Analogously, we prepared BODIPY-NOD-4 and BODIPY-NOD-5 to study the effect of boron methylation (Scheme 1C). Compounds 2b and 3 reacted with freshly prepared MeMgI, giving products 4 and 5, respectively. After that, obtained compounds were nitrosated, using sodium nitrite and CH2Cl2/THF/AcOH mixture, to get final N-nitroso compounds BODIPY-NOD-4 and BODIPY-NOD-5. When working with iodinated and/or boron methylated compounds, we had to use milder conditions, due to the tendency of starting and target compounds to decompose under heating.