with a high yield of 96% and 95% HPLC purity after washing of the reaction mixture with water, filtration, and drying. The same yield was achieved after scaling up the reaction threefold, from 100 mg to 300 mg loading of 6, while still using the same 14 mL milling jar and two 10 mm milling balls. HPLC-MS analysis of the crude product revealed that the primary impurities were unreacted 6 (1.3%), quaternary salt 19 (2%), and 20