text: OFM comprises more than 24 collagens (most notably types I and III), but also contains many growth factors, polysaccharides and proteoglycans that naturally exist as part of the extracellular matrix and play important roles in wound healing and soft tissue repair. The composition includes more than 150 different proteins, including elastin, fibronectin, glycosaminoglycans, basement membrane components, and various growth factors, such as vascular endothelial growth factor (VEGF), fibroblast growth factor (FGF) and platelet derived growth factor (PDGF). OFM has been shown to recruit mesenchymal stem cells, stimulate cell proliferation, angiogenesis and vascularogenesis, and modulate matrix metalloproteinase and neutrophil elastase. The porous structure of OFM has been characterized by differential scanning calorimetry (DSC), scanning electron microscopy (SEM), atomic force microscopy (AFM), histology, Sirius Red staining, small-angle x-ray scattering  (SAXS), and micro computerized topography (MicroCT). OFM has been shown to contain residual vascular channels that facilitate blood vessel formation through angioconduction.