Descriptor HeavyAtomMolWt calculates the average molecular weight of compounds while ignoring the hydrogen atoms. Across all three datasets, especially in the training and the external datasets, it can be observed that lower heavy atom molecular weights have negative Shapley values. Interestingly, the magnitude of negative Shapley values is higher than the positive Shapley values, indicating that the model finds lower molecular weights more important in classifying compounds as non-lysosomotropic.