The initial dataset -comprising HPLC experiments collected over an extended periodconsisted of approximately 25 thousand experiments . The majority of the data fell into the following three categories: 1) Semi-Preperative size exclusion chromatography experiments separating small molecules away from target oligonucucleotides 2) Prepratative reverse phase ion pair chromatography experiments separating a desired oligunucleotide from a mixture of small molecules and undesired oligunocleotides 3) Reverse phase chromatography experiments aiming small molecule analysis mainly for the purpose of qualifying and ensuring the health of the HPLC instruments. Among these, 93 experiments were annotated by a human expert as being affected by air bubble contamination. Subsequent analysis showed no correlation between the type of chromatography and the likelihood of of air bubbles detected by deployed ML model.