The experimental labs of Lyle Isaacs and Bruce Gibb conducted Isothermal Titration Calorimetry (ITC) and/or Nuclear Magnetic Resonance (NMR) spectroscopy to obtain binding measurements for SAMPL8 host-guest challenge. All experimental binding data for host-guest systems are listed in Table , shown in Figure , and in the SAMPL8 GitHub repository (see ). If there are any updates or changes to experimental data, the GitHub repository will provide the authoritative source.