We support chemists from discovery all the way to late-stage process development. Our customers reach us by email, chat or stop by. We put this information into our Dotmatics Electronic Lab Notebook (ELN, Version: 6.1-814-s, Figure ). Then we design plates and generate all les needed to run them in the lab in a self-built Google Sheet application. Every plate is sampled at least twice and the analytical data is automatically pushed into Spot re 7 for data analysis. Key results are documented in a Google Slides presentation the scaffold of which is generated automatically. On that basis, our customers decide whether to continue screening or proceed with scale-up. We re ned and built the work ow over the course of more than 1,000 plates and we continue adding new features. Since we didn't know at the outset how the end product should look like, we chose software platforms that allowed us to retain control, build ourselves and iterate quickly. In the following, we will walk you through the work ow and the design rationales behind it. 8 8 The supporting information contains more technical detail as well as the source code and instructions on how to implement everything presented herein. We are aware that our work ow relies on proprietary software such as Google Sheets and Spot re, which might limit exibility and customization. This dependence could pose challenges in terms of data security, software updates, and integration with other platforms.