We can then proceed to another classic paper by Williams et al. , where the tight-binding of version of Cha's integrated rate Eqn (1) was first derived as Eqn (4). The authors state very clearly at the beginning of section Theory and Data Analysis that their newly derived rate Eqn (4) applies only to Mechanism A. They also add the following comment: "A more complex mechanism which predicts the slow development of inhibition is Mechanism B [...]. In this model an enzyme-inhibitor (EI) complex, which is formed rapidly, undergoes a slow isomerization to a second (EI*) complex. Attempts to derive an integrated equation for Mechanism B, analogous to Eqn (4), were unsuccessful [...] [T]he attempted solution leads to hopelessly complex algebra and an alternative technique must be sought. For particular values of the various parameters, the equations may be solved by numerical integration." Williams et al. essentially state that they attempted but failed to derive a closedform integrated rate equation that would apply to Mechanism B under tight-binding experimental conditions.