Many applications of approximate sTDDFT have to deal with three important practical limitations: (i) the neglect of environmental response contributions and couplings between active-system and environment response; (ii) the use of an approximate NAKE functional, which has consequences both in terms of the associated NAKP affecting orbitals and orbital energies, and in terms of the (non-additive) kinetic kernel contributions entering the coupling matrix; and (iii) the use of monomer basis sets, which are usually chosen for reasons of efficiency. While issue (i) can in principle be addressed in terms of the hierarchy discussed above, the practical success may be intertwined with the strategies to tackle the other two problems: If a monomer basis set is employed, no inter-subsystem charge-transfer excitations can be described by construction, since the orbital product space is simply not flexible enough to allow "outgoing" charge-transfer excitations. But a supermolecular basis set is usually also not suitable, since the virtual orbitals localized in the environment will, in general, have an incorrect structure due to the deficiencies of the NAKPs (see the discussion below).