To further explore the functional impact of degradation mediated by these control compounds, we next evaluated the cell antiproliferative effect of 93 -95, using the same cell viability assay described above, in BET sensitive RKO WT and CRBN and/or VHL KO/dKO cell lines. We again treated cells with ranging concentrations of compound and measured cell viability normalised to a DMSO control (Figure ). ). ).