Considering the dual nature of CSHNs, the synthesis of liposomes and polymeric particles in two independent steps followed by their integration was the most reasonable approach for the preparation of CSHNs. As advantageous as this method was initially, it proved to be disadvantageous over time, as it introduced certain limitations and problems that only later came to light. First, since this manufacturing method consists of three consecutive steps, the entire process is very time-consuming. Moreover, this synthetic method requires energy, which necessitates the use of ultrasound, vortex, extrusion, or probe sonication.