At the beginning of this section, I analyzed the differences in detail between using accurate QMbased conformations and ab initio DFT-D4 conformational strain energies in docking versus the traditional docking scheme. I downloaded two protein structures for the COVID-19 main protease (PDB ID: 6LU7 and PDB ID: 6Y2G ) and a protein structure for the COVID-19 spike protein (with the PDB ID:7BZ5 ) from the PDB database. Docking was performed using all conformations from our FDA-approved drug conformation database and our natural compounds conformation database, applying the QF approach with both Vina and Vinardo scoring functions for all three targets. To enable comparisons, traditional flexible ligand docking was also performed for the FDA database using both Vina and Vinardo scoring functions for these three targets.