Here, we choose the convenience of the "grafting to" method. The polypeptoids feature a hydroxyl (-OH) group on the side chain of the first monomer at the C-terminus (Figure ), providing strong binding to oxide surfaces like activated SiO2 with silanol groups. Five hydroxyl-terminated polypeptoid 21-mers (PP1 through PP5, Table ) were designed and synthesized with a combination of polar and non-polar monomers to adjust hydrophilicity and other properties impacting processability, such as solubility in organic solvents, crystallization inhibition for spin coating, as well as compatibility with liquid chromatography characterization.