Opening of sulfur crosslinks in soft-materials (e.g. hydrogels) has been frequently realized in the presence of reducing agents (e.g. trivalent phosphorous reagents ) and through thiols via thiol-disulfide exchange , whereas examples in which mechanical stress or force 41 is used as trigger are rare. To further evaluate our system, we were interested to see if compound 1 is capable of sensing mechanical impact through damage-generated radicals and subsequent TPPTS release to initiate the amplification cascade. Applying mechanical impact on disulfide bonds results in homolytic disulfide scission to produce the corresponding thiyl radicals. These radicals can form thiols by abstracting hydrogens from water or other donor molecules. These newly formed thiols will initiate the amplification system by releasing TPPTS from 1.