Larger DW-BEL libraries could be generated by additional runs and/or adding alternative co-evolutionary fitting criteria, and/or to adapt to other possible parent interactions maintaining any of their substructures (lazo variability). Some of the DW algorithms ready to use in DW-BEL, presently include not only Docking score, Molecular weight, Hydrophobicity, and Toxicity Risk but also Basic nitrogen counts, Acidic oxygen counts, Ring count, Structural (dis)similarity, Conformers similarity, Molecular flexibility, Molecular complexity, Molecular shape, and other. Inclusion of any new DW criteria may be requested into the DW forum ().