In later work conducted in one of our groups , it could be shown that this is not due to a deficiency in the approximate embedding potential, but to the neglect of the coupled response between the organic molecule and the solvent; if the environmental response is properly taken into account, the qualitatively correct behavior is recovered even with approximate NAKPs and monomer basis sets. The study by Niemeyer et al. also introduced a damped-response implementation of subsystem TDDFT suited for the computation of electronic absorption and ECD spectra, which can also be employed within the context of projection-based subsystem TDDFT. An example application is shown in Figure : For cluster of ibuprofen solvated by 20 ethanol molecules, this figure contains data for the specific rotation as a function of the wavelength for the entire system, the isolated ibuprofen and environment systems, as well as data that illustrate the coupled response of the environment only and the uncoupled environment effect on the ibuprofen molecule. The subsystem TDDFT data are in very good agreement with the supersystem results, both for the case of one combined environment system [FDEc (comb. env.)] and for the treatment of separate molecules as separate subsystems . From the timings it can be seen that in particular the last case offers significant computational savings, since only 10 % and 22 % of the wall-clock time are needed for the ground-state and response part of the calculation, respectively. Another illustration of the efficiency of this implementation is provided for a snapshot of methyloxirane solvated by 15 benzene molecules in Ref. 12, for which a fully response-coupled subsystem calculation considering each molecule as a separate fragment only takes about 8 % of the computational time needed in a supermolecular calculation. Jensen and co-workers developed a linearresponse generalization of their polarizable FDE method , which made use of atomic polarizabilities based on Hirshfeld partitioning and is suited to reproduce coupled polarizabilities.