MONs were incubated with the phage library in 2x blocking buffer (BB) phosphate buffered saline for 1 h on a rotating blood wheel. The particles were washed three times with PBS to remove unbound phage. After each wash, the frameworks were isolated by centrifugation (relative centrifugal force (RCF) 10 000 × g) for 10 min, and the supernatant was discarded. Bound phage were eluted with 0.2 M glycine pH 2.2, followed by trimethylamine. This resulted in MON digestion for ZIF-7 and ZIF-7-NH2 so it is assumed that all bound phage were eluted. The eluted phage were amplified in E. coli (ER2738) and purified by poly(ethylene glycol)-8000/sodium chloride (PEG/NaCl) precipitation with subsequent centrifugation steps. In subsequent biopanning rounds, at least 5 × 10 10 phage were applied to a fresh solution of MONs in PBS. A total of three panning rounds were conducted to enrich the peptide pool with the highest affinity binders. For each MON system, 12 phage clones were analyzed by DNA sequencing.