Using the polarizable force field comes with a significant computational cost. While the ff19SB + OL3 simulations achieved a simulation speed of ~300 ns/day for the largest (Ago2) complex, the AMOEBA simulations only reached a simulation speed of ~4 ns/day. All simulations were run in a similar environment, on a single NVIDIA Volta V100 GPU on CSC's supercomputer Puhti. Due to this significant increase in computational cost, in some cases it might be more beneficial to use nonpolarizable force fields with an enhanced sampling method to get reasonably accurate results. The polarizable water model O3P only minorly decreased the simulation speed (~280 ns/day).