The ability of a docking configuration to distinguish between active and decoy ligands is useful for hit discovery where the goal is to identify a sufficiently active ligand against a target. The logarithmic receiver operating characteristic (pROC) area under the curve (AUC) is calculated and provides a measure of enrichment. The logarithmic transform of the classical ROC curve biases the contributions to the AUC towards early actives recovered and is therefore particularly advantageous for evaluating early enrichment. The pROC AUC is given by equation 1: