Only one of the CACHE participants explicitly included the visual inspection and subjective judgment of medicinal chemists as a final step in their selection strategy (WF1448). This step is common practice in virtual screening and should be better tracked in the future. Indeed, in its current set-up, CACHE evaluates not only computational methods but also the intuition and expertise of humans running these tools. The most seasoned computational chemist will be hard pressed to subjectively select hits out of a failed computational workflow. We would therefore argue that experimentally confirmed hits can only reflect successful computational workflows. Nevertheless, there would be some merit in requesting a more detailed description of human intervention from CACHE participants, including asking them to provide "computer-only" selections in addition to their final, human-selected sets (if any), at the risk of spending resources on testing compounds that do not pass the subjective evaluation of experts.