These results help to understand the effects of the actual reactions in some indirect way. In the alchemical method, the disturbing potential leading to changes in a system originates from a hypothetical change ∆𝑍 that occurs at the center of symmetry of the electron density. The response to this disturbance involves preferentially the inner part of the electron density. This is clearly observed by the integrals I in Table : 99% of their values come from the electron density within a sphere of radius not exceeding 5 a.u. (Li). In a real situation, the disturbing potential acts from a distance to an atom or molecule and the outer sphere of the electron density is affected. In this region the contribution from the local softness s(r) will also be dominating the consequences of such disturbances. The role of hypersoftness [𝜕𝑠(𝑟) 𝜕𝑁] ⁄ 𝑣 that contributes to the integrals IN and IN2 (eq. 17 and eq. 18) will be exposed by the strengths of the external field dominating in the outer sphere of an atom and by the large volume of integration. The effects of confinement on a reaction are evident field for testing the role of this parameter. This may be especially important for calculation of the chemical effect given by the charge flow (at constant μ) ∆𝑁 𝜇 , hence reaching further that the predictions exploring the dual descriptor, defined for the closed system (canonical ensemble).