We can consider each MD trajectory as a single measurement of the system with the resulting constants ⟨A⟩ = ⟨B a ⟩, ⟨B⟩ = ⟨B b ⟩, ⟨C⟩ = ⟨B c ⟩ obtained by either one of the MRC/MIITU/MIITO procedures. The actual result, however, requires averaging over several of such MD trajectories started from different initial conditions. Therefore, the final values are the results of double averaging from multiple trajectories, defined as