There are four compounds in the current project, which have been tested >100 times for their activities to SMYD3. One of them is S21 (Figure ) which has been computationally investigated here. The other three are for more potent compounds that are from a related but slightly different series. The relatively large number of tests makes it possible to verify the distributions of the experimental data. It should be noted that while compounds a and b do not show any drift in the assay over time, compounds c and d (Table and Figure ) show a small amount of time dependency.