The undeniable value of this transformation can be contextualized in the case studies outlined in Figure . These examples are organized by contrasting well-trodden multi-step polar-bond approaches to the simplified routes enabled by radical retrosynthesis (DCC). For example, a popular synthesis of unnatural amino acids originates from glutamic acid via Negishi coupling. This polar tactic for the construction of these molecules relies on the synthesis of the C(sp 3 ) organometallic reagents via multiple FG manipulations. In contrast, the same product can be obtained with a reductive decarboxylative cross-coupling starting from the RAE of the native amino acid and the desired aryl halide partner. In this case, the use of Ag-Ni electrocatalysis is singularly successful amongst all methods evaluated (when free phenols and heterocycles are employed). Thus, the DCC approach is attractive in terms of ideality, scalability, and rapid access to diversity.