The external Hypercarb cartridge was connected by the FASTlab's 'long tube' (Assembled Tubing Long PET, PART #: 1135058, 42 cm) to the Alumina light SepPak cartridge at cartridge position 5. The cartridge was held secure by a clamp stand next to the FASTlab module within the lead castle. An additional 'long tube' was attached to the male end of the cartridge and passed through a small gap in the lead castle for connection to the switch valve for collection. The switch valve and collection vials were contained in a separate smaller shielded compartment to allow access to the product vial without exposure to the high amounts of radioactivity contained within the main lead castle. SepPak cartridge into the reaction vessel. The [ 18 F]fluoride/Kryptofix/carbonate mixture was azeotropically dried at 120 °C under a mixture of nitrogen pressure (200 mbar) and vacuum (-1000 mbar) using anhydrous acetonitrile (3 × 0.40 mL). Next, the reactor temperature was allowed to cool to 110 °C under a flow of nitrogen and the precursor (2; 6.0 mg, 12.2 µmol) was added to the reaction vessel as a solution in anhydrous acetonitrile (1.70 mL). Following heating at 110 °C for 10 min, the reaction temperature was lowered to 100 °C. A solution of sulfuric acid (2.0 mL, 1 M) was subsequently added and the mixture kept at 100 °C for 4 min. The reaction temperature was lowered to 70 °C, and a solution of sodium hydroxide (1.5 mL, 4 M) was added.