text: The affinity of the ASGPR-ASGP interaction is dependent on factors including the number of sugars present on the ASGP. For example, ASGPs with a one galactose have a higher dissociation constant (i.e., a lower affinity interaction) compared an ASGP with several sugars attached. This increased affinity in the presence of more sugars is likely due to the formation of more interactions between the carbohydrate recognition domain of the ASGPR and the sugars on the ASGP. The affinity of the interaction is also mediated by the modifications of the terminal galactose; for example, ASGPs with N-acetylgalactosamine have a higher affinity interaction for the ASGPR compared to ASGPs with a galactose.