long-lived radicals (though the later requires a high F act ). In contrast, pinanediol, despite also having a similar low Fact, cannot generate long-lived radicals suitable for application because its intermediate (Pin_Int1) is short-lived and undergo rapid scissile cleavage into the two alkenes (Pin_TS3CC, see Scheme S1). Compared to the conventional azoalkane mechanophore, camphanediol exhibits excellent thermal and UV stability. After heating at 80°C or exposing it to UV light for 10 hours, the NMR spectra of all three diols remained unchanged (see Figure ). This stability allows camphanediol mechanophore to be incorporated into the polymer materials using high-temperature or UV polymerization and endows the resultant material with superior stability, which can expand the potential applications of camphanediol mechanophore. In conclusion, a general procedure to identify or design mechano-reactive radical-type mechanophore was proposed, as what is shown in Figure . The existence of a "node" along the force transduction direction, which is literally a bond that cannot rotate freely, is believed to enhance the force effect. In fact, highly strained rings or intrinsically weak bonds is not a must for a considerably high mechanochemical reactivity. Following pre-screening guideline, those molecules with "node" were subjected to the EX-AFIR calculations to derive their F act . In our case, camphanediol and pinanediol, molecules with a bridged six-membered ring, were identified as a qualified mechanophore that can undergo reactions at a relatively low F act . These two are economical natural products, which means that they are relatively cheap, easily accessible, and no complicated synthetic processes are required. However, only mechanoradical with relatively long half-life is beneficial to the selfstrengthening materials. Here, the reaction path explorations facilitated by the EX-AFIR method were subsequently conducted for the plausible decay pathways of mechanoradicals derived from camphanediol and pinanediol. It then revealed that a 1,5-diradical intermediate, which is believed to have a longer half-life, is formed in the case of camphanediol. The relatively long-lived diradical species enables it to react with the monomers fed to the system, thus ensuring a good self-strengthening process. For pinanediol, two alkene molecules are formed rapidly following the radical decay channel.