Thus, the diverse nature of RNA has distinctly differentiated RNA nanotechnology from its DNA counterpart. In the evolution of programmable molecule engineering, DNA droplets, liquid-like condensates of wellengineered DNA sequences, have attracted increasing attention as dynamic intelligent fluid 37 that bears high programmability in interactions, physical properties, and phase behaviors. They are model systems of biomolecular condensates naturally derived in biological cells. Biomolecules, primarily proteins, and RNAs, 41 can selectively phase-separate into membrane-free organelles through multivalent molecular interactions. Such dynamic nature allows biomolecular condensates to operate out of equilibrium, thereby facilitating the organization and functionality of biological cells. DNA droplets as programmable out-ofequilibrium model systems can offer a promising alternative to the highly sought-after membrane-bound structures in artificial cell studies. Recently, DNA droplets have been demonstrated to carry out AND logic operations by programming a droplet of cross-linked orthogonal DNAs to phase-separate into distinct phases via strand displacement reactions. Despite the great potential, it appears that the previous efforts in programmable droplets have paid less attention to RNA as a design material, with an intensive focus placed on SE-assembled DNA droplets and their structuring aspects. The limited repertoire would overshadow the potential growth of programmable droplets into widespread applications that could match the overwhelmingly diverse RNA world. One appealing research direction would be functional RNA droplets, which might enable the in situ assembly of sensing devices in biological/artificial cells. RNA-based logic operators reported thus far have yielded no macroscopic output, which might serve as an appreciable readout without requiring additional setups. In addition, synthetically derived RNA droplets expressed in biological cells have relied on CAG or CUG repeat expansions as a means to establish multivalent interactions, still lacking design flexibility.