Although equation (1) accounts for the solvent displaced by the solute in the scattering signal calculation, it does not consider the contribution of the solvation layer. This layer depends on solvent-solute interactions and is typically more electron-dense than the bulk solvent, e.g., it has been reported to be up to 20 -25% more electron-dense than bulk water . This phenomenon can result in an increase in the solute's apparent radius of gyration . The contribution of the solvation layer can be included in calculations through explicit solvent modelling, as implemented in software such as WAXSiS positions of the solvent atoms in the hydration shell while calculating the scattering signal of the molecule in solution. However, this approach is computationally expensive due to the large number of solvent atoms that must be considered in addition to those of the molecule, furthermore it may still be approximated because of the limitations of force-field inaccuracies in water-water and water-solute interactions . Implicit solvent modelling methods, on the other hand, allow the calculation of the solvation layer contribution to the scattering signal without the need to model the solvent atoms explicitly, thus reducing computational cost, but with approximations in the description of the layer . In general, this is obtained including a solvation layer term in equation ( ):