The research focused on aging mechanisms and attributes, and the anti-aging strategies and medical interventions, has undergone a steady growth, especially intense in the last decade (Figure ). Indeed, the desire for enjoying a lifespan in a healthy, youthful condition is a universal human appeal. A characteristic feature of anti-aging medicine is that it is proactive rather than reactive, trying to avoid disease via health preservation rather than cure disease after it occurs. Its basic approach is replacement therapy. Since appropriate knowledge and expertise allowing to slow or halt the homeostatic decline in basic informational, regulatory, and protective molecules upon aging has not yet been established, replacement of those products such as hormones, cofactors, antioxidants, and others, is routinely employed. Such a proactive approach meant to slow down or escape the development of age-associated disease is more rational than a reactive, symptomatic approach. Figure 2. Yearly growth of the number of documents (patents and non-patents) in the CAS Content Collection™ related to the aging mechanisms and anti-aging strategies.