The P-score was able to predict correctly the experimental binding poses with good accuracy, independent from the ligands starting point or the binding site conformation. In addition, it was able to predict when none of the correct binding poses were found to be the experimental binding pose. PL-pro was a particularly challenging target, due to the flexibility of the active site and the very flexible P-loop which closes over the ligand. It will be important to test the P-score using other systems to see how general it is.