Taken together, the NMR experimental evidence suggests that AS4 features a IMHB network of weak to moderate strength. These findings suggest furthermore that the FerroTACs can adopt more compact conformations in nonpolar solvents potentially acting as molecular chameleon. The conformational changes may occur through independent rotational adjustments of the ferrocene substituents around the central ferrocene core, as indicated by the shielding of amide signals in apolar solvents. Such conformational changes could lead to a reduced polar surface area and a smaller radius of gyration in the cis conformation, which would align with an enhanced permeability.