Comparison between the experimental and the calculated P (r) indicates that the Metainference model tends to overestimate the presence of larger assemblies, illustrated by the location of the peak of the distribution at longer distances. Re-weighing the contributions of each assembly size to match the P (r), quantitative agreement with the experimental curve is retrieved (Figure ; SI, Table ), indicating that the moieties identified by Metainference are representative of the experimental population. The relative abundance may not be correctly weighted due the relatively small number of replicas of the simulation compared to the high polydispersity observed for TX-100, which may cause the over-weighting of larger organisations.