molecules. The degree of this binding is also influenced by the drug's general lipophilicity. When compared to acidic molecules, basic molecules often leave the systemic circulation with a greater volume distribution (Vd). Compared to neutral or basic compounds, acidic molecules have a stronger affinity for albumin molecules at lower lipophilicity. As a result, compared to more basic molecules, acidic drugs are more likely to bind albumin and stay in the plasma, resulting in a reduced volume distribution (Vd) (Asad and Navid, 2021) .