Separately, mechanochemistry has rapidly evolved to become a robust and time-efficient tool for conducting a wide range of ground-state reactions. While many solution-state reactions require an inert atmosphere to function, mechanochemical reactions usually do not. Thus, mechanochemistry reactions can often be simpler to set up, faster, and produce much less solvent waste. While mechanochemistry is readily amenable to two-electron ground-state chemistry, single-electron transfer mechanochemistry is more difficult to achieve without using reactive zero-valent metals, or via mechanoredox chemistry. For instance, Ito and co-workers recently reported a metallaphotoredox-like aryl amination reaction using BaTiO3; 61 however, due to the relatively small redox windows of current piezoelectric materials, and without the capacity to access PEnT reactions, this approach is potentially limited in terms of the range of substrates, particularly when compared to the versatility offered by photocatalytic methodologies. In efforts to address this limitation, several groups have attempted to combine mechanochemistry and photochemistry within a single reactor. Recently, we advanced the general utility of mechanophotocatalysis, a methodology wherein photocatalysis is conducted in a modified ball-mill reactor, across a mechanistically diverse range of simple photoredox and energy transfer solution-state photocatalysis reactions. We demonstrated that PET and PEnT air-sensitive solution-state photocatalysis reactions can be conducted under aerobic conditions, in the absence of bulk solvent, and that frequently the yields are comparable or even superior to the solution-state photocatalysis. Here, we report the first examples of mechanometallaphotoredox catalysis reactions; achieving aryl aminations, C(sp 2 )-C(sp 3 ) cross-couplings with oxidatively generated radicals, and a XAT mediated cross-electrophile coupling, under solvent-minimized aerobic conditions, with competitive efficiencies to the solution-state analogues, Figure , addressing some of the greatest limitations with this valuable synthetic methodology.