The replicase of COVID-19 made 465 pocket similarity above 0.6, and a total of 135 drugs, it should be noted that all antiviral drugs predicted by PocketMatch were able to bind to the predicted binding site with the top docking pose table , except Acyclovir. The docking was made on all of the complex chains (Nsp15, Nsp12, Nsp8, Nsp7, Nsp3), but only the drugs could only bind with high affinity to Nsp12 and Nsp3.