We computed all pairwise fingerprint-based and epigenetic activity profile similarities for the 187 Epi Food Chemical Database compounds. In both cases, we used the Jaccard-Tanimoto coefficient. The fingerprintbased similarity was calculated with four different fingerprints: ECFP4, ECFP6, MACCS Keys, and RDKit fingerprints. In total, 17,590 pairwise comparisons were computed for each fingerprint (including selfcomparisons) and 17,430 pairwise comparisons for each fingerprint (excluding self-comparisons). The structure vs. epigenetic activity profile similarity was plotted in a scatter plot reminiscent of the structureactivity similarity (SAS) maps. Figure shows a prototype plot of a SAS map where the epigenetic activity profile similarity is plotted on the Y-axis while the fingerprint-based structural similarity is plotted on the X-axis. An SAS map can be roughly divided into four regions as described in Figure