The pH of the aqueous phase of bi-phasic mixture was selected according to the pKa of the compound being used. This was done to ensure that the entirety of solid drug substance would go into solution for the analysis of the bi-phasic mixture, to provide for the computation of the distribution coefficient. Typically, logD measurement experiments are performed at a specific pH of interest, such as physiological pH. In this study which aims to create a benchmark dataset for evaluating computational predictions, there wasn't a need to focus on a particular pH. We had the freedom to select any pH that would make the logD measurements easier and more accurate by ensuring adequate aqueous solubility. If any solid particles were to be found in either phase, it could hinder the chromatography analysis which may contribute to a significant error when computing logD.