This study highlights the potential of tri-doped TiO₂ photocatalysts for the degradation of ciprofloxacin (CIP). Among the catalysts tested, B1Ce1Ag0.1TiO₂ emerged as the most effective, achieving a degradation efficiency of 54% at 10 ppm CIP concentration under UV-A light. However, the performance of these tri-doped catalysts remains inferior to bare TiO₂ under UV conditions. The findings underscore the importance of optimizing dopant levels, enhancing visible light activity, and addressing challenges related to large-scale application.