Nasal passage cells were taken from chronic rhinosinusitis samples developed by allergic inflammation. The significantly overexpressed genes and potential therapeutic targets in nasal goblet secretory cells were ATP1B1, CD55, ELF3, EPAS1, and TNFSF10 (Figure ). Additionally, the most significant GO molecular functions (FDR < 0.001) were MHC class II protein complex binding in ATP1B1; virus receptor activity in CD55; DNA-binding transcription factor activity in ELF3; DNA-binding and RNA polymerase II cis-regulatory region sequence-specific DNA binding in EPAS1; lastly, cytokine activity and TNF receptor binding in TNFSF10 112 .