The exception is for compounds containing 10 rings, in which case the median number of ring formations suggested is the same for model trained on both datasets, however the number of suggestions exhibits a wider range. The 'Ring Breaker' model trained on the Reaxys dataset exhibits a wider range of templates predicted in the top 50 predictions than that trained on the USPTO dataset. However, the median number of ring formation is the same. c) The 'Ring Breaker' models predict more ring formations in the top 50 predictions as the number of rings in the substrate increases, as one would expect. The Reaxys model consistently predicts more ring formations in the top 50 predictions, than the USPTO model. An exception is observed for substrates containing 10 rings, whereby the median values are the same, but the number of predictions by USPTO model exhibits a wider range.