The additional loading of a photosensitizing drug proved effective in achieving a combination of photothermal and photodynamic treatments, resulting in a significant reduction in tumor size and mass in a SC model of breast cancer (Figure ). response to treatment. Adapted with permission. Copyright 2019 American Chemical Society. (d-e) In vivo antitumor activity evaluation based on "one injection, multiple treatment" strategy using a COL-based hydrogel. (d) Illustration showing the experimental workflow. (e) Tumor volume progression in mice following various treatments. (f) Tumor weights at the conclusion of treatment (inset: images of excised tumors from each treatment group after 23 days of treatment). Adapted with permission. Copyright 2016, Wiley-VCH.