We perform 20 different GA searches using the HTVS scoring function for each target. With a population size of 400 this generates up to 8000 different potential binders for each target in the final populations ) without any structural screening (GA), with the group-filters (+Filter), with a heuristic synthetic accessibility score (SA), and with both Filter and SA. The HTVS scoring methodology is used except for CM(SP) where the SP scoring methodology is used. Columns 6 and 7 list the corresponding number molecules with scores lower than -9.0 and -10.0 obtained with +Filter+SA. The last three columns list the corresponding number of molecules obtained by docking all the molecules from the 250K ZINC subset.