Since previous studies have concluded that isocyanate reactions can be accelerated by basic catalysis and that treating them with base can greatly increase its rate of nucleophilic addition, we added common organic bases such as 1,8-Diazabicyclo[5.4.0]undec-7-ene (DBU), 1,4diazabicyclo[2.2.2]octane (DABCO), 4-Dimethylaminopyridine (DMAP), N,N-Diisopropylethylamine (DIPEA), and triethylamine (TEA), which resulted in either no reactivity, or rapid decomposition and regression of conversion in pyridine as shown in Table , Entries 1-17. Isocyanates are subject to hydrolysis upon exposure to moisture, and this correlates with our findings that increased moisture resulted in lower yields (Fig. ). Liquid chromatographymass spectrometry (LC-MS) analysis of the crude reaction mixture showed dihexyl urea as a major byproduct of this reaction when performed in wet solvent.