In investigating the interaction between Tat and the tetramerization domain of p53, our approach initiates with the docking of the two proteins utilizing three docking servers (refer to the experimental section for comprehensive details). Subsequently, the best ten models generated by each server are scrutinized in comparison to those produced by the other servers, according to the position of Tat relative to that of p53. Following to this comparative analysis, models exhibiting similarities are filtered, thereby reducing the total count of models to four (Figure ). This is achieved through the visual examination of Tat/p53 complexes with VMD. The names of these four distinct models in this manuscript and the servers they originate from are delineated in Table .