Experimentally, the measurement of octanol/water partition coefficients can be laborious. Tse and Sandler therefore investigated the ability to determine octanol/water partition coefficients indirectly by instead measuring values of the limiting activity coefficient of the solute in each phase; the log limiting activity coefficient and solvation free energy are directly related . Furthermore, just as it was desirable to avoid the direct measurement of P o * /w 1 , it was desirable to avoid measurements with water-saturated octanol and instead use only pure (neat) solvents: