It should be noted that at high OEEF magnitudes, the S N 2 pathway becomes increasingly asynchronous, with the phosphate seemingly detached from the ribose in the TS structure. Nevertheless, full dissociation does not take place even at the highest electric field strength probed. Importantly, the increasing separation between the leaving group and the ribose, in combination with the persistent (partial) intramolecular charge transfer of 0.1e, causes the emergence of a huge dipole moment of 49 D, which, in the case of the reaction starting from the α isomer, in particular, is almost perfectly aligned with the reaction axis. It is this growing dipole moment that is responsible for the remarkable catalysis observed for this species.