Several LNP properties are optimized to improve their potency, such as particle and cargo stability in storage and/or blood, fusion efficacy in relation to endosomal escape, or even target-cell specificity . Regarding LNP stability, PEGylated lipids are often used to improve particle 'stealthiness' in terms of stability in the blood, and to help maintain a certain particle size while in storage . The main instability, however, has been identified as originating from the cargo, whether RNA or DNA . Given the extensive experimental data readily available on RNA degradation rates, AI-based approaches are already a reality for the computational design of new RNA sequences . However, the situation is different for LNP lipid composition and its influence on vaccine efficacy. Likely due to the lack of large, curated databases, there are currently no well-established AI-based protocols for optimizing lipid composition, despite its clear significance in enhancing LNP properties. Only initial attempts at in silico screening lipid compositions have been made .