To address this issue, in this work, we used enzymes that have emerged as a compelling alternative catalyst derived from natural resources. Among enzymes, Candida antarctica lipase B (CAL-B) stands out due to its stability and high reactivity, with its unique structure enabling high regio-, enantio-, stereoselectivity, and the ability to function under mild reaction conditions . As confirmed in previous studies, enzymatic catalysis results in a more regular structure in copolyesters compared to metal-catalyzed processes . This feature opens up opportunities to obtain optically pure materials with well-defined chemical structures, particularly valuable in the pharmaceutical industry. CAL-B-induced polymerization has already been successfully applied to various polymer types, including polyesters based on 2,5bis(hydroxymethyl)furan, vegetable oils, sugars, and 3,6-dianhydrohexitol .