Flow injection analysis (FIA) is a high-throughput analysis method in which samples are injected sequentially into a flow of carrying buffer upstream of an electrochemical detector . FIA paperbased devices driven by capillary flow have been reported for the analysis of small molecules in buffer or urine samples, using electrodes contacted to the paper surface . In comparison, our LIG-E approach offers two main advantages. First, it simplifies the device architecture by integrating the fluidic channel and electrodes together, and second, it analyses the entire cross-section of the fluid flowing through the channel and not just the fluid in contact with the top surface.