The question of optimal design strategies for inhibitors and precursors, particularly their combination for a given GS/NGS pair, remains unresolved. While some approaches exist, no general concept has yet emerged. Future efforts should focus on modeling a broader range of systems and critically assessing the factors influencing selectivity. A detailed understanding of these systems, such as through electronic structure analysis, is needed to uncover the principles governing growth and blocking. Currently, there is no consensus on which blocking mechanisms inhibitor-based approaches should prioritize. Both chemical passivation and steric blocking appear necessary for effective inhibition, but the optimal balance remains unclear. It is also unknown whether inhibitors should target both mechanisms simultaneously or maximize one for a given system. Since inhibitor layer decomposition is a key factor in selectivity reduction for AS-ALD, further studies are essential in this area.