Overall, using the multi-parameter process, i.e., MEW, to process IND-loaded scaffolds for sublingual drug delivery applications enables the fabrication of adaptable patient-specific drug-loading. This could potentially be done by adjusting for example the nozzle size, the resulting fiber diameter and the number of stacked layers leading to different weights of incorporated and delivered drug, as previously discussed. Although these first MEW printed drug loaded scaffolds using an ABA triblock copolymer for sublingual drug application seem to be promising, this method has some limitations. The combination of two high temperature methods (HME and MEW printing) limit the choice of drug, as it needs to be sufficiently temperature stable. Also, the total amount of drug that can be printed in suitably sized scaffolds is somewhat limited (here about 60 mg), which makes the use of a highly potent drug necessary. Additionally, the Tg of the used polymer needs to be relatively low to allow printing below the degradation temperature of the drug, in the case presented here, the Tg of the polymer is 27 °C. However, to prevent recrystallization of the drug, a generic rule is that the Tg of the polymer should be around 50°C above the storage temperature. Nevertheless, as the long-term stability was not tested within this study, the influence of the low Tg on the recrystallization behaviour of the drug, as well as the dissolution behaviour of the scaffold after storage is not clear. It should be noted, depending on the viscosity of the polymer melt at a certain temperature, it would be also possible to use polymers with a higher Tg for MEW printing. The critical values that need to be tested in advance are the degradation temperature of the drug and the viscosity of the polymer melt at a certain