Penalized logP is composed of a combination of the three physicochemical properties of logP, SA score, and RingPenalty, and multi-property optimization was relatively successful in VGAE-MCTS. This suggests that VGAE-MCTS can be used to search for molecules considering multiple physicochemical properties. VGAE-MCTS can be expected to be used in practical drug discovery process where multiple conditions are optimized.