To a suspension of 25 (2.30 g, 5.01 mmol) in ethanol (75 mL) was added 1M aqueous sodium dithionite solution (75 mL) and the reaction was heated to 80 °C for 1 h. Upon cooling, the reaction mixture was partitioned between 10% ammonium hydroxide solution (75 mL) and ethyl acetate (75 mL). The organic phase was separated, and the aqueous component was extracted with ethyl acetate (3 × 25 mL). The combined organic extracts were washed with brine (100 mL), dried over anhydrous magnesium sulfate, and concentrated under reduced pressure to give the title compound as a yellow oil, which was used directly in the next step without any further purification (1.36 g, 70% Purification by flash column chromatography, eluting with 3-5% methanol (with up to 0.5% NH4OH) in dichloromethane, produced a pale brown gum (2.59 g, 3.908 mmol). The residue was then dissolved in acetic acid (50 mL) and heated to reflux for 1.5 hours, concentrated under reduced pressure and reconcentrated from heptane (5 × 75 mL). The brown gum was dissolved in anhydrous ethyl acetate (60 mL) and purged with nitrogen (g). To this stirring solution was added hydrogen chloride (6 mL, 11.72 mmol, 2M solution in diethyl ether) and a solid immediately formed. Excess diethyl ether was added, and the solution was left to stir overnight at ambient temperature. The precipitate was then collected by filtration, dried under vacuum and freeze dried, affording the title compound as an off-white solid (3.04 g, 36% before leaving the reaction to stir at ambient temperature overnight. The mixture was then partitioned between dichloromethane (25 mL) and water (25 mL). The organic phase was separated and washed with saturated aqueous sodium hydrogen carbonate solution (25 mL), brine (3 × 10 mL), dried over anhydrous magnesium sulfate and concentrated under reduced pressure. Purification by flash column chromatography, eluting with 0 -10% (7N ammonia in methanol) in dichloromethane, afforded the free base as a colorless oil. This was dissolved in anhydrous ethyl acetate (10 mL) and purged with nitrogen (g). To this stirring solution was added hydrogen chloride (0.17 mL, 0.33 mmol, 2M solution in diethyl ether), whereupon a solid immediately formed. Excess diethyl ether was added, and the mixture was left to stir overnight at ambient temperature. The precipitate was collected by filtration to afford the title compound as a colorless solid (120 mg, 77%