Tablet preparation and hyperthermia-induced drug amorphization. A DoE approach with a D-optimal design, resembling two, parallel central composite face (CCF; Figure )-centered fractional factorial designs, was used to study the effect of critical process parameters and their interactions on the Tmax and the degree of drug amorphization in the tablets. The experiment was set up using MODDE 12.1 (Umetrics AB, Sweden). The nanoparticle load was varied at 10, 15, and 20 wt% (with respect to the total tablet weight, Table ) and the celecoxib load at 30, 40, and 50 wt% (with respect to the polymer weight, Table ). Two SPIONs (Zn0.5Fe2.5O4 and Mn0.5Fe2.5O4) and the duration of AMF exposure (3 -15 min) were also included in the design. In total, 34 experiments were conducted (Table ), of which each CCF design had eight full factorial points, three center points and six star points. Models were fitted with multiple linear regression and adjusted by removing non-significant model terms. A value of p < 0.05 was considered significant. The surface contour plot was constructed to visualize the effect of the factors on tablet temperature and drug amorphization.