Figure is a scatter plot of Vina Scores (docking energy) and LogBB values for all molecules generated during the evolutionary process in Autogrow4. Figures and 1d are similar scatter plots for STgrow4 for molecules generated with LogBB weights, W=1, W=2.0 and W=1.5, respectively. The horizontal dashed line is a threshold of 0.3 for LogBB and the vertical dashed line is a threshold of -9.0 for Vina Score. These figures show that a large number of ligands with high affinity and high LogBB can be generated with STgrow4.