One group provided a total of 13 different CB8 prediction sets based on MD free energy calculations with parameters from a force matching (FM) protocol as previously applied in SAMPL6; some of their prediction sets, including their best ranked set of predictions, then used reweighting to re-evaluate free energies with a quantum mechanical energy function. The best approach (which was also the ranked approach) in this case used force-matched PM6-D3H4 parameters for the CB8 guests (DDM/FEP/MBAR/FM/[pm6pm6]), and yielded an RMS error of 2.46 kcal/mol. This suggests that hybrid approaches involving MDbased simulations with QM reweighting may now be able to achieve some measure of success.