ART procedures typically involve the handling of eggs, sperm, and embryos to achieve fertilization and implantation. Techniques such as IVF and cryopreservation are now standard practices in fertility clinics worldwide. In recent years, emerging technologies like artificial intelligence (AI), genetic testing, and stem cell research have further refined ART, enhancing its success rates while addressing ethical and social implications. Furthermore, experimental innovations like in vitro gametogenesis (IVG) hold the promise of providing gametes for individuals who are unable to produce their own, potentially revolutionizing reproductive options for individuals with infertility. Noteworthy, ART is a rapidly advancing field, but the application of certain novel and emerging technologies in humans is still highly experimental, tightly regulated, and surrounded by various ethical and legal challenges. They rely heavily on animal models, which offer valuable insights into reproductive biology and the effects of various ART interventions. In this report, we explore data from the CAS Content Collection , the largest human-curated repository of scientific information, to outline the research progress in ART. We analyze the publication landscape to offer perspective into the latest advancements, to identify key emerging concepts and challenges associated with ART. We review the most discussed and emerging concepts and assess the strategies to improve ART. By exploring its scientific basis, clinical applications, and societal impact, the report aims to provide a comprehensive understanding of how ART continues to shape the future of reproductive healthcare. The merit of the article stems from the extensive, wide-ranging coverage of the most up-to-date scientific information, allowing extensive breadth of landscape analysis and in-depth insights.