Multivariate materials composed of several distinct functional units are attracting interest due to their advanced versatility. Metal-organic frameworks (MOFs) offer a unique scenario for such materials due to their intrinsic chemical tunability. Zeolitic imidazolate frameworks (ZIFs) are a subclass of MOFs formed by tetracoordinated metal centres and imidazolate linkers, resulting in extended solids with zeolitic topologies. The most studied ZIF is arguably ZIF-8, formed by 2methylimidazolate (mim) and Zn(II), presenting a sodalite (SOD) topology, i.e. interconnected porous cages by six and four membered rings with small pore apertures. The SOD topology is not exclusive of ZIF-8, and can be obtained through direct synthesis with other metals, such as Co(II), Cd(II), Mg(II), Mn(II), and Fe(II); with substituted imidazole derivatives in the 2-position, such as 2-chloroimidazole, 2bromoimidazole, 2-nitroimidazole, and 2carbaldehydeimidazole; or in the 4-and 5-positions, such as benzimidazole. Very recently, this number of imidazole derivatives has been further expanded through the use of mechanochemistry. This versatility in both the metal and the ligand results in the modulation of properties such as the network flexibility, which has shown to be fundamental for key properties, as in catalytic applications, and indicates the possibility of fine-tuning the properties through a combination of ligands, as reported in other families of MOFs. However, other ligands that would normally form different structures are challenging to be incorporated into the SOD structure of ZIF-8 through a direct synthesis. In fact, the mixture of such ligands normally induces changes in the topology. In addition, the inclusion of a second ligand in the SOD topology is of interest to enhance the stability of the framework. In this sense, Friščić, Navrotsky and colleagues have recently suggested a thermodynamic approximation to enhance the ZIFs stability, focussing on the effects of different substituents of the linkers, contrary to the common approach of focussing on the kinetic effects. Thus, this idea can be extrapolated to obtain thermodynamic stable SOD ZIFs through the combination of several ligands.