The overall energy change for hydrolysis on graphene is -167.76 kcal/mol the vertical state 1 is unlikely as the rate-determining because of their low activation energies. The reaction pathways for hydrolysis reaction on the vertical 1 graphene system were worked only on the triplet state. The hydrolysis reaction of (ZnO) 3 on the vertical 2 graphene system was successful on both states with one water molecule but not with the second water molecule.