For the Skinner model (see Fig. ), we obtain a rather similar picture. For the polyalanine models, the RMSDs increase to ca. 13.0-17.7 cm -1 , which is at least twice as large as for the isolated polypeptide models. Again, when looking at the plots and at the values obtained for R 2 , it appears that all correlation between the reference values and the vibrational maps is lost. Also for the 1GPB 3 10 -helix and for Trpzip2, there is now a noticeable increase of the RMSD (from 11.2 to 15.5 cm -1 and from 15.5 to 26.3 cm -1 , respectively) of the RMSDs compared to the isolated polypeptides, and R 2 drops below zero for both test cases.