Atmospheric molecular clusters often become quickly solvated by a few water molecules due to high air humidity. Therefore, the consideration of hydration becomes essential in the study of atmospheric clusters, which introduces water as an extra component, increasing CS complexity. Water can also function as both an acid and a base, potentially introducing reactivity through proton transfer reactions. For simplicity, hydration was often omitted in studies involving atmospheric acid-base clusters. However, this introduces an additional source of error in such studies, as the impact of water can enhance cluster formation by up to two orders of magnitude. Rasmussen et al. 101 demonstrated that for water-containing clusters, the approach of Kildgaard et al. can outperform the JKCS method presented here. Their technique requires knowledge of low-energy structures for 'dry' clusters and involves sequentially inserting water between existing bonds or around the cluster, exploring only a fraction of configurational space.