Residence time (𝜏 𝑅 ) for an analyte binding to a specific target is defined as the time it remains in a specific contact position with its target. Mathematically, it is inverse of the dissociation rate (koff) of the analyte-target complex. koff is the inverse of the average of time the analyte molecules are bound to the target in different binding events (toff). So, in turn, residence time becomes equivalent to toff.