Another example where methods have difficulties in recognizing weak binders is with TEETOA-G3. As discussed previously, there was no clear evidence of binding observed experimentally for TEETOA-G3 at the detection threshold via ITC or H-NMR, indicating that the Δ would be more positive than -0.95 kcal/mol. None of the ranked submissions predicted this correctly. In fact, the computed binding free energies for TEETOA-G3 were all too favorable. The computed Δ ranged from -1.42 to -7.17 kcal/mol.