The increase in overall yield to 87% has a large impact on the sustainability of the process. Not only does it avoid the consumption of excess solvent as in the manual batch process, it also reduces the required input (utilization factor) of advanced phthalazinone and pyrazole intermediates by over 30%. These synthons require up to 7 synthetic steps each, and so reducing the required quantity improves the process mass intensity immensely. Scaling to kilogram quantities and broadening substrate scope is currently underway. Continuous-SPACEDKR can render atroposelective synthesis a mechanical effort. So long as an investigator can find a suitable resolution agent or conglomerate form, high-yield of optically pure material can be achieved. It is envisioned that this will provide a complementary means to asymmetric catalysis for accessing axially chiral compounds which are challenging to make via catalytic methods. Further, the strategy of asymmetric DKR enabled by continuous flow likely will continue to increase its breadth to other epimerizable features which can be resolved by crystallization.