A compelling property of the present cross-catalytic reaction scheme lies in its ability to be triggered not only by H2O2 but also any redox cycling compound (i.e., by definition a redox-active compound able in the presence of O2 and a reducing species to cycle and to generate reactive oxygen species). This makes this approach potentially attractive for the design of new sensitive bioassays. This can be for instance through the upstream production of a redox cycling compound via an enzyme or an enzymatic label, which can then trigger via one of the above boronic probes an exponential molecular amplification. With the aim to evaluate the ability of P3 to be triggered by low concentrations of a given redox cycling compound, we have investigated the autocatalysis in the presence of different concentrations of 2-amino-3-chloro-1,4-naphthoquinone (from 0.15 nM to 0.15 µM), a compound we had previously identified as an efficient redox cycling compound. The results gathered in Figure demonstrates particularly good analytical performances, allowing to easily detect as low as 150 pM of 2-amino-3-chloro-1,4-NQ in less than 30 min, with a LOD estimated close to 50 pM. As for H2O2, the dynamic range of concentrations is also wide, extending over nearly 3 orders of magnitude. These analytical performances are definitely much better than those obtained with H2O2. This asymmetry in the analytical performances was shown to be an intrinsic property of a cross-catalytic reaction scheme. Indeed, if the two catalytic loops have similar rates, the detection efficiency of the catalyst of Loop 1 or Loop 2 is theoretically the same, thus leading to an identical LOD of each trigger. On the other hand, if the rates of each loop are different, the trigger of the fastest loop becomes the most easily detectable and therefore the one that theoretically leads to the lowest LOD. This is exactly what we observe here with the trigger naphthohydroquinone, which, due to its involvement in a faster catalytic loop (Loop 2) is detected more sensitively than H2O2.