Advancements in non-enzymatic glucose sensing have been achieved through the use of nanomaterials in electrochemical processes, providing a solution to the limitations of enzymebased glucose detection. Non-enzymatic sensors usually have greater sensitivity than enzymebased sensors and are considered the next generation of glucose meters. To improve the performance of non-enzymatic sensors, one can alter the topological structure of materials to increase specific surface area and electrochemically active sites, and form hybrids by combining or doping with other materials. The working electrodes in non-enzyme sensors are constructed using metals and their compounds, such as metal-organic frameworks (MOFs), conductive polymers, inorganic carbon materials, and other nanomaterials. The composite of two or more materials maximizes the respective advantages of each material, resulting in better non-enzyme sensor performance, including higher sensitivity, a wider linear range, and a lower detection limit. For instance, platinum nanoparticles are commonly used in non-enzymatic glucose sensors. In addition, non-noble metals, such as Cu, Mn, Fe, and Ni, as well as metal sulfides and oxides, have been widely investigated for non-enzymatic electro-oxidation of glucose, as noble metals are generally expensive. The unique physicochemical properties of 2D nanomaterials such as graphene make them a promising class of materials for sensing devices. Their high surface-area-tovolume ratio also makes them suitable for application in Internet of Things platform, providing exceptional sensitivity to target glucose molecules. Additionally, sensors based on 2D materials can be miniaturized due to their high mechanical strength, flexibility, and optical transparency. Among all, graphene is one of the most promising for highly sensitive detections of glucose.