Figure summarizes the experimental setup and reaction conditions for the desired Nbenzylacetamide (4) from benzylamine (1) and acetyl chloride (2) or acetic anhydride (3). A PTFE T-shape mixer (0.5 mm ID) was connected to a tubing (1 mm ID, 1.59 mm OD) and was immersed in a water bath maintained at 25 °C. A solution of electrophile 2 or 3 (X equiv) in solvent and a solution of 1 (0.30 M, 1.0 equiv) and NaOH (X equiv) in water were injected independently into the T-shape mixer using TriContinent Syringe Pumps (controlled by lab automation software Flab 23 ). The resultant mixture was collected into an aqueous solution 1 M HCl in a vial for quenching the reaction. After dilution of reaction mixture, the yield of 4 was calculated using HPLC-UV analysis. To find environmentally and economically acceptable conditions for the synthesis of amide 4, we decided to maximize the space-timeyield (STY) and minimize the E-factor simultaneously. Experimental details can be found in Experimental section.