Figure shows a classification of the 471 compounds associated with DILI according to the type of chemical taxonomy. The analysis shows that major types of compounds exhibit around 10% of chemical structures associated with DILI events. However, organohalogens, phenylpropanoids, polyketides, organic acids, organosulfur, alkaloids, and organophosphorus compounds exhibit a rate higher than 10% of associated DILI compounds. Additionally, the most frequent compounds associated with DILI events contain complex ring systems, specific functional groups, and atoms (e.g., double carbon bonds, carboxylic acids, ketones, halogens, sulfur, phosphorus) that per se have been associated with hepatic injuries . From a chemical perspective, these observations could lead to the early identification of compounds potentially associated with DILI events.