for analyzing the data collected to date. The main applications have focused on understanding the biological activity of NPs, carrying out the systematic search for bioactive NPs with respect to a molecular target of interest, and guiding the chemical synthesis of NP analogs with simplified structures and improved activity. The NuBBEDB database has been expanded in collaboration with CAS (Chemical Abstracts Service). Currently, more than 54,000 substances are described with information on chemical, biological, and pharmacology data that can be explored in order to analyze their medicinal chemistry potential. Recent work on target predictions for compounds in the NuBBEDB led to the identification of chalcones with potential application for the treatment of Chagas disease .