Community feedback has been and will continue to be valuable to help improve the design and features of future versions, potentially including the addition of new sections or substantial revision to existing sections where this is justified. The addition of the annotation content breakdowns to the regulatory collection was based on many questions from users about how to find the most relevant PFAS entries. As this annotation content is also available in the download files, it is possible to retrieve this information for any subset of the PubChem PFAS Tree. However, since the annotation data in PubChem is compiled from publicly available data and user contributions, it is not completely exhaustive. In other words, the presence of "Use and Manufacturing" information for a PFAS implies that this information is available in PubChem for that chemical with a suitable reference, but this does not imply that the entire "Use and Manufacturing" section covers all known uses. The PubChem PFAS Tree has been available for over a year (since March 2022), was the subject of several presentations and webinars and has already been used in published research . Contributions of new PFAS or fluorinated chemicals and/or related annotation content, as well as feedback and suggestions about how the PubChem PFAS Tree can help the PFAS community answer their pressing questions are very welcome.