While natural organic matter and Mn oxides are abundant and pivotal to contaminant fate , the catalytic role of organo-mineral associations (e.g., protein-Mn oxide) in glyphosate transformation remains underexplored. This study fills a critical gap, demonstrating the critical role of organo-mineral associations in the abiotic transformation of glyphosate and enable us to estimate glyphosate bioavailability and long-range transport in redox-sensitive environments. In this study, we demonstrated that in the presence of protein association or with increasing pH, both the transformation rate and capacity of glyphosate on BSA-Mn oxide associations diminish. Additionally, a shift in glyphosate's abiotic transformation pathways may occur due to changes in its inner-sphere configurations. We demonstrated that the formation of monodentate complexes via phosphonate groups enhances the favorability of the AMPA pathway leading to increased production of AMPA, a toxic by-product, particularly at BSA-birnessite interface.