After 1000 ns, every hydrophilic NP in the dispersion in C4 is in contact with at least one other NP, and most of them present at least 2 neighbors after 2500 ns (structures in the middle and right of Figure , where NPs were colored differently according to the number of other NPs in contact to them). In this system, even before 800 ns almost all the particles are bonded into a single cluster (be aware of the periodic boundary conditions when looking at those structures: