Pesticides are substances extensively applied in agriculture to control pests, diseases, and weeds. By safeguarding crops, these compounds enhance production yields and profitability for farmers. However, the various methods of pesticide application result in both direct and indirect exposure, leading to adverse effects on human health and the environment. Neonicotinoids, a relatively new class of pesticides on the market, have become the most widely used insecticides worldwide . Their prevalence highlights the critical need for regulatory oversight. They were rapidly the target of authorities for one major environmental issue, as the origin of the colony collapse disorder (CCD) in honeybees, first reported in 2006 and invertebrate aquatic species (Josephus F. . These compounds act as nicotinic acetylcholine receptor (nAChRs) agonists. They bind to the receptors on a post-synaptic membrane with a high affinity, leading to neural hyper-activation and consequential insect's death . Despite the environmental aspect, neonicotinoids impact on human health has been recently studied and demonstrated to be involved in breast cancer development by over-expressing aromatase enzyme (CYP19) .