Broadly, there are relatively few arenes for which there is overlap in the use of aryl thianthrenium and aryl(Mes)iodonium salts as intermediates to mediate the net dehydrogenation of arenes (Scheme 11c). 1,2-Disubstituted arenes hold this unique position and we rec-ommend using the one-pot method via aryl thianthrenium salts (Table and Scheme 2) as it is the most efficient approach to convert arenes into arynes. Other substrates for which aryl thianthrenium salts are the preferred mediator are aryl halides, and in this case we recommend using our first-generation two-pot method as the aryl halide is used as the solvent in the C-H thianthrenation step. Additionally, 1,4-substituted arenes and very electron-rich arenes, such as 1,2-dimethoxybenzene 1d, require the use of the corresponding aryl thianthrenium salt as an intermediate (Scheme 11c, yellow oval). The use of aryl(Mes)iodonium salts as an intermediate is recommended for the formation of arynes from mono-substituted feedstocks, such as toluene and anisole, 1,3-substituted arenes, including pyridines, and useful functional handles such as triflate, nitro and ester (Scheme 11c, purple oval). CONCLUSIONS Herein, we described a general approach for accessing arynes from arenes. Two distinct strategies were discussed that depend on the arene substitution pattern and electronic effects. In the first case, a one-pot procedure, which passes through in situ generated aryl thianthrenium salts, was used. This is especially useful for generating arynes at remote sites on aryl halides and on 1,2-and 1,4-substituted arenes, as well as those arenes that are strong reducing agents. In the other case, a twopot process, which passes through an isolated aryl(Mes)iodonium salt, was used. This is especially useful for generating arynes from mono-substituted arenes, 1,3-substituted arenes, and a substituted pyridine. Collectively, these two strategies provide mild and efficient access to arynes within several hours from the unfunctionalized arene thereby substantively expanding the scope of arynes that are accessible. Moreover, these strategies provide opportunities for late-stage Scheme 11. User's guide to accessing arynes from arenes via net dehydrogenation.