The canonical representation of Ritonavir is, The molecule, diagram of it, its highest docking pose to Mpro, and its highest scoring pose to CYP 3A4 are shown in Figure . The distributions of docking runs is given in Figure . The distribution is wide and very normal; this is due to the largeness and also the flexibility of 18 rotatable bonds giving it the ability to stick in almost any conformation. The peaks,widths pertaining to Mpro and CYP 3A4 are centered at 57,10 and 102,11.