The main remaining question to be answered is: How come the D-(A)8-A peptide in MeOH supports PT from D to A, taking into consideration the hydrophobic nature of the Ala side chain? To answer this question, we will refer to the peptides' structure, as estimated using MD. The only structural feature of the (A)8 peptide that can support PT is its polar backbone, which can participate in hydrogen bonding. Accordingly, the estimated α-helical structure of the D-(A)8-A peptide can result in a pathway for PT from D to A. However, the observation of PT for the D-(A)8-A peptide only in MeOH and not in CHCl3, although the peptide adopts an α-helix structure in both solvents (Fig. ), suggests that the structure is not enough, and there is a need for the polar MeOH molecule to bridge-in between the polar moieties of the peptide backbone to facilitate PT across the peptide.