strong antioxidant potential and anti-lipid peroxidation action . Recent studies have found that silybins possess cytotoxic activity in a mouse model of prostate cancer , in the human nonsmall-cell lung carcinoma H1299, H322 and H460 cell lines , and the SW480 human colorectal cancer cell line . In addition, they have proven cytotoxic potential in bladder, skin, prostate, colon and lung cancers by a mechanism of regulating the cancer cell cycle, apoptosis and autophagy, as well as inhibiting tumor-inducing factors . Thus, structural modifications of silybin could provide further interesting information on silybin's applications.