To conduct this test, the guidelines prescribed by OECD (Organization for Economic Cooperation and Development guideline) were followed. The test doses used in the animal model have a limit dosage of 2000 mg/kg. Six groups fasted for 3-4 hours, those female albino mice having a weight of 20-25 g were taken into account for the test. Then, the crude extract of Rhodophyta was administered in the doses of 1000-1500 mg/kg. Finally, the control group of these mice was administered with a dose of 2000 mg/kg. These mice were deprived of water and food for further 1-2 h. For the next 24 hours, these mice were checked for toxicity, mortality or aberrant behavioral changes such as coma, diarrhea, sedation, convulsions, or abnormal eating habits or breathing, alertness, restlessness, and other motor responses were evaluated.