Note that the experimental condition for the "resonant condition" is specifically referred to the case at the incident angle θ = 0, where the cavity frequency matches a particular vibrational frequency. This is indicated by the schematics in Fig. . The setup illustrated in Fig. , on the other hand, has a finite detuning between light and matter at θ = 0. Even though it also has a resonant condition (zero detuning) at some finite θ, there is no VSC modification of the rate constant observed experimentally for this case. Meanwhile, other experiments show a resonant enhancement of ground state chemical kinetics. For example, as shown in Fig. adapted from Ref. 112, the reaction rate constant is enhanced and peaks at a maximum when the photon frequency is close to a solvent vibrational frequency (which is the C=O stretching frequency of the EtOAc solvent). On the other hand, a recent work 117 has observed much smaller (≈ 1.5 times enhancement) rate enhancement for the same reaction under VSC, conflicting the results in Ref. 112. Interestingly, their results show that modification of the chemical reaction occurs for non-zero detunings. More interestingly, when there are two competing reaction pathways outside the cavity, it has been demonstrated that coupling them to the cavity can achieve mode-selective chemical reactivity. That is, the coupling of molecular vibrations to the cavity can selectively favor one chemical reaction over another, com-pletely reverting the original selectivities compared to the situation outside the cavity. This mode selectivity is shown in Fig. 19d, adapted from Ref. 4, where the yield of product 2 exceeds that of product 1 inside an optical cavity when tuning the cavity frequency to be resonant with a variety of bond frequencies. This is in contrast to the situation outside the cavity (or in the off-resonant scenario with a very large cavity frequency ω c ≈ 5000 cm -1 ), where product 1 is formed more than product 2. In a similar experiment, the siteselective reaction of the aldehyde over the ketone in 4-acetylbenzaldehyde is achieved by automated cavity tuning to maintain optimal VSC of the ketone carbonyl stretch during the reaction. Experimental works have attempted to provide physical insights by computing the modification of thermodynamic parameters. Ref. 33 investigates the desilylation of 1-phenyl-2-trimethylsilylacetylene (PTA), the same reaction studied in Ref. 110 which is shown in Fig. , and extracts thermodynamic parameters assuming that the chemical rate is given by the transition state expression (Eyring theory)