The ADV blind-docking results of the DWBEL fitted-children, predicted highest ~ 3 -4 nM (n=2) affinities to top-children conformers derived from 24L (Figure , red circles, and black-edged red circles). The 24L was one of the star ligands cross-docking CSP N and C-terminal α-helices (Figure , red). Similar but lower affinities of ~10-50 nM affinities were predicted from 28L and 23L derivatives (Figure , red squares and triangles). Much lower ~ 100 nM affinities were predicted from 25L and 30L derivatives (Figure , cyan circles and orange circles) or ~ 1000 nM affinities from 20L and 21L derivatives (Figure , cyan squares and orange squares). Therefore, 24C, 28C and 23C were the main targeted CSP cavities, corresponding to the N-and C-terminal domains (24C) or to C-terminal domains (28C, 23C). In contrast to the local targeting of DWBEL, the full-length ADV blind-docking may generate additional conformers that may target different cavities. Therefore, confirmation of ADV-targeting cavities were then performed for each ADV conformer.