The last class of compounds in this study are non-covalent interaction complexes. We chose two very prominent examples, namely the hydrogen bonding complexes between the DNA base-pairs adenine and thymine 10, and guanine and cytosine 11. Applying the CoGEF procedure on those complexes leads to the observed MPES shown in Figure . In those MPESs, no discontinuity is observed and the overall behavior resembles more that of a classical BPES. Looking at the Force over strain plots in the lower part of Figure , one can easily deduce two maxima associated with two consecutive rupture events in those complexes. Indeed, in case of 11 two hydrogen bonds are lost after 9.5% strain and the last one persists up to 38 % strain. The maximum Force observed for those hydrogen bonds is 1 order of magnitude smaller then for covalent bonds, as expected. While the absolute values of the SDs of the descriptors shown in Table are therefore also significantly smaller than those observed for the covalently bonded compounds, the RSDs are the highest among the investigated systems. All F max values have RSDs close to or exceeding the 10 % mark and the overall RSD for all systems is the largest (above 12 %). It was repeatedly reported that the maximum Force predicted by CoGEF calculations is far from the values observed experimentally.