Chemical species transport at the tissue and cellular scale within the renal system occurs primarily through diffusion-an essential process for the movement of solutes across cell membranes. Diffusive transport is influenced by several factors, including concentration gradients, temperature, and membrane permeability . The reabsorption of glucose and amino acids in the renal tubules occurs via specialized transport proteins that facilitate their diffusion from the tubular lumen into the bloodstream . Furthermore, enzyme-catalyzed reactions within renal cells contribute to the transformation of these chemical species, affecting their bioavailability and function. Reactions between transported solutes and renal cells can lead to metabolic alterations that exacerbate kidney dysfunction, as seen in conditions such as DN .