Figure displays an overview of fold-averaged performances, where strategies are paired with their baselines. Undefined metrics in edge cases were excluded. This mainly affected AU-ROC, where the number of proteins with metrics dropped around 25% for semi_resampling, resampling_before_clustering and no_resampling (Table of the Supporting Information). Figure brought the dilemma of direct strategy comparison with imbalance-sensitive metrics, which was especially apparent for the F1-score and its high baseline in no_resampling (quartiles: Q1 = 0.428, median of 0.611, Q3 = 0.756, Table of the Supporting Information).