Unlike the Zaitsev elimination, in which analyses of alkene substitution can afford the correct conclusion, there is not a lone heuristic for the Markovnikov addition and Hofmann elimination. The Markovnikov reaction is kinetically favored, but the products have roughly the same thermodynamic favorability. With the Hofmann elimination, the less substituted 300 alkene, the less thermodynamically favored product, is formed as the major product.