A visual representation of the chemical space of the compounds and fragment libraries was conducted with (t-SNE) and PCA. As detailed in the Methods, we used multiple descriptors for a more comprehensive analysis of the chemical space, i.e., chemical multiverse analysis. The visual representations were based on t-SNE and PCA of similarity matrices of the pairwise comparisons of the similarity computed with the Tanimoto coefficient and three fingerprints. Two similarity matrices were generated, one with 5724 dimensions (Figure and Figure ) (compounds) and the second with 27395 dimensions (Figure and