Across the board, a high importance of solvent is observed, with dependencies based on differing reactomes. For example, In the ArI + aromatic nitrogen (3 unique reacting pairs) and ArI + 2˚ alcohol couplings (2 unique reacting pairs), dioxane and DMAc are favored, respectively. For ArBr + 1˚ alcohol's reactome (2 unique reacting pairs), these two solvents are revealed to have less importance. In fact, the solvent of importance, allyl alcohol, is also the nucleophile in these couplings. In this subreactome, ligand identity plays a significant role in yield determination. Finally, for the ArI + 1˚ alcohol's reactome, reaction temperature is a leading factor, a point which is of no surprise . It was expected to also see some importance placed on temperature for the other 3 subreactomes, but due to HTE design, temperature remained nearly constant throughout the entire subreactome, eliminating it as a variable.