This approach is complementary to the comparisons of partition coefficients as it gives information also on the detailed interactions between lipids and small molecules in addition to the binding affinity. While straightforward application of ECC to standard force fields has substantially improved the ion binding behaviour, the small molecules seem to require further optimization. Nevertheless, we believe that our results pave the way toward force fields that would correctly capture lipid membrane interactions with charged biomolecules and amino acids. Such force fields have potential applications in a wide range of fields, from drug design to molecular biology and toxicology.