The proposed "dual modeling approach", detailed in this manuscript, combines the development of a PAT strategy and reaction optimization in one synergistic workflow. This highly digitalized workflow is separated into two parts, which are simultaneously executed on one platform (Figure 1, bottom). The platform can be comprised of any flow chemistry equipment and different process analytics. A degree of automation is necessary to at least send new setpoints to the flow equipment over pre-determined time intervals. To follow this precise workflow, two valves should be present in the setup, allowing the reactor to be bypassed, dosing the product to the reaction stream before or after the reactor. This allows for maximum flexibility in terms of quick PAT calibration and investigation of the reaction design space.