In this paper, the voltammetric response of pH-sensitive Aβ(4-16)-Cu(II) complexes, Aβ (4-16) peptide and tyrosine at different pH values (from 5 to 9) are examined in order to understand the influence of tyrosine (Tyr) deprotonation on the Cu(II)/Cu(III) reaction. Experiments were performed at high (100 Vs -1 ) and lower scan rates (0.1 Vs -1 ) (CV) and at different frequencies (SWV) in order to the investigate interaction between Cu(III) and Tyr and determine the rate of this reaction. Additionally, electrochemical studies were supported by simulations. The results will help to better understand the scavenging role of tyrosine in quenching highly reactive Cu(III) ions in Aβ-Cu(II) complexes. Ag/AgCl. Prior to each voltammetric measurement the GCE was polished on a Buehler polishing cloth to a mirror-like surface, using aqueous slurries of 0.05 μm alumina powder followed