Typical R0 value of a U.S. state is found to be at ~3. Then Rt is manually adjusted in a short period of choice to minimize the residual or directly calculated from the daily cases in a state. An example is shown with the data in the state of Ohio (Figure ) assuming no vaccination is taken for the SIR model. Both the Rt and Re values are found to be oscillating around 1 along the waves of outbreak. Students were instructed to continue their calculated daily cases well past 1/25/2022 that are not available when they did the analysis using the average reproduction numbers for the last 5 days of available data to predict the trend for the following months. The models overlap well with the data obtained later giving the students some predictive power (Figure ).