Compounds 1 and 2 were tested in vitro against HepG2, a hepatocellular carcinoma cell line for liver toxicity. Upon compound addition and incubation over 72 hours, compounds 1 and 2 displayed very low levels of activity with EC50 values of 55.83 µM and 60.29 µM respectively, whereas pan-kinase inhibitor staurosporine was highly active with an EC50 of 0.09 µM (Figure ).