For most applications, MOF design is guided by multiple target objectives, or by the satisfaction of certain constraints. Continuing with the theme of MOFs tailored for carbon capture applications, there are several properties one might be interested in optimising simultaneously. A prime example is DAC, where the atmospheric CO 2 concentration (∼400 ppm) presents a significant challenge. At these concentrations, chemisorbents (which selectively bind the adsorbate through chemical bond formation) are traditionally favoured due to their strong interactions with CO 2 (Q CO 2 > 40 kJ mol -1 ). However, MOFs as physisorbents for DAC have become an attractive alternative to chemisorbents due to their more modest sorbent regeneration requirements. In most cases, the interactions with CO 2 in these materials are relatively weak (typically less than 30 kJ mol -1 ), resulting in low CO 2 uptakes at the relevant process conditions. Hence, one design objective at the material level is to maximise Q CO 2 . At the same time, the MOF should be selective to CO 2 over other gaseous components in the air such as N 2 and H 2 O. This leads to a dual design objective: maximizing both the Q CO 2 and the selectivity of CO 2 over gases such as, for example, N 2 (i.e., S CO 2 /N 2 ).