CIME is an extension of the ProjectionPathExplorer by Hinterreither et al . The front-end of the application is a website written in TypeScript, and it uses the React framework . Although the ProjectionPathExplorer web-application is standalone by default, providing all CIME-related features requires a back-end. We therefore developed a server-side Python application that uses the bottle framework [43] and can be accessed via a web-API (Application Programming Interface). Since chemists are familiar with Structure Data Format (SDF) files, and the format provides a clear structure of additional (atom-level) properties, we use them to define datasets of chemical compounds. The front-end, however, can only handle files in table format. The back-end is used to convert the provided SDF into the format required for the web application.