Similar to the selector used, the flexibility mode used to generate ligand poses does not have a significant impact on the correlation between score and binding affinity (see Figure ). While the fully-flexible methodology has a significant advantage for the kinases ABL1, JAK2, and CHK1, (Figure ) there are few other examples where the fully-flexible method provides a clear advantage over the semi-flexible and rigid methodologies (Figures and). Again, this is significant because these methods are less computationally demanding than the fully-flexible method and can be used quickly in a virtual screen pipeline.