Common subsets were also computed to enable full-panel bioactivity analysis of proteins without a true fully dense common subset. For example, for EGFR (P00533), a bioactivity analysis subset was derived from a common subset computed with a minimum variant threshold of three and a variant coverage of 10%. For HIV-1 RNaseH-RT (Q72574), from a common subset for variants with a compound coverage greater than 3%. For IDHC (O75874), from a common subset for compounds tested on at least two variants and variants with a compound coverage greater than 20%. Finally, for epigenetic regulator BRD4 (O60885), from a common subset for variants with a compound coverage greater than 2%.