While their status as gatekeepers of quality would be a moot point, there is nonetheless an assumption that by specifying stringent acceptance criteria for authors (i.e. journals setting their individual bars) the higher standard ones could be considered as de facto gatekeepers of the essential core knowledge for CDEV and ADEV. However, an important caveat is that the terms 'lead structure', development candidate', 'clinical candidate', 'orally bioavailable', 'potent' and 'specific' are, in practice, inconsistent author-declared classifications with only implicit, rather than explicit, blessings of the journals. Leaving aside the contentious issue as to how journal quality can be defined (e.  The ACS Journal of Organic Chemistry (J Org Chem) has ~ 33,000 PubMed entries and a 2017 impact factor of 4.8. This is a gateway journal in the sense that while inherently low in bioactivity reports (i.