To further benchmark the performance of the CP 3 for practical applications, we computed a series of optical properties using three different proteins as examples. For this, we used the green fluorescent protein (GFP), a channelrhodopsin chimera (C1C2), and a flavin-binding dodecin, where the chromophores are an anionic 4-hydroxybenzylidene-1,2dimethylimidazolinone (HBDI), a protonated retinylidene Schiff base (PRSB), and a lumiflavin (LF) dimer, respectively. The chromophore in GFP and C1C2 is covalently bonded to the protein, whereas the LFs in dodecine are not.