For the statistical analysis, peak intensity tables were uploaded to MetaboAnalyst 6.0 (web interface) , normalized by sum, log10 transformed and Pareto-scaled. Principal Component Analysis (PCA) was performed using MetaboAnalyst 6.0 while Analysis of Variance (ANOVA) with Tukey's honestly significant difference (HSD) post hoc test was computed in R (version 4.1.2). A p-value < 0.05 was considered as statistically significant in this study. Significant lipids in serum were subsequently subjected to Lipid Pathway Enrichment Analysis (LIPEA) .