The gravimetric calibration experiment was performed by connecting a switching valve, syringe pump, temperature probe, and analytical balance. The switching valve and syringe pump were used to dispense a target volume of water, and the mass of the dispensed water and external temperature were recorded before taring the balance and performing the next measurement. The actual volume was calculated using the density of water at the average recorded temperature of 22.1 °C ± 0.2 °C. Figure shows the relative errors of all recorded volume points. Notably, target volumes above 50 µL had average relative errors below 2.0%, an improvement from our previous peristaltic pump-based solution handling platform which had 2.0% relative error at target volumes of 100 µL. The acid-base titration experiment was performed by connecting a switching valve, syringe pump, temperature probe, and pH meter. The pH meter was calibrated automatically using standard pH 4.00, 7.00, and 10.00 buffers. 4 mL of 0.1 M H3PO4 was dispensed, followed by 100 aliquots of 100 µL of 1 M NaOH as a titrant. The solution pH was measured after each dispensing operation, and the titration experiment was repeated 4 times in total. Figure shows the resulting titration curve. The pKa values for the first two deprotonations were measured to be 2.227 ± 0.007 and 6.91 ± 0.03. The measured pKa values differ slightly from the reported values of 2.16 and 7.21, but differences in temperature over the course of the experiment may explain the deviations from reported values (Fig ). This experiment showcases our platform's capability for titration experiments, highlighting its versatility beyond automated electrochemical experiments previously demonstrated.