Whereas the overall slip-stacking behavior obtained at the PBE+D3 level is therefore similar to that obtained using XSAPT+MBD, several aspects of the analysis presented in Ref. 18 seem questionable. First, it is not clear how large the basis-set superposition error (BSSE) might be or where it appears in the various components of E int when the periodic EDA developed in Ref. 66 is applied. Although BSSE is often a minor concern at the DFT/triple-ζ level, it does grow with system size and we have documented examples where the BSSE in a DFT/ def2-TZVP calculation can be as large as 7-8 kcal/mol for systems with ∼ 300 atoms. For a layered material, BSSE should be size-extensive and will therefore increase in larger models of COF-1.