The second example focuses on the electrochemical formation of C 3 prod- As for pH effects, shifting towards a more alkaline pH (from pH 7 to pH 13) leads to an increase of the reaction energy for all PCET reactions. This behaviour is expected since increasing the pH implies a lower concentration of protons, thermodynamically disfavoring the protonation of the intermediates. As expected, lowering the applied potential (from -1.0 to -1.5 V SHE ) leads to a favorable thermodynamic shift of the energies for all PCET reactions.