The SUN is also a multi-targeted TKI used for treatment of cancers like renal cell carcinoma . The Ra calculation showed the following compatibility estimation with the increasing order, i.e. pBuOx > pPrOzi > pPentOx > pBuOzi (Figure ). Like ERL, the formulation results showed that none of the triblock copolymer were capable to significantly solubilize SUN (Figure ). Maximum apparent solubility was observed for A-pBuOx-A triblock copolymer (≈0.6 g/L at 6 g/L SUN feed) (LC ≈ 5.5 wt.% and LE ≈ 10%). The aqueous solubility of SUN was determined in-house to be 0.023 g/L (Table ). Streets et al. reported methoxy-PEG-PCL nanoparticles, which were capable to solubilize 0.32 g/L of SUN . The A-pPrOzi-A triblock was found to be a non-solubilizer for SUN. Overall, the Ra, successfully identified the (comparatively) better solubilizer, but the rest of the trend was not consistent with the compatibility estimation.