Hence, 21,882 molecules in COCONUT do not possess any circular structures. Of 406,747, the share of linear molecules is low (5 %), but one should keep in mind that these structures are usually completely neglected in ring-based analyses like most scaffold methods. The first observation here is that the share of nitrogen hetero cycles is higher in these drug molecules than in NP structures. This has been reported before . Also, the share of linear molecules (1,467 of 11,172, 13 %) is much higher than in NP. Benzene is again the most frequent scaffold in both analyses. But while it is by far the most frequent scaffold in the DrugBank network (6,578 origin molecules compared to 972 for the second most frequent scaffold, pyridine), its prominence is way lower in the forest (1,819 origin molecules compared to 611 for pyrimidine in second place).