Synthesis and crystal growth. The solvothermal synthesis of HTBZ-SAC, HTBZ-HMA, and HTBZ-HOX yielded high-quality single crystals suitable for SC-XRD. Despite our best efforts, HTBZ-HFU crystallized as microcrystals, and its structure was solved directly from PXRD data. Solvothermal methods require large amounts of solvents and involve a time-consuming crystal growth process. As an appealing alternative for industrial and large-scale applications, solid-state synthesis has gained attention . Figure displays the PXRD patterns of products obtained through the mechanochemical treatment of equimolar quantities of TBZ and each acid. It is worth mentioning that although milling is an optimal strategy for scaling the production of salts and cocrystals, it has some disadvantages, including probable contamination , amorphous content which may be undesirable side-product , particle size variation, and other technical challenges.