We introduced a methodology to follow nanoparticle synthesis from amphiphilic block copolymers in continuous flow systems in an automated fashion. Flow chemistry allows for very reproducible synthesis of nanoparticles, which for the first time allows to study effects of exact synthesis conditions on the obtainable size of nanoaggregates. For this matter, we varied the concentration of polymer in THF stock solutions, the mixing ratio of the polymer THF solution and water, and the total flow rate in the synthesis. A setup was built that allowed to control this variation fully autonomously and provide automated measurement of DLS size distributions concomitantly. The algorithm further provides continuously updated result sheets that allow the operator to follow the progress of parameter space screenings. The setup is described in detail in the supporting information, and we provide the software code on github () to allow other users to apply the code directly or to adapt it to their technical requirements.