Here, we explore the similarity between measured and predicted protein-ligand interaction patterns (represented as PLIFs) as a function of molecular relatedness (quantified as the Tanimoto coefficient based on Morgan2 fingerprints with 2048 bits). We expect the protein-ligand interaction patterns derived from measured data and docking poses to be more similar for structurally related compounds than those of structurally distinct ones. It is reasonable to assume that structurally related ligands generally form similar interactions with the same target protein.