Further, we look into the complete-protein region of the WT and compare it with the mutant proteins (Fig. ). In the WT we observed the strong correlation between the protein residues 420-538 and 560-685 as shown in box c and b respectively. The strong anticorrelation behaviour is observed for the residues 565-690 (shown in box a and d). This pattern of correlation is completely disturbed for the mutant cases. Hence it is quite evident that the mutation reduce the correlations among the residues . It further indicates that the mutations affect the long range dynamical correlation and affect the overall protein dynamics of the residues.