To summarize, a convergent total synthesis of 2 has been accomplished by leveraging hidden symmetry of the seemingly distinct eastern and western halves of the molecule. A unique (and perhaps general) strategy for the synthesis of b-branched amino acids that enlists simple N-H aziridine building blocks in either stereo-and regioselective C-C (western fragment) or N-C (eastern fragment) ring opening events enabled this plan. The strategic use of a furan and aryl bromide to shield the most sensitive parts of the final natural product are also noteworthy tactics. The modular approach to 2 should enable an extensive study of the SAR of this fascinating family of antibiotics.