Drug repurposing. The current work proposes an innovative virtual high-throughput screening to predict the activity of 10,672 compounds for 25 targets. After applying the best classification model, we ranked drugs per target and multi-targets taking into account several criteria: first ATC levels associated with COVID-19 symptoms, pharmacological indications, and the best AUROC values. Consequently, on one hand, we obtained 45 approved drugs, 16 compounds under investigation, and 35 experimental compounds with the highest affinities for 15 immune system proteins (Supplementary Table ). On the other hand, we obtained 4 approved drugs, 9 compounds under investigation, and 16 experimental compounds with the highest multi-target affinities for 9 immune system proteins (Supplementary Table ).