The weakening of molecular bonding generally implies a reduction in the activation barriers for subsequent reactions on the surface. Furthermore, considering that these changes correlate with strong adsorption energy, which in turn may impede the desorption and diffu-sion of reagents adsorbed on the doping sites, the results suggest that doping could be a compelling strategy for enhancing surface catalysis on MoTe 2 . This is particularly noteworthy given the large variety in the extent of the effect, allowing for fine-tuning of the sheet's properties. Of course, it should be noted that the extent of the effect of the molecule-sheet interaction will depend on the adsorbate. However, as the mechanism behind the enhanced chemical activity at the doping site remains unchanged, the observed trends between dopants should persist. Thus, the strongest effects should be facilitated by low-atomicnumber elements from groups 13-15, especially B, Si, and P.