Abaucin was selected as parent to generate children molecules because it is among the most recently described antibiotics anti-A.baumannii displaying low micromolar activities. The LolCE model was selected as target because despite the absence of a crystallographic abaucin-bound A.baumannii model, the elucidated E.coli LolCDE protein complex 3D structure 16 could be used to predict an alphafold A.baumannii model with high accuracy (Figure ).