The small molecule PROTAC AT1 21 was chosen as the guide for OligoPROTAC design. AT1 shows selective BET bromodomain protein, BRD4, degradation and suppression of tumor growth in AML . AT1 comprises of the widely used and well-characterised binder of BET bromodomain proteins, (+)-JQ1 , as its POI-targeting warhead, and the VH032 ligand, for recruiting the VHL E3 ligase complex . To create the OligoPROTAC, we aimed to attach VH032 to the 5'-terminus of one DNA oligonucleotide and (+)-JQ1 to the 3'-terminus of a complementary DNA oligonucleotide. Thus, by hybridising the two DNA strands, the VH032 and (+)-JQ1 PROTAC warheads would be positioned in close proximity on the same end of the double strand (Figure ).