The AdSoS scheme can be easily extended to small rigid solvents other than water. For each molecule, one has to choose a reference atom for the scaling, ideally a central atom. Further generalization to larger and/or flexible solvent molecules may be possible using a group-based approach, whereby different atom-groups in the solvent molecule would be associated to their own scaling factors. However, in this case, the linear scaling of the interatomic distances with preservation of the angular structure would only be guaranteed within (and not between) the fragments, and the selected groups should be kept neutral so as to prevent the creation of a solvent net charge upon scaling. In the future, the solvent-scaling will also be used not only to accelerate solute-insolvent simulations for aqueous solutes, but also to accommodate different solvents and/or solvent mixtures.