Musculoskeletal disorders often involve disruptions in both biochemical and biomechanical processes. The interface between biochemical pathology and tissue biomechanics is evident in therapeutic interventions. For example, the administration of bisphosphonates in osteoporosis not only inhibits osteoclast-mediated bone resorption but also influences the biomechanics of the bone, increasing its density and reducing fracture risk . Treatment approaches, like pharmacotherapy or physical therapy, aim to target these disruptions. For example, antiinflammatory medications reduce inflammation by inhibiting the production and transport of inflammatory mediators, while exercise programs can improve joint stability and reduce pain through mechanical adaptations . Biochemical pathways involved in disease mechanisms often have biomechanical repercussions. For example, the pro-inflammatory cytokines in rheumatoid arthritis induce enzymatic degradation of collagen and weaken the biomechanical properties of the joint tissues . Effective treatment strategies for musculoskeletal disorders often necessitate an understanding of the coupling between biochemical processes and mechanical stimuli. Therapeutic interventions for osteoarthritis, such as viscosupplementation, are designed to improve the viscoelastic properties of synovial fluid, thereby enhancing nutrient transport and mechanotransduction pathways . This emphasizes the importance of addressing both chemical and biomechanical aspects of treatment to restore normal function and alleviate symptoms.