The DIABLO analysis (Figure ) indicated that PD-/LRRK2+ clustered separately from the rest of the groups (left), while some iPD and control samples cluster together (right). This classification is mainly driven by the metabolomics/exposomics data, as most of the selected features are chemicals. Interestingly, two of the selected features are PFAS, PFBuS and 6:2 FTSA, which have lower levels in the PD-/LRRK2+ group compared to the controls, as previously indicated (Figure and Figure ). Sample plots from the final DIABLO model in Figure display the degree of agreement between the two datasets. Importantly, the PD-/LRRK2+ samples clustered together in both metabolomics and metagenomics datasets. Certain species within the genus Rhodococcus have been reported to degrade BThSO3 (Figure ) to OBhT (Figure ) , . Furthermore, BTh can be degraded by several bacterial species including Rhodococcus sp., Pseudomonas sp., Arthrobacter sp. and Enterobacter sp. . Interestingly, all of these were identified in the dust samples, although only the first three species were included in the filtered dataset (Table ).