method by benchmarking against accurate ab initio calculations. We apply it to the S12L and L7 datasets of large organic dimers and show that the vdW interactions can displace charge by up to 80 % of the DFA-induced displacement or even exceed it, as in the case of alkane chains. We found that vdW polarization effects scale linearly with system size, highlighting their growing importance in extended molecules and materials. Accounting for vdW-induced polarization leads to striking differences in NCI isosurfaces as measured by their volume, which increases by several folds. The application of FCO-MBD to large (bio)molecules like the Fip35-WW protein allows us to identify smooth (as opposed to "patchy") interacting regions, facilitating chemical analysis of noncovalent interactions in these complex systems.