Synthetic Accessibility Score (SAscore) , used to assess the ease of synthesizing druglike molecules, rates molecules from 1 to 10 based on historical synthetic data and molecular complexity. Fragment contributions and a complexity penalty form the basis, derived from PubChem's vast molecule database. Validation against expert chemists' estimations shows strong agreement (r2 = 0.89). This method harnesses big data to streamline and enhance the synthesis evaluation process in molecular design.