An alternative strategy which we proposed would involve design of a suitable substrate class for MHAT catalysis whereby the inherent preference for ortho-cyclisation is supplanted by ipsosubstitution. This type of radical Truce-Smiles rearrangement, has been extensively investigated in recent years, though rarely in combination with transition metal catalysis. An early report from the Stephenson group described a photoredox-catalysed Smiles rearrangement via formation of a carbon-centered radical, formed upon single electron reduction of difluoroalkylbromides. Further exploitation of this concept has allowed a variety of different moieties to be formed. This includes two component domino-reactions, for instance developed by the Nevado group, where electrophilic radicals can react with N-arylsulfonyl acrylamides, leading to the formation of corresponding arylethylamides (Scheme 1c). However, most of these examples rely on olefins that are amide or styrene derived. In contrast, there are fewer examples with simple, unactivated N-allylsulfonamides, which limits the generality of this approach to arylethylamines. Scheme 1. The importance of β-arylethylamine motifs in drug molecules. Hydroarylation via MHAT and radical Truce-Smiles reactions.