We find that for 5 out of 6 molecules we simulated, AM1-BCC ELF10 reduce variability in AHFE and both partial charge variability metrics (Table ). For all 6 molecules, we find the OpenEye AM1-BCC ELF10 partial charges reduce the AHFE variability and the maximal partial charge di erence. For 5 of the 6 molecules, we find that OpenEye AM1-BCC ELF10 partial charges reduce the maximal q bond di erence.