The important templates that aligned with this 4409 amino acid residues of the whole genome of the SARS-CoV-2 virus isolate Wuhan-Hu-1were 2a5i of the PDB database which is a crystal structure of SARS coronavirus main peptidase inhibited by an Aza-Peptide epoxide in the space group C2 and 3e9s of the PDB database which is new class of papain-like protease/deubiquitinase which when combined with ligand GRL0617 acts as inhibitors blocking SARS virus replication . The model with template 2a5i of the PDB database shows that Aza-Peptide Epoxide (APE; kinact/Ki=1900(±400) M -1 s -1 ) which is a known anti SARS agent can be used to develop a molecular target with irreversible inhibitor properties. The protein ligand interaction analysis of the Novel Coronavirus C3 like peptidase and aza-peptide epoxide is shown in Fig. . The model with template 3e9s of the PDB database shows that the Coronavirus viral protein can have a ligand which is a papain-like protease (PLpro) that is known to be a potent inhibitor of viral replication in SARS .