Several approaches have been used to achieve a coarse-grained representation of VSOMM models. Dissipative particle dynamics was used to simulate models from the initial version of the Modeler 51 . Recently, Xue et al. used the Martini force field to convert a set of HS molecules from the VSOMM2 into a coarsegrained representation. They investigated the dynamics and interactions of the molecules with lipids, peptides, carbohydrates, and lignin. We have developed a coarse-grained VSOMM2 model by utilizing the recently released Martini 3 version 53 , by coarse-graining the entire fragment database . This enabled the generation and investigation of different HS structures based on a general conversion scheme.