duce the molecular shape more accurately. This also includes giving preference to certain sizes of beads, for example for aromatic molecules (tiny beads) or aliphatic ring structures (small beads). The mapping, which was applied to the fragments is shown in Figure in the supporting information. An important part of the whole parametrization is the determination of non-bonded interactions. In Martini, a building block approach is used with pre-defined beads for certain atom groups. This means that all interactions are defined via a discrete set of possible interaction parameters. These parameters can be fine-tuned, based on thermodynamic properties such as transfer free energies or miscibility trends. In the present case, for most of the atom groups, standard beads were applied, which are beads that mostly reflect the behavior of the corresponding atom group in an isolated form. An explanation for every bead that was applied can be found in Table in the supporting information. Some of the main bead classes in Martini 3 are polar (P), intermediate (N), and apolar (C). Each of these classes contains 6 beads with different degrees of polarity, ranging from 1 (low polarity) to 6 (high polarity). In contrast to regular beads, small and tiny beads are represented by the first letter with S and T, respectively. For further information on the available bead types, labels and the nomenclature, please refer to the supplementary information of the main publication of Martini 3 31 , sections A1 and A4.