It is crucial that the degrading products of polymers must be non-toxic which can help to minimize any side effects, however it can also influence the local microenvironment, promoting osteogenesis (bone formation) and angiogenesis (blood vessel formation). Over time, polymer degrades, and new tissues start to form within the defect site changing its mechanical properties and ultimately replacing the polymer with healthy bone tissue allowing them to bear loads, which is critical for proper remodeling .