Given the unique properties imbued by organofluorine functional groups on a molecule such as enhanced bioavailability and metabolic stability, about one in five small molecules currently approved by the US Food and Drug Administration (FDA) in the last three decades contain one or more fluorinated motifs {Figure 1A}. Such compounds include fluoroquinolone antibiotics such as ciprofloxacin , fluorinated nucleoside antivirals such as fluoxetine , cholesterol regulators atorvastatin , fluorinated corticosteroids such as fluticasone propionate , and most recently, the HIV capsid inhibitor lenacapavir, which has recently shown remarkable efficacy in attenuating viral propagation in a late-stage FDA clinical trial{Figure 1B} . Fluoxetine, III. Atorvastatin, IV. Fluticasone propionate, V. Lenacapavir. B) Pie chart representation of fluorinated FDA-approved drugs in 2023. This data was taken from Inoue et al. Consequently, 19 F NMR spectroscopy has become fundamental in structural characterization , purity analysis , and screening of these compounds. This technique has also been used to study biological phenomena, including biomolecular structure and function , enzymatic mechanisms , metabolic pathways , drug screening , and medical imaging . Moreover, given the broad applicability of fluorinated organic molecules, the application of 19 F NMR spectroscopy for the real-time deconvolution of complex reaction mechanisms has become a primary focus for our group and many others .