For the D-cascade, 2-OMe and 2-MOE products 11b and 12b were obtained in high analytical yields (74%, 62% respectively) and good isolated yields (46%, 47%). Interestingly for 11b, the scale up analytical yield was higher than any of the previous optimization reactions carried out in 200 µL volumes. When compared to the L-lyxose-5-phosphate products, D-ribose-5-phosphate analogues contained a small amount (<10%) of pyruvate present in the purified sample, which is a by-product of the pyruvate kinase recycling system.