PK Study Methodology C57BL6 mice of 8-10 weeks were used for PK study. Compounds (10µg/gm) were administrated orally or, intraperitonially (IP). Blood and tissue samples were collected at 10 min, 30 min,1 h, 3 h, 9 h and 24 h after drug administration. Plasma and tissue concentrations were measured by liquid chromatographymass spectrometry (LC-MS/MS).