-TBK1 signaling contributes to cell survival and proliferation in various contexts. It can activate the AKT (protein kinase B) pathway, which promotes cell survival and growth, and it regulates the expression of anti-apoptotic genes. -TBK1 is involved in the regulation of metabolic processes, including glucose metabolism and lipid homeostasis. It can modulate insulin signaling pathways and influence the expression of genes involved in metabolism.