Glycerol is well-understood as a sacrificial electrooxidation substrate for replacing water oxidation in anodic reactions. GEOR occurs at lower positive potentials on the anode than for water oxidation in both acidic or basic electrolytes and results in a variety of products such as glyceraldehyde, dihydroxyacetone, and a variety of organic acids. It has been shown that a mixed metal electrocatalyst composed of Au, Pt, and Bi is capable of achieving cell potentials of less than 600 mV for sustained GEOR-assisted hydrogen evolution in a model crude glycerol solution. The low cell potentials are attributed to the reaction being limited to the two-electron oxidation of glycerol to dihydroxyacetone or glyceraldehyde. Based on Gibbs free energies of formation, the thermodynamic oxidation potentials for glycerol to dihydroxyacetone or to glyceraldehyde were estimated to be 0.05 V and 0.19 V vs. RHE, respectively. More positive anode potentials, and hence higher overall cell potentials, were required to oxidize either glyceraldehyde or dihydroxyacetone further. Hydrogen was separated from the anode by a ceramic anion exchange membrane, which constrained the HER electrocatalysis to the same alkaline electrolyte conditions as in the anolyte. This is not necessarily an ideal electrochemical environment for hydrogen evolution. More generally, it limits the practicality of the GEORderived cell voltage saving combination with other fuel-forming cathodic reactions such as seawater electrolysis, CO2 reduction, or photoelectrochemical (PEC) devices driving these reactions. Bipolar membranes (BPMs) are layered structures composed of an anion exchange and a cation (or proton) exchange layer. Water dissociation between these layers, either natural or catalyzed by metal oxide particles, provides hydronium to the catholyte and hydroxide to the anolyte, respectively. This effectively enables optimized, yet disparate electrolytic halfreactions to communicate electrochemically.