Atomate2 enables chaining an initial fast hybrid relaxation using CP2K with a slower second relaxation using VASP with denser k -point sampling for improved accuracy. Together this simulation procedure can significantly accelerate the computation of complex structures and is a key feature of the heterogeneous defect calculation workflow in atomate2. Achieving interoperability between multiple DFT packages and MLIPs is facilitated by the standardization of workflow inputs and outputs through use of a common application programming interface (API).