From a synthetic perspective, coupling to the cavity flips the selectivity expected for electrophilic aromatic substitution in two important and useful ways. First, it flips the normal selectivity of the nitrogroup to make it an ortho-/para-director. Second, this approach appears to stabilize ortho-substitution over para-substitution. As noted above, this is also a rare selectivity that would complement existing approaches well. Overall, this work demonstrates the possibility of polariton-mediated changes to the selectivity of well-known chemical reactions. The theoretical prediction can, in principle, be experimentally verified using state-of-the-art plasmonic nano-cavity designs.