The Enamine REAL database 60 contained 1,077,562,987 compounds when we downloaded it on October 11, 2019. To estimate the computational scalability of scoring compounds with the RF-C model from the model selection stage, we split the REAL dataset into 18 batches of about 60.3 million compounds each. Each batch was run as a job on an independent CPU compute node at the University of Wisconsin-Madison's Center for High-Throughput Computing using HTCondor. Each job processes the batch by generating the chemical fingerprint features and then making activity predictions using the RF-C model. The model was trained only on the training set, not the 1,024 AMS compounds.