NMR spectroscopy is widely used in chemical analysis. It is non-invasive, requires minimal sample preparation, and has increasingly better detection limits. High-resolution NMR spectrometers, based on superconducting magnets, can currently measure compounds at sub-µM concentrations. Another advantage of NMR is that it provides detailed information about molecular structures and their changes. Thus, NMR is ideally suited to the monitoring of chemical reactions. In the most straightforward approach, reactions are carried out in a standard NMR tube and monitored using spectra recorded at regular time intervals. In a more advanced approach, the reaction is carried out in an external reactor, and the reaction mixture is pumped through an NMR probe. The experiment typically involves a series of onedimensional (1D) H NMR, since they are fast to collect. The techniques can be improved by the application of advanced pure-shift methods or dedicated data processing. The twodimensional (2D) methods accelerated by the use of non-uniform sampling or single-scan techniques have also gained growing attention.