In summary, a convenient approach for constructing fused seven-membered polycyclic architectures widely found in natural products and small molecule drugs was developed. This synthetic protocol proceeded with the merits of mild conditions, broad substrate scope, operation simplicity, and excellent regioselectivity. Based on this method, we accomplished the total syntheses of plecarpenene and plecarpenone in an extraordinarily efficient manner. To further demonstrate the applicability of this method, the key core of the echinopine natural products was successfully assembled. Further studies to expand the reaction patterns and the applications in synthesizing complex natural products and other bioactive molecules are still ongoing in our laboratory.