Although retrieval of bioactive conformations within a conformational ensemble is clearly desirable, it is not clear such an analysis is sufficient to determine the best approach for constructing conformational ensembles for structure-based tasks. To more directly address this question, we consider rigid pharmacophore matching against differently sized conformer ensembles. We consider generating conformers with RDKit and then unbiased sampling from energy minimized poses as well as sorting by energy and then filtering by a specified root mean squared (RMS) distance threshold, as this approach was found to be most effective at retrieving bioactive conformations.