Inspecting the toxicokinetics of BPA, EFSA (2001) observed a threshold above which BPA intake can be harmful to the human immune system. This led to the establishment of 50 µg/kg bw/day as a tolerable daily intake (TDI) or a reference dose (RfD) for BPA corresponding to an SML of 0.6 mg/L . To allow further comprehensive substance-specific extrapolation from animals to humans, taking into cognizant the surging magnitude of BPA toxicity, EFSA established a human equivalent dose (HED) of 609 g/kg bw/day which was used as a reference point to establish an accurate health-based guidance value for BPA. An uncertainty factor of 2.5 for inter-species differences and 10 for intra-species differences were used by the authority to establish this health-based guidance. An additional factor of 6 was applied taking into cognizant the uncertainties surrounding the potential health effects of BPA on the mammary gland, metabolic, reproduction, neurobehavioral, and immune systems. As a result, an overall uncertainty factor of 150 was applied to establish a new TDI of 4 µg/kg bw/day which is 12.5 times lower than The TDI of 50 µg/kg bw/day . Hence, based on the t-TDI, the allocation factor and the exposure assumption, a current SML of 0.05 mg of BPA per kg of food must be kept to ensure minimal exposure to BPA below t-TDI to mitigate it from endangering human health .