S. mirabilis P8-A2 produces azodyrecins as major metabolites. While investigating the biosynthesis of azodyrecins, we inactivated azdB, which catalyzes the formation of the azo-moiety in azodyrecin biosynthesis . In addition to the accumulation of azodyrecin-precursors, we also identified the production of several unrelated compounds, identified as pepticinnamins, including the previous reported pepticinnamin E (1) (Figures ) and several new analogues (2-4) (Figures ). Obviously, the inactivation of the azodyrecin BGC impacted the specialized metabolite regulatory networks or diverted the metabolism flux toward pepticinnamin production. All four peaks displayed similar UV profiles with a maximum absorption at 225 and 282 nm, respectively. Dereplication through Reaxys and The Natural Product Altlas