As preparation, we simulated the T4 lysozyme system with 3-iodotoluene for 90 ns, saving the positions every 0.2 ns, thereby saving a total of 450 tra-jectory snapshots. We used these snapshots to facilitate our comparison of the acceptance of MC moves and NCMC moves. For 3-iodotoluene, our goal is to assess overall acceptance, and see whether substantial rotational moves are being accepted with reasonable frequency -in contrast to our work on toluene (Section 2.6) where we were interested in estimating populations in order to ensure that our approach converges to the correct populations. Thus at the start of each MC or NCMC move attempt we randomly pick a starting trajectory snapshot to use as a starting point for a new move proposal. This allowed us to have a variety of starting points for our move proposals, while also ensuring that we were assessing the performance of move proposals with equivalent environments. For MC we performed 10 trials, each consisting of 2,000,000 move attempts where each move is instantaneous. For NCMC we performed 7 trials, each consisting of 2000 move attempts; each move consisted of 6500 NCMC switching steps.