To derive the final list of top-leads, some particular methods were used for this work. For instance, seeSAR leads from our previous work were selected to start our previously described sequential rather than previous independent consensus strategy, similar to the one applied in our most recent work . Comparisons using ranks rather than absolute docking-scores, were used as recommended by many other authors for higher prediction accuracies ; . Finally, lead tendencies to apparent and most probably erroneous high affinities such as those only due to unspecific increase in molecular weights and hydrophobicities , were corrected with a unique LELP parameter for ligand efficiency normalization, selected among other methods .