-NTNV.dwam. A DW macro developed to automatically save, label and eliminate children molecules generated during any DW-BEL co-evolution which contained known Toxicity risks (Mutagenesis, Tumorigenicity, Reproductive Interference, Irritant) and/or any of the numerous Nasty Functions (see Nasty_functions.dwar). The NTNV macro uses *.sdf or *.dwar files as inputs, asks for user-renaming the input *.dwar file and renamed and saved the corresponding *.sdf file. This saving method supplied *.sdf files maintaining the 3D protein cavity docked to children 3D conformers for visualization in PyMol (using its split_states command) and/or maximal preservation of their 2D geometries for optimal consensus docking (Table ). More than ~ 3000 traded drugs were taken by DW as low toxicity reference (). Additional information on the DW Toxicity risks evaluated can be found at the Registry of Toxic Effects of Chemical Substances (RTECS) ().