Applications can target (i) highthroughput mining of novel enzymes in genomic and metagenomic databases, and (ii) in silico computational enzyme evolution. Rational protein design can focus on (iii) the reconstruction of robust ancestral enzymes, (iv) the engineering of highly enantioselective enzymes, and (v) the engineering of highly active enzymes. The enzymes before optimization are shown in brown, while the enzymes mined or engineered using quantum computing are shown in blue. The demonstration of quantum speedup is achievable in each of these domains of biocatalysis and will depend on available computing power.