A Vanquish UHPLC (Thermo Fisher) coupled to a QExactive HF quadrupole-Orbitrap (Thermo Fisher) with a heated electrospray ionization source was used for the LC-HRMS measurements. The same LC conditions were used as described in Oesterle et al. to best compare the highand low-resolution measurements, except that eluent B consisted of 0.1% v/v formic acid and 3% v/v water in acetonitrile. Thus, the gradient was adapted and started at 5.2% B, after a 2-minute hold, it increased linearly to 66% B within 10 minutes. B was then set to 97.9% and held for 2 minutes, before being decreased to 5.2% for a final 2minute hold.