We tested the effectiveness of the U parameter calibrated from the SBU by using it to perform PBE+U calculations of the full periodic MOF structure. The MAD of PBE+U calculations, when compared to HSE06 results on the full periodic MOF, is found to be 0.06 eV for both the SBU-specific and metal-specific U parameters, exhibiting a substantial improvement over the MAD of 0.13 eV when using standard PBE (Figure and Supporting Information Figure ). Consequently, our findings confirm the hypothesis that a U value calibrated using a truncated SBU model will successfully correct properties of the periodic MOF structure. PBE+U calculations using an SBU-calibrated U value match adsorption energies from periodic hybrid calculations better than hybrid calculations on SBU models do (MAD = 0.06 eV vs 0.07 eV, Supporting Information Figure ). Therefore, the calibrated U parameter enables the GGA-level calculation on the periodic MOF to achieve similar accuracy to the hybrid-GGA-level calculation on the SBU, while also benefitting from the incorporation of the environment effects of incorporating periodicity.