we are better able to distinguish between binding modes sampled within each sub-cavity and understand their timescales, over the timescale to transition between sub-cavities. In other words, we can better distinguish rapid transitions between binding modes within each sub-cavity over the slow transitions between sub-cavities. Additionally, if we had pooled together simulation data from both sub-cavities, our silhouette scores would always suggest 2 binding modes, which is actually just the separation of binding modes between the two cavities.