The simulated free-energy barrier changes from 18.2 kcal/mol under field-free condition to 15.8 kcal/mol under a 0.1 V/Å field, leading to a drop of 2.4 kcal/mol (Figure ), close to the value (2.2 kcal/mol) predicted using an implicit solvent model. This corresponds to roughly 50 times increase in the rate constant using Eyring-Polanyi equation. Committor analysis confirms that the asynchronicity of the TS with explicit solvent molecules also increases under the EEF (Figure ), where ΔCV increases from 0.75 Å in the zero-field condition to 0.89 Å under Fz = 0.1 V/Å.