Nevertheless, older rule based, analytical algorithms like OSRA which was developed originally at the National Cancer Institute of the USA, followed later by a similar method called MolVec are constantly updated. OSRA is therefore still used by many groups and is also used by our company to extract chemical compounds and reactions from patent images of WO, EU, and US patents. These compounds are integrated into the search engine of the open access SciWalker application which implements a comprehensive chemical substructure search in preprints, publications, and patents.