Although the current software packages afford a great deal of flexibility in representation and visualization styles, they lack intuitive manipulations because of their reliance on a mouse and keyboard. The proper representation of biomolecules in a 3D space is crucial to the understanding of various intermolecular interactions. However, 2D displays can misrepresent the understanding of such interactions in 3D and the steep learning curve to manipulate structures is a bottleneck for widespread use of tools beyond scientists . Conversely, physical models avoid these pitfalls by offering an environment where users can manipulate objects intuitively whereby anyone can manipulate physical model by bending angles, breaking bonds, adding new atoms and functional groups, and changing positions of multiple atoms by rotation around one or more bonds. However, the physical models for larger complexes are expensive to make, hard to maintain, and lack real-time feedback to understand molecular interactions. We believe that the intuitive nature of physical models needs to be incorporated into in silico 3D modeling software; a feature that can be accomplished with the application of Virtual Reality (VR) hardware.