Recently, DNA nanotechnology has demonstrated the formation of liquid-like DNA coacervates (DNA droplets), which have attracted interest as design-based methods for forming and controlling biopolymer coacervates. DNA nanotechnology relies on the programmability of DNA sequences based on the computational prediction of the thermodynamic stability of base pairing and the physical topology of DNA strings and has achieved DNA nanostructures , DNA hydrogels , and assemblies of DNA nanostructures on lipid membranes or oil-water interfaces . The established knowledge of DNA nanotechnology has been applied to the design and formation of DNA droplets constructed with branched DNA nanostructures (called DNA motifs or DNA nanostars) , and multi-block long single-stranded DNA (ssDNA) generated by rolling-circle amplification . These studies also demonstrated the dynamic behavior of DNA droplets , such as phase separation and the division of two immiscible DNA droplets with orthogonal sequences , bubbling of DNA droplets with an enzymatic reaction , disruption of lipid membranes , DNA logic computation , and droplet locomotion .