The integration of Freeze Drying with High-pressure Homogenization significantly improves the solubility and the bioavailability of Curcumin, making it more effective for therapeutic applications. The stabilization provided by PVP and HPMC helps to extend the release profile of Curcumin with allows for prolonged therapeutic effect. However, the need for specialized equipment for High-Pressure Homogenization and Freeze-Drying may limit accessibility for some research institutes . Schematic diagram for preparation of curcumin nanoparticle by Freeze-Dried Anti-solvent Crystallization and High-Pressure Homogenizer Method is shown in figure .