Residue contact networks have been argued to be powerful tools for modeling evolutionary structural changes in proteins . Key Interactions Network (KIN) is an open-source Pythonbased semi-automated tool that identifies of shared residue interaction networks (RINs) within a community of evolutionarily related proteins. KIN is available for download at . Prior work in this space has focused on the evolution of interaction networks between proteins and/or other large networks (e.g. refs. , among many others), or on characterizing functionally/allosterically important interaction networks within individual proteins (i.e. without broader evolutionary mapping, e.g. refs. ), or have been focused on analysis at the sequence rather than structural level (e.g. refs.