Solubility is the property of a chemical solute dissolving in a solvent to form a homogeneous system. Solubility depends on the solvent used and the pressure and temperature at which it was measured . While the solubility of solids in the majority of organic solvents plays an essential role in various chemical fields such as organic chemistry, environmental chemistry, organo(photo)catalysis, and petrochemical industry; the solubility data in specified solvents such as water or dimethyl sulfoxide (DMSO) is highly crucial for drug development . For example, low solubility in water is attributed with poor bioavailability because compounds that are non-soluble in DMSO could not be used in automatized high-throughput screening (HTS).