After nine hours of exposure, small intestines were collected from mice. The small intestinal villi were then stained with Alcian Blue. Here, we observed goblet cell reduction to be similar for pan-BET inhibitor I-BET151, BRD4-selective inhibitor 1, and pan-D1 biased inhibitor 3 (Figure ). The lack of reduced toxicity from 1 may suggest goblet cell toxicity is being driven by BRD4 preferentially over the other BET proteins; however, more experiments would be needed to support this hypothesis. We did not observe diarrhea in our short-term experiments.