During the gelation, nano-objects are trapped and physically stabilized into the matrix, resulting in the formation of the hybrid structure. For instance, an aqueous CS/β-GP solution at 2 and 10%, respectively, led to gelation in less than 20 s after raising the temperature to sustained drug release over a 160-h period (Figure ). While in this case entrapment occurs before administration, the use of thermosensitive polymers with LCST properties triggers gelation at body temperature allowing the nano-objects to be trapped in situ after injection and creating a sustained-release depot (Figure ). Copyright 2022 American Chemical Society.