The final database contains 2.3 million molecules. The full registration data for the molecules occupies about 7.4 GB of disk space: ∼1 GB for the molecule hashes, ∼3.0 GB for the original mol blocks, and ∼3.4 GB for the mol blocks table. Total runtime for the registration was ∼17.5 hours (26 ms per molecule on average). Query performance was tested using 1000 random mol blocks from the ChEMBL33 data set and the lwreg query command. The median query time was 5.6 ms with 80 % of the queries completing in less than 16 ms. The max query time was 274 ms.