Developing such optimization frameworks for electrochemical cells using continuum models has been the focus of few studies so far. For example, Roy et al. developed a topology optimization model for architected electrodes in redox cells and supercapacitors using the finite element method. Their model consisted of thick electrodes and lacked mass transfer and fluid flow, which enabled them to use symmetry to simplify the geometries and reduce the simulation time. Beck et al. proposed an optimization framework using finite volume method in which they developed a multi-physics model solving mass, charge and momentum equations by employing transport quantities derived from a set of pore-scale simulations. Their study featured limited operating conditions due to dimensional analysis and lacked manufacturing and dehomogenization strategy. Using a similar model, Li et al. , developed an optimization framework for redox flow batteries, but the model would optimize the design of the flow fields. All the mentioned studies were performed using symmetric cell setup. Inspired by the work of Roy et al. , we demonstrate for the first time a topology optimization framework integrating the fluid flow and the charge transport models for electrochemical flow cells using dimensionless analysis allowing us to investigate a wide range of transport regimes.