The main shortcoming of most current targeted HBM methods is the limited number of toxicants that are included. These are usually restricted to fewer than 20 analytes that belong to a single chemical group of either naturally-occurring or synthetic chemicals. It is challenging to design appropriate sample preparation schemes and chromatographic-and mass spectrometric parameters to enable the concurrent analysis of a multitude of structurally different compounds at trace levels. Consequently, multiple single-class methods need to be employed to achieve a broad assessment. This comes with high cost, additional labor, longer analysis times and the need for a higher sample volume.