Sglt. The Sodium-Glucose co-Transporters 1 and 2 are sodiumcoupled transport proteins that facilitate glucose food absorption (Sglt1) and glucose blood reabsorption (Sglt2) .Inhibition of Sglt1 (reference ligand LX2761) blocks intestinal glucose absorption influencing cardiovascular and other diseases. Inhibition of Sglt2 (reference ligand Empaglifozin) prevents kidney reabsorption eliminating excess of blood glucose through the urine, facilitating diabetes control . Sglt are similar proteins displaying 14 transmembrane helices, each having particular molecular properties and physiological targets. The reference ligands are potent binders targeting Sglt 1 and/or 2 with nM affinities. Computational targeting has been recently reported . Exploration for alternative ligands may contribute physiological fine-tuning and/or reduction of offtarget effects. No Sglt have been targeted by DW-BEL.