The effect of substituents on macrocyclic anion transporters is less explored as the preparation of a larger series of macrocycles is more challenging than for simpler anionophores. Macrocyclic anion transporters are often larger, stronger in anion binding, and more lipophilic than simple anion transporters. Examples of macrocyclic anionophores include those based on calixarenes , calixpyrroles , resorcinarenes , cyclic peptides , biotin [6]urils and aza-and thiobambusuril derivatives. However, it should be noted that only a few of these reported macrocycles have a fluorinated substituent in their structure. An outstanding example of macrocyclic anionophores are fluorinated bambusurils (BUs), which have been identified as receptors with particularly high anion affinities and as the most effective Cl -/HCO3 - transporters to date. These fluorinated BUs transport anions via mobile carrier mechanism, i.e., the complex of BU and anion diffuses through the membrane. Interestingly, the Cl -/HCO3 -antiport by BUs could be brought to a halt upon addition of the even stronger bound anions NO3 -or ClO4 -. We have also reported examples of BU transporters that contain an atypical -SCF3 group within their structure. BUs contain 12 benzyl substituents per molecule and therefore small changes to the substituent are amplified by the number of the substituents. Investigating a series of BU derivatives would facilitate the evaluation of the effect of fluorinated substituents on the anion transport properties of larger anion receptors.