It is worth mentioning that the calculational and time costs for building ANN models are significantly lower compared to the development of a kinetics model in the traditional way which requires deep knowledge about mechanism of reactions and great expertise in making appropriate simplifying assumptions, and for the solving inverse kinetic task (Figure ). In To demonstrate this procedure of using the KCNEODE as intermediate model, we screened the literature for kinetic models to find the kinetic expression that is best matching the RWGS rate obtained by the developed KCNODE model (see the supplementary material).