In patients with hypoxia, this study discovered that cholesterol-dependent cytolysin activated its hemolysis function. According to some studies on the "oxygen dissociation curve problem," COVID-19 patients exhibit no obvious signs of hypoxia or hemolysis. It indicated that specific SARS-CoV-2 proteins contained cholesterol-dependent cytolysins. Their hemolytic activity was also related to the availability of oxygen. In hypoxia, it induced hemolysis. Calcium ions are involved in the process of red blood cell invasion. Calcium ion is a factor in blood clotting. As a result, viral proteins may not cause a significant hemolytic reaction when they enter the red blood cell membrane. This study discovered that the viral proteins S and ORF3a contain a 4.1m domain that binds to 4.1 protein in the red blood cell membrane. 4.1m domains are also found in neurexins, syndecans, and glycophorin C. Syndecan-4 is a heparan sulfate-containing transmembrane proteoglycan. It functions as a co-receptor for cell adhesion with integrin. As a result, the SARS-CoV-2 protein can also adhere to the red blood cell membrane via the heparin system. Glycophorin C (GPC) and Glycophorin D (GPD) both express antigens from the Gerbich blood group system . Generally, Gerbich antibodies do not result in severe hemolytic reactions. As a result, some researchers believe that excessive interpretation of the oxygen dissociation curve is inappropriate(114). If the oxygen dissociation curve is used exclusively in medical diagnosis, it may result in an error. It is worth noting that our discovered malaria had comparable hemolysis and oxygen supply issues.