There are some works that regard the importance of such molecules in reaction systems. Welsch et al. and Schneider et al. describe the advantage of designing drug compounds from certain molecular frameworks, which they describe as privileged scaffolds. The molecular frameworks are formed of geometries, which are suitable to be coupled with side chains. The final product may then bind to target proteins. The suitability of a scaffold is determined in two ways: it is either based on the promiscuity of the most observed scaffolds, which is expressed as Shannon entropy, or it is based on the maximal information content. These scaffolds are stressed for the development of biomedical applications. In a very different approach, Aden et al., inspired by the petrochemical industry, focus their work on bio-based building blocks for future supply chains. They consider market-specific selection criteria as well as structural properties of the molecules. More recently Serrano-Ruiz et al. combined flow-chemistry with bio-derived platform molecules. Also in their work market-specific criteria for the selection of bio-based platform molecules were named; e.g. based on availability of commercial technology for their production and for their potential to contribute to both fuels and chemical production. Szymkuć et al. identify hub molecules in reaction nertworks by a popularity function. This means that molecules were identified as hubs due to the number of links in the network and then these molecules were favoured during synthesis planning . All aforementioned approaches have the same aim: they desire general descriptions of useful molecules for broad sets of applications. With the goal to extend the application sets to the whole chemical supply chain, we find the method of Szymkuć et al. well suited, because it operates on whole network structures.