Accurately determining the standard enthalpies of formation (∆H • f , a.k.a. heats of formation) for diverse chemical species is essential for understanding and modeling chemical processes across drug discovery, energy research, and materials science. Because reaction enthalpies can be computed directly from the ∆H • f values of all participating species, accurate ∆H • f data play a pivotal role in elucidating a wide variety of chemical phenomena such as molecular binding, drug stability, combustion pathways, and material degradation mechanisms. Although experimental techniques can yield highly accurate