As mentioned above, one goal in the creation of the SAVI versions so far has been to build novel molecules, not just modify existing molecules with new or interchanged functional groups. We aimed for this by emphasizing coupling and ring-building transforms. Sixteen of the 53 transforms are exclusively ring-forming (see Tables and, third column), which yielded 8,227,198 products with newly formed rings. We note that intra-molecular application of coupling transforms can also lead to the formation of rings. However, this may also lead to polymer formation and was therefore generally excluded in this version of SAVI. Extra information may be added in the future into the transforms themselves to better handle intra-molecular cyclization.