Moreover, the reactions were first attempted at room temperature at which a thick heterogenous slurry formed and rendered the mixture difficult to stir. However, as temperature was increased to 45 °C, the mixture was homogenous, easy to stir and filter which ultimately afforded the desired purity. The optimized process described above was demonstrated to be repeatable in more than 20 experiments varying in scale from 15 grams to 500 grams. A 4,7-DCQ yield of 81% and purity of more than 97% were achieved throughout. This process resulted in an overall yield of 68% of the correct quality 4,7-DCQ. Based on this, a material cost per kilogram for 4,7-DCQ was calculated as $24.17 versus a market price of $42.00/kg. The material margin of the process at current market prices is slightly better at 42% versus the target material margin of 37% specified in the scope of this project. That said, successful development of a cost-effective, competitive process for production of 4,7-dichloroquinoline (5) would mitigate the reliance on imports and provide a steady supply of this critical intermediate.