The major bottleneck in HTE synthesis lies in the challenge of isolating and purifying reaction products once experiments are performed. Despite this bottleneck, the landscape is evolving, with various practical tools emerging to streamline purification processes. From prepacked silica gel tubes to the precision semi-preparative liquid chromatography, and the versatile capabilities of various scavenger resins, laboratories are witnessing a surge in options for efficient high-throughput purification, particularly in chemical synthesis on a modest scale. A change in thinking beyond conventional purification methods presents an opportunity to revolutionize HTE flow platforms. A completely novel design, differing from established isolation and separation techniques, holds the promise of not only enhancing the efficiency of HTE flow synthesis but also paving the way for more sustainable growth in this research area.