Since the 1930s, per-and polyfluoroalkyl substances (PFASs) have been used in several consumer products (including fire-fighting foams) due to their outstanding stability and water/oil repellant properties. However, these compounds pose significant risks to the environment and biosystems. The presence of PFASs in surface water and groundwater can result in exposure to organisms, subsequently leading to accumulation in the body, with adverse effects on the liver, kidneys, blood, and immune system. Because of these deleterious effects, there is a pressing need to identify and understand the bioactivity of PFAS-based compounds that can adversely affect human health.