The electrochemical reduction of carbon dioxide (eCO2RR) using renewable electricity has emerged as a promising avenue to address anthropogenic CO2 emissions and combat the global energy crisis. Considering the cost of electricity and separation, and the potential value in downstream synthesis through Fisher-Tropsch chemistry, carbon monoxide (CO) is regarded as an economically viable choice among the potential eCO2RR products. However, the formidable activation barrier of the C=O bond in CO2, alongside the competitive hydrogen evolution reaction (HER), hinder its practical application. Hence, the quest for a catalyst displaying both suitable activity and selectivity becomes pivotal for the practical realization of CO2-to-CO conversion. potential applications. Consequently, substantial efforts have focused on reducing the free energy barriers for *COOH intermediates formation via regulating electronic configuration of highly structure-symmetric NiN4. The coordination environment engineering, such as altering the coordination numbers (NiNx, x<4), substituting N atoms with other heteroatoms (S or P ), or introducing axial coordination atoms (N, O 25 or Cl ), have been explored to break the planar symmetry of NiN4 and tune the electron distribution around Ni sites. Furthermore, incorporating functional groups or nanoparticles on the substrate can also adjust the electronic symmetry, by regulating the metal-substrate electronic conjugation, impacting the electronic polarization of NiN4. However, employing a sole strategy involving the distortion of electronic density or alteration of the d-band center is limited and inadequate, thereby diminishing the effectiveness of optimization for a low overpotential and a wide potential range. Thanks to the spatial and functional compatibility of each regulatory strategy, combining both approaches could effectively redistribute electronic configuration around the Ni centers at different hierarchical scope. More importantly, diverse strategies superimposed on the same active site will form additional electron tug effect, resulting in a unique electron distribution. This distortion of electronic structure could facilitate the adsorption and activation of reactive intermediates and achieve high CO2 reduction activity and selectivity.