Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) and CRISPRassociated proteins (Cas) have revolutionized the field of genetic engineering and therapeutic development. Originally discovered as an adaptive immune mechanism in bacteria, CRISPR/Cas systems have been harnessed to enable precise and efficient genome editing in a variety of organisms. This powerful technology offers unprecedented opportunities for advancing our understanding of genetic diseases, developing novel therapies, and potentially curing previously intractable conditions.