For the final multicomponent graph, the graph automorphism search is applied to each component separately to examine subsystem symmetries. As the number of components increases, the total number of symmetries grows exponentially and equals the product of the number of symmetries of each non-connected part. On the other hand, the total number of orbits shows a linear growth and is equal to the sum of the number of atoms with distinct neighborhood chemical compositions in each component. For instance, the system consisting of a 7 × 7 graphene sheet and 1,8-naphthyridine molecule has a total of 1176 permutational symmetries. Specifically, 588 of these symmetries come from graphene, while two come from the 1,8-naphthyridine molecule. However, this system has ten distinct neighborhood chemical compositions, consisting of one orbit from graphene and nine orbits from the 1,8-naphthyridine molecule.