The electrostatic effect for DS -adsorbing to the AWI is shown in Fig. . Interestingly, the free energy and both the energetic and entropic components are all nearly 0 up to 0.5 nm from the GDI. Beyond this point, the electrostatic energy component, ∆ el E el,W , becomes repulsive due to water desolvation. The large differences between the electrostatic component and the total solute-solvent energy, ∆ el E vw⊕el,W (z), shows that when the solute is pulled beyond the GDI, the attractive LJ interactions are enhanced as a result of turning on the DS -partial charges. This effect is likely a result of DS -attracting water molecules out of the AWI with the charged head group. These differences are possibly also due to orientational effects since DS -keeps its head group pointed toward the water as it is pulled into the gas phase, while DS 0 has no such preference since the head and tail have similar LJ interactions.