It can be argued that increasing the number of predictions beyond the top 50 templates, will increase the number of predicted templates that encode ring formations which can be applied. However, it is clear from Figure and the previous explanation, that in the case of the standard model applied to the substrates in Figure , this would have to be extended to at least the top 150 predictions. This extension would enable at least one template that has been recorded as a ring formation in the reaction data to be applied. When the standard model is considered as part of the tree search algorithm which searches for and selects synthetic routes, rather than as a standalone model, this serves to increase the search breadth of the subsequent tree search. To this end, the computational expense associated with enumerating the tree to this extent must be balance between the speed of prediction and the number of retrosynthetic options the model suggests. In the case of the prediction of ring formations, Ring Breaker balances both these criteria by predicting ring forming reactions with both a lower rank and * lowest rank: 133 higher number of applicable predictions in the top 50, as compared to the standard model or its subsequent filtering.