While the core mainly receives CUR at low [CUR ]=1-3 g/L, the first shell must include small amounts of CUR here as well to obtain the measured LC. With increasing CUR feed, both core and shell 1 incorporate more CUR. 𝜙 ‚ƒv in the shell reaches estimated values of up to 20-30% for all three polymers (3 and 5 g/L). Only at high polymer concentrations, the values for 𝜙 ‚ƒv become less reasonable and trustworthy, since the nanoformulations either aggregated and precipitated (A-pBuOx-A) or the particle shape becomes more heterogenetic due to the presence of larger agglomerates or worm-like structures (A-pPrOzi-A and A-pBuOzi-A). Nevertheless, the analysis of SANS data unambiguously shows that the micellar shell is involved in incorporating large amounts of CUR and plays an essential role in the stabilization process. This corroborates recent finding, where solid-state NMR spectroscopy also revealed interaction of CUR with the amide moieties in the hydrophilic corona of A-pPrOzi-A which lead to a decrease in dissolution rates at higher loadings. In addition, when the hydrophilic blocks were exchanged to the slightly less hydrophilic poly(2-ethyl-2-oxazoline), solubilization capacity of the corresponding ABA triblock copolymers for CUR and paclitaxel drastically decreased. Similarly, stabilization of CUR and paclitaxel using a methacrylate based system featuring fructose containing corona forming blocks has also been previously reported.