HpaA is a surface protein discovered in Helicobacter pylori, a bacterium recognized for inflicting gastric infections, such as gastritis and peptic ulcers. Recently, a 3D structure of H. pylori has been crystallized using X-ray crystallography. This is the first 3D structure of the HpaA protein that has been elucidated, and therefore, the current study is also the first computational-based HpaA-antibody complex modeling study. HpaA is an adhesin which helps the bacterium adhere to the gastric epithelial cells inside the human stomach, facilitating colonization and contamination . This protein is essential for H. Pylori's capacity to establish a continual infection in the harsh, acidic environment in the stomach . Due to its position in bacterial adhesion, HpaA is being studied as an ability target for vaccines or healing interventions to stop or treat H. Pylori infections . Molecular docking is a modern computational tool that has become extremely important for drug discovery. . It predicts the stability and binding affinity between a molecule and its ligand. . The design method uses mathematical algorithms to analyze the best configuration between the drug and the target molecule .