Finding TSs for testing possible mechanisms (typically suggested by experimental chemists) is an important part of computational chemistry. While many promising methods for automating this process have been proposed in the last couple of decades , much work regarding finding TSs is still done manually. For a non-screening application like this one, where a mechanism is proposed and a handful of TSs need to be found, there would likely be some degree of manual adjustment/evaluation. Numerous computational studies have demonstrated this kind of work for the MBH mechanism . The TS-structures for the TMA catalytic cycle (steps highlighted with a full green arrow in Figure ) are also found manually here. The full reaction profile, with the proton transfer from intermediate 166 to intermediate 446 conducted by methanol, is shown in Figure . The energies and barriers for equivalent steps using DABCO as the catalyst are shown for comparison. As expected, TMA is calculated to be a worse catalyst than DABCO. With a calculated activation energy 1.3 kcal/mol higher than DABCO, the reaction catalyzed by TMA is expected to be roughly 9 times slower. The catalyst templates chosen need to be rather generic in order to reduce the number of templates to be investigated by growing their reaction networks. Therefore, we generally do not expect to find good catalysts among the templates. Rather, we hope to find a starting point for further optimization.