The domain search method was employed to investigate the protein function of EBOV in this work. The results indicate that L, N, S, VP24, and VP35 have LCN type CS-α/β domains. S LCN type CS-α/β is a neurotoxin with a lengthy chain that can activate Na + channels. S protein is involved in virus entry into the cell. It can activate the Na + channel and Na + /K + pump in the extracellular area. Then it facilitates the injection of a significant amount of Na + into the cell function. The LCN type CS-α/β domains of VP24, VP35, and N are short-chain toxins that can inhibit voltage-dependent or Ca +2 -activated K + channels, as well as partially activate sodium channels. Both VP24 and VP25 contribute to the regulation of viral genome replication and transcription , as well as viral budding . N and L proteins play a direct role in the replication and transcription of viral genomes. So, N, L, VP24, and VP35 can regulate the intracellular region of the K + channel and Na + /K + pump and thus inhibit K+ ion output. 2. Related sequences. The 731 LCN type CS-α/β related sequence was downloaded from UniProt data set. Keywords is "LCN+CS-α_β".