Compound 5 reacts rapidly with phosphate nucleophiles, and treatment with the TBA salt of adenosine monophosphate (AMP) leads to adenosine-substituted TriMP (10) in less than five minutes with only minor impurities observed in the 31 P{ 1 H} NMR spectrum. This transformation is reminiscent of the Khorana 7 and Ludwig-Eckstein 23 reactions which append pyrophosphate to form a nucleoside substituted TriMP intermediate. However, the present reaction is markedly cleaner and more selective than those canonical reactions, whose difficult chromatographic separations have spawned decades of research. Additionally, this reactivity of neutral doubly zwitterionic 5 is in stark contrast to the slow reaction of the dianonic imidazole adduct of P2O5 with AMP to form diadenosine tetraphosphate. 17