Moreover, the different correlation is consistent with the observation mentioned in Section 3.2, that some dissociations found in CTY-TAD are induced by its basin confinement technique, hence, they are observed with less calculation time than expected from their activation energy. In fact, reactions R16, R17, and R11 all of which have activation barriers above 100 kcal mol -1 are found in one of CTY-TAD's parallel simulations within only six minutes of calculation time.