The polymers were synthesized following a general procedure based on previous reports. Exemplarily, the preparation of methyl-PMeOx 35 -b-PPheOzi 15 -b-PMeOx 35 -N-Boc-piperazine (A-PPheOzi-A, B1) was performed as follows. Under dry and inert conditions 131 mg (0.80 mmol, 1 eq.) MeOTf and 2.39 g (28.1 mmol, 35 eq.) of MeOx were added to 23 mL dry PhCN and stirred for 4 hours at 110 °C. Full monomer conversion was verified by 1 H-NMRspectroscopy before adding the monomer for the second block. The mixture was cooled to room temperature, and 2.07 g (12.8 mmol, 16 eq.) of PheOzi was added. After stirring over night at 120 °C, 2.39 g (28.1 mmol, 35 eq.) of MeOx was added. After completion of the third block termination was carried out using 298 mg (1.6 mmol, 2 eq.) N-Boc-piperazine and stirring for several hours at 45 °C (termination with 3-(2-furyl)propionic acid was performed with 2.4 eq. of freshly sublimated carboxylic acid and 3 eq. of dried trimethylamine at 60 °C). After cooling to room temperature, 111 mg (0.80 mmol, 1 eq.) potassium carbonate was added and the mixture was stirred for 5 hours. The solvent was removed at reduced pressure and the flask was placed in a vacuum drying oven at 40 °C and 20 mbar for two days to remove remaining benzonitrile. The residue was dissolved in deionized water, dialyzed overnight using a membrane with a MWCO of 1 kDa and freeze-dried (yield: 6.21 g, 88.7 %).