The first choice as an alternative to the selection of two drugs that share a common target was to use two drug targets present in the same pathway, because under the standard version of mathematical results, we use two drugs that are targeting the same protein. The rationale to extend this to a whole pathway is that pathways are typically used and drawn to describe a particular biological process. Presumably this means that the protein targets found within a pathway are all part of a related biological process. We can then evaluate these combinations as a baseline to see what sort of predictions of synergy we get from its application. From here we can work on approaches that do not include the same pathway and look at targets that are connected at a distance from each other regardless of their pathway association.