Furthermore, to prevent CO extrusion, the acyl radical formed during the reaction must be rapidly captured by a suitable olefin trap. To date, this reversibility has impeded radical carbonylation of volatile alkanes in any practical synthetic context. Given the challenges associated with the radical carbonylation of volatile alkanes, we anticipated that flow photoreactors could potentially overcome these limitations. Specifically, the use of back pressure regulators in combination with high light intensity can seamlessly increase the pressure and boost kinetics (𝑘 ∼ 𝐼, in which 𝑘 is the reaction rate, and 𝐼 the light intensity). As a result, and due to continuous nature of the technology, we were hopeful to realize for the first time a practical carbonylation of light alkanes at scales which were sufficient to isolate the target compounds. Interestingly, the reaction conditions developed for soluble hydrocarbons were successfully applied to n-butane with only a single modification: an extended residence time of 2 hours instead of 1 hour (Figure ). Using this protocol, n-butane was carbonylated and successfully coupled with a number of electron-deficient alkenes, including dimethyl maleate, crotonitrile, phenyl vinyl sulfone and vinyl phosphonate, in good isolated yields (26-29, 34-68%). With propane, similar yields were realized for the same set of Michael acceptors (30-33, 38-91%), reaching an impressive 91% for the reaction with dimethyl maleate, in a 3 h reaction time. The cleavage of stronger C-H bonds in ethane required a longer 4-hour residence time, but still yielded satisfactory results (34-37, 36-51%).