The LEF5500 library-derived data set and the two Enamine data sets were compared. Figure shows the populations of the different fluorine motifs in the different data sets. The LEF5500 (Figure ) was the largest of the data sets, larger than both Enamine data sets put together. The LEF5500 also had the highest proportion of CF3 containing compounds in comparison to the two Enamine data sets. The LEF5500 also extended most into the -130 to -230 ppm range, which was a direct result of the expansion strategy described in the previous publication. The two Enamine data sets, FDS-1000 (Figure ) and the FFL-d6 (Figure ), had different distributions of fluorinated motifs. All data sets had a similarly low proportion of CF2, the least represented fluorine motif, which is likely due to its NMR appearance described above.