It is thought that the reduction of the nitro moiety in nitrofuran antibacterials brings about reactive species, which in turn damage the bacterial DNA, inspired by this hypothesis, and given that a simple boronic acid moiety has a vacant p-orbital to which nucleophilic amino acid residues such as serine, cysteine etc. in bacterial proteins, and nucleophilic purine and pyrimidine bases of bacterial DNA can bind so as to interfere with metabolic activities of pathogens, and cause bacterial cell death, as a proxy for biological evaluation of these novel NInC hybrids the nitro warhead in nitrofurazone antibacterial was successfully replaced with a boronic acid in just one synthetic step (Scheme 11) to give boronic acid 38 in excellent yields i.e. 90-95%, and purity as evidenced by H NMR (ESI S56 †).