Additional performance metrics, such as the duration of the API call, were evaluated and provided in the supplemental information to assess the LLM-based modification scheme's efficiency. The median response time was 10.4 s (to generate 10 molecules), with a mean of 11.5 s and standard deviation of 4.0 s, indicating a long tail. The use of these evaluation metrics is consistent with previous research that has employed similar measures to assess molecule generation tasks.