The two principle curvatures, κ 1 and κ 2 , can exhibit both positive and negative values depending on the local curvatures at a given point on the droplet surface. Therefore, the mean of these values (as in the mean curvature) may not comprehensively represent the intrinsic curvature behavior in numerous instances. To this end, we employed a new descriptor namely, squared curvedness, which is κ 2 1 +κ 2 2 , which intrinsically possesses a positive value. This provides a relative depiction of the nan-odroplet surface curvature within a w/t/o nanodroplet, as compared to the pure w/o system. The interplay between tbp and the water droplet prompts an increase in the cumulative surface curvedness of the droplet. Notably, the presence of the amphiphile tbp enhanced the surface curvedness by ∼ 1.57 × compared to a pure water droplet within 10 ns (Figure ).