A plug-and-play, continuous-flow chemical synthesis system (Figure ) was intelligently designed by Bédard et al. to mitigate the challenges in organic synthesis by the integration of hardware, software, and analytics. Comprising an array of modular components, including units for heating, cooling, LED light exposure, and packed bed reactors, it provides a flexible platform for various reaction categories. The system consists of a liquid-liquid separator and an inline/online analytical tool to facilitate closed-loop autonomous optimization. The capability of the system was demonstrated in the optimization of C-C and C-N cross-coupling, olefination, reductive amination, photoredox catalysis, nucleophilic aromatic substitution, and a two-step synthesis of cyclobutanone. The molecules synthesized under optimal conditions are presented in Figure , employing the stable noisy optimization by branch and fit (SNOBFIT) algorithm. SNOBFIT offers a convenient methodology for global optimization, eliminating the necessity of a theoretical model. A reconfigurable automated flow platform integrating online HPLC monitoring was used for the cobaltcatalyzed aerobic oxidative dimerization of desmethoxycarpacine to carpanone in the presence of oxygen as an oxidant . A gas-liquid segmented, or tube-in-tube strategy adopted for achieving higher yield in a shorter residence time. Substantial further developments have been made in applying ASFR in multi-objective optimizations which will be discussed under the section 4 in detail.