There have been closed-source projects like CLiDE or the recently published MolMiner that combine a segmentation step with an OCSR step in their workflow. CLiDE is a fully commercial tool, MolMiner permits limited access to registered users and offers unlimited access to users who wish to obtain an enterprise licence. Since the source code of these applications is not openly available, researchers cannot adapt them according to their needs or integrate them into their applications. As all DECIMER components and the DECIMER.ai web application are open-source projects, continuous further development with significant community-driven improvements can be expected in the future. There have been major advances in the extraction of chemical information from documents. For example, ChemDataExtractor 8,40,41 has been used extensively for the automated generation of chemical databases . Perspectively, it would be interesting to integrate such applications in DECIMER.ai to mine chemical information from the text of PDF documents and link it to structural information obtained from OCSR. Although there are many more challenges to overcome to mine all types of chemical information from the literature using a single platform, DECIMER.ai may become a solid open basis for further development.