The aim of the SAMPL8 challenge is to assess quantitative accuracies of current methods and isolate deficiencies with the advantage of access to a larger database of pharmaceutical compounds provided by GlaxoSmithKline, which created a comprehensive data set to be used for evaluating new prediction methods. In this study, research was focused on creating a standard data set of solubility-based pKa and pH-dependent distribution coefficients for various immiscible solvent combinations by exploiting laboratory automation and HTE.