All GAs are run with a population size of 25 for up to 50 generations. The mutation rate is set to 50 % which means that with a 50:50 chance either a crossover or mutation operation is chosen for the reproduction. Ligands with as many as 30 heavy atoms and/or 5 rotatable bonds are allowed. The starting population is created from combinations of ligands from a pre-defined list containing 91 different amines, phosphines, N-heterocyclic carbenes, pyridines and CO taken from Meyer et al. .