Graphs without global-level features were used to represent DESs as single disconnected graphs composed by the corresponding HBA subgraph and the HBD subgraph. Notice that, for the vast majority of HBA species, the subgraph is in turn a disconnected graph of the corresponding anion and cation subgraphs. This single disconnected DES graph is processed using a single GNN model ignoring any intermolecular interaction information during the message-passing scheme. The message-passing scheme chosen for processing these graphs corresponds to the Graph Convolution Network (GCN) , which at each layer l, updates the graph node embedding matrix V (l+1) as