Another variable was the choice of surfactant, which leads to variations in the nature of the nanomicelles (i.e., the nanoreactors) formed in the aqueous micellar medium in which the couplings take place. Thus, a series of amphiphiles was evaluated in terms of effectiveness at ena-Table . Screening of reaction conditions. bling aminations (Table ). Under otherwise identical conditions (2 wt % of each surfactant in water), yields of 1 ranged from 27 to 99%. The recently introduced, more polar and biodegradable Savie 51 gave the best result for this model coupling (entry 6; 99%) as compared to other ionic and nonionic amphiphiles (entries 1-3, 5, 7-11). The corresponding background reaction "on water" 56 (entry 4), likewise, afforded the desired product, albeit in a modest 51% yield.