Gas turbines have wide applications in power generation and aerospace industries, which operate at very high temperatures. Following the efficiency, as defined in the Carnot cycle, the efficiency of a turbine can be increased by increasing the operating temperature , which demands the use of alloys with higher strength levels relative to that used currently. At present, Ni-based superalloys are used in turbines which can operate up to 1100 o C. Therefore, there is a need to design turbine materials that can withstand temperatures > 1100 o C to realize further improvement in turbine efficiency. Refractory alloys based on Nb, W, and Mo have the potential for high-temperature applications because of their exceptional properties at elevated temperatures. Among these, niobium is a promising candidate as a turbine material due to its high melting point, low density, high room temperature ductility, and low ductile to brittle temperature . High-temperature, high-strength Nb-based alloys can be realized by adding suitable alloying elements which can provide a solid solution, dispersion, and multiphase strengthening, as well known in the physical metallurgy of refractory alloys . However, these alloying elements yield a huge compositional design space. Suppose we have fourteen alloying elements, excluding the base element niobium, and each alloying element's composition varies from 1 weight percent to 20 weight percent with a step size of 1 weight percent. In that case, the total number of possible alloy combinations can be expressed as: 𝐶