Caliche is used in construction worldwide. Its reserves in the Llano Estacado in Texas can be used in the manufacture of Portland cement; the caliche meets the chemical composition requirements and has been used as a principal raw material in Portland cement production. 
The Great House at Casa Grande Ruins National Monument, Arizona, US, was built with walls of caliche. Caliche was also used in mortars used in of the Mayan buildings in the Yucatán Peninsula in Mexico. A dormitory in Ingram, Texas, and a demonstration building in Carrizo Springs, Texas, for the United States Department of Energy were also built using caliche as part of studies by the Center for Maximum Potential Building Systems.
In many areas, caliche is also used for road construction, either as a surfacing material, or more commonly, as base material. It is one of the most common road materials used in Southern Africa. Caliche is widely used as a base material when it is locally available and cheap. However, it does not hold up to moisture (rain), and is never used if a hard-rock base material, such as limestone, is available.