text: As mentioned in the introduction, two major limitations of the predecessor methods are not inherited by EPIC-Seq: germline or somatic variant dependency of common liquid biopsy methods which is also not certain to be found even in high-disease burden patients and methods like shallow WGS's insufficient range of cfDNA tissue consideration, genomic breadth and genomic depth which causes low-resolution and level of inference of gene expression and, again, requires high tumour burden for higher resolution. EPIC-seq uses fragmentomic features instead of variant calling, thus it is not bound by the existence of the variation. Also, since it does targeted sequencing instead of whole genome, it allows scientists to increase the sequencing depth and hence provide a better resolution. Moreover, it also provides more sensitive and comprehensive tissue-of-origin information.