On the GDCCs, as for TrimerTrip, submissions using the AMOEBA force field and absolute alchemical binding free energy techniques performed particularly well. Additionally, along with a QM based method, these AMOEBA-based approaches correctly predicted exoOA with g1 a non-binder. Perhaps only AMOEBA and QM methods capture relevant polarization effects well enough to accurately describe this particular complex well in general, though one MM/PBSA approach also recognized this as a nonbinder.