The pursuit of advancements in immuno-oncology by academic and commercial organizations has led to proliferative, sustained, and rampant expansion of journal and patent publications. In this report, leveraging the extensive CAS Content Collection™, we delved deep into this fast-growing corpus of scientific publications aiming to identify emerging trends that will be invaluable to researchers in this vibrant community. We utilized a novel natural language processing (NLP)-based algorithm in combination with extensive curation by subject matter experts resulting in quantitative identification of >300 emergent topics across eight main areas of interest. Moreover, our analysis allowed us to capture ideas that appear to be in the very early/nascent stages of emergence. We have designed a trend landscape map to illustrate the spread of emerging ideas in immuno-oncology across a wide range of topics with an emphasis on their growth over the last 3 years.