Due to the fact that cancer is caused by varying underlying mutations in different genes, several cellular pathways are affected by its manifestation; this set of pathways is referred to as the hallmarks of cancer . The pathways include proliferative signaling, angiogenesis, evasion of growth suppressors, invasion and metastasis, resisting apoptosis, inflammation, genomic instability, and unlimited replication potential. Inhibition of one of these key pathways may still allow cancerous cells to survive and adapt to the administered drug therapy. The likelihood of drug resistance decreases when multiple pathways that are known to be relevant in cancer are targeted . There still needs to be a consideration of the role of the pathways targeted and their relationship between one another.