Finally, to probe the extent of possible underestimation by the naive method, we repeat our analysis on this site for all possible snapshot measurement times. The largest instance of underestimation was by a factor of 36.4x and 64.8x compared to the mean and maximum estimate from the PDM, respectively. More details about this case study, including two additional hypothetical snapshot measurement examples, are given in Sections S9-S11 of the SI file.