Compound Nomenclature: For simplicity, each compound that is referred to in this manuscript is identified by the following nomenclature: "SAMPL8-X". SAMPL refers to the entirety of the Statistical Assessment of the Modeling of Proteins and Ligands challenges. The number "8" denotes that this is the eighth SAMPL challenge iteration. A number follows, in place of the "X", to identify the unique compound, or drug molecule. As will be described below, there are a total of twenty-three compounds analyzed in this investigation. They are listed in no particular order, and are numbered sequentially from 1 through 23, as "SAMPL8-1" through "SAMPL8-