However, Shigemi tubes are costlier than regular 5 mm tubes. Further, for each solvent-type one Shigemi tube is needed demanding procurement of many tubes for the different type of solvents. One cost-effective way to avoid deuterated solvents is the No D NMR, which is used for monitoring of reactions and determining the concentration of reagents. However, this method does not increase sensitivity, so the running cost due to spectrometer time is still there. Busy organic chemistry labs may need substantial amounts of NMR solvents annually, and CDCl3 is used most widely in sample preparation. More expensive deuterated solvents-D2O, DMSO-d6, acetone-d6, methanol-d4, DCM-d2, THF-d8 are also used which raise the cost. Therefore, it is important to enhance the sensitivity of NMR and reduce or eliminate deuterated solvents and particularly using 5 mm o.d. tubes which are in widespread use in organic synthesis labs.