Inspired by the various reactions of the LTO of butane and cyclohexane, we have developed various CV templates to eciently explore the space of (LTO) reactions and studied the inuence of CV parameters on eectively found reaction types and CPU times. The corresponding templates are named with four letters: the rst two describe the elements of the atoms involved in the respective bond, followed by bb if bond breaking is accelerated and bf if bond formation is accelerated. Seven templates have been generated (and equally applied during the simulation setup) that make use of CVs with optimized parameter settings given in the SI: (1) chbb without switching function, (2) cobf, (3) cobf, cobf + ccbb, cobf + ccbf, (4) ccbb without switching function, (5) ccbb, (6) ccbf, ohbf. Template 3 contains three cases with the same weight of one third. To illustrate the major reaction classes addressed by the integrated templates, we use reactions from the cyclohexane 2-peroxy radical system as test case. We use eight representative key reactions from this network to study CV templates, listed in Table .