For each molecule labeled as No.1-14 listed in Table and Scheme 1, three different sets of CG parameters were parameterized by the EVC-based LJSPM with the EX1, EX2, and AEX approaches respectively. Then the homogenous solution system of each molecule parameterized by different methods was constructed and relaxed by MD simulations respectively. Figure shows the comparison of the average density between these CG models and the corresponding AA model respectively.