(2) vw⊕el,W ⊕C . Also shown are the changes in the total solute-solvent energy, ∆ el ∆C E vw⊕el,W ⊕C , and entropy, -T ∆ el ∆C S vw⊕el,W ⊕C as solid purple and green lines, respectively, as well as the electrostatic components of the change in energy, ∆ el ∆C E el,W ⊕C , and entropy, -T ∆ el ∆C S el,W ⊕C as dashed purple and green lines, respectively. The vertical lines show the z-values of the DS -free energy minima for each system (DS -binding to the AWI and to the ACWI).