Our trends explain the tendency found in the PDB for tetrahedral environments of Zn(II) and the interaction with mixed His and Glu/Asp coordination shells both in Aβ-Zn(II) and other protein environments in a relative number fully consistent with the trends determined in the present work. Therefore, the coordination of Zn(II) in these systems is highly dictated by the inherent prop-erties and affinities of Zn(II) towards its first coordination residues.