It has previously been demonstrated that multi-pass cIM data can be "unwrapped" by using 0-pass, 1pass, and multi-pass cIM routines in conjunction to calculate the periodic drift time and number of device passes per ion . Utilization of this technique in HDMS E workflows would be beneficial for bottom-up LC-MS applications such as HDX-MS, as the derived periodic drift times could once again by used to auto-calculate trendlines which correlate drift FWHM with drift time. Ideally, instruments would dynamically switch between different cIM routines throughout HDMS E experiments, in a manner analogous to low energy/high energy switching, to provide 0-pass, 1-pass and multi-pass data simultaneously.