The increased probability of a higher ∆E strain in pure and cocrystal structures suggests that the close-packed nature of typical crystal packing provides greater stability of molecular distortion than interactions in the pores of the CS framework. It should be noted that Thompson's study excluded molecules with potential for intramolecular hydrogen bonding, while the molecules in this study have greater potential for hydrogen bonding. These strong interactions could also lead to a higher ∆E strain .