We report a resource-efficient hybrid SnO nanoflower-Laser-Induced Graphitic carbon (LIG) chemiresistive sensor platform for VOC headspace sensing at ambient temperature. This early demonstration of SnO nanoflowers as VOC-sensitive MOX nanomaterials also features additive integration at low mass-loadings with direct-written laser-graphitized 3D porous carbon contact electrodes. The SnO-LIG sensors demonstrate responses characteristic of p-type semiconductors, with increases in device resistance when exposed to methanol headspace vapor (∼5% at 150 ppm, ∼35% at 4100 ppm) or other reducing VOCs in a versatile, low-cost custom chamber. Density functional theory simulations provide key information on the interaction of VOC molecules and water at SnO surfaces with different surface orientations. The (101) surface shows stronger, but still not chemisorbed, interaction energies and a notable oxidation of surface tin sites, whereas the (001)