Producing a correct binding pose when a large cofactor is present is independent of the cofactor itself. This is shown for the flavin-adenine dinucleotide cofactor in Figure where the dominate interaction between the ligand and the cofactor is π-π stacking. The ability to produce a good pose is still present when the type of interaction changes dramatically, as shown for the binuclear metal center formed by zinc and-magnesium in Figure . This interaction is important for developing phosphodiesterase inhibitors , therefore it is encouraging to observe CANDOCK's ability to produce a crystal pose in these cases. From these four case studies, we can conclude that CANDOCK is able to produce a reasonable docking pose in the presence of diverse cofactors.