The results obtained by the kinases and the GPCR proteins, used as an external validation set for the model fitting and evaluation, point to the same general picture with aligned conclusions. The differences found (the effect of the sequence length on protein imbalance and n_interactions on predicted actives proportion is different to GPCRs) could be due to the fact that there is more imbalance of the GPCRs towards the actives. However, these results lead us to think that the guidelines for proteochemometrics models of this study provide sensible defaults to more protein families.