Initially we test active learning for virtual screening (VS-AL). In agreement with previous studies we obtain a substantial increase in oracle efficiency compared to brute-force screening, recovering 42±4.0 and 35±4% of hit molecules with only 5000 oracle calls (Figure ), for a hit rate of 0.25% and 2.54% in 5000 oracle calls for ROCS and docking respectively, a 7-11 fold improvement. The VS-AL recovers all hits within 8927±1750 oracle calls for ROCS and 82% of hits (~314) after 30 000 oracle calls for docking. Generative models (RL, RL-AL)show exponential growth in the number of hits found between 10 000 and 30 000 oracle calls. By 30 000 calls, both RL systems have generated more hits than those contained in the virtual library (30 hits out of 100 000 total compounds).