Students were divided into small groups to solve problems of patient cases or biomedical phenomena and practice, and applying knowledge and skills . In Denmark, two young universities, Roskilde 65 University and Aalborg University (AAU) were founded in the 1970s, initiating the innovative PBL pedagogy . At AAU, the Aalborg Mode has been established, characterized by a syllabus of 50 % percent problem-centered project work and 50 % traditional lecture in an interdisciplinary research environment . The PBL approach is organized as group project work and is implemented from the first semester until the completion of the master's degree. Throughout the university program, the group 70 sizes generally decrease. Initially, groups typically consist of 6-7 students in the first year, gradually reducing to a maximum of 2-3 students in the final semester . Learning is thus organized around problems and naturally frames a student-centered pedagagy to drive the students to be autonomous learners. The other benefits for students include the potential to reach a high academic level in interdisciplinary areas, the development of the team-work capacity, and better preparation for the labor market. One special advantage of PBL is its great relevance to the practice of the project work, thus allowing students to move from theoretical knowledge to practical application seamlessly. Logically, PBL offers an excellent pedagogical platform for employing first principles thinking to enhance students' learning and their capacity to solve real-world problems .