Through pKCSM and SwissADME, the ADME properties showed that PB has the solubility of -6.077 whereas for the DN it is -3.099 log mol/L. The value for the intestinal absorption is almost the same for both the molecules. PB is the only molecule having P-glycoprotein I as well as II inhibitor properties. It is the only molecule which is a CYP3A4 substrate. The ADME properties are given in Table . The bioavailability radar (Figure ) as well as BOILED-egg approach (Figure ) of both the molecules demonstrated low BBB penetration and low GIT absorption. It has also demonstrated low in-saturation and solubility, whereas high polarity, lipohilicity, size, and flexibility of the molecules. The red dot on the yolk showed that these molecules can be used for human body.