Because there is a fundamental asymmetry in the curvature of its leaflets, the individual leaflets of the "Budded" system must be treated separately in the analysis. In case of the upper leaflet (blue curves in Fig. ), positive Gaussian curvature, K > 0, seems to correlate with faster diffusion, while regions with K < 0 exhibit slower diffusion. This behavior is verified by the analysis in Fig. , and goes against the conclusion drawn from continuum theories, where K > 0 results in slower diffusion and K < 0 causes faster diffusion. Similarly to the mean curvature, the speedup in the upper layer can be ascribed to a less dense packing of lipids, at least at the level of headgroups. This observed discrepancy between continuum predictions and molecular simulations is a direct consequence of lipid packing effects, which are usually not included in the continuum models. Even though the differences are minor in the systems studied here, they can be more significant with e.g. a more complex lipid mixture where the different lipid species are sorted by curvature.