The example in Figure illustrates the process used in Rule 4b for VS262. Note that branches change order, depending upon the reference. In this case, some of the branch orderings have already been set, due to a Rule 4a comparison, r vs. ns. The reading of the S-ranked ligand A, SRSRRR (read from centers 1-6, in order), is encoded as 101000 in base-2, giving a value of 40.