Determining the metabolic profiles of new chemical structures is a fundamental step in drug discovery, as it significantly impacts the pharmacokinetic properties and overall therapeutic potential of compounds . Chemical entities can generally be divided into those that undergo rapid metabolism and those that exhibit slow biotransformation. Rapid metabolism reduces the exposure of the parent compound, often resulting in the formation inactive, or even toxic metabolites. In contrast, high metabolic stability can increase the risk of drug-drug interactions and may lead to toxicity caused by the accumulation of the parent compound .