The distribution of the Tanimoto similarity of the five-nearest neighborhood (5NN) was calculated by ECFP4 using the RDKit (version 2020.09.01) Chem functions . This was then compared with the Food and Drug Administration (FDA)-approved drugs, consisting of 2,503 compounds obtained from DrugBank (version 5.1.8), using canonical SMILES obtained through the same process for prepared compounds mentioned above as the input structure . The distributions were then assessed for significant differences using the Kolmogorov-Smirnov test. To achieve this, we utilized the stats.ks_2samp function from the Scipy (version 1.7.0) library with the alternative option set to 'two-sided.' For each compound, 5NN similarity was calculated using the Balk-Tanimoto similarity function in RDkit (version 2020.09.01) by averaging the similarity scores of the top five most similar compounds .