Chiral Resolution, Characterization and Configurational Stability Studies. (aR)-6 and (aS)-6 were readily separable from one another and racemic iso-6 through the use of a polysaccharide-based chiral column (Diacel IA column) fitted to an automated medium-pressure liquid chromatography unit (Biotage Isolera Prime). Racemization was observable after heating a solution of either enantiopure (aR)-or (aS)-6 at 135 °C in xylenes over a few hours, 16 and the rate of enantiomerization was extrapolated using the Eyring equation (DG ‡ = 31.2 ± 0.3 kcal/mol). 29 (aR)-and