Here, we focus on planning RBFE calculations, an area where the field typically uses one of several tools to plan maps. Typical tools use a heuristic decision-making process. For example, the tool Lead Optimization Mapper (LOMAP) tries to find the minimal number of edges where every node is in at least one cycle and edges are removed from regions of the graph with many connections . This design strategy results in maps with an edge count typically between (1𝑛, 2𝑛). The OpenEye tool, OE Mapper, also follows this design goal and minimizes the edge number while maintaining cycles (OpenEye Scientific, 2021). Some design approaches entirely avoid solving the challenge of design selection by choosing maps with a fixed topology , sacrificing potential accuracy in favor of simplicity.