Biocatalysts are based on natural proteins, enzymes, which can catalyze specific chemical reactions outside the living cells. Enzymatic biocatalysts are true green and sustainable catalysts. Produced from available renewable feedstocks (plants, animal tissues, bacteria, yeast, and fungi), they are organic, biodegradable, non-toxic and can function under mild reaction conditions (aqueous medium, pH ~7, normal temperature and pressure). Other advantages of biocatalysts include reduced number of byproducts and toxic waste. They also provide shorter and more selective synthetic pathways. All these benefits give a boost to the global biocatalyst market which is expected to reach 170 kilotons by 2026 if it continues to grow at a projected rate of In Figure , between 2012 and 2023, the number of journal publications on biocatalysts almost doubled. The rapid growth of biocatalyst patents from 2012 to 2014 was replaced by a slow climb up to 2021 with downs in 2018 and 2020. Although the fraction of patent documents makes up only a tenth of the total publication volume, the number of patents increased overall.