Tecovirimat-docking to F13L0, predicted similar amino acids at 4 Å distance than those reported before (Table , yellow left columns). The wide blind-docking grid, allowed the exploration of any alternative docking cavities, while predicted the highest affinities for Tecovirimat and IMCBH 55 (Table ). The near canonical phospholipase-like motif ( 312 NxKxxxxD) , their probable 334 H 338 H requirements for phospholipase activity, and the E353K mutation present in all isolates of the MPXV 2022 outbreak, mapped behind the docked Tecovirimat (Figure , Blue background ellipse, and Table , yellow columns).