II-VI layered hybrids (LHs) are a class of crystalline inorganic-organic hybrid materials with the general formula (MQ)L, where M = Zn, Mn, or Cd, Q = S, Se, or Te, and L is typically a primary aliphatic amine. Each hybrid layer, which contains an inorganic slab capped by organic ligands, is associated with neighbouring layers only by van der Waals forces. Quantum confinement of the quasi-two-dimensional (2D) inorganic slab leads to wide band gaps (typically in the range of 3-4.5 eV), lending these materials potential for applications such as white light-emitting diodes. Some computational studies have also predicted high hole and electron mobilities and efficient excited state photoemission due to high exciton binding energies. However, like many other 2D materials (e.g., black phosphorus, BP, and transition metals dichalcogenides, TMDCs), II-VI LHs also exhibit a propensity toward oxidation after long-term exposure to air, which limits their (opto)electronic performance as exfoliated few-layer material. We found that for an archetypal ZnSe-based LH, stability appears to be related to the length of the organic ligands bound to each layer. The ligand also impacts the materials' stability during and after exfoliation by shear mixing. It has been demonstrated that passivation of BP and TMDCs with organic molecules can significantly improve their chemical stability in the presence of H2O and O2.