Here, we present the results from independent all-atom molecular dynamics (MD) simulations of the plant secondary cell wall (Animation S1) with different water weights, ranging from 0 -30 wt% water, which span the realistic range for wood moisture content. First, we calculate the diffusion coefficient (D) of cell wall polymers, ions, and water at different water weights. In addition, we calculate the diffusion coefficient of ions (Na + , K + , Ca 2+ , Cl -) in the cell wall and find that our results agree well with previously reported X-ray fluorescence microscopy measurements . Next, we quantify the contacts between different cell wall polymers using Eq. 1. Both molecular diffusion and measured contacts between cell wall polymers exemplify changes in the mechanical properties of secondary cell wall at varying moisture levels. Visually, the increase in diffusion is immediately apparent from our trajectories. As shown in supporting animation S2, cell walls with low moisture content appear to be essentially static over the microsecond long trajectory animations. By contrast, increasing hydration creates trajectories that are visibly more dynamic (Animation S3), even if the overall structure remains relatively consistent over the simulation timescale.