A solution method was introduced recently: a Gaussian Process (GP) model is trained on the net volume of acid (-) or base (+) added . Efficiency of this target optimisation method was ensured by including the a priori known shape of a titration curve, which is chemistry-specific to the sample to be titrated, into the GP via artificial datapoints (taking a point each with lower pH and more acid and the vice versa for base, relative to the initial datapoints). The convention followed is that the addition of acid is negative and base positive. The same convention is used in this study. While this solution is effective in titration of unknown formulations with hydrochloric acid (HCl) and sodium hydroxide (NaOH), this limits the published method to systems that do not generate buffers upon titration.