the most frequent epigenetic targets with 18 compounds each, followed by LSD1 with eight compounds, BET/BRD4 with four compounds, and DNMT3a, DNMT3b, HAT/Ep300, KDM4a, with activity vs. two compounds in any case. Furthermore, three epigenetic targets are associated with specific reported activity vs. only one compound each: HDAC1 with phenethyl isothiocyanate (PEITC), SIRT1 with pterostilbene, and SIRT 5 with glutamate. The five compounds identified in the search with activity vs. the largest number of epigenetic targets were: biotin (27 targets), berberine (15 targets), alpha-ketoglutarate (13 targets), trichostatin (12 targets), and butein (11 targets). These and additional compounds are shown in Figure , including the chemical structure and the number of targets in parenthesis.