The Green colored cell contains the lowest binding energy for each row followed by the greenish-yellow, yellow, orange and red color. The lowest binding energy represents the firm binding of ligand and protein molecules. The Comparative analysis establishes the drugs used for the treatment of Hepatitis C represented a more number of greenish cells. This indicates these drugs stay on top throughout the library used in the present study. The Elbasvir, Ledipasvir, Paritaprevir, Velpatasvir from Anti-HCV followed by Anti-HIV drugs Saquinavir, Ritonavir, Dolutegravir, Maraviroc, Tipranavir, Etravirine and Rilpivirine having good binding energy one or more targets. Only one drug, Antrafenine used for anti-inflammatory and Ergotamine used for anti-migraine activity shown significant activity against the different targets. However, the drugs used worldwide for clinical purposes except for Danoprevir and Lopinavir have shown poor binding with receptor molecules used in the study. The drugs from the list removed having overlapping target applicability. The removal identified 6 unique drugs acting on the multiple targets. The combination of these drugs overcomes the lower affinity of the drug molecules to the specific receptors targeting all the proteins available in the present study. Ergotamine shown good binding against 18 receptors, followed by Lepidasvir, Elbasivir and Pariptapevir respectively against 16, 12 and 9 receptors. While velpatasvir and anterafenine showed binding against 5 which might be very useful in a multi-drug combinatorial approach. The results graded on five color green for lowest binding energy followed by greenish-yellow, yellow, orange and red for the highest binding energy for each receptor.