In order to reach these goals, we need to create results that stay relevant beyond the task at hand. Good quality data is a gift that keeps on giving, bad data will continue to mislead and is dif cult to identify. We arrived at a standardized work ow which we continuously optimize, also to maximize throughput. We recognize that standardization comes with compromises and we accept them. As part of the standardization, we aim to use solid-dosing and a standard LCMS-method as much as possible. Precision will suffer for the former when aiming below one milligram target amount and, for the latter, peak shape or separation may not always be ideal. Reactions are run at a scale between one to ve milligrams of limiting starting material in the presence of an internal standard and twenty to one hundred microliters of solvent. They are mostly conducted in one milliliter vials as part of ninety six or twenty four well plates. We perform liquid dosing using electronic pipettes and each reaction mixture is sampled manually at several time/temperature points.