Following a reported procedure, 9 trimethylsilyl triflate (1.0 mL, 5.5 mmol, 1.1 equiv) was added to a suspension of BIOH ( ) (1.3 g, 5.0 mmol, 1.0 equiv) in CH2Cl2 (15 mL) at RT The resulting suspension was stirred for 1 h, followed by the dropwise addition of trimethyl((4-(trifluoromethyl)phenyl)ethynyl)silane (18) (1.3 mL, 5.5 mmol, 1.1 equiv), which was dissolved in CH2Cl2 (1 mL). The resulting suspension was stirred for 6 h at RT. A saturated solution of NaHCO3 (20 mL) was then added and the mixture was stirred vigorously for 30 min, the two layers were separated and the organic layer was washed with sat. NaHCO3 (20 mL), dried over MgSO4, filtered and evaporated under reduced pressure. The resulting solid was boiled in CH3CN (20 mL). The mixture was cooled down, filtered and dried under high vacuum to afford 2c (1.12 g, 2.69 mmol, 54% yield) as a pale yellow solid. Following a reported procedure, 10 Trimethylsilyl triflate (1.0 mL, 5.5 mmol, 1.1 equiv) was added to a suspension of BIOH ( ) (1.32 g, 5.00 mmol, 1.0 equiv) in CH2Cl2 (15 mL) at RT. The resulting suspension was stirred for 1 h, followed by the dropwise addition of ((4-Chlorophenyl)ethynyl)trimethylsilane (0.68 mL, 5.00 mmol, 1.0 equiv), which was dissolved in CH2Cl2 (5 mL). The resulting suspension was stirred for 6 h at RT. A saturated solution of NaHCO3 (20 mL) was then added and the mixture was stirred vigorously for 30 minutes, the two layers were separated. The mixture was extracted with H2O and DCM (3x20 mL), washed with brine, then dried over Na2SO4 filtered and evaporated under reduced pressure. The resulting solid was recrystalized in EtOAc:MeOH (2:1) (40 mL/gram). The solution was left to cool to RT overnight. The crystal formed was filtered and dried under high vacuum to afford (2d) as a white solid (658 mg, 1.72 mmol, 34%). . Consistent with reported data. 10