Co-crystallization enables the optimization of the pharmacokinetic properties of active pharmaceutical ingredients (APIs) . Via co-crystallization, supramolecular interactions between the API and another molecule (coformer) Institute for Complex Molecular Systems, Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands. Department of Chemistry and NIS Centre, University of Torino, Torino, Italy. Centre for Living Technologies, Alliance TU/e, WUR, UU, UMC Utrecht, Utrecht, The Netherlands. Research and Early Development, Dompé Farmaceutici S.p.A, L'Aquila, Italy. Correspondence to: F. Grisoni <f.grisoni@tue.nl>.