In addition, our methodology enabled the synthesis of diverse amino acid derivatives for peptide synthesis, incorporating orthogonal protecting groups, requiring only minor adjustments to reaction conditions. We evaluated acid-, base-and hydrogenation-labile protecting groups, including tert -butyloxycarbonyl (Boc), fluorenylmethyloxycarbonyl (Fmoc), and benzyloxycarbonyl (Cbz) resulting in the successful preparation of the desired building blocks