|∆RMSF| values compared to default GoMARTINI settings (SI Figure ). This can be attributed to the fact that GoMARTINI only forms bonds between backbone beads, and the reduced long cutoff therefore breaks important long-range contacts, which are conserved in the OLIVES model through the side chain interactions in the tertiary network. In another test, we investigated whether the non-uniform energy matrix of OLIVES could be replaced by a uniform bond energy of 5.44 kcal/mol (22.76 kJ/mol). We find that a uniform energy matrix leads to slightly worse |∆RMSF| results (SI Figure ), which merit the chemical specificity of the energies reported in Table .