This symmetry-aware grid exploration divides the time required by the average number symmetry images -this module will be referred to as "symmetry" in Table . By combining both the "blocking" of the high energy grid points and the "symmetry" based calculation of the interaction energies, we built a "fast" version of the grid calculation algorithm that can compete with our previously developed rapid surface sampling method (RAESS). We will refer to this new sampling technique as the GrAED algorithm in the following text.