However, temperature ranges for both the main product and impurities can be ascertained, and therefore could indicate potential design spaces for optimization to minimise impurity formation. antidepressants. There are several steps to its synthesis, see Scheme 2, where the first contains significant impurities as reported by Liu et al. The synthesis involves hydrogenation of (7-methoxy-1-naphthyl)acetonitrile forming an amine main product (intermediate) .