Chemoswitchable catalysts are compounds that are responsive to the presence of external additives, such as organic or inorganic reagents. Unlike redox-switchable catalysis, chemoselective catalysis does not involve alterations to the catalyst that leads to changes in their formal oxidation state. Because chemical reagents have a wide range of properties, they can trigger molecular events via various modes of action. For example, cations can bind Lewis basic sites whereas anions can bind Lewis acidic sites. Such interactions could turn a catalyst on or off, or modulate their reaction rates. Alternatively, chemical reagents could covalently modify a catalyst to produce another active species capable of achieving orthogonal reactivity.