|- style="text-align:center; background:#bfb;" | 133 || August 31 || Athletics || 4–3 (16) || Herrmann (4–0) || Outman (3–4) || || 15,202 || 68–65 |- |- style="text-align:center; background:#fbb;" | 134 || September 1 || Athletics || 7–0 || Gonzalez (12–11) || Carmona (6–13) || || 14,192 || 68–66 |- style="text-align:center; background:#bfb;" | 135 || September 2 || @ Royals || 5–4 || Masterson (11–8) || Chen (10–6) || C. Perez (31) || 27,251 || 69–66 |- style="text-align:center; background:#fbb;" | 136 || September 3 || @ Royals || 5–1 || Hochevar (10–10) || Huff (2–3) || || 27,126 || 69–67 |- style="text-align:center; background:#bfb;" | 137 || September 4 || @ Royals || 9–6 || Gómez (2–2) || Francis (5–15) || C. Perez (32) || 34,015 || 70–67 |- style="text-align:center; background:#fbb;" | 138 || September 5 || Tigers || 4–2 || Fister (7–13) || Jiménez (2–2) || Valverde (41) || 39,824 || 70–68 |- style="text-align:center; background:#fbb;" | 139 || September 6 || Tigers || 10–1 || Porcello (13–8) || Carmona (6–14) || || 27,544 || 70–69 |- style="text-align:center; background:#fbb;" | 140 || September 7 || Tigers || 8–6 || Verlander (22–5) || Masterson (11–9) || Valverde (42) || 16,783 || 70–70 |- style="text-align:center; background:#fbb;" | 141 || September 8 || @ White Sox || 8–1 || Thornton (1–4) || Huff (2–4) || || 22,063 || 70–71 |- style="text-align:center; background:#bfb;" | 142 || September 9 || @ White Sox || 8–4 || Gómez (3–2) || Buehrle (11–8) || || 26,711 || 71–71 |- style="text-align:center; background:#fbb;" | 143 || September 10 || @ White Sox || 7–3 (10) || Santos (4–4) || C. Perez (3–7) || || 26,719 || 71–72 |- style="text-align:center; background:#bfb;" | 144 || September 11 || @ White Sox || 7–3 || Jiménez (3–2) || Stewart (2–4) || || 22,319 || 72–72 |- style="text-align:center; background:#fbb;" | 145 || September 13 || @ Rangers || 10–4 || Harrison (12–9) || Masterson (11–10) || || 30,107 || 72–73 |- style="text-align:center; background:#fbb;" | 146 || September 14 || @ Rangers || 9–1 || Holland (14–5) || Huff (2–5) || || 38,710 || 72–74 |- style="text-align:center; background:#fbb;" | 147 || September 15 || @ Rangers || 7–4 || Ogando (13–8) || Carmona (6–15) || || 44,242 || 72–75 |- style="text-align:center; background:#bfb;" | 148 || September 16 || @ Twins || 7–6 || Jiménez (4–2) || Slowey (0–6) || C. Perez (33) || 37,942 || 73–75