TRPV1 agonists have been shown to reduce inflammation. For example, the injection of capsaicin reduced mortality in rats with induced abdominal sepsis . In addition, the injection of capsaicin in mice with lipopolysaccharide stimulation (LPS)-induced bone inflammation inhibited prostaglandin E2 production by osteoblasts. Prostaglandin E2 induces inflammation and bone resorption, so inhibiting prostaglandin E2 production also inhibits inflammation and bone resorption associated with the inflammation .