Ringtail comes with a specialized script (rt compare.py) to filter the same ligand library (i.e. containing identical ligands) docked against different targets by accessing multiple SQLite databases at the same time. The applications of this tool are numerous addressing very diverse challenges: targets can be entirely different proteins (e.g. cross-target specificity), different mutants of the same protein (e.g. mutant resistance), different sites on the same protein (e.g. orthosteric vs. allosteric binders), or different conformations of the same protein (e.g. conformation-independent binding). Potentially, this feature can also be used to perform consensus virtual screening across different docking programs. Ligands passing the comparison criteria can be exported directly as CSV files. Alternatively they may be stored as a view /bookmark in one of the databases considered, allowing access to the full set of sub-filtering and export options included with rt process vs.py.