In the first TeachOpenCADD release from 2019, we already showed how to query the ChEMBL and PDB databases. From the ChEMBL webservice, compounds and bioactivities are fetched for the EGFR kinase using the ChEMBL webresource client (T001). This dataset is used in many downstream talktorials for common cheminformatics tasks using primarily RDKit . From the PDB webservice, we fetch a set of EGFR kinase structures based on criteria such as "ligand-bound structures from X-ray experiments with a resolution below 3.0 Å" using the biotite and PyPDB (T008) packages. The structures in this dataset are aligned invoking OpenCADD's superposition module and used to create a shared ligandbased pharmacophore model (T009). In T010, the PDB is queried to fetch all imatinib-bound structures and assess their pocket similarities -using the root-mean-square deviation (RMSD) of pocket residues -to study differences between the on-target ABL1 and its off-targets. In the 2021 release, we now have added three more notebooks covering the usage of online API webservices (Figure ).