Starting first with the reaction of pivaldehyde with bromoanisole 1 and quenching into MeOH, we could see that the chip-based reactor was able to generate a reasonable (45%) yield of fluoroarene 9 from a 2 mL injection volume (corresponding to a 56 mg input of 1). To assess the relevance of metalation rate on yield, we also reacted bromoarene 8, a substrate which metalates rapidly relative to 1 , with TMSCl. Data are reported in Figure . We note that yields for both reactor designs start to plateau at injection volumes greater than 4 mL across both substrates; that is to say, past an injection volume of 4 mL, the primary influence on yield for each aryl halide-electrophile pair seems to be their intrinsic reactivity under these conditions rather than reactor volume. On this basis, we suggest the following aryl halide material inputs for these reactor systems (Table ).