Boldyreva was awarded an additional Doctorate in Science in solid-state chemistry in 2000. She was promoted to Professor at the Novosibirsk State University in 2003. Her early work considered photomechanical effects in crystals of coordination complexes. She shifted into high pressure research, working with infrared spectroscopy at the Phillips University in Marburg. Boldyreva has investigated solid pharmaceutical compounds and biomimetic molecules. She also worked at Durham University as a Royal Society Fellow.
She uses high pressure measurements to investigate and control the inter- and intra-molecular interactions in crystals. She has shown you can use pressure to induce new crystalline forms, as well as interrogating chemical reactions. Alongside experimental science, Boldyreva works on Monte Carlo simulations for solid-state reactions.
She serves on the advisory council of the Russian Ministry of Education and Science.
She is an editor for Acta Crystallographica, International Union of Crystallography Research Journal, CrystEngComm Journal of Thermal Analysis and Calorimetry and Pharmalogica.