The reacQon of model substrate 4-bromoanisole (0.8 M in toluene) with a 1:1 mixture of CO:H2 catalysed by 0.33 mol% [Pd(PAd2 n Bu)2] 26 was conducted at 100 °C under constant 5 bar pressure. We employed an Unchained Labs OpQmisaQon Sampling Reactor (OSR) to automate sample collecQon and accelerate invesQgaQon of variables through parallel experimentaQon. The OSR can aliquot from eight parallel reactors with independent pressure and temperature control. Automated reacQon sampling was combined with a streamlined approach to workup each aliquot using an Opentrons OT-2 liquid handling plaGorm for an automated filtraQon step. Subsequent data analysis was carried out using ReacQon Progress KineQc Analysis (RPKA) or Variable Time NormalisaQon Analysis (VTNA). The combined workflow allowed for approximate ten-fold reducQon of aeended hours for experimentaQon compared to established non-automated approaches (Fig 2a). ReacQon rates of 4-bromoanisole formylaQon were reproducible across all eight individual reactors. IniQal rates of formylaQon did not show a dependence on sQrrer rate (500 rpm vs 800 rpm), suggesQng that mass transfer of the gas is not limiQng in this system.