Even though logP was one of the two criteria for defining the PhysChem window used here, is the top descriptor in all 3 SHAP analyses of the Descriptor model performed on the 3 data sets (training, time-split, and the external validation). All of these analyses show a common trend that higher logP values tend to have higher SHAP values and vice versa. Such relation can be interpreted such that with the higher logP values, the model favors the This relation between logP values and lysosomotropism can also be noticed in the violin plot of the original lysosomotropic class distribution versus the logP values (Fig. ). Here, across all the three datasets, the lysosomotropic compounds tend to have higher logP values compared to the non-lysosomotropic ones.