From the analysis of the features that are most relevant to ethane and ethylene adsorption, we can infer a few guiding principles that may help lead to producing more effective ethaneselective materials. Process conditions must be carefully considered and optimized during sorbent development to minimize ethylene adsorption since ethylene is very sensitive to process parameters while ethane is less so. Another consideration is in the design of the MOF SBU and linker. Linker topology is apparently much more relevant for ethane adsorption than ethylene, as evidenced by the high feature importance suggesting that appropriate linker design can lead to higher ethane uptake. Conversely, SBU complexity and electronegativity appear to be relevant to ethylene adsorption, suggesting that rational design of the binding motifs can be used to minimize ethylene uptake. (Bottom) Relative importance of the ten most important features, color-coded to match their subdivision. Note that a prime in a RAC indicates that it is a difference RAC. Geometric features are abbreviated as follows (Supporting Information Table ): ASA, accessible surface area; POAV, probe accessible volume; POAVF, probe accessible volume fraction; Di, diameter of largest included sphere; Df, diameter of largest free sphere.