The majority of previous works devoted to RI prediction consider polydimethylsiloxane, 5%phenyl-methylpolysiloxane or PEG. For these SP, very large data sets are available. This fact allows for the development of accurate and versatile prediction models and then use the predicted (for these common SP) RI as MD in models developed for other SP. In this work, we investigate whether the predicted RI for PEG is applicable as MD for prediction of RI for IL-based SP.