Another interesting example is the Niclosamide-TCSA pair (Figure ). Here, the parent drug, used typically as an anti-parasitic agent, was shown to exhibit antiviral activity but also significant side-effects. We do not feel qualified enough to judge if the side-effects of the TCSA bacteriostat are equally problematic. This being said, we note that this pair has a very good overlap and ShaEP score (Figure ), one of the best in our collection (and, interestingly, well above the average score in the family of COX-2 inhibitors mentioned earlier). Finally, connection between Tefonovir antiviral and Dyphilline antiasthmatic (Figure ) strikes us as non-obvious but relevant given COVID's respiratory symptoms. As for other pairs, this one also shows good 3D overlap (Figure ). We note that Dyphilline is also a progeny of another antiviral, Ribavirin, we discussed earlier.