Here, we utilized DFT calculation to study the catalytic activity and selectivity of ORR on Ni-loaded CrBr3 under applied potential. Specifically, three representative catalysts with different loading, Ni1/CrBr3, Ni2/CrBr3 and Ni8/CrBr3, show different magnetic properties from pristine CrBr3 support. Consequently, O2 adsorption properties (configuration, adsorption energy) on them cannot obey d-band center theory but relies on the magnetic anisotropy. Furthermore, the introduction of a metal bond coordinated directly to the active site weakens the adsorption of O2 on Ni site.