where V pre, i is the contribution to the computed ESP at site i calculated with AM1 population charges, and V ind, i is the contribution from induced dipoles. The BCCs are fitted by minimizing the sum of χ 2 over all conformers of a training set of 119 molecules (Section 2.4), much as detailed in Equation . Once the BCCs have been optimized, the AM1-BCC-dPol method allows both polarizabilities and polarization-consistent partial charges to be assigned to a new molecule as quickly and easily as partial charges alone are assigned with the traditional AM1-BCC method.