Since then, we have continued the development of RanDepict and have implemented the option to depict Markush structures. Additionally, the generation of SMILES representations of Markush structures based on any given SMILES string that has been described in the section Selection of molecules was implemented. Furthermore, we contributed to PIKAChU , to allow the depiction of Markush structures and implemented its functionalities in RanDepict. Finally, RanDepict 1.0.8 was used to generate the chemical structure depictions in the training dataset pubchem_2, which contains Markush structures where the images were depicted with a size of 299 x 299 pixels. Here once again, one depiction was created without any augmentations, and three depictions were created with augmentations. This version of RanDepict produced some invalid SMILES representations of Markush structures resulting in a reduction of total images. Due to the large number of depictions (479,500,000 images) and the time and resources spent on their production, we decided to proceed with this dataset.