text: Nanodomain signals are thought to improve the temporal precision of fast exocytosis of vesicles due to two specific properties:
  * The peak concentration of calcium ions will be reached incredibly quick (within a microsecond) and maintained as long as the channel is open.
  * Closure of the channel leads to a rapid collapse of the domain due to lateral diffusion away from the pore (the site of entry). The lateral diffusion of microdomains additionally depends on the action of fast endogenous buffers (which remove the calcium and transport it away from the active zone).
  Single channels are able to cause vesicular release, however, the cooperativity of different calcium channels is synapse-specific. The release driven by a single calcium ion channel minimizes the total calcium ion influx, overlapping domains can provide greater reliability and temporal fidelity.