The implications of deployment location on costs and life cycle GHG emissions were characterized via a contextual analysis considering country-specific factors (including average wages, grid electricity price and makeup, and bodily waste characteristics) for China, India, Senegal, South Africa, and Uganda. The results from this study provide insight into opportunities to advance the sustainability of the NEWgenerator and, more broadly, NSS through targeted research, development, and deployment of treatment and resource recovery technologies.