After an iterative process using a forward stepwise linear regression algorithm, potential twoparameter models including steric and electronic molecular descriptors on the cyclohexane substituent were generated. These models were selected based on common statistical metrics such as R 2 , leave-one-out (LOO), and k-fold. Notably, a two-parameter model with good statistical fidelity was identified (Figure ). The model contains an electronic term that describes the Boltzmannweighted partial charge of the atom connected to cyclohexane (ChelpGR Boltz), and the Sterimol parameter that describes the minimum width of the R group at 2 Å along the C1-R axis among all conformers (SterimolC1-R Bmin).