With the amplifier, the internal energy distribution was slightly higher in energy and narrower in the presence of 50% methanol, which could be ascribed to incomplete desolvation from purely aqueous solution (the Venturi effect accelerates the droplets, but does not cause enough turbulences for droplet desolvation). This contrasts with another study of the same group, without Venturi air amplifier and a different MS inlet, which showed lower internal energies in 50% methanol than in pure aqueous solutions . These examples illustrate the difficulty of drawing general conclusions from isolated small-scale studies performed with specific source interfaces.