Mexico stands out as a significant player in NP research. This prominence is unsurprising, given Mexico's second-place global ranking for scientific output in the study of NPs, trailing only behind Brazil, according to the 2023 bibliometric analysis by Alarcón-Ruiz . This dual distinction underscores Mexico's pivotal role in the field and highlights its potential as a key contributor to the further development of NPDBs. This, Mexico has made significant strides in NP research with the establishment of a NPDBs such as BIOFACQUIM , a curated database with 605 molecules, and the UNIIQUIM database, boasting over 1600 molecules. However, BIOFACQUIM still lacks a user interface and a filtering system, hindering users from searching based on chemical descriptors of pharmaceutical relevance or employing a structure similarity search. Therefore, there is a need for a comprehensive and user-friendly Mexican NPDB, filling a critical gap and furnishing researchers with a more efficient platform for exploration and discovery.