Dissolution studies. Reformulating TBZ into salts resulted in a notable enhancement of solubility. The dissolution rates of TBZ and its salts were measured in an aqueous environment at 37 °C over 30 minutes (Figure ). We selected these specific experimental parameters to simulate the conditions of the oral cavity, considering the oral route of administration. As expected, the solubility of the molecular form of TBZ in water was low, reaching saturation at 0.038(3) mg/ml. HTBZ-HFU was observed to have only a slight increase in solubility compared to molecular TBZ, reaching a concentration of 0.18(2) mg/ml (approximately a 4-fold increase).