Again, since the (H 2 O) 8-10 systems are all cage-like, the A stabilization is not present or not as favourable as in the open water cluster structures. Setting aside the methyl acetate, which is the less symmetrical and the most structurally complex of the probes, all organic molecules show a similar distribution of binding energies (see also the additional data presented in the SI). We can expect that AOC reactions involving the moieties present in our probes would behave similarly when interacting with water molecules. We imagine real water-organic reactions involving significant dynamics in HB formation between the probes and the water systems with which they interact resulting in fluctuations in BE over time. We suspect that the maximum strength of the BEs achievable will likely be quite close those calculated for the probe-(H 2 O) 7 . Of course, entropy effects will impact the nature of the complexes formed in real systems.