Historically, natural products (NPs) have been the biggest source of bioactive compounds for medicinal chemistry. For instance, in cancer research, in the lapse of time 1946 to 1980, seventy-five small molecules were approved worldwide, of which 53% were unaltered NPs or natural product (NP) derivatives. Moreover, from 1981 to 2019, of the 185 small molecules approved to treat cancer, 64.9% were unaltered NPs and synthetic drugs with a NP pharmacophore . Another example is the actual development of new promising antibiotics against drug-resistant bacteria from NPs . Furthermore, in a recent review it was shown that 697 natural steroidal alkaloids were isolated and characterized with various biological activities, from 1926 to 2021 . The bioactive compounds encompass marine , fungal , bacteria , plants and endogenous substances produced by humans and animals, sources , including venoms and poisons produced by different animals . Even, as recently reviewed, the fruit peels are a source of bioactive compounds that in many instances display better biological and pharmacological applications than the compounds of other sections of the fruit .