Likewise, the Gilson group has provided experimental thermodynamic data on different cyclodextrins and cyclodextrin derivatives for SAMPL, previously in SAMPL7 and for this work. Cyclodextrins are of interest because of their application towards modification of molecular properties of target guests upon com-Fig. 2D structures of host and guest series for SAMPL9 WP6 challenge. Shown is the structure of the WP6 host with the carboxylic arms denoted with R groups (left). The guests were code named G1-G13, and were primarily hydrophobic and cationic/dicationic guests (right). Experimental binding measurements for guests G3 and G12 were obtained with racemic mixtures of both enantiomers (marked with a (±)).