This research showcased the efficient defluorination of PFOS and Nafion using visible LED light irradiation onto semiconductor NCs at room temperature under atmospheric pressure. Because CdS is a typical compound semiconductor and nonlinear reactions are prevalent across various compositions, this demonstrated concept has the potential for broader applicability to other low-toxicity materials. The proposed methodology is promising for the effective decomposition of diverse perfluoroalkyl substances under gentle conditions, thereby significantly contributing towards the establishment of a sustainable fluorine-recycling society.