The Supporting Information is available free of charge on the ACS Publications website. Materials and instruments, production and characterization of DC-SIGN ECD and CRD, chemical synthesis and characterization, ECD and CRD N-terminal labelling with LA-EG11-TzTFP or LA-EG11-TFP, preparation and modification of 13 nm diameter gold nanoparticle (G13), GNP-CRD characterization, pseudo-SARS CoV-2 virus preparation and inhibition studies, inhibition of authentic SARS-CoV-2 infection by G13-CRD, estimation of interspike distance on virion surface (PDF)