In the current work, we have utilized computational simulation to investigate zinc transporter (ZnT) proteins responsible for transporting zinc outside cells. Inhibiting the transport of zinc outside cells is correlated to diabetes management. Molecular docking simulations on 5249 chemical compounds (ligands) were performed at the cytoplasmic opening of the ion channel, aiming to inhibit the zinc ion efflux. Out of 5249 chemical compounds, the top five ligands were selected that make strong potent interaction the top five ligands were selected that make strong interactions with ZnT protein. Pharmaceutical properties of these ligands also showed drug likeliness. This research work will help in designing novel therapeutic strategies against the disease.