To tackle these synthetic, legislative and environmental challenges, our strategy centered around the development of a versatile protocol capable of generating N-, S-and O-CF3 anions on demand, and facilitate their immediate use as nucleophiles (Figure , reaction design). This strategy entails the preparation of trifluoromethyl-heteroatom anions using alkali fluoride salts, as a fluorine source, in conjunction with appropriate precursors for each motif. In devising this reaction blueprint, certain criteria must be met: the precursors should be (i) bench-stable, (ii) commercially available or easily prepared, and (iii) operating in high atom economy. Conceptually, our envisioned mechanism involves the sequential preparation of the trifluoromethyl group from these precursors through two successive chlorine-fluorine exchange reactions, culminating in a final fluoride addition to yield the desired nucleophiles. These reactive species would then be primed for immediate reaction with suitable electrophiles to form new C-N, C-S or C-O bonds.