On our testing machine, Ringtail achieved a throughput of up to ∼22,000 compressed DLG files/minute written to the database. Tests show that the runtime appeared to scale linearly with the number of files being to be processed and written the database, then depending mainly on the storage I/O throughput and the number of CPUs/cores available on the system used. The SQLite format is limited by the maximum size of the database file (281Tb). We estimate this upper-bound limit would still allow users to store docking results of tens of billions of ligands, while larger libraries could still be accommodated by distributing results across multiple SQLite database files.