The fact that 71% of the experimental probes have patent matches was a surprise since the impact of potential Intellectual Property (IP) issues on probe usage has not been widely discussed. While this high proportion seems at odds with the Open Science context that probe development teams espouse, the matches only mean the structures are specified in patent documents rather than necessarily being within the scope of allowed claims. Many of the automated extractions may merely represent prior-art mentions including where applicants have exploited analogue expansions from existing probe structures as drug discovery starting points. Notwithstanding, some probe structures may be explicitly claimed in maintained and granted patents (although precisely how many is difficult to assess). However, open patent information has become increasingly available and compound-to-patent document mappings are now indexed for nearly 40 million PubChem CIDs. An interesting example is the Boehringer opnMe GPR142 agonist BI-1046 (MLOGCHDCTRINMU-UHFFFAOYSA-N). Two sources in PubChem have extracted the structure from Boehringer's WO2020007729 "Triazole benzamide derivatives as GPR142 agonists". From CID 146293963 (via SureChEMBL SID 405725530), we can map the structure to example 2 and a table of low nM IC50 SAR values for 20 analogues (with synthesis details) that can also be found in the PubChem "Similar Compounds" section.