Hence, we became curious about the potential toxicity of moldable plastic, especially because the plastics' molding process leads to dermal and oral exposure with the potential for increased risk for additives to leach and migrate when exposed to elevated temperatures. Given that moldable plastics are marketed as non-toxic and perceived to be safe by vendors and consumers, it is prudent to determine their bioactivity (if any), as well as the potential for intentionally or unintentionally added substances to transit from the material. Herein, we purchased commercially available moldable plastic products and evaluated the toxicity of the two most popular brands using a zebrafish developmental bioassay, assessed the bioactivity of their methanolic extracts using the advanced Attagene FACTORIAL platform, and characterized the extracts by highresolution comprehensive two-dimensional gas chromatography (GC×GC-HRT). Our results indicated that some products exhibit acute toxicity and bioactivity that originated from a mixture of degradation and residual oligomers of the plastic (and less likely chemical additives), conflicting with the presumed biological inertness of these polymers by vendors and consumers.