The bulky structure of COSAN contrasts with the structures of classical intercalators or groove binders. COSAN has a peanut-shaped, 11-Å-long, and 6-Å-wide structure , whereas the distance between adjacent base pairs in the B-form DNA helix is 3.6 Å and the minor groove of DNA is 4.8 Å wide. Although, DNA is flexible enough to accommodate bulky molecules (e.g., DNA can unwind to enable steroids to intercalate) 62 , the DNA structure shows no changes in UV-Vis, CD, LD, and viscosity measurements suggesting COSAN binding.