We apply the problem-oriented acquisition function from Eq. 7 in the following for Bayesian prediction of optimal further calculations, first at LoFi, then at HiFi level. Oxygenated methyl ethers have been proposed as fuels, which requires knowledge on their thermochem- The exploitation of all these minima allows very good prediction of energetic and entropic thermodynamic quantities. The very high energy region of the rotor scan is hardly known but can be ignored.