While these physical methods for predicting solubilities have received some attention in the literature, most are still in their infancy with only a handful studies applying them and it is not yet clear how broadly applicable they will be , and others have only been suggested or demonstrated in proof-of-principle tests . Our view is that the time is ripe for physical methods to predict solubility, especially given the routine nature of solvation free energy calculations at present which comprise essentially half of the solubility problem (see the Theory section). Polymorph and crystal structure prediction successes also mean that we may often have a suitable crystal structure of the compound as input , so what remains is to predict the solubility given a crystal structure and simulations of the relevant phases.