Highest scoring molecules from the GB-GA and GB-GB-MCTS searches Figure shows an example of how the maximum J(m) value evolves with each generation for 10 different GB-GA runs. While most of the runs have mostly peaked after about 20 generations the three best performing runs (Run 1, 6, and 10) show significant improvements between 30 and 40 generations, so running fewer than 50 generations cannot be recommended for J(m) maximisation. None of the runs increase J(m) significantly after periods of 20 generations with no or little change in J(m) (with the possible exception of Run 7). So a good strategy may be to terminate the GB-GA run if the J(m) value has not changed for more than 20 generations (at least for J(m) maximisation).