In the realm of rational drug design, molecular electrostatics and lipophilicity (expressed as logP, the octanol-water partition coefficient) stand out as crucial properties embedded in Quantitative Structure-Activity Relationships (QSARs). The inception of logP as a molecular descriptor traces back to the classical Hansch QSAR methodology, where it serves as a key indicator of a drug molecule's attributes . According to Lipinski's rule of five (Ro5), logP is one of the significant parameter considered to predict the oral bioavailabilty of a drug. The partitioning behaviour between octanol and water predicts the hydrophilic or lipophilic nature of a drug .