Even though most of these QC materials are related to typical bottom-up proteomics measurements (including using isotopic labeling or DIA), there are materials for niche applications. Well-characterized monoclonal antibodies from Sigma-Aldrich and NIST have been used in large interlaboratory studies of top-down proteomics and glycosylation analysis . For metaproteomics, mock microbial communities such as ZymoBIOMICS Microbial Community Standards, ATCC whole cell mixes and those created in the Critical Assessment of MetaProteome Investigation (CAMPI) studies () can be used for QC and SST. Note that ZymoBIOMICS and ATCC mock communities are available as cell lysates and DNA extracts, with the latter unsuitable for proteomics. Additional complex microbial materials are under development such as NIST Candidate RM 8048 (Human Fecal Material). In glycoproteomics, commercially available antibodies as well as many of the proteomes already mentioned can be used, either directly, or after releasing glycans or following • NIST offers numerous other materials that include human, animal, and plant tissues, human biofluids, etc. but are not specifically fit for purpose for proteomics. These are available directly from NIST at . • JPT Peptide Technologies (and other similar companies) manufacture reasonably complex (many 100s) mixtures of isotopically labeled peptides for many species and cell lines, which are not explicitly QC materials or standards, but could be used similar to some mentioned above. . Ideally, the methods and instrumentation that were used to generate the QC dataset are very similar to those in one's own laboratory. Datasets from well-defined metaproteomes are also available, even if the material is not, such as PXD005776, PXD005759 and PXD005728 from the 24 bacterial species in the Mix24X reference or PXD034795 dataset from the 2020 iPRG metaproteomics study .