In addition to the promising DNMT enzymatic inhibition profile of compounds 12 and 13, it is remarkable the reported high inhibition of both molecules of the epigenetic target G9a (IC 50 = 6, and 4 nM, respectively, Figure ). As discussed in the Introduction, based on the structural relationship between the quinazolines tested in this work with the 4-aminoquinolines reported as dual inhibitors of G9a and DNMT1, we hypothesized that quinazolines such as 12 and 13, could inhibit DNMT1.