The next phase of the development is to implement a robust crystal picking algorithm for fully automated 3D ED data collection and analysis . The current crystal picking function implemented in Instamatic is based on analysing the contrast in micrographs. In order for the algorithm to work, continuous carbon supporting film is necessary. Recent development in artificial intelligence, like those implemented for particle picking in single particle analysis , provides new opportunities for more robust crystal picking. It will further improve the throughput of 3D ED data collection, completely remove bias in crystal picking and enable unsupervised phase analysis.