Figure shows the distribution of success rates for each of the 6 runs. Run 1-3 are with the same parameters (parameter set 1 in Table ) and run 4-6 are with the same parameters (parameter set 2 in Table ). The parameter sets are almost identical, the only difference is that the first run in parameter set 2 is initiated with a smaller push strength. The total number of successes is quite similar within the 6 runs (ranging between 81 and 83 TS located) and the majority of the TSs are located using the guess structure from the RMSD-PP path directly. Combining all TSs located during the 6 runs, a total of 89 TSs are found. For the first parameter set (run 1-3) 85 TSs are located and for the second parameter set (run 4-6) 88 of the TSs are located. It is possible, that exploring a larger part of the parameter space allows localization of the last reactions.