The essential molecules of life are mostly found in one specific chirality. While proteins are made mostly of L-amino acids, nucleic acids often contain D-ribose sugars. Many of the hypothesis that address this predominance stems from the theories of the origin of life. One such hypothesis states that in the RNA world, preceding the modern "protein world," chiral amino acids worked as chaperons for RNA folding and functions. It is also assumed that in the evolution of amino acid and protein-based biological machinery that succeeded RNA world, the interaction of amino acids and RNA motifs could also play a role in the above chiral predominance. RNA tetraloop hairpins are a special type of tree-dimensional motifs where the majority of bases in an RNA structure belong to the paired regions (Watson -Crick base pairing between purine and pyrimidine bases in a given sequence) forming the stem part of RNA while the unpaired region having a specific sequence forms the loop part of the RNA. The stability, similarity, structural features and probable interactions between different hairpin structures are studied and compared using various experimental techniques such as NMR and various other absorption spectroscopic studies. The significant feature of these types of motifs involves spontaneous transitions between native folded states to form various misfolded and elongated single-stranded structures. The role and dynamics of these structural motifs in various recognition processes are extensively evaluated by various experimental methods for understanding various transition states and RNA folding pathways. The recent FRET experimental studies on GAAA tetraloop structures show that the kinetics and thermodynamics of events associated with folding-unfolding equilibria is highly influenced by various complexities of amino acids. The arguments based on theories related to chiral amino acid-based origin of life are validated to an extent by various studies that specify that the energetics and kinetics are altered in the presence of amino acids from the secondary to tertiary level of interactions in RNA motifs .