Recently, the Martini 3 force field was extended to include parameters for carbohydrates, α -D-glucopyranosyl-(1→1)-α-D-glucopyranoside) . In this section we present a systematic approach to generate the coordinates of disaccharides and the parameters to use within the Martini We first describe the fully automated pipeline and resultant CG datasets for mannose and glucose-containing disaccharides (Figure ). The first step in the automated procedure involves generation of all the different anomeric conformations of α/β -D-glucopyranose and glycosidic bonds (α/β 1,1; 1,2; 1,3; 1,4; 1,6), resulting in a total of 20 different unique disaccharide molecules.