"Easy" Proteins (Max Path 0-2) In the ribosome, 5 proteins (L30 and L32-36) can potentially be made as a single segment up to 60 aa, 3 proteins (S21, L27, and L31) can be accessed through a single NCL at an ideal site (i.e., good thioester with Cys), and 6 proteins (L19, L22, L33, L12, S15, and S20) require a single NCL followed by desulfurization at an Ala site. These proteins have few possible division points, and the best choice (prioritizing assembly of soluble, medium-length segments ~40 aa) is often obvious without computational assistance. Unexpected problems encountered during synthesis -segment insolubility, impurities from SPPS, or especially poor ligation efficiencycan often be overcome by brute force (i.e., starting with more material and accepting low yield) or by introducing additional side-chain modifications such as temporary solubilizing tags or chemical auxiliaries for templated (proximity-aided) ligation. We therefore define this category as "Easy", as these proteins should be generally accessible with standard CPS techniques.