Even though there were small differences in the viscosity measurements, all polymers showed a viscosity below 110 Pa*s at 125 °C for the samples containing drug and plasticizer and 130 °C for the samples containing only the drug. In addition to the melt viscosity, the Tg of the above-mentioned samples was studied (Figure ). This can result in problems in sample preparation, as reported previously due to the viscous and sticky nature of the blend. In general, all printed drug-loaded scaffolds showed hygroscopic character and had to be stored at low humidity to prevent water absorption and the samples getting sticky, which made handling challenging. On the other side, for using them as sublingual drug delivery vehicle, the hygroscopic character is beneficial, as it would allow the scaffold to stick in the mouth floor or the cheek while dissolving and releasing the drug. Comparable to the fiber meshes printed with the polymer-plasticizer blends, drug loaded samples were fabricated into scaffolds with 10 layers in each direction (0° and 90° fiber orientation) and 1.5 mm fiber spacing. MEW printing was tested by increasing the temperature in 5 °C steps until fiber extrusion was observed. When testing the printability of the samples containing polymer and IND with and without plasticizer, it was observed that all samples, except A-PentOzi-A, were printable from 125 °C onwards (Figure , Supporting Information Figure ). The best stacking was achieved at either 130 °C or 135 °C, depending on the polymer. Additionally, the fiber stacking of the samples containing triethyl citrate was overall better than for the samples without the plasticizer.