A further difficulty in using gradient experiments to provide fits that will yield parameters that provide accurate prediction of both isocratic and gradient retention factors, is finding an appropriate experimental design for the gradient experiments, specifically the initial mobile phase composition, I, the final mobile phase composition, F, and the gradient time, tG. As a part of the present study, we develop a strategy to identify a minimal number of experiments that can provide adequate data to allow for successful fits to the reparameterized NK equation. Here, we have tested this design strategy with both simulations and experimental data. We find that we can successfully fit the data and predict accurate isocratic retention factors using this experimental design strategy.