To reveal the chemical space of BigSolDB, we prepared parametric t-SNE projections of BigSolDB and Tox21 dataset (reference dataset) on the same plot (Figure ). One should regard that the number of compounds in Tox21 dataset is larger than in BigSolDB. So, we had have to set a lower opacity value for Tox21 data points to prevent the visual suppression of BigSolDB 3/13 points. One can see that the overall distributions of chemical compounds are similar; both Tox21 and BigSolDB are broad and diverse. We highlighted and described several representative clusters on this map. The cluster (A) comprises "simple" aliphatic compounds. The cluster (C) is represented by aromatic compounds with the dominance of substituted benzenes. cluster (H) comprises of aliphatic heterocycles. The groups of steroids (F) and sugar derivatives (G) are well-recognisable. There are two clusters (D) and (E) which consists of two established clusters: N-phenyl-1-thia-3-azaspiro [5.5]undec-2-en-2-amine derivatives and Desethylenenorfloxacin derivatives. However, BigSolDB is notably enriched with sulfonamide derivatives (B) been compared with Tox21 dataset.