As part of the training of students and newcomers to the fields, we encourage them to do not necessarily seek the single-best approach to solve a specific problem or try to identify the "one-size-fits-all" (the methodology that will solve all problems as these might usually be complex, as typically happens in drug discovery). Throughout the survey, we have seen that combining methods in different areas such as molecular representation, virtual screening, SP(A)Rs, and chemical space analysis usually offers superior results as opposed to using only one methodology. In other words, the paradigm shift that we are experiencing in cheminformatics not only allows us to create new types of experimental approaches, but also offers us a systematized path to find new ways of using the methods already developed. A challenge and potential shortcoming is identifying the appropriate combination(s). Lastly, combinations of Chemoinformatics with other non-chemistry areas such as art, open up new avenues to generate novel disciplines. As such, we want to encourage combining chemistry with unusual and artistic fields out of simple curiosity and perhaps discover beauty and novel techniques along the way.