We also show that ABFE calculations outcompete cheaper endpoint methods such as Nwat-MM/GBSA and, for one system of our benchmark, offer comparable results to relative binding free energy methods. Although ABFEs do have a several times larger computational cost to such methods, advances in GPU utilisation have been making the high throughput use of such a technique more tractable. That being said the Nwat-MM/GBSA method employed here showed reasonably good predictive ability, particularly in supporting retrospective elaboration decisions, and could easily be used as a low computational cost prefilter to more expensive ABFE calculations.