A recent study reported that a 37-year-old woman was diagnosed with cerebral venous thrombosis and splanchnic thrombosis after eight days of receiving the coronavirus vaccine dose. Even after getting treated, the problems increased and she was diagnosed with therapeutic plasma exchange (TPE). Within 2 years, the woman was diagnosed with a severe epileptic and neurological condition. Upon her serum analysis, it was confirmed that there was an alteration in her autoantibodies against several GPCRs and also against RAS-related proteins which caused two more TPEs. This led to further clinical improvement which highlighted the role of GPCR autoantibodies in the responses to vaccines for Covid-19 . Moreover, some rare cardiovascular and high blood pressure (which were rarely recorded) issues have been reported in some cases after mass vaccination which made the safety of these vaccines questionable. Researchers have suggested that these vaccines have been associated with risks of several cardiovascular conditions including hypertension, thrombosis, acute coronary syndrome, and myocarditis most significantly in young individuals. This might happen if the mRNA vaccine has been used inappropriately. For instance, during the time of healing of a low noise infection when an individual's immune system is already very active. This leads to inflammation caused by Angiotensin-II which further contributes to tissue damage. Therefore, it could be inferred from the study that medical surveillance should be performed for patients with cardiovascular issues history who want to take mRNA spike vaccines for COVID-19 (Devaux & Camoin-Jau, 2023).