On TrimerTrip, two non-ranked submissions with the AMOEBA force field using the same approach, but alternate handling of host conformations (AMOEBA/DDM/BAR/ALT1 and AMOEBA/DDM/BAR/ALT2), were used to examine how the selected TrimerTrip conformer impacts calculated binding free energies. The submitters examined so-called "indented" and "overlapping" host conformers which they identified in exploratory simulations. They find that these do not interconvert on the timescale of typical free energy calculations. The indented conformer resembles the annealed structure we provided in the SAMPL7 GitHub repository, while the overlapping conformer is very similar to the previously published structure of the unligated clip analog with four glycoluril units and interconverts relatively rapidly with a so-called "spiral" conformer with staggered triptycene walls .