Here, we assessed the AMOEBA polarizable force field for modeling carbohydrates in solution. AMOEBA includes explicit polarization for water and carbohydrates via induced atomic dipoles, as well as a buffered 14-7 Halgren potential for van der Waals interactions, which addresses the limitations of other force fields listed above. We used Poltype 2 to compute new AMOEBA parameters for the α and β anomers of D-glucose (Glc), D-glucosamine (GlcN), N-acetyl-Dglucosamine (GlcNAc), D-galactose (Gal), D-galactosamine (GalN), and N-acetyl-D-galactosamine (GalNAc), shown in Figure . Using the new Poltype 2 AMOEBA parameters, we performed an energy minimization, followed by 150 ns MD simulation of each monosaccharide in water with constant number of particles, pressure and temperature (NPT) in Tinker 9. The first 5 ns of the MD were used as equilibration and the remaining 145 ns as production run to compute the properties described below. Each simulation was run twice, once with mutual polarization, converging induced dipoles at each step within 10 -5 D, and once without the dipole polarization term (see input files in Supporting Information).