In analyzing all CH-p donors, some C-H groups (Cn) contribute favorable energetic contributions, while others (59%) have unfavorable interaction energies, (Supporting Information Table ). In contrast, the oxygen groups (On) have nearly exclusively (99%) favorable energetic contributions, with an average value of -1.6 kcal/mol, and therefore play a significant role in stabilizing CH-p interactions (Supporting Information Table ). This follows a consistent trend: the most favorable On contributions and the least favorable Cn contributions occur at positions with the shortest observed distances for each angle (Scheme 1 and Figure ). This behavior is driven for the Cn groups by a repulsive exchange energy contribution and for the On groups by a stabilizing electrostatic energy contribution (Supporting Information Figures ). Summing these to get the total Cn+On contribution, we observe a range of favorable local minima, which indicates that polarized CH-p interactions found in galactose-aromatic interactions contribute favorable energetics in a range of orientations.