Researchers have advanced the potential of CRISPR technology by employing pre-CRISPR reactions, expanding input size, and enhancing computing capabilities. With digitally displaying by microfluidic techniques, this breakthrough offers applications in DNA molecular encryption, cryptography, and steganography allowing for the encryption and decoding of digital inputs and message outputs through programmed molecular patterns on a substrate. The flexibility of the CRISPR system enables diverse input possibilities for real-world information encoding. Overall, this CRISPR-powered DNA computing system offers a simplified approach to large-scale molecular programming and has the potential to revolutionize DNA computing . It seems that development in CRISPR-powered DNA computation may show promise for applications in gene programming, editing, and modification of genetic disorders.