There are even fewer studies of AQ voltammetry in the literature. DPV and its variation DPASV (differential pulse adsorptive stripping voltammetry) were used by Barek et al. to determine the concentration of AQ derivatives and their mixtures (8AQ, 5AQ, 3AQ). A general trend was observed for all derivates -the peak potentials were shifted to less positive values with increasing pH due to the amino group protonation that makes oxidation harder in acidic media. A combination of electrochemical and computational studies suggested potential pathways for the electro-oxidation of 6AQ. They depend on pH as 6AQ has two pKa values (pKa1 = 1.63 and pKa2 = 5.59) Such experiments were not performed for 8AQ, whose pKa values ((pKa1 = -0.52 and pKa2 = 3.99) differ significantly from those of the 6AQ. The 8AQ molecule is the core of new potential anti-AD drugs , thus, it is important to comprehensively investigate the redox properties at different pH values of 8AQ compounds. The pH-dependent electrochemical properties of 8AQ are especially relevant, because the pH value can affect the uptake of the 8AQbased drugs. Therefore, in the present work, a combination of voltammetry and UV-Vis spectroscopy was used to get a better insight into the redox properties of 8AQ. In addition, quantum chemical studies exploring the energy landscapes and UV-Vis spectroscopic analysis of the possible oxidation and reduction products were performed, advancing our understanding of the electrochemical phenomena.