Based on the structures of the molecules in SAMPL7 as compared to SAMPL6, we suspect that hydrogen bonding plays a more important role in the solvation of the SAMPL7 molecules. From the work of Chen and Siepmann we know that water-saturated 1-octanol has larger hydrogen bond aggregates as compared to neat 1-octanol, which likely results in the larger effect of water in SAMPL7 as compared to SAMPL6. As a consequence, we find that effect of inclusion of water is dependent on the solute. While we agree that methodological differences and the choice of force field are very important, the result are also sensitive to the inclusion of water in the octanol-rich phase.