We were able to scale the cyclization reaction with sulfamate epoxide 1 from 0.2 mmol to 5.1 mmol without loss of yield or selectivity (Scheme 6A). The hydroxy group of 2 was converted into the corresponding TBS ether and the oxathiazinane ring was activated by appending a Cbz group (Scheme 6B). 45 served as a very effective synthon for oxathiazinane ring opening by sulfur, nitrogen, and oxygen nucleophiles (Scheme 6B).