In this work, we introduce chemoenzymatic photoreforming as a process which combines enzymatic plastic degradation with photoreforming to evolve hydrogen gas from polycaprolactone (PCL) and PET, in the forms of films and nanoplastics, at near-neutral pH (~6-8) and moderate temperatures (25-65ºC) (Figure ). Chemoenzymatic photoreforming employs two different PET hydrolyses, Dura and LCC, and photocatalysts including Pt-loaded TiO2 (TiO2|Pt) and Ni2P-loaded carbon-nitride (CNx|Ni2P). The overall process produces H2 with high yields, surpassing some well-established systems using alkaline pre-treatment. Chemoenzymatic photoreforming can be performed in tandem or in an integrated system, where the two steps are compatible in a one-pot reactor. Furthermore, we demonstrate the utilisation of enzyme-treated plastic as feedstock for photocatalytic CO2-to-syngas (H2 and CO) production using a TiO2|CotpyP photocatalyst. Here, apart from reducing externally-purged CO2, we observe the possibility of converting CO2 generated in-situ (from overoxidation of pre-treated plastic) to CO. Finally, our techno-economic analyses for H2 production elucidated the economic, environmental and energetic advantages of combining enzymatic catalysis and photoreforming.