In the sensitivity calculations for voltage pulses, we observe asymmetry between the charge and discharge directions for almost all degradation mechanisms. For the overpotential dominant electrode, sensitivity of degradation parameters depends on the fitness of the overpotential dominant electrode since W ≈ Ŵd from Eq. 14, where Ŵd is the fitness of the overpotential dominant electrode. The directionality of intercalation at the overpotential dominant electrode during charge or discharge controls the sensitivity of the cell fitness. In the current cell setup, the overpotential dominant graphite anode deintercalates during discharge and intercalates during charge. Specifically as seen in Fig. , the magnitudes of differential conductance and reduction current fraction during deintercalation are both larger than the intercalation values. Since these parameters relate the fitness to the degradation parameters, the fitness is more sensitive during discharge, when the anode is deintercalating, compared to charge, as seen in Fig. for these two degradation mechanisms. In contrast, since the surface blockage mechanism is not potential dependent, no asymmetry appears between the charge and discharge directions for the anode as seen in Fig. . Overall, when degradation parameters are at the overpotential dominant electrode or affect both electrodes, the sensitivity of cell fitness is dominated by the fitness of the overpotential dominant electrode.