The radiofluorination followed an adapted protocol developed by Hoffmann et coworkers. No carrier-added [ 18 F]fluoride was produced via O(p,n) F nuclear reaction by proton irradiation of O-enriched water and sent to a [ 18 F]fluoride incoming reservoir. [ 18 F]Fluoride solution (1 mL, 500 -5000 MBq) was passed through a carbonated quaternary methyl ammonium cartridge (QMA) through the male side to trap [ 18 F]fluoride (Reverse loading-elution protocol). The [ 18 F]fluoride was flushed with n-BuOH (2 mL) and then eluted with a solution of Et4NOTf (1 mg, 3.6 µmol) in n-BuOH (400 µL) in a solution of the precursor 42 (1.05 mg, 2.5 µmol, 1 eq.) and Cu(Py)4(TfO)2 (6.78 mg, 10 µmol, 4 eq.) in DMI (800 µL). The reaction mixture was heated for 10 min at 110 °C under atmospheric air and then left to cool down for 5 min to rt.