Using default parameters, two clusters were identified in the initial chemical point cloud of 1000 compounds and was downsampled with a target membership of 10%, or 100 molecules, of the initial set and yielded a downsampled set of 99 molecules. The overall topology of the initial chemical point cloud (Figure ) is preserved post downsampling (Figure ) when using the default Dedenser parameters. The original distributions of the ZINC compounds was largely retained when downsampled (Figure ), demonstrating Dedenser's ability to preserve chemical diversity when reducing chemical point cloud membership.