Coupling between chemical transport and reaction kinetics is emphasized in the transformation of therapeutic agents applied to the integumentary system. The pharmacokinetics and pharmacodynamics of topical treatments are contingent upon the diffusion rates through skin layers and the subsequent biochemical interactions they undergo . This nexus plays a critical role in determining treatment efficacy and patient outcomes in conditions like atopic dermatitis, where prompt and effective delivery of anti-inflammatory agents can drastically influence healing. The rate of ROS generation and detoxification in photoaged skin correlates with the diffusion rates of antioxidants and their interaction with cellular targets . Such interactions dictate the extent of oxidative damage and subsequent cellular responses, influencing disease progression and treatment outcomes. In wound healing, the transport of growth factors and their subsequent biochemical interactions are tightly regulated. Any dysregulation can lead to chronic wounds or excessive scar formation . Additionally, in melanoma, the diffusion of melanin precursors and their enzymatic conversion is critical in tumor growth and metastasis .