To address this methodology gap, we adapted a cryogenic correlative light and electron microscopy (cryo-CLEM) platform for studying oxidation in food emulsions. CLEM is an emerging technique that combines information from fluorescence microscopy and electron microscopy performed at similar regions within a sample . CLEM has been developed and applied mainly in the life science allowing, for example, the correlation of nanoscale structural information with the localisation of specific, fluorophore-labelled biomolecules . Correlative imaging approaches are also relevant in other scientific fields such as polymer science . For performing transmission electron microscopy (TEM) at native conditions, CLEM typically requires laborious sample preparation steps such as chemical fixation, staining, resin embedding, and cutting, all of which may lead to potential artifacts . The use of chemical fixatives can be circumvented by utilizing rapid cooling of samples, such as with plunge vitrification or high-pressure freezing and measuring the samples at cryogenic temperatures. In fact, it has been reported that cryo-fixated samples expose better preserved structures as compared to chemically fixated samples .