Finally, we showcase the binding of a hevein to a crystal PET film, allowing us to identify interacting protein residues and demonstrate the role of electronic polarization in driving such interactions, which led to an average interaction energy between hevein and PET film almost 20 kcal/mol stronger than in the additive model. Lastly, we mapped and quantified how hevein binding to the PET film modulates the electrostatic potential surface, which could be a strategy used to design better PET binders. Together, these results represent the first extension of the Drude polarizable force field to synthetic polymers. We demonstrated how important the inclusion of explicit electronic polarization of materials is in describing PET material properties and how these outcomes can help designing more efficient (bio)technologies to tackle the plastic pollution crisis.