Procedures for hemin-tyramine (H-Tyra) conjugation: This was performed according to Okorochenkov et al., 2012, with some modifications. To solid hemin (100 mg, 0.154 mmol., 1.0 eq.), DMSO (3 mL) was added under nitrogen atmosphere with stirring for 1 hour at room temperature with the exclusion of light. To this solution, EDC (147.6 mg, 0.77 mmol., 5.0 eq.) and NHS (44.4 mg, 0.386 mmol., 2.5 eq.) were added. The mixture was stirred further under nitrogen atmosphere for one hour at room temperature, then tyramine (84.6 mg, 0.616 mmol, 4 eq.) was added with stirring for a further 24 hours under the same conditions as described previously. The final product was precipitated by its addition to a saturated NaCl solution (6 mL), followed by the addition of diethyl ether (24 mL), mixing and vacuum filtration. The precipitates were washed several times by ether. This was followed by two time-washing by double distilled water to remove the precipitated NaCl crystals giving a dark brown solid with some greenish precipitates. After its drying, the solid was dissolved in methanol (100 %) and filtrated. The final hemin conjugate was purified using a sephadex G-15 column and methanol (100 %) as the mobile phase, which was finally removed in vacuo. The final blackish-brown powder was characterized by HPLC, UV-vis, 1 H-NMR, FTIR, and ESI-MS.