By comparing the simulation results to experimental data for the surface wettability of hematite by PAO4, 105 it is possible to select which potential best describes solid-liquid interactions. Various different types of molecular dynamics simulations can be used to predict the wettability of solid surfaces. For example, the contact angle can be quantified through monitoring the geometry of nanodroplets or free energy-based methods. Alternatively, molecular dynamics simulations can be used to directly quantify the work of adhesion. While we tried both nanodroplet contact angle and work of adhesion simulations, we found the latter to be the most instructive. Previously, experimental values for the work of adhesion have been used to tune the solid-liquid LJ interaction strength for graphene-water systems. The solid-liquid work of adhesion was calculated for the α-Fe 2 O 3 interface for each of the selected solid-liquid potentials. The solid-liquid potential energy, u sl , and corresponding derivative, ∂u sl ∂λ , for the weakest (ClayFF ) and strongest (Savio et al. ) are shown as a function of λ in Figure . The Coulombic and LJ components of the solid-liquid potential energy, u sl(C) and u sl(LJ) , respectively, are shown separately. We observe that, as λ is scaled towards zero, the contributions of both components tend towards zero. As the strength of the solid-liquid LJ potential was increased from ClayFF to Savio et al., the LJ contribution to the work of adhesion, W sl(LJ) , increased significantly. The Coulombic contribution, W sl(C) , was much smaller and was essentially unchanged between both solid-liquid potentials. These observations were expected since the PAO4 fluid is nonpolar and the partial charges for both solid-liquid potentials were identical. The overall work of adhesion W sl was calculated using Equation .