To investigate the effect of similarity-based Curriculum Objectives on solution space diversity, cross-Tanimoto similarities between each unique compound pair in the pooled datasets were calculated to quantify how different the collected compounds are to each other (see Methods). Relative to the baseline RL experiments, collected compounds in the CL experiments exhibit greater intra-set similarity, interpreted as the agent sampling compounds from 'closer' areas in chemical space (Fig. ). Moreover, the "High" scenarios have a greater density of high cross-Tanimoto similarities than the "Low" scenarios.