Both hydroxyl radicals (OH) and methanol (CH3OH) are widely present in many chemistry related scenes, like atmosphere, 1 combustion, and interstellar space. Methanol, the simplest alcohol, is a green, clean, renewable and pivotal energy source, which is well recognized not only as a fuel to reduce CO2 emissions, but also as a source for a variety of complicated organic molecules, such as olefins, carbonyl compounds, peptides and polypeptides, and even RNA. Similar to the F/Cl/H + CH3OH reactions, the reaction between OH and CH3OH has several product channels. The major channels are the hydrogen abstractions, OH + CH3OH → H2O + CH2OH, (R1)