During synthesis two drug (fluorescein and daunorubicin) were loaded into the PPy nanoparticles. Not only were those two drugs exposed to organic solvent their hydrophobicity was key to encapsulation . However, such systems would typically be unsuitable for peptides as exposure to organic solvents often results in denaturation and loss in bioactivity . The formation of peptide-ion pairs and concomitant improvement of peptide stability in solvents such as ethanol (see Supporting Information, Section S4) as well as increased hydrophobicity is likely to expand the possibility for other peptides and possibly some proteins.