With a maximum loading efficiency of 44.9% for the proposed conditions, the material presents the same efficiency as the spherical material synthesized by chemical precipitation by Hasegawa, which loads flomoxef sodium (an antibiotic). In comparison, hydroxypropyl-β-cyclodextrin has a maximum loading efficiency of 67.26%, which indicates a different application approach aiming for gastrointestinal release . This research targets release in the bloodstream. Compared to the material synthesized by Salahuddin, loading efficiency differs by 40%. However, the hydroxyapatite-Euclea natalensis material was synthesized by chemical precipitation, reducing energy expenditure and cost .