A mixture of bromide (1 equiv), alkyne (1.5-5 equiv), and TEA (1-3 equiv) in DMF was degassed, followed by addition of Pd(PPh3)4 (0.1-0.2 equiv) and CuI (0.1-0.2 equiv). The reaction mixture was heated to 85 ℃ and stirred overnight. After completion of the reaction, the mixture was cooled to r.t., diluted with EtOAc, and passed through a thin pad of celite. The filtrate was concentrated in vacuo and the crude residue was purified by preparative HPLC (10-100% MeOH in H2O + 0.05% TFA) to give the title compounds.