Compounds Pt1-Pt4 are part of a series of cyclooctadiene compounds which were discovered through CO-ADD to have quite potent antibacterial activity. Some of these compounds showed distinct antifungal properties too. Overall, these four compounds were less potent compared to the other metal compounds in the series. Compounds Pt1, Pt2, and Pt4 showed a distinctly higher in vitro activity against the three Cryptococcus strains, whereas activity against the Candida strains was moderate. Promisingly, none of the four compounds showed any cytotoxicity or haemolysis up to 100 µM, encouraging further studies into this class of compounds for antifungal applications as well.