These new indices give more freedom at the time of performing any similarity-based analysis, because now we can study correlations between an arbitrary number of molecules. Reassuringly, it has been already shown that they are internally and externally consistent with respect to the newly introduced hyperparameter γ.[133, 137, 138] The former implies that they will rank multiple datasets in the same way, largely independently of the value of γ. The latter reflects the fact that the ranking obtained from extended indices and the ranking obtained from standard binary indices will also be the same over most γ values.