This advance allowed the initial substrate scope summarized in Figure to be significantly expanded. As shown in Figure , a diverse range of functionalized electron-rich Weinreb amides were compatible with the modified procedure (up to 95% yield). Gratifyingly, these conditions also allowed the parent Weinreb amide (Ar = Ph) to be processed efficiently and smoothly to 2aa (89%). Methylation and halogenation of the aryl group was generally well-tolerated (2ab-2ai, up to 89%), and the introduction of a proximal phenyl group to the N-center did not induce cyclization, enabling the biphenyl product 2aj to be accessed (73%). Highly electron-rich substrates were compatible with the photocleavage conditions, enabling facile access to amides 2ak, 2al, and 2am (86%, 84%, 36% respectively). More challenging examples include the diphenyl acetylene derivative 2an, the furan 2ao and the indole 2ap. Gratifyingly, it was possible to induce direct N-O bond cleavage of the N-OH derivative (2aa, 35%) and to access the primary amide directly (2aq, 95%). To exploit the redox-neutral nature of the process, a series of cyclic substrates were exposed to the standard reaction conditions using anthracene. Successful cleavage to the protected aminoaldehyde not only supports the working hypothesis, but also provides a convenient platform to generate ambiphilic building blocks of varying chain length. This would complement Fischer´s remarkable 1 synthesis of aminoacetaldehye, a reaction lauded by Prof. Sir John Cornforth, and enable access to the protected C3 and C4 congeners (Figure ).