Moreover, four compounds (1-4) showed very high activity -pChEMBL value between 7.80 and 8.99against the two variants containing the resistance substitution T790M compared to the rest of the variants, including WTwhere the maximum pChEMBL value was 7.34. These two variants, single substituted T790M and double substituted T790M/L858R, also exhibited the most different overall bioactivity patterns, as expected given their biological relevance.