In addition to this T4 lysozyme data set, an additional set of proteins with fewer than 200 residues but much larger ligands was chosen for additional tests. This data set ranges from the compact tyrosine kinase structure (PDB: 1O48) to a large inhibitor of dihydrofolate reductase (PDB: 1BOZ). In ascending order of size, they are 1O48, 67 1ZP5, 69 1MMQ, and 1BOZ. All of the ligands, which are depicted in Fig. , serve as inhibitors and we refer to this set of complexes as the "large inhibitor data set" (LIDS).