The canSAR chemistry (canSARchem) registration and standardization pipeline sought to fill this gap, and it was developed as a standalone pipeline to address tautomerism and the challenges in FAIR (findability, accessibility, interoperability, and reusability) medicinal chemistry and pharmacology data. It also underpins the chemistry components of canSAR , which is the largest integrative drug discovery platform primarily focused on oncology, and being utilized in other resources . The first version of canSARchem addressed the standardization and tautomerization challenges while providing a fully automated workflow freely available to the hydrogen-bond donor to a hydrogen-bond acceptor along with shifts in double bonds or ring openings or closings can lead to multiple possible forms of the same molecule that are capable of interconverting. While each form is technically chemically correct, existing chemical registration tools do not recognize them as chemically equivalent. This often results in duplicate entries within a database as different tautomeric forms and artificially separates their associated bioactivity data. This separation of data can be remedied through grouping registered molecules that undergo tautomerization under a single representative tautomer - , and this is an aim of our pipeline.