Since clusterin protein is expressed in beta cells, its expression level could be correlated with the beta cell biomass. Increased clusterin expression in beta cells is related to beta cell oxidative stress and could eventually lead to Type 1 diabetes. Since the clusterin protein is released into the bloodstream, it is easy to measure its plasma level, which could indicate the beta cell mass or cell stress level. Based on this theory, Simaeys' et al. recently designed an RNA-based aptamer targeting clusterin protein as a pre-diabetic biomarker . We hypothesize that the binding of aptamers should be due to their unique shape and sequence. Therefore, we have performed computational simulations to understand the aptamer-biomarker protein interactions. Specifically, we designed aptamers' 3D structures and later docked them on clusterin protein.