One drawback for the use of MEW is that typically high temperatures are needed to obtain a sufficiently low viscous polymer melt, which can be further processed. To lower the fabrication temperature, plasticizers can be used, which can improve the processability by reducing the polymer melt viscosity. However, some requirements need to be met: low volatility, high temperature stability and good compatibility with the polymer. If the plasticizer is used in an ASD, the influence of plasticizer on the dissolution rate of the drug if of interest. Importantly, plasticizers was shown to influence the melt viscosity of different grades of poly(vinyl alcohol) to a different extend, which suggests the need for optimization for every polymer-plasticizer combination. Previously used plasticizers are small molecules, like citrate derivates , mono- and polysaccharides , glycerol or PEG based compounds or even small molecule drugs or pharmaceutically active ionic liquids . The aim of this work was to explore the influence of the plasticizer and drug on the viscosity on four amphiphilic ABA triblock copolymers to decrease the fabrication temperature necessary for melt electrowriting. In this study, melt viscosity and Tg values of the polymers, the polymer-drug mixtures and the polymer-drug-plasticizer mixtures were studied. Selected samples were used for MEW fabrication and evaluated regarding their printability and dissolution profile.