However, recently, static X-HCFF calculations and AIMD simulations have demonstrated that hydrostatic pressure can be used for this task. In the iconic spiropyran (SP) mechanophore, the force-induced rupture of the central carbon-oxygen bond, which yields merocyanine (MC), can be reverted by hydrostatic pressure in the range of a few GPa (Figure ). In this process, MC acts as a "piezophore" that responds to pressure by bond formation. As in many pressure-induced chemical reac-