The addition of Toxicity Risk during the DW-BEL co-evolution was suggested by detection of ~ 50 % toxicities on the predicted children, during our previous work targeting Vkorc1, FtsZ, LolCE and omicron S . Since the inclusion of Toxicity Risk could theoretically increase the percentage of non-toxic children and/or improve the penetration into unexplored chemical spaces, it was suggested to the DW researcher forum. A previously developed DW toxicity assessment code was then kindly included by Dr.T. Sander as a new DW-BEL Toxicity Risk criteria with its values and weights. To comparatively explore coevolution with DW-BEL ± Toxicity Risk, nine protein / ligand crystallographic pairs were selected here because of their practical importance.