between 0.6 and 0.7. For the "everything out" validation strategy (evaluating on combinations containing no training compounds), most models produced a CCR between 0.5 and 0.55, and a PPV between 0.5 and 0.6. This difference in results between validation strategies matches the expectation of "everything out" being a more challenging modeling task. For both validation strategies, y-randomization produced validation statistics consistent with random predictions.