In this study, we used array synthesis to rapidly survey the chemical space of the opportunities to grow fragment F709, a piperazine hit from this screen. Synthesis was implemented as a robotics prototype platform based on the low-cost OpenTrons OT-1 TM liquid handler, while initial quality control (QC) of the crude reaction mixtures (CRM) used HPLC-mass spectrometric analysis, and all further bottlenecks (viz. extraction, solvent evaporation, purification, spectroscopic characterisation) were bypassed by the X-ray crystallographic analysis of the CRMs. The workflow enabled the synthesis of a diverse >1000-member library of compounds in just 2 weeks, with analysis requiring a further 2 weeks, and yielding early structure activity relationships (SAR) derived from 3D structures, as well as compounds with on-scale biophysical affinity.