As binding energy is not the only consideration for drug candidates, Drugit puzzles make extensive use of 'objectives', i.e., additional bonuses and penalties which are added to the players scores for system properties such as molecular weight, topological polar surface area (TPSA) 20 , clogP , number of hydrogen bond donors or acceptors, identified structural alerts, or synthetic accessibility . These metrics are currently mostly calculated through the RDKit library . The importance and thresholds of each of these settings can be adjusted on a perpuzzle basis. In addition, most objectives come with a visualization which can highlight those atoms or regions which are causing a sub-optimal score for a particular objective.