The recent re-parametrization of the Martini force field (FF, version 3.0.0 4 ) improved the overall balance of non-bonded interactions between beads, as well as the accuracy of the scheme in predicting molecular packing in MD simulations. Notably, enhanced CG representation of molecular volumes can be obtained via the use of higher-resolution particles (small and tiny bead sizes). Particular attention was paid to the description of aliphatic and aromatic ring-like structures, which are ubiquitous in small molecules (e.g. solvents, drugs) and building blocks constituting macromolecules (e.g. proteins, synthetic polymers). Such improvements enable the modeling of increasingly complex systems comprising multiple classes of molecules, such as solvent mixtures, small molecules, polymers, lipid membranes, proteins and proteinligand systems; all within the framework of a general force field .