Sixteen drug molecules were selected for the SAMPL9 logPtol/w challenge. Each of the sixteen molecules fall within the parameters set by the Rule of 5 with a spread of experimentally determined logPo/w from -1.37 for epinephrine (6) to 4.92 for amitriptyline (3). These molecules hit a broad array of biological targets. As such, they have an extensive range of effects from anthelmintic properties in albendazole (1) to antibiotic properties in nalidixic acid (11) and sulfamethazine (15) to antidepressant properties in amitriptyline (3), imipramine (9), and trazodone (16). Structurally, this set of molecules have a wide range of expected polarities from highly polar epinephrine (6) to non-polar amitriptyline (3). In addition, there is a wide range of flexibility within the set, from fairly rigid molecules with only a few likely conformers in nalidixic acid (11) and paracetamol (12) to highly flexible systems with many energetically similar conformers in glyburide (8) and trazodone (16).