The self-driven reaction condition optimization platform consists of three modules, including an automated synthesis equipment (Unchained Labs, Big Kahuna), a HPLC (Thermo Fisher Scientific Vanquish), and a six-axis robotic arm (AUBO-i5) with a linear track. Big Kahuna automated experimental procedures, incorporating several components, including an extended tip liquid dispenser (20-3000 μL) for liquid transferring, the vortexing stations (60-3750 RPM) for mixing the reaction mixture, and a vial/plate gripper for transferring reaction vials and plates. HPLC analyzed reaction mixtures using a C18 reverse-phase column, with water and MeCN as the mobile phases. The robotic arm was responsible for transferring samples between Big Kahuna and HPLC. This hardware platform was controlled via a customized LabVIEW software, and experimental procedures and parameters were defined by the JSON method files.