When materials experience dynamic mechanical loading, such as during a high velocity impact, the resulting shockwave can generate a plethora of ultrafast thermal, mechanical, and chemical processes, including phase transitions , plasticity and failure , and chemical reactions . These processes are accelerated by energy localization into so-called hotspots. There is increasing evidence, from computational studies, that hotspots formed under shock loading react at rates significantly faster than equivalent ones taken to the same temperature and pressure states, but under equilibrium conditions . We have recently shown that a possible origin of this increased reactivity is the presence of highly strained and deformed molecules in the hotspot. This energy localization, in the form of intra-molecular potential energy, is persistent well into reaction timescales. The increase in strain energy in TATB is caused primarily by torsional and out-of-plane deformations of the nitro and amino groups, shown in Section S5 of the SI, and incurs a local amorphization of the material that affects kinetics and heat transport .