For this pilot study, we selected 17 diverse, non-metal-or co-factor-containing protein targets from the DEKOIS2.0 library 46 , which contains relatively small and homogeneous in size sets, featuring 40 bioactives and 1200 decoys per target (Table ). In DEKOIS 2.0 the bioactives have been chosen to represent the diversity of the bioactive chemical space for each target, trying to avoid unnecessary redundancies.