This process was repeated 25 times with a different randomly generated peptide and reiterated for each BO parameter, but only for 9-mers peptides. The impact of noise was assessed at various sigma levels: 0 (noiseless; reference), 0.5, 1.0, 1.5, and 2.0. The batch size was reduced from 96 (reference) to 72, 48, 24 and 12 peptides, selected at each DMT cycle. Different batch strategies were explored, including top-k (reference), CL, and KB. In addition, several acquisition functions were evaluated: EI as the reference, along with greedy, PI, and UCB. All the results were compared to a random search strategy, as described earlier.