The D. E. Shaw research institute studied the dynamical ensemble of the s-glycoprotein by performing a 10 µs MD simulation starting from the closed cryo-EM structure mentioned above (PDB ID: 6VXX). This simulation became stable after 6 µs, as shown by the root-mean-square deviation (RMDS) plot (SI-Figure ). Due to the s-glycoprotein's high flexibility, the cryo-EM structure lacks several parts of its sequence, causing several segments to be seemingly disconnected from the rest of the structure.