Next, further extension of this phenol synthesis protocol to cyclohexenones was examined (Scheme 3). 2-Aryl substituted cyclohexenones, with different substituent groups on the benzene ring were good substrates for this photocatalytic dehydrogenative reaction, affording corresponding 2-arylphenol products (16, 36-39) in 63-71% yields. Diverse 3-aryl substituted phenols (40-45) were also obtained in moderate yields via the dehydrogenation of corresponding 3-aryl cyclohexenones. Additionally, 3,5-disubstituted phenols (46-56) could be obtained from cyclohexenones in synthetic useful yields. It is noteworthy that 3,5-disubstituted phenol derivatives are ubiquitous core structures for many bioactive molecules, yet are inaccessible by electrophilic aromatic substitution of phenols. The structure of 51 was ambiguously confirmed by X-ray diffraction analysis. To further demonstrate practicality of the protocol for the synthesis of phenols, the reaction was scaled up to 2.0 mmol scale using 4-acetoxycyclohexanone 1e, delivering corresponding phenol 6 in 78% yield (Scheme 4a). Next, the reaction of 3,5-diarylsubstituted phenol product 47 with cyclopentyl isocyanate afforded biologically active compound LUF5771 in 76% yield (Scheme 4b). Scheme 4. Scale-up and application experiments.