text: In 1975 Höskuldsson started working at The Regional Computing Centre at Technical University of Denmark as a computer specialist in statistics and production technology. Then, in 1987, he was appointed as an associate professor at Technical University of Denmark. During his professorship he successfully showed that the PLS (Partial Least Squares) algorithm can be a principle in any of a variety of mathematical inequalities asserting a fundamental limit to the precision with which certain pairs of physical properties of a particle known as complementary variables can be known simultaneously. In 1927 Werner Heisenberg stated that the more precisely the position of a particle is determined, the less precisely its momentum can be known, and vice versa. Based on this theory, Höskuldsson’s H-Principle finds a solution in a stepwise way which viewed as maximizing the co-variance between two data sets. Demonstrating that PLS regression is of a similar kind to the well-known canonical correlation in multivariate statistics.
  In 1996 he published "Prediction Methods in Science and Technology", a review of latent structure regression, including PLS regression.
  The following year Höskuldsson received the Herman Wold gold medal from the Swedish Chemical Society at the Scandinavian Symposium on Chemometrics as recognition of his contributions and pioneering work in the field of chemometrics.
  In 2008 Höskuldsson founded SIME Diagnostics, a company focused on digitising healthcare diagnostics and is his current employment.