This has been eliminated by starting the curves at ligand score 5 and 10 in P197 and S197. Some of the docked ligands in S197 from ranked 1 to 10 are quite different on average than the rest, and the first 4 poses on P197 are not locally close by nor in the cavity (previous section). c. S197 running average from ranked ligand #1 and using the reference epitope of P197 ligand 5.