As in the case of studying the effect of mutations, it seems that research regarding the dynamics of TLRs is just beginning. Considering the differences in TLR structure, substrate recognition, dimerisation requirements, and association with adaptor proteins, along with the importance of understanding the TLR signal transduction pathway, we can expect a significant increase in interest in this field in the coming years. Based on the results presented in the reviewed papers, we can conclude that still, the most attention is paid to the use of computational solutions for the design of small-molecule modulators. The use of in silico methods to design other types of modulators, such as multiepitope vaccines, is gaining more popularity, but yet, it is not as common as in the case of smallmolecule compounds. Both small-molecule and multi-epitope modulators are designed in such a way as to target the LRR of TLRs. There was no breakthrough in the design of small-molecule modulators targeting the TIR domain. Among things that scientists will want to keep improving is obtaining the best binding affinity and stability of the modulators. Regarding the dynamics of TLRs, scientists have shown that studying the mutations' effect can contribute to a better understanding of the potential mechanism of action of the receptors. That is of special interest for both ligand and adaptor protein binding. More demanding, both in terms of system preparation and computing power, is the analysis of the dynamics of the full-length TLR complex. So far, only TLR3 and 4 have been built as full-length models embedded in the lipid bilayer. Those studies presented relevant information on possible conformational changes that may occur in the receptor's structure. Thus, it would be very important to perform similar studies for members of the TLR family. Since now we have easier access to the predictions of large macromolecule structures, we expect that in the coming years, we will witness progress in research on the TLRs' dynamics and mechanism of action. In Figure we presented the main areas in TLR research which still require further studies. Without details about the orientation of the subunits, it is difficult to properly select the best binding site for modulators.