Comparing the conformer index at the AMC-xTB level of theory with the final ωB97X-D/6-31++G(d,p) level of theory with the quasi-harmonic approximation (cutoff of 100 cm -1 ) the Gibbs free energy minimum at the DFT level is also the electronic energy minimum at the AMC-xTB level of theory for 66 of the clusters (See Figure ). If 10 conformers are included from the AMC-xTB level of theory, the free energy minimum energy is captured for 155 out of the 288 clusters with improvements found for 209 (Se Figure ). Furthermore, the maximum error is 2 kcal/mol with a mean of 0.12 kcal/mol when reducing from 50 to 10 conformers. This highlights the need for including dynamics-based sampling procedures for atmospheric clusters even though the system might seem fairly rigid. It can also be envisioned that the improvement workflow will be quite important when studying much larger (SA) 1-20 (base) 1-20 clusters as recently done by Engsvang et al. and Wu et al. For large clusters, the global minimum is tricky to locate, and adding dynamics-based configurational sampling might aid in the process.