We used this device to examine the fundamental properties of two-electrode detection systems and to optimize the electrochemical detection of the ferricyanide-mediated reaction with creatinine. We additionally designed a flow injection device for analyzing multiple clinical samples in a continuous flow format. This device relies on a flow of carrier buffer from a reservoir, through the electrofluidic channel before reaching a large-capacity absorbent pad (Fig. ). In this configuration, samples can be sequentially injected upstream of the detector, offering high throughput and continuous detection of multiple samples.