Regarding the cannabinoids, Figure shows the concentrations found in positive urine samples for cannabinoids and metabolites, concentration ranging from 4.905-40.52 ng/ml for THC. The isomeric CBD was baseline separated from THC in the LC dimension and was found on the range of 1.571-828.6 ng/ml. The metabolites that confirm the consumption of cannabis were found in the urine samples in the range of 1.203-93.36 ng/ml for THC-OH, 21.71-1160 ng/ml for THC-COOH and 43.13-3490 ng/ml for THC-COOH-GLU (when measured by LC-vDMS-SIM/MS). Results of the reanalysis of the samples by the reference LC-MRM/MS method are presented in Figure and S6. No significant bias is observed between the LC-vDMS-SIM/MS and LC-MRM/MS methods.