Considering the central role of SARS-CoV-2 (M pro ), along with the powerful antiviral activities of the MNPs under investigation and as a part of our continuous program to identify pharmacologically active MNPs with adequate antiviral potentiality against SARS-CoV-2 (COVID-19 pandemic) , herein we comprehensively exploring virtually the SARs of a focused library of fifteen marine batzelladine alkaloids against the dimeric form of SARS-CoV-2 (M pro ) using an integrated package of advanced computational tools including (MDock), (MD) simulations and (SARs).