The four false negatives that result from errors in the GFN2-xTB reaction energies and estimated barrier height (R2514, R3725, R4612, and R9011) all contain a N-N triple bond in the products, indicating a systematic error in the GFN2-xTB method. In the case of reaction energies such errors can be efficiently corrected by, for example, the connectivity-based hierarchy method. Another option is simply to use DFT instead of GFN2-xTB for the subsequent screening. The meta-MD approach produces between 1 and 51 reactions per reactant (Figure ) which is practical to check with DFT, and certainly with DFT//GFN2-xTB single point calculations. In our current approach 1257 and 2392 reactions are eliminated based on semiempirical reaction energies and estimated barriers, respectively, so that only 316 reactions are checked with DFT out of a total of 3965 candidate reactions.