Currently, we are in the era of "End to Modern Medicine if bacteria can resist" It is important to accept that a majority of infections caused by bacteria are resistant to antibiotics thereby making them ineffective. An experiment was conducted by where three geographically separated patients treated with the antibiotic Vancomycin were subjected to the harmful effects of the bacteria Staphylococcus aureus, to conclude the antibiotic was ineffective against the bacteria. ('Antibiotic resistancethe problem intensifies Gram-negative bacterial species have a cell wall which consists of lipopolysaccharides. They are a large unique class of macromolecules found in the outer layer of the cell wall and are involved in the interaction of the cell with the external environment. Due to the permeability barrier exhibited by its external layer, gram-negative species such as P. aeruginosa and E. coli are resistant to many drugs. These Gram-negative species have been a threat to humans for a long time and have been the lead reason for admissions into the intensive care units leading to a high risk of morbidity and mortality. Organisms have developed a wide range of mechanisms to prevent and resist the action of many antimicrobials and antibacterial drugs used in clinical medicine. Some of the mechanisms of resistance include efflux pumps, alteration of the drug binding site and membrane permeability, degradation enzymes, and the conformational change of the drug culminating in its inactivation. Herbal medicine and Ayurveda have been attracting great attention in recent years and are increasingly used as an alternative to the conventional chemical drugs available in the market. There are several publications and pieces of evidence that support the fact that medicinal plants provide a positive impact in the prevention and cure of a wide range of diseases at the same time with the benefit of providing minimum to no side effects.