text: Anandamide's effects can occur in either the central or peripheral nervous system. These distinct effects are mediated primarily by CB cannabinoid receptors in the central nervous system, and CB cannabinoid receptors in the periphery. The latter are mainly involved in functions of the immune system. Cannabinoid receptors were originally discovered as being sensitive to Δ-tetrahydrocannabinol (Δ-THC, commonly called THC), which is the primary psychoactive cannabinoid found in cannabis. The discovery of anandamide came from research into CB and CB, as it was inevitable that a naturally occurring (endogenous) chemical would be found to affect these receptors.
  Anandamide is also important for the implantation of the early stage embryo in its blastocyst form into the uterus. Therefore, cannabinoids such as Δ-THC might influence processes during the earliest stages of human pregnancy. Peak plasma anandamide occurs at ovulation and positively correlates with peak estradiol and gonadotrophin levels, suggesting that these may be involved in the regulation of anandamide levels. Subsequently, anandamide has been proposed as a biomarker of infertility, but so far lacks any predictive values in order to be used clinically.
  The acute beneficial effects of exercise (termed as runners high) seem to be mediated by anandamide in mice. Anandamide is the precursor of a class of physiologically active substances, the prostamides. Anandamide was found in 2007 to inhibit the proliferation of certain human breast cancer cell lines in vitro'.
  Anandamide is found in chocolate together with two substances that might mimic the effects of anandamide, N-oleoylethanolamine and N-linoleoylethanolamine.
  Additionally, anandamide and other endocannabinoids are found in the model organism Drosophila melanogaster (fruit fly), although no CB receptors have been found in any insects.