The adenosine A 2A receptor belongs to the G-protein coupled receptors family and is a therapeutically relevant target in the field of immuno-oncology and Parkinson's disease. We analyze a series of triazines reported by Congreve et al. (see Supporting Information for ligand structures) where residence times were characterized by SPR and later reported by Bortolato et al. Interestingly this experiment was carried out with a mutation-stabilized version of the protein. We performed these simulations in the membrane (POPC) phase as reported before although the experimental setup prompted us to compare an alternative preparation that yielded similar accuracy (see Supporting Information).