Enantiomers of a molecule possess identical physical properties but differ by their optical rotations, one enantiomer is dextrogyre while the other one is levogyre. In a chiral environment like biological systems, their activities could be completely different as illustrated by the (R)-(+)-and (S)-(-)-propranolol which are a contraceptive and a b-blocker drugs, respectively. The preparation of both enantiomers of a chiral molecule is crucial for many human activities (medicinal chemistry, food, perfumery, materials science…) to evaluate the possible singular properties of each enantiomer. As a consequence, the establishment of processes to access both enantiomers of a chiral molecule is highly desirable. Unfortunately, only few strategies are available starting from a racemic mixture [Fig. (1) Spontaneous crystallization of separate enantiomers, which can happen in the case of conglomerates (only ~10% of the crystalline chiral molecules) and was initially observed by Pasteur in 1848 .