Liquid chromatography (LC) is a powerful analytical and preparative technique, that has a strong presence within pharmaceutical sciences and other disciplines. While significant improvements have been made surrounding the hardware, methods, and column technology for LC, the overhead regarding solvent consumption and run time during method exploration is always desired to be further reduced . When utilized on a large scale, such as during high throughput experimentation and purification, factors surrounding solvent and instrument usage dramatically increase compared to traditional method screenings and fit for purpose separations .