The coarse suspension was repeatedly wet-milled using a high-pressure homogenizer (Microfluidizer ® M110-EH, Powrex Corporation, Hyogo, Japan) at 27,000 psi to reach the target z-average. Then, 10 mL of the wet-milled suspension For the sample analysis of the rat PK study with samples from 2712-4632 hr, after protein precipitation with acetonitrile, the samples were injected into a YMC-Triart C18 metal-free column (3 µm, 2.1 inner diameter × 50 mm, YMC Co., Ltd.) and eluted from the column under the gradient conditions in Table with a mobile phase consisting of 0.1% formic acid in water and a mobile phase consisting of acetonitrile.