As the infrastructure of the Chemotion repository is already in place to publish data and metadata of samples as a main data entity also including the generation of DOIs, the research data repository is used in the herein described concept for the generation of the virtual sample representation to make physical samples findable. Both systems have to exchange information via a defined protocol to enable the additional matching of samples' virtual representation with the content of the Molecule Archive. This protocol checks if sample representations in the Chemotion repository match registered samples in the Molecule Archive (Figure