Analyses of the potency vs. helicity data for N-Myc73-94 based peptides (Fig. , Table ) revealed that the mal constrained analogue for the N-Myc73-94-E86C/S90C series is the most potent, despite little difference in helicity relative to the other variants. For N-Myc73-94-N85C/G89C variants, a clearer correlation is observed with both the free-thiol (red) and disulfide bridged (ox)