While prior theoretical study by the Shaik group showed that fluorinated alcohols increased the epoxidation reaction rate , the studies by Berkessel explicitly showed the effect of multiple aggregates of the solvent molecules. Later, Steenackers et al. experimentally studied the epoxidation of βcaryophyllene to caryopyllene oxide in aqueous H 2 O 2 , alcohols, nitrogen containing solvents, and furans (11 solvents in total) . In all cases, the rate correlated extremely well with Abraham's hydrogen bonding parameters (R 2 = 0.97), and interestingly, not well at all with the dielectric constant (R 2 = 0.17), as shown in Figure . They further characterized solvent effect using ωB97XD/g-311++G(df,pd) and IEPCM. This computational investigation confirmed previous studies that the solvent stabilizes the O-O bond in H 2 O 2 in the transition state structure via hydrogen bonding .