Audry and coworkers introduced a scheme for molecular lipophilicity potential (MLP) to establish a three-dimensional representation of lipophilicity potential profile in the molecular environment ) and explored the impact of various substituents on the (V, L) maps. They also examined the characteristics of pyrazole derivatives, significant in medicinal chemistry for their role as inhibitors of liver alcohol dehydrogenase . The (V, L) maps provide a distinctive view of the 3D molecular surface, offering valuable insights into reactivity, solvent affinity, and the identification of crucial regions in molecular recognition and binding. Additionally, these maps can enhance drug-receptor matching for improved drug design. Du and Arteca studied lipophilicity of compounds featuring a hydrocarbon skeleton (R) and various hydrophilic functional groups (F). In 1996, they introduced four surface-MESP descriptors, namely BF + , BF -, BR + and BR -, which are employed for characterizing the lipophilic and hydrophilic properties of molecular fragments . The molecular lipophilicity (L) can be calculated based on these four parameters: