Average bond lengths, angles, and ring dihedrals (Supporting Information) agree with experimental data for all twelve anomers. Comparing these geometric variables with and without mutual polarization, we see that polarization does not change the structure of the monosaccharides, nor does it yield enhanced flexibility. This suggests that force field accuracy is mainly revealed in the solution properties of the modeled carbohydrates (i.e., the structure and density of the hydration layer, diffusivity, etc.), which will be the focus of this paper. Nevertheless, we note two observations about the conformation of these monosaccharides, as predicted with AMOEBA.