text: Microscale chemistry (often referred to as small-scale chemistry, in German: Chemie im Mikromaßstab) is an analytical method and also a teaching method widely used at school and at university levels, working with small quantities of chemical substances. While much of traditional chemistry teaching centers on multi-gramme preparations, milligrammes of substances are sufficient for microscale chemistry. In universities, modern and expensive lab glassware is used and modern methods for detection and characterization of the produced substances are very common. In schools and in many countries of the Southern hemisphere, small-scale working takes place with low-cost and even no-cost material. There has always been a place for small-scale working in qualitative analysis, but the new developments can encompass much of chemistry a student is likely to meet.