Figure shows that from zero to twenty minutes, both samples exhibit an accelerated release, reaching 38.28% for H9-EN and 55.81% for H5. Subsequently, H5 tends to stabilize at 60 minutes with a value of 57.22%. At the same time, H9-EN presents a controlled release up to 24 h, improving bioavailability, which may be mediated by pore size, pore volume, and the interaction between molecules. Three kinetic models were fitted from 0.33 h to 26 h for H9-EN, with R 2 values shown in Table .