In conclusion the present work provides a new method for the preparation of isomaleimide through a 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (EDC) as a dehydrating agent The notable advantage of this methodology are mild condition, general applicability, lower reaction time, no column chromatography purification, high yields and no polluting reagents to be used. We believe this will serve as a useful addition to modern synthetic methods.