While the exact mechanism for such spontaneous fusion is unknown, the relationship between particle size and propensity to fuse with a bilayer may be explained via computational modelling, similar to that presented by W. T. Góźdź. They discuss that while the phase assigned to particles of both size populations may be identical, smaller particles may exist as several possible topological varients. Bilayer deformation at the facets of each particle class is necessary for bending energy minimisation, though has been proposed as having a greater influence on smaller particles over larger ones. Therefore, a greater degree of curvature frustration may be present in particles at 130 nm, leading to a higher frequency of spontaneous fusogenic events.