(4) The transcription factor domain glides to a specific DNA transcription factor binding region. By identifying the replicon, the tau protein locates the DNA replication origin and subsequently unwinds the double helix DNA using the helicase. Through DNA polymerase activity, tau protein glides onto the unwinding DNA sequence. The transcription factor domain binds tau protein to specific DNA transcription factor binding regions, including development, stress response, response to stimulus/stress, sex determination genes, meiosis, interferon, heat shock, cell differentiation, cell cycle, cell migration, cell proliferation, cell apoptosis, and angiogenesis.