As the volume of landfilled solid waste continues to grow globally, the generation of leachate is expected to increase correspondingly. Landfill leachate contains a complex mix of contaminants, including PFAS. Its high variability in PFAS concentrations necessitates robust, and adaptable treatment technologies. Studies should emphasize the requirement for systems capable of handling this variability effectively. Drinking water is a critical area for PFAS treatment due to its direct impact on public health. Recent EPA regulation for PFOA and PFOS in drinking water aims to protect communities from the adverse impacts of PFAS including cancer, and developmental impacts in children, and infants. Meeting the stringent levels of PFOA and PFOS concentrations requires highly effective and sustainable treatment technologies, which are still not adequately covered in current literature. Understanding the specific challenges and opportunities of each water type allows for better tailoring of PFAS treatment technologies to achieve sustainability in environmental, social, and financial terms. This comprehensive approach ensures effective mitigation of PFAS contamination across various water sources. of the SI.