Global docking offers several advantages in molecular docking by exploring all potential binding sites on a target protein. This comprehensive approach ensures that no potential binding region is overlooked, providing a complete understanding of possible ligand interactions. One significant advantage is its utility in predicting side effects, as it examines every cavity on the target protein, identifying off-target binding sites that might lead to adverse impacts. The therapeutic effect or side-effect of a ligand depends on where and how it binds to a target ( ). Any cavity on a target may be a reason for side effects. Therefore, cavities should be considered to predict side effects ( ). These requirements make global docking more suitable to investigate side effects. A unique consensus-global docking method can destroy the limitations of global dockings, such as high false-positive and low accuracy ( ). Despite the advantages of global docking programs, they have been plagued by lower performance than local docking methods.