To determine the asymmetry in D4R occupation within a given topology, we must label the individual D4Rs. However, with the exception of UOV, all the D4Rs in each of the considered topologies are crystallographically equivalent. To solve this, for each snapshot, we assign a label to each D4R based on its relative occupation, from the least occupied to the most occupied. Then, the average occupation for each label is calculated over the entire trajectory (Figure ). This allows us to compare, for example, the average maximum and minimum occupations of symmetry equivalent D4Rs within a given topology.