Another previous study showed that nidurufin (37) had exhibited strong anticancer activity against the A-549 cells, the human ovarian cancer cells SK-OV-3, the human skin cancer cells Compound 38, showed weak antibacterial activity against the Gram-positive S. aureus as well as Gram-negative E. coli with inhibition zones of 7 and 6.5 mm, respectively using disk diffusion method at a concentration of 20 μg/disk , suggesting that the new derivatization in this compound affected the antibacterial activity of the parent metabolite, nidurufin which showed better antibacterial activity when tested against the Gram-positive bacteria as discussed above.