In this work, we introduce an ensemble docking workflow using Icolos, in which ligands are docked against multiple receptor grids, which can be constructed from either different crystal structures or central member structures obtained from a molecular dynamics trajectory. In our experience, ensemble docking can lead to substantial ligand enrichment compared to a single grid, especially where there is significant receptor flexibility. The full workflow consists of the following steps, and is summarised in Figure • Ligand embedding, enumerating possible protonation states, stereo-chemistry and tautomers, • Docking against multiple grids • Filtering and reporting back the best score per compound across all receptor structures.