All Molecular docking experiments were achieved on CybertronPC CLX 13th Gen Intel(R) Core(TM) i9-13900KF @ 3.00 GHz comprising 24 computing cores. Schrödinger Release 2023-3: Glide software was used as the docking program . Crystal structures of CB1, CB2, GPR119, PAK1, and PPAR-γ were retrieved from the RCSB Protein Data Bank. CB1 [(PDB: 7V3Z), (PDB: 5U09), (PDB: The proteins were prepared and minimized using a protein preparation workflow tool on Schrӧdinger Protein Preparation Wizard . The external water molecules and ions were removed. Polar Hydrogens were added. Missing side chains were filled using Epic and PROPKA. Het states were generated at pH 7.4 (+/-2.0). Heavy atoms converged to RMSD 0.30Å. 3D structures of cannabinoids and hydrogenated cannabinoids were established in 2D sketcher which was then exported as an SDF file and imported and prepared using LigPrep, to form 3D conformers, including the various 3D chiral conformations. All structures underwent geometrical optimization using Release 2023-3: Jaguar software using density functional theory (DFT) calculation with B3LYP/6-31G as the basis set for the calculation to afford the minimized energy chemical structures. The structures were then docked using Release 2023-3: Glide software from Schrödinger.