System-dependent artifacts can also arise from system parameters (such as cutoff radius, box shape and/or size). The artifacts are due to finite-size effects which impact computed charging free energies/binding free energies. While such errors do not have a major effect on computed free energies as long as systems remain net neutral or have a consistent formal charge, they become particularly pronounced when the formal charge of a system changes, such as during an alchemical binding free energy calculation as employed by many SAMPL participants. For this reason methods may need to account and correct for artifacts that may not cancel when a formal charge is alchemically inserted in the system. The sign and magnitude of artifacts depend on the methods used to calculate electrostatic interactions.