For further stability analysis, we investigated the compactness of the protein by calculating its radius of gyration (Rg). Basically, we are investigating the distribution of protein atoms from their centre of mass, which will give us a direct indication of the folding and the stability of the protein. SARS-CoV-2 Mpro showed consistent compactness when complexed lamellarin H with a slight increase in compactness for some instances throughout the simulation, indicating the overall structural stability of the complex, as shown in Figure .