Atomistic molecular dynamics (MD) simulations are a widely used and highly valuable tool to reason on biomolecular structures and dynamics. Especially among industrial users, the MD engine Desmond by Schrödinger, Inc. has become a popular choice due to its simple user interface. Its proprietary force fields are, however, not widely independently validated; this applies also to its latest all-atom force field, OPLS4. Here, we tested the validity of OPLS4 against atomic-resolution experimental data and contrasted its performance to another industry standard, CHARMM36.