We explored the correlations between the age-related diseases and the anti-aging strategies as reflected in the number of documents in the CAS Content Collection (Figure ). Generally, metabolic manipulations, physical exercise, hormonal replacement, dietary supplementation, as well as stem cell therapies, appear as well exploited approaches against multiple pathologies. Stem cell transplants are procedures, which restore the hematopoietic stem cells in patients receiving high doses of chemotherapy or radiotherapy used to treat certain cancers. Stem cell transplants do not typically work against cancer directly; they rather help recover body's ability to produce stem cells after such high-dose interventions. Still, in multiple myeloma and some leukemias, a stem cell transplant may work against cancer directly, due to the graft-versus-tumor effect taking place after allogeneic transplants, when leukocytes from the donor attack the remained cancer cells after high-dose treatments. This effect enhances the success of the treatments. Growing evidence is also indicating that cancer stem cells can differentiate into various cell types, including noncancerous cells. Scientists are taking advantage of this observation through a treatment called differentiation therapy. • Metabolic manipulation approach is well correlated with virtually all age-associated diseases, but specifically with diabetes and obesity.