Confab was used to enumerate systematically all conformers for each molecule using the 'torsion driving approach'. Confab iterates systematically through a set of allowed torsion angles for each rotatable bond in the molecule. Being a systematic search, Confab was thus expected to identify all the low energy conformations for each molecule. However, the best torsion angles may not be covered by the set of the torsion angles used in Confab. On the other hand, BOA samples torsion angles freely in the space and learns from the observed conformations, which enables it to recover conformations with lower energies using orders of magnitude fewer evaluations than Confab.