An interesting observation about the computed VAMP-2 scores is the large variation in their numerical value across the nine force fields (Figure ). CHARMM36 and AMBER14SB have the lowest and highest average VAMP-2 scores, respectively. For AMBER14SB, our results suggest this is due rare formation of the 2:2 turn, contributing slow relaxation timescales to the overall dynamics. For CHARMM36, we speculate that the low folded state population and negligible misfolded population leads to accelerated kinetic timescales compared to other force fields.