Micro-scale self-propelled objects has been a rapidly expanding field in soft matter physics due to wide-ranging applications in cell biology and medicine. Numerous studies have shown that surface distortions generated by harnessing external energy can lead to self-propulsion of robotic microswimmers . Equally intriguing is the directed self-motion of particles in a bath of passive solute, where interfacial phoretic effects play a role: examples include charge gradients (electrophoresis) , thermal gradients (thermophoresis) , surface tension gradients (Marangoni effects) , and concentration gradients (diffusiophoresis) . This paper focuses on chemotaxis of bacterial microcompartments (BMCs) driven by non-ionic diffusiophoresis and hydrodynamics.