We obtained the peptide sequences from the GRAMPA repository (Giant Repository of AMP Activities), a robust database created in 2018 that contains the sequences of 6,760 peptides . These sequences are associated with 51,345 experimental minimum inhibitory concentration (MIC) values for 766 different bacteria, the most represented being E. coli (n=9,150), S. aureus (n=8,954), and P. aeruginosa (n=4,966), expressed in µM. MIC is the standard measure of antimicrobial activity and refers to the lowest drug concentration capable of inhibiting bacterial growth. In the present study, we only used the MIC values to filter GRAMPA into subsets. The GRAMPA repository and detailed information are available at: 2.1.2. Cleaning. The creators of GRAMPA obtained the peptide sequences and their experimental values from 5 different databases (APD , DAPD 50 , DBAASP , DRAMP , and YADAMP ) resulting in overlapping information (e.g., same strainassociated sequences, activity measured against multiple strains of the same bacterial species). We exclusively saved the unique pairs of peptide sequence -bacteria -MIC value, and we eliminated sequences with non-canonical amino acids or some unusual modification (i.e., other than amidation).