The RDFs between neopentane and TMAO is shown in Figure . Again, a marginally higher TMAO density is found in water-urea-TMAO solution than that in water-TMAO solution. Hence upon addition of TMAO in water-urea solution a bit more accumulation of urea around neopentane is found. Similarly, an addition of urea in water-TMAO mixture, an enhanced accumulation of TMAO is found near hydrophobes.