In this work, the predicted rate constant is thought to be "accurate" when the deviation is less than 100%, "reasonable" when the deviation is about 300%, and "inaccurate" when the deviation is larger than 500%. Houston et al. showed that the calculated rate constants by the TST methods were within 330% of the accurate answers on a set of 39 test reactions. Therefore, the "reasonable" level is close to the accuracy of traditional TST methods.