where 𝑓 ! * (𝑞) and 𝑓 & * (𝑞) are the atomic scattering factors of the atoms 𝑖 and 𝑘 belonging to bead 𝑗, that are modified to include only the solvent-excluded volume term as in equation (3) and equation ( ), for SAXS and SANS, respectively. Niebling et al. have effectively applied the SBA with the Martini 2.2 33 coarse-graining scheme to derive SAXS bead form factors for proteins, and we have further extended it to nucleic acids . Successively, we have employed SAXS to restrain both Martini simulations as well as atomistic simulations of proteins and nucleic acids in a hybrid scheme called hySAXS. In this approach, the simulation is performed at atomic resolution, while the SAXS intensity of the respective frames is calculated on a coarsegrained model .