The assumption that biomolecular force fields must be parametrized against the experimental properties of small molecules has persisted since MM simulations began and remains in all force fields under widespread use. In this work, we look to challenge this assumption by deriving system-specific non-bonded parameters, from linear-scaling QM simulations, for consistency with the QUBE small molecule force field. These non-bonded terms were used here alongside libraries of (non-bespoke) bond and angle parameters, derived using the modified Seminario method, and newly reparametrized torsional terms.