An overview of the fragmentation process is shown in Fig. . The Fragme∩t code loads molecular systems, generates primary fragments, and then iteratively generates and screens auxiliary fragments to build the PIE-DAG that was described in Section II A. Fragme∩t also includes code capable of running up to 60 separate electronic structure calculations in parallel, and interfaces with Q-Chem, PySCF, NWChem, ORCA, GFN-xTB, and MOPAC. Calculations reported here were performed by interfacing to Q-Chem for the DFT and RIMP2 calculations, and to GFN2-xTB for energy screening.