The main motivation for the design of the AdSoS scheme is a performance improvement following from a large reduction in the number of solvent molecules in the system. This speed gain is reflected by the simulation timings, which are shown in Fig. as a function of the number P of processors. Note that the FG, CG, and CG+B scheme share the same box size, but the AdSoS systems differ from the FG system in the number of molecules.