Without RL-AL, the MPO score for runs with both oracles increases steadily as a function of oracle calls to a final value between 0.5 and 0.75. In the case of the ROCs oracle, the MPO score increases rapidly and levels off near 0.9 after ~ 10 000 oracle calls. However, in the case of RL-AL with ADV, the MPO score rapidly increases to ~0.7 and levels off, comparable to the baseline RL state. Investigating this difference, we determined that, while the docking score was rapidly optimized there was a commensurate loss of other components, such as QED, that prevented effective improvement of the MPO score. We hypothesize that this is due to conflicts in the scoring function, for example the addition of hydrogen bond donors might improve docking sores by providing more interactions with the target but push the compound out of the suitable range defined in the QED component.