The in vivo photothermal imaging was then conducted after the mice accepted PBS, P-TN, P-TN-Dox, and P-TN-Dox@CM nanogels through intravenous injection in the tail vein. As displayed in Figure and 5f, the local temperature in the tumor of mice received PBS increased only to 35.8 o C under 808 nm laser irradiation for 15 min (0.8 mW cm -2 ). In marked contrast, the local high temperature of ~48 o C was reported in the tumors of mice that were dosed with P-TN and P-TN-Dox nanogels. Furthermore, by virtue of homologous targeting effects, the mice injected with P-TN-Dox@CM nanogels presented the fastest temperature rise, and the final temperature of 52.8 o C was recorded after NIR irradiation for 15 min, which was sufficient to ablate the tumors in vivo. All these results signify that the homotypic membrane camouflage strategy renders the nanogels with superior tumor specific targeting ability, and the P-TN-Dox@CM nanogels not only own outstanding heat-generation capability but also are able to act as wonderful contrast agents for in vivo fluorescence imaging and photothermal imaging. Therefore, therapeutics accumulation and therapy process can be monitored in real-time, which is particularly conducive to imaging-guided precise diagnosis and therapy.