Most of our knowledge regarding the protein targets of chloroacetanilides come from activity-based protein profiling (ABPP) experiments . In these experiments, protein targets of a small molecule are identified based on their covalent reaction with a probe. Direct experiments substitute the small molecule with an isolable tag to generate the probe, while competition experiments use a probe with defined reactivity (e.g. for pK-pertubed cysteines) and profile proteins that can be competed out by the small molecule. Mice injected with acetochlor accumulated cysteine adducts in fatty acid oxidation pathway proteins with consequent metabolic deficits . Broadly, most cysteines are not readily reactive to chloroacetamides, and even reactive cysteines show high specificity for individual ligands . While powerful, this approach is limited to identifying proteins that form direct adducts with the probe. Pesticides and herbicides can produce secondary metabolites associated with protein damage and destabilization 19-21 , leading to changes in protein stability , through mechanisms that should not change ABPP reactivity. More generally, loss of proteostasis for individual damaged proteins has the potential to destabilize the broader proteome .