In the next step, the bromide anion was exchanged for the natural anion of a proteinogenic amino acid: L-asparagine or L-alanine. The bromide anion is characterized by limited acute toxicity , however, in elevated concentrations it exhibits neurotoxic effects , and also affects iodine metabolism in the body . According to the 4th principle of green chemistry ("Designing safer chemicals"), it is reasonable to replace it with anions characterized by the absence of toxic effects on the human body . To incorporate the amino acid anion into quinine-based QASs, the previously described method of converting 1-alkylquininium or 1-(2-hydroxyethyl)quininium bromides into the corresponding quaternary ammonium hydroxides using anionic ion exchange resin in ethanol of natural origin was used. The resulting hydroxides were then neutralized with the appropriate anion source to yield the desired products and water . The method is sustainable and conforms to the principles of green chemistry, and its main advantages include low energy input (the process is conducted at atmospheric pressure at room temperature), very high yields (>99%), no contamination of the final product with halides, and the use of safe reaction media that can be easily regenerated and reused. The only by-products are the water formed during neutralization (Scheme 1) and the inorganic salt with a bromide anion obtained after regeneration of the ion exchange resin.