We apply the proposed method to design solvents for two different applications, namely the purification of γ-valerolactone and the extraction of phenol from water. The results are compared with benchmarks from the literature, where initialization is based on intuition, which we refer to as the cold start. Both case studies demonstrate that the screening-guided warm start significantly accelerates convergence of the genetic algorithm in the COSMO-580 CAMD framework. With a warm start, the identical optimal solvent can be found within a maximum of 10 generations across all cases analyzed in this work. In contrast, a cold start requires much more generations to achieve the same optimal molecule candidate and can yield a sub-optimal solution even after 50 generations.