Herein, we demonstrate AIE-based functionalized nanogels as versatile nanocarriers that effectively integrate active homologous targeting, dual thermo-/pH-responsive drug release and NIR light-triggered hyperthermia, and in vivo visual fluorescence imaging/photothermal imaging, for precise chemo-photothermal synergistic therapy (Scheme 1). To this end, as indicated in Scheme 1a, thermo-/pH-responsive polymer backbone, poly (Nisopropylacrylamide-co-acrylic acid) (abbreviated as PNA) nanogels bearing thermo-and pHresponsive segments were first synthesized through precipitation polymerization. Then TPA-NDTA (abbreviated as TN) as an AIE photothermic and contrast agent, was encapsulated into the cross-linked networks of PNA nanogels to produce P-TN nanogels; subsequently, doxorubicin (abbreviated as Dox) as a positively charged anticancer drug in clinic, was incorporated into nanogels via electrostatic interactions to give P-TN-Dox nanogels. Finally, the isolated tumor cell membranes inherited from the 4T1 mammary tumor cells were cloaked onto the surface of P-TN-Dox nanogels via ultrasonication and physical co-extrusion to yield the final formulation of P-TN-Dox@CM nanogels. As shown in Scheme 1b, the source tumor cell membrane camouflaged nanogels (P-TN-Dox@CM) can actively target and specifically recognize the tumor tissues on account of the tumor cells expressing surface adhesion proteins with homologous adhesion domains. After P-TN-Dox@CM nanogels are endocytosed by the targeted tumor cells, a burst release of Dox is triggered by low pH to induce tumor cell death. Upon NIR laser irradiation, the photo-induced hyperthermia can activate severe cytotoxicity; concurrently, the local temperature elevation can also boost drug release, which synergistically produces effective chemo-thermal therapy with thorough tumor ablation. Over and above, the AIE property of TN endows P-TN-Dox@CM nanogels favorable for the high deep penetration and spatio resolution fluorescence imaging and photothermal imaging in real-time and on-site. Thus, the intelligent P-TN-Dox@CM nanogels can serve as a versatile nanoplatform that integrates multimodalities for active-targeted and dual-modality imagingassisted precise chemo-photothermal synergistic therapy.