Therefore, we believe it is justified to use a simple model to calculate and compare the different reaction paths. It should be noted that whenever charges are formed, the stability of the intermediates or transition states might be more strongly impacted by local electrostatic potentials. However, there is no practical way to condense the information of the dozens of confirmed systems for NOS formation into a usable model. On the plus side, the inherent simplicity of the system used does allow for a comparison of different competing mechanisms in a rather balanced way, doing away with steric constraints and potential bias in system preparation.