These consideration to develop and select a NM synthetic methods are especially important when it comes to the design of optimized NMs for catalysis . Detailed studies and control of a nano-catalyst (NC) properties require strategies beyond active site design : Not only reliable protocols and NC testing must be implemented , but the synthetic methods of the NMs and the post-processing or conditioning (e.g. supporting steps for heterogeneous catalysis) must be carefully controlled and thought through to ultimately fully understand what makes an efficient NM.