This strategy involves initiating a reaction between a single plant extract and an ineffective drug known for treating the disease of interest. The process includes adding a reagent, which can be an inorganic/organic acid, alkali, or a catalyst, and modifying the reaction temperature conditions. For antibacterial applications, multiple plant extracts can be reacted with different inexpensive antibiotics. The antibiotic must be confirmed to be ineffective against resistant bacteria, as structural changes might otherwise reduce the effectiveness of the final product compared to the initial antibiotic alone. This method increases the probability of obtaining synergism in plant extract-antibiotic combinations from 33% to 66% at an antibiotic concentration of 100 μg/mL, and to 100% at 1 mg/mL. Validation using Piliostigma reticulatum extract showed that 0.1 mL of concentrated tetraoxosulphate (VI) acid in 2 mL of the mixture was sufficient to induce synergism against bacterial resistance.