One example of an enhanced sampling approach is a hybrid simulation approach which combines non-equilibrium candidate Monte Carlo (NCMC) move proposals with traditional MD simulations. We previously implemented this NCMC+MD approach in a software package called BLUES: Binding modes of Ligands Using Enhanced Sampling, which aims to accelerate sampling of ligand binding modes by proposing random rotational moves on the ligand and then runs a conventional MD simulation. BLUES is similar to using traditional Monte Carlo (MC) moves with MD, except that it uses a gradual non-equilibrium based switching protocol while performing perturbations to the ligand instead of an instantaneous perturbation. In theory, this allows us to perform larger perturbations to the ligand and increase acceptance of proposed moves over traditional MC. With the BLUES approach, we hypothesize that we will observe better sampling of ligand binding modes and be able to identify the experimental ligand binding modes over using traditional MD simulations.