We describe the MDM algorithm introduced for general molecular properties. A conceptual illustration is shown in Figure (a). The present MDM searches for a functional molecule in the equilibrium geometry by optimizing the molecular species, as introduced in our previous MDM paper. However, the previous search algorithm is designed for energy-associated properties and is not necessarily appropriate for general properties. In this section, a common strategy of our MDM is first shown. Then, the algorithm of the present MDM algorithm is compared with that of Ref. 10. MDM designs the molecule with the desired property by optimizing a using the property gradient while suitably changing the equilibrium geometry. The calculations of and geometry optimization are performed using quantum alchemy during the design. The MDM algorithm introduced for general target properties is described in detail in the following.