The performance comparisons of different methods on Suzuki-Miyaura cross-coupling reaction optimization are shown in Fig. . Fig. illustrates the highest yield achieved (%) so far at different iterations. Since the numerical values of the yields are very close, especially as the number of iterations increases, a zoomedin panel of the last five iterations is shown for better visualization. In Fig. , the corresponding ranks of the yields at different iterations are presented. These ranks are derived from the known yields of all possible combinations (3,696 in total) .