Figure shows a visual representation of the chemical space of Nat-UV DB based on ECFP4 fingerprint using t-SNE. Figure ) compares Nat-UV DB with other natural products databases (i.e. LANaPDB, BIOFACQUIM, and UNIIQUIM) and approved drugs. Interestingly, Nat-UV DB shares part of its chemical space with the approved drugs dataset, but Nat-UV DB compounds are more distributed in the three dimensions of the plot, which suggests that have a higher structural diversity than the approved drug dataset. However, LANaPDB (the largest dataset analyzed in this study) has an apparently higher structural diversity than the other studied datasets. To quantify the diversity of each dataset, the calculation of structural diversity and scaffold diversity were done (Figure ). To quantify the diversity of each dataset, we calculated the mean of the paired similarity of the structures (x-axis) and scaffolds (y-axis) based on the similarity of each pair of compounds in the dataset using ECFP4 fingerprint and Tanimoto coefficient, where the higher values confirm a higher structural or scaffold diversity of the dataset. These results showed that Nat-UV DB has a higher structural and scaffold diversity than the approved drugs. However, it has low structural and scaffold diversity in contrast with UNIIQUIM and LANaPDB. Finally, Nat-UV DB shows a higher structural diversity than BIOFACQUIM, but a lower scaffold diversity than this one. Nat-UV DB is a compound database of natural products from the state of Veracruz in Mexico, which is a coastal zone reported with a large biodiversity. The open-access database contains 227 compounds reported from 1970 to June 2024, which is available at . The compound database contains information of bibliographic resources for each compound, information about the collected species that come from, and cross-referenced bioactivity data. The chemoinformatic characterization and analysis of the coverage and diversity of Nat-UV DB in the chemical space suggest broad coverage, overlapping with regions in the approved drugs chemical space. The analysis also indicated that there are unique compounds in Nat-UV DB concerning other Mexican and Latin American natural products databases. The main perspectives of this work are to use Nat-UV DB to identify active compounds using virtual screening methods and continue to augment the size of Nat-UV DB from the new natural products that would be identified in the state of Veracruz, Mexico.