The insertion of indium into reactive allyl halides, propargyl halides and α-halo esters via Barbier or Reformatsky-type activation modes is well precedented. Furthermore, the activation of aryl halides using elemental indium alongside additives such as LiCl and Co catalysts has enabled the use of arylindiums in a variety of transition metal-catalyzed cross coupling processes. In contrast to these methods, the use of indium metal for the insertion into 2-azinyl halides to form the corresponding heteroarylindium species and their subsequent role in productive carbon-carbon bond forming reactions is limited to a solitary report, to the best of our knowledge. In this case, an indium mediated addition of 2iodopyridine to neat aldehyde at 75 ˚C generated the corresponding 1,2-addition product, although no details were provided on the nature of the putative 2-pyridyl nucleophile. In contrast, the mild and operationally straightforward reaction conditions afforded by the near equimolar multicomponent coupling reaction of our new CAzA reaction offer a modular and potentially general entry into highly functionalized and structurally complex 2-azinyl tertiary alkylamines. Although the CAzA process requires 1.5 equivalents of indium powder as a reductant, it is notable that no other metal additives or catalysts are required. This draws an interesting distinction to related, but mechanistically disparate, reductive processes that form similar products reported by the groups of Reisman and Doyle, in particular. In these cases, a transition metal catalyst is required in addition to the use of a stoichiometric quantity of a metal reductant to afford the desired products.