Data related to NPs, and specifically to NP dereplication, are stored in databases. Existent NP databases in the public domain have been reviewed recently by Sorokina and Steinbeck, until 2020. Previously, in 2015, Johnson and Lange reviewed open-access metabolomics databases for NP research. Databases focused on NP dereplication relate structural information to spectral and/or chromatographic information of compounds and taxonomic knowledge on NP sources. Those types of databases can be classified according to the spectrometric or spectroscopic information they support, i.e. MS or NMR data. NAPROC-13 is a freely web-based accessible and searchable database at , that collects structural and C NMR spectral information on NPs, of which a considerable number of their structures have been reviewed. NAPROC-13 contains information regarding 24,722 compounds (21,250 after applying a chemoinformatics-based curation protocol), mostly from plant sources, and in less amount from marine and microbiological organisms. By geographical distribution, systematic introductions of NPs are limited to those from Panama and El Salvador. Most of the entries in NAPROC-13 come from various unespecified countries worldwide. Information on chemical structures is not freely downloadable. NAPROC-13 has captured more relevance each year as evidenced by the 106 citations, 619 downloads, and 2,916 views of the original publication (updated to May 1 st , 2024) , and has more than 800 registered users from many countries around the world. In addition, a recent publication reporting on the usefulness of NAPROC-13 as a new strategy for finding erroneously established NPs contains, reports of over 3200 views. The main goal of this study is to analyze quantitatively the chemical content, diversity, and coverage in the chemical space of NPs in the latest release of NAPROC-13. Chemoinformatic and statistical tools were applied for this purpose. The database was compared to the Food and Drug Administration of the United States (FDA)-approved drugs and a diverse subset of NPs (known as UNPD-A) regarding physicochemical and constitutional descriptors. To this end, we computed molecular descriptors of pharmaceutical interest, among others, and discussed the structural complexity as quantified by standard metrics. Also, we contrasted the structural diversity of compounds in NAPROC-13 according to different types of representations: 1) molecular fingerprints of different designs, 2) scaffold content according to Bemis and