Here, we define two sub-cavities (left/right) which are separated by two loops which form at residues VAL381 (A) and VAL499 (B), creating a cleft in the center of the SEH binding site (Fig. ). Throughout this study, we treat the left and right sub-cavity separately as we did not observe transitions between them in our simulations. By performing our analysis on each sub-cavity separately, we are better able to resolve the binding modes and timescales for transitions between binding modes, relative to trying to resolve the transition timescales between the sub-cavities.