and polarizable force fields (AMOEBA) , different charging schemes (AM1BCC , RESP ), several explicit water models (TIP3P , TIP4P-Ew , OPC ) and even implicit solvent . Outside of simulation-based free energy methods, quantum mechanical (QM) and QM/MM (molecular mechanics) approaches were also used , and one group employed machine learning . In addition, several groups submitted multiple predictions (particularly for the GDCCs) and the ensuing results are important to provide insight and give merit to the methods used here. Participants' submissions with specific details on their methodologies are available in the relevant host-guest system directory in the SAMPL7 GitHub repo (https: