Non-steroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen, diclofenac, or nimesulide are commonly consumed pharmaceuticals. Their widespread use has led to increasing environmental concerns, primarily because many of these drugs are excreted unmetabolised entering wastewater treatment systems. Their effective removal is challenging while posing potential ecological and health hazards due to their persistence and bioactive properties, even at low concentrations. Compared to other NSAIDs, nimesulide is known to have potentially toxic effects on aquatic organisms, influencing their development and reproductive health . This emerging contaminant threatens water ecosystems by disrupting microbial communities, promoting antibiotic resistance, and negatively impacting aquatic organisms .