The CAS Content Collection is the largest human-compiled collection of published scientific information. It represents a valuable resource to access and keep up to date on the scientific literature all over the world, across disciplines, including chemistry, biomedical sciences, engineering, materials science, agricultural science, and many more. This allows quantitative analysis of global research publications across various parameters including time, geography, scientific area, medical application, disease, and chemical composition. Currently, there are over 50,000 scientific publications (mainly journal articles and patents) in the CAS Content Collection related to polyQ diseases, including Huntington's disease, spinocerebellar ataxias, SBMA and DRPLA. There has been a steady growth of these documents over the last three decades, with an >25% increase in the last three years (Figure ). Noteworthy, while in the earlier years, scientific journal publications notably dominated (journal/patent ratio >4-5), after around the year 2002 the number of patents exhibited significant growth (journal/patent ratio ~2) (Figures ), correlating with the initial accumulation of scientific knowledge and its subsequent transfer into patentable applications.