Considering their merits, the field of applications of CSHNs extends beyond therapeutic applications. Since the hybrid character of these nanocarriers enhances their biocompatibility capabilities, when compared to polymeric or lipid-based conventional nanoparticles, the CSHNs are also widely employed for bioimaging . Today, clinical imaging modalities, such as magnetic resonance imaging (MRI) and computed tomography (CT), are approaches accepted as the gold standard in the diagnosis and evaluation of treatment efficacy of various diseases. Molecular imaging or bioimaging is concerned with the visualization of molecules of medical interest in patients. The probes specifically designed for each technique provide information about biological processes, which enables medical staff and doctors to diagnose medical conditions and diseases. Each probe consists of two components: a targeting component that transports the probe to the target tissue and a contrast agent that generates an image of the biomarker.