In summary, we have demonstrated a versatile and convenient hand sprayer-based approach on yielding transparent surfaces that afford potent bactericidal activities. The durability, along with the re-applicability of the coatings without compromising transparency, provides the reliable, long-term protection. Compared to the usual options, the features of this coating strategy should integrate well into the common practices of the general public, and thus could significantly benefit public healthcare against severe pandemics. Following the proof of concept, we welcome further studies on upgrading this approach towards attaining versatile efficacy against other fomite-transmissible pathogens, including gram-positive bacteria and viruses (i.e., SARS-CoV-2) for a more practical prevention measure against current and future pandemics.