Moreover, the inhibitory effects of hemin and H-Tyros at the concentration of 8 μM were lower than those of the lower concentration, 4 μM. Importantly, while C-PTIO showed a • NO-scavenging efficiency, its effects on the • NO-induced cell migration were nearly absent. In this case the rate of cell migration was similar to that of DETA-NO only-treated cells. To compare these results with the effects of the tested compounds only, they were diluted in the FBScontaining medium in the lower chamber without a • NO-donor, and cell migration was evaluated. As shown in Supplementary fig. , slight changes in cell migration were observed, with a significant inhibition in the case of 4 μM hemin. However, H-Tyros enhanced the migration at both tested concentrations, relating to certain chemical changes. This applies when it is added to the chemoattractant medium, in contrast to what was observed in the presence of • NO. Similarly, 4 μM H-Styr in medium significantly enhanced the migration, while the higher concentration did not affect it.