Importantly, the absolute energy required for the isomerization reaction to occur, referenced by the system with no MB-SMD, decreases with the application of the many-body potential, see Fig. . This indicates that the many-bodied deformation not only includes additional strain energy into the system, but also lowers the energy threshold needed. The decrease in activation barrier can be separated into the decrease in absolute energy threshold and the initial energy state increase due to deformation. Roughly two thirds of the activation barrier decrease from lowering the absolute energy needed, and one third of the decrease is from the torsional strain energy added to the system. Thus, many-body strains can not only reduce the energy required to activate mechanochemistry, but also drive it through a new lower energy path. Lastly, torsional deformations resulting in dihedral angles approaching 20 (change in >50) result in a small percentage of systems undergoing isomerization without applying a linear strain, at 300 K.