Pearson's correlation coefficients fall between 0.26 and 0.82 for EQ and between -0.07 and 0.80 for NEQ across all systems. For the full dataset, the EQ approach agrees better with the experimental data as compared to the NEQ approach with differences between their MUEs and RMSEs being 0.22 and 0.30 kcal/mol respectively. On comparing individual systems, all but two systems have RMSEs differing between EQ and NEQ approaches by less than 0.5 kcal/mol (after adjustment with ∆G prot conf ). So, the difference in accuracy between the two methods is primarily due to ROS1 and TYK2, where the NEQ method performs much worse compared to the EQ method (RMSEs differing by 0.60 and 0.84 kcal/mol respectively). The difference in precision of the two approaches is even more stark: the numbers of complexes with uncertainties greater than 0.5 and 1 kcal/mol are 5.48% and 0 for the EQ approach, whereas 51.15% and 6.85% for the NEQ approach. Further, the range of uncertainties is 0.14-0.87