A PLGA chain with increasing degree of polymerization (N = 16, 37, 64 and 87) was simulated in three different solvents, namely acetone (PPN), octanol (OTL) and water (W), at 300 K for 300 ns and 1 µs at atomistic and CG resolution, respectively. The gyration radius Rg was estimated over the equilibrated sampled trajectory and analyzed as a function of the PLGA degree of polymerization 𝑁 (Figure ). The exponent 𝜐 in the relationship 𝑅 ' ≈ 𝑁 S was estimated by a least-square fitting of the numerical data. The solubility trend observed at the atomistic level was qualitatively reproduced at a CG resolution: water and octanol are poor solvents (𝜐 values below 1/3) unlike acetone (𝜐 values above 1/2) for PLGA. A 𝜐 value lower than 1/3 for a polymer dissolved in water or acetone has been attributed to finite size effects and already discussed elsewhere by the authors . According to the empirical "like dissolves like" rule, an ideal solubility of PLGA in acetone would have been expected