The first step towards the generation of a brute-force docking baseline was the preparation of ligand 3D structures from the original 1.56 billion input SMILES. Relevant tautomers and stereoisomers increased the library size to approx. 3.8 billion structures, which we distributed in 781 ligand databases for parallel docking. Preparation of this screening library took around 30 days (457 600 CPU hours) when utilizing 640 CPUs on the CSC Mahti supercomputer.