The acquisition of 1 H NMR data, HSQC, TOCSY, HSQC-TOCSY and HMBC for all samples processed, from the initial extract, in the case of a study on natural products, is strongly suggested. The same is valid for MS analysis in order to create a bridged analysis between both techniques in a complementary manner. Understanding that this is, perhaps, an unreasonable expectation due to the time (and costs) required to acquire each experiment, the use of NOAH supersequences are strongly suggested. This recommendation was highlighted by a recent publication proving that NOAH supersequences can be successfully used to collect data for COLMARm to achieve library matching. NUS, which was not detailed here, is also suggested whenever possible when there is enough sample for adequate sensitivity.