All chemists felt that having CIME4R available influenced their decisions differently. Without CIME4R, they would have felt the need to either choose all experiments based on chemical intuition or solely run the experiments suggested by the EDBO algorithm. Comparing the next batch of experiments chosen by the chemists to those selected by EDBO, showed some differences in approach. While both the chemists and EDBO focused on exploiting the current best ligand (CgMe-PPh), only the chemists explored alternative ligands that had not yet been used in the optimization campaign.