Furthermore, the cross-linking approach described herein can be easily transferred to other biocatalysts with high crystallizability that would typically be inactivated upon cross-linking with glutaraldehyde. Building on the variety of commercially available mono-and bi-specific crosslinkers, this approach should further allow crosslinking beyond the thiol functionality. Even the use of cleavable cross-linkers is conceivable, opening up a whole range of new possibilities for furture applications.