Thin Film Hydration Method was used to prepare the drug loaded Curcumin nanoparticles. In this method lipids such as Lipid Phosphatidylcholine and cholesterol, Curcumin which is the active ingredient and organic solvents such as Methanol and Chloroform are used. The lipid component and Curcumin are dissolved in the mixture of Methanol and Chloroform, by this step homogeneity and even distribution of the Curcumin within the lipid matrix is ensured. The use of organic solvents ensures better solubility of lipids and Curcumin leading to better encapsulation efficiency and chloroform used is an effective solvent for thin-film formation, but it does require careful handling to avoid residual solvents to end up in the final product.