Several solutions for multiplexed combinatorial chemistry are currently available, providing microarrays based on the deprotection of optical labile or acid/base labile groups achieved by imaging or with the encapsulation of chemical monomers f or micro printing strategies. However, these platforms still lack throughput and versatility to reach a widespread use for diff erent applications that would benef it f rom the control of combinatorial chemistry at a large multiplexing scale. Electrochemically generated acid was also used for the generation of microarrays . Electrochemical strategies, in addition to f acilitate the electronic management, can ease the miniaturization of the control of chemical reactions using Silicon f abrication technologies that would allow a cost-eff ective production of chips to f acilitate the access to the technology . However, these attempts were not able to provide the necessary specifications to achieve the control of the chemistry that would allow them to reach wider use.