Figure shows a visual representation of the chemical multiverse of NAPROC-13, immersed in the chemical multiverse of the known NPs (using COCONUT as an approach to this set), and compared with the chemical multiverse of a set of NPs designed to be diverse, as is UNPD-A, and the FDA-approved drugs. According to physicochemical properties related to pharmacological interest, NAPROC-13 comprises a region of the chemical space shorter than UNPD-A, and both of them cover a limited region of NP chemical space. FDA-approved drugs overlap a considerable zone of NPs' chemical space as has been demonstrated in previous analyses (see Figure .A). According to their structural motifs, the coverage of the chemical space of NPs included in NAPROC-13 was approached using the molecular fingerprint ECFP4, broadly used in the representation of NPs in previous studies, and classically recognized as adaptable and functional for the correct representations of both small and synthetical molecules, as well as big molecules and of natural sources. The structural diversity of NPs present in NAPROC-13 determined by using this methodology, saving the character of UNPD-A of being a diversity-focused library as mentioned above, is highly remarkable (see Figure .B). middle of the graphical representation, in contrast to natural products, that covered a broader region of the structural features. This trend appears to be reproduced in terms of drug-like properties, where UNPD-A reflects a wider region of NP chemical space than NAPROC-13.