We showed above how the molecules were tuned to be synthesizable and varied in an unbiased framework. Now we show that these results also translate to the actual use case -generating drug molecules directly inside a protein cavity. Figure shows a comparison of the baseline model (without any protein) to the actual test case of HSP90. There is almost no change in the similarity with the standard sample size of 300. A comprehensive comparison with 8500 molecules is provided in Figure of the SI, showing some shift in the SSD, but only a marginal increase in the mean similarity score which indicates the consistency of our approach. 61.8% of the generated molecules were found to be synthesizable, which is significantly higher than by random chance alone (24%). This is a notable drop from the vacuum generation (78%). This drop is possibly due to the active FIG. : The mean similarity is 0.44 for the HSP90 active site and 0.43 for the baseline (no protein).