MVS-A consistently matches or outperforms the other baselines both in terms of false positive and true positive detection. Crucially, it provides average improvements up to 50%, 13% and 14% in terms of relative precision, enrichment factor and BEDROC against primary readout sorting, a popular heuristic used in the pharmaceutical industry for HTS hit prioritization. Concerning false positive discovery, our method can identify a wide range of structurally diverse interferents with low overlap with the predictions of prior insilico tools, making our method an excellent addition to HTS false positive detection pipelines.