Macchia et al. have developed a label-free biosensor based on an electrolyte-gated organic thinfilm transistor (EGOTFT) for detecting C-reactive protein (CRP) in human saliva. CRP is a key biomarker for inflammatory processes and is commonly monitored in clinical settings. The EGOTFT biosensor is functionalized with a self-assembled monolayer (SAM) of capturing anti-CRP proteins, allowing for ultra-high sensitivity and selectivity. The biosensing platform is also compatible with low-cost fabrication techniques and is suitable for detecting various biomarkers.