In the context of this study, different esterification reactions with polyols such as EG, BDO, HDO or glycerol were performed on phenolic acid compounds to provide a primary OH group and an ester group, potentially increasing their overall antioxidant efficiency. This modification strategy could also improve (i) the thermal stability by increasing the molar masses of 4-HB and 3,4-DHB, (ii) the solubility in polymer matrices and, (iii) the matrix affinity by reducing their loss by exudation/migration or volatilization. The initial antioxidant activities of the starting molecules and synthesized products are then compared with those of resveratrol and Irganox 1076 (as reference). Figure presents the chemical structures of these molecules. As antioxidant-polymer matrix interactions can impact antioxidant activity, TPO and TPU matrix formulations were prepared with different antioxidants at varying concentrations, and then characterized. An accelerated aging protocol was set up to evaluate variations in polymer properties and estimate the evolution of the potential of different antioxidants over time and with aging.