To treat infected skin tissues, vancomycin is administrated intravenously in high doses to achieve effective results. The high doses often lead to challenges such as kidney failure, local pain, thrombophlebitis, and even anaphylaxis or erythema; all the while potentially contributing to resistance development. Therefore, delivering vancomycin topically can be an alternative option to overcome those challenges. The release profiles of vancomycin-loaded hydrogels were plotted for the different reductive media and the control medium and were observed to show a controlled trend (Figure ). The spontaneous release for different gel concentrations (i.e. different mesh sizes) was also tested and found negligible between a concentration of 8% and 17.5%. (Figure ).