Therefore, every reaction entry in MITE should come with one or more associated "validated" reaction pairs, where substrate(s) and product(s) are represented as full chemical structures in SMILES format. Besides exemplifying the reaction, these authentic "validated" reaction pairs allow testing the reaction SMARTS in the form of a "validation check": if applied to the authentic substrate SMILES, does the reaction SMARTS lead to the intended product SMILES? Ideally, these validated reaction pairs would be experimentally verified and stoichiometrically balanced, ensuring a high level of confidence.