After establishing fully orthogonal photoswitching for the 1/2 combination in solution we set out to apply this capability in multi-photochromic materials (Figure Finally, we set out to establish all-photonic molecular logic applications with the orthogonal photoswitching system. Initially, we scrutinized binary logical gate operations. When using two different selected wavelengths or combinations of two wavelengths as individual defined inputs and changes in the absorption or fluorescence intensity at a suitable wavelength in the spectrum as outputs, a variety of gates such as NOT, NOR, or OR could be realized in solution (see Figure -j and the Supporting Information for further details). This actively integrates orthogonal photoswitching with emission modulation of the fluorophore, effectively synergizing the photonic functions in a fully modular fashion. Building on this, it was also possible to construct an all-visible all-photonic molecular encoder in solution using four different light inputs and two absorption changes as outputs (see Figure -g and j). We then set out to transfer the molecular logic behavior to the solid polymer matrix establishing spatially resolved molecular computing. To this end, the binary NOR gate operations were inscribed with the actual light input signals and the resulting outputs were observable as background color. Only if both input signals are 0 a positive output in form of a blue background is observed (third row "blue" in Figure ). In conclusion, we present a fully path-independent, all-photon, and all-visible light responsive orthogonal photoswitching system. Using two indigoid chromophores 1 and 2, very high enrichment of each of the four possible states is achieved and the corresponding four different and persistent colors can be used for multi-photochromic behavior. In a three-component system with a fluorophore the complexity of the photonic behavior can be further extended.