We next conducted a multi-dimensional electrochemistry optimization study to detect a range of metabolites that could result from caffeine (Figure and supporting information). Figure illustrates how the electrosynthesis reaction aligns with Coulomb's Law equation (Q = It); when the current/electricity flow rate used (I) increases, results in more charge being transferred over time. Consequently, the total charge (Q) passed through the system increases as the current increases. Moreover, the voltage increased as the current used increased in order to maintain the constant current flow during the reaction. This occurs due to the resistance of the circuit changes (increased) according to Ohm's Law (V = IR), where V is electric voltage (V), I is electric current (in amperes, A), and R is electric resistance (in Ohms, Ω).