The results of this study illustrate that photochemical oxidations can be carried out effectively with high productivity in a pRS-SDR. By improving mass transfer and with enhanced mixing in our reactor system, we were able to reach 1.1 kg•day -1 levels of productivity with full conversion of the substrate, without even optimizing the reactor design and photo intensity. Furthermore, we reached selectivity of over 90%, thus reducing the need of downstream processes for purification, and increasing the efficiency of the overall process. Therefore, the pRS-SDR can be used as a novel photochemical reactor for the facile scale up and intensification of multiphase, photocatalytic processes. In recent years, microreactors have been shown to intensify photochemical processes and therefore have been proposed as a scale up method. However, the challenges associated with microreactors, such as high pressure drops and changing flow patterns often prevent the technology from being applied at industrial/pilot scale. On the other hand, the pRS-SDR operates without any significant pressure drop across the reactor and the formation of dispersed bubbles are dependent on the rotation speed of the disk, rather than the imposed flowrate. As a consequence, this allows the pRS-SDR to be very suitable for the scale up of photochemical reactions. Throughout this paper we have investigated various process parameters which we believe influence the efficiency of the reaction. With further optimization of such parameters (i.e. photon flux, backpressure, substrate concentrations and mass transfer), further improvements in productivity are expected to be gained. Furthermore, the applicability of RS-SDRs for multiphase reactions makes it particularly interesting for further investigations of other kinds of photochemical reactions.