In this case the RMSE was under 2 kcal/mol for both methods, but CGENFF resulted in very slightly better performance by most metrics. Problematic systems for this method were MGLab23-g1, MGLab24-g1, MGLab24-g2, MGLab36-g1, and MGLab36-g2, and what they have in common is larger cyclodextrin side chains. Cyclodextrins with amino acid side chains tend to be the more accurately predicted systems for this method, suggesting the methods may be limited by forcefield parameters.