-To include a measure of synthesizability which is practically needed in any real-world drug discovery campaign, we additionally score molecules by running the RAscore pre-trained models and compute the arithmetic mean of this score together with the predicted probability of 5-HT2A activity as before. Da. Each molecules property value is transformed into the range 0-1 (see Figure ) and combined by arithmetic mean with the predicted probability of 5-HT2A activity as before.