Double hydrophilic copolymers (DHCs) are defined by consisting of two distinct hydrophilic blocks of different chemical nature. Nowadays the material class of DHCs has a broad application range starting from drug carriers to gene delivery or as sensors, nanoreactors, or for the synthesis of multifunctional hybrid materials. This wide range of applications can be explained by the possibility of precisely modifying the composition and topology of the underlying polymers. After Stille et al. published their work on the first linear double hydrophilic copolymer (DHC) in 1972, this polymer class was significantly extended, not only by using a broad variety of monomers but also in terms of various topologies, ranging from linear block copolymers, brushes, or macrocycles to well-defined star-shaped examples. Based on these architectural differences, the polymer properties differ significantly, and thus new possible applications can be explored.