We supplemented the PCA analysis displayed in Figure by separating each subgroup and labeling by features of interest (Porod exponent or Rg). In contrast to PDB proteins which displayed greater Porod exponent throughout, the copolymer backbones and conjugates contained distinct pockets of lower flexibility regions indicative of higher order that even differed between each synthetic subgroup (Figure ). This implies that it would be nearly impossible to logically formulate a de novo framework for designing similarly structured compact copolymers.