As described in the Methods section, fragments and "Fragments RO3" were analyzed using fourteen constitutional and complexity descriptors. Table describes the constitutional and complexity descriptors of NPs from LANaPDB and COCONUT. Tables and summarize constitutional and complexity descriptors from fragments and "Fragments RO3." The fraction of carbon, oxygen, and nitrogen atoms for LANaPDB's compounds were 0.8, 0.19 and 0.01, respectively, and close to COCONUT's compounds 0.78, 0.18 and 0.04. Chavez-Hernandez et al. (2024), reported the structural composition of NPDBEjeCol, BIOFACQUIM, NuBBEDB, PeruNPDB, FDA-approved drugs. Similar to this study's COCONUT and LANaPDB, all databases of natural products maintain a tendency for a higher fraction of carbon atoms, presenting a higher content of oxygen atoms than nitrogen atoms. While this behavior is distinct in libraries that contain synthetic compounds, for example as FDA-approved drugs (the fraction of carbon 0.68, oxygen atoms 0.17, and nitrogen 0.09). This corresponds to what has been reported in the literature. The fraction of carbon, nitrogen, and oxygen atoms for LANaPDB's fragments were 0.75, 0.24 and 0.01, and were similar to LANaPDB's "Fragments RO3" (0.8, 0.18 and 0.01). However, the total number of carbon atoms shows a difference in the fragments from LANaPDB with respect to the reference libraries. A reduction in the fraction of oxygens of reference libraries ca. 0.1 compared to LANaPDB was identified, finding values with a range of 0.10-0.12 for fragments and 0.8-0.9 for "Fragments RO3". In contrast, the fraction of nitrogen increased >0.1 in reference libraries compared to the displayed value of LANaPDB, with a range of 0.12-0.16 for fragments and 0.12-0.14 for "Fragments RO3". This is consistent with reports in the literature, the PN often has more oxygen atoms and fewer nitrogen atoms than synthetic molecules. This may be due to the fact that while nitrogen is a necessary component of nature, it is more specialized and therefore less prevalent in organic compounds, while oxygen is a frequent constituent in the biochemical reactions of PN and is so found in more metabolites. The carbon fractions of the COCONUT fragments 0.71 were similar to "Fragments RO3" of COCONUT 0.78. COCONUT has a similar behavior to that presented by LANaPDB in the fraction of oxygen decreases and nitrogen increases in reference databases.