The sequence of the protease domain of TMPRSS2 was analyzed with BLASTp to identify the best available structural templates. The top five templates by sequence identity were selected including kallikrein (PDB ID 6O1G), matriptase (PDB ID 1EAX), coagulation factor XI (PDB ID 4TY6), coagulation factor VII (PDB ID 5PAB), and TMPRSS11E (PDB ID 2OQ5). Template identities ranged from 38-44%.