We utilized our approach for ligand similarity-based placement and re-scoring with MM-GBSA to participate in all the three stages for the biomolecular target BACE-1 in D3R GC4. As detailed in the methods, Stage 1a of the challenge involved cross-docking prediction for 20 ligands, affinity ranking for 154 ligands and binding affinity prediction for a subset of 34 ligands. Stage 1b included self-docking challenge for the same 20 ligands as in Stage 1a. For Stage 2, the cocrystal structures corresponding to the 20 BACE-1-ligand complexes from the pose prediction challenge were released and we were asked to recompute the affinity ranking as well as the free energies.