Applications: The olefin major product is 1S,2S is useful for granzyme B inhibitrs , glutamate release inhibitors 31 , dopamine D3receptor ligands and channel blockers the minor product 1R,2R useful in synthesising the calcium channel blockers . -substituted olefins give highly functionalised 1,2,3-trisubstituted cyclopropane derivatives , which can be used to synthesize PCCG-4 and PCCG-13, the subtype-selective antagonists for metabotropic glutamate receptor. renin and retroviral protease . The diester-Cyclopropane were used for stereochemical studies 38,39, -bromo substitute in particularly important, the obtained cyclopropane derivatives can be further chemically manipulate to give 1-Aminocyclopropane-1-carboxylic acid derivatives (ACC) which constitute a family -amino acid of tremendous interest because of their biological activity and potential use in conformationally restricted peptides. The 1-methyl1-ester product, 1S,2S is useful for synthesis of neurodegenerative disorders inhibitos . Its major diastereomer product (1R,2R) is useful for the -amino acid , aspartic protease activity Coenzyme B12-