CASP (Computer-Aided Synthesis Planning) tools constitute modeldriven approaches to navigating the corpus of reaction data and have proven to be able to predict retrosynthetic routes even for completely new compounds. The usage of these tools can be considered complementary to the conventional construction of synthetic procedures via iterative database searches. The experimental reaction data available from the literature, from electronic lab notebooks, etc... can be arranged in a network in which sequences of chemical reactions are linked through common molecular intermediates, generating the so-called Network of Organic Chemistry (NOC) . The NOC is often instantiated as graph databases to leverage graph arithmetic for unconventional search procedures, such as extracting chemical routes . This arrangement of the data allows scientists to efficiently navigate the preexisting knowledge and to enrich it by identifying new potential routes for known target compounds.