The developed GNRs-QDs@NU-901 SERS substrate, presented a LOD for BA of 1.2 ppb when employing the fluorescence readout, which was surpassed by the SERS readout, with a LOD of 0.1 ppb. As a proof of concept, the GNRs-QDs@NU-901 paper was then mounted in a holder that collected exhaled breath (Figure ) and demonstrated the appearance of the Raman peak at 1620 cm -1 for LC samples (Figure -ii). After cross analyzing the samples with GC-MS (Figure -iii) and even performing PCA on the SERS readout, the authors demonstrated that the dual sensing with GNRs-QDs@NU-901 paper provide a suitable tool for the detection of VOCs from exhaled breath with no detriment on the analytical capabilities. There is an enormous variety of compounds in exhaled breath that can be employed for early detection of cancer, from lineal-and ramified-hydrocarbons, aldehydes, ketones, and aromatic compounds with different functional groups, from simple short-chain hydrocarbons to aldehydes, carboxylic acids, etc., and they can be found with different relative abundances in the range of 1-100 ppb. As it can be seen in Table , MOF-based SERS substrates can perform the detection of VOCs relevant for breath analysis with linear ranges and LODs well in range with the expected concentration range in real samples. In the table, the examples were classified according to SERS substrate carrying or with absent plasmonic metallic nanostructure component. This is to highlight the fact that Chemical Mechanism from MOFs is indeed a valuable contribution to the global performance of the platform, since it also allows to detect VOCs down to ppm levels. This can be seen for example when comparing the use of MIL-100 (Fe) MOF for toluene detection. If no plasmonic element is present, the LOD turns to be 20 ppm; however, when included, LOD reaches a value five orders of magnitude lower (0.48 ppm).