In addition to directly sensing viruses, AIEgens have also been applied in the detection of viral proteins. Viral antigen-based detection could be developed as a complementary screening strategy for early diagnosis of SARS-CoV-2 infection. SARS-CoV-2 consists of four structural proteins, known as spike (S), envelope (E), membrane (M), and nucleocapsid (N) proteins . Among them, N protein has been identified as one of the best early diagnostic targets and could be detected before the appearance of antibody in serum . Furthermore, the receptor binding domain (RBD) of S protein could be directly tested without virus lysis, which could act as a suitable diagnostic epitope . Recently, Zhang et al. developed a wearable lateral flow test strip based on AIEgens for rapid detection of SARS-CoV-2 RBD protein and N protein (Fig. ) . Compared with the antigen test based on colloidal gold or fluorescein isothiocyanate (FITC), this testing platform provides higher sensitivity and specificity, stronger anti-inference ability, and desirable reproductivity with simple preparations. As shown in Fig. , the N-hydroxysuccinimide (NHS) activated AIEgen reacts with antibody to produce AIEgens-labeled antibody. The test strip was composed of a PVC backing card, sample pad, nitrocellulose (NC) membrane, and absorption pad (Fig. ). The working mechanism of the strip was also shown in Fig. . In general, for the detection antibody without binding reaction with the target antigen, it passed through the T line and bound to the secondary antibody on the control (C) line, bright fluorescent signal could be easily observed under 365 nm UV light irradiation with naked eyes. Due to the high brightness and anti-bleaching ability in aqueous solution, the detection limit can be as low as 6.9 ng/mL for RBD protein and 7.2 ng/mL for N protein, respectively. Therefore, this AIEgen-based strip presented excellent testing performance and thus could be built as a promising platform for rapid and accurate virus detection during the pandemic. [62] with permission of American Chemical Society, © 2018.