At the heart of these issues is the uncontrolled leakage of chemicals to the environment, via GHG emissions to the air and products to land, waterways and marine environments . This leakage has adverse effects on climate, biodiversity, ecosystems, and human health. Safeguarding planetary boundaries requires a transition towards more sustainable production and consumption of chemicals, where leakage is eliminated or made harmless to the environment and emissions are reduced across all lifecycle stages .