In this work, the outstanding catalytic performance in the selective hydrogenation of acetylene of [Pd(2-pymo)2]n MOF under industrial front-end conditions was reported. The decomposition of the MOF structure could be prevented by the immobilization on Al2O3 pellets. Also, the preparation of [Pd(2-pymo)2]n/Al2O3 eggshell catalysts vastly increased the catalytic performance, which is comparable to an industrial benchmark catalyst and even exceeds it in terms of ethane make. XPS and XRD analysis revealed a high catalyst stability even after 60 h long time experiments at competitive performance. Overall, the great potential of MOFs as single site catalysts is proven for this specific application and future work should emphasize industrially relevant reaction conditions especially taking into account stability and the performance for longer times-on-stream.