With both the reactivity and stereoselectivity issue being solved for these key substrates, the basic reaction generality of these second-generation conditions to access densely functionalized carbon frameworks was evaluated (Figure ). dDCC between two α-heteroatom substituted acids RAE, affording 37 in 52% isolated yield (>20:1 dr). Subsequent union of this fragment with another equivalent of 6-RAE after hydrolysis/RAE formation under cis-selective dDCC conditions furnished protected polyol ester 38 in 30% isolated yield (>20:1 dr). The third and final C-C bond forming event was accomplished again using another decarboxylative coupling method: