A selection of tablets across the 47 to 548 MPa range of compaction pressures were subject to analysis and their composition maps created. We have limited the discussion to the side profile of the tablet, shown in Figure , however, similar observations are found for the front-facing direction. The reconstructed images of the tablets (Figure ) clearly show the spatial distribution of the phases, where normalised glycolide Form I distribution is represented by a jet colour scheme. The diffraction patterns indicate that, of the known forms of cellulose, the MCC present can be identified as Cellulose I. Cellulose I can be split into two crystallographically independent phases, Iα and Iβ; polymorph Iβ is the more thermodynamically stable form. Figure shows the XRD-CT images showing distribution of Form I and II for tablets compressed at different pressures. If we focus on the low pressure image of, 47 MPa, it shows that the components of the tablet are homogeneously mixed together with an even distribution of the Glycolide Form I in the bulk MCC. MCC appears to remain unaffected and its distribution is consistently maintained across all pressures (see SI for maps of MCC) which supports previous observations hence the discussion will focus on the transformations in glycolide (Figure ).