In the first part of this section, we investigate the pseudo-translational and pseudo-rotational contributions in the normal modes calculated using the QM/MM approach for the seven solute-solvent systems: furan in benzene, naphthalene in acetonitrile, pyridine in methanol, 1,3-butadiene in water, uracil in methanol, propanamide in water, and formaldehyde in water, including also the expanded QM subsystem for formaldehyde in water. We also inves-tigate how the removal of the pseudo-translation and pseudo-rotation through projection, as