As demonstrated in the task of method search and information extraction from literature, Literature Scouter demonstrated its capability to assist researchers to identify the possible methodologies necessary to achieve the target transformation under desired conditions, and extracting the required experimental details for executing the reaction. Compared to conventional workflow for identifying the proper chemistry from literature database, Literature Scouter alleviated the laborintensive tasks of literature searching and reviewing, thus significantly expedited the process and lowered the expertise requirement. Especially, when Literature Scouter was connected to an up-to-date academic journal database, it could propose the new chemistries that were not included in the LLM model pre-training process (Supplementary Information Section 2.1-2.2).