Potential Matching (LJSPM). With this method, one can directly derive the LJ parameters for estimating the vdW interaction of pairwise CG particles using static structures and AA force field information. The advantage of the LJSPM method lies in that it has explicit analytical expressions for coarse-graining, which allow the derivation of LJ parameters without the need for time-consuming AA dynamic samplings or laborious parameter procedures. The LJ parameters obtained via LJSPM have clear physical meanings and satisfy the Lorentz-Berthelot combining rules when computing LJ interactions. We have employed LJSPM to construct the CG models of DPPC lipids, and the subsequent CG-MD simulations successfully reproduced its selfassembly process. The thermodynamic data such as free energies and enthalpies calculated from the CG-MD trajectories showed good agreement with the corresponding AA results.