Applying MIST to the CASMI 2022 dataset necessitated preprocessing with SIRIUS, a step that was somewhat obfuscated by the lack of explicit documentation and required investigating the code to determine the required data types and directory structure. Note that the recently updated MIST v2.0.0 has simplified this process by eliminating the SIRIUS preprocessing dependency. These challenges underscore that MIST, in its current form, functions more as a research prototype than a fully fledged tool designed for end-user application.