TMPRSS2 is a member of the human type II transmembrane serine protease (TTSP) family consisting of 17 proteases that modulate a plethora of homeostatic functions including but not limited to iron regulation , blood pressure regulation , hearing development , and digestion . However, the dysregulated activity of these proteases in cancer cells promotes tumorigenesis, cancer aggressiveness, and metastatic functions . TMPRSS2's roles in homeostasis are not fully understood, but TMPRSS2 knockout mice grow without any detectable defects or impact on physiological function . Furthermore, TMPRSS2 knockout mice show reduced susceptibility to viral infection and transcriptional knockdown of TMPRSS2 decreases susceptibility to SARS-CoV-2 infection .