We have introduced a reaction fingerprint encoding scheme, DRFP, based on a simple 4-step process comprised of extracting circular n-grams, XORing, hashing, and folding. DRFP is capable of reaching state-of-the-art performance without extending the use of machine learning models from classification or regression tasks to the fingerprint creation task. The fingerprint creation algorithm is available as a pypi package (drfp). Source code and documentation are available on GitHub ().