Although several studies suggested the use of GAG-based biomaterials for tissue engineering, to control inflammation, inflammatory cells can release proteases and glycanases that mediate degradation of collagens and GAGs in the extracellular matrix . To avoid the degradation of GAGs in biomaterials, several strategies have proposed GAG-mimetic designs . The generation of low molecular weight heparin-poly(ethylene glycol) conjugates was proposed for the design of hydrogels, crosslinked by heparin-binding peptide-conjugates, and enabling the capture of basic fibroblast growth factor and vascular endothelial growth factor . Similarly, the design of a range of sulfated maltose oligo-dendrimers (e.g. presenting 4 arms each displaying sulfated dimers) allowed the identification of a particularly strong heparin biomimetic candidate to enhance BMP-2 activity in vitro and bone regeneration, although this required multi-step synthesis .