The sample preparation for metabolomics experiments is inexpensive and easy compared to other omics technologies and can be fully automated in many cases . In addition, constant improvements in throughput are taking place, such as UHPLC-MS systems for shorter chromatographic runtimes, as well as chromatography-free direct infusion and flow injection technologies . These techniques allow researchers to perform large-scale studies and achieve acquisition rates of hundreds to thousands of samples per day, with some methods reaching to less than one second per sample in acquisition time .