Table compares the residence times obtained from τRAMD simulations for the agonist 1 and antagonists 2-6. The differences among the residence times are statistically significant (one-way ANOVA, p-value: 4.2e-38). The agonist 1 displayed on average a longer residence time, 40.0 ns, while the antagonists 2-6 displayed an average residence time of 4.5 -14.3 ns. A possible reason for the agonist's longer residence time can be its unbinding via the external path only. Moreover, neutral antagonists were able to unbind via both pathways. The presence of two possible unbinding paths, instead of one, likely contributed to the reduced residence times for neutral antagonists, in comparison to the agonist.