For project 1, a group of 7 students selected this PBL project. In inquiring why they selected this project, they explained that this project could allow them to use what they have learned from lectures of physical chemistry and organic chemistry. This has partly proven that the project design is appropriate to practice first principles thinking. To strengthen the usage of first principles thinking, cascades of coupled inquiries (inquiry-based technique) were designed to drive the students to reversely breakdown the complex problems to the fundamental principles in the supervision meetings. The cascade of main questions is shown as follows.