Diffusion is significantly impacted by the nature of the tissues-whether it is the dense compact bone or the more porous trabecular bone . This process is critical in the distribution of nutrients, waste products, and signaling molecules within tissues. In the synovial joints, for instance, nutrient delivery and waste removal are driven by diffusional processes across the synovial membrane . Age-related or disease-induced changes can alter these diffusion pathways, exacerbating conditions like osteoarthritis . Additionally, the ensuing chemical reactions are essential for metabolism, tissue repair, and cellular signaling. The diffusion and subsequent reaction of calcium ions are pivotal in muscle contraction and bone remodeling. In musculoskeletal disorders, alterations in diffusion can contribute to tissue hypoxia, inflammation, and impaired repair processes. For example, in osteoarthritis, decreased diffusion of nutrients and oxygen to cartilage due to matrix degradation can exacerbate chondrocyte death .