However, we disagree that these are sufficient data to conclude de minimis risk, considering that the conclusion ignores terrestrial environments, assumes the lowest measured environmental effect levels are known despite lack of long-term chronic exposure data for other species, and does not consider diverse human exposure pathways in the context of increasing diet concentrations and potential unknown adverse effects. Given the persistence and accumulation of TFA, there could be other, unknown environmental and health impacts for which the current science is ignorant.