In line with the amount of data in ChEMBL per organism (Supplementary Table ), the most frequently tested variants were in human proteins (BRAF, IDHC, RPKS6B1, EGFR). Indeed, out of the variant annotated bioactivity data, 90.56% corresponded to Homo sapiens. Viral and bacterial variants were also represented, however with only 4.82% and 0.70% of the bioactivity data. The remaining bioactivity data corresponded to 13 non-human Eukaryotic organisms of interest in preclinical studies, such as Rattus norvegicus or Mus musculus, among others.