The Voronoi-based analysis of the area per lipid (Figure of SI) and membrane thickness (Figure ) for different types of lipids, depending on saturation level and presence of CP rings show that for the MMS and MMU systems sharp changes in thickness at the phase transition temperatures (310 K for MMS and 270K for MMU) are observed. There are clear differences between the saturated, mono-, di, and tri-unsaturated lipids near the phase transition point for the above modified membranes. The saturated lipids show the sharpest change at the phase transition point followed by monounsaturated and di-unsaturated lipids. On the other hand, absolutely no changes are observed between cyclopropane ring-containing, mono-, and di-unsaturated lipids and the values practically merges with each other in the NM system. Therefore, the LCFAs homogenize the membrane composition.