However, this body of research has a number of limitations. For instance, there is substantial reliance on animal models, particularly rodents. While these insights are valuable, the generalisability to the human condition is limited. Therefore, it's important for future studies to bridge the gap between animal and human research by, for example, conducting longitudinal human studies to better understand the long-term effects of THC and the role that D1 receptors play in mediating this. Additionally, some of the studies were focused on only one sex, hence it is possible that sex differences could exist in the D1-receptor mediated effects of THC. Therefore, it is important to conduct studies on both sexes in order to identify any potential sex differences regarding THC and its interaction with the D1 receptor.