As a second example of identification of materials with specific topology, we focus here on the intriguing behavior of zirconium tungstate, ZrW 2 O 8 , which exhibits a number of counterintuitive mechanical responses to external stimuli: it has negative thermal expansion, very easy amorphization under hydrostatic pressure, and features negative hydration expansion, i.e., it contracts upon chemisorption of water molecules. These unusual characteristics have been recently linked to its microscopic structure, and in particular, the topology of this remarkable material (see Figure ). Further investigations would require in-depth screening of the properties of these materials, e.g., by DFT calculations and geometric determination of their void spaces, in order to identify the best candidates for thermal and mechanical properties similar to parent compound ZrW 2 O 8 . We showed here how the availability of a materials database annotated with topological information can prove valuable in the exploration of chemical space of materials.