 CDEV needs a proprietary research phase for patent generation that can extend for several years. When this is obviated by open research the development times can be considerably shortened  The team can garner varying levels of direct support (funded or voluntary) as well as crowdsourcing feedback from experts anywhere across the globe  They are free from the tyranny of having to pursue novel and broad composition-ofmatter chemistry for IP protection  This means they can fully exploit chemotypes with similarities in the expanding extant bioactive chemical space of at least ~ 5 million structures (although with the caveat of possible infringement issues)  Teams, host institutions and the community can reap the benefit of rapid, full and FAIR publications  ELNs can enable data surfacing in real time