The most spherical morphology was obtained with the following parameters: 1.20 g, 1.5 mL/min, 50 °C, and calcination. However, greater adsorption efficiency was observed in the non-calcined version due to higher values in surface area, pore size, and pore volume, with an increase in efficiency of 79.14% for H9-EN with the modification of the molar ratio 1:10 artemisinin/hydroxyapatite. A controlled release between 20 and 1560 min was satisfactorily obtained for H9-EN, adjusted to the Higuchi kinetic model.