In CAR T-cell therapy, the CAR means Chimeric Antigen Receptor and is an innovative approach to combating cancer in the field of immunotherapy . The therapy involves extracting T-cells from an individual's blood, modifying them to express the chimeric antigen receptors (CARs) on their surface, and returning the modified cells to the patient . They are designed to sense specific proteins on the surface of cancer cells and attach to them so that the T-cells can destroy the malignant cells . This therapy has successfully treated several blood cancers, such as acute lymphoblastic leukemia (all types) . Nevertheless, serious adverse effects from CAR T-cell therapy are well-known to exist, including neurotoxicity and cytokine release syndrome (CRS) . Overall, this individualized and targeted form of cancer treatment continues to hold great promise with the expansion of CAR T-cell therapy to other cancers like solid tumors .