Herein, we present BODIPY-NODsa family of simply synthesizable NO photodonors based on meso-methyl-BODIPY core. We report the efficiency of NO photorelease, photoinduced 1 O2 generation and fluorescence quantum yields. The proportion of NO and 1 O2 can be tuned by introduction of substituents into the chromophore core, from the sole photorelease of NO with barely detectable 1 O2 to the opposite (no NO / high 1 O2). These compounds and their future derivatives are promising for the development of light-controllable smart therapies, including the photodynamic therapy of cancer.