Intrigued by these results, we became interested in applying this photocatalyst for late-stage transformations (LST), since LST represents an effective strategy for specific chemical transformations in complex molecules. Indeed, the application of LST to a complex molecular structure facilitates the generation of a novel, valuable, and functionalized molecule . Recognizing the potential of aromatic CF3-containing molecules to enhance antibiotic, antitumor, and antidepressant properties in pharmaceuticals, we reasoned that our straightforward synthetic approach should pave the way for advancing drug discovery through LST. As shown in Scheme become an interesting candidate for fragrance and triple-negative breast cancer treatment. Furthermore, a trifluoromethyl group was successfully installed in a fungicide (famoxadone) to protect agricultural products against various fungal diseases on fruiting vegetables, tomatoes, potatoes, cucurbits, lettuce, and grapes (3ac, 51%). In addition to LST, we have pursued the direct synthesis of pharmaceutical compounds from their immediate precursors. The antidepressant fluoxetine (3ad), a selective serotonin reuptake inhibitor with affinities for various serotonin receptors, was successfully synthesized through our approach. Employing N-methyl-3-phenoxy-3-phenylpropan-1-amine as the precursor yielded the drug molecule with a significant yield and selectivity (60%, 10:1). This subtle structural modification led to a remarkable enhancement in serotonin uptake selectivity . Additionally, the diphenyl ether derivative, fomesafen (3ae), was synthesized from its direct precursors with a moderate yield but notable para-selectivity (45%, 10:1). This transformation resulted in the production of one of the most widely used herbicides in soybean and peanut fields, owing to its potent herbicidal activity at low concentrations . The synthesis of flufenoxuron (3af) using our approach yielded the desired product with a 55% yield. This trifluoromethylated product, recognized as a benzoylurea pesticide, serves as an insect growth regulator and chitin synthesis inhibitor, effectively controlling immature stages of insects . (g) 1 H-15 N CPMAS and (h) 19 F MAS NMR spectra of Cu@f-gC3N4 catalyst at 14.1 T. Spinning sideband is marked with an asterisk.