Drug delivery and gene therapy may help with cancer treatment. Diseases treatment using gene-based therapies has gained significant attention over the past decades . The fundamental idea of gene therapy is to alter or modify defective/missing gene sequences to cure inherited diseases, including cancer . Gene delivery is considered an alternative method to traditional chemotherapy used in treating cancer. However, the transfection of the cell by oligonucleotides (ONs) is tedious due to cell degradation, and low efficiency of cell internalization. Therefore, there is an obvious demand for efficient nucleic acid delivery systems that would ideally promote intracellular delivery. Viral and non-viral vectors were reported as a carrier to improve the cell transfection of oligonucleotides. Among several types of non-viral vectors, cell-penetrating peptides (CPPs), short peptides with sequences less than 30 amino acids, are promising . CPPs show high biocompatibility and offer the potential for large-scale production. However, CPPs exhibit low transfection efficiency . Hybrid conjugation of CPPs with inorganic nanomaterials improved their efficiency and may open new venues for multifunctional treatment .