Hence, there is a need for a data standard that allows to capture the substrate and reaction specificities of NP-acting tailoring enzymes/maturases independent of the EC number system, and directly connected to the overarching NP biosynthetic pathway. To bridge this gap, we propose the Minimum Information about a Tailoring Enzyme/Maturase (MITE) data standard (Figure ). MITE is conceptualized to complement the MIBiG data standard with regard to reaction and substrate specificity of NP acting tailoring enzymes. Not intended to replace other databases, MITE would provide a framework to describe enzymes that are challenging to classify using existing methods. To prevent redundancy in data storage, MITE would provide cross-links to other resources where possible. The purpose of the MITE data standard is to create a machine-readable and versatile repository of NP-associated enzymatic reactions, to be utilized for in silico biosynthesis, annotation purposes, prediction tools, phylogenetic analyses, and metabolic engineering.