The GDCCs have been shown to bind diverse guests varying in polarity, positively and negatively charged, as well as organic cations and anions . The latter has been shown for OA, where binding thermodynamics is sensitive to the concentration and type of anions present. Shifts in binding enthalpies and free energies of approximately 10 kcal/mol and 2 kcal/mol respectively have been observed and attributed to the competition between guests and anions leading to entropy-enthalpy trade-offs . In addition, experimental and computational simulation results show that de-wetting of GDCCs leads to increased guest affinity, because water cannot compete for the pocket .