Amprenavir, Indinavir, Lopinavir, Nelfinavir, Ritonavir: Five antivirals (Amprenavir, Indinavir, Lopinavir, Nelfinavir, Ritonavir) have been predicted that their original pocket is similar to COVID19 replicase pocket and they have passed the general docking filter. All of the antivirals that predicted to have similar pockets in the replicase-transcriptase complex passed in general docking except for acyclovir. Of these only Lopinavir and Ritonavir have clinical trials going on for them. In this study, Ritonavir was predicted to bind ORF1AB POLYPROTEIN (Nsp 12) and Lopinavir bind to ADP RIBOSE PHOSPHATASE (Nsp 3) which make sense because these two drugs used in combination, they target different proteins.