In our development of new or improved molecular discovery technologies we aim to achieve two goals: Make the technology available to the widest array of practitioners and access the most diverse chemical space. Our manuscript shows that chemical modification of 10 5 preselected phage displayed peptides makes it possible to discover chemically upgraded macro-bicyclic peptides using a simple pulldown and NGS (2 days of hands-on work). High throughput screening (HTS) is a commonly utilized approach for molecular discovery, but wide utility of HTS is limited by cost of liquid-handling robotics that can handle >10 5 molecules, and the requirement for the state-of-the-art expertise in building the chemical libraries. Libraries of >10 compounds deconvoluted by mass-spectrometry (MS) are attractive alternatives to microwell-HTS, but their widespread adoption is hampered by the staggering cost of MS equipment.