The solvation energy is partitioned into electrostatic and non-electrostatic components, including cavity, dispersion, and solvent contributions, as presented in Table . We can see that the coupling energies in our hybrid model, which represent the electrostatic energies, are comparable to the dielectric energies in the SMD model and our cavitation-disperionsolvent contributions are in the same order of magnitude as those from the SMD. Our hybrid model offers the ability to separately examine which specific component drives the solvation process. For the polar molecules (e.g., methanol and water) and ions (e.g., ammonium, chloride, and sulfate), the electrostatic interaction dominates the solvation energy while for the non-polar molecules (e.g., methane and ethene), the non-electrostatic cavity-dispersionsolvent interaction is the main contribution in the solvation energy.