Once a binding site is known, it is useful to understand all the possible ways in which a fragment can bind to that site. Experimental data, including crystal structures and binding affinities, are ensemble averages over all these possible configurations. However, in MD simulations, the kinetic barrier associated with changing binding mode can be very high making this process challenging to sample. If medicinal chemists do not fully understand how a fragment binds, crucial information on how to optimize or exploit certain binding interactions may be lost. Here, we explore the ability of GCNCMC to sample multiple binding modes without any prior knowledge of their existence.