Molecules can be sorted into sets of interest by considering the combinations of their difference and similarity flags. One molecule in this pipeline will yield five minimized structures. Taking pairwise combinations of these structures can yield ten molecule pairs, and thus up to ten flags. Molecules that yielded a large number of difference flags, regardless of the force fields of origin, are of particular interest for force field parameterization. Specifically, we set aside molecules with five or more difference flags for further analysis, we call this our FivePlus set.