The nature of the solvent has a major influence on reaction kinetics and product yield in the oxidation reactions. Also due to the environmental and sustainable requirements, it is important to choose a suitable, green, and sustainable solvent that offers high reaction efficiency, and an easy industrial process. Therefore, we selected a series of solvents and explored the effect of different solvents on the oxidation of benzoin. As shown in Figure , we found that the solvents had a significant influence on benzoin yields, especially at the beginning of the reaction. 18.2%, 28.8%, 43.6%, and 45.5% of benzil yield were obtained using Tween, MIBK, n-BuOH, and ACN as solvents respectively. Surprisingly, when tBuOH was used as the solvent, K2CO3 exhibited the highest catalytic activity and the yield of benzoin was 84.4%. Interestingly, after 6 hours, both n-BuOH and t-BuOH could give a similar excellent yield of 93% while the other solvents only showed less than 80% yield. A similar trend was also observed in the Ti and Sn catalytic oxidation systems (Supporting information Figure ). Other solvents like DMSO, EtOAc, THF, DMC, DCM, DEC, Heptane, and Cyclohexene were also evaluated. While the Heptane, DMSO, and DCM gave an excellent yield of benzoin (Supporting information Figure ). Even if the reaction temperature drops to 40°C, a 98% yield of benzoin could still be obtained for the Ti system (Supporting information Since benzoin is not soluble in H2O, then we evaluated the H2O as a co-solvent with t-BuOH in the K2CO3 catalytic oxidation of benzoin. As shown in Figure , the H2O had a significant effect on the reaction. When the ratio of tBuOH/H2O decreased from 4/1 to 3/1, 1/1, the benzoin yield decreased gradually. A similar trend was obtained when using DMSO and H2O as the co-solvent. It was also found that the AC had a great effect on the reaction. When the reaction was carried out without AC, the reaction gave a lower benzil yield of 73.7% compared with the reaction with an AC of 90.0% yield after 5 hours.