The method applied in this work to create surfaces-and gradient-controlled PECs can be logically extended to other compositions of polyelectrolytes. Continuous perturbation of acid-base equilibria based on various PEs, in particular, could reveal how temporal signals of other, more, biologically relevant processes can be modulated using the amplitude, frequency, and duration of an input signal under out-of-equilibrium conditions. We fully expect that the modular means of our setup offers ample opportunities to exploit properties that favors polyelectrolyte-based systems for the design of surfacedriven CRNs. Beyond, the simple means by which their complexation can be examined in flow could impact a wide-range of studies from exploring concepts in the origin of life to developing smart materials.