We have illustrated how we can utilize forward synthesis prediction in the CRKG for generating novel compounds with our proposed method. As a result of the interconnection of synthesizability and de novo design we can be more confident that the compounds generated are synthesizable, which is an essential criterion for de novo molecules to be useful. However, the synthesizability included in the prediction is, in this study, limited to one step which in general is not enough for ensuring that the products are synthesizable from the available building block molecules. One possible solution could be to perform the method in multiple steps, starting from a graph containing only building blocks and iteratively increasing the chemical reaction space.