Coronavirus 2019 (COVID-19) is a disease caused by the SARS-CoV-2 virus. The SARS-CoV-2 genome is a single-strand positivesense RNA , and its replication is facilitated through a multi-subunit replication/transcription complex of viral non-structural proteins (NSPs) . The key aspect of the NSP complex is an RNAdependent RNA polymerase (RdRp; NSP 12) 1, 5-6 . The RdRp requires extra factors, such as NSP7 and NSP8, for its activity . The active site of NSP12 is situated in the middle of the substrate domain, where the synthesis of RNA takes place as an RNA template is accessed from the template input channel. A structural representation of NSP7, NSP8, and NSP12 is shown in Fig. . The central RdRp domain is divided into three subdomains: the thumb, palm, and right-handed cup-like fingers. The relevant finger and thumb regions which constitute the open/closed structure of the RdRp protein are highlighted in Fig. . Due to the central role of RdRp in the replication process of viruses and its conserved structure, it is an attractive target for drug development against SARS-CoV-2 infections.