Equipped with this knowledge a combined batch-flow reactor was constructed in the same manner as described for BINOL. The overall yield of highly enantioenriched material increased nearly fifty percent to 87%. Boc-protected phenylalanine was added to MRTX1719 as the resolving agent. The ethanol/water (98:2) mixture was stirred at 20 °C overnight to crystallize the desired isomer. The flash epimerization was operated at a temperature of 160 °C, 250 psi, and 2 min tR, and the stream exiting the PFR was fully epimerized as it returned to the crystallization tank. The epimerization results in continual supersaturation of 2a in the batch crystallization unit until all of 2b is converted to 2a and trapped via crystallization. After operation for 14.5 hr, the supernatant reached a nearly 1:1 ratio of epimers, thus removing the driving force for further yield increase. Analogous to the batch operation, residual epimer was rinsed out by slurrying the product in ethanol after the crystallization.