Any information coming from the protein model can be used for vaccine development and for designing antiviral drug candidates In Silico Epitope, polyprotein and spike protein-based peptide vaccine designing for infectious viruses is a way that can hasten the process of vaccine development. Spike (S) protein, polyprotein and other viral proteins of the SARS-CoV-2 as a target for the development of vaccines and therapeutics for the prevention and treatment of infection is an important approach. In the case of SARS-CoV, these proteins can mediate binding of the virus with its receptor and promotes the fusion between the viral and host cell membranes and virus entry into the host cell, hence peptides, antibodies, organic compounds and short interfering RNAs that interact with the spike protein can have a potential role in vaccine development .