We downloaded the protein sequence related to lipopolysaccharide from the UniProt database. Then used the local MEME tool to compare lipopolysaccharide-related proteins with SARS-COV-2 protein ORF7a to find the conserved domains. We combined the motifs according to the structural domains of the comparison results (Table ). Table shows that ORF7a can synthesize Lipids, Core polysaccharide and O-specific polysaccharide and assemble the three molecules into lipopolysaccharide. The sites involved in lipopolysaccharide synthesis are 1-120: "MKIILFLALITLATCELYHYQECVRGTTVLLKEPCSSGTYEGNSPFHPLADNKFALTCFSTQ FAFACPDGVKHVYQLRARSVSPKLFIRQEEVQELYSPIFLIVAAIVFITLCFTLKRKT".