Watson-Crick base pairing between complementary nucleic acid sequences is one of the most important fundamental processes of molecular recognition in vivo, such as during DNA replication and transcription of genetic information . Nucleic acids also play a crucial role in sensing applications by acting as molecular recognition elements to offer high specificity , and as reporters to generate a detection signal . The advantages of nucleic acids include their biocompatibility, modular structure, ease of synthesis, and ability to be chemically modified in a sequence-defined manner . Spherical nucleic acids (SNAs) consist of a nanoparticle core that is densely functionalized with nucleic acids . One notable features of SNAs is that the dense and oriented nucleic acids on surface exhibit higher affinity for their complementary sequences in comparison with the free nucleic acids in solution .