The biocompatible MOFs being susceptible to dissociation showed limited GUV formation, Zn-MOF-177 demonstrated minimal anchoring, CaBDC only anchored to GUVs formed with a negatively charged lipid mixture, yet GUVs remained bound for 6 hours. This feature is supportive for targeted therapeutic administration where short-term MOF-phospholipid interaction is required. Hence, this work shows the potential of MOFs as a versatile platform for biomaterials application in single liposome monitoring and assays, fluorescence-based data collection, and drug delivery.