2), the acceptance ratio and the scaling protocols obtained with the standard (Eq. 3) and adaptive (Eq. 4) HREM approaches. As observed for the case of compound 1 (see Sec. 4.1.1), the use of the adaptive scheme Eq. 4 for acceptance ratio equalization leads to an overall decrease of the mean P acc dropping to 18.3 from 28.0. Nonetheless, ratio equalization has a positive effect on the measured flux with a mean deviation from ideality (∆f up ) decreasing to 0.09 from 0.07 of the standard HREM algorithm based on Eq. 3. Replica flow improvement with Eq. 4, while marginal for compound 1, is significant in compound 2 where the torsional barriers for sidewall flipping are much higher than they are in the host 1 (see Figure further on). As shown in Table , where metrics for the HREM efficiency in the simulation of compound 2 are collected the adaptive algorithm in Eq. 4 has a positive and significant effect on the mean round trip time.