Human toxicokinetic evaluation of TFA showed rapid oral absorption, submission to enterohepatic circulation, and body distribution via blood which included passing through the placenta barrier. The main excretion routes are considered to be via urine and bile. Although TFA is not bioaccumulative according to regulatory criteria referring to aquatic organisms , internal concentrations may increase due to continuous accumulation in exposure media, such as drinking water and plant-based food and beverages. Contrary to the most recent human toxicological review , a similar recent review is not available for (eco)toxicity data. Under CLP, TFA currently falls under the hazard classification "chronic 3" (H412), which indicates long- term harmful effects for water-dwelling organisms . We conducted a search of the USEPA ECOTOX database 107 and ECHA registration dossiers and found that most efforts towards the determination of (eco)toxicity of TFA are from the 1990s. Algae are considered the most sensitive trophic level, with S. capricornutum the most sensitive species and 120 µg/L the lowest determined No-Observed Effect Concentration (NOEC), which was determined for the TFA sodium salt (Solvay data, ECOTOX database extracted for TFA/NaTFA and reported in Berends et al. ). Selected ecotoxicity endpoints (acute and chronic) for other organisms are reported in Table of the Supporting Information, with listed ecotoxicological thresholds and their abbreviations. Overall, most of the testing was performed for acute toxicity, with only a few studies investigating the chronic toxicity of TFA.