With optimal conditions in hand (see Table , Entry 1), we tested the generality of the onepot deoxygenative alkylation protocol (Figure ). First, we combined tetrahydrofuran as C-H donor with a diverse set of aromatic aldehyde-derived 4-trifluoromethyl-phenylsulfonyl hydrazones, as shown in Figure . Electron-poor, -neutral and -rich aromatic aldehydes successfully served as radical acceptors, affording the corresponding homobenzylic ether products in good isolated yields (3-20, 43-86% yield). Notably, our method tolerates well the presence of halogen groups (7-12), which are useful synthetic handles for further manipulation with classical transition-metal-promoted cross-coupling reactions. Next, we found that a diverse range of heteroaryl aldehydes, such as picolinaldehyde (21), nicotinaldehydes derivates (22-24), indazole (25) and indole (26) were compatible with our reaction protocol. Also, several aliphatic aldehyde-derived sulfonyl hydrazones were subjected to our reaction conditions and afforded the targeted C-H alkylated products, albeit with diminished yields (34-45%, 27-29). To further demonstrate the synthetic value of our method, 4-trifluoromethylphenylsulfonyl hydrazones of several drugs and natural products, such as probenecid acid (32, 65%), estrone (33, 38%) and ataluren (34, 77%), were successfully engaged as coupling partners. We subsequently examined the scope of C-H donors in our synthetic process and found that a diverse set of readily available saturated heterocycles were viable for coupling with our model aryl sulfonyl hydrazone 1a (Fig. ). Different cyclic and linear ethers were efficiently alkylated to deliver the corresponding homobenzylic ether products in good yields (35-42, 41-58%).