In recent years, three-dimensional electron diffraction (3D-ED) techniques have emerged as a powerful tool for use in structure determination. Whilst conceptually analogous to single crystal X-ray diffraction (SCXRD), 3D-ED can overcome many of its limitations due to the strong interaction of electrons with the crystal potential. Combined with the use of focused electron probes, microcrystals up to a million times smaller in volume than would be needed for SCXRD can be studied . This addresses challenges in materials that are scarce, or where larger single crystals cannot be obtained. 3D-ED has become increasingly well-established for determining the structure of organic crystals in the past decade .