An analogous reaction with aliphatic (10-12), aromatic (13-17), and even heteroaromatic (18-27) aldehydes gave the needed 3D-shaped iodides in moderate to excellent yields. Various functional groups, -nitro, trifluoromethoxy, trifluoromethyl, nitrile, halogens, -were compatible with the reaction conditions. The protocol was not without limitations, however. We could not obtain products 28, and 29 with thiazole and triazole heterocycles, due to the formation of complex mixtures. Ketones could also be used as electrophiles instead of aldehydes. As a representative example, the reaction of alkene 8 with LDA/acetone followed by cyclization gave dimethyl-substituted product 30 in 81% yield. The structure of 30 was confirmed by X-Ray crystallographic analysis (Scheme 4). A reduction of 8 followed by cyclization gave iodide 31 in 58% yield. Interestingly, the cyclization did not take place at room temperature, and the reaction was performed under heating. Alkylation of 8 with MeI or BnOCH2Cl followed by reduction and cyclization gave disubstituted products 32, 33 in 59-64% yield (Scheme 4). From iodide 6 we also synthesized various bifunctional linkers for incorporation into bioactive compounds instead of the paradisubstituted phenyl ring. Saponification of ester 6 provided carboxylic acid 45 in 90% yield. The subsequent Curtius reaction afforded N-Boc iodide 46 in 87% yield. The structure of 46 was confirmed by X-Ray crystallographic analysis. Reaction of the latter with potassium acetate, followed by hydrolysis (via 47) and N-Boc acidic deprotection gave amino alcohol 48. Oxidation of the alcohol group in 47 gave N-Boc protected amino acid 49a saturated analogue of the para-aminobenzoic acid. The reaction of iodide 46 with NaN3 (via 50) followed by reduction of the azide group formed diamine 51. The reaction of iodide 6 with NaN3, the subsequent reduction (via 52), N-Boc protection and saponification gave another N-Boc protected amino acid 53. Curtius reaction of the latter provided N-Boc diamine 54isomer of diamine 51. The reaction of iodide 6 with sodium azide followed by extensive reduction of the intermediate azide with LiAlH4 gave amino alcohol 55. The structure of 55 was confirmed by X-Ray crystallographic analysis. Reaction of iodide 6 with potassium acetate (via 56) followed by saponification of the ester group and oxidation gave linker 57. Its structure was also confirmed by X-Ray crystallographic analysis. Worth noting that all syntheses depicted in Scheme 5 were realized on a multigram scale.