Since AutoGrow tends to create population homogeneity, convergence, and undesirable moieties after longer runs , we executed AutoGrow for 10 generations until improvement began to stall. We noticed compound fitness improving quickly in the first few generations and progress slowing in later generations, so compound suitability was unlikely to improve upon further experimentation. One limitation of this study is the slight drop-off in ligand fitness in the latter half of the generations, which reduced the versatility of our screened ligands. Additionally, we found that AutoGrow works best with well-researched proteins such as PARP-1 , so the relative novelty of 6sdx may also inhibit experimental efficacy.