GPCRs also play a significant role in viruses other than Covid-19 such as influenza virus. For instance, a recent study discovered 19 proinfluenza GPCR genes in A549 cells of human lungs which were further tested in infected A549 cells. This process validated 16 proinfluenza GPCR genes. These results might help in developing host-directed therapies for influenza virus pandemic (Orr-Burks et al., 2021). Moreover, another study revealed that there is a strong association between the antibodies against the GPCRs and the renin angiotensin system molecules and symptoms of Covid-19 especially in autoimmune patients such as those with rheumatoid arthritis and systematic sclerosis. In a recent study, hierarchal clustering was utilized and it linked some autoantibodies to symptoms. For instance, CHRM5 and XCR3 were found to be associated to fever, CHRM5 and BDKRB1 with muscle ache, F2R and AGTR1 with that of anosmia and BDKRB1 and AGTR1 with that of dysgeusia. Moreover, it was also observed that the severity of the symptoms got increased upon rising AAB levels and anti-AGTR1 antibodies were found to be P a g e 14 | 56 as significant predictors. Beyond that, concentration dependent GC degradation was found to be mitigated by AGTR1 antagonist Losartan which proposes a potential therapeutic strategy for Covid-19 combat . GPCRs involved in viral infections along with their specific role in that infection and key mechanism are shown in Table : 1 below.