This review aims to provide a comprehensive overview of the current state of knowledge regarding the application of metabolomics in studying plant-microbe interactions. We will discuss the various metabolomics techniques employed in this field, including mass spectrometry-based approaches and nuclear magnetic resonance spectroscopy . We will also highlight key studies that have utilized metabolomics to unravel the complex metabolic exchanges occurring during plantmicrobe interactions, focusing on plant-pathogen, plant-symbiont, and plantendophyte relationships . Furthermore, we will explore the potential applications of metabolomics in agriculture and biotechnology, such as the development of disease-resistant crops and the discovery of novel bioactive compounds . Finally, we will discuss the challenges and future perspectives in this rapidly evolving field, emphasizing the need for standardization of metabolomics workflows and the integration of metabolomics with other omics approaches .