The current reach of these methods is documented by run times and scaling of hybrid DFT simulations for several challenging materials, including hybrid organic/inorganic perovskites and organic crystals, with up to 30,000 atoms (50,000 electron pairs) in the simulation cell. Despite such large systems sizes, the simulations can be run with moderate computational resources. per self-consistent field iteration. The HSE06 hybrid functional was used for all simulations. The following systems were simulated (from left to right): phenylethylammonium lead iodide (PEPI) with a defect complex , a 4x4x4 paracetamol supercell, a 15,288-atoms Ice XI supercell (inlcuding a force evaluation), and a 30,576-atoms Ice XI supercell. All calculations were carried out on the Raven HPC cluster at the MPCDF using Intel Xeon IceLake (Platinum 8360Y) nodes with 72 cores per node.