The concept of nanotechnology was first theorized approximately sixty years ago by Richard Feynman, who described manipulating individual atoms using large machines to make even smaller particles. Since the 1960s, the field of nanotechnology has expanded many-fold and now encompasses nanobiotechnology, microfludics, microarrays, biosensors, tissue regeneration, nano-medicine, etc. The ability to modify and alter the physiochemical properties of a nanomaterial (e.g. surface area, functionalization, hydrodynamic radius, charge, etc.) to achieve one or more desired outcomes in vivo has been the driving force behind the rapid expansion of the study of nanomedicines. In drug delivery, nanoparticles of all shapes and sizes are being utilized for various applications. However, there are still some limitations of these drug delivery systems (DDS). Ideally, they should be non-toxic, easy to administer to the patient, and carries the drug to the targeted site. From a manufacturing and distribution point-of-view, the ideal DDS is cheap and stable in addition to being effective. In recent years, many of the nanoparticles loaded with anti-cancer drugs have been gaining FDA approval and going onto the market. Pembrolizumab (Keytruda®) from Merck is an extremely successful example; it is a humanized IgG4 isotype monoclonal antibody that targets a specific lymphocyte receptor (PD-1) in charge of programmed cell death. It is recommended by the FDA for the treatment of various cancers, such as melanoma, gastric cancer, non-small cell lung, urothelial carcinoma, and squamous cell carcinoma of the head and neck. Practical nanomedical applications of nanoparticles in drug delivery or imaging are designed to be intravenous injections. This raises the question of how these nanoparticles behave once they enter the bloodstream. Blood is an extremely protein-rich environment, and these proteins can interact with the surface of the nanoparticles, depending on a variety of factors, including the size, shape, and surface functionalization of these nanoparticles.