First, we focused on investigating the chloride transport activity of synthetic anion transporters. These are small molecule ligands that can bind anions and transport them across membranes operating via a mobile carrier mechanism, with therapeutic potential in ion channel-related diseases. Here, we used classification to identify whether a transporter can be considered active or inactive based on its EC 50 value. Our analysis includes Fingerprints (Notebook 2) and Mordred descriptors (Notebook 3), where we compare their results and further discuss the results obtained from Notebook 3.