Crossing the BBB is an essential factor for chemical reagents to be utilized in the brain. Thus, the brain uptake of the AQ series was predicted by the parallel artificial membrane permeability assay adapted for the BBB.64,65 As summarized in Table , most of the molecules selected in this study were expected to have sufficient BBB penetration with a -logPe value below To assess the aggregation propensity of Aβ42 species treated with Alo and light in the brain, we conducted histochemical studies on the brain samples injected with Alo-treated Aβ42 species.