An immediately striking aspect of these plots is the spatial distribution of the substitution effects. Figure depicts that while the sites nearer to the active site tend to affect the reaction energies more, the relationship is only approximate. For catalyst A, each substitution site contributes significantly, although the position para to the active site does so more than the meta position. Similarly for catalyst C, the intermediate energies are most sensitive to substitutions that are not necessarily the nearest site on the catalyst, but instead the atoms that are in strongest resonance with the active site. This is especially apparent for catalyst C, where the two active sites are very sensitive to substitutions at each other's position.