We then investigated the formation of carboxylic acids from various alcohols through oxidation catalyzed by gold nanoparticles under the same reaction conditions as the enzymatic step. In addition to using butanol (1a) as model substrate, we conducted reactions with pentanol (2a), hexanol (3a), octanol (5a), 2-phenylethanol (7a) and 1,4-butandiol (11a)(Figure ). These alcohols were chosen because their corresponding carboxylic acids are substrates of TsACL, the selected enzyme. Consistent with our previous study, we achieved excellent conversion into the corresponding acids for all the aliphatic alcohols tested (91 % for 2b, 93 % for 3b, 88 % for 5b and > 95 % for 11b) as reported in 24). In contrast, we did not measure any conversion for the 2phenylethanol. Noteworthy, in the case of 1,4-butanediol, total oxidation of both carboxylic acids was observed showing the efficacy of our catalyst, and making it promising to produce dimers of AMFC-amides.