In this study, the photocatalyst degradation of ciprofloxacin antibiotic has been carried out by using three tri-doped photocatalysts i.e., B1Ce1Ag0.1TiO2, B1Ce0.1Ag0.06TiO2, and B1Ce1Ag0.06 TiO2. The photocatalytic degradation capability of B1Ce1Ag0.1 was comparatively higher than the remaining two doped catalysts, as it degraded 54% in 120 min. These results concluded that B1Ce1Ag0.1TiO2 was the best performing tri-doped photocatalyst. The performance of the tri-doped catalysts under UV-A irradiation was not encouraging and these catalysts need to be tested under visible or sun light for obtaining better results. Further work is needed to check the effectiveness of the catalyst in large scale. This study focused on evaluating the photocatalytic degradation of ciprofloxacin, a commonly used antibiotic, using three tri-doped titanium dioxide (TiO₂) photocatalysts: B1Ce1Ag0.1TiO₂, B1Ce0.1Ag0.06TiO₂, and B1Ce1Ag0.06TiO₂. Among the three catalysts synthesized, B1Ce1Ag0.1TiO₂ demonstrated the highest photocatalytic activity, achieving a degradation efficiency of 54% within 120 minutes under UV-A irradiation. This result highlights the potential of tri-doping with boron, cerium, and silver in enhancing the photocatalytic performance of TiO₂. However, the overall performance under UV-A light was moderate, indicating the need for further optimization and testing under broader light spectra, particularly visible or sunlight, to harness the full potential of these materials.