To quantify the reduction in environmental impact relative to a literature protocol, an Environmental Factor (E Factor) was determined, calculated as the ratio of the mass of waste generated to the mass of product. This was evaluated for the 3step tandem sequence leading to Pyronaridine 9, starting with p-nitrophenol 10 (Scheme 9). This led to a five-fold decrease in E Factor to a very low value of 9, exemplifying the environmental friendliness of the described sequence. Overall, some of the major comparisons between an existing literature route and the current, far greener synthesis are summarized in Scheme 10.