For the forward model, the coefficient of determination for difference in synthetic accessibility was a modest (R 2 = 0.81), and a weak (R 2 = 0.24) for difference in molecular complexity. While the overall distribution of differences in these metrics was similar for predicted and literature reactions, there was a notable peak in predicted reactions with a ∆Cm between zero and fifty and a ∆SA beteween zero and ten. The retrosynthetic predictions had a very low coefficient of determination for ∆SA (R 2 = 0.0021) and a moderate coefficient of determination for difference in molecular complexity (R 2 = 0.11). While Figure shows that predicted retrosyntheses have both positive and negative deviations in both synthetic accessibility and molecular complexity from that of the literature reactions, the distributions of change in both metrics did show a slight shift towards more negative values. If all other factors are equal or comparable, be it reaction yield, reagent cost, stereo-or regioselectivity, these alternative routes could aid in reducing bias in organic synthesis and provide novel variation in areas where human experimenters may be "stuck in a rut".