HTE is also growing in popularity because the means to perform it have improved. This includes robust ways of dosing solids into reaction vials , wider adoption of glove boxes for more reproducible reaction execution, LCMS for reaction analysis and an ever increasing universe of commercially available (pre-)catalysts, reagents and building-blocks. However, powerful yet user friendly open-source tools to integrate all the data and devices into a work ow are lacking. Hence, we decided to build our own system orchestration and data analysis software to support our approach to HTE. We call it HTE OS and make it available for free as part of the Supporting Information. Lab Work ow Integration through HTE OS Figure : The HTE OS work ow streamlines lab tasks in brown boxes using a highly automated data work ow in blue boxes, guiding the operator from request initiation to result reporting.