In a recent paper, Chang synthesized ten principles from SM and listed them as: definition, generalization, induction, elenchus, hypothesis elimination, maieutics, dialectic, recollection, irony, and analogy (Table ). The ten Socratic principles provide a structured framework for inquiry, offering methods to clarify concepts, challenge assumptions, and refine hypotheses. These approaches foster critical thinking, systematic exploration, and creativity, making them a powerful tool for leveraging LLMs in addressing complex challenges in chemistry, such as hypothesis generation and ambiguity resolution in reaction mechanisms. By integrating these principles into prompt engineering, researchers can design prompts that enhance critical thinking, creativity, and depth in interactions with LLMs. In the following subsections, we explore how each principle can guide prompt construction and contribute to solving specific challenges in chemistry research and discovery.