Comparing the historical connectivity between bioinformatics and cheminformatics points towards the root of the problems we currently face. Over more than three decades the links between sequence data and the literature have become a blazing success, first for molecular biology followed by genomics. This was driven mainly by the combination of journal mandates for author inclusion of sequence accession numbers and somewhat later, pointers to genomic and expression data sets. This has needed herculean technical integration efforts not only from the , would be a chemistry ratio of roughly 2:7 million (i.e. a public shortfall in the order of ~5 million although the major part of the later comes from patents)