The current design protocol included a fair amount of manual post-processing and evaluation. Torsional favorability played a large role in the selection process, in part due to a lack of explicit consideration during the design. The Drugit client has since been augmented to include scoring for disfavored internal rotations. Less amenable to client incorporation is the hands-on refinement of the player designs by experienced medicinal chemists. These primarily represent removal of structural alerts or unnecessary functional groups or their replacement with the parent compound structure. Further investigation of tools and objectives to encourage players to perform such removal/replacements themselves is needed. Additionally, as RosettaLigand docking score, which is used internally to evaluate the quality of binding, is not strongly correlated with binding success, further improvement of binding evaluation in-client should increase the rate of player success.