Amide bond formation is one of the most frequently used reactions in medicinal chemistry. The demand for greener approaches for amide bond formation has been growing over the last decade. Although amide bond formation via acid chloride or acid anhydride is particularly useful in the large-scale synthesis, this approach usually requires organic bases (e.g. Et3N: 101 g/mol) for trapping the generated acid. An alternative method, the Schotten-Baumann reaction 4 , uses environmentally friendly solvents (e.g. water) and inorganic bases (e.g. NaOH: 40 g/mol) which are less wasteful and inexpensive. Therefore, the Schotten-Baumann reaction has a high potential to achieve greener amide bond formation.