The posting of preprints in chemistry has steadily grown over the past five years -see Figure for annual numbers of posted preprints on ChemRxiv. There were also noticeable boosts in the reading of preprints during the early phases of the COVID pandemic, when many labs were shut down and researchers in all fields were interested in uncovering new data that could later lead to important treatments and vaccines (see Figure ). Consumption of ChemRxiv content has slowed slightly after reaching a high, resulting from some highly-read COVID preprints, and the number of preprints posted in 2022 is on pace for almost a 10% increase over 2021. When considering how the posted preprints fit into the larger publishing ecosystem, we have found that more than half of the nearly 14,000 preprints on ChemRxiv have already been published in peer-reviewed journals, and this number continues to grow. The final publication destinations for ChemRxiv authors include the full range of top journals in chemistry, such as titles published by all our partner societies, and even multidisciplinary journals like Nature and Science.