With both homologation reactions in hand, the power of the automated assembly-line was demonstrated by applying it to the synthesis of amide 11, which is a late-stage intermediate previously employed in the synthesis of the neurotoxin (+)-kalkitoxin (Fig. ). Remarkably, starting from boronic ester 9, six consecutive homologations were performed in a continuous sequence that was autonomously completed in 5 days and required only provision of fresh carbenoid precursors and n-BuLi at the start of each homologation (Fig. , Movie S1). Excellent conversion was observed at each step, as evaluated by offline GC-MS analysis of aliquots collected by the robot, and the final boronic ester 10 was formed in 46% NMR yield (88% yield/step) with complete reproducibility over two parallel runs. Moreover, the whole sequence was carried out with simple automated filtrations of the reaction mixture between the homologation steps, thus, the only chromatographic purification required was that used to purify boronic ester 10, which was isolated in 41% overall yield. Importantly, no supervision was required during the execution of the program, which enabled a non-synthesis expert to run the entire synthesis with minimal intervention. In order for fully automated syntheses of organic molecules to be achieved, it is important that a single robotic platform has the capability to perform diverse chemical reactions. Therefore, we subsequently investigated the conversion of boronic ester 10 into amide 11, which requires the transformation of the boronic ester moiety into a primary amine, followed by acylation and methylation (Fig. ). Upon optimisation (see Supplementary Materials), these steps could also be performed on the robotic platform in a fully automated sequence, which provided amide 11 in 48% overall yield after purification by column chromatography. Thus, benzylic boronic ester 9 was successfully transformed into the complex tertiary amide 11 in 20% yield over a sequence of 9 fully automated synthetic steps with only a single intermediate chromatographic purification.