To start with, the projection view was used to determine which areas of the parameter space have previously been explored, and the yield predictions (mean and standard deviation) from the latest model were displayed using the hex bins (T1), as shown in Figure . Three ligands were identified that had a high uncertainty in yield prediction as no experiments had been performed in these areas; therefore, the chemists all selected to run at least one experiment using one of these unexplored ligands, for example, in one case JackiePhos was selected.