In the context of the study of nucleation processes from solution, metadynamics has been applied to explore the configurational landscapes associated with the nucleation of small organic molecules from liquid solutions , the nucleation of salts from aqueous solution , the nucleation of methane clathrates , and the assembly of perovskites . Figure Adapted from Ref. . C) Metadynamics enables the discovery of a two-step nucleation mechanism for the synthesis of Methylammonium Lead Iodide Perovskites from solution. Adapted from Ref .