In 2016, our group reported an oxyalkynylation reaction of diazo compounds using EthynylBenziodoXolones (EBX) or their derivatives and a copper catalyst. Later, enantioselective variation of this reaction were developed using BOX ligands. Trifluoromethylated diazo compounds were not used in these early works. Interestingly, despite copper being one of the most earth-abundant transition-metal catalysts, it has been only barely used in carbene-based enantioselective MCRs. Recently, we could extend the use of copper catalysis to a 3-CR reaction between modified EBX derivatives, diazo compounds, and nucleophiles, such as alcohols or anilines. For the first time, trifluoromethylated diazo compounds could be used. However, the development of an enantioselective method has not yet been reported.