However, one shortcoming of RMD is that it is time-consuming due to the necessity of detailed resolution of molecular dynamics such as bond vibrations. One solution is to accelerate the dynamics of the system to observe slow reactions in a reasonable simulation time frame. Various acceleration techniques have been proposed with ChemTraYzer-TAD (CTY-TAD) and PESmapping being two most recently developed acceleration methods for reaction discovery. They both employ RMD and have been used for reaction exploration of biofuel combustion . CTY-TAD is designed as an extension of the well-known TAD 52 method, which simulates chemical systems at high temperatures to take advantage of faster dynamics and introduces reflecting walls whenever a reaction is detected during the simulation. CTY-TAD extends TAD with an improved reaction detection by ChemTraYzer (CTY), hence the name. Once a reaction has taken place, the system is reset to its initial state, and the reflecting walls ensure that no reaction path is simulated more than once. Unlike the original TAD, the system is not advanced into the next basin. On the other hand, PESmapping is based on the hyperdynamics acceleration technique and utilizes history-dependent repulsive Gaussians to drive the system along pre-defined collective variables specifically tailored for combustion systems, distributing these variables over an extensive set of short RMD trajectories. Both techniques are specially designed to explore a chemical space to detect reactions in a combustion system.