Apart from the theoretical inaccuracies (e.g. implicit water solvation), the prime weakness of SQM methods is their inability to estimate correctly the entropic contributions to the free energy upon ligand binding and to a lesser degree the ∆H. In this pilot study, we investigated the impact of explicitly calculated deformation energy on P-L scoring, which is an indispensable component of ∆H. In contrast with the theory, we found out that it offers no benefit in VS. Moreover, we demonstrated that a rough approximation of ∆H (coined ∆H*) from the docking poses achieves the same results. To our surprise, explicit calculation of ligand conformational entropy and inclusion to the P-L score had a detrimental effect on the performance of VS in 3 out of 5 datasets. The inclusion of both terms in the equation entailed thorough conformational sampling and thus extra computational burden, which we deemed unnecessary and without any practical benefit. As such, we concluded that the PM6/COSMO interaction free energy term is sufficient for scoring in VS.