Compound 2. To a solution of 1 (0.96 g, 2.93 mmol) in THF (20 mL) and H2O (8 mL) was added LiOH (1.6 g). The yellow solution was stirred at room temperature overnight (4 hours are generally enough). The THF was then removed via rotary evaporator and concentrated HCl was added to the solution to initiate precipitation of the product. After cooling with ice for 1 h the precipitate was collected by filtration and washed with 3 M HCl (20 mL). Compound 2 was then collected by dissolution in MeOH and subsequent evaporation of the solvent, yielding the pure compound as an off-white powder (556 mg, 2.05 mmol, 70%). The NMR data matched that reported previously. 1 H NMR (400 MHz, MeOD) δ 7.95 (m, 1H), 7.85 (m, 1H), 7.12 JH-H = 9.1 Hz, 1H), 3.82 (d, J = 2.0 Hz, 4H). and triethylamine (0.08 mL, 0.57 mmol) were dissolved in a separate round-bottom flask in dry toluene (20 mL). Both solutions were added simultaneously over 5 min to a third roundbottom flask containing dry toluene (40 mL) cooled to 0 °C by means of an ice bath. The reaction mixture was allowed to warm to 25 °C under stirring for 16 h (however, reaction times as short as 1 h were found to be sufficient). The next day the solvent was removed via rotary evaporator and the crude was purified by automated silica column chromatography (dry loading after dissolution in DCM/MeOH; gradient 0-10% MeOH:DCM) yielding 4 as a yellowish oil (51.5 mg, 0.10 mmol, 25%). The NMR data matched that reported previously. 1 H NMR (400 MHz, CDCl3) δ 7.82 (dd, 3 JH-H = 2.6, 8.9 Hz, 1H), 7.77 JH-H = 2.6 Hz, 1H), 7.00 JH-H = 8.9 Hz, 1H), 5.63 JH-H = 15.0 Hz, 1H), 5.47 .