To understand how coacervates and other phase separated compartments could have formed and evolved on primitive Earth, one must take into consideration the environmental parameters and how such parameters could have influenced the chemicals on primitive Earth to initiate reactions that would have lead to primitive phase separation (and those that reacted within those compartments).There are many different factors relevant in early Earth environments that could affect the formation of coacervates, such as variations in temperature, pH, solvent, or salinity, just to name a few. At the molecular level, for example, peptides can become insoluble or inactive when the pH, temperature, solvent environment, or salinity changes, sometimes leading to the formation of an amorphous solid precipitate that becomes unable to interact with counterions to form coacervates. Similarly, RNA or other nucleic acids are also very sensitive to environmental conditions, often denaturing or degrading at high temperatures, divalent cation concentrations, or pH. At the compartment level, temperature could affect coacervation, as certain systems show coacervation ability only above a specific temperature, while others only coacervate below a specific temperature. For example, in systems composed of lysine-rich elastin-like polypeptide (ELP) and hyaluronic acid, coacervation occurs only when the temperature rises above 25-30 degrees C, i.e., the lower critical solution temperature (LCST). However, when protamine, an arginine-rich polypeptide, is mixed with either citrate or triphosphate, coacervation can only occur below 40-60 degrees C, i.e., the upper critical solution temperature (UCST). Additionally, coacervates are stable at a specific pH range, as changes in pH affects the charges of the polymers comprising the coacervates, resulting in inhibition of the electrostatic forces needed to maintain phase separation. In one case, when a coacervate itself is dissolved in water, only the shorter peptides selectively self-coacervate into stable liquid droplets when either the temperature or the pH rises above the optimum value, leading to changes in the droplet structure. While this environmentally induced structural change could result in emergent structures or function, it may also go the opposite way and result in inactivation of any coacervate functions.