The MAP (MinHashed Atom-Pair) fingerprint of a molecule consists in a series of MinHashes computed from the list of its molecular shingles. A molecular shingle is written for each possible pair of circular substructures of a given diameter (2 bonds for MAP2, 4 bonds for MAP4, 6 bonds for MAP6), written as canonicalized SMILES, separated by the shortest topological distance separating the central atoms, counted in bonds. We preserve the Z/E double bond information in all shingles whenever the entire double bond is included in a shingle. To encode stereocenter information into our fingerprints, we label chiral atoms with their Cahn-Ingold-Prelog (CIP) descriptor (R, S, r or s), as computed by RDKit, whenever stereochemistry is defined, or label them with a question mark ("?") if stereochemistry is not specified. Importantly, we only apply the chiral label when a chiral atom is the central atom of a circular substructure and only for shingles with the largest diameter considered. The concept is illustrated for one of the possible pairs involving the stereocenter in polymyxin B2 (1, Figure ).