The nearby amino acids and/or ribonucleotides were identified by homedesigned scripts (*.py) run on PyMol/Python. The list of nearby amino acid or ribonucleotide residues per consensus top-children were then drawn into a homedesigned Origin template using home-designed scripts (*.ogs). The resulting nearby amino acids targeted a newly described sA3G region (~ 160-180 residues), while the rest of positions were similar to those identified in this work when antiVif drugs targeted Vif blue Vif red sA3G + RNA (compare in Figure , sA3G and Grey rectangles above). The ~ 10-100-fold higher affinities predicted by some consensus top-children compared to previous antiVif drugs, could be explained by targeting the newly described sA3G region. 9 and other biochemical properties as critical for A3G binding and degradation (W70, G71, H43 and Y44) and for important A3G interactions (W127, D128, D130, and K270) .