Use of the GFN1-xTB/GBSA method increases the median CPU time requirement from 43 to 60 seconds and the total time for all 535 increases from 10 to 17 hours. In order to mitigate the increased computational cost, we tested the use of the GFNFF-xTB force field to pre-screen the conformers. If only conformers with GFNFF-xTB/methanol energies within 3 kcal/mol of the lowest energy conformer are re-optimized using GFN1-xTB/methanol then the number of correct, semi-correct, and failed predictions (485, 29, and 21) are essentially unchanged (Table ) while decreasing the median CPU time per molecule to 33 seconds and total time to 8 hours.