Since at present no scoring algorithm has proven yet to be reliable for every chemotype, a consensus between at least two different algorithms seem to be necessary to select the many leads generated by explorations of the vast chemotype space 66, 67 . In this work, a minimal consecutive consensus docking by ranks has been introduced using DW and ADV to theoretically increase prediction accuracies, as suggested in other systems . Therefore, it may be expected that combining low docking-scores, high ligand efficiencies and consensus docking by ranks, helped to improve binding predictions.