The The statistics of structural comparison with PDB templates is given in Table , it is seen that the proteins from the SARS-CoV-2 are significantly close to the proteins of SARS CoV and the amino acid alignment in the biding region is the same in both the viruses. The alignment of the 305 residues from 3268-3573 aa of the Novel Coronavirus COVI-19 with the template 2a5i is shown in Fig. and the alignment of the 315 residues from 1568-1882 aa of the Novel Coronavirus COVI-19 with the template 3e9s is shown in Fig. . and it was found that there was a complete match in these genomes of the virus. The fact that the region is conserved in all these SARS-CoV-2 sequences further emphasizes this ligand interaction of Aza-Peptide epoxide with the protein can be used as an antiviral in SARS-CoV-2. Similarly A PSI-BLAST of a length of 315 amino acid residues 3268 -3573 in Frame 2 with 315 amino acid residues 1568-1882 in Frame 2 from SARS-CoV-2 virus isolate Wuhan-Hu-1 (Genbank Accession Number MN908947.3) was conducted to ascertain the conservation of these amino acids in 250 genome sequences of SARS-CoV-2 and it was found that there was a complete match in these genomes of the virus. The fact that the region is conserved in all these SARS-CoV-2 sequences further emphasizes this ligand interaction of ligand GRL0617 with the protein can be used as an antiviral in SARS-CoV-2.