3b. Water Analysis. The electrofreezing of water has been reported previously in the literature using the tip4p and six site water model, as outlined in the introduction. In the work of Yan et al. for example, it was observed that electric field intensities between 1-2 V/nm could induce the electrofreezing of the six-site water model within 50 ns at 270 K . The electrofreezing of water was attributed to the near 40 K elevated melting temperatures of ice Ic crystals, relative to the no field 289 K melting temperature, due to near perfect alignment with the applied electric field vector . In this work however, the SPC/E water model is employed to accurately reproduce the enthalpy of solvation of glycine in water , as outlined in section 2a. In contrast to the 289 K melting temperature of the six-site water model, the melting temperature of SPC/E water is only 215 K in the absence of any dissolved solute . Previous observations by Svishchev and Kusalik demonstrated that pure SPC/e water did not undergo electrofreezing, even with electric field strengths as large a 5 V/nm . These facts make it highly unlikely that the lower electric field intensities (0.6 V/nm), higher temperatures (330 K), and dissolved solute (glycine), used in this work could facilitate electrofreezing. However, this must be confirmed quantitatively.