At the outset of designing a new flow solu on to electrochemistry we considered that in order to provide a solu on that was relevant to the pharmaceu cal industry, the reactor would need to balance demands on throughput, modularity, and the space available in common manufacturing environments. Developing the op mal condi ons for an electrochemical reac on in flow would, therefore, require achieving a balance between maximizing selec vity for the desired product and maintaining high reac on rates to achieve high throughput in a small footprint reactor. In batch, the two primary methods for conduc ng electrochemical reac ons are using either constant current or constant poten al electrolysis. Although widely reported, constant current reac ons exhibit variable cell poten al during electrolysis, leading to difficul es in controlling the selec vity of the reac on, par cularly at higher conversions of substrate (Figure ). Alterna vely, constant poten al reac ons can be highly selec ve, but tend to provide slower overall rate of reac on, because the current is variable. Objec vely, highly selec ve electrochemical reac ons hold promising applica ons to complex pharmaceu cals; hence, we focused our efforts on developing a constant poten al, single-pass flow reactor using our rod-based reactor design. Consequently, we set out to determine the parameters that could be most effec ve in tuning rate and selec vity using constant cell poten al.