To conclude this INS360 section the challenges presented by the informatics de facto multistop-shops need to be spelled out. As the cliché puts it "an hour of informatics can save 100 hours of experimentation". This means on the one hand ADEV teams have never had it so good for pursuing in silico approaches that could save a lot of lab time. On the other hand, it also means the necessary expertise needed to execute those comprehensively and efficiently continues to widen. We can take the powerful document-to-document 'walking' example mentioned above for SF. This can be done analogously across the ChEMBL, SureChEMBL, PubChem, PubMed, Entrez axis (and there is new orthogonal patent < > paper citation connectivity available at the LENS) . While public coverage is lower, this is balanced against the entire system being interlinked (i.e. we can click more or less from anywhere to anywhere). In addition, these public resources not only facilitate downloads but parts of them are also computationally accessible (e.g. GtoPdb web services, ChEMBL RDF , web services NCBI PUG and ELIXIR interoperability). Considering the essential (but expensive) complementarity of commercial products there are also integrated query options such Cortellis for Integrity and STN for SF. However, neither would supply handy tips for linking entities between the two. The problem for ADEV support is that few people have the expertise to exploit the full functionality between even just those resources mentioned above.