Ultrasearch technologies targeting extralarge chemical spaces generated by virtual combination of fragments for easier chemical synthesis are now available (see Computational Methods).Alternatively, analogues to test for any possible high-docking affinities were tested. However, despite predicting H1R ADV affinities < 50 nM by ~ 20 % of 413NN2-ChemSpace 2000 analogues, their crossdocking failed to detect any specific analogues (not shown). These preliminary results suggested that the number of analogues required to find low crossdocking alternatives would be beyond the limited scope of this work.