There are few investigations of the nonspecic interaction between excipients and APRs as a mechanism of aggregation prevention that considers all areas of the protein The initial united-atom structure is simulated for 10 ns in water at pH 7.0 and indexed so that each index group of atoms corresponds to a MARTINI bead. The angles and distances between these beads are measured and used as the bonded parameters in the MARTINI topology, a frame is extracted and used as the initial structure for a MARTINI simulation,