Pro-inflammatory macrophage differentiation is a process that promotes the pathology of a wide range of diseases . Monocytes are circulated innate immune cells and the main participants in cytokine storm and related pathology in COVID-19 . The signal transduction receptor CD14 of LPS is a key marker and a promoter of pro-inflammatory macrophages' function. CD14 + CD16 + inflammatory monocyte subpopulations are found more frequently in COVID-19 patients. CD14 + CD16 + monocytes also show high levels of IL-6 expression, which speed up the process of systemic inflammation . After being infected with SARS-CoV-2, these people often show hypercytoemia. It indicates that SARS-CoV-2 induces white blood cells to respond to lipopolysaccharide (LPS), and secret cytokines such as tumor necrosis factor-α (TNF-alpha) and interleukin 1 (IL-1) . Excessive secretion of TNF-α causes endotoxin shock, usually a fatal complication .