Our convolutional Siamese network shows improved performance over the model developed by Jiménez-Luna et al. on the retrospective lead optimization dataset. However, we do not show the same increased performance over Jiménez-Luna et al. when evaluating on external datasets. Most of our loss components enhance the performance of our models for RBFE prediction, especially the L consistency component. Our models show reduced performance when evaluated on protein families that have never been seen in comparison to our retrospective lead optimization evaluation.