Because of the large divergence of amino acid sequences, it remains to be proven whether similar conformers could be generated for the R4-TrD interfaces on other rhabdoviruses, such as mammalian VSV, rabies or Chandipura or fish VHSV isolates, IHNV or SVCV. As indicated by some preliminary results, one of the key steps, would be to find sequence-specific appropriated parent 2D molecules to start successful co-evolutions.