Target analysis was performed with PHAROS () in the case of human proteins. For bacterial proteins, essentiality was predicted using Geptop 2.0. Post-hoc analysis of contingency tables were performed through a Fisher exact approach as described elsewhere, and p-values were adjusted by Benjamini-Hochberg correction; significance level was 0.05. The distribution is overwhelmingly dominated by the "Glycerolipids" and "Glycerophospholipids" classes (~4000 and ~1000 compounds each, respectively) as expected, given the large number of different structures of these molecules in the diet.