attributed the role of trace water to degradation of dimethylformamide (DMF) and GBL solvents into acidic species, which promotes crystal formation by shifting the organoammonium protonation state equilibrium. Their key insight was that this could be achieved more reproducibly by deliberately adding formic acid; again their model implies that water would only promote crystal formation. Here, we report two counterexamples in which water hinders ITC crystal formation, discovered using a statistical analysis of historical data. Seasonal variations in ambient laboratory conditions influence reaction outcomes, but are generally not controlled and are often only communicated in intra-lab conversations. These variations provide "limited sloppiness" which is the basis for serendipity. Even without the ability to control all possible reaction parameters during each experiment, one can measure and record these data. Given enough observations, statistical methods can be used to identify unexpected correlations.