Table 50% in the organic phase, with a mostly hydrophilic tendency. The rest of the molecules under study are lipophilic chemical compounds to have LogP values greater than zero, which provides positive influence favoring pharmacokinetic properties such as absorption through biological membranes and distribution in the body. TPSA is also a parameter indicative of a drug's ability to penetrate cells. Molecules with a value less than 140 Å tend to cross the biological barriers of the digestive system, mainly the small intestine. Whereas bioactive compounds with TPSA less than 90 Å have the ability to cross blood-brain barrier (BBB) and thus interact with drug targets in the central nervous system . In this sense, NF-31 is the only molecule that violates this parameter, 66 compounds with furan nucleus have TPSA values between 74.57 and 130.92 Å and in turn, 24 of these molecules have values less than 90 Å which would allow their passage through the BBB. According to these data, the compounds under study have a high rate of being bioactive molecules with optimal intestinal absorption. Similarly, at this stage of the study, chronic toxicity parameters were determined, such as: