With respect to the 2-iodo azine component, the scope of the reaction was explored using morpholine (1z) and cyclohexanecarboxaldehyde (2b) as representative coupling partners, under the same optimized reaction conditions (Fig. ). We identified that a range of 2-iodo azines performed well in the carbonyl azinylative amination reaction. Using a selection of di-and tri-substituted 2-iodopyridines, we were able to prepare the corresponding α-alkyl 2-azinyl amines (Fig. , 8a-j), bearing substituents at the 3-, 4-, 5-and 6-position of the pyridine ring. The chemo-and regioselective activation of the 2-iodo group in the presence of other bromide and iodide substituents demonstrates the mild nature of the indium activation process and allowed for the synthesis of substrates such as 8b-e, bearing versatile handles for downstream functionalization. Other functional handles, such as allyloxy (8i), ester (8j) and carbamate (8r) groups could be incorporated into the heterobenzylic amine scaffold. A variety of 2-iodopyrimidines were successfully applied to give amines 5k-5n.