All compounds were synthesized by WuXi Apptec (China), based on instructions from the organizing team. 11,440 compound suggestions across 6 protein targets were provided to them. The compounds to be synthesized were selected based on 3 criteria by WuXi Apptec using proprietary methods: 1) cADME (computational absorption, distribution, metabolism, and excretion) filtering was done to arrive at compounds with molecular weight (MW) below 500 g mol -1 , CLogP < 5, HBA < 10, HBD < 5, TPSA < 140, Rotatable bond < 5. In addition, possible PAINS (Pan-assay interference compounds) were removed; 2) Chemical feasibility: a similarity search versus the WuXi Apptec virtual library was performed to assess feasibility; 3) reagent availability and cost were considered (approx. $245,000 in compound costs alone). After the selection, 1414 compounds were selected, and synthesis was started. The synthesis period lasted from November 2020 to February 2021, and 878 compounds were delivered as 20 mM DMSO (dimethylsulfoxide) stock solution on well-plates. It was not feasible to synthesize all compounds due to delays in the delivery of starting compounds or due to practical synthetic issues (e.g., low reactivity, difficulties in purification, etc.). The compound purity was determined by LC-MS and has been reported previously. Of all 878 compounds, 58 (i.e., 6.6%) had a purity below 90%, but were included in experimental assays nonetheless. The latter data set also includes information on solubility and compound chirality. Duplicate compound well-plates with DMSO stock solutions were shipped to the MIT-Broad institute (USA), Crelux GmbH (Germany), Pasteur Institute (France), and the Diamond Light Source (UK), for further experiments (see next sections).