The nanoflow desalting platform was also used to examine other types of nucleic acids such as the single strand T4(G4T4)4 (11,283 Da) known to form G-quadruplexes. This sequence was annealed in ammonium acetate prior to analysis using the nanoflow desalting method. The resulting MS1 spectrum is shown in Figure , indicating a bimodal distribution of charges and two ion populations, labelled in blue and orange that correspond to the G-quadruplex sequence without additional adducts (blue) and the same sequence with inclusion of three potassium ions (orange), all corroborated by isotopic fits. Based on previous studies of G-quadruplexes, if this sequence adopts a G-quadruplex structure, it should be capable of intercalating three cations, the charges of which are offset by loss of three additional protons. The specific adduction of three potassium ions suggests retention of a G-quadruplex structure by the larger population of the ions in Figure . No other DNA or RNA strands exhibited this kind of specific potassium adduction in the present study and instead were reliably desalted. These results suggest the potential retention of structure through the desalting process and are actively being investigated.