We then show that these concepts generalize further along the drug discovery process to hit expansion itself. To establish structure-activity relationships (SAR) of the hit matter, structurally related compounds are assayed. We show that straightforward selections can be made (deterministically or stochastically) using the EVP framework. Finally, we show that EVPs can be used to reveal SAR information in a target-specific context. EVP statistics are used to easily explore SAR providing useful considerations for hit expansion or hit-to-lead optimization.