The in vitro biocompatibility of the PBS and PBS-based copolymers have displayed excellent biocompatibility with a variety of different animal and human cells, such as rat osteoblast and cardiac cells, mouse fibroblast and myoblast cells, and human fibroblast and chondrocyte cells - . In fact, PBS has been found to be similarly biocompatible to PLA, which has a well-established reputation in the field of biomedicine . In contrary, the bioactivity which refers to the ability to form biomimetic hydroxyapatite (HA) on the surface is insufficient for PBS . While bioactivity was for years strictly limited to promotion of bone cells attachment, which is an essential requirement for the osseointegration , it has recently expanded to encompass a wider range of applications that are intended also for soft tissue engineering.