Continuous flow chemistry could be used to decouple these conflicting needs (Figure ). In this scenario, crystallization would be conducted in a typical vessel. Mother liquors would then be removed from the vessel by pumping through a filter. The stream containing the undesired enantiomer would be pumped through a high temperature unit to effect instant epimerization. Solution now enriched with the desired atropisomer would then return to the vessel for further crystallization. The recycle could be conducted essentially ad infinitum to achieve a theoretical yield of 100%. We refer to this continuous recycle with spatially discrete unit operations as a DKR mediated by simultaneous processing of antagonistic chemical events (continuous-SPACEDKR). This strategy has very recently been applied for select transformations.