Using this information to create kinase-focused chemical matter could therefore be extremely useful. The remaining 21% of the fragments were bound to more than one kinase. More than three quarter of this fragment set even co-crystallized with kinases from more than one group. This result supports the conclusion that fragments can be promiscuous, i.e. identical fragments can interact with multiple different kinase targets. Instead, the combination of different fragments could be the key for kinase selectivity.