This work demonstrates the ability of SPIONs to induce in situ amorphization in tablets intended for oral administration. Upon exposure to an AMF, elevated temperatures were achieved in SPION-containing tablets, leading to high amorphization and improved in vitro dissolution. The degree of amorphization was strongly linked to the maximum tablet temperature, which depended significantly on the SPION composition, SPION content and the drug load. Complete amorphization and high apparent solubility were achieved in tablets with 20 wt% Mn0.5Fe2.5O4 and 30 wt% celecoxib after 15 minutes of AMF exposure. Furthermore, unlike laser and microwaveinduced amorphization, these tablets are homogenously exposed to the AMF and use safer excipients that are less likely to cause drug degradation. The in situ amorphization can be finetuned according to the obtained DoE model and the method can be widely applied to ASDs with other polymer-drug compositions. The use of a biocompatible excipient produced by a scalable synthesis technique, along with the high drug load in ASDs produced by in situ amorphization, make the developed method a promising tool for broader use of ASDs as enabling formulations in oral drug delivery.