Sultams display a diverse range of biological activities, including antibacterial, antibiotic, anticancer, antifungal, antipsychotic, antiviral, biostimulating, cardioprotective, cytotoxic, fungicidal, and mucotoxic activities. Notably, sultam inhibitors targeting the interaction between integrins and endothelial immunoglobulins have therapeutic potential for inflammation and autoimmune diseases, while β-secretase inhibitors show promise in the treatment and prevention of Alzheimer's disease. Moreover, sultam derivatives have demonstrated efficiency in the treatment of lipidemias, associated with abnormal levels and metabolism of lipoproteins in the bloodstream. Other notable examples include the cyclooxygenase-2 inhibitor ampiroxicam 8 (COX-2) 21 , the glaucoma treatment drug brinzolamide 9 22 , and benzodithiazine dioxide 10 exhibiting antiviral and anticancer activities. Figure . Prominent sultam representatives: synthetically valuable camphorsultam (6), saccharin (7), and representative drugs with the sultam moiety 8-10