Further to go for Hantzsch type reaction we need an aldehyde and a nitrogen source. For the aldehyde source, we have chosen hexamethylenetetramine (HMTA) as it is known for in-situ generation of formaldehyde and for the nitrogen source we went ahead with ammonium carbonate and ammonium acetate for investigating. We have also investigated the reaction yields with various solvents such as water, ethanol and toluene. During the investigation, we have observed that the optimum reaction conditions for best yield were obtained using ethanol as solvent and HMTA and ammonium carbonate combinations at reflux temperature for 2 hours for the complete conversion of N-protected γ-amino β-keto ester (1a) to obtain 1,4-DHP (2a), shown in Scheme 2. Scheme 2: Synthesis of 1,4-dihydropyridines from N-protected γ-amino β-keto esters.