Based on the previous sections, it is clear that the improvement workflow could locate more stable clusters. As the potential energy surface of multi-acid-multi-base clusters becomes very complicated, here we test this new approach for such systems. These 288 new AMcontaining clusters were used as a massive test set for the improvement workflow using the newly parameterized AMC-xTB model. The improvement workflow manages to find configurations lower in free energy at the ωB97X-D/6-31++G(d,p) for 245 out of the 288 clusters (85.1 %) as can be seen in Figure . In most cases, the improvement is between 0-2 kcal/mol. However, for the (SA) 1 (MSA) 1 (NA) 1 (FA) 1 (AM) 1 (DMA) 2 (TMA) 1 , (SA) 3 (NA) 1 (AM) 1 (MA) 3 , and (SA) 3 (FA) 1 (AM) 1 (MA) 1 (DMA) 2 clusters a massive improvement of 8.3, 5.2 and 3.9 kcal/mol is observed, respectively.