In this scenario, it will be studied whether RBD of Wild type SARS-CoV-2 can bind to ACE2 when the DHF metabolite is bound to ACE2 as a ligand. This scenario uses the crystal structure built for the control scenario, RBD-ACE2-6A. The chimera software was used to remove the RBD from this complex, leaving only the ACE2 with residues from SER 19 to ALA 614. The 3D structure for the DHF was obtained from the PubChem database , using ID 135398604. The autodock tools were used to define the docking conditions for the DHF in protein ACE2: For the ligands, its corresponding torsions were established and then saved in pdbqt format. For the protein, only polar hydrogen molecules were added. Then Kolman charges were added and merged with non-polar hydrogens. The resulting protein is stored in the pdbqt format. The search space for docking the ligand was defined as a cube of 47.25 Ångströms per side, which almost completely cover the ACE2 (blind mode). Using the autodock vina software and a script bash, a thousand searches for the pose with the smallest union energy (higher affinity) were executed. The smallest energy pose that was able to produce inhibition was -8.3 kcal/mol (Figure ). With this pose the ACE2-DHF complex was built.