When gold-aptamer-nanoconstructs disaggregate in the presence of target nucleic acid they exhibit enhanced flow properties on lateral flow membranes, due to a reduction in their physical size (Figure & 2D). Therefore, free gold nanoparticles functionalised with Sequence-B, which contain biotin, were shown to bind streptavidin doped lateral flow membranes at predetermined sites, via one of the strongest non-covalent interactions found in nature . The lateral flow device was able to detect levels of target viral nucleic acid up to 1x10 -7 M, Figure . This sensitivity is comparable to the detection limit of the spectroscopic measurement and outperforms visually inspection of colour change alone.