text: Fibrin scaffold is an important element in tissue engineering approaches as a scaffold material. It is advantageous opposed to synthetic polymers and collagen gels when cost, inflammation, immune response, toxicity and cell adhesion are concerned. When there is a trauma in a body, cells at site start the cascade of blood clotting and fibrin is the first scaffold formed normally. To achieve in clinical use of a scaffold, fast and entire incorporation into host tissue is essential. Regeneration of the tissue and the degradation of the scaffold should be balanced in terms of rate, surface area and interaction so that ideal templating can be achieved. Fibrin satisfies many requirements of scaffold functions. Biomaterials made up of fibrin can attach many biological surfaces with high adhesion. Its biocompatibility comes from being not toxic, allergenic or inflammatory. By the help of fibrinolysis inhibitors or fiber cross-linkers, biodegradation can be managed. Fibrin can be provided from individuals to be treated many times so that gels from autologous fibrin have no undesired immunogenic reactions in addition to be reproducible. Inherently, structure and biochemistry of fibrin has an important role in wound healing. Although there are limitations due to diffusion, exceptional cellular growth and tissue development can be achieved. According to the application, fibrin scaffold characteristics can be adjustable by manipulating concentrations of components. Long-lasting durable fibrin hydrogels are enviable in many applications.