Among the compounds, only compounds 10e, 13a, and 21a have less than 5 ml/min/kg suggesting that they have low clearance. All other compounds have their clearance within the range of 5-15 ml/min/kg which categorized them as compounds with moderate clearance. Except for compounds 8d and 21a which scores (0.717 and 0.626) suggests that their half-lives maybe less or equal to or less than three hours. All other compounds have their scores greater than three hours according to the results in Table . Half-life (T1/2) refers to the time required for the plasma concentration of a drug to decrease by 50%. The T1/2 of the initial phase (alpha-phase T1/2) represents the distribution of the drug, and the T1/2 of the second phase (beta-phase T1/2) represents the elimination of the drug from the body. The T1/2 results reported herein are the beta-phase T1/2.