Alongside spectroscopic methods and binding affinities, one can also use biochemical exchange techniques such as Hydrogen-deuterium exchange. These methods provide a readout about whether a region was solvent exposed or not, Chapter but modern methods capture fast timescale events. These methods can then be paired with independent MD simulations to identify structural motifs that are undergoing dynamics . Similar type of labeling methods, such as the use of thiol labels and Ellman's reagent, enable one to identify cryptic pocket (druggable surface of proteins that are transiently exposed) .