Because SERS is a near-field phenomenon, the Raman We also explored how BA structures influence the detection of the glycosidic linkages. We examined eight BA receptors containing various functional groups and aryl structures. The appropriate BA receptors, including 3MBA, 4ABA, and BBA, could exhibit an excellent performance of differentiating between α2,3 and α2,6 linkages of sialic acids. This discovery suggested that the careful selection of BA receptors is crucial to improving the detection accuracy.