This accounts for difference in time that the feed stream needs to reach the reboiler between the real case and the simulation. In scenario IIa, the feed stream reaches the reboiler before the reboiler mixture is at boiling temperature, whereas in scenario IIb, the feed stream reaches the reboiler right, when the reboiler mixture is at boiling temperature. In contrast to the simulation study, in scenario IV, the feed is introduced, when the reboiler is at a temperature of A Shimadzu Nexis GC-2030 gas chromatograph (GC) connected to an autosampler/-injector is used to analyze the composition of the samples taken from the pilot column. Detailed parameters for the GC analysis method can be found in the supplementary material. The samples are diluted with acetone in a sample to solvent ratio smaller than 1.