The wild-type S trimer spike of SARS-Cov-2 Omicron without PP stabilizing mutations (model 7tnw), was selected for this work. Comparison of the 7tnw S Omicron with the earliest SARS-COV-2 wild-type all-down 6xr8 resulted in an RMSD of 2.8 Å. Despite such small differences, ADV docking-scores of the initial TTT ligand were 0.20 and 0.67 nM for 6xr8 and 7tnw (Omicron), respectively. These results suggested that the L981F, N969K and Q954H mutations of the Omicron variants that mapped inside the 960-1010 residues innercavity targeted in this work have some influence in the ADV docking-scores and therefore would require additional studies.