The results commented above should be taken as preliminary because only one target / parent pair, one run for estimating stochastic variations and preference criteria. Within those limits, the Toxicity Risk value of 1 was chosen for the rest of the work with other target /parent pairs, since it generated ~ 2.6 fold higher number of NTN children than without Toxicity Risk (Figure ). For the following DW-BEL work, variables predicting a high number of children were preferred.