One such study found that RANK, a protein of the tumor necrosis factor (TNF) superfamily secreted by immune cells, is a crucial receptor in bone remodeling . Mice lacking this receptor Figure : Several local and systemic cells and chemicals influence bone health, and their complex interactions can be explored via mathematical models of the bone remodeling process. Created with BioRender.com. Adapted from "Pie Chart 7X" by . Retrieved from .