The explanations for the calculated probes are the same as for the experimental but show a different pattern in the 11 rows of Table . Since these are predominantly derived from ChEMBL, the matches against this source, BioAssay active and BindingDB are all high. In contrast, vendor matches are proportionally much lower. While the patent intersection drops to 61% this still impacts 2,227 CIDs. The explanation lies in the fact that many of the organisations (academic or commercial) generating the medicinal chemistry papers that ChEMBL curates (and Probe Miner selects) also file patents on their characterised compounds in advance of publication. Notwithstanding potential IP complications, it is important to note that patent matches are potentially advantageous for probe evaluation because they may well contain unpublished selectivity and SAR data not captured in probe sources.