The three atom mapping methods required the same amount of time of three seconds for the all-to-all mappings of the RHFE set, which translates to 91 mappings with an average of 38.6 atoms per mapping. However, for TYK2 with 120 all-to-all mappings and an average atom count in the mappings of 74, the time difference reaches 18 seconds between the Lomap approaches taking 26 s and the Kartograf approach taking 8 s.