This is the first study to demonstrate the deep defluorination of liquid undiluted AFFF by piezoelectric BM at ambient temperatures and pressures. The innovation addressed the critical need for non-thermal AFFF treatment. Our fundamental contribution is to identify CLFT as the critical descriptor for the BM treatment of liquid waste. We present a closed-loop research workflow of building the CLFT theory based on experimental data and, in return, using the theory to guide the process improvement.