After the scaffold is formed, its gradual degradation occurs, allowing the formation of new bone forming cells. The optimal scaffold must degrade and resorb in line with the formation of new osteoblast cells otherwise this approach may fail if scaffold degrade at a faster rate than tissue regeneration . The recruited cells differentiate into mature osteoblasts under the influence of internal cues within the scaffold and signaling from surrounding tissues. The osteoblasts then replace degrading polymer and deposit new bone matrix within scaffold pores. Certain growth factors like bone morphogenic proteins (BMPs), platelet-derived growth factors and stem cells induced in scaffold promotes bone formation and healing process . Nowadays, the use of physical cues (light, magnetic signal, mechanic signal, electric signal, morphology, and heat) as short acting growth factors is enlightened instead of expensive other regulators, to achieve efficient bone regeneration 4 .