Intracellular structure and dynamics are crucial for function and regulation in biological systems. Micro-and nano-scale transport mechanisms play an important role in the spatiotemporal organization of cellular sub-components. For instance, motor proteins and self-organizing metabolic systems are well known. Transport of intracellular matter by purely physical means has been less explored, though recent studies reveal that diffusiophoretic mechanisms can arise from metabolic inhomogeneities or ATP-consuming protein systems. In particular, theoretical work has shown how metabolite gradients may impart nonmotor forces on nanoscale complexes , while experiments on an ATPase system demonstrate purely friction-mediated cargo transport in the absence of dedicated motors . These findings underscore that nonequilibrium processes beyond canonical motor-based pathways can substantially shape intracellular organization.