Precious metals such as Ru , Pd , Pt , Re , etc. are more commonly used in nitrile hydrogenation reduction and some heterogeneous catalysts have superior conversion effects . However, the scarcity and high cost of precious metals hinder their widespread industrial application, while transition metals , which are more abundant in earth resources and have lower costs, have come into the public eye . Homogeneous catalytic systems including Co-, Fe- , and Mn-complexes show good selectivity under mild conditions and are of great interest to researchers . Bornschein's team was the first to use the iron PNP clamp complex to achieve good functional group tolerance. Esters, ethers, acetamidobenzenes, and amino substituents were not reduced in the presence of nitriles. The complex developed by the team constituted the first example of homogeneous catalysis, successfully achieving the selective hydrogenation of industrially important dinitriles to 1,6-hexanediamine. Mukherjee's team first reported a reaction case catalyzed by Co PNNH clamp complexes to produce primary amines selectively. Elangovan's team first described the use of manganese clamp complexes in the catalytic hydrogenation of nitriles, ketones, and aldehydes. However, metal contamination and recycling issues of these catalytic systems limit their commercial development and large-scale utilization. In heterogeneous catalytic systems, metal catalysts such as Ni and Co usually hydrogenate nitrile compounds under harsh conditions . From the perspective of green chemistry and sustainable development, it is of great significance to develop non-precious metal catalysts that can show high activity under mild conditions. Recently, much more fit for the above requirements of green chemistry and sustainable development, the advanced flow synthesis methodology attracted more and more attention. The continuous flow technology can better control process parameters , improve mass transfer and heat transfer , shorten reaction time , improve reaction safety , and make up for the shortcomings of traditional intermittent reactors in many aspects such as low production capacity and difficult catalyst separation . Due to the limitation of microchannels and the dominant role of capillary forces , the gas-liquid flow in micro-packed bed reactors differs from that in kettle reactors . The gas-liquid contact is more complete at the microscale, and the mass transfer performance is 1-2 orders of magnitude higher, which is conducive to the high selectivity of target products . To the best of our knowledge, there are still limited reports on the hydrogenation of nitriles via biobased Co heterogeneous catalyst in continuous flow.