In contrast to the kinetic sensitivity, the thermodynamic sensitivity heat maps in Figure and Figure show that species' thermodynamic sensitivity over the metals can change significantly after BMA rate substitution. Adsorbed water is negatively sensitive on about one fourth of the metals which have strong oxygen bonds and weak carbon bonds (bottom right) on the CMPO thermodynamic sensitivity heat maps of CH 4 conversion, synthesis gas, and full oxidation yields in Figure . It suggests that the enthalpy of adsorbed water is one of the factors limiting the descriptor values. However, the sensitivity values on CMPO-BMA screeing results in Figure are more than 10 times smaller in general compared to CMPO models, indicating that the the enthalpy of adsorbed water does not contribute as substantially to the descriptor values.