Rapid and accurate phase analysis of pharmaceuticals is of great importance. In order to apply SerialRED to more beam-sensitive pharmaceuticals crystals, cryo-EM and low dose 3D ED data collection protocol, similar to those used for study protein crystals by MicroED were applied. Furthermore, we combined the widely available commercial software EPU-D (Thermo Fisher Scientific) for batch data collection with the program edtools for semi-automated data processing and clustering . When collecting data in batch mode, crystal locations are manually selected and added to a list. Tilt-series are then automatically collected from all positions on the list with a constant rotation range. The mechanical eucentric height near each pre-defined crystal position was automatically aligned before 3D ED data collection, to improve overall tilt range. Using this method, hundreds of datasets with large rotation ranges, typically greater than 80 degrees, can be collected and processed in only a few days. Furthermore, the accumulated electron dose of each dataset was less than 1 e -/Å 2 (~3.8 MGy).