Figures and illustrate, respectively, the correlation between the unique EVP and the dEVP with pChEMBL value, as a measure of compound activity. Of note, we consider compounds as active when the pChEMBL value is greater than 7, corresponding to a Ki of 100nM. EVP [2,3,5,7] has the highest observed median pChEMBL value (around 7.15) and the most recurrent EVP [2,5,7] has a median pChEMBL value of 6.5. Figure , confirms that compounds with 4 substitutions, such as [2,3,5,7], have the highest median pChEMBL value. Amongst compounds with 3 substitutions, EVPs [2,5,7] and [2,3,5] overall have the lowest median pChEMBL value. Although these observations do not take into account the nature of the functional groups at each exit vector, which influence the individual compound activity, these plots represent an effective way of visualizing scaffold substitution patterns.