We further investigated possible preferred orientations of polymer moieties around CUR molecules by calculating distance histograms, combining data from all systems based on the respective polymer types (Figure ). Most histograms show very similar distributions, though some smaller differences are noticeable; as A-pPrOzi-A systems showed a generally higher drug loading within the core, PrOzi Additional occupancy density hotspots of polymer moieties were calculated for all CUR molecules of selected systems to complement these measurements (Figure ). In each case the most pronounced hotspot for the polymer carbonyl oxygen is found near the phenolic hydroxyl groups of the drug.