In 1966, Cyrus Levinthal published "Molecular Model-building by Computer" along with the first interactive display for visualization and manipulation of molecular structures 1 that revolutionized the field of molecular visualization. Before the introduction of more advanced virtual systems, physical ball and stick models were developed and used by several scientists, such as Watson and Crick to investigate the structure of DNA and John Kendrew to solve the first crystal structure of protein . As the capabilities for creating virtual 3D environments advanced, the use of physical models decreased, and the physical ball and stick models have been replaced by a mouse, keyboard, and computer monitor. The current way of chemical structure modification along with 3D position and orientation involves the scripting of computer programs or the use of complex graphical user interfaces where inputs are given by a mouse and keyboard. Manipulation of molecules through such methods is complicated as it often requires extensive knowledge of programming or a deep understanding of the user interface. Such systems lag behind the state-of-the-art tools developed for human-computer interaction. Relatively simple actions such as repositioning molecules are only mastered after a steep learning curve as the many nuances required are difficult to understand for both professional researchers and students .