Milling should also be evaluated from more than just analyte recovery aspects. Environmental and economic considerations are part of a broader picture of the practical challenges encountered in laboratory operations. Personal conversations by the corresponding author with laboratory directors from Washington State and California revealed significant operational burdens related to milling, including the extensive staff time dedicated to milling and cleaning tasks, which can account for approximately 50% of staff efforts. This not only leads to increased salary expenses but also generates significant cleaning waste. The tendency of some laboratories to avoid milling to conserve resources further underscores the operational and financial challenges faced. The often-used cheap coffee-grinder styled mills have a short lifetime, and the replacement costs add up for the fleet of mills in operation. The potential adoption of single-use milling containers emerges as a means to mitigate cleaning requirements, thereby saving time and reducing operational costs. However, this approach may result in increased waste and environmental impacts, contingent on the materials used and disposal practices. This juxtaposition of convenience against sustainability necessitates a thorough analysis that considers environmental impacts, cost-effectiveness, and operational efficiency. Such an analysis is critical for informed decision-making regarding milling container selection, aimed at optimizing cannabinoid analysis outcomes, operational efficiency, and environmental sustainability. The research contributes important insights into this decision-making process, underlining that the choice of milling parameters and container types significantly impacts the analytical results, operational efficiency, and environmental footprint.