Herein, we demonstrate for the first time a practical cross-coupling strategy between (hetero)aryl bromides and gaseous alkanes through a combination of hydrogen atom transfer photocatalysis and nickel catalysis. The use of flow technology was pivotal in offering precise control over reaction conditions, facilitating easy reaction optimization, rapid scope expansion, and seamless scalability. DFT studies enabled us to understand the origins of unique experimental observations, pinpointing the oxidative addition as the rate-and selectivitydetermining step. Furthermore, this integrated approach provides a framework for future developments in utilizing gaseous alkanes as reaction partners in various coupling reactions.