The streamlined isolation protocol of 6 and 2 by filtration and washing with water has an additional advantage. Although the solvent-related and thermal hazards have been greatly attenuated in our approach, it still relies on the use of stoichiometric amide-coupling reagents (EDC and TFFH), which themselves or their reaction products (e.g., tetramethyl urea, TMU), could pose environmental or health hazards, thus representing a disadvantage. On the other hand, TFFH is an air-stable and non-hygroscopic solid that offers a better safety profile than other amide couplers.