predicted using UNIFAC and MOSCED as compared to the reference data from "Yaws' Handbook of Properties for Aqueous Systems" . The results are separated for the case of water as the solute (water in organics) and water as the solvent (organics in water Within the Yaws' reference set where water is the solute, the SM12 universal continuum solvent model made predictions for 90 systems, UNIFAC modeled 87 systems and MOSCED 53 systems. When water was the solvent, the SM12 universal continuum solvent model made predictions for 121 systems, UNIFAC 114 systems and MOSCED 61 systems. MOSCED in both cases was the highest performer, yet modeled the lowest number of systems due to its limited compound inventory. We additionally note that the MOSCED parameters for water were optimized using limiting activity coefficients from "Yaws' Handbook of Properties for Aqueous Systems" . Overall, all models seem to have more difficulty predicting ln γ ∞ i,j when water is the solute. UNIFAC is the lowest performer in both cases. A plausible reason for the SM12 universal continuum solvent model's improved accuracy over UNIFAC could be due to the cancellation of errors that occurs in computing ∆G self i,i and ∆G solv i,j consistently.