2) Minimal energy path calculations (MEP) can also be performed by combining the rapid GFN2-xTB method 27 from the xTB package and the nudged elastic band (NEB) algorithms implemented in ORCA. This is useful to obtain transition states with multiple reaction coordinates, for example. This approach takes as input one structure on either side of the transition state and constructs a path between them. The use of GFN2-xTB significantly reduces the computational cost of this method and makes it viable for relatively large systems.