Nevertheless, this behavior might change in media other than the gas phase. In terms of the robustness of typical CoGEF descriptors, we observed the greatest functional dependence for E max and the fracture strain in our CoGEF calculations. The relative deviation for F max is, in general, smaller than for E max , however one should expect differences up to 12 %. We summarized all predicted maximum forces for all model systems again in Figure . It is evident that the maximum forces to break polymer chains and activate mechanophores are overlapping. In other words, there is no clear fundamental separation between the ranges of maximum force to break a polymer moiety or a mechanophore. This means that there might be competing reactions depending on the polymer system and mechanophores used in novel mechanoactive polymeric materials. Non-covalent bonds can only withstand forces of at least one order of magnitude smaller than typical covalent bonds, based on the CoGEF calculations, which is an expected result.