simplest list of combinations to construct was the list that has the two drugs sharing a common pathway (Figure ). This has to be done using the drugs' targets rather than the drugs themselves, because gene products and proteins are the entities that are most represented in WikiPathways' pathway diagrams. The way the annotations are represented in the WikiPathways RDF allows the use of a SPARQL query to determine if two drugs share a common pathway. The query takes a list of the targets and attempts to match the targets to pathways. A query result is returned when all the conditions of the query are met, mainly that the query finds any two targets that are present in any pathway and filters targets to match those identified targets. This again allows the creation of target combination lists. The targets are then associated with their specific drug. This list of combinations plus the list from the Loewe model our the next list of potentially synergistic drug combinations.