With this modification in place, a 72-gram scale reaction was conducted using a rod-based flow reactor (Figure ). This type of reactor is advantageous as the electrodes do not provide any mechanical integrity to the entire reactor, while maintaining a high degree of mass transport enabling the flexibility to be used in flow or as a continuous stirred tank reactor (CSTR). Based on a limited number of batch experiments, it was determined that running the reaction under constant current conditions at 0.74 A, necessitated a residence time of 45 minutes to achieve >95% conversion of 104. Accordingly, the flow reaction was initiated by first achieving high conversion in batch (45 minutes), followed by the initiation of reagent flow in and out of the CSTR (as depicted in Figure ). The flow reaction proceeded continuously for 14 hours, achieving 84% conversion of 104 and yielding a 65% assay yield of the coupling product 105. Initiation of the reaction proceeded smoothly, with the applied current resulting in an observed cell potential of 1.0-1.4 V over the initial 45 minutes. However, as the flow reaction commenced, the cell potential rose to an excess of 20 V where it quickly stabilized again for the duration of the flow run as shown in Figure . The cell voltage increase as well as slightly lower conversion than batch may indicate that some irreversible processes can take place at the electrodes during the flow electrolysis, presumably because steady state concentration of the RAE is lower than batch. Regarding the impact of cell potential change upon the electrode consumption, the last 500 minutes of the reaction at steady state indicated that the cell potential only increased at a rate of 3 mV/min which is attributed to electrode gap increases as the electrode eroded. Concurrently, an increase in the Ohmic heating in the cell of 0.01 ºC/min was observed, which also supports the increase in cell potential being caused by slow erosion of the electrode. After the ~14 hours of constant operation, the magnesium electrodes were cleaned, dried and weighed and an average of 8% mass loss was observed across the seven electrodes as shown in Figure . Collectively, these findings indicate that impact of electrode corrosion during flow reaction is small; therefore it can be safely concluded that using a sacrificial anode is a viable option for flow scale-up, particularly valuable when developing an appropriate paired electrolysis system is challenging.