On the other hand, the RDFs are similar in nature in urea-water and urea-TMAO solution. A relatively high water density around cavity molecules causes the solvation of cavities more unfavorable in urea water or urea TMAO water relative to TMAO-water or pure water. Upon addition of urea in water-TMAO mixture, the water density around cavities is significantly enhanced in water-urea-TMAO mixture for both force-fields. On other hand, on addition of TMAO in water-urea mixture, the water density in the solvation shells of cavity molecules is significantly increased for Garcia's model of TMAO while it is slightly enhanced for Netz model.