For a number of reasons, H would be the ideal nucleus for hyperpolarization-enhanced MRI : 1. Sensitivity -1 H-detection is more sensitive than, for example, C by a factor of ≈16, and N by a factor of ≈100, if they are polarized to the same degree and are at the same abundance; 2. Equipment availability -1 H probes are readily available in commercial MRI scanners; 3. Isotopic abundance -Unlike C or N MRI, there is no need for expensive isotopic enrichment of the samples; 4. Spatial resolution -Greater response to magnetic field gradients means higher spatial resolution can be obtained than for lower-𝛾 nuclei.