Figure : Binding conformation of hydroxychloroquine that touches the interaction points between the Spike and ACE2. This binding conformation is referenced as the 6th mode in Figure Figure : Binding conformation of Azithromycin that touches the interaction points between the Spike and ACE2. This binding conformation is referenced as the 4th mode in Figure Discussion Based on the binding results provided above, hydroxychloroquine by itself appears to be ineffective in directly inhibiting the SARS-CoV-2 spike-ACE2 interaction. Instead, it seems to serve to increase the acidity of the ACE2 system in the interaction between the ACE2 and SARS-CoV-2 spike that could in many cases result in the degradation of the spike, and potentially the discontinuation of the virus' ability to spread further.