Executing an aerosol-phase synthesis procedure based on this abstract description requires a suitable aerosol source and reactor geometry. Our investigations have targeted vibrating mesh atomizers (VMAs), a chemically resistant and cost-effective aerosol source that is amenable to automation and for which we have created a highly adaptable programmable hardware platform. A suitable reactor configuration requires in turn ensuring (i) there is an aerosol source for each release timeline and, (ii) that the sources involved in each mixing event are arranged in a convergent geometry to facilitate droplet coalescence, Figure . In cases involving the combination of reagents and intermediates, such as the second step of synthesizing Sudan I, the reagent source is aimed at a region with a large concentration of intermediate microdroplets. For initial validation of our system's ability to generate reactivity within microdroplets, we undertook benchmark reactions exploring fundamental reactivity archetypes. We chose reactants that would undergo a visible color change upon reacting in order to facilitate observation of reactivity outcomes within individual droplets.