Within the automated synthetic screen, the self-assembly process was conducted at a 4:12:4 equivalence between the triamine, aldehyde and metal salt building blocks. The precursor library contained two tritopic triamines (A and B) and four aldehydes with varying methylation on the pyridyl ring (1-4), leading to 8 potential tritopic imine ligands, named based on their precursor components (L = A1, A2, A3, A4, B1, B2, B3, B4), and three metal salts with varying counterions: Zn(NTf2)2, Zn(OTf)2 and Zn(BF4)2 (Figure ). The reaction stoichiometry was selected to specifically target a M4L4 tetrahedron, however, other self-assembled products may form including M12L12 icosahedra and helicate structures formed from a ligand (L) linker and/or an intermediate (I) ditopic linker (formed by a two-fold partial imine condensation between the triamine and aldehyde precursors): M2I3, M2I2L, M2IL2 and M2L3 (Figure ).