Toward this goal, we concluded that a metric derived from the number of characterized compounds generated through virtual skeletal edits would be more useful for analyzing the potential benefit of each transformation. This metric is less affected by transformations that generate more products than there are starting materials. However, the absolute number of characterized products a transformation generates cannot be used directly, since this absolute number is limited by the total number of characterized molecules of the same heterocycle type in the starting dataset. As such, we cannot derive an accurate representation of the percentage of the products a transformation generates that are characterized by subtracting the percentage of those products that are uncharacterized from 100%.