The time required to achieve steady state in a simulated continuous-flow stirred-tank reactor with a dynamically operating catalyst increases orders of magnitude from the simulation with a static catalyst. As depicted in Figure , the considered A-to-B reversible catalytic reaction was simulated using Matlab to achieve steady-state reaction conditions in less than one second. However, introduction of dynamics immediately increased computational time to greater than a second for all conditions. In particular, computational time increased logarithmically above about 100 Hz such that simulations above megahertz-imposed catalyst binding energy waveforms required more than 10 4 seconds (~ 3.0 hrs).