In this Perspective, we humbly share our findings and understandings accumulated in the past three decades in developing the three-body coupling X:R-Y bond, from the standing point of Hamiltonian perturbation-driven bonding and electronic dynamics. As an amplification of the O:H-O, the X:R-Y must meet a certain number of criterion, be more generalization, follow certain regulations, and possess common characteristics, as detailed in subsequent sections. Therefore, the R is not limited to hydrogen.