We explored the role of reaction kinetics on BO performance by substituting ethanol with isopropanol, a secondary alcohol with slower reaction rates. The normalized CVs for BO and random sampling are shown in Figure and, respectively. The CVs for the isopropanol experiments exhibit similar behavior as observed for ethanol, however BO campaigns with isopropanol more gradually adjusted towards the optimal sigmoidal shape, likely due to the slower kinetics of this system. When we look at the average hysteresis value at each iteration for isopropanol (Figure ), we see that BO clearly outperforms random sampling. When comparing BO performance for both alcohols, we see that it takes ~10 iterations for the isopropanol trials to begin converging, as opposed to ~5 for ethanol. We attribute this to the accessible parameter space of isopropanol having less overlap with the KS zone than ethanol, decreasing the likelihood of quickly locating a region that yields minimized hysteresis. This is evident in the random sampling experiments for isopropanol, which failed to identify CVs suitable for kinetic analysis compared to the ethanol experiments. Instead, the isopropanol random sampling experiments predominantly yield CVs in the D zone (Figure ).