There are multiple domain functions that are active in the replication of the coronavirus and these domains are present in a protein designated as Non-structural protein 3 (nsp3) which is the largest protein in the coronavirus genome . 3C like protease (3CLpro) and Papain like Protease (PLpro) are two important class of proteases that are involved in the process of translation of the polypeptide from the genomic RNA to protein components that are required structurally or non-structurally for replication and packaging of new generation viruses The main protease in the SARS virus is the key enzyme for processing of polyprotiens of the virus. This has been the main target for antivirals in the past in SARS-CoV and we hypothesize that as this has high homology with the main protease of SARS-CoV-2, the same protein can be a target for anitivirals in this virus as well. It has been known that viral replication can be blocked by inhibiting this protein . The nonexistence of this proteins in humans makes it an even more attractive antiviral target as there can be no cytotoxity to humans.