The new radii were optimized explicitly for water, so it is not a priori clear whether they o er more accurate results for other solvents. Table shows the RMSE values for all, neutral, cations, and anions for the other polar solvents in the MNSOL data set, acetonitrile, DMSO and methanol for the original SMD radii and the corresponding re-optimized radii ( †). In addition, corresponding combined RMSE values are given for the remaining 88 mostly non-polar solvents in the MNSOL data set, for which only data is available for neutral molecules. It is clear from this data that the new radii sets lowers the error of the predicted solvation free energies for the other polar solvents and has a negligible e ect on the accuracy for the non-polar solvents.