Rank 3. Distance above 10 corresponds to either route where retrosynthesis analysis did not reach the state of available starting materials or has multiple major issues with the reaction feasibility. A typical example of rank 3 is shown in Figure (molecule 39, distance 12.1). In this case, our retrosynthesis tool has not solved the task to all available starting materials which is reflected by the bad score of the SDF model for all the predicted routes.