We here implemented this concept using a diblock copolymer: poly(2-(dimethylamino)ethyl methacrylate)-block-poly[poly(ethylene glycol) methyl ether methacrylate)], poly(DEAEMAb-PEGMA), where the amine-rich polyDEAEMA becomes hydrophobic to form a micelle core at c. pH7 . The polyPEGMA block forms a bottle-brush structure that is highly stabilizing. Because nanoparticles are produced already stabilized within these micelle structures, synthesis can be carried out at very high concentrations without loss of stability.