The 2022 workshop was a hybrid event with 31 in-person participants at the EBI, and 44 members participating via Zoom. The first day began with general overviews of progress and workshop plans by each working group plus an update by Juan Antonio Vizcaíno on the current state of the ProteomeXchange Consortium. After a short break, the Molecular Interactions Working Group split off into a separate track while the Mass Spectrometry, Proteome Informatics, and Quality Control Working Groups continued in a joint session to briefly discuss all of the topics relevant to all three working groups since there is substantial overlap in interests between the members of these groups. The second day was devoted to substantial progress on mzSpecLib and mzQC (both discussed further below) in parallel tracks, whilst the MI group focused on format implementation and data curation. The third day began with more parallel track development and ended with a final plenary session with summaries of progress in each of the parallel tracks. The individual track sessions typically involve minimal presentation and mostly discussion of unresolved items that need group input, general planning, and development and assignment of action items.