Using tetramisole With optimised conditions developed, the scope of the reaction was investigated. The effect of structural variation within the allylic substituents was probed (Figure ). Sequentially changing the R 2 substituent from methyl 3a through ethyl 3b and iso-propyl 3c increased the ratio of [1,2] Changing the nature of the R 1 N-substituents has a profound effect on the ratio of rearrangement products (Figure ). Variation of ring size showed that both piperidinyl and azepanyl derivatives The reaction can also be carried out on gram-scale, with propargylic amide 3v obtained in good yield and 88:12 er.