Smal l Molecules Interacting with RNA (SMIRNAs) have the potential to be broadly deployed to affect biology, to help study the biological roles of RNA, and to develop novel RNA-targeted therapeutics. The most common way to target RNA is via its sequence by using antisense oligonucleotides. RNA, however, folds into 3dimensional structures that often affect its biology, including causation of disease. Thus, SMIRNAs can serve as an alternative approach to target RNA, affording distinct target sites and potential advantages.