The images of chemical structures were depicted as grayscale 2D bitmap images using our open-source toolkit RanDepict . In the chemical literature, various types of chemical structure depictions are represented. This is due to the usage of numerous different software packages or even templates for hand-drawing chemical structures throughout different types of publications. RanDepict attempts to generate datasets in which all features that define different types of depictions are represented in a balanced and controlled manner by pseudo-randomly scrambling all available depiction parameters for every created image. Additionally, a variety of image augmentations like rotation, shearing, the addition of curved arrows in a structure, and the addition of text labels and reaction arrows around the structure can be applied .