Solid state NMR experiments have been useful in the detailed characterization of peptide interactions with membranes, yet they are inherently insensitive and thereby require large amounts of sample. This combined with the lack of generally applicable straightforward and robust sample preparation protocols complicates many practical applications of solidstate NMR experiments. On the other hand, preparation of samples with peptides interacting with detergent micelles or more realistic membrane mimics, such as bicelles or nanodiscs, for solution-state NMR experiments is often more feasible and requires less material. Even so, the interpretation of peptide-membrane interactions from solution state NMR experiments is often tedious because (i) reference direction defining the membrane plane that enables direct determination of order parameters is not well defined in solution state samples, and (ii) methods to interpret conformational ensembles and dynamics of aggregates of lipid-like disordered molecules from solution state NMR data are not available.