In Synthesis Planning, complete routes from the building blocks to the target molecule are returned. Synthesizability scoring provides numeric or categorical scores for how easy a molecule can be made. In Biased Molecular Generation, molecules are constructed from fragments derived from sets of successfully synthesized molecules. In Reaction-Driven Molecule Generation, molecules are constructed as they would be made in the lab, using recursive application of virtual reaction rules and building blocks in the forward direction. Fig. shows how these methods can be incorporated into DND workflows. We will now discuss the methods in more detail.