Irrespective of the complexities associated with EAB respiration, certain bottlenecks (rate-limiting steps) in the overall mechanism will invariably exert disproportionate control over the kinetics of the entire process. This means that in measuring the effective activation energy of a complex reaction (EA eff ), one is approximately measuring the EA of the bottleneck reaction(s) (EA bot ). In the present case, contributions to EA eff can include the Krebs enzymatic cycle responsible for EAB acetate oxidation via Michaelis-Menten kinetics (and the mass transport that supports it), subsequent EET through a cytochrome c enzyme network to an anode, and final chemical reduction at a cathode.