Let x α and v α be the position and velocity of an MMVT trajectory, at any time, t, in the Voronoi cell, V α . The variables x α * and v α * are the position and velocity of the trajectory at time, t + ∆t, as predicted by the simulation time integrator algorithm (typically, the Langevin integrator). Reflective boundary conditions are employed to keep the trajectories within each Voronoi cell, as represented by equations 8 and 9, respectively. Let π α be the probability of an ensemble of unconstrained longtimescale trajectories being in a particular Voronoi cell when the system has reached equilibrium. For Voronoi cell V α , let T α be the total simulation time in that cell. A normalizing factor, T, is given by equation 10.