One of the challenges that beginners in computational chemistry face is the use of high-performance computing (HPC) clusters, as it commonly requires functional knowledge of shell (i.e. command line) environments. This technical proficiency will often restrict some users to particular GUI-based QM software. CalcUS enables the use of the full potential of remote HPC resources (i.e. clusters) in the same user-friendly interface developed for the local resources. When launching new calculations, the user can simply specify a remote cluster (previously configured) to be used. CalcUS then manages remote job submission of calculations, as the user would through a shell. It handles file upload and job submission to SLURM scheduling software, which is widely used on HPC clusters. The user simply needs to provide a submission script template for each HPC cluster. This approach provides good flexibility for choosing the parameters of the jobs to be submitted and allows support for a variety of cluster configurations.