The BE-block reduces the number of peaks. This property can partly lift the signal congestion in large systems, and systems with a high degeneracy of the amino acid type, such as membrane proteins. As another example, the relaxation measurement needs a series of high-dimensional experiments with a good signal separation for accurate peak intensity quantification, and it is strongly time-consuming. The 15 N-1 H type experiments are frequently used to quickly characterize the protein backbone dynamics, but suffers from the signal congestion. The caNH type BE experiments can be used to simplify the H-N resonances. In case of Bacteriorhodopsin, a typical membrane protein, ~40% of the amino acid are hydrophobic or aromatic such as Val, Leu, Ile, Phe, Tyr, and Trp. The BE block with the BE-2 pulse eliminates 34% of these signals corresponding to Leu, Ile, Phe, and Tyr, without any sample modifications. The resultant spectral sparseness is also favorable for NUS. Thus, the BEexperiments help accomplishing the rapid and accurate relaxation measurements. These abilities should also prove useful for the analysis of large proteins in solution.