We generated three sets of dose-response curves: eight-point curves with four replicates for all 68 Enamine compounds, 16-point curves with eight replicates for 10 compounds, and another set of 16-point curves with six replicates for 10 compounds. The eight-point doseresponse curves started with an initial concentration of 66 µm and progressively divided the promote diversity in the top predicted compounds. We compared the prediction overlap between the ensembles and the best base models in the model selection stage (Table ).