The experimental results quantify the improvement in de novo molecule generation with humanin-the-loop interaction. Experiments with a simulated chemist show that less than 200 molecule evaluations are sufficient to significantly improve the average score of the generated molecules in both use-cases (Tasks 1 and 2), even with noisy feedback. Furthermore, a demonstration with a medicinal chemist's feedback supports this conclusion. We also provide a graphical userinterface where a chemist can interactively input their feedback.