We then examined multigram scale reactions to explore the efficiency of the reaction (Scheme 4), with the products isolated by crystallisation from the reaction mixture. Twelve grams of amide 30 could be obtained in 59% yield using only 5 mol% catalyst, with a PMI of 10 demonstrating the efficiency of the method . Scaling up the synthesis of 4 with in situ catalyst generation gave 16.2 g of amide 4 in 71% yield, with a PMI of 11.8.