Mitochondrial DNA replication is extremely important as the mitochondrial genome encodes essential components for oxidative phosphorolysis and energy production. The replication of mitochondrial DNA is mediated by polymerase (pol ) . Pol  is classified under the A family of polymerases, and possesses both replicative as well as editing functionality, providing high-fidelity replication and repair of DNA. This is crucial, as errors can lead to mutations associated with various diseases, including neurodegenerative disorders and other metabolic syndromes, as well as loss of catalytic function .