Other neuroglial cells, such as oligodendrocytes and NG2 glia, may also contribute to ALS and HD pathology. Oligodendrocyte dysfunction can disrupt myelination and impair neuronal signaling, contributing to cognitive and motor impairments. NG2 glia, also known as oligodendrocyte progenitor cells, respond to injury and participate in remyelination processes. Dysregulation of these neuroglial cell types may exacerbate neuronal dysfunction and degeneration in ALS and HD.