Simultaneously, the transport function of the ABC transporter for drugs increased bacteria resistance and made antibiotics and other drugs ineffective. At present, COVID-19 patients in some areas had a dual infection of fungus and bacteria in their lungs. Long-term antibiotics for these patients increased bacterial resistance. For cells infected with the SARS-COV-2 virus, similar drug resistance problems would also arise because of the ABC transport function of ORF7a protein. Therefore, some researchers speculated from the statistical data that sickle cell infected SARS-COV-2 showed resistance but are very confused about it.