Compounds with molecules containing high bond dissociation energies can be flagged for persistence assessment and subsequent inclusion as PMT/vPvM if each of the M and/or T criteria are met. Biodegradability models can be used to quickly provide relevant information about the persistence of many substances or the presence of many persistent substructures, pending further investigation and confirmation by experimental studies . However, the applicability domain of available models is dependent on their training data, resulting in unreliable predictions for compound classes that may not be covered yet .