To recapitulate, we encountered many different application areas for tough hydrogels, yet only selected examples achieved high impact through combination of careful experimental design and material analysis. The majority of studies in this review focus on the hydrogel's structure-property relationship, self-healing, and self-recovery behavior and as a logical continuation, the exploration of specific, targeted applications would be desirable. Among the applied studies, biomedical applications are by far the most popular choice, which include the direct use of gels as tissue engineering scaffolds (e.g., wound healing) as well as the fabrication of biomedical devices for (post-)operational use. Besides, opportunities of tough hydrogels in soft electronics, actuators or 3D printing are increasingly explored, which often however, represent just an intermediary step towards their final application in the biomedical field. Some reports ensure good correlation between mechanical properties of the gels and the tissue beforehand, while in other instances the assumption prevails that deviating or exceeding properties will still satisfy the needs of the targeted (tissue) application. This being said, matching the material's properties to the target environment is less prevalent in soft electronics or actuators, where the need for specific (fracture) mechanical properties are often not further explained. Nonetheless, a broad range of (fracture) mechanical properties has become accessible. Consequently, the question arises, whether this may open up new areas of applications, which will be subject of the final and last section of this review.