Simulations of complex and relatively large systems, which are often necessary for modeling SOM, often require considerable computing resources. One approach that can be used to speed up molecular simulations is the so-called coarse-graining technique , whereby several atoms or even entire molecules are grouped into new particles, often known as beads. This reduces the number of particles and interactions that need to be evaluated, which improves performance. The coarse-graining technique inherently involves a trade-off, as it results in a loss of atomistic detail. However, this limitation is not a significant drawback when applied to SOM molecules, as their precise structural details are largely unknown. Different coarse-grained force fields exist , including the widely used Martini force field .