As a result, the signal amplification rate of the system is increased according to SH-Glu > SH-BSA > SH-DNA (Figure ). Remarkably, the visual degradation between SH-BSA and SH-DNA is less than expected although the SH-BSA signal concentration is ten-fold larger compared to SH-DNA. We suspect that the 27% additional disulfides present in SH-BSA effect the overall degradation rate, which results in slower gel decomposition time.