In the presented work, we made significant improvements to the performance of the QUICK/AMBER QM/MM implementation and enabled support for AMD GPUs. The benchmark results show that realized speedups on NVIDIA GPUs are multi-fold with respect to the previous release version. Performance on the MI100 GPU is similar to that of the V100 for moderate sized QM regions. Using our latest implementation, AMBER users will be able to carry out more efficient QM/MM simulations on a wider range of hardware choices. As for the future directions of this project, room for performance optimization should be explored further.