Recent studies have shown that alterations in the glyoxylate and dicarboxylate metabolism pathway may contribute to cancer development and progression by influencing key cellular processes. For example, dysregulation of enzymes involved in this pathway, such as isocitrate lyase (ICL) and malate synthase (MS), has been shown to promote tumor growth and metastasis in certain types of cancer. These enzymes are involved in the conversion of glyoxylate and dicarboxylate compounds into intermediates of the tricarboxylic acid (TCA) cycle, which plays a crucial role in cellular energy production. 26