EGBO was applied to the optimization of AgNP synthesis in a hyperspectral HTE platform (see Fig. , right). The HTE platform includes a microfluidic reactor to produce reacting droplets, and a hyperspectral imaging system to capture their UV/Vis absorbance spectra in situ . The chemical composition of the droplets is controlled by the flowrate of each reactant: silver seed, silver nitrate (AgNO3), ascorbic acid (AA), trisodium citrate (TSC) and polyvinyl alcohol (PVA). These flowrates define the 5 decision variables of the cMOOP.