Electrostatic interactions are ubiquitous in proteinaceous systems and make an essential contribution to protein structure, folding, binding, and condensation . Proteins differ in a fundamental way from many other charged colloidal systems because their charge is not fixed, but depends through the dissociation equilibrium of constitutive AAs on local molecular geometry, dielectric inhomogeneities, vicinal charges, and solution composition. As soon as any of these parameters is changed, the protein charge responds in a process referred to as charge regulation (CR), through which the same protein acquires a different charge. CR effects are significant and have been shown to qualitatively change the phase diagram of protein solutions, including a liquid-liquid phase separation based on CR , while self-assembled protein structures appear to exhibit asymmetric constructs stabilized due to global charge redistribution .