• Senolytics are small molecule drugs that specifically provoke senescent cell elimination by aiming survival pathways and anti-apoptotic systems, antibodies and antibody-mediated pharmaceuticals. Unlike SASP inhibitors, senolytics can be successful following intermittent rather than continuous administration. • Senomorphics are a wide range of agents, which suppress senescent phenotypes without killing cells. • Gene therapy approaches edit the cells' genes in order to enhance their resistance to aging, senile diseases, and to prolong the lifespan of the organism. 410, 411