The catalytic reduction of alkenes using a Ni foam and acidic water, as hydrogen source and as electrolyte, was developed and further optimized for environmental performance and safety by using screening life cycle assessment and physical and biological hazard assessments. Excellent to moderate yields can be obtained from a variety of tri-, di-and monosubstituted enones and alkenes. The system requires an organic cosolvent, and two solvents, with minimum hazard profile, EtOH or n-BuOH, were identified to enable the catalytic reaction. The latter was particularly important when substrates with low solubility were used. The recyclability properties of the Ni foam were assessed, showing a constant performance for at least 15 runs. The physical and biological hazard assessment informed about a trade-off between safety and toxicity when comparing the use of the Ni-mediated electrochemical method reported here with that of the conventional Pd/C and H2 gas. Interestingly, despite the abundance of nickel vs palladium being a driving force for using the electrochemical method, the screening LCA results indicate that the Pt counter electrode would need to be reused more than 600,000 cycles, to arrive at an estimated lower impact in the resource use category compared to the Pd/C reaction system. Alternatively, the Pt counter electrode may be exchanged by a carbon-based one, which despite a lower stability under the reaction conditions, and therefore limited recyclability, could present a lower environmental impact. In addition, the screening LCA identified additional hotspots, mainly related to energy use, that should be considered in future applications of the Ni-foam method to improve its environmental performance further.