1-Chloro-4-ethenyl-2-fluoro-benzene was applied: in hexamethyldisilazane lithium (LiHMDS)-promoted hydroboration of alkynes and alkenes with pinacolborane ; in stereoselective gold(I)-catalyzed vinylcyclopropanation via generation of sulfur-substituted vinyl carbene equivalent ; in preparation of indazolyl pyridinones and related heterocycles as kinase inhibitors for the treatment of cancer ; in quantitation of ERK1/2 inhibitor cellular target occupancies with a reversible slow off-rate probe ; in ironcatalyzed carboamination of olefins: synthesis of amines and disubstituted β-amino acids ; in development of a practical synthesis of ERK inhibitor GDC-0994 .