In quantitative terms, the S CH response seen in Fig. for POPC is smaller than for DMPC: The median magnitude change from full to lowest hydration is 0.06 over the POPC and 0.08 over the DMPC carbons. The largest quantitative difference between lipid responses manifests in the second-last and third-last saturatedtail carbons, whose mean S CH changes roughly 70% more in DMPC than in POPC. In both DMPC and POPC saturated tails, the most pronounced dehydration response occurs midchain.