Following the approach developed in our model reactions, we implemented the reaction as shown in Scheme 2. Varying conditions (see SI, Table ), we find similar responses to temperature: at room temperature no enantioselectivity is observed in the system. Lowering temperature to favour TIPS-β-CD acting as an SPG for (S)-1 (preventing access to catalyst and reagents), we are able to produce (R)cinacalcet (4c) in good yield and high enantiopurity (up to 94% ee with 80% aldehyde conversion) from the racemic amine.