The co-occurrences of the genetic risk factors and the pharmacological targets concepts in the documents of the CAS Content Collection related to AD are illustrated in Figure . APP co-occurs in documents with all target proteins, but with highest frequency with BACE1 and PD-4; ApoE most frequently co-occurs with TDP-43 and ACE, and PSEN-1 -most frequently with GSK-3β and JNK.