The PP-LFERs can conveniently predict a variety of partition coefficients for a given compound. While solute descriptors are available for several thousand compounds, they are rarely available for PFAS. In the past, Goss et al. determined solute descriptors for four fluorotelomer alcohols (FTOHs) and four fluorotelomer olefins (FTOs). Later, Endo and Goss 9 recalibrated the solute descriptors for FTOHs, which were evaluated again by Abraham and Acree. In addition, descriptors for very short PFAS (C≤3, mostly refrigerants) have been reported, and the ABSOLV database on the website 10 lists descriptor values for several per-and polyfluorinated alkanes and alcohols of unknown origin. Solute descriptors are unavailable for other PFAS, including those that have been frequently detected in the environment such as other fluorotelomer compounds and perfluoroalkanesulfonamides (PFASAs) with different substitution patterns. In a previous study, our group measured the values of KHxd/air, hence L in eq 1, for 64 neutral PFAS to elucidate their nonpolar interaction properties. The study showed that L can be explained by summing the contributions from the fluorinated and nonfluorinated parts of the molecule. For the polar interaction properties, however, such a simple additive principle may not work because the polar functional group can be significantly influenced by the strongly electron-withdrawing perfluoroalkyl group. In fact, previous studies have shown that A values for 4:2, 6:2, and 8:2 FTOHs are higher than those of nonfluorinated alkyl alcohols and that B has the opposite relationship. Such effects should have a major impact on the partition properties of fluorinated organic compounds in general.