There is an extensive library of biodegradable polymers available for NPs preparation whereas the vast majority belong to the family of polyesters, including poly(lactide) (PLA), poly(-caprolactone)(PCL), poly(trimethylene-carbonate) (PTMC), etc. . Block copolyesters are also known as drug carriers since copolymerization is a very beneficial tool that can remarkably change the material hydrophilicity. In this context, copolymers of PLA with glycolic acid (i.e., poly(lactic-co-glycolic acid), PLGA) were probably the most widely explored and they are already commercially available . However, despite their indisputable advantages, PLA and PLGA-based drug delivery systems also face a number of challenges such as initial burst release, incomplete drug dissolution, and enhanced lag time . Considering those facts, new types of biodegradable polyesters need to be proposed to overcome these limitations. Poly(butylene adipate) (PBA) aliphatic polyester is mainly used in industrial applications, for example as a building block of poly(butylene adipate-coterephthalate) (PBAT) commercially known as Ecoflex® (BASF), which is marketed as fully biodegradable plastic . Interestingly enough, PBA copolymerization with different comonomers also led to novel biomedical materials showing both biodegradability and good biocompatibility. They were already evaluated as drug delivery systems and performed in vitro release studies indicated controlled release patterns connected with both drug diffusion and polymer degradation, where the degradation profile was moderated by PBA content within copolymer structure. Other interesting components for the preparation of biodegradable PNPs are fatty acids (FA) as hydrophobic compounds naturally occurring in the human body which may retain hydrophobic drugs due to hydrophobic interactions. Dilinoleic diol (DLD) is a compound obtained via the dimerization process of linoleic/oleic fatty acids which is suitable for step-growth polycondensation since its encapped with two functional groups. Block copolymers based on DLD monomer have already been proposed in the literature as materials with potential use in many biomedical applications, including bone and tissue engineering or drug delivery systems but using poly(butylene succinate) (PBS) instead of PBA .