Another promising simulation strategy to avoid solute depletion is the adaptive resolution scheme. Here, a closed system contains a high-resolution region of interest coupled to a low-resolution, coarse-grained representation of solute/solvent. In the case of nucleation, for example, the crystal nucleus and its immediate environment can be modelled with atomic detail. As the nucleus grows, a smooth transformation of the model for solute and solvent molecules occurs by extending the region of the system modelled with high resolution. There are no known examples of applying such approaches to study crystallisation. Both the coarse-grained model and the method by which the molecule representations are transformed must be performed carefully to ensure the properties of the system are maintained.