While the correlation between the experimental and predicted ∆∆G values is of significance, the strength of the solvent interaction is of equal importance. Molecular balance D1, for instance, shows an excellent correlation with PCC = 0.92 for the SMD solvent model, even though the differences between the solvents are too small, leading to a slope of 0.34. Therefore, we also evaluated the capability of an implicit-solvent model to reproduce the correct relative interaction strength by calculating the slope between experiment and prediction (bottom panel of Fig. ). This analysis revealed that while the SMD model achieves good correlations, it systematically underestimates the difference in ∆G between the different solvents, manifesting in slopes that are significantly below one. While the same trend was observed for the openCOSMO-RS model, the QM-GNNIS model captures the differences well, resulting in slopes centered around one.