It is possible to exemplify this by considering the top panel of Figure ; the most decisive variable in controlling particle size for water-based synthesis seems to be the HmIm concentration. On the other hand, Zn concentration seems to have a minor role when compared with Hmim. However, by looking at the pair plot diagonal (Figure ) it can be seen that Zn concentration has not been widely explored, rather the opposite. This limits the validity range for the Zn SHAP value interpretation; it might be the case that Zn concentrations play a major role in controlling particle size, but there might not be enough reported data corresponding to water-based synthesis, affecting thus the ML analysis. Despite the above discussion, the precursor's molar ratios have been explored up to 100 fold, and although critical to establish the mechanism behind ZIF-8 nucleation and growth, it seems not to be a critical parameter regarding particle size obtained. Although the influence of counterions in the Zn salt was scarcely explored, (Figure ), there are a few systematic reports in the literature that suggest an actual effect on the size and morphology of particles. Bias on temperature's role is also expected; by sorting out solvothermal synthesis conducted in hermetic vessels, room-temperature synthesis where mainly reported (with the associated variability of what temperature is considered room temperature in each case). The last point to be noticed is that time and stirring conditions seem not to play a significant role in controlling the final particle's size, although it has been reported that stirring conditions influence aggregation and polydispersity. In the case of methanol-based synthesis, both HmIm and Zn concentrations seem to have an equivalent relevance in determining the final particle size. When analyzing the distribution of reports for each variable (Figure ), it can be seen that, again, both concentrations have not been widely explored and that consequently, the explored molar ratio distribution is narrower than water-based synthesis. Distribution curves for stirring, counterions, and temperature conditions are also narrow, and showcase low SHAP values; time, however, has been extensively varied for both solvents, and yet its impact on particle size also seems to be insignificant. This is in line with the previous discussion regarding Ostwald ripening.