I explored several values for X, ranging from 1.2 to 3.0. With the lowest value (X = 1.2), the weight of a given toxicity measure is only 1.2 times that of the next lower priority measure (K+1), while with X = 3.0, the weight increases more steeply. Importantly, I found that the qualitative results remained consistent and robust across all X values, supporting the use of this overall toxicity measure for ranking the natural products. To account for the differing natures and units of the 11 toxicity measures, I determined the minimum and maximum values for each measure and scaled them to the [0,1] interval. It is important to note that when comparing overall toxicity scores across different datasets, the same scaling factors must be used to ensure consistency. I present the average overall toxicity values for two distinct groups: a deduplicated set of 3,191 approved drugs obtained from the FDA (USA), the European Medicines Agency (EMA), and the Pharmaceuticals and Medical Devices Agency (PMDA, Japan), and a comprehensive set of 321,420 natural products. To ensure consistent scaling, we combined both datasets when determining the global minimum and maximum for each toxicity measure.