text: LSD made a comeback in the 1980s accompanying the advent of recreational MDMA use, first in the punk and gothic subcultures through dance clubs, then in the 1990s through the acid house scene and rave subculture. LSD use and availability declined sharply following a raid of a large scale LSD lab in 2000 (see LSD in the United States). The lab was run by William Leonard Pickard (who served 17 years of a two lifetime sentence in US federal prison in Tucson, AZ) and Clyde Apperson (now serving 30 years in prison). Gordon Todd Skinner, who owned the property the large scale lab had been operating on, came to the DEA looking to work as an informant. He and his then-girlfriend Krystle Cole were intimately involved in the case, but were not charged in the bust. The lab was allegedly producing a kilogram of LSD every five weeks, and the U.S. government contends that LSD supply dropped by 90% following the bust. In the decade after the bust, LSD availability and use has gradually risen. Since the late 1980s, there has also been a revival of hallucinogen research more broadly, which, in recent years, has included preclinical and clinical studies involving LSD and other compounds such as members of the 2C family compounds and psilocybin. In particular, a study released in 2012 highlighted the extraordinary effectiveness of LSD in treating alcoholism.
  In November 2015, Rolling Stone magazine reported on an increasing number of young professionals, particularly in the San Francisco area, who were using "microdosing" (around 10 micrograms) of LSD in an effort to "work through technical problems and become more innovative." In 2018, the book How to Change Your Mind: What the New Science of Psychedelics Teaches Us About Consciousness, Dying, Addiction, Depression, and Transcendence by Michael Pollan became a No. 1 New York Times best-seller, and How to Change Your Mind, a four-part documentary film adaptation of the book, was released in 2022. In 2020, Oregon became the first U.S. state to decriminalize possession of small amounts of LSD.