Cryo-fluorescence microscopy (cryo-FM) can provide functional information such as lipid and protein oxidation , whereas cryo-transmission electron microscopy (cryo-TEM) provides structural information of proteins and potential aggregation upon oxidation . Correlating the information from cryo-FM and cryo-TEM is, however, not trivial . A major challenge is to find the same location in emulsions from cryo-FM and cryo-TEM. One option is to use finder grids that have each grid square marked by specific letters; thus, the same sample positions can be readily monitored in both cryo-FM and cryo-TEM. An alternative approach is to generate markers on the EM grid by devitrifying the ice on purpose using high laser intensities. This approach has the advantage that markers can be made on any type of grid.