In the assessed timescale, the obtained results indicate that short MD simulations may capture useful steric conformation changes and that longer MD simulations may contain more random movements or noise, which may lower the individual correlation of some of the ts_descriptors. Similar results have been presented in works concerning single targets . Taken together our results show that time series descriptors from longer MD do not provide advantage over short MD runs, possibly due to higher noise content and increased noise fitting during model training.