The Wet Milling Method is widely employed approach for producing Curcumin nanoparticles. This approach is designed to enhance the solubility, stability and bioavailability of Curcumin. In this technique the primary instrument used is Wet Milling equipment. In this technique the Curcumin is dispersed with two stabilizers namely Pluronic F127 and Sodium dodecyl sulfate (SDS). This suspension is subjected to ultrasonication agitation to ensure the thorough mixing and particle size reduction. Wet Milling equipment uses mechanical force to reduce the particle size of Curcumin (6.71±0.9 nm) bringing them to nanometre range.