The nature and surface curvature of the organic ligand shell strongly influences the thermodynamics of reactions at the surface of colloidal nanocrystals. From these measurements, it is evident that care must be taken to describe reactions at the surface of nanocrystals due to these complicated, inter-connected effects. Further studies into the nature of the ligand shell are certain to reveal more intricacies about these collective effects of the ligand shell, and effects such as those originating from faceted nanoparticles on these interactions are certain to add additional layers of complexity. Due to the high variability of parameters that can influence the thermodynamics of ligand exchanges, it is likely the reaction thermodynamics of individual samples of nanocrystals, even if they are somewhat similar, may vary significantly. However, these measurements have shown the robust ability of the modified Ising model to account for these interactions and to draw definitive conclusion, and such composition dependent models are certainly the key to describing the thermodynamics and structure of the organic ligand shell at the surface of colloidal nanocrystals.