Curiously, these groups are not very polar and are well-behaved on silica gel (nice round spots on TLC, see Supplementary Materials for pictures). Catalysis is demonstrated with Ni, but the same principle should be applicable to many other organometallic systems. In fact, preliminary experiments suggest that other metals such as Cu, Co, Pd, and Fe, can provide varying levels of product in C(sp 3 )-C(sp 2 ) coupling (see Supplementary Materials). This study outlines the invention of seven new transformations (Table ), but a vast array of new reactions is now conceivable.