Due to the drastic reduction of number of computed interactions (i.e., non-native and explicit solvent interactions are not taken into account), SBM simulations converge extraordinarily fast compared to standard MD, allowing, for example, simulating the folding of a small protein in equilibrium conditions by using only modern personal computer hardware, but also allowing to explore other biomolecular processes involving considerable energy barriers. Even though SBMs simplifications can overlook relevant pathways that include non-native interactions or explicit solvent definitions, an idealized study can serve many purposes before moving to more complex and definitely more expensive representations.