Regeneration of the catalyst during an EC' reaction produces CVs with enhanced catalytic currents, with the magnitude and profile of the resulting current-potential curve reflecting the rate of the catalytic reaction. However, directly determining the reaction rate constant from the catalytic current requires that the reaction is under kinetic control and with negligible consumption of the substrate (i.e., pseudo first-order conditions). CVs under kinetic control can be visually identified by their distinctive sigmoidal currentpotential profiles. Experimentally, obtaining the desired CV profile requires exploring a parameter space of various catalyst concentrations, substrate concentrations, and scan rates. Manual optimization of experimental parameters can be simplified through use of the kinetic zone diagram for the EC' mechanism, shown in Figure . with corresponding CV profiles for the different kinetic regimes. Ccat is the bulk catalyst concentration, Csub is the bulk substrate concentration, kc is the catalytic rate constant, and ν is the scan rate. Expressions for dimensionless parameters λ and γ are built using these variables. The KS zone is highlighted, showing the typical sigmoidal CV from which direct quantification of kinetic parameters using Equation 5 can be achieved. where F is Faraday's constant, R is the ideal gas constant, T is temperature, Ccat is the bulk catalyst concentration, Csub is the bulk substrate concentration, kc is the catalytic rate constant, and ν is the scan rate. The KS zone complies with requirements of kinetic control and negligible substrate consumption. The catalytic current, ipl, is taken at the plateau region of the current-potential curve and can be used to determine the catalytic rate constant using equation 3: