As an additional part of this study on the start-up process of the pilot column, the differences between the start-up process in the simulation model and the start-up process of the pilot column are investigated. For this comparison, all effects and findings from the simulation study, the experimental study, and other acquired experiences with the pilot mDWC are considered. The start-up strategy with the shortest start-up time derived from the previously described study is applied to the simulation and the experiment.