In this study, a highly water-soluble ABA triblock copolymer, comprising 2-methyl-2oxazine as A blocks and 2-pentyl-2-oxazoline as block B, was successfully synthesized and blended via hot melt extrusion with indomethacin as model drug resulting in extrudates with different polymer:IND ratios of 2:1, 1:1 and 1:2 (w/w). Remaining crystallinity after HME of IND within the extrudates was visible but could potentially be removed by optimizing HME parameters. However, the remaining crystallinity of the drug was overcome by using MEW as a 3D printing technology, enabling the fabrication of microfibrous scaffolds with high porosity and therefore, improved surface area favourable for a fast dissolution of the polymer and drug release. Furthermore, MEW is a multi-parameter process leading to the advantage of adjustable scaffold design and therefore, the drug-loading content within the scaffold.