The complex processes of disease etiology are typically driven by both individual genetic predispositions and the environment. Mounting evidence suggests that environmental causes are predominant risk factors in clinical conditions such as ischemic heart disease, lung disease and most cancers . Complementing genomic research, the study of how genetic changes and predispositions affect gene product functions which may lead to disease, by taking the holistic environmental influences into account is key to bridging the gap between the knowledge of underlying disease mechanisms and epidemiology . The exposome paradigm was first introduced by Wild in 2005, and is defined as the multitude of exposures an individual experiences throughout a lifetime . This encompasses an exceptional variety of dynamic external factors that include environmental-, diet-, social-and lifestyle influences, and associated biological responses; all of which impart specific fingerprints on our internal environment . Exposure to certain man-made and naturally occurring chemicals has long been recognized as a prime risk factor. These xenobiotics have the potential to enter an organism through diet, water, air, cosmetics, personal-care products, plastics, anti-microbial products and many other sources . However, while genome-wide association studies (GWAS) were enabled by technical advancements in the past, the required tools to establish an environmental counterpart are still missing to date .