Our results were somewhat unexpected because of the parameterization focus of Martini in reproducing hydrophobic/hydrophilic preferences. Had this selectivity been correct, the experimental dimerization interfaces should have been recovered, at least in Martini 2. However, the issue of protein over-aggregation in Martini 2 stems from excessive particle densities and an associated imbalance of effective molecular hydrophobicities/hydrophilicities . Martini 2's failure to recover the coiled coil polarity matching could be, at least in part, a consequence of such a specific imbalance.