The AdSoS setup is designed to keep the thermodynamic mismatches in the system to a minimum by imposing near-ideal mixing properties for molecules at comparable s-values, a smooth continuous change of the s-value with position and an appropriate pressure heterogeneity enabled by the drift force. However, variations of s may still cause artifacts, which are expected to become increasingly pronounced for high s-gradients. Additional causes may include: (i) the implicit use of an ad hoc geometric-mean rule to combine the s i and s j factors within the pairwise interactions (Eq. ( ) and ( )); (ii) specific close-range packing and orientation alterations between the solvent molecules in (or close to) regions presenting s-variations; and (iii) the use of cutoff truncation in the calculation of the non-bonded interactions. In the context of an atomic solvent , possible artifacts only concern the density, and affect nearly exclusively the SG region as well as the FG-SG and SG-CG interfaces. In the context of a molecular solvent, one also has to consider the possibility of artifacts in the orientation of the solvent molecules. If the solvent is polar (e.g. water), this may result in an erroneous solvent polarization around the solute. In practice, both types of artifacts are expected to remain limited in the case of sufficiently low s-gradients, and residual effects can be corrected by application of positional (for the density) and orientational (for the polarization) grid-based correction potentials. These potentials should be calibrated in the absence of a solute, i.e. in the situation where solvent homogeneity and isotropy are expected, and then assumed to be portable from system to system, i.e. applicable irrespective of the solute.