Nipah henipavirus is a bat-borne virus that can infect humans and other animals. . Nipah virus infection is a zoonotic disease that is spread from animals to humans . It can also be spread through contaminated food or from person to person . It causes a variety of symptoms in infected individuals, ranging from asymptomatic (subclinical) infection to acute respiratory sickness and deadly encephalitis . Nipah virus is a member of the Paramyxoviridae family and the genus Henipavirus along with the Hendra virus, which has also caused disease outbreaks .The Nipah virus genome is a single (nonsegmented) negative-sense, single-stranded RNA with a length of over 18 kb, far longer than that of other paramyxoviruses . The Nipah virus was initially detected in pigs and pig farmers in Peninsular Malaysia in 1998 . Infection outbreaks of the Nipah virus have been documented in Malaysia, Singapore, Bangladesh, and India . The highest rates of death from Nipah virus infection have been reported in Bangladesh, where outbreaks are most common in the winter . Consumption of fruits or fruit products (such as raw date palm juice) contaminated with urine or saliva from infected fruit bats was the most likely cause of infection in later outbreaks in Bangladesh and India . About 700 human cases of Nipah virus had been reported as of May 2018, with 50 to 75 percent of those affected dying . In the Indian state of Kerala, an epidemic of the disease led to 17 deaths in May 2018 . A study of the proteins using bioinformatics tools allows researchers to assess their three-dimensional structural conformation, classify new domains, explore certain pathways to gain a better understanding of our evolutionary tree, uncover more clusters, and assign roles to the proteins . This knowledge can also be used to develop successful pharmacological methods and aid in the development of new drugs to treat a wide range of diseases [10].