We also found differences between calculated scores for the 265 compounds-in-common between the 1,109 (P&D) and 1,282 (Probe Miner) sets. This could be attributed to the differences in the scoring methodology but also the associated data (i.e. not all experimental probes have PMIS). While Probe Miner currently employs bioactivity data from ChEMBL and BindingDB, P&D uses more recent versions and complements these with smaller data sources such GtoPdb. This is reflected in a high P&D score for 150 experimental probes (with 55 highlyrated by CPOC) while Probe Miner detects 20 (including 10 based on the CPOC).