A screw is a simple chiral object that couples rotation around one axis with displacement along that axis. This displacement is perpendicular to the plane of rotation and is characterized by the screw's pitch (or lead). Here we define pitch (P) as the perpendicular distance advanced by a screw in a 2π-revolution (See Fig. ). In a lab-fixed frame, left-and right-handed screws have pitches with the same magnitude, but with flipped signs, rotating in opposite directions to do the same task. This concept can be easily extended to chiral molecules by considering the translation-rotation coupling tensor in Eq. (1). In a medium which induces rotation of molecules (as in a vortex flow), chiral molecules will translate in opposite directions. As a consequence, this asymmetry may enable the resolution of the enantiomers. In the following sections, we develop a hydrodynamic framework to rapidly estimate molecular pitches, as well a competition model for the separation of chiral molecules in solution. We note that the molecules do not need to display screw-like geometries for this separation method to be effective.