However, applying Chodera's method to the individual runs for the bound vanish stages re- veals substantial variability of the times discarded, generally ranging from no data discarded to nearly all data removed. This is concerning because we care about removing systematic bias in our ensemble result, where the bias results from a relaxation process shared by all runs. We expect this to have a comparable timescale between runs, and therefore replicates should have similar equilibration times. It appears that explicitly using information about the inter-run reproducibility of the transient in the paired t method increases robustness.