LY3537982 showed an energy barrier for the rotation of between ~23 and ~26 kcal/mol, which is lower than predicted for GDC-6036. These values suggest that LY3537982 would belong to the Class 2 atropisomers with a delayed interconversion (days), for which development as mixtures is recommended . Interestingly, with LY3537982 there is a difference of 1.45 kcal/mol between the energy minima of its atropisomers, where the putatively bioactive atropisomer has a lower energy minimum. This would suggest that there is a preference for the putatively biologically active atropisomer in the equilibrium.