In general, our analysis reveals significant differences between BEP relations calculated on Cu and Pd for various elementary steps. This finding strongly deviates from the widespread understanding of BEP relations and their common application across various metals in computational catalyst design studies. In particular, the derived BEP relationships highlight the exceptional catalytic properties of Cu discussed earlier. Cu is calculated to be generally more active than Pd in hydrogenation steps despite the well-recognized activity of the latter in hydrogenation catalysis. Moreover, the only step with an unusually high hydrogenation barrier on Cu catalysts is the hydrogenation of CH3* to methane, which is considered an undesired product in most industrial processes. In turn, protonation barriers on Cu generally exceed 1 eV, contrasting with notably lower protonation barriers of Pd, which is in line with much more negative charge on H* atoms adsorbed on the former (Section S6). This finding highlights the need for promoters or co-catalysts to enhance the protonation steps on Cu-containing catalysts, in particular, OH* protonation, which is necessary for the production of water byproduct and regeneration of active sites on the catalyst. Moreover, copper's notable activity in metathesis C-C coupling (Figure ) This highlights the need for promoters or co-catalysts (e.g., Co) to facilitate the other higher-barrier C-O cleavage steps.