In the 60+ years since the introduction of Cahn-Ingold-Prelog Sequence Rules in 1956, the "CIP Rules" have become an integral part of chemical nomenclature, providing a way to identify the spatial arrangement of atoms of a molecule using simple mostly atom-or bond-based stereodescriptors. Over the course of this time, various authors have pointed out deficiencies in the rules and proposed solutions in the form of modifications and subrules, to the point where today we have eight distinct Sequence Rules: 1a, 1b, 2, 3, 4a, 4b, 4c, and 5.