The majority of the 6.7 million recombined molecules include fragments able to occupy 4 subpockets (90%), whereas the majority of original ligands is smaller and occupies three (53%) or two (28%) subpockets only. This is a consequence of a choice made in order to illustrate the power of exhaustive in silico library enumeration (the linking of fragments reaching up to four subpockets was allowed in this case). But most importantly, the presented workflow allows for tailored library design that can easily be adapted to fulfill the requirements of a particular project.