To conclude, the point groups were found to play a fundamental role in adjusting supramolecular receptor systems for e.e. determinations by the NMR method. Four atropisomers containing different point group notations were thoroughly investigated by NMR with (S and R) camphorsulphonic acid pinpointing the 22 rotamer as the most sensitive receptor for chirality detection. It was found that the ∆σmax value of N-H signals can reach 0.653 ppm, a three-fold greater splitting than any known pro-CSA. Such enhanced sensitivity towards the chiral components allows for readily available and exceptionally detailed enantiomeric excess detection at room temperature by NMR.