Supporting Information is available free of charge and includes additional synthesis schemes; signal assignment and NOESY spectra for AS4; vt-NMR spectra for 14a; representative immunoblots from initial degradation assay screening of AS1-AS7; representative immunoblots of time-course and mechanistic treatment for AS1; BET-HiBiT kinetic degradation for AS6; additional native gel data; general experimental details and compound characterisation.