General Considerations. All commercially available reagents were used without further purification. All reactions, unless otherwise indicated, were carried out in flame-dried flasks under argon atmosphere with anhydrous solvents. FTIR spectra were recorded using a Perkin-Elmer Spectrum One FT-IR or Bruker ALPHA FTIR-ATR. 1 H and C NMR spectra were recorded on Bruker 400 or 500 MHz or Varian 400 or 500 MHz spectrometers. Chemical shifts are reported in ppm using the residual of deuterated solvents as an internal standard. Thin layer chromatography visualization was performed by UV or by development using ninhydrin, para-anisaldehyde, vanillin, ceric ammonium molybdate, or KMnO4. Chromatography was performed on silica gel 60 (230-40 mesh) or using the Biotage One Isolera with ZIP cartridges. High resolution mass spectrometry was performed by ESI on a Bruker Maxis Impact API QqTOF or by ESI or APCI on a ThermoFisher Exactive Plus Orbitrap-API at McGill University. Prior to biological testing, reverse-phase HPLC was used to verify the purity of compounds on an Agilent 1100 series instrument, equipped with VWD-detector, using a C18 reverse column (Agilent, Eclipse -C18 150 mm Å~ 4.6 mm, 5 μm) with UV detection at 254 nm. All tested compounds were at least 95% pure. All compounds were stored at -20°C.