From these results, we showed that one can perform targeted substructure conversion in a desired direction by specifying the direction of change in advance based on the MMP analysis results, and using the difference matrix of Morgan fingerprint that matches it. We show an example of this for LogP improvements in Figure . We think that this method has many advantages, such as not requiring to specify the conversion sites of substructures in advance, and having high synthetic feasibility because it is based on the conversion examples of compounds that were synthetically possible in the past. We think that it is a highly practical model for drug discovery. In addition, we think that the applicability of descriptors will expand greatly when it is possible to directly design compounds from results of descriptor calculations, such as analyzing important bits by random forest and reproducing compounds from them.