text: Not much is known about the mechanism of action of cyclamin. However, a study proposed possible mechanisms of action based on their experimental results. Firstly, cyclamin might activate the proteins caspase-3, caspase-8 and caspase-9. Caspases are proteins that can induce apoptosis when being activated.
  Secondly, cyclamin could be responsible for increasing the expression levels of the cyclin-dependent kinase 2 and the cell division cycle 25 homolog A. This can lead to increased DNA synthesis and cell proliferation and an increase in signal transduction pathways.
  Thirdly, cyclamin could increase the ratio of Bax/B-cell lymphoma 2 expression. This would favour apoptosis to take place.
  Another property that was found is that cyclamin increases the permeability of Bel-7402 cells. This might be the reason why cyclamin enhances the effect of some chemotherapeutical drugs.