Upon the excitation of trans-resveratrol, one possible isomerization product is cisresveratrol. As noted in the Introduction, the formation of cyclization products such as THP is well-documented, along with the photoreaction product resveratrone. The present study aims to clarify whether any compounds obtained after trans-resveratrol excitation can participate in singlet oxygen generation reactions. Thus, the photophysics of trans-resveratrol, cis-resveratrol, THP, and resveratrone was studied in implicit solvent and with explicit (micro) solvent plus implicit solvent. As discussed elsewhere, microsolvation is essential for describing excited state dynamics and the efficiency of photosensitizers in water, especially in cases where strong hydrogen bonds with the chromophore can be formed. Thus, these results should be considered our most accurate predictions.