A virtual screening approach for compounds of the DrugBank demonstrated the high-throughput applicability of our models and suggested additional drugs for future formulations. Given an ensemble of models with multiple thresholds, the tool POxload will be used as complementary in silico tool alongside our own research to rapidly provide a first assessment of the drug loading properties of potential new formulations and thus potentially narrow down the necessary experimental workload. As such, the herein developed tool can be seen as an easily-applicable pre-filtering method for the detection of drugs that could be efficiently formulated with already established pOx/pOzi-based delivery systems, prior to time-intensive experimental measurements or large scale molecular dynamics simulations that could be necessary for dissecting the optimal drug-polymer combination more precisely. Vice-versa to predicting the loading of a drug with known polymers as vehicles, we envision that collection of large amounts of additional data -through experiments, data mining approaches , ).