DataWarrior evolutionary docking was selected to generate large amounts of ligands fitting the 960-1010 targeted Omicron inner-cavity. Preliminary evolutionary results with the selected TTT-parent explored possible simplifications varying their central core ring of 6 atoms (three Carbons and three Nitrogens) (top 2D structures at Figure ) with core alternatives such as trimeric cores of three Nitrogens, three Carbons or one central Nitrogen. However none of the children generated from any of the core alternatives mentioned above, reduced the initial TTT-parent binding-scores (results not shown). After many additional tests, optimal fitting criteria were adjusted to maintain the TTT-parent 6-atom ring structure allowing random evolution of any atom (including the central 6-atom core). Additional fitting criteria were included maintaining molecular weights, reducing hydrophobicity, maintaining the maximal number of rings and allowing for a higher number of Nitrogen and Oxygens (Figure , legend). According to the results, most of the randomly generated and fitting selected TTT-children predicted lower docking-scores when compared to their corresponding TTT-parent (compare dashed line and circle profile at Figure