Finally, Table indicates that the only rate constant that WE had within the reference confidence interval was for the folded → intermediate II rate constant. In contrast, the GaMD-WE had all of the rate constants fall within the confidence intervals except for the Table : Chignolin rate constants after 40 µs of simulation time. In the brute force simulation column, the first value indicates the average rate constant value, and the second value indicates the 95% confidence interval calculated from Bayesian bootstrapping. For WE and GaMD-WE, the error bars represent 95% confidence intervals calculated from the standard deviation of three independent runs.