The current methods to resolve enantiomers are expensive and not universal. These methods typically require changes in synthetic pathways or separation in chiral environments. Synthetic methods will often utilize acid-base reactions that form diastereomers, while subsequent reactions will recover the pure enantiomers from the resolved diastereomers. This allows resolution of the enantiomers via classical techniques due to distinct physical and chemical properties of intermediates. There has also been significant progress on separating enantiomers once they have been formed by their primary synthetic reactions. In this case, the enantiomers can be resolved through chiral environments. Chiral environments often involve chiral chromatography 2,4,7 where enantiomers have distinct intermolecular interactions with a chiral stationary phase or with a chiral solvent. In this paper, we develop an explanatory "screw" model for predicting the shear-flow separation of enantiomers using a set of hydrodynamic calculations on the structures of the molecules.