Since the 1990s, it has been suggested that hazard-related concerns of TFA and other shortchain PFAAs are much lower than those of PFAAs with longer perfluoroalkyl chains, which are more bioaccumulative in lipids and generally more toxic . However, these early reports did not consider TFA's ubiquitous accumulation in the environment, in particular its observed accumulation in water resources and bioaccumulation in plants and crops. Although there are fewer toxicological data compared to long-chain PFAAs, we maintain that there are more than sufficient data to conclude that TFA poses a risk to humans and the environment and meets the criteria of a planetary boundary threat for novel entities . We will present evidence for this based on TFA's 1) increasing planetary exposure, which is 2) irreversible and accumulating due to emissions from many sources and could thereby cause 3) long-lasting disruptive effects on human health and vital earth system processes. Our analysis leads to the conclusion that policy, industry initiatives, and innovation actions should be enacted globally to reduce TFA emissions as soon as possible and to protect future generations from potential irreversible effects of TFA accumulation.