Veber's rule is associated with drug bioavailability through topological polar surface area (TPSA) and the number of rotatable bonds (#RoB) . In this dataset, most compounds conformed to these criteria (Figure ). Structures that do not comply with drug-likeness criteria are polyphenol antioxidant and fatty acids showing IC50 values greater than 10 μM, considered inactive in STADS. Additionally, relevant descriptors like molecular refractivity (MR) with 𝑥̄= 99.62 Å 3 /𝑚𝑜𝑙 correlated with molecular size , molecular complexity which is related to the number to stereocenters, fraction of sp 3 carbon (CSP3 fraction), selectivity and promiscuity (Méndez-Lucio & Medina-Franco, 2017) had relative high mean value of 𝑥̄= 0.77 compared with 𝑥̄= 0.69 of FDA-approved drugs retrieved from DrugBank . Shape index (SI) aligned with the PMI plot, suggesting a balance of branched and linear structural features . Further analysis of the CSP3 fraction revealed a notable presence of aliphatic carbons, frequent heteroatoms, and amide bonds. Moreover, 40.55% of the compounds contained at least one HBD group, an important feature exemplified by the inhibitor 2 (Figure ) that forms key interactions with Tyr152 in the S. aureus FabI active site. Overall, these descriptor analyses integrate drug-likeness criteria for bioavailability and permeability with structural features-ring systems, heteroatoms, polarity, size, and shapecommonly observed among the inhibitors.