The source code for ROSHAMBO is publicly available on the Biogen Molecular Informatics GitHub page (github.com/molecularinformatics/roshambo) and on oschem.biogen. com, along with extensive documentation, installation instructions, and demo files for both the Python API and command line interface. ROSHAMBO is adaptable for many use-cases across industry and academia, with all common tunable parameters exposed to the user, and featuring a code base that can be changed, improved, and adapted. We also include analysis modules to allow a user to benchmark the methods themselves, and visualization tools to help understand their performance. The ROSHAMBO implementation was designed to be user-friendly and easy to deploy in both industrial and academic settings, with simple commands and methods that easily slot into larger Python or Bash-based workflows. We have made ROSHAMBO freely available as part of a larger effort to deliver and maintain high-quality, open-source tools for all scientists working in drug discovery.