We note that the four-and five-component materials achieve the highest yields of oxygenates at higher temperatures (400 ºC) compared to the the three-component systems (300ºC) -see Fig. . The SG rule on the reaction temperature derived based on the three-component materials data set is thus not transferable to the four-component ones. Finally, we applied the SGD approach to the four-and fivecomponent HTE data (746 data points, Fig. and) using the same candidate descriptive parameters used for the previous SGD analysis of three-component materials. The identified SG presenting the highest m /no (0.355) contains 18 data points, i.e., ca. 2.4 % of the data set (black points in Fig. and). The selected data points correspond to one four-component material with tellurium as V Ç element as well as different compositions of five-component materials with V Ç = Te and V ^= Mo, Nb. The rules describing this SG (Fig. ) constraint the values of three parameters: I ≥ 360 ℃, L ã+1 ≤ 1.001 Å, and VH < -1.593 eV, (Fig. , and F, respectively). The comparison of these SG rules with that for the SG obtained with the three-component materials data set (Fig. ) highlights the higher temperatures needed for the four-and five-component materials to achieve outstanding performance. Moreover, different composition-dependent parameters (L ã+1 and VH) are required to describe this SG compared to the case of three-component materials (J K and VY), even though the electronegativity and the electron affinity are related by VY =