Despite the significant attention that C(sp 2 )-C(sp 3 ) cross-electrophile reactions have received over the past decade, it remains difficult to translate this methodology to complex, medicinally relevant substrates. Given the high value of compounds containing alkylated arene groups in the development and study of pharmaceuticals, a robust and generalizable method to form C(sp 2 )-C(sp 3 ) linkages with medicinally relevant substrates would be valuable for drug discovery. To this end, we tested the compatibility of our reaction conditions with aryl halides from the MSD Aryl Halide Informer Library, as these compounds were at one time intermediates in drug discovery programs. Using standard high-throughput experimentation (HTE)