Unfortunately, the admonition to maintain correct asymptotic behavior of υ xc (r) is not always heeded. When orbitals from a semilocal or a global hybrid functional are inserted into wavefunction-based SAPT0 formulas, the too-small energy denominators (resulting from HOMO/LUMO gaps that are much smaller than those in HF theory) cause E (2) disp to increase unrealistically. This is the reason why SAPT0(KS) was abandoned soon after the first numerical experiments in the early 2000s; it was not resuscitated until the use of optimally tuned LRC functionals became commonplace. Meanwhile the SAPT0(B3LYP) method, meaning Eq. ( ) with B3LYP orbitals, was the lone example of the SAPT formalism to be considered in a comprehensive survey of contemporary EDA methods for protein-drug interactions. From that unfair comparison, the authors concluded that DFT-based EDAs offered a better balance of properties, 108 without considering the fact that such an approach exacerbates the already too-large dispersion energies predicted by SAPT0(HF) calculations.