The ability of organoboron compounds to reversible binding of various chemical entities, such as simple anions , sugars , polyols and catecholamines , is used in analytical chemistry . For this study, we have selected fluoride anion as a model analyte due to its importance in dental care and treatment of osteoporosis. The possible use of such sensors for indirect detection of phosphorofluoridate nerve agents can be also envisioned. However, due to strong hydration of the anion (ΔH° = -504 kJ mol -1 ) , its detection is challenging. The first attempts for the application of arylboronic acids as F -receptors were reported in 1995. Specifically, Shinkai et al. demonstrated that arylboronic acids are able to work as selective fluoride receptors in the presence of interfering anions, including other halides . In subsequent studies, it was demonstrated that arylboronic acids exhibit selective fluoride binding and are potentially useful in sensor development, with detection based on fluorescence, electrochemical or colorimetric methods. In this study, nineteen organoboron compounds from different groups were evaluated as potential ISE ionophores, with ten presenting sufficient hydrophobicity and solubility characterized in more detail using the miniaturized setup.