The result of multiple sequence alignment of E between Andes and Hantaan viruses using the tool Clustal X 2.1 is depicted in Figure . As illustrated in Figure , Andes' "HCYGACTK" and Hantaan's "HCYGACQK" are located in the same C-terminal region, a highly conserved area. The sequences of the two viruses are somewhat different in the region immediately upstream and downstream of the "HCXXGXXR" motif. These significant structural changes may explain why Andes' E "near HCXXGXXR" exhibits PID and SH2 functions.