Over the years, the ability to selectively break a C-H bond to create new connections has attracted increasing interest. While past methods allowed C-H transformations for simple molecules, recent synthetic protocols 2 enable selective C-H activation and diversification in larger molecules. This has, for example, attracted the pharmaceutical industry to implement such C-H transformations to diversify different types of molecules ranging from small drug-like molecules to intermediates and lead compounds. Especially late-stage functionalization is a promising emerging field that allows chemists to efficiently explore the chemical space in complex molecules by exchanging a C-H bond with different functional groups to modify the biological activity in drugs. However, pinpointing which C-H bond is reacting requires can be challenging.