In order to determine if the nSPS scores are related to the general trends in compound activity and selectivity, and how those trends relate to Fsp3 and FCstereo, we analysed the ChEMBL database, selecting only for molecules tested in assays with the highest confidence score. Retention of the assay outcomes with the highest confidence score assured that the used results are accurate and the target assignments represent the actual targets. Compound activity was assessed based on the averaged available pChEMBL values for a given molecule. The pChEMBL value is a negative log of concentration-response activity such as IC50, EC50, Ki or Kd. The analysed structures were classified as compounds with low (average pChEMBL ≤ 5.3), medium (5.3 < average pChEMBL < 6.5) or high activity (average pChEMBL ≥ 6.5).