The exploration for tetramethylethene and ozone, CRN-T, generated 388 compounds and 441 reactions (Table ). The serial computing time for the CRN-T exploration was 11600 days, and the total computing time, using an average of 250 cores, was reduced to approximately 47 days. We compared some structures generated for CRN-T with the initial steps leading to the tetramethylethene ozonide intermediate in analogy to the CRN-E evaluation. CRN-T contains the key compounds depicted in Figure , thus confirming that the product hypothesis is also met for this exploration. The CRN-T exploration also found water as compound. Figure shows an analogous representation of Figure for CRN-T, where the key ozonide compounds and its transition state were successfully identified. However, one experimentally reported side-product was not found, which corresponds to the product of the partial oxidation of tetramethylethene: 2,3-dimethylbutane-2,3-diol. In fact, the reaction exploration did not find any diol compound.