In the light of the above findings, we hypothesized that presence or absence of multiproduct reactions is the major factor in determining the synthesis route finding performance. As such, we further hypothesized that we should be able to observe changes in the network topology in the function of the presence/absence of multiproduct reactions. To this end we monitored a few network topology descriptors as shown in Figure S??-S??. Interestingly, when comparing the total number of substance-substance shortest paths (see section "Calculating Number of Shortest Paths") for each database configuration, an obvious difference takes shape, as shown in Figure . That is, there is an order of magnitude difference between the total number of shortest paths in configurations with multiproduct reactions included as compared to the others.