In general, Prompt B and C generations were obtained without difficulties, except for rate limit issues experienced for o1preview. Several other models not listed in the report were tested, but could not be used because of context window limitations in processing larger inputs. Paper 10 featured text partially written in Chinese, and was not able to be processed by o1-preview, but was processed by ChatGPT-4o, which incorporated biochemical terms outside of the English abstract into it's generation. This study comes after Liu, H., et al.'s 2024 paper on "Integrating chemistry knowledge in large language models via prompt engineering", which featured Paclitaxel reaction guidance using ChatGPT-3.5 turbo .