In the Watrous studies , more than 500 "unknown or putative oxylipins" were discovered, and as initially hypothesized in this manuscript and one of the purpose for this NEO-MSMS library, we believed that some of them could be related to NEO-PUFAs. We subsequently reanalyzed the data presented by Watrous et al. in 2019 through a conventional molecular network, using the same parameters and incorporating our library NEO-MSMS. However, the MS/MS files available present a mass error that can exceed 0.04 m/z and could not be used to match lipid databases for predicting known fragmentations (simple loss of water or CO2 are already off target to match any formulae of oxylipins). Nevertheless, the power of molecular networking is that by increasing the mass error tolerance to 0.1 instead of 0.02, we could carry out dereplication. However, still due to the complexity of further analysis of the data, we specially focused on three specific oxylipins; i.e, oxylipin 1, 2, and 3 (named as such in the original text) which showed significant changes after one-year PUFA n-3 treatment (VITAL study) and associated with clinical lipid and inflammatory biomarkers . We also looked at five other unidentified putative compounds from the original Watrous et al. study which were frequently found to be associated with multiple correlates of inflammation, while other putative compounds, were specifically linked to age, BMI, or CRP levels, suggesting both universal and specific inflammation mediators .