This process was repeated 25 times with a different randomly generated lead peptide for each sequence-based strategy and peptide lengths (8-to 11-mers). To ensure a fair comparison, the same lead peptide were reused for each sequencebased strategy. Additionally, the sequence-based strategies were compared to a random search: five different batches of 96 peptides, corresponding to the total number of DMT cycles, were randomly generated. This random search was also repeated 25 times in total.