Metabolomics typically uses nuclear magnetic resonance (NMR), liquid chromatography mass spectrometry (LC-MS), or gas chromatography-MS (GC-MS) . Recent advances in instrument performance, including chromatographic separation, resolution, sensitivity, and detection speed now allow qualitative and quantitative analyses of thousands of metabolites from a sample . However, currently no single technique can identify or quantify all metabolites due to their extreme chemical diversity, their wide concentration range, and because not all metabolites are currently known. Ongoing advances in bioinformatic tools and growing public libraries of metabolite spectra are helping to alleviate some of these problems . While NMR, LC-MS and GC-MS are all used in metabolomics for diverse applications and specifically for studying yeasts , MS-based methods are generally preferred. This is because MS is more sensitive than NMR and can be easily coupled with various chromatography methods to allow separation and quantification of diverse metabolites .