Most frequent scaffolds in COCONUT and DrugBank The 20 most frequent scaffolds in the COCONUT scaffold network and scaffold forest, respectively, as determined in this exemplary showcase analysis, are displayed in Figures and. The frequencies are given as numbers of origin molecules that produced the respective scaffold in parent scaffold generation or had it as an original scaffold. The frequencies for the network scaffolds correspond precisely to the number of molecules that possess the respective scaffold as a substructure, whereas the frequencies for the forest scaffolds correspond to the number of molecules that possess the scaffold as their most characteristic or central parent scaffold in one step of the Schuffenhauer dissection according to the prioritisation rules. Hence, 225,272 COCONUT molecules contain a benzene ring (Figure ) but only in 29,258 molecules, it is the characteristic or central parent scaffold (Figure ). Still, it is striking that the benzene ring is the most frequent root scaffold in the forest because some Schuffenhauer prioritisation rules explicitly assign a low relevance to it and favour its removal over that of other rings.