Of all the compounds evaluated on HepG2 cells, compound 8 exhibited the highest cytotoxic activity and was chosen for the further evaluation on a variety of hepatocyte cancer cell lines: Hep3B, Huh7, and Huh7R, with the results compared with those of madecassic acid (2), using the MTT assay (Table ). The antiproliferative activity of compound 8 was much greater than that of madecassic acid, with the GI50 decreased by multiples of 15.1 to 18.5 respectively for Hep3B, Huh7, and Huh7R