Overall, all prompts generated reasonable sets of children molecules compared to the parent molecule depending on the prompt instructions. Prompts A through D yielded child molecules with slight variations compared to the parent while retaining the overall shape of the parent framework and installing slight variations in functional groups. Prompts E through H, which were instructions for producing children molecules that were different from the parent, yielded child molecules that were a departure from the parent regarding functional groups and framework connectivity without unreasonable departures in terms of In the case of both parents, all 10 generated children are valid molecules (i.e., as verified by RDKit). Note that the LLM outputs text which is later converted to images via RDKit, so the relationships between the children are more subtle than they appear when rendered as images. In the case of prompt D, the "backbone" appears to be interpreted by the LLM as the center of the molecule, which is never modified. Instead, functional groups are attached to the methyl group on the right-hand side of parent (a) and to the left-hand side of parent (c).