Furthermore, the selected docked compounds showed a higher hydrogen bond 0.8 than the control, which showed a hydrogen bond of 0.2. of arbutin has a value of 1.35. Hydrogen Bonds: (H-bonds) play a significant role in developing novel drug candidates because of their strong influence on drug specificity, metabolization and adsorption. Overall, it can be inferred from this study that compounds from Vaccinium vitis-idaea L. are relatively stable in the selective pocket of PDE6D compared to Sotorasib (control ligand).