Recent molecular dynamics simulations have shown that different deformation modes with the same functional group, the activation barrier has a significant dependence on the mode. A study of how rotational strains in mechanophores affects the pulling stress needed to induce isomerization showed that the total work to induce reaction (work to rotate + work to pull) is less, with increasing rotational work. Additionally, coupled out of plane strains and compressive work for the graphite to diamond phase transformation showed lowered barriers but slowed kinetics due to defect formation. These results beg the question as to whether or not mechanochemical influence on reaction rates is more or less efficient than pure thermal chemistry, under a total input energy budget. Therefore, we form a theoretical framework, based on Arrhenius kinetics, to model mechanochemical reaction rates for complex deformations, validate this model against molecular dynamics simulations, and utilize it to explore the overall efficiency of mechanochemical reactions.