The Q/s strategy starts from a systematic conformational search to locate all possible conformers for monomers to tetramers, which are subsequently analyzed by means of statical thermodynamics, in line with quantum cluster equilibrium theory or the clusters-ina-liquid framework . Here, we used AutoMeKin 73 software, with some adaptations as explained in Section 3.2, to generate the conformational space. This results in a set of unique isomers for each aggregation size, containing 1 monomer, 38 dimers, 174 trimers and 144 tetramers. Each of them is optimized, and their second derivatives (frequencies) are subsequently computed at DFT/PCM level (see Section 3.1 for details).