We now apply our QM methodology to cases employing a Pd catalyst with one of the following ligands; DPPP, DPPE, or (PPh 3 ) 2 for both the neutral and cationic pathways. We remove 31 reactions due to convergence problems and an additional 10 that have several reaction sites (we discuss these separately below). These 41 reactions all produce the β isomer experimentally, leaving us with 2,947 such cases. Using the neutral pathway we predict the α and β isomers for 7 % and 64 % of the reactions and a mix for the remaining 29 %, while the corresponding percentages for the cationic pathway are 32 %, 37 %, and and 31 %. Thus, our method predicts that the intermediates associated with the α and β isomers are very similar in energy (< 3 kcal/mol ≈ 12.6 kJ/mol) for close to a third of the reactions, while a mixture is reported for only 2 % of the cases. In 26 % of the cases both pathways agree on a regioisomer or a mix and these calculations agree with experiment in 3 %, 88 %, and 3 % of the cases for α, β, and mix, respectively. Thus, if both pathways predict the β isomer, then there is a good chance that this will be observed experimentally; however, that is not the case for the α isomer or a mix.