Au@Ag nanorods dimers based on Aptamers for ultrasensitive sensing dopamine.So, it notified that the electronic field significantly enhanced by the incorporation of silver shell coating on the surface of Au NR dimer. The surface-enhanced Raman scattering (SERS)-encoded this sensor system, hence exhibiting a LOD of dopamine as low as 0.006 pM and a wide linear range of [0.01 to 10] pM of dopamine detection. According to Sajid's group the electrochemical analysis is the best viable way of dopamine sensing. However, it is very ambitious due to analogous redox potentials of the co-existing and high concentration interfering species in real biological samples. So, the team fully shown the description of different materials, and related characterization by using them in the detection of dopamine. Both novel dimensions, and as well as active challenges are regarded within the study. Moreover, a single layer Nano-MoS2 modified gold electrode (nano-MoS2/GE) has been fabricated by Hun's research group for dopamine sensing. So, under optimal conditions, the developed electrode displayed considerable sensitivity, simplicity and a wide linearity range which staring up a novel promising signal-on the photoelectrochemical (PEC) platform for the determination of small organic molecule in Bioanalysis. Hence, this elaborated sensor holds a detection limit of 2.3*10 -12 M. Recently, Elhag, S.,et al used a hydrothermal chemical deposition (HCD) way to grow an ultra-thin (Co3O4) nanowires over gold coated glass substrates for potentiometric sensing of dopamine. Considerable methods were used in order to characterize the sensor properties, including X-Ray Diffraction, X-Ray Photoelectrons Spectroscopy (XPS), Scanning Electron Microscopy, and as well as Ultraviolet-Visible (UV) absorption technics. So, the sensor shows a linear range with a slope of 52 mV/decade when dopamine concentration is ranging from [10 -9 to 10 -2 ] M. Indeed, the improved electrode features is attributed to the imperfection on the metal oxide (Co3O4) that is settled by the used surfactant along with the full surface area-to-volume ratio. A modification of gold electrode by the use of single-walled carbon nanotubes (SWCNTs) has been adopted by Kurniawan's group as sensor for the detection of dopamine. Indeed, the developed sensor exhibited 0.79 µM, and 3.414 µA.mm-2.µM-1 of detection limit and sensitivity respectively when experienced in dopamine solution at pH 4.0 under the use of cyclic voltammetry technic. Also, the sensor does not exhibits any interference signal for ascorbic acid (AA) under the dopamine detection. Moreover, Kim's team reported a glassy carbon modified graphene electrode through drop-casting way in order to construct high sensitive sensor for the determination of dopamine in the existent of ascorbic acid. So, the performance of this electrode was confirmed in an enough assets of (AA) 1mM. The linear range was between 4 µM to 100 µM of dopamine concentration. The developed electrode revealed a detection limit of 2.64 µM. In particular, Wu's group reported a special type of porphyrin-functionalized graphene for high selective and sensitive sensing of dopamine (DA). Indeed, the limit of detection of this electrode was as low as 0.01 µM. And specially, a possible peak potential separation was observed at 188 mV, 144 mV and 332 mV for AA-DA, DA-UA and UA-AA respectively, which allows selectively sensing DA. Therefore, with respect to the good sensitivity and selectivity of this new-kinds of electrode, this sensor was applied to determine (DA) in real hydrochloride injection sample, human urine and as well as serum samples with a satisfactory outcome.