We evaluated the interaction strength of the close contacts between galactose and aromatic amino acids to assess the contribution of individual side chains to non-covalent proteincarbohydrate binding. We computed interaction energies using low-cost hybrid DFT (i.e., B3LYP-D3) and performed energetic decomposition analysis using symmetry-adapted perturbation theory (SAPT0) , and functional group SAPT (F-SAPT) for the full dataset of close contacts (Supporting Information Figure ). These methods were selected for computational efficiency.