In contrast, when disassembly of the precursor is slow, the molecules remain trapped in the assembled state and can reactivate before disassembly. Such a situation results in chemically fueled self-assembly without the dynamics of assembly and disassembly. It is to a much lesser degree, regulated by the kinetics of the reaction cycle (Scheme 1C). In other words, the exciting properties of chemically fueled self-assembly are lost when disassembly is slow. To design molecules that are rapidly disassembling after deactivation remains a challenge because the mechanisms of kinetic trapping are poorly understood.