On top of the laminar flow, large surface-area-to-volume ratios of the fluids ensure thermal homogeneity across the system and rapid heat transfer between the device and the fluid. This advantage ensures uniform reaction conditions, that are particularly important in chemical and biological systems . For these reasons, scaling such systems down to nanoliter or picoliter volumes can fundamentally improve the sensitivity of conducted analysis, simultaneously limit the reagent volume, and therefore reduce final cost of the analysis.