demonstrated that polymer carbonyl moieties acting as hydrogen bond acceptor were highly sensitive to presence of curcumin (a proton donor). After a certain curcumin feed, the amide groups of hydrophilic corona also start to involve in solubilizing the cargo, leading to physical crosslinking and finally causing colloidal instability and precipitation of the whole system. In the case of POx/POzi based amphiphiles library, Lübtow et al. observed that the drugs with higher proton donor count yielded the highest drug loading and vice versa, however the library was relatively small consisting of only 5 hydrophobic compounds . Herein, no correlation was observed between high proton donor count in drugs structure and higher drug loading. Out of 21 drugs, bortezomib which has the highest number of proton donor group i.e. 4 (Table ) has shown the intermediate loading capacity of 32 wt.% (Table ) while the two other drugs i.e. clotrimazole and mitotane having zero proton donor groups (Table )