The aromatic ring of HCQ ensures the effective positioning favoring these binding with the RNA of SARS-CoV-2. With reference to an additional OH-group present in HCQ over CQ, its significance towards the interaction with RNA of SARS-CoV-2 is evident. Also, these actions of HCQ is aided by the combination of azithromycin, where ionic coupling agents like Mg 2+ , Ca 2+ , and Zn 2+ are involved. 60 However, the given studies had a limitation and did not comment on the adverse effect of QT prolongation. In this regard, Mercuro et al. showed a cohort clinical observation of QT prolongation among 90 patients having COVID-19 infection along with comorbidities like hypertension and diabetes mellitus after hydroxychloroquine and azithromycin intake. Such report makes it necessary to understand the risk to benefit assessment of co-administration of this combination for patients suffering from conformities especially with cardiovascular diseases. In a similar manner, ivermectin has been recently undergoing examination in combination with HCQ for COVID-19 as it acts synergistically with HCQ. Choo et al. in their report suggested the severity of disease due to non-availability of appropriate medication(s) apart from protective kits (measures). A huge shortage of HCQ has been observed owing to its high global attention across government agencies, healthcare professionals, patients, and the general public in the context of COVID-19 pandemic. Consequently, its misuse and overdose in COVID-19 patients and compromised (restricted) use in patients with rheumatoid and autoimmune disorders has been observed. Under such circumstances, the government bodies, and healthcare professionals must come up together in controlling the judicial and systematic use of HCQ for COVID-19 with proper emphasis on the urgency of evaluation of HCQ (CQ) to get more relevant clinical data showing the significance of HCQ (CQ) for the COVID-19 treatment. In this regards, amidst of ongoing therapeutic assessment of HCQ, the latest results published in Lancet (May 22, 2020) has shaken the proposed utility of HCQ for COVID-19 treatment.