The non-covalent supramolecular affinities (such as hydrogen bonding, hydrophobic interaction, π-π stacking and van der Waals interactions) between polymers and drugs play a very important role in overall organization and colloidal stability of such assemblies. The efficient and stable encapsulation of cargo into the micelles is not only governed by cargo polymer interaction, but certain innate properties of cargo like chemical composition, rigidity, conformation, molecular weight (Table ) and/or most importantly interfacial structure between cargo and polymer also play a very important role. It is becoming more evident that the ultra-high drug loading reported for the majority of the tested drugs with POx/POzi based amphiphiles is partly because of hydrophilic pMeOx . The A-pPrOzi-A/curcumin and A-pBuOx-A/paclitaxel have been investigated thoroughly in this regard. Previously, investigating the ultra-high curcumin loaded A-pPrOzi-A formulation with solid state NMR spectroscopy , Pöppler et al.