The similarity between nanobubbles and microemulsions; ii) The shrinking of large bubbles and the adsorption of amphiphilic molecules lead to the formation of the compressed amphiphilic monolayer at the nanobubble interface; iii) The thermodynamic stability of bulk nanobubbles can be reached once the compressed amphiphilic monolayer is formed; iv) Nanobubble size can be determined from the rigidity of the compressed amphiphile monolayers; v) Trace organic contaminants could be a source of amphiphilic molecules for the formation of compressed amphiphile monolayer.