Even though Eq. 2 is valid for a broad temperature range, the available machine learning models for the solvation free energies and aqueous solid solubility are restricted to 298K. To calculate the solid solubility at temperature T , the enthalpy required to dissolve a solute from the solid phase into the organic solvent at the specified temperature (i.e. the dissolution enthalpy, ∆H diss,T ) is required. Those are related through the modified Van 't Hoff equation (Eq. 4), with R the ideal gas constant. Integration of Eq. 4 between 298K and the required temperature T yields Eq. 5.