Through careful isothermal titration calorimetry, quantitative 1 H NMR measurements, and a modified Ising model, the impact that nanocrystal size has on the inter-ligand interactions in the organic ligand shell was studied. Measurements indicate that as the size of the nanocrystal decreases, inter-ligand interactions also decrease. This effect is likely due to increased distance between isotropically distributed ligands. Further evidence was produced that longer, straightchain aliphatic ligands result in a more ordered ligand shell than shorter, or bent, aliphatic ligands, as indicated by the phase transition term that was required for self-consistent fitting of the modified Ising model. Additionally, X-ray diffraction measurements were able to reveal the ordered structure of the organic ligand shells in dried nanocrystal powders as well as in liquid samples of nanocrystals.