Py1-4, Py6-7, Py9-11, Py14-15). P2CAs bearing electron-withdrawing groups such as -F, -CN or a carboxylic acid were less efficient substrates (Py8, Py12, Py13). We were also pleased to see that quinoline carboxaldehydes are also excellent substrates (Py17, Py18, Py20). Somewhat to our surprise, macrocyclization proceeded smoothly even with several 2-ketopyridines (Py21-24), further extending the number of substituents that can be introduced into the macrocycle using this strategy. We conclude that the scope of the reaction in the pyridine moiety is broad, though electron-withdrawing substituents result in somewhat lower yields.