Biochemical alterations in diseases, along with their treatments, can significantly impact tissue biomechanics. In rheumatoid arthritis, chronic inflammation and elevated levels of proteolytic enzymes degrade cartilage, altering its mechanical properties. Treatments aimed at reducing inflammation can alleviate these biomechanical disruptions, highlighting the importance of integrated therapeutic strategies . Also, during allergic reactions, an overactive immune response leads to inflammation, tissue swelling, and increased vascular permeability, disrupting normal tissue function. Effective treatments must address both biochemical disruptions and mechanical integrity restoration .