Since there is no cure for PD, drug repurposing studies have been intensely searching to identify existing drugs that could be repositioned to treat PD. As the pharmaceutical development process is both time-consuming and costly, drug repurposing provides a chance to accelerate it by exploring the PD-related effects of agents approved for other disorders. These drugs have established safety profiles, pharmacokinetic description, formulations, dosages, and manufacturing procedures. Recently, in silico pharmacology has been widely applied and various computer applications including machine learning and artificial intelligence approaches have been explored in identifying potential drugs for repurposing to PD. Drug repurposing has already been attempted in PD with various methodologies applied and several clinical trials are currently evaluating drug-repurposing candidates for PD. Exemplary drugs for PD repurposing are summarized in Table .