In the present study, we compared the performance of compound identification using three similarity measures: Cosine Correlation, Shannon Entropy Correlation, and Tsallis Entropy Correlation, with consideration of the weight factor transformation. Our focus was specifically on single similarity measures rather than composite ones. The Cosine Correlation was selected due to its established efficacy and widespread use as the best single similarity measure. The Shannon Entropy Correlation was included based on recent findings by Li et al. The comparative analysis employed electron ionization (EI) and electrospray ionization (ESI) mass spectral libraries for GC-MS-based and LC-MS-based metabolomics, respectively.