In the annotated IIN-FBMN from the six newly obtained extracts, after feature alignment a total of 2,639 features were deconvoluted among the extracts, and this number was reduced to 1,990 collapsed features after IIN grouping, with 680 of them corresponding to an IIN unique molecular species (i.e., at least two correlated adducts/in-source fragments detected). The IIN-MN clustering (cosine and adducts links) returned a main cluster of 1,014 nodes containing most of the compounds of interest (See Fig. for this main cluster and Supp. Fig. for the whole MN). Among the 1,990 features of the whole MN, at the NPClassifier superclass level, 391 were annotated as flavonoids, 297 as isoflavonoids, and 134 as coumarins by CANOPUS (Fig. A and Supp. Fig. A) . At the more scaffold-specific defined NPClassifier class level, the main classes are flavanones (141 features), chalcones (123), and rotenoids (116) (Fig. B and Supp. Fig. ), with coumarins not appearing in the top 3. This analysis at the chemical class level confirms that the selected extracts are rich in rotenoids and other (iso)flavone derivatives, as expected from the ENPKG results. Using standards, we could also unambiguously identify rotenone and deguelin in the MN (Fig. ).