First, we simulate a system of Lennard-Jones particles in a box with Lennard-Jones walls (Supporting Information, Figs. and). Fig. shows that larger particles with large attractive forces toward each other relative to the walls It is intuitively expected that particles that outcompete the attractive forces from the wall eventually attract each other to form clusters. We observe that when large particle-particle attractive forces were set for larger particles, they form clusters inside the box within the 20 ns time frame of our simulations (Fig. and Supporting Information, Figs. and). Also when the volume of larger particles increases significantly while the energy-related parameters are the same for both types, the entropic and energic forces for accumulating the large particles next to the walls outcompete the energy and entropy for aggregation of clusters. Flat walls of the box can represent the surface of an enormous particle that strongly contributes to the entropy in attracting the larger particles in a binary mixture system (Fig. ). We systematically changed the wall-particle and particle-particle attractive forces to dig more into the influence of energy on the distribution of particles inside the box. We understood that walls with lower wall-particle attractive forces relative to the particle-particle attractive forces lead to the distribution of particles in the box. In contrast, high wall-particle attractive forces relative to particle-particle attractive forces lead to the accumulation of particles next to the wall -entropic forces along with energic forces favor this event.