Biomembranes should be more extensively investigated as an intelligent biomimetic system to provide important stimuli to cells as well as enhance specific intercellular interactions within the OCC system. Finally, a key technological issue needs to be faced. The large-scale fabrication of microfluidic devices is challenging, and the integration of membranes is still laborious and time-consuming. Therefore, novel processing techniques of membranes in microfluidics are crucial for membrane-based microfluidics to reach its full potential.