Resonance line broadening due to transverse relaxation is one of the key limitations to precise determination of multiple coupling constants in small molecules, or to the characterization of large biomolecules by NMR spectroscopy, due to the inability to satisfactorily resolve overlapping cross-peaks from multiple residues or spin systems. Many approaches have been developed to circumvent this problem including increasing magnetic field strengths ; non-uniform sampling (NUS) and spectral aliasing ; a variety of isotopic labelling schemes employing deuteration to reduce transverse relaxation rates ; transverse relaxation optimized (TROSY) experiments ; or, most simply, the use of window functions (apodization) to enhance resolution (at the expense of sensitivity).