The same polymers described for the formulation of the hydrogel matrix (Figure ) have also been widely adopted for the synthesis of dispersed nano-objects such as NPs, micelles, nanogels and dendrimers. While polymer nanocarriers were primarily intended for intravenous (IV) administration, their integration into a hydrogel matrix has been proposed for localized drug delivery near the target site. The objective was to increase the drug bioavailability and thus obtain optimal pharmacological activity while minimizing systemic toxicity. In locoregional administration, considering the generally low injected volume and the aim of achieving prolonged therapeutic action, drug and nano-object loading values play a key role.