A triple quadrupole platform was used for the study and validation of the formulas derived in the theory section. The separation was carried out with a G7100 capillary electrophoresis (CE) system from Agilent Technologies (Waldbronn, Germany). Separations were performed using a fused silica capillary purchased from BGB technologies (Boeckten, Switzerland) with a total length of 70 cm and an internal diameter of 50 µm. Prior to its first use, the capillary was conditioned with MeOH, H 2 O, NaOH 1M, H 2 O, HCl 1M, H 2 O, HCl 0.1M, H 2 O, and BGE at 5 bar during 1 minute each. Injections were performed hydrodynamically by application of 50 mbar during 12 s, using ∼1% of the capillary total length, circa 14 nL. Injected volumes were calculated with Zeecalc v1.0b (). Separation was performed by application of + 30 kV. Before each analysis, the capillary was washed with MeOH and BGE at 5 bar during 1 minute. To avoid temperature inhomogeneities between the capillary parts inside and outside the CE instrument, the CE thermostat was set at room temperature (∼23 • C).