Experimentally, dialysis is very simple. During incubation in a dialysis bag, the nanocarriers release the encapsulated drugs, which are then collected and quantified. The structure of ultracentrifugation is very similar to dialysis, except for sample collection. In this method, the nanocarriers are sedimented in a solution by ultracentrifugation, and a sample is then collected from the supernatant. A solution without nanoparticles and drug (vis-à-vis, blank solution) is added to restore the initial volume. The particles are then redispersed in the solution to ensure their re-release. This description shows that ultracentrifugation is somewhat tedious and labourintensive compared to dialysis. It is suggested that multiple cycles of sedimentation/redispersion could affect the structural integrity of nanocarriers, but this has not been proven.