Small molecules that bind the E3 ligase CRBN are the most investigated molecular glues. Besides them, there are other molecular glues that induce protein degradation through various mechanisms of action, including autophagy mediated protein degradation. A selection of promising E3 ligase molecular glues, non-E3 ligase molecular glues, and natural molecular glues are examined below. More detailed information on these molecular glues is listed in Supplemental Information Table .