Sheet-like crystal packing is less favored by most of the molecules. This packing type corresponds closely with cluster 1 from the clustering analysis (red cluster in Fig. ) and is mainly concentrated in the top/right-hand-side of the sketch-maps, which dominates the crystal pack-ing landscapes for molecules 5, 12 and 16. The crystal packing similarities among these three molecules could be largely attributed to the similarities in their molecular structures -within the molecule, hydrogen bond donors and acceptors are located close to each other on the convex side of the molecule. The herringbone packing motif is so infrequent across the crystal structure landscapes that it is not classed as a cluster by the HDBSCAN* approach.