Reaxys data were obtained under licence from Elsevier (Amsterdam, Netherlands) and extracted from flat files, version March 2023. The RDF files were converted into SDF files with ChemAxon's Molconverter and the reactions were split into single molecules. Molconverter was then used to convert the data in the SDF files into CxSMILES, which were then processed with the ChemAxon-based Structure Checker pipeline. Next, compounds with unbalanced charges, inorganic compounds, and artefact SMILES entries, representing most likely chemically invalid chemical species matching the regular expression "(\[*(\w){1,2}\]*\.){6,}|^\[H\]\.|\.\[H\]$|\.\[H\]\." were removed. The remaining entries were used to create a Reaxys ID-to-SMILES dictionary of compounds. The Reaxys XML files containing the reaction information were used with the just created Reaxys compound dictionary, our internal name-to-SMILES compound dictionary and Molconverter to reconstruct full reaction schemes from IDs and molecular names. All collected SMILES for the reaction entries were processed again with the Structure Checker pipeline. The role of each compound in the reaction was recorded. If the reaction entry did not have an explicit solvent, all reaction components were checked against the internal solvent dictionary, and if a match was found the appropriate compounds were reclassified as solvents. Multistage reaction records and reactions with no products or multiple products were removed. Entries with no reactants were deleted. Reaction entries with a component missing valid SMILES were removed. Entries where the product had the same structure as one of the reactants or reagents were rejected. The filtration resulted in 16.2M reaction entries. The SMILES in the collected records were then standardised using the ChemAxon-based Standardizer pipeline. The processed Reaxys records were combined with the filtered reaction entries from the Pistachio data set and the combined reactions were deduplicated based on the strings of sorted reaction components as InChIs.