The newly focused libraries developed in this study contain a complete description of the methodology used to construct them and represent a notable addition to the commercial epigenetic-focused libraries currently available. In agreement with open science and its symbiosis with artificial intelligence and other computational applications , all fragment libraries generated in this work are freely available and can be used for further virtual and experimental screening for epigenetic drug discovery, emphasizing DNMT1. The diverse than those from the LigBuilder ones and exhibit better profiles of QED and SAscore. However, both libraries had similar results with docking scores and had predicted actives with the classification model. Since