The present investigation determined that tau protein has the capacity to transpose telomere fragments to promoters and enhancers, resulting in mutations. These mutations render transcription factors and RNA polymerase II incapable of forming a stable bond, thereby diminishing transcription efficiency. Tau protein, as the aging device, which speeds up aging, uses a telomere-guided copy number reduction regulation mechanism to lower the number of copies of useful genes. Instead of using a cascade regulation method, this process might utilize an indirect gene expression regulation method, which relies on the interaction between specific DNA sequences and proteins. The mechanism relies on telomere RNA sequence-guided telomere transposition to precisely regulate gene expression, reduce the copy number of effective genes, and induce promoter and enhancer mutations. This mechanism is highly adaptable and progressively reduces the copy number of unnecessary or harmful genes, thereby promoting the adaptive evolution of organisms.