Inclusion of long-range van der Waals interactions into C36/LJ-PME model is an important step toward more realistic MD simulations of interfaces, reducing artefacts arising, for example, from acyl chain-vacuum tension. However, C36/LJ-PME together with its standard water model, TIPS3P, fails to reproduce the experimental surface pressure-area isotherms and the expected phase behavior of DPPC and POPC monolayers. These discrepancies result from too low surface tension of the TIPS3P water model. Combining C36/LJ-PME lipid model with OPC4 water model-whose surface tension is closer to experimental one-considerably improves the monolayer phase behavior and agreement with experimental surface pressure-area isotherms. However, the pore forming pressure is underestimated by 10 mN/m when compared to experimental estimates.