Semi-empirical determination of HSPs was also performed by dissolving the synthesized homo-/triblock copolymers at 20 g/L concentration in a library of solvents ranging from polar (protic and aprotic) to non-polar solvents (Figure ). Initially, the solubility profile of all the homopolymers was obtained. The POx based hydrophobic polymers i.e. pBuOx and pPentOx showed similar solubility profile with an exception to one solvent i.e. pBuOx and pPentOx were not soluble in toluene and sulfolane, respectively (Figure , column 1 and 2). For the POzi based homoplymers i.e. pPrOzi and pBuOzi, both exhibited a very similar solubility profile with only one exception; dimethoxy methane, in which pPrOzi was not soluble (Figure , column 3). The pMeOx homopolymer being hydrophilic, exhibited slightly different solubility profile as compared to hydrophobic homopolymers (Figure , column 5). Additionally, the solubility profile of all the selected ABA triblock copolymers was also obtained. Not surprisingly, the results showed that the solubility of triblock copolymers is strongly affected by the presence of hydrophilic pMeOx block. The solubility profile of both POx based triblocks (i.e. A-pBuOx-A and A-pPentOx-A) (Figure , column 6 and 7) was the same as that of pMeOx homopolymer. The POzi based triblocks (i.e. A-pPrOzi-A and A-pBuOzi-A) also followed the same pattern with a notable single exception to butyronitrile, where both POzi based triblocks were found soluble too (Figure , column 8 and 9). The semi-empirical SPs were obtained by utilizing the solubility score obtained as binary code, i.e. 0 (insoluble, red) and 1 (soluble, green) (Figure ) in the HSPiP software. The polymer concentration used for solubility testing was randomly chosen (i.e. 20 g/L), unfortunately, there is no defined rule for that. Important to note, different concentrations/temperatures and shaking time, may result in different solubility profile and in turn varied SPs. The semiempirical SPs determination was capable to differentiate between hompolymers which are structural isomers, because of minor differences in obtained solubility profile (Figure , column 1-4 and Table ). Within pure POx and POzi based triblock copolymers, identical SPs values were obtained because of identical solubility profile (Figure , column 6-9, Table ).