We performed ABFE calculations on 219 ligand-protein complexes comprising 186 ligands and 31 different protein targets (including 22 bromodomains). This is the first ever application of both equilibrium (EQ) and non-equilibrium (NEQ) alchemical approaches to predict absolute binding free energies (ABFEs) for an identical set of ligand-protein complexes at such a large scale, thereby permitting their direct comparison. We would like to point out here that all the results obtained from the NEQ approach discussed in this section use the "standard" recommended protocol (as detailed in the Discussion section). It requires differential NEQ transition lengths in the forward (800 ps) and the reverse (400 ps)