In this study, our objective was to elucidate the susceptibility to biodegradation of newly prepared hybrid polymer networks based on hydrophobic ester-urethane telechelic macromonomers, PEGylated fibrinogen, and methacrylated L-DOPA. We examined the chemical structure of the hybrid components of final polymer network, as well as we determined the parameters of hydrolytic and enzymatic degradation, such as changes in chemical structure, water uptake, mass loss, and the pH of the degradation medium. We also assessed physico-chemical properties of the final photocured materials as a function of the Chempur (Poland). Fibrinogen was purchased from SEGENS (France). HEMA was used after distillation under reduced pressure; all other reagents were used as received.