We first present the results of our DLPNO-CCSD and (T) algorithms on the S22 data set, consisting of 22 dimers of sizes ranging from water-water to adenine-thymine. For a fair comparison of our algorithm, we compared the results to canonical DF-CCSD and DF-CCSD(T) as implemented in Psi4, using the same RI basis sets for the correlated computations. For these tests, we use the cc-pVDZ, jun-cc-pVDZ, and cc-pVTZ basis sets. For the unfamiliar reader, the jun-cc-pVDZ basis set adds a set of diffuse functions for all heavy atoms up to shell l -1, where l represents the highest angular momentum shell, from the cc-pVDZ basis. The interactions of the S22 dimers can be primarily hydrogenbonded (HB), dispersion-dominated (DD), or mixed influence (MX). We therefore present the results of the interaction energy errors in aggregate for each basis set, as well as for each interaction type for each basis set. All computations are performed with the counterpoise (CP) correction. The results comparing DLPNO-CCSD to canonical DF-CCSD are presented in Table , and comparisons between DLPNO-CCSD(T) to DF-CCSD(T) are shown in Table .