In the context of ART, stem cells hold potential in several key areas: Age-related decline in ovarian reserve is a major cause of infertility. Mesenchymal stem cells and bone marrow-derived stem cells have shown promise in regenerating ovarian tissue, improving folliculogenesis, and restoring hormonal balance. Stem cell transplantation has demonstrated potential in restoring spermatogenesis in individuals with azoospermia or other forms of male infertility. Spermatogonial stem cells (SSCs) can be harvested, cultured, and reintroduced into the testes to reinitiate sperm production. Conditions such as Asherman's syndrome and thin endometrium pose significant challenges for successful implantation. Endometrial stem cells (ESCs) and MSCs have been explored to regenerate and enhance endometrial receptivity.