Within these different approaches to ArM design, several scaffolds have been repeatedly used with various attachment strategies for transformation into novel catalysts. These scaffolds have been described as 'privileged' scaffolds, in a manner analogous with privileged ligands in homogeneous catalysis. The most prominent examples are the LmrR scaffold, which allows supramolecular, bioconjugation, and incorporation of unnatural amino acids 21 , and Sav, which has been explored in dative coordination , alongside the more common supramolecular approach . Despite these advances, few comparative studies have been conducted which included direct comparisons of the modification strategy for site-selective metal coordination. This makes it difficult to discern the role of protein modification upon ArM reactivity and predict the most effective route to ArM assembly for a desired application.