Supramolecular polymer networks are formed through non-covalent interactions between (macro)molecular strands and junctions to give a wide range of structures and properties from elastic materials to highly ordered framework materials. Compared to covalently cross-linked polymer networks, the reversibility of non-covalent interactions in supramolecular polymer networks enables distinct functionalities (e.g., self-healing 1 , stress dissipation 2 , responsiveness to chemical stimuli ) and enhanced mechanical properties (e.g., extensibility and toughness ), which facilitate a wide variety of applications, such as adhesives, biomaterials, and stimuli responsive materials. Researchers have combined multiple supramolecular interaction types or strengths to construct new materials with advanced functions (Figure ). To date, however, the interactions used (vide infra) have been introduced as discrete, isolated interactions where the (thermo)dynamics of one are independent of the other within the supramolecular network structure. For example, Stang and coworkers have used combinations of orthogonal metalligand coordination (e.g., Pt 2+ -pyridine metallacycles), host-guest (e.g., ammonium/crown-ether complexes), and hydrogen-bonding interactions to construct multi-responsive supramolecular polymer networks that display self-healing behavior and stimuli-responsive gel-to-sol transitions under conditions that weaken relative bond strengths, increase bond exchange rates (e.g., heating), or that dilute cross-linking functionality (e.g., addition of potassium salts to sequester host-guest cross-linking sites). Since host-guest binding, hydrogen bonding, and metalligand coordination interactions are independent in these systems, attenuating any of the interactions leads to network deconstruction. Moreover, strengthening only one interaction does not increase the overall network stability to a competitor for the others. Similarly, others have reported materials that display pH or solvent responsiveness made possible by a combination of host-guest and electrostatic or hydrogen-bonding interactions. Nevertheless, while materials built from such interactions intrinsically have the potential for highly selective stimuli-responsive bulk behaviors triggered by the presence of selective guests, such stimuli have so far been strictly limited to causing cross-link displacement resulting in a decrease in stiffness or network dissolution. Others have combined supramolecular interactions of the same type but varied strength (e.g., a weak and a strong coordination bond) to fabricate supramolecular network materials (Figure , right). For example, Holten-Andersen and coworkers as well as Craig and coworkers have prepared end-linked or side-chain linked metal-ligand coordination gels, respectively, by combining mixtures of metal ions (e.g., Ni 2+ , Zn 2+ , Cu 2+ , Pd 2+ , Pt 2+ ) with a polymer-bound ligand. A similar concept has recently been demonstrated in the context of Pd 2+ and Pt 2+ metalorganic cage (MOC)-crosslinked polymer networks. Nevertheless, while the combination of multiple supramolecular bond strengths through mixing metals enables functions such as maintaining constant stiffness with widely variable stress relaxation rates, the reliance on independent interactions limits the functions of these materials similarly to those using different supramolecular interactions as described above. Overall, the use of combinations of independent supramolecular interactions places inherent limits on the functional scope of supramolecular polymer networks.