To further understand the physics underlying hydrophobicity and the robustness of the nanoscale hydrophobicity metrics, we expanded our study to consider also some structural and stereochemical variations of polymer surfaces (Figs. ). Fig. illustrates strong correlation amongst all three hydrophobicity metrics despite their origination from different calculation methods and the inclusion of these surface variants. Consistently, PVA and PVA † are ranked as the most hydrophilic surfaces, while PTFE and PE are found to be highly hydrophobic. The intermediate placement of PVC, PMMA, and N66 is also robustly identified, although β μex w (N w ) does not offer a clear distinction amongst them. It is interesting to note that N66 * and PVA † are also consistently placed with respect to the amorphous PMMA, N66, and PVC for all three metrics. Together, these results suggest that the simulations capture key physical interactions that dictate wettability, and these interactions are reflected by computed nanoscale hydrophobicity metrics.