Hypertension and dyslipidemia are the most commonly reported comorbidities. These results are of particular interest considering the debate related to the protective role of hypertension and other cardiovascular disorders for the prognosis and survival of ALS. The occurrence of autoimmune diseases in ALS patients is frequently reported, but little is known about the related clinical phenotype. Association of ALS and cancer (overall cancer, as well as certain specific cancers) has been examined, and the results have been ambiguous and inconsistent regarding the risk of cancer in general, and of specific cancers. A study examined cooccurrences of ALS and multiple sclerosis, both associated with upper motor neuron degeneration, checking the possibility for common biological pathways. The study concluded though that rather than a shared biology, the co-occurrences are random, although a common risk factor cannot be excluded.