Visual presentations like these often highlight specific docking solutions, but my concern is that, despite their visual appeal, it is difficult to determine whether the conformation facilitating such hydrogen bond networks in the active site has 0.1 kcal/mol, 1 kcal/mol, 10 kcal/mol of conformational strain energy, or somewhere in between. This uncertainty regarding ligand conformation can often be a critical factor, especially when the estimated protein-ligand interaction energies across the entire hit list vary by only 1 or a few kcal/mol. However, in this case, we know that the conformation used is the lowest-energy QM conformation available for this molecule in our database. This knowledge eliminates at least one significant source of uncertainty in the docking results, highlighting the advantage that QFVina and QFVinardo docking methods offer.