The MS data were converted from. RAW (Thermo) standard data format to mzML format using the MSConvert software, part of the ProteoWizard package . The converted files were treated using the MZmine software suite v. 3.1.0 . The parameters were adjusted as follows: the centroid mass detector was used for mass detection with the noise level set to 1.0E5 for MS level set to 1, and to 0 for MS level set to 2. The ADAP chromatogram builder was used and set to a minimum group size of scans of 5, minimum group intensity threshold of 1.0E5, minimum highest intensity of 5.0E5 and m/z tolerance of 10 ppm. For chromatogram deconvolution, the algorithm used was the wavelets (ADAP) . The intensity window S/N was used as S/N estimator with a signal-to-noise ratio set at 15, a minimum feature height at 5.0E5, a coefficient area threshold at 110, a peak duration ranges from 0.1 to 0.5 min and the RT wavelet range from 0.02 to 0.06 min. Isotopes were detected using the isotopes peaks grouper with a m/z tolerance of 15 ppm, a RT tolerance of 0.05 min (absolute), the maximum charge set at 2 and the representative isotope used was the most intense.