Our comparative analysis between ACP-S and ACP-NS subsets pointed to subtle differences in AAC and PCPs, resulting from different distributions between polar, charged and hydrophobic residues. From a design strategy standpoint, we could convert a non-selective ACP-NS peptide to its ACP-S counterpart with a few site-directed mutations. Therefore, we evaluated the similarity between the two subsets regarding sequence motifs (domains) and sequence homology.