All systems were successfully parameterized using a combination of the general SMIRNOFF Sage 2.0 force field and TIP3P water parameters. The Amber ff14sb protein force field, previously ported to the SMIRNOFF format, was also used to obtain reference parameters when parameterizing proteins. The results of the monomer generation and testing can be found with the final monomer templates for all systems located in the monomer_generation/json_files directory. a Where possible, larger systems were created up to 81810 atoms to benchmark large homopolymer systems. Some systems show two numbers where the first indicates the original polymer size and the second the size of the larger polymer built to benchmark the toolkit parameterization code. b Proteins with only canonical amino acids and no additional ligands were used to compare to previous Open Force Field toolkit PDB loading.