Over the past decades, an understanding of the lipophilicity of organic molecules has been essential in designing and synthesizing water-soluble drugs. Moreover, once the solvent solubility is determined, a correlation of the pharmacokinetics with the molecular structure needs to be established for the new drug submitted for clinical trials. Besides the development of profiling techniques based on the Lipinski Rule 2 used in drug discovery , determination of the partition coefficient (P), reported as the base 10 logarithm of P (logP, see equation 1), has been a convenient strategy to provide information about a molecule's lipophilicity. The partition coefficient (P) of a substance is defined as the ratio of its concentration in organic and aqueous phases when the system is in equilibrium. logP = 𝑙𝑜𝑔 !" )