Virtual screening was carried out using the "Longleaf" high performance computing cluster at the University of North Carolina. The Entire 2023Q2 release of the Enamine REAL space , approximately 37 billion compounds, was screened over the course of 2 days using 800 CPUs, for a total of 38,400 CPU hours compute time. Only the GBT-Small model was used for virtual screening to save on compute cost.