The challenge is to optimize TS structures when most FFs have been developed for ground structures. To solve this, specific FFs have been developed (i.e., ReaxFF), while other methods rely on a combination of ground state reactants and products (i.e., empirical valence bond (EVB)), multi configurational molecular mechanics (MCMM), and SEAM ). Although these methods are available to the scientific community at large, they still require expertise in computational chemistry, scripting, and/or computer environments to be truly usable in chemistry laboratories. In this context, another two approaches, ACE and Q2MM, were implemented into user friendly platforms (VIRTUAL CHEMIST and CatVS, Box 3).