Nevertheless, the content of terpenoids in marine invertebrates is typically low, presenting a significant challenge for downstream drug development. To address this, chemical scientists have diligently explored synthetic routes to overcome this limitation, albeit with unsatisfactory yields . Recent studies have shifted focus to biosynthesisrelated investigations, aiming first to determine whether symbionts or marine animals are the primary producers of these terpenoids . This investigation led to a surprising discovery: corals and sponges contain active terpene synthases (TSs) in their genomes, enabling them to produce terpene scaffolds independently, debunking the previous theory that microbial or algal symbionts were primarily responsible . This finding substantiates that marine animals are indeed the true producers of these compounds.