The parameter IL/IR, representing the ratio of left-handed to right-handed CPL, becomes a chiral ratiometric factor of 1.0021 in MeOH or 1.0032 in H2O. This new provides a quantitative measure of the chiral properties of the fluorophore polymer chemosensors. In conclusion, this study reports the discovery of ratiometric response polymer chemosensors induced by hydrostatic pressure, representing a novel approach in the field of "mechano" science. These findings provide a pre-cise method for detecting hydrostatic pressures and offer advantages in terms of sensitive and selective signal readout. The use of pressure-responsive polymer chemosensors, especially in a ratiometric manner, holds great promise for various applications. Hence, this study provides guidelines for designing smart polymer materials with ratiometric responses to hydrostatic pressure and notable CPL performance, facilitating the development of advanced multifunctional polymer materials.