Another way in which we could improve MolDarting is better handling of the translational regions. Currently the deterministic way we handle the translations between darts can lead to unwanted clashes with the binding pocket since the available translational space within one darting region does not necessarily match the available space in another darting region. For example, if a ligand translates upwards within one binding pocket and darting region, proposed moves to another binding pocket will also involve an upwards translation -which may indeed result in steric clashes if the second site is sterically congested in that direction. A potential way to address this shortcoming would be to use the short trajectories we already run for defining the dihedral regions to define the translational regions. By doing this, we can better ensure that the ligand is translated to regions that are favorable by uniformly hopping to those translational regions.