The first examples of chiral tetrahedral lanthanide MOCs with fascinating self-sorting behavior and characteristic Eu III luminescence features were described by Sun et al. in 2015. Two sets of enantiopure R-and S-ligands, i.e., bis(tridentate) L1 and tris(tridentate) L2 containing pyridine-2,6dicarboxamide units are devised, which after coordination with Eu III leads to Eu4(L1)6 and Eu4(L2)4, which are topologically chiral tetrahedral cages. During the process of self-assembly, the ligand's chirality is transmitted to the apical Eu III centers, resulting in either DDDDor LLLL-stereomeric tetrahedral configurations. Incorporation of an electron-deficient enantiopure ligand with Fe II afforded a Fe II 4L4 tetrahedron (MOC-12). This tetrahedron exists as a pair of distinct diastereomers adopting either an all Δ or Λ configuration of metal centers. However, encapsulation of an electron-rich chiral cryptophane-111 (CRY-A) dictated the diastereocontrol of the self-assembly process (Figure ). Whereas the Δ4 configuration was favoured by the MM-CRY, PP-CRY preferred the Λ4 configuration.