Various secondary alcohols were then investigated (Table ). The reaction was also found to be applicable to a wide range of different secondary alcohols, when 2-hydroxyindan was used in this reaction, the target product (65) was obtained in 50% isolated yield. On the other hand, 1-hydroxyindan and 1,2,3,4-tetrahydro-1-naphthol, which have an alcohol at the benzoivc position, gave the target compounds in lower yields (66, 67). The deoxygenative Giese reaction also proceeded with substrates such as cyclohexanol, cycloheptanol, and cyclooctanol (68-70). Further investigation of the range of substrates for this reaction demonstrated that the desired compounds could also be obtained by coupling secondary alcohols with styrene (41) (71-74). In addition, the reaction was also applicable to steroidal skeletons, which have a variety of biological activities and are important for drug development (75, 76). It is worth noting that compound 75 could be synthesized on a gram scale. Finally, we confirmed the substrate applicability of the present reaction to heterocyclic compounds, which are extremely important building blocks in the field of medicinal chemistry and found that the reaction was applicable to a wide range of compounds (77-83). These results indicate that this reaction can introduce a wide range of Michael acceptors to a variety of primary and secondary alcohols (Tables and).