Nuclear magnetic resonance (NMR) and magnetic resonance imaging (MRI) are analytical techniques used to extract information about the structure or composition of a sample noninvasively. Unfortunately these methods are rather insensitive, and in order to overcome the limitations this imposes, hyperpolarization methods have been developed to produce samples with enhanced magnetic resonance signals. Signal enhancements in the order of 10 5 can be achieved for solution-state samples using hyperpolarization techniques such as dissolution dynamic nuclear polarization (dDNP) or parahydrogen-induced polarization (PHIP) . This allows the injection of hyperpolarized probe molecules in vivo, and subsequent imaging of metabolism . One such example is the imaging of hyperpolarized fumarate, which is converted to malate in one step of the Krebs cycle, and acts as a sensitive probe of cell necrosis . This has been demonstrated in preclinical MRI studies as e.g. a method to study tumour response to therapy and image acute kidney injury and myocardial infarction .