The anti-malarial activity of chalcone was first reported after an in-vitro assessment of an oxygenated chalcone, "licochalcone A," derived from Chinese licorice, as an antimalarial drug against chloroquine sensitive and chloroquine resistant Plasmodium strains, . In addition, a large number of possible licochalcone A analogues with various patterns of substitution have been identified as having powerful anti-malarial action. Several chemists have been drawn to the straightforward design and clear synthesis of chalcones in their quest to develop novel analogues of this peculiar framework for treating numerous infectious illnesses, including malaria .