Although MAS is a powerful laboratory instrument for large-scale synthesis as well as for high-throughput explorations of the chemical and sequence space of nucleic acids, these devices are not commercially available, and their design is generally well beyond the skill set of nucleic acid chemists, molecular biologists, geneticists and other potential users. In addition, advances in DMDs, light sources and optical systems strongly encourage a new design taking advantage of all the technological advancements available since the original MAS ("MAS 1.0") design in the late 1990's.