To obtain TR-CP, we chose PEDOT:PSS as the conductive component because it is waterdispersible, oxygen stable, displays high conductivity in the solid state, and is readily used and studied in bioelectronics. For the thermo-responsive component, PNIPAM was chosen because of its lower critical solution temperature (LCST) close to body temperature (32-35 °C). To promote the phase separation of hydrophobic and hydrophilic domains and facilitate PNIPAM inter-chain interactions above the LCST to form gels, we synthesized (Schemes S1-S2) and characterized (Fig. ) block copolymers of PSS with PNIPAM with varying molecular weights and block ratio (Table ) by reversible addition-fragmentation chain transfer (RAFT) polymerization (SI, Section 3.1). These block copolymers were then used as templates to synthesize PEDOT:PSS-b-PNIPAM (SI Scheme S3, Fig. ) by oxidative polymerization of EDOT in water.