De MTV Movie Awards 2010 vonden plaats op 6 juni 2010 in het Gibson Amphitheatre in Universal City (Californië). De voorstelling werd gepresenteerd door stand-upcomedian en acteur Aziz Ansari.

Winnaars en nominaties

Best Movie (Beste film) 
The Twilight Saga: New Moon
Alice in Wonderland
The Hangover
Harry Potter and the Half-Blood Prince
Avatar

Best Male Performance (Beste mannelijke vertolking) 
Robert Pattinson – The Twilight Saga: New Moon
Zac Efron – 17 Again
Taylor Lautner – The Twilight Saga: New Moon
Daniel Radcliffe – Harry Potter and the Half-Blood Prince
Channing Tatum – Dear John

Best Female Performance (Beste vrouwelijke vertolking) 
Kristen Stewart – The Twilight Saga: New Moon
Sandra Bullock – The Blind Side
Amanda Seyfried – Dear John
Zoë Saldana – Avatar
Emma Watson – Harry Potter and the Half-Blood Prince

Best Breakout Star 
Anna Kendrick – Up in the Air
Quinton Aaron – The Blind Side
Zach Galifianakis – The Hangover
Logan Lerman – Percy Jackson & the Olympians: The Lightning Thief
Chris Pine – Star Trek
Gabourey Sidibe – Precious

Best Villain (Beste schurk) 
Tom Felton – Harry Potter and the Half-Blood PrinceHelena Bonham Carter – Alice in Wonderland
Ken Jeong – The Hangover
Stephen Lang – Avatar
Christoph Waltz – Inglourious Basterds

 Best Comedic Performance (Beste Komische Vertolking) Zach Galifianakis – The Hangover
Sandra Bullock – The Proposal
Bradley Cooper – The Hangover
Ryan Reynolds – The Proposal
Ben Stiller – Night at the Museum: Battle of the Smithsonian

Best Scared-As-S**t Performance 
Amanda Seyfried – Jennifer's Body
Sharlto Copley – District 9
Jesse Eisenberg – Zombieland
Katie Featherston – Paranormal Activity
Alison Lohman – Drag Me to Hell

Best Kiss (Beste kus) 
Kristen Stewart and Robert Pattinson – The Twilight Saga: New MoonSandra Bullock and Ryan Reynolds – The Proposal
Zoë Saldana and Sam Worthington – Avatar
Kristen Stewart and Dakota Fanning – The Runaways
Taylor Swift and Taylor Lautner – Valentine's Day

 Best Fight (Beste gevecht)  Beyoncé Knowles vs. Ali Larter – ObsessedRobert Downey, Jr. vs. Mark Strong – Sherlock Holmes
Hugh Jackman and Liev Schreiber vs. Ryan Reynolds – X-Men Origins: Wolverine
Logan Lerman vs. Jake Abel – Percy Jackson & the Olympians: The Lightning Thief
Sam Worthington vs. Stephen Lang – Avatar

Best WTF Moment 
Naked Trunk Surprise – Ken Jeong (from The Hangover)
Bill Murray?! A Zombie?! – Bill Murray (from Zombieland)
Cops a Feel – Betty White (from The Proposal)
Unexpected Transformation – Isabel Lucas (from Transformers: Revenge of the Fallen)
Vomits a Mysterious Black Ooze – Megan Fox (from Jennifer's Body)

Biggest Badass Star 
Rain
Angelina Jolie
Chris Pine
Channing Tatum
Sam Worthington

Global Superstar (Wereldwijde superster) 
Robert Pattinson
Taylor Lautner
Johnny Depp
Daniel Radcliffe
Kristen Stewart

MTV Generation Award (MTV Generatie Award) 
Sandra Bullock

MTV Movie Awards