CADD has made clear contributions to identify and advance drug candidates that are now in clinical use. Over the past few decades, and more remarkably in recent years, AI (arguably better called augmented intelligence) altogether with even richer databases is advancing drug research at a tremendous speed. AI has made clear and dramatic advances in SBDD and LBDD. However, the scientific community should employ AI correctly and for the right reasons beyond hype or fashion: ultimately, "fashion vanishes with time but quality (reasoning) is timeless".