Among the existing methods capable of intensifying biocatalytic processes in an efficient way, the coupling of enzymes with membrane technology in enzyme-membrane-reactors (EMR) is emerging as highly potent. Such integrated systems, simultaneously combining biocatalytic reactions and membrane operations, allow for more productive flow processes displaying enhanced product yield (by increasing the conversion and/or the selectivity of the process, via e.g. membrane-assisted product separation) and boosted enzyme kinetics (by preventing enzyme inhibition via controlled reagent introduction). Through this account, we aim at providing the recent trends and examples of the use of EMR for the intensified production of high-value chemicals, and in particular active pharmaceutical ingredients. Among the reviewed EMR configurations, we notably turn our attention towards membrane-immobilized enzymatic reactors. We argue that the implementation of such novel hybrid reactors which simultaneously host the immobilized enzymes and perform in-situ product separation, will catalyze further advances in the field of greener fine chemicals and pharmaceuticals manufacturing.