Fig. in the Supporting Information shows boxplots of the distributions of ten physicochemical properties, including those related to drug-likeness as defined by Lipinski's "Rule of Five." Table summarizes the calculated physicochemical properties and other constitutional descriptors along with their statistical metrics across the data sets. When comparing the distributions of the calculated properties against the reference set of approved antiviral drugs, it was observed that most of the analyzed compounds exhibit physicochemical properties compatible with Lipinski's Rule of Five. Exceptions were identified, most notably in compounds targeting IAV Polymerase (PA), which deviated from the drug-likeness parameters and did not match with approved antivirals data set. These deviations could be attributed to the unique structural or functional requirements of compounds targeting this specific viral protein.