Uterine leiomyomas are the most common tumors found in the female genital tract.  Leiomyomas have been reported to grow under the influence of ovarian steroids (estrogen and progesterone).  Aberrations of wnt signaling, as well as SFRPs, can contribute to the neoplastic process.  This led Fukuhara et al. to investigate whether SFRP1 is associated with the pathogenesis of uterine leiomyomas by analyzing mRNA and protein expression of SFRP1 in leiomyomas and matched normal myometrium. The following outlines their findings: