It can be seen that for IsA, the majority of the methods agree on the structure with RMSD values of less than 0. Based on the monomer geometries, it seems that all the methods achieve low RMSD values and are suitable for obtaining the structures. For SA-W clusters we usually use a criteria of a minimum value of 0.38 Å for evaluating uniqueness, if this is also applicable for these monomers, then it can be noted that all the methods find the same lowest energy structure for IsA and IA.