Comparing with Diff-Shape, ShapeMol and SQUID generate conformations with lower shape similarity under the same shape condition which might explain their less favourable docking scores. Pocket2Mol, under the control of binding pocket structures, produced molecules with slightly higher shape similarity than the uncontrolled MIDI model; however, it is significantly less than that of Diff-Shape models. The performance of DiffSBDD is similar to that of Pocket2Mol, albeit its docking score is slightly inferior than Pocket2Mol.