The control of small structures in living cells is among the most attractive methodologies in life science and nanotechnology . For example, recent progress in cellular biology reveals that the small droplet structures that are formed by liquid-liquid phase separation (LLPS) determine cell behaviors . The dynamic LLPS of biomacromolecules generates temporal compartmentalized space , as well as accumulated substrates and enzymes in the droplet, to ensure the effectiveness of the tandem reaction process and/or increase the enzyme activity . LLPS droplets are greatly observed in transcription, as well as in the stress responses of mammals and plants . Droplet formation is also related to the pathological role of proteins related to neurodegenerative diseases, such as Alzheimer's disease . Thus, the manipulation of the formation/deformation of liquid-liquid phase-separated (LLPS) droplets would be profitable for next-generation targeting in cell engineering.