To account for this, we try to "encourage" the reactants to go to previously undiscovered products, by including products found by other MD simulations when computing the biasing potential. After filtering the 588 reactions found in the first set of runs with RMSD-PP estimated barriers, 318 reactions are left for DFT refinement. For the second set of runs (initiated with products from the first set of runs), after filtering based on both RMSD-PP barrier estimates and duplicates of reactions from the first run, 174 reactions are left for DFT refinement. We find one additional target reaction in this way: R129. Two (R7854 and R10077) of the remaining three target reactions can be found with meta-MD by changing the parameter set to our secondary choice (k push = 0.03, α = 0.7 and s = 0.6).