This implementation of physics-informed HPPC significantly enhances the quality of information gathered compared to industry-standard HPPC experiments. The method demonstrates an asymmetric sensitivity of information to degradation parameters between charge and discharge from differing scales of cell kinetics. It enables us to discern the physical roots behind degradation symptoms more accurately and efficiently. The impact of different states of charge and voltages on probing distinct degradation mechanisms is also explored . Our investigations also shed light on the limitations of HPPC experiments, specifically the fact that degradation mechanisms at the overpotential dominant electrode (the electrode where the overpotentials are larger than that at the opposing electrode) are extracted more easily than those at the non overpotential dominant electrode.