Furan-maleimide cycloaddition reaction has been successfully employed earlier to develop cellladen hydrogels, hydrogels emulating the ECM, tough hydrogels, stimulus dependent selfhealing hydrogels, and for sustained delivery of drugs or therapeutic factors. Furthermore, furan maleimide cycloaddition reaction has been recently used for preparing gelatin-based hydrogels, drug delivery, and for developing nanoparticle carrying hydrogels. However, temperature as high temperature as 65 ºC was needed to perform the crosslinking leading to hydrogel formation. Furthermore, these hydrogels were non-injectable and lacked self-healing properties at ambient temperature, and in some cases required incubation at 37 °C for 5 hours to achieve self-healing following a single incision. To date no example of injectable collagen hydrogel exists which could undergo autonomous self-healing after injection. Although, we have developed several bio-orthogonally crosslinked injectable, shear-thinning collagen hydrogels with shape-retaining property, autonomous self-healing could not be achieved. Here we report an injectable collagen hydrogel crosslinked through the cycloaddition reaction between furan and maleimide which undergoes complete autonomous self-healing at ambient temperature after injection. The developed hydrogel is shear-thinning and can be injected in gel state up to after 2 days of preparation. Furthermore, this hydrogel can hold its shape after prolonged storage in buffer and yet can be degraded within hours in vitro by collagenase and can be resorbed completely within two months in vivo. Last but not the least, cardiac stem cells and endothelial cells can be encapsulated in these hydrogels without any noticeable toxicity.