As shown in figure , this models fits very well with the experimental data. In particular, the observed kinetics can be interpreted by the presence in the experimental sample of vesicles that decay according to two well separated time regimes (Table in the SI). The first regime consists of vesicles that, at an early stage, experience, on average, a significant number of open pores (N=7-9). These vesicles discharge very rapidly, with characteristic times in the µs regime. The second, instead, is related to vesicles that have, on average, less than one pore present (N=0.1-0.2).