The power of these radical cross couplings to simplify access to 1,2-amino alcohols is vividly illustrated through multiple case studies. The enhanced chemoselectivity and modularity of this approach led to truncated syntheses of 15 different known building blocks and natural products (Figures and), in some cases rather dramatically so. With regards to the most trivial substrates (Figure ), enantiopure functionalized amino alcohols 76-79 were accessed in a single step following acidic workup from RAE-10 (or it enantiomer ent-10-RAE). They can be found in various pharmaceuticals such as VTP-23 (81, treatment for cancer and autoimmune disease), SDZ MKS 492 (82, a potent PDE inhibitor), 31 ASTX029 (83, Phase I-II clinical trials for advanced solid malignancies), and enantiopure aminoalcohol 79 and 80, useful building blocks for the synthesis of highly selective asymmetric catalysts 84 and 85, could also be easily synthesized.