Mixed approaches in Socratic questioning extend the structured, iterative reasoning of chain-ofthought prompting by dynamically integrating multiple Socratic principles into a cohesive framework (figure ). Unlike single-principle approaches that focus on isolated aspects, mixed approaches allow for seamless transitions between defining terms, testing assumptions, and generating hypotheses. This adaptability mirrors the interconnected and dynamic nature of human reasoning, making it especially suited for tackling complex and evolving challenges in chemistry.