Here, we report how competing and coexisting QI effects drastically impact rates of triplet pair formation in bridged homodimers (SFC-𝛽-SFC). We posit that graphical models of QI can be used to understand topological effects of bridging units in symmetric chromophores. To test this hypothesis, we use three alternant hydrocarbon bridges (phenylene, naphthalene, and anthracene) for which graphical models of QI patterns are well characterized. Figure shows the predicted CQI (14Ph, 26N, 15N, and 26A) and DQI (13Ph, 16N, 27N, and 27A) structures for each bridge that links two pentacene or tetracene chromophores (P𝜷P and T𝜷T, respectively). We find that quantum interference effects can be predicted by graphical models in all compounds, with triplet pair formation being slower for any 𝛽 that exhibits DQI. However, as we move from the smaller phenylene bridge to the larger naphthalene and anthracene bridges, we find that it is also important to consider other factors (including molecular geometry and resonance between SFC and bridge FMOs) to obtain a holistic picture of the SF rate constant. Importantly, we identify a distinct correlation between the strength of the charge transfer (CT) absorption resonances in the linear absorption spectra and the relative rates of iSF. These studies reveal the critical nature of chromophore connectivity in controlling the formation of the triplet pair, and the necessity of combined experimental and theoretical approaches to understand chemical design principles.