The ADV blind-docking top-children conformers (n=100) derived from 24L by DWBEL, predicted 100 % targeting to their initial 24C. In contrast, 99 or 65 % from the 28L-or 23L-derived DWBEL top-children conformers, respectively, also targeted 24C, instead of targeting their corresponding 28C or 23C (not shown). These results suggest that 24C is the dominant cavity when the full-length CSP is targeted by blind-docking. Such displacement of the targeted cavities could be due to random conformer generation by both DWBEL and ADV algorithms, before selection of only the best-fitted cavity/conformer per children in each case(local cavity by DWBEL and many cavities by ADV blind-docking. In many of those cases, the DWBEL-to-ADV displaced cavities were targeted with lower affinities (not shown).