Both the capping in eq. 4 and the distance-based screening are performed automatically using our opensource Fragme∩t code. which drives all of the calculations reported here. Fragme∩t implements both distance-and energy-based screening protocols and is interfaced with a variety of quantum chemistry packages. All calculations reported in this work use Q-Chem v. 6.0 as the quantum chemistry engine. Calculations were performed on 28-core nodes (Dell Intel Xeon E5-2680 v4) by packing four subsystem calculations onto each node with seven threads assigned to each Q-Chem process.