The continuous flow setup was comprised of commercially available flow equipment, automated and controlled with an orchestrating software (Figure ). In order to minimize the void volume of the transfer lines, polytetrafluoroethylene (PTFE) tubing with an inner diameter of 0.3 mm was utilized. The feed solutions of ester, amine, TBD, solvent, and the amide product were prepared in MeTHF/MeCN (9+1 v/v) and introduced by HPLC pumps. The ester, amine, TBD and solvent feeds were mixed in a 7port mixing unit (with 2 blocked ports). An automatic 6- port valve (valve 1) was utilized to either (position A) direct the reaction mixture through a stainless steel reactor coil (5.67 mL, 0.8 mm i.d.) placed on a heating block or (position B) guide it directly to a Fourier transform infrared spectrometer (FTIR). Another automatic 6-port valve (valve 2) was used for calibration purposes, to dose the amide product either directly before the reactor (position A) or after the reactor (position B) via a T-piece. The system was pressurized with a membrane-based back-pressure regulator (set to 19 bar).