Through the modification at position 2 with a methylene guanidino triazole moiety, this mannose derived Man84 showed an IC50 for the receptor in the micromolar scale, gaining a 100-fold affinity compared to natural mannose (IC50 ~ 2 mM 30 ). This potential was further exploited with the dimerization of the compound on a rod-like scaffold, whose multivalency enabled to reach a nanomolar scale-affinity, most likely through chelating phenomenon. Divalency also increased the L-SIGN vs. DC-SIGN selectivity ratio, reaching a 1200-fold value toward L-SIGN with the most efficient ligand PM74.