Before discussing the mechanisms by which peptides target biofilms, it is important to distinguish between Anti-biofilm Peptides (ABPs) and Biofilm Inhibiting Peptides (BIPs), as well as the measures used to assess their effectiveness: Minimum Biofilm Inhibitory Concentration (MBIC) and Minimum Biofilm Eradication Concentration (MBEC) . MBIC indicates a peptide's efficacy in preventing biofilm formation , largely independent of its ability to penetrate the extracellular matrix, making it a suitable metric for BIPs. Conversely, MBEC evaluates a peptide's efficacy against pre-formed biofilms , where activity likely depends on the peptide's capacity to reach bacterial cells within the dense ECM. MBEC is thus the appropriate measure for ABPs.