This study serves as a first step towards quantifying the effect of achieving 100% added CO2 capture in post-combustion CO2 capture plants using an MEA solvent solution. However, limitations of this study remain; the degradation framework provides only the instantaneous predicted MEA consumption rate of the system at a point in time. As such, it does not consider the effect of cumulative production of degradation compounds within the solvent as the operation continues over an extended period and their concentrations balance with removals by reclaiming; degradation compounds within the solvent may catalyse MEA degradation and thus accelerate the reaction. Additionally, although thermal and oxidative degradation mechanisms are considered in the framework, they are considered independent, and no interactions between the respective degradation compounds are accounted for. Finally, this study does not consider the catalytic effect of corrosion compounds on solvent degradation due to the complexity of the reaction mechanisms and the limited experimental data; these will also rise until balanced by removals in reclaiming. Considering the limitations highlighted above, the results presented in this manuscript should be considered predictive only for a perfectly clean solvent. Over an extended period of operation, actual MEA degradation rates are expected to diverge from those predicted by the framework, likely trending towards increasing degradation, unless contaminants within the solvent are maintained at a very low level through a high rate of solvent reclaiming. Additionally, the cases presented here are not intended to represent an optimum for CO2 capture fraction, thermodynamic performance or solvent degradation but merely to demonstrate the effect process parameters can have on each of the above. Case-by-case optimisation will be required on a project basis. However, the results presented in this work can serve to advise designers on methods of reducing or controlling solvent degradation rates.