In the literature, the xTB methods have already been applied in multilayered frameworks. These frameworks can vary depending on the approach -whether using the subtractive ONIOM or additive QM/MM, 184 the role of GFNn-xTB as a high-level or lowlevel method, and the treatment of solvation as continuum or explicitly. The available research spans a diverse chemical space, from water clusters, 185,186 DNA-strands 187,188 -lanthanoid complexes, 189 organoflourine compounds, 190 to (metallo)proteins. In addition, there is some interesting work done on benchmarking the size of the inner region, 200 probing QM/MM interface handling, 201 and reparameterizing Lennard-Jones potentials based on the QM/MM results. The ONIOM routine is implemented in the xtb package starting from version 6.6.0. In addition to the methods available in xtb itself, it interfaces the ORCA In addition to the aforementioned four "main" publications, the database contains the review on the extended tight binding 5 and does not contain duplicates. The database was processed to assess the popularity of xtb over the years, which is shown on Fig. .