For the log P and pK a challenge and the log D evaluation, we provide reference calculations using ChemAxon's Chemicalize , a commercially available empirical toolkit, as a point of comparison. These include REF# in the method name in all of the figures so that they are easily recognized as non-blind reference calculations. The analysis is presented with and without the inclusion of reference and/or null calculations in the SAMPL7 GitHub repository. The figures and statistics tables pertaining to the log P and pK a challenges and the log D evaluation in this manuscript include reference calculations.