The spike subunits called S1 and S2 are responsible for binding with the host-cell receptor and membrane fusion, respectively . Different variants have been detected but do not significantly influence the efficacy of the developed vaccines . In other concise words, SARS-CoV-2 is an RNA virus branded by crown-like spikes on the external surface . Any SARS-CoV-2 virus infection and replication cycle step is a potential target for antiviral interference. The binding of the viral spike protein of SARS-CoV-2 to the human cell surface receptor ACE2 is a critical step during the entry into human cells, causing infection. Hence, cell entry inhibitors could be used to prevent the SARS-CoV-2 virus and reduce the progression of COVID-19 diseases by preventing virus particles from infecting human cells.