To demonstrate the feasibility of this approach, we initially focused on identifying suitable catalysts. ACL was selected after screening eight enzymes, sourced from prior studies, against carboxylic acids of various chain lengths. The chemocatalyst for alcohol oxidation was chosen based on previous results. After confirming its compatibility with the enzymatic reaction conditions, we evaluated the potential to combine the two catalytic processes sequentially in a one-pot/two-steps procedure. This approach enabled the synthesis of five AMFCbased amides: four with aliphatic chains from C4 to C8, and one as a diamide product from succinic acid. This represents the first proof of concept and paves the way for developing a hybrid one-pot/one-step process. The results reported here serve as a foundation for further development in the synthesis of AMFCbased derivatives and the advancement of hybrid processes involving these two families of catalysts.