This approach of molecular exploration has been widely implemented to describe the structural composition of bioactive molecules and has been used in the study of NPs. Possible combinations of heteroatomcontaining ring systems have also been predicted, with a probable prediction of an activity for a biological target, under the categories of active, inactive, or undefined. Herein, we used the results reported by Ertl to extract and compare potential biologically active ring systems (so-called "Magic Rings") and search for similarities among NAPROC-13 and reference databases. Ertl categorization classifies a ring system for a preferred family target if the report includes at least twice as large as the next target class, on the other