Hantavirus (HTNV) originated in bats, shrews, or moles and later established persistent infections in rodents . HTNV is a virus with an genome composed of three negative-sense RNA segments (L, M, S) . The segments L, S, and M of HTNV, respectively, encode RNA polymerase L, viral nucleocapsid protein N, and membrane glycoprotein M . CK II can phosphorylate HTNV N at threonine residues . N protects RNA from cellular nucleases and collaborates with L to guarantee that the viral genome replicates effectively . Segment M contains the glycoprotein precursor (GPC) sequence . Cell signal peptide complex cleaves GPC to form Gn and Gc at a conserved WAASA sequence . Peptides containing Gc residues interact with artificial membranes, preferably cholesterol and sphingomyelin-rich, and are typically found in lipid rafts . Gc residues are believed to be involved in the membrane contact . Once the proteolytic process is complete, Gn and Gc are individually anchored to the phospholipid membrane via their transmembrane domains, with their N-terminal domains pointed toward secretion the pathway's lumen .