Normally, to establish an effective oxidation of methane with dioxygen to give methanol or methyl ester in high yield under ambient conditions, it is necessary to find out 1) a more effective catalytic species to cleave an inert C-H bond of methane (BDE =439 kJ mol -1 ) , 2) a reasonable way to generate methyl-oxygen intermediates by use of dioxygen or by dioxygen activation, and 3) a chemical environment to guarantee product surviving completely. However, since almost all traditional powerful species including metal complexes, non-metal compounds and enzymes to cleave C-H bonds of methane are carried out in the liquid-phase or on the gas-solid interface, it is often required that good solubility of solvent to methane, high partial pressure of methane, poor coordination of product molecule with reactive species and special operation in the current oxidations of methane. It indicates that methane and its products are in the same phase during the whole process, which makes a dilemma between enhancing methane transformation and reducing side reactions such as an oxidation of methanol rather than methane under the reaction conditions (Scheme 1a). Thus, it should be to design a two-phase process for the conversion of methane, in which methane should undergo an aerobic oxidation in the gas-phase and its target product must be in the liquid-phase without over-oxidation happening (Scheme 1a).