Butamben is a topical local anesthetic which formulation in lipid-based DDS is difficult due to its affinity for hydrophilic solvents, which are not miscible with cetyl palmitate, the solid lipid. This indicates that a medium polarity excipient should be used as the liquid lipid, and its miscibility with the solid lipid should be evaluated. The mixture of cetyl palmitate:Capryol ® 90 proved to be more suitable than the mixture of cetyl palmitate:Dhaykol 6040 LW, but the amount of butamben that could be added was still low. Therefore, the use of other excipientsespecially the solid lipidcould be interesting, however this was not the goal of this study.