In recent work, Farhadi Jahromi and Schmid looked into the microscopic mechanism of the dielectric response of MOFs with rotatable polar groups, as a function of the load of the pores with guest species of different polarities. They used classical MD simulations with constant field methods based on the electric enthalpy Hamiltonian and showed that the adsorption of a polar guest (methanol) leads to drastic changes in the response of the material, inducing paraelectricity in the spatial directions that showed linear dielectric behavior for the bare MOF. Furthermore, the confinement of the guest molecules induced an anisotropic response. This study suggests the potential use of MOFs with dipolar rotors as dielectric response-based molecular sensors.