A recent review by Dekant and Dekant summarized the mammalian toxicity of TFA, referring specifically to human toxicity. Most toxicity tests on which human health risk assessments were based are rat studies, which found mild liver hypertrophy (increased size of the liver) as the lead effect at concentrations > 1000 mg/kgbw. More human-relevant tests directed towards a mechanistic understanding and not only towards filling regulatory apical endpoints should be conducted in the future. Currently, there is an intention under EU Regulation 1272/2008 on the Classification, Labelling and Packaging of Substances and Mixtures (CLP) to classify TFA and its salts under Category 1B: Presumed human reproductive toxicant, based on new evidence of embryo-fetal developmental toxicity in rabbits, submitted to the European Chemicals Agency (ECHA) by Germany . If TFA were to be classified as toxic for reproduction, this could have an impact on future threshold values in food and drinking water.