In summary, T. maritima is able to synthesize all natural 5'-(deoxy)NTPs starting from the respective (deoxy)NMPs, although it does not possess an NDP kinase (Figure ). The majority of NMP kinases as well as TmAcK and TmPK are able to phosphorylate NDPs to NTPs. Furthermore, TmPPDK either converts (d)AMP to (d)ATP or (d)ADP and (d)GDP to the corresponding (d)NTPs. Due to the presence of the wide-spectrum TK and the RK, phosphorylation of deoxynucleosides and uridine to the respective monophosphates is possible. A nucleoside kinase for the synthesis of riboNMPs, however, seems not to be present in T. maritima (Figure ). Though, in purine metabolism enzymes of the complete de novo pathway are present, so that the synthesis of AMP and GMP is possible via this route (Figure ). In addition, the genome of T. maritima also contains phosphoribosyltransferase (PRT) for adenine and hypoxanthine which catalyze the synthesis of AMP and GMP starting from the corresponding bases. However, based on the available data, the synthesis of CMP starting from cytidine or cytosine is not possible in T. maritima, since corresponding enzymes are missing (Figure ). Though, probably the salvage of CMP is catalyzed via TmNuc or deamination to uridine by cytidine deaminase.