As a summary, in model compound 73, and the antibacterial drug Sulfadiazine, the replacement of the hydrogen atom with the MeSO2-substuent led to a dramatic decrease of lipophilicity by >1 logP/logD units. Reliable logP values could be obtained within a range of 1.0-3.0. logD (7.4): the experimental distribution coefficient in n-octanol/phosphate-buffered saline, pH 7.4. Reliable logD values could be obtained within a range of 1.0-4.5. clogP: the calculated lipophilicity. CLint: the experimental metabolic stability in human liver microsomes (µL min -1 mg -1 ). t1/2 (min): the experimental half-time of a metabolic decomposition in human liver microsomes. *Parameter should be considered as approximate due to the high stability of compounds.