Considering the mission scenarios outlined in the introduction, the decision for single or multiple landing sites affects the process configuration choice. For a single landing site, where multiple crews will subsequently be present, it is likely that water and thus hydrogen are abundant. Therefore, the SPO concept is the preferred choice due to its potential higher reliability, lower weight, and transportation costs. The RO variant may be preferred for continuous long-term operation at a single landing site, due to its efficient H2 utilization. The higher process complexity associated higher weight and transport costs, may be overcompensated by the process efficiency and flexibility.