CM-11 is a synthetic chimeric peptide, composed of fragments from Cecropin A (positions 2-8) and Melittin (positions 6-9) , that exhibits broad-spectrum antimicrobial activity . A recent MD study analyzed CM-11's interaction with simplified models of Gram-positive, (inner) Gram-negative, and eukaryotic membranes . This study identified electrostatic interactions as the key driving force behind the binding of CM-11 to the membrane, facilitated by the amphipathic nature of the peptide .