We evaluated the impurity prediction pipeline for two commonly used drugs -paracetamol and ibuprofen . N-(4-hydroxyphenyl)acetamide, paracetamol or acetaminophen is one of the most widely used over-the-counter drugs in the world, with kilotons being manufactured every year . (RS)-2-(4-(2-Methylpropyl)phenyl)propanoic acid, Advil or ibuprofen is another commonly used over-the-counter drug, listed as one of the essential medicines on the World Health Organization list . These examples were chosen based on their simplicity, and being publishable as a part of the thesis, without any legal constraints.