Using transaminases (Figure ) and alcohol dehydrogenases (Figure ) is a conventional biocatalytic strategy to produce chiral amines and alcohol, respectively . Most industrially relevant transaminations suffer from unfavorable thermodynamics, and transaminases tend to be inhibited by their keto substrate (amino-acceptor) and by-products. To achieve high transamination yields while avoiding transaminase inhibition, in situ (co)-product removal and/or controlled substrate addition can be performed using membrane technologies . One possible strategy is the use of pervaporation to remove acetone (i.e. the most common co-product of transamination reactions). Pervaporation is especially attractive for the temperature-sensitive processes because it can be operated at moderate temperatures. Dejonghe et al. implemented a hydrophobic pervaporation at the outlet of a transamination reactor (employing free enzymes) in order to remove the acetone by-product from the biocatalytic system. A PolyDiMethylSiloxane (PDMS) membrane module was used as pervaporation unit. Such transamination coupling with pervaporation resulted in a 13% increase in product yield after 9 hours of reaction, compared to the standard transamination process (where no pervaporation was performed). However, it was also observed that the effect of acetone removal by pervaporation is minimal at low acetone concentrations (in the biocatalytic system). This highlights the need to work at high substrate concentrations and possibly to couple pervaporation to another product separation technique (which would allow to primary push the transamination towards high product yields). This other product separation technique should target the amine product, and may be also performed via membrane technology (e.g. via membrane-extraction). Notably, Dejonghe et al. conducted the flow asymmetric synthesis of 1-methyl-3-phenylpropylamine (MPPA) from benzyl acetone using free ATA-v2 mutant enzyme in organic solvent (n-heptane), and employed polypropylene (PP) membranes contactor for the in situ amine product removal. An acidic aqueous solution (pH = 3) was used to efficiently extract the amine product via membrane-assisted extraction. In this study, the use of an organic solvent as reaction medium was found beneficial in the sense that it allowed to increase the optimal keto-substrate concentration (by 2.5-fold with respect to its aqueous solubility) without triggering inhibition. This approach resulted in a significant increase in terms of final product yield (i.e.