Figure shows the ion plot of both features removed by the DOM filter and remaining ones, generated by the sample used for method comparison extracted with SAX-SPE (n = 3). To our knowledge, this is first time such a DOM feature reduction filter has been successfully implemented and applied for NTA of water. Though peak detection and alignment parameters were set to ensure detection of substances at low concentrations, library matches generated by features with low signal and no detectable isotopic compositions were discarded but via manual data-processing. The development of an automated workflow capable of performing all stages of the workflow for SS was beyond the scope of this work, but should include this DOM feature reduction step, together with customised databases and automatic selection of features with isotopic composition compatible with candidate elemental formula to considerably reduce the time required for data-processing.