Between 2000 and 2019, one-hundred twenty-three commercial and public NP databases have been published. Among them, ninety-eight are still somehow accessible (online or under request access), ninetytwo are free access, and only fifty contain molecular structures that can be retrieved for a chemoinformatic analysis . Examples of the most representative open-access NP databases include: The Collection of Open Natural Products (COCONUT) which is a major repository containing more than 411,000 NPs collected from 50 open access NP databases. The Universal Natural Product Database is a compilation that tries to gather all the known NPs; it has more than 229,000 NPs. It is not yet accessible through the link in the original publication, nevertheless, it is contained and maintained on the ISDB website . SuperNatural Ⅱ database contains over 325,000 NPs, nonetheless, it does not provide a bulk download. ZINC database has over 80,000 NPs, approximately 48,000 purchasable. Moreover, it contains some NP databases that are no longer accessible through the link provided in the original publication, e.g., Herbal