The most appropriated ligand for this work was selected among those leads identified with the seeSAR program and described before as one of the derivatives of the 2-[4,6-bis(2-hydroxyphenyl)-1,3,5-triazin-2yl] phenol (PubChem 135616181) . The double bonds of the triazine core of that ligand were substituted for single bonds to reduce their toxicity while maintaining low its docking-score. The resulting parent ligand will be called TTT, since it was absent from the main public data banks. TTT was selected as the parent star-shaped molecule due to its simple symmetric structure despite predicting a low dockingscore (~0.2 nM) to the α-helix inner-cavity of the wild-type (no stabilizing mutations) prefusion state of SARS-COV-2 6xr8 earliest used as a model .