Pathak aimed at the identification of small-molecule protein-protein inhibitors based on a pharmacophore mapping-based approach. For that, they used information about the hot-spot residues and their corresponding pharmacophoric features on the protein-protein interaction interfaces in the TLR4/MD2 homodimer complex. The authors performed extensive post-VS filtration (based on ADME/T properties, oral bioavailability, and possible side effects -offtargeting and environmental hazard) to propose novel small-molecule inhibitors. From selected hits, two (C11 and C15) with the predicted best inhibitory concentration were confirmed to form a stable complex with the target protein. In other studies, Facchini et al. and Cochet et al. focused on designing the monosaccharide mimetics of lipid A, which is a known agonist.