The Ig-like structure of the transmembrane protein ORF8 overlaps with the MHC-like system. The dimer of ORF8 has no rod-like structure. Table and the crystal structure view of ORF8 (PDBID: 7jtl) show that the MHC II and MHC I structures of ORF8 include sites near the groove structure. Therefore, ORF8 may trapp antigen peptides through the MHC structure and interfering with antigen presentation. Besides, ORF8 captures MHC-1 and reroutes to autophagosomes for degradation . Table indicates that the MHC I-like domain of ORF8 is MHC_I-like_Ag-recog. ORF8 also has the MHCassoc_trimer domain. The MHC II-like domain of ORF8 overlaps with the MHC_I-like_Ag-recog and MHCassoc_trimer structures. So ORF8 may trap MHC I by MHC_I-like_Ag-recog and MHCassoc_trimer domains. Therefore, the MHC-like system of ORF8 has a decoy function for MHC I or antigen peptides.