NGT efficiently identified novel, potent and selective antagonists for Melanocortin Type 2 Receptor (MC2R) in a CSL containing over three trillion compounds. MC2R is a G-protein coupled receptor primarily found in the adrenal cortex. Modulating the activity of MC2R impacts the production of cortisol, which could be beneficial in medical conditions associated with dysregulated cortisol levels, such as adrenal insufficiency or Cushing's syndrome .