Specifically, in the main text, all the correlation plots characterize the relationship between one metric and the experimental data. Therefore, in each of the 500 bootstrap iterations we performed, for each variant, we drew five bootstrap samples for value of the metric from the set of five different wild-type models, and five bootstrap samples for the experimental reference from normal distributions centered at the experimental values. From each of these 500 bootstrap iterations, we calculated one Kendall's tau correlation coefficient by correlating the sample mean of the two variables. Lastly, we calculated the standard deviation of these 500 values and reported it as the uncertainty of the correlation coefficient.