We employed the domain search method to investigate the active domain of the Hantavirus protein in this work. The findings showed that Hantavirus membrane glycoprotein E comprised lipid phosphatase and C2-like domains. E was attached to the cell membrane independent of Ca 2+ via tensin phosphatase (PTEN). Dephosphorylation of PtdIns P3 by E resulted in PI(4,5)P2. The substance stimulated E's membrane binding and shedding. E's tensin phosphatase-like system affected lipid metabolism and endothelial cell remodeling in the vascular endothelium. The PTEN activity of E increased the permeability of the blood vessels and results in renal and cardiopulmonary syndromes. Hantaan and Andes had slightly different lipid phosphatase domain characteristic motifs HCXXGXXR. It may be a significant factor in the development of kidney and cardiopulmonary syndromes.