Fig. Open database estimates of discovery output. The uppermost blue line, generated via WIPO PatentScope, uses the two International Patent Classification (IPC) codes of C07 and A61 that are selective for medicinal chemistry patents. The lowermost orange line uses the same IPC code select as the blue line but with the additional filter of having "University or Institute" in the assignee field. The grey line is a PubMed select for "inhibitor" and "drug" in title or abstract (the slope for inhibitor alone was similar).