By the mid-1990s, Hazen felt that his research had reached a "respectable plateau" where the main principles of how crystals compress were known. The questions he was asking were increasingly narrow and the answers rarely surprising. So he changed research directions to study life's chemical origins. This opportunity came when a colleague at George Mason University, Harold Morowitz, realized that the temperature and pressure at a hydrothermal vent might change the properties of water, allowing chemical reactions that ordinarily require the help of an enzyme. Enlisting the help of Hatten Yoder, a specialist in high pressure mineralogy, they tried subjecting pyruvate in water to high pressure, hoping for a simple reaction that would return oxaloacetate. Instead, an analysis by an organic geochemist, George Cody, found that they obtained tens of thousands of molecules.
The publication of their results, which seemed to support the deep sea vent hypothesis, met with heavy criticism, especially from Stanley Miller and colleagues who believe that life emerged on the surface. Along with the general criticism that organic compounds would not survive long in hot, high pressure conditions, they pointed out several flaws in the experiment. In his book, Genesis, Hazen acknowledges that Stanley Miller "was basically right" about the experiments, but argues that "the art of science isn't necessarily to avoid mistakes; rather, progress is often made by making mistakes as fast as possible, while avoiding making the same mistake twice." In subsequent work, the group formed biomolecules from carbon dioxide and water and catalyzed the formation of amino acids using oxides and sulfides of transition metals; and different transition elements catalyze different organic reactions.