In cases of chronic venous insufficiency, alterations in fluid dynamics disrupt nutrient delivery and waste removal, leading to venous ulcers and significant changes in skin texture and elasticity. Such disturbances not only contribute to disease progression but also impede the body's natural healing processes. In conditions like eczema, altered chemical transport and reaction mechanisms lead to a disrupted skin barrier, resulting in increased trans-epidermal water loss and susceptibility to allergens . Similarly, in diabetic ulcers, compromised bulk flow and impaired diffusion of nutrients and oxygen contribute to poor wound healing and biomechanical instability .