For all 43 DUDE-Z targets, the normalized LogAUC (also called "enrichment score" 50 ) of annotated ligands over property-matched decoys produced by the default DockOpt configuration was found to be better than that produced by the unoptimized, human-made DOCK parameterization included for that target in DUDE-Z 48 (Figure ), whose parameters are the same as the default parameters of our previous protocol .