The most important feature of a flexible ligand docking methodology is its ability to produce a ligand pose within 2.0 Å of the crystallized pose of the ligand. Since our methodology has inherent ligand flexibility due to its hierarchal nature, we evaluate its ability to produce ligand poses both near and far from the native crystal pose of the ligand regardless of the score of the ligand pose. At this stage we wish to investigate if a single "good" pose is present among the docked poses. The plots of RMSD values generated indicate that our algorithm adequately samples the conformational space of the ligands in the PDBbind Core set (Figure ). Their Boltzmann-like distribution indicates that conformations both far from, and close to the ligand pose are sampled.