06) Metabolic engineering of the paclitaxel anticancer drug. Oudin, A., et al. The paper in question makes significant advancements in understanding and engineering the biosynthetic pathway of paclitaxel, a complex diterpenoid natural product produced by yew trees (genus *Taxus*). Paclitaxel is a vital anticancer drug used globally, but its natural production is limited and extraction from yew trees is not sustainable. The key advancements accomplished in this paper are: