An Accessible-category is a binding site residue that shows high percentage of interaction but low to moderately favorable interaction energy. Targeting Accessible residue category can be easier than the Transient-category due to its high accessibility, however, it might have low improvement in the binding affinity of ligands. This is mainly because Accessible residues will account for more lipophilic interactions than electrostatic ones (Phenylalanine, alanine, valine, … etc). Finally, the Non-hotspot-category, which is a binding site residue that shows low to unfavorable interaction energy and low percentage of interaction. Non-hotspots are the least prioritized, if targeted they might either show slight improvement or decrease in binding affinity due to clashes. However, any binding site residue that falls in one of the four categories might be essential for selectivity purposes. FMOPhore provides quantitative and qualitative heatmaps of the key interactions to identify hotspots in functional binding site. By comparing the ensemble of heatmaps and FP-score plots for related protein family it is possible to determine the selectivity-hotspot regions.