The equation ( ) can be directly used to calculate the feasibility and extent of a reaction using the acid/base constants of individual components. For example, if pKa,HA < pKa,HB, then the value of ∆𝐺 -."/(00 1 will be negative, and hence HA will transfer a proton to the B ¯ to drive the reaction forward. The magnitude of ∆𝐺 -."/(00