The ZIF-8 particles drop casted on a Cu TEM grid and then loaded on a Gatan 626 cryo holder at room temperature. Cryo TEM experiments were done using a ThermoFisher Tecnai microscope operated at 200 kV and a ThermoFisher Titan operated at 300 kV, respectively. Once the holder was inserted into the microscope, the sample was cooled to -176 ºC using liquid nitrogen. After a 30-minute wait to stabilize the temperature, the ED series acquisition process followed the same steps outlined in the diffraction experiment. The dose rate and exposure time were kept constant at 1 e -Å -2 s -1 and 1 sec, respectively, for both experiments.