In our platf orm, the 4-A TP f unctionalized electrodes can be biased to exchange protons with the electrolyte. This reaction is more eff icient af ter the dimerization of 4-ATP . The dimerization was carried out in water by electro-polymerization with cyclic voltammetry. Before cycling the acid/base control, the cell was placed in the open position and the electrodes were connected to the potentiostat using a three-electrodes system. A cyclic voltammetry (CV) program was applied in the range of -0.6 to + 0.6V at a scan rate of 25mV/s for 5 cycles in presence of the dye (FAM 0.5uM) in KCl (100mM) (f ig.1(c)). The voltammograms corresponding to the electropolymerisation exhibited two main contributions in the oxidation peaks corresponding to the reversible exchange of protons and the dimerization at ~0.1 and 0.4V respectively. As consecutive cycles were perf ormed the main peak corresponding to the dimerization disappeared and the main contribution remained by the peak at 0.2V corresponding to the two proton exchange reactions. The details of all these reactions were studied in our previous article . In some of the chips, other residual contributions that we ascribed to non-dimerized molecules could also be observed between the two peaks of the dimerized molecules and the electropolymerisation. For the experiments in organic solvents, the FAM was used with the same initial concentration 0.5μM in a solution of Bu 4 PF 6 100mM in A CN. In organic medium, the CVs were performed between 0 to 1V vs pseudo ref erence with a scan rate of 30mV/s. The deprotection of Boc acid labile groups occurs with the application of a linear swipe up f rom 0 to 0.85V, a f ixed voltage (0.85V) f or 1 min and then a second linear swipe up f rom 0.85 to 0V.