For each experiment, we simulated 15 lipid combinations, 5 pure and 10 binary mixtures of the five lipid types at high concentrations (~220mM) to facilitate fast accretion. Each run lasted 50ns, and consisted of 54 monomers randomly distributed in the simulation box, surrounded with explicit water molecules. The lipids spontaneously self-assembled into clusters, which grew bigger over time (Figure ). As observed before two paths for cluster growth were present. While monomers are available in the environment (mostly during the first few nanoseconds), growth is driven primarily by stepwise addition of single-monomers to existing small clusters. However, after monomers are practically depleted, the lipid clusters continued to grow mostly through fusion events, exhibiting much slower kinetics. Notably, general monomer depletion occurred as even the concentration of single monomers in the simulation box is similar to their CMC .