The DLS investigation (figure and) showed that during this release process, the mean diameter of the DT-entrapped Brij micelles progressively reduced, indicating that DT had been released from the micelle. Robust interaction between drug and micelle frequently encourages delayed drug release. This is advantageous for DT's regulated release . This longer release period may be caused by the larger size of Brij 58 micelle compared to the Brij S20 . An intriguing option for both DT distribution and reducing its degradation is the use of stimuliresponsive Brij micelles loaded with DT. Here, pH acts as a vital stimulus that facilitates the Brij micelles to release the DT from its core by altering the peripheral hydrophilic surface moieties of the Brij micelles . Thus, the produced "DT loaded pH-sensitive micelles" demonstrated superiority in terms of preserving the shelf life of DT and the amount of time needed for its release when compared to several earlier traditional approaches .