Based on the results of the 39 reaction runs performed (Table and), some interesting trends were observed. The behaviours of the single-phase system and the two-phase systems are quite different. For the single-phase system (MeCN and THF), the higher flow rate led to an improvement in yield (e.g. entries 4 and 8 in Table ). On the contrary, for the two-phase system, lower yield was observed at higher flow rates (e.g. entries 18 and 36 in Table and).