Different supercharging additives (m-nitrobenzyl alcohol m-NBA, imidazole, propylene carbonate and ethylene carbonate) have been tested at different source temperatures (to reduce the build-up of SC agents). The optimized conditions where no shift of ion mobility profile is observed were 0.25% m-NBA at 280 °C. On the course of this work, we noticed that, although the trends reported here were consistently observed, the actual values of CCS and unfolding voltages of extracted components (see MCR-ALS procedure below) were actually very sensitive to the ambient conditions. All results reported here were recorded on final experiments carried out in a single day.