In both TMAO force fields, the water density in the 1 st solvation shell of neopentane is quite similar for pure water and water-TMAO solutions. A significantly high population of water molecules around hydrophobe is always found in water-urea solution compare to that in pure water or water-TMAO. In this context, it is important to mention that a strong force field dependency is identified for water-urea-TMAO mixture. In the case of Garcia's TMAO force field, the peak height is highest and for Netz's TMAO force field, the peak height is lowest in comparison to that in pure water, water-TMAO and water-urea mixtures.