A tube was charged with a picolinamide (1 eq), CuBr2 (10 mol%), Pd(OAc)2 (5 mol%), CsOAc (4 eq), tAmOH (1 M) and an aryl iodide or bromide (4 eq). The tube was sealed with a PTFE lined cap and heated to 140 °C for 24 hours. The reaction mixture was then cooled and filtered through a pad of Celite®, washing with EtOAc. The filtrate was concentrated in vacuo and the resulting crude residue purified by flash column chromatography.