Although shown with the PSYCHE ASR in Figure , the proposed WATERGATE pure shift experiment is compatible with a range of different ASR elements. The BS element is often used for acquisition of high sensitivity spectra, but is of limited general applicability as it is not broadband. The ZS ASR element enables acquisition of broadband spectra, but typically with lower sensitivity than its PSYCHE counterpart. The BIRD ASR is not appropriate here; it restricts observation to protons directly bonded to C, so it excludes signals likely to show exchange with solvent and in any case has intrinsic water suppression. The pulse program code (see Supporting Information, Section F) enables the user to choose the most appropriate ASR element (BS, ZS, or PSYCHE) for a given sample; see Supporting Information, Figure for example spectra.