Most of the F13L1 (green) and F13L2 (red) children from DWBEL and ADV predicted higher affinities than the initial Tecovirimat-parent (Figure green and red solid circles, respectively). However, because of their very different algorithms for calculations and targeted cavity/grid identifications, the DWBEL docking-scores did not exactly correlated with ADV affinities (Figure , green and red).