Due to the low toxicological profile and affordability, Polyoxyethylene cetyl ether (Brij 58: HO-(CH2CH2O)n-(CH2)15-CH3, n~58) and Polyoxyethylene stearyl ether (Brij S20: C18H37(OCH2CH2)nOH, n~20) are often employed as emulsifiers, surfactants, and excipients in a variety of bioformulations . Brij is a polymeric, biocompatible, non-ionic surfactant with self-assembly property . Brij molecules have a hydrophilic head and a hydrophobic tail, making them amphiphilic . Above critical micelle concentration (CMC) Brij spontaneously forms micelles that can solubilize substances with low water solubility through hydrophobic interactions/H-bonding because of their lipophilic core and hydrophilic surface . Moreover, micelles produce steric hindrance, which restricts the drug's interaction with the surrounding environment and maintains the entrapped drug's stability over time.