These authors conclude that depending on the metrics used (physicochemical properties (drug-like/lead-like), ADMET predictive properties, and the approach of the designed model) to generate these data, a great variation is observed in them due to the software, program, or web server used. This is in addition to the fact that predicting the properties of ADMET is an increasingly complex challenge for researchers, where obtaining reliable and reproducible values becomes a growing obstacle due to the exponential increase in the algorithms developed to predict these properties.