A significant advantage of GaMD is that CVs, which describe the state of a molecular system, are not needed. Identifying the appropriate CVs for a particular system is still an active area of research and can be difficult for new or unfamiliar systems. In contrast, metadynamics requires CVs to be chosen a priori, which similarly fills energy wells with repulsive Gaussian potentials. However, metadynamics does not suffer from having unconverged high energy regions like GaMD since metadynamics recovers the original free energy landscape as the opposite sum of all Gaussians. Nonetheless, GaMD is one of the few enhanced sampling methods that do not require tuning of many parameters and can be easily applied to various systems. Additionally, GaMD is fully implemented in Amber 84 (starting from Amber16) and NAMD 85 (starting from 2.13), 2 which makes it easier for users to use the method.