Every protein-ligand pose in each dataset has two labels. One label is binary, indicating whether the pose is less than or equal to 2 Å RMSD from the ground truth ligand conformation. During redocking experiments, the crystallographic pose of the ligand within the target protein serves as the ground truth. During crossdocking evaluations, the ground truth is designated as the ligand pose after alignment of the cognate protein structure with the receptor conformation used for docking. The second label provides the experimentally determined binding affinity of the protein-ligand complex. For the CrossDock2020 dataset, ligands are assumed to have the same affinity for all receptors of a given pocket. Rather than using the raw K d of the complex, we take thelog 10 (K d ) to teach the scoring functions the magnitude of the complex's binding affinity.