Global docking-also known as blind docking-involves the thorough study of the whole surface of the protein to identify likely binding sites and project the ligand binding mechanisms without first understanding the exact location of the binding site ( ) (Figure ). Unlike local docking, global docking does not necessitate prior knowledge of specific binding cavities, enabling an impartial evaluation of the binding affinity between the target and ligand ( ). Global docking comprehensive technique facilitates the identification of previously unnoticed binding sites that more targeted methods may disregard. Hence, global docking is especially advantageous during the initial phases of drug development since it facilitates the creation of novel pharmaceuticals by offering a comprehensive perspective of potential interaction sites throughout the complete target protein. Global docking can potentially uncover previously undiscovered binding sites, which can then be used to create more potent and groundbreaking medicinal medicines. The most cited global docking programs are ZDOCK ( ), FlexX ( ), GOLD ( ) and MEGA DOCK 4.0 ( ).