To evaluate the effect of compaction pressure and obtain structural information on the degree of polymorphic transformation in glycolide tablets, we compressed 20 tablets to pressures ranging from 47 to 548 MPa. Blended powders were weighed and manually loaded into the die to compress the tablets to target pressures of 50, 100, 130, 150, 170, 200, 300, 400 and 548 MPa (see section S1.4 of supporting information). The weight of the tablet was altered to ensure that the tablet thickness was constant while varying the compaction pressure. Flat-faced round steel punches (diameter: 5 mm) were used to compress the powder over a 1 s period using a uniaxial compression profile. The tablets were prepared 4 days in advance of characterization on beamline P07 at DESY synchrotron. Between preparation and characterization, the tablets were stored in a sealed container at 5°C ± 2°C and 65% ± 5% relative humidity. The tablets underwent full relaxation before being studied.