Application of such ligandability assessment platforms can be very broad, ranging from development of novel QMS-based techniques and site-directed fragment-based screening to identifying variants adjacent to novel ligandable pockets for allele-specific drug binding . Our results indicated that as of today, a conglomeration of empirical and computational methods may provide the highest research throughput. We report for the first time a list of apo counterparts of covalent-ligand bound PDB structures, which are of highly value for further development of platforms that can accurately recognize both apo and holo covalent sites.