22, 23 15, 16, 24, 25 are actually being developed to overcome some of those difficulties . Those ligands were identified by testing a series of drug-like derivatives (heterorings to reduce LogP, minimal numbers of rotatable bonds, introduction of potential hydrogen donors/acceptors, etc) and addition of pro-drug fragments to their molecular backbones. Iterative designed FtsZ benzamide-based derivatives monitored by fluorescent FtsZ binding assays, identified some related chemotypes that showed similar binding concentration than PC190723. Similarly, many other small molecule inhibitors targeting idc have been reported