Therapeutic targeting of telomerase activity is another prospective anti-aging approach. Since age-associated telomere shortening is known to play a key role in senescence, proper maintenance of telomeres is decisive for genome stability. Telomerase is the reverse transcriptase enzyme, which is able to sustain telomere length via telomeric repeat addition onto the chromosomes ends. Telomerase activation has been proposed to be an anti-aging moderator, which can play a role in the aging-associated diseases therapy.