To generate transition state guesses for uni-and bimolecular reactions, we employed the algorithm implemented in Chemoton named Newton Trajectory scan (NT2), which is inspired by the Artificial Force Induced Reaction (AFIR), and the use of Newtonian forces for computing an effective PES. We restricted the size of the compounds in the two networks as follows. NT2 trials that led to activation barriers greater than 250 kJ•mol -1 (according to the method which was used for the exploration) were dismissed, as the subsequent reaction would be unlikely to happen. The chemical reaction network of ethene and ozone (CRN-E) contained a maximum of 2 carbon atoms, 4 hydrogen atoms, and 3 oxygen atoms (i.e., the size of the ozonide) to reduce the computational cost of the exploration (see further discussion below and Section S2.2). CRN-T for reactions of tetramethylethene and ozone was made up of a maximum of 6 carbon atoms, 14 hydrogen atoms, and 3 oxygen atoms. This threshold has two hydrogen atoms more than the tetramethylethene-ozonide, in order to allow the search for the relevant side product, 2,3-dimethylbutane-2,3-diol. We stopped the explorations once the expected, experimentally confirmed products were found, and the subsequent evaluations of the networks led to the correct mechanistic and kinetic results.