text: The most common adverse effects are diarrhea (4.8%), nausea and vomiting (3.6%), injection-site inflammation (2.4%), headache (2.3%), rash (1.9%) and thrombophlebitis (0.9%). Many of these adverse effects were observed in severely ill individuals already taking many medications including vancomycin.  Meropenem has a reduced potential for seizures in comparison with imipenem. Several cases of severe hypokalemia have been reported.