The crystallization of 1,1'-Bi-2-naphthol (BINOL) with (1R, 2R)diaminocyclohexane was selected as a model system to explore the concept of a formal DKR enabled by continuous flow (Figure ). A mixture of BINOL and toluene was heated to 80 °C in a flask and diamine 4 was added. R-BINOL crystallized as a salt from the homogenous solution on cooling to 20 °C. After 1 hr, a 20 µm stainless steel HPLC filter was inserted into the flask and mother liquor was pumped from the flask at 3 mL/min into a stainless steel plug-flow reactor (PFR) heated to 200 °C and pressurized to 250 psi to racemize the feed which was enriched with S-BINOL. Prior to entering the flash epimerization unit, the ee of stream was -95.8% (97.9:2.1 S:R-BINOL) and after exiting, the R-BINOL content was increased from 2.1% to 5.5%. The eluent flowed back into the flask to crystallize the regenerated R-BINOL. The system operated for 30 hr at which point the solids were filtered and rinsed with toluene. Even this slight increase in the R-isomer during flash epimerization was sufficient to drive the equilibrium, Figure : Continuous-SPACEDKR of BINOL via flash epimerization. and 7.88 g of solids were collected, which was a 1:1:1 inclusion complex of R-BINOL, 4, and toluene. The 80% yield of BINOL with high optical activity confirmed the concept that continuous flow can enable DKR of atropisomers.