The pore size, shape, and internal surface chemistry of MOFs can be readily tuned to maximize their selectivity for a noble gas. MOFs are comprised of an extended network of metal ions or clusters (nodes) coordinated by organic ligands (linkers) [ ]. A vast number of MOF structures are achievable via de novo synthesis, by combining different inorganic nodes and organic linkers within many different topologies, and via post-synthetic modification [ ].