We believe it is important to distinguish quantum advantage demonstrated for solving (i) theoretical computational tasks, and (ii) practical problems. In 2019, Google announced that it achieved quantum supremacy with its Sycamore processor, performing a calculation in seconds that would take a classical supercomputer 10,000 years . Subsequent studies have however introduced better-optimised classical algorithms, correcting Google's overestimation of the computational costs for a classical computer and ultimately disproving the quantum supremacy claims. In another experiment, physicists in China could find solutions to the boson-sampling problem in 200 seconds using the photonic quantum computer, which would take 2.5 billion years to calculate on the TaihuLight supercomputer 4 -a quantum supremacy of around 10 14 . Nonetheless, the circuit Jiuzhang is not programmable and can not solve practical problems. In the rest of this article, we will focus on quantum advantage linked to solving practical problems in biocatalysis.