Paper has unique properties that are particularly useful for affordable sensing platforms. The advantage of paper as a sensor substrate is due to its high surface-to-volume ratio, porous structure, and small volume, which leads to faster analysis times compared to other methods. Blood sample processing, for example, can be done within 16 minutes using paper devices, compared to other methods that may require up to 1 hour or overnight. Portable enzyme-linked immunosorbent assays (ELISAs) using paper substrates can provide results in around 40 minutes, while traditional methods can take more than 3 hours per assay. In addition to faster analysis times, paper is also significantly cheaper than other microfluidic substrates, such as poly(ethylene terephthalate) and glass. The cost of paper is only 0.1 cents per square decimeter, which is 200 times less expensive than poly(ethylene terephthalate) and 1,000 times less expensive than glass. These advantages make paper an attractive choice for point-of-care testing, food safety, and environmental monitoring applications. Paper substrates can be integrated with analytical and clinical chemistry techniques to provide rapid and accurate diagnosis of diseases, including noncommunicable and communicable diseases such as cardiovascular disease, cancer, diabetes, chronic lung disease, and malaria. Paper sensors can also be used for environmental monitoring and food safety testing. Their versatility and affordability make them a promising tool for improving healthcare and addressing global health challenges. , , - In this review, we will delve into the exciting world of paper-based biosensors for detecting biomarkers in blood, with a particular focus on detecting albumins. With the increasing need for simple, affordable, and accessible diagnostic tools, paper-based biosensors have emerged as a promising solution. These biosensors are low-cost, easy to fabricate, and offer high sensitivity and selectivity. They can detect a wide range of biomolecules, including proteins, enzymes, nucleic acids, and antibodies, making them ideal for applications such as disease diagnosis, drug discovery, and environmental monitoring. By utilizing the unique properties of paper, such as its porosity, wettability, and capillary action, researchers have been able to create various types of biosensors, including lateral flow assays, microfluidic paper-based analytical devices (μPADs), and electrochemical paper-based sensors. These biosensors have been successfully used to detect biomarkers in blood for various diseases, such as cancer, infectious diseases, and cardiovascular diseases. We will explore the latest developments in paper-based biosensors, including the use of novel materials and fabrication techniques, as well as their potential for point-of-care testing in resource-limited settings.