The baselines used in our experiments include: i) four templatebased methods, i.e., Retrosim , Neuralsym , GLN and LocalRetro ; ii) six template-free methods, i.e., SCROP , Chemformer , G2S , GTA , AT and Retroformer , and iii) five semi-template methods, i.e., RetroXpert , G2Gs , GraphRetro , MEGAN , and Retro-Prime . We test each method in two scenarios with known and unknown reaction types, respectively. In each scenario, we record the top-1 and 3 match accuracy of reactant prediction.