One main factor limiting TP suspect screening is the lack of available information in open databases that is standardized and thus suitable to be extracted consistently and reproducibly to form meaningful suspect lists. Of the 816 parent compounds on the CNS list, only 44 had associated TP information (i.e., one or more TPs) that could be extracted from PubChem as performed in this study. Certainly, there are far more pharmaceutical background who tirelessly collect samples and have contributed to this work through healthy discussions in the office, as well as all those contributing to the many open science efforts mentioned. ELS gratefully acknowledges the contributions of several of the PubChem team to the TP and PubChemLite efforts, including Evan Bolton, Jeff Zhang and Paul Thiessen (all NIH/NLM/NCBI).