Given the efficiency of the radical capture and reductive elimination steps, strategies relying on the formation of alkyl radicals have been recently applied to engage alkyl halides in copper catalysis. Thus, Fu and Peters have developed photoinduced approaches to the generation of excited-state Cunucleophile species, which could reduce alkyl halides via SET pathways. The MacMillan group has pioneered the use of silyl radicals, generated via photoredox catalysis, for the activation of alkyl halides in copper catalysis. More recently, Leonori discovered that α-aminoalkyl radicals could enable efficient copper-catalyzed amination of alkyl iodides. Despite these advances, a general activation mode that can allow for the coupling of unactivated alkyl halides with mild organometallic reagents, e.g., alkylzinc reagents, via copper catalysis remains highly desirable.