First, all mutations mentioned above were ADV blind-docked (60x60x60 Å grids) to ~ 200 BTA-derived top-children. The resulting ranking profiles (n= 2-3) identified two groups of mutations. The first group included most of the fusion-resistant mutations predicting sub-nanoMolar affinity ranges (Figure A, different colors), such as those targeting the top-surface, bottom-surface and some of the bottom-drug sites. Most probably their distances to the drug site could not detect by docking any of their possible allosteric interferences (Figure ). The second group included only F140I, F488I, and D489Y predicting ~100-1000fold lower affinities than those of the first group (Figure A, larger circles green, red, cyan, respectively). These 3 mutations belonged to those surrounding the drug site (Figure B, green).