Top-scoring molecules will be further analyzed by a panel of experienced medicinal chemists in order to provide additional annotation to the molecules, including opinion on the suitability of the hits to serve as a starting point for potential drug discovery programs. Their reflections will not influence the score, but rather will help contextualize the output. SHARING THE CACHE OUTPUT CACHE will generate three main outputs for the community: screening data, chemical structures, and the performance of algorithms. CACHE's mandate is making available the screening data and the chemical structures to the community without intellectual property or other restrictions on use, and in a digitally readable format. These data will also include the composition of the virtual libraries screened, all predicted small molecules including negative data, and all screening methods.