Overall, several interesting hits were discovered using our community effort. Whereas consensus scoring has long been established in docking methods , extending it to other computational methods had not previously been considered. The discovered compounds have micromolar affinities, thus requiring further hit-to-lead development. Overall, the most potent compound Nsp5-3 found has an IC 50 = 9.41 µM (95% CI is 5.32-19.27) in live cell assays, but with significant cytotoxicity that would need to be further addressed. The most prominent family was the benzotriazolyl acetamide family (Figure , Nsp5 dashed box), which has been found in other studies likely because several teams used ML methods starting from similar training sets, combined with the fact that benzotriazoles in general can easily be synthesized using 'click chemistry' , which is high-yielding and fast, and thus preferred by the CRO that performed the chemical synthesis. In addition, the CRO performed a proprietary synthetic feasibility and ADME screening that introduced a bias in the number of compounds that were eventually synthesized for each individual team.