In this work, we outline an extensive effort to analyze the conformers and torsional angle preferences of more than 3 million organic small molecules, using exhaustive sampling using the GFN2-xTB method across both the experimental Crystallographic Open Database (COD) and multiple sets of small molecules, including PubChemQC. We compare the potential bias between the crystallographic and gas-phase geometries and individual torsion patterns, including analysis with ωB97X-D3 with the def2-SVP basis set.