The molecules were evolved in the genetic algorithm Ligand GA software by using the SARS-Cov-2 Mpro binding site. In addition, the molecules were post-processed on a primary liver human enzyme CYP 3A4. The same extensive GOLD parameters were used on both proteins for all molecules, and a 20 Angstrom sphere cavity file was used with the sphere centered on the Mpro GLU amide and the CYP 3A4 heme iron.