To demonstrate the practicality of the disclosed protocol, the synthesis of C4-functionalized α-Dgalactoside 3a was carried out on 1 mmol scale under continuous flow conditions (Fig. ), displaying the same yield (68%) and stereoselectivity (Gal/Glc 1:0) as for the small-scale batch reaction (69% yield, Gal/Glc 1:0). Furthermore, deprotection of the silyl ether group from 3a could be carried out under benign conditions to produce either spirocyclic lactone (6a, 93% yield) or linear fully-unprotected C4functionalized product (7a, 68% yield) in high efficiency. Notably, the majority of contemporary protocols for C-H functionalization of unprotected carbohydrates via intermolecular HAT employ acidic cocatalysts, which promote the lactonization reaction in situ and prohibit isolation of the linear coupling products, such as 7a.