Averaging over the rigorous multiple distance restraint schemes (M-Rig, M-All-R, and M-Hand-R), the mean ∆G o Bound result for pose A was -6.16±1.43 kcal mol -1 . This was in good agreement with the mean result for pose A calculated with Boresch restraints (-6.28 ± 0.49 kcal mol -1 , average of B2, B3, B1-P, and B3-P, and B2-10). Ignoring the contribution to the free energy of binding from pose B, for which no calculations were performed with multiple distance restraints, the free energies of binding would have been -9.24 ± 1.44 kcal mol -1 and -9.36 ± 0.37 kcal mol -1 for multiple distance restraints and Boresch restraints, respectively.