This study seeks to assess the capability of the SMx (x= 12, 8, or D) universal solvent models for predicting limiting activity coefficients . The SMx universal solvent models are implicit or continuum solvent models that can compute solvation free energies at 298.15 K using electronic structure calculations. The models have long been under active development with their accuracy continuously improving and are implemented in a number of software packages . The only input needed from the user is a structure of the molecule; therefore the SMx models are set apart from other methods in the sheer simplicity for the user. Of specific interest to us is their potential future use to parameterize binary interaction excess Gibbs free energy models for phase equilibrium predictions. In addition, a major goal of this work is to determine how best to predict limiting activity coefficients using solvation free energies computed using the SMx universal solvent models. Specifically, as will be shown, the prediction of the limiting activity coefficient is dependent on both the solvation free energy and self-solvation free energy. While the self-solvation free energy may be computed directly, it may additionally be computed from readily available vapor pressure data.