SMAC:lipid and SMAC:SMAC interactions were measured with GROMACS gmx mindist implementation using option -group, to count contacts with multiple beads in the first group as one. Molecular dynamics snapshots were visualized using Visual Molecular Dynamics (VMD) . Data graphics were plotted with Grace (GRaphing, Advanced Computation and Exploration of data). Figure panels were organized using Inkscape and GIMP (GNU Image Manipulation Program).