During the last years small molecular weight drug-like compounds have been rarely proposed to treat rhabdovirus outbreaks on farmed fish (except those for IHNV vaccine prevention or SVCV natural products. Most probably, the risk of introducing toxicities on the aqueous environment could explain some of these delays. To computationally prevent those potential toxicity problems, the generated conformers were selected during and after their co-evolution to eliminate hundreds of known toxicities. However, on due time to further reduce the probability of environmental risks, experimental evidences would be needed. In the meanwhile, basic research on VHSV infection / fusion could benefit from the experimentation with some of these or similarly generated conformers.