The binding interactions as viewed on Discovery studio visualizer shows that all the selected compounds have good poses on the receptors Table -11. While compounds 19d and 21d had five and seven hydrogen bonds respectively with plasmepsin II residues in addition to other hydrophobic bonds (Fig. and 2) which is in line with their low binding energy. Compounds 13d, 15d, and 21d had three hydrogen bonds each with the Falcipain 2 residues in addition to other hydrophobic interactions (Fig. and). With Falcipain 3, compounds 13d had five hydrogen bonds in addition to other hydrophobic interactions (Fig. ) whereas compounds 4b (Fig. ), 4d, 7c, 8c, 11d, 13a, 18d, and 21d had three hydrogen bonds each with the receptor residues (Table ). Compounds 7c and 11d had six and four hydrogen bonds respectively with SUB1 residues in addition to other hydrophobic interactions (Fig. and). From the molecular simulation results