text: Ernest L. Eliel has proposed that the hypothetical reaction of cyclohexyl iodide with radiolabeled iodide would result in a completely symmetric transition state. Because both the equatorial and axial-substituted conformers would react through the same transition state, ΔΔG would equal zero. By the Curtin–Hammett principle, the distribution of products should then be 50% axial substituted and 50% equatorial substituted. However, equilibration of the products precludes observation of this phenomenon.