(Right) Ligand fragmentation with assigned subpockets and dummy atoms (grey). FP) to gain potency, followed by their neighboring subpockets, such as GA targeted to gain selectivity. In this dataset, the remote back pocket is targeted less frequently due to two reasons: First, the 69% of the underlying kinase structures show the αC-in conformation, limiting the available space for ligands in B1 and B2. Second, 73% of the front cleft binder, whereas only 25% of the back cleft binders target the αC-in conformation. Pool X contains 285 additional fragments, i.e. these fragments were classified as lying outside of the main binding site or showing not allowed subpocket connections.