The systematic and hierarchical crystal packing approach (see Method Summary section) provides a significant efficiency improvement as compared to the stochastic approach employed by other CSP methods. Most groups participating in the 7th CSP Blind Test used methods that parameterize the search space via the six unit cell lattice parameters, the six parameters for ASU location and orientation, and the conformational degrees of freedom, and search these degrees of freedom simultaneously. These methods require substantial computational effort to adequately cover the search space due to the size and complexity of the parameter space.