Complexes like I[82] (Figure ), with methyl α-D-mannopyranoside and methyl α-Dglucopyranoside to a pyridyl-2-triazole N-N structural motif were shown to exploit the glucose transporters for cellular uptake in cancer cells, associated to high cytotoxicity. Ruthenium(II) halfsandwich complexes like J[83] (Figure ) with bidentate monosaccharide ligands, were cytostatic in various cancer cell lines, the carbohydrate moiety having a determining role, while large hydrophobic protective groups were needed for biological activity.