For the intrinsic clearance data, the following literature was analyzed: lidocaine , clozapine . For reports with the unit per kg, the numbers were multiplied by 70 kg, the average weight of a healthy adult. To normalize the in vivo intrinsic clearance data in the aforementioned literature to per cell, the published results that 1 g human liver tissue contains 116x10 6 hepatocytes and an adult human liver weighs 1561g on average were used.