A second major area of development in the new version has been in the growth and reorganization of the way 3D models for docking are built, organized, and distributed. ZINC-22 is now a federation of many smaller databases (see Methods). By breaking the database up into smaller parts, each part can be prepared asynchronously, concurrently, and scaleably (this was a problem in the earlier version of ZINC, and we suspect any similarly organized database, because of the limitation of a single registration pipeline). The database is now organized in a four-dimensional space: