Needless to say, all the parameters and key steps of the process can always change, depending on experimental data or computational approaches. For example, Dave and coworkers have illustrated the experimental design (DOE) using a computational tool to prepare norfloxacin-coated LPN (lipid polymer nanoparticle) formulations (for the structure of norfloxacin, see Figure ). There are two reasons for the choice of norfloxacin for this study.