To gain more insight, and to improve these potential antimalarials, further iterations of these models are needed. The open nature of the competitions and of the over-arching consortium is that anyone may work on improvements since everyone has access to all the data, making this a "living" research project. A potential explanation for the predicted hit rate not being higher is the relatively small dataset (~400 compounds) from which each model was developed, potentially compromising perfectly reasonably computational approaches yet representing a fairly typical situation for lead optimisation. Two further points are of particular note: 1) It was possible to involve leading experts from the private sector in an open competition to solve a public health challenge without those participants needing to compromise their competitive business advantage; indeed success in such an endeavour has been used as an open demonstration of capabilities .