Table : Breakdown of a ring formation specific dataset obtained from the USPTO and Reaxys datasets by considering all reactions in which there is a ring change greater than one between products and reactants. Compared to the entirety of each respective dataset, the percentage of reactions corresponding to ring formations is estimated to be 4.5 % and 5.8 % respectively, and the percentage of corresponding templates even lower. This shows that ring-forming reactions could be poorly represented considering the whole dataset and could fall within the noise, considering 12 % of the reactions in patents correspond to protections and deprotections. The numbers shown are after filtering for templates occurring a minimum of 3 times and compared to all templates and reactions obtained from the dataset.