Recently, it has been found that the catalytic activity can be significantly enhanced by adding organic compounds to the platinum surface. A series of discoveries began with the groups of Sung and Miyabayashi, who found that the addition of amine-terminated organic molecules, such as octylamine, oleylamine, aniline, and hexamethylenediamine, increases the activity of Pt nanoparticle catalysts. Subsequently, Asahi et al. discovered that melamine, which contains more amino groups in a single molecule, further enhances the activity of Pt nanoparticles. Wada and co-workers 46 also found the same effect on the Pt(111) single crystal surface, and recently, Hoshi et al. discovered that adding caffeine to the Pt(111) surface also enhances catalytic activity. Furthermore, Daimon and co-workers found that melamine also improves the durability of the catalyst. The series of discoveries indicates the presence of a new strategy to enhance catalytic activity without sacrificing durability.