The main conclusions are thus that the semiempirical methods are accurate and fast enough to automatically identify promising candidates for DFT refinement for the low barrier reactions of 3hydroperoxypropanal within 15-30 minutes using modest computational resources. The main question is how the systematic and meta-dynamics search algorithms scale with system size and whether the optimum hyperparameters found for this molecule also perform well for other types of reactions. We are currently investigating both questions and preliminary results suggest that the answer to the latter question is yes.