The term "drug-likeness" denotes an array of chemical properties which impact whether a molecule possesses the characteristics of an oral active drug in humans. It is frequently examined by employing multiple rules, such as Lipinski's Rule of Five, which states that an ideal drug must contain no more than 5 hydrogen bond donors, 10 hydrogen bond acceptors, a molecular weight below 500 Da, and a logP (partition coefficient) under five. These characteristics aid in predicting a compound's bioavailability, solubility, and capacity to permeate biological membranes, all crucial to its potential to be developed into a therapeutic agent.