Alginate and hyaluronic acid can provide extracellular matrix-like environments for cellular movements due to their mechanical and biological properties that make them biocompatible to form alternative cartilage, vascular structures, skin, and muscle. Chitosan is mainly used for cartilage, bones, and skin. Cellulose has been utilized with different types and derivatives such as nanocelluloses to form cartilage tissue. Cellulose usually combines with other known hydrogels and is printed as biomedical devices. Top Inorganic Substances Hydroxylapatite (HAp, Ca5(PO4)3(OH)), is heavily used as the filler in dental material and bone repair. Tricalcium phosphate is also anther filler for bone regeneration/repairs in combination with other biopolymers. Graphene oxide and graphene are both used in bone regeneration/repair as the additive to reinforce the polymers. Graphene filament combined with PLC is printed as the 3D electrode to become the biosensor. Zirconium dioxide (ZrO2) is used as a filler combined with other polymers in dental prosthesis or bone implant materials. Alumina, silica, and silicon are usually utilized as the dental crown model, artificial teeth, and denture base materials. Carbon nanostructures are utilized to form 3D printing implants for bone tissue remodeling , and carbon fibers can form microlattice 3D hybrid scaffold for tissue engineering. Titanium/Ti6Al4V are involved in bone tissue remodeling, bone defect repair, knee implant, etc. Gold nanotubes or nanowires can be combined with decellularized extracellular matrix to form hydrogel for tissue engineering or directly used for medical implant 39 .