Further details on the DBSCAN clustering protocol and cluster statistics are provided in the supporting information (Section S4). Detailed changes in structural distributions, including backbone angle, sidechain angle, and backbone torsion for these three parameter sets are also shown in the supporting information (Figure ). Given that melting point decreases with increasing σ S for all ε S studied (Figure ), the bulkiness of the sidechain beads has a destabilizing effect. Since this destabilization is largely due to stretching of the helix, adjusting the equilibrium backbone bond-bending angle and torsion angle could counter this loss of stability for systems with bulky sidechains. It is also evident that there is an upper limit to ε S for achieving a stable helix. For σ S = 1.778, interaction strengths above ε S = 3.0 no longer increase the melting point.