To identify the gpGVHSV amino acids nearby 4 Å distance of each ADV-conformer, a Python script was designed to be run in PyMol-opened gpGVHSV .pdb files . Preliminary ADV docking results were employed to define each of the gpGVHSV cavities by their most frequently docked 3 amino acids. The defined gpGVHSV cavities were: Bc (at the bottom of the TrD α-helix): 317D and/or 320S and/or 335K, R4-TrD (at the R4-TrD interface): 67E and/or 304H and/or 307T and Sc (at the trimer side-cavities): 296T and/or 366S and/or 411Y. The percentages of cavities targeted by thousands of ADV-conformers were approximated using a PyMol/Python script. Such script calculated the cavity percentages by the formula, 100 * number of ADVconformers in each cavity / total numbers of docked ADV-conformers (Supporting Materials / nearby11.py). Due to some overlapping, the resulting approximations accounted for ~75-90 % of the total numbers of ADV-conformers.