The Omicron spike trimer was modelled by SWISS-MODEL Server in Alignment mode . The Omicron homology model with the RBD up was chosen for further analysis. The Omicron spike were superimposed to a WT spike/ACE2 complex (PDB ID: 6vw1 ) to create an Omicron-ACE2 complex. We retrieved 3 marketed or clinical RBD-specific antibodies bound to S protein from the Protein Data Bank. The Omicron RBD domain containing residue 334-526 were truncated from the full-length S protein.