We report here the synthesis of macromonomers containing ester-urethane linkage using three different non-organotin catalysts (BiNDE, BiHex, and ZnAc). FT-IR and NMR studies indicated that all of the tested catalysts resulted in the same structures for the ester-urethane macromonomers. Further, after photocuring, the elastomeric networks obtained from macromonomers synthesized with zinc and bismuth catalysts had suitable mechanical properties for soft tissue regenerative medicine and lower cytotoxicity, as compared to DBTDL-regardless of photocuring atmosphere. Collectively, our results indicate that it is possible to reduce the overall health and environmental safety impact of this macromonomer synthesis reaction by using less toxic catalysts and "green" solvent (ethyl acetate). This is very beneficial not only from the point of view of potential biomedical applications, but also from the safety of the process and overall life cycle of the materials. After considering of all measured parameters as well as the reaction times, we conclude that 2 mol% of BiHex catalysts may offer the best compromise between reaction time, mechanical properties, and cell viability.