The method tolerates the presence of Ar-Br groups, which could be useful for further functionalization. Substrates derived from ibuprofen and flurbiprofen delivered the products 2p-q with good competence. Pendant benzyl groups and alkenes were similarly tolerated (2r-s). A single diastereomer of products 2j-2s was isolated. The quaternary carbon of the azetidine can present two different aryls (2t). Substrates with a secondary C(sp 3 )-H did not afford 2, possibly owing to their higher BDE (limitations in SI). We Substituted C(sp 3 )-H groups could be functionalized, leading to the formation of the b-lactams in up to good yield and with moderate diastereocontrol (3J-O). The series included bulky cyclohexyl fragments and poly-substituted aryls, such as those derived from two commercial drugs. The presence of an aryl substituent on the key C(sp 3 )-H group is not necessary (3P). The functionalization of a secondary C(sp 3 )-H group, which had a relatively higher BDE, 14 occurred diastereoselectively (3Q). The spirocycle 22 3R was prepared, showing that the method can be applied to amino-acid derivatives. Finally, disubstituted allenes could be employed (3S).