variecolor , while compounds 65-67 were reported from A. nidulans . Compounds 59-60 exhibited potent DPPH radical scavenging activity (antioxidant activity) with IC50 values of 6 and 11 μM, respectively suggesting that the O-methylation of eurotinone, (59) slightly affected its antioxidant activity. Questinol which was also isolated from the marinederived fungi Talaromyces stipitatus KUFA 0207 and Eu. amstelodami , displayed significant anti-inflammatory activity via different mechanisms including inhibition of both nitric oxide (NO) and prostaglandin E2 (PGE2) production and, inhibition of the production of some inflammatory cytokines such as interleukin-1β (IL-1β), IL-6, and tumor necrosis factorα (TNF-α). Compound 62 also showed slight inhibitory activity against cyclooxygenase 2 (COX-2) expression at a concentration of 200 μM . In addition, 62 exhibited potent antiobesity activity with a 60% reduction in the stained lipids with an IC50 value of 0.95 μM, while the chemically related compound, fallacinol showed no significant anti-obesity activity .