Helper ligands are a set of ligands known to bind to the receptor of interest with < 1µM affinity, but may not have a solved bound structure. These ligands are used along with the 'docking ligand' in the Open-ComBind pipeline to improve pose selection of both the 'docking ligand' and the 'helper ligands.' We utilize the same two sets of helper ligands as in Paggi et al. : one in which the helper ligands do not share a scaffold with the docking ligand, termed 'Highaffinity helper ligands', and the other in which the ligands have the largest Maximum Common Substructure (MCSS) with the docking ligand, termed 'Congeneric series helper ligands'. We use the MCSS definition from Paggi et al. to ensure we are using the same set of helper ligands.