Given this unexpected difference, we wanted to gauge whether VCD spectra of colchicine and isocolchicine may also provide evidence of larger differences in their conformers. While a few VCD spectra of colchicine have been reported, we are unaware of any published VCD studies of isocolchicine, and thus carried out studies on each (Scheme 3D/E), as well as their respective enantiomers. In these studies, both colchicine and isocolchicine appeared to have very similar ranges of dihedral angles in their VCD-contributing conformers. The only notable, major difference seemed to be in the molecules' ability to aggregate into dimers. The presence of these aggregates made it necessary to model them and combine these with the spectra from monomeric forms to get consistent data. This aggregation is well known with colchicine, and in our studies the dimer contributed to roughly 50% of the VCD spectra. On the other hand, isocolchicine dimer aggregate only accounted for roughly 12.5% of the VCD spectra, which appears to be due to differences in ability to generate appropriate hydrogen bond network. Regardless, the differences that were observed for 6 and iso-6 did not translate in any notable manner to the B-ring containing AC rings.