Before combining all bi-dimensional representations of chemical spaces, each representation was constructed using KNIME software v. 4.3.4 and the module "t-SNE" which is widely used to reduce high-dimensional data to two dimensions . In t-SNE, the parameters were: 1,000 iterations, 0.5 theta value, and 30 perplexity values to generate t-SNE 1 and t-SNE 2 coordinates.