• The benefits of PT2 regularization for intermolecular interactions and large molecule reactions are negated by the losses for small molecule thermochemistry, barrier heights, and conformer energies. Hence, κ-GLPT2 correlation causes no significant reduction in WTMAD2 compared to the unregularized revDSD-PBEP86-D3BJ, revDSD-PBE-D3BJ, and xDSD75-PBEP86-D3BJ functionals. However, the significantly better performance of κDSD-BLYP-D3BJ at κ=2.2 for large-molecule reactions has enough impact on WTMAD2 that overall, it marginally outperforms revDSD-BLYP-D3BJ. Replacing D3BJ by D4 dispersion does not affect those trends. • If we eliminate spin-component scaling (i.e., c2ab=c2ss), the WTMAD2 gap between the κmin and κ=∞ (i.e., unregularized) forms of κ(x)DH-XC-D3BJ are more significant than that we obtained for the κ(x)DSD functionals. In contrast, for the κ(x)DOD forms, unregularized functionals always perform better. • Regularization of the GLPT2 terms in double-hybrids is most helpful at lower percentages (e.g., 50%) of HF exchange. At higher percentages of HF exchange, the benefits for intermolecular interactions and large-molecule reactions are outweighed by the deterioration in the remaining three subsets. At lower percentages of HF exchange, the benefits are heightened and the deterioration is mitigated, hence an overall beneficial effect.