Docking scores aren't exact and this molecule is a good choice to examine based on the scores and distributions, both to Mpro and CYP 3A4. The docking results (output files) of all the 48:32 docking jobs are available in the Supplementary Information and can be used to examine the conformational aspects and distribution of scores. The combination of increased ligand interaction to the Mpro site by PLP 11.93, 17%, and in change in interaction to the two values 86.55 and 79 of CYP 3A4 by 2.11, 2%, or -5.44, 7%, is significant. In addition, the interaction differences between the 2 proteins goes from 13.76 to either 3.94 or -3.61; this is in activity difference of positive favor of Mpro to CYP 3A4 to positive in favor of Mpro. This is a change of Mpro-CYP 3A4 differences of 9.82 or 17. The overall increase of PLP 11.93 (17%) is roughly 1.8 kCal. This is a significant increase in protein-ligand interaction energy and could represent an increase of on-/off-binding of up to approximately x50 to x100.