Table illustrates that the EEEV virus P protein contains a potassium channel-like domain: Ion transport, Ionotropic glutamate receptor L-glutamate and glycine-binding, Neurotransmitter-gated ion-channel ligand-binding, Neurotransmitter-gated ion-channel transmembrane, Polycystin cation channel PKD1, Potassium channel, Potassium channel inwardly rectifying transmembrane, Potassium channel voltage dependent Kv4 C-terminal, UPAR. Throughout the entire sequence, the neurotransmitter-gated ion-channel transmembrane domain remains active, indicating that the EEEV virus P protein inserts itself into the synaptic membrane as a potassium ion neuronal channel. Neurotransmitter-gated ion channel ligand binding is active along the whole sequence. This means that the EEEV virus P protein may be able to use its potassium channel-like function by attaching to neurotransmitter ligands. This process guides the synaptic membrane to generate vesicles that encapsulate the EEEV virus and internalize them in the synapse.