Depending on the arrangement of the panels around the cage; the diastereomers obtained thereafter can result in contrasting guest-binding affinities to the hosts. While the cage constructed using a 1,6-pyrene scaffold offers an adequately isolated microenvironment for effective binding for large aromatic (coronene, perylene, pyrene triphenylene) and hydrophobic guests (C60 and C70), the 2,7-pyrene-edged cage fails to encapsulate these neutral guests due to its insufficient enclosure, which limits its ability to confine potential guests within its cavity.