Our initial aim was to screen for both crystallinity and yield. As already after the first generation we obtained a near perfect score on crystallinity, we could already rank our reaction conditions based on yield. We determined the yield by weighing the powder obtained divided by the amount of porphyrin ligand used in the synthesis, which gives a good indication of what the actual yield would be. Interestingly, a number of conditions gave excellent results, with a high yield and good crystallinity (Figures and). As the crystallinity and yield where sufficiently high and the surface area similar to what was obtained previously, there was no need for a 3 rd generation of experiments.