The solubility values, expressed as log units of molar solubility (mol/L), range from -12 to +2, representing aqueous solubilities measured at 20°C-25°C. LogS quantifies the aqueous solubility of a compound, indicating how much of the compound can dissolve in water under specific conditions of temperature and pH. A lower logS value signifies lower solubility in water, while a higher value reflects greater solubility. Compounds with 0 and higher solubility value are highly soluble, those in the range of 0 to -2 are soluble, those in the range of -2 to -4 are slightly soluble and insoluble if less than -4. Notably, around 85% of drugs exhibit logS values between -1 and -5, with virtually no values below -6 . This range appears to balance the polarity needed for adequate aqueous solubility and the hydrophobicity required for membrane permeability . Most of the collected data fall within this target range, which is typically associated with pharmacological efficacy. While some outliers are present, the overall distribution aligns well with the expected values for drug-like compounds.