Alphaviruses encompass the Chikungunya virus (CHIKV), Ross River virus (RRV), and Venezuelan, Western, and Eastern equine encephalitis viruses (VEEV, WEEV, and EEEV). Diverse alphavirus species employ distinct receptors. EEEV is a neurotropic virus that possesses a positive-sense single-stranded RNA. Certain arbovirus infections, which can produce significant neuroinflammation, can cause neurological diseases such as paralysis, encephalitis, ophthalmologic disorders, developmental defects, and in some cases, long-term defects in the central nervous system (CNS) . The Zika virus's congenital brain malformations and the West Nile virus's synaptic dysfunction, which can persist for an extended period and result in cognitive deficits, clearly demonstrate this .