KLIFS structures are filtered as described in detail in the KLIFS data section (Table ), then encoded and compared as described in the KiSSim methodology section. When considering structures in DFG-in conformations only, 4112 fingerprints representing 257 kinases result in a 4112 × 4112 structure distance matrix and -after mapping structure to kinase pairs as described in the Kinome-wide comparison section -in a 257 × 257 kinase distance matrix (Table ).