The conventional MFCC scheme for the calculation of protein-ligand interaction energies corresponds to a two-body approximation if the ligand is considered as an additional fragment. It can be recovered by applying our MFCC-MBE(2) scheme to both the protein and the protein-ligand complex and after removing all terms that cancel in the protein-ligand interaction energy. Here, we have presented an upgraded scheme for the inclusion of three-body contributions in the calculation of protein-ligand interaction energies. While it is equivalent to an MFCC-MBE(3) scheme for the total energy applied to both the protein and the protein-ligand complex, it can be derived straightforwardly by including the ligand in each term of the MFCC-MBE(2) energy.