Here we present a family of 10 novel zirconium ellagate frameworks (SU-103 -SU-112) made from identical synthesis conditions with the exception that a different amine or ammonium reagent was used as the OSDA for each MOF, i.e. the same ratio of reagents, heating time and temperature have been applied. The convenience of being able to repeatedly apply similar and synthesis conditions and to determine the structures of these submicrometer-sized crystals quickly by 3D ED allowed for accelerated discovery of novel materials. The discovery of the guest-directed MOFs and the details of the interactions between framework and guest were made possible using electron crystallography and the systematic study of their location and coordination provide insight to the structure-directing role of the amines.