We then quantified the statistical weight of the different exchange mechanisms in the global equilibrium dynamics of the systems (see Methods for details). We classified the events tracked in the matrices as done in Figure (to ease the comparison, we used the same threshold sizes A and E defined for the M model, also for the BTA systems, complete data in Figure in the SI). To simplify the analysis, we now group all the exchange events under two main inter-assembly communication mechanisms: (i) via exchange of small entities (size<E) and fragmentation/coalescence of medium-size aggregates (E <size< A), or (ii) via fragmentation or coalescence of large molecular entities (of size > A). Referring to the illustrative diagram of Figure , (i) encompasses all events in the yellow, red and green areas, while (ii) identifies the events pertaining to the blue area. According to such a classification, this analysis estimates that ∼ 74% of the exchange events in the BTA system at high-temperature (T = 340 K) involves only monomers and oligomers, while inter-fibres communication via fragmentation/coalescence contributes by ∼ 26% (see Figure : gray vs. blue columns in the inset). Decreasing the temperature to T = 320 K, we observe an intermediate behavior. Under such conditions, the dynamics of the system is controlled by exchange of both small (∼ 60%) and large species (∼ 40% -see Figure in the SI). The exchange of monomers and smaller fragments becomes then less relevant in the inter-fiber communications at T = 300 K for the BTA system. In such conditions, our simulations indicate that small exchanging species give a minor contribution to the molecular communication in the system, while fragmentation and fusion of longer fibres become dominant (Figure : gray vs. blue columns at ∼ 17% vs.