For the test case of finding inhibitors for a mycobacterial TrxR as antituberculotic agents, several binding fragments could be identified. Due to the design of our social library, direct follow-up compounds are available for the hits. In total, 1.3 million follow-ups are available for the 17 fragments located in the three relevant binding pockets described above. This means that, on average, roughly 77 thousand follow-ups are available for each of the fragments for expansion. In combination with structure-based design methods like docking, promising fragment extensions are now very fast accessible.