Several comments have to do with the location of the herbicide molecule in the x-ray complex of AHAS plus small molecule. Not presented in this work, a computational study was done in docking Chlorsulfuron with a docking radius of 4 and 10 A about the center point of the x-ray coordinates of CS in 1YHZ (with its CS stripped). The docking scores are generally smaller than the P197 region by about 3.5 PLP GOLD score, which is approximately .5 kcal and is a significant difference. (all docking calculations are available in the downloadable supplementary material).