Recently, a proposed change in EU law has raised concerns about a potential ban on a broad range of polyfluorinated alkyl substances (PFAS), including many CF3-containing molecules and reagents. While legislation is yet to be finalized, exceptions are expected for final pharmaceutical and agrochemical active ingredients. However, the ban could still impact their synthesis if synthetic intermediates, the required bespoke reagents or other CF3-containing sources were to be prohibited. Therefore, it becomes crucial to develop methods for synthesizing these moieties, at the late stage of a synthesis, from simple, non-fluorinated organic molecules, ideally utilizing cheap and widely available alkali fluoride sources for which no restrictions are foreseen. Such an approach would not only comply with the proposed EU law but also minimize or eliminate the need for perfluorinated materials in synthesizing most of the currently used fluoroalkylating reagents.