Wüstite forms a solid solution with periclase (MgO), and iron substitutes for magnesium. Periclase, when hydrated, forms brucite (Mg(OH)), a common product of serpentinite metamorphic reactions.
Oxidation and hydration of wüstite forms goethite and limonite.
Zinc, aluminium, and other metals may substitute for iron in wüstite.
Wüstite in dolomite skarns may be related to siderite (iron(II) carbonate), wollastonite, enstatite, diopside, and magnesite.