Following a rule of three (RO3) evaluation, the fragments were hybridized . Selected compounds with best affinity were further examined using drug-likeness characteristics, and in silico pharmacokinetics and toxicity studies were conducted using the ADMETlab 2.0 and Protox-II web servers () and tox-new.charite.de, respectively. The pharmacokinetic features of absorption, distribution, metabolism, and excretion (ADME) as well as specific drug-likeness factors were assessed using the ADMETlab 2.0. On web servers for Protox-II and ADMETlab 2.0, the toxicity investigations were carried out. A two-way analysis of variance (ANOVA) with replication, a residual error test, and Tukey's multiple comparison test were used to statistically examine the data .