In recent years, there has been a shift in focus towards the development of point-of-care testing (POCT) devices for achieving wellness rather than just diagnosing diseases. One area of great interest in POCT is the detection of albumin, the most abundant protein in blood. Paper-based technologies have been gaining attention due to their ability to meet the demands of various endusers and manufacturers. Numerous studies have been conducted on paper-based microfluidic devices to achieve low-cost, sensitive detections of albumin. However, many of these studies have provided only qualitative or semi-quantitative results and require further improvements. To achieve commercial success, it is important to investigate the type of paper and introduce state-ofthe-art technologies for stable mass manufacturing. Further research and development of paperbased biosensors may eventually pave the way for their application in personalized diagnosis, reducing the disease burden and increasing the quality of human life.