The literature search revealed that the number of peer-reviewed papers found in PubMed and Web of Science using the search terms described in the Methods section was 7,430 and 5,960, respectively; of which 4,484 were in both databases and 2,946 were unique for PubMed and 1,476 were unique for Web of Science. Table summarizes the major twenty types of diseases associated with epigenetics, and chemical compounds present in the food or natural products identified in the current search are listed. at least one of the targets, and 66 compounds have reported general activity against at least one target family. The Epi Food Chemical Database contains ten columns with general information plus forty-nine columns that encode the epigenetic activity profile of the compounds across forty-six epigenetic targets.