We decided to further explore this scaffold and similar ester-containing scaffolds by searching the Enamine REAL space for related compounds using the SmallWorld search engine . Since '2805 contained a primary amine in comparison to guanidinium in camostat and nafamostat, we decided to explore a larger range of terminal amines. An initial selection of amines was built into six scaffolds (Fig. ). Scaffold 1 analogs were designed by directly substituting the phenyl ring of the benzoate with a diverse array of functional groups.