Compared to cyclic peptides 15c and 16c, a rather mild dye leakage action was observed for daptomycin, with only 34% of dye release at 50 µg/mL after 100 min incubation with bacterial membrane mimicking liposomes (Figure ). Noticeably, when treated with mammalian membrane mimicking liposomes, both 15c and 16c, even at the highest experimental concentration (50 µg/mL), induced insignificant dye leakage as evidenced by 12-18% dye release after 100 min exposure (Figures and). Similarly, a negligible amount of dye leakage (around 6% at 50 µg/mL after 100 min) was observed for daptomycin when incubated with mammalian mimicking liposomes (Figure ).