Among oxidase-based sensors, glucose biosensors based on glucose oxidase are commercially available, but their accuracy is still strongly affected by O2 interferences , making it an ideal target for implementation of the AOx-based O2-scavenger. Glucose has a primary alcohol group in its open-chain form, making it a potential substrate for AOx. In comparison to other primary aliphatic alcohols, and to formaldehyde at the same concentration, the reaction rate of glucose with AOx in presence of O2 is negligible (Figure ). Other classical substrates targeted in oxidase-based biosensing, such as lactate or creatinine as well as sarcosine (an intermediate produced during creatinine sensing), likewise do not lead to any significant oxidation by AOx in presence of O2. Hence, the high substrate specificity of AOx for short chain primary alcohols and formaldehyde as reducing agents ensures that analytes such as glucose, lactate or creatinine are not affected by the AOx-catalyzed O2-removal system.