[119] The fragmenting procedure identified 261 cores, which were then used for the text search in the preprocessed ZINC database. 3091 computational hits were identified. 67 cores matched at least one molecule in ZINC, however, only seven minimally-overlapping cores resulted in more than two hits (Figure ). Note that this method only finds analogs by matching cores; it is not designed to directly add more cores to the chemical space, but only to enrich those that are already represented in the queries. Nonetheless, the results might be fragmented again and used for another round of virtual screening: this would increase the coverage of the chemical space at the cost of adding more diverse analogs. In this example, the total size of the database increased ~26-fold. However, a significant number of hits could be found only for a few cores, whose SAR could be characterized. For instance, the most represented core had over a thousand hits and two substitution sites. A selection of these hits might be readily acquired and tested experimentally (Figure ).