Several analogues were made with a methylene linker between the core and the aryl amine substituent (9). These were prepared via an analogous method, starting with a condensationcyclization of the appropriate α-bromoketone 1 and aminopyridine 6 to give the imidazopyridine core 7. A Mannich reaction allowed the aminoalkylations necessary for the imidazopyridine derivatives 9; 14 some anilines that were used in this reaction (8) were alkylated prior to the Mannich step (see Supplementary Information -Chemistry).