The first open software application that implemented a scaffold tree was Scaffold Hunter . Starting as a tool mainly for generating and visualising scaffold trees, it has evolved into a multi-functional cheminformatics platform for visual data analysis. By default, the prioritisation rules are applied as published by Schuffenhauer et al. , but they can be customised by the user or even turned off completely. Varin et al. used the latter option to generate their scaffold networks using Scaffold Hunter . The rich-client application is implemented in Java and employs the Chemistry Development Kit (CDK) for cheminformatics tasks.