We expected that proteins with the highest reactivities to electrophilic species would also be the most destabilized, while proteins whose Hps40 affinities are less impacted by propachlor treatment would be enriched in less reactive proteins. We compared the ranked SSMDs for all identified proteins against reactivity profiles reported in Kuljanin et al. , with the expectation that our strongest hits for each chloroacetanilide would reflect proteins that are generally more active nucleophiles.