The mildness and applicability of our visible-light photocatalytic hydroalkylation process was also demonstrated by the fact that several derivatives of biologically active molecules could be readily modified; this includes densely functionalized compounds, such as derivatives of sugars (i.e., -D-glucofuranose and -L-sorbofuranose), caffeine, cyclouridine and even a dipeptide (45-50, 43-69%). While alkyl bromides were not reactive under our original reaction conditions, we found that simple addition of NaI (2 equiv.) could obviate this issue by generating the corresponding alkyl iodide in situ via SN2. With this operationally facile approach, we could subject various primary alkyl bromides to the hydroalkylation strategy and obtain the targeted compounds in decent yields (12, 51-53, 44-50% yield).