Nucleic acids have proven to be outstanding building blocks for molecular self-assembly. The precision and fidelity of base-pairing allows for predicting self-assembly patterns and optimization of the strength of the interaction. The advent of DNA origami has pushed further the boundaries of the possible structures designed with DNA, opening the door for the easy bottom-up assembly of user-defined three-dimensional structures with unprecedented accuracy. Although initial works in the field have mostly focused developing static structures, so-called structural DNA nanotechnology, a strong interest is now diverted towards the development of dynamic systems that reshape and actively interact with their surroundings .