Clusters generated to analyse variant bioactivity distributions in Figure were computed for subsets including all compounds tested on at least two variants and a Butina cluster cutoff of 0.5. Clusters generated to analyse the full-panel bioactivity differences of compounds in the EGFR (P00533; Figure ), BRD4 (O60885), and IDHC (O75874) bioactivity analysis subsets were computed for said bioactivity analysis subsets with a Butina cluster cutoff of 0.7. For HIV-1 RNaseH-RT (Q72574), the cluster cutoff was set to 0.5.