inhibitors against these fibrils against the disease . It has been discovered recently that desmethyl pinoresinol, which is contained in the fruits of Vernicia fordii, binds to monomeric αsynuclein, inhibiting it and preventing the fibril from further elongating . Some of the common properties required for a good inhibitor are they should not only inhibit the fibril formation but she also help in reducing the level of toxicity caused by the alpha-synuclein species.(13) Furthermore, they should have a high blood brain barrier permeability. The accuracy of the molecular docking simulations depends on the scoring functions used to predict the binding affinity. In addition, in molecular docking the role of water molecule in ligand binding is not considered. Finally, in most of the molecular docking simulations the proteins are treated as a rigid structure; hence, the dynamics and conformational changes that can take place in ligand binding is not computed. Some of the ways to overcome these limitations are as follows.