Finally, atom-typed force fields do not easily generalize to diverse chemical environments. Examples in the literature involving refitting atom-types for a specific chemical environment are often time-consuming and rarely apply far outside of the limited set of atom-type parameters under consideration. This owes to the proliferation of often redundant and complex atom types that arise around new chemical moieties. As such, the combinatorially large chemical space of novel polymers and biopolymers with non-canonical monomers requires a more systematic approach to identifying chemical environments. Although atomtypes work well for well-defined systems like proteins, the development of general force fields requires a workflow that more easily generalizes to any chemical environment.