As it is not clear, what value for γ cleave should be used, we investigated its impact at the example of the "Intrinsic Bond Strength Index" (IBSI) descriptor. We determined the inflection point of -T ∆S for a set of γ cleave values, testing different -T ∆S fits. As a consequence, different ∆G f it curves and barriers ∆G ‡ result. A set of free energy curves obtained with the IBSI descriptor is shown in Figure , the raw data using IBSI and γ cleave = 0.01 is depicted in Figure . Clearly, the definition of the value of γ cleave has a big impact on the resulting energy barrier.