We report X-H BDEs of amino acids in proteins computed using the isodesmic reaction method at the BMK/6-31+G(2df,p) 7 level of theory. We validate our BMK results by comparing the BDEs of smaller amino acids to results obtained at the G4(MP2)-6X 8 level of theory. The BMK functional was chosen because it has been shown to perform well for both, thermodynamics and kinetics of radical reactions. 9-11 G4(MP2)-6X is a composite method that uses BMK/6-31+G(2df,p) geometries and performs almost as well as G4 at lower computational cost. The G4(MP2)-6X energy is obtained as follows: