Studies of vanillin hydrogenation in the mobile phase are even less common, as this requires a catalyst with excellent stability and long-lasting activity under tolerant environmental conditions. Based on our previous studies of similar carriers in continuous flow ,we decided to carry out a vanillin hydrogenation study in a continuous flow system. The development of non-homogeneous catalysts for continuous flow systems facilitates industrial-scale applications as the process of utilising biomass platform compounds requires that they can be operated at long cycle times and on a large scale. In addition, the control of material and temperature, etc., guaranteed by the flow process allows for tunability of the reaction products 33, 34 .The flow system can monitor and control the reaction process in real time, start or stop the reaction at any time, and can add raw materials during the reaction process and adjust the flow rate to control the reaction time, which is a flexible, controllable, convenient and efficient reaction system . The flow reactor can react the liquid material after gasification in contact with the loaded catalyst, and the reaction efficiency can be significantly improved. Moreover, because the system is fully mixed in multiple phases, local under-hydrogenation is avoided and by-product generation is reduced while improving efficiency. However, this flow system is not without challenges; solid blockages in small size channels and multiphase mixing may affect or even stop the desired reaction altogether. Therefore, the catalyst in this flow system must be as low as possible in terms of metal loss and ensure high recovery. Therefore, the preparation of new catalysts and the optimization of flow conditions have become indispensable challenges in the development of flow reactor hydrogenation. This work describes a simple and environmentally friendly method to prepare transition bimetallic catalysts Ni/Co@NDC for the selective conversion of vanillin. The catalyst uses transition metals as the active catalytic center, which greatly reduces the preparation cost, and the resulting catalyst is stable and reusable. The reaction was carried out under very mild conditions requiring only 3 bar hydrogen pressure and only a change in reaction temperature to selectively convert readily available lignin platform compounds to VA or MMP at a flow rate of 0.2 mL/min in a highly efficient flow reactor system, thus providing a viable pathway for the low-cost utilization of lignin platform compounds.