|| 36,972 || 84–62 |- bgcolor="bbffbb" | 147 || September 12 || @ White Sox || W 14–4 || Porcello (14–8) || Danks (6–12)|| || 22,750 || 85–62 |- bgcolor="bbffbb" | 148 || September 13 || @ White Sox || W 5–0 || Verlander (23–5) || Floyd (12–11) || || 25,015 || 86–62 |- bgcolor="bbffbb" | 149 || September 14 || @ White Sox || W 6–5 (10) || Coke (3–9) || Santos (4–5) || Valverde (44) || 19,010 || 87–62 |- bgcolor="ffbbbb" | 150 || September 15 || @ Athletics || L 6–1 || McCarthy (9–8) || Scherzer (14–9) || || 10,925 || 87–63 |- bgcolor="bbffbb" | 151 || September 16 || @ Athletics || W 3–1 || Fister (9–13) || Cahill (11–14) || Valverde (45) || 31,022 || 88–63 |- bgcolor="ffbbbb" | 152 || September 17 || @ Athletics || L 5–3 || Gonzalez (14–12) || Porcello (14–9) || || 19,451 || 88–64 |- bgcolor="bbffbb" | 153 || September 18 || @ Athletics || W 3–0 || Verlander (24–5) || Moscoso (8–9) || Valverde (46) || 18,405 || 89–64 |- bgcolor="ffbbbb" | 154 || September 20 || @ Royals || L 10–2 || Mendoza (1–0) || Penny (10–11) || || 26,953 || 89–65 |- bgcolor="bbffbb" | 155 || September 21 || @ Royals || W 6–3 || Fister (10–13) || Herrera (0–1) || Valverde (47) || 28,776 || 90–65 |- bgcolor="ffbbbb" | 156 || September 22 || Orioles || L 6–5 || Britton (11–10) || Pauley (5–6) || Gregg (21) || 27,847 || 90–66 |- bgcolor="bbffbb" | 157 || September 23 || Orioles || W 4–3 (11) || Perry (1–0) || Eyre (2–2) || || 38,623 || 91–66 |- bgcolor="ffbbbb" | 158 || September 24 || Orioles || L 6–5 || Strop (2–1) || Schlereth (2–2) || Gregg (22) || 44,846|| 91–67 |- bgcolor="bbffbb" | 159 || September 25 || Orioles || W 10–6 || Penny (11–11) || Matusz (1–9) || || 41,051 || 92–67 |- bgcolor="bbffbb" | 160 || September 26 || Indians || W 14–0 || Fister (11–13) || Jiménez (10–13) || || 29,886 || 93–67 |- bgcolor="bbffbb" | 161 || September 27 || Indians || W 9–6 || Scherzer (15–9) || Gómez (5–3) || Valverde (48) || 31,132 || 94–67 |- bgcolor="bbffbb" | 162 || September 28 || Indians || W 5–4 || Perry (2–0) || Pestano (1–2) || Valverde (49) || 31,645|| 95–67 |-