To show the results of a prove-of-concept example of the above mentioned possibilities for candidate selection, stringent <-100 DW docking-score thresholds were applied to retain only the highest affinities to A.baumannii LolCE (lead predicted antibiotics). In contrast, those children predicting also high affinities (<76 DW docking-scores) to E.coli LolCE, were skipped (avoid commensal antibiotics). The so downsized abaucin children library was further refined by consensus by selecting for those children predicting also A.baumannii LolCE ADV scores <100 nM (high affinities) and also by taking into account their minimal calculated ligand efficiency LELP parameters. This example of simultaneous filter combinations, predicted the abaucin-children leads 18544 and 34326 (Table and Figure ) Other threshold combinations may be chosen to predict other A.baumannii LolCE children for particular user purposes (4312AbaucinChildrenLibrary.dwar, Supplementary Material). All the abaucin-children in the library targeted similar cavities at the upper part of the A.baumannii LolCE compared to abaucin (Figure ). Most of the LolCE amino acids targeted by 18544 and 34326 were into the E rather than into the C protein, in contrast to those predicted for abaucin docking (Table ). More hydrogen bonds were also predicted into the E protein (3-4) compared with 1-2 into the C protein (Table ). These amino acid preferences confirmed their higher affinity predictions towards A.baumannii E protein at the LolCE complex. Because of the implication of lethal mutants in the upper E region , the similar 18544 and 34326 preferences could be implicated in experimental binding to A.baumannii LolCE to interact with its lipoprotein traffic activity.