We commenced our studies with quinazolinone 1a and N-ethylacetamide 2a as the model substrates and selected reaction conditions are listed in Table . The desired product 3aa was afforded efficiently in 86% yield by using TBPB as oxidant reagent and 40 W Blue LEDs (455 nm) as irradiation source for 48 h (Table , Entry 1). The reaction conditions were further optimized with these encouraging results in hand. No reaction was detected without irradiation which illustrated the critical role of the light (Entry 2). And relatively low yield of target product was obtained under irradiation with a 3 W blue LED (Entry 3) which emphasized the importance of irradiation power. The reaction was preferred to be carried out under argon atmosphere, a 64% yield of 3aa was still observed under atmospheric conditions. We also found the TBPB is the optimal oxidant reagent, trace product was observed when using BPO (Benzoyl peroxide) and DTBP (Di-tert-butyl peroxide) instead (Entries 4-5). Through an investigation of the amount of oxidant reagent, the yield of the target could decrease with less equivalents of oxidant reagent. The influence of the solvents was also studied, t BuOAc was the optimal one. Inspired by recent study from Phipps and co-workers, we attempted to add [Ir(dF(CF3)ppy)2(dtbpy)]PF6 as photocatalyst but trace amount of target was obtained (not shown) ,which suggested that photocatalyst is not required in this reaction. Also, the reaction rate was hampered when the reaction was carried out in a relatively low concentration, and the addition of acid like p-toluenesulfonic acid and phosphoric acid (not shown) didn't increase the yield of product significantly (Entry 9).