Alternatively, it is possible to derive a more reliable value for ∆H sub,298K from the measured solid solubilities across a range of temperatures. The dissolution enthalpy at 298K (∆H diss,298K ) can be estimated from the temperature gradient of the experimental solid solubility data near 298K using Eq. 8 and ∆H sub,298K can be subsequently estimated using Eq. 9 based on the estimated ∆H diss,298K and the predicted ∆H solv,298K . New predictions are made based on this approach for the solute/solvent pairs whose temperature gradient at 298K could be approximated from the experimental data. The resulting plots can be found in the supporting information (Figure ). As can be seen, substantial improvements are made using this approach for several pairs such as budesonide in water, 4-formylbenzoic acid in 1-methyl-2-pyrrolidinone, paracetamol in water, and propazine in water. However, solid solubility data sometimes have high experimental uncertainties and accurate measurements are needed to correctly estimate the temperature gradient. Moreover, if the main source of error is the ∆H solv,T term, this approach will not be able to improve the predictions at high temperatures.