The identification of protein targets for small molecules plays a key role in multiple areas of drug discovery, since it allows the prioritization of compounds for the discovery of novel inhibitors against one or a set of therapeutic targets, as well as the estimation of their offtarget effects, which can be useful for the study of the polypharmacology of compounds and drug repurposing . The increase in the publicly available chemogenomic data over the years have led to the construction of multiple ligandbased models to predict the protein targets of small molecules, with some of these models available as web-based tools .