From biased simulation, we determine the permeability coefficient for these compounds across the sorghum plasma membrane. The molecules are determined to be highly permeable, with bilayer transit for limited primarily by desorption from the membrane. Desorption from the membrane can be facilitated by large droplets of an organic phase. While permeable, concentrations within the host are limited by the number of membrane jumps between root cells that generate sorgoleone and photosynthetic cells sensitive to sorgoleone, mitigating autotoxicity. Thus, we find that sorgoleone likely is transported passively across membranes and through plants, rather than being actively exported to maintain low sorgoleone concentrations inside a sorghum cell.