ORF8 shows a high number of variations and its largest interactome suggested it is implicated in many different functions . For instance, some of the effects known to be modulated by ORF8 include host endoplasmic stress , histone modification , SARS-CoV-2 spike S expression , inhibition of complement , inhibition of human interferon responses , binding to dendritic cells producer of inflammatory cytokines , activation of the IL17 pathway , inhibition of antibody-dependent cellular cytotoxicity , activation of pro-inflammatory storm-causing cytokines trough NLPR3 and dimer-dependent downregulation of MHC1 in human cytotoxic lymphocytes to favour viral immune evasion .