The medicinal applications of ruthenium complexes holding carbohydrate functionalized ligands was the focus of numerous studies . Different carbohydrate units, various coordination modes, as well as presence/absence of protecting groups were experimented (Figure ). For example, Ru(II)arene complexes as D (Figure ) with carbohydrate-derived phosphorus-containing ligands, have demonstrated promising antiproliferative activity and selectivity in vitro , with cytotoxicity dependent on the lipophilicity. Half-sandwich Ru(II) derivative E , bearing a mannose fragment as a diaminobidentate leg ligand, and complex F[78,79], with a galactose fragment N-coordinated via a nitrile group, exhibited promising antiproliferative activity on various cancer cells.