In Tables and we summarize the molecular dynamics solvation-free energy calculations of vitamin D2 and D3, respectively, in water and a representative polar protic (ethanol), polar aprotic (butanone), and non-polar (cyclohexane) solvent. As described earlier, the total solvation-free energy (non-interacting to fully interacting solute), ΔGsolv, , is written as a sum of an electrostatic contribution resulting from solute-solvent intermolecular electrostatic interactions (full Lennard-Jones and no electrostatic to full electrostatic), and a Lennard-Jones (LJ) contribution (non-interacting to full Lennard-Jones and no electrostatic interactions). The electrostatic contribution captures association and long-range interactions between the solute and solvent, while the LJ contribution accounts for cavity formation, and short-range dispersion and repulsion interactions. In our discussion of solvation-free energy, remember that the solvation-free energy corresponds to the transfer of the solute from a noninteracting ideal gas state to a solution at the same molar density. Therefore, the lower the solvation-free energy the greater the affinity of the solute for the solution.