About 13% of samples in AL 2 (blue) had vesicles, the average total concentration in AL 2 was about 7.5 mM. To focus attention on lower concentrations in AL 3, the input concentration maxima were reduced by half, and still, 92% of AL 3 samples (pink) had vesicles! The total concentration bounds were limited to less than 1 mM for every amphiphile in in AL 4 , but none of these samples contained vesicles (green). Hence, in AL 5 (yellow), a decision was made to revert the input space bounds to the same as in AL 3. Although the GPC model had been updated based on the new data, the results were similar to AL 3, and 94% samples had vesicles. This suggested that finding vesicles was relatively easy in this range of concentrations.