In order to demonstrate the practical utility of Netsci on a real system of biomedical interest, we perform a number of analyses using GC on the SERCA pump. As mentioned previously, the SERCA pump binds ATP (or dATP), which induces an allosteric mechanism that binds and pumps calcium ions across a lipid bilayer. We first examine the correlated motions between the nucleotide (ATP or dATP) bound in the active site and the alpha carbons within the entire protein (Fig. ).