The similarity in the amino acids involved in the Hydrophobic interactions which are short The chemical GRL0617 is 5-Amino-2-methyl-N-[(1R)-1-(1-naphthalenyl)ethyl]benzamide and is known to inhibit the papainlike protease that is present in SARS CoV . This protease is a potential target for antiviral compounds . We found the SARS-CoV-2 has homology with this and the binding sites for this in the structural protein of the SARS-CoV-2 is the same (Table ). This compound inhibits the enzyme that is required for the cleavage of the viral protein from the virus in SARS CoV, it also cleaves ubiquitin and has a structural homology with the Deubiquitinases (DUBs) of the Ubiquitin-Specific Proteases