Additionally, to visualize the annotations and the reported chemical space at the individual molecular structure level, both, were structured using a TMAP visualization . The TMAP forms a minimum spanning tree built to link similar chemical structures using the MAP4 (MinHashed Atom-Pair fingerprint up to 4 bonds) fingerprint . In the diagram of Figure , each dot represents a chemical structure and is connected to its neighboring dot based on its structural proximity. The color code illustrates the distribution of chemical structures, with green representing the compounds reported in the Celastraceae family (occurring at least once), and red indicating structures annotated in the Celastraceae set. The putative structural annotations are well distributed along the tree, indicating that the set presented here covers a very large part of the chemical space reported for this family so far.