Further understanding can be driven by the experimental community by measuring reaction rates in strategically chosen sets of solvents; for example, solvents of different polarity that do not have the ability to hydrogen bond, or non-polar solvents that vary in molecular size and shape. These sets of solvents can potentially isolate different effects which cannot be explicitly seen computationally using polarizable continuum models. Computational efforts can be directed towards re-optimization of reactant and transition state geometries in solution in order to confirm that single-point energy calculations on gas phase geometries are enough. While increasing the level of theory of QM calculations is helpful, subtracting transition state and reactant energies in both phases will cancel some error introduced by the imperfect electronic structure calculations. Strategic collaboration between experimentalists and theorists are crucial to confirm and strengthen these conclusions about solvent effects.