This article presents the Cheminformatics Microservice, an open-source solution for handling chemical data and performing various cheminformatics tasks by employing multiple cheminformatics toolkits (CDK, RDKit, and Open Babel). These tasks include generating highquality chemical structure depictions and 3D conformers, calculating molecular descriptors and IUPAC names, and converting SMILES representations of chemical structures into other machine-readable formats. The microservice can be accessed through a unified REST (REpresentational State Transfer) interface, which is made available as a public server for anyone to access via api.naturalproducts.net. Alternatively, it can be installed locally or on a private server using the provided Docker image. It can also be deployed and auto-scaled on a Kubernetes-managed private cluster in just a few steps via the Helm Charts provided . These deployment options are designed to be user-friendly since they require no prior knowledge of the underlying toolkits or their setup environment. They make the presented software service suitable for a wide range of applications in academic and industrial environments. The entire Cheminformatics Microservice source code is made available to the public on GitHub: . Users and researchers are encouraged to submit feature requests and contribute to the microservice to ensure its continued growth.