In the following analysis, we will use the notion of "effective time" in coarse-grained simulations. Because coarse-grained force fields represent a significantly smoothened energy landscape (i.e. fewer degrees of freedom), 58 kinetics are considerably faster relative to atomistic simulations. A common rule of thumb is to use a speedup factor of 4 when using Martini. Note that this factor is highly system-dependent and even varies at the molecular level. However, we here use a conversion factor of 4 in order to compare across systems. Consequently, we compare 1 µs of atomistic simulation to 250 ns of coarse-grained simulation.