Biological thiols, such as glutathione (GSH), cysteine (Cys), and homocysteine (Hcy), are essential for preserving the proper redox state of biological processes. GSH, a tripeptide of glutamate, cysteine, and glycine, is the main nonprotein thiol in living cells. For healthy individuals, cellular concentrations of GSH range from 0.5 to 10 mM, and its concentrations in physiological fluids are approximately 2 to 12 µM . GSH has several important cellular functions related to metabolism, antioxidant defense, regulation of intracellular redox status, protein glutathionylation, as well as mitochondrial function and integrity . Abnormal concentration levels of GSH are associated to various diseases including oxidative stress resulting in cancer , neurotoxicity , heart problems 5 , Alzheimer's , aging related deseases .