Its observed that a single mutation in the Kelch-domain can incite significant dynamical fluctuations in the BTB-domain but it is not clear how the fluctuations of the individual residues are correlated with each other especially those are residing far apart. A proper understanding of the correlated motions can shed light on the long-range interaction patterns and eventually at the allosteric behaviors. To harness the correlated behaviors of the residues, we have performed the dynamical cross-correlation matrices (DCCMs) analysis by computing all the Pearson cross-correlation coefficients for the backbone Cα atoms of all the residues. The DCCM maps for the WT, Y493H and C580Y are graphically presented in Fig. as we have observed the fluctuations in these mutants. However, the DCCM map for the other two mutants is shown in Fig. .