Epigenetic alterations and mitochondrial dysfunction are well linked to dietary supplementation. Nutritional epigenetics is a novel subfield of epigenetics dealing with the specific effects of bioactive food constituents on epigenetics and their relations to phenotypes. Elucidating the epigenetic features prompted by bioactive food components might set the stage for personalized nutritional therapeutics and enhance the understanding of how organisms respond to specific diets or nutrients. Thus, a recent study reported that fruit and juice epigenetic effects as assessed by DNA methylation are related to independent immunoregulatory routes, indicating the distinct health benefits of fruits and juices. The discovery of such differences amongst foods is the first step toward personalized nutrition. Further, adequate nutrient levels are important for mitochondrial function as certain particular micronutrients play essential roles in energy metabolism and ATP production. 532