Because of the sequential nature of the RASPA software, we used GROMACS to perform MD simulations in the (N, P, T ) ensemble to determine the density of systems with the same composition but four times bigger (600 particles) than those presented in Table . From these simulations, we extracted the average density and deduced the volume of the fixed cubic box to perform MC simulations in RASPA and calculate ∆µ CnAm (P ) and µ CnAm water (P ) as explained above. The raw data presenting the relationship between applied pressure and density in electrolyte solution is given in Supporting Information.