For example, conformational analysis of the core pentasaccharide derived from the lipooligosaccharide of pathogenic bacterium Moraxella catarrhalis was recently performed using molecular simulation and NMR. It was shown that the addition of one glucosyl unit to each of the -(14) and -(12) branches of this core pentasaccharide led to a significant change in conformation, into a more folded compact structure, with significant potential implications for the minimum epitope to target in vaccine design.