In order to characterize the chemical diversity of Nat-UV DB and to explore its chemical space coverage, approved drugs and the Latin American natural products compound database (LaNAPDB) were used to compare their chemical structures and properties. The structure files used in this work were taken from open repositories of previously published analyses of natural products databases . The structures of the reference compounds were curated using the same procedure described to prepare Nat-UV DB. Table summarizes Nat-UV DB and the reference databases and the number of compounds. Of note, the reference collections included data sets of natural products, including two from Mexico.