Additionally, most nanomaterials are only affected by perturbations in their direct vicinity. Consequently, the precise orientation of the recognition unit can be important for the performance of a nanosensor which renders larger recognition units difficult to implement in high throughput approaches. This said, most larger screenings are based on evolving "non-rational" corona phases. These corona phases contain polymers that adsorb on the nanomaterial, as well as analytes that binds to this complex interface. Consequently, an evolution of adsorption-based surface modifications and methods combining such adsorption-based approaches with a rational design are highly desirable.