Out of 1369 non-lysosomotropic compounds present in the combined training set and time-split set, 682 of them were also tested at higher compound concentrations of either 30µM and 50µM in the CPA in addition to the standard 10µM compound concentration. While approximately 40% of such compounds (277 compounds) show lysosomotropism at higher concentration, the remaining 405 compounds remain non-lysosomotropic. Moreover, out of these 405 compounds which stay non-lysosomotropic at both standard and higher concentrations, 255 of them are bioactive (induction >5).