Resiniferatoxin is a capsaicin analog, and both resiniferatoxin and capsaicin bind to TRPV1 and desensitize it through calcium cytotoxicity. Resiniferatoxin is 3 orders of magnitude more potent than capsaicin in pain relief, thermoregulation, and neurogenic inflammation . This is because resiniferatoxin binds to TRPV1 for a prolonged period of time, allowing more calcium cations to flow through than capsaicin does.