We have also used the SG rules derived from the threecomponent materials to address five-component materials, which were tested experimentally (Fig. and). For this purpose, V Ç was fixed as tellurium based on the best fourcomponent catalysts and molybdenum, niobium, tantalum, and antimony were evaluated as V ^. Thus, ruthenium, tungsten, phosphorus, tellurium, and V ^ enter in the composition of the considered five-component materials. The agreement between the SG rule and the measured oxygenate yield is reasonable in spite of the much higher materials complexity with respect to the catalysts used for training. In particular, the five-component catalyst corresponding to the highest yield of oxygenates (59.60 % at 400ºC) contains tantalum as V ^ element and the composition-averaged electronegativity for this material is 3.947 eV. Such VY value lies within the threshold defined by the SG rule. These results demonstrate the potential of the SGD-HTE-&theory approach to identify generalizable rules describing exceptional performance. Indeed, the identified four-and five-component catalysts are significantly more complex than those of the training data set (three-component materials). Moreover, the four-and five-component outstanding catalysts achieve oxygenate yields (60.19 and 59.60%, respectively) up to twice as large as those obtained with three-component materials (highest value of 26.85 %). Thus, the SG rules hinted at materials that are significantly more performant that any of the observations used in training.