In the literature synthesis, there is an additional oxime intermediate; however, the mixed fine-tuned model's prediction follows the direct approach previously taken for trifluoromethanesubstituted quinolines by Jiang et al. ). This illustrates that the model can be fine-tuned to incorporate new reaction data without significantly compromising performance on previously learned tasks. While we used a small dataset of heterocycle formations here, this approach could be applied to a larger dataset or reaction data for different reaction classes of interest.