The popularity of HTE is still increasing and it's approached from many different angles. We built our dream HTE lab from scratch and this is what we learned: HTE should be the rst line of defense, not the last hope. Thus, we encourage our customers to contact us early. HTE is great for quickly exploring chemical space and generating leads. Yet it is no panacea. Reaction miniaturization and execution in the glovebox improve robustness and reduce material consumption. But that also means that not everything will work on a larger scale in the lab. It's our job to anticipate problems and design plates with the customer's intention in mind. Based on the cheat sheets (Ref. 14) and our own data, we assembled a set of recommendations for Suzuki-Miyaura and Buchwald-Hartwig coupling. These are part of the supporting information.