text: Synthetic wastewater was used in most of the works carried out with aerobic granules. These works were mainly focused on the study of granules formation, stability and nutrient removal efficiencies under different operational conditions and their potential use to remove toxic compounds. The potential of this technology to treat industrial wastewater is under study, some of the results:
  *  Arrojo et al. (2004) operated two reactors that were fed with industrial wastewater produced in a laboratory for analysis of dairy products (Total COD : 1500–3000 mg/L; soluble COD: 300–1500 mg/L; total nitrogen: 50–200 mg/L). These authors applied organic and nitrogen loading rates up to 7 g COD/(L·d) and 0.7 g N/(L·d) obtaining removal efficiencies of 80%.
  * Schwarzenbeck et al. (2004)   treated malting wastewater which had a high content of particulate organic matter (0.9 g TSS/L). They found that particles with average diameters lower than 25–50 μm were removed at 80% efficiency, whereas particles bigger than 50 μm were only removed at 40% efficiency. These authors observed that the ability of aerobic granular sludge to remove particulate organic matter from the wastewaters was due to both incorporation into the biofilm matrix and metabolic activity of protozoa population covering the surface of the granules.
  * Cassidy and Belia (2005)   obtained removal efficiencies for COD and P of 98% and for N and VSS over 97% operating a granular reactor fed with slaughterhouse wastewater (Total COD: 7685 mg/L; soluble COD: 5163 mg/L; TKN: 1057 mg/L and VSS: 1520 mg/L). To obtain these high removal percentages, they operated the reactor at a DO saturation level of 40%, which is the optimal value predicted by Beun et al. (2001) for N removal, and with an anaerobic feeding period which helped to maintain the stability of the granules when the DO concentration was limited.
  * Inizan et al. (2005)   treated industrial wastewaters from pharmaceutical industry and observed that the suspended solids in the inlet wastewater were not removed in the reactor.
  * Tsuneda et al. (2006), when treating wastewater from metal-refinery process (1.0–1.5 g NH-N/L and up to 22 g/L of sodium sulphate), removed a nitrogen loading rate of 1.0 kg-N/m·d with an efficiency of 95% in a system containing autotrophic granules.
  * Usmani et al. (2008) high superficial air velocity, a relatively short settling time of 5–30 min, a high ratio of height to diameter (H/D=20) of the reactor and optimum organic load  facilitates the cultivation of  regular compact and circular granules.
  * Figueroa et al. (2008), treated wastewater from a fish canning industry. Applied OLR  were up to 1.72 kg COD/(m·d) with fully organic matter depletion. Ammonia nitrogen was removed via nitrification-denitrification up to 40% when nitrogen loading rates were of 0.18 kg N/(m·d). The formation of mature aerobic granules occurred after 75 days of operation with 3.4 mm of diameter, SVI of 30 mL/g VSS and density around 60 g VSS/L-granule
  *Farooqi et al. (2008), Wastewaters from fossil fuel refining, pharmaceuticals, and pesticides are the main sources of phenolic compounds. Those with more complex structures are often more toxic than the simple phenol. This study was aimed at assessing the efficacy of granular sludge in UASB and SBR for the treatment of mixtures of phenolics compounds. The results indicates that anaerobic treatment by UASB and aerobic treatment by SBR can be successfully used for phenol/cresol mixture, representative of major substrates in chemical and petrochemical wastewater and the results shows proper acclimatization period is essential for the degradation of m – cresol and phenol. Moreover, SBR was found as a better alternative than UASB reactor as it is more efficient and higher concentration of m cresols can be successfully degraded.
  *López-Palau et al. (2009), treated wastewater from a winery industry. The formation of granules was performed using a synthetic substrate and after 120 days of operation, synthetic media was replaced by real winery wastewater, with a COD loading of 6 kg COD/(m·d).
  *Dobbeleers "et al." (2017), treated wastewater from potato industry. Granulation was successful achieved and simultaneous nitrification/denitrification was possible by short cutting the nitrogen cycle.
  *Caluwé "et al." (2017), Compared an aerobic feast/famine strategy and an anaerobic feast, aerobic famine strategy for the formation of aerobic granular sludge during the treatment of industrial petrochemical wastewater. Both strategies were successful.