The extreme complexity of interactions amongst factors and pathways implicated in the process of aging, looking for pharmacological strategies targeting aging is certainly a very difficult task. Still, substantial progress has been made in this research field recently. Significant anti-aging capacity has been revealed in some natural compounds as well as in certain classes of chemically synthesized substances. These include calorie restriction mimetics such as metformin, rapamycin, and resveratrol. Using several model organisms, such as yeast, worms, flies, and rodents, these potential drugs have been reported to extend life expectancy by up to 25%-30%. Great expectations are currently related to the development of senolytics -drugs that can selectively eliminate senescent cells. Another hopeful class of pharmacological agents involve substances targeting the epigenetic control of gene expression such as histone deacetylase inhibitors, including sodium butyrate, suberoylanilide hydroxamic acid, and trichostatin A. Another strategy of searching for anti-aging agents involves assessing the health spanpromoting ability of drugs that have been already approved by the regulatory authorities to treat certain chronic pathological conditions. These include common medications such as aspirin, metformin, melatonin, certain statins, vitamins, and antioxidants. A benefit of repurposing such drugs is that their long-term safety has been repeatedly examined and approved, their possible side effects have been well known through various clinical trials and examinations. Evidence has been accumulated that such common drugs may indeed enhance health and well-being in elderly individuals suffering from a variety of age-related chronic pathologies. The collection of currently explored anti-aging agents is dominated by natural compoundseither pure substances or extracts. Vital nutrients such as certain vitamins, minerals (as micronutrients), amino acids, polyunsaturated fatty acids, probiotics, and plant metabolites, such as polyphenols and terpenoids, are recognized for their ability to prevent aging and promote healthy aging. Natural antiaging sources are present in a wide variety of foods including meat, fish, poultry, fruits, vegetables, herbs, cereals, nuts, grains, legumes, dairy products, cocoa/chocolate, as well as in beverages such as juice, tea, coffee, and wine. Natural extracts from plants and herbs such as green tea, turmeric, yerba mate, thyme, licorice, mulberry, and grape are also known for their anti-aging, mainly antioxidant potencies. 556-560