Furthermore, the scalability of the protocol was demonstrated through the gram-scale ethylation of 4,7dichloroquinoline, which afforded 7 in 46% isolated yield alongside 28% of unreacted starting material (Figure , see Supporting Information). Similarly, the methylation of acridine proceeded smoothly on a 1.8 mmol scale, affording derivative 31 in 45% isolated yield. Taken together, these results highlight the utility of flow technology to enable the use of gaseous alkanes as alkylating agents at substantial reaction scales, previously unattainable (Figure ).