The area of computer science that focuses on constructing and operating DNA -based computers represents a field of study that investigates the utilization of DNA as both hardware and software for advanced, tailored, and precise diagnostics in biomedicine. One of the key elements of this approach is using machine learning techniques to retrieve specific DNA sequences, which are then used to design smart diagnostic biochip projects. In one of the recently introduced technologies, the biomolecular queue automata strategy allows for the arrangement of molecular dimensions of computational operations by employing sequential actions of cleavage and ligation of DNA molecules. The incorporation of enzymes is of significant importance in the design of biomolecular computers with memory, enabling their functionality. The authors also introduced the Queue-PCR method, which employs biomolecular computers, and automates the PCR process. During the design phase of these biochips, machine learning techniques play a vital role, highlighting the potential application of enzymes in constructing diverse data formats akin to those in computer science .