Non-specific inhibition can be a double-edged sword. Dong (2014) demonstrates that the aglycone kaempferol increased IAV viral titers by log-2 compared with untreated mice, hastening their loss. This was attributed to attenuation of antiviral host-defense factor expression such as IFNα, IFNβ, IFNγ. By contrast, hesperidin was protective of the mice. Further laboratory and clinical investigation of demonstrably promiscuous-binding polyphenols in in vitro viral infection culture and in vivo will continue to be valuable. Results of recent clinical trials of a polyphenol, quercetin, even while preliminary, do encourage further investigation. Attention would be particularly appropriate against those viruses that are known to induce inflammatory responses such as influenza A (IFV-A), dengue (DENV), chikungunya (CHIKV), and coronavirus (SARS-CoV-2).