A one-minute LC-vDMS-SIM/MS method for quantification of 11 drugs of abuse (excluding THC/CBD) was developed, in addition to a four minute method to confirm and quantify the cannabinoids THC, CBD, and metabolites. The performance of these assays was compared to liquid chromatography methods using the multiple reaction monitoring mode (LC-MRM/MS). LC-MS grade acetonitrile was obtained from VWR Chemicals (Fontenay-sous-Bois, France), methanol and formic acid from Fischer Scientific AG (Reinach, Switzerland). UHPLC-MS grade water was obtained from Huberlab (Aesch, Switzerland).