As described in the Methods section, the database of metal-based approved drugs (MetAP DB) was assembled from a literature search, plus searching the DrugBank portal, V. 2024. Each approved drug was ordered into five categories according to their clinical use: metallodrug, imagenology metallodrug, photodynamic therapy metallodrug, radioimagenology metallodrug, and radiotherapy metallodrug. The current version of MetAP DB has 61 compounds, of which 56% are used in different therapeutic applications (38% for conventional drug therapies, 10% in radiotherapies, and 8% in photodynamic therapies), and 44% are used in different types of clinical diagnosis (23% is used in imagenology diagnosis and 21% in radioimagenology diagnosis). The number of each drug by category is illustrated in Figure . Figure describes the frequency of compounds that contain specific metals in their structures, where metals like Gd, Pt, Tc, Au, Fe, and Lu are the most frequent.