That said, we do worry that the def2-ma-SVP affords interaction energies that are too far removed from those obtained in higher-quality basis sets, and that the BSSE inherent in double-ζ calculations may skew the conformational landscape towards compact structures, which exhibit larger BSSE and thus ostensibly stronger interactions in small-basis calculations. It is also worth considering that the accuracy of DFT for small-molecule van der Waals complexes does not seem to extend to complexes in the 150-atom size regime, so the quality of supramolecular DFT "benchmarks" is uncertain in sizable protein-ligand models. These are important questions to explore in future work. For now, we simply note that the conventional "chemical accuracy" standard of 1 kcal/mol may be overly conservative for the present purpose.