The strength of individual atoms change pre-and post-covalent binding. This analysis is possible by using a distributional analysis of the docking runs, and in the highest binding modes of each. The noncovalently bound structure in Figures ) or 6 changes into that of covalently bound in Figure , where all poses with scores ≥ 97 are used. The atomic total score distributions are shown in Figure . Upon comparing the color coded bound Nirmatrelvir in Figure with that of the non-covalently bound, it is seen that most of the interactions haven't changed much. The region near the functional group containing C39 and the sulfur have atom scores generally increased. This contains C32, C31, N28, and C26. Also the anchor point of O12 has shifted to extremely high. Overall, the anchor points in purple and red haven't changed and a couple of atoms have increased, O12 and C31.