Following units for the rate as m -3 s -1 , the characteristic time for a single nucleation event scales according to 𝑉 -1 , the reciprocal volume of the solution. As described above, computational costs limit the total volume (number of atoms) that can be simulated using standard MD. With this in mind, consider a hypothetical aqueous solution system undergoing relatively fast nucleation with 𝐽 = 10 20 m -3 s -1 . In an MD simulation of this solution containing around 10 5 water molecules, we can expect the mean simulation time required to observe one nucleation event to be roughly one hour. This is far beyond the capabilities of MD, which typically achieves simulation times up to 10 -6 s on a powerful CPU/GPU. From this example, it is easy to appreciate why enhanced sampling simulations based on MD are often essential to study phase separation in some solutions.