Selective C-H functionalization plays an important role in the synthesis of bioactive natural products , drug metabolism , pharmaceutical industry , DNA repair , and transcription . C-H bonds can be functionalized in various ways, including but not limited to cyanation , oxidation , hydroxylation , epoxidation , and halogenation . Activation of unreactive C-H bonds typically requires harsh conditions due to the high C-H bond dissociation energy and its inert nature . While C-H halogenation is widely used, C-H fluorination is a difficult process, oftentimes requiring special safety equipment and highly reactive reagents . Despite the difficulties, several studies were carried out to understand C-H fluorination since it might play a crucial role in drug development .