A major factor affecting the performance of GLST is the number of cubature nodes to handle, which depends on the target accuracy and the distance between cells under consideration. For faraway cells, the number ranges from hundreds to thousands, while it rapidly increases as the distance between cells decreases (Fig. ). Thus, cells in the vicinity of the cell under consideration, either in non-periodic or wraparound relation, will involve the greatest number of cubature nodes. Similar to the PBC box repeat, using the relative instead of absolute error in force to determine the non-periodic and wrap-around cubatures will greatly reduce the number of cubature nodes. If accurate energy calculation is needed occasionally during the simulation, a separate GLST cubature for energy calculation may be prepared before the simulation and used when an energy call is made. Comparison with other methods such as PME and FMM, and implementation into working simulation engines, are subjects of future studies.