In the musculoskeletal system, bulk flow occurs in vascular and interstitial flows within bone marrow and between muscles, enabling the convective transport of substances around and within the tissues through the extracellular matrix. Convection also contributes to the spread of inflammatory mediators or the accumulation of metabolic byproducts in musculoskeletal tissues . For instance, in rheumatoid arthritis, inflammatory chemicals are through synovial fluid, contributing to joint inflammation and damage. Blood flow provides a primary convective route in bone remodeling, delivering nutrients and signals necessary for osteoclast and osteoblast activity . Impairments in transport, due to either systemic vascular conditions or localized disruptions, can lead to metabolic bone diseases such as osteoporosis .