The exact poses selected by Open-ComBind vary significantly when the generated, docked ligand poses are changed via different random seeds. However, on average Open-ComBind tends to improve pose selection in comparison to the gnina baseline. We see in Figures and? that the standard deviation for a given protein is often much larger than its mean, indicating the results of Open-ComBind pose selection are highly dependent on the poses of the ligands. Altering the random seed affects the poses in the top scoring 100 used for the pose selection process, which can affect the consensus pose found for the docking ligand and helper ligands. We do see that the average RMSD decreases in comparison to the baseline docking method, gnina, regardless of the random seed used (Figures ?? and ??).