Our interpretation is in line with recent Martini 3 simulations by Cabezudo and co-workers of membrane self-assembly in the presence of a TM helix dimer. In those simulations, the dimer was effectively excluded from the membrane upon selfassembly. The dimer did remain transmembranar if inserted into pre-assembled membranes, though this is likely to simply reflect a slow TM-to-adsorbed kinetic (in this regard, the simpler WALP systems are advantageous in that ejection events can be observed in the 10 0 -10 2 µs scale).