General Information. All experiments were monitored by analytical thin-layer chromatography (TLC). TLC was performed on pre-coated plates. After elution, the plate was visualized under UV illumination at 254 nm for UV active material. Columns were packed as a slurry of silica gel in petroleum ether (PE) and equilibrated solution using the appropriate solvent system. All reagents were commercially available unless otherwise noted. All reactions were carried out under a nitrogen atmosphere in dried glassware. Air and moisture-sensitive liquids and solutions were transferred via a syringe. All solvents were dried and distilled by standard procedures. Solutions were concentrated under reduced pressure by rotary evaporation. Chromatographic purification of products was accomplished on silica gel Si 60® (300-400 mesh). All heating reactions were heated by a metal sand bath (WATTCAS, LAB-500, ). Nuclear magnetic resonance spectra were acquired on a Bruker AMX 400 (400 MHz, and 100 MHz for 1 H, and 13 C respectively). All 1 H NMR spectra are reported in parts per million (ppm) downfield of TMS and were measured relative to the signals at 7.26 ppm (CDCl3) or 2.50 ppm (DMSO). All 13 C NMR spectra were reported in ppm relative to CDCl3 (77.16 ppm) or DMSO (39.52 ppm) with 1 H -decoupling. Data for 1 H-NMR are reported as follows: chemical shift (δ in ppm), multiplicity (s = singlet; brs = broad singlet; vbs = vary broad singlet; d = doublet; t= triplet; q = quartet; quint = quintet; sext = sextet; m = multiplet), coupling constant (Hz), integration. Data for 13 C-NMR are reported in terms of chemical shift (δ in ppm), multiplicity, coupling constant . Melting points were measured on a WRS-1A digital melting point apparatus and are uncorrected. High-resolution mass spectrometry (HRMS) was obtained using a Finnigan MAT 8200 instrument with a Q-TOF (AB SCIEX X500R with ESI source, and Agilent 7250 with EI source), which combines quadrupole precursor ion selection and a high-resolution accurate-mass (HR/AM) Time of Flight mass analyzer to deliver mass accuracy.