To this end, the present work constitutes the first quantum dynamical study of photo-induced degradation mechanisms of perfluorooctanoic acid (PFOA) and perfluorooctanesulfonic (PFOS) contaminants. We first give a brief description of the RT-TDDFT formalism and our computational methods, which includes our custom implementation of optical electromagnetic fields in the GPAW software package. We then present a series of RT-TDDFT calculations and electronic diagnostics showing that this photo-induced process selectively degrades PFOA/PFOS while keeping the water molecules in the surrounding environment intact. Our results are complemented by a variety of analyses, including real-time electronic properties and timedependent orbital occupations that explain the underlying excited-state mechanisms of the degradation process. Finally, we conclude with a discussion and summary of our results, with additional perspectives of future applications of RT-TDDFT that can have a broad impact in probing photo-induced interactions of environmental contaminants.