Stronger fluid face-face (or weaker side-side) interactions promote side-on orientation at both interfaces. Enhancing the hydrogen-bonding capabilities of a small molecule in the sideside direction has recently been shown to promote a more face-on orientation at a solid substrate, consistent with the predictions of our model. However, other methods to tune the interaction anisotropy, such as introducing longer/bulkier side-chains that may block the face of the molecule or deplanarising the backbone, also change the shape anisotropy, which may have the opposite effect on interface orientation.