In an attempt to determine which multiproduct reactions contained the highest degree substances we plotted in, out and total degree distributions for substances of multiproduct reactions as seen in Figure S??. The out degree can be as high as 10 5 (!!). To narrow down the most common high degree substances, we further filtered the top 20 highest degree substances (degree distributions shown in The total height of each bar refers to the total number of routes returned. The percentage on the bar represents the ratio with respect to the total routes for each category. Red indicates routes not found due to a cycle detected in route candidate or the target molecule being the only node in the synthesis graph. The lightest green are routes that were also found in the same database configuration at a previous reaction step, while the medium shade of green represents routes that are partially identical to routes at previous reaction steps. Finally, the dark green are unique routes found. In cases where the number of routes not found is so small the bar is not visible, the percentage is labeled on top of the other bars.