However, new host-guest binding data that are suitable for the SAMPL challenges are relatively sparse in the scientific literature, and most new host-guest data generated by experimental labs are published straightaway, rather than being reserved long enough that they can be used in a blinded challenge. As a computationally focused research group, we are keenly aware of the value of new data that can be held back long enough to run a blinded challenge, so we have developed the ability to synthesize and characterize new host-guest systems and have generated new host-guest systems with experimental binding data for use in SAMPL . When possible, we provide not only a binding constant that may be compared with computation, but also NMR data that bear on the conformation of the bound host-guest complexes, as these, too, can be used to assess the computational results.