Consequently, their conjugation to metal complexes appears as a rational choice for drug design as this type of modification can promote biocompatibility and increase water solubility. Carbohydrate-metal hybrids show promise in medicinal chemistry but also in catalysis . Apart the metal, its oxidation state and coordination mode , various structural adjustments were considered as the type of the carbohydrate and its substitution position , the presence and nature of the protecting groups .