In contrast to the LEUS approach, which relies on a damping of the build-up rate after each double-sweep of the entire range during the LE phase (similar to well-tempered metadynamics 107 ), the present scheme relies on a constant build-up rate in the LE phase (which leads to oscillations in the weights). The biasing potential for the US phase is then defined by averaging the weights over a certain period at the end of the LE phase.