The synthesis of BSBCz derivatives was performed using the Chemspeed SWING XL automated platform, available at the University of Toronto. For more details of the automation manager for the Chemspeed platform, see Note S3. Automated Suzuki-Miyaura couplings were performed following the general slow-release conditions reported by Grzybowski, Burke and coworkers. Synthesis instructions were received from the SiLA2 client on ChemOS 2.0. Reactions were performed in the ISYNTH reactor under a nitrogen atmosphere, established by five evacuate-backfill cycles. Reactants and reagents were transferred as stock solutions in 1,4-Dioxane or water, respectively under a constant stream of nitrogen, using the 4-Needle liquid dispensing tool. The reaction mixture was heated to 100 °C under vortex stirring for 12 h. The reaction mixture was cooled down to room temperature for 1 h, and the crude reaction mixture was filtered over a short plug of celite (using the Solid Phase Extraction module of the Chemspeed SWING XL platform), eluting with tetrahydrofuran and collecting the eluate. Following communication with the HPLC-MS device through the respective SiLA2 client on ChemOS (details see below), the eluate is automatically injected to the HPLC-MS using the on-deck injection valve equipped with a sample loop.