Herein, we define recall as the number of true 100, 1000, and 10 000 top-scoring compounds according to the brute-force docking approach, that had also been selected for docking by HAS-TEN. With SurA and a failed score of +5.0, we were able to recall around 95%, 90%, and 85% of the top-scoring 100, 1000, and 10 000 compounds, respectively (see Figure for top 1000 and Table ). Using the same approach with the GAK target, on the other hand, resulted in recalls of only 70%, 67%, and 59% of the top-scoring 100, 1000, and 10 000 compounds, respectively (Figure and Table ). A reason for the high number of failing compounds may lie in the treatment of hydrogenbonding constraints in Glide: With the active hinge region amide constraint, any compound with no hydrogen bond accepting group will be directly excluded from evaluation and receive the failed score. For any other compound, the initial placement will depend on its hydrogen bond acceptors: