One crucial assumption that is made is that a particular family of targets that is identified, includes all potential members of that family in the number of possible combinations. Since the pathway diagram describes a particular process or processes, the RDF can also be used to see if two targets are part of the same pathway and if they are part of the same process then the combination could be potentially synergistic. The If there is a directed interaction between the targets and the drugs share a common interaction stream, then they are selected and are sent to be evaluated for synergy.