As a practical application, we examined the effects of receptor conformational ensembles and compound pose reranking in identifying active compounds of Abl kinase (Abelson tyrosine kinase). Abl is of clinical significance due to its causal role in chronic myelogenous leukemia (CML); in about 90% of cases of CML, a chromosomal translocation forms a "Philadelphia chromosome", which creates a fusion between the Abl and break-point cluster (Bcr) genes to produce a protein with constitutive kinase activity . Inhibitors of Abl kinase activity are in clinical use as treatments for CML and other cancers since the US approval of the targeted inhibitor imatinib in 2001 and have significantly improved clinical outcomes .