The is required to correct ion trajectory with increasing SV, typical of hard sphere collisions. This gain in peak capacity at higher SV enables baseline separation of NCOC from BZE with resolution of 1.26 at SV of 800 V (198 Td). Regarding the tramadol metabolites, peak capacity increase from 300 to 700 V (Peak capacity (PC) 0.1 to 0.46) enabling partial resolution between the isomeric pair (Resolution (RS) 0.93), but above SV 700 V signal vanishes. For the isomeric pair THC/CBD (m/z 315) the peak capacity increases from PC=0.01 to PC=0.27, unfortunately it is not sufficient to resolve the isomeric cannabinoids even at high E/N of 223 Td (RS=0.12). See Supplemental Information Figure for a more detailed view of the separations, presented as CV vs signal plots.