The conservation of similar F13L-Tecovirimat predicted docking cavities in the top-children ligands to the F13L resistant mutants, could be interpreted as a favorable prediction sign of their possible MPXV inhibitory activities. However, predictions remain highly hypothetical because the absence of crystallographic structures, limitation to pooling the most abundant resistant mutations and/or lack of experimental confirmations. Nevertheless, perhaps similar strategies could be applied once the prevalence of 2024 outbreak Tecovirimatresistant MPXV mutants would be more studied.