Therefore, these rapid hydrolyses and loss of N urged scientists to find out a solution to slow down the hydrolysis of urea not only to save the economic loss but also environmental as well as water pollution. Conventionally, different types of urease inhibitors like ammonium thiosulphate, sodium thiosulphate, thiourea, boric acid, hydroquinone, phenyl phosphorodiamidate, and n-butyl thiophosphoric triamide (NBPT) have been manufactured