Consistent with the tumor growth data, tumor weight measurements also confirmed the tumor eradication effect of EH@Ag2S +US group in tumor-bearing mice models (Fig. ). In general, Hematoxylin and eosin (H&E) staining and Terminal dUTP Nick End Labeling (TUNEL) staining were used to evaluate the pathological changes of tumor tissue after different treatments (Fig. ). For H&E staining, EH@Ag2S +US group exhibited much greater cell damage and resulted in the highest apoptosis degree.