ELIDIS is also versatile: we demonstrated detection of five different antibodies, including a bispecific antibody, by simply changing the recognition element conjugated to the DNA strand. Finally, the platform can be easily multiplexed by using different antibody-responsive reactions, with different DNA sequences rationally design employing computer-aided design and commercially available disposable electrodes modified with different capture strands. Thanks to the above properties, we believe that the use of modified synthetic DNA strands in combination with enzymatic amplification and electrochemical detection can open a new avenue for the development of highly sensitive platforms for antibody detection.