We used the local MEME program to examine the similarities between the sequences of the HIV1 envelope glycoprotein GP160 and the monkeypox virus E protein F13. Table shows the results of the search for the GP120 domain in the monkeypox virus E protein F13. Envelope glycoprotein GP160 is cleaved by HIV-1 into the surface protein GP120 and the transmembrane protein GP41. For HIV infection to take place, viral GP120 must bind to CD4 glycoprotein and chemokine receptors on cell surfaces, respectivelys . The F13 protein contains all two functional sections of the GP120 domain of monkeypox virus E. In this context, it is important to note that the F13 protein plays a pivotal role in receptor binding. Therefore, the monkeypox virus E protein F13 combined with a receptor similar to HIV1 GP120.