Despite finding possible ligand candidates, the consensus top-children predictions mentioned above are limited in their possible applications. For instance: a) the engineered and simplified Vif blue Vif red sA3G±RNA models may not yet accurately reflect all their possible interfaces, b) the accuracy of the searches limited to high affinity candidates, will require experimental confirmation, c) docking have been performed with fixed rather than side-chain dynamic docking-cavities, in the absence of water interactions, and any of both properties may interfere and/or d) there were a limited number of docking cavities explored on the Vif complexes compared to many other protein interfaces and to their vast numbers of their chemical-space alternatives. Despite these limitations, some of the newly identified top-children targeting the Vif blue Vif red sA3G±RNA models could be experimentally tested or provide some examples of similar strategies to apply to further antiVif explorations.