Subsequently, we extended the application of our method to the more complex chemical case of the Diels-Alder reaction between 1,3-butadiene and ethylene. For this system, we deliberately chose to include all 15 possible interatomic distances among the heavy (carbon) atoms in the molecule as descriptors (see SI), rather than preselecting only the two most relevant C -C distances involved in the reactive process. This decision, made regardless of whether these distances directly describe relevant bonds in either metastable state, was aimed at testing the robustness and general applicability of the method. Figure .2 illustrates the progression of Loxodynamics for the Diels-Alder reaction. The method successfully identifies key reaction pathways in both forward and reverse directions without relying on predefined mechanistic knowledge.