As is evident, we have not yet explored the P2A moiety itself. Commercially available chemicals have allowed us to explore the hypothetical R3 pocket reasonably, but we will need significant synthetic effort to modify our narrow range of active chemicals (1, 2 and 4), which remains a future goal. Ultimately, this is only a preliminary report on developing some structure-activity data, and a more detailed exploration will be necessary to truly develop these observations into something conclusive, and to eventually help identify leads.