Notably, the SAR of D37 and D38 suggests that A. baumannii is more sensitive to the modification of position 6, particularly when the residue is changed from the positively charged side-chain of L-lysine or L-arginine. This could hint at more pathogen-specific interactions or other factors affecting the antibacterial potency of darobactins. indicates the L -cysteine adduct) and ordered depending on their antibacterial bioactivity against A. baumannii DSM-30008, based on a MIC assay using crude extracts (Table ). "≈" comparable activity; ">" or "»" higher activity.