Sonosensitizers are compounds that preferentially accumulate in tumor tissues. When exposed to ultrasound, these sensitizers undergo a physical or chemical transformation, leading to the production of ROS, such as singlet oxygen (1O2), hydroxyl radicals (•OH), and superoxide anions (O2•-). The application of low-intensity ultrasound to the tumor site activates the sonosensitizers, leading to the localized generation of ROS within the tumor microenvironment. The resulting oxidative stress can cause direct damage to tumor cells, leading to cell death.