Since the finding of patient zero in Wuhan, China, a wide spectrum of clinical manifestations has been discovered as we have understood the COVID-19 disease. The most common initial symptoms are cough, fever, anorexia, and dyspnea . The most common clinical features in severe COVID-19 patients are dyspnea, severe hypoxemia, lung edema, respiratory failure, ARDS, lymphopenia , cardiac arrhythmias, rhabdomyolysis, hyperferritinemia, intravascular coagulopathy , and pulmonary thromboembolism . Also, it has been observed that 15% of patients required supplemental oxygen and 5% of patients required mechanical ventilation. In addition, the smaller percentage of patients who required mechanical ventilation suffered comorbidities that lead to sepsis and septic shock . Nowadays, it is known that SARS-CoV-2 is capable of reaching other organs depending on the host . Different studies worldwide refer that clinical presentation vary between individuals, presenting manifestations not only respiratory tract infection, but also blood, skin, kidney, liver, ocular symptoms, neurologic signs, among others . Therefore, it is necessary to continuously review the reports on clinical manifestations in order to get to know the behavior of this disease as well as to think over the physiopathological mechanisms that allows us to better understand the related complications.