Generally, for the hydrogenation reaction, there are two hydrogenation technology methods: batch mode and flow reactor. In the batch reactor process, although high flexibility and high efficiency can usually be achieved under optimal conditions, gas/liquid/solid multiphase mixing is problematic, especially on large scales . In addition, the H2 used in the hydrogenation process is a highly flammable gas that forms explosive mixtures with air in a wide range of concentrations. Therefore, in academic laboratories and industrial environments, handling the smallest and therefore the most penetrating gases is a big safety issue. Therefore, in order to avoid the inherent disadvantages of batch reactor methods, alternative flow reactor methods have been developed . In this case, the flow reactor method means that two or more reagents are continuously pumped into the reactor to mix and react under precisely controlled conditions. This method has many advantages: accurate reaction parameters, good multi-phase mixing, automatic control, good reproducibility, and more importantly, high safety . The flow system can monitor and control the reaction process in real time, start or stop the reaction at any time, and can add raw materials during the reaction process, adjust the flow rate to control the reaction time as a flexible, controllable, convenient, and efficient reaction system. In particular, the implementation of continuous process practices in the pharmaceutical industry is considered to be one of the most strategically significant areas for innovation in green manufacturing methods . However, the use of flow reactors is not without challenges. In flow reactor hydrogenation, the currently used fixed catalysts may need to be significantly improved to provide good conversion efficiency and selectivity. In addition, solid blockage and multi-phase mixing in small-sized channels may affect or even completely stop the desired reaction. Therefore, the preparation of new catalysts and the optimization of flow conditions have become an indispensable challenge in the development of flow reactor hydrogenation.