All of these complexes exhibit exothermic binding, with hosts β-CD and MGLab 8 -MGLab 24 showing ΔH values in the rather narrow range (-9.1 to -10.9 kJ/mol). All of the binding entropies also are positive and hence contribute further to favorable binding, though hosts MGLab 34-MGLab 36 exhibit relatively small entropy increases. A scatter plot of binding entropy vs enthalpy shows entropy-enthalpy compensation (Figure , blue points), with the higher-affinity hosts lying to the left (lower binding free energy) of the other compounds. The structural basis of the observed thermodynamics cannot be determined from these purely thermodynamic data, and we are not aware of prior studies reporting whether the guest's hydroxyl resides at the primary or at the secondary face. . Blue: methylcyclohexanol. Orange: rimantidine. Radius of each data point is proportional to binding free energy.