Chemoinformatics is founded on the concept of combining ideas from chemistry with computational techniques. Advances in the field are often achieved by merging previously ignored ideas and can be easily published and distributed via the internet. Yet, among the many techniques available, there is often no clear best method. Often the best results can be achieved by combining different methods, at the cost of increased computational resources. While many individual methods can be used without programming knowledge, the automatic combination of different methods is difficult even with expert domain knowledge.