Through the assembly of [cis-(tmeda)Pd(NO3)2] acceptors with 1,4-di(1H-tetrazol-5-yl)benzene and [1,3,5-tri(1Htetrazol-5-yl)benzene], respectively, an interesting case of two aqua-soluble edge-and face-directed tetrahedral cages were generated, followed by a post-metalation process utilizing cisblocked Pd II . Follow-up work in this direction employed changing the central ligand core from benzene to naphthalene and biphenyl, to obtain water-soluble enantiopure assemblies (MOC-4-6) with larger cavities (Figure ). 69 MOC-6 with largest hydrophobic cavity showed a certain selectivity toward 2,2'-diethoxy-1,1'-binapthalene (EtB), where the L4 - MOC-6 showed a preference for R-EtB over S-EtB (75:25), attributed to the superior fit inside the chiral cavity (L/R pair), whereas D4 -MOC-6 preferred S-EtB over R-EtB with similar selectivity (D/S ratio = 73:27). For all these cases, the chiralities were derived from the spatial arrangement of the triazole linkers, which caused the final assemblies to adopt a specific geometry characterized by a loss of symmetry, and to be oriented in the same handedness (DDDD or LLLL) of the vertices, which ultimately conferred chirality. By employing this methodology, a pair of enantiopure Tsymmetric tetrahedral Fe4L6 cages (MOC-7) were synthesized through the utilization of a subcomponent selfassembly technique, as demonstrated by Nitschke et al. The chiral glyceryl group modification defines helical twists of the organic ligands on six edges of the tetrahedron, giving rise to three C2-symmetry axes (Figure ). Additionally, it dictates the stereochemistry of the handedness of the apical Fe II centers, resulting in same handedness for all four vertices. Gu and colleagues extended and modified the chiral auxiliary strategy by using chiral amine-modified organic ligands that were formed in-situ through a diastereoselective subcomponent self-assembly process. This led to the creation of chiral tetrahedral Fe4L6 cages, which demonstrated successful spin-crossover features and exhibited structural interconversion.