Despite its broad applicability and success, the Martini lipid models have shown certain limitations , particularly in accurately capturing the phase behavior of ternary lipid membranes . For example, the inability to adequately represent certain lipid mixtures' liquid-ordered and liquid-disordered phases has been a notable challenge . Additionally, the Martini 2 model occasionally struggles with reproducing gel and ripple phases, including their temperature phase transitions, lipid packing, and tilting . Other significant issues have been the model's difficulty in accurately representing pore formation and the mechanical properties of membranes .