To gain entry to the host cell, a critical first step in any virus replication cycle is attachment to the host cell's surface, which in many respiratory viruses is mediated by viral surface glycoproteins . Viral entry strategies can broadly be classified as occurring through direct fusion or receptormediated endocytosis, with viral surface glycoproteins playing a critical role in both . The next stage of viral replication is expression of the viral genome and the generation of new viral particles through the exploitation of host translation machinery. This includes the biosynthetic secretory pathway through the endoplasmic reticulum (ER) where proteins can undergo glycoylation .