The constant MD time approach cannot capture this effect, as it systematically overestimates the timescales of barrierless reactions. This unphysical allocation of MD time also increases the computational cost, as shown by inspecting the reactive cycle at which each successive nanosecond of total elapsed MD time occurs (gray dashed lines). At reactive cycle 315, where the variable approach reaches 1 ns of elapsed MD time, the constant approach has already elapsed ∼ 2.5 ns. By reactive cycle 650, the variable approach has elapsed 3.38 ns of MD time, 38% lower than the 5.47 ns elapsed by the constant approach.