HME was carried out on a ZE 9 HMI extruder (Three-Tec GmbH, Seon, Switzerland). The screw speed was set to 20 or 30 rpm for the whole extrusion process. Detailed information can be found in the Supporting Information (Table -S8). The total amount of sample was around 5 g, which did not allow the use of continuous feeding during the extrusion process.