Compared to other quantitative SAR analysis methods such as Free Wilson analysis, the EVP methodology does not require any predefined scaffold to be applied. Additionally, our methodology is focused on the pattern-level information embedded in EVPs rather than on the differentiation of individual substituents. Another application in the context of SAR analysis can be imagined through integrating an EVP analysis with protein-ligand structural information. If crystallographic structures of hit compounds bound to their target protein are available, this information could be used to focus on only particular EVPs being taken forward for further optimization (due to steric hindrance or favorable directing interactions towards protein residues, etc). In this scenario, the decomposition of the EVPs can identify the explored and underexplored vectors of interest, as well as quickly remove any unwanted EVPs from an initial selection.