(3) Tau protein activity and function Table illustrates that tau protein possesses a variety of integrase and transposase activities. The N-terminus, C-terminus, and intermediate section of the tau protein are responsible for its transposase and integrase activities. Tau protein helps with transposition by attaching to the 5'-TXXGGGX (A/T) -3' consensus motif. This is done by DNA transposase THAP9, which is the human homolog of transposable element P transposase. It is worth noting that the consensus motif of THAP9 overlaps with the TTAGGG repeat sequences found in human telomeres. The data in Table shows that the tau protein can attach to human telomere sequences and use reverse transcriptase transposase to cut pieces from telomeres. It denote the cut region as "TAA." With Table in mind, it's clear that the transposase activity of tau protein in Table is to cut the telomere sequence and move it to the DNA sequence region that has "TAA" and TXXGGGX. The data in Table shows that the tau protein has transposase DDE activity. This is needed for the catalytic activity that cuts DNA at a specific site (TAA) and then the chain transfer reaction. Table demonstrates that retroviral integrase activity will cut off and integrate the double-stranded telomere fragment into the specific site ("TAA") DNA region. Tau protein also possesses core-binding (CB), Tyr recombinase, and integratease activities. This process is indicative of gene rearrangement. The integrated DNA region is a specific promoter and enhancer region, as demonstrated by the analysis in the subsequent section.