(1) Ahneman et al. performed a focused Buchwald-Hartwig reaction screen on 1536-well plates, containing a full-factorial combination of 15 simple aryl halides, 23 additives, three bases and four palladium catalysts, with one aryl amine, one solvent, constant temperature and time. The HTE resulted in over 4300 data points. (2) The work of Perera et al. used a nano-and micro-scale continuous-flow reaction screening set-up and the authors performed more than 5700 Suzuki-Miyaura reactions using six aromatic organoboranes, four aryl halides and one triflate, 12 palladium ligands, eight bases and four solvents at constant flow rate, temperature and pressure. The scaffolds of the reactants remain the same throughout the data set, and the reactions result in only one product.