A search for co-occurrence with proteins showed that ALS exhibits the highest cooccurrence with TDP-43 (Figure ). TDP-43 (TAR DNA-binding protein 43) is a key pathological hallmark associated with ALS and related motor neuron diseases. Loss of TDP-43 from the nucleus and abnormal accumulation of TDP-43 aggregates in the cytoplasm of affected neurons is a prominent pathological feature observed in the majority (>97%) of cases, particularly in sporadic ALS. TDP-43 pathology correlates with disease severity and progression, suggesting a central role in ALS pathogenesis. While HD etiology has been traditionally associated with abnormalities in the huntingtin protein, recent research has explored the involvement of β-amyloid and tau (τ) protein, typically associated with Alzheimer's disease, in HD pathology, as reflected by the frequent co-occurrence of these proteins with HD in the CAS Content Collection (Figure ). Studies have shown the presence of β-amyloid deposits as well as elevated levels of phosphorylated tau in the brains of HD patients, particularly in regions affected by neurodegeneration.