RMSEs ranged from 0.6 to 4 log P units-15 methods achieved a RMSE of 1.0 or lower, while a RMSE between 1 and 4 log units was observed for the majority of methods. Many methods achieved an accuracy similar to the null model which had a RMSE of 1.2 and predicted that each compound had a constant log P value of 2.66. A few methods outperformed the null model (4 were empirical and 1 was an QM based method). In general, empirical methods tended to perform better than other methods, which makes sense given the availability of octanol-water log P training data.