In this study, we provide a first computational investigation, at the density functional theory (DFT) level, into the chemical transformations underlying the reactivity of BLG/methanol interfaces in the 0-10 GPa regime and room temperature. The system has been simulated in a suspended geometry using ab initio MD. The adoption of a suspended geometry allows us to focus on the effect of out-of-plane stress on the structural and chemical evolution of the BLG/methanol interface.