We find no realistic use cases where the use of CP correction is disadvantageous. (CP correction can increase the convergence error when double-hybrid functionals are used with small Pople basis sets or with def2-SVP, but this reflects the inadequacy of those basis sets for MP2 correlation rather than a limitation of the CP procedure.) CP correction increases the cost of the calculation by a modest factor, typically ≈ 2.5×, even for large proteinligand complexes with hundreds of atoms, and is therefore feasible whenever the supramolecular calculation itself is feasible. CP correction can be used with double-ζ basis sets to obtain reliable results in large systems where triple-ζ calculations are intractable. We suggest that it use should be considered mandatory for supramolecular calculations of ∆E int in large systems, especially when only double-ζ calculations are computationally feasible, in order to ensure that the results do not suffer from error cancellation due to BSSE. Even with triple-ζ basis sets, CP correction can compensate for the absence of diffuse functions and furthermore provides a means to estimate how far the finite-basis value of ∆E int may be from the DFT/CBS limit.