Both 35399 and 4566 ID representative scaffolds predicted hundreds of molecular variants differentiated only by a few atoms, positions and/or rings. Detailed PyMol visualization of the gpGVHSV pre-fusion R4-TrD interface crossdocked to top-children DWBEL-conformers may be further explored at Supporting Materials / 600Children-gpGvhsv.pse. Top-children examples of the two representative scaffolds, predicted similar cross-dockings that might interfere with the interface between the amino terminal invariable α-helix of TrD (Figure , red) and the carboxy-terminal of the R4 linker (Figure , green).