CBL is a proto-oncogene that encodes a RING (interesting new gene) finger E3 ubiquitin ligase. This gene has been found to be mutated or translocated in many cancers including acute myeloid leukemia. The GRB2 is a Growth Factor Receptor Bound Protein 2. Its activation through some specific RTKs (Receptor Tyrosine Kinase), in our case PDGFRB-class III, VEGFR3 (FLT4)-class IV, FGFR2class V, and TEK-class IX, certifies its involvement in breast cancer progression, and its abnormal activation by ERBB2 is related with the development of human breast cancers and mammary carcinoma (Figure ). NOTCH1 is one of four known genes encoding the NOTCH family of proteins, a group of receptors involved in the Notch signaling pathway. Increased expression of Notch receptors has been observed in a variety of cancer types including cervical, colon, head and neck, lung, renal, pancreatic, leukemia, and breast cancer. Activation of Notch1 among other Notch family proteins has been shown to cause mammary carcinomas in mice. PDGFRs (Platelet-Derived Growth Factor Receptors) are catalytic receptors that have intracellular tyrosine kinase activity. Its activation induced epithelial-to-mesenchymal transition and led to Basal-like breast cancers. TEK (Tie2) is one of RTKs that belongs to TIE family and along with VEGFR encodes angiogenesis in cancer patients. The mentioned proteins participate in 75 pathways with 22 of them directly involved in cancers (Table ).