All 68 compounds were initially screened in four replicates at eight concentrations ranging from 515.6 nm to 66 µm. We defined compounds whose median % inhibition at 33 µm was at least 50%, the same threshold used for the AMS screen, as initial hits. We repeated the dose-response curve screens for two additional rounds of ten compounds each, expanding the range of concentrations tested to improve the quality of the curve fits (Appendix A.9). We defined confirmed hits as those with a dose-response curve in curve class 1.2 or in curve class 2.2 with an IC50 95% upper confidence limit within the tested range of concentrations. We used the Collaborative Drug Discovery Vault software to fit dose-response curves, calculate IC50 values and the 95% upper and lower confidence limits, and define curve classes. A Supplementary Methods