• Initial studies in animal models have shown the inverse vaccine can completely reverse autoimmune attacks in diseases like multiple sclerosis and type 1 diabetes. • Early phase I safety trials have been conducted in people with celiac disease, and further trials are underway for multiple sclerosis. • Researchers are exploring the use of this new inverse vaccine approach for other autoimmune conditions like autoimmune inflammatory rheumatic disease such as rheumatoid arthritis and systemic lupus erythematosus as well.