Because it is involved in several physiological processes frequently dysregulated in diabetic settings, clusterin, also known as apolipoprotein J, has potential as a biomarker in diabetes . Clusterin is a secreted glycoprotein made inside cells and transported outside the cell . It is formed in organs such as the liver, kidneys, brain, and adipose tissue . When cellular stress, inflammation, or tissue damage-all prevalent in diabetes-clusterin production and release can be increased, which helps shield cells from harm, lessen inflammation, and encourage tissue repair . Diabetes is characterized by metabolic dysregulation and chronic inflammation, which have an impact on clusterin expression and release . Inflammatory cytokines, oxidative stress, and elevated glucose levels all promote the synthesis of clusterin .