To understand the relevance of accessing to QM data for solvated molecules, we first discuss the influence of implicit water 9/16 on extensive and intensive molecular QM properties. In doing so, as an illustrative example, we have analyzed the 2D property space defined by two contrasting properties such as the isotropic molecular polarizability α and the HOMO-LUMO gap E gap (i.e., α, E gap -space) for the 59, 783 conformations in AQM-gas and AQM-sol as well as the set of most stable conformer per molecule in AQM-sol (only 1, 653 conformations), see Fig. (a). For comparison, the values corresponding to QM7-X equilibrium molecules are also plotted (green circles). Our findings reveal that AQM molecules exhibit a significantly broader coverage of the α range, surpassing QM7-X molecules by a factor of 6. This expanded coverage is attributed to the inherently extensive character of α. Whereas, E gap range now covers molecules with circa 2.5 eV of energy gap, and the mean value for the entire dataset reduced from 7.0 eV to 4.5 eV, see distribution plots on the top panel of Fig. (a). These alterations in the coverage of α, E gap -space resulted in a change of the absolute Pearson correlation factor |ρ| between these properties, which increased from 0.06 in QM7-X (weakly correlated) to 0.65 in AQM-gas (moderately correlated) . While AQM-gas molecules may appear to occupy a larger region in α, E gap -space, we found that AQM-sol molecules exhibit the same |ρ| within this property space. This result may be attributed to compensation between the pronounced fluctuations in α, which are predominantly observed in molecules with α > 300 a 3 0 , and the more sensitive behavior of E gap to the presence of implicit water, as displayed in the correlation plots in Fig. (b). Accordingly, these findings could carry crucial implications in the "freedom of design" when searching for large drug-like molecules with targeted α, E gap values . Notice that the conformational sampling per molecule largely improved the coverage of both properties, connecting isolated regions associated with a single molecular structure with specific size and chemical composition. Fig. (b) also shows the correlation plots between HOMO energy E HOMO and total dipole moment D s of the 59, 783 conformers contained in AQM-gas and AQM-sol. Thus, it becomes evident that intensive properties are more sensitive to the incorporation of molecule-solvent interactions in the QM calculations when contrasted with extensive properties.