Performance in the SAMPL7 log P challenge was poorer than in the SAMPL6 log P challenge. In the SAMPL6 log P challenge, 10 methods achieved a RMSE ≤ 0.5 log P units, while here, none did. In general, the SAMPL7 molecules were more flexible, which may have contributed to this accuracy difference. The chemical diversity in the SAMPL6 challenge dataset was limited to 6 molecules with 4-amino quinazoline groups and 2 molecules with a benzimidazole group. The SAMPL7 set was larger and more diverse, thus possibly more challenging.