These results definitely warrant further studies into the structure-activity relationship of these compound class. Initial insights showed that substitution of the chloride ligands on Pt1 generally results in a reduction of antibacterial activity, suggesting that chemical alterations of the COD-fragment may be more favorable. One concern with Pt1 is its potential stability under biological conditions. In a preliminary stability study, incubation of Pt1 in DMSO for seven days at room temperature resulted in no changes of the 1 H NMR spectrum, suggesting that the compound is stable under these conditions (Figure in SI). Future work will be aimed towards more comprehensive examinations of the chemical and biological stability of these and related compounds, as well as investigations into their mode of action.