We propose a sieving methodology which starts from a docking performed with QVina or MOE on both full databases, from which in different stages of increasing computational requirements a decreasing number of compounds is being analyzed. All the scripts used within this methodology are available in TO BE DECIDED. Thus the search box for the docking with QVina was defined manually with the help of the UCSF Chimera program. After the execution of the four molecular docking procedures, the structures found were ordered in descending order of interaction, selecting for the next step those poses with an interaction energy better than -6,8 kcal mol -1 . Docking with MOE was performed in two steps. In the first one, after defining each pharmacophore, a docking directed to the pharmacophore of each database with no subsequent refinement (that is, each docked structure is not minimized once it has been placed in the corresponding binding site) is performed. The structures selected from the docking are subjected to a second step of docking, now asking for minimization and obtaining list of compounds sorted by interaction energy. The structures obtained in the previous step were solvated with TIP3P waters after having obtained the GAFF 42 parameters for each ligand, and underwent a minimization process of 5000 steepest descent steps. For each minimized structure, the free binding energy was calculated with both MMGBSA and MMPBSA and a consensus criterion is used to choose the 100 best structures that are among the 100 best in both MMGBSA and MMPBSA calculations.