A well-studied additive manufacturing (AM) method for the preparation of fiber mats with high surface area is solution electrospinning. With this method fibers mats with poorly controllable fiber placement, but low fiber diameter can be prepared. However, usually the use of (toxic) solvents is necessary. To avoid the use of solvents, melt electrospinning can be an alternative to produce fiber mats with poorly controllable fiber placement. With both techniques, drug loaded fiber mats were prepared with drug release varying form several minutes to month, depending on the polymer matrix and drug used. Another AM technique for the preparation of ASDs with high drug loading is melt electrowriting (MEW), which allows accurate microfiber placement on a computer controlled moving collector. The fiber diameters achieved by using this technique are usually ranging from 5 to ~50 µm with the possibility of producing unique and highly defined printing patterns. The printed fiber mats have a high surface area which can result in fast dissolution. Previously, drug loaded scaffolds were prepared with drug release varying from minutes to several hours. The longer drug release was achieved by using poly(ε-caprolactone) as polymer matrix , whereas shorter drug release times with dissolution of the whole scaffold were observed by using an amphiphilic ABA triblock copolymer comprising poly(2-oxazine) (POzi) and poly(2-oxazoline) (POx). Here, high drug loading and dissolution within 1 -5 min depending on the drug loading was achieved. However, the due to the low glass transition temperature (Tg) of the polymer, the sample preparation needed additional hot melt extrusion for sufficient mixing of polymer and drug.