Finally, we used the models to screen the CoRE database for potential ethane-selective MOFs that had not previously been explored for C2 separations. The screening results favor lanthanide-containing MOFs for ethane-selective adsorption, although this finding could be due to biases in the dataset. Assuming the results are not due to bias alone, we hypothesize that the additional coordination sites available to f-block metals allow for the formation of more structurally complex SBUs with favorable paraffin adsorption sites. Because La-containing MOFs have been somewhat understudied in the literature, this feature suggests that there are still more La-containing MOFs that have yet to be characterized for ethylene-ethane separations. We tested our ML model predictions by synthesizing lanthanum benzenetricarboxylate (La-BTC) and then obtaining ethane and ethylene isotherms. La-BTC exhibited moderate selectivity for ethane over ethylene, albeit lower than that predicted by the model, indicating that our ML models are useful for qualitative analysis. Ethane selectivity in La-BTC was found to strongly depend on pressure, almost doubling from 1.1 at the usual operating pressure of ~101 kPa to 2 at a pressure of 20 kPa since ethane has a sharper isotherm, highlighting the importance of making predictions across the full isotherm to co-optimize both the material and process conditions. The work presented here represents an important resource for researchers attempting to develop new, highly paraffinselective MOF adsorbents for pressing separations challenges.