Microcrystal electron diffraction (MicroED), also referred to as three-dimensional electron diffraction (3DED) is sought out for its ability to interrogate a variety of micro-scale or nano-scale crystallites , including proteins , peptides , small molecules and materials . One key to the success of MicroED has been its adoption of existing crystallographic approaches and cryoEM instrumentation for the determination of atomic structures . Over the past decade, the typical MicroED experiment has relied on the use of a transmission electron microscope (TEM) equipped with an electron source operating at 200-300keV and fitted with a scintillator-based pixelated detector. In this way, TEMs have been, without much alteration, readily adaptable to MicroED experiments at room temperature or under cryogenic conditions . MicroED has also benefitted from the robustness of crystallographic theory and its application, broadly adopting the implementation of crystallographic data reduction and refinement software .