Figures show the molecules with the two highest J(m)-scores found by GB-GA. These scores, 8.8 and 8.5, are slightly larger than the three largest values (7.8-8.0) obtained by You et al. using a graph convolutional policy network approach. The two molecules bear little resemblance to the molecules used to construct the initial mating pool. The molecules in the ZINC data set that are most similar to these two molecules have respective Tanimoto similarity scores of just 0.27 and 0.12 and corresponding J(m) values of 0.9 and -2.4 (Figure ). This indicates that the GB-GA approach can traverse a large distance in chemical space using relatively few (50) generations.