Our design of azobenzene-thapsigargin conjugates, termed AzTGs, was motivated by the notion that TG can be seen as a lipidated terpene that bears four acyl chains. In addition, an X-ray structure was available that showed the position of the various acyl side chains in the SERCA-inhibiter complex. In combination with synthetic accessibility considerations, we decided to mount azobenzene containing fatty acids onto the secondary hydroxy group in position 8 of the seven-membered ring. Photoswitchable fatty acids have proven to be powerful control elements in a variety of glycerophospholipids, sphingolipids, and vanillamides and used for the optical control of G-protein coupled receptors and ion channels. This gave rise to TG derivatives AzTG-2, AzTG-4 and AzTG-6, wherein the azobenzene switch is increasingly distal to the tricyclic core. The UV-vis spectrum of AzTG-2 is depicted in Figure to highlight the changes in the absorption spectrum between the dark-adapted state and photoswitching with UV and blue light.