Recently, the work by Pal et al have taken a prime step forward and successfully demonstrated cellular uptake and precise manipulation of these ferromagnetic helices in the congested intracellular space, which is a significant achievement for potential utilization of these tiny robots in future theranostics. However, due to the presence of strong ferromagnetic components of iron, stability of these nanorobots against magnetic agglomeration is a matter of serious concern. Once these nanorobots come closer in the presence of an external magnetic field, it may adhere to one another via mutual magnetic attraction. It is quite an arduous task to separate such robots even after turning off the applied magnetic field, primarily because of the relatively higher magnetic remanence exhibited by metallic iron. Efforts were significantly directed to functionalize the surfaces of these ferromagnetic helices with zinc ferrite coatings, which simultaneously reports much improved stability and hyperthermia efficacy . However, the possibility of a futuristic therapeutic vehicle exhibiting controlled manipulation is severely compromised, particularly because of the coating thickness which is non-uniform and exceedingly higher (~700-950 nm). Consequently, comes the need for a sophisticated nanovehicle which must be highly directional, can transport substantial cargo and perform the desired action at the diseased-specific site. In the present work, we have successfully fabricated SPIONs functionalized nanorobots (abbreviated as SPIONs-NRs), exhibiting excellent stability against magnetic clustering or agglomeration. Additionally, we have analyzed the various dynamical aspects of these nanorobots which holds immense potential as the nextgeneration therapeutic vehicle, demonstrating controlled maneuverability in the extracellular matrix (ECM) at relatively lower magnetic fields (<50 Gauss), accompanied by targeted release of hyperthermia-induced local heat at the single-cell resolution. The 2.8-3.0 m sized silica helices were fabricated using the standard glancing angle deposition technique (details available in Supporting Information). The helices were then functionalized with SPIONs using the microwave synthesizer (details available in Supporting Information). This system of nanorobots, with a random arrangement of magnetic moments on the silica surface is relatively new and carries great significance from the standpoint of analyzing the underlying physics of such a complex magnetic spin configuration. Previously, coating of thin films of ferrites were mostly conducted on these helices using microwave synthesizer, however, covering the entire silica surface with nanoparticles was never realized . The primary purpose for coating these helices with iron oxide nanoparticles is to render their surfaces superparamagnetic, a critical factor to ensure their stability against magnetic agglomeration. Furthermore, the SPIONs (US Food and Drug Administration approved nanomaterials for clinical applications) are reported to be highly biocompatible, exhibit relatively higher value of saturation magnetization and specific absorption rate (SAR) , which are essential prerequisites for advanced biomedical applications. The nanoparticles get firmly coated on the surface of a SPIONs-NR, as distinctly evident from Figure . The X-ray diffraction (XRD) in the inset clearly indicates the formation of iron oxide, characterized by the most intense (311) peak . The signature of (111) peak of gold is due its presence in the substrate. The thickness of the robots, or precisely, the width of the several layers of iron oxide nanoparticles on the silica helix, reported here is nearly halved (~300-550 nm) as compared to those stabilized by zinc-ferrite coating .