We computed the hydration free energies for a set of 42 small molecules, 37 previously employed to evaluate AMOEBA's performance and the recently introduced ANI/AMOEBA model. This set covers common chemistry examples, including benzene, acetic acid, and ethane. The experimental values are sourced from the Guthrie solvation database. In our experiments, the FF parameters for the solvated molecules are taken from either the original GAFF or GB-FFs models, while the surrounding water molecules are modeled using the TIP3P water model, 81 bonds and angles are constrained using the rattle algorithm. The calculations were performed using the newly introduced λ-ABF method within Tinker-HP, over a total of 10 ns of simulation time in the NPT ensemble with the Berendsen Barostat and the velocity Verlet integrator. Based on the original paper describing the The overall performance is depicted in Figure , and the comprehensive data details are documented in Tables and.