The solvation process for any hydrophobic solute can be imagined as a two step process. Firstly, a cavity is created to accommodate the solute. In the second step, the solute-solvent dispersion interaction is introduced. The cavity formation step is highly unfavorable and it always overcompensate the favorable dispersion interaction contribution. Now the extent of hydrophobic association in various osmolyte solutions is not same because the cavity formation contribution and dispersion contribution are different in various osmolyte solutions. It is really important to study the cavity contributions and the solute-solvent dispersion interaction energy contributions in different osmolyte solutions to get proper understanding about hydrophobic association in osmolyte solutions.