Combined with the very small difference in water rearrangement upon oxidation of all systems studied (Figures and), this finding shows that the insertion of an 8oxoG defect leads to only a very small difference in structural reorganization upon oxidation with respect to their individual reduced forms for both region 1 and region 2. From this data, the oxidation of native G or of 8oxoG leads to minor structural changes, which suggests that defect detection via structural indicators alone would not be sufficient. Changes in electrochemical properties provide a greater indicator of their different identities than changes in structural properties.