We have also investigated the enzymatic degradation of the same set of polyesters (10, 11, 14, and 15) with the engineered Ideonella sakaiensis PETase variants S238A with affinity towards crystalline domains of PET, thermostable Dura variant of PETase, as well as the leaf-branch compost cutinase (LCC). The polyesters were enzymatically degradable to different extents using these biocatalysts, generating 3-17 % of monomers based on the 1H NMR analyses (Figure -S20). The molar mass of the polymers following enzymatic degradation was analyzed by SEC (see the SI, Figure , Table ), clearly showing the hydrolysis and release of oligomers in addition to the monomers. Further optimization of the reaction conditions is needed to improve the yields of the monomers from the enzymatic degradation, still, the data shows significant enzymatic degradation without any mechanical or chemical pre-treatment step.