Decision variables are independent inputs that can be controlled by the designer or operator. For both GAC and IX technologies, an initial decision is whether to use single-use or reactivated/regenerable options. Single-use GAC has significant environmental impacts due to its high media usage rate and the need for frequent replacement and disposal. This frequent replacement can lead to higher emissions of carcinogens and non-carcinogens, negatively affecting air quality and human health in surrounding communities. In contrast, reactivating GAC media reduces these impacts by decreasing the demand for new media production; thus lowering resource consumption and waste generation. Reactivation processes also mitigate negative health impacts by reducing the frequency of GAC media replacement; thereby lowering emissions. Although the initial costs for reactivation infrastructure can be high, reactivated GAC is more cost-effective and environmentally sustainable than single-use GAC. This is particularly true at higher contaminant concentrations because reactivated GAC has lower operational costs for media replacement and disposal. Similarly, the choice between single-use and regenerable IX also significantly affects sustainability. Both single use and regenerable IX have lower environmental impacts compared to single-use GAC, primarily due to their extended operational life and reduced media usage rate. However, the production phase of regenerable IX presents social risks, particularly high carcinogenic emissions, fossil fuel depletion, and global warming potential. These can lead to long-term health and environmental consequences. The type of sorbent used in GAC primarily affects environmental sustainability and financial viability. Media from different carbon sources have varying adsorption capacities and lifespans, which impact the frequency of replacement, resource consumption, and waste generation. Bituminous GAC is widely recognized in research as one of the most effective media for removing PFAS. However, there is still a lack of studies addressing its environmental sustainability and financial viability. Each decision variable can involve tradeoffs across overall sustainability of the PFAS treatment technologies. Therefore, a comprehensive evaluation is necessary to optimize treatment outcomes.