Encouraged by the successful formation of organolithium gels in vials, their stability and reactivity under ambient conditions were evaluated. Initially, PhLigel (2 equiv.) was prepared and used in a nucleophilic addition reaction with 2′-methoxyacetophenone 1 (Fig. ), the reaction chosen by Hevia et al. to study the reactivity of organolithium reagents in deep eutectic solvents. In all examples, the gel was exposed to the air for the specified time, after which the reagent was placed on the top of the gel in the vial. After rapid stirring for only 5 s, which led to the mechanical breakdown of the gel, the mixture was extracted, worked-up and analysed by H NMR spectroscopy to determine conversion to product. The gel network provides the incorporated organolithium reagents with significant additional stability in ambient conditions. Exposure of the gel to air at ambient conditions for 30 min and subsequent reaction with 2′-methoxyacetophenone 1 resulted in 92% conversion to 2 (Entry 1). In contrast, when commercial PhLi solution in dibutyl ether (1.9 M) was placed in the vial and exposed to ambient air (in the fumehood, room temperature) for 30 min, only traces of 2 were observed. Prolonging the gel exposure time to 120 min did not cause any significant loss in PhLi activity (Entries 2 and 3). However, overnight (19 h) exposure resulted in partial evaporation of the solvent (dibutyl ether) and subsequent damage to the gel network (see ESI) together with the decomposition of PhLi as evidenced by <5% conversion to 2 (Entry 4). This evaporation problem was easily addressed by closing the vial with a lid. As a result, PhLigel that was exposed to ambient air for 30 min and then stored in a closed vial overnight (18 h) still showed excellent activity: 95% conversion to 2 (Entry 5). Pleasingly, after a much longer storage time in a closed vial (25 days) under ambient conditions, the degradation of PhLi inside the gel was still negligible and 92% conversion to 2 was obtained (Entry 6). This highlights that the gel formulation can provide long term stabilisation of PhLi, even without storage under inert atmosphere. Using a similar approach, BuLi was incorporated into a gel with C36H74. The stability and reactivity of BuLigel (2 equiv.) under ambient conditions was also evaluated by reaction with 2′methoxyacetophenone 1 (Fig. ). The results obtained suggest that, like PhLi, the BuLi is highly stabilised within the gel and decomposition is limited (see ESI). Indeed, the conversion to 2 after 25 days storage in a closed vial under ambient conditions (77%, entry 3) was in fact slightly higher than the reaction using commercial BuLi solution under an inert atmosphere (70%). It was also shown that