The main shortcoming of the MFCC method is that all intramolecular interactions such as hydrogen bonding, which play a crucial role in proteins, are neglected. To alleviate this, several tailored extensions have been proposed, such as using classical electrostatics to correct for missing interactions, the generalized MFCC (GMFCC) method , which uses additional caps to model the severed hydrogen bonds, or a density-based embedding scheme.