To maximise the chance of discovering one or more scenarios that may lead to life's origins, we propose that the community should focus especially on those scenarios that show the greatest empirical support. These scenarios in particular should be the most intensely tested and challenged, 14 in order to identify and explicate experimentally and observationally grounded candidate solutions to the problem of life's origins. This approach often begins by identifying what is inevitable in a planetary environment, or, to borrow the phrase of Benner, what "can't not happen". It can also start by considering what is impossible in a planetary environment, what "can't happen." However, between what is necessary and what is impossible, there exists what is possible yet not guaranteed. Often discussions of possibility can become conflated with plausibility. Prebiotic plausibility is typically applied to the chemical and physical boundary conditions of a proposed environment for prebiotic chemistry. Beyond boundary conditions, a complete account of prebiotic plausibility must consider the likelihood of reactions occurring in sequence under environmental conditions. We propose that these probabilities can be summarised as the translation of a chemical sequence from the laboratory to a natural environment. We further propose that these probabilities can be quantitatively estimated using kinetics. This is the logic behind the work our lab is focused on. We begin by taking known prebiotic scenarios that have proven successful in the lab and identifying natural environments in which these scenarios could occur. We then test these reactions under prebiotically plausible conditions either with no interference from a chemist or with the interference of the chemist minimised and carefully accounted for. We term this approach do-nothing prebiotic chemistry.