13,825 || 8–9 |- style="text-align:center; background:#fbb;" | 18 || April 21 || Twins || 1–3 || Baker (1–2) || Guthrie (1–3) || Capps (3) || 16,769 || 8–10 |- style="text-align:center; background:#bbb;" | – || April 22 || Yankees || colspan=6| Postponed (rain); Makeup: August 27 as part of a doubleheader |- style="text-align:center; background:#fbb;" | 19 || April 23 || Yankees || 3–15 || Sabathia (1–1) || Bergesen (0–3) || || 39,054 || 8–11 |- style="text-align:center; background:#fbb;" | 20 || April 24 || Yankees || 3–6 (11) || Logan (1–1) || Berken (0–1) || || 25,051 || 8–12 |- style="text-align:center; background:#cfc;" | 21 || April 26 || Red Sox || 4–1 || Britton (4–1) || Buchholz (1–3) || Gregg (3) || 18,938 || 9–12 |- style="text-align:center; background:#cfc;" | 22 || April 27 || Red Sox || 5–4 || Uehara (1–0) || Bard (0–3) || Gregg (4) || 15,514 || 10–12 |- style="text-align:center; background:#fbb;" | 23 || April 28 || Red Sox || 2–6 || Lester (3–1) || Johnson (1–1) || || 21,209 || 10–13 |- style="text-align:center; background:#cfc;" | 24 || April 29 || @ White Sox || 10–4 || Arrieta (3–1) || Danks (0–4) || || 21,816 || 11–13 |- style="text-align:center; background:#cfc;" | 25 || April 30 || @ White Sox || 6–2 || Tillman (1–2) || Humber (2–3) || || 26,104 || 12–13 |- |- style="text-align:center; background:#cfc;" | 26 || May 1 || @ White Sox || 6–4 || Britton (5–1) || Floyd (3–2) || Gregg (5) || 22,029 || 13–13 |- style="text-align:center; background:#fbb;" | 27 || May 2 || @ White Sox || 2–6 || Buehrle (2–3) || Guthrie (1–4) || Santos (3) || 18,007 || 13–14 |- style="text-align:center; background:#fbb;" | 28 || May 3 || @ Royals || 5–6 || Collins (2–1) || Berken (0–2) || || 11,986 || 13–15 |- style="text-align:center; background:#cfc;" | 29 || May 4 || @ Royals || 3–2 || Arrieta (4–1) || Davies (1–4) || Gregg (6) || 11,130 || 14–15 |- style="text-align:center; background:#fbb;" | 30 || May 5 || @ Royals || 1–9 || Chen (4–1) || Tillman (1–3) || || 29,927 || 14–16 |- style="text-align:center; background:#fbb;" | 31 || May 6 || Rays || 2–6 || Shields (3–1) || Britton (5–2) || || 20,694 || 14–17 |- style="text-align:center; background:#fbb;" | 32 || May 7 || Rays || 2–8 || Hellickson (3–2) || Guthrie (1–5) || || 18,961 || 14–18 |- style="text-align:center;