Combining spatial and temporal control to enable integrated reactions to occur will not only be more efficient over an iterative process, but may also lead to the development of new chemistry and novel products. Shown in FIG. , a hypothetical integrated catalytic system with spatiotemporal control is shown that will allow the efficient conversion of a starting material (gold square) to an intermediate (brown square). This intermediate can then be shuttled to another catalyst that incorporates the synthesized intermediate with a second reactant (green square). The second catalyst may also be temporally switched to a state where it is now active for the incorporation of a third reactant (blue square). This approach could be a general strategy to synthesize complex structures that are not accessible using conventional methods.