The AICP reaction knowledge graph is comprised of reactions originating in the USPTO and a SAVI data sets, as described above. Analysis revealed that the knowledge graph contains multiple occurrences of many reactions. To investigate the expected negative effects of having duplicate reactions, we compared the performance of the more performant SP query on the original and the deduplicated databases. To isolate the effect of deduplication, the original database was compared to the +/+, deduplicated database, and only the execution time of the Cypher query (identifying the synthesis graph) was observed. The search depth of the queries were varied in the range of 1-3 reaction steps. The timeout of running the queries was set to 5 min. However, none of the queries ran beyond this time limit. There are a total of 14,179 unique multiproduct and 6,189 unique ambiguous reactions comprising 0.5% and 1.14% of the de-duplicated database (see Table ), respectively. There is some overlap between the multiproduct and ambiguous reaction sets, 4,186 reactions are both multiproduct and ambiguous comprising 0.39% of the de-depluicated database. As it can be seen in Figure , the removal of reaction duplicates seems to improve the query time. Based on the results, we decided to use the deduplicated +/+ database as baseline in further investigations.