For example, a typical choice is partitioning the solutesolvent electrostatic interaction, el (Eq. 3) from the solute-solvent LJ (van der Waals) interaction, vw (Eq. 4). Here, we refer to the vw state as DS 0 , and describe it as the hydrophobic limit of DS -since it lacks any net charge or dipole moment. Note that the el state corresponds to a solute composed of bare charges without any close-range repulsion, and is therefore unstable and isn't directly simulated.