Mechanochemistry, i.e. chemical reactions induced and/or sustained through grinding, milling, shearing or other types of mechanical agitation, has emerged as a popular and versatile method for synthesizing molecules and materials in the absence of bulk solvents. The ability to circumvent the need for bulk solvents, while providing access to chemical reactions that are fast, proceed at room temperature, and can provide access to molecules and materials challenging to obtain through other means, makes mechanochemistry a highly attractive, 'greener' alternative to more conventional solvent-based synthesis. The scope of possible reactions by mechanochemical activation is widespread, with recent reviews and reports outlining mechanochemical approaches to organic, 2,3 inorganic, 4,5 organometallic, supramolecular, and coordination chemistry, as well as a range of advanced material targets such as metal-organic frameworks (MOFs), nanomaterials, and more. Mechanochemical transformations open the door to new synthetic opportunities such as the formation of unusual products, trapping of typically unstable intermediates, and the enhanced selectivity of products while also serving as an important tool for reducing reaction times. Many details of mechanochemical reactions remain poorly understood, with attempts to elucidate the underlying physicochemical process often involving extensive and systematic investigations of temperature and pressure, including real-time approaches, as well as screening of milling frequency, sample-to-volume ratio, ball diameter, material of the milling assembly, presence, and properties of liquid and/or polymer additives, and other parameters. Real-time monitoring of reactions by thermography, powder X-ray diffraction (PXRD), Raman spectroscopy, and different combinations of these have shown great progress in our ability to monitor reactions without the need to disrupt the reaction or dissolve the products for subsequent analyses. Nevertheless, in situ mechanochemistry monitoring approaches are still in their infancy, and face numerous challenges. One of these is difficulty obtaining reliable data when measuring over a limited and inhomogeneous sampling area. This can lead to low quality data that is difficult to interpret. The majority of current monitoring methods are surface measurements or require high-cost specialized apparatus. We are seeking to develop a monitoring method, through time domain magnetic resonance, that is compatible with the milling container employed with a mechanical shaker. This will permit simple measurement of the milling container and its contents when inserted into a benchtop MR instrument. The result would be a whole sample bulk measurement, where the sample is undisturbed in the milling container. It will thus be well suited to time resolving the progress of a mechanochemistry reaction in the laboratory.