In spite of various models developed for drug discovery, but most therapeutic drugs still fail in clinical tests and one of the reasons is attributed to sufficient clinical predictive power of our current model systems. usually, for a drug discovery research in the laboratory, in combination with the chemical examinations, cell-based and in vivo testing would perform more efficiently to obtain effective lead compounds for other drug development, although the high genetic similarities between human and mice, physiological differences affect the course of disorder in mice models when some genetic disorders in human do not have the same symptoms in mice.