For the neutral species (NaCl, glycine, benzene, and phenol), absolute differences between HetPCM and Voronoi-PEqS solvation energies are 1 kcal/mol even for the case where ε nonp = 1 and ε solv = 78.4. These solvation energies are much smaller as compared to the ions, a Calculations at the HF/def2-TZVPD level. b Permittivity construction; see Fig. . c Voronoi construction of ε(r) using L = 0.5 Å, k = 10, and a 0.05 Å grid spacing.