The field of bioelectronics is rapidly expanding. In particular, there is now a drive to merge electronics with biology, to input electrical stimuli, and modulate disease and is termed bioelectronic medicine. The limitations of modern bioelectronics go beyond size and performance, they are limited by the electronics themselves. In that, there is a mismatch between the material properties, the 3-dimensional (3D) characteristics and plasticity of biology which prevents the integration of electronics in biology and can lead to fouling through the body eliciting an immune response. Standard manufacturing processes for electronics produce hard/brittle structures, resulting in the lack of integration with 3D cell constructs. Hence, new 3D processes and materials are required to allow the production of nanoscale, flexible components that merge seamlessly with biological systems. As we learn more about bioelectricity and its importance in organ, tissue and cellular functions, innovative bioelectronics are required to sense and actuate bioelectricity.