Parameters for the Hill equation were selected to be comparable to mass spectrometry measurements of enzymatic inhibition assays from the COVID Moonshot: ? R b and R t were set at 0.227 and 54.074, while H was fixed at 1 and x 50 at -6.0759. For the simulated curves, 10 concentrations were used, with the highest concentration at 100 µM and the others diluted by a factor of 5 each. Random Gaussian noise with mean 0 and variance σ 2 c was added.