Crystallization stands as one of the most extensively employed techniques for achieving purification and isolation of target compounds. To successfully carry out a crystallization, it is crucial to have detailed knowledge of key phase behavior and physical properties, including solubility and the primary nucleation limit. Determining the metastable zone width (MSZW), which denotes the point at which the free energy barrier for crystal nucleation is surpassed, can prove to be a challenging and time-consuming task. While solubility measurements and modeling can offer some estimations, even slight variations in process parameters such as stirring rate, reactor geometry, or impurity profile can significantly impact the likelihood of primary nucleation. Hence, prior to embarking on compound isolation through crystallization, it is often necessary to directly investigate the MSZW within the intended reactor system to ascertain the reliability of the crystallization process.