Following a previous work by the authors on the atomistic modeling of PLGA and PEG , first a coarse-grained model for PLGA was defined. This polymer, which is extensively used within the drug delivery and nanomedicine community, is represented as a sequence of dimeric units of lactic and glycolic acid monomers (LA/GA 50:50), with LA in alternated L and D configurations. Invoking standard MARTINI parametrization v2.2, three possible CG dimeric blocks were considered, namely Na-Na; Na-N0; and P1-C5. To identify the best dimer block, the PLGA solubility in octanol, water, and acetone was assessed for all three configurations above and compared with the results at atomistic resolution. Specifically, the free energy of transfer DG from acetone to water (DGPPN-W) and from octanol to water (DGO-W) for the three CG models were compared with the same energy values calculated with the united-atom (UA) model GA-LA2016H66. Data are tabulated in Figure showing that the Na-Na dimer block returned values that are closer to the atomistic model as compared to the other two CG models.