The COVID-19 pandemic has had a profound impact on the world, affecting nearly every aspect of our daily lives. Since its emergence in late 2019, the virus has spread rapidly across the globe, infecting millions and leading to significant morbidity and mortality. In addition to its toll on human health, the pandemic has also had extensive social and economic consequences, disrupting businesses, straining healthcare systems, and triggering widespread unemployment. The pandemic has underscored the importance of effective disease control measures, including testing, contact tracing, and vaccination campaigns. While significant progress has been made in developing and deploying vaccines, the emergence of new variants has highlighted the need for continued vigilance and adaptation in our response efforts. Ultimately, the COVID-19 pandemic has emphasized the interconnectedness of our global community and the critical importance of collaboration, scientific innovation, and public health preparedness in addressing global health crises. The envelope protein is one of the four structural proteins encoded by the RNA genome of the novel coronavirus, SARS-CoV-2, responsible for the COVID-19 pandemic. This protein plays a crucial role in the viral life cycle, especially in the assembly and release of new virions from infected cells. As a transmembrane protein anchored in the lipid bilayer of the viral envelope, it is abundant on the virus surface, marking it as a significant target for developing antiviral therapies and vaccines.