Figure and Tables and show a summary of experimental and calculated free energies for the rate-limiting hydrolysis of the phosphocysteine intermediate (Figure ) by PTP1B, YopH and each of Chimeras 1, 3, 4 and 7, obtained from EVB calculations, as well as the corresponding electrostatic contributions to the calculated activation free energies. Figure and Table show the structures of representative stationary points from calculations for each Chimera, as well