This mode is enabled by the flexibility of the AMOEBA 03 water model but is not compatible with rigid water models such as TIP3P commonly used with the CHARMM and AMBER force field. This framework allows to further reduce the computational cost gap between PFFs and nPFFs. This new mode, in addition to the other GaMD-dih and GaMDdual modes, is now available within the Tinker-HP software. In the following, we first tested its GPU scalability and performance on the STMV system (≃1 066 624 atoms), and its sampling efficiency is demonstrated on simulations of the alanine dipeptide and the CD2-CD58 complex. A technical appendix is present at the end of the manuscript and provides the formalism of the method and the associated debiasing equations.