In conclusion, we present a fully automated workflow for residence time calculation and highlight its ability to generalize across diverse chemotypes and timescales while maintaining accuracy and performance. This workflow was tested on a range of protein-ligand complexes to ensure its effectiveness. We anticipate that this work will serve as a basis for generating valuable data for understanding drug unbinding mechanisms and that this easy-to-use workflow will enable more discovery programs to leverage kinetics-based insights. fastest unbinding ligand, 4a, had moved more than 2.5 Å from its initial bound pose after 100 ns so we instead thermalized this system for the standard 10 ns.