A set of control compounds were collected for retrospective docking analysis . The compounds camostat, nafamostat, and benzamidine were selected as they possess pan-serine protease activity. The ligands from templates 5PAB and 4TY6 were also used as positive controls as they contain geometry of ligands likely to be active at TMPRSS2. For these 5 compounds, 50 decoys were generated with matching physico-chemical properties but scrambled topologies using the DUD-EZ pipeline. Model that could dock all active compound with high score were taken forward into the next round of optimization.