Many aldehydes are commercially available and inexpensive. It is also possible to functionalize these secondary amines using ketones, 37 carboxylic acid or halide derivatives (via Buchwald-Hartwig coupling). Only chemical groups sensitive to boron trichloride need to be avoided or protected beforehand. The strategy allows the insertion of various substituents on the scaffold's structure, opening new avenues for searching for anti-Chagas drug- candidates. Specifically, new insights have been gained concerning the essential pharmacophoric elements present on the molecule's scaffold (Figure ). The upcoming challenge will be to test the cyclopropyl derivative 11b in the long-term amastigote recrudescence assay for sterile cidality described by Cal et al.,