Among human protein families, enzymes, in particular kinases, amassed the most variant data, though not always proportionate to the overall data volume. While these numbers do not correspond to evolutionary mutation rates , they are certainly correlated to the high interest in protein kinase variants in cancer research . Indeed, the targets that simultaneously displayed high variant bioactivity percentages and large amounts of data overall were predominantly cancer-related kinases with clinically relevant somatic substitutions such as EGFR , ABL1 , BRAF , and ALK . Nonetheless, in this category were also cancer-related kinases with no reported disease-related somatic substitutions like RPKS6B1 , where experimental mutations are common, or kinases responsible for other pathologies, such as LRRK2 in Parkinson's . Of note, the individual variants reported for specific targets also reflect the interest within the scientific community and do not necessarily include all reported and clinically relevant variants . Other than clinically relevant variants, experimentally important variants were found, such as activating substitutions in downstream cascades , or alanine scanning panels for functional , or thermostabilizing assessment in GPCRs. Far from negligible, such panels can be repurposed for model training, consequently reducing the need for experimental assays .