In summary, we use BEMD and PTMetaD-WTE with CHARMM22* and CHARMM36m protein force-fields to effectively sample IDP conformational landscapes within a microsecond timescale. We apply this approach to elucidate the structural and thermodynamic properties of an archetypal IDP sequence derived from N-terminus of DEAD-box protein DHH1 . DHH1N is a 46 amino-acid sequence that contains a low fraction of hydrophobic residues [Supplementary Note 1].