Furanocoumarins , 5-mercapto-1,2,4-triazole derivatives , quercitin, quercitrin and salanin , Pyridoacridines , Abemaciclib , Magnoflorine have been validated and their therapeutic efficacy have been confirmed in-vitro and in-vivo models. The computational methods are advantageous over conventional approaches for drug discovery as they are cost effective and less time consuming. Owing to the advantage of computational tools, the aim of present work is to search plant-based phytochemical molecules which can efficiently interact with the targeted proteins responsible for the development and progression of breast cancer using molecular docking studies. We have screened 1064 phytochemical molecules from plant sources against 5 potential hotspot targets: EGFR kinase domain, Human estrogen receptor alpha ligandbinding domain, FRB fragment of mTOR, Progesterone receptor and NUDT5 of breast cancer.