In our prior research, we took the initial step of creating a predictive multiphase detailed chemical kinetic model for polymer fouling in an industrial distillation column that separates C4 and lighter species from heavier ones ("debutanizer"), as illustrated in Fig. . That model only considered the base case scenario, which includes alkanes, alkenes, conjugated dienes, and aromatics from steam cracker effluents, and excluded any impurities or industrial additives. The model showed that under the base case scenario, the main fouling mechanism is the polymerization of reactive monomers, e.g., dienes. Moreover, the model illustrated that under the base case scenario, fouling growth is primarily caused by reactions in the thin film on the tray surface, while reactions in the bulk liquid are crucial for controlling the concentration of reactive intermediates (e.g., radicals) involved in the surface reactions.