The signaling program as well as the associated changes in gene expression that affect the metabolic switch during T cell proliferation have been thoroughly explored and reviewed elsewhere . In contrast, our understanding of the changes in the metabolic state of cells is nascent but ever expanding . The first concrete explorations of metabolic rewiring accompanying the proliferation of healthy T cells occurred only two decades ago when it was shown that a switch to the proliferative state is accompanied by a significant upregulation of glucose uptake . This initial observation led to a flurry of research towards understanding the metabolic underpinnings of T cell function.