Several studies have confirmed the amino acids and protein domains implicated in the hetero-dimer amino acid interfaces and/or A3G degradation . For instance, 127 W, 128 D, 130 D, 270 K of sA3G interactions with Vif Red 43 H, 70 W, 71 G, Y 9 , sA3G degradation-dependent 161 PPLP 22 or 40 YRHHY of Vif Red and A3G D128K mutation , viral package of A3G 124 Y, 127 W residues , etc.