3-chymotrypsin-like protease (3CLpro, also known as the main protease, or non-structural protein 5 (nsp5)), and papain-like-protease (PLpro, the protease domain of nsp3) are both proteolytic enzymes of SARS-CoV-2 which are responsible for cleaving the viral poly-protein chain (encoded by SARS-CoV-2 RNA) into non-structural proteins that are required for the process of viral replication. Adenosine ribose phosphatase (ADRP) is a domain of Nsp3 that is capable of interfering with the host immune response by removing ADP-ribose from ADP ribosylated proteins and RNA. Thus, each of these protein targets are of considerable interest for SARS-CoV-2 drug design.