The 2 example molecules 48:32 and 74:16 are plain looking molecules, with 48:32 almost reflective symmetric in the occupied Mpro region by Nirmatrelvir. The direct output only, without editing, of molecules from Ligand GA are presented and editing of molecules is expected in refinements of general Ligand GA output. 3 other molecules besides these 2 are also structurally described and several others mentioned. Information from the calculations are in the Supplementary Information.