Except for Alphafold PDB coordinate files, each PDB chain primed for processing in this work is initially examined for potential conformational states that may reveal transitory or occluded binding pockets on protein structure. These conformational states alongside the experimental state and Alphafold predicted structures are scanned for identification of druggable binding sites. Methodologies describing protein conformer generation and pocket prediction are detailed in CONCOORD and DeepPocket , respectively. Briefly, each PDB chain and/or conformer structure was initially run on Fpocket this study.