With the initial thermolabile crosslinker design now established, future catalyst modifications are limited only by our ability to synthesize slight variations of this underlying motif. Going forward, it should be straightforward to alter the identity of the templated functional groups to increase activity, such as changing the primary amine to a secondary amine. Work along this vein is under way. One can further imagine shortening the distance between acid-base pairs by replacing the benzylamine groups with a longer phenylethylamine, or, conversely, lengthening the distance by extending the crosslinker. As spatial precision is critical to harnessing cooperative interactions, we anticipate that these subtle adjustments will have dramatic effects on catalytic activity. Finally, given the orthogonal post-synthetic reactivity of carboxylic acids and amines, our templated sites can serve as a convenient and versatile entry point to more complex active sites, beyond simple acid-base pairs.