Given the decline and even extinction of many coral species due to bleaching from global warming, genomic sequencing emerges as a vital method to preserve the valuable genetic resources within corals. By delving into the coral genome, we can fully leverage coral biosynthesis to discover more bioactive compounds through heterologous expression. Interestingly, despite the identification of several TSs from P. clavate in our study, no terpenoids have been reported among the documented inventory of secondary metabolites of P. clavata . This underscores the potential for significantly expanding the chemical diversity of marine invertebrates through bioinformatics mining and heterologous expression.