We selected two structures from the L99A and L99A/M102Q data sets of T4-lysozyme complexes: 181L and 1LI2, where the ligands are benzene and phenol, respectively. Both complexes were also considered in our recent study of fragmentation protocols for protein-ligand interactions. Each involves two Cl -ions that were combined into a single monomer along with any residues within 2.5 Å of the ion. We also selected two complexes (1O48 and 1BOZ) from the large-inhibitor data set, as examples where the ligands are much larger.