Three main components are required to make such an approach successful: (1) A set of highly predictive and richly annotated rules; (2) a significant-size database of reliably available and inexpensive starting materials; (3) a chemoinformatics engine capable of combining (1) and ( ) to create a large number of MN-3 molecules, each annotated with a proposed synthetic route description as well as with predicted properties seen as important in contemporary cutting-edge drug design.