The observation above is particularly concerning because the latter functionals are still commonly used in reactivity studies. Oftentimes, a handful of benchmarking data points, indicating that these functionals do not perform dramatically worse than more modern functionals, are used as justification for their selection, as the BLYP and B3LYP functionals tend to also be among the fastest to evaluate. This preliminary analysis however already demonstrates that caution is needed in this regard, as trends emerging in local patches of chemical space may not always hold beyond them.