Most previous inquiries of SLE metabolism have studied metabolic pathways and nutrients in isolation, either by using only one approach (e.g. metabolomics or transcriptomics) or one metabolic pathway (e.g. glycolysis) as previously reviewed . In this perspective, we argue that the mammalian cellular metabolic network simultaneously carries out hundreds of interdependent chemical conversions , with large-scale dependencies and compensation mechanisms. Moreover, the metabolic network can be probed using multiple approaches, e.g. transcriptomics, metabolomics, and proteomics. Therefore, a comprehensive understanding of the impaired metabolic rewiring requires a simultaneous analysis of the exchange of nutrients and waste products and their relationship with cell proliferation and the cellular metabolic state.