The MITE data standard is intended to cover substrate and reaction specificities of tailoring enzymes/maturases that are acting on NP scaffolds. Here, a NP scaffold is defined as the immature NP (e.g. the product of a non-ribosomal peptide synthetase), which is turned into the mature NP by specific tailoring/maturation steps. These tailoring/maturation steps are not restricted to those occurring after chain release (if applicable), but also include those occurring during chain extension while the growing scaffold is still bound to a carrier. However, the enzymatic machinery directly involved in the generation of the NP scaffold molecule (e.g. nonribosomal peptide synthetases, polyketide synthases, ribosomes) is outside of the scope of MITE.