General procedure C. The corresponding diazepane (1 eq) was dissolved in DMF with a final concentration of 50 mM. Subsequently, the corresponding 2-chloro-heteroarene (1.2 eq) and K2CO3 (2.5 eq) were added under continuous stirring. The reaction was stirred for 2-10 days at 60 °C, until monitoring by TLC indicated total consumption of diazepane. Subsequently, the solvent was removed under reduced pressure, the residue was dissolved in DCM (15 mL) and washed with saturated NaHCO3 solution (aq., 10 mL) and brine (10 mL), respectively. The organic layer was dried over Na2SO4, filtered and the solvent was removed under reduced pressure.