• Intervention, 'Methylphenidate', for Neurological disorders, has been used widely and seen in multiple trials such as 'NCT01244269', 'NCT02638168', 'NCT01825577', 'NCT00852059'. We notice that when all these records are in the test set, the performance was around 0.39 (mean ACC) and 0.75 (mean F1-Fail) whereas, if we have one trial in the test set and rest in the training set with other interventions, we obtain 1.0 for ACC and F1-Fail. • Intervention, 'Metoprolol', for cardiovascular diseases, is seen in trials such as 'NCT00806390', 'NCT00182039', 'NCT03371823'. We notice that the test set with all the trials associated with this intervention resulted in 0.65 (mean ACC) and 0.23 (mean F1-Fail) whereas when one trial of this intervention is in the test set, we obtain 1.0 for both ACC and F1-Fail. These observations lend credence to the hypothesis that the Leave-p-out scheme shows improved performance in predicting the failure rate when the training set is exposed to instances of the intervention applied to similar or other conditions (diseases) or targets.