Almost all chemical syntheses require heating or stirring at some point during the reaction. Here, we used hotplates equipped with magnetic stirrers that have also been used previously in other SDL setups . We used solid heating blocks with different inlays to accommodate different round bottom flask sizes. Currently, the appropriately sized heating blocks have to be chosen and placed on the hotplates manually by a user before running a reaction. If different sizes of heating blocks are available on the different hotplates, the software will however automatically identify and use the hotplate with a heating block that is appropriate for the currently used flask size (see software section). There is also the possibility to add chemicals to the flasks at controllable rates while they are heating or stirring on the hotplate through different syringes and/or multiport valves, which is another important requirement for many nano and advanced materials syntheses to control the nucleation and growth rate of the nanomaterials.