1. **Elucidation of the Biosynthetic Pathway**: -The paper uncovers the biosynthetic pathways for tri-and tetra-oxygenated taxoids, which were previously unclear. The work clarifies critical reaction sequences, including the second and third hydroxylation steps in the biosynthesis of these oxygenated intermediates. -The study identifies the enzyme taxoid 9α-hydroxylase (CYP725A37), which catalyzes the fourth hydroxylation step, leading to the formation of tetra-oxygenated taxoid intermediates such as 9,10-deacetyltaxusin .