where Etot(M-Host), Etot(M) and Etot(Host) are the calculated total energies of the layered intercalation compound, the standard state of the intercalant, and the host, respectively. The unit of Eint is eV/formula unit (f.u.). Eint can be interpreted as the reaction energy between the intercalant and the host, allowing for a discussion of the stability of the interlayer compound. While a negative value of Eint does not imply that the reaction proceeds because the host is often a virtual structure, all hosts in our constructed database have been experimentally reported as a part of stable layered intercalation compounds with one or more intercalants. Therefore, if their Eint values are lower than those of the experimentally reported compounds, they could potentially be synthesized through topochemical reactions like ion exchange. Essentially, Eint enables a discussion on the relative stability of various interlayer compounds from different host and intercalant combinations.