Mangiferin show effective inhibitory activity at 50 μM concentration that has been shown antidiabetic action by inhibiting Protein tyrosine phosphatase 1B (PTP1B) in table 1. Compound 6 and 9 shown 100% and 62.5% inhibition against PTP1B. bath. The reaction mixture further processed by washing and extracted then purified by column chromatography using petroleum ether : chloroform : acetone (10 : 7 : 3) as eluent to give desired compounds HBM.