Traditional laboratory-based procedures for protein biomarker identification can be time-consuming and invasive to acquire a sufficient amount of blood. Moreover, good medical care can be expensive, promotes the risk of infections to the patient or sample hemolysis, and require specialized equipment and skilled personnel . These factors make it challenging to implement POC testing using current methods of blood extraction, particularly in resource-limited or remote settings. POC testing tentatively provides an alternate technique, allowing for the detection of protein biomarkers faster, cheaper, and at the patient's bedside or in the doctor's office, even at home settings, without the need for laboratory equipment or specific training . Many POC diagnostics rely on the sampling of blood by venepuncture, which is a procedure that requires a healthcare professional and can be painful and uncomfortable for patients . The limits of present technologies can be overcome by creating alternative blood extraction-free approaches, such as on-chip nanostructured devices. Furthermore, the simultaneous measurement of multiple bioanalytes in a single sample is highly desirable, offering fast, inexpensive, and reliable quantification. Therefore, applicable multiplexed POC testing which tackles all of the aforementioned challenges has become a major point of interest, and serves as a holy grail for medical diagnostics.