As described in the Compound Selection section in Materials in Methods, twenty-three compounds were ultimately investigated in the work. Where it was possible to calculate acid dissociation, the results are provided in Table along with a standardized compound identifier (beginning with "SAMPL8-X"), the molecular scaffolding structure, molecular weight, and the pH range tested for the drug substance. From the twenty-three molecules that were tested for pH-solubility to determine pKa, automated logD experiments were successfully conducted for eleven molecules. The eleven that were successful are presented in Table and are composed of four weakly acidic compounds (SAMPL8-1, 3, 5, 6) and seven weakly basic compounds (SAMPL8- .