The coupling between biochemical disease states and treatment effects on tissue biomechanics represents an area ripe for investigation. This is particularly relevant in conditions like uterine fibroids, where aberrant growth factor signaling couples with altered biomechanical properties to promote fibroid growth . Treatments such as hormonal therapies or surgical intervention can alter tissue mechanical properties, which, when combined with knowledge of transport dynamics, can lead to improved treatment efficacy . Thus, the use of anti-inflammatory agents in treating endometriosis can not only mitigate pain but also restore normal tissue biomechanical integrity, facilitating fertility restoration. Biochemical changes due to diseases like PCOS or endometriosis lead to alterations in tissue biomechanics. For example, the excess secretion of androgens in PCOS affects follicular development, contributing to mechanical instability within the ovaries. Treatments targeting these biochemical anomalies must consider the resultant shifts in tissue mechanics to be effective . Specific case studies illustrate the connections between chemical transport, reproductive diseases, and biophysical disturbances. For instance, research on uterine fibroids reveals that enhanced blood flow contributes to their growth, highlighting the interplay of transport mechanisms and disease states . Similarly, studies on ovarian reserve depletion provide insights into how altered species transport dynamics may contribute to age-related fertility declines. PCOS is characterized by hyperandrogenism, insulin resistance, and ovarian dysfunction. Elevated androgen levels can affect follicular development and ovulation by altering the diffusion of key signaling molecules and disrupting follicular fluid flow . Preeclampsia, a pregnancy complication characterized by high blood pressure and proteinuria, is often linked to disruptions in placental perfusion and oxygen transport due to altered blood flow and diffusion .