In 3D, the database is organized in tranches of up to 5000 molecules each, organized by heavy atom count (HAC), lipophilicity (calculated logP), net molecular charge, and file format. This organization has the advantage that it allows the selection of molecules by these four features, and the molecules are grouped in work units that correspond to perhaps an hour of docking. For instance, it is easy to dock to lead-like cations, with 22 heavy atoms in db2 format, because the molecules are pre-packaged this way. The database is available from two clouds, as well as from our improved website, making the database easy to download. A tranche browser simplifies subsetting the database allowing the database screened to be tailored to the aims of each project. One billion molecules require about 1 TB for each of mol2, sdf, and pdbqt formats, while for db2 format the space required is around 200 TB (see Supporting Information S9).