Table : Product distribution as a function of mixer type and flow rate. As is seen in entries B and C of Table and in agreement with the literature, a 500 μm bore Tee mixer shows lower consumption of bromoanisole 1 at a given flow rate compared to a smaller (250 μm) bore tee piece. Among the other mixer designs studied, the arrow and Y type mixers also exhibited low consumption of bromoanisole 1 at a relatively high flow rate (entries A and D), while the T-29 herringbone mixer had pump stall and back-pressure issues across the flow rate range under study, rendering the mixer impractical for our purposes (entries F, I and K). Interestingly, the HTM-ST chicane mixer performed consistently well across all flow rates (entries E, H and J) but a deterioration in mixing quality was suggested by the presence of some starting material at an ArBr flow rate of 1.063 mL min -1 ; this is despite the longer lithiation residence time (entry J).