Alongside concentration, the charge of the components is a critical parameter for adjusting hydrogel structural stability. For instance, electrostatic repulsion facilitated the even dispersion of Au NPs in a SF hydrogel, while interaction was at the basis of the successful encapsulation of positively-charged, curcumin-loaded liposomes in CS hydrogel. However, interaction of opposite charged material could also induce destabilization of the nano-objects.