1. E min ignores non-thermodynamic factors that affect synthesizability E min does not account for factors such as the precursors involved in a synthetic process, synthesis temperature and pressure conditions, and reaction kinetics. Thus, E min may not capture the nuances of different reaction mechanisms, leading to potential inaccu-racies when predicting synthesizability under specific conditions. Non-thermodynamic factors may even cause all isomers of a given molecular formula to be unsynthesizable, including the lowest energy isomer with E min = 0. Thus, exploring ways to combine E min with non-thermodynamic synthesizability descriptors could lead to more accurate synthesizability predictions.