Therefore, starting from the ideas of additivity of drug synergy, and the knowledge how genes are related via their biological processes, the aim of this research paper is to propose and select drug combinations that are connected biologically, either by process type or by common branch connectivity. This could facilitate the identification of potential drug combinations to investigate for synergy without already having measured information about the drugs' potential synergy previously. The approach being examined is that drug combinations can be identified with network connectivity and extend an already established mathematical model, the Loewe-Additivity mathematical model. The principle of Loewe-Additivity model is that two drugs that work on the same drug target can be calculated whether the combination is additive, antagonistic, or synergistic . The standard Loewe-Additivity model has limitations in that two drugs must share a common target (see Figure ).