• If only significantly interacting structures are considered (that is, if extremely weak interactions derived from the SARS-ACE2 crystal structure are removed from the investigated sample) then the average of all calculated noncovalent interaction energies and sum of average energies for interactions 1-4 are also larger in SARS-CoV than in 2019-nCoV (see scenarios V and VI in Table ). This indicates that earlier predictions (suggesting the opposite) are potentially biased towards crystal structure geometries -which might indeed be unrepresentative of bound structures in physiological conditions.