It was, however, difficult to draw general conclusions by piecing together all small-scale studies reviewed here. One reason is that almost each study is performed with a different source interface. Probing the outcome of the electrospray process in the mass analyzer is like trying to deduce the entire movie plot from just the last scene. Droplet size and desolvation history matter enormously because ions that traverse the harshest parts of the transfer interface while being protected by a solvent shell, which dissipates internal energy upon evaporation, will end up with less internal energy than those ejected "naked" early in the source.