For the custom-synthesized polymers P1 and P2, six different polymer-to-drug ratios were prepared, ranging from 25wt% to 80wt% drug content (Table , Supporting Information Tables ). For comparison, extrudates of IND and the established excipients PVP and P(VPco-VA) were prepared with a drug content of 50wt% and 80wt%. To achieve a sufficiently low viscosity for all POx/POzi based samples the extrusion temperature was set to 140 °C in the first heating zone and between 130 and 120 °C in the second and third heating zones, respectively, with minor temperature adjustments depending on the process flow. The extrudates utilizing PVP as polymer excipients were prepared with 135 °C in the first and second heating zones and 140 °C in the third heating zone. For P(VP-co-VA), the process temperature was set to 140 °C in all heating zones. Unexpectedly, the significantly lower Tg of P1 and P2 did not translate into a correspondingly lower processing temperature over PVP and P(VP-co-VA). This was because, unlike for PVP and P(VP-co-VA), the viscosities of P1 and P2 just above their Tg values were still too high for extrusion. On the other hand, due to a sufficiently low viscosity of all polymers at the specified process temperatures, it was possible to keep process temperatures below the melting temperature of IND (Tm = 161 °C, Supporting Information Figure ), which helps to prevent degradation of the drug. It is important to note that the preparation of ASDs below the Tm of the drug is possible, if the process temperature is above the solubility temperature of the drug in the polymer matrix. Detailed information about the process parameter for every sample is listed in the Supporting Information (Table -Table ).