Malignant melanoma is a form of skin cancer that has long posed difficulties to the oncology community, with few treatment options available and critical prognoses for patients with advanced illness. However, the recent introduction of innovative therapeutic tactics has changed the prospects of melanoma treatment, an example being chimeric antigen receptor Tcell (CAR T-cell) therapy. Malignant Melanoma has created a daunting situation for patients and professionals in the oncology community. Still, the development of advanced therapeutic approaches, such as CAR T-cell therapy, has progressed ideas and research in the treatment of melanoma.