Studying the marine-derived fungi has been started around two centuries ago when the first fungal species, Sphaeria posidoniae (Halotthia posidoniae) was reported on a rhizome of the marine grass Posidonia oceanica in 1846 . Marine fungi have been isolated from different habitats including algae, mobile, and sessile invertebrates, sediments, marine mammals, and driftwood from different marine locations . Despite the importance of marine fungi as a promising source for novel bioactive secondary metabolites, marine fungi are still less investigated sources for natural products discovery programmes compared to other niches of fungi . Although the estimated number of fungal species on the earth is ranging from 1.5 to 5 million species, only around 1100 species have been exclusively isolated from the marine niche .