Efforts have been made in the past to establish binding energies of Aβ-Zn(II) systems and, the overall coordination of Aβ-Zn(II) has also been studied . Dudev and Lim studied the preference for Zn(II) complexes to arrange in tetrahedral vs octahedral arrangements , where they were able to establish that tetrahedral coordinations are favored in the solvent phase. Similarly, in a posterior work, they were able to elucidate some relevant points for metal complexes , such as establishing the maximum number of monodentately bound Asp/Glu ligands to the metal. Nevertheless, a work where the chemical propensities for such conclusions are explained has not been performed.