The initial stack of talktorials T001-T010 covers common CADD tasks involving webserver queries, cheminformatics, and structural bioinformatics . We show how to fetch chemical and structural data from the ChEMBL and PDB online databases and how to encode, filter, cluster, and screen such datasets to find novel drug candidates and off-targets (Figure , T001-T010). The TeachOpenCADD platform enjoys wide usage in the community, as exemplified by frequently posted GitHub issues, about 13, 000 article views , over 250 GitHub repository stars and about 90 repository forks (as of 2021-10-14) as well as teaching feedback . The cheminformatics-focused talktorials are inspired by a variety of online resources, which we recommend for further reading; e.g. the virtual screening tutorials in context of the Teach-Discover-Treat initiative , and several blogs such as Practical Cheminformatics , the RDKit blog , Is life worth living? , and Cheminformania . Another prominent example for a cheminformatics code collection is the Chemistry Development Kit (CDK) .