To some extent, the widespread use of ab initio thermodynamics to computationally determine the surface structures exposed in given (reaction) environments also belongs to this thinking. In a divide and conquer approach, 3 a classic multiscale modeling ansatz to tackle a possible operando evolution would be to employ this technique to identify the thermodynamically most stable surface termination, and then use this termination as the basis for a subsequently developed microkinetic model for the given reaction (either full fledged to gain mechanistic understanding or reductionist to conduct a high-throughput virtual screening ). The identified termination can indeed differ largely in structure and composition from any bulk-truncated one of the nominal material. Yet, once determined, this termination is typically modeled as static and the elementary processes considered in the microkinetic model only concern the surface reaction intermediates. Notwithstanding, that this divide and conquer ansatz is state-of-the-art is arguably less due to compelling experimental evidence for such a separation of time scales and a concomitant sufficient persistence of active site motifs on the evolving surface. It also arises from limitations in present-day technical modeling capabilities. Including an elementary process into a microkinetic model is a twofold challenge. First, one needs to identify the actual process itself, i.e. realize that the atomistic process could potentially exist and play a role.