It is important to study a molecular model comprised of a combination of fully saturated lipid, unsaturated lipid, and cholesterol to mimic cellular lipid rafts. However, saturated lipids with higher phase transition temperatures (Tm) remain in the ordered gel phase making liposome formation challenging. Therefore, we used saturated lipid DPPC (Tm 41°C) in combination with unsaturated lipid DOPC (Tm -17°C) which has better miscibility in the ordered phase yielding a more stable and organized membrane structure. In addition, we also investigated a negatively charged lipid, POPG, that is traditionally used in combination with zwitterionic lipids such as POPC/POPE/DSPC in GUVs. Due to the residing negative charge, it has been shown to help bind proteins to the surface of GUVs. A relatively low concentration of POPG is required for electroformation of GUVs in ionic solutions as it provides lamellar repulsion that facilitates the peeling of lipid layers during GUV formation. At physiological pH, both POPC and POPG have a zero-lipid intrinsic curvature (the tendency to form curved structures), where POPC remains neutral and POPG carries a negative charge. Hence, based on the metalphosphate electrostatic interaction we sought to examine if cationic metal centres in MOFs acting as Lewis acids bind to the phosphate groups of lipids and if the interaction is more prominent in a negatively charged lipid mixture compared to a neutral control POPC:Chol mix. To determine if MOF-GUV anchoring was accomplished GUVs were imaged using Echo Discover Revolve Fluorescent microscope in the FITC channel immediately after electroformation. If MOF-GUV anchoring was successful, the GUV and MOF are stationary in the examined solution on the glass slide; if the GUV anchoring is unsuccessful, the GUVs tend to be free flowing in solution as observed in our control experiments.