While the typical function of biological condensates results in regulation of cellular processes, aberrant function may lead to development of various diseases or disorders such as neurodegenerative or genetic diseases , including repeat expansion disorders. However, one disease that is less well-known to be LLPS-mediated is cancer. In particular, genetic mutations that impact DNA damage response and repair, chromatin organization, genomic stability, or transcription, influence the transformation of cells from benignancy to malignancy. Specifically, malignant cells result in aberrant cellular activity such as uncontrollable proliferation, signal pathway disruption, metastasis, angiogenesis, and cancer cell evasion from growth suppressors. A number of these oncogenic activities are, one way or another, driven by the dysregulation of LLPS and are critical factors in the development of cancer cells or tumors, i.e, tumorigenesis. As a result, understanding the mechanisms of LLPS that result in these tumorigenic processes will help to demystify the complex role of LLPS in tumorigenesis, which could lead to LLPStargeted cancer intervention treatments in the future.