Spontaneous Raman spectra of powder raw materials and prepared films with 0% and 100% drug loading were collected with a confocal Raman microscope (NT-MDT Ntegra Spectra, Russia) equipped with a 532 nm laser and 100x objec ve (Mitutoyo, Japan). The spectral range covered was from 300 to 3500 cm -1 with a resolu on of approximately 10 cm -1 determined by measuring the full width of half maximum of the Raman peak of silicon at 520.7 cm -1 . Powdered samples were placed on a microscope slide for the measurement, while the films were measured directly on the cover glasses they were prepared on. Laser power on the sample was 10 mW and the acquisi on me was adjusted from 1 to 6 s depending on signal strength.