When exposed to surfaces, the more hydrophobic surface (such as in PBS-DLS copolymer) hinders enzyme adhesion to the polymer film, decelerating the biodegradation process compared to the more hydrophilic surface (PBS-DLS-PEG). Subsequently, once enzyme molecules are absorbed on solid substrates, hydrolysis of ester groups by water is facilitated, catalyzed by the catalytic enzyme domains, leading to a more rapid biodegradation rate, particularly in polymers containing PEG. The incorporation of 5 wt.% PEG into the structure is responsible for the hydrophilic properties , promoting increased accessibility of the lipase enzyme to the surface, facilitating the hydrolysis of ester bonds in the polymer matrix. Notably, similar strategies have been employed on PBS-based copolymers containing PEG-like subunits, where lipase was utilized to study its hydrophobic interactions with the polymer substrate. As the result, a higher rate of biodegradability was obtained in copolymers with more hydrophilic surface .