The BPE-based tokenizer is used in TRPV4-Gemma-3B to process inhibitor molecule sequence features. This enables TRPV4-Gemma-3B to rely on molecular fragment characteristics. The key mechanism of action for inhibitor molecules is their binding affinity with the target. Using BRICS (Breaking Retrosynthetically Interesting Chemical Substructures) to decompose template and generated molecules into substructures, we obtained the relationship between molecular fragments and affinity energy. Specifically, we constructed the feature matrix based on whether the molecules contain these substructures. Herein, we focus on the relationship between molecular fragments (substructures) and the binding affinity of molecules. Pearson correlation coefficients and p-values between substructures and affinity were calculated to discover substructures that contribute significantly to high affinity.