As expected, the most efficient network layouts like the MST Network and the Star Network form disconnected graphs if even one edge is removed. For the MST Network case, it is hard to predict how many Components would be lost in a final ranking, as the loss highly depends on where in the structure the Transformation fails. The Star Network will lose as many molecules as failing edges (a 10% loss of edges, leads to 10% loss of molecules in the final ranking). As a practical note, a good transformation score function is one under which higher network cost directly correlates with more edge failures in the network. This meaning of cost has not been considered in this toy system.