Several experimental studies and few computational studies considered Mn-porphyrin catalysts and Mn-salen catalysts to carry out C-H halogenation, in particular, C-H fluorination . Manganese-catalyzed oxidative benzylic C-H fluorination was shown to be accomplished with better yields using Mn-salen catalysts . Mn-porphyrin complexes were found to catalyze selective aliphatic C-H bond halogenations with remarkable yields for a certain range of organic substrates . However, our attempts to fluorinate drug-like molecules (e.g., containing heterocycles with N or O atoms) under the same experimental conditions were excluded. The reasons for this inapplicability of the published procedures of synthesis to drug-like molecules, as far as we know, are unclear.