CDK8/CyclinC complex is a potent oncogene and an attractive drug target. Schneider et. al performed a structure-kinetics-relationship study where they were able to both provide the crystallographic structures and characterize the residence times of a series of aryl-pyrazoles using a competitive displacement of a reporter probe designed to selectively target CDK8. This exemplifies a typical case of structure-kinetics study of a congeneric series in drug discovery. Additionally, the presence of crystallographic structures for each of the compounds in the series allows us to minimize the uncertainty of results due to compound placement (e.g. with docking) hence focusing on the ability of the method to correctly reproduce experimental results.