CarD-like (IPR052531) is a transcriptional regulator that is similar to CarD. Transcription factors in this protein family interact with RNA polymerase to regulate the transcription of ribosomal RNA. In certain organisms, members are involved in the regulation of replication and persistence during infection. They are also critical for maintaining rRNA levels under normal growth conditions and are involved in the response to a variety of stresses, such as malnutrition, oxidative, and genotoxic stress. DM (IPR001275): A conserved family of transcription factors encoded by DMRT genes shares a unique DNA-binding motif, the DM domain. The twosex protein of Drosophila melanogaster initially identified this domain. Alternatively spliced mRNAs that encode sex-specific polypeptides are produced by the twosex gene in Drosophila melanogaster, which regulates somatic sex differentiation. It is hypothesized that these proteins function as transcription factors for downstream sex-determining genes, with a particular emphasis on the transcription of the vitellin gene and neuroblast differentiation.