Thermo-responsive liposomes are currently deployed in oncology with ThermoDox being the most prominent system. It has been investigated in several clinical trials in combination with radiofrequency ablation . . The possibility to trigger drug release in an "on/off" manner may be particularly promising as an approach in the development of pulsatile release systems. We conceptualised that teriparatide loaded thermo-responsive liposomes would release the peptide upon a brief and localised temperature increase. Hyperthermia may be achieved through incorporation of near infrared (NIR) responsive materials (e.g. gold nanoparticles or polydopamine). These materials absorb energy from light and convert it into heat. NIR in particular, has high tissue penetration due to low absorption of NIR from biological materials. By adapting the intensity and duration of irradiation, the dose released is controlled .