Table . Two consistently well-performing pK a prediction methods based on consistent ranking within the top three according to various statistical metrics. Ranked submissions were ranked/ordered according to RMSE, MAE, R 2 , and Kendall's Tau. Many methods were found to be statistically indistinguishable when considering the uncertainties of their error metrics. Additionally, the sorting of methods was significantly influenced by the metric that was chosen. We determined which methods are repeatedly among the top two according to all four chosen statistical metrics by assessing the top three methods according to each metric. Two QM-based methods consistently performed better than others. Performance statistics are provided as mean and 95% confidence intervals. All statistics for all methods are in Table .