Ultimately, one of our long-term goals is to accurately predict binding thermodynamics, even when accompanied by protein conformational change. However, such predictions require that the representative states of the system be sampled with their correct populations. Thus, slow sidechain rearrangements can pose substantial problems for accurate predictions. By focusing on enhancing sidechain sampling in biomolecular simulations, our goal is to ultimately improve the accuracy of downstream applications used for prediction of binding modes and binding thermodynamics.