The effect of PCL fibers on clot formation in normal and uremic toxin loaded plasma was assessed using theplasma recalcification turbidimetric assay (Figure ).It is important to note that surface area has a large effect on the kinetics for this assay, where higher surface area leads to increased overall kinetics for clot formationinitiated via the surface contact pathway. Clot kinetics are rapid for this system, likely due to the high surface area afforded by the fiber mesh.