The curation process of the new NPs added to LANaPDB was the same as that implemented in the first version of the database. The process was carried out in the Python programming language (version 3.10.7), employing the RDKit (version 2022.03.5) and MolVS (version 0.1.1) modules. The standard curation process of MolVS was implemented: removal of explicit hydrogens, disconnection of covalent bonds between metals and organic atoms (the disconnected metal is not preserved), application of normalization rules (transformations to correct common drawing errors and standardization of functional groups), reionization (ensure the strongest acid groups protonate first in partially ionized molecules), and recalculation of the stereochemistry (ensures preservation of the original stereochemistry). The salts were removed, keeping the largest fragment, which was neutralized, and the remaining partially ionized fragments were reionized. The canonical tautomer was determined, and, from the InChIKey strings of the canonical tautomer, the duplicate compounds were removed.