Biofilm-related infections, such as dental plaque and bone implant, have brought great suffering to patients and heavy financial burden to society . Bacterial biofilm is a unified community where bacteria are encapsulated by the matrix, leading to the resistance to antibiotics [100]. PTT has been widely studied as one of the most attractive strategies for combating bacteria with its advantages on light-controllability and hardly no drug resistance . Recently, He et al. report a highly efficient photothermal nanoparticle (TN NP to eradicate biofilms (Fig. ) . TN NPs were prepared by encapsulation of NIR-absorbing photothermal AIEgens (2TPE-2NDTA-02) with DSPE-PEG2000 (Fig. ). By taking advantage of active intramolecular motions in the aggregate state and enhanced molar absorptivity, TN NPs showed high ability in photothermal conversion and excellent photobleaching resistance. Under 808 nm NIR laser irradiation, the temperatures of the aqueous solutions elevated with time and saturated within 3 minutes (Fig. ). The prepared NPs can effectively eliminate mature S. aureus biofilms upon NIR laser by destruction of the adjacent bacteria and deactivation of the adhesive components (Fig. ). Therefore, PTT is one of the most promising potential candidates for the clinical treatment of biofilm in the future. anti-bacterial functions by utilizing AIEgen based nanofibrous membrane (TTVB@NM) (Fig. ) . Under simulated sunlight irradiation, TTVB@NM exhibited efficient ROS generation and moderate photothermal conversion performance (Fig. ). Furthermore, TTVB@NM was covered on a medical mask and displayed efficient antimicrobial activity against pathogenic aerosols (Fig. ). It is notable that the filtration efficiency and air permeability of the TTVB@NM coated mask showed comparable even better performance than that of other reported antimicrobial wearable materials. AIEgens (IQ-TPE-2O, IQ-Cm, and IQ-TPA) for selectively photodynamic killing of fungi and effective treatment of keratitis (Fig. ) . Driven by the intrinsic discrepancy in surface membrane potential between fungi and mammalian cells and negative mitochondrial membrane potential (MMP), these cationic AIEgens designed with proper hydrophobicity were expected to preferentially accumulate in the mitochondria of fungi over mammalian cells and cause mitochondrial disruption by PDT effect (Fig. ). The results indicate that all three AIEgens, especially IQ-TPA, exhibit excellent antifungal activity for in vivo treatment, which is much better than the clinically used photosensitizer rose bengal (Fig. ).