Although information technology and DS are now widespread, chemists have been using computers and computer science to solve chemistry problems for decades. In the early 1960s, the Chemical Abstract Service developed an algorithm to generate a unique machine descriptor for chemical structures . This algorithm has inspired other algorithms and standards, such as SMILES , SYBYL , and InChI . Moreover, organic chemists have developed expert systems for chemical structure elucidation and organic synthesis planning . Therefore, chemists have been using computers and algorithms for a long time, and their growing interest in ML and DS is natural. Thus, this review will briefly discuss the state-of-the-art DS and ML applications in chemistry and provide a perspective on how they can change organic chemistry in the following years