targets that possess ≥ 100 Reference compounds (n=422). This treats Reference compounds on an equal footing by target but does not completely account for Clinical compounds that have multiple targets. In the kinase target class example, 329 Clinical compounds are compared with the median values for 122 single kinase targets having ≥ 100 Reference compounds. 3. Paired comparisons of all Clinical compounds versus the corresponding median values for their targets that possess ≥ 100 Reference compounds (n=1091). While this results in certain target values being duplicated (especially kinases), if reflects the reality that some targets have been pursued more than others. For those Clinical compounds with >1 target, medians of the targets' median NP property values were used. In the kinase target class example, 329 Clinical compounds are compared with the 329 median values for their annotated targets having ≥ 100