To illustrate the possible interfacial bond interactions, we proposed the THF-and DMSO-water configurations in Figure . The sp 3 -orbital hybridized carbon has two or three positively-charged hydrogen atoms, and each oxygen has two electron lone pairs marked as ":". Therefore, we also denote the O-H⋅⋅⋅O as O-H:O in the following discussions. With a relative polarity of 0.207, the THF (C4H8O) has eight protons and two pairs of electron lone pairs, compared with the DMSO(C2H6SO) of 0.444 polarity having six protons and two electron lone pairs. The distribution of the lone pairs and protons makes the solute dipoles exert an anisotropic electric field to polarize the surrounding water molecules. The H proton and electron lone pair interact with their alike or unlike of the nearby