Lastly, we discussed the similar and dissimilar protein-protein binding poses of eight pairs of ternary complexes available in the literature. We suggested that non-perturbative ligands might already exist to stabilize the intrinsic PPIs, which coincides with the design protocol of interface-targeting molecular glues. We anticipate that our work will provide new insights into understanding the cooperative process in ternary complexes and facilitate future design in cooperative PPI stabilizers.