Table : SurA and GAK binding pocket properties computed with SiteMap: DScore, druggability score (values of 1.0 or greater are generally considered druggable); 37 hydrophobic, hydrophilic, hydrophobic, and hydrophilic character of the site, respectively (a value of 1.0 represents the average for tight-binding sites); The selected binding pocket of SurA was smaller than the GAK pocket (363 vs. 507 Å 3 , Table 1) and displayed a high hydrophobicity (hydrophobic 1.52, Table ). Furthermore, the binding site features more hydrogen bond donors than acceptors (donor acceptor ratio 1.25, Table ). The GAK target was, on the other hand, more hydrophilic (hydrophilic 1.02, Table ) and had a higher proportion of acceptors in the binding pocket (donor acceptor ratio 0.91, Table ).