Exocytosis is a key mechanism used by eukaryotic cells to release biological compounds and to transport molecules across the plasma membrane. As a response to physiological signals, specialized secretory cells undergo regulated exocytosis. In particular, sperm exocytosis (or acrosome reaction) is a regulated secretion required to fertilize the egg that depends on large bilayer remodeling, such as membrane bending and fusion. During this unique process, multiple fusion pores form between the acrosomal and plasma membranes, connecting the lumen of the acrosome to the extracellular milieu. Accurate molecular mechanisms that describe membrane fusion and the formation of the fusion pore have been objects of research among the experimental 8,9 and computational 10-13 sciences.