Amongst the different potential strategies, the B-alkyl Suzuki-Miyaura cross-coupling (SMC) reaction (Scheme 1A) presents a powerful method for creating C(sp 3 )-C(sp 2 ) bonds through the coupling of alkyl borane compounds with aryl or vinyl (pseudo)halides. Notably, it offers advantages such as the mild and facile generation of the alkyl borane coupling partner (e.g., via hydroboration), great functional group tolerance, manageable toxicity of boron-derived by-products, and the ability to perform the reaction under non-dry conditions. However, several limitations, including the requirement for expensive and/or sensitive organometallic compounds, high temperatures, and long reaction times, hinder the practical utility of these transformations in routine medicinal or process chemistry applications. Consequently, the development of mild and selective B-alkyl SMC reactions becomes an attractive option to facilitate access to three-dimensional structures.