The area per lipid in the extracellular leaflet is smaller than in the cytoplasmic leaflet due to the higher proportion of saturated phospholipids as was the case in the Martini 2 model. The membrane thickness, calculated as the phosphate-to-phosphate distance, is found to be higher with the Martini 3 model (4.22±0.01 vs 3.94±0.02 nm).