This result indicates that a fragment binding one kinase subpocket is likely to bind the same region of other kinases. Therefore, the high chemical diversity of the generated fragment library is a rich source of inspiration for building novel kinase inhibitors. To investigate this possibility, a library of recombined fragments was enumerated in silico (using a diverse subset of the fragments only). The resulting virtual library containing over 6.7 million molecules was compared to the ChEMBL database (exact matches), indicating 99.99% of novel chemical matter. The rare exceptions of compounds with precedence in the literature include predominately known kinase inhibitors. These results clearly highlight the enormous potential of this fragment library for the design of novel kinase inhibitors.