On the other hand, each of the three OH groups per RsvH3 molecule can donate a hydrogen atom among the dynamic behavior in an extensive HB network formed in solution, where the alternation of HB formation and breaking between RsvH3 and oxidants such as the ROS is provoked. As demonstrated in a computational study by Cristina et al. on the reactions of RsvH3, the OH in the para-position of the stilbene moiety (4'OH) is the most reactive due to the resonance effects compared to the other two meta-OH groups (3OH and 5OH). In their pioneering work, antioxidant activity of RsvH3 toward HO2 • and HO • as substantial cellular toxins in the living body were investigated, because of their high reactivity than that toward O2 •-.