We have shown E min , as calculated at the G4MP2 level of theory, to be effective in predicting synthesizability. G4MP2 is a composite quantum chemical technique in which a sequence of well-defined ab initio molecular orbital calculations is performed to arrive at a total energy for a given molecular species. The composite technique includes high level electron correlation energies and effects of large basis sets to give molecular energies accurate to better than 1 kcal/mol. These effects include detailed descriptions of electronic effects, including electron configurations as well as electron localization and delocalization; however, further analysis is needed to explicitly identify the key aspects that make E min so effective.