The electrocatalysis community has had an awakening regarding the fundamental science challenges that underlie operational durability, which is particularly important in nonprecious-metal acid OER catalysis. The measurement of equilibrated dissolved metals concentration may serve as an important indicator of long-term durability, and while there have been initial demonstrations of time-resolved measurements via online detection, such measurements remain prohibitively expensive for high throughput exploration of high dimensional composition spaces. The present work focuses on decreasing the concentration of elements most prone to corrosion by exploring quaternary and quinary oxides in which Mn is mixed with various combinations of Sb, Sn, and Ti. XRD analysis confirms that a site-substituted rutile phase can be synthesized over a broad range of compositions in the Mn-Sb-Sn-Ti-O composition space. The results demonstrate a catalyst motif wherein activity is realized at low concentration of the presumed catalytic element (Mn) via integration with multiple elements that resist corrosion (Sn, Ti, Sb).