(iv) An aqueous solubility of 10 6 mg/L (equivalent to 1 kg/L) for a substance is exceptionally high. This observation could indicate either an error or a special case occurring under specific conditions that are not typical for most substances at room temperature and atmospheric pressure. Most neutral organic compounds exhibit low solubility in water. We excluded 41 records reporting solubilities of ≥ 10 6 mg/L from our analysis.