Alternatively, Newton-X NS allows employing AMOEBA 102 forcefield to simulate environmental effects using a fully polarizable electrostatic description. In this scheme, each atomic site of the environment is represented using a set of fixed electrostatic multipoles (up to quadrupoles) and isotropic polarizability. As a response to the electric field generated by the QM density (and the fixed multipoles of the environment), the presence of isotropic polarizabilities leads to a set of induced point dipoles that, in turn, affect the QM density. This mutual polarization between the QM density and the environment enhances the completeness of the environment's response with respect to an electrostatic-only model. It is expected to be particularly important in the description of light-induced processes. At present, TDDFT simulations can be coupled with AMOEBA forcefield, using a previously developed interface between Tinker and Gaussian. The current implementation of surface hopping with TD-DFT/AMOEBA has been tested using the example of the water photo-oxidation of pyrimidine. Even if the method is still at the beginning of its development, we expect to provide a valuable framework for studying the photochemical processes of molecular systems in solution or embedded in more complex biological or artificial matrices.