While popular libraries like RDKit can handle fragment assembly, they lack dedicated workflows for this purpose. Some libraries are adept at the assembly of new molecules from smaller components, such as the widely used Python-based Stk or the Julia-based MolecularGraph.jl . Especially Stk stands as a prominent example as its primary objective is to offer a comprehensive API for fragment-based assembly. However, its focus lies in material sciences, offering a powerful and generalizable but still somewhat domain-specific interface. Other Python libraries like mBuild cater to specific software ecosystems like MoSDeF for molecular simulations. While tools like Pygen-Structures and Glycosylator excel in constructing molecules from specialized data formats (CHARMM files) or specific molecule classes (glycans), respectively. Although these tools provide valuable functions, they are typically specialized and not easily adaptable for tasks beyond their original scope.