Programs like pytc or SEDFIT provide methods to perform a global fit, that is to fit a single set of parameters to more than one experiment. In that fashion, analysing several signals in NMR titrations is already a global fit, since one formation constant is connected to two or more signals. While a global fit for NMR titration is straightforward, combining several ITC experiments is performed with MetaModels in SupraFit. MetaModels are empty container models, that can hold and manage real models. Model parameters can be handled individually or any in combination thereof. However, the first approach is identical to a local fit. Statistical analysis or global search can be performed on MetaModels in the same way as on simple models. An example of MetaModels will be discussed in the ITC section.