Diseases often affect the biomechanics of renal tissues, complicating both the condition and its treatment. For example, DN alters the biomechanical properties of the glomerular basement membrane, affecting its filtration efficiency . Therapeutic interventions need to consider these changes to restore both biochemical and biomechanical homeostasis effectively. The interplay between biochemical disease mechanisms and treatment interventions has profound effects on tissue biomechanics. For instance, angiotensin-converting enzyme inhibitors used in DN treatment reduce proteinuria and hypertension by modulating chemical transport and reaction pathways . These treatments also impact the mechanical properties of renal tissues, thereby influencing their response to physical stressors and further disease progression.