We discovered domain annotations for PTEN-related by scanning the Interpro database. Tensin phosphatase contains two adjacent domains: one encoding a lipid phosphatase (PS51181) and another encoding a C2-like domain (Interpro ID: IPR014020). The structure of the type C2 domain in Tensin is comparable to that of the classic C2 domain. The tensin type C2 domain is similar to the PKC type C2 domain in that it lacks two of the three conserved loops that bind Ca2+. Tensin C2 type domain can attach to the phospholipid membrane in a Ca2+-independent manner. The lipid phosphatase domain dephosphorylates the D3 location of the inositol ring of the lipid's second messenger, phosphodiinositol-3-4-5-triphosphate (PIP3). In the active protein tyrosine phosphatase (PTP) and dual specific phosphatase, the lipid phosphatase domain comprises the distinctive pattern HCXXGXXR (DSP). Only two consistent lysines were discovered in the Tensin-type phosphatase motif (HCKXGKXR) Acid. These are suspected of interacting with the phosphate groups at the D1 and D5 locations of the inositol ring. Tensin, Kinase (linked to cytochrome G) and auxiliary protein 2, chromosome 10 protein (PTEN) are proteins that contain phosphatase and C2 tensin-type domains.