We used JAEGER to design novel antimalarials by first building a JT-VAE model with data from a Novartis-internal malaria proliferation assay. JAEGER yielded quickly realistic novel compound ideas that were well aligned, in terms of their molecular properties as well as synthetic accessibility, with the chemistry explored in the assay. The compounds proposed by JAEGER were also dissimilar to those found in the training set as well as those in the Novartis compound archive. In this sense, JAEGER's sampling technique strikes a balance between existing chemical matter and novel compound ideas. The new compounds 1 and 2 were synthetically accessible in 6 synthetic steps from readily available starting material and displayed reasonable physiochemical properties sufficient to warrant further investigation.