Figure shows the percentage of unique Bemis-Murcko scaffolds in each of the 11 libraries. The analysis revealed that TocrisScreen is the set with the largest percentage of unique scaffolds (85.6 %), indicating a large scaffold diversity considering the definition of the scaffold of Bemis-Murcko. The library with the second largest percentage of unique scaffolds was Targetmol (82.3 %). Figure shows the percentage of scaffolds with a frequency of at least two per library. Clearly, ChemDiv was the data set with the largest proportion of non-unique scaffolds suggesting the lowest scaffold diversity.