For a prove-of concept example showing the flexibility of the approach commented here, the numbers of potentially useful children molecules were downsized to a unique table of 150 candidates, using stringent thresholds maximizing rat wild-type and mutants and minimizing human off-target hits. The method employed here, including the AutoDockVina consensus to confirm low nanomolar affinity predictions, could generated large libraries which could be easily fine tuned to adapt other possible consensus docking data, threshold values and/or starting new evolutionary generations by including any other fitting criteria (i.e, molecular weight, hydrophobicity, number of Nitrogen, Oxygen or rings, etc). Therefore, it should be noted that despite using these powerful approaches, most of the chemical/chemotype space molecular possibilities fitting the rat-VKORC1 cavity still remain to be explored. New algorithms could perhaps be designed to explore further possibilities more exhaustively.