We describe a standard procedure for the synthesis of QD4 in the presence of MLA and OAM (Fig. ). PbBr2, MABr, and MLA (racemic throughout this work unless otherwise noted) were dissolved in DMF to obtain a clear solution, to which OAM was added at room temperature under air (typically above 30% relative humidity) with a final molar ratio of MA:Pb:Br:MLA:OAM = 1:1:3:4:1.5. OAM is protonated by MLA to form OAMH + . We obtained a homogeneous white suspension by sonication. Negative ion mass spectrometric analysis of this suspension indicated that the insoluble white substance consisted of MLA -, Pb•MLA -, and PbBr3 -as dominant species (Fig. ). The aggregated Pb•MLA -chelate slowly dissociated and took part in the nanocluster formation (cf Fig. , blue) upon dilution with toluene under vigorous stirring for 3 h. A slightly milky toluene solution emitting weakly at »440 nm turned gradually pale yellow, and blue emission at »453 nm gradually intensified after an »120-minute-long induction period (Fig. ). After 3 h, the mixture was diluted with 0.5 volume equivalent of dimethyl carbonate (DMC) and centrifuged to obtain 1 as a pale green powder with PLQY of 95.6% on average. Repeating the synthesis with CsBr (Cs:Pb:Br:OAM = 1:1:3:1:2.3) afforded 2 emitting at 463 nm with PLQY of 97% on average after 1 h of reaction. Using D-or L-malic acid, the circular dichroism spectrum of purified 1 and 2 indicated a weak but clearly discernable Cotton effect overlapping with the major excitonic peaks (Figure ), indicating that the MLA molecule is bound to the nanoclusters . There was no emission of circularly polarized light.