Conducting polymers such as polypyrrole (PPy) and polyaniline (PANI) were amongst the first materials to constitute bioelectronic devices owing to their high biocompatibility and ease of synthesis. However, low processability of the materials after synthesis limited their further development. More recently, synthetic efforts to ensure mixed ionic-electronic conduction focus on the introduction of hydrophilic motifs to CPs to allow for interaction with polar environments in organic electrochemical transistors (OECTs). Successful examples of which are the use of side chains containing glycol functional groups or pendant polar moieties. However, the intricacy in fine-tuning these materials often limits accessibility beyond the synthetic chemistry laboratory. Consequently, Poly(3,4ethylenedixythiophene):poly(styrene sulphonate) (PEDOT:PSS) is the most renowned organic mixed ionic-electronic conductor (OMIEC) used in bioelectronics and cell culture studies due to simplicity in its production, in addition to having high processability and electronic performance. Though this renders PEDOT:PSS readily available to researchers across various disciplines, being limited to just one CP for all applications narrows the material space and opportunity to explore new technologies.