Integrating metabolomics with other omics approaches, such as transcriptomics[100-102], proteomics[103-105], and fluxomics[106-108], poses significant challenges in the study of plant-microbe interactions. While metabolomics provides a comprehensive snapshot of the metabolic profiles of both plants and their associated microbes, enabling the identification of key metabolites involved in these interactions, the interpretation of this data in the broader context of the molecular mechanisms underlying these complex relationships remains a significant hurdle 5 .