When trying to move away from fossil raw materials and to replace them with renewable raw materials, the development of new efficient processes is essential. Lignocellulose still has untapped potential as renewable raw material, especially the 30 -50 % cellulose it contains, which makes cellulose the most abundand (bio)-polymer worldwide. Of the 170x10 t lignocellulosic biomass produced annually, only 3-4% are currently used for food and non-food purposes. Once digested, various platform chemicals such as 5-hydroxymethylfurfural and furfural can be obtained from cellulose. Conventional aqueous digestions, like acid hydrolysis, were typically carried out with sulfuric acid or hydrochloric acid at temperatures of 100-180 °C, leading to monomeric sugars. An alternative to conventional digestions is mechanochemistry, which has advanced in recent decades and was acknowledged as one of the top ten emerging technologies in chemistry by IUPAC in 2019. As a solvent-free process, mechanocatalysis enables lignocellulose digestion through the combination of mechanical forces and a Brønsted acid. Mechanocatalytic partial depolymerization of lignocellulose, cellulose and hemicellulose is carried out with a strong acid (pKa below -1.8 ), e.g. sulfuric acid, and shows remarkable differences regarding the reaction process and the product spectrum. In contrast to conventional processes, mechanocatalytic treatment produces oligomeric sugars, so-called glycans and xylans, instead of monomeric sugars. Hereby a polymerization from glucose itself occurs which inhibits a complete depolymerization to monomeric sugars. It should be emphasized that the temperature is limited to about 90 °C due to follow-up reactions starting from monomeric sugars up to carbonization of the substrat. In addition to the mentioned platform chemicals, glycans represent a promising class of substances based on renewable raw materials. In a previous study we showed that meachanocatalytic partial depolymerization of lignocellulosic materials, e.g. apple pomace, to glycans with a molecular weight between 1-10 kDa is possible, whereby the yield is dependent on grinding duration and acid content. In this work, the process of mechanocatalytic partial depolymerization of cellulose as model substance is systematically investigated in order to obtain a high glycan yield. The aim is a systematic study to understand the influence of the various reation parameters in mechanocatalytic depolymerization of cellulose to oligomeric glycans.