Fig. resembles Fig. of M. P. Andersson's publication. The solubilities (mole fraction in the aqueous phase) at temperatures between 250 and 400 K are shown for eight common organic compounds. Experimental solubilities were taken from literature. The Andersson model of water clusters is able to find a solubility minimum for all of these compounds. BIOVIA COSMOtherm FINE 2023 is able to find the solubility minima for hexane, cyclohexane, carbon tetrachloride, 1-hexanol, 4-methyl-2-pentanone, benzaldehyde and 2,3dimethylpyridine. Noteworthy, it does so without using explicitly optimized water clusters. Instead a proprietary correction to hydrogen bond terms is used to account for the hydrophobic effect. Only monomeric water is included in the In contrast to the Andersson model of water clusters, BIOVIA COSMOtherm FINE 2023 is not able to find a solubility minimum for benzene. Also, the sudden miscibility of 2,3-dimethylpyridine and water at low temperatures is not correctly reproduced. A systematic search for the critical temperature finds the closure of the miscibility gap at about 207 K (significantly below the experimental value of 289 K). Fig. resembles Fig. of M. P. Anderssons's publication. The temperature of solubility minima is compared between COSMO-RS calculations and experiment. In addition to the compounds shown in Fig. , reference also includes the data for anisole, for which BIOVIA COSMOtherm FINE 2023 did not find a solubility minimum. Taking only into account compounds for which both methods find a minimum, the accuracy of BIOVIA COSMOtherm FINE 2023 (RMSD 10.9 K) is slightly better than the accuracy of the Andersson model of water clusters (RMSD 14.2 K).