Focusing instead on the macrocyclic catalysts that do not exhibit notably low release energetics and comprise neutral and anionic analogs of axial ligands, we observe that the presence of anionic axial ligands slightly improves release energetics by reducing the overall charge on the catalyst, and thus the electrostatic attraction to bound isopropanol, as seen in prior work (Supporting Information Figure ). Given the prior focus on linear free energy relationships (LFERs) between DE(oxo) and DE(HAT), we explored whether Fe and Ru catalysts had distinct tradeoffs evident in metal-specific LFERs (Figure and Supporting Information Figures and). Averaged over all spin states, we find that Ru catalysts show a clearer correlation between DE(oxo) and DE(HAT) reaction energies (Pearson's R = -0.86) with a relatively steep slope (-0.52) while Fe catalysts show a weaker correlation (Pearson's R = -0.34) with a more gradual slope (-0.24, Figure and Supporting Information Figure and Table ). Thus, Ru catalysts adhere more closely to the metal-oxo formation vs. HAT LFER observed in single-site heterogeneous catalysts, albeit with a steeper trade-off (literature slopes around -0.45 to -0.43) than those observed in prior work (Supporting Information Table ). Fe catalysts, on the other hand, exhibit larger deviations from this scaling relation, an observation that is consistent with trends observed in homogeneous catalysis where metal-oxo vs. HAT LFERs are more readily disrupted. This presents a greater opportunity in optimizing Fe catalysts for C-H activation.