was also disclosed at an AACR annual meeting in 2021 . Atropisomerism has been a key feature of KRAS SII-P binders, with the moieties binding to a2-helix side been discussed across a number of compound series . The biologically active atropisomer of GDC-6036 has been disclosed, with the atroposelective synthesis well described . However, with LY3537982 this matter is not quite as well defined. There is limited available information related to the atropisomers of selected derivatives of the compound series in the patent, but no definitive information is given for LY3537982 .