mutagenicity (lesions at the level of genetic material), teratogenicity (damage that a chemical compound causes to an embryo or fetus), effects on reproduction (damage to the female or male MW: molecular weight, LogP: water-octanol partition coefficient, TPSA: topological polar surface area, HBA: hydrogen bond acceptors, HBD: hydrogen bond donors, nrotb: number of rot atable angles, M: mutagenicity, T: tumorigenicity, I: irritability, ER: effects on reproduction, X: no toxicity, X: toxicity. Similarly, Table presents the results of acute oral toxicity with the value of lethal dose 50; for the case of the reference drug nifurtimox it is 2.50 mol/kg and for the 31 molecules under studies it ranges between 2.30 and 3.10 mol/kg. According to the values obtained, the compounds are classified in group 3 of the Organization for Economic Cooperation and Development as moderately hazardous chemicals, which indicates that they are compounds suitable for experimental therapeutic use that must be corroborated in an animal model, suggesting OECD guidelines 423 or 425 to corroborate this prediction ). Finally, in the ADMET in silico process it was determined whether the compounds can be hepatotoxic and / or nephrotoxic. Of this set of molecules, 16 could produce liver damage while 10 compounds could cause liver and kidney damage; for this reason, these 26 molecules were discarded at this stage of the process shown in Figure .