Compounds synthesized that have suitable physicochemical properties will be screened for target cell toxicity at the Karmanos Cancer Institute, Wayne State University, against pancreatic cancer cell lines and normal, healthy pancreatic cells. Further analyses will be performed to elucidate the effects of the compounds on the cells, using the standard techniques of the Institute and to investigate the proposed mechanisms of action. The testing regimen will be flexible to accommodate findings as the project progresses. Different activity profiles of compounds against the cell lines may suggest testing combinations.