Apelin is a bioactive peptide initially discovered in bovine stomach extracts by Tatemoto et al. in 1998 . It is acknowledged as the inherent ligand of the human G protein-coupled receptor APJ (APLNR) and a seven-transmembrane receptor akin to the angiotensin-type 1 receptor 1 . Apelin is a precursor protein composed of 77 amino acids, undergoes hydrolysis to yield active peptides of varying lengths, including Apelin-36, Apelin-31, Apelin-17, and Apelin-13. The apelin/APJ system is instrumental in the physiological and pathological functioning of numerous organs, influencing fluid homeostasis, blood pressure, cardiac contractility, angiogenesis, metabolic equilibrium, cell proliferation, apoptosis, and inflammation 2 . Furthermore, the apelin/APJ system exhibits extensive expression in the central nervous system, predominantly in neurons and oligodendrocytes .