Microenvironmental stresses, such as hypoxic or low glucose conditions, upregulate the hypoxia-inducible gene HIG1 (IPR007667). It is also known as the hypoglycemia/hypoxia-induced mitochondrial protein (HIMP1). HIG1 is a mitochondrial inner membrane protein that is ubiquitously expressed. This domain is present in proteins thought to play a role in the hypoxic response. It is also present in genetic modifications of mitochondrial proteins.