Differential pulse voltammetry (DPV) was used for nimesulide determination, operating under the given conditions: modulation amplitude -50 mV, modulation time -7 ms, interval time -1.85 s, and step potential -0.01 V. The Nimesulide was detected in a potential range of 0.6 V to 1.0 V in 0.01 M PBS (pH = 7.0101) and in treated industrial sewage (pH = 6.92) . The nimesulide limit of detection (LOD) was estimated using eq. ( ).