We are also interested in exploring the internal degrees of freedom of the ligand. Performing random rotations of ligand rotatable bonds might be one way to explore the internal degrees of freedom. T4 lysozyme with n-propylbenzene might be suitable for such a test, as the crystal structure shows multiple binding modes due to rotations of the ligand's alkyl tail. Also, rings within a molecule can often be pseudosymmetric, thus necessitating sampling of each ring conformation. These ring flips can be similarly treated by rotating the internal bonds of the molecule.