Hantavirus is a rodent-borne disease. Hantavirus infection is related to hemorrhagic fever with renal syndrome (HFRS) and Hantavirus pulmonary syndrome (HPS) . In both of these disorders, increased vascular permeability is a common symptom. Hypotension, thrombocytopenia, and leukocytosis can occur. It affairs is a dearth of knowledge about Hantavirus pathophysiology and the molecular mechanism of virus replication.