A total of 313 unique lipids were annotated (Level 2-3) in the serum samples by non-target LC-HRMS analysis (Table ). Lipid pathway enrichment analysis, computed with the significant lipids, revealed glycerophospholipid metabolism and sphingolipid metabolism as the most altered pathways (Table ), which is consistent with a previous study performed in serum samples from PD and LRRK2 carriers .