Based on the following criteria, a shortlist of 19 compounds was subsequently selected for assessment by experts: (i) compounds must be easily synthesizable within resource constraints; (ii) compounds must be likely stable, e.g., with functionality represented in marketed compounds; (iii) only one representative per core (i.e., His115/Ser111 alternative binder), with left-hand side (LHS) and right-hand side (RHS) decorations, was allowed; (iv) some chemotypes were excluded based on free energy calculations. After rank-ordering of the compounds by experts, a final compound list with consensus ranking was established for synthesis.