We were able to see the difference in the protein ligand interaction in both the models by docking of these ligands to the whole surface of a protein. As we had no prior knowledge of the target pocket. As the docking involved several runs and energy calculations for arriving at a favorable protein-ligand complex, the interactions observed shows that the interaction profile of ligand AZP with amino acid residues of the homology Model of SARS-CoV-2 3C like