BRENDA 2023-1 was downloaded from the internet (free of charge). Scripts to load BRENDA entries were taken from Ref. 49, and several formatting fixes, such as missing whitespaces or hyphens were added. Raw BRENDA reactions are given as text strings, with substrates and products specified by trivial names, as well as a tag to indicate reversibility. An example entry is shown in Fig. , where after step 1 (extracting names and stoichiometry), the reaction text of the reservible reaction acetylene + H2O = acetaldehyde {r} was obtained, where one molecule of acetyle and water react to one molecule of acetaldehyde. When querying BRENDA, we find that this reaction is linked to acetylene hydratases in 12 different organisms (where for nine of them reversibility is indicated), 14 literature references and one uniprot entry.