The resulting heterogenous mixture is wet-milled. The previously obtained distillation residue is filtered through charcoal and added to the milled phosphate mixture rinsing forward with additional 2-MeTHF (198 kg, 0.86 X). To the vessel is then added regulatory starting material MR84914 (120 kg, 0.52 X, 1.09 equiv.) and the mixture is degassed with nitrogen. To the vessel is added (R)-BINAP (11.3 kg, 0.049 X, 0.040 equiv.) and Pd(OAc)2 (2.05 kg, 0.0089 X, 0.020 equiv.) under nitrogen protection and the resulting reaction mixture is heated to 75-85°C. The reaction is considered complete when residual MR84910 relative to MR84915 reaches not more than 3.0% or not more than 10.0% after reaction for 30 hours. The reaction mass is then cooled and to the vessel is charged purified water (1150 kg, 5.0 X) while maintaining a batch temperature of 20-30°C.