In the following sections, we will explore some of the recent advances in understanding of the mechanisms of MOF adsorption-induced flexibility, along four new directions of research: (i) advanced computational methods to understand the impact of guest adsorption on MOF flexibility, (ii) the control of flexibility and the tuning of the materials behavior, (iii) the impact of defects and crystal size on flexibility, and (iv) the use of framework flexibility to realize novel applications.