Receptor 1 was prepared from commercially available 3acetylbenzonitrile, of which the ketone was protected, and the nitrile subsequently reduced to afford benzylamine 5 (Scheme 1). After reaction with 1,1′-carbonyldiimidazole (CDI), monosubstituted carbamoyl imidazole 6 was reacted with o-phenylenediamine to give intermediate [7] and subsequently deprotected in situ to generate bis-urea strap 8 in good yield. Strap 8 reacted in neat pyrrole to form precursor 9, which was subjected to a condensation reaction with acetone to afford strapped calix [4]pyrrole receptor 1 in moderate yield. Reported compounds 2 and 3 (Figure ) were synthesised as control compounds, representing either the strap (2) or the calix [4]pyrrole base (3) components of receptor 1 (Scheme S1).