MADS-box (PS50066) is a MADS-box domain. This domain encompasses mammalian myocyte-specific enhancer factors 2A to 2D (MEF2A to MEF2D). Animals'muscle development and cell proliferation and differentiation are associated with MADS-box genes. The motif CC[A/T] 6 GG, also known as the CArG-box, is highly similar to DNA sequences that MADS domains bind to.