Nitschke and co-workers reported the iteroselective functionalization of tris-anilines via a dynamic subcomponent self-assembly process (Figure ). Several supramolecular structures can arise from the reported self-assembly including one kinetically metastable intermediate formed by the condensation of two of the three amine functions with an aldehyde to form imines stabilized by coordination to iron(II). The remaining unreacted amine of the kinetically trapped iteroselectively diprotected tris-anilines is then functionalized prior to disassembling the supramolecular structures. This process is a clear example of kinetically controlled iteroselective reaction. It is important to note that the functionalization of the last free amine does not constitute the iteroselective reaction but rather the initial condensation of two amines with aldehydes. Indeed, in protection / functionalization / deprotection sequences, the substrate that bears several identical functions that can undergo an iterative transformation is the initial substrate before protection. The following functionalization reaction is merely a per-functionalization of the remaining reactive sites, thus not showing any iteroselectivity. This difference is crucial to not confuse a seemingly apparent overall iteroselective reaction and the true iteroselective protection step. For the bis-condensation of tris(4aminophenyl)amine with two equivalents of 2-formylpyridine, the ite calculated is 93% from rnormal and rexp of 26% and 95%, respectively.