Molecule structures were further investigated by the cosine similarity in frequencies of Bemis-Murcko-Scaffolds (contracted molecule structures containing only ringsystems and linkers) and BRICS-fragments (breaking of retrosynthetically interesting chemical substructures). Throughout all filter steps the cut-and-join operator gives very low Scaffold similarity of 1% to 7%, which reflects the ability to generate vastly different ring systems. The cut-and-join crossover operator also preserves the distribution of ring topologies even when using small sub-samples of molecules, as shown in Fig. . The recombination products also keep a balance of its BRICS fragments with similarities to the USPTO10k spanning from 41% to 70%.