The right panel of Figure presents the hydrate distributions of the pyruvate-containing clusters. In all cases, the clusters are highly hydrated with 2-5 water molecules. The (PA -) 1 (Na + ) 1 (Cl -) 1 (w) 0-5 clusters are found to be slightly more hydrated than the corresponding (PA -) 1 (Na + ) 1 (w) 0-5 clusters. This could indicate that Cl -exhibits a synergistic effect with Na + in thermodynamically stabilizing the higher hydrated clusters. Hydrate distributions obtained at 273.15 K and 258.15 K and at 50% relative humidity show similar trends (see Supporting Information).