The results show that the median CPU time requirements of the RegioSQM20 method is 48 s per molecule on four Intel(R) Xeon(R) CPU E5-2643 v3 @ 3.40GHz cores. The RegioML model is almost 100 times faster on just a single Intel(R) Xeon(R) CPU X5550 @ 2.67GHz core with a median CPU time of less than half a second per molecule. The WLN architecture is able to achieve a mean CPU time of just 0.03 s per molecule on the single Intel(R) Xeon(R) CPU X5550 @ 2.67GHz core. The main reason for the slower performance of RegioML is the GFN1-xTB single point calculation needed to compute the atomic charges.