In conclusion, our study delved into the molecular properties and pharmacological potential of various cannabinoids present in cannabis smoke, shedding light on their interactions with key protein targets, ADMET properties, and potential metabolic pathways. Through molecular docking experiments, we elucidated the binding modes and affinities of smoked CBD flower products to PPAR-γ, PAK1, CB1, CB2, and GPR119 proteins, providing insights into their agonist or antagonist effects. Our findings reveal intriguing ligand-protein interactions, with some cannabinoids exhibiting favorable binding energies and stable ligand-protein complexes.