text: Human skin is a very impermeable membrane that protects the body from ingress of harmful substances and prevents water loss from underlying organs. However, this seriously limits the use of skin as a site for drug administration. One of the approaches to facilitate transdermal drug delivery is the use of penetration enhancers. Many different compounds have been explored as potential penetration enhancers to facilitate transdermal drug delivery. These include dimethylsulphoxide, azones (such as laurocapram), pyrrolidones (for example 2-pyrrolidone), alcohols (ethanol and decanol), glycols (for example propylene glycol), surfactants, urea, various hydrocarbons and terpenes. Different potential skin site and modes of action were identified for penetration enhancement through the skin. In some cases, penetration enhancers may disrupt the packing motif of the intercellular lipid matrix or keratin domains. In other cases, drug penetration to the skin is facilitated because the penetration enhancer saturates the tissue and becomes a better system to dissolve the molecules of API.