CACHE plans to launch challenges for each of the five hit-finding scenarios shown in figure , each challenge comprising 3 different protein targets, and occurring over 2 years. There will be periodic public open calls for participation. For the first rounds, letters of intent will be solicited to better understand the needs and goals of potential participants. All potential participants would be asked to submit brief applications detailing their qualifications to participate and general intended approach. For inclusivity, the initiative should strive to accept every reasonable application, with due attention being paid to use resources efficiently.