As the products of the FR increase in number, and as their MW increases, the diversity of their chemical properties also increases. This diversity can be estimated using numerous metrics, including the Hybridization Ratio (Figure ), and Estimated Molecular Complexity (Figure ), which were estimated using chemoinformatic techniques . As would be expected, as product molecules grow larger, the range of property values they can explore grows. While HCHO and GA are particularly low flexibility molecules, carbohydrates in general are often high flexibility molecules, thus the products of the FR also grow into a region that produces very "floppy" molecules. Figure . A. The generational diversity of HybRatio as a function of generation in the FR CRNR. HybRatio is defined as the ratio of sp 3 hybridized carbon atoms in a molecule over the sum of sp 2 and sp 3 hybridized carbon atoms (Nsp 3 /(Nsp 2 + Nsp 3 )) . B. Estimated Molecular Complexity as a function of mass and generation in the computed FR products .