Waste plastics are environmental pollutants, yet also represent an untapped chemical resource. Among millions of tons of synthetic plastics generated annually (constituting >30% polyesters ), a mere 12% is recycled worldwide. The micro-and nano-plastics accumulated in soil and marine biomes are challenging to recycle due to their low concentrations and small sizes. Extracting value from waste plastics requires processes that yield products at low environmental and economic costs. The discovery of plastic-degrading hydrolases opens a new avenue for polyester depolymerisation, by which the enzymatic process scan be performed at near-neutral pH (~6-8), and moderate temperatures (25-65°C) with low operating costs. Active polyethylene terephthalate (PET) hydrolases have been reported, such as IsPETase (obtained from I. sakaiensis) , and its more robust variant DuraPETase (Dura) with a 300-fold enhanced activity on PET degradation (crystallinity 30%) compared to the original at 37 °C. Enzymatic plastic degradation also demonstrated industrial feasibility with a variant of leaf-compost cutinase (LCC) depolymerising post-consumer PET waste with low energy input. However, enzymatic depolymerisation has only been demonstrated as a preliminary step for virgin-grade PET regeneration, in which the product range is limiting and of low value. Here we explore an alternative valorisation route to unlock the full potential of enzymatic depolymerisation to generate products of greater economic significance from waste plastics.