Molecular weight criteria between 300 to 550 g/mol maintaining logP< 4, were added for additional evolutionary dockings. Using both ADV or DW abaucin-docking cavities, thousands of abaucin-children fitting their corresponding A.baumannii LolCE cavities predicted higher affinities (Figure , horizontal dashed blue line) than those predicted for the abaucin-parent (~ DW dockingscores < -78). The number of raw-children generated per experiment varied from 33387 to 46067 with different molecular weight targets (Table ). The percentage of raw children predicting best fitting to the criteria mentioned above were almost constant since only varied from 14.5 to 15.4 %. Fitted children that were non-toxic varied from 15.4 to 69.8 %. The children predicted with nonrestricted and < 550 g/mol molecular weights, predicted the highest affinities as shown by analyzing their rank profiles of docking-scores vs docking-score order (Figure , red stars and spheres). The children predicted with non-restricted and < 550 g/mol molecular weights, were selected to further studies.