In terms of potency against Ca 2+ /CaM-stimulated AC8 activity, the halogenated series was generally least selective at around 50% AC8 inhibition at the AC1 IC90 with the exception of the 3-Br derivative at 15% AC8 inhibition. When the substitution was switched to lipophilic alkyl functionalities there was an observed drop in AC8 inhibition at the AC1 IC90 for the analogs tested.