Here we introduce a novel hySAS method for proteins and nucleic acids where we use a singlebead (1B) representation to describe the scattering behaviour of an amino acid, and a three-bead (3B) mapping for a nucleotide, one for the phosphate group, one for the pentose sugar and one for the nitrogenous base. This choice allow us to achieve better performance and to alleviate a source of inaccuracy in the Martini representation, specifically the need to extrapolate the bead form factor when it assumes negative values . Importantly, to include the solvent layer contribution for small 𝑞 values, we reformulate the SBA 𝐹(𝑞) as the sum of three form factors: