Considering BEDROC scores of ≥ 0.5 as indicative of excellent VS performance, the combination of DiffDock-L and Gina yielded good screening results for 9 out of 43 targets. In comparison, pose sampling with Vina achieved excellent results for 12 targets. When Vina served as the scoring function, DiffDock-L obtained excellent results for 5 targets, while Vina achieved excellent results for none.