Driven by the continuous development of functional materials and technology, ion-selective electrodes (ISEs) became routine means of analysis for industrial, environmental and clinical applications (e.g. Rapidpoint 400 -Siemens Healthcare, Cobas c 311 -Roche Diagnostics, GEM Premier 5000 -Werfen, i-STAT 1 -Abbott Diagnostics). Clinical analysers and wearable health-monitoring devices allow for rapid, non-invasive and easy disease monitoring and diagnostic through such parameters as Na + , K + , Cl -, Ca 2+ , Mg and Li + 1 . Potentiometric sensors have been also used in environmental monitoring of anions e.g. F -, PO₄³⁻, SO₄² -, NO3 -, NO2 -, Cl -, CN -as well as cations Cu 2+ , NH4 + , Cr 6+ , Cd 2+ , Hg , Pb . The biggest advantages of this non-destructive technique include high dynamic range, ease of operation and low cost of the detectors, when compared to other sensing modalities.