Acid-Docetaxel prodrug. DTXL (50 mg, 6.19×10 -5 mol) and DMAP (12.38×10 -5 mol) were dissolved in 15 ml of anhydrous dichloromethane in a 50 ml round-bottom flask. The reagents were stirred for a few minutes in nitrogen atmosphere at 0° C. Then Oleoyl chloride (14.7 µL) was added dropwise to the mixture followed by stirring for 4 h under nitrogen atmosphere and the temperature was maintained at 0° C to produce the mono-substituted (2ʹ-oleicdocetaxel). The conjugation of oleic-docetaxel was monitored by thin layer chromatography (TLC) using dichloromethane:methanol (97:3) as a solvent. The formation of DTXL conjugate was verified using 1 H nuclear magnetic resonance (NMR). The reaction mixture was diluted with diethyl ether and washed first with 5% HCl and then using brine. The solution of 2ʹ-oleoil-docetaxel was collected and filtered to remove the impurities. The product was finally dried under low pressure and stored at 0°C. The collected solution was dissolved in dichloromethane and purified using a silica gel column with dichloromethane: methanol (9:1) as the mobile phase to obtain the pure conjugate product.