Within the TS, features of high correlation (correlation limit: 0.9), as well as those containing (near zero) variance or missing values were first filtered out. Next, the Boruta algorithm was used to perform initial feature selection on the TS. Hereby, mean decrease accuracy values of real features and shuffled variants thereof are assessed for initial random forest models in order to iteratively remove descriptors with low Z scores . The reduced descriptor subset was then used to generate various commonly used regression and classification model types implemented in caret.