Scaffold analysis of natural products databases from various sources has been published recently. For instance, Núñez MJ et al. reported the scaffold diversity of 15 natural product databases. For that work, the authors used the scaffold definition of Bemis-Murko, and the scaffold diversity was measured using cyclic system recovery curves and scaffold counts. It was concluded that the collections of natural products from Brazil (in the NUBBE database) and the Panamanian flora (UPMA) are the most diverse. In contrast, the collections such as AfroDB, BIOFACQUIM, and other collections of natural products from commercial sources were the least diverse.