According to the generated PLIFs, the median number of protein-ligand interactions observed among the 2501 measured protein-ligand complexes was 11, with substantial variation across the ligands and targets (Figure ). In comparison, the median number of protein-ligand interactions identified among the docked poses of the active compounds of DUDE-Z was slightly lower (7 for DiffDock-L and 8 for Vina; Figure ). This is plausible because detecting some of the protein-ligand interactions requires considering the conformational changes induced upon ligand binding to the target protein.