The 157NN top-child could be a desirable exceptional conformer targeting ordered CSP domains independently of the presence of both SP and NANP-repeat shields. Therefore, efforts to tailor 157NN-derivatives to CSPmin were explored to possible increase affinities. Those alternatives included, increasing the number of 24C fitted-children (n=4028) , limiting to 3-rings the DWBEL criteria, expanding molecular weight DWBEL preferences from < 600 to < 700 g/ml, and/or using alternative artificially-derived parents. However, despite those efforts, only a few new conformers could be derived which predicted similar affinities (~ 76 nM) and similar amino acid contacts (Table ). However, additional DWBEL iterations targeting CSPmin to sequentially tailor 157NN and 384NN-derivatives, predicted new top-children with ~ 27 nM affinities (Supplementary Materials / 1770CSPmin.dwar and 18CSPmin.pse). The new top-children derivatives increased to 7 the rings per conformer (Figure , 17508-ID3), and induced additional amino acid contacts including new Hydrogen bonds (Table ). Perhaps, additional iterative "tailoring" to CSPmin cavities could discover compounds with higher affinities, but that was beyond this actual scope.