In summary, we have developed a highly stereospecific cyclization of aziridine silanols into 1'-amino-tetrahydrofurans. Our protocol of stirring substrate with 10 mol% of Sc(OTf)3 and 1 equivalent of NaHCO3 in CH2Cl2 is mild and compatible with a range of activating aziridine N-substituents and functional groups on the alkyl chains. In all cases examined, trans di-substituted aziridine silanols give products with an erythro configuration; conversely, cis di-substituted aziridine silanols give products with a threo configuration. Control experiments demonstrate that, for this transformation, the silanol is not particularly privileged, and a variety of protecting groups on the alcohol are compatible for product formation. Given the ubiquity of 1'-amino-tetrahydrofurans in targets of medicinal value, we expect this protocol to be a valuable addition to the synthetic armory.