Rimantidine is known as one of the tighterbinding guests of βCD, with a measured dissociation constant of ~30 µM . Thus, it is of interest that TDZ with βCD comes close to this affinity (66 µM), and that TDZ with H26DM-βCD surpasses it (18 µM). Indeed, two of the TDZ complexes have binding free energies over 2 standard deviations better than the mean in an overview of CD-guest binding .