As mentioned before, to reduce the applied heat as far as possible, the polymer and drug were extruded in different weight ratios using HME. Since the extrusion was done far below the Tm of IND (160°C) and only for a brief time (approx. 10 min), some residual crystalline drug was still present and visible in the extrudates (Figure ). This was also analysed by DSC and PXRD analysis of the resulting extrudates. In particular, the first heating cycle of the DSC was analysed which is usually not discussed due to the existence of polymer's thermal history that should be removed by heating. However, in this study the residual crystallinity of IND is only visible in the first heating curve of the DSC measurement, because it has a very good glass stability (Class III compound) and usually does not crystalize in the used DSC protocol.