This allows BLUES to reproduce the correct equilibrium populations (Figure (C), right), and on a force evaluation basis, NCMC was approximately 17 times more efficient than brute force MD with Markov State Modeling. This is also evidenced by the fact that over the same number of iterations, BLUES converges rapidly to the correct equilibrium populations within 2000 iterations (Figure ), whereas MD and MD/MC still have significant errors. For MD after 5000 iterations the major binding mode populations differ from the equilibrium populations by as much as 45%; for MC they differs by as much as 26%.