Building on our previous work as well as that of Lin 4 and others, we initiated our studies with the development of a facile, mild, and efficient synthesis of benzhydryl triarylphosphonium salts (11). First, the aldehyde (9) undergoes activation, leading to the formation of the hydroxyltriphenylphosphonium intermediate (15). This intermediate then undergoes coupling with the arene derivatives (10) via Friedel-Crafts-type reactions (Figure ). Based on this foundation, we aimed to generalize this approach to achieve new chemo-and regioselective coupling of (hetero)arene derivatives (10) with aldehydes (9), leading to new examples of benzhydryl triarylphosphonium salts (11).