The upregulation of glycosylation machinery increases the processing of RSV glycoproteins, an overall beneficial response for the virus. Responses downstream of XBP1 splicing are not able to explain the inhibitory effect associated with IRE1 activation, and instead RIDD is the likely mechanism behind this inhibition . While the regulated decay of host ER-targeted mRNA could be considered beneficial to the virus, RSV mRNA is unable to escape being degraded, which ultimately serves to inhibit viral replication.