We conducted a meta-analysis of the literature of research papers published between January 2017 and March 2023 in peer-reviewed journals with digital object identifier (DOI) numbers, documenting the research of food chemicals interacting with epigenetic targets with potential therapeutic applications or disease prevention. The literature search was done in PubMed 30 and Web of Science Core Collection databases using the following search terms: (("epigenetics" AND "food chemical(s)") OR ("epigenetics" AND "natural products") OR ("epigenetics" AND "therapeutic application") OR ("epigenetics" AND "disease") OR ("epigenetics" AND "drug discovery") OR ("epigenetics" AND "drug development") OR "epigenetic targets" OR "epigenetic therapy" OR "epigenetic mechanisms" OR "epigenetic regulation" OR "epigenetic modifiers" OR "epidrugs" OR "nutritional epigenetics" OR "nutrigenetics"). As part of the analysis, the dietary compounds were determined in the abstract of the selected papers. Then, the most common therapeutic indications associated with these compounds were selected in the related papers.