The computationally predicted structures of the 54 experimentally realised organic cages that formed one singular topology 'cleanly' (where all three experimental methods of automated characterisation resulted in a 'pass') are shown in Figure , with those which formed alongside insoluble precipitate shown in Figure , and those which cleanly formed mixtures of topologies shown in Figure . Currently, to the best of our knowledge, this study represents the highest number of cleanly formed cages from a single screen, a considerable number when the total number of POCs discovered to date is only in the hundreds. Of these 54 cages, only the most common Tri 2 Di 3 and Tri 4 Di 6 topologies were observed. However, as discussed above, opportunities and applications can still arise for cages with smaller cavities that may not possess intrinsic porosity, but may pack in the solid-state to create extrinsic pore channels, and find applications in sensing in solution. Precursor combinations that have equilibrated to a single molecular species without insoluble precipitate, and that form a shape-persistent cage, would be the most desirable from a materials discovery perspective, and in relation to POCs, would require a pore size over 2.89 Å, the kinetic radius of a hydrogen molecule, in order to more likely find application in gas uptake and separations. POCs with larger cavities are particularly challenging to synthesise due to the increased likelihood of collapsing on desolvation. In addition, the precursors that lead to shape-persistent organic cages with a cavity large enough for guest molecules, i.e., POCs, are often larger, resulting in greater degrees of freedom and competing synthesis pathways for the formation of alternate products, alongside easier collapse mechanisms. However, using the hybrid workflow and automated data analysis, we identified ten POCs that would be considered porous, based on having a pore size over 2.89 Å -these are shown as the last ten molecules in Figure . The largest of these cages are B6 and D6, with cavities of 9.75 and 9.96 Å respectively -however, while these, alongside the fourth largest pore-containing cage S24, have been reported previously, several new organic cages with large pore sizes were discovered including J17 (7.94 Å) and the Tri 2 Di 3 cages M28 (7.40 Å) and B15 (7.51 Å).