Telomeric single stranded DNA binding POT1 domain(PF02765) is a telomeric protein that binds single-stranded DNA. This domain adopts an OB fold and bonds single-stranded telomeric DNA. This group includes the proteins POT1 and CDC13, which demonstrate modulation of telomere length, replication, and capping. POT1 is a component of the shelterin complex that safeguards telomeric ends from DNA repair machinery attack.