PMT/vPvM substances have been suggested to have an equivalent level of concern as persistent, bioaccumulative and toxic (PBT) substances or very persistent and very bioaccumulative (vPvB) substances. GenX and perfluorobutane sulfonic acid (PFBS), both classified as PMT/vPvM substances by the German Environmental Agency (UBA) (but not yet officially classified under the CLP Regulation), have been identified as substances of very high concern (SVHCs) under the European Registration, Evaluation, Authorisation and Restriction of Chemicals, REACH, regulation . The commonality between PMT/vPvM and PBT/vPvB substances is their elevated potential for long-lasting and long-range exposure when released to the environment in substantial quantities. Their difference is related to the exposure pathway, with PMT/vPvM substances likely to be first monitored in water resources where they are most likely to accumulate and PBT/vPvB substances being first monitored in the food supply, humans and living organisms. Though this was not stated within the CLP regulation , it may be assumed this was introduced due to concerns from enhanced exposure potential leading to unforeseen effects, be they odour, aesthetic, geophysical, economical or other than established toxicological criteria. As an example, REACH Annex 1, Section 0.10 refers to "particular effects, such as ozone depletion, photochemical ozone creation potential, strong odour and tainting, for which […] the risks associated with such effects shall be assessed on a case-by-case basis". Considering these concerns, a key consideration for vP substances is to further check if they exhibit enhanced exposure-related properties (vB or vM), toxicological or other hazards, following the current regulatory approaches.