Having successfully decorated one of the morpholine rings and deprotected the resulting product, ready for a second decoration step, we used the KNIME analytics platform 49 to enumerate a virtual library of 630 compounds, from which 124 diverse 50 compounds were selected for physical synthesis (see Supporting Information). Compounds were chosen to occupy drug-like chemical space, obeying Lipinski's rule of five and Veber's rules. Twelve singly decorated scaffolds were synthesized from Boc carbamate 10 in yields ranging between 66-98% over the two steps; urea 14, which had been synthesized in sufficient quantity from Cbz carbamate 12, provided a further singly decorated scaffold. These 13 singly decorated scaffolds were then applied in amidation, sulfonylation, urea formation and reductive amination reactions, on 60-80 mg scale, to assemble a library of 124 compounds (see Supporting Information). The products were purified by HPLC.