Previously, the similar phenomenon was also reported for POx/POzi micelles with moderately hydrophobic block, such as in the CUR-loaded A-pBuOx-A formulation (CUR feed ≥5 g/L) and CUR-loaded Generally, the chirality of copolymers does not appear to affect the long-term stability of IBU loaded formulation, with the notable exception of few A-p RS EtEtOx-A and A-p RS PrMeOx-A formulations (vide infra). Exemplarily, the long-term stability of M A-pEtEtOx-A/RS-IBU and M A-pPrMeOx-A/RS-IBU formulations are used to discuss the general behaviour of A-pEtEtOx-A and A-pPrMeOx-A series formulation, respectively (Fig. ). Up to 6 g/L RS-IBU feed, the LC of M A-pEtEtOx-A/RS-IBU decreased slowly in 30 days. In contrast, at 8 and 10 g/L RS-IBU feed, the LC dropped significantly around day 20 (Fig. As mentioned in drug loading part, A-p RS EtEtOx-A and A-p RS PrMeOx-A have the maximum LC of R-and RS-IBU at a drug feed of 8 g/L. Accordingly, the long-term stability of RS-IBU loaded A-p RS EtEtOx-A and Ap RS PrMeOx-A formulations are shown for these special cases (Fig. and). Similar to M A-pEtEtOx-A/RS-IBU, up to 6 g/L RS-IBU feed, the LC of A-p RS EtEtOx-A/RS-IBU decreased gradually over 30 days period.