Per-and polyfluoroalkyl substances (PFAS) are compounds of high public interest as there is increasing evidence that exposure to PFAS can lead to adverse human and environmental health effects . These concerns are accompanied by their documented accumulation in the environment (as so-called "forever chemicals") due to their widespread use and stability . Well-known PFAS include older PFAS such as PFOA (perfluorooctanoic acid) and PFOS (perfluorooctane sulfonic acid), as well as newer PFAS such as GenX (a replacement product for the older PFAS). There is strong regulatory debate about PFAS, including calls to regulate them as a class and for better approaches to detect PFAS in humans and in the environment. Since PFAS and replacement PFAS products are a fast-moving business, cheminformatics tools are gaining importance in identifying candidate PFAS compounds from within scientific and other text sources such as patent repositories, including in-house confidential business documentation.