We have conducted all our simulations using Gromacs-2020.5, 91,92 PLUMED-2.7.2 and the Martini 3 coarse-grained model. Molecular dynamics simulations used the semi-isotropic NPT ensemble and a time step of 20fs in all cases. The temperature was set to T=303.15K and was controlled by a V-rescale thermostat with a coupling constant of 1ps. The pressure was set at 1.0bar with the compressibility equal to 3x10 -4 bar -1 , using the Parrinello-Rahman barostat with a 12ps time constant. Neighbor search used the Verlet cut-off scheme with a buffer tolerance of 0.005kJ/mol/ps and an update-frequency for the neighbor list equal to 20 steps. Periodic Boundary Conditions (PBC) were used in all directions. Coulomb interactions used the reaction field method with a cut-off of 1.1nm and a relative dielectric constant of 2.5 (see supporting information for an energy profile using a relative dielectric constant equal to 15). Van der Waals interactions followed the cut-off scheme set to 1.1nm.