Here, we introduce two examples where IDPP-based path generation yields high-energy paths. The first example is reaction 93 from the reaction set in ref 13, which was reconstructed by Ásgeirsson et al. from the reaction sets created by Zimmerman and by Birkholz and Schlegel. In the present study, we refer to it as ZBA121, named after the first authors. Reaction 93 is the isomerization of peracetic acid catalyzed by cis-2-butene, where the OH at the tip of the hydroperoxy group is transferred to the other oxygen (Figures and). During this process, the orientation of the peracetic acid and butene also changes significantly.