In order to explore in more detail and compare criteria for the reproduction of multimolecular entities, it is useful to probe similar processes in nowadays cells. Cellular reproduction is a process by which cells duplicate their contents upon growth, followed by fission to produce faithful progeny. Reproduction is enabled by the balanced exponential growth of all cellular components at the same growth rate . This is concomitant with maintaining the proteome and transcriptome largely unchanged during cellular proliferation . Specifically, small positive changes of mass occur due to a slight excess of compound uptake, while at consecutive time points steady-state concentrations of the components are preserved. This process is referred to as homeostatic growth , also described as balanced growth of intracellular chemicals between cell birth and division, a hallmark of ensemble reproduction . Thus, a likely sufficient condition for assembly reproduction is homeostatic growth of the dynamic chemical network, driven by catalyzed molecular uptake and synthesis. GARD's dynamic simulations, based on explicit definitions of volume, concentrations and catalytic rate constants, afford a rigorous test for the reproduction of molecular assemblies via the homeostatic growth criterion. Many models for life's origin deal separately with the reproduction of small molecule networks, templating polynucleotides and self-copying vesicular lipid containers . In contrast, GARD has the infrastructure to address the necessary synchronous reproduction of all endogenous components, including lipids, as prescribed .