Introduction of the hydrophobic tail into the system has the additional effect of changing the head-solvent interactions, the solvent-solvent interactions, as well as the solute conformational energy. However, these reorganization effects have exactly canceling energetic and entropic components as described in Sec. II E (see Eqs. 23 and 24). Fig. shows the total solute-solvent energy and entropy components of the tail effect, ∆ t E h⊕t,V = ∆ t E t,V + ∆ t E h,V , and -T ∆ t S h⊕t,V = ∆ t F