Routine NMR sample preparation has an inherent drawback-the sample dilution, which results in two-fold costs-at least two to the threefold lower sensitivity of the NMR experiments; and a waste of expensive deuterated solvents. Reducing the quantity of deuterated solvents without losing its certain and obvious advantages, and reducing experimental time is highly desirable. In a conventional 5 mm o.d. sample tube, the 0.55 ml deuterated solvent fills the lowermost 4 cm of the 7 to the 9-inch long tube. This 4 cm sample is positioned symmetrically about the most sensitive part of the probe's detection coil, typically 1.8 cm in length. Thus, 0.55 ml is considered the standard volume, and 4 cm sample length is the typical standard sample length, although 0.7 ml volume in a 5 cm sample length is also used often providing marginally better sensitivity and lineshape. Practically, more than half of the sample is outside the sensitive area (1.8 cm coil). However, this arrangement minimizes field distortions in the sample volume, which otherwise degrades lineshape, resolution, and sensitivity. Reduced volume samples that exactly matches the 1.8 cm long coil are solvent-effective but offers poor spectra relative to the standard sample (4 cm). For a large diameter probe, concentrating the small amount of sample within a small diameter tube does not improve sensitivity. However, for such sample small-diameter probe such as a microcoil NMR probe provides higher sensitivity, which comes at additional hardware costs and in a specialized environment. Reducing solvent and enhancing sensitivity has always relied on costly alternatives, such as Shigemi tubes and specialized micro-coil/small-volume sample-tube (for mass-limited samples). Solvent susceptibility matched Shigemi tubes not only reduce the requirement of the solvent amount to 0.25 ml (1.8 cm) but also enhance sensitivity for 1 H as well as 13 C NMR.