In the following, we will introduce the physical concepts underlying each term in Eq. ( ) by starting with the binary case and extending it to the ternary one. However, due to the asymmetric nature of cooperativity, binary complexation between A and B is always used as an example in the following context to elucidate the physical meaning of each contribution of ∆G φ . Example of negligible cooperative solvation contribution in the ternary complex without a three-body interface.