We start with a structure (PDB) file for the host-guest complex. We then prepare a force field parameter file specific to the complex. In this tutorial, we have taken the initiative to provide the parameter file for the receptor-ligand complex. We assume that the users have prior experience with force field files for receptor complexes. Let us begin with the hostguest.pdb and hostguest.parm7 files. Outline 2 shows the files we will require for the successful completion of the SEEKR2 tutorial on the host-guest complexes.