The average size of CPB NCs in the supernatant (Figure ) decreased to 12.46 ± 5.7 nm, indicating that larger CPB particles preferentially adhered to the ZIF-8 surface during nanocomposite synthesis. This phenomenon can be attributed to the tendency of larger CPB NCs to detach from their ligands and adhere to template surfaces such as MOFs. The primary factor driving this "ligand-exchange" behavior is surface energy; larger NCs possess a greater surface area, resulting in higher surface energy, which they reduce by detaching from ligands and attaching to more stable surfaces. Additionally, as NCs grow, their surface-to-volume ratio decreases, resulting in fewer ligand binding sites relative to their size and weaker overall ligand attachment. Electrostatic interactions also play a role, as larger CPB NCs typically have a more negative surface charge, creating an initial attraction to the positively charged surfaces or metal ions in ZIF. This is followed by ligand exchange between the ligand molecules in ZIF and the positively charged components of the CPB NCs, resulting in chemical interaction. These factors collectively drive the attachment of larger NCs to MOFs with almost uniform sizes.