Reactivity: Filter kraken ligands using a V bur (min) threshold Selectivity: Virtually screen remaining ligands using an ensemble of linear models Heterocycles, such as furan (leading to product 3af) and thiophene (product 3ag) were tolerated with yields up to 91 and 92%, respectively. Interestingly, a pronounced selectivity drop with the furanyl pinacol boronate was only observed using conditions C2 (3af, 53:47 E/Z compared to 84:16 Z/E with C1).