Dynamic self-assembly (DySA) theory and practice have improved significantly since the term was marked to a worldwide audience. Many articles were presented on the constructions of stimuli-responsive, out-of-equilibrium, or energy-dissipative systemsadaptive systems from that time. Nonetheless, the interfacial, two-dimensional responsive systems remain relatively unexplored. Reducing the system's dimensionality to quazi-2D provides new possibilities and applications. It allows for better control over interactions between building blocks. We envision such systems becoming fundamental for creating abiotic compartmentalized chemical networks. However, additional factors like large gradients of properties, nanoparticles` conformation, ligand interdigitation, surface excess of ions close to the interface, or immersion level introduce complexity to the analysis.