One approach to addressing the challenges highlighted is by combining electronics with cells in vitro by to self-assembled electronics in situ in 3D. Self-assembly of 3D electronics has previously been shown using a range of materials, and electrochemical techniques. To merge such techniques with biology, a wireless approach is desirable, which is possible using bipolar electrochemistry. Bipolar, or wireless, electrochemistry has been used previously to grow microwires (MWs) in the absence of biological systems. We have previously shown wireless MW growth in the presence of cells (2D monolayers) which is possible using micro-bipolar electrodes (BPEs) stimulated under direct current (DC). There have been no other reports of merging this method with 3D systems. Whilst previous studies have utilised electrochemistry to grow MWs to interface with individual cells, none have yet to utilise this method with mammalian cells or to develop novel therapeutics/electroceuticals.