There are factors that need to be considered in the analysis of the chiral mixture screening database. First, since the mixtures were screened in ambient conditions, every sample has some amount of environmental water, but sample size (~0.1 g) precludes quantitative water determination. This means that many of the mixtures in the database should be considered a ternary mixture of HBA:HBD:water, and it is unclear what role water content plays in the formation of the liquid at 55 or 20 °C. Second, only a limited number of mole ratios have been explored for each of the mixtures, where different molar ratios may form liquids at 55 or 20 °C.