Surface functionalisation with magnetic NP Fe 2 O 3 has become prevalent due to the their low, toxicity, low cost, biocompatibility, and high electron communication. Due to their dipolar attraction leading to a tendency to agglomerate in biological solutions, chitosan is commonly used for the dispersion of these NPs on an electrode surface. Metallic coating such as Au or Ag NPs are used form a shell around magnetic beads to stabilise the them in solution and further enhance the electrochemical behaviour. The magnetic properties of Fe 2 O 3 NPs provide the unique ability to separate and isolate target molecules in biological samples through the use of an external magnet or applied magnetic field. An external magnet has also been exploited by some groups to immobilised antibody conjugated magnetic NPs onto the electrode surface. A study reported by demonstrate the use of anti-Zika virus monoclonal antibody modified magnetic nanoparticles to capture the virus particles, which are also labelled with Pt nanoparticles. After the enrichment of the virus sample, a lysis protocol was applied and the resulting sample was studied with an paper based micro chip by applying electrochemical impedance spectroscopy. Developed impedimetric biosensor based on magnetic beads separation is a highly cost-effective platform for ZIKV detection.