A key innovation of this work lies in the functionalization of sperm-based microcarriers with an outer TiFe/Au coating decorated with multiple nanoreservoirs. The integration of polymeric vesicles onto the microcarrier surface enhances drug and enzyme loading versatility and stability, broadening the range of therapeutic agents that can be administered. Notably, our approach employs two distinct polymeric nanocompartments, each tailored for specific therapeutic functions by modifying their block copolymer composition. Optimizing the surface with these nanoreservoirs opens new possibilities for cascade reactions, including pro-drug activation and integrated sensing capabilities. Comprehensive characterization confirms the successful immobilization of HYAL-and MMP-1-loaded Psomes, as well as curcumin-loaded Psomes, onto the microcarrier surface. Additionally, we propose two strategies for targeted transport of microcarriers to cancerous sites: (1) propulsion via motile sperm and (2) guidance using an externally rotating magnetic field with feedback control. Biocompatibility tests demonstrate that the microcarriers and their immobilized payloads do not impair sperm motility.