show the excellent softness and flexibility of the soft gold ultramicroelectrode, as it could even be bent like a hairpin. For testing its' quality, cyclic voltammetry (CV) experiment was performed in 2 mM of FcMeOH. A commercial SECM (Ametek, USA) ran under VersaStudio software (Ametek, USA) was used. All SECM experiments were performed in a three-electrode arrangement under RT using an Ag wire as quasi-reference (QRE) and a Pt wire as the counter electrode (CE). All potentials reported here are given versus the Ag QRE. Data sets were treated and analyzed using the MIRA software (Gunther Wittstock, Carl von Ossietzky University of Oldenburg, Germany). We adopted the contact mode for the SECM imaging of the distribution of EGFR and IL-6 in tissue slices. The soft probe was slightly contacted with the sample surface during forwarding line scans and recorded the current values.