The type of buffer used to complex plasmid DNA was also found to regulate the morphology and surface density of adsorbed plasmids . In turn, the brush chemistry was found to modulate the adsorption of oligonucleotides, and their rate of desorption upon internalisation, through competitive binding with cytosolic macromolecules . Therefore, the macromolecular structure and solution morphology of polymer brushes have been found to play important roles in regulating the adsorption and intercalation of oligonucleotides and plasmid DNA, and are proposed to control not only the complexation but also the cytosolic release of the genetic cargos. Such impact of polymer brush chemistry, structure and morphology on macromolecular interactions is in good agreement with self-consistent field theories, scaling theories and coarse grain molecular dynamics simulations predicting an impact of the brush thickness, grafting density, solvation and chemistry (impacting brush-macromolecule interactions) on the infiltration of brushes by proteins, particles and polyelectrolytes .