To illustrate the effectiveness of this approach, we evaluated its potential using ALDH3A1 as a case study. ALDH3A1 serves a critical function in metabolizing a broad spectrum of aliphatic and aromatic aldehydes, safeguarding cells from oxidative damage, and maintaining cellular balance . Dysregulation of this enzyme is implicated in an array of diseases, such as cancers and neurodegenerative disorders, highlighting its value as a target for therapeutic intervention across these conditions .