A structural complication encountered for rROP-made (bio)degradable copolymers is that the comonomer needs to be homogenously incorporated within the polymer backbones to confer substantial hydrolytic degradability into the parent (vinyl) polymer. The degree of homogeneity of comonomer incorporation depends on the monomer reactivity ratios, being the ratios of homo-to cross propagation rate coefficients, as well as on the polymerization time, temperature, initial monomer concentration, and monomer addition profile(s), the latter supported by more recent modeling studies with less conventional monomer reactivity ratios.