The graph shows that the charge-charge interaction between the protein and the ligand is initially strong, but it decreases over time. This is because the protein and the ligand are initially in a high-energy state. As the protein and the ligand relax to a lower-energy state, the charge-charge interaction decreases The graph shows that the temperature fluctuates over time, but it generally decreases over time. This is because the system is initially in a high-energy state, and the atoms collide with each other, exchanging energy and relaxing to a lower-energy state.