They concluded that the relatively non-ionic polymer HPC markedly lowered the surface tension of water and also allow the contact between the polymer and poor water-soluble drugs. In this study, the water contact angle of tablets prepared by mixing S-309309 and a water-soluble polymer was evaluated. The results indicated that the contact between the water-soluble polymer on the tablet surface and the media lowered the surface tension of the water droplet on the tablet surface, leading to improved wettability of the S-309309based formulations.