Concerning Zika virus (ZIKV), is a human pathogen responsible for a devastating epidemic in the Americas and still jeopardizes public health. ZIKV is a mosquito-borne virus belongs to the family Flaviviridae that contains several viruses of clinical importance such as dengue virus (DENV) and West Nile virus (WNV) . ZIKV was first isolated in 1947 from a macaque monkey in the Zika Forest in Uganda .