Some concerns relating to hydrogels infused with nanoparticles are the chances of either bursting, or of incomplete release of drugs. Although hydrogels infused with nanoparticles are speculated to be quite promising methods of drug, protein, peptide, oligosaccharide, vaccine, and nucleic acid delivery, more studies regarding nanotoxicology and safety are required before clinical applications can be pursued. Further, to avoid accumulation, biodegradable gels and nanoparticles are highly desirable.