Applying the Shapiro-Wilks test of normality to the rpoB data confirms that, despite the small numbers of samples in some cases, the majority of DG values are indeed normally distributed with the exceptions of DG qon for the apo leg of S428C and DG qon for the drug bound leg of S450L. For two DNA gyrase mutations there was also evidence of non-normality in the DG vdW for the apo leg of gyrA S95T and DG on for both the apo and drug bound leg of gyrA D94G.