The DLPNO-CCSD(T) energy calculations for the 1350 reaction in CRN-E enabled us to obtain 2700 forward and backward reaction rates constants for the reactions of 595 compounds in the network. Figure shows the unimodal exponential distribution of reaction rate constants according to their activation energies as confined by the initial boundary conditions of the CRN exploration. The distribution covers a range of approximately 250 kJ•mol -1 , which is equivalent to 44 orders of magnitude in reaction rate constants. The peak of the distribution is roughly at 25 kJ•mol -1 and the majority of reactions have an energy of <80 kJ•mol Consequently, most reactions have a half-life of 12 seconds at room temperature according to the Eyring equation. We have divided the reaction types in three main groups according to whether the stoichiometry of the reaction (i.e., ν reactants -ν products ) is positive (indicative of an association reaction), negative (dissociation) or zero (bond rearrangement). Table 1 shows that CRN-E has 1710 associations, 520 dissociations and 470 bond rearrangements.