|| 3–2 || Romero (4–4) || Davis (4–4) || Francisco (5) || 12,590 || 22–21 ||2½ |- style="text-align:center; background:#fbb;" | 44 || May 20 || Astros || 5–2 || López (1–1) ||Francisco (1–1) || Melancon (2) || 15,478 || 22–22 ||2½ |- style="text-align:center; background:#cfc;" | 45 || May 21 || Astros || 7–5 || Janssen (1–0) || Myers (1–4) ||Dotel (1) || 21,494 || 23–22 || 1½ |- style="text-align:center; background:#fbb;" | 46 || May 22 || Astros || 3–2 || Rodríguez (3–3) || Drabek (3–3) || Melancon (3) || 19,487 || 23–23 || 2½ |- style="text-align:center; background:#cfc;" | 47 || May 23 || @ Yankees || 7–3 || Villanueva (2–0) || Colón (2–3) || || 41,946 || 24–23 ||1½ |- style="text-align:center; background:#fbb;" | 48 || May 24 || @ Yankees || 5–4 || Sabathia (5–3) || Francisco (1–2) || || 41,549 || 24–24 || 2½ |- style="text-align:center; background:#fbb;" | 49 || May 25 || @ Yankees || 7–3 || García (3–4) || Reyes (0–4) || || 43,201 || 24–25 || 3½ |- style="text-align:center; background:#fbb;" | 50 || May 26 || White Sox || 3–1 || Crain (2–1) || Rzepczynski (2–1) || Santos (8) || 14,353 || 24–26 || 4 |- style="text-align:center; background:#cfc;" | 51 || May 27 || White Sox || 4–2 || Janssen (2–0) || Buehrle (4–4) || Rauch (6) || 16,668 || 25–26 || 4 |- style="text-align:center; background:#cfc;" | 52 || May 28 || White Sox || 9–8 (14) || Pérez (1–0) || Floyd (5–5) || || 22,659 || 26–26 || 3½ |- style="text-align:center; background:#cfc;" | 53 || May 29 || White Sox || 13–4 || Romero (5–4) || Danks (0–8) || || 18,325 || 27–26 || 3 |- style="text-align:center; background:#cfc;" | 54 || May 30 || Indians || 11–1 || Reyes (1–4) || Carmona (3–6) || || 12,902 || 28–26 || 2 |- style="text-align:center; background:#fbb;" | 55 || May 31 || Indians || 6–3 || Talbot (2–1) || Morrow (2–3) || || 14,556 || 28–27 || 2½ |- |- style="text-align:center; background:#fbb;" | 56 || June 1 || Indians || 13–9 || Tomlin (7–2) || Drabek (3–4) || || 15,397 || 28–28 || 3½ |- style="text-align:center; background:#cfc;" | 57 || June 3 || @ Orioles || 8–4 || Villanueva (3–0) || Britton (5–4) || || 18,587 || 29–28 || 3 |- style="text-align:center; background:#fbb;" | 58 || June 4 || @ Orioles || 5–3 || Arrieta (7–3) || Romero