In this work a complete computational binding analysis is given of the small molecule treatment Paxlovid for early SARS-Cov-2 infection which is useful for a thorough understanding of the drug interactions. SARS-Cov-2 remains a continual threat to the population even after 2 years during which time its molecular structure and amino acid variations have been extensively documented . Although vaccines have been successfully developed and used, there still remains the development of a viable therapeutic that has no potential risk to the general individual. This is motivating in finding new small molecules, possibly unrelated to known molecules and without repurposing.