Hydroxide exchange membrane fuel cell (HEMFC) is an emerging technology for renewable electricity generation . The current state-of-the-art HEMFCs already have comparable performance to the more established proton exchange membrane fuel cells (PEMFCs). However, these HEMFCs require a very high platinum-group-metal (PGM) loading to catalyze the hydrogen oxidation reaction (HOR) at the anode , which is cost-prohibitive. The development of active HOR catalysts with low PGM loading is, thus, a critical step towards the implementation of HEMFCs. To improve the activity of PGM-based HOR catalysts, strategies including optimizing the binding energies of reaction intermediates (e.g., Hads or OHads) through modulation of electronic structures (i.e., d band centers) and bifunctional catalysis have been applied. In these approaches, PGMs are alloyed or doped with other metals (e.g., Fe, Co, Ni, Mo) , or are deposited onto an oxide surface to create a strong metal-support interaction (e.g., Pd-CeOx, Ru-TiO2) . Despite these efforts, few materials outperform the benchmark PtRu alloy in terms of both mass activity and intrinsic activity .