AMOEBA is a polarizable force field that uses a multipole expansion up to quadrupoles on specific centers (atoms) to represent the permanent electrostatic component. The polarization is taken into account using the induced atomic dipoles approach 20 coupled with a Tholé damping function to avoid the so-called "polarization catastrophe" at short distances. For van der Waals interactions, the buffered Halgren pairwise potential is employed following the AMOEBA FF functional form. The mathematical form of this potential is as follows: