There is ongoing research aimed at developing disease-modifying therapies for polyQ diseases. Approaches include gene silencing techniques like RNA interference (RNAi) or antisense oligonucleotides (ASOs), small molecule inhibitors targeting toxic protein aggregation, and strategies to enhance protein degradation pathways. Advancements in genetic testing and understanding of disease mechanisms have paved the way for personalized treatment approaches tailored to individual patients' genetic profiles and disease progression. Research is focusing on identifying compounds and interventions that can protect neurons from the toxic effects of mutant polyQ proteins, potentially slowing disease progression.