The reaction center in Figure is Acyclic, consisting of a single tree, here just a path We conducted an analysis of these descriptors, evaluating them both within the context of the entire database consisting of 34,395 reactions for which we identified the reaction centers (hereafter referred to as the "database"), and our template library, which comprises 311 distinct templates. The overwhelming majority of the database, 87.0%, was categorized as elementary (and thus single-step) reactions, Figure . This percentage decreases to 54.3% of the 311 templates collected in the template library, Figure . More detailed statistics can be found in Supplemental Table . Further analysis of the topological configurations revealed that the Single Cyclic type was by far the most abundant reaction type, comprising 86.6% of the reaction centers across the "database" as depicted in Figure . This dominance persisted in the template library, where Single Cyclic remained the most common configuration, accounting for 48.6%.