The virtual screening performance of the MAPC fingerprint was evaluated in a comparative study with commonly used fingerprints (ECFP4, 37 ECFP6, Atom-Pair 29 ) in a benchmark adapted from Riniker and Landrum. Since the structure SMILES in the original benchmark do not contain any stereochemistry, the respective chiral SMILES (when applicable) were retrieved from the DUD, MUV and ChEMBL databases using the provided compound IDs.