The optimal short-range cutoff distance and order of the multipole expansion varies de-pending on the system. Our results indicate that a relatively short cutoff can be applied for homogeneous systems (e.g. solute-solvent systems) while for heterogeneous systems (e.g. proteins) it may be necessary to use longer cutoffs. The number of atoms in the QM subsystem can be used as a guideline to decide at which order to truncate the multipole expansion, e.g. higher number of atoms generally require higher orders of multipoles. In general, it is advisable to investigate which cutoff distance and multipole order is suitable to achieve a desired accuracy.