Three phenyl system is present in the second and fourth most populated scaffolds in figure but the position of amide in chain allows antagonistic activity for the fourth scaffold. Meanwhile, the first and fifth scaffolds are based in the lactonic ring common in autoinducer and present all of the activities; being inadequate for similarity searching, but the rest of them would be useful. Scaffolds of PqsR DS are composed of two rings fused of six members, characteristics of natural autoinducer. All the molecules with quinoline ring (SC2) have an activity less than 10µM (see figure )), making it a suitable candidate for the similarity searching of new molecules with biological activity; another characteristic of this scaffolds is that the first two represent more than fifty percent of molecules, exposing a few diversity in this DS. The biological activity of the first five scaffolds found in RhlR DS is lower than the activity of scaffolds in the rest of DS, here all scaffolds have a lactonic ring, but the scaffold (SC4) with the largest percent of antagonist molecules, also presents a chain with an amide, an ether, and a phenyl.