The driving force of such workflow is MINT's ability to consolidate every manipulation made by the user into a numeric 'score' which represents the chemical validity of these actions. A detailed description of this score is given in the section entitled Scoring of Player's ligand conformations. In Figure , PDB 4XUF, a protein-ligand complex, has a score of 331 in its initial state (Figure ). The user then performs a bond rotation on the ligand structure through the VR controllers and interface (Figure ). This action results in the score increasing to 333 in real-time, and indication that the user has improved the potential effectiveness of the ligand towards the target protein.