The TSE has significant fibril-like structure. We performed guided MD-simulations with the experimental Φ-values as constraints to generate a structural representation of the TSE. These simulations generate a self-consistent TSE that fulfils nearly all of the experimental constraints. Interesting features of this TSE are a large degree of amyloidlike structure (ca. 30%), as well as the existence of a 'misfolding nucleus' (residues 49-62).