Recently, Wang et al. reported a 22 % improvement in the ZT due to enhanced band degeneracy upon substituting p-valent Bi in BiCuOSe with d-valent La, predicting a ZT value of 1.46 for n-type LaCuOSe. We posit that a similar band-degeneracy induced enhancement of the thermoelectric performance may be achievable in the A2B2Q6 family by replacing p-valent Sb with a d-valent cation. Several members of the A2B2Q6 family have been experimentally reported thus far, including Sc2Si2Te6 in 2022 however, the thermoelectric properties were not investigated.