Cellulose is one of the most abundant biopolymers and can be produced from many sources, including plants and bacteria (1). Cellulose nanocrystals (CNCs) are made from cellulose by selectively degrading the cellulose-disordered and amorphous regions using strong acids and oxidizers (1). CNC exhibits high crystallinity and hydrophilicity, robust mechanical strength, excellent biodegradability, low cytotoxicity to a range of animal and human cell types (2) and favorable interactions with cell lines (3). These characteristics made CNC an ideal candidate for applications in biological systems (2), such as hosts for drug delivery (4, 5) and cell-supporting scaffolds for culturing or tissue engineering . In addition, incorporating magnetite nanoparticles (MNP) into the nanocellulose networks helps expand the applications and better realize some existing functionalities . CNC-Magnetite nanoparticle nanocomposites have been demonstrated as contrast agents for magnetic resonance imaging . MNPs were also found to promote the differentiation, proliferation, and growth in certain types of cells when present in scaffolds or loaded into cells (13 -16). Studies have demonstrated that applying an external magnetic field offers positive effects on cells (13 -16), however, even without an applied magnetic field, the incorporation of superparamagnetic magnetic nanoparticle impacts cell behaviors and the bioactivity of the scaffolds in beneficial ways .