Therefore, instead of considering simulations of an insulin-𝛼-chymotrypsin complex and an insulin dimer, we worked to develop metrics for proteolytic stability and dimerization propensity based on standard MD simulations of monomers and their glycosylated analogs. The hypothesis is that the insulin monomer that participates in either a complex with 𝛼-chymotrypsin or an insulin dimer should encode at least some important structural insights into both the proteolytic stability and the dimerization propensity. As long as we are able to explore the configurational space of monomer-based structures sufficiently, the conformational ensembles we get from the simulations should shed light on developing reasonable metrics for the two insulin properties.