Despite advancements in our understanding, significant knowledge gaps remain regarding the precise roles of chemical transport mechanisms in the pathogenesis of integumentary diseases. For instance, the impact of microenvironmental changes on molecular transport and immune cell behavior in chronic conditions needs further exploration . Additionally, the integration of transport phenomena with advanced therapeutic modalities, such as nanotechnology, remains under-researched and presents opportunities for enhanced therapeutic outcomes . The exact molecular mechanisms linking inflammatory mediators to biomechanical changes in the skin are not fully elucidated . There is also a need for more comprehensive models integrating biochemical, biophysical, and biomechanical data to predict disease progression and optimize treatment strategies. Further research is needed to develop more sophisticated models to simulate the complex transport processes within the skin, considering both diffusion and convection. More work is needed to investigate the interplay between species transport and the biomechanical properties of the skin, particularly in the context of wound healing and aging. The transport and transformation of chemical species within the integumentary system are fundamental processes that play crucial roles in maintaining its normal function. Disruptions in these processes can lead to the development of various skin diseases. Understanding the intricate interplay between transport mechanisms, chemical reactions, and biomechanical properties of the skin is essential for developing effective therapies and preventing skin disorders.