Although levodopa is the most effective medication available for treating the motor symptoms of PD, in certain instances, other medications such as MAO-B Inhibitors, amantadine, anticholinergics, β-blockers, or dopamine agonists may be introduced initially to avoid levodopa-related motor complications. Modifying the levodopa dosing regimen or combining it with other medications, such as MAO-B Inhibitors, catechol-O-methyltransferase inhibitors, or dopamine agonists may help managing motor fluctuations. Reducing or withdrawing dopaminergic medication, particularly dopamine agonists, may help manage impulse control disorders. Along these lines, using levodopa and dopamine agonists for motor symptoms at all stages of PD has been proven beneficial. Dopamine agonists and drugs that block dopamine metabolism are effective for motor fluctuations. Regarding non-motor symptoms, clozapine has been found effective for hallucinations, cholinesterase inhibitors may improve symptoms of dementia, and antidepressants and pramipexole may improve depression. Table summarizes common PD medication for treating motor symptoms, with their chemical structures, indications, and an exemplary clinical trial.