Blind community wide-challenges such as the Drug Design Data Resource (D3R) Grand Challenge and the Statistical Assessment of Modeling of Proteins and Ligands (SAMPL) () provide an excellent platform for developers to test and validate their computer-aided drug design methodologies against experimental datasets. Moreover, the unbiased setting of these challenges allows the participants to compare the performance of their workflows and techniques to other computational methods in the field, thus highlighting potential areas of enhancement.