April 26 || @ Tigers || 7–3 || Hernández (3–2) || Coke (1–4) || || 18,027 || 9–15 || |- style="text-align:center; background:#bfb;" | 25 || April 27 || @ Tigers || 10–1 || Bédard (1–4) || Verlander (2–3) || || 18,153 || 10–15 || |- style="text-align:center; background:#bfb;" | 26 || April 28 || @ Tigers || 7–2 || Pineda (4–1) || Penny (1–3) || || 21,176 || 11–15 || |- style="text-align:center; background:#bfb;" | 27 || April 29 || @ Red Sox || 5–4 || Vargas (1–2) || Jenks (1–2) || League (6) || 37,845 || 12–15 || |- style="text-align:center; background:#bfb;" | 28 || April 30 || @ Red Sox || 2–0 || Fister (2–3) || Lackey (2–3) || League (7) || 37,901 || 13–15 || |- |- style="text-align:center; background:#fbb;" | 29 || May 1 || @ Red Sox || 2–3 || Papelbon (1–0) || Wright (0–1) || || 37,079 || 13–16 || |- style="text-align:center; background:#bfb;" | 30 || May 3 || Rangers || 4–3 || Pauley (1–0) || Strop (0–1) || League (8) || 12,759 || 14–16 || |- style="text-align:center; background:#fbb;" | 31 || May 4 || Rangers || 2–5 || Wilson (4–1) || Pineda (4–2) || || 13,896 || 14–17 || |- style="text-align:center; background:#bfb;" | 32 || May 5 || Rangers || 3–1 || Vargas (2–2) || Lewis (2–4) || League (9) || 14,205 || 15–17 || |- style="text-align:center; background:#bfb;" | 33 || May 6 || White Sox || 3–2 || Hernández (4–2) || Thornton (0–3) || || 31,912 || 16–17 || |- style="text-align:center; background:#fbb;" | 34 || May 7 || White Sox || 0–6 || Floyd (4–2) || Fister (2–4) || || 26,288 || 16–18 || |- style="text-align:center; background:#fbb;" | 35 || May 8 || White Sox || 2–5 (10) || Santos (1–0) || League (0–1) || || 26,074 || 16–19 || |- style="text-align:center; background:#fbb;" | 36 || May 10 || @ Orioles || 6–7 (13) || Accardo (2–0) || League (0–2) || || 11,485 || 16–20 || |- style="text-align:center; background:#fbb;" | 37 || May 11 || @ Orioles || 2–4 || Tillman (2–3) || Hernández (4–3) || Gregg (7) || 11,561 || 16–21 || |- style="text-align:center; background:#fbb;" | 38 || May 12 || @ Orioles || 1–2 (12) || Johnson (2–1) || League (0–3) || || 19,082 || 16–22 || |- style="text-align:center; background:#fbb;" | 39 || May 13 || @ Indians || 4–5 || Sipp (2–0) ||