The crystal sponge (CS) method, first reported by Fujita and coworkers in 2013, has become an important technique in the structural elucidation of compounds considered "uncrystallisable". The technique removes the necessity of sample crystallisation by utilising the porosity of crystalline metal-organic frameworks (MOFs) to form host-guest complexes with the desired compound, which can then be analysed by SCXRD. The CS method is particularly useful in pharmaceutical research, where knowing the exact structure and stereochemical information of a molecule is of critical importance.