Grids were prepared as in previous work . Continuous rotation 3D-ED was performed using a Thermo Fisher Titan Krios G3i electron microscope operated at 300 kV under cryogenic conditions. A diffraction pattern was recorded for each tilt increment over a range of ± 60 ° at a continuous tilt rate of 1 ° s -1 . Diffraction patterns were recorded on a CETA-16M camera with an exposure time of 0.5 s per frame, forming a tilt series of 240 diffraction patterns. These conditions result in a cumulative dose of 20 e Å -2 . The camera length was set such that Bragg spots corresponding to a resolution up to 0.7 Å could be detected. EPU-D software was used for the acquisition, making use of the auto-eucentric height function to minimise sample movement when tilting to high angles. 3D-ED data were collected from crystals with a cross-section of ca. 1 µm x 1 µm. Data were indexed and integrated using CrysAlisPro 1.171.43.110a (Rigaku Oxford Diffraction, 2024) .