The CHARMM/VMD lab is run in a standard computer room, equipped with PCs, with one post-doctoral demonstrator managing two postgraduate assistants who all can answer questions and deal with technical issues as they arise. For the purposes of this experiment, we ran the iMD-VR component in a separate room, to ensure that each student's iMD-VR starting point was similar. The students were taken to the iMD-VR room individually and introduced to the controllers. We described to students how the buttons on the real-world controls corresponded to actions in the iMD-VR simulation. For this study the students only needed to operate each controller's 'trigger', enabling them to exert a force on a targeted atom, and manipulate its dynamics and motion. Each student was then provided a brief overview of the series of chemical tasks that they would be conducting, and given up to ten minutes in iMD-VR to accomplish these tasks. Each student was offered an opt-out and nausea warning before they attempted the iMD-VR section, although zero students opted out and zero reported any discomfort. The three tasks which we instructed the students to undertake are shown in a video available at vimeo.com/320188113, and included the following: A. Claisen rearrangement of chorismate to prephenate via a cyclic transition state, as shown in Figure and part A of the supporting video. The reaction was conducted in a vacuum using real-time forces obtained from a semi-empirical quantum mechanical method called density functional theory tight binding (DFTB). This technique was chosen because it is one of the fastest quantum chemistry methods available, and so allows students to undertake real-time interaction with the molecules to simulate chemical reactions.