SARS-CoV-2-ΔCT pseudoviruses for various strains were produced using HEK-293T cells transfected with GeneJammer (Agilent) using IgE-SARS-CoV-2 Spike plasmid WT and Omicron variants (Genscript) and pNL4-3.Luc.R-E-plasmid (NIH AIDS reagent) at a 1:1 ratio. Forty-eight hours post transfection, supernatant was collected, enriched with FBS to 12% final volume, steri-filtered (Millipore Sigma), and aliquoted for storage at -80°C. SARS-CoV-2-ΔCT pseudoviruses were titered to yield greater than 20 times the cells only control relative luminescence units (RLU) after 72h of infection. Pseudovirus neutralization assay was set up using D10 media (DMEM supplemented with 10% FBS and 1X Penicillin-Streptomycin) in a 96well format. CHO cells stably expressing human ACE2 were used as target cells (Creative Biolabs, Catalog No. VCeL-Wyb019). For setting up the pseudovirus neutralization assay, 10,000 CHO-ACE2 cells were plated in 96-well plates in 100 µl D10 media and rested overnight at 37˚C and 5% CO2. The following day, specific amounts of lectin products were incubated with virus for 90 minutes at room temperature. Following incubation, virus-lectin samples were centrifuged at 1500rpm for 10 minutes and 50 µl/well of virus containing supernatant were added to the plated CHO-ACE2 cells. The cells and pseudovirus mixture were incubated in a standard incubator at 37˚C and 5% CO2 for 72h. Post 72h, cells were lysed using britelite plus luminescence reporter gene assay system (Perkin Elmer Catalog no. 6066769) and RLU were measured using the Biotek plate reader. Neutralization titers (ID 50 ) were defined as the reciprocal serum dilution at which RLU were reduced by 50% compared to RLU in virus control wells after subtraction of background RLU in cell control wells. Data for percent neutralization vs concentration were fitted to nonlinear regression i.e., log(inhibitor) vs. normalized response --Variable slope Least squares fit to obtain an ID50 value. All calculations were done using GraphPad Prism 8.