Because of previous work, the viral hemorrhagic septicemia virus (VHSV) has been chosen here as one of the fish rhabdoviruses example to computationally explore for possible drug-like alternatives. Isolated from > 65 fish species (~ 20 farmed) , and increasingly found in free-living marine fish species , VHSV causes one of the highest economic impacts in fish farming. Many VHSV isolated world-wide have been grouped into 4 nucleoprotein genotypes with 9 subtypes ().