The reactions in the Grambow et al. data set involve relatively small molecules, often with functional groups not usually seen in organic chemistry. We thus test our methodology on two reactions, one unimolecular and one bimolecular, that are more representative of those encountered in synthetic organic chemistry, with the goal to simply check whether the correct products can be found with the current parameters. The unimolecular reaction is a multi-step triple ring-closure (Figure )-an important step of the synthesis of Berkelyone A reported by Elkin et al. We locate a possible mechanism for the path to the observed product through the five steps, together with other known biproducts. The bimolecular reaction is the acid catalyzed syntheses of benzimidazole derivatives starting from ortho-phenylenediamine and benzoic acid (Phillips method) , where we find all five steps in the generally accepted reaction mechanism. The meta-MD hyperparameters used in this study thus appears to be generally applicable to finding low-barrier reactions.