The order of population of cavity-cavity contact minima: w-ua-ta>w-ua~w-ta> w for Garcia force field. In the case of Netz force field, the order is w-ua-ta~w-ta> w-ua> w. The peak intensity of contact minima is lowest in water in comparison to other mixtures. Therefore, the cavity creation is easier in water than w-ua, w-ta and w-ua-ta mixtures. Similar trend is observed using Netz model. We disclosed that cavity creation in urea-water mixture is difficult than in water. Similar results were previously reported. The peak intensity of contact pair is highest in water-urea-TMAO mixtures for both force fields which suggest that cavity creation is most difficult in water-urea-TMAO mixtures. For Netz model, the population of CP in water-TMAO mixture is comparable to water-urea-TMAO mixture and bit higher than water and water-urea mixtures. Therefore, cavity creation is more difficult in water-TMAO mixture as TMAO is more hydrophilic in nature. Contrarily, the peak intensity of contact pair in water-TMAO mixture is similar to water-urea mixture and lower than water-urea-TMAO mixture for Gacia model of TMAO. Thus, cavity creation is easier in water-TMAO in comparison to water-urea-TMAO mixture possibly because Garcia TMAO is not so hydrophilic. So the cavity association in TMAO solution is very much dependent on the choice of the force-fields of TMAO.