Fortunately, both aims are achievable by utilizing an environmentally responsible approach that relies on reactions run in Nature's "solvent": water. Such a "switch" 10 is made possible through aqueous micellar catalysis, which simply involves the presence of an appropriately engineered and readily available micelle-forming nonionic surfactant that promotes solubilization of typically water-insoluble substrates. 11 Furthermore, use of a common aqueous medium enables telescoping of reactions, thereby eliminating wasteful intermediate workups, while gaining in both time and pot economy. We now describe our recent efforts in collaboration with the Bill and Melinda Gates Foundation that have led to two inexpensive, scalable, and environmentally attractive routes to Pyronaridine.