In comparison with other similarity measures -focusing on the pocket sequence (KLIFS seq), interaction profiles (KLIFS IFP ), or topological-and chemical pocket properties (SiteAlign) -KiSSim performs equally or slightly better in most cases. The sequence-and IFP-based measures are easy and fast to compute thanks to the preprocessed kinase pockets available at KLIFS; we recommend to include these datasets in any case when investigating kinase similarities. SiteAlign is a powerful tool to compare pockets across all protein classes; if interested only in kinases, KiSSim is a kinase-focused and faster alternative with slightly better results in most of the investigated cases.