We have performed a long-time scale MD simulation to unravel the behavior of a cyclocurcumin derivative, CCBu, interacting with a model lipid bilayer, whose composition mimics a eukaryotic membrane. Equilibrium MD simulation achieving the 660-1200ns time-range and free energy methods have been considered throughout. We have evidenced some specific differences in the behavior of the mixed membrane compared to a simpler DPPC model. In particular, we found that in the case of the more flexible mixed membrane penetration of CCBu is more favorable and stable states in which the sensitizers are placed at the polar head/lipid tail interface exist for both isomers. Furthermore, and differently from the rigid DPPC model, we also found that no concentration dependent phase transition can be observed. Instead, CCBu always assumes a disordered arrangement inside the lipid bilayers, whatever the concentration, a situation which translates in a linear dependence of the average area per lipid metric with the CCBu concentration. The use of CCBu for LAC purposes relies on its capacity to induce membrane perturbations upon photoisomerization. Indeed, we have shown that the bulkier Z-isomer consistently leads to larger values of the area per lipid, which represent a statistically significant trend. Yet, the perturbation induced are relatively small, and are even less important than those observed in the case of the more rigid DPPC membrane. Therefore, we confirm that the inclusion of bulky and rigid peripheral substituents could represent a most valuable strategy to increase the ability of CCBu to perturb lipid bilayers.