We studied the SARS-CoV-2 virus proteins using the domain search method. This current study discovered that ORF3a, S, and N viruses and others had more extended Autotransporter domains. The SARS-CoV-2 virus proteins S and ORF3a invaded immature red blood cells like Plasmodium falciparum using Plasmodium falciparum-like antigen or complement C1q. Through perforated holes in the oxygen-sensitive hemolysin, the SARS-CoV-2 virus protein ORF3a, S entered the red blood cells. Both invasion conditions resulted in red blood cell dysfunction.