We decided to compare the results for the disaccharide Glcα(1→1)Glcα (trehalose) with the previously published Martini 3 trehalose parameters (Supplementary Table , Supplementary Figure ). The modelled constraints (i.e. bonds that define a cycle) display a systematic shift between 0.02-0.03 nm towards larger values for the original Martini 3 parameters with respect to the new parameters, due to the bond length scaling for the bonds that define the rings. The bond between both monomers also shows a clear shift between both models, with a ~ 0.06 nm larger average value for the new Martini 3 respect to the original one. Nonetheless, there was excellent agreement for the dihedral distribution (with a reference overlap of 0.93) and good agreement for all the angle distributions (spanning overlap values of 0.63-0.88). Finally, the SASA distribution showed good agreement with an overlap reference value of 0.6. Furthermore, we decided to compare the distributions of Glcα(1→1)Glcα and Glcα(1→1)Glcβ to assess the effect of the orientation of the OH group in the anomeric carbon. It is clear, that in this case, where the glycosidic bond is established between two C1 atoms, the coarse-grained model is sensitive enough to discriminate between anomers, showing clear differences in the distributions of angles, the glycosidic bond and the dihedral (Supplementary Table , Supplementary Figure ).