We find one end product, mycophenolic acid (Reaxys ID: 8644904), where screening via RPDF search does not lead to a route, but the DF search in cut-off five finds one route. This means that from none of the tested strategical molecules mycophenolic acid was accessible in three steps. Further, we find an end product, valepotriate (Reaxys ID: 4339241), where no paths are found by both DF screening in cut-off five and RPDF screening in cut-off six. As we are searching for highly complex and functionalised molecules, e.g. in the case of valepotriate four chiral centres, it is not surprising that neither search finds a path when six steps is the average connectivity for any pair of nodes. Still, the RDPF search presents such negative results in shorter computational times. Based on three experiments we have demonstrated that with regard to short screening ranges the strategic molecules are significantly better connected than sets of random molecules. We further indicate that the RPDF search can be used to compare the strategic molecules with one another. Last but not least, we outline promising reaction options in shorter CPU times than by DF screening.