For the SAMPL8 host-guest challenge, we find that binding free energy predictions are more accurate for GDCC hosts compared to CB8. This was also the case in previous SAMPL iterations despite CB8 and TEMOA being featured in those iterations. Then, we discuss the results for ranked methods and identify the top performing methods, compare ranked methods with each other, and discuss success and/or failures of methods. Separately, we also compare all methods (including non-ranked submissions and reference calculations) to probe the sensitivity of results to changes in protocol and/or method.