The core receptors that recognize lipopolysaccharides are CD14, TLR4, and MD-2 . The receptor CD14 of lipopolysaccharide LPS exists in two forms: soluble form (sCD14) and membrane-associated (mCD14). Soluble CD14 (sCD14) plays an important role in enhancing the signal response to LPS in cells lacking CD14 on the cell membrane (mCD14) . It increased serum levels of soluble CD14 in asymptomatic patients infected with HIV or lymphadenopathy in normal controls . In SARS-CoV-2 infected patients admitted to the hospital, serum soluble sCD14 levels were also observed presents an increasing state . mCD14 is regarded as a useful marker molecule for monocytes and macrophages, and it plays an important role in binding the LPS-LBP complex and signal transduction . mCD14 binds to lipopolysaccharide and presents it to the TLR4/MD-2 complex, which starts intracellular signaling . The number of cell surface receptor mCD14 plays a significant role in developing sepsis . mCD14 is involved in the activation of monocytes induced by lipopolysaccharide(LPS). mCD14 is a bone marrow monocyte differentiation antigen expressed by monocytes, macrophages, and activated granulocytes . For example, mCD14-positive monocytes increase osteoclast bone resorption by 2-4 times, and osteoclasts are mainly derived from mCD14-positive monocytes . The lipopolysaccharide(LPS) in the blood induces the reaction by interacting with the lipopolysaccharide binding protein (LBP) in the serum. Then the complex stimulates the monocyte surface differentiation antigen mCD14 protein . Human monocyte mCD14 is upregulated by lipopolysaccharide . A low LBP concentration enhances LPS-induced monocyte activation, while the acute phase increase of LBP concentration inhibits LPS-induced cell stimulation . A decrease in plasma LBP is a surrogate marker for an increase in circulating LPS . In poorly controlled diabetes, mCD14 + monocytes are functionally activated, and markers of myeloid differentiation of monocytes and macrophages are detected .