Later, a cellulose acetate (CA) membrane was developed by Arakawa et al. as an interference rejection membrane on a glucose sensor for measuring glucose in saliva. The team successfully measured glucose in saliva in vivo without any pretreatment of human saliva. They created a mouthguard (MG) glucose sensor to monitor salivary glucose, which has been reported to correlate with blood glucose levels. Salivary components, such as ascorbic acid (AA) and uric acid (UA), can interfere with the accurate measurement of glucose concentration in human saliva. The researchers prepared CA-coated electrodes to investigate the interference rejection membrane.