In addition, BA after an oral administration was calculated using equation ( ): BA% = (AUCpo/ Dosepo) / (AUCiv/Doseiv) × 100 (1) where subscripts iv and po denote intravenous and oral administration, respectively. Plasma concentration profiles of S-892216 in dogs and rats after a single intravenous administration of S-892216 anhydrous crystal at 0.1 mg/kg under the non-fasted condition are shown in Tables and (dogs) and Fig. (rats) and S3 (dogs).