Amino acids are essential components for the existence of life on earth and they are responsible for the structure and function of proteins. Besides their biological role, they have been serving as starting materials for the synthesis of various drugs intermediates, 1 chiral catalyst, heterocyclic compounds, statins, -amino acids, 5 -amino acids, 6 and biodegradable polymers. 1,4-Didropyridine (1,4-DHP) is a semi saturated nitrogen-containing heterocyclic compound derived from pyridine as a parent molecule. As the scaffold of 1,4-dihydropyridine is the main constituent of many small molecule-based drugs, it emerged as one of the very important molecules in the pharmaceutical industry. Several substituted 1, 4-DHP derivatives containing drugs are clinically accepted as cardiovascular agents and they have been using for the treatment of hypertension such as nicardipine, amlodipine, nifedipine etc. 9 Some of the drugs containing DHP derivatives are shown in Figure . In addition, 1,4-DHP derivatives have also been used as antioxidant, 10 antimalarial, antibacterial, 12 antifungal, antiplasmodial, anti-inflammatory, and antidiabetic agents. Besides, they have also shown promising potential as HIV protease inhibitor, 17 anti-ischemic agents for treating Alzheimer's disease 18 chemo sensitizers in tumour therapy, platelet antiaggregatory agents, bronchodilators for treating tuberculosis, 21 cystic fibrosis, 22 asthma and neuroprotective agents in neuronal diseases. 24 Besides exhibiting biological activity these are well known as NADH bio-mimic and provides many examples of well-known hydride donors for reduction of alpha-keto electronwithdrawing conjugated olefins, cyclic enones, ketones to alcohols and hydrogenation of alphabeta unsaturated aldehydes and imines etc. Due to its wide applications, numerous methods have been developed for the synthesis of 1, 4-DHP derivatives. The classical Hantzsch method involving cyclo condensation of two equivalents of keto esters, aldehyde and ammonia as a nitrogen source by refluxing in water has been extensively used to synthesize 1,4-DHP derivatives. In addition to the Hantzsch method, various new methods and catalysts including lewis acid, 27 bronsted acids, 28 PhB(OH)2 and PPH3, metal triflates, 30 molecular iodine, organocatalysts, 32 TMS iodide, 33 and ionic liquids have been developed to improve the yield of the reaction. Using these methods, numerous derivatives of 1,4-DHP have been synthesized and studied. However, no method is reporting in the literature for the direct introduction of amino acid functional groups on the 1,4-DHP. This is possibly due to the lack of the commercial availability of starting material amino beta-keto esters. The amino acid functional groups may improve the biological activities of these DHP derivatives.