We have portrayed the use of the SBMOpenMM library in a study of the protein folding of a small-protein system, from the conformational sampling to the calculation of the free-energy surface and its kinetic hierarchization using a Markov state model analysis. SBMs can serve as an initial step before moving into simulations employing state-of-the-art MD force fields following adaptive sampling techniques to study complex biomolecular phenomena. In such approaches, relevant conformations, carefully extracted from the simplified simulation, can be used as seeds to optimize the phase-space sampling by more costly simulations, making SBM a relevant and practical tool to conduct complex theoretical research in protein biophysics.