ChemPer is more efficient than SMIRKY. SMIRKY used a Monte Carlo algorithm starting with a single generic SMIRKS pattern, and the search resulted in a combinatorial explosion and associated sampling problems. As discussed in Section 2, there are many advantages to taking a more deterministic approach in ChemPer. In addition, SMIRKY required upwards of 100,000 iterations to be useful. ChemPer can create the high specific SMIRKS immediately and required around 5,000 iterations for generalization using the Reducer. This more efficient algorithm will make it a more practical combination with other force field parameterization tools.