The entropy-based analysis further elucidates the prevalence of cyclic conformers in the Q/s approach, whereas linear conformers are more common with the C/d strategy, as shown in Table . The significantly larger number of configurations available to linear conformers makes it challenging to identify all possible configurations via the automated search used in the Q/s approach. This limitation leads to an underestimation of the entropic contributions that favor linear conformers over cyclic ones, which, while being enthalpically favorable, display much lower entropy.