T cells are involved in fundamental processes in viral infections. CD8 T cells eliminate infected cells and CD4 T cells help B cells for antibody production. Nevertheless, immunopathology is generated when T cells are dysregulated. Several reports have shown that moderate to severe COVID-19 patients with lymphopenia drastically reduce CD8 T cell and CD4 T cells in peripheral blood . T cells reduction in the blood is also a contribution of mechanisms such as inflammatory cytokine milieu, which is why lymphopenia has a correlation with TNF-α, IL-6 and IL-10 88,89 . Conversely, clinical reports have shown that convalescent patients have low pro-inflammatory cytokine levels paired with restored bulk T cell frequencies .