In particular the second subset of trajectories reveals a process for which a single molecule detaches via a flipped configuration as illustrated in Fig. in blue. Trajectory analysis reveals that a flipped intermediate configuration is observed on average in 10% of the detachment events, however the observation of this mechanism is markedly surface and solvent dependent. The highest occurrence of detachment events following this mechanism is observed in water, where more than 80% of the trajectories follow this pathway. For some surface/solvent combinations, for example {100} apolar in ethanol or {002} in toluene, this mechanism is never observed. This observation shows how the solvent affects the behaviour of a growth unit upon removal from the surface, practically altering the defect formation mechanism.