The workflow of the modified parametrization approach is illustrated in Figure . This procedure has been implemented into a Python tool, which is available on Zenodo 59 .Using this tool, topology files obtained from the VSOMM2 can be directly converted into those for the coarse-grained structures, using a parametrization step. As a result, there is no need to perform or prepare reference simulations, as the parameterization can be carried out via a single command from the user.