Typically, there were used 1.25 equivalents of dendron per carboxylic acid moiety. The deprotection reactions were confirmed using 1 H-NMR and no further purification was done prior to coupling to the core unit. The BOC groups and t-butyl esters were removed by dissolving the compound in CH2Cl2 (10 mL/g) followed by addition of Trifluoroacetic acid (5 mL/g). This was stirred for 2 -3 hours followed by removal of the volatile compounds. The product was dried first in vacuo and then using a stream of N2. The Z groups and benzyl esters were removed using catalytic hydrogenation at 4 bar pressure (H2) using Pd/C (10% on C, 0.10 g/g) and EtOH (96% or abs., about 15 mL/g) as solvent in a Parr shaker. The typical reaction time was about 15 h. The reaction mixture was filtered through a plug of celite on a glass filter funnel with suction and concentrated in vacuo. If the product was contaminated with residual Pd/C it was dissolved in CH2Cl2 (about 15 mL/g), filtered again using gravity filtration and concentrated in vacuo. The PyBOP couplings were done by dissolving each of the deprotected compounds (dendron and core) in CH2Cl2 (10 mL/g) followed by adding Triethylamine to basic reaction on pH paper. The PyBOP (1.25 eq/acid moiety) was added the core followed by addition of the dendron solution. The resulting solution was added 4-N,N-Dimethylaminopyridine (10 mol%) and the reaction stirred for seven days. The volatile components were removed in vacuo and the product taken up in EtOAc (15 mL/g) and added water followed by vigorous stirring for several hours. The layers were separated and the organic phase washed with K2CO3 (aq) (10 %, 4 × 30 mL/g), NaHCO3 (aq) (10%, 5 × 30 mL/g), water (5 × 30 mL/g) and finally brine (2 × 30 mL/g). The organic phase was dried (Na2SO4), filtered and the product concentrated in vacuo to give the product. The visual appearance of the product was light brown clear thick syrup. If the product was contaminated with amino-terminated Dendron (checked with 1 % Ninhydrine in EtOH), it was dissolved in CH2Cl2 and treated with polystyrene carboxylic acid chloride (see supplementary material) followed by filtration and evaporation.