The solubility of LCST type polymers in water primarily depends on both hydrogen bonding between water -polymer repeating units and inter-or intramolecular polymer-polymer interactions (hydrogen bonding and hydrophobic interactions). D2O forms stronger hydrogen bonds with polymers compared to H2O, improving solvation. On the other hand, in D2O, the hydrophobic effects are intensified compared to H2O, which should decrease solvation. Indeed, the Tcp of LCST-type polymers differ in D2O compared to H2O. For example, Chen et al. found that for linear PEtOx solutions (Mw: 12 kg/mol), the Tcp was 3 °C lower in D2O. Similarly, Diab et al.