The utility of these reactions will likely extend beyond a medicinal chemistry setting as its simple and homogenous nature bodes well for large scale applications. To exemplify this, gramscale preparation of substrates 17 and 92 were performed by reacting sulfonyl hydrazide 8 with aryl bromide 93 and RAE 91, respectively, in good yields. The clear advantage of eliminating exogenous redox in radical cross-coupling reach beyond reaction simplicity (no need for e-chem or photochem setups or expensive sensitizers), it can also facilitate transformations that are difficult to scale up or unworkable. For instance, as illustrated in Figure , 1,4-trans substituted cyclohexanes 96 and 100 can be easily accessed in "dump-and-stir" homogenous reactions using sulfonyl hydrazide donor 94a with arenes 95 and 99, respectively (reactions run one time with no optimization). In the former case, an inconvenient flow photochemical scale-up is required for decarboxylative coupling and in the latter case the reaction did not proceed, necessitating a laborious workaround .