Compounds 1, 2, and 3 have ligand interactions with 2P4Y whereas 4 and 5 do not. The common interactions between compounds and protein are H-bonding. Compound 2 shows the best binding energy at -8.94 kcal/mol. Compounds 4 and 5 have binding energies of -5.29 and -7.30 respectively. Compound 2 has the most stable ligand-protein complex with relative binding-free energies of -61.08 kcal/mol and -54.68 kcal/mol. These findings suggest the potential of certain cannabinoids to modulate PPAR-γ activity, which is involved in metabolic regulation and inflammation.