In the context of the DNA-mediated hole transfer scheme, it is crucial to understand whether defect-induced differences in DNA redox chemistry within the NCP are substantial enough to be leveraged by BER enzymes for the detection of lesions. Such knowledge would help in understanding if the detection of defect DNA bases by BER enzymes could in principle also occur within the NCP structure, or if -as recently suggested -it is restricted to processes during which the DNA is found in a unfolded state, such as during replication, which would clearly hamper the overall detection efficiency. Under this scope, we investigate here the redox properties of native and 8oxoG containing DNA in its fully packed form within the NCP using an analogous computational approach as for our recent study of the corresponding redox properties of free DNA. To this end, we have performed hybrid QM/MM MD simulations of native and 8oxoG-containing NCP systems in biologically relevant conditions, including an explicit representation of water and Na + and Cl - ions at physiological ionic strength. Two different G-rich locations were considered within the NCP, differing in the extent of solvent exposure. For both cases, it is shown that the presence of an 8-oxoG decreases the redox potential by approximately 1 eV, suggesting that the defect-induced effect on redox chemistry found in native DNA is present to a similar extent in chromatin.