Tripterygium wilfordii commonly known as 'Thunder God Vine' is a fascinating and potent medicinal plant with a long history of traditional use in various Asian cultures, particularly in Chinese herbal medicine . Some of the active principles of this plant have captured the interest of modern medicine due to their ability to modulate immune responses and inhibit inflammatory pathways, making it a subject of research for autoimmune diseases and inflammatory disorders . Hence, this species has been extensively studied, as evidenced by the 746 unique entries in this WikiData query (this additional query recovers the individual reports of each compound with the references). To further validate the general workflow used for the Celastraceae set, the annotations obtained based on the MN in PI mode for the extract of T. wilfordii roots and bark were assessed in detail.