Before building the QSAR model for Fa, we analyzed the chemical space of the prepared dataset to check its bias using the 5NN of the Tanimoto similarity. The results of this analysis are shown in Figure . The average 5NN Tanimoto similarity in the dataset collected in this study was 0.352, which was lower than that of FDA-approved drugs (0.429). The p-value of the average of 5NN Tanimoto similarity between the compounds collected and FDA-approved drugs was 2.11