where the subscripts cp and wp refer to cosolvent-protein (the IL) and water-protein 61-64 . If is positive (the KB integral of the IL is greater than that of water), the IL Γ 𝑐𝑝 preferentially solvates the protein. When evaluated for water, this metric is known as the preferential hydration parameter ( ) For solutes of non-zero net charge, Γ 𝑤𝑝 Equation 2 must be adjusted to account for ionic imbalance , but here Ubiquitin is neutral. Finally, distance-dependent coordination numbers were computed with the bulk_coordination function of the MolSimToolkit.jl package v1.22.3, which uses CellListMap.jl for the fast computation of interatomic distances.