Among the various methods given by Literature Scouter (Fig. ), we continued to query which method had the greatest potential for practical applications. Literature Scouter recommended the recently developed copper/TEMPO dual catalytic system developed by Stahl group as this method outpaced others in the aspects of the environmental sustainability, simplicity, safety, chemoselectivity, and substrate compatibility (Fig. ). After manually evaluating other recommended methods, this copper/TEMPO catalytic chemistry indeed avoids the use of heterogeneous catalysts , high-cost palladium catalysts , or light irradiation used in other approaches, proving to have claimed potentials in practical applications as suggested by the Literature Scouter. In addition, the chemoselective oxidation of the target hydroxyl group in diols or polyols is attractive in practice as function group protection and deprotection would not be required, reducing the number of steps required to synthesize the target compound. The literature Scouter recognized the capability of copper/TEMPO catalytic system was able to selectively oxidize primary alcohols in presence of the secondary alcohols on the same molecule (Fig. ). Having identified the target transformation, we next turned to extract the detailed reaction conditions for this catalytic system. The literature document was provided to Literature Scouter to summarize the detailed experimental procedures and options for various reagents and catalysts. This information served as the basis for the subsequent experimental exploration of this chemistry (Fig. ).