SCSIO F063 , while it was isolated earlier from the marine-derived fungi A. versicolor . Averantin-1′-butyl ether ( The same study revealed that from the two isolated brominated anthraquinones, only 78 displayed modest cytotoxicity against NCI-H460, SF-268, and MCF-7 cell lines with IC50 values of 18.91, 24.69, and 25.62 μM, respectively . Furthermore, another bioactive derivative of averantin ( ) isolated from Aspergillus sp. is 6,8,1'-tri-O-methylaverantin showed an anti-neuroinflammatory effect via different mechanisms including suppression of the overproduction of many pro-inflammatory mediators including COX-2, PGE2, and NO in lipopolysaccharide-activated BV2 microglial cells , (Figures and). Indeed, penicillanthranin A (81) and B (82) which are anthraquinone-citrinin derivatives, as well as chrysophanol and ω-hydroxyemodin , were isolated from the marine fungus P. citrinum PSU-F51 . Penicillanthranin A (81) and chrysophanol (83) exhibited selective antibacterial activity against the Gram-positive S. aureus ATCC25923 with MIC value of 16 μg/mL and MRSA SK1 with MIC value of 16 and 64 μg/mL, respectively , while both compounds 82 and 84 were not screened for their antimicrobial activity in the same study.