While fullerene mainly will act as acceptor sites when physisorbed on phosphorene. Also, fullerenes increase the metallic character of phosphorene. The latter suggest fullerenes could act as signal amplifiers for specific redox applications considering that phosphorene-based materials have shown interesting electrochemical performance as electrode materials. Deposited mesoporous and organic molecules have caused effective signal amplification on phosphorene-based sensors to determine prostate-specific antigen, hemoglobin, clenbuterol, and polychlorinated biphenyls, reaching an excellent specificity, chemical stability, low detection limits, and reproducibility . The electrochemical amplification mechanism emerges from the good charge transfer in the hybrid material, an enhanced electrical conductivity of the electrode, and the excellent electrocatalytic activity of the deposited molecules upon adsorption . Therefore, our results open avenues for the study of Phos-Fullerene hybrids in electrochemical biosensing.