Table summarizes the compound databases analyzed in this work, including the number of compounds before and after standardization, described in section 2.1. One such database is NPDBEjeCol, a compilation of NPs isolated and characterized in Colombia. BIOFACQUIM is a collection of natural products isolated and characterized in Mexico; the Nuclei of Bioassays, Ecophysiology, and Biosynthesis of Natural Products Database (NuBBEDB) is a collection of compounds from Brazil, and PeruNPDB is a database of natural products from Peru. FDA-approved drugs were retrieved from DrugBank.