The transient C-H functionalisation strategy provides a reactive handle that is immediately available for further diversification reactions without requiring unmasking of an amide directing group. This was demonstrated by reaction of these sulfonyl aldehydes to provide broader sulfone containing derivatives with motifs of value in medicinal chemistry. Reduction of the aldehyde with LiBH4, gave alcohol 33 and morpholine containing 34 was prepared by reductive amination. The addition of a Grignard reagent furnished secondary alcohol 35 in 91% yield. Piperidine 36 was synthesised by a Pictet Spengler reaction with tryptamine. Oxidative methods were also suitable to access sulfonyl acid 37 and benzimidazole 38 in excellent yield. CuF 2 (2.0 equiv) Cu(OAc) 2 (50 mol%) K 2 CO 3 (2.0 equiv)