Fourteen antihistaminic drugs were ADV blind-docked to H1R (8x5x.pdb ) to select for parents / cavities for DWBEL co-evolutions (Supplementary Material / antihistaminics.dwar). Four antihistaminic-drugs were selected with the highest ADV affinities (ebastine and fexofenadine) or published H1R-complexes (mizolastine and the cardiotoxic astemizole) . Histamine was also included to comparatively explore the possibilities of the physiological histamine co-evolution and H1R-histamine binding-cavity.