In order to explore the topics mentioned above further, the following is a Spanish handbook that addresses concepts and tools of Chemoinformatics with applications in drug design. In recent years, there have been several contributions to teaching Chemoinformatics and machine learning for chemists in an organized and formal manner. However, it is still necessary to improve the teaching and dissemination of the applications of Chemoinformatics in Latin America. This is to promote international collaboration and technological competence by equipping professionals with advanced skills in handling computational tools for chemical data analysis. This not only benefits academic research but also the chemical and pharmaceutical industry.