QUBEKit is a largely Python 3.6+ based force field derivation toolkit for mac and Linux operating systems. By combining multiple open-source bioinformatics and quantum chemistry packages into a single workflow, it is possible to generate bespoke force fields for molecular dynamics simulations (Figure ). QUBEKit can be run using only Anaconda or PyPI installable open-source packages, with the option to use Gaussian for QM and torsion optimisations, and the fortran package Chargemol for atoms-in-molecule analysis.