There are 13 unique drugs currently approved by the US FDA for the treatment of these rare diseases. Three of these compounds have multiple approved formulations, as well. One example, the drug riluzole has three different formulations approved. The first being an oral tablet, there is also an oral film, and a thickened suspension available for patients dealing with muscle tone and swallowing issues. One of the approved drugs for the treatment of ALS, Relyvrio, has been recently discontinued. Amylyx Pharmaceuticals has started the process with the US FDA of discontinuing authorizations for Relyvrio and removing it from the market. While Relyvrio is generally safe and well tolerated, it unfortunately failed to meet primary and secondary endpoints in a Phase III clinical trial (NCT05021536). 446