Open Force Field Open Force Field (OpenFF) parameters were used in 3 different versions (Parsley v1.0.0 21 and v1.2.1 and Sage v.2.0.0 51 ). The OpenFF toolkit 0.8.4 was used to parameterize the ligands with AM1BCC charges. In the following the three force fields are named OpenFF-1.0, OpenFF-1.2 and OpenFF-2.0, without the final patch number of the release.