On the other hand, natural product libraries always act as an excellent pool to find therapeutic agents against a new biological target . The availability of diverse natural compound databases and recent advances in computational chemistry have made the screening of potential inhibitors easier, but surely attention should be given towards the structure-based means and sample number to remove the promiscuities. Nevertheless, natural compounds from traditional Indian medicinal trees such as Vasaka tree (Justicia adhatoda) and Neem tree (Azadirachta indica) have been scientifically proven to have bronchodilatory and respiratory stimulants . Importantly, one major alkaloid found in Vasaka leaves is Vasicine that is linked with inhibition of proteases enzyme isolated from Pseudomonas aeruginosa . Therefore, natural compounds from these sources have been targeted for early-phase screening against SARS_CoV_2 proteins. For example, computational screening of natural compounds from Neem tree against SARS_CoV_2 M and E proteins have been reported in the search to find potential hits . Additionally, phytochemicals from traditional Indian medicinal plants such as Justicia adhatoda, Ocimum sanctum and Swertia chirata have been computationally screened against two SARS_CoV_2 proteins, namely the protease enzyme (M Pro ) and RNA-dependent RNA polymerase (RdRp) . In this study, an alkaloid named anisotine was reported as a dual inhibitor of both proteins, whereas a polyphenol named Amarogentin was reported as best inhibitor of RdRp. However, crucial structure-based information was not provided in this report in support of promiscuous inhibition profiles exhibited by structurally different inhibitor molecules against two totally different protein targets. Additionally, an in silico attempt has been reported to find inhibitors of main protease (M Pro ) by taking only six alkaloids from Vasaka tree .