to the parent compound 1a (7.6 µM). The activities against LmPTR1 are distinctly lower -up to 57% inhibition at the tested concentration for 2d with meta-Br (Tab. 2). However, all compounds of series 2 show rather low activities against T. brucei (Tab. 2) -mostly in the range 27%-39%, with the exception of the moderately active 2b (51%). The tested compounds from this series are also inactive against L. infantum, similarly to the parent compound 2a.