To ensure airflow drawn by the vacuum pump would be sufficient for e-cigarette actuation, we selected porous filter paper as a matrix for vapor deposition. We reasoned that a pore size roughly equivalent to the diameter of e-liquid aerosols (0.3-3 μM) would maximize the quantity of potential drug material adsorbed during actuation. Figure shows that a 2.5 μM pore size filter performed best for both indole-and indazole-based SCs, thus was selected for use. Ashless paper was selected for use in the device as negligible autofluorescence was detected upon irradiation with a 265nm LED (Figure ). E-cigarettes are designed with an integrated timer that cuts battery power at ~10s to prevent coil damage. We have designed our device to perform a 20s pumping step, incorporating ~10s actuation and filter 'drying' stages. We find the additional drying stage has a homogenizing effect on adsorbed material as it is pulled though the porous filter, providing consistent optical detection.