In a previous work, 11 we have investigated in detail the residence time of different solvents at morphologically-relevant faces of ibuprofen. The work of defect formation obtained here is reported as a function of the solvent residence time at the crystal-solution interface computed in Ref. Assessing Fig. , a prominent correlation between the residence time of a solvent molecule at the crystal surface and the work required to form a surface vacancy can be noted, particularly for the {002} and {011} crystal facets. This relationship indicates that the mechanism of detachment for these surfaces is strongly affected by desolvation. We note that, for these two faces of ibuprofen the relative dissolution rate was recently measured showing the two faces dissolve with rates of the same order of magnitude. This is consistent with our calculations that identify very similar works of defect formation for these two facets across all solvents (see 6A).