First, we observed that the absence of the superoxide dismutases Sod1 and Sod2 severely increased the sensitivity of the yeast cells to the compound (Figure ). At 5 µM, the growth of Δsod1 and Δsod2 mutants was decreased to, respectively, 5.5 % and 20 % of the growth of the untreated cells whereas the growth of the parental cells was not affected at 20 µM. This clearly indicated that 11b acts, at least in part, via the generation of an intracellular oxidative stress, as observed for the antimalarial benzylMD plasmodione in yeast model. It has been shown in previous work, that the plasmodione metabolite, 3-benzoylMD PDO can act as subversive substrate of the NADH-dehydrogenases (and possibly other flavoenzymes)