Moreover, the chloromethylation of N-Boc protected 3-cyanoazetidine 142f, 3-cyanopyrrolidine 142g, and 4-cyanopiperidine 142h were accomplished by metallation of the compounds using LDA at -78 °C followed by alkylation with ClCH2I, resulting in β-chloropropanenitriles 143f-h (Scheme 21). Subsequent reactions with Snucleophiles could be carried out as mentioned above for the case of carbocyclic derivatives.