Lipophilicity has been a relevant physicochemical property in pharmaceutical research since the late 1800s, where the toxicity and anesthetic properties of several substances have been correlated to their solubilities in water and oil/water partition coefficients. In addition, this property has also been associated with several pharmacokinetic properties, such as enzyme binding 2 , toxicity , solubility , membrane permeability 5 , and bioaccumulation. Thus, lipophilicity has been considered a significant descriptor in drug discovery metrics, such as Lipinski's 7 and Veber's empirical rules, which are intended to optimize oral bioavailability for drug-like compounds. The partition coefficient (PN) describes the equilibrium of a molecule between the organic and aqueous phases, where the n-octanol/water system has historically been the medium of choice in pharmaceutical research because of its high correlation with biological activities. However, logPN only describes the equilibrium of molecules in their neutral states, which implies an unrealistic protonation state for most molecules with ionizable groups at physiological pH.