Drug Formulation. Drug-loaded polymer micelles were prepared using the thin film hydration method. Ethanolic polymer (20 g/L), curcumin (5 g/L), paclitaxel (5 g/L), R-IBU (5 g/L), S-IBU (5 g/L) or RS-IBU (5 g/L) stock solutions were mixed in desired ratio. After complete removal of the solvent at 50 °C under a mild stream of argon, the films were further dried in vacuum (≤0.2 mbar) for at least 30 min. Subsequently, preheated (37 °C) H2O (Millipore) was added to obtain final polymer (10 g/L) and desired drug concentrations. To ensure complete solubilization, the solutions were shaken at 55 °C for 15 min, at 1250 rpm with a Thermomixer comfort (Eppendorf AG, Hamburg, Germany). Non-solubilized drug was removed by centrifugation for 5 min at 9000 rpm (relative centrifugal force (rcf) 7788 g) by a MIKRO 185 (Hettich, Tuttlingen, Germany). The solubilization experiments were performed with three individually prepared samples and results are presented as means ± standard deviation (SD).