Vesicle membranes can exhibit pore-forming behavior and rupture when the membrane is stretched until critical lysis tension is exceeded. The lysis threshold varies depending on membrane composition; for instance, the threshold is 5-10 mN/m for phosphatidylcholine membranes, and higher values (>20 mN/m) are measured for polymer membranes. Inspired by this, we selected vesicles as signal transducers capable of releasing molecules when the mechanical stimulus is applied to deform and rupture them. As phospholipid vesicles are known to exhibit low physical stability and a short lifetime, we employed phospholipid-block copolymer hybrid vesicles for improved physical stability (Figure ).