The bias potential is deposited to CVs at every kτ , where k is an integer and τ is the interval. In the WTMetaD simulation, the time interval V (s, t) is updated as the simulation progresses, and the intermediate structures in the search phase space are explored while avoiding revisited s. V (s, s(t)) in the WTMetaD simulation is scaled by γ, meaning that the increment of V (s, t) becomes gradually smaller over time with well-parameterized γ.