CACHE will also be well-positioned to collaborate with other successful community initiatives in order to increase the impact of CACHE. For example, if CACHE includes a viral target among the challenges, then the CACHE predictions might input into community anti-viral development initiatives † . Predicted compounds that pose synthetic challenges can be turned into additional community challenges to design and predict the most efficient synthetic pathway for a given small molecule ‡ . Confirmed hits could also be used as starting points to develop new chemical probes § .