The amic acid derivatives described above also represent excellent starting materials for addition of bulky amino acids and peptides to the secondary face. Following the same reaction procedures used for 6, we coupled methionine, lysine, cysteine and β-phenylalanine to 1, producing 7, 8, 9 and 10 at yields ≥ 65%, giving an overall reaction yield of ≥55% from 3-NH2-β-CD. To further validate this approach, we coupled the tripeptide glutathione to 1, yielding 11 at 58 % yields (Scheme 1). Again, isolation and purification of 11 was achieved without the need for chromatography. Interestingly, NOESY NMR suggests that the pendant arm does not self-associate inside the CD cavity [Figure ].