Different surfaces offer different interaction environments for adsorbing species. The surface shows larger interaction energies than the (001) surface for all species, except acetone. This enhancement is larger for the smaller molecules, e.g. -0.78 vs. -0.29 eV for methanol and -0.65 vs. -0.45 eV for IPA, which is likely associated with the greater steric hindrance of the larger groups, limiting their access to the inter-sheet region. The surface orientation dependence of the interaction energies means that the sensing response of SnO will be dependent on the contributions of the ensemble of planes involved and this can be useful in motivating further work to control the dominant surface facet of nanostructured SnO.