The coupling between disease states and treatment approaches highlights the critical interplay between biochemical alterations and tissue biomechanics. In conditions such as hypertrophic scars, the remodeling processes are intrinsically linked to chemical signals that direct collagen deposition and degradation . Non-invasive treatment strategies, such as pressure therapy or silicone gel applications, directly target the biomechanical aspects to improve appearance and function. Topical corticosteroids for eczema reduce inflammation but can also thin the skin, altering its mechanical resilience . Similarly, systemic therapies targeting tissue necrosis factor-alpha (TNF-α) in psoriasis patients not only modulate inflammatory pathways but also affect skin elasticity and barrier function. Furthermore, treatments such as phototherapy can influence both the biochemical pathways and the physical integrity of the tissue, highlighting the complex relationship between biochemical interventions and biomechanical outcomes .