Another simplifying assumption of the theory used to derive the scaling of c † with N is that the process of single-chain folding does not affect the multi-chain aggregation rate. As chains fold, they gradually become more compact, reducing the diffusion-limited collision rate between chains. Thus, there is a complex interdependence between the single-chain folding and multi-chain aggregation that cannot be fully captured by the simple theory used here. This means that the estimated critical concentrations are a lower bound: accounting for chain collapse during aggregation will increase the concentration at which aggregation dominates single-chain collapse. Nevertheless, especially for the shorter chains, for which the size difference between a fully extended and collapsed chain is less significant, the calculated concentrations should be a reasonable approximation to the actual concentrations at which folding occurs as fast as interchain aggregation.