The comparison of the 2 clearly show a large grouping near the highest binding epitope in the case of P197 as these are small RMSDs and a large number of RMSDs in the range A. In the case of S197 most of the 500 docking runs are widely different than the highest scoring ligands; the RMSD is not directly connected to nor the same as binding interaction. Chlorsulfuron has become strongly delocalized in the P197S mutation with RMSDs in a range of Angstroms.