As exogenous compounds to the human body, polyphenols are included in the exposome, i.e. the total burden of exposure of an individual in a lifetime and its health related effects . Currently, different exposomic approaches are used to better understand and quantify the complex exposure of xenobiotics in humans. These approaches typically utilize liquid chromatography coupled with mass spectrometry (LC-MS) in two distinct acquisition strategies . The first, called traditional human biomonitoring or targeted, focuses on acquiring LC-MS data for only specific known analytes of interest using available reference standards . The second strategy, known as untargeted, involves acquiring spectrometric data on all compounds that can be ionized and are sufficiently abundant . The untargeted approach can be split into suspect screening, which involves identifying the unknown chemical features by matching various parameters (e.g. monoisotopic mass) with compounds of interest present in databases; and into non-targeted analysis, which includes various techniques such as annotation by in silico fragmentation and/or finding relevant features by statistical analysis .