In this work, we introduced the Python package cg_openmm which facilitates coarsegrained modeling and thermodynamic analysis of potential foldamer molecules, and analyze_foldamers, a companion Python package which performs structural analysis, in-cluding determination of native structure from RMSD clustering and calculation of bonded parameter distributions. a coarse-grained model, temperature replica exchange molecular dynamics simulations are performed using OpenMM, and MBAR reweighting is applied to the decorrelated replica energies to accurately calculate heat capacity, native contact fraction expectation, and free energy of folding as functions of temperature. Heat capacity and native contacts curves can then be analyzed to study the stability and cooperativity of a potential foldamer system.