Fig. | Overview of the strategies for enantioselective C(sp 3 )-H oxidation. A, Challenges of enantioselective oxidation of C(sp 3 )-H bonds. B, Effect of electropositivity at the copper center. C, Design for enantioselective oxidative coupling of C(sp 3 )-H with carboxylic acids using a molecular copper catalyst. PMP, para-MeOC6H4. DTBP, di-tert-butyl peroxide.