Compared to the non-treated cells, while 15c at MIC and 2× the MIC induced 37% and 59% decrease in biofilm mass, 16c exerted 46% and 70% decrease in biofilm mass, respectively. In contrast, standard antibiotics, amphotericin B and fluconazole, showed closely similar antibiofilm activity against A. fumigatus and C. albicans with 44-50% and 65-68% decrease in biofilm mass at MIC and 2× the MIC, respectively (Figures and). Overall, 15c and 16c displayed remarkable anti-biofilm activity against both bacterial and fungal strains, which were comparable to standard antibiotics.