However, such dependence could not hold here and, as a matter of fact, the presence of isolated polyhedral rule out the role of connectivity in the CD response. The origin of the increased asymmetry factor by moving from MBA to ClMBA could have various possible origins. On one hand, as reported above, the distortion index of the polyhedra increases when the halogenated cation is present, and this correlation between inorganic framework distortion and chiroptical properties has been established in chiral 2D lead perovskites. While the available data on chiral hybrid organic-inorganic copper halides is still scarce, some evidence on this direction start to accumulate, and this work adds further indications to corroborate this scenario. On the other hand, there is another evidence that it starts to become evident now that more and more chiral metal halides are synthesized and characterized, i.e. the impact of the CD response of the chiral ligand.