There is a great drive to go sub-nano in precious metal catalysis, because in sub-nano clusters, nearly all the expensive metal atoms are exposed to reactants, increasing costeffectiveness. Clusters can also have better catalytic activity than the bulk metal 1 , provide a parameter for catalyst tuning (size), and can break scaling relations that can limit the activity of larger catalytic centers 2 . Pt-based catalysts are widely used in refining, transforming chemicals, and converting environmentally harmful products , and the challenge to the use of sub-nano Pt catalysts in such applications relates to stability: deactivation via thermal sintering, and by poisoning. For example, in alkane dehydrogenation for alkene production, sintering may be rapid at operating temperatures, as can poisoning by carbonaceous side products ("coking").