The manufacturing process begins by charging N,N-Dimethylacetamide (DMAc) (708 kg, 3.54 X [X is weight to weight ratio (w/w) to the basis charge]) to an inerted reaction vessel. After ensuring that the water content is not more than 0.1%, MR84905F is added (260 kg, 1.30 X, 1.05 equiv.). Agitation is turned on, and the mixture is adjusted to a temperature of 10-20 °C. N,N-Diisopropylethylamine (DIPEA) is then added (170 kg, 0.85 X, 2.00 equiv.), followed by the charge of MR84906 (200 kg, 1.00 X, 1.00 equiv.) while maintaining the temperature range. The mixture is allowed to react for not less than 2 hours and then tested for completion by HPLC. The reaction is judged to be finished when there is not more than 1.0% a/a of MR84906 remaining. After obtaining a passing IPC, methyl tert-butyl ether (MTBE) is charged (1480 kg, 7.40 X) at a temperature between 10-30 °C. The mixture is then heated to 30-40 °C, and water is added (1000 kg, 5.00 X) at a rate which allows the temperature of the mixture to be maintained. The aqueous layer is separated and discarded. The MTBE fraction is then washed with an aqueous mixture of sodium chloride and concentrated under reduced pressure. MR84907 seed is added (0.6 kg, 0.003 X) at a temperature of 30-40 °C, aged, and then n-Heptane antisolvent is added. The suspension is cooled to 15-25 °C and aged further to complete the crystallization. The solids are collected by filtration, rinsed with n-heptane, and dried until the sum of MTBE and n-heptane are not more than 2.0% and water content is not more than 1.0%. 324 kg of off white solid was collected with 95.4 wt% potency and 98.5% area to area (a/a) purity (90% yield).