Ligandability assessment. Ligandability assessment is done to gauge the likelihood of ligandable cavity presence within rational distance of the residue within limits of standard small molecule dimensions. Whereas for the simplistic ligandability assessment, a distance threshold of 10Å was set for determining ligandability of a covalent site, to minimize false-positive rates, this threshold was set to 9Å for the advanced ligandability platform. The distance threshold is set based on the maximum of the shortest distance computed from pocket surface to covalent residue across three datasets; covalent sites of 1,647 covPDBs, 230 apo-covPDBs and mock sites of 90 cryptic-PDBs(Figure ).