When water is the solvent, we find that with SM12, SM8, and SMD, the value of R 2 increases, and the value of the MUE and RMSE decreases for ln γ ∞ i,j . The difference in behavior results from a systematic error when water is the solute, where when ∆G self i,i for water is also predicted, we obtain a convenient cancellation of errors. We note that we find the values of AAPD to be less informative as the value can be dominated by just a few systems.