Compound ODR is known to be a moderate binder of the BRD4(I) protein with an affinity of 4.8 µM The initial structure of the complex was obtained form the 3svg PDB file. We used the GAFF2 force field for the two macrocycles and the ligand ODR. Assignment and AM1-BCC 50 charge calculations were done using the PrimaDORAC web interface. The BRD4 protein was modeled using the AMBER99SB-ildn force field.