[A] Biologically relevant molecules containing a P(V) stereocenter; Cy = cyclohexyl [B] Classical and modern approaches to enantioenriched P(V) compounds; SPO = secondary phosphine oxide; CuAAC = copper catalyzed azide-alkyne cycloaddition; PdAAA = palladium catalyzed asymmetric allylic alkylation [C] A distinct catalytic two-phase strategy for the modular synthesis of enantioenriched P(V) compounds; [D] Complementary two-phase strategies developed by our own group (D1) and that of Jacobsen (D2), with the limitations of each method highlighted in red; [E] This work: an improved, second generation desymmetrization/derivatization strategy for the synthesis of enantioenriched P(V) compounds enabled by a new BIMP catalyst/thiazolidinone leaving group combination.