The CACHE #2 competition targeting SARS-CoV-2 Nsp13 was initiated with applications due in September 2022. As specified in the CACHE roadmap 2 , an independent applications review committee (Table ) selected 25 participants for CACHE #2, based on the results of a double-blind peer review process where each applicant evaluates and rates five randomly selected applications. Twenty three out of the 25 selected teams submitted their computational predictions within the specified two-month timeframe.