While the mapping for our Martini 3 cholesterol model is inspired by the Martini 2 version , some substantial modifications were done to the bead layout. These modifications were made possible due to the most recent iteration of the force field allowing for mappings finer than 4-to-1 16 , which was not previously possible, at least not in a systematic manner . Bonded parameter distributions for the model can be found in the Supplementary Figure .