Runtime. The runtime for the methods discussed here differ considerably: Generating the KLIFS seq dataset takes about a second (based on about 500 kinases), while the KLIFS IFP dataset is ready within half a minute (based on about 8800 IFPs); both procedures build on the processed and curated KLIFS datasets, i.e. both the pocket sequences and the pocket interaction fingerprints are ready for use. Generating the KiSSim kinase matrix takes about 24 hours, while the all-against-all comparison with SiteAlign is ready after > 20000 hours using the optimized SiteAlign settings (both based on over 4000 structures and a single-core/thread execution). Parallelization is built-in for the KiSSim approach to speed up the calculation.