The main disadvantage of PSYCHE is that it must be acquired as a pseudo-2D experiment via interferogram acquisition. A series of Free Induction Decays (FIDs) are acquired, and only the first "chunk" of each FID, where the homonuclear J is refocused at its center, is stored. Each chunk is concatenated to form a new "pure shift" FID. The periodic discontinuity of the interferogram FID causes pronounced artifacts, especially in the case of intense signals such as the water peak in aqueous samples. PSYCHE-SAPPHIRE (Sideband Average with Periodic PHase Incrementation of the Residual J Evolution) can be used to suppress these chunking artifacts, including those arising from the incompletely suppressed residual water peak. This was recently demonstrated by Here, we illustrate two new experiments that combine PSYCHE-SAPPHIRE and water suppression by internally encoding either Excitation Sculpting (iES) or WATERGATE-5 (iW5) elements into the original SAPPHIRE pulse sequence. This simple approach eliminates the need for long recycle delays used for the pre-saturation and increases signal-to-noise per time unit relative to experiments based on presaturation. Figure shows a comparison between these new methods with others from the literature for a sample of bupivacaine hydrochloride in 9:1 H 2O/D2O (v/v). Analyte signals were obscured in conventional (Fig. ), and TSE-PSYCHE-ES (Fig. ) experiments due to the intense water peak at 4.68 ppm. In the PSYCHE experiment, periodic chunking artifacts heavily distorted the baseline and significantly attenuated the signal at 4.17 ppm, proximate to the residual water resonance. The recently introduced PSYCHE-NOESY-pre-saturation (Fig. ) experiment exhibited good performance for water suppression and homonuclear decoupling. Still, a significant reduction in signal-to-noise ratio (SNR) per unit time was observed due to the long pre-saturation recovery times. Both SAPPHIRE-iES (Fig. ) and SAPPHIRE-iW5 (Fig. ) preserved signals near the water resonance, with the latter yielding nearly complete solvent suppression with minimal baseline distortion. Both also provided a sensitivity improvement (1.4x and 2.6x, respectively) compared to the PSYCHE-NOESY-pre-saturation (Fig. ).