The tablets were prepared based on the experimental design. Physical mixtures of SPIONs, celecoxib (Mw = 381.4 g mol -1 ), PVP (Mw = 2000-3000 g mol ) and magnesium stearate (0.5 wt%) (Mw = 591.3 g mol -1 ) were prepared using mortar and pestle. Celecoxib and magnesium stearate were purchased from Fagron Nordic A/S (Denmark). Kollidon 12PF (PVP) was a kind gift from BASF (Germany). From the physical mixtures, 50 ± 2 mg flat-faced tablets (Ø 6 mm) were prepared using an instrumented single punch tablet press GTP-1 (Gamlen Instruments, UK). The tablet press was fitted with a 500 mg load cell (CT6-500-022) and used at a compression pressure of 160 MPa. The tablets and the mixtures were stored in airtight containers until further use.