It has been previously shown that the number of rotatable bonds in a ligand significantly influence the ability of a scoring function to select the best RMSD value for a given complex . Since the number of ligand fragments is more indicative of CANDOCK's performance due to its fragment-based nature, we present the selection rate of the RMR6 scoring function as a function of the number of fragments in a ligand (Figure ). Recall that the selection rate is defined as the percentage of the docked poses within For ligands with 6 or fewer fragments, the semi-flexible (Figure ) and fully-flexible (Figure ) methods perform similarly well. Thus, there is no need for full-protein flexibility for smaller ligands. This is most likely caused by the plateauing of generated poses for ligand with >5 fragments for 'Top Percent' values greater than 10% (Figure ). This plateau means there is an upper limit to the sampling space possible for a given binding site and once this threshold is reached, the algorithm is no longer able to produce enough poses. The increased flexibly allows this methodology to maneuver the ligand into its binding pose, leading to a greater selection rate.