The scaffold content analysis was based on the definition of Bemis and Murcko, which considers a scaffold as the rings in a molecule and the connectors of them, the analysis was performed using an inhouse code in Python with the modules MurckoScaffold of RDKit library. Also, the chemical structures of the compound database were analyzed using well-established protocols and broadly used to characterize or assess the chemical diversity, namely scaffold contents and structural diversity using four molecular fingerprints: Molecular ACCEs System (MACCS) Keys (166-bits); Extended Connectivity Fingerprints (ECFP) radius 2 and 3; and RDKit fingerprints. The similarity analysis was calculated using the Jaccard-Tanimoto index.