There are two steps involved in the development of thermoplastic microfluidic platforms: device fabrication and channel functionalization -the latter of which we have extensively reviewed in a recent review paper . In this review, we provide a comprehensive overview of recent developments in the thermoplastic device fabrication space. More specifically, we first provide a thorough account of the instrumentation and approaches that can be engaged to form microchannel networks within thermoplastic polymer substrates. We subsequently detail the different approaches for bonding these microchannels, with consideration towards channel functionalization, which often occurs in parallel.