Of course, the inclusion of two-body interactions on top of the conventional MFCC scheme comes with an increased computational effort that is due to the additional required calculations for fragment-fragment, fragment-cap, and cap-cap dimers. Here, we showed that by introducing a simple distance-based screening the computational efficiency can be improved and a linear scaling of the method with the number of amino acid fragments can be retained. More sophisticated screening schemes could further increase efficiency while retaining excellent accuracy, in particular if higher-order many-body contributions are also included.