The homochirality of the tetrahedral cages of general formula M4L6 can be attributed to the stereochemical coupling occurring between the metal centers, which is facilitated by the arylene rings comprising the cages' edges. In a study incorporating a series of C2-symmetric methylated pdiaminoterphenyls Nitschke group inferred that the diastereoselectivity of such self-assembly process is highly dependent on the substituents of the bridging edges, and the type of conformations they impose upon metal-coordination. Utilizing diamine ligands which preferentially adopt antiarrangement results in the preferential generation of homochiral T-symmetric cages. Conversely, ligands that adopt a syn arrangement tend to favour the formation of S4symmetric cages.