In addition to the free energy maps of Figure , we also present their difference, G TIP3P - . Small shifts towards larger values of the end-to-end distance were obtained with the mass-scaled TIP3P-F model. However, the magnitude of changes in the mass of the water molecule. It is also important to note that Kolmogorov-Smirnov values from the simulations with the TIP3P-F model tend to be smaller than those observed between trajectories simulated with the standard TIP3P model. This means that the more efficient sampling by using the TIP3P-F model also results in less variability when comparing trajectories from independent molecular dynamics runs.