Consequently, we can conclude that the presence of aluminum in biological media can not be considered an inert factor since it can affect the thermodynamic equilibrium of processes in which the production/scavenging of radicals takes part. The alteration of the proper balance of radicals in biological media due to the presence of aluminum could be behind some of the most important toxic effects of aluminum in biological media, as early hypothesized in the literature but often underestimated due to the non-redox nature of this exogenous metal, and the long-held prejudice to consider aluminum as an intrinsically inert agent in biological medium.