Diversity wise, the dataset contained 31 unique halides and 32 unique nucleophiles, encompassing amine, amide, aromatic nitrogen, and alcohol nucleophiles, and 29 unique reacting halidenucleophile pairs. Interestingly, the nucleophiles were less diverse than the aryl halides, owing to the nature of the ongoing campaigns at the time (Fig. ). It was also found that aryl bromides made up the majority the reactions, both in number of unique reacting pairs and total number of reactions (Fig. ). It was expected that HiTEA on the Buchwald-Hartwig dataset without accommodating for this overrepresentation would reveal an HTE reactome significantly centered around aryl bromide couplings. Indeed, HiTEA credits significant variable importance to BrettPhos Pd G1 (Fig. ). This is clearly not in agreement with the literature's reactome in which many ligands show equal or better general performance to BrettPhos . Thus it was hypothesized that a more nuanced analysis would arise if HiTEA was be applied to subdatasets (i.e. ArBr + 1˚ amine, ArCl + 1˚ amine, etc.), to determine their subreactomes. Subdatasets with more than 80 reactions and two or more unique reacting pairs were analyzed, as these subreactomes were more likely to be differentiated from their literature chemical reactomes.