Second, we examined the alchemical transformation of ethane to ethanol. This particular transformation has been extensively studied in the context of free energy calculations, making it a relevant and valuable choice for our analysis. Furthermore, the change in polarity from hydrophobic ethane to hydrophilic ethanol provides an interesting test case. Our hypothesis centers on the impact of Hydrogen Mass Repartitioning (HMR). Specifically, HMR alters the atomic masses, decreasing the mass of oxygen from 16 amu to 13.984 amu and increasing the mass of hydrogen from 1.008 amu to 3.024 amu. We anticipate that these mass changes may influence the interaction of the transforming molecule with surrounding water molecules, thus affecting the calculated free energies.