The Mpro/CYP 3A4 score Pearson coefficient of the 15922 molecule scores docked is .33, a low correlation between binding strength of the molecules to 2 proteins. The 2 binding sites are from 2 proteins and are very different, and a high binding to Mpro with low binding to CYP 3A4 is a goal of the analysis. CYP 3A4 has a large and bland cavity in which molecules bind into; it isn't surprising that there is no correlation.