and B (59), ochlephilone (14), isochromophilone IV (11) and isochromophilone J (13) displayed effects on Amaranthus retroflexus L. Sclerotiorins A (58) and B (59) showed strong phytotoxicity against radicle and plumule formation, while ochlephilone (14) exhibited growthinhibiting properties against velvet leaf. ). Penicillium sclerotiorum emerges as a significant source of compounds holding economic potential, particularly in the food industry. Its diverse range of derived pigments not only offers natural alternatives to synthetic colorants but also presents versatile applications across various sectors, showcasing its potential as a valuable resource for sustainable and multifaceted solutions.