Interestingly, SOM I constitutes an exception, displaying a relatively low probability of HCB residing in the HS phase. This explains why, in SOM I, HCB exhibits diffusion comparable to that of water (see Figure ). Across all SOM systems, HS and water molecules are not perfectly mixed; instead, larger interconnected water regions exist, as previously noted for SOM II. The size of these regions is likely to be determined by the specific composition and arrangement of HS molecules. Particularly in SOM I, HCB diffuses within this water phase rather than integrating into the matrix formed by HS molecules, as identified from simulation trajectories.