"During the past two decades, enormous efforts including chemical total synthesis, biosynthesis using cell suspension cultures of Taxus species, and semisynthetic route using baccatin III or 10-deacetyl baccatin III isolated from needles of Taxus species trees as starting material, have been made to relieve the short supply of Taxol due to its low accumulation in Taxus plants (~0.01% dry weight)." Yang, C., et al. 2024 . Jinfa, DU., et al. in April provided a review regarding missing CYP450 enzymes involved in paclitaxel biosynthesis. The authors reported the works of Jiang, et al. characterizing missing enzymes T9αH1 and TOT1, which led to the reconstitution of paclitaxel intermediate baccatin III in tobacco by co-expressing nine core genes seen in . in May published a review regarding the enzymes impacting paclitaxel oxetane ring formation at C4, C5, and C20. Gene clusters affecting the biosynthesis of intermediate baccatin III, as well as "two studies successfully achiev heterologous biosynthesis of baccatin III by transient expression in tobacco" from paper .