Step 2: Charge 2-MeTHF (2562 kg, 8.54 X) to a suitable inert reaction vessel and test to ensure water content is not more than 0.5%, followed by charge MR84907 (300 kg, 1.00 X, 1.00 equiv.). The resulting mixture is stirred at 10-30°C to provide a homogeneous solution and to the vessel is then charged anhydrous K3PO4 (363 kg, 1.21 X, 3.00 equiv.) and regulatory starting material MR84908 (99.0 kg, 0.33 X, 1.50 equiv.). The mixture is degassed and to the vessel is then charged (R)-BINAP (10.5 kg, 0.035 X, 0.030 equiv.) and Pd2(dba)3 (7.80 kg, 0.026 X, 0.015 equiv.). The reaction mass is heated to a temperature range of 77-80°C for not less than 20 hours and subsequently sampled for HPLC analysis to determine reaction completeness. The reaction is deemed to be complete when the level of residual MR84907 relative to product MR84909 is not more than 3.0% a/a. Upon achieving a conforming IPC result the mixture is cooled to 15-38°C and to the vessel is then charged purified water (1500 kg, 5.00 X). The aqueous phase is then separated and discarded. The organic phase is washed with aqueous NaCl (5.21 wt%, 633 kg, 2.11 X). The aqueous phase is separated and discarded and the organic process stream containing MR84909 is telescoped into the next process operation.