Bemis and Murcko's scaffold represents the two-dimensional chemical structure of a molecule as a framework formed by the assembly of ring systems and the linker atoms that connect them. Scaffold analysis in chemical databases is widely employed as it facilitates the classification of compounds and the grouping of molecules with similar properties or the identification of scaffolds that can be added to existing molecules to improve their properties. The workflow in Figure facilitates the generation of a new row that includes the Bemis-Murcko scaffold derived from the input chemical database. After identifying scaffolds for BIOFACQUIM, which includes 605 distinct natural products, a total of 311 unique scaffolds were found. The three most frequent scaffolds were benzene (53 occurrences), flavone (25 occurrences), and 1,2-benzodioxole (ten occurrences).