Herein, we report constructing and curating the Epi Food Chemical Database, which contains 187 chemical compounds from dietary and natural products. The database includes structural information and the epigenetic activity profile obtained from the literature vs. 46 epigenetic targets. Breast cancer is by far the disease discussed in the literature with the largest number of epigenetic targets that are dysregulated. We used chemoinformatic tools to compare and analyze the structural content, diversity, and chemical space.