On the other hand, during screening selection based only in dockingscore rank evaluations, the candidates progressively increased in molecular weight and hydrophobicity, trending to select unspecific leads 40, 41 . Alternative parameters to improve ligand efficiency have been developed throughout the years such a Ligand Efficiency (LE), Lipophilic Ligand Efficiency (LLE), Ligand Efficiency Lipophilic Prize (LELP) and many others . Therefore, corrections for the influence of molecular weight/hydrophobicity on ligands should be taken into account during the selection of candidates.