When analyzing the ranking of compounds based on AutoDock Vina binding energy, most of the true binders are predicted to have a better binding energy compared to the non-binders (Fig. ). Indeed, in the first quartile of the ranking, 36 out of total 47 ligands (77%) are binders. The enrichment of results decreases when proceeding toward lower quartiles, with 60% of the binders scoring better than the average ranking of the 186 total ligands. A similar trend was observed when considering ligand efficiency as a parameter to discern between different classes of ligands. Fig. shows that ligand efficiency of binders is higher on average compared to that of non-binders (-0.27 vs -0.35, p<0.001).