Curriculum Objectives Maintain Scaffold Exploration. Scaffold diversity was investigated by extracting and averaging the number of unique Bemis-Murcko scaffolds from the triplicate experiments, shown in Fig. . (see Supplementary Table for individual experiments). It is evident that the CL experiments generate more unique scaffolds than baseline RL. This is expected from the training plots observed in Fig. and where the baseline RL experiments generate essentially no favourable compounds in the first 100 epochs. Between the Curriculum Objectives, Tanimoto generates more unique scaffolds than ROCS. Similarly, "High" scenarios generate more unique scaffolds than "Low" scenarios for both Tanimoto and ROCS. To assess the quality of the generated scaffolds, we denote scaffolds 'favourable' if the corresponding compound possesses a more favourable docking score than the reference ligand.