Despite the fact that the periodic table restricts the number of elements to 118, these 118 elements can form thousands of compounds. As a result, substantial effort has gone into developing new analytical methods capable of analyzing the compounds as required. Because MS techniques provide direct molecular structure information on the analytes of interest, they stood out among the many analytical methods as promising instruments in science and technology. It is worth noting that analyte molecules should first be in a gaseous state before being ionized efficiently with the help of an appropriate ionization source. Almost all compounds, with the exception of proteins, peptides, and nucleic acids, exist in a neutral state. Because it is required to ionize neutral molecules, the ion source is referred to be the MS's heart in MS. When it comes to quantification, the effectiveness of the ionization source determines the performance of MS. As a result, developing effective ion sources is essential. Traditional ion sources including electron ionization (EI) , chemical ionization (CI) , fast atom bombardment (FAB) ionization , Penning ionization and electrospray ionization (ESI) ] require a vacuum system, which makes the MS heavier and bulkier, whereas miniaturized-MS system is required for practical applications.