1,3-Diphenylisobenzofuran (DPBF) was employed as a chemical probe to evaluate the ROS generation production. 10 mg DPBF was dissolved in 1 mL DMSO to form a stable solution (37 mmol L -1 ). An amount of EH@Ag2S (50μg mL -1 ) was dispersed evenly in a quartz cell, and then 50 µL DPBF-DMSO solution was added. After continuous US irradiation (1.0 W cm -2 , 1.0 MHz, 50% duty free), the absorbance changes of DPBF at 424 nm were recorded to quantify the ROS generation rate.