(1/10 μM) were incubated at 37 °C with 5 mM GSH in 100 mM potassium phosphate buffer, pH 7.4 (0.1% DMSO). The analytes were separated with ACQUITY UPLC BEH C18, 1.7um 2.1 * 50mm Column (Part No.186002350), and the mobile phase consisted of 0.1% formic acid in water/acetonitrile with a linear gradient of organic phase. Samples were then analyzed with an LC (Shimadzu LC-40)/MS/MS (Triple Quad 6500+). From the mass spectrum, peak area ratios (peak area analyte/peak area of a stable internal standard) were calculated and the percent compound remaining was determined relative to time zero. Rate of disappearance of analyte (ke) and half-life (T1/2) were calculated by 8itting to a pseudo-8irst-order kinetic equation 𝐶 ) = 𝐶 + * 𝑒 ,-! * )