Since the yield of the synthesis and purification process of 1-(2-hydroxyethyl)quininium bromide was relatively low (56%), an attempt was made to select more favorable synthesis conditions. When the reaction environment was changed from DMSO to a solvent with similar physicochemical properties -DMFan increase in total process yield was achieved (up to 73%), most likely due to the precipitation of a larger amount of the main product in the first purification step. At the same time, it should be noted that while the use of DMF provides significantly better process efficiency and translates into a reduction in the amount of waste generated per product mass output, this solvent is considered as potential carcinogen and longterm exposure results in harmful effects to human health . Therefore, further research is warranted to develop more efficient and safer methods for the synthesis and purification of quinine derivatives with a 2-hydroxyethyl substituent. However, the solvents used in the course of purification of 1-(2-hydroxyethyl)quininium bromide belong to the group of media recommended by the CHEM21 solvent selection guide, and moreover, DMSO (unlike DMF) is not considered a hazardous solvent . In addition, the solvents can be easily recovered and reused in the same process. The results of the syntheses and the basic properties of quinine-based quaternary bromides with butyl (1Br), octyl (2Br), dodecyl (3Br), and 2-hydroxyethyl (4Br) are summarized in Table .