Compared to the standards, benzoyl mangiferin exhibited superior activity in the p-NDA, lipid peroxidation, and alkaline DMSO method. The activity benefited with the substitution of acetyl and benzoyl groups for mangiferin. These findings led to the selection of acetyl and benzoyl mangiferin (1, 3) in addition to mangiferin for comparison of their in-vivo and antiinflammatory properties.