For docking the selected compounds, we used the crystal structure of SARS-CoV-2 NSP15 endoribonuclease (PDB ID: 6WXC), which was imported into MOE. After the structure preparation and the model's binding pocket was defined, based on known key residues for its nuclease activity and uridine specificity, ligand conformations were generated using the bond rotation method. These were then docked into the site with the Triangle Matcher method and ranked with the London dG scoring function. The retain option specifies the number of poses (30) to pass to the refinement, which is for energy minimization in the pocket, before rescoring with the Induced Fit method and GBVI/WSA dG scoring function. To validate docking, 56 random control compounds were selected from the FDA drug database, using a random number generator without repetitions.