unconscious and unresponsive, necessitating an emergency medevac to Lehigh Valley Hospital–Cedar Crest in Allentown where Wilson lay comatose, in critical condition. Wilson succumbed to his injuries on August 24, 2015. With Saavedra back in the car for the 2015 season finale at Sonoma, Karam finished the 2015 IndyCar season 20th in points, bested by rival Gabby Chaves for 2015 rookie of the year honors. Replaced for the 2016 season, Karam's seat in the Chip Ganassi stable piloting the number 8 Dallara was secured by Max Chilton. On a one-race agreement for 2016, Dreyer & Reinbold signed Karam for the Indianapolis 500, initially with Havoline and Gas Monkey Garage as sponsors. Steadily improving from his 23rd qualifying slot on grid, into the top 10, Karam crashed on lap 94, going into Townsend Bell in Turn One. On a successive one-race agreement, again Dreyer & Reinbold signed Karam to drive the Mecum Auctions No. 24 Dallara-Chevrolet for the 2017 Indianapolis 500. Having improved from his 21st qualifying slot into the top 10, Karam retired his Mecum Auctions Dreyer & Reinbold entry at the 275-mile juncture, with a dead battery. He joined the team again in 2018, sponsored by Wix, but crashed the car on lap 154. In 2019, he again drove for Dreyer & Reinbold in the 2019 Indianapolis 500. He started 31st and finished 19th. It was announced on July 2, 2019 that Karam would drive for Carlin in the Honda Indy Toronto. On January 7, 2020, Dreyer & Reinbold Racing announced that they would be expanding their race schedule to at least four races with Karam driving them. These races include the Firestone Grand Prix of St. Petersburg, GMR Grand Prix, 2020 Indianapolis 500, and Honda Indy Toronto. A pit error in