In this work, we have shown an accurate control of the acidity by means of electrochemically generated acid in 150 μm regions. We proved that Faradaic currents can accurately control the acidity in the cell both in aqueous and organic solvents. The microreactors provide extreme acidic environments ~10 -1 M, thanks to which, we were able to demonstrate the deprotection of -Boc acid labile groups. The reactor delivers a neutral acid that can be used for the control of many chemical reactions with the Naf ion coatings that isolated the electrodes.