Despite the glycosylation reaction being one of the most investigated reactions since the introduction of the Fischer glycosylation in 1893 , new insight and new glycosylation methodologies are still desired. This is partly due to the high substrate-specific nature of carbohydrates, making a one-fit-all glycosylation method nearly impossible to establish. Most glycosylations are substitution reactions taking place through a mechanism somewhere on the SN1/SN2 spectrum , where an electrophile (the glycosyl donor) reacts with a nucleophile (the glycosyl acceptor) to form a glycosidic bond that can have two different orientations (α or β). An illustration of a generic glycosylation can be seen in Figure .