Mutation sites G75V, T76I of the SARS-COV-2 C.37/lambda variant are both in the MHC_II_beta A domain. So S 62-80 of SARS-COV-2 alpha, beta, lambda variants were the first MHC-like enhanced distribution area. The second MHC-like enhanced distribution area of S protein is 127-194, located in the N-terminal domain (14-305 residues) of S1 protein. MHCassoc_trimer (144-162) is a trimer of S Formation, which plays an important role. The third and fourth MHC-like enhanced distribution areas of S protein are MHC_I-like_Ag-recog E (616-676), MHC_I-like_Ag-recog G (1014-1114).