In addition, the most remarkable inhibition against the activity of AChE was observed by 7 with a nanomolar IC50 value (Fig. ). To visualize the potential interactions of 7 with AChE, docking studies were conducted. As illustrated in Fig. , the hydroxyl groups on the A and B rings and TEM studies indicated shorter and thinner fibrils with less branching by adding 7 with metal-free Ab42 than those of compound-untreated metal-free Ab42. The morphological changes of Cu(II)-Ab42 and Zn(II)-Ab42 aggregates were also prominent upon treatment of 7, exhibiting chopped fibrils and a mixture of amorphous and fibrillary aggregates, respectively. These reactivities of 7