Metabolites, a group of small biomolecules with hydrophilic and hydrophobic compounds with molecular weights less than 1,000 Da, constitute the basic components of biological tissues. They are also important as phenotypic determinants of food materials in live animal and plant tissues because metabolites such as amino acids (AAs), lipids, and nucleotide phosphates function as flavor-related components after harvest . Moreover, metabolites in biological tissues, including animal blood, represent phenotypic signatures of tissue samples, which can be utilized to monitor and evaluate tissue growth and product quality.