The extensible GMBE algorithm described in Section II has been implemented in Fragme∩t, a new Python-based application designed for fragmentation calculations. It succeeds a C++ code of the same name that was developed in our group over many years and used in previous (G)MBE studies. The new Python application has already been used to obtain converged thermochemical quantities for enzyme- Fragmentation workflow as implemented in Fragme∩t. Once the supersystem's geometry has been loaded and split into primary fragments, it is passed to Fragme∩t's main loop, which iteratively proposes new auxiliary fragments. These may or may not be added to the PIE-DAG, depending on the outcome of the screening procedure. New fragments and PIE metadata are stored in a SQLite database. Electronic structure calculations are run in parallel and are also stored in the database. catalyzed reactions, though only non-covalent fragmentation is considered in the present work.