The KLIFS pocket IFP comparison performs similarly to the KiSSim comparison in the case of Erlotinib, however, worse for the other three ligands. In contrast to the KiSSim approach, pocket similarities can only be detected by the IFP approach if the respective kinases have been co-crystallized with ligands that form similar interaction patterns. Such an IFP-based comparison probably can be more successful for a defined kinase set with high coverage of co-crystallized ligands in contrast to a kinome-wide comparison as performed here.