The CV of SANs-coated SPE in PBS solution showed a reduction peak and significant reduction current at -0.1 V. This indicates that the catalytic effect of Fe-N-C SANs lowered the reduction peak of hydrogen peroxide reaction by 0.54 V, which significantly improves the sensitivity and selectivity of the sensor for H2O2 detection. Figure shows the CV curves of Fe-N-C SANscoated SPE in PBS solution with 7.5, 5, and 2.5 mM H2O2. The CV curves showed an increasing reductive current (from -36.90 μA to -85.32 μA) as the increase of H2O2 concentration from 2.5 to 7.5 mM. The above result shows the excellent electrocatalytic ability of Fe-N-C SANs for H2O2 decomposition and demonstrates the relationship between response current and analyte concentration.