In our analysis of the refined data, we found that solubility is enhanced under two conditions: (i) disruption of the central symmetry in core structures, exemplified by the substitution of an N/O atom with a carbon atom within the benzene ring, which increases polarity; and (ii) the incorporation of functional groups such as -OH, -COOH, -NH 2 , and -SO 3 H, which enhances hydrogen bonding and solute-solvent interactions. These concepts have been extensively discussed in chemistry textbooks.