Coronaviruses are positive single-stranded RNA viruses, and are classified into four genera: 𝛼, 𝛽, 𝛾 and 𝛿. They infect a wide range of hosts, including birds, pigs, and humans. Although most family members produce mild respiratory effects in humans, new members have recently appeared that produce serious illness in affected individuals. We can mention as previous variants to the one that has been studied here, 229E, NL63, OC43 and HKU1, which cause symptoms of the common cold, and two more problematic, such as SARS-CoV-1 and MERS-CoV. SARS-CoV-1 was identified as the pathogen responsible for an outbreak of severe acute respiratory syndrome (SARS) in Guangdong Province, China, in 2002, and ten years later MERS-CoV was identified in the sputum of a patient who was retrospectively diagnosed with Middle East Respiratory Syndrome (MERS) in Jordan. Both pathogens produced an epidemic that spread to several countries due to international travel by infected people, epidemics that ended about a year after each outbreak after taking strict infection control measures. SARS-CoV-2 was first reported in Wuhan, Hubei Province, China, in December 2019. Severe acute respiratory syndrome caused by this virus, whose symptoms include respiratory illness and pneumonia 6 was named COVID-19, and the rapid spread of SARS-CoV-2 around the world led the World Health Organization to declare the pandemic on March 11th, 2020. As of June the 21th, 2022, there have been 536590224 confirmed cases and 6316655 deaths from COVID-19. 7 Humans are infected commonly and throughout the globe with seasonal coronaviruses, which usually cause a respiratory disease with mild symptoms. Hence, they have been never treated as an important public health threat, and development of a specific anti-viral treatment has not been considered a priority. Consequently, when SARS-CoV-2 emerged, there were no specific antiviral treatments for COVID-19.