Next, as a means to select a candidate for evaluation in an in vivo model for inflammatory pain, cheminformatics analysis of physicochemical and pharmacokinetic properties was carried out using QikProp (Schrödinger, LLC). Molecules were loaded into Maestro and prepared for computational analysis. Using the OPLS3e force field the protonation states at pH 7.4 were determined and energy minimization was performed. Since the presumed site of action for our compounds is in the CNS we have given consideration to molecular properties that could affect blood-brain barrier (BBB) permeability. Several analyses have been published on physicochemical properties that drive BBB permeability and in general the consensus is that molecules with molecular weight < 400 g/mol and LogP ranging from 2 -5 have increased probability for CNS activity. The molecular weights of the four prioritized analogs range from 337 g/mol to 355 g/mol and QPLogPo/w ranged from 2.32 -2.88 (specific values for selected analogs provided in Table ). Conversely, the Polar Surface Area (PSA) for the analogs is maintained around 100 Å 2 .