Next, the generality of ATA reagents was evaluated using 4-bromo-pyrazole as the nucleophile (Table ). A library of ATAs with various substituents displaying different electronic effects was first tested under the relatively mild reaction condition 1. It was found that electron-neutral (52), electron-rich (53-55), and electron-poor (56-58) ATA reagents all provided the desired products in moderate to good yields. Additionally, the position of the substituents did not significantly affect the reaction yields (59-60). Furthermore, ATAs with heteroaryl groups, such as benzofuran and thiophene, were also found to be compatible (61-62). However, ATAs containing coordinating pyridine group (63) and strongly electron-withdrawing trifluoromethyl group (64) failed to produce any products under reaction condition 1. Thus, we applied the more stringent reaction condition 2 to these challenging ATAs. To our delight, the desired products were obtained in good yields (63-64). Unfortunately, the aliphatic ATA reagent did not produce any desired products under either set of standard reaction condition (65) (see Figure and Tables in Supporting Information for optimization details). In addition, we used morphine to further test the generality of ATAs, finding that both aromatic and heteroaromatic ATAs were effective in the reaction (66-71).