RAMD is an MD-based algorithm used to accelerate the dissociation of a ligand from its receptor binding site. Throughout the RAMD simulation, a constant force is applied to the ligand's center of mass. The direction of this force, but not its magnitude, is randomly selected and continuously applied for a predefined interval Δt. After this time, the displacement of the ligand from its previous position is measured. If the displacement is within a given threshold (Δd), the force is reoriented randomly for the next interval Δt. Otherwise, if the displacement is greater than Δd, the force continues in the same direction. This ensures the ligand is discouraged from proceeding in a direction where steric clashes are encountered, and is more likely to proceed following plausible egress paths. While in some cases, the RAMD simulation time has been found to empirically correlate with experimental residence times, 1 here, we use RAMD to harvest plausible egress trajectories.