Infrastructure requirements significantly affect financial viability and environmental sustainability. Treatment systems need contactors, pipes, fittings, and corrosion-resistant coatings. The infrastructure for resin treatment and regeneration is assumed to be twice as complex as that for GAC due to its added components. is the second most impactful system after single-use GAC because of the additional infrastructure and chemical-intensive regeneration processes. Although capital impacts are generally minimal, they are significant for single-use IX due to its low media usage rates. For reactivated GAC, the absence of high-temperature incineration shifts more impact to infrastructure requirements for regeneration. Energy consumption significantly affects the financial viability and environmental sustainability of PFAS treatment technologies. High energy use increases production costs, making technologies less efficient. GAC adsorbents production and reactivation consume substantial energy, leading to higher life cycle impacts like fossil fuel depletion and respiratory effects. Thermal reactivation of GAC adsorbents, at 815°C, is less energy-intensive than incineration at 1200°C, making it more cost-effective. Regenerable IX systems also increase energy demand due to the salts used in regeneration, especially those derived from chemicals(e.g., NH4Cl, K2CO3). Both GAC and IX systems are sensitive to local electricity grid variations, affecting costs and environmental impacts. The prioritization of indicators through ranking and weighting guides the final sustainability assessment. For example, the MIVES model was used to integrate results from environmental, financial, and social assessments for GAC and IX under different weighting scenarios. The scenarios included equal weighting of all indicators (33% each), higher weighting on social impacts (60%), and higher weighting on financial viability (50%). The results suggested that IX treatment is generally more sustainable than GAC treatment. By following this framework (Figure ), we can identify the most sustainable treatment