The RMSD and RMSF values of the KRAS(G12C) protein (Figures ), display comparable behavior observed in other SII-P binder all-atom MD simulation studies of the microsecond timescale . GDC-6036 displays generally stable binding in the SII-P site in the simulations, but in two individual replicas instability was observed based on the higher peaks in the ligand RMSD values (Figure ). The highest ligand fluctuations were observed in the flexible 1methylpyrrolidine motif, based on the RMSF values (Figure ). This data supports that the overall simulation is valid for the putative GDC-6036 binding mode and interaction analysis.