The VSM is a hedgehog signalling inhibitor used for the treatment of basal cell carcinoma . Like DSA, VOR, GEN and BTZ, upon Ra calculation, the hydrophilic pMeOx showed higher compatibility for VSM in comparison to hydrophobic blocks while for hydrophobic blocks, the estimated compatibility was in the order of pBuOx ≈ pPrOzi > pPentOx > pBuOzi (Figure ). Experimentally, VSM was essentially insoluble in plain water (Table ) but with the A-pPentOx-A triblock copolymer, we were capable to solubilize around 8.8 g/L (at 10 g/L VSM feed) (LC ≈ 47 wt.% and LE ≈ 88%) (Figure ). The A-pBuOx-A and A-pBuOzi-A also exhibited very high solubilizing capacity of 7.2 and 7.5 g/L, respectively, albeit less than A-pPentOx-A. Utilizing the A-pBuOx-A triblock, very recently, Hwang et al. also reported the VSM formulation capable to solubilize around 7.5 g/L VSM (at 8 g/L feed) ,