First, we wanted to confirm that the TMAP visualization aligns with intuitive distributions of structural features relevant for peptides. For that, we colored the data points based on their heavy atom count (HAC), an indicator of molecular size, and fraction of carbon atoms (fraction C), a simple proxy for the hydrophobicity of a peptide sequence. The TMAP revealed visible clusters for both, HAC (Figure ) and fraction C (Figure ), indicating that the reduced MAP4C features can reliably represent simple molecular descriptors in the underlying chemical space.