The P-TN-Dox and P-TN-Dox@CM nanogels presented similar superior temperature rises as that of P-TN nanogels, suggesting that the Dox loading and cell membrane coating had negligible impact on the photothermal properties of nanogels. Additionally, the temperature rises of P-TN-Dox@CM nanogels exhibited concentration-dependence (Figure ) and laserpower-density-dependence (Figure ). Moreover, the photothermal stability of P-TN-Dox@CM nanogels was further assessed. It was found that P-TN-Dox@CM nanogels still carried robust photothermal conversion ability after five on/off cycles of continuous 808 nm laser irradiation (Figure ), disclosing splendid photothermal stability and repeatability of the P-TN-Dox@CM nanogels, which could be assigned to the harvesting energy by intramolecular mobility from molecular rotor with strong electron-donating performance. These results demonstrate that P-TN-Dox@CM nanogels can convert energy of NIR light into heat rapidly and efficiently, and the resultant hyperthermia may annihilate tumor cells via apoptosis and necrosis. (e) Photothermal stability of P-TN-Dox@CM nanogel solution (0.5 mg mL -1 based on PNA) under five cycles of on/off irradiation with 808 nm laser (0.6 W cm -2 ).