Just because two drugs share a common pathway does not mean that the two individual drugs are even in the same arm of the pathway with common effects to be seen downstream. In an attempt to have a set of combinations only with two drugs sharing a common interaction stream, a different approach was specifically done to have only combinations which share common effects if targeted (Figure ). This network has 6449 edges and 648 nodes. At a limit of 4 interactions allowed between the two drug targets, the number of pottential synergies is 1089. The directional method produced a similar number of potential combinations as the shared pathway approach but in the directional method, there is increased confidence about the targets having a common path that connects the two and more confidence in their relation to each other biologically.