At the same time, the pharmaceutical industry requires compounds in kilograms or even larger scales, so development of the methods suitable for implementation in flow reactors is the logical continuation of the synthetic evolution. To achieve high performance, switching from homogeneous to heterogeneous catalysis seems to be almost inevitable. In addition, the use of heterogeneous catalysts leads to the simplification of product purification from the contamination of the metal ions, facilitates reuse, and reduces e-factor (i.e., a quantity of waste and pollution of the environment) .