In order to determine the most suitable type of molecular features, the prepared dataset for each feature type went through a full QSAR pipeline with default configurations in the feature engineering stage. In this contribution, we define the term metaanalysis as the process where Wilcoxon statistical tests were employed to evaluate and compare the performance across all algorithms for each dataset. Similarly, subgroup analysis is defined as the application of Wilcoxon statistical tests to assess and compare the performance among the top-performing algorithms for each dataset. Details of these processes are shown in Fig. .