This work represents the first large scale investigation of metal complexes as antifungal agents. Through CO-ADD, over 1000 metal-containing compounds have been tested systematically for their antifungal activity against C. albicans and C. neoformans. Similar to our analysis of data for antibacterial properties, we found that metal complexes had a significantly higher (23x) hit-rate against these fungal strains when compared with the over 300,000 tested organic molecules. These data should still be regarded as preliminary since the number of metal complexes tested is still relatively low, particularly if the immense chemical space accessible through all possible metal-ligand combinations is considered. Nevertheless, this study makes a strong case for a more systematic and thorough study of metal-based compounds for antimicrobial applications.