For future work, we envision the application of the present outlined approach in the investigation of spatial correlations in extensive organic systems, including proteins, nucleic acids, and other biomolecules. The ability to use coarse-grained MI to understand the structure of biomolecules underscores its utility in revealing how chemical groups interact and the strength of these interactions. As research in this area progresses, further refinements and applications of mutual information are expected to advance our understanding of molecular interactions and facilitate breakthroughs in various scientific fields.