The beta-lactamase hydrolase-like protein phosphatase-like (IPR005939) is situated at the N-terminus of the β-lactamase domain and may possess phosphatase activity, potentially contributing to the development of biofilms or cell adhesion. Calcineurin-like phosphoesterase (IPR024201) is distinguished by the presence of characteristic motifs in multiple enzymatically active phosphatases. The fetal brain expresses one of these motifs, which it isolated from the chromosome 11p13 region. This region is associated with the mental retardation component of WAGR syndrome (Nephroblastoma, Aniridia, Urogenital Anomalies, Mental Retardation). PhoD-like phosphatase metallophosphatase (IPR018946), similar to Ca (2+)-dependent phospholipase D, catalyzes the hydrolysis of the ester bond between phosphatidic acid and phospholipid alcohol moieties. Cell growth and development, cancer occurrence, neurological diseases such as Alzheimer's disease, viral invasion, and other diseases are all closely associated with animal phospholipase D (PLD1/2).