Di↵erent fingerprint bits encoding di↵erent sp3 -hybridized carbon substructures are found important across all datasets by the Fingerprint model. Furthermore, the descriptor FractionCSP3 is found important by the Descriptor model for all the datasets. The presence of sp3 -hybridized carbon substructures is noted to impact the model output towards the lysosomotropic class, and vice-versa, in all of the cases.