Methane, the second-most prominent greenhouse gas (GHG), contributes to approximately 16-20% of global GHG emissions 1 . Converting methane to valuable chemicals (e.g., methanol) is seen as a key strategy to reduce methane emissions and therefore has great environmental significance and potential economic value. However, the direct conversion of methane to methanol is particularly challenging due to the high energy required to activate the strong C-H bonds of methane, which requires an efficient catalyst to lower the energy barrier, together with the thermodynamic favorability of methanol overoxidation to CO2 . The optimal catalysts for methane-to-methanol conversion need to satisfy numerous criteria, driving an exhaustive search of catalytic materials . Enzymes (e.g., Fe(II) active sites in TauD ) have demonstrated the capability to selectively oxidize substrates with strong C-H bonds and motivated bioinspired design of synthetic systems, including both homogeneous and heterogeneous catalysts, for direct methane-to-methanol conversion. Although there has been substantial progress, no synthetic catalyst can simultaneously achieve as high activity and selectivity as enzymes, motivating a more extensive search for alternative catalysts.