For multi-conformational docking of the selected compounds, we prepared the NSP15 structure with Protonate 3D application, isolated the ligand and pocket, visualized the space available for docked ligands, defined the binding pocket based on the known key residues for its nuclease activity and uridine specificity, and generated ligand conformations using the bond rotation method. The compounds were docked into the pocket using the Triangle Matcher Method and London dG scoring for placement; and the Induced Fit Method and GBVI/WSA dG scoring for refinement. Poses were ranked by GBVI/WSA binding free energy calculation in the S field. The 56 random control compounds were selected from the FDA drug database.