Each MITE entry represents a single discrete enzyme, encoded by a single discrete gene. Where applicable, multiple protein isoforms of a gene are represented as multiple MITE entries. While MITE is primarily focused on enzymes from NP BGCs, enzymes encoded by unclustered genes that perform tailoring/maturation reactions on immature NPs are also accepted. introduction of an additional sugar moiety). Therefore, a reaction SMARTS serves two purposes: first, recognition of the substrate (sub)structure, and second, introduction of modifications.