We demonstrated that the SDL presented here can be used for synthesizing various nano-and advanced materials with a large variety of synthesis chemistries, i.e., precursor reduction for the synthesis of AuNPs, sol-gel synthesis for silica NPs and MSN, coordination chemistry for the MOF ZIF-8, co-precipitation for CuO, and seed-mediated growth for Au@SiO2 and CuO@SiO2 coreshell nanoparticles. We further showed the fully automatic synthesis, purification, and in-line characterization of these materials with DLS and absorbance measurements.