Presumably, the other TPU-based moldable plastics will not cause acute toxicity to zebrafish embryos based on the results for JXE JXO moldable plastics. Nonetheless, this possibility does not dismiss their potential to elicit bioactivity and cause sublethal effects, as polyurethanes have been shown to leach bioactive compounds. Further evaluation of TPU-based moldable plastics, particularly those sold for dental applications, is warranted.