Using these categorisations, we then investigated the effect of precursor rigidity/flexibilty and topicity on the reaction outcome by categorising the tri-topic and di-topic precursor combinations as either flexible-flexible (FF), flexible-rigid (FR), rigid-flexible (RF) or rigid-rigid (RR), where the tri-topic precursor's flexibility label is always given first. Figure shows that for clean formation of an organic cage, either as a single topology or as a mixture of topologies, the largest proportion of successful outcomes incorporated a rigid tri-topic precursor with a flexible di-topic precursor (RF), followed by the inverse, a flexible tri-topic precursor with a rigid di-topic precursor (FR), indicating that there is a preference for clean cage formation when one precursor is rigid and the other flexible. In addition, both these categories resulted in the highest proportion of shape-persistent cages (overlaid hatched bars in Figure ), although still below half of the total number for both RF and FR combinations, whereas a RR precursor combination gave the lowest proportion of cleanly formed cages, along with the lowest proportion of cage shape-persistency. Cage reactions incorporating a FF precursor combination also showed a higher proportion of clean cage outcomes compared to RR, but still of a lower proportion when compared to precursor combinations where rigidity and flexibility are paired.