However, it poses a problem of nomenclaturehow can something be simultaneously co-conformationally chiral and topologically chiral? In short, it cannot but, given that the ensemble of covalent subcomponents displays the same symmetry properties as the previously named topologically chiral stereogenic unit of catenanes once the fixed co-conformation is considered, it is hard to see what else to call it. Chiral mechanically interlocked molecules are attracting increasing attention for applications in catalysis, including examples that depend solely on mechanical stereochemistry, 29 sensing 30 and as chiroptical switches. Furthermore, given the similarity between the co-conformational topological stereogenic unit and the co-conformational mechanical planar stereogenic unit in rotaxanes, it seems likely that this new class of chiral catenanes have the potential to act as the basis for stereodynamic switches. Finally, by highlighting the potential for interlocked molecules to display molecular chirality due to unexplored and even unsuspected stereogenic units, we hope to inspire further investigation of their rich stereochemistry.