Following the good control of the acidity reaching very high concentrations of protons, we disposed the generation of acid to deprotect acid labile groups employed in solid phase synthesis. We tested Boc protecting group, known in peptide and nucleotide synthesis due to the high yield of polymers that it achieves. However, the high yields of purity achieved are also due to its stability that ensures the orthogonality of the chemis try during acid/base transitions and which requires a high acid concentration for its removal (~50% TFA in DCM used in many traditional solid phase synthesis).