Another limitation is the choice for the specific datasets that were aggregated into Papyrus in addition to ChEMBL. Firstly we have implemented ExCAPE-DB, like we did in previous work. The single article datasets are a reflection of some of the interests of our group, and we value the high quality data present. There are enough arguments to include a certain dataset that we did not mention here, which would improve the quality of the dataset even more. We do provide the full dataset and all the descriptors that are used. So if anyone wants to add a certain dataset the tools are available to do so. Our goal was to create a benchmark set to set a reliable standard to perform bioactivity modeling on, and we think that Papyrus meets that goal.