Variation from the standard conditions Yield(%) Subsequently, reactions of various quinazolinones and acetylamines were examined with the established reaction conditions, and results are summarized in Table . Firstly, we tested the reactivity of substituted quinazaolinones. In general, a variety of quinazolinones were evaluated and well-tolerated in this reaction with 2a, all reactions worked efficiently with good to excellent yields (up to 84%). Among them, we found that the halogenated substrates were smoothly carried out to afford the corresponding products in good yields, and no significant difference was found when substrates with different position of halogen on the benzene ring of quinazolinones (3ba-3ha, 63-81% yield). While trifluoromethyl substituent 3ia was obtained in 66% yield within 48 h. For electron-donating substrates on the benzene ring of quinazolinones, reactions also proceeded successfully to give the desired products 3ja-3na in 51% to 65%. Dimethyl substituent 3na was afforded in yield of 51%, perhaps due to the electronic properties and substitution patterns. Notably, quinazolinones with methoxyl were all compatible to give products 3oa-3pa with good yield. Moreover, product with a phenyl substituted product 3qa can only be obtained in 52% within 48 h. Table . Quinazolinone scope for N-aminoalkylation of quinazolinones.