Due to the lack of known structures, direct visual inspection between the confirmed ML-nominated hits and the enriched DEL PTEs was not possible. However, the fingerprint representation enabled the use of the standard Tanimoto similarity metric . All seven active compounds had a maximum Tanimoto coedicient (using FCFP4 fingerprints) above 0.5 when compared to DEL PTEs. These higher similarity values are generally interpreted as the ML-nominated hits being similar to the DEL PTEs. However, all confirmed ML-nominated hits also had a maximum Tanimoto coedicient above 0.5 to non-binders (NTEs) DEL compounds. This complicates the use of Tanimoto similarity as a reliable tool for distinguishing binders from non-binders among ML-nominated hits.