We calculated two different fingerprints: MACCS keys (166-bits) and Morgan radius 2 with RDKit node for KNIME. Preliminary results showed that the similarity inter and intraset is lower than the calculated with molecular properties. Cumulative distribution functions computed with PUMA showed median similarity values from 0.471 to 0.590 with MACCS keys and 0.114 -0.149 with Extended Connectivity Fingerprints radius 4, both results present interset similarity. Overall, the results showed that new molecules exhibit highly similar properties. These molecular properties were established as secondary constraints by the scoring function.