With these considera`ons, this paper will inves`gate an integral part of sample prepara`on, the milling of flower. The first ques`on was if the specific method of how to mill flower has a significant effect on the measured cannabinoid concentra`on. And secondly, if the results from different milling methods are comparable, would certain methods offer op`miza`on poten`al in other aspects, for example cost reduc`on, sample throughput or cross contamina`ons.