The similarity of bulk nanobubbles and microemulsions leads us to propose a compressed amphiphilic monolayer model for bulk nanobubble stability. In this mechanism, we assume that some stable bulk nanobubbles comes from the shrinking of large bubbles, e.g., micro-bubbles. The initial formation of microbubbles can be induced by either swelling of micelles at large gas supersaturation or by macro-bubble collapsing. Then, at low gas supersaturation the gas dissolution causes the shrinkage of the microbubbles until the formation of the compressed amphiphile monolayer at the bubble interface, which would lead to the formation of stable bulk nanobubbles (see Figure ).