Taking these results into account, we are able to identify several potentially interesting lessons from the dissociation of adipic acid. First, the loss of ammonia creating protonated adipic acid suggests that dramatic changes in basicity can be caused by specific conformational motifs potentially found in atmospherically-relevant clusters as compared to bulk solution or larger particles. It is possible that this confinement-induced basicity effect could be common in both small clusters and, potentially, rough surfaces of small particles. Second, acid-induced reactivity may yield unexpected products in particularly acidic environments.