Overall, thanks to many recent advances in CPS methodology, most of the ribosome appears to be within current or near-future reach. The D-ribosome project, however, will be a massive undertaking likely requiring combining diverse approaches and contributions from many groups. We therefore urge labs developing new CPS methodology to consider ribosomal proteins as model systems to showcase tools, as each synthesis and the data it provides will be a valuable stepping stone toward this shared goal.