The MOFs generally demonstrated stability under basic conditions as all MOFs were stable at a pH of at least 11 or higher with SU-112 being the least stable, while SU-103, SU-105, and SU-108 were robust even at a pH of 13. Acid stability was more varied as some MOFs had degraded at a pH of 2 (SU-105, SU-106, SU-109 and SU-112), while others demonstrated even higher stability than SU-102 at a pH of 1 (SU-103, SU-104, SU-108 and SU-110). The MOFs also were stable the selected organic solvents. It should be noted however that for the layered structure SU-110 with the most hydrophobic OSDA, trioctylammonium, peaks in the PXRD pattern remained but were severely broadened when exposed to nonpolar solvents (hexane, THF and toluene). Most MOFs were also stable in 1M NaCl and 1M KCl solution with the exceptions of SU-107 and SU-112, although it should be noted that the MOFs with more hydrophobic OSDAs including SU-104, SU-109 and SU-110 with trialkylammonium OSDAs only showed very limited ion exchange. All MOFs are stable to water at room temperature, while only SU-112 degrades at 80 °C, and SU-103, SU-104 and SU-108 were fully stable under hydrothermal conditions at 180 °C.