By computing potential of mean force (PMF) between two neopentane molecules, Su et al. also showed a higher association at contact distance in TMAO solution relative to that in pure water using Netz model. A similar kind of observation was pointed out by Ganguly et al. and they explained the fact as the TMAO is more hydrophilic in nature in Netz force field. Possibly for this reason, we can observe second highest contact pair population in water-TMAO for Netz force fields. Contrarily, the lowest population is noticed in water-TMAO when Garcia force field is employed for TMAO. This is possible because the TMAO is less hydrophilic in nature. So, in TMAO solution the neo-neo association at this state is very sensitive and quite dependent on the force-fields.