We analyzed how the size of the system, target error threshold, and direct space cutoff impact the performance and accuracy of GLST. Our systems included neutral salt water boxes of varying sizes containing Na + and Cl -ions at varying concentrations. Details of each system are outlined in Tab. I. We refer to the runtime of the algorithm as the amount of time taken to compute the energy and forces of a system one time and do not include the time taken during initialization and memory allocation. The runtime was taken as the average over 50 energy and force calculations. To evaluate the accuracy of our method, we compared the energies and forces to a direct pair-wise interaction using the Coulomb potential.