[ Repeatedly, a stronger hydrophobic contrast resulted in lower drug loadings in this family of amphiphilic block copolymers, clearly stressing the point that the simplistic picture of a hydrophobic core, which dissolves hydrophobic drugs [6] , may often be inadequate. [12, 19-21] Since the drug loading (in wt.% vs. polymer) and final drug solubilization (in g/L) are critical parameters dictating, to a certain extent, the clinical potential of a formulation, a closer look at the interactions between polymeric drug carriers and solubilized drug has recently received attention. This includes a critical evaluation of the traditional core-shell concept as evident by the drug-induced morphology switch of POx based micelles from worm-like, to spherical and raspberry-like structures with increasing PTX-loading (0 -50 wt.%) [24, 25] . In contrast, the formation of a worm-like morphology was observed at high-loading (50 wt.%) of the same drug-carrier loaded with etoposide and a platinum (Pt)-based prodrug. It was recently confirmed by Callari et. al. using solid state nuclear magnetic resonance (NMR) and endocytosis studies , that the different morphologies can have direct impact on biological properties. Micelles at low-loading of a Pt-based drug had a rather loose structure, whereas the highloaded micelles were much more condensed with aggregated Ptspecies surrounded by a densely packed hydrophilic corona. The cellular uptake of these micelles, bearing fructose moieties in the hydrophilic corona, depended on fructose-specific cellular uptake transporters. Accordingly, endocytosis was significantly higher at lower loading due to the less-restricted interaction of the flexible polymer chains. In contrast, the apparently too densely packed fructose moieties at higher loading reduced the cellular uptake.