Microorganisms often encounter various extreme challenges of the environment, which trigger continual adaptations of the cell membrane . Under physiological condition, cell membrane is fluidic, which is necessary for performing its role in different cell biological processes. Drastic reduction of temperature is detrimental to the cell membrane since it may cause fluid-to-gel phase transition of the lipid bilayer . In response to the environmental stress factors, the microorganisms have developed some key strategies, such as lipid remodelling homeoviscous adaptation , introducing small polar organic molecules (osmolytes) , etc.