Inclusion of ADP polarizability in the embedding model further reduces the RMSE errors with respect to the DFT/MM result (Figure ). The effect of the induction energy is more perceptible for the Δ-ML for ADP, which provides a better description of the in vacuo potential. A larger error of the underlying ML potential can mask errors in the embedding model by means of a partial error cancelation. The inclusion of the induction term is important, in principle, because it can vary greatly between different configurations (even for ADP, where the changes in the interaction between the solute and the solvent are not too drastic). In contrast to the charges used to calculate the static part of the embedding energy, which depend solely on the solute's geometry, the induction component depends also on changes in the environment. When comparing the static and total EMLE embedding energies obtained for the ADP configurations sampled to the DFT QM/MM embedding energies (Figure ), the EMLE model correctly describes the total interaction energy and the contribution of polarization. A nearperfect correlation between the EMLE and QM/MM embedding energies is also maintained when the induction energy term becomes larger, i.e. for those configurations with a larger solute-solvent interaction. It must be stressed that an embedding model describing polarization correctly is essential to discriminate the interaction of a solute (or small molecule) with different environments, for instance for the evaluation of free energies of binding or transfer. It can also be particularly important in metalloenzymes, where the substrate-metal interaction and polarization can be very intense. An important example are ATPases, enzymes in charge of hydrolysing ATP, that must bind Mg 2+ and ATP, two highly charged species. The correct description of the interaction between these two ions requires the inclusion of polarization effects. Although more research is clearly needed, the EMLE embedding model is a promising tool for the correct description of these difficult cases.