Quantic is a fragment spectrum level quantification tool with several different applications. First, Quantic can be used to quantify the fragment ion intensities of identified PSMs in a given pepXML file. Second, Quantic has an ANNOTATE mode to provide a single string annotation of matched fragments and their intensities. Third, Quantic can be used to quantify data from cleavable tag linkers that can be measured in DDA or DIA modes. For DIA data or data collected with wider isolation windows, Quantic has DIAMODE options that implements an isotopic correction allowing it to recover underlying quantities of measured peptides. A summary of the capabilities of TPP quantitation tools is shown in Figure .