While our work highlights the significant advancements brought by Martini 3 and associated tools such as TS2CG and Polyply , it is important to acknowledge that these models and approaches also have limitations and potential issues. One notable limitation is related to the atomistic models used to parameterize bonded terms of lipids. Although lipid atomistic force fields have undergone extensive benchmarking and evaluations over the years , most efforts have focused on standard biological phospholipids, particularly PC lipids. A careful evaluation of models for ILs is still necessary. CHARMM36 with its extensive libraries provided by CHARMM-GUI , is one of the most promising atomistic force fields for this purpose.