Polyepoxides are increasingly used to replace heavier materials in structural roles, bonding agents between dissimilar substrates, and matrices for high-performance composite materials, relevant for military and commercial applications. Physical (e.g., roughening) and chemical (e.g., coupling agents) surface treatments dictate, to a great extent, the durability and effectiveness of these interfaces, together with environmental curing conditions, such as temperature, atmospheric composition, mechanical stress, and relative humidity. Therefore, it is crucial to identify any changes at the poly epoxy-inorganic substrate interfaces that can become the source of failure, ideally in real-time. This study aimed to investigate how the quality of a polyepoxy/inorganic substrate interface changes (degrades) during cure and aging under confinement using the unique in situ interface imaging and force measuring capabilities of the Surface Forces Apparatus (SFA) via multiple beam interferometry.