In the end, simple models are the language in which we understand chemistry. For the models to remain straightforward, exceptions and paradoxes are then inevitable. I have explicitly shown how unexpected behaviors often reveal limitations and gaps within these models, serving not as obstacles but as crucial indicators guiding us toward deeper insights. Such logic of scientific discovery, while long established, remains underappreciated in the field of chemistry, particularly within the context of organic chemistry. Often, obvious aspects can be overlooked for many years. I have presented a systematic approach to positively engage with these anomalies, as an attempt to reduce the oversight of obvious aspects. The origins of exceptions and paradoxes-from imperfect reasoning to the need to formulate new concept-underscore the need to challenge our presumptions and open to new paradigm. The categories discussed here are not exhaustive but represent one pathway to frame these phenomena, aiming to spark thoughtful discussion and promote intellectual open-mindedness. After my attempt, even if our understanding remains as clouded as before, advancing from muddled ignorance to informed bemusement is a huge (if not the greatest) progress that ought not to be underestimated. Instead of saying 'the more we know, the less we know,' I would offer a more positive and active rephrasing, 'the more we know, the more we know what we do not know,' and thus, opportunities arise to learn even more. Increasing the intellectual sensitivity to seize such "opportunities" is my fundamental incentive for writing this article. *Guanqi Qiu -Max-Planck-Institut für Kohlenforschung, Kaiser-Wilhelm-Platz 1, 45470, Mülheim an der Ruhr, Germany; orcid.org/0000-0003-3818-3896; Email: gqiu@kofo.mpg.de