The SP query gave a speed boost of an order of magnitude on the original database enabling synthesis route planning in reasonable time. Additionally beyond Cypher query optimization, with the removal of multiproduct reactions, the FG query is roughly the same speed as SP query. For future work, instead of completely removing multiproduct reactions from the database, another approach would be to classify substances of multiproduct reactions into byproducts and main products, where a byproduct will often be very small and the main product is the expected product. If edges are re-annotated to reflect this, then only paths with expected products would be considered in the search and thus still reduce the total number of paths to transverse and hence reduce the query time (but likely not as fast as removing all multiproduct reactions).