Skin tissue fabrication has posed unique challenges in tissue engineering. Engineered tissue cells can be used to restore or replace damaged tissues and organs. Cell placement in the tissue construct is limited and accounts for the spatial relations between the extracellular matrix and cells. In general, a hydrogel scaffold is used, and the cells are integrated with a thermal inkjet printer to deposit the bioink. To mimic the complexity of the skin tissue structure, a laser assisted bioprinting (LaBP) technique is used for the positioning of different cell types in an exact 3D spatial pattern. Tissue engineered skin substitutes have widespread applications, from aiding patients in tissue regeneration to replacing animals in research, whether for pharmaceutical or cosmetic needs. Utilizing methods with a cellularized skin equivalent can revolutionize the field.