The "small" systems considered here have up to ∼ 20 heavy atoms, which is certainly not a hard limit on good performance but represents the largest dimers in standard small-molecule data sets such as S22 and S66, for which DFT methods have been exhaustively vetted. Significantly larger systems with 100 atoms pose both a challenge and a conundrum. The quality of the reference data can be difficult to assess for systems of this size, and indeed the best-available ab initio benchmarks for nanoscale vdW complexes differ from one another in a few noteworthy cases. Nevertheless, the analysis presented herein makes it clear that the sub-kcal/mol accuracy of dispersion-aware DFT does not extend to systems of this size, uncertainties in the benchmarks notwithstanding. For the largest systems examined here (containing up to 323 atoms), DFT errors exceed 4 kcal/mol in many cases, with considerable variation amongst different methods, even when the comparison set is limited to methods that perform very well for small noncovalent dimers. BSSE can be very large in systems of this size (∼ 50 kcal/mol or more in double-ζ basis sets), although this is handled rather easily with the standard Boys-Bernardi CP scheme, avoiding the need for triple-ζ basis sets in large systems. There has sometimes been an odd resistance to using CP correction, as detailed elsewhere, 88 but benchmark assessments provide no support for such recalcitrance.