Limited evidence of similar folding / fusion features such as those commented above, are available for gpGVHSV. Nevertheless, the mapping of discontinuous epitopes on gpGVHSV of VHSV-specific neutralizing monoclonal antibodies , and the results of some mutagenesis studies affecting gpGVHSVdependent fusion confirmed some similarities. Additionally, gpGVHSV / gpGVSV pepscan peptides displayed homologous locations for anionic phospholipidbindings , for induction of interferon or activation of autophagy . Therefore, the present working hypothesis was that the gpGVHSV main folds and earliest fusion transitions, were similar to those of the gpGs of mammalian rhabdoviruses. In particular, the main purpose of this computational work was to explore the sequence-conserved R4-TrD interface at the pre-fusion gpGVHSV homotrimers (Supporting Materials / 89VHSValignement.docx).