Using Equation and the test data from MNSol and FreeSolv, we calculated reference transfer free energies Δ𝐺 𝑡𝑟𝑎𝑛𝑠 (𝑎𝑞 → 𝑛𝑜𝑛𝑎𝑞) for 313 systems, where a system consists of a solute, an aqueous solvent and a nonaqueous solvent. Each set of free energies was simulated with Parsley 1.3.0, Sage, and GAFF 2.11 in order to provide comparisons to other widely used small molecule force fields. In each case, TIP3P is used as the water model for the solvent phase in aqueous mixtures and partial charges were assigned with the AM1-BCC method. For clarity, we will refer to the resulting GAFF force field as GAFF 2.11/AM1-BCC. While the recommended charge model for GAFF 2.11 is RESP, and others have indicated that GAFF 2.11/RESP often offers more accurate predictions than GAFF 2.11/AM1-BCC, we find that AM1-BCC charges are a reasonable charge model with significantly lower computational expense than RESP for large data sets. We also note that a new AM1-BCC-like charge model for GAFF 2.11, ABCG2, was recently developed; this charge model may offer improved performance on this benchmark set, but is not yet publicly available.