Fig. Methods and approaches that can be incorporated into an integrated catalysis toolbox. Emerging spatial and temporal control approaches, such as heterogeneous catalysis, can be included to solve the compatibility issue between different catalytic cycles. As a complement to artificial catalysis, biocatalysis can grant the integrated system exquisite selectivity. When implementing integrated catalysis, reactor design can be crucial for the overall system to achieve high efficiency. In addition to experimental efforts, computations can expedite the screening of reaction conditions and identify the optimum route for the synthesis of complex organic compounds with high value.