included simulations with no softcore atoms (No SC), simulations where only one oxygen atom was transformed into a sulfur atom (1 atom SC), and simulations where all atoms underwent softcore transformation (all SC). Specifically, at λ = 0, increasing the simulation timestep from 0.5 fs to 4 fs resulted in a noticeable increase in energy drift across all softcore scenarios. For the No SC case, the energy drift increased from 1.4 kcal/mol/ns to 3.9 kcal/mol/ns. When one oxygen atom was transformed (1 atom SC), the drift increased from 1.1 kcal/mol/ns to 4.2 kcal/mol/ns. Finally, with all atoms undergoing softcore transformation (all SC), the energy drift rose from 0.91 kcal/mol/ns to 3.0 kcal/mol/ns. These results clearly indicate that the energy drift is sensitive to the chosen timestep, even with different softcore implementations.