CYP isoforms 2C9 and 3A4 were chosen as models because they are key components in the reported metabolism routes of major cannabinoids . using 2C9 as shown in figure below, the green dots identify interactions with the 2C9 enzyme where possible oxidation may occur. While shown in figure , the oxidative sites predicted for the isoenzyme 3A4 are as shown. Further possible products of oxidation are shown in SI Figure and.