Finally, we challenged Swarm-CG for the optimization of CG models of complex macromolecules, for which we use as case study a spermine-based dendron (flexible, small and directional branched macromolecule), and PAMAM dendrimers generations 1 (G1, symmetric/non-directional, small and flexible branched macromolecule) and 2 (G2, large, symmetric/non-directional and complex branched macromolecule). For these cases, only the results of execution mode 1 are reported, as execution mode 2 provided an analogous picture. In fact, while these complex architectures could suffer of reduced sampling at AA-MD level, their highly symmetric hyperbranched structure allows for a good analysis of the geoms, as Swarm-CG averages the behavior the identical/symmetric side branches.