Given the lack of experimental data, the choice of bead chemical types in this work partially relied on COSMO-RS predictions. While COSMO-RS has demonstrated accuracy in logP predictions and has been used effectively in other studies for Martini parametrization , the adoption of this approach means that the Martini 3 lipid models developed here are based on a fully bottom-up strategy. This kind of approach should still be considered with caution, as it may not fully align with the Martini parametrization philosophy. This is one of the reasons why consistency with experimentally determined bead assignments was also considered. Further experimental validation of atomistic force fields and thermodynamic properties will be crucial for future refinements of the Martini 3 IL models presented here.