Figure describes the overall EVP statistics of the substitution patterns around the indole dataset we consider here. Figure shows the probability of coverage of each exit vector for the indole scaffold. According to Figure , the most commonly substituted vector is R2 (usually referred to as the 3-position for indoles) where electrophilic aromatic substitutions occur most preferentially in indoles, while R1 and R4 are the least commonly substituted positions. Figure shows the degree of exploitation (dEVP, i.e. the number of substituted positions) for the series of indoles, with di-substituted derivatives being the most common. From this information, we can determine the coverage of structural diversity within the indole dataset.