Furthermore, the reported high-field NMR-based experimental strategy is applicable to materials with natural abundance 13 C nuclei, probing the chemical nature and structural organization of organic-inorganic hybrid materials and amorphous biomaterials of tunable composition and with varying nano-size domains. Correspondingly, 13 C spin-lattice relaxation rates can delineate organic nanoparticle-based assembly processes leading to the formation of solid coatings and semi-solid materials as well as the incorporation of inorganic structural moieties, paramagnetic defects, and open porous frameworks with a wide range of atomic and molecular mobility.