Recent advancements in the Martini model, particularly Martini 3 , offer notable improvements. The latest version features enhanced bead packing through optimized cross-interactions between bead sizes, especially for charged groups, and re-parameterized bonded distances based on molecular volume and shape. These upgrades result in more accurate representations of lipid assemblies and improved packing of complex molecules. Furthermore, the expanded range of chemical bead types in Martini 3 enhances coverage of the chemical space, making it especially useful for modeling intricate LNP compositions used in vaccine delivery and gene therapy applications. The model's application is increasingly shifting towards more complex biological systems , including attempts to model entire cells . In support of this direction, several tools have been developed to aid these efforts .