Activity of antrafenine against SARS-CoV-2 helicase was predicted by Wu et al. (Supplementary Table ) using a homology model and the ICM 3.7.3 modelling software . Mevada et al. used Autodock Vina to screen drug candidates against SARS-CoV-2, including against the helicase and antrafenine was shown to be potentially active against the helicase and many other targets, including the viral spike protein . However, as no post-docking MD simulations were conducted on the lead molecules the results would need to be viewed with caution. Cozac et al. used machine learning and Autodock Vina calculations to predict antrafenine as an inhibitor of RdRp .