Aryl "onium" reagents have emerged as aryne precursors during a resurgence of methods based on orthodeprotonation/-elimination (Scheme 1b). These aryne precursors include those based on halogen leaving groups such as iodonium, bromonium, and chloronium, as well as chalcogen leaving groups such as sulfonium and oxonium (Scheme 1b). In several cases, these "onium" leaving groups permit the use of mild bases such as potassium and cesium carbonate and potassium phosphate to generate arynes, and these approaches rival or even exceed the functional group compatibility of fluoride-induced aryne generation of otrimethylsilyl triflates. Although aryl "onium" reagents have provided a mild way to generate arynes via deprotonation, they have not universally improved the generality and efficiency of accessing arynes. For instance, cyclic diarylhalonium salts specifically deliver biaryl-derived arynes and therefore lack broad generality. Additionally, triaryloxonium salts require a substantial time and material investment to synthesize similar to that of otrimethylsilylaryl triflates. Unsymmetrical aryl(Mes)iodonium and aryl thianthrenium salts are uniquely positioned within this class of aryne precursors to effect both mild and efficient access to arynes (Scheme 1b).