The efficacy of in situ OAC generation from palladate 2 was next examined in a catalytic context using a Suzuki-Miyaura coupling method tailored for base-sensitive boron reactions (Table ). These conditions present a challenging test case for activation of other Pd precatalysts. The absence of a strong base or nucleophile mitigates fast protodeboronation (PDB) of the unstable boronic ester, yet many precatalyst activation mechanisms proceed by the action of a strong base or nucleophile. Biaryl 4 was formed in 76% yield along with 35% PDB side product (averages of two reactions) within 2 h at RT using the reported OAC 1 as catalyst. Substituting PAd3 and 2 for isolated 1 in this reaction formed biaryl 4 in comparable yield (71%) under otherwise identical conditions. On the other hand, the use of other contemporary precatalysts, such as (PAd3)Pd-G3, (PAd3)Pd(t-Bu-indenyl)Cl, and (PAd3)Pd(α-Menaphthyl)Br (Table , entries 3-6) generated only 4-24% biaryl along with substantial amounts of PDB side product. These results highlight both the premier activity of Pd OACs in demanding catalytic applications as well as the capacity of 2 to act as a surrogate for isolated OACs.