The Co-Precipitation Method is a simple and effective approach to incorporate hydrophobic molecules like Curcumin into nanoparticle system, which enhances its bioavailability and functionality. This technique is employed for the synthesis of Amorphous Calcium Phosphate (ACP) loaded Curcumin Nanoparticles. In this method initially Calcium Nitrate is dissolved in deionised water to achieve a 1mM concentration which forms the base solution. Subsequently and incremental dropwise addition of Ammonium Hydrogen Phosphate in the solution is done which leads to the formation of a stable white suspension that indicates successful precursor preparation.