Computational studies on these systems have commonly employed implicit solvation models, neglecting the potential solvent stabilization of intermediates. Liu and co-workers applied AIMD using the PBE/TZVP level of theory to explore the glycosylation reaction of a glucosyl trichloroacetimidate donor with different alcohol acceptors in DCM, acetonitrile and methyl tert-butyl ether. Their work revealed that the preferred pathway is solvent-dependent and confirmed the key role of solvent in stabilising the oxocarbenium intermediate. The reaction was also investigated experimentally by Seeberger et al., who demonstrated that stereoselectivity remains unaffected by the leaving groups but varies across different solvents.