In this study, we computationally investigate MOF activation-collapse to assess the empirical 85 guidelines developed to prevent collapse and generate algorithms for a priori prediction of collapse (or lack thereof) during activation. Treating solvent activation as a fluid desorption problem, we apply commonly used grand canonical Monte Carlo (GCMC) techniques to investigate this process. We take advantage of transition matrix Monte Carlo (TMMC) simulation algorithms to evenly sample the entire potential energy landscape for the activation of each specific MOF-solvent pair. TMMC is a 90 technique widely used to model phase coexistence behaviour of both bulk and confined fluids, and has been applied to simulate methane in MOFs at subcritical temperatures and to screen different process conditions. However, to the best of our knowledge this is the first time that phase behaviour of confined organic solvents is studied using TMMC.