Through our past work, we have developed techniques that could add unique insights to previous findings on the effect of curvature on ligand exchange reactions. A modified Ising model can be used to describe these ligand exchange reactions by simulating a nanocrystal surface that is exchanged with ligands until thermodynamic equilibrium is reached. We have previously utilized this model to quantitatively describe the effects that both aliphatic chain length and geometry can have on exchange reactions. Using an Ising model framework would prove ideal for testing the effects of curvature because it accounts for inter-ligand interactions and composition dependent surfaces. In a related work, we have also observed that a small angle feature in powder X-ray diffraction patterns of colloidal quantum dots is related to the ordering of coordinating surface ligands. 6 X-ray diffraction patterns could provide additional information about the crystallinity of nanocrystal ligand shells during exchange reactions. To inform this hypothesis, diffraction measurements of colloidal nanocrystals would need to be acquired in solution, which is challenging.