We calculated physicochemical properties of pharmaceutical interest for the LANaPDB compounds and compared them with two reference datasets: COCONUT and FDA-approved small-molecule drugs. Figures and show the distribution of the calculated physicochemical properties: SlogP, molecular weight (MW), topological polar surface area (TPSA), number of rotatable bonds (Rb), hydrogen bond acceptors (HBA), and hydrogen bond donors (HBD). The violin plots (Figures and) are marked with a horizontal line the limits of some drug-likeness rules of thumb: Lipinski's rule of 5 (Ro5), Veber's rules, GlaxoSmithKline's (GSK) 4/400 rule, and Pfizer 3/75 rule. The improvement of some drug-like parameters is attributed to the fulfillment of these rules of thumb. In Figure are not appreciated noticeable changes in the distribution of the physicochemical properties of LANaPDB compared to the previous version. The above can be attributed to the fact that the terpenoids remain as the prevalent compounds (Figure ). Moreover, the LANaPDB and COCONUT distribution of the compounds (Figure ) is very similar for all the physicochemical properties, except for the rotatable bonds whose distribution in LANaPDB is focused in a region with less rotatable bonds.