Transcription-repair-coupling factor C-terminal (IPR005118). The transcription-repair coupling factor (TRCF), which is the product of the mfd gene, is responsible for the coordination of DNA repair and transcription in bacteria. TRCF directs nucleotide excision repair (NER) machinery to the site and removes transcription elongation complexes that have become stalled at DNA lesions. It improves transcription-dependent inhibition of nucleotide excision repair (NER) by finding and removing RNAP that is stuck on damaged DNA with the help of ATP. Additionally, it stimulates DNA repair by recruiting Uvr(A)BC endonuclease. TRCF's C-terminal region is required for RNAP displacement.