Refinement via MD simulations was carried out with the original initial model and the alternative models generated via hybridization. For each initial model, five trajectories of MD simulations were performed for 100 ns with restraints with respect to each initial model, and a refined model was generated via post-sampling processes. In addition to the refined models for each initial model, another refined model was obtained by aggregating all the sampled conformation from the original initial model and the alternative initial models.