for other electrophilic series . The stronger protein destabilization response to alachlor treatment could also reflect the differential metabolism of the compounds. Compared to alachlor, acetochlor metabolizes faster into 2-chloro-N-(2,6-diethylphenyl)acetamide (CMEPA) and 2-methyl-6-ethylaniline (MEA) . While microsomal pathways are not available in the HEK293T cells, other chloroacetanilide decomposition pathways could be available.