With advancements in genetic technologies, particularly gene editing, the landscape of ART is evolving to address not only infertility but also the prevention of genetic diseases. Gene editing in ART holds the promise of reducing heritable disorders, improving embryo selection, and enhancing reproductive success rates. It allows precise editing of genes in embryos, eggs, or sperm. The CRISPR-Cas9 system is the most prominent tool in gene editing , enabling precise modifications in the genome. By targeting specific DNA sequences, CRISPR-Cas9 can add, delete, or alter genes, making it a valuable technology in addressing inherited genetic disorders in embryos created via in vitro fertilization (IVF). Gene editing can correct mutations in embryos associated with hereditary diseases such as cystic fibrosis, sickle cell anemia, and Huntington's disease, preventing their transmission to future generations. Another line of application of gene editing in ART is for enhancement of embryo selectiongenetic screening combined with editing can improve embryo quality by selecting embryos with the highest potential for successful implantation and development. Gene editing can help also addressing infertilityit may help identify and correct genetic causes of infertility, such as chromosomal abnormalities or mutations affecting gamete function.