Herein, we presented a comprehensive literature review centered on marine-derived anthraquinones as a unique group of fungal polyketides over the period 2000-2020 from twenty marine fungal genera. A list of 208 anthraquinones that have been reported from different marine fungi that feature a myriad of structural and biological diversities. Investigating such chemo-biological data has implied two remarkable points. First, it was clear that the marine fungi of the three genera Aspergillus sp., Stemphylium sp., and Penicillium sp., are the most creative fungal genera in terms of producing anthraquinones. Secondly, the most investigated bioactivity was cytotoxicity, where a notable number of seventy-two compounds have been evaluated for their cytotoxic activity against planes of carcinoma cell lines, whilst the anthraquinones with antibacterial activity were the second on the list with sixty-nine compounds demonstrated bioactivity against a wide range of microorganisms. Meanwhile, an enormous spectrum of further biomedical potentialities exhibited by these compounds as (antioxidant, antiviral, antifungal, immunomodulatory, anti-inflammatory, …….etc.) have been documented. Such a massive connection between chemical spaces and bioactivities highlights the huge capacity of marine-derived fungi as an attractive biological source that is worth further exploitations with distinguished anticipations for the global pharmaceuticals industries. Additionally, recent advances on the level of sampling techniques, fermentation, synthetic biology, genetic engineering, genome mining, and total chemical synthesis, all are crucial to the success of fungal MNPs as future drug leads (Figures and).