To obtain information on how much of the host-guest interaction is due to solvophobic effects, we calculated the reduction in the Solvent Accessible Surface Area (SASA) of the 2 cis conformer when this is encapsulated in the cavity of the various complexes vs. when this is alone in solution. While a correlation with the computed reaction acceleration is observed (see Figure ), the trend becomes less neat. The trend is respected while moving from the amide in solution to mono-guest (2 ⇢ 1) and double-guest complexes (2 2 ⇢ 1 and