Given the thermal instability of tertiary carbamates, we hypothesized that a similar strategy could be used to template pairs of amines within framework pores (Fig. ). Amines are ideal entry points to more complex structures thanks to their rich postsynthetic chemistry. They have been shown to undergo a multitude of reactions within MOF pores, including imine formation, urea formation, alkylation, and acylation. In principle, it should be possible to convert templated amine pairs into diverse site-isolated bimetallic sites via established postsynthetic ligand modification and metalation steps.