RAD outperforms the null traversal in the recall of virtual actives for all 43 DUDE-Z proteins (Figure ). RAD's average pAUC 10 of 0.72 across all DUDE-Z targets trounces the null traversal's 0.40 average pAUC 10 . While RAD recalls more virtual actives than the null traversal for all targets, RAD performance spans a large range, from 0.53 pAUC 10 for FKB1A to 0.91 pAUC 10 for HDAC8.