Emle-engine was tested on the calculation of the conformational free energy surface of ADP in aqueous solution. We have obtained the surfaces corresponding to two different in vacuo ML potentials and three embedding options: MM embedding using fixed MM point charges, the static component of the EMLE model, which only includes the electrostatic component, and the total EMLE model, which includes electrostatic and polarization terms. All simulations resulted in stable trajectories for all umbrella sampling windows. Comparison of the results obtained for the six models to the reference ωB97X/MM surface shows that the EMLE embedding systematically reduces the average errors compared to MM embedding, with the latter not able to fully capture changes in the solute-solvent interaction energies associated with the conformational change. EMLE significantly improves the treatment of solute-solvent interactions, due to the dependence of the electronic density on the solute's geometry and the inclusion of the induction and polarization energy, which also depends on the configuration of the environment. Comparison between EMLE and DFT embedding energies shows that our model also correctly captures polarization effects, which can play an important role to discriminate among different environments. EMLE embedding is thus a promising model for ensuring an adequate treatment of the interaction between ML and MM subsystems, including for cases where such interactions are crucial to include, such as for simulating catalysis of chemical reactions, where the charge distribution of the reacting species changes significantly. The proposed framework is flexible enough to capture the changes in the interaction energy with the environment in such cases. The EMLE model can be easily fitted to work in any existing QM/MM framework: the QM energy can be substituted by the sum of the in vacuo MLP energy (depending only on the coordinates of the ML subsystem) and the interaction energy provided by EMLE, which is a function of both the ML and MM coordinates.