1. Two benchmark studies utilizing OpenAI, Meta, and Nvidia LLMs provided high quality solutions to 10 cancer drug synthesis direct prompts, as judged by two LLM judges . Responses regarding better, faster, and less expensive methotrexate synthesis; and paclitaxel synthesis from simple starting materials earned top model Nemotron 4 average prompt scores of 9.2/10 and 9.2/10 by ChatGPT-4o and L3.0-70B .