It has been suggested that LNP organization depends not only on their lipid composition and cargo but also on pH of the environment. . LNPs containing siRNA or mRNA are proposed to have a multilamellar or inverse hexagonal / worm-like internal structure , respectively. The lamellar topology has been shown to only be maintained with charged MC3 (DUMP) based on SAXS (Small Angle X-ray Scattering) data . The following question is whether the same ILs can form an inverse hexagonal phase, given the right conditions, such as pH .