The most influential variables were FMF (a molecular framework ratio descriptor of the shape of the molecule), BalabanJ (Balaban's J graph index, which describes the molecular structure of small molecules), piPC (a path count descriptor of molecular topology), MWC and SRW04 (walk count descriptors, the latter of which relates to self-returning walks), VR (a normalised Randic-like eigenvector-based index derived from the Barysz matrix, weighted by atomic number), and VE (the average coefficients of the last eigenvectors of the Barysz matrix, weighted by van der Waals' volume). Detailed information about all molecular descriptors computed using MORDRED is available at descriptor.github.io/documentation/master/descriptors.html and in the book 3D QSAR in Drug Design. 39