In order to assess overlaps and differences in results from different approaches, hinge binding fragments from literature are compared to fragments from the hinge-equivalent subpocket in this study, i.e. the AP subpocket building the AP subpocket pool. Xing et al. and Mukherjee et al. both report their 10 most common hinge scaffolds/fragments (Figure and Figure in the original publications, respectively). Excluding adenine and staurosporine from the comparison which were removed from this library (see ). While both reported methods check for hydrogen bonding between the fragment and the hinge region in crystal structures, KinFragLib is able to retrieve hinge-contacting fragments without specifically searching for hinge contacts but by checking the position within the binding site.