Broadly speaking, this means that the most important parameter for the commercialization of these new drug delivery systems is the development of simple and effective methods. For this reason, the first part of the manuscript is devoted to the production methods for these particles and how they have evolved in response to the general needs in the field. The main conventional production technologies for CSHNs can be divided into two main categories, namely, single-stage and two-stage processes, which in turn are subdivided into different subgroups, as shown in Figure .