We previously discovered that decreasing Ru loading on CeO2 to a threshold triggers an increase in the disorder in the Ru structure, which coincides with drastic increases in the activity, selectivity, and isomerization ability in polyolefin hydrogenolysis. This discovery motivated us to examine how the support regulates the properties and thus performance of highly dispersed Ru species. Therefore, we impregnated low-loading Ru (0.07 Ru/nm 2 ) onto various supposedly nonacidic supports (see Table for BET surface area), and tested them in the hydrogenolysis of PP and LDPE (260 ℃, 30 bar H2). Results are summarized in Figure , with the best catalyst studied from previous works, Ru/CeO2, as a reference point. Surprisingly, an anatase TiO2 synthesized by a sol-gel method (referred to as "TiO2-A-SG", XRD see Figure ) clearly stands out with PP as the substrate (Figure ), showing by far the best per-Ru conversion rate (~350 gPP gRu -1 h - 1 , patterned bar, 3 times as high as Ru/CeO2), selectivity (< 5% CH4, green, ~80% liquid products, purple), and isomerization ability (> 60% isomers, orange). Nevertheless, its activity and selectivity with LDPE as the substrate is mediocre (Figure ), except for the high fraction of branched products (red). Meanwhile, among other supports, the performance of low-loading Ru is highly support-dependent with both PP and LDPE, and particularly, they surprisingly exhibit negligible activity on two supports, commercial anatase TiO2, ("TiO2-A-comm"), and carbon. This manuscript will only present detailed studies to understand the unique, intriguing performance of the TiO2-A-SG support. The strong support-dependence among other catalysts was hypothesized to be due to different morphology of highly dispersed Ru species, which we will report in a separated manuscript. ).