In this work, we have shown that by a simple chemically exfoliation protocol, MnPS 3 can be effectively delaminated into single layers without the requirement of a capping agent. This result represents the preparation of aqueous suspensions of large-area high-quality flakes, which permit a high accessibility to their surfaces. These features boost the reactivity of these flakes in catalytic applications and opens the possibility of a subsequent molecular functionalization that could give rise to the development of a plethora of multifunctional materials that can be explored in the next future. Concurrently, if it is required to preserve the stability of the flakes in suspension, the use of capping agents is mandatory. We have proved how PVP, as well as PEI, can successfully stabilize MnPS 3 flakes in solution for several days. IR spectroscopy points out a strong interaction between the organic and inorganic counterparts that is significantly larger for PEI than for PVP, probably due to the interactions established between the amino groups of the polymer and S atoms of MnPS 3 .