Many areas of the body are not accessible to large bioelectronic devices and implanted electrodes; therefore to fully exploit electricity as a therapeutic pathway we require novel means of approach to the design and manufacture of bioelectronics for real application. Liu et al. highlighted the need for bioelectronics to be redesigned: being 3D rather than planar, with micro/nanoscale feature sizes and comparable or softer mechanical properties than biological tissue. Microfabrication methods, such as inkjet and screen printing, have been adapted using novel biomaterials to create soft, flexible electronics. This has allowed skin-like electronics to be produced for novel applications such as tattoo sensors, neural interfaces, and in vivo electrochemical sensing of analytes such as cell metabolism. This offers exciting possibilities for biosensing and wearable technology, however for, in vivo bioelectronic applications, soft electronics would still require implantation and provide only a 2D interface with biology.