Two of these methods, AMOEBA/DDM/BAR and MD/DOCKING/GAFF/xtb-GNF, tended to yield binding free energies which were too unfavorable while the FSDAM/GAFF2/OPC3 ranked method was too favorable (Figure ). Thus, most predictions with errors larger in 2 kcal/mol in magnitude err in the direction of not predicting binding to be favorable enough, especially with AMOEBA/DDM/BAR and MD/DOCKING/GAFF/xtb-GNF are underpredicted (Figure ). On the other hand, as shown by Figures and, the FSDAM/GAFF2/OPC3 method errs in both directions more frequently.