Chitosan is widely regarded for its strong mucoadhesive nature, as it typically allows for the NPs to attach to linings with mucus throughout the body, further increasing the time. However, this is not without challenges, as according to M. Ways et al. chitosan's derivatives have limited water solubility at neutral and basic pH levels. Therefore, there will not be an issue for nanoparticles that are delivering drugs in acidic environments, such as the stomach, but for organs like the intestines, this will create difficulties in drug delivery.