Concerning MF B, GNPS spectral library was able to annotate the node at m/z 717.4359 (appearing as a triangle in Fig. ) as pleiokomenine A 33 , a bisapidofractane-type monoterpene indole alkaloid already reported from this plant. In addition to this annotation, MS2DECIDE's indicators showed elevated agreement between the three tools (tg,s = t g,i = t s,i = 1), which significantly strenghtened this annotation. An analysis of the ranks proposed by MS2DECIDE for the features of this MF indicated that all the features were assigned a better rank than pleiokomenine A (741/754), regarding their potential novelty. Remarkably, feature at m/z 817.4137 was the best ranked (92) In the manufactured case, an inspection of the ten first ranked results of the chemodiverse library (Table ) revealed that MS2DECIDE is able to correctly prioritize previously unreported compounds (ids 90-95). As a tool based solely on annotations of MS/MS data, MS2DECIDE is however unable to detect false-positives (products) when all tools agree on incorrectly considering a given product as novel while yielding very different closest matches, as illustrated in Table .