The 3D structure in SDF format of 1064 phytochemicals were downloaded from pubchem and prepared using Ligprep module of Schrodinger suite which automatically generates enantiomers and tautomer of molecules. Further it performs protonation of molecules at pH 7.4, using Epik module . The potential binding efficacy of these phytochemicals to their respective targets were screened firstly via glide HTVS docking protocol (high throughput virtual screening). After this, top 100 molecules were selected and subjected to glide SP (standard protocol) in-silico docking method. This was followed by docking of top 20 phytochemicals using Glide XP (extra precision) module, which provides accurate binding efficacy . Further, 3D structure of proteins and 2D structures of drugs and there 2D interactions were prepared using respective module of Schrodinger.