To assess differences in the dissolution profiles of all four excipients for ASDs containing 50wt% and 80wt% drug, respectively, dissolution experiments (under sink conditions) were conducted with the prepared extrudates (Figure ). Irrespective of the polymer used, samples and 15 min, respectively. The rather large error bars obtained for P2 at 50wt% may be due to incomplete mixing of the drug within the ASD. A similar trend between polymers regarding the drug dissolution rate can be observed for the samples containing 80wt% IND. The drug loaded samples containing P1 and P2 dissolved somewhat more slowly than the ASDs prepared with PVP and P(VP-co-VA), but the difference between the excipients is less pronounced and none of the samples reached a plateau with respect to drug release within the investigated time.