A Constellation plot is a hybrid approach of visualization of chemical space and substructure analysis. As described in detail elsewhere, the main analog series of a compound data set are generated. The structural similarity of the analogs series is represented in a two-dimensional representation of chemical space such as t-SNE. Constellation plots represent a method to visualize and analyze StARs (Structure-Activity Relationships) in chemical space . Following the methodology proposed by Naveja and Medina-Franco, constellation plots were built .