For context, this publication provides details on the methods and analysis of more than 250 data points for the pH-solubility (pKa) portion, and slightly less than 1,000 data points for the logD portion. The 96-well MTP plates contain 1 mL vials according to the layout in Figure . A target of 1 mg of drug substance was weighed into 1 mL 96-well plate vials using a Mettler-Toledo Quantos QX96 automated powder dispensing platform (Mettler-Toledo GmbH, Greifensee, Switzerland).