Degrader 14 bound with a similar pose to the parent scaffold BDO1A383, with the isoxazole oxygen forming the typical hydrogen bond with the highly conserved Asn140 at the bottom of the binding site, and the benzimidazole moiety packing between Pro82 in the WPF shelf and Leu92. The linkerthalidomide portion protruded into the solvent and was not resolved in the crystal structure (Figure ).