Another characteristic feature of PD is the accumulation of abnormal protein aggregates known as Lewy bodies within neurons of PD patients. Lewy bodies, considered a pathological hallmark of PD, primarily consist of misfolded α-synuclein protein and are found in various brain regions, including the substantia nigra and other structures involved in motor and cognitive function. The presence of Lewy bodies is thought to contribute to neuronal dysfunction and degeneration, although the exact role they play in the pathogenesis of PD is still under investigation. α-Synuclein aggregation and deposition are central to the pathogenesis of Parkinson's disease. 107-109 α-Synuclein is a presynaptic protein involved in regulating neurotransmitter release. In Parkinson's disease, α-synuclein misfolds and aggregates into insoluble fibrils, forming Lewy bodies and Lewy neurites. This pathological accumulation of α-synuclein is believed to contribute to dopaminergic neuron dysfunction and degeneration.