Enzymes have traditionally been essential in constructing glucose sensors due to their recognized method of processing glucose, which forms the chemical principle of such a sensor. Biological enzymes exhibit swift reactions with glucose because of their catalytic activity and making the direct oxidation of glucose an advantageous process. GOx is extensively utilized among the enzyme families involved in glucose metabolism . In principle, GOx based sensors operate by facilitating the enzymatic oxidation of glucose, resulting in the production of gluconic acid and H2O2 (Fig. ) through the following reaction: