• Hormonal replacement exhibits strong correlation with osteoporosis Estrogen deficiency is known as the major factor in the pathogenesis of postmenopausal osteoporosis. Hormone replacement therapy -either estrogen alone or a combination of estrogen and progestin -has been approved for the prophylactics and therapy of osteoporosis in women and has been reported to rapidly normalize turnover, preserves bone mineral density at all skeletal sites. 548, 549