A good drug candidate should not only have effective efficacy against the therapeutic target, but also show teeming ADME properties at a therapeutic dose . The predictive human colon adenocarcinoma cell lines (Caco-2) in-vivo drug permeability values of all the compounds range between -5.01 log cm/s for compound 13d and -4.77 log cm/s for compounds 16b and 11e respectively, which were greater than -5.15 log cm/s earmarked for compounds with proper Caco-2 in-vivo drug permeability. This indicates that all the selected hybrids would be permeable in-vivo according to the results in Table . All the selected hybrids all the selected hybrids may be metabolized by P-glycoproteins, exception is for compound 13b which indicated moderate affinity as P-gp substrate. P-gp is thought to act as a barrier to intestinal drug absorption because it is found in large quantities on the villus tip of enterocytes' apical membrane, where it extrudes substrate from inside the cell back into the intestine's lumen. The role of P-gp in drug absorption has been demonstrated in a variety of preclinical investigations employing in-vitro cellular systems and MDR1 knockout mice that lack ABCB1 and thus do not express P-gp .