As regarding the heatmap of interactions with bacterial proteins, the top-5 chemical classes are now "Organoheterocyclic compounds" (40), "Organic acids and derivatives" (34), "Phenylpropanoids and polyketides" (32), "Benzenoids" (30), and "Organic nitrogen compounds" (15). The sum of these interactions corresponds ~77% of all ones. In terms of target classes, now the distribution is even more concentrated in a few of them: "Transferase" (58), "Hydrolase" (51), and "Protease" (34) alone comprise ~72% of the interactions. Although in this dataset no significance is obtained from any of the chemical class vs target class combinations in the post hoc analysis of the contingency table represented in Figure , the four most populated combinations are the following ones: "Organoheterocyclic compounds" vs "Transferase" (16 interactions) and "Hydrolase" (13), "Organic acids and derivatives" vs "Transferase" (11); and 9 interactions are observed for "Phenylpropanoids and polyketides" vs both "Hydrolase" and "Lyase", as well as "Organic acids and derivatives" vs "Protease".