When we investigated other descriptors of AP, the molecular weight was the second most important, with a Gini index of 15.2. This is consistent with the concept of "the rule of five," which states that smaller compounds (specifically, less than 500 g/mol) are more likely to be absorbed in the body, and vice versa . We can speculate on the interpretation of other descriptors; however, in this study, we simply selected descriptors based on multicollinearity.