Consistently good activity was observed against C. auris as well as with two Cryptococcus strains. Promisingly, Au3 showed no haemolysis up to 200 µM and CC50 values in the range of 138.9-170.4 µM (Table in SI), resulting in a therapeutic index of 44. The low toxicity values combined with signs of structure-dictated activity profiles suggest that synthetic explorations could yield even better compounds of this class.