Diffusion within the integumentary system is facilitated by various skin appendages including the glands and hair follicles. Sweat glands release substances like electrolytes and some waste products, which alters the concentration and influences diffusion. Sebaceous glands secrete oils that may facilitate the transport of certain lipid-soluble substances. Hair follicles provide pathways for the penetration of chemicals through their associated sebaceous glands. The absorption of pharmaceuticals through the skin relies on diffusion, where drug permeability through the stratum corneum is a key factor affecting their efficacy . Chemical reactions, including enzymatic activities and oxidative stress responses, further modulate transport, often exacerbating tissue damage and disease progression . Reactions such as enzymatic breakdown or metabolic conversion can influence chemicals' biological effects and toxicity, creating a complex interplay between transport and pathology . Thus, in pathophysiological states, such as inflammatory skin diseases, diffusion mechanisms are altered, leading to an imbalance in ROS and other metabolites.