However, most LP-TEM studies solely rely on an incomplete description of the chemical environment, ignoring the intra-and interplay of complete clusters of chemical species. For example, investigations of gold nanoparticle evolution in aqueous tetrachloroauric acid (HAuCl4) solution, one of the most frequently used model systems in LP-TEM, mainly rely on the radiochemistry of pure (and partially even deaerated) water. More accurate descriptions are sparse and only describe gold precursor reduction or the radical chemistry of aqueous chloride solutions. In this study, we introduce a novel approach to translate chemical reaction sets into kinetic models, drastically simplifying and therefore allowing for a completion of the accurate description of the complex solution chemistry during LP-TEM. We demonstrate the full potential of this approach by providing a comprehensive description of the radiochemistry of aqueous HAuCl4 solutions, unveiling that the interplay between aqueous, gold-, and chlorinecontaining species is crucial for an appropriate description of the solution chemistry. By using LP-TEM and liquid cell X-ray diffraction (XRD), we show that it is essential to consider the impact of ionizing radiation even for experiments with 'low dose rate' irradiation techniques. Furthermore, we reveal how the initial HAuCl4 concentration determines the redox-interplay during LP-TEM and probe the impact on the Gibbs free energy landscape by investigating the inherent stability of gold nanoparticles in oxidative environments.