DNA nanotechnology evolved from the predictable WC sequence-structure relationship of DNA, which enables the self-assembly of nucleic acids into programmable shapes and patterns; and until now it has almost exclusively relied on WC base pairing . Scaffolded DNA-origami is a particularly interesting self-assembly methodology, because it uses 200-250 unpurified short staple strands to fold a typically 7249 nt long single-stranded DNA scaffold into neararbitrarily shaped 2D and 3D nanostructures . These nanostructures are uniquely addressable and can therefore function as templates for other materials . In combination with the broader chemical repertoire of switchable DNA interactions , such as aptamers, G-quadruplexes, and triplexes, a range of dynamic objects, molecular machines, and other functional devices have been designed . RNA origami as well as the DNA brick and tile methodologies are exciting further developments. However, all of the above-mentioned methods are fundamentally limited, because WC base pairing can only fold single-stranded DNA molecules. Arbitrary spatial organization and mechanical manipulation induced by folding of double-stranded DNA requires another binding motif. This has been attempted in two cases: Praetorius and Dietz used 16 fused TAL-proteins and Wu et al. used bivalent CRISPR/dCas proteins to fold dsDNA scaffolds, but the resulting structures were considerably smaller than DNA origami and did not have "pixels" addressable via DNA hybridization.