The orbital pair selection scheme is combined with multi-level DLPNO-CCSD(T 0 ), consequently referred to as pair-selected multi-level DLPNO-CCSD(T 0 ). While aiming at a target accuracy of either NORMALPNO or TIGHTPNO, the different accuracy levels are defined by specific pair cutoffs and PNO truncation thresholds that are separately treated in order to individually control the pair and domain approximation. Furthermore, the number of semi-canonical triples that have to be calculated can be reduced using a pair selection threshold that cuts off triples. The performance of this method is demonstrated for reaction energies of organometallic reactions from the WCCR10 set and for reaction energies and barrier heights of closed-shell organic reactions from the BH9 set. For fixed combinations of thresholds, accurate results were obtained using the def2-TZVP basis set for various reaction types and various system sizes, whereas the efficiency gain compared to DLPNO-CCSD(T 0 ) depends on the system size. As for the WCCR10 set, pairselected multi-level DLPNO-CCSD(T 0 ) can significantly profit from the locality of the reactions for systems with more than 40 atoms saving on average 63% of the computation time comparing the multi-level variant with a target accuracy of TIGHTPNO with TIGHTPNO DLPNO-CCSD(T 0 ).