Sulfadiazine is an antibiotic molecule with a 4dimensional conformational space; its clinical relevance and intermediate complexity make it an ideal next step for the method outlined here. A 4-dimensional space is too high to allow a FES to be fully visualized while still being low enough that reasonable data density can be obtained (50,000 data points in a periodic 4D space results in an average density of roughly 32 configurations per rad 4 ).