Experimental details including materials and methods, the synthesis procedures for LA-EG4-DiMan and LA-EG2-EG2-OH ligand and their 1 H/ C NMR and LC-MS spectra, determination of glycan conjugation efficiency and valency, surface footprint calculation, protein production, labeling and HR-MS characterization, fluorescence spectra of GNP quenching assays, ITC data and the original data of viral inhibition studies. This material is available free of charge via the Internet at .