Automated synthetic chemistry has evolved from one-step synthesis of similar targets to multi-step synthesis with chemically distinct reactions. Recent studies have demonstrated the potential of automated synthesis modules in synthesis campaigns for a large set of targets, i.e., syntheses of chemical libraries. Computer-aided synthetic planning with the goal of automated execution must include not only the task of retrosynthetic analysis, but also the subsequent elaboration of abstract routes into specific, actionable hardware operations. This elaboration requires high-level considerations such as spatial arrangement/connectivity of devices (hardware orchestration), 14 as well as methods to specify operations. The precise timing of these hardware operations directly impacts the total duration of a synthesis campaign. As a simple example, parallel synthesis in reaction vials using a multi-position dry block heater is likely to be more efficient than sequential synthesis if multiple reaction steps can be run with the same temperature setpoint. The impact of optimizing the schedule of operations can be significant as synthetic chemistry laboratories tend to be highly modular and comprise independent hardware modules that allow highly parallel execution. As the size of chemical libraries for synthesis grows, so does the number of requisite hardware operations and interdependencies, motivating the use of formal optimization techniques for time-efficient multi-target synthesis.