Dimeric presentations of Man79 (PM68 and PM70) and Man84 (PM69 and PM74) were prepared using a rod-like divalent scaffold, Rod3 36 (Scheme 3), that we previously employed for the synthesis of multivalent DC-SIGN ligands . We were able to show that this rod-like core has the appropriate size to bridge adjacent sites in DC-SIGN tetramers . Since the distance between L-SIGN sugar binding sites is reportedly longer (Fig. ), two PEG linkers of different lengths were adopted in the design of the dimers. The monovalent spearheads were installed using CuAAC ligation, so the azides 8 and 9