That is, nodes i and j are connected by a short edge (w i j → 0) if the fluctuations ∆r(t) = r(t) -⟨r(t)⟩ of their C α atoms along a molecular dynamics trajectory are highly correlated (C i j → +1) or anticorrelated (C i j → -1). Conversely, a long distance is assigned to edges (w i j → ∞) between nodes if their fluctuations are uncorrelated. This graph is further simplified by removing edges between residues without any atom pair distance below the contact map cutoff p cutoff = 4.5 Å as described in Ref. 36.