U,W ⊕C (z), due to the introduction of the C12E6 monolayer into the AWI (see the discussion on Eq. 25). Also shown are the energetic and entropic components of the synergistic effect, ∆C EU,W ⊕C (z), and -T ∆C SU,W ⊕C (z), respectively. Panels a, b, and c show the synergistic effect for solutes, U =DS -, U =DS 0 , and U =SO4CH - 2 , respectively. The vertical lines show the z-values of the DS -free energy minima for each system (DS -binding to the AWI and to the ACWI).