We observed marked intra-target early enrichment among the top-ranked poses of the model trained on cross-docked crystal structures compared to the model trained on cognate receptors (Fig 3A, top-1 54% (pink) vs 45% (black). While the jump in performance could be attributable to a larger training set size, the reduced AUC suggests that the cross-docked model less easily distinguishes good poses from bad poses despite the larger data set. However, the model is more confident about good poses, likely because similar good poses occurred across multiple receptor conformations whereas invalid poses were reproduced less across receptors.