DiffDock-L reports a confidence score for each generated docking pose that quantifies the likelihood of a pose having an RMSD of less than 2.0 Å to the hypothetical measured binding pose. This confidence score is ligand-specific and can only be used to rank poses of the same ligand. To enable VS, we supplemented DiffDock-L's pose sampling and scoring capabilities with the Vina scoring function (from the AutoDock Vina package ) and Gnina scoring function. The two scoring functions are among the most popular representatives of classical and DL-based scoring functions, respectively.