We selected a list of hydrophobic drugs for formulation development and compatibility estimation. The main criteria for the selection of drugs was their hydrophobicity and associated concerns, which can limit therapeutic outcomes. The physicochemical properties of the selected drugs are shown in table . At first, SPs of the drugs were calculated by HnV and YMB method. To proceed, initially, the molar volume of the drugs were calculated by Fedor's method and by HSPiP software.