The traditional shake-flask approach for partition coefficient studies that use octanol and water may sometimes involve pre-saturation of the biphasic systems for 72 hours, primarily because water is 20% soluble in octanol . However, due to the high-throughput nature of the experiments presented here and the number of solvent mixtures investigated, our experiments did not pre-saturate all of the solvent combinations. It is possible that the lack of pre-saturated solvents may introduce error in the solubility readings, which should be considered when performing final data analysis. Since traditional experiments typically focus on octanol/water, the benefits of the approach presented in this manuscript include the ability to perform experiments at a smaller scale using glass vials to explore a multitude of solvent combinations, and to allow the SAMPL participants an opportunity to determine if the range of solvent combinations are beneficial to data science and modeling.