Next, conformers were generated with OMEGA. 27,28 OMEGA features a "default" or "classic" mode, which handles molecules with rings formed by up to nine atoms, and a macrocycle mode, which handles molecules with larger ring systems. Accordingly, OMEGA's default mode was employed to generate conformer ensembles with a maximum of 400 conformers per enantiomer for all non-CSMs without any rings formed by more than nine atoms (the flipper option, which enumerates the stereochemical configurations of undefined chiral atoms, was enabled).