The homology models of EPAC1 in the active and inactive conformations were prepared using the SWISS-MODEL webserver. The FASTA sequence was obtained from the UniProt database (entry O95398). X-Ray diffracted structures of EPAC2 were used as templates when constructing the protein models: and EPAC2-cAMP analogue complex (PDB ID: 4MGK) and apo EPAC2 (PDB ID: 2BYV) for active and inactive conformations respectively. The active conformation template lacked the DEP domain, which therefore was copied from the inactive conformation using PyMol.