Solvent II: 2x simulated gastric fluid without pepsin (SGFsp) was prepared as reported in literature 66 but adjusting the pH to 0. 0.4 g NaCl were dissolved in 85 mL milliQ water, followed by addition of 8.5 mL of HCl (32%). The pH was then adjusted to 0 and the volume diluted to 100 mL with milliQ water.