From a global health perspective, initiatives directed to the improvement of rapid data sharing are critical during health emergency. This rapid sharing includes undoubtedly a transboundary collaboration founded on the principles of reliability and accuracy of the data . Meaningfully, for preventing potential new or existing pathogens to become high threats to human health and global security, non-commercial basic research on microorganisms should be assured. Additionally, introducing and promoting genomic epidemiology and strengthening global laboratory alliances would contribute to the national and global rapid detection and containment of outbreaks, as also promoted by the WHO. Accordingly, every country is sovereign and should guarantee the protection and regulation of the use of its biological resources, specifically working towards the Fair and Equitable Sharing of Benefits. Nevertheless, international conventions on the topic and national legislations should include fast track options for research on pathogens . Relevantly, the links between human, environmental, and animal healththe One Health approach-are widely recognized to be effective towards the prevention and reduction of the emergence and re-emergence of potential pandemic agents 123 . This, not only pursuing to diminish the impact of epidemics or pandemics in the health systems, but also to underpin and reinforce economic, development, and social benefits. Drug repurposing analyses applying artificial neural networks. A) Bestpredicted experimental compounds per immune system protein target. B) Best-predicted compounds under investigation per immune system protein target. C) Best-predicted approved drugs per immune system protein target. D) Best-predicted multi-target experimental compounds, compounds under investigation, and approved drugs. AUROC: Area under the receiver operating characteristic.