As a result, it is possible to tune the uptake and delivery of guest molecules by appropriate selection of the MOF scaffold. This chemical control provides a potential way to design carrier materials for programmed release of multiple active ingredients occurring upon certain physical (light, temperature, humidity) or chemical stimuli (pH, chelating agents). Particular examples in the field of food safety include the encapsulation of eugenol in a PUM168 single crystal or the triggered release of allyl isothiocyanate. Among the possible MOFs to be used as encapsulating agents in food related applications, the mesoporous iron(III) trimesate nanoMOF MIL-100(Fe) offers unique possibilities since is biocompatible and can be produced through green synthesis in optimal scales. In addition, the structure characteristics of MIL-100(Fe) permit to form accessible coordinatively unsaturated iron sites upon induced reducibility on the framework, strongly modifying the preferred interactions with guest molecules. Moreover, the nano-structuration of the framework improves its chemical and colloidal stability, thus facilitating the processing of the material for immediate applications like its integration in films. In this work, a composite material based on a phenolic compound, carvacrol, loaded into nanoMIL-100(Fe) is obtained. Carvacrol is an aromatic monoterpene present in the essential oil extracted mostly from oregano which exhibits antimicrobial properties. The MOF scaffold not only stabilizes and protects the active molecule, but also promotes a prolonged release when supported in polymeric films (Figure ), resulting in a stable antimicrobial effect largely desired in food industry.