Targeted data analysis (MRM-HR) was performed using SCIEX OS version 3.0.0.3339. Regardless of the MS mode of acquisition, extracted ion chromatograms for SWATHonly (MS 1 level) and MRM+SWATH (MS 2 level) were extracted using the default window of 0.02 Da as recommended by SCIEX. Chromatograms were integrated by the AutoPeak method and smoothed using noise filter algorithm with the Low option. Concentrations were calculated for all compounds detected in non-spiked SRMs by the use of standard addition method.