Cyclodextrin (CD) family hosts are composed of chiral glucose monomers linked to yield a cyclic polymer. The SAMPL7 challenge focused on modified CDs provided by the Gilson lab, which synthesized monofunctionalized derivatives differing by addition of a substituent projecting outward from a primary or secondary face hydroxyl of the cyclic oligosaccharide (Figure ). The CD host derivatives and native (unmodified) CDs have a truncated cone shape (Figure ) with a hydrophobic cavity and a hydrophilic surface, while the substituents are intended to alter the host's chemical and physical properties. The new host substituents introduce new host-guest interactions, while retaining some of the same binding characteristics .