Through the use of classical simulations of oblate ellipsoidal fluid particles, this work provides a general analysis of how particle shape and interaction anisotropy influence the equilibrium orientation of a wide variety of isotropic liquids at interfaces with both a solid and vapour-like phase. For a range of parameters spanning a subset of organic semiconductor (OSC) space, different substrate types, and different thermodynamic conditions, we find remarkable universal scaling of interface orientation with a simple interfacial free energy parameter based on nearest-neighbour pair interactions and the interfacial entropy of purely repulsive particles of the same shape. Based on these results, we propose several practical methods for achieving the desired orientation at both interfaces, which we hope provide a pathway towards the rational design of high performing OSC-based devices.