The CBD formulations followed a somewhat similar pattern like CXB formulations, i.e. minor loss in solubility (< 5%) was observed at day 1 at all the tested ratios and until day 30 no significant loss was further observed (Figure ). However, in freshly prepared formulations, the solubility of CBD never exceeded 1.5 and 3.4 g/L in POx and POzi based triblock copolymers, respectively.