Full method development and analytical procedures have been previously described . Internal standard assignment and instrument and method performance can be found in the supplementary information (table ). Briefly, liquid chromatography-mass spectrometry was achieved using a Waters, Acquity UPLC system coupled to a XEVO triple quadrupole mass spectrometer. A reverse phase BEH C18 column (50 x 2.1 mm x 1.7 μm) was used. Mobile phase A consisted of 95:5 H2O:MeOH with 0.1 % formic acid and mobile phase B was 100 % MeOH. The total method is 19 minutes long, with an injection volume was 20 µL and flow rate was at 0.2 mL min - 1 . Starting conditions were 0 % B (1 min), followed by 8.5 min gradient to 40 % B, 3.5 min gradient to 100 % B, 3 min hold, before dropping back to 0 % B.