understand the seed-mediated growth of gold nanorods (AuNRs) in particular. Their work revealed insightful correlations between 8 synthesis factors such as the silver amount and seed aging time, and 5 different AuNR outcome responses including shape yield and AuNR size. By fractional factorial design of experiments, Burrows et al. effectively explored many synthesis factors within a fixed protocol, conducting a total of 42 experiments. Despite the study's scope, which primarily involved two levels (e.g. NaBH 4 amounts of either 0.0378 g or 0.0450 g) for each synthesis factor, their approach enabled efficient sampling of the synthesis space. Furthermore, Burrows et al. highlighted a notable challenge concerning the limited reproducibility in human-controlled nanoparticle syntheses. Specifically, despite employing the same recipe and the same chemical stock, noticeable variations in synthesis outcomes were observed among different experimenters within a single research group. Recently, Park et al. conducted an in-depth investigation into the correlations between similar synthesis factors for multiple growth stages. Notably, they expanded upon Burrows et al. by exploring a broader range of levels for each factor.