Good binding affinity and reactivity response suggested that the studied medications can be promising drugs to inhibit the COVID-19 invasion. As Table shows, we can conclude the importance of some amino acids (highlighted) that belong to the antenna of the spike virus in binding with the target medication. Remdesivir, Molnupiravir (EIDD-2081), and Quercetin showed significant binding interactions with the antenna of the SARS-Cov2. Other drugs interact mainly with the ACE2 amino acids, blocking their receptor function.