Next, we sought to determine if the inclusion of guest-binding within the junctions of polyMOC gels would affect their stress relaxation dynamics. Stress relaxation dictates the temporal response of a material to applied forces and is a key parameter in the design of polymer networks for use as adhesives, injectable biomaterials, and cell scaffolds. We reasoned that the inclusion of host-guest binding may serve to stabilize the MOC junctions against the solvent-or ligand-assisted exchange reactions at palladium that lead to microscopic network restructuring and ultimately macroscopic stress relaxation, which would be a unique feature of nested MOC junctions compared to traditional supramolecular networks. Indeed, stress-relaxation studies conducted at 25 °C show that the presence of host-guest binding leads to an increased characteristic relaxation time concomitant with the strength of guest binding, up to approximately an order of magnitude greater for poly(DAQ⊂MOC) as compared to poly(OTf⊂MOC) (Figure ). To gain further insight into how guest-binding affects stress relaxation, variable temperature experiments were performed, and an Arrhenius analysis was conducted (Figure ). The extracted activation energies for each gel are listed in Table (see Supporting Information section "Stress Relaxation Modeling" for experimental and data fitting details). Activation energy was found to trend upward with guest binding strength, indicating that the critical ligand dissociation step required for stress relaxation has a higher activation barrier for more stable host-guest complexes.