Generally, in bilayer simulations involving helper lipids and different combinations of head/linker and tail compositions from ILs, it is expected that neutral species will accumulate in the middle, forming an oil lens between the two leaflets and leading to a significant increase in membrane thickness. To demonstrate that our model can also capture this effect, we performed Martini simulations of DLMC3 and DLKC2 (DUM3 / DUMP and DUK2 / DUKP) when mixed with POPC (10:90, 20:80, and 30:70 IL:POPC mol%). CHARMM36 atomistic simulations were performed of bilayers at the same concentrations of ILs for comparison. These analyses were performed in either the fully charged or neutral state, representing low-and high-pH situations, respectively.