In 2005, the International Life Sciences Institute Research Foundation/Risk Science Institute assembled a working group of experts to assess NMs toxicological knowledge's current state and formulate guidelines for this newfound field's progression. This working group established the original screening mission for 'hazard identification' following NMs exposure . A bright future was predicted for the nanomaterial industry at this stage, but the risks associated with nanotoxicology were underestimated . Lux Research estimated the market for pure nanomaterials (carbon nanotubes, nanoparticles, quantum dots, dendrimers, etc.) to grow to approximately $3.6 billion by 2010 (from $413 million in 2005), and they forecasted the entire "nanotechnology impact" by 2010 to be approximately $1500 billion . In 2010, the General Accounting Office (GAO) predicted that the global market for nanotechnology-related products would grow and, by 2015, will amount to between $1 -2.6 trillion (United States Government Accountability Office, 2010). However, in 2019 the global nanomaterials market size was valued at $8.5 billion and is expected to grow at a compound annual growth rate (CAGR) of only +13.1% from 2020 to 2027 . There is still a lack of a big-scale "nano" manufacturing industry associated with producing NMs. Also, many risky materials are getting integrated into products, which do not have the potential for release yet .