With these results in mind, we constructed two different atomeconomical, 16-residue QM regions in a hybrid PCVA/b-centrality approach. One QM region, referred to as b-half, was constructed by including the highest-ranked eight residues from PCVA and the b-centrality approach, respectively. If a residue detected by one scheme is already ranked higher in the other scheme, it is replaced by the next lower-ranked residue in this scheme. The second QM region, referred to as b-norm, is constructed by normalizing the two descriptors with respect to each other. Since the differences in the assigned PCVA indicators and b-centralities, respectively, of the highest-ranked residues are quite large, the first 5 residues of each scheme are included analogously to the b-half scheme, and all other descriptors for rank 6 and lower are normalized with respect to the rank 5 value. The six remaining places in the 16-residue QM region are then awarded to the six residues with the highest normalized value of any of the two descriptors.