The collection underwent analysis on an analytical platform capable of conducting UHPLC-HRMS 2 metabolite profiling in both positive (PI) and negative (NI) ionization modes. Supplementary data were also recorded using a Photo Diode Array (PDA) and a Charged Aerosol Detector (CAD). The CAD provides numerous benefits, including universal detection, sensitivity, robustness, versatility, and compatibility . The incorporation of semiquantitative detectors in NP chemistry offers a practical and cost-effective method for screening, analyzing, and characterizing NEs . Depending on the scope of the study, the availability of semiquantitative data assists in rapidly identifying features of interest and assessing whether the isolation of such compounds is worthwhile. Furthermore, semiquantitative detectors allow for a more detailed examination of the actual composition of a sample, providing a closer and more comprehensive understanding of its chemical constitution.