Regardless, by virtue of their remarkable stability, CO poisoning resistance and HOR activity, the combination of PtGe bimetallic clusters and 2D supports seems a very promising approach for the design of novel resilient and active HOR electrocatalysts. The simultaneous tailoring of cluster composition and support is demonstrated to be an effective strategy to successfully adjust the catalytic properties. In the future, we intend to investigate the coverage effects under different applied potentials for the ORR reaction in both acidic and alkaline mediums.