For both SCAN and ωB97X-V, tight clustering and alternating signs for the errors persist in higher-quality grids including SG-3 and EML(99,590). In contrast, when SG-2 is used errors at the MBE(5) level appear to be almost random for different cluster geometries, sug-gesting MBE(n) results computed using meta-GGA functionals are dominated by grid error when SG-2 is used. Notably, grid-dependent of this magnitude are not observed in conventional supramolecular calculations. For example, noncovalent interaction energies (∆E int ) for the S66 data set, computed at the ωB97X-V/aug-cc-pVTZ level, differ by an average of only 0.03 kcal/mol for SG-2 as compared to its unpruned (N r = 75, N Ω = 302) counterpart. Thus, SG-2 may be considered effectively converged to the grid limit for conventional, monolithic DFT calculations but the same grid is insufficient for DFT-MBE(n), where ∼ 10 4 subsystem calculations (or more) might be required to evaluate a single-point energy.