As summarized in Table , seven out of 32 targets related to respiratory diseases were selected according to the criteria detailed in Section 2.2. Although the IAV M2 proton channel target did not meet the criterion of having at least 30 inactive compounds, it was selected as a test case to explore the implications of this criterion. This decision was based on the observation that many targets in the data set faced similar limitations-failing to meet the required number of active or inactive compounds-yet still achieved a MODI score of 0.7 or higher. The premise was that models built for such targets might exhibit different performance characteristics. The details of this analysis and its implications are further discussed in Section 3.4.