and m C38 was defined to be -120 . This highlights the power of GaMD being able to sample more of the configuration space than WE. GaMD can sample orthogonal modes to the chosen CVs χ 1 -C14 and χ 1 -C38 since it is a CV free enhanced sampling method. In contrast, WE mainly samples along the chosen CVs and can encounter difficulties in sampling regions when there are orthogonal modes present to the chosen CVs. Although rate constants between these metastable states were not measured, it is expected that GaMD-WE will sample them significantly faster than conventional WE.