As shown above, the mechanisms of chemical and thermal denaturation processes are different. Thermal denaturation is an endothermic process, and chemical denaturation is an exothermic process. This endothermic type of denaturation can be demonstrated using recalculated experimental data of as the temperature dependence of lnK with a negative slope of the Van't Hoff plot. The data is presented in Figs. and. The total enthalpies for chemical denaturation have been calculated using equation 37 according to experimental data of and Hansen parameters recalculated for the temperature of the experiment.