Additionally, the success rate of finding a good pose among all poses is only 65%, hinting at a sampling issue. Indeed, visual inspection of all generated poses suggests a low structural diversity. However, increasing the sampling by using 1000 GA runs increases the success rate by only 1% (Supporting information, Table ). These results are lower than what has been reported by Scarpino et al., who found a success rate of 55% for covalent docking with AD, and may be due to different procedures to generate randomized initial ligand conformations.