These results offer an approach for designing and fabricating artificial cells or protocells with more complex structures and functions based on the VPS processes of DNA coacervates. In addition, Figure shows that the extracted DNA microcapsules shrank while maintaining their shape similarity under osmotic pressure. This stimulus responsivity enables the development of molecular-responsive systems with DNA aptamers and molecularmechanical systems with DNA actuators . In addition, DNA molecular devices capable of molecular computing using DNA logic gates can be implemented in our DNA microcapsules. This study is believed to provide a new approach for developing dynamic capsule structures for artificial cells and molecular robotics .