In this paper, we analyze data from the CAS Content Collection to summarize the research progress in Parkinson's disease. We examine the publication landscape in the area in effort to provide insights into current knowledge advances and developments. We review the most discussed and emerging concepts and assess the strategies to combat the disease. We explore the genetic risk factors, pharmacological targets, and comorbid diseases. Finally, we inspect clinical applications of products against PD with their development pipelines and efforts for drug repurposing. The objective of this review is to provide a broad overview of the evolving landscape of current knowledge regarding the class of PD, to outline challenges, and evaluate growth opportunities to further efforts in combating the diseases.