The hydrodynamic radius of the coiled PEG chain, 𝑹 𝐏𝐄𝐆 , scales in the Flory theory for good solvents as 𝑹 𝐏𝐄𝐆 ∝ 𝑛 ".@ . Experimental observations found 𝒌 𝐩 (𝑛) ∝ 𝑛 ".J@ , for 𝑛 > 30 for PEGs, which is subsequently used as constant parameter for the MW-dependent rate constants in the diffusion-limited regime. The resulting reaction rate constants for the polymer, 𝑘 D , and monomeric units, kM, versus n are plotted in section S1 of the Supplementary Information (SI)).