, . The results of our previous studies, predicted subnanomolar binding ranges for Triazine-cores branched with Trihydroxyl-Triphenyls 21 . However, those starshaped molecules tend to be highly hydrophobic and toxic. With the progression of the new Omicron variants, star-shaped molecules reducing any possible toxicity of those triazine core derivatives while preserving the cross docking to Omicron inner-cavity would be more desirable now.