In the context of MUDPAR, the results suggest the random exploration of both WCF and nWCF structures across all the replicates. Notably, the WCF structure exhibits a population exceeding 40%, signifying a higher prevalence than the other scenarios (Figure ). In this case alongside in-phase nWCF (nWCFP1) structures, outer-phase (nWCFO) are also generated which include occasional distorted structures. Both intra and inter-flipping processes have been noticed during the simulation leading to generate both SYN and ANTI conformers alongside the conformational change through inter-flipping. Flexibility of the UBP is further evident from the RMSF plot (Figure ), which aligns with the AMOEBA results discussed above. High RMSD values are observed in the region of nWCFO structures indicating the generation of UBP-distortion mainly in the outer-phase region.