Several modifications are made to Field-Effect Transistors (FETs) to build the platform for further advancements in biosensors - . Ion-sensitive (IS) FET is the simplest structure for sensing applications - . There are several ISFET architectures - used to tune the sensing parameters but using them for biosensing is limited by the Debye length - . The idea of sensing proteins using FETs was proposed by P. Bergveld , , but it was discarded as the protein charges reside over the Debye length which are balanced by the counterions in the electrolyte making the sensor insensitive to the immobilized proteins. However, amino acids (AAs) and oligopeptides can be sensed due to their short length keeping the Debye screening within acceptable limits of ionic concentration - .