While the distance to the target space (MEGx) continuously decreased with the number of epochs, the distance to the source space (ChEMBL24) remained initially stable but increased after the fifth epoch. The Fsp 3 distribution of the sampled molecules (Fig. ) after the last transfer learning epoch (epoch 40) reflects the distributions of both the transfer learning set and the whole MEGx collection. This result suggests that pronounced structural diversity of the transfer learning set permits sampling of molecules with structural characteristics covering a representative portion of the target space (Fig. ). In contrast, transfer learning with five similar molecules resulted in the generation of molecules exclusively with characteristics of the transfer learning set (Fig. ). UMAP visualization indicates that many molecules were sampled from areas in the vicinity of the natural products 6-9. Overall, the compound distribution at epoch 40 corroborates extended coverage of chemical space with de novo generated molecules.