High-performant ab initio methods have been employed to determine the interactions and correlations between amino acids and their side chains such as CCSD-F12, CCSD(T)-F12, MP2-F12, SAPT, etc. with a relatively good level of accuracy . The significance of studying the quantum correlation energy of amino acids lies in its ability to provide chemical insight into the energy landscapes in which proteins exist and the mechanisms underlying their stabilization and to some extent, their folding process. These insights arise from quantum chemical correlations between the substituent electronic degrees of freedom. These correlations can be quantified either from an energetic or an information theoretic perspective.