Interestingly, a notable n umber of LPAs disclosed vigorous antiviral activity in particular as Anti-HIV-1. Indeed, the lamellarin A 20-sulphated compound showed potent terminal cleavage inhibitory activity with an IC50 = 16 μM and strand transfer activity with an IC50 = 22 μM against a purified integrase enzyme. Moreover, it disclosed significant inhibitory activity against the early steps of HIV-1 replication at low to sub-micromolar ranges .