Interstitial fluid (ISF) processes a similar composition profile as the blood due to its capability to exchange substances between the cells and the blood by diffusion , making it a valuable candidate for glucose monitoring . Despite promising, obtaining ISF is still challenged by miniscule volumes available in the dermis (120 μl/cm 2 ) and the filtration effect caused by the applied force, leading to slow extraction rates for continuous sampling . Microneedles (MNs) have been used for drug delivery and transdermal extraction . The length of the MNs is generally between 100 to 1000 μm, which can guarantee that microneedles can puncture the stratum corneum without stimulating the nerves and vessels in the dermis for painless and minimally invasive effects . Hollow microneedles (HMNs) have been reported to sample ISF via epidermis piercing and capillary force for glucose monitoring . To date, the combination of micropores and suction approach has improved the collection rate over sole needle-based extraction and reduced tissue damage caused by suction blisters .