Further than facilitating product separation, membrane-based operations are particularly helpful to displace the thermodynamic equilibrium and enhance synthesis yields. membrane-induced equilibrium-shifting strategies have already been applied in combination with soluble (or immobilized) enzymes, in order to intensify biocatalyzed reactions (among the selected biocatalytic transformations listed in the Figure ). Here, soluble enzymes were typically employed separately from the membrane devices (i.e. membranes were at the boundary or at effluent side of the enzymatic reactors, acting as separation units) as represented in Figure , and not in a one-pot fashion.