Although the 3D differences among CSP models were mostly due to their NANP disordered repeats, there were also some smaller variations between the two N-and C-terminal α-helices (Supplementary Materials / 5CSPalphafoldmodels.pse, NANPmodelmimics.mp4, NANPmodelrolling.mp4). Therefore, to explore the possible model-dependence of the dockings targeting 24C, several full-length-alphafold models, were ADV blind-docked to 24L-derived CSP top-children conformers selected among those predicting < 20 nM affinities (Figure , red). The results showed ~ 10-50-fold ranked affinity variations among different CSP models (Figure ). The CSP0 initial model predicted the highest affinities, most probably because it was employed to DWBEL-generate the 24Lderived top-children employed for the comparisons.