The Wilcoxon signed-rank test was used to test whether the distributions of the lowest energy conformations found by each pair of search algorithms was statistically significantly different from one another, i.e. two-sided test. Here, the null hypothesis was that two related, paired samples (x, y), come from the same distribution. In particular, we compared three pairs of methods, namely (EI, Uniform), (LCB, Uniform), and (EI, LCB), and used a significance level of 5%.