Further comparison against a wider range of restraint schemes over a variety of systems is also the subject of future work. In summary, this work demonstrates that absolute binding free energies equivalent to those obtained with Boresch restraints can be calculated using multiple distance restraints. This framework is in principle more stable and may offer convergence benefits during decoupling, although this must be balanced against the additional computational cost incurred by the extra stages required for the rigorous schemes. However, a multiple distance restraints scheme utilising many flat-bottomed potentials to closely restrain the ligand with minimal disturbance of the interacting system may allow the restraining stage to be neglected, as with the DBC restraint, while improving the convergence of the decoupling stages when the ligand is flexible. This work discussed the theory and demonstrated proof-of-principle of rigorous multiple distance restraint schemes; future work may investigate whether the scheme can offer performance benefits.