More molecules are listed in Table which follow the conditions 1,2, and 4. Out of the complete set of 15922 there were 76 which satisfied conditions 1,2,4. Also, docking calculations is not an exact calculation, but being based on a genetic algorithm with dihedral angles is non-deterministic. A cutoff factor of 1.02 was used to multiply the score of the Ligand GA molecules in comparing with Nirmatrelvir. This conservatively raises the docking score of the molecule to both Mpro and CYP 3A4, and decreases the number of screened molecules than without (122 with 1.0 cutoff factor). The set of 76 molecules all have a stereoisomer (15922 total from the 76) that has a higher binding score than Nirmatrelvir while satisfying ADME restrictions. There are many molecules out of 15922 with higher scores, as seen in the distribution Figure (c).