Recently, a simple approach for including electronic polarization in a mean-field way in classical non-polarizable force fields has been suggested. Within this method, denoted as the electronic continuum correction (ECC), electronic polarization effects are accounted for by scaling the charged groups by the inverse square root of the high-frequency dielectric constant of the surrounding medium, i.e., by the inverse of its refractive index. Note that the high-frequency dielectric constants of the relevant biomembrane distinct environmentsaqueous solutions, membranes, and protein interiors-have values around 2, being very similar to each other (unlike the total dielectric constants), which renders this essentially continuous approach applicable. In principle, charge scaling should be equivalent to immersing the whole system into a dielectric continuum with a dielectric constant of about 2. However, since our charge scaling is based on previously parameterized non-polarizable force fields, it has turned out to be prudent to scale only the charges of ions and ionic groups and not, e.g., of polar molecules like water. In other words, some degree of charge scaling may have been already included implicitly in the original force field when fitting it to experimental data. Note that partial charges are not experimental observables and, therefore, their values depend to some extent on the particular procedure adopted for their derivation. Also, the dielectric properties of common water models may not be entirely consistent with the ECC approach in the sense that their dielectric constants are larger than the experimental lowfrequency value. Therefore, scaling factors lying anywhere between the inverse square root of the high-frequency dielectric constant and unity have been suggested. In the context of phospholipid membrane modelling, one of the key experimental manifestations of the deficiency of standard non-polarizable force fields is the grossly overestimated binding of biologically important cations such as sodium and calcium to lipid headgroups.