The Circumsporozoites are densely coated by one protein (CSP) of 397 amino acids, accounting for 5-15 % of Plasmodium proteins. In the P.falciparum (reference 3D7 isolate), the CSP amino acid sequence contains an N-terminal signal peptide (SP) removed shortly after synthesis , followed by the 3D-disordered repeat (~ 45 % of the total sequence), and ended by the C-terminal domain (Table ). The 3D disordered repeats form a dynamical ~ shield-coat flanked by ordered N-and C-terminal domains. The 3D-disordered repeats extend the 129-273 residues , starting with a junction ( 101 NPDP + 3x 105 NANPNVDP repeats), followed by 35x NANP repeats with one 197 NVDP insertion 24 (Supplementary Materials / 5CSP-alphafoldmodels.pse, NANPmodelmimics.mp4, NANPmodelrolling.mp4). The C-terminal domain contains a glycosyl-phosphatidylinositol (GPI) membrane anchor, followed by a cell adhesive thrombospondin repeat (TSR) and one terminal α-helix.