In order to assess whether single-step speed-ups translate to multi-step retrosynthesis search, a full multi-step retrosynthesis search on 5,000 ChEMBL molecules was analyzed for each of the single-step models. We compared model performances with a small template-based model which is currently used as default in the AiZynthFinder framework. Carbon footprints are noted in grams and are mostly in agreement with search times.