As shown, it is possible to determine the equilibrium values of bonds and angles by averaging over different conformers generated by ETKDG for all bonded interactions within one molecule. The parametrization based on Swarm-CG provides these values solely for the bonded interactions within individual fragments, as not every macromolecule can be sampled through MD simulations in an appropriate timeframe. Hence, the subsequent approach was employed to combine these two sets of parameters. The equilibrium values of bonds and angles, as well as dihedral angles are taken from ETKDG, to prevent a mixing of these values with those from Swarm-CG. The force constants obtained from Swarm-CG are employed for the bonded interactions within the fragments, whereas standard force constants are utilized for the interactions between different fragments. A comparison of the equilibrium values generated by Swarm-CG and ETKDG can be found in Section S6 of the Supporting Information.