We find that in general when water is the solute, ∆G solv i,j is predicted to be overly negative. We find that ∆G solv i,j / (RT) is overly negative on average by 3.4, 3.5, and 2.4 (dimensionless units) when using SM12, SM8, and SMD, respectively. Compare this to the case of ∆G self i,i / (RT) for water predicted to be overly negative by 3.8, 4.8, and 4.3 (dimensionless units) for SM12, SM8, and SMD, respectively.