Synthesis Part: The dinitro-fluorobenzene were treated with glycine under base condition to get product 4, which is treated with oxalyl chloride to get acid chloride product 5. The free glycine ester 6 is prepared with base treatment in 90 yield. On combining the 5 with 6 to gives the dipeptide ester 7 in 60 % yield. The diester 7 on saponification gives dipeptide 2a in 75% yield. (scheme-1) Alternatively, dipeptide acid 2a was prepared from phthalimido ethanol 8, which on oxidation to acid product 9 followed by acid chloride conversion gives 10 in 91% yield, which was esterified to MPM ester 11 by using MPM-OH, the phthalide group is cleaved by 40% monomethyl amine to get glycine MPM ester 12 in 55% yield.(scheme-2) Similarly, corresponding symmetrical dipeptides from isoleucine , leucine and phenylalanine were synthesized in four steps each to get 2b, 2c, and 2d respectively.