The presented Cheminformatics Microservice is a self-contained, web-based service that operates independently of the operating system. This can be used by researchers with no or limited programming experience to perform daily cheminformatics tasks effortlessly via the API hosted at . This service allows a diverse range of open-source cheminformatics toolkits to be accessed without requiring any software installation or environment setups. To the best of our knowledge, it is currently the sole microservice in the field of cheminformatics offering users the ability to access multiple toolkits, as well as additional tools such as the open-source structure generator surge, Sugar Removal Utility (SRU), and the DECIMER OCSR tools. Cheminformatics Microservice is designed to be user-friendly, easily extendable, deployable, and scalable. It can be accessed through the public API or hosted on private clusters or single machines.