Several pandemics have occurred up till now including influenza and the recent Covid-19 pandemic. Recently, the whole world faced a pandemic known as Covid-19 which was spread across 7 continents and was declared as a public health emergency on 30 January 2020 by WHO . Symptoms of COVID-19 include pneumonia which might be sometimes asymptomatic and severe. Autopsy examinations have revealed some further symptoms of infection including edema, injuries in alveoli, vascular thrombosis inflammatory cell infiltration, etc. . Scientists and researchers utilized both conventional as well as modern techniques to find solutions for the pandemic control . Several outbreaks of this virus have led to the rapid development of vaccines for SARS Cov-2 which is an outstanding achievement for scientists . Moreover, the available antiviral drugs are not that effective as they work for the early stages of Covid-19 only. Pfizer was the only vaccine approved by the US FDA . The pandemic has also highlighted the significant gaps in the knowledge that exist for the 2 viruses that had the potential of creating a pandemic situation i.e. Coronaviruses (CoVs) and influenza virus infections . There is an urgent requirement to develop vaccines for Covid-19 caused by coronaviruses including SARS-CoV-2 and the old SARS and MERS. The receptor binding domain (RDB) of the spike domain might be an attractive and effective target for vaccine development but is not that effective due to the restricted immunogenicity of this receptor .