The NMRfilter (; coordinated jointly by Prof. Ricardo M. Borges at the Federal University of Rio de Janeiro and Prof. Stefan Kuhn at University of Tartu) has an approach that originated with the intention of combining the interpretation of MS data with NMR data. The algorithm introduced by this method starts from a list of candidates (compounds possibly existing in the sample) that will have their chemical shift data simulated and compared with the users' experimental data submitted to NMRfilter. Then, a search for heteronuclear and homonuclear scalar coupling networks is performed on HMBC and HSQC-TOCSY data to define whether the signals matched in the HSQC share a unique chemical structure. In this case, it is assumed that, ideally, all nuclei of a compound will correlated with each other via 2-4 JCH. As with SMART-NMR, the dependence of an experimentally obtained database has a lower weight once the NMR data of the expected compounds can be simulated. However, this simulation is based on data cataloged in nmrshiftdb2 () and the more complete this data source, the more accurate the simulated data. In other words, more precise NMR data simulations will be achieved when the database possesses similar compounds, especially for the Hierarchical Organization of Spherical Environments (HOSE) like method. Thus, users are invited to submit NMR data from the literature to nmrshiftdb2 to populate the database for better simulations. Figure shows an example result from NMRfilter for the identification of quercitrin in the raw extract of G. biloba in deuterated DMSO. HSQC, HMBC and HSQC-TOCSY data were acquired as described at SI.1.5. Note the list of candidates suggested and the visual validation where users can evaluate both the matching rates and the peak profiles to assert their identification. Some of resulting figures and table produced by NMRfilter using the G. biloba data are available (Table .5.1, and Figure SI.5.1). Similarly to COLMARm, which uses the TOCSY spin system for candidate confirmation, NMRfilter uses heteronuclear HMBC spin system (and the TOCSY spin system via HSQC-TOCSY when available) to detect the spin fragments.