Higher reaction temperatures were nevertheless attempted for the asymmetric approach using the chiral lithium amide obtained from 11 (Scheme 7). In this study we observed that the reactions performed at higher temperatures resulted in lower diastereoselectivity and conversion. The area percent (A %) analysis of the quenched crude reaction mixture by liquid chromatography (HPLC A %) showed that the syndiastereomer pair, 3 and ent-3, was obtained in only 31 % at -60 °C (1.6:1 d.r.) and 21 % at -40 °C (1.3:1 d.r.), compared to 69 % at -78 °C (7.7:1 d.r.). Although d.r. and conversion were negatively influenced, the effect on the enantioselectivity was surprisingly inverted and the reaction at -40 °C provided a higher enantioselectivity (54 % ee) compared to the reaction at -78 °C (35 % ee).