Therefore, a study utilized molecular modelling techniques to study the stability of gonadotropinreleasing hormone receptor (GnRHR) as well as GPCR with the spike protein of SARS cov-2 which resulted in strong binding and stability of both the proteins which are significantly distributed in the brain, olfactory regions and endocrine organs. Therefore, the study might explain in detail the involvement of these organs and systems in Covid-19 infection which might be the main reason of varying symptoms occurring in the patients which are affected by new strains of the virus. Moreover, some new GPCR targets might also be discovered via in-vitro studies in future for GPCRs and their role in infection . SARS-CoV-2 also disturbs or changes the secondary signaling pathways by activating the GPCRs or by direct modulation of the G proteins. This in turn modulates the transepithelial transport processes particularly those involving P a g e 12 | 56 the CFTR and NA+ channels which influences the homeostasis of the fluid layer. This secretory pathway's activation (involving the Cl-transport) further effects the absorptive pathways starting a pathophysiological cascade which causes lung edema that is the most serious symptom of Covid-19 . Furthermore, GPCRs signaling also plays a significant role in Long Covid symptoms. Research indicates that under particular conditions, the symptoms of Covid-19 continue for further long time known as long Covid. In a recent study the genes associated with long Covid were discovered and all of these hub genes were associated with GPCRs. Therefore, it could be inferred that the long Covid symptoms effects the organ systems and increases the chronic inflammation after the infection. The genes that regulate the T cell immunity using GPCRs include RET, KRAS, KIT, PTPN22, and CTLA4 and lead to several severe symptoms including autoimmunity, cardiovascular issues, reproductive and endocrine problems. Moreover, these genes were also involved in the binding of GPCRs including serotonin receptors to the G-protein and to the cortex of the cell. Therefore, the GPCR signaling pathways might be targeted for improving the treatment efficacy .