For analyzing distillers grains co-products, a supported-liquid extraction method modified from the AOAC method was compared to the liquidliquid extraction used in this study. The modified AOAC method used the Chem Elut S column with prepacked synthetic material instead of diatomaceous earth, and MTBE was used as elution solvent instead of methylene chloride. Although MTBE is a much lighter solvent, it still enabled the elution by gravity flow at a reasonable speed. The extraction yield of EC obtained from supported-liquid extraction as calculated using the peak intensity of EC-d5 was lower but within 6% of that obtained from traditional liquid-liquid extraction. The critical step when using the supported-liquid extraction with samples such as Vers.20020601 WDGS and DDGS that contained fine particles in the aqueous extract would be sample clarification. Without prior removal of the particulates in the aqueous extract either by high speed centrifugation (>15000 g) or filtration, this column or the Chem Elut column recommended in AOAC method would quickly become clogged. Repeatability tests are needed to establish a standard protocol of the modified AOAC method for distillers grains coproducts.