The APCNs were prepared by UV-induced radical polymerization, as described in the experimental procedure. They were prepared with dimethylacetamide (DMAc) as a solvent for a homogeneous dispersion of the CNCs, whereby the minimum amount of solvent needed to disperse the CNCs was determined experimentally. The CNC-reinforced and peptide-containing block copolymer samples were compared with APCNs synthesized with α,ω-methacryloxypropylterminated poly(dimethylsiloxane) (MA-PDMS-MA) as the hydrophobic crosslinker, without CNCs, but with the same amount of DMAc in the monomer mixture.