Liquid ̶ liquid extraction (LLE) is a common unit operation in synthetic isolation owing to its scalability and costeffectiveness that arises from the preferential solubility of compounds in two immiscible liquid phases. However, automated LLE is challenging due to complex mixtures and potential issues such as emulsions formation, stable dispersions, and rag layers that increase separation times and slow process scale-up. As such, designing and optimizing LLE is a labor-intensive trial-and-error process, requiring extensive experimentation to determine conditions selections (e.g., solvent identity).