N and ∆d N . This comparison to C ref can be repeated for cluster-sets generated from datasets of increasing N , and evolution of ∆F N and ∆d N with growing N can thus be assessed. Once datasets are large enough, the positions and relative free energies of minima would be expected to be independent of dataset size. The results of this analysis on the case of alanine dipeptide are shown in Figure ,g,h.