We build reaction networks for eight possible templates (Figure , Round 1) with a variety of functionality. In particular, we include several different kinds of nucleophiles; ethene (representing a double bond), hydroxide (nucleophile and strong base), ammonia (nucleophile and weak base) and phosphine. We also include entries that act as acids; the hydronium ion (strong acid, conjugate base weak nucleophile), hydrogen sulfide (weak acid, conjugate base strong nucleophile) and formic acid (representing a carboxylic acid). Formaldehyde is included as an example of an electrophile.