The consistency between the Le Chatelier's Principle-like perspective and the molecular orbital theory interpretation of charged point defects highlights the simple chemical framework from which we can explain the electronic structures of defects in materials. However, it is not always obvious how such defectinduced molecular orbital states are created, nor where in the electronic structure they form. Here, we use symmetry principles and Density Functional Theory (DFT) calculations to guide a chemical interpretation of charged point defects in materials. We derive chemical interpretations of each native defect in Mg 2 Si to demonstrate the simple framework from which we can explain the charge states of point defects. We anticipate that the framework will provide a valuable chemical intuition for defect-induced electronic states that critically affect properties of semiconductor devices, such as photoluminescence, generation/recombination, and electrical transport.