performing CEC reactions in a medicinal chemistry setting compared to existing methodology. (i) Experimental setup is straightforward because all reactions utilize the same reaction components under the same reaction conditions. In contrast, conventional CEC protocols operate within an almost indeterminate optimization space as various reaction parameters, such as ancillary ligand, solvent, and inscrutable additives, are all typically individually optimized for each substrate. (ii) It is compatible with a wide range of solvents, including green solvents (see SI), which assists in finding conditions where substrates are fully soluble and reduces environmental impact. (iii) It utilizes a homogeneous reductant as opposed to a heterogeneous reductant, which is important for scale-up.