To validate the performance of OLIVES we prepared a series of coarse-grained simulations for comparison to the atomistic simulations. For each of the 4 test systems, we created 8 coarsegrained systems: OLIVES (with and without quaternary contacts in the protein complex), OLIVES + DSSP (with secondary structure restraints and with and without quaternary contacts in the protein complex), GoMARTINI (with and without quaternary contacts in 13 the protein complex), GoMARTINI + DSSP (with secondary structure restraints and with and without quaternary contacts in the protein complex).