Figure : a) Ligand-receptor COM-COM distance distribution and associated PMF (in the inset) using standard HREM (dashed line) and HREM with adaptive scaling using Eq. 4 (solid line). HREM simulation lasted in both cases 24 ns; b) Ligand-receptor COM-COM distance distribution and associated PMF (in the inset) obtained with a 24 ns standard MD (dashed line) and with 12 replicates of 24 ns MD simulations (solid lines). In green we show the distribution obtained with the adaptive HREM