The LY3537982 simulation data suggests that the key interactions occur with Gly10, Glu62, Glu63, Asp69 and Tyr96 (Figure ). The Gly10 residue interactions are water mediated H-bonds to the ether of LY3537982. The carbonyl oxygen of the heterocyclic ring system is capable to mediate the water-bridged interactions to polar residues in the solvent interface, including Glu62, Asp92 and Tyr96. The Tyr96 residue also participates to hydrophobic interactions with a relatively