In COCONUT, each natural product is assigned a score (annotation score, see to indicate its level of annotation. The scoring algorithm evaluates a molecule by assigning scores based on the presence and quantity of key attributes, such as literature references, taxonomic provenance annotation, CAS number, synonyms, names, and data sources. It then calculates a weighted total score, scales it, and rounds up the final score to the nearest integer for standardised assessment (1 star is the lowest quality annotation, while 5 stars is the highest quality). A histogram of the annotation score value distribution in COCONUT 2.0 is given in Supplementary Information (Supplementary 2).