style="text-align:center; background:#fbb;" |35||May 9||Reds||1–6||Wood (2–3)||A. Rodríguez (0–1)||||20,174||Minute Maid Park||13–22||L3 |- style="text-align:center; background:#fbb;" |36||May 10||Reds||7–3||Bailey (2–0)||Myers (1–3)||||24,499||Minute Maid Park||13–23||L4 |- style="text-align:center; background:#bfb;" |37||May 11||Reds||4–3||Melancon (3–1)||Leake (3–2)||||21,008||Minute Maid Park||14–23||W1 |- style="text-align:center; background:#fbb;" |38||May 13||Mets||4–6||Misch (1–0)||Fulchino (0–1)||Rodríguez (11)||28,791||Minute Maid Park||14–24||L1 |- style="text-align:center; background:#bfb;" |39||May 14||Mets||7–3||Happ (3–4)||Dickey (1–5)||||31,140||Minute Maid Park||15–24||W1 |- style="text-align:center; background:#fbb;" |40||May 15||Mets||4–7||Capuano (3–4)||A. Rodríguez (0–2)||Rodríguez (12)||28,406||Minute Maid Park||15–25||L1 |- style="text-align:center; background:#fbb;" |41||May 16||@Braves||2–3||Hanson (5–3)||Abad (1–4)||Kimbrel (11)||17,416||Turner Field||15–26||L2 |- style="text-align:center; background:#fbb;" |42||May 17||@Braves||1–3 (11)||Gearrin (1–1)||Fulchino (0–2)||||21,085||Turner Field||15–27||L3 |- style="text-align:center; background:#fbb;" |43||May 18||@Cardinals||1–5||Lohse (5–2)||Norris (2–3)||||35,298||Busch Stadium||15–28||L3 |- style="text-align:center; background:#fbb;" |44||May 19||@Cardinals||2–4||McClellan (6–1)||Happ (3–5)||Salas(5)||36,409||Busch Stadium||15–29||L4 |- style="text-align:center; background:#bfb;" |45||May 20||@Blue Jays||5–2||López (1–1)||Francisco (1–1)||Melancon (2)||15,478||Rogers Centre||16–29||W1 |- style="text-align:center; background:#fbb;" |46||May 21||@Blue Jays||5–7||Janssen (1–0)||Myers (1–4)||Dotel (1)||21,494||Rogers Centre||16–30||L1 |- style="text-align:center; background:#bfb;" |47||May 22||@Blue Jays||3–2||W. Rodríguez (3–3)||Drabek (3–3)||Melancon (3)||19,487||Rogers Centre||17–30||W1 |- style="text-align:center; background:#bfb;" |48||May 23||Dodgers||4–3||Fulchino (1–2)||Jansen (1–1)||||22,579||Minute Maid Park||18–30||W2 |- style="text-align:center; background:#fbb;" |49||May 24||Dodgers||4–5||Billingsley (3–4)||Happ (3–6)||||28,713||Minute Maid Park||18–31||L1 |- style="text-align:center; background:#bfb;" |50||May 25||Dodgers||2–1||Melancon (4–1)||Guerrier (2–3)||||21,350||Minute Maid Park||19–31||W1 |- style="text-align:center; background:#fbb;" |51||May 27||Diamondbacks||6–7||Hudson (6–4)||López (1–2)||Putz (15)||21,834||Minute Maid Park||19–32||L1 |- style="text-align:center; background:#fbb;" |52||May 28||Diamondbacks||3–11||Duke (1–0)||Norris (2–4)||||31,405||Minute Maid Park||19–33||L2 |- style="text-align:center; background:#fbb;" |53||May 29||Diamondbacks||2–4||Heilman (4–0)||Fulchino (1–3)||Putz (16)||21,882||Minute Maid Park||19–34||L3 |- style="text-align:center; background:#bfb;" |54||May 30||@Cubs||12–7||Escalona (1–0)||Samardzija (3–1)||||30,450||Wrigley Field||20–34||W1 |- style="text-align:center; background:#bfb;" |55||May 31||@Cubs||7–3||F. Rodriguez (1–0)||Mármol (1–2)||||31,178||Wrigley Field||21–34||W2 |- |- style="text-align:center; background:#bfb;" |56||June 1||@Cubs||3–1||Myers (2–4)||Davis (0–4)||Melancon (4)||31,340||Wrigley Field||22–34||W3 |- style="text-align:center; background:#bfb;" |57||June 2||@Padres||7–4||Norris (3–4)||Stauffer (1–4)||Melancon (5)||16,635||Petco Park||23–34||W4 |- style="text-align:center; background:#fbb;" |58||June 3||@Padres||1–3||Mosley (2–6)||Happ (3–7)||Bell (15)||20,056||Petco Park||23–35||L1 |- style="text-align:center; background:#fbb;" |59||June 4||@Padres||3–6||Harang(6–2)||A. Rodríguez (0–3)||Bell (16)||28,208||Petco Park||23–36||L2 |- style="text-align:center; background:#fbb;" |60||June 5||@Padres||2–7||Latos (4–6)||Lyles (0–1)||||21,958||Petco Park||23–37||L3 |- style="text-align:center; background:#fbb;" |61||June 7||Cardinals||4–7||Westbrook (6–3)||Myers (2–5)||Salas (11)||23,277||Minute Maid Park||23–38||L4 |- style="text-align:center; background:#bfb;" |62||June 8||Cardinals||4–1||Norris (4–4)||García (6–2)||Melancon (6)||22,107||Minute Maid Park||24–38||W1 |- style="text-align:center; background:#fbb;" |63||June 9||Cardinals||2–9||Lynn (1–1)||Happ (3–8)||||24,482||Minute Maid Park||24–39||L1 |- style="text-align:center; background:#fbb;" |64||June 10||Braves||4–11||Hudson (5–5)||A. Rodríguez (0–4)||||29,252||Minute Maid Park||24–40||L2 |- style="text-align:center; background:#fbb;" |65||June 11||Braves||3–6 (10)||Linebrink (2–1)||Lyon (3–3)||||32,117||Minute Maid Park||24–41||L3 |- style="text-align:center; background:#fbb;" |66||June 12||Braves||1–4||Hudson (8–4)||Myers (2–6)||Venters (3)||23,765||Minute Maid Park||24–42||L4 |- style="text-align:center; background:#bfb;" |67||June 13||Braves||8–3||W. Rodríguez (4–3)||Lowe (3–5)||||21,466||Minute Maid Park||25–42||W1 |- style="text-align:center; background:#fbb;" |68||June 14||Pirates||0–1||Karstens (4–4)||Norris (4–5)||Hanrahan (18)||29,712||Minute Maid Park||25–43||L1 |- style="text-align:center; background:#fbb;" |69||June 15||Pirates||3–7||Morton (7–3)||Del Rosario (0–1)||Hanrahan (19)||29,866||Minute Maid Park||25–44||L2 |- style="text-align:center; background:#fbb;" |70||June 16||Pirates||4–5||McDonald (5–4)||Lyles (0–2)||Veras (1)||26,415||Minute Maid Park||25–45||L3 |- style="text-align:center; background:#bfb;" |71||June 17||@Dodgers||7–3||Myers (3–6)||Lilly (5–6)||||35,053||Dodger Stadium||26–45||W1 |- style="text-align:center; background:#bfb;" |72||June 18||@Dodgers||7–0||W. Rodríguez (5–3)||De La Rosa (3–1)||||36,124||Dodger Stadium||27–45||W2 |- style="text-align:center; background:#fbb;" |73||June 19||@Dodgers||0–1||Guerrier (3–3)||López (1–3)||Guerra (2)||44,665||Dodger Stadium||27–46||L1 |- style="text-align:center; background:#fbb;" |74||June 20||@Rangers||3–8||Holland (6–2)||Happ (3–9)||||41,205||Rangers Ballpark in Arlington||27–47||L2 |- style="text-align:center; background:#fbb;" |75||June 21||@Rangers||4–5 (11)||Tateyama (1–0)||Del Rosario (0–2)||||33,533||Rangers Ballpark in Arlington||27–48||L3 |- style="text-align:center; background:#bfb;" |76||June 22||@Rangers||5–3||Melancon (5–1)||Feliz (0–1)||||39,708||Rangers Ballpark in Arlington||28–48||W1