In all combinations, there is a local minimum at score 37.7 that separates the distribution into the 2 major conformational modes. The percentage of docking runs per the total in each combination is given in Table . In each set of different radii of computational docking, S197 (resistant) and P197 (susceptible), the percentages in the 2 conformations remains about the same, but the percentages are different across the 2 types P,S of sequences. In the susceptible strain P197, CS binds equally as much in both conformational modes, and in the resistant S197 strain, it binds significantly more to the 2nd less energetic mode by 3:1. The cavity has changed both in surface geometry and amino acid content/interactions and this is reflected in the difference from S197 to P197. A more refined view of the set of 500 radius 4 scores, the distribution, is in Figure . For example, the relative population in the highest binding mode substantially decreased 3-fold (Table ), and a new low scoring binding mode with splitting opens at score 32. The conformational make-up of bound CS is visibly seen to change much from P197 to S197. scoring binding mode in the resistant S197 AHAS has been almost eliminated from that in the natural P197 strain; the population fractions in Table quantify the overall extent. This can be seen at radii 4,7, and 15 when the y-axis scale is taken into account. A more detailed quantitative analysis is given next.