Following ultrasonication the solution is then centrifuged at 9000 rpm for 20-30 minutes. After which the separated Curcumin nanoparticles are collected. These particles can be further freeze dried to convert the liquid nanosuspension into dry powder, ensuring improved stability and storage property. The Wet Milling process is scalable and suitable for industrial applications. The combination of stabilizers and freeze drying ensures long term stability of the Curcumin nanoparticles. However, the stabilizers need to be carefully tailored to avoid toxicity and interference with drug's therapeutic activity . Schematic diagram for preparation of curcumin nanoparticle by Wet Milling Method is shown in figure .