We have presented here the validation of our flexible ring docking method. The method has been implemented and validated in AutoDock-GPU, extending the original approach implemented for AutoDock3 and AutoDock 4.2. Using an anisotropic ring closure potential provides a robust approach to dock cyclic molecules containing one or more flexible rings consisting of 7 or more atoms, and addresses most of the limitations of the first implementation. The results show the performance of the method is related to the complexity of the search, while the anisotropic potential does not alter the scoring function value of converged systems. This is further reinforced by the responsiveness of these systems to increased numbers of evaluations, which are shown to improve performance. This additionally means the method performs very well on the smaller ring systems most prevalent in druglike molecules. Finally, we show this method is capable of handling challenging multicyclic systems of clinical relevance. The method is compatible with all the other protocols available in the AutoDock Suite, therefore we recommend, and internally use, this method as a standard part of our docking pipeline. The automated preparation and simulation steps make this method suitable for high-throughput applications.