We now use the EC for understanding and predicting solvent-mediated reactivity of acid-catalyzed reactions based on the topology of water and cosolvent mixtures. Previous work has demonstrated that varying the cosolvent type and concentration in a cosolvent/water mixture impacts the relative reactivity of acid-catalyzed reactions for biomass conversion. Walker and co-workers analyzed the influence of solvation towards reactivity by studying the structure of water in molecular simulations of a single reactant molecule in different cosolvent/water mixtures (snapshot shown in Figure ).