In our dataset, by keeping track of whether the E3 ligase ligands have scientific literature or patent provenance, we have tried to analyze possible differences under this aspect (Figure ). As expected in patent literature, the chemical diversity and/or complexity is higher. For all nonsignificant pharmacophoric features, comparisons of the boxes indicating 95% percentiles are clearly close to one another, while for seven out of ten there are significant differences, suggesting that the latent patent pharmacophoric space is in some aspects different from published one. Evolvus's liceptor subset with compounds manually selected from patents surely enriched the general dataset of E3 Ligase binders we used. Some molecule examples from the same E3 ligase selectivity but different chemical space is given in Figure .