We presented a chemical reaction network that produces self-sustaining, dynamic vesicles based on simple molecules and driven by the conversion of activating agents. The reagents used in the network have been demonstrated to be prebiotically plausible, and the fueldependent vesicles could thus be used as a protocell model. In future work, we will combine these self-sustaining vesicles with catalysts, for example, catalysts that can convert prebiotic reagents into condensing agents driven by light. In day-night cycles, such vesicles could compete for resources. We will also combine the protocells with RNA sequences to test whether a pre-genotype, in the form of information-containing RNA, can influence the behavior of the protocells, for example, their ability to survive starvation periods or their ability to divide.