The scaffold diversity was also quantified based on the number of cores and analog series, and their ratio compared with the total number of molecules in the dataset. We have previously used the number of identifiable cores and analog series as a measure of chemical diversity in a dataset. However, the 11 data sets presented here are too variable in their size. Therefore, we propose two new indicators: the fraction of molecules in the constellation plot (only analog series with at least three compounds are included there) and the average size of the analog series, measured as the number of unique compounds in the dataset divided by the number of analog series represented in it.