Impressively, apart from the HRMS and 1 H NMR methods, (TD)DFT calculations were also performed to further corroborate the binding mode and elucidate the Al 3+ /F --switched ESIPT process theoretically and clarify the experimental results. By utilizing the two chemical inputs (Al 3+ /F -) and dual emission outputs, a molecular memory device was established. More intriguingly, the portable, semiquantitative, precise, visualized, and on-site sensing of Al 3+ ions in water samples was achieved by a smartphone-based intelligent detection platform. What's more, NPDM was successfully employed for sensing the various concentrations of Al 3+ and F -in live HeLa cells with desirable biocompatibility and without interference from the intracellular oxidative stress. This study would lay the foundation for ESIPT-active fluorogenic tweezers with multiple functions in practical applications. Scheme 1. Schematic illustration of the ESIPT-active regenerable fluoro-chromogenic molecular tweezers NPDM was employed for Al 3+ and F -assays.