As mentioned earlier, some binary azeotrope mixtures lose azeotropic behavior when the system pressure is changed. In this case, separation can be achieved without using Fig. Reactive Distillation Process This technique embodies simultaneous reaction and separation. Catalysts are enclosed in special packing inside a distillation column. This method uses distillation to remove products as they are formed in order to shift the chemical equilibrium of a reaction towards 100% conversion shown in Fig. .