All systems are first subjected to energy minimization using the steepest descent method, followed by a 10 ns equilibration in the N pT ensemble. During equilibration, the geometries of the DCPAMs are restrained, and the water molecules and ions are allowed to move freely. Temperature and pressure are controlled at T = 298 K and p = 1 bar using the velocity-rescale thermostat and the cell-rescale barostat , with coupling constants τ = 0.1 ps and τ = 2 ps, respectively. Production simulations are then performed for 130 ns in the N pT ensemble but different Parrinello-Rahman barostat . Trajectories are recorded every 4 ps, with the last 100 ns extracted for data analysis (25000 trajectories). The configurations are visualized using the VMD and OVITO packages.