Recently, the design of bioactive microdroplets enabling the adhesion and culture of adherent cells has been proposed . Indeed, it was discovered that the self-assembly of proteins at liquidliquid interfaces could enable the formation of protein nanosheets displaying strong mechanical properties, able to resist cell-mediated contractile forces . In these systems, the protein nanosheets formed play a triple role, stabilising corresponding interfaces and associated emulsions (tensioactive), forming a percolated network with strong interfacial viscoelastic properties (scaffolding) and presenting ligands able to engage with cell membrane receptors (bioactivity). In turn, the resulting bioactive liquid-liquid interfaces and bioactive emulsions (or bioemulsions), enable the regulation of cell adhesion and maintenance of stem cell phenotype . The role of interfacial shear mechanics, to enable the mechanical engagement of integrin receptors and downstream mechanosensing cascades was found to be essential to allow the maintenance of stem cell phenotype upon culture at liquid-liquid interfaces or on bioemulsions.