The DC-SCAN+D3 and DC-SCAN0+D3 methods work reasonably well for conformers and polymorphs of the benchmark ROY and molecule X systems, although the larger molecule axitinib proves to be more difficult. For axitinib, most (but not all) of the DC-DFT approaches improve upon their conventional self-consistent analogues, but none of the DFT methods produces fully satisfactory agreement with CCSD(T) benchmarks. We speculate that the relevant π-delocalization error in this case may be isolated within a particular aromatic moiety, and that DC-DFT applied to the entire (much larger) molecule may upset the balance of reasons why particular functionals perform well for the parts of the molecule that do not suffer from over-delocalization of π electrons. A fragmentation strategy might help, with DC-DFT applied only to part of the molecule, but in any case this system highlights potential difficulties in applying DC-DFT to systems where SIE problems are confined to a relatively small portion of a much larger molecule. Overall, our results underscore previous work indicating that monomer-corrected periodic GGA calculations, with an appropriately selected level of theory for the monomer corrections, is an effective and low-cost strategy for polymorphic molecular crystals.