A 360-exploration of protein targets (i.e. extending out to literature, structure, evolution, genetic variation, alternative splicing, pathways, interaction data, disease mechanisms etc) is beyond the scope of this report. However, since ADEV teams, by definition, will be intensely focused on their portfolio over some years it is not only important to develop a deep perspective on their target biology and pathology but they also need to be actively alerted to changes triggered by new data from any angle (that could bring good or bad news). From their UniProt links, both GtoPdb and ChEMBL provide a convenient gateway into the protein informatics universe. The minor problem with PubChem is that, on their side of the Atlantic, targets, including those in BioAssay, are indexed throughout the Entrez system according to the NCBI Reference Sequence Database (RefSeq). This uses separate identifiers but the European and US systems at least cross-point. Another important aspect is that UniProtKB is composed of two sections, the expert reviewed and curated UniProtKB/Swiss-Prot section and UniProtKB/TrEMBL where the records are compiled via automatic annotation and classification. This is more significant than most ADEV teams may realise especially since there are discrepancies in the human proteins counts between sources (see 'Last rolls of the yoyo: Assessing the human canonical protein count . As the Guide to Malaria Pharmacology team has found out, for ADEV teams working on tropical diseases, the lack of manual expert annotation on parasite protein drug targets becomes problematic (Jane Armstrong, personal communication). As an example, for the Plasmodium falciparum 3D7 reference proteome only 163 are Swiss-Prot reviewed while 5145 are still automated TrEMBL entries.