Analogs 16, 20 and 39 all had QPPMDCK Papp values around 140 nm/sec, which would support the reduced CNS score, while 38 was predicted to have a value of 632 nm/sec (Table ) indicating it was the most likely of the cohort to reach the desired site of action. A full data set of QikProp metrics for all analogs is provided as a spreadsheet in the supporting information.