Fig. shows the electrostatic effect on the binding of DS -to the ACWI, including the total change in the solute-solvent energy and entropy, ∆ el E vw⊕el,W ⊕C (z) and -T ∆ el S vw⊕el,W ⊕C (z) (solid lines), as well as the electrostatic components of the energy and entropy, ∆ el E el,W ⊕C (z) = ⟨V el,W ⊕C ⟩ 1 and -T ∆ el S el,W ⊕C (z) = ∆ el F el⊕vw,W ⊕C (z) -⟨V el,W ⊕C ⟩ 1 as dashed lines.