Looking at only two attributes at a time is not an efficient way to infer the relationship between all the geometrical properties of MOFs and the probability to collapse during the activation. Dimensionality reduction is one way to wrap the effects of all the geometrical properties and project them into a 2D map. Therefore, principal component analysis (PCA) was used to shrink multiple features into only two features, called the principal components. As shown in the 2D Map in Figure , the collapsed MOFs are located at the edges of the scattered data, but still there is no clear reliable correlation between the geometric properties and collapse. On the other hand, the strength of the framework should in principle correlate with its likelihood to survive the activation process. The more robust the framework, the easier to remove the entrapped solvent without any permanent structural changes. As such, the mechanical properties (i.e. bulk, shear, and Young's moduli) of the MOFs were computed via molecular simulations. The upper and lower bounds of the moduli for each MOFs were evaluated using the Voigt and Reuss methods, respectively. Consequently, the average of these limits was calculated, what is commonly referred as the Hill approach. In Figure .c,d, the average moduli were presented in scatter and smoothed histogram plots, and the activation status was marked to indicate the activated and collapsed MOFs. The probability distributions of the mechanical properties estimated using different methods are shown in Figure . The results support the general belief that the collapsed MOFs are weaker (i.e. possess small moduli) than the activated structures. Overall, the mechanical properties were superior in distinguishing the collapsed structures from the successfully activated ones. Hence, the collapsed MOFs were clustered in one region. Though, there are some MOFs with somehow good mechanical strength, yet they were reported to collapse during activation. Also, principal component analysis (PCA) was used to reduce the dimensionality of the mechanical features, and project them neatly in a 2D map (Figure ). In addition to the elastic mechanical properties, Born's stability criteria, can be used to judge the stability of the empty frameworks. The results for this analysis are provided in the Supporting Information (section 7).