The results presented here for a given small molecule binder can be calculated in minutes to several hours, depending on the number of independent docking jobs, number of available cpu, and complexity of the ligand and protein. It is certainly much faster than generating a 1 microsecond molecular dynamics trajectory of a protein-ligand complex with 500,000,000 frames at 2 fs apart. Efficiency increase is estimated at x1000 or more. The calculations and making succinct reports can be automated, and due both to the efficiency and detailed information coming from it, the approach is suited to implement in a large screening of molecules.