Over the last decade, BRDs have emerged as a ligandable class of protein modules that are therapeutically relevant. Despite this, the TRIM proteins remain amongst the most understudied BRD-containing targets. Ligands for the BRD of TRIM24, which also bind to the BRD of BRPF1, have been reported by both Palmer et al. and Bennett et al. In addition, a PROTAC for TRIM24 was developed and confirmed TRIM24 as a novel dependency in acute leukemia. In a recent patent, multiple ligands were disclosed for an unspecified TRIM33 isoform; 51 there are no non-peptide ligands reported for the PHDs of TRIM24 or TRIM33.