During the last few years, RNA-protein complex simulations have started to appear in the literature (for example, . While this field is starting to gain interest, it is unfortunate to see that there are only a few studies published which use multiple force fields in studying RNA-protein complexes . The selection of force field and other simulation parameters depends on the studied system , and thus some time should be spent testing suitable options for each study case. One could assume that polarizability of a force field could help in simulations containing RNA, as strong electrostatic interactions are in dominant role in these systems and one of the problems why it has been difficult to develop parameters for nucleic acids in the point-charge force fields . However, polarizable force fields are computationally demanding and thus a few orders or magnitude slower than the traditional force fields. In this study, we wanted to find if there are differences between traditional non-polarizable point-charge force fields and a polarizable force field when describing the RNA-protein complex interactions. A new polarizable water model for non-polarizable force fields was published during the preparation of this manuscript, and it was also included to illustrate a compromise between the extremes.