Computational benchmarks are important to drive the progress of computational methods. Measuring enrichment factors in virtual screening, or benchmarks like Guacamol represent sensible benchmarks and have been useful to make progress, however, also here "Goodhart's law" has to be invoked, as they represent only proxies, and still do not capture the full intricacies of molecular discovery. We nevertheless recommend the following steps for benchmarking the approaches described in this work: