The Wuhan coronavirus genome was obtained from Genbank/NCBI (release MN908947.1). Sequences from crystal structure sequences were obtained from the Protein Data Bank (rcsb.org). Sequence analysis was carried out using the web interface at the European Bioinformatics Institute (EMBL-EBI). Pairwise sequence alignments were performed using the EMBOSS-Needle method with default EBLOSUM62 matrices. Multiple sequence alignments were carried out using Clustal Omega using default HMM profile-profile parameters. Blast searches were carried out against the full UniProt Knowledgebase using blastp 2.9.0+ and default parameters.