Enzymatic elimination of mycotoxins is considered a promising method owing to its specificity, safety, and environmental friendliness 10 . However, effective mycotoxin-degrading enzymes are rare, owing to economic limitations and the potential toxicity of metabolic products 11,12 . In a previous study, we predicted > 550,000 enzymatic reactions involving biogenic toxins based on reaction rules 13 . Although these reactions could potentially eliminate mycotoxins, ~94.7% of these have not been experimentally verified owing to the long verification period and high experimental costs of traditional enzyme-mining methods based on microbial screening and functional metagenomics 13 . To date, 4 × 10 9 proteins have been sequenced, and with the rapid development of proteomics, the number of known proteins doubles every 24 months 14,15 . A framework for the rapid and high-throughput prediction and verification of new enzymes with desired activities, e.g., mycotoxin degradation, is urgently required.