An increase in the values of certain descriptors related to molecular branching (e.g., WTPT-5 and WPATH) and the number of hydrogen bond donors (nHBDon) leads to decrease in predicted solubility, as they determine the type and strength of intermolecular interactions. Conversely, an increase in fluid density and state parameters, as expected, enhances solubility. Qualitative analysis indicates that the model successfully captures the fundamental structure-property relationships, which align well with established physical and chemical principles of solubility modeling, thereby validating the its correct operation.