Our dGNN methodology and high-throughput database of vacancy predictions can be used to rapidly screen candidate materials in other important clean energy applications. The reverse water gas shift-chemical looping (RWGS-CL) approach operates in a concept very similar to STCH. H 2 gas is used to reduce a metal oxide, after which oxidation with CO 2 produces CO for downstream hydrogenation to carbon-based fuels. Like STCH, the process is driven by thermodynamics of oxygen vacancy formation. Ref. 47 strongly correlated the energetics of vacancy formation to other computed properties like O 2 surface-adsorbate binding energy to conclude, "It is thus best said that E vac can solely describe the RWGS-CL process and is capable of predicting the CO 2 conversion ability of perovskite oxides." Based on a previously known CO 2 -splitting perovskite (La 0.75 Sr 0.25 FeO 3 ) for which they computed an average oxygen vacancy formation enthalpy of 3.4 eV, they concluded that candidate materials with similar thermodynamics (e.g., ∆ ĤO d ∈ [3.0, 4.0] eV) would be highly active. This was confirmed by synthesizing new perovskites with the desired vacancy thermodynamics and measuring their outstanding activity. By this metric, one can readily use our model to identify optimal candidates for RWGS-CL. Similar to our STCH screening, we "re-discover" experimentally known CO 2 -splitting oxides, e.g., the La 2 MnCoO 6 system. , while discovering new ones (Figure ). Oxygen vacancy formation enthalpy has also been corre-573 lated with the critical performance metrics for perovskite ox-574 ide cathodes in solid oxide fuel cells. Ref. 48 discovered 575 a simple linear relationship for SOFC perovskite cathodes be-576 tween ∆ ĤO d and a metric for the macroscale oxygen-transfer 577 performance, the area-specific resistance (ASR). The authors 578 noted that successful materials should approximately be tar-579 geted with ASR ∈ [0.02 Ω cm 2 , 0.24 Ω cm 2 ], or between the ASR 580 values in the optimized Ba 0.5 Sr 0.5 Co 0.75 Fe 0.25 O 3-δ (BSCF) and 581 La 0.625 Sr 0.375 Co 0.25 Fe 0.75 O 3-δ (LSCF) systems, respectively. This 582 essentially represents the trade-off between the correlated stabil-583 ity (high defect formation enthalpy) and low operating temper-584 ature (low defect formation enthalpy). Using