For a typical 12-13 nm sized SPION, τB and τN are in the order of ~10 -5 s and ~10 -8 s respectively, therefore, the magnetic spin moment reversal or the Néel relaxation is the principal contributing factor for localized heat production in magnetic nanoparticle hyperthermia . In this specific system of nanorobots, the superparamagnetic nanoparticles are tightly bound to the silica surfaces. Consequently, the heat loss via Brownian relaxation is strictly restricted in this case. The mechanism of heat generation comes primarily from the intrinsic Néel relaxation as well as from the ac magnetic hysteresis losses, as the particle spins fail to follow the high frequency (~220 kHz) of the alternating magnetic field . In this case, the red fluorescence response primarily arises when the DNA components ooze out and bind to the PI following the rupture of the cell membrane. The mechanism of cell annihilation via magnetic nanoparticle hyperthermia is still debatable, and there are reports attributing hyperthermia induced cell death to both apoptosis (programmed cell death) and necrosis (unprogrammed cell death) . There are various factors, particularly, the concentration of nanoparticles, nature of ECM, local heating efficacy etc . which practically decides the nature of cell death triggered by magnetic nanoparticle hyperthermia. However, in this case, we hypothesize, that in the presence of a high frequency alternating magnetic field, the iron oxide nanoparticles adhering to the nanobots trigger sudden heat shocks or imparts highly localized thermal stress, creating sub-local damages in the cell membrane (leading to membrane rupture), which possibly manifests in a necrosis-induced cell death. We have successfully designed and developed SPIONs' functionalized nanorobots, a unique system, comprising of 10-12 nm-sized iron oxide nanoparticles firmly adhered to the surfaces of the 2.8-3.0 m long silica helices. The stable coating of iron oxide particles over the entire silica surfaces was successfully achieved using the microwave synthesizer. SPIONs-NR are reported to be highly stable against magnetic agglomeration, primarily because of the near zero remanence exhibited by the superparamagnetic particles covering their surfaces. The random arrangement of magnetic spins on the helical surface creates interesting dynamical properties of these functionalized nanorobots. The precession angle vs applied frequency analysis reveals that individual superparamagnetic nanoparticles adhering to the silica helix collectively impart dynamical properties which corresponds to a ferromagnetic-like behavior. Finally, these iron oxide functionalized robots prove to be a significant nano-vehicle, which are controllably maneuvered in the ECM at comparatively lower fields (<50 Gauss), for delivering magnetic hyperthermia-induced local heat at the single-cell resolution, possibly leading to cell death via necrosis. The chemistry of conjugating iron oxide particles with cancer drug molecules, particularly, doxorubicin, is well established. In future, SPIONs-NR can be functionalized with cancer drugs to bring about a synergistic approach of cell killing via magnetic hyperthermia induced localized heating.