Noteworthy, the dimethoxy derivative (48) was highly active against the MRSA strains showing MIC values of 7.8 and 3.9 μg/mL, respectively, and was moderately active against the Vibrio strains with MIC ranging from 15.6 to 62.5 μg/mL . The same study mentioned that a molecular docking study was conducted to explain the cause behind this antimicrobial activity revealing the least binding energy of compound 48 with both AmpC β-lactamase and topoisomerase IV . On the other hand, its parent compound 47 displayed potent larvicidal activity against the larvae of Aedes aegypti with an IC50 value of 1.8 μg/mL .