Metal-organic frameworks (MOFs) are comprised of periodic arrays of metal centers interconnected through organic ligands to form crystalline coordination networks. MOFs have great diversity and tunability in both their chemical and structural properties and have high surface areas, large pore structures as well as high thermal and chemical stability. As a result, MOFs are investigated for catalysis, gas storage, drug delivery and energy storage. Post-synthetic modification methods, such as pyrolysis or calcination, produce MOF-derived catalysts which are capable of outperforming conventional catalysts. These high temperature processes create amorphous structures and complex heterogeneous chemical environments only accessible through thermal decomposition. The atomic structure of these materials are not well understood. Standard structural characterization methods cannot give exact information about the atomic arrangement within amorphous MOFs. Consequently, there is limited understanding of a structure-property relationship between the initial MOF and the resulting catalytically active pyrolysis product.