In this process, we contrast simulation methods based on theoretical prior knowledge (e.g. seeding) with rare events simulation methods based on the introduction of a bias potential (e.g. metadynamics) and methods based on sampling nucleation trajectories in path space (e.g. forward flux sampling). This review on methods to simulate crystal nucleation, and we also note that significant progress was also made in recent years to simulate crystal growth from solution by combining MD simulations, Kinetic Monte Carlo, and enhanced sampling .