In contrast, the other binding pocket exhibits a more reduced character. This is evident from the upfield shift of the second set of naphthyridine resonances, indicating dearomatisation of the naphthyridine pocket. This dearomatisation is also reflected by the upfield shift of the resonance of the methine proton to δ = 6.79 ppm, resulting from a decrease of its aldimine character. The magnetic inequivalence observed for the dipp -CH 3 resonances in 1 is absent in the non-reduced pocket of 2, where a single doublet is observed at δ = 1.18 ppm ( 3 J H,H = 6.8 Hz). The opposite is true for the reduced pocket of 2, which is apparent through the presence of two slightly overlapping doublets at δ = 1.12 and 1.11 ppm. This magnetic inequivalence can be indicative of constrained rotation around the aniline C-N bond on the NMR timescale, which we ascribe to the introduction of Ge into the reduced pocket.