)=N \O, 3, 3), which was over-represented in the FivePlus set by a factor of 24.28, but the number of molecules with this particular combination is so low it makes it hard to know how much weight to give this observation. We determined by visual inspection that the imidoyl halide and oxime functional groups were in close proximity in these molecules, such that they may form a conjugated system. The force fields inconsistently predicted planar groups within this larger system. Two other descriptor pairs were over-represented in the FivePlus set by a factor greater than 19: