However the highest 5 scoring docked CS molecules in the S197 resistant calculation are epitopes outside the cavity and 'down a hill' from the interior region. These are far from the active site and should not be considered in the comparison. There are no outlier states at high score in the susceptible strain. Redoing the Boltzmann statistical calculation gives, < 𝐸 𝑖𝑛𝑡,𝑠𝑢𝑠𝑐 >= 41.4 (6.4 𝑘𝑐𝑎𝑙) < 𝐸 𝑖𝑛𝑡,𝑟𝑒𝑠 >= 38.4 (5.9)