The discovery of biomolecular condensates (or biocondensates) and their involvement in the formation of membraneless organelles had a pronounced impact on biology, challenging the conventional picture that cellular compartmentalization is exclusively achieved via membrane-enclosed organelles . Biocondensates play important functional roles for many cellular processes . Furthermore, the possibility to control the phase behavior has fostered applications in materials science and synthetic biology . To fully exploit their potential, and for steering their properties by targeted modifications, a detailed understanding of the driving forces underlying the formation of biocondensates is required. This challenge can best be achieved by a synergistic combination of experiments, theory, and simulations, especially when the computational and experimental data are efficiently integrated.