Out of 21 drugs, the SPs determination by HnV was not possible for 11 drugs (missing black squares in Figure ) e.g. for the drugs Erlotinib, Axitinib and Bortezomib, as the Fdi, Fpi and Ehi values for C-C triple bond, -N= and borane, respectively are not available. For a better comparison of HSPs values obtained by HnV and YMB for the 10 drugs both methods were suitable, the SPs values were replotted and presented in the supporting information (Figure ). As stated previously, no major differences were observed for both group contribution methods. The calculation of molar volume for all the drugs was possible by Fedor's method because of the large number of groups enlisted with their respective values in the literature (Figure ) . The YMB method also has limitations like, it is unable to process the molecules larger than 120 heavy atoms. However, in the case of Cabazitaxel, after inserting the SMILES in the HSPiP software, the HSPs values could not be obtained, although the compound is smaller than the specified limit. The experimental determination of HSPs of drugs was not performed, as the experimental SPs values of the POx and POzi based triblock copolymer have shown the similar results (Figure and Table ).