In an earlier study, we developed a "Bridge DoE" for liquid formulations, which looked at selecting a ternary combination of surfactants from a set of five, i.e., 10 possible combinations . This prior work demonstrated balanced exploration and exploitation of the design space, however, relied on an expensive objective function (Eqn. 1) which scales particularly poorly to an over 50-fold higher dimensionality design space in this study. ∅(𝑫) = ω log+𝐸 -[U(𝑫)]1 + (1 -ω)log (d(𝑫))