Previously we have introduced a multicopy molecular dynamics method for enhanced conformational sampling, based on the coupling of a swarm of simulation replicas via attractive and repulsive pair potentials acting on dihedral angles of interest. Specifically this potential is a function of the root-mean-square (RMS) dihedral angle distance over all K dihedrals j between swarm replicas α and β, ie. (𝑀 -1 ∑ (𝜑 𝑗 𝛼 -𝜑 𝑗 𝛽 ) 2 𝐾 𝑗 ) 1/2 . Here we introduce a variant of this swarm methodology, which we term the multi-dimensional swarm enhanced sampling method (msesMD). This approach decomposes the biasing swarm potential 𝑈 𝑠𝑒𝑠 into a series of sub-swarm energy terms: