An innovative strategy for gynaecological cancer treatment involves using sperm cells as drug microcarriers. Their adaptability to the reproductive tract, efficient drug loading, and ability to fuse with somatic cells make them promising candidates. Researchers have further engineered sperm-hybrid microrobots by developing 4D-printed microcarriers for transporting multiple motile sperm and locally degrading the cumulus complex surrounding the oocyte via hyaluronidase-loaded polymersomes (HYAL-Psomes). Building on this concept, in this work we present a microrobotic platform for potential cervical cancer therapy using sperm-hybrid microcarriers equipped with photo-crosslinked and pH-responsive polymeric vesicles (X-Psomes), each targeting distinct aspects of the tumour and its microenvironment. Two surface-active enzyme-loaded Psomes-Hyaluronidase (HYAL-Psomes) and matrix metalloproteinase-1 (MMP-1-Psomes)-were used for microcarrier functionalization. These Psomes provide an active surface for ECM interaction without premature enzyme release, ensuring controlled activity. To further enhance tumour targeting, the microcarrier is functionalized with drug-loaded Psomes containing a curcumin complex (CU(βCD)2), designed with a hydrophobic membrane to increase loading capacity and enable pH-sensitive release. In summary, this study aims to establish a multifunctional robotic platform to advance localized and targeted therapy to enhance treatment outcomes from a functional and structural point of view. To this end, the following key objectives have been addressed: (i) Selection of a wellestablished microcarrier featuring Ti/Fe and Au outer discrete multicoating for magnetic guidance and photoacoustic imaging applications. This microcarrier is chosen for its adaptability and biological activity, allowing for the decoration with specific therapeutic nanoreservoirs tailored to distinct therapeutic windows (e.g., controlled release of anti-tumor drugs and extracellular enzymatic therapeutics). Enhancement of the functionalization and versatility of the (biohybrid) microcarriers with various loaded Psomes, enabling diverse combined therapies within the same material. (iii) Comprehensive structural characterization utilizing advanced techniques, along with preliminary biological testing. Scheme 1. An illustration depicting a microcarrier decorated with dual-functionalized polymersomes aiming combined therapeutic effect for cancer therapy. The system features two specialized nanocompartments: Antitumoral nanoreservoir 1 -Releases a CU complex (CU(βCD)₂-Psomes) directly into the tumor via the pH-responsive permeability of polymersomes; Digestive nanoreservoir 2-Acts as a nanoreactor to degrade the extracellular matrix (ECM), enhancing drug penetration through MMPsomes and HYAL-Psomes. Two propulsion mechanisms can be used for this vision: A) magnetic guidance through an external magnetic field facilitated by a Ti/Fe coating layer, and B) motile sperm cells.