The results of the catalytic tests of iron-based catalysts with iron loadings of 1 wt%, 5 wt% and 10 wt% show excellent activity and selectivity in the acetylene hydrogenation under industrial front-end conditions, especially for the catalyst with the lowest iron loading. Furthermore, the catalytic activity exceeds that of unsupported iron nanoparticles, clearly demonstrating the improved properties of the supported catalysts.