The tested drugs reveal that the driving force of interactions is through specific forces such as Hbond formation and the sum of the electrostatic and van der Waals energies (Table ). The sum of all these interactions is approximated by a docking score, which represents the potentiality of binding in kCal/mol. The driving forces for these specific interactions in biological systems target complementarities between the shape and electrostatics of the binding location and the ligand or substrate. The effective site of noticeable contribution is with several amino acids of the b6 antennae of the Spike of the S-Sars-Cov2 proteins as indicated in Figures and and Table .