For instance, the fluorescence of the ATP/AzoDiGua supramolecular aggregates was successfully and dynamically controlled by various physical (light), chemical (metal cations) and biological (enzyme) stimuli. This not only further evidenced the dynamic control over the self-assembly achieved by these different stimuli but also provides opportunities for the development of sensing strategies for detecting ATP, analyzing the presence of metal cations with valence-selectivity, or assessing enzymatic activity. Demonstrated here with two particular bricks, ATP and AzoDiGua, we think this co-assembly strategy could be explored with other nucleotide or DNA/RNA targets and/or other stimuli-responsive DNA intercalators to build highly dynamic and multifunctional supramolecular structures in a particularly robust, userfriendly and multi-purpose way.