where 𝜖𝑖 and 𝜎𝑖 are the strength (in kJ mol -1 ) and size of 137 bead 𝑖 (in Å), respectively, and 𝑟 is the distance between 138 two beads. 𝐸 excl.vol. is turned off for beads connected by at 139 least two bonds using the "bondCutoff" parameter. This model 140 mimics a "good solvent" case, where solute-solvent interactions 141 dominate solute-solute interactions.