3. Selective immune modulation. Unlike broad immunosuppressant drugs, inverse vaccines can selectively target and suppress only the specific T cells involved in the autoimmune attack, leaving the rest of the immune system intact. This more targeted approach has the potential to avoid the side effects of general immune suppression, like increased infection risk. 18 4. Inducing durable immune tolerance. By resetting the immune system memory and tolerance of the target self-antigen, the inverse vaccine approach aims to provide long-lasting protection against the autoimmune attack, potentially offering a more durable treatment compared to chronic immunosuppressant drugs. In summary, the key innovation behind inverse vaccines is their ability to selectively remove the memory of the immune system for specific self-antigens by hijacking natural toleranceteaching mechanisms of the liver, rather than broadly suppressing the entire immune system.