We explore the effect of MPO acquisition on generated compounds (Figure ). The average MPO score for all compounds generated by the end of the runs are 0.83±0.1 and 0.63±0.13 for the RL-AL optimized and 0.7 ± 0.135 and 0.53 ± 0.27 for the RL Baseline for ROCS and ADV, respectively (Figure ). In the RL-AL MPO case for ROCS and ADV respectively, we increase the average MPO score by ~87% and 56% relative to baseline and ~ 6% and 20% relative to the oracle acquisition RL-AL. To ascertain if the increase in average MPO score results in an increase in the MPO score for hits, we plot the cumulative density of hit MPO scores (Figure ). We observe that RL-AL optimized produces a higher density of hits at a lower MPO score for ADV, a pattern not observed for ROCS. For both oracles in the RL-AL MPO case all generated hits are found between MPO score [0.85, 1], leading to enrichment of high scoring hits relative to the RL-Baseline and Optimized case where hits are distributed between [0, 1].