To address these problems, in Section 2.2, we proposed the flat-bottom elastic network model (FB-ENM), which constrains interatomic distances using piecewise quadratic functions with flat bottoms. FB-ENM resolves Factor i by imposing substantial constraints only on the minimum number of atom pairs necessary to preserve the significant structural elements and weak constraints on other pairs to prevent excessive shortening/lengthening of interatomic distances. It also resolves Factor ii by allowing the path to move freely within the flat bottom of the total energy, i.e., the set of collision-free structures preserving the structural elements. Furthermore, the piecewise quadratic pair potentials of FB-ENM resolve Factors iii and iv.