Microfluidic technology has emerged as a promising approach for liposome generation due to 37 its excellent control of small fluids and droplets. Among various microfluidics-based strategies, 38 the double-emulsion dewetting strategy provides an efficient and high throughput way to generate cell-sized and monodis-40 perse liposome, which has been widely employed in drug delivery, micro-reactors, synthetic cells 41 . This strategy utilizes a mi-