By comparing the thermograms and thermal events of the ASDs containing P1 (Figure , ). The Tgs of the extrudates were observed between 53 °C and 79 °C, depending on the polymer and drug content. As with P1 and P2, the Tg decreased with increasing drug content due to the plasticizing effect of IND. However, for these two polymers, the difference of the Tg for the two different drug loadings (50 and 80wt%) is about 20 °C, due to the much higher Tgs of the polymers themselves (Tg(P(VP-co-VA) = 103 °C and Tg(PVP) = 138 °C). In contrast, for P1 and P2, the Tg of the pure polymers and drug differ only by approximately 10 °C, resulting in a minor difference in Tg depending on drug loading. Additionally, the samples containing PVP or P(VP-co-VA) show a broad endothermic transition between 130 °C and 180 °C at 80wt% drug loading, presumably due to drug dissolution in the polymer, as for P1 and P2. Furthermore, none of the samples showing initial residual crystallinity in the first heating exhibited recrystallization of the drug upon subsequent heating cycles (data not shown). This suggests that for longer residence times or higher temperature during extrusion fully amorphous ASDs could be obtained even at 80wt% drug loading, albeit at the risk of drug degradation and/or polymer degradation.