Target-oriented libraries usually have a single core or scaffold with one or more attachment points, usually two or three. Different substituents or side chains are added to get the desired molecules. If all conceivable combinations were considered, a scaffold that is diversified at two or three attachment locations of diversity would provide a library consisting of numerous chemicals. Generally, a subset of these compounds is often selected for synthesis, ranging from 100 to 500. The selection is made in order to effectively investigate the design hypothesis and ensure adherence to drug-like features with the help of systematic exploration ( ).