In conclusion, we have successfully constructed a tandem catalytic process for the functionalization of AMFC by synthesis of AMFC-derived amides from alcohols via combination of goldcatalyzed oxidation reaction with acyl-CoA ligase-promoted amidation. These results illustrate the potential of biosourced AMFC as a platform molecule. The Au/CaO chemical catalyst achieved complete conversion of all tested aliphatic mono-and di-alcohols, ranging from C4 to C8, using atmospheric dioxygen as the sole oxidant. Moreover, this heterogeneous catalytic step was conducted under conditions compatible with subsequent enzymatic use, offering significant atom economy and reducing the process's associated hazards. In parallel, eight acyl-CoA ligases were screened against 12 mono-and di-carboxylic acid substrates. Overall, all the enzymes showed good activity and enabled the conversion of a broad range of carboxylic acids. One enzyme, TsACL, was revealed to be highly promiscuous and was retained for developing the tandem catalytic process. The hybrid process, which sequentially combines these two catalysts in a single pot was devised to yield the corresponding amide derivatives. Using AMFC as the nucleophilic amine, this one pot-two steps process achieved yields of up to 64 % in 24 h. One limitation of this process is the use of large excess of ATP, but this could be easily circumvented by setting up an ATP regeneration system. Another avenue for improvement is to implement a fully integrated process in a single step, ideally using catalyst compartmentalization techniques to obtain a multi-catalytic hybrid materials. This tandem heterogeneous enzymatic catalysis, performed under mild aqueous conditions, marks a significant advancement through the integration of gold nanoparticles and enzyme within a single reaction vessel. This innovative approach provides a groundbreaking method for the functionalization of the biosourced AMFC platform molecule.