Neither any gpG domain, nor peptides, nor small drug-like molecules, have been reported to inhibit the low-pH induced transitions in rhabdoviruses, in contrast to other enveloped viruses (i.e., human respiratory syncytial virus) . Nevertheless, some antiviral compounds of broad-spectrum inhibiting salmonid IHNV rhabdovirus by targeting their phospholipids have been proposed . More recently, natural extracts with limited affinities against SVCV infections have been proposed, such as, arctigenin (F. Arctii), bavachin (P. corlifonia), saikosaponin (B. yinchowense) and anisomycin (S. griseolus) or semi-synthetic derivatives from arctigenin , coumarin and quinoline . Therefore, high-affinity, low-toxicity (low environmental risks) drug-like small molecules to interfere VHSV rhabdoviral outbreaks or further investigate their fusion mechanisms, would be most welcome.