for vanoxerine synthesis was obtained on the gram scale using this catalyst-free strategy at room temperature, yielding 65% isolated yields. Additionally, the polyfluorinated ether 79d was successfully synthesized on a gram scale, and importantly, the post-functionalization of 79d yielded another unprecedented diether. To further investigate the value of the synthesized polyfluorinated ethers, we prepared a gram-scale derivative of flavanone bearing a hexafluoroisopropoxy group using this method (Figure ). This derivative was efficiently converted into other valuable compounds by using 1,1-diaryl scaffolds. Finally, the one-pot synthesis of hindered ethers directly from ketones was developed, offering a straightforward route, despite slightly lower yields compared to the use of N-tosylhydrazones (Figure ).