Additional SNAC then continued to aggregate around the membrane-anchored peptide, which began to slowly sink into the membrane after ~100 ns. Throughout the remainder of this unbiased simulation, semaglutide continued to sink into the membrane as more SNAC molecules enveloped the hydrophobic portions of the peptide (see Figs. , and Supplementary Movie 8). Based on these results, we hypothesize that -as semaglutide sinks through the SNAC membrane defects -there is a dynamic redistribution of the surrounding SNAC molecules. Specifically, SNACs located near the exterior of the membrane-bound defects are more dynamic than those in the interior of the defects (see Figs. 4C and Supplementary Figs. 24-27). This movement of mobile SNACs along the exterior of the dynamic defects gradually sinks the peptide into the membrane.