Several scoring functions were used in this work to guide optimization and benchmark RL strategies. These are summarized in Table and are described in more detail in the subsequent sections. All scoring functions were implemented using the MolScore platform (manuscript in preparation). ). The four targets and corresponding x-ray crystal structures used in the docking tasks were D2 (DRD2, PDB: 6CM4 ), µ (OPRM1, PDB: 4DKL ), AT1 (AGTR1, PDB: 4YAY ) and OX1 (OX1R, PDB: 6TO7 ) receptors.