As a nascent and fledgling field, the development of integrated catalysis still faces many challenges. First is the issue of compatibility. Compatibility considerations in integrated systems is multifaceted and includes the compatibility between catalysts, reagents, solvents, and reaction conditions. When different reaction cycles are carried out in one pot, the catalysts may undergo mutual deactivation or decomposition caused by the substrates or cocatalysts of another reaction. In principle, switchable catalysis circumvents the problem by generating different catalytic species at different times, while spatial control can be used to separate different precatalysts. Furthermore, when different reactions require different conditions, such as temperature and pressure, reconciling such disparity is pivotal. Again, spatial control becomes important by separating such reactions in different microenvironments, e.g., by compartmentalization, immobilization, or creating a local concentration gradient.