The assumed product was obtained with satisfactory yield (73%). The solvents used in the course of synthesis and purification of 1-(2-hydroxyethyl)quininium bromide belong to the group of media recommended by the CHEM21 solvent selection guide , moreover, they can be easily recovered and reused in the same process. The results of the syntheses and the basic properties of quinine-based quaternary bromides with butyl (1Br), octyl (2Br), dodecyl (3Br), and 2-hydroxyethyl (4Br) are summarized in Table .