We next inspect how individual transformations impact the accuracy of free energy predictions made using LOMAP 2.0 versus HiMap designs. We will use leverages to perform this analysis (Background). Briefly, leverages are the extent to which a particular observation influences its prediction in 𝚫 Ĝ𝐨𝐛𝐬 (Eq. 6). Large and outlier leverage values can result in misleading binding free energy predictions. As a statistical test, leverage values two times larger than the average can be considered outliers .