FMOPhore performs QM-FMO to calculate binding interaction energies described by the inter-fragment interaction energy (IFIE) and its pair energy interaction decomposition analysis (PIEDA). This allows the estimation of protein-ligand interactions with quantum (electronic) effects using a low level of computational resources. By means of PIEDA, the FMO interaction energy; (ΔE FMO ), is calculated as the sum of five energy terms of polar and hydrophobic interactions, given by: electrostatic (ΔE We apply FMOPhore algorithm in two different scenarios: