In previous work, no attention was paid to the environmental fate of quinine-based QASs as a new type of pollutant, nor did they consider the toxicity of these compounds to living organisms. In order to mitigate negative environmental effects, in the course of designing the new compounds, the strategy of obtaining new naturally-derived QASs was extended. The cation derived from the plant alkaloid was combined with natural anions of L-asparagine and L-alanine, proteinogenic amino acids that constitute the building blocks of proteins in living organisms. There is no information about harmful effects of these amino acids on human and animal health . The synthesized quinine-derived QASs were subsequently tested in terms of their lipophilicity, antimicrobial activity, biopesticidal activity toward pest insects, and their toxicity toward terrestrial plants and aquatic organisms. The results obtained in the course of this study allowed a meaningful determination of the application potential of the new quinine derivatives, as well as the risks associated with their possible introduction into the environment.