In addition, our protocol was not hindered by the position of the Dha residue in the peptide, as the functionalization at N-, C-terminus as well as inside the peptide sequence was accomplished. Furthermore, our methodology facilitated the rapid synthesis of a tripeptide 66, which showcased an atypical linkage, demonstrating the applicability of our ligation techniques. This process also proved to be highly capable at integrating drug scaffolds with peptides, further emphasizing the remarkable functional group compatibility of our system, even within the intricate context of peptide conjugation