Murko's definition, 3) ring systems, and 4) computed list of fragments using the RECAP algorithm of fragmentation. The ring systems of the studied data sets were correlated versus a virtual database of ring systems with reported bioactivity, Magic Rings, computed and released by Ertl. 28 Also, we analyzed the chemical multiverse of NAPROC-13 by using different types of molecular representations, including physicochemical, constitutional, and fingerprint-based descriptors. The chemical multiverse is a set of multiple chemical spaces, describing the same set of molecules through different sets of descriptors, each one describing the compounds differently but in a complementary manner. We used the COlleCtion of Open Natural ProdUcTs -COCONUT-database to approach the known chemical space of NPs. Results of this investigation showed quantitatively the large structural diversity of NPs. The results also confirmed the vast chemical diversity of the NAPROC-13 database, which is well suited for NP dereplication and virtual screening on different target families, including the report of more than 4000 new NPs. Some examples of those new included natural products are shown in Figure . NAPROC-13 showed a high structural diversity as well as the presence of interesting substructures (molecular scaffolds, Magic Rings, and molecular fragments) suitable for the discovery and design of drug candidates, including the development of pseudo-NPs.