We built inclusion complexes where guest 2 is encapsulated within cage 1 in different stoichiometries: i.e., 2 ⇢ 1 and 2 2 ⇢ 1, where respectively one or two 2 amide guests are encapsulated inside cage 1. In particular, the AA model for the 2 2 ⇢ 1 complex was built starting form the available experimental crystal structure for this complex, 10 while that for the 2 ⇢ 1 was obtained by deletion of one of the 2 guests. Aromatic amides, like 2, exist mainly in a trans-planar conformation in solution. However, experimental evidences demonstrated that 2 may adopt a cis-twisted conformation within the T d symmetric cavity (forming a pseudo-S 4 symmetric dimer) in cage 1. In particular, X-ray and NMR measurements showed signals corresponding to a cis:trans 1:1 2 dimer in the 2 2 ⇢ 1 complex, and to a cis-twisted conformation in the 2 • 3 ⇢ 1 complex.