This revealed a potentially better acceptance of the nucleophiles nitrite, chloride and cyanate by HheG-682, as significantly higher conversions were obtained for this enzyme in comparison to HheG. 2-chlorocyclohexanol (20) (Scheme 1) using the spectrophotometric halide release assay. As shown in Figure , HheG-682 is slightly more active than HheG in the dehalogenation of haloalcohols 14, 15