To verify the universality of the Co@CS catalyst in the catalytic hydrogenation of nitrile compounds to synthesize primary amines, we expanded a variety of different nitriles in the continuous flow, including 3-polyamine and 1naphthylamine (entries 1-2) for the production of pigments, dyes, and synthetic drug intermediates. As shown in Table , we noticed that when the temperature was raised to 120 ℃ and the pressure was 2MPa, all aromatic nitriles and heterocyclic compounds showed a conversion rate greater than 99%, and the formation of the corresponding primary amines showed high selectivity. The catalytic system is suitable for substrates containing halogen groups (entry 5), acetyl groups (entry 6), ether groups (entry 7), dinitriles (entry 8), and Nheterocyclic aromatic nitriles (entries 9-10). The hydrogenation by-products and selfcoupling by-products were well suppressed, most nitrile compounds can be easily and selectively converted to their corresponding primary amines through this catalyst system. It demonstrates the applicability of graphene shell cobalt nanoparticles Co@CS as precursors for the selective preparation of amine-derived drugs in industrial applications.