In this study, we developed an advanced automated synthesis platform to accelerate the assembly, crystallization, and polymorph screening of cocrystals, continuously capturing experimental data at each stage as shown in Fig. and Supplementary Fig. . This platform, optimized for the discovery of polar cocrystals, also demonstrates broad applicability in materials science. By integrating HT automated screening, it facilitates the efficient exploration of large chemical spaces and the precise identification of promising candidates. The platform is equipped with robotics, precision dispensing systems, and AI-driven computer vision to ensure HT and reproducibility across experiments. A six-degree-of-freedom robotic arm, with pneumatic and electric grippers, performs complex tasks such as solvent dispensing, vial capping, and sample transfer, mimicking human actions with enhanced accuracy and speed. Solid and liquid dispensing stations further optimize sample preparation, while an AI-enhanced computer vision system classifies crystallization products, distinguishing between liquids, single crystals, and polycrystalline powders with a classification accuracy of 0.925 (Supplementary Fig S7 ). The 5 details for the platform hardware and software are in Supplementary Information Sections 9 and 10.