The targeted analysis of the high-resolution data was performed using Skyline (version 20.2.0.343). The LOQ calculation was based on the EuraChem Guide (2014). The standard deviation (s0) of n replicate injections (n=min. 6) of a low concentration standard was determined and LOQ values were calculated with the following equation (Equation ): 𝐿𝑂𝑄 = 10 • 𝑠