Across both the cAMP and ethane systems, and regardless of the specific softcore treatment employed, a consistent and clear trend emerges from the data: increasing the simulation timestep is strongly correlated with an increase in the total energy drift. This observation underscores the importance of carefully selecting an appropriate timestep for molecular dynamics simulations, particularly when aiming to accurately capture thermodynamic properties and maintain energy conservation throughout the simulation. Data presented here suggests that while smaller timesteps offer better energy conservation, they also increase the computational cost of the simulation. Therefore, a balance must be struck between accuracy and computational feasibility when choosing a suitable timestep.