CD28 is a protein receptor on the surface of T cells and is vital in helping them fully function and remain active . It does so by interacting with markers on other immune cells to boost the immune system response, allowing the body to defend against infections . CD28 has become a hot topic in autoimmune disease treatment and preventing rejection in organ transplants . TYRP1 (Tyrosinase-Related Protein 1) is a protein that is vital in producing melanin, the natural pigment of the hair, eyes, and skin . The protein aids the process of melanin creation by being active in melanocytes, which are the cells responsible for pigment production . Defects in the TYRP1 protein can result in pigment-related disorders like albinism, where affected individuals have little to no pigment . This makes them more prone to harmful skin conditions with an increased sensitivity to sunlight. A high level of TYRP1 expression has been associated with melanoma progression . In addition, these receptors also play a crucial role in tumor growth and progression . Finally, these receptors have the potential to escape immune surveillance, thus making cancer cells more resistant to immune system attacks . Since the receptor is essential in melanoma, it could be a potential focus for melanoma-targeted therapies.