In a 150 mL oven-dried round-bottom flask with a stirring bar, was added 2,4,6trichlorophenol (1.18 g, 6.00 mmol, 2.5 equiv) under nitrogen atmosphere. DCM (60 mL, 0.1 M) was added into the flask and the reaction mixture was cooled to -40 °C. ZnEt2 (1.0 M, 6.0 mL, 6.0 mmol,2.5 equiv) was added slowly into the flask by syringe and the reaction mixture was stirred at this temperature for 15 min. CH2I2 (2.6 g, 9.6 mmol, 4.0 equiv) was added slowly by syringe and the reaction mixture was stirred at this temperature for another 15 min. Next, the corresponding solution of 4-ethoxystyrene (0.36 g, 2.4 mmol, 1.0 equiv) in DCM was added by syringe and the reaction mixture was allowed to warm to room temperature and stirred for 16 h. After the reaction reached completion (as judged by 1 H-NMR), the reaction mixture was quenched with sat. NH4Cl (30 mL) in 30 minutes and extracted with DCM (100mL) for 3 times. The combined organic layers were washed with aq. NaOH (1.0 M, 30 mL) and brine (20 mL), dried over Na2SO4 (20 g) and filtered. The mixture was concentrated under reduced pressure, the crude residue was purified by column chromatography (Pentane: EtOAc = 50: 1 to 10: 1) to afford the desired compound . HRMS (APPI/LTQ-Orbitrap) m/z: [M] + Calcd for C11H14O + 162.1039; Found 162.1038.