To the best of our knowledge, there exists only one example of converting raw biomass to GVL. Huang demonstrated a one-pot conversion of poplar to GVL using mixed Al2(SO4)3 and Ru/ZrO2 catalyst and a sacrificial H-donor ( i PrOH) leading to a yield of 12 wt% GVL using 800 W microwave heating to 180 °C12 . Even transforming the simpler biomass-derived uniform polysaccharides and C6-as well as C5 monosaccharides to GVL are scarcely reported . Thus, studies on developing efficient and versatile catalytic systems for the direct conversion of raw biomass to GVL is highly pertinent. Herein, we report the unprecedented direct production of GVL from several raw biomass waste materials in excellent yields up to 48%, covering three major types of carbohydrate-rich biomass sources. By using a novel combination of Ru-MACHO-BH, H2, and weak acid H3PO4(aq), the myriad of cascade steps from biomass to GVL performs highly efficiently and selectively under mild reaction conditions (Figure ). Notably, there exist relatively few examples of homogeneous catalytic hydrogenations under acidic conditions . Furthermore, the Noyori-type PNP pincer complexes , such as the Ru-MACHO complex and analogs, have demonstrated excellent activity in both basic and neutral media , but to the best of our knowledge, never under Brønsted acid conditions.