In summary, the first total synthesis of ginkgolide C (3) was achieved in 27 steps from commercially available starting material, concluding a journey that began more than 10 years ago. Along the way, we also completed the formal syntheses of ginkgolides A ( ) and ( ) by intercepting intermediate 28 in 16 steps, which is the shortest synthesis of these ginkgolides to date. This work serves as a platform for further synthetic and biological studies of these complex and unique natural products.