The same Vapourtec system can be adapted for the defluorosilylation of HFO-1234yf, forming 3 successfully at room temperature (Figure ). This is the first example of applying flow methods to upgrade HFOs through synthesis. Optimal process conditions were found to be a 1.3 ml min -1 liquid flow-rate of a 110 mM solution of 1•THF1.5, 3.0 ml min -1 gas flow-rate of HCF3 at 1.4 bar leading to 62 % yield of 3 with a production rate of 5.3 mmol h -1 . The reaction proceeds selectively at room temperature, with just 1.2 equivalents of gas and a residence time of 2.5 minutes, compared to a 3 hour reaction time in batch. This reaction could also be effectively run for an extended period using crude 1•THF1.5 allowing removal of a purification step from the overall procedure. The flow methodology offers a marked increase in space-time yield of 1.05 mol l -1 h -1 , an 86-fold improvement compared to batch. CF2HSiMe3 has previously been demonstrated to be a versatile difluoromethylation agent, reacting with a range of electrophiles in the presence of a fluoride source (e.g. CsF) or base (e.g. KO t-Bu). Due to its lower volatility 2 might offer improved ease of handling and storage compared to CF2HSiMe3, however its applications in synthesis are limited to difluoromethylation of a range of aromatic and aliphatic aldehydes catalyzed by KF. To further expand the utility of this compound, we investigated reactions with a series of aromatic, a,b-unsaturated, and heteroaromatic aldehydes. Reactions were run at 25 °C using CsF as a catalyst. Once conversion to the silylated alcohols was complete, TBAF was added as a stoichiometric reagent to effect the complete desilylation of the products. Difluoromethylated alcohols 4a-f were prepared in modest to good yields (Figure ). The reaction tolerated furyl, pyridyl, benzothiothenyl, and pyrazolyl groups, along with halogens. An analogue of the key intermediate in the preparation of Telotristat Ethyl (a tryptophan hydroxylase inhibitor) in which the CF3 group has been substituted for a CF2H group could be prepared. Difluoromethane was observed as a minor by-product in certain cases, most likely arising from the desilylation of 2 with CsF. Compound 3 also proved an effective precursor to generate fluorinated propyne groups. Treatment of 3 with 1.5 equiv. of KHMDS in THF followed by addition of IPrCuCl (IPr = 1,3-bis(2,6-diisopropylphenyl)imidazol-2ylidene) and heating to 60 °C for 18 h resulted in the formation of the copper(I) acetylide complex 6 (Figure ). 6