The various applications of DNA-based nanomaterials have demonstrated significant potential, thanks to the many highlighted benefits. In this discussion, after we address the production considerations associated with utilizing the DNA origami method as the most noteworthy platform, we explore the potential of DNA nanotechnology as a viable strategy for achieving treatment with oligonucleotide drug delivery. By reviewing DNA nanotechnology in dynamic nanodevices and looking through DNA computation, we envision the opportunities and possibilities that could be realized through the application of DNA-based technologies in the delivery of nucleic acid drugs in precision medicine of cancer therapy.