For the conventional MFCC method with ACE-NME caps, the error amounts to 648 kJ/mol, i.e., it is already about a factor of four lower than for H-MFCC with hydrogen caps. This underlines that using hydrogen caps instead of ACE-NME caps significantly alters the description of the peptide bond and is thus not a good choice. When correcting only for the fragment-fragment interactions, the MFCC-MBE(2)-ff approach increases the error to 1,923 kJ/mol, demonstrating that the inclusion of the fragment-cap and cap-cap interactions is crucial. For MFCC-MBE(2), the error drops to only 56 kJ/mol, i.e., it is reduced by a factor of about twelve. Thus, including a consistent two-body correction dramatically improves the accuracy of the calculated total energies.