We used the CHARMM-GUI web server to model a 200 Å nanovehicle and estimate its drug payload capacity, Figure . Our findings show that 20 protamine molecules, each associated with an ATP-aptamer, may fit inside a single nanovehicle of this size. However, due to AlphaFold by making reasonable chemical mutations that depend on the important base pairs involved in the protein binding. Moreover, delivering the aptamers to the targeted cell is difficult. It's also challenging to make sure aptamers can interact with the intracellular target through the plasma membrane. A promising approach to overcome all these challenges is using aptamer-conjugated nanomaterials with target-specific binding capacity. Some common nanomaterials are nanoparticles, nanoconjugates, and nanorods. These exhibit unique properties like small size, large surface area, and the capacity to get beyond biological barriers (21) .