Our work demonstrates a new strategy for achieving solubility and processability of conjugated polymers by incorporating conjugated macrocycles directly into the polymer backbone, eliminating the need to attach side chains. This approach is exemplified by the synthesis of two novel macrocycle-containing conjugated polymers, poly(PCT-T) and poly(PCT-2T), which were found to be soluble in chloroform despite lacking any side chains. ESD-STM analysis of poly(PCT-T) revealed an ultralow number of structural defects, a high degree of conformational flexibility, and a preference for linear conformations, indicating that the high solubility is not due to a highly kinked or irregular polymer structure that would impede intermolecular packing and aggregation. The STM analysis further indicated a random distribution of cisand trans-PCT isomers along the polymer backbone and a preference for the incorporation of trans-PCT isomers. Interestingly, a small percentage of polymer chains were observed to close over themselves, suggesting the formation of cycles composed of up to 15 repeat units. Both powders and spin-coated thin films of poly(PCT-T) and poly(PCT-2T)