text: F has a nuclear spin (I) of  and a high gyromagnetic ratio.  Consequently, this isotope is highly responsive to NMR measurements.  Furthermore, F comprises 100% of naturally occurring fluorine. The only other highly sensitive spin  NMR-active nuclei that are monoisotopic (or nearly so) are H and P.  Indeed, the F nucleus is the third most receptive NMR nucleus, after the H nucleus and H nucleus.
  The F NMR chemical shifts span a range of ca. 800 ppm.  For organofluorine compounds the range is narrower, being ca. -50 to -70 ppm (for CF groups) to -200 to -220 ppm (for CHF groups). The very wide spectral range can cause problems in recording spectra, such as poor data resolution and inaccurate integration.
  It is also possible to record decoupled F{H} and H{F} spectra and multiple bond correlations F-C HMBC and through space HOESY spectra.