There were 14 such ligand pairs for which we increased the ensemble size to 10. Figure compares the results from ensemble sizes 5 and 10 for all these cases. We observe a substantial improvement in the overall accuracy for this set of 14 ligand pairs simply on increasing the ensemble size to 10 which can be attributed solely to better precision. MUE improves from 2.07 ± 0.41 kcal/mol to 1.65 ± 0.42 kcal/mol and r p increases from 0.28 ± 0.34 to 0.33 ± 0.35.