The error estimation was performed using the standard deviation of the mean of the four replicas. All simulations were run using GROMACS 2022 and PLUMED2 . In Silico Titration Experiments. Six 5 µs long Aβ42: 10074- G5 MD multi-eGO simulations were performed, placing 10 monomers of Aβ42 in a 255 nm cubic box, corresponding to a concentration of 1 µM Aβ42, and adding 10, 60, 100, 200, 400 or 800 10074-G5 at random, respectively. Simulations were run using GROMACS 2022 .