EtBr was shown to cause consistent damage to mitochondrial , , , ribosomal DNA and non-nuclear DNA in different models leading to neurodegenerative disorders and higher risk of tumorigenesis , . Long term effects of EtBr induced mitochondrial DNA damage leading to rapid cellular ageing for the single individual and call also lead to infertility or other reproductive problems in animal models specifically infertility or early menopause , or spontaneous abortion while damage to Male sperm's mitochondria is also possible . To this end, the risk for mitochondrial has resulted in stringent Health & Safety procedures regarding EtBr use and, more specifically, concerning its disposal and detection . Concerning electrochemical detection of EtBr, reports in the literature exhibit limits of detection typically in the micro molar concentrations of range. This limitation of detection may not be fit-for-purpose for on-site detection as smaller concentrations of this substance may cause damage over time; thereby highlighting the need for a more sensitive detection method , . To date, electrochemical methods have been more successfully applied to remediation of the molecule , , rather than detection.