Finding a global model for the kinetic-thermodynamic relationship generalisable for any chemical reaction must arise from the most fundamental characteristics. Any inductive approach from linearity or parametrisations specific to one reaction class, even when not ad hoc, hamper both the physicality and generality of the resulting equations. For these reasons, we investigated what mathematical features should be present in the global energy responses, followed by a deductive approach in agreement with the former and stemming from an interpretation of microscopic reversibility.