We set out to (1) assess the feasibility of electron counting applied to small molecule MicroED data collection, (2) determine the potential benefit of fast EBEC for detection of accurate diffracted intensities from small molecule crystals by MicroED, and (3) evaluate the impact of CL and a CL adjustment on small molecule MicroED. Compared to the Ceta-D, the detector of record in a large fraction of the deposited MicroED structures in the PDB, EBEC data collection facilitated more rapid data acquisition, thereby yielding high-completeness single crystal diffraction datasets that were less impacted by beam-induced radiolytic damage. Attempts to acquire data as rapidly using the Ceta-D, matching the stage rotation speed (2 °/s) and frame rate (2 frames/s) used in the fast EBEC experiments, yielded data with inferior reduction statistics. In particular, for data collected on the salen ligand with an incident beam flux of 0.01 e -/Å/s and fast rotation of 2 °/s, overall R merge statistics from these Ceta-D datasets were more than double what was achieved with fast EBEC (Supplementary Table ). For this comparison, overall I/sigma statistics were twice better using fast EBEC. That discrepancy was less dramatic when the same comparison was made with a higher incident beam flux of 0.045 e -/Å/s (Supplementary Table ). Nonetheless, statistics from fast EBEC data were preferable in all cases.