As mentioned in section 2.5, 2D NOESY NMR was used to obtain NOE peaks for cyclodextrin complexes, providing a cross check for modeling and giving insight on host-guest interactions. As expected, experimental NOEs revealed at least one end of the phenothiazine core is at the secondary face of the host while the opposite end penetrates deep towards the primary face for all but one complex. In addition, NOEs also suggest that the bulky cationic side chain ends of TDZ and TFP guests reside at the primary face of both hosts. The authors speculate that all cationic side chains reside at the primary face of the hosts, but only TDZ's and TFP's bulkier side chains are tightly fixed in the host binding site to generate observable NOEs. To our knowledge, whether the functionalized region of the phenothiazine core for TFP, TDZ, and CPZ reside at the secondary or primary face remains unknown and unexplored, experimentally.