The fitness criteria preferences and their weight values for DW Build Evolutionary Library (DW-BEL) for evolutionary docking (co-evolution criteria), were: minimal DW docking-scores (weight 4), molecular weights <= 600 g/mol (2), cLog <=4 (1) and Toxicity risk <=1 (4). The DW Docking-scores used the mmff94s+ force-field algorithm and specially saved as *sdf files with selected options to best preserve the 2D geometry of the docked children molecules (Table ). The number of runs were limited when reaching 100 Gb of computer memory.