Additionally, we looked at two different metrics to compare performances: the number of non-dominated solutions (i.e. peptides) found and the hypervolume. A solution is called nondominated if the solution is not dominated by any other solutions in any other objective dimensions, and the Pareto front defined as the ensemble of nondominated solutions found during the optimization, all of which are considered equally good. The hypervolume is defined as the volume of the objective space between the current Pareto front and an anti-utopian point, here set at , with the goal of maximizing it.