In this study, we designed and demonstrated computational RNA droplets capable of AND logic operations. Our multi-stranded motif design enabled the programmable phase-state change through target-induced motif restructuring. We also made a comprehensive parametric study using varied materials (DNA and RNA) and interaction mechanisms (SE and KL). The several-base mutations in the palindromic subsequence of the KL region could fine-tune the thermostability of the resulting RNA condensate, in good agreement with the numerical predictions, which allowed us to optimize the sensing motif design. The RNA condensates assembled from the designed sensing motif were studied experimentally for the thermoreversibility and fluidity, showing that the condensates at 30°C were in a liquid state. Our computational enzyme-free RNA droplets based on multi-strand sensing motifs should provide engineers and scientists with significant flexibility and simplicity in programming phase behavior. Our computational RNA droplets, furnished with high flexibility and detectability, will promise their conversion into far-reaching applications ranging from diagnostic devices for detecting various diseases to functional synthetic cells. They would also be applied to molecular computation devices in living cells by coupling with an intracellular transcription system.