In the present work, and following the methodology described in the selection of key proteins in Alzheimer's disease, 85 proteins were selected. Among these proteins, targets widely studied and validated as key in AD are included, such as acetyl cholinesterase (ACHE) 4 , beta-secretase 1 (BACE1) , Amyloid-beta precursor protein (APP) , Glycogen synthase kinase-3 beta (GSK3β) , among others. Supplemental Table shows the complete list of the selected AD key proteins, as well as the number of active, intermediate, and inactive compounds extracted from the ChEMBL database based on their pChEMBL value.