Under the EU's CLP, TFA is classified as harmful to aquatic life with long-lasting effects (H412) . Under REACH, the toxicological threshold for the general population (Derived No Effect Level, DNEL) is derived only for the oral route and set to 0.042 mg/kgbw/day, while for other routes of exposure, no hazard has been assumed and concluded. The threshold for the oral route was derived based on the observed effects from a 90-day rat-feeding study .