Experimental studies into MOF activation have provided several rules of thumb for successful solvent activation, providing indicators of the underlying phenomena controlling activation-collapse. Lower 65 surface tension and more volatile solvents such as acetone, dichloromethane, and hexane are recommended over higher surface tension, less volatile alternatives (Table , Table ). In terms of the framework components, overly long and rigid linkers are discouraged, as they may enable larger solvent phases to form with greater associated capillary stress. Similarly, twisted or flexibile linkers can lead to mechanical torsion in the metal-ligand bonds, thereby reducing the capillary stress 70 required to break metal-ligand bonds. These rules of thumb are largely founded on the theory that vaporisation of the solvent forms a vapor-75 liquid interface within the MOF, and that the associated surface tension creates capillary stresses on the framework which are strong enough to mechanically destroy the material. This theory of capillary stress-led collapse has been corroborated by the successes of activation procedures avoiding the liquid-gas phase transition through the use of sublimation or supercritical fluids. However, to our knowledge these driving forces have yet to be confirmed theoretically and absence 80 of theoretical insight prevents the generation of deeper understanding of key solvent and framework features driving activation-collapse. Furthermore, development of models to describe MOF activation would enable computational prediction of new activation protocols, reducing experimental overhead during materials discovery.