The high structural complexity of NAPROC-13 NPs, compared to other screening libraries, including those of generally diverse NPs, underscores its potential for use in virtual screening for hit identification in drug discovery projects. While the chemical space of NAPROC-13, as described by drug-type properties, is somewhat limited to areas associated with approved drugs, its extensive distribution across the NP chemical space characterized by structural features makes it a valuable resource for identifying potential candidates in drug discovery efforts, especially for exploring underrepresented areas of chemical diversity. This is further supported by our findings, where NAPROC-13 achieved higher NPL scores than other NP sets and approved drugs, demonstrating its significant potential in the field.