The limitations of parameterizing intermolecular interactions based off of pure properties alone have been noted previously; given two molecules A and B, accurate prediction of A-A interactions and B-B interactions does not imply accurate prediction of A-B interactions. Simulated Δ measurements for A and B, calculated as in equation 1, can measure the cohesive energies of A-A and B-B systems, but are unlikely to capture A-B interactions unless A and B are very similar molecules. In equation 1, Δ refers to the difference in molar volume between the liquid and gas phases.