Here, we develop a novel conceptual framework of defect-engineering for promoting gas enclathration in the water lattice to resolve the kinetics barrier. Defect engineering has been the key approach for creating world-changing materials such as semiconductors, catalysts, and luminescent matter. [need citations] The functionality of these materials is given by the defects in the crystal structures. From this general point of view, we conceptualize the defect engineering for gas enclathration in the solid water lattice. We elaborate foundational insights into the lattice defects of the water structure and uncover the intrinsic link between the engineered defects and the gas enclathration kinetics. We provide an unprecedented evidence-based perspective of a bottom-up approach for controlling gas enclathration in the solid water structure, emphasizing the engineered lattice defects as the path-opening for gas migration in the water lattice, toward sustainable energy storage and CO 2 sequestration.