From a broader perspective, the results presented in this work confirm the wide applicability of the JOYCE3.0 protocol, which can be reliably used to generate force field parameters that accurately describe the structure and dynamics of nearly any molecular target. This motivated us to enhance the code's usability: new automated procedures, an improved interface with widely used electronic structure programs and popular MD engines, as well as detailed support provided on a dedicated website, will facilitate users in developing their own QMD-FFs to simulate their systems of interest. On the one hand, the intramolecular term of JOYCE3.0 can be combined with an intermolecular component, making it easily adaptable for the simulation of simple solutions, complex fluids, or multi-component devices. On the other hand, the ability to generate consistent ground-and excited-state FFs (using TD-DFT, post-HF or multi-reference techniques) enables the integration of JOYCE3.0 FFs into cost-effective classical CL/QM protocols, allowing for realistic simulations of optoelectronic properties. The integration of QMD-FFs in the novel Ad-MD|gVH MM procedure proposed in the present work is probably the most striking example of JOYCE3.0 potentialities in this framework, where overcoming the structural mismatch allows for accurately predicting the spectral shape without resorting to any phenomenological broadening. As demonstrated in this work, the capabilities of this new release of JOYCE have matured to a level of general applicability, that allows it to handle a wide range of systems, encompassing both ground and excited states. This versatility opens the door to numerous exciting applications, from the rational design of advanced materials design to the study of photoinduced processes in biological as well as complex heterogeneous systems.