EA (0.25 mmol) was dissolved in H 2 O:D 2 O (9:1 v/v) (final volume: 500 μL), and the pH of the solution was adjusted to 9.5. G3PE (5.4 mg, 0.025 mmol, 0.1 eq) was added, the pH was readjusted to 9.5, and the solution was heated at 40°C. The progress of the reaction was monitored by P-NMR spectroscopy.