In addition to the slightly faster lipid flip-flop rates on average, the equilibrated fractions of cholesterol are also slightly higher (0.59 vs 0.55) in the extracellular leaflet. The phospholipids in the Martini 3 model also diffuse slightly faster in both leaflets and as observed previously with the Martini 2 model, the phospholipids of the extracellular leaflet have slower lateral diffusion rates than those in the PUFA-rich cytoplasmic leaflet (see Table ). Both leaflets of the Martini 3 model are found to be slightly more ordered than those of the Martini 2 model. The extracellular leaflet is more ordered than the cytoplasmic leaflet, as expected due to the asymmetric distribution of lipids with saturated and unsaturated tails.