This case study shows how CARE can construct huge CRNs, by focusing on the Fischer-Tropsch process , which converts syngas to a wide distribution of long-chain hydrocarbons (alkanes and olefins) used as synthetic clean fuels. To this end, a Fig. provides energy trends in agreement with experimental evidence. Ru is the most active metal catalyst as it provides the lowest activation barriers among the four studied metals, and possesses a high hydrogenation activity (C-H > C-C > C-O), however its cost limits its industrial application. Nickel is the least active catalyst and prefers C-H over C-C bond-forming reactions, while Cobalt, known for its selectivity towards long-chain products, is the only metal whose mean energy barrier for C-C coupling events is smaller than the competitive C-H and C-O bondforming reactions, explaining its higher chain growth probability compared to the other metals.