Summary of key results for a few other interesting molecules: ROY, Galunisertib, Rotigotine, MK-8876,LY-156735, Bicalutamide, XXIII, Axitinib and AZD8329, Target XXXI Among all the small organic molecules exhibiting multiple crystal polymorphs, ROY and Galunisertib have been shown to exhibit the largest number of fully characterized polymorphs. For ROY, twelve fully characterized crystal structures, Y, ON, R, OP, YN, ORP, YT04, Y04, R05, PO13, R18, and Y19, have been discovered. These polymorphs stem from a broad set of conformers responsible for their red, orange, and yellow colors. For Galunisertib, solid form screening experiments produced many solvates and ten anhydrous forms (form I -form X), with forms IV-VII found to be the most stable, having experimentally measured melting enthalpies within the margin of error of one another. Our approach correctly predicted all the known Z'=1 polymorphs for ROY and Galunisertib (Figure (a) and 6(b)). For ROY, the intramolecular torsion energies are known to be challenging for typical functionals used in periodic DFT and corrections to periodic DFT energies are needed to accurately rank order the relative stabilities of these polymorphs. The raw rankings from periodic DFT are shown in Figure with intramolecular torsion energy corrections discussed in Figure of SI. By incorporating conformer energy corrections using the ωB97X-D3/def2-TZVP functional, Y, R, YT04 and OP were correctly ranked to be the four most stable polymorphs at 0K matching experiments, although the relative stability between R and YT04 is the opposite compared to experiment by a very small energy difference. The relative stabilities changed slightly as a function of temperature but the energy gap remains small (Figure (d) in SI).