In our previous report, we were limited to conducting two mechanophotocatalysis reactions per ball mill. In an effort to accelerate reaction screening and simplify the vessel design, we have developed new reaction vessels and holders designed to increase the throughput of mechanophotocatalysis reactions, Fig- We used transparent polypropylene Eppendorf vials as chemically resistant, cheap, single-use reaction vessels. As an initial proof-of-concept, and in line with our previous report, we encapsulated the Eppendorfs inside PMMA jars to allow for safe, secure clamping in the mill, which we refer to as the 'V1 holder'. This vessel design was used for much of the optimisation of the reactions presented in this study.