In the view of the industry collaborators performing this benchmarking work, this study evidences the advances made by the Open Force Field Initiative towards its objective of building high quality open force fields produced with infrastructure which enables rapid parameterization. Particularly, the series of OpenFF force fields tested in this study showed significant enhancement in accuracy over a relatively short time, and these improved force field are publicly available. Pursuing the road to progress, one key challenge will be represented by continuing improving the treatment of problematic areas of chemical space and expanding coverage. Forthcoming OpenFF updates are planned to include Wiberg bond order-based parameter interpolation to improve the treatment of torsions, off-site charges and optimized handling of trivalent nitrogen geometries (which should boost performances further). Additionally, a tool for fitting bespoke torsion parameters for specific molecules/chemistries of interest is now available likely further improving accuracy. In parallel, a biopolymer force field and an OpenFF software stack that will enable the conversion from OpenMM objects to file formats understood by other molecular simulation engines, like AMBER and GROMACS (OpenFF Interchange 71 ), will soon be released.