In terms of scalability Figure documents how the current reaction protocol can be adapted to gram and decagram scale using batch and flow reactor setups. Pyrimidine 3 could be accessed on a gram-scale in batch without precaution to remove air or moisture, and the reaction was complete within 4 hours (48% isolated yield, identical to the ca. 100 mg scale). Pyridine 27 could be synthesized on decagram scale using a simple and inexpensive recirculating flow setup similar to that previously re-ported. Again, no onerous precautions were taken to set up this reaction. When a premade RAE was employed a similar yield to the small scale run was observed (59% isolated yield). An in situ preparation of the RAE could be employed resulting in a lower yield of product (similar result to smaller scale, see SI for further discussion).