The extended metal node structure of MIL-100 MOFs likely contributed to their effective anchoring capacity in contrast to MIL-53 MOFs. It seems that MOF structural features are important for GUV anchoring and its extended immobility. For the MIL-100(Al), the dispersion of MOF particles in the solution appeared to compromise GUV integrity. Aggregates of smaller vesicles were observed, many of which failed to fully separate (Figure ). GUVs did remain immobilized by the MOF particles when observed at the 2 hour (Figure ) and 6 hour time mark (Fig. ) and less over 12 hours (Figure ); however, unbound mobile GUVs exhibited significant changes in membrane curvature, losing their spherical shape within the 12 hour mark (Figure , S12e). Conversely, MIL-100(Fe) particles provided efficient anchoring for GUVs, with consistent immobilization observed at the 2 hour (Figure ), 6 hour (Figure ), and 12 hour (Figure ) intervals. Nevertheless, some vesicles began to exhibit signs of membrane instability by losing their spherical shape, suggesting that prolonged anchoring may induce stress on the vesicle membranes.