Light sensitivity has also been implemented to polymer prodrugs from the "grafting through" method already sensitive to endogenous stimuli, to improve drug release efficiency. For methacrylate, 184 in order to increase its short half-life (~2 min) via the design polymer prodrugs (Figure ). The redox-and light-responsive prodrug monomer was polymerized from a POEGMA macro-RAFT agent to achieve diblock copolymer prodrugs able to form nanoparticles of 135 nm in diameter upon self-assembly (Figure ). It was shown that prodrug activation successfully occurred in vitro following two different pathways: (i) high GSH levels (GSH dependent pathway) triggered the release of MTIC by thiol/disulfide exchange followed by tandem reactions, inducing decaging of MTIC, or (ii) under low GSH levels (GSH independent pathway), visible light (LED 405 nm, 40 mW.cm -2 ) induced release of MTIC via homolytic disulfide scission, followed by tandem reactions and MTIC decaging (Figure ).