The phylogenetic tree of the seven polyproteins is shown in Fig. . The two parts of the Main protein from the whole genome of the SARS-CoV-2 aligned with two SAR proteins and the ligand binding sites were similar, the alignment positions, number of amino acids and ligand and the interacting residues is given in Table 3 The polyprotein also has an identity of 19.74 percent with an ABC-type uncharacterized transport system periplasmic component-like protein, this protein is known to be a substrate binding protein and possible binding can be explored here .