In this study, we developed the DISSOLVE2-ANIONS set of databases. The database of ∆G * solv (A -) values, D2A-dGsolv-anion, comprises of 6,090 entries focused primarily on the room-temperature solvation free energies of anions across the solvents water, methanol, acetonitrile, DMSO, ethanol, NMP, 1,2-ethanediol, and DMF. To construct this dataset, we curated two other large subsets of thermodynamic data: 5,536 QM calculations of gas-phase acidities (D2A-dGgas) and 8,241 pK a values (D2A-pKa) across those same 8 solvents. These D2A-dGgas is the first corpus of ∆G o acid, gas (AH) values provided digitally at a large scale with no limitations on usage. The pK a dataset introduced herein is among the first to introduce a rigorous cleaning process, which improves the reliability of the data for modeling purposes. We also provided a dataset of solvation free energies of neutral acids from the assess possible sources of error, or swapped out with more accurate methods. Therefore, the composite method may be a suitable method when insufficient data is available to compose data for the direct method.