Most rodenticide anticoagulants are made of antagonists inhibiting the vitamin K epoxide reductase complex 1 (VKORC1). VKORC1 enzymes are implicated in the carboxylation of proteins (II, VII, IX, X) required for blood coagulation. VKORC1s are found in most biological species as integral membrane enzymes that maintain the balance between reduced-active Vitamin K and its oxidized-inactivate forms generated after carboxylation.