A popular in silico method of finding potentially druggable sites is through MSMD simulations, whereby a protein is solvated in water with a high concentration of organic probe molecules. Regions where probes are observed to spend a large amount of simulation time are deemed potentially druggable. These simulations generally work well for protein binding sites that are solvent exposed or are located on the surface of proteins, but for binding sites occluded from the solvent or more deeply buried, the simulation times required to overcome conformational energy barriers exceed what can be conveniently simulated. Using GCNCMC, the limitations associated with diffusion times can be negated by performing insertion and deletion moves into or from the immediate vicinity of the protein. Setting the GCMC region to cover the whole, or parts, of the protein means that sampling can be focused only on these areas. This protocol is essentially a traditional MSMD simulation with enhanced sampling by GCNCMC. Here, we have applied this approach to find the occluded binding pockets of T4L99A and MUP1. To do this, we set our GCMC region to cover the whole protein by anchoring it to a central protein residue.