Extensive studies have detailed the formation of organs ; here, we focus on the plasticity of developmental trajectories. Given the challenges in developing material-producing tissues, it is important to note that organoids can often be cultivated using multiple methods, providing alternatives if one approach fails. For instance, intestinal organoids can be derived either from adult stem cells (ASC) , or from embryonic pluripotent stem cells (PSC) and iPSC 345 ; each using different developmental trajectories. The organoid's maturity is affected by its cellular origin 234 , but can be partly compensated by longterm cultures 346 and co-culture interactions 314 . Organoids can still be grown in tissues lacking ASCs in vivo, such as the heart or brain , by leveraging cellular plasticity 349 . Many culture methods have been developed but the field needs standardized protocols and unified representations 321 . For instance, signaling pathways, cell differentiation trajectories 350 and other biological processes can be formalized into workflows with step-by-step descriptions . We suggest that similarly, a systematic definition of organoid developmental trajectories in standardized workflows would help future discoveries. Such workflow description is generally useful for computational approaches and may eventually contribute to developmental trajectory inference, as it is currently the case with signaling pathways . Organoid protocols only use a few signaling factors to trigger stem cell self-organization 353 . Developmental workflows should emphasize key induction events, such as differentiation signals, symmetry breaking, or pattern formation . The triggers for these events can be transcription factors, chemical gradients, or bioelectric fields 355 . Specific to materialproducing organs, workflows can also describe biomolecule synthesis and assembly.