The sulfonylation of cyanohydrins 160 was carried out under conditions similar to those applied for aminonitriles 52 and 53 (Scheme 33). In particular, Et3N-catalyzed sulfonylation of the synthesized derivatives 185 was achieved by using of methyl-2-chlorosulfonyl acetate 94, which resulted in the formation of cyanosulfonates 185. The C-H acidity of the methylene unit in compounds 185 was sufficient for the deprotonation by triethamine, leading to the formation of carbanions 186, which subsequently cyclized to form enaminosultones 187 (Figure ). Notably, this method could be applied to monoalkyl-substituted cyanohydrin for the preparation of 187j (45% yield). Scheme 33. One-pot synthesis of sp -enriched sultones 187 modified with hetero(cyclo)alkyl substituents