Benchmarking the quantum-mechanical benchmarks towards "platinum standard". Reliable models for pocketligand systems rest on robust methods performing consistently and accurately in such systems. A prerequisite towards understanding and estimating the performance of current methods is the existence of reliable data, which can be challenging when results in literature obtained at "gold standard" level of computation have been found to disagree , and comprehensive and computationally expensive studies are needed to explore sources of the discrepancy . Hence, to establish a thoroughly Comparison of the interaction energies (E int ) computed using Diffusion Monte Carlo, QMC (0.025 time step) and LNO-CCSD(T) (CBS limit) for a selection of 13 equilibrium QUID dimers. Three cases are highlighted: L3I1 for which the methods are in perfect agreement, F2B1 for which the methods agree within their uncertainty estimates, and SF3I3 as the one case for which they are in slight disagreement. The NCI plots illustrating the non-covalent interactions in those molecular dimers are also shown .