Our early datasets were restricted to molecules with 12 atoms or less and were based on CCSD(T) energies. We have established a repository "QM22" of these datasets. These extensive datasets allows one to employ PIP PESs for quantum calculations by means of approaches like diffusion Monte Carlo, VSCF/VCI, and semiclassical dynamics. Examples of such calculations include glycine, ethanol, and ethylene glycol 44 gaining interesting physical insights and providing excellent accuracy compared to experimental data.