This procedure is modified from an earlier reported procedure. In the same manner described for 2 and 6, 2carbomethox-3-nitro benzoic acid (6) (4.5 g, 20.0 mmol) and thionyl chloride The reaction mixture was stirred at room temperature for 24 h. The THF was removed using a rotary evaporator and the residue was quenched by the addition of water (100 mL). The aqueous solution was extracted with ethyl acetate (100 mL), and the organic layer was washed with water (100 mL), saturated sodium bicarbonate solution (100 mL), water (100 mL), and brine (100 mL), and then dried over anhydrous MgSO4. After filtration and concentration of the filtrate, the residue was purified by column chromatography (20:80 EtOAc:hex) to give 13 as residual oil (0.67 g, 59%). Triethylamine (1.67 mL, 1.21 g, 12.0 mmol) was added and the solution was stirred for 15 minutes. 1,3-dithiolane-2-carbonyl chloride (1.22 g, 7.2 mmol) was dissolved in dichloromethane (5 mL) and the solution was added dropwise over a period of 15 minutes. The reaction mixture was stirred in the ice bath for 1h and stirred at room temperature overnight, and reaction mixture was quenched with aqueous solution of HCl and extracted with dichloromethane (50 mL X 2), and the organic layer was washed with water (100 mL), saturated sodium bicarbonate solution (100 mL), water (100 mL), brine (100 mL), dried over anhydrous MgSO4 and filtered. All volatiles were removed and the residue was purified using column chromatography (20: Triethylamine (365 mg, 3.6 mmol) was added, and the solution was stirred for 15 minutes. -benzyloximino acid chloride (650 mg, 3.2 mmol) was dissolved in dichloromethane (5 mL)