Force field accuracy is of key importance in atomistic molecular dynamics (MD) simulation methods. Atomistic MD enables studying systems of interest in life sciences by a balance between computing power and precision: instead of the computationally heavy methods needed to describe quantum mechanical behavior, MD uses typically classical mechanics approximation (called force field) to reproduce molecular behavior. Thus, the validity of MD simulation studies relies heavily on the accuracy of the force field. Not surprisingly, a lot of effort has been gone into force field development since start of MD simulation studies in the 1980s .