Starting with a 0.31 M acetaminophen solution in 40 mL of MeCN at 50°C, the EasyMax jacket was cooled at a constant rate (10 °C/min) until a heterogeneous solution was detected via the homogeneity parameter. After waiting for 5 min, the jacket was then heated at the same rate until dissolution was detected. After waiting another 5 min, the cycle was then repeated to verify the solubility and MSZW measurements. The results showed that the clear point of the solution remained constant at 30°C regardless of the cycling event, consistent with the fact that it is a thermodynamic property. However, the cloud point, which is a kinetic property, slightly changed with cycling at 13°C for the first cycle and 15°C for the second cycle. This observation was further supported by the changes in the steady turbidity trend following each nucleation event. Additionally, qualitative analysis (images 3 and 7) demonstrated disparities in the brightness of the crystals, further emphasizing the differences in the turbidity measurements. The reported turbidity value was calculated from the 2D cross section captured by the camera, so the perceived opacity of the solution affected the numerical result. Stochastic factors like number of nucleation events and material sticking to the camera's sight region could also influence the absolute value. Thus, binary delineation of homogeneity served as the primary parameter for feedback control during the transition between clear and cloudy states. When the experiment was repeated at a different cooling rate (3 °C/min), the cloud point changed as a function of the cooling rate (13°C at 10 °C/min and 21°C at 3 °C/min) while the clear point remained constant (30 °C at both 10 °C/min and 3 °C/min), supporting the idea that the clear point is deterministic while the cloud point is stochastic, see SI for details. The automated feedback control employed in this experiment allowed for rapid, autonomous solubility and MSZW measurements like existing clear point/cloud point approaches (e.g., Crystal16®). We envision that by adding a dosing unit to the existing workflow, automated solubility and MSZW curves could be obtained across a range of concentrations and temperatures.