In contrast to the work of Flejszar, we have to use a dedicated reducing agent because SPMA does not have intrinsic reducing properties like DMAEMA does. In this article, we present the process and results of adapting and optimising Flejszar et. al.'s method of SI-ARGET-ATRP under a coverslip to 3-sulfopropyl methacrylate (SPMA), a anionic monomer that yields strongly hydrophilic polyelectrolyte brushes. The Design of Experiments (DoE) principle is employed to systematically vary various parameters, with the goal of determining their effects, and ultimately, finding the optimal conditions.