The nature of the surfactant was also screened using this new ligand. Surprisingly, best results were obtained using very inexpensive aqueous sodium dodecylsulfate (SDS; Table , entry 6; 2 wt % in water), an anionic surfactant, rather than nonionic amphiphiles (e.g., TPGS-750-M, Savie, etc.) previously found to be the most effective for Sonogashira reactions. Scheme 2 provides several representative examples resulting from the use of (n-Bu2N)3P together with a relatively low loading of a Pd(II) salt in Sonogashira couplings. These include several examples featuring late-stage functionalization and attest to the not only the effectiveness of this catalyst and the environmental friendliness of the conditions involved (i.e., in water), but also the far less costly nature of this new ligand system.