In this work, the peptides were functionalized at their carboxyl-terminus with short sequences whose biological activity is well established. GHK, KGHK and RDKVYR have been proven to be factors which accelerate wound healing . Peptide hybrids were designed to stimulate angiogenesis, attract immune and endothelial cells during injury and increase proliferation of fibroblasts while slowly releasing the signaling sequence. The triggering catalyst which releases the active sequence is human neutrophil elastase, which cuts the hybrid peptides within the AAPV site. It is worth emphasizing that neutrophilic elastase is present in wound, apart from MMP7 and MMP9, which are most prevalent in such locations, and, remarkably, it is upregulated in infected wound samples . Therefore, when designing the amino acid sequence of the studied peptides, we chose a sequence that is specific to this enzyme.