Solubility in water of the obtained compounds at 25 °C was tested using the flask method described in the OECD 105 Guidelines . First, a preliminary test was performed, which consisted in adding increasing amounts of water to a determined amount (0.1 g) of test substance and shaking it for 10 minutes after each addition to determine an approximate solubility. Subsequently, exact solubility was determined for low-soluble compounds. First, a determined amount of pulverized solid, greater than can be dissolved in 10 cm 3 of water, was placed in 3 glass vials, and then water (in 10 cm 3 aliquots) was added to each vial. In addition, 2 more vials containing the same amount of water, but 2 or 3 times more test substance, were prepared to establish the effect of the dissolution of potential impurities on the solubility results.