ZAP-70 protein tyrosine kinase is a prognostic factor in B cell chronic lymphocytic leukemia (B-CLL). Its overexpression is related to the progress of the disease while aberrant phosphorylation of the protein is considered as a negative prognostic factor for the disease. The above spike-in experiments show that MIPs can recognize both the number and position of phosphate groups in the ZAP-70 kinase regulatory motif. Thus, the question was whether this ability, selectivity and specificity would prevail when exposed to protein extracts from cell lysates.