with tunable orientation and long-range order are promising materials for the design of biofunctional and nanostructured coatings. In addition to HEA integration and polymerization in the bulk cubic phase, the structural effect of hydration and polymerization in GMO films was investigated with GISAXS. Films of GMO60HEA5 and GMO55HEA10 were prepared on silicon wafers by dissolving the mixtures in ethanol and drop casting onto the wafer surface. The formation of a homogeneous film was previously reported by drop-casting GMO-ethanol solution on an untreated silicon wafer surface. The GMO/HEA mixture in ethanol spread completely on the plasma-treated wafer with an approximated contact angle of zero. However, the presence of HEA in the film led to partial de-wetting of the substrate. This effect could be prevented by immediate immersion of the film in water after ethanol evaporation, which helped wet the wafer surface, leading to a homogeneous film.