With the integration of EnzymeML the interoperability and compatibility of the tools and databases will be improved, and possible current limitations and inconsistencies in the data models of the repositories will be resolved. In the future, EnzymeML will be combined with other standards to enrich the data model and to connect disciplines that are relevant to enzymology. Incorporating AniML or SiLA enables access to laboratory devices, and ThermoML 42 offers a comprehensive description of the reaction medium.