We applied an analogous method to obtain 1-(2-hydroxyethyl)quininium bromide, which to our knowledge has not yet been described previously. However, the introduction of a hydroxyl moiety into the substituent significantly altered the properties of the finished product, thus it was necessary to modify and develop a new method for purifying the reaction mixture to remove the resulting quinine degradation products. In the first stage of purification, the postreaction mixture was slowly introduced into the ethyl acetate, which acted as an anti-solvent.