In conclusion, we have implemented multi-objective BO in the discovery of Styrene-Myrcene-DBI terpolymers, for maximizing 𝑇 𝑔 while minimizing Styrene incorporation, demonstrating a framework for the design and synthesis of terpolymers with tailored properties. We report synthesized terpolymers with a wide range of glass transition temperature from -53.4 °C to 45.9 °C, and styrene incorporation varying from 0.9 mol% to 84.7 mol%. Notably, we were able to produce terpolymers with a styrene incorporation below 50 mol% with a glass transition temperature (𝑇 𝑔 ) of 24.6 °C. While this falls within the ambient temperature range, we did not achieve 𝑇 𝑔 exceeding 50 °C for wider applications. This limitation arises from the intrinsic physical properties of the monomers and their linkages, which are beyond the control of any optimization process. To overcome this challenge, it is necessary to expand the chemical search space beyond styrene, myrcene and DBI to other monomer systems and potentially leverage information from molecular simulations effectively. The 89 terpolymer samples also allowed for the calculation of ternary reactivity ratios, which would be useful information for the study of related terpolymer systems. Our platform shows that multi-objective optimization is an efficient way to drive sustainable polymer synthesis towards desired target properties, while simultaneously providing rich data to understand reaction kinetics.