A brief introduction was given at the beginning of the module to inform students about the history and evolution of FBDD, its influence on drug discovery, and its progressive departure from conventional drug research. Each group of five students was given the chance to rationally select their target binding site of interest. In this phase, students discussed in groups how they planned to target the Goα protein (i.e., allosterically, orthosterically, etc.). A fragment library appropriate for their suggested targeting technique was then chosen using Enamine. The fragments were then docked onto the chosen binding site on Go utilizing high throughput virtual screening (HTVS) with Maestro Schrödinger (the software licenses for Maestro were generously donated by Schrödinger). The interactive viewing and analysis of computational molecular models were made possible by the software ChimeraX. Students spoke about their protein targeting strategy, library and hit selection criteria, interpretation of the structure-activity connections of hit fragments, and their proposed hit optimization utilizing rational drug design during their final presentation.