This study presents an autonomous approach to MicroED using commonly used and freely available software. The data collection process requires no human intervention after initial setup, making it suitable to run during less busy microscope shifts. This approach is built on the widely distributed CryoEM data collection software, SerialEM, which is already installed at many CryoEM labs. The hope is that by using commonly available software, this will inspire more laboratories to implement a higher level of automation in their MicroED data collection processes.