The aforementioned reactions all rely on Ni-catalysis to facilitate productive C-C bond formation. However, the use of sulfonyl hydrazides is not limited to Ni as exemplified in Table with the direct trifluoromethylation of these species (36-42) using Grushin's commercial Cu-based reagent , Cu(bpy)(CF3)3 (easily prepared on gram scale from TMSCF3 and CuI). Unlike the related trifluoromethylation of alkyl halides or alcohols with the same reagent , no exogenous redox activation is required. To the best of our knowledge, this method for alkyl-CF3 bond formation is perhaps the most operationally simple option currently available. e Crude NMR yield against mesitylene or dibromomethane as internal standard. f dtbbpy was used as ligand instead of dNH2-bpy. g 1.0 equiv. of ArBr was used instead of 1.5 equiv.