The development of synthetic molecular photoswitches has enabled great progress in applied chemistry allowing to control functions remotely with simple light irradiation with very high precision. Consequently, photoswitches are found in virtually every chemical field like chemical biology, materials research, catalysis, 9, 10 energy conversion, supramolecular chemistry, or molecular machines research. After decades of strongly committed developments, a large variety of synthetic photoswitches is available nowadays. The next big step for elevating utility is investigating their combinations to escalate the complexity of addressability, photoresponsiveness, and functions. A number of such photoswitch combinations achieved already impressive results being able to selectively and/or sequentially address the different states within a system. Despite this progress, truly orthogonal photoswitching remains to be extremely challenging at present, which makes it necessary to use secondary switching stimuli like electrical, thermal, or chemical signals in combination with light to achieve independent addressability.