To determine feasibility, reactions were initially tested and developed using standard bench chemistry (Suppl info. 2,3,5,6) with a specific focus on solvent selection and solubility. Dimethylacetamide (DMA) proved to be a general solvent and was used in all the chemistry developed and executed on the OpenTrons OT-1. Thereafter, the reaction conditions were translated to the OpenTrons OT-1 as a liquid transfer-only process (Suppl info. 7). To test the validity of using the OpenTrons OT-1 for chemistry, three iterations (Iters 1.0, 1.1 and 2.0) of single and two-step chemistry for the formation of ureas and amides were explored (Fig. ). 180 targets were attempted via the execution of 296 reactions, with a combined success rate of 83%, as defined by the identification of the expected molecular ion peak, by LCMS in the CRM (Fig. ). Iter 1.1, exploring a "deletion" strategy, by effectively replacing the piperazine central core by a morpholine, and Iter 2.0, exploring an amide linkage vs the urea in Iter 1.0, yielded no structural hits. This demonstrates that we can rapidly scope structural features and "fast fail, fail cheap", quickly redefining our synthetic strategy. Even negative results, obtained quickly, can have insightful impact in these labour-intensive processes (Fig. ).