This broad survey of species transport and transformation in various disease contexts reveals a common refrain: these processes are not merely passive mechanisms but active participants in shaping disease pathogenesis. From the intricate diffusion of signaling molecules to the convection driven by bulk flow of fluids, each mechanism plays a critical role in maintaining physiological equilibrium. Disruptions in these delicate balances, whether through altered diffusion rates, impaired bulk flow, or aberrant reaction kinetics, are intricately linked to the development and progression of numerous diseases. This review highlights the interconnectedness of these processes, emphasizing their impact on biophysical and biomechanical stability within different organ systems. The analysis underscores the importance of integrating biochemical, biophysical, and biomechanical perspectives in understanding disease mechanisms and developing targeted therapies. Interdisciplinary research is essential to bridge existing knowledge gaps, leading to more effective interventions and ultimately improving patient outcomes.