The utility and generality of this methodology prompted us to further evaluate it on a multigram scale (Figure ). The key issue to be addressed was the feasibility of using a sacrificial electrode in a flow electrolysis setup. Conventionally, such system is not preferred due to the constant alteration of electrode distance and surface area caused by electrode consumption, raising some risk to operate the reaction reliably on scale. However, employing a sacrificial anode could be valuable to avoid extensive, time-consuming re-optimization campaigns to determine alternative paired electrolysis conditions. With regard to the preparation of a large quantity of RAE for our scale-up study, it was discovered that isoindolinone-type RAE 107 is preferable due to its high crystallinity, which removes the necessity of chromatographic purification on large scale. The change of the backbone does not compromise the stereoselectivity of the coupling, and the enantiopure aminoalcohol can be readily liberated by the treatment of the coupling product with hydrazine.