As an alternative to the original WG element, binominal multiple-pulse WATERGATE elements (e.g. W3/W5) could be integrated into the sequence. The binominal W5 element comprises a series of varying flip angle pulses with a fixed interpulse delay τ (see Supporting Information, Figure ). It accomplishes the same effect as the WG element, on-resonance signal experiencing a net 0° rotation. As in the original WG element, the suppression bandwidth is controlled by the duration, 4τ for W5. However the binominal sequence causes suppression not only on resonance but also at intervals of 1/τ Hz. This causes problems if a narrow suppression band is required, because the long interpulse delay τ leads to additional suppression notches within the spectrum of interest, potentially suppressing solute signals (see Supporting Information, Figures and). Although more complicated to set up if the best suppression is required, the selective pulse WG element is therefore preferable to the binominal W5 element (unless multiple suppression notches are required). The selective pulse WG element was used for Figures and.