For each EDA computation, we compared the DFT energies against AmberFD, as well as three force field models: AMBER99 with Chen and Garcia modifications, Drude-2017 nucleic acid force field (CHARMM), and AMOEBA multipole force field with parameters from Zhang et al . The OpenMM simulation library was used for both AMBER99 and Drude force fields while the Tinker 2022 was used for the AMOEBA force field computations. The code used to perform AmberFD EDA computations can be found at it's GitHub repository. Additionally, all PDB ID's and the residues used in these computations can be found in the Supporting Information.