To determine whether statistically encouraging DFT results in small-dimer data sets are somehow a fluke, it is necessary to extend these benchmarks to much larger systems where even dispersion-dominated interaction energies greatly exceed 1 kcal/mol. For vdW complexes with 100 atoms, dispersion interactions alone may exceed 50 kcal/mol in magnitude in some cases. Meanwhile, the role of dispersion in predicting conformational energies of bonded molecular systems is better recognized now than it was three decades ago, to the point where it is clear that dispersion forces cannot be ignored by the practicing organic chemist, as they may compete with steric repulsion and other nonbonded forces. Dispersion forces are also critically important in liquids and solids. Nevertheless, most benchmarking of dispersion-inclusive DFT methods has been limited to small nonbonded dimers. The uracil dimer, along with hydrocarbons up to pentane dimer, represent some of the larger systems in standard data sets, for which reliable CCSD(T)/CBS benchmarks are available without additional approximations. There are a few larger ab initio benchmarks, as surveyed recently, and DFT results for some of these larger systems will be scrutinized herein. Gas-phase experiments, based on cryogenic ion vibrational predissociation spectroscopy, suggest that small-dimer benchmarks may not provide a representative picture of the situation in systems with 150 atoms. At the same time, most experimental binding affinities for noncovalent complexes are measured in solution, and although these have occassionally been used as benchmark tests for quantum chemistry, the largest source of uncertainty is the solvation correction. Solution-phase benchmarks thus make for less incisive tests of how well dispersion is described by DFT, and will not be considered here.