Because of those limitations, CG models must be developed of the RNTs in order to explore longer time and larger length scales. A versatile coarse-graining scheme, such as the MARTINI FF, can provide the foundation to explore the interactions of RNTs and RNT porins with other molecules, such as lipids, proteins, DNA, RNA, or other small molecules like α-cyclodextrin. An accurate CG model of the RNT and subsequent RNT porin systems could help with understanding the mechanisms to improve the systems. Simulations can provide details that are difficult, expensive, or impossible to obtain from experiments. They can complement experimental analyses, and predict the effects of different variables.