A common misconception in this context is that strong coupling affects only signals of spin particles for which the shift difference is not much larger than their mutual coupling. Such a situation can indeed also affect other neighboring spin particles that have a large chemical shift difference to the two close ones. This is for example seen as a distortion in the expected doublet of the alpha proton in sugars when their β and γ hydrogens are very close. Therefore, it is important to realize that the HNMR spectra of the vast majority of organic molecules have significant elements of higher-order spin systems. In fact, it is rather challenging to identify chemicals that do not contain such elements and give rise to pure first-order HNMR spectra .