IBU is a non-steroidal anti-inflammatory drug (NSAID), possesses a single stereogenic carbon atom which gives rise to two enantiomers, S-and R-IBU. This drug is commercially available racemate, even though S-IBU is more potent than R-IBU as inhibitor of cyclo-oxygenase I. In addition, there are a few reports on IBU loaded POx-based hydrogels. IBU is commercially available as its chiral and racemic forms and due to its low aqueous solubility, we chose it as a model drug to study solubilization in our novel chiral and achiral POx. The series of A-pEtEtOx-A, A-pPrMeOx-A triblock copolymers were used to solubilize R-IBU, S-IBU and RS-IBU.