This suggests that CO2 primarily originates from MEK, hinting to a consecutive oxidation rather than a breakdown of an intermediate, such as the alkoxide, in a 2-butanol oxidation scenario. While the formation of CO2 lowers the selectivity by consuming the desired product, the absence of other organic compounds in the reaction products can also be interpreted as an advantage in terms of product separation. Concerning the effect of temperature, continuous flow catalytic tests using Co3O4 showed that increasing the temperature enhances both the catalytic activity and the yield, while the selectivity towards MEK is higher at lower temperatures.