GAFF incorporates a comprehensive set of parameters for bond stretching, angle bending, torsional, and non-bonded interactions. These parameters allow for accurate modeling and simulation of the behavior of organic molecules under various conditions (e.g high pressure, low temperature). Due to its computational efficiency, relative reliability and its relatively simple functional form, GAFF has been widely used and implemented in many popular molecular simulation software packages, such as AMBER, 4 GROMACS, CHARMM, and Tinker/Tinker-HP. Another advantage of GAFF is the public availability of its parameters. Thus facilitating its widespread use within the scientific community.