Examining the timing data for these large supramolecular complexes (Tables and), it is clear that the cost can be reduced substantially by trimming the diffuse functions. For coronene dimer, the change from def2-QZVPD to def2-ma-QZVP is accompanied by a 0.3 kcal/mol (or 1%) increase in the interaction energy and a 2× speedup. The change from def2-TZVPD to def2-ma-TZVP also changes the interaction energy by 0.3 kcal/mol and also results in a 2× speedup. The "sweet spots" for this system would appear to be def2-TZVPD or jun-cc-pVTZ, for which the interaction energies are within 1 kcal/mol of the def2-QZVPD result but the cost is less (in either case) than that associated with def2-ma-QZVP. As applied to the DNA-ellipticine complex, these same two basis sets appear to afford converged results, to the extent that we can tell without prohibitively expensive quadruple-ζ calculations.