We processed all FTIR and UV-Vis spectra using custom MATLAB scripts written in-house (see SI). We performed baseline correction and background subtraction for all spectra. To compare the spectra, we additionally normalized FTIR spectra to the total integrated intensity. We used Prism Graph-Pad software to fit the kinetics and binding affinity data collected with UV-Vis spectroscopy. Multivariate curve resolution (MCR) analysis was performed using the MCR-ALS software developed by Felten et al.