Metal-organic frameworks (MOFs), known for their highly ordered structures and exceptional versatility, have been investigated as key materials in a wide array of biomedical applications. Their unique properties featuring tuneable pore sizes, high surface areas, and inherent stability, makes MOFs ideal candidates for innovative solutions this area. The frameworks have been previously used as carriers for the delivery of DNA and proteins, where the tuneable pore size of the MOFs allows for the loading of high dosage, while their inherent stability ensures that the payload is released in a controlled manner. MOFs have been used as high sensitivity biosensors, with high surface area playing a key role in providing extensive binding sites for the immobilization of analytes. Concomitantly, giant unilamellar vesicles (GUVs) are very popular cell models. These sizable liposomes are important for studying membrane biophysics, interactions between membrane molecules, anion transport, and drug delivery for advanced therapeutics. Studies have reported MOF liposome assemblies that include but are not limited to the use of lipidcoated MOF nanoparticles, liposomes encapsulated in MOFs, MOFs embedded in lipid membranes of liposomes, and the use of MOFs with lipid functionalized surfaces. In recent literature, water-stable functionalized Hf and Zr MOFs embedded within liposome bilayer demonstrated the potential of sustainable energy production by facilitating photocatalytic splitting of water into H2 and O2 by sunlight irradiation. The lipid membrane efficiently separated the oxidative and reductive components of the system for charge separation. The stabilization of integrated MOFs within the liposome membrane may be largely dependent on the interaction between the embedded framework and the phosphate groups of the membrane that likely influence the photocatalytic water splitting performance of MOFs. In another study, MIL-100(Fe) MOF nanoparticles encapsulated in 1,2dioleoyl-sn-glycero-3-phosphocholine (DOPC) liposomes induced cell death by releasing high amount of Fe 3+ ions in the cells depending upon the acidification of extracellular pH. The phospholipid coating facilitated the uptake of MOFs by endocytosis which resulted in an effective strategy against cancer cells. Thus, despite growing interest in biomedical applications of MOFs, there currently is a lack of understanding of the chemical interaction of the MOFs with phospholipids. Specifically, the binding of MOFs to phospholipids, a key component of cell membranes, is not well studied. This knowledge gap hinders the development of intricate MOFbased hybrid systems that can mimic nature's machinery and effectively intermingle with and target specific cells.