The Hydrogen Mass Repartitioning (HMR) method, introduced by Feenstra et al. in 1999, aims to extend the timestep in MD simulations by modifying the effective masses of hydrogen atoms. This technique increases hydrogen atom masses by approximately 3 atomic mass units (amu) while decreasing an equivalent amount from heavier atoms, maintaining the system's total mass. HMR's primary goal is to reduce high-frequency vibrations associated with light hydrogen atoms, enabling larger timesteps without compromising simulation accuracy or stability. By implementing HMR, researchers can utilize timesteps of up to 4-5 fs, significantly improving computational efficiency in biomolecular simulations. Hopkins et al. further validated this method, showing that applying HMR with a long timestep of up to 4 fs in various MD techniques did not introduce significant errors compared to simulations using a 2 fs timestep and normal masses, resulting an approximate twofold increase in simulation speed.