In Figure , the mean SASA values of the atomistic fragments are compared to their coarse-grained counterparts, with the corresponding standard deviations. The coefficient of determination R 2 is close to 1, which indicates that there is a good correlation between the values of the atomistic and coarse-grained fragments, similar to the R g case (R 2 = 0.850). A slight systematic overestimation of the SASA of the coarse-grained fragments is visible only among the higher values. The results indicate that, overall, there is a good reproduction of the fragment's molecular shape. This implies that although Swarm-CG does not use the SASA as a target for the parametrization, matching the distributions of bonded interactions can enable a good reproduction of this quantity. In contrast to these results, the parametrization of carbohydrates for the Martini 3 force field initially led to a systematic underestimation of the SASA . This was resolved by scaling the bond distances by 15 %. In Figure in the supporting information, the SASA values of the coarsegrained fragments are compared with values from the mapped atomistic fragments and the atomistic fragments, using van der Waals radii from the GROMOS force field. Again, very good correlations are visible for both cases.