While the results for benzene are undoubtedly an impressive first result, it is worth noting that the interactions in crystalline benzene are mostly weak dispersion interactions, and thus low energy barriers are expected. By contrast, modern organic CSP targets typically have a range of interactions of different strengths, including notably hydrogen bonds. Indeed, finding transitions between hydrogen bonding motifs has been a challenge for MD based methods since these generally tend towards sampling transitions via the weakest interactions. Consequently, connections are found largely between structures with the same hydrogen bonding motif. Monte Carlo methods are less inhibited in this regard due to the sampling not being directed by the gradient of the energy surface, and we see this as a potential advantage of threshold clustering.