For the above reasons, a strategy of replacing toxic QASs characterized by low biocompatibility with safer active substances of natural origin and taking into account environmental risks of their production and use is reasonable . This approach involves replacing fully synthetic cationic QASs with salts of natural origin, including amphiphilic betaine derivatives , which can be obtained in sustainable ways and are characterized by lower ecotoxicity. A particularly interesting variant of this strategy consists in the use of natural compounds with favorable physicochemical or biological properties as a scaffold for new active ingredients. For example, quinine, the oldest, naturally derived antimalarial drug, is currently attracting considerable interest in the scientific community and provides a promising foundation for the structures of active pharmaceutical ingredients . In this regard, it should be noted that recently effective methods have been developed for obtaining QASs with a cation derived from quinine , for which a number of beneficial applications have been proposed to date. Quinine-based QASs may be applied as catalysts for stereochemical reactions that are stable in alkaline media , modifiers for enantiomer separation , and plant growth regulators . Due to the confirmed antifeedant properties toward insects exhibited by quinine , the prospect of application of quinine-based QASs as biopesticides to reduce insect feeding on plants and stored grain is also a very promising direction . The search for new ways to counteract insect feeding in a sustainable and environmentally safe manner is particularly important, since ongoing global warming significantly contributes to the increase in insect metabolism, as well as their need for food. In the case of a 2 °C temperature rise compared to the pre-industrial levels, yield losses caused by pest insects could increase by as much as 46% for wheat, 13% for rice and 31% for corn . Given that the projected increase in global temperature is very likely to reach 2.5-2.9 °C by the end of this century according to the latest UN report (United Nations Environment Programme, 2023), pest activity is also expected to rise faster and to higher levels.