Organophotocatalysts, including TETPY 16, PYTZ 17, eosin Y 18, and fluorescein 20, have been employed in the photo-assisted synthesis of benzothiazoles 29 under visible-light conditions (Scheme 4) . The work represents the first example of combining enzymatic catalysis with visible-light photoredox catalysis for the synthesis of 2-substituted benzothiazoles. This innovative methodology achieves target compound yields up to 99% within just 10 minutes. The proposed mechanism, consistent across these methods, begins with the formation of imine A through the nucleophilic addition and dehydration of 2-aminothiophenol and benzaldehyde under visible-light irradiation. Imine A subsequently undergoes intramolecular cyclization to generate intermediate B.