Compounds 1, 2, 4, and 5 show ligand interactions with 7WCM and compound 3 does not. The interactions between the ligand and protein are H-bonding and π-stacking. Compound 1 has the lowest binding energy at -9.38 kcal/mol. Compound 1 is also the most stable ligand-protein complex with relative binding-free energies of -45.03 kcal/mol and -39.51 kcal/mol. These results suggest the potential of cannabinoids to modulate GPR119, a receptor implicated in glucose homeostasis and insulin secretion .