The NP-likeness calculator (NPLC) was reported in the year 2012 and is an open source reimplementation of the well-known Ertl NP-likeness score created at Novartis in 2008. The NP-likeness score of Novartis was incorporated into several standard processes including virtual screening, selection of compound samples for purchasing, prioritizing hits from high-throughput screening (HTS), and library 2019 the proportion increased to 64.9%. The NP-likeness score of the individual Latin American countries is mostly positive (Fig. . A and A1).