The applied voltage in the ED step did not affect ion-separation performance but did influence electric power consumption. The removal of F(I) before the ED step is essential for achieving practicable power consumption. The RO results indicate that SO4-deprived ED diluate could be concentrated by >10 fold (recovery ratio 90%), with no evidence of membrane scaling. The RO permeate had a low salt content, enabling unlimited water reuse in the industrial process, thus improving sustainability and economics.