To promote larger clusters by HDBSAN and favor larger clusters by volume, we set the epsilon and volume weighting parameters to 0.22 and 4 respectively. By doing so, the membership post downsampling was decreased to 657 molecules, a 12% reduction in error due to elimination of miniscule clusters. The increase in cluster sizes is clearly illustrated in the UMAP plot generated using the visualization flag (Fig ). Overall the command line functionalities and rapid visualization included in Dedenser allows for user friendly curation of downsampled chemical libraries.