The ILSA has been shown as a useful method for identifying mixture components using is-CID mass spectra. Since its initial presentation, several subtle but meaningful updates to the ILSA have further improved its utility. This note summarized the updates and demonstrated the algorithm improvements with an example application using a laboratory mixture of xylazine, acetyl fentanyl and heroin. We expect that the ILSA will continue to evolve and find potential applications outside of seized drug analysis as well.