These issues highlight an important advantage of the presented approach, namely its extendable design. At the technical level, the LC-MS/MS system is still far from working at full capacity, as it still holds the potential of the inclusion of hundreds of additional mass spectrometric transitions. With future advances concerning the knowledge of emerging toxins or relevant biotransformation products as well as the availability of appropriate analytical standards, each compound category might be further expanded with additional markers of exposure or direct biomarkers of biological effect. While measuring the 'entire exposome' by a single analytical method or platform will not be feasible, we see the presented approach as an ambitious attempt to cover a vast chemical space that can be further expanded.