To investigate tau protein, we implemented bioinformatics methodologies, including protein structure domain search tools. The results indicated that tau protein contains domains such as pyruvate kinase, phosphatase, telomere binding and transposition, HNH cas9, replicators binding, helicase, DNA polymerase and nuclease, similar transcription factors, promoter binding (TATA-box), enhancer binding (Homeobox, MADS-box, HMG box), and mitochondrial localization. It means that tau protein could transpose telomere fragments to promoter/enhancer regions, which then mess up RNA polymerase II and lower the number of copies of DNA genes (in the nucleus or mitochondrial) .