One key study to motivate the work with such large libraries was presented by Lyu et al. : Their docking of around 100 million compounds to two targets, β-lactamase AmpC, and D 4 dopamine receptor, did not only result in the discovery of novel ligands for both targets, but they made critical observations for many studies to follow: Firstly, they found that if docking enriches true positives over decoys on the small scale, enrichment can be expected to be translated to the ultra-large scale.