Here, the dipole-moment change between the ground and the excited state amounts to about 3-4 Debye, depending on the number of water molecules considered. In such cases, the ρ II -dependent differential electrostatic embedding effect can be expected to dominate the changes in the embedding potential, and the state-specific embedding potentials often show better results than state-universal approximations. However, subsequent work on the green fluorescent protein indicated that state-specific embedding potentials alone are not suited to capture all relevant effects. Based on a polarizable classical embedding model, it was shown that a linear-response formulation of the interaction between chromophore and environment can lead to more accurate results.