where L A and L B represent the total number of spatial orbitals in atoms A and B, respectively, and I ij is the mutual information between orbital i and j. A graphical depiction of this approximation is given in Figure , where the total amount of information between atom A and B is represented by summing over all orbital-wise information that exists between these two atoms (blue lines in Figure ). From now on we refer to the I paq AB as the (approximate) Atomic Mutual Information AMI which was used to measure the amount of correlation between constituent atoms of molecules. The validity of the approximation is investigated in Section 3. The practical utility of this approach is demonstrated on the set of all 400 possible dipeptides consisting two of the twenty natural amino acids. This choice of test set is motivated by two reasons. First, dipeptides are regarded as the smallest polypeptide chains, allowing for a more manageable computational load. Second, the use of all possible combinations of the twenty naturally occurring amino acids allowed for the creation of a large and sufficiently diverse library of 400 dipeptides. The results of our work not only allow for the validation of locality in organic peptide systems but also shed light on the bonding patterns and the strength of connections between atoms in dipeptides, offering a blueprint to extend such connections to larger polypeptides and even proteins.