In many disciplines, such as synthetic, medicinal, and environmental chemistry, knowing the aqueous solubility of organic molecules is critical . This importance is exemplified by the following applications: (i) Flow batteries (FBs) require highly soluble compounds , as higher solubility allows the solution to store more electrons, thereby enhancing the energy capacity . (ii) In drug discovery, soluble compounds are essential to minimize side effects . When working with poorly soluble drugs, advanced delivery techniques are necessary to improve therapeutic efficacy, which can complicate the development process .