One approach for extracting and transporting such highly hydrated anions is using compounds which can form multiple Hbonds with the anion. 14, Strapped calix [4]pyrroles developed by the Sessler, Gale, and Ballester 20 laboratories have emerged as efficient anion carriers, with their selectivity and transport activity depending on the functionalisation of the calix [4]pyrrole scaffold and the nature of the "strap". While there are reports on the encapsulation of phosphates with these synthetic receptors, 26,27 no transport of H2PO4 -has been reported to date. Herein we report the first example of inorganic phosphate transport, using novel anion receptor 1. The receptor design is based on two anion binding motifs: a calix [4]pyrrole and an orthophenylenebisurea strap, each providing 4 H-bond donors (Figure ). The benzylic linkers act as relatively rigid spacers, fixing the two binding motifs at a distance which should enable the cooperative binding of phosphate, but also ensuring the efficient shielding of its charge from the hydrophobic membrane during transport. The transport of phosphate into liposomes by receptor 1 and the corresponding control compounds 2 and 3 (Figure ) was studied by two assays, the first exploiting the emission properties of an encapsulated phosphate-sensitive Eu 3+ probe, and the second using 31 P NMR spectroscopy.