The radiofluorination followed an adapted protocol developed by Hoffmann et coworkers. Radioligand [ 18 F]12 was synthesized in an average total synthesis time of 65 minutes via nucleophilic aromatic fluorination of borpinacol ester precursor 45 (Figure ). Starting from a [ 18 F]F -activity of 1.1-5.5 GBq, the radiotracer [ 18 F]12 was obtained with an activity yield (AY) of 0.16-1.05 GBq. Based on the amount of [ 18 F]F -trapped on the QMA cartridge, the radiochemical yield (RCY) was 21 ± 9% (n = 15) with a radiochemical purity (RCP) of >99% and a molar activity (Am) of 36 ± 24 GBq/µmol (n = 12). Representing chromatograms for the semi-preparative HPLC purification are shown in the supporting information (Figures ). Tracer identity was confirmed by co-injection of [ 18 F]12 with cold reference compound 12 (Figure ).