We have used graph neural networks using the GrASP web server to forecast this site is druggable . In Figure , the druggable site is displayed. This indicates that the druggable and binding sites are yellow and green. Understanding the surface properties of the clusterin is crucial in validating the clusterin-aptamer docking results. Vfold2D was utilized to estimate the secondary structure of aptamers . Aptamer 2D is vital in defining the three-dimensional aptamer shape and provides information on base pair interactions (hydrogen bonds). A popular method for representing the secondary structure of nucleic acids, including aptamers, is dot and bracket notation, Figure . Several symbols, such as dots and brackets, are used to denote paired and unpaired bases in this notation. In this notation, paired bases in a stem are represented by parenthesis( ) and unpaired by dots (.). A pairing begins with an opening parenthesis, "(," and ends with a closing parenthesis, ")." The dot-bracket notation is shown in Table , and the 2D image is shown in Figure .