"Metals in Biology" sessions were conducted in-person in 2019, and virtually due to pandemic restrictions in 2020-2021. While the 2019 in-person session involved students performing hands-on experiments, the 2020-21 sessions involved experimental demonstrations to students on Zoom. Each session lasted approximately an hour. At the beginning of the session, students took a pre-survey questionnaire (Figure ) followed by a 5-minute overview on the role of metals in biology, specifically what metalloenzymes are, and their roles in biocatalysis. After this initial discussion, students were grouped in teams of 2-3 for in-person sessions, and each team was provided a protocol for experiments that were to be conducted (Supplementary Information, S4-6). For the virtual sessions, instructors performed the demonstrations while students were encouraged to make hypotheses, observe, and take notes. The in-person session consisted of the potato and elephant toothpaste experiments only (Figure and), whereas two additional experiments ("iron in cereal" and "heme extraction", Figure and D) were introduced in the virtual Zoom format. After each experiment/demonstration, the experimental results were briefly discussed to educate students on the science behind the demonstrations and to address any misconceptions. At the end of the outreach, students were again asked to fill out the survey with the same questions to assess is there was any increase in awareness about the role of metals in biology after experiments/demonstrations. Below, we describe the experimental procedures, expected observations, and scientific explanations of the four experiments/demonstrations performed during the outreach.