2D interaction diagrams are also a valuable tool as they provide a simplified, yet informative, visualization of the interactions between a ligand and its protein target. These diagrams help quickly understand the key interactions that contribute to binding, such as hydrogen bonds, hydrophobic contacts, salt bridges, ππ, and ionic interactions. This type of diagrams simplify the visualization of complex 3D molecular interactions, making it easier to understand and analyze the interactions between ligands and proteins. This simplification is crucial for quickly assessing the nature and strength of these interactions without the need to manipulate 3D structures. They allow for the comparative visualization of multiple ligand-protein complexes, particularly useful in drug discovery projects where multiple ligands are being assessed for their interaction with the same protein. 2D interaction diagrams are available from tools like PLIP , LigPlot+ , LeView , PoseEdit among many others.