Manually augmented RBFE networks used in previous studies for this series contain 30-40 edges. While it could be expected that increasing the number of edges present in the network would increases the accuracy of the results we find that this is not the case with the fully connected network (figure ). The RBFENN network also uses ejm_31 as a hub for scaffold hopping, but also introduces a second hub (ejm_42) as well. The latter perturbations exploit the pattern MCS-C-C→ MCS-C-Cycle.