Although antagonist molecules in all DS don't was associated with molecular complexity, nevertheless, For LasR antagonist compounds, it was identified that the side chain size should range between 10 and 12 members in homoserine lactone scaffolds. In contrast, in triphenyl scaffolds, the substitution of rings generates a specific type of activity. In the molecules active against PqsR the size of the side chain in quinazoline rings and substitution in the nitrogen of the third position derive in a determinate type of activity.