Over the past few years, we have reported several synthetic approaches for the defluorosilylation and defluoroborylation of HFCs and HFOs. This includes the defluorosilylation of industrially relevant HCF3 (HFC-23) and 2,3,3,3-tetrafluoropropene (HFO-1234yf) under batch conditions using lithium silanide reagents. In the case of HFC-23, the reaction proceeds efficiently over 10 minutes at 25 °C, provided a low concentration of 1•PMDETA (20 mM) and excess of HCF3 (approx. 7 equiv.) is used. In the case of HFO-1234yf, cryogenic temperatures of -78 °C and a reaction time of 3 h are required. Both reactions could be performed on a 1 -3 mmol scale, allowing isolation of products in 68 -69 % yield (Figure ). In this paper, we describe a continuous flow method for defluorosilylation of both HFC-23 and HFO-1234yf. The approach allows facile scale-up. Optimal process conditions result in improved production rates and reduced solvent use compared to batch conditions, while also obviating the need for cryogenic temperatures. The new enabling technology provides access to small chain fluorinated building blocks in sufficient quantities to effectively explore their onward chemistry. We demonstrate a broad scope of difluoromethylation and trifluoroallylation of carbonyls, along with the discovery of a method to generate 3,3-difluoroprop-1-yne fragments from HFO-1234yf.