Recently, Marbach et al. establish a general model to describe the "transport and dispersion across wiggling nanopores", which is primarily activated by thermal process and occurs in a variety of different materials, with differing effects on diffusion properties. Although this global vibration-induced diffusion enhancement in nanochannels might in principle also allow for separation of solutes as a function of their own Peclet number, diffusion enhancement dictated by local stimuli-responsive dynamic molecular species in artificial systems remains largely unexplored. In fact, biological systems frequently manipulate transport properties by local dynamic mechanisms beyond the activated processes of pore shape agitation. Transmembrane diffusion is often facilitated by enzymatic molecular machines (MMs) that allow to transport against a concentration gradient with unprecedented efficiency and selectivity. The combination of local and global dynamic mechanism to impact transport properties, as employed in biological systems, is expected to drastically enhance properties of artificial nanomaterials. Inspired by natural systems, chemists have successfully produced artificial MMs that can act as artificial muscles and also be bound to and open membranes for diffusion of guest species. However, only a few examples show that these dynamic molecular systems can enhance diffusion in solution and the actual effects, as well as their origin, are currently controversially discussed. Similarly, for the dynamics of nanoscopic swimmers. Instead, controlled rotational motion by MMs in porous systems is expected to enhance diffusion due to confinement effects. Recently, Danowski et al. reported on the incorporation of 2 nd generation light-driven MMs in the backbone of a porous metal-organic framework. They demonstrated that the unidirectionality of rotation is maintained and that the immobilized motors exhibit rotational frequencies similar to the motors in solution. This is one of the few ex-amples of artificial MMs employed in ordered porous solids and the only example that illustrates regular spatial organization of unidirectionally rotating molecules in a porous crystal.