Aside from parameter changes, another notable trend from the training targets is the systematic overprediction of enthalpies of mixing for aqueous mixtures, as shown in Figure , Panel C. That this systematic overprediction was slightly reduced, but not corrected, points to a larger issue with the aqueous mixtures. Since the water model used in refitting (TIP3P) was not refit, the optimization algorithm was likely unable to eliminate this error by adjusting the non-aqueous components alone. This indicates in order to significantly improve aqueous mixtures, we would likely need to retrain a water model in a future version of the force field or pursue a more aggressive optimization of these aqueous physical properties.