In order to overcome energy barriers, metadynamics continuously adapts the potential energy along a few chosen degrees of freedom as the MD simulation progresses which in turn decreases energy barriers between different states. Thus, metadynamics biases the simulation to sample regions of the phase space not yet sampled. This can potentially enhance the sam-pling of the entire energy surface. However, metadynamics require some degree of intuition about the important degrees of freedom of the system.