All studies with harvested tissue used 7-10 week-old male C57BL6/J mice, and were regulated by the Animals (Scientific Procedures) Act 1986 of the U.K (Personal Project Licenses P2ABC3A83 and PP1778740). Approval was granted by the University of Birmingham's Animal Welfare and Ethical Review Body. All in vivo imaging experiments were performed with approval and oversight from the Indiana University Institutional Animal Care and Use Committee (IACUC).