In order to incorporate bond information into the atom pair embedding, we design an atom-bond interaction network (ABIN) to improve the molecular representation by reinforcing message interactions between atoms and bonds in the graph, as shown in Fig. . Various MPNN methods have been proposed in learning molecular graph representation, and our ABIN module is inspired by the previous CMPNN (Communicative Message Passing Neural Network) method , which is a variant of MPNN architecture to improve molecular embedding by strengthening the message interactions between nodes and edges through a communicative kernel.