Further, we added an aqueous buffer as control and unrelated miRNAs, m3 and m4, to the RNA droplets to confirm that no unspecific reactions would occur. The initial phase state showed no significant change (Figure , Movies S4, S5), suggesting that the computational RNA droplets can function in a sequence-specific manner. In summary, our RNA droplets can perform AND logic operations using programmable phase behavior. The component sensing motif was designed to comprise six ssRNAs hybridized in the stem regions. This multi-stranded nature gave us beneficial flexibility in designing the motif restructuring as the basis of programmable phase behavior. The specialized roles among multiple strands could integrate two opposing machinery into one motif, where one facilitates the self-assembly of the building blocks into network-like structures, and the other can abolish the network when activated upon inputs of (1, 1). This multi-strand design strategy gave us significant flexibility in the bottom-up programming of phase behavior.