The pool of nucleobases comprised adenine, uracil, cytosine, thymine, and xanthine. Besides the nature of the nucleobase, other structural features of the conjugates were evaluated, i.e., the type of linker between the two moieties. As anchoring nucleobase (purine, pyrimidine) entities is expected to boost the antiparasitic activity of the respective hybrids with the diruthenium unit, conjugates with other types of small molecules were also synthesized and evaluated to ascertain this approach.