Accordingly, these hybrid systems could be also successfully printed into 3D scaffolds with excellent shape fidelity (Figure ). Simple addition of CaCl The described hydrogel platform offers highly beneficial properties for a variety of applications such as a sacrificial biomaterial, a component in hybrid systems as well as support material in biofabrication, namely temperature responsive physical gelation and liquefaction, tunability of storage modulus over several orders of magnitude, printability and cytocompatibility. In addition, the polymer platform of POx/POzi offers different modification strategies during synthesis and as well as additional post-polymerization modifications to further utilize and modify the unique aqueous solution properties of A-PPheOzi-A amphiphiles in different applications in the field of biofabrication, regenerative medicine and tissue engineering.