The PVDF-based UF membranes M1 and M2 demonstrate comparable separation performances and good antifouling properties (16-22% FR and ~99% FRR). Comparative LCA using the ReCiPe midpoint and endpoint methods shows that M1 exhibits less environmental impact than M2 in every category. The greater impact of M2 compared to that of M1 is due to the larger consumption of electricity and toxic solvents during its fabrication and modification.