To generate the initial all-atom coordinates, 20 disaccharides were randomly inserted into a cubic box with dimensions (61.45 x 61.45 x 61.45) Å 3 containing 7609 water molecules. The resulting all-atom disaccharide structures were mapped into the corresponding coarse-grained representation using our previously reported PyCGTool methodology to set-up the starting configurations for the coarse-grained simulations. Each of the coarse-grained disaccharide systems was then solvated via the insertion of 1902 water beads. The aforementioned "soft" equilibration protocol was used for the systems containing the 2MA_0MA, 4MA_0MA and 6MB_0MB disaccharides, with the remaining disaccharides treated using the simple protocol described previously. The final AA trajectories were then mapped into pseudo-CG trajectories using PyCGTool in order to standardize analysis across the two regimes.