The BSA corona on SNPs-30 likely also reduces their adhesion energy with the membrane as membrane wrapping and vesicle collapse is no longer observed. This is despite the larger size and hence lower curvature of these NPs, which would reduce the energetic cost of membrane wrapping. This is in contrast to the SNPs-18@BSA particles, where the adhesion energy was still sufficient to promote membrane wrapping and shrinkage of GUVs. Therefore, we conclude that the curvature of the SNPs influences the assembly and structure of the BSA corona, giving different effects on the modulation of the NP adhesion energy. The weakening effect of protein coronas on the interaction of SNPs with lipid vesicles and cellular uptake has been reported before 14-16 . NPs of different chemical compositions, such as gold and polystyrene, have also exhibited reduced membrane activity and cellular uptake when coated with protein coronas . However the magnitude of the effect of the BSA corona may subtly depend on the surface properties of the NP onto which they absorb, which influences the structure and assembly of this protein coat.