Fexofenadine was predicted to have good M pro activity by Autodock Vina and to be a moderate binder by Autodock . Astemizole was also predicted to bind well to the SARS-CoV-2 spike protein by the PLANTS algorithm. It was in the top 2% of molecules that were rescored using MD (Amber and the Nwat-MMGBSA method) . It was also predicted to bind to the viral RdRp with high affinity using Autodock Vina . Our earlier studies predicted sertindole to be a strong binder to SARS-CoV-2 RdRp 6, 7 , and the activity of sertindole against M pro also was later reported by Vatensever et al. .