We investigated a total of 20 different descriptors, either being atomic charges, bond orders and atoms-in-molecules (AIM) indicators. Here, we only show 3 of each group, the remaining descriptors can be found in the Supporting Information Figure -S7. All descriptors were normalised (min, max) to [0, 1] and plotted against the intermolecular distance r O••H , as depicted in Figure . Orders; Intrinsic Bond Strength (IBSI), Mayer Bond Order (MBO) and Laplacian Bond Order (LBO). (b) Descriptors gained from the Atoms-in-Molecules method at the critical point between the bridging hydrogen and oxygen; Laplacian Electron Density (LED), Local Information Entropy (LIE) and Electron Localisation Function (ELF). (c) Atomic Charges: Charges from Electrostatic Potentials using a Grid based method 33 (CHELPG), Hirshfeld atomic charge and the Mulliken Atomic Charge. Filled circles -hydrogen partial charges, diamonds -oxygen partial charges. All descriptors have been normalised and hence are dimensionless.