First we compare the ranked FSDAM/GAFF2/OPC3_ranked and non-ranked FSDAM/GAFF2/OPC3_JB methods, where the ranked method performed slightly better; these methods used the same simulation approach but differ in that the former used a Gaussian approximation for computing nonequilibrium free energies, whereas the latter used a "boosted Jarzynski" approach for analysis . Both analysis approaches ought to give equivalent binding free energies in certain limits, but their underlying assumptions and the amount of data available result in substantially different performance here. Here, despite its limitations in the SAMPL6 "SAMPLing" challenge , the Gaussian approximation was modestly superior, with 15 of 16 binding free energies predicted within 2 kcal/mol, versus 11 of 16 for FSDAM/GAFF2/OPC3_JB.