The sample size was determined by the area of chemical interest. A specific conversion (limonene to paracetamol) was to be investigated thus every molecule that could be reached within one reaction from any molecule on any path not longer than four steps connecting the two molecules was included to form the network. The basis here was the corpus of reactions obtained from Reaxys® under the R&D Collaboration Agreement with Elsevier. Reaxys aims to abstract the corpus of organic chemistry journals. It was decided to exclude any reaction which was incomplete, i.e. did not have any reactants or any products listed in Reaxys. Other than that no data was excluded. Heuristics were developed for which results to look at in detail, however, all results were used to calculate likelihood ratios. All statistical tests were completed a total of four times. The actual reaction prediction was not repeated. The tested hypothesis was that the SBMbased approach would be able to outperform other graph theoretical metrics and could be applied to reaction prediction. No prior assumption had been made about the most suitable SBM configuration. The SBMs were used as implemented in graph-tool.