Diabetes and obesity are susceptible to COVID-19 disease , and are also essential factors in the transition to the worsening of COVID-19 condition . COVID-19 makes infected people susceptible to hyperglycemia; high blood sugar modulates immune and inflammatory responses . Obesity is related to the accumulation of macrophages in white adipose tissue (WAT), contributing to the development of insulin resistance. Intestinal flora induces the collection of lipopolysaccharide (LPS)-dependent macrophages in WAT, the damage to systemic glucose metabolism . Therefore, it is vital to study the pathological mechanism of the susceptibility and severity of COVID-19 in patients with diabetes and obesity caused by endotoxin (lipopolysaccharide) and LPS-dependent macrophage.