The viral glycoprotein E may interact with a variety of receptors. The results in diverse cells are susceptible to the virus infection . Zika virus infection of fibroblasts, keratinocytes, and immature dendritic cells in humans is mediated by particular receptors such as DC-SIGN, AXL, TYRO3, and TIM-1 . The TAM receptor AXL is the crucial receptor for Zika virus entry. It is abundantly expressed in Sertoli cells and promotes ZIKV infection by boosting virus entry and negatively regulating the antiviral state . The neural cell adhesion molecule (NCAM1) is a possible ZIKV receptor . Tyro3, Axl, and Mertk (TAM) receptor tyrosine kinases support and regulate cell growth intrinsically. They perform a range of functions in the steady-state regulation of the immune response, including controlling the expression of critical target genes . TAM receptors contribute to the survival, proliferation, and differentiation of neural stem cells (NSCs) by regulating the production of neurotrophic factors, most notably NGF . TAM receptors promote neural stem cell survival, proliferation, and neuron differentiation . Nerve growth factor (NGF) regulates the expression of Axl and Tyro-3 receptors and has a role in the differentiation of PC12 cells . Tyro3 of Axl expression in PC12 cells are induced by Nerve growth factor (NGF) .NGF collaborates with TrkA to promote neuronal differentiation and survival .