Robust alterations in expression pathways with advancing age have been reported, with a great part of these pathways controlling messenger RNA splicing. Furthermore, interventions that reverse senescent phenotypes help in restoring youthful patterns of splicing factor expression. It is believed that alterations in RNA processing add an additional level of gene expression regulation over those of genome integrity, transcriptional efficiency and epigenetic regulation that have been already recognized to change during aging. Thus, dysregulation of RNA management regulation in aging human population has been identified as a characteristic aging feature.