The regular use of well-known herbicides has led to the problem of plant resistant strains to herbicides caused by natural mutation throughout the generations ; for example, there are 2 plants involved in the same soil, plant and weeds. Responses to weed resistance at the molecular level include creating new small molecule herbicides or genetically altering wanted plants to be resistant to known or in development herbicides (such as the change P197S and Chlorsulfuron here). Weed, or other, control is an economical and well researched means of maximizing harvest.