Finally, the release for the OA-DTXL conjugates rapidly increases in the first few hours reaching a value of ~ 40% at 8h (Figure , solid red line), which is comparable with that of PEG550-DTXL cases (55±1.8%). Following this phase, the release rate for OA-DTXL reduces to return a ~ 70% release at 72h. Throughout the observation period, OA-DTXL presents a release kinetics that is comparable with that of the short PEG and this is indeed confirm also by the CG prediction that estimate a Δ𝐺 # * = -75.3 kJ mol -1 (Figure ). Note that the difference between Δ𝐺 # * for the OA- solvents LogPow computed by the Molinspiration software, and free energy barriers ∆G* across the matrix / solution interface, as determined from the simulations (sim) (see Methods 2.1.6). We report the values for 𝐾 and the diffusional exponent characteristic 𝑛 derived by fitting Eq. 5 with the experimental data.