Since benzothiazoles are one of the best-known heterocycles, there are dozens of reviews devoted to their synthesis, including the most recent . Despite this, photochemical methods for their synthesis are relatively rare and are not systematically presented in these and similar reviews. Thus, this comprehensive review highlights the 15-years progress in the synthesis of benzothiazoles mediated by visible light providing overview of their synthetic scope. This work is structured based on the type of starting compounds used for the synthesis of benzothiazoles. In addition, the possible mechanisms of transformations are discussed. The thiazole heterocycle itself is certainly a privileged structure and ranks 12 th on the list of heterocyclic moieties most frequently found among FDA-approved drugs in 2013-2023 . It is, therefore, not surprising that the wide range of pharmacological activities exhibited by benzothiazoles highlights their potential as key compounds for future drug development. Recently, research on benzothiazole-based medicinal chemistry has become a rapidly evolving and increasingly active subject. In particular, many benzothiazole-based compounds as clinical drugs have been widely used in practice to treat various types of diseases with high therapeutic efficacy (Fig. ). Among them anticancer , anti-inflammatory , antimicrobial , antifungal , anticonvulsant , antimalarial , antiviral , antidiabetic , antihelmintic agents. In addition to their application in different morbid conditions, they were also reported as inhibitors of such enzymes as α-glucosidase, carbonic anhydrase, acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE), topoisomerase I and II, p38α-MAP kinase, β-glucuronidase, cytochrome P450 etc. .