Instead, only 180° of the double bond rotation is accessible, which proceeds exclusively within the bottom half-space of the thioindigo plane (see also Figure for depiction of the half-space assignments). Because this back-and-forth rotation is coupled to thermal atropisomerizations in 1, symmetry is broken for the motions and directional 360° rotation is established around a new and shifted virtual axis. When comparing the two rotations in the separated HTI-motor component (directional double bond rotation) and corresponding macrocyclic 1 (directional rotation around virtual axis) a reversal of directionality is also observed. While the HTI-motor intrinsically rotates clockwise for the perspective chosen in Figures and macrocyclic motor 1 now rotates counterclockwise instead. The macrocyclization approach therefore enables a precise reprogramming of a molecular motors directional motions without resorting to changing the identity of the embedded motor structure itself. We believe that such approach will be of high interest when considering both, design as well as applications of molecular motors in the future.