For the synthesis of D-ribose-5-phosphates 11b,12b (Scheme 4B) reactions were again carried out at 20 mM substrate loading with the PEP/PK recycling system. The reaction conditions were again optimized by DOE, (supplementary 11.2.2) For all reactions of both cascades products were purified by anion exchange chromatography. For the synthesis of L-lyxose-5-phosphate analogues, 2-OMe and MOE products 11a and 12a were generated in good conversions (62%, 61% respectively) and isolated in reasonable yields (28%, 39% respectively). For the benzylated product 13a, conversion of 53% was obtained alongside an isolated yield of 25%.