Fortunately, there is a rising interest in libraries that ease hit development. Cox et al. from the Diamond Light Source developed so-called "poised fragments" consisting of two synthons linked by robust synthetic methodology. This quickly allows scaffold hopping for an identified binder. The concept was further developed by Sreeramulu et al. from the iNEXT initiative. Recently, ChemSpace has launched their "REAL Fragment library", which consists of fragments that can be developed in several directions. Nonetheless, to date, there is no entirely sociable fragment library where a hit can be developed in virtually all directions.