Computational generations of drug-like, non-toxic, nanoMolar affinity conformers have been derived from 3-fold star-shaped parents targeting P.falciparum CSP ordered-cavities. Many of the newly predicted top-conformers cross-docked N-(signal-peptide-dependent) to C-terminal cavities and/or Cterminal cavities. These new CSP targets may constitute proof-of-concept examples for in vitro basic research, complementing the immunodominant protective antibodies which included some CSP disordered repeats. Among their most important limitations, these candidates may suffer from: a) CSP modeldependence, b) limited numbers of parent molecules, c) possible resistant mutations, and d) rigid amino acid side-chain cavities. Although some of these limitations may generate practical issues, the hundreds of conformers generated may favor alternative selections. Additional efforts may be required to continue drug-like explorations into the enormous chemical space possibilities . In addition, these predictions may complement the co-evolution generation attempts to propose new volatile non-toxic compounds targeting anti-odor common coreceptors of malaria-vector mosquitoes .