Ducati et al. explored the use of a chimeric collision cell integrated into a quadrupole time-of-flight platform . Their study focused on evaluating two dissociation techniques, collision-induced dissociation (CID) and electron-induced dissociation (EAD), for the LC-MS analysis of low molecular weight compounds. Compared to CID, EID fragmentation of the species (10 to 20 eV) from standard compounds resulted in additional fragments, primarily due to neutral losses and, in some cases due to ring openings. In addition, the EAD fragmentation of [M+Na] + or [M+K] + precursor ions showed radical cation and electron impact type fragments, providing the opportunity to use EI libraries to support analyte identification.