To test the thermal stability of diarylethene atropisomers, solutions of synthetic intermediates 1-yne-p, 2-yne-p, and 3yne-p (comprising M1-M3 moieties, respectively) in DMSO-d6 were heated to 100 °C for 12 h. Subsequent NMR analysis revealed negligible shifts in their resonances (Figure ), demonstrating these atropisomers' excellent thermal stability even at elevated temperatures. Antiparallel diarylethenes also exhibited excellent stability under similar thermal conditions (Figure ). These experimental results corroborate with DFT-predicted high rotational barriers of 218 kJ/mol, 182 kJ/mol, and 178 kJ/mol for the thermal atropisomerization of model M1-M3 structures (Figure ), respectively. The excellent thermal stability of parallel diarylethene mechanophores and their inherent photo-inertness make them well-suited as molecular force sensors with high specificity to mechanical stimuli, offering advantages over mechanophores that are either thermally (e.g., diarylbibenzofuranone) or photochemically active (e.g., spiropyran).