text: dOFM (Figure 4) allows the investigation of transport of drugs in the dermis and their penetration into the dermis after local, topical or systemic application, and dOFM is mentioned by the U.S. Food and Drug Administration as a new method for assessment of bioequivalence of topical drugs.
  dOFM is used for:
  * conduct tissue-specific pharmacokinetic (PK) and pharmacodynamic (PD) studies of drugs.
  * perform head-to-head comparison of novel topical drug formulations
  * assess dermal bioavailability.
  * investigate high molecular weight compounds, e.g. antibodies
  Head-to-head settings with OFM have proven particularly useful for the evaluation of topical generic products, which need to demonstrate bioequivalence to the reference listed drug product to obtain market approval.
  Applications of dOFM include ex vivo studies with tissue explants and preclinical and clinical in vivo studies.