heavy atom count, lipophilicity, charge, and format. An additional organizational dimension, layer, allows the database to be prepared in parallel and independently as separate layers, allowing scalability. Molecules are packaged into files of up to 5000 molecules each, intended for a single docking calculation on a single CPU. ZINC is also distributed in more ways to make it easier to access. ZINC is available in Amazon's AWS cloud, in Oracle's OCI cloud, as well as on our server at UCSF. From UCSF, ZINC can be accessed using curl, wget, Powershell, rsync, and globus.