The quantities used as input for fitting Equation 1 in the main text can be found in SI Table . The parameters k 1 to k 7 were fit in stages. The value of k 1 is simply the Lennard-Jones component of the hydration free energy of methane per unit area, for the reasons indicated in the main text (also, see SI Table ). The values of k 2 and k 3 , corresponding to the contributions of the hydration free energy per water-carbonyl and water-amine hydrogen bonds, respectively, are from ref.