There exist two major requirements in such catalyst design; (a) establishing a methodology for tailoring the requisite scaffold, and (b) codifying the essential descriptor that effects the requisite catalysis . While enzymes could serve as initial scaffolds, their low thermal stabilities and tolerance towards the organic solvents make them inapt and requires an extensive random mutation in the protein matrix . Viable alternatives are supramolecular complexes, such as organic cages, which are smaller than enzymes, while possessing active-site architectures akin to enzymes . Herein, we describe such a supramolecular cage.