Historically such reagents have been employed for carbon-based nucleophiles; in this case the use of these conditions led to increased reactivity with considerable suppression of two major reaction byproducts (𝛽-elimination and intramolecular cyclization of the N-Boc group to an oxazolidinone). With the key bromo arene installed with the proper stereochemistry, Boc-deprotection of 21 and subsequent coupling with 14 using HATU afforded 22 (59% yield). Reduction of the nitro group of compound 22 to the primary amine was completed using Fe and NH4Cl. Gratifyingly, the Larock cyclization of the corresponding crude aniline was successful using similar conditions to the first macrocyclization reaction to give 23 as a single atropisomer in 67% isolated yield over two steps.