As highlighted in this review, there is a complex relationship between THC and the D1 receptor. The modulation of D1 receptors by THC has significant implications for understanding the cognitive and behavioral effects of cannabis. In particular, in the context of increasing cannabis use following its legalization in various regions around the world, it is essential to understand the diverse array of cognitive and behavioral changes associated with THC use and what molecular mechanisms mediate this. As discussed, research on D1 receptor-mediated effects of THC are particularly lacking.