Although assessment of static wetting properties offers useful information, we questioned whether the results could be transferred to more intricate flow-based systems. Paper-based devices are generally designed around specific flow configurations, such as lateral flow (with the front moving in-plane along the paper sheet), vertical flow (with the flow perpendicular to the stacked layers), or a combination thereof (three-dimensional paper microfluidic networks). This is an important consideration for the electrofluidic layers fabricated here, as the directional nature of the lasing process yields LIG-E of anisotropic structure, which may interact differently with varying flow directions. To explore this, we flowed water through LIG-E embedded in cellulose and compared the fluid front positions as a function of time for neat paper, LIG-E, and oxygen plasma-treated LIG-E in different flow formats (Fig. ).