In the present study we therefore assessed the ability to use the SMx universal solvent models to predict limiting activity coefficients. We considered 148 molecules for which SMx (solvent) parameters were available in QChem 5.1.2. As seen in eq. 4 the calculation of limiting activity coefficients is dependent upon both the self-solvation free energy (∆G self i,i ) and solvation free energy terms (∆G solv i,j ). Therefore we assessed the contribution of each individual term. The Minnesota Solvation Database was used as our reference set, since it was used to parameterize the SM12 model, which was consistently the top performer throughout the analysis.