proposed a hypothesis in which Zn 2+ ions can bind to the TLR1 TIR domain BB-loop and stabilise the conformation of the domain, which interact with TLR2 TIR domain or adaptor proteins. With the use of the NMR experiment, the authors confirmed that the computationallyobtained two modes correspond to distinct conformations of the BB-loop and that Zn binding may affect the dynamics and conformational landscape of the BB-loop in the TIR domain.