Finally, a non-rigorous implementation of multiple distance restraints was tested, based on the assumption of no coupling between internal and external degrees of freedom in the limit of weak restraints. The schemes tested were M-Hand, a repetition of M-Hand-R without releasing to a single distance restraint, and M-Hand-1, a repetition of M-Hand with all flat-bottomed diameters set to 1 Å, a reduction from the average diameter of 2.7 Å for M-Hand-R.