The last two considered algorithms were PLS_VIP and SEQ_REM. The average importance scores estimated using these methods are shown in Fig. and Fig. , respectively. In case of SEQ_REM, the importance score is estimated using a random forest method based on the decrease of the impurity measure when the corresponding variable is used. As well as the Boruta method, both these methods are reproducible in order to estimate importance of MD but cannot be used for the MD selection for OLS linear regression. The accuracy of PLS regression itself was not investigated in this work.