In this article we first provide an overview of the operation of the PSI, highlighting its most recent workshops. We then describe the controlled vocabularies, guidelines, and data formats that have been developed and ratified by the PSI over the years. Next, we describe the set of standards that are currently in various phases of development, with an open call for participation by anyone willing to contribute to our efforts. Finally, we provide a brief discussion of synergies with other related organizations in the life sciences community and conclude with a vision of future contributions to the field.