In Figure the mean values of the radius of gyration, R g , from the atomistic fragments are plotted against the mean values from their coarse-grained counterparts. The error bars are the corresponding standard deviations, which should be seen as a measure of the fluctuation of R g over time. Overall, a good correlation between the two quantities is visible, with minor deviations at the lower and higher range of values. In general, it is to be expected that lower values of R g will deviate more from the reference, due to the relatively low number of beads for small molecules, thus reducing the accuracy of R g compared to the reference. The results shown in Figure partially validated the choice of mapping and the decision to conduct the parametrization using Swarm-CG, which resulted in a good reproduction of the overall size of each fragment.