where ∆G CVTS,0 act is the difference between the standard-state Gibbs free energy of the canonical variational transition state (CVTS) and that of reactants. In CVT, transition states are located by a search procedure carried out to find the maximum of the generalized free energy of activation ∆G GT,0 act as a function of the reaction coordinate s. We define s as the arc length along the curved minimum energy path (MEP) through isoinertial coordinates, which are coordinates mass-scaled to have the same mass µ in all directions, as explained elsewhere -see eq. 2.4.8 in Ref. 19, and note that here we take µ = 1 amu. This search process requires the calculation of generalized normal modes along the MEP. At 0 K, we have 96