The current research discovered that the aging machinery function of tau protein ingeniously connects promoters/enhancers to telomeres through transposition. The tau protein synthesises guide RNA, intercepting the transposition fragment from the telomere, thereby shortening the telomere and inducing cell senescence. At the same time, tau protein adds the transposition telomere fragment to the promoter/enhancer region, which slows down gene transcription and messes up RNA polymerase II. This lowers the number of gene copies and starts the aging process in the brain. Consequently, the transposition of telomere fragments to the promoter/enhancer region double-protects tau protein's aging machine function.