Overall, introducing a screening-guided warm start into the genetic algorithm-based framework COSMO-CAMD significantly enhances the efficiency, effectiveness, and robustness of the computer-aided molecular design process. The presented method is generic in nature and can be directly applied to all subsequent developments of the COSMO-CAMD framework and the genetic algorithm LEA3D. It can also be readily adapted to other genetic algorithm applications within the field of computer-aided molecular design.