Examples of molecules generated by this method are shown in Fig. . It can be seen that the addition and deletion of a few fragments from the starting molecule resulted in a molecule with improved QED values, while maintaining a high degree of similarity. One of the reasons for the higher similarity obtained with this method compared with MERMAID using SMILES is that the addition and deletion of fragments is limited to single bonds, thereby avoiding the direct editing of the ring structure as in MERMAID. However, this restriction of actions has a disadvantage in terms of diversity because complex rings cannot be generated (in the fragment-wise search).