to DFT studies, HMF was adsorbed primarily on TiO2, while Au particles were responsible for the production of active hydrogen. One can cite the recent report by Ahmad et al. on the efficient use of a Mn functionalized graphene oxide as heterogeneous catalyst using H2 in THF. Ni is an abundant non-noble metal of choice for controlling the over-hydrogenation reactions, in contrary to high activity catalysts based on noble metals that often give undesired over-hydrogenation products like BHMTHF and DMTHF. The activity and selectivity of Ni-based supported catalysts in the HMF hydrodeoxygenation was shown to strongly depend on the support properties. Beside the prime role of the metal, it is well demonstrated that the support can drive the physico-chemical properties of the catalysts. In the case of the metal oxide supports, and in particular for reducible titania supports, controlling the structural and surface features of the support allows for a fine-tuning of both activity and selectivity of the catalysts through the alteration of e.g. the supported metal dispersion, particle size and composition, surface acidity, or metal-surface interactions. The influence of the TiO2 support nature on the catalytic behavior -and notably the nature of the crystallographic phases composing the support -has been shown for a span of supported metal catalysts, and for the conversion of several biomass-derived molecules. Our previous works showed that the content of anatase and rutile phases of the TiO2 support was driving the catalytic features in reactions like the synthesis of γ-valerolactone and γ-butyrolactone, or the hydrogenation of γ-valerolactone into 2-methyltetrahydrofuran, by influencing the Ru or Co metal particle size, the interactions with the support and the catalyst acidity. For the succinic acid hydrogenation, we showed that the co-presence of the rutile polymorph was of prime importance to get small-size Ru particles and induce stronger interactions with the support compared to a pure anatase support, both features driving the performances and the product distribution. In the same reaction, Hamdan et al. evidenced a strong influence of the anatase/rutile ratio on the selectivity with Mo carbides, while Tapin et al. showed that the support composition mostly impacted the conversion rather the selectivity for Pd catalysts, pure anatase favoring higher conversions. In the case of Ni catalysts, we demonstrated that the support composition influenced strongly the properties of the Ni particles and orientated the selectivity of the HMF hydrodeoxygenation by modulating the Ni-Ti interactions, the hydrogen adsorption, the Ni nanoparticle size and the surface acidity. Herein provided by Merck (Germany). Cristal ACTIV TiO2 PC500 was supplied by TRONOX.