The DFT refinement step localizes the 18 target reactions remaining at this point as well as 34 new reactions with barriers below 30 kcal/mol. Twenty-five of the new reactions are located from the reactions found using our default parameter set while the remaining nine reactions are found by penalising products found by the first meta-MD runs. The 34 new reactions are spread across 12 of the 20 reactants. Figure shows the lowest-barrier reaction for each of these 12 reactants and the remaining 22 new low-barrier reactions can be found in Figure . The new reactions represent a range of reaction energies between -47 and 20 kcal/mol and barriers ranging from 0.5 to 29 kcal/mol. We find both reactions where the two reactant molecules react with each other and unimolecular reactions where one of the reactant molecules goes through an isomerization reaction.