Note regarding the nomenclature: In the context of the following description of the SAVI project, we employ a chemoinformatics usage of terms, which may differ from synthetic chemists' conventions. The (typically: named) chemistries used in SAVI are described by "transforms" (also called "rules"), whereas the application of a transform to a specific set of starting materials yields a "reaction." For example, there is one Sonogashira coupling transform/rule, but its application to all possible starting materials may yield tens of millions of Sonogashira reactions, each with a specific reaction product. The starting materials are taken from a set of possible reactants, which are also called building blocks (BB(s)). Some of the newly added named reactions were encoded in several different transforms expressing variants of reaction mechanisms, which we call "chemistries." For example, the Suzuki-Miyaura chemistry is encoded in six different transforms: Suzuki-Miyaura Cross-Coupling (Bromo), Suzuki-Miyaura Cross-Coupling (Iodo), etc. (see Table ).