Blind Submission. Alchemical solvation free energies in water and toluene were computed with an accelerated weighted histogram (AWH) method. The AWH method is an enhanced sampling technique that explores the free energy landscape via an adaptive bias to improve sampling efficiency. A standard parameter λ acts as finely spaced values in a discrete set that describes the van der Waals and Coulomb interactions of the alchemical path connecting the end states of the solute molecule in vacuum and in solution. While these interactions can be independently monitored, as part of the blind submission, a 13 λ point path (0.0, 0.1, 0.2, 0.3, 0.4, 0.5, 0.6, 0.7, 0.8, 0.85, 0.9, 0.95, and 1.0) was used to describe the simultaneous coupling of both types of interactions with one walker given the size of the system. A potential bias is applied by controlling the position of a harmonic potential using Monte Carlo umbrella sampling. Simulations were initially run for 1.4 ns and running the simulation in triplicate yielded uncertainties in the free energies. Results in the MM column in Table correspond to this method.