In this work, we proposed that the intrinsic OAM polarization induced by the bulk chirality can drive the enantioselective reactions. We successfully obtained two PdGa bulk crystals with opposite chiralities and then studied their response toward the oxidation of DOPA enantiomers. It is found that the electro-oxidation of L-DOPA and D-DOPA is strongly dependent on the bulk chirality of PdGa crystals. The difference in oxidation behaviors can be explained by the classical thermodynamic adsorption theories, with the adsorption energies of L-and D-DOPA being different at the same crystal surface of PdGa. To understand the origin of adsorption differences, we performed a theoretical investigation on the PdGa crystals and found the existence of strong OAM polarizations, with their signs being chiral-dependent. Considering the mirror-symmetric orbital polarization of O 2p orbital in DOPA, we believed that the enantioselective adsorption of DOPA is driven by the polarization mismatch between the DOPA adsorbates and PdGa substrate. Our work suggests that the enantioselective reactions could happen on pure crystals without any surface modification, which provides a potential strategy for asymmetric synthesis on pure inorganic crystals or minerals.