Global health is a vital practice that aims to provide healthcare to all individuals in a fair and equitable manner across the world. It encompasses a range of factors, such as environmental safety, food and water quality, and disease control, all of which are interdependent and can influence each other. For instance, environmental pollution can contaminate water sources, leading to water-borne diseases, and vice versa. Although local or regional issues can be tackled, infectious diseases present a significant global health challenge. Accessible and affordable testing for infectious diseases is crucial to prevent their spread. Microfluidic diagnostic technologies have shown promise in providing low-cost and informative testing for infectious diseases such as COVID-19, HIV, tuberculosis, and malaria. Traditionally, microfluidic devices made of silicon and glass have provided geometrical precision and reusability, but they are expensive to scale. Polymer substrates like thermoplastics and PDMS are moderate in cost and enable middleto-high-throughput fabrication. However, recent trends in microfluidic point-of-care diagnostics have sought to use inexpensive disposable materials such as paper and thread to improve scalability and ease of use. Paper-based analytical substrates have been used since the 1940s for chromatography and electrophoresis.