The performance of analogous Chemprop models trained and tested on RGD1 provide a useful reference (Fig. ). Similar to the EGAT architectures, the Chemprop model that eschews ∆H r information performs the worst on average, but only by ∼0.5 kcal/mol compared with the multitask Chemprop architecture (G→ ∆H r , Ea). The best EGAT architecture marginally outperforms the best Chemprop architecture in this comparison, but we do not consider this difference significant for reasons that are further explored below.