To discriminate the error of force field parameters from sampling errors, the set of all edges was filtered according to two convergence criteria indicating issues with sampling. The first criterion is the convergence criterion α based on the overlap of the work distributions from the non-equilibrium sampling. α is -1 ≤ α ≤ 1 and is described in more detail in reference 67, Equation . The second criterion is the standard deviation of the ∆∆G values σ(∆∆G)