Fig. shows the electrostatic effect on the synergistic effect, ∆ el ∆ C F (2) vw⊕el,W ⊕C , along with the corresponding energy and entropy profiles. ∆ el ∆ C F (2) vw⊕el,W ⊕C is attractive at the interface with a value of around -2 k B T at the positions of both the AWI and ACWI free energy minima, indicating that electrostatic effects are a small, but attractive component of the total synergistic effect between DS -and the C 12 E 6 monolayer. From this result, we see that the majority of the synergy seen in Fig. is due to the net-attractive combination of vw stabilization of DS -within the C 12 E 6 monolayer, and the effect of moving the DS -cavity from the bulk water into the monolayer.