CUR spatial distribution at different loadings Using the fitted sizes of each micelle section (Figure ) and their respective SLDs (Figure ), it is possible to estimate the amount of CUR, which is present in the respective component, i.e. the micellar core and shell. In this regard, the method established by Stenzel et al. [22, 23] was used and modified. The following assumptions were made for the calculation of 𝜙 ‚ƒv : Firstly, the second shell never incorporates any CUR, which may however not be entirely correct. Secondly, the D 2 O amount in the core is negligible for all CUR concentrations. The last assumption guarantees a solvable equation system. If the CUR amount in the core is not sufficient for obtaining the measured loading capacity, the CUR amount in the first shell will be increased accordingly. The resulting CUR volume fractions 𝜙 ‚ƒv of the core and the first shell show a clear trend for all three polymers (Figure ). ume fractions using the fitted SLDs of the core and first shell (Figure ) for A) A-pPrOzi-A, B) A-pBuOzi-A and C) A-pBuOx-A. The total volume fraction was constrained by the sum of both 𝜙 ‚ƒv of the core and first shell being identical to the reported loading capacities . Here, the volume of each micelle section (core and shell 1) was calculated using the structural parameters shown in Figure .