A machine-readable submission file format was specified for blind submissions. The submission files included fields for naming the method of the computational protocol, listing the average compute time across all of the molecules, detailing the computing and hardware used, listing the major software packages and the versions that were used, and a free text method section for providing the detailed documentation of each method, the values of key parameters with units, and to explain how statistical uncertainties were estimated. There was also a field where participants indicated whether or not they wanted their submission formally evaluated. In addition to their predictions, participants were asked to estimate the statistical error (expressed as a standard error of the mean (SEM)) associated with their predictions, and the uncertainty of their model. The SEM captures the statistical uncertainty of a method's predictions, and the model uncertainty corresponds to the method's expected prediction accuracy, which estimates how well a participant expects their predicted values will agree with experiment. Historically, model uncertainty estimates have received relatively little attention from participants, but we retain hope that participants may eventually predict useful model uncertainties since users benefit from knowing the accuracy of a predicted value.