A method was used to screen for the formation of new chiral solvents based on eutectic mixtures and DES. Ten HBAs were combined with > 90 chiral HBDs to screen for the formation of low melting point mixtures. The screening included over 1000 mixtures of variable molar ratios, which resulted in > 300 mixtures as liquids at room temperature. Thirty-two HBA-HBD mixtures formed liquids at all of the molar ratios examined in the study. Successful liquid formation was most common for HBAs and chiral HBDs with the lowest individual component melting points.