text: Talbot was active in politics, being a moderate Reformer who generally supported the Whig Ministers. He served as member of parliament for Chippenham between 1832 and 1835 when he retired from parliament. He also held the office of High Sheriff of Wiltshire in 1840.
  While engaged in his scientific researches, Talbot devoted much time to archaeology. He had a 20-year involvement in the field of Assyriology, the study of the history, archaeology and culture of Mesopotamia (present-day Iraq). With Henry Rawlinson and Edward Hincks he shares the honour of having been one of the first decipherers of the cuneiform inscriptions of Nineveh.  He published Hermes, or Classical and Antiquarian Researches (1838–39), and Illustrations of the Antiquity of the Book of Genesis (1839). He was also the author of English Etymologies (1846).