Low temperature solid-state nuclear magnetic resonance (ssNMR) is uniquely suited to offer atomic-scale structural information of PNC samples prepared at various time points in nonclassical growth pathways by vitrification at 100 K . Vitrification by rapid cryogenic temperature transfer solidifies the sample into a glass rather than a crystalline structure by limiting the time atoms can rearrange into a crystalline orientation or an alternate temperature-dependent energetically favorable orientation, thus enabling the use of ssNMR on a sample that closely resembles the native state conditions. Sample vitrification without rapid freezing technology requires the use of a glassing agent. Plunge freezing of a solution containing 60 volume % glycerol into liquid nitrogen is currently the most widely used vitrification method for DNP experiments because at this condition, the glass quality of the sample is impervious to the cooling rate history and variation from sample to sample . This approach allows us to take static snapshots of the nucleation process by ssNMR experiments under DNP conditions. Technology to achieve rapid freeze quench (RFQ) to vitrify solutions without glassing agents is not yet commercially available for ssNMR studies, but home-built RFQ setups have been used. The main challenge with an RFQ setup is the several tens of µL volume typically required for a ssNMR magic angle spinning (MAS) sample. Wilson et. al demonstrated that spraying the sample into chilled isopentane can decrease the vitrification time and minimize the concentration of cryoagents to 20% glycerol 15 . However, commercial ssNMR Bruker sapphire rotors with capped bottoms are not compatible with this approach as it is not easily feasible to separate the isopentane solvent from the sample. Alternate design setups include spraying small droplets of sample onto a cryogenically cooled copper plate, however ample sample collection and functional rotor packing still leaves room for major improvements . With the increasing popularity of DNP-NMR and electron paramagnetic reconance (EPR) studies of vitrified samples, we believe that technology for achieving rapid freeze quench without glassing agents will become available.