Herein we developed a collagen-based injectable hydrogel crosslinked using bio-orthogonal cycloaddition reaction between furan and maleimide. The furan-collagen developed here has similar thermal gelling properties as that of pristine collagen but is more stable upon storage compared to previously developed thiol-collagens developed for similar purposes. The resulting crosslinked hydrogel is shear-thinning, does not swell or shrink and can retain its shape and size even after prolonged storage in buffer, can be degraded by enzymes in vitro, and is completely resorbable in vivo. The developed hydrogels can be injected in a gel state and retain their injectability and shear-thinning properties up to 48 hours after mixing of the hydrogel components. This is a significant leap forward in the field of in vivo injectable ECM-polymer derived hydrogels since the hydrogel can be prepared in a sterile environment outside of the operation theatre and then brought to surgical room at a relevant time-point. Moreover, the injected hydrogel is capable of quantitative autonomous self-healing after injection. The existing literature on self-healing hydrogels primarily focuses on the recovery of hydrogels in terms of moduli (stiffness) after a shear-stress is applied, and very little endeavors are dedicated to assess the recovery of other crucial viscoelastic parameters such as linear viscoelastic limit, yield strength, stored and dissipated energy at varying strains, or kinetics of regelation. Moreover, in most reported cases the shear-stress from an injection is simulated by applying a single incision where the spread of the damaged zone in the hydrogel is quite limited. In contrast, a hydrogel experiences significantly higher strain and shear-rate over the whole sample during injection through a needle. The developed hydrogel can quantitatively recover, without requiring any external trigger, from such an injection shear-stress not only in terms of moduli, but also regarding the linear viscoelastic limit and thereby, yield strength, and stored and dissipated energy at varying strains. To our surprise, even the kinetics of regelation (crosslinking) turned out to be the same as that of gelation of virgin (non-injected) sample. The observed shear-thinning and autonomous self-healing behaviors were explained by the stress-induced cyclo-reversion of the cycloadduct crosslinks followed by cycloaddition between the reacting partners to reform the gel after injection. This is the first example of an injectable collagen hydrogel which can undergo a complete autonomous selfhealing after injection in terms of several viscoelastic parameters. Due to the challenges involved in mechanophore activation within a crosslinked polymer network by applying a macroscopic stress, supramolecular interactions or reversible crosslinking reactions are often thought to be better choices for designing self-healing hydrogels. However, such hydrogel systems suffer from the risk of swelling in buffer or require external trigger to favor the reverse reaction during the self-healing process. Furthermore, in vitro and in vivo experiments with cells and animal models further demonstrate the usability of the developed collagen furan hydrogels in regenerative medicine. To our knowledge, this is the first example of an injectable, shape-holding collagen hydrogel which undergo complete autonomous self-healing, where cell encapsulation is possible.