Peptides have vital roles in many biological processes, including cellular communication, control of enzymes, and modification of immune responses ( ). Also, targets for drug development are peptide-protein complexes since small peptides either act as inhibitors or modulators of protein activity. Furthermore, peptides derived from proteins can be the basis for developing peptide-based treatments such as peptide mimics or vaccinations ( ). Therefore, it is essential to understand the binding topologies and strengths of peptide-protein complexes.