After the end of the challenge Dr. Bernhard Rohde described results of his submission and indicated that there was a variability of the proportions of insoluble compounds per plate. He determined the information about plate and position of each sample on the plate from the data labels based on assumptions of the enumeration of compounds within each assay. His submission calculated higher scores QWK=0.198 and 0.217 for Leaderboard and private sets, respectively. The label-specific descriptors were not accepted as eligible information by the challenge organizers and thus this submission was not listed amid the challenge winners. To understand this organizers' decision, it is essential to understand that for a robust prediction of an unseen molecule solubility, we must not include prior or biased knowledge.