shortcoming was limited. ChemDraw also proposes similar NMR chemical shifts for 3-aminopyridine and 3-fluoropyridine, which is a more serious problem due to the importance of fluorine in medicinal chemistry and due to the fact that organic chemists' good understanding of the EAS chemistry of benzenes does not translate to heteroarenes, let alone to fluorinated heteroaromatics. 1,2,4-Triazoles had to be excluded from the NMR study, and it was speculated if this was due to a different reaction mechanism. RegioSQM considers all aromatic rings and correctly predicts the low reactivity of fluorinated arenes and is also able to account for the high reactivity of 1,2,4-triazoles in most cases. Encouraged by these results RegioSQM was applied to the full dataset.