reorient upon binding, the correlation between the work and the orientation of each individual side chain will be reduced, making it more difficult to identify slow motions. Furthermore, the metric is prone to false positives due to accidental correlations that can cross significance testing thresholds, as illustrated in this comic. If 200 residues are predicted not to correlate with the work values, a 5% false positive rate will mean that there are 10 false correlations. Careful inspection (e.g. considering proximity to the binding site) and cross-validation with replicates can help ensure apparent correlations are not spurious.