Despite the encouraging progress in VSC experiments, we do want to point out that there are experimental efforts that try to reproduce the published VSC results but can not find any apparent VSC modifications. One of them is an early attempt in Ref. to produce the enhancement of the hydrolysis reaction but not being successful. The second one was an attempt to reproduce the VSC enhancement on a hydrolysis reaction coupled inside an FP cavity, but cannot reproduce the effect. However, there is a new attempt at reproducing the same hydrolysis reaction coupled to a plasmonic cavity and did find an enhancement of the rate constant . In that same work also tried to conduct this reaction inside the FP cavity and claimed to reproduce the VSC enhancement effect. As such, the reproducibility of these observed VSC effects remains an open experimental challenge and needs to be addressed in the future. Nevertheless, a good overview of technical concerns with the VSC flow cell experiment is given in Ref. . In a different direction, recent experimental investigations on CN radical-hydrogen atom abstraction reaction do not reveal any noticeable change in the rate constant, even though the molecular system is under the strong coupling condition. However, these seemingly null results on the VSC effect have the potential to indirectly inform the fundamental mechanism and limitations of the VSCinduced rate constant modifications, and provide insights into when VSC will not be able to change rate constants.