Performances of OER,and GOR were attributed three effects, i) its loosely stacked, ii) layered sheet-like structure with nanocutting channels along the edges, and iii) the presence of a synergistic effect between the distinct metal ions within the MOF. In fact, Fig. gives a summarized analysis of CoNi(1:3) MOF performance for glucose oxidation with two ranges of concentration, first range (2µM to 500µM), and second range is to (1mM to 15mM), and as well as a respectively linear relationship between concentrations and current densities is done. Moreover, the CoNi(1:3) MOF provides higher performance by delivering at least overpotential of 348 mV at 20 mA/cm 2 , and as well as higher stability for OER. Also, it exhibited superior glucose detection limit of (1.03µM) by synergy. So, authors expect that this new nanomaterials would be a great advantages in the OER and GOR perspectives. Nikov's team has been long-time ago, suggested the glucose oxidation over alumina supported Palladium (Pd/Al2O3). So, a catalyst deactivation has been featured to happen by the Pd-O formation in the metal lattice attended by the adsorption of the reaction products. Many properties have been considered such as the effects of material mass, glucose concentration, particle diameter, and as well as the multiple use of the catalyst on the targeted product conversion. Furthermore, Wang's research group studied the tuning structure effects of Platinum (Pt) shells on Palladium (Pd) nanocubes as a neutral glucose oxidation catalyts and sensors. Indeed, the stellated Pd@Pt NCs (Pd@Pt SNC) with (211) facets showed an electron transfer number of 12.69 and a higher specific activity than other concave Pd@®Pt NCs. Also, it is described that Pd NCs with Ptcoated corners (Pd@Pt CNCC) with index facets of ( ) and (950) exhibited a sensitivity of 11.06 µA.mM - 1 .cm -2 and a linear range of (2.4-10.6) mM. As the fabricated electrode gives higher recoveries (98.8 -99.85)% and low relative standards (≤ 1.06 %) in the serum sample, it is suggested that this electrode (Pd@Pt CNCC) might be useful as a non-enzymatic glucose sensor. Although these activity, the electrode may have high costs, as it is constructed with noble metals. So, to decrease the loading of noble metals on glucose oxidation catalyst synthesis, Li's group proposed the use of MnO2-C nanocomposite to anchor the gold nanoparticles (Au NPs). In fact, it is observed that Au NPs are uniformly distributed on the support (MnO2-C). Higher catalytic activity has been notified for the constructed catalyst (Au/MnO2-C)NPs than other considered catalysts. This was supported by the effect of MnO2 toward GOR. In particular, it is thought that MnO2-C hybrid composite is an auspicious approach for decreasing noble metal catalyst charging. Moreover, a very cheap catalyst than (Au/MnO2-C)NPs catalyst is reported from Hong's research team . Where, a (110) faceted rhombic dodecahedral (RD), (111)-faceted octahedral (OCT), and as well as (100)-faceted nanocube (NC) Cu2O crystals have been demonstrated as D-glucose oxidation catalyst. Specially, due to the facile surface oxidation of CuO, the RD catalyst showed an early rest potential of -0.228 V vs (Ag/AgCl,3mol/l KCl) and it has higher specific activity compared to other catalyst forms. This demonstrated that the catalyst structure plays a crucial role in the catalysis reaction mechanisms.