Active molecules from the MAGL project containing a N -heteroaromatic handle for Minisci-type alkylation were filtered to 125 candidates with sufficient powder stock. In parallel, a unique list of all carboxylic acids available in-house at Roche as well as commercially from Enamine (Monmouth Junction, NJ, USA) were assembled and filtered to 211 acids (SI4.2) based on a high fraction of sp 3 carbon atoms and a molecular weight of lower than 230 g/mol. Using Minisci reaction templates for N -heteroaromatic rings, each of the 125 available project compounds were then virtually enumerated with all 211 carboxylic acids to yield 26,375 virtual compounds for processing through the multiobjective filtering funnel shown in Figure .