KinFragLib, which is introduced here, takes advantage of the large amount of structural data on kinase ligands from KLIFS for subpocket-based fragmentation and recombination (Figure ). Organizing fragments from kinase ligands by subpocket allows not only to perform a detailed subpocket-specific analysis of their fragment space, but also to better understand the composition and spatial arrangement of reported kinase-ligand complexes. Moreover, this kinase-focused fragment library organized by subpocket allows for a specific and controlled fragment recombination, unveiling a completely unexplored territory in the chemical space of kinase inhibitors.