To achieve more rapid and reliable differentiation of pathogens, a series of simple and reliable sensor arrays based on TPE derivatives (TPE-ARs) are successfully developed by Zhou et al. for high-throughput pathogens screening . As shown in Fig. , all TPE-ARs had a cationic ammonium unit but different calculated oil-water separation coefficient (ClogP, n-octanol/water partition coefficient) (3~7), which correlated with their hydrophobic side chains. The ClogP value could be used to evaluate the electrostatic and hydrophobic interaction between AIE probes and pathogens. Each TPE-AR shows fluorescence response after incubation with different pathogens due to the specific interaction, and vice versa. Then, the fluorescence pattern was analyzed by linear discriminant analysis (LDA), followed by identification results (Fig. ). These sensor arrays can identify diverse pathogens, even normal and drug-resistant bacteria or blends of pathogens, with nearly 100% accuracy. This system verifies that the AIE probes can perfectly meet the actual demand of the high throughput clinical screening and medical observation. Additionally, a more sensitive high-throughput sensor array composed of TPE derivatives with varied numbers of cationic side chains was constructed recently, which could detect and discriminate various bacteria at low concentrations down to 1 × 10 3 CFU mL -1 .