It is worth noting that Sunitinib has been reported to be effective for COVID-19 treatment, although not necessarily through inhibition of the main protease. For more information, see the statement "suggesting sunitinib is likely to be an inhibitor for dangerous coronaviruses infection with broad spectrum" from the paper . The top-ranked molecule from the QFVinardo docking results is Phenazopyridine, although approximately a dozen other drugs are within 1 kcal/mol of its estimated binding free energy at the top of the QFVinardo list. This case is particularly interesting because QFVina, using the same QM conformations, did not identify Phenazopyridine within its top 100 hits. This discrepancy highlights some differences in the intermolecular interaction assessments between the QFVina and QFVinardo scoring functions. It also illustrates that the field is highly competitive, where even small differences in scoring functions can completely remove top-ranked lead candidates from the hit list. This underscores the importance of every bit of accuracy improvement in docking, as even minor enhancements could lead to very significant improvements in the results.