Here, we characterize the use of a commercial BPM for separating the anodic oxidation of a model crude glycerol solution from a generalizable, fuel-forming reduction reaction in an independent catholyte. BPMs have been used to separate disparate environments for water electrolysis half-cells. We show that a BPM can also be used for separating the GEOR electrolyte from a variety of critical fuel-forming reactions, including the hydrogen evolution reaction (HER) in acid, HER in model seawater, and for CO2RR in a bicarbonate buffer. In every case tested, the overall cell potential was reduced by roughly 1V compared to the same cathode paired with an OER anode. We show that the operating point of these systems can be predicted from a load-line analysis of independent three-electrode measurements when the turn-on potential drop across the BPM is considered in the series load. This allows for the coordination of optimized half-cell reactions for the overall design of GEOR-assisted electrolysis and photoelectrochemical systems. Finally, we show that the combination of a GEOR anode and BPM separator can sustain the nearly 1V reduction in cell potentials for extended periods (>20 hours) in quiescent solutions with minimal glycerol crossover.