As outlined above, we believe that biocatalytic nucleoside synthesis stands to profit immensely by embracing interdisciplinary science. This holds particularly true for the combination of biocatalysis and organic chemistry. While either discipline by itself has, thus far, fallen short of achieving "efficient" nucleoside synthesis, we are convinced that a union of the two fields will be well equipped to overcome the existing challenges. Impressive demonstrations of such efforts have recently made headlines in various subfields of chemistry, and we expect nucleoside synthesis to follow these developments soon. Indeed, the recent work of Benkovics et al. provides an inspirational example to this end. In their synthesis of the cyclic dinucleotide MK-1454, the combination of organocatalytic fluorination and thiophosphorylation with enzymatic triphosphorylation and cyclization provided the tools for a highly selective synthesis of an enormously challenging target on the process scale.