The underlying dataset used to develop and test RegioSQM contains more than 80 different mono-and bicyclic aromatic cores bearing more than 50 functional groups directly on the rings that undergo the reaction as well as and more than 30 commonly used protective groups and important reactive functionalities in organic synthesis. This structural array not only illustrates the high chemoselectivity of EAS chemistry, but also that RegioSQM is applicable to essentially any molecule of interest. Consequently, chemists can apply the method in the planning of synthesis routes and confidently begin to contemplate novel approaches to target molecules where the strategic halogen atom be introduced at any stage of the synthesis pathway either to introduce a halogen in the final molecule, as protective groups to block more reactive sites to ensure the desired regiochemical control, or to introduce a halogen handle for a subsequent step. In other words, chemists would be in the position to predict the site selectivity of EAS reactions and focus on the synthesis of key scaffolds suitable for late-stage functionalization, for example to support efficient SAR explorations. Readers are encouraged to test RegioSQM on the webserver regiosqm.org.