The synthetic feasibility was estimated with the SAscore which considers the complexity of the molecular fragments, stereocomplexity, and molecule size. The synthetic feasibility is positively correlated with the SAscore, i.e., highest SAscores is associated with a higher synthetic feasibility. In this work, approved drugs and COCONUT presented mainly SAscores between two and three (Figure ). The accumulation of SAscores of approved drugs and COCONUT in the same zone can be attributed to the fact that a large proportion of the approved drugs are NPs or NP-based molecules. The LANaPDB compounds have mostly SAscores around five, which implies that a significant proportion of the LANaPDB compounds have a higher synthetic feasibility than the approved drugs.