Investigation of nanoplatelet silicates revealed that they exhibit enhanced interactions with the polymer matrix compared to spherical NPs, thereby exerting a more profound influence on rheological behavior. In another example, spherical liposomes were dispersed at a concentration as high as 80 mM in a HA hydrogel, and the smaller the liposome size, the larger their surface area, increasing the likelihood of interaction with the HA chains, which ultimately led to higher elasticity. The latter was also correlated on the composition of the liposomes, with anionic and PEGylated ones yielding the highest values, likely as consequence of the reorganization of the HA network due to electrostatic and steric repulsion. To meet the need of biomedical applications, hybrid hydrogels must be syringe-dispensed and must therefore exhibit a decrease in viscosity when subjected to shear forces. Then, their ability to recover their initial properties after shear removal ensures good retention at the intended injection site. Various needle sizes have been reported, often matching specific applications such as bioprinting, electro spraying, intratumoral (18G), subcutaneous (SC) (21G), and intracerebroventricular (24G) injections, treatment of infected wounds (26G), administration into the epicardium (angiocatether secured with a 28G needle) and the inner ear (29G). Injectability must correspond to the forces that can be applied by healthcare professionals, with the yield strength remaining below the compression stress applied during injection. Importantly, attention must also be paid to an excessive crosslinking that can render the material overly brittle or stiff, compromising its suitability for injection. In addition, when injecting hydrogels loaded with cells, the applied forces must align with cell viability considerations, consequently influencing the selection of the needle size.