As a further demonstration of the capabilities of the method BAM-15, a mitochondrial uncoupler which functions as a proton transporter across the inner membrane , I now examined. BAM-15 is a mitochondrial protonophore which alters the EMF across the mitochondrial membrane during proton transport. It is an unusual molecule for several reasons: it is fully conjugated and any charge deposited on a ring (all being arene) will be distributed across it, it is 𝑍 2 symmetric, has a high number of hydrogen bond acceptors, and it has 2 amines rendered less basic by conjugation to fluoroarenes. It observed that it stimulates weight loss in mice without adverse effects and without degradation of the plasma membrane , unlike other mitochondrial uncouplers DNP or TFFB. Although effective in vivo in mice studies for weight loss, the molecule has too short a half-life to be effective, on the order of 1.5 hrs in mice for a treatment and an equivalent 1 g a day for humans. Development as an obesity and related comorbidities treatment requires a molecular alteration that would reduce the binding to a primary drug extractor such as the liver enzyme CYP 3A4 , the primary enzyme for pharmaceutical extraction in the body. This is difficult because the aromatic and charge transporter properties have to be maintained. Many derivatives of BAM-15 are found in PubChem, but not the molecular modifications from a single atom perspective presented here.