On the 17 iminopyrimidinone compounds reported by Stamford et al. the QSAR model achieves a Spearman Correlation Coefficient of ρ = 0.7 (p-value=0.004) compared to the reported IC50 values. This means that although we did not include compounds with an iminopyrimidinone scaffold in the training, the BACE1 activity prediction model shows a reasonable performance in the part of the chemical space we are interested in (i.e. compounds with iminopyrimidinone scaffold).