Stem cell-based therapies have emerged as a promising avenue in the ART, leveraging the regenerative and differentiation potential of stem cells to enhance reproductive outcomes. It is paving the way for advanced reproductive treatments. The application of stem cell-based therapies in ART relies on their ability to: (i) differentiate into reproductive cell typesfor example, inducing embryonic stem cells or induced pluripotent stem cells to form oocytes or sperm; (ii) secrete growth factorsstem cells release paracrine signals that enhance tissue repair and cellular function; (iii) integrate into host tissuestransplanted stem cells can integrate into reproductive tissues, contributing to structural and functional recovery.