We have previously reported the non-normal properties of calculated binding free energies. In the current study, we investigate the distributions of experimentally measured free energies, and find that the distributions are highly skewed. The practical implications of this discovery are important to apprehend. Non-normal distributions imply the occurrence of more 'outliers', making it essential to perform multiple measurements to pin down average behaviour. It is also a call to exercise caution in the use of statistical methods for the comparison of experimental data and computational predictions, as the assumption of normal distributions is not generally valid. (grant no. 800957), and NSF Award (, Award No. NSF 1713749). We made use of the Blue Waters supercomputer at the National Center for Supercomputing Applications of the University of Illinois at Urbana-Champaign, access to which was made available through the aforementioned NSF award. Additional calculations were conducted using an award of computer time on the Theta machine at Argonne