In earlier investigations, our team demonstrated that ADCs utilizing Fc affinity-mediated conjugation exhibited superior stability and efficacy compared to those assembled using stochastic methods. Based on these findings, we further explored the in vivo efficacy of AJICAP-M-ADCs (Figure ). In this study, trastuzumab-AJICAP-M-MMAE and control ADC based on haloamide chemistry were evaluated using a HER2-positive NCI-N87 gastric cancer xenograft model.