This study provides a physical blueprint for molecular machine-containing frameworks poised as new devices by which external stimuli can act to provide activated diffusion for directional mass transport or nanoscale microfluidic devices, mimicking biological systems. The introduction of MMs into the backbone of periodic framework materials has yielded stimuliresponsive assemblies of controlled dynamics in the solid-state. Although this specially defined arrangement of MMs in the solid-state represents dynamic heterogeneous interfaces, the collective synchronized work of MMs in the solid-state is unprecedented and molecular simulations, like that presented here, provide essential insight for experimental endeavours.