The eBook is thus a comprehensive reference for optimising assays with the goal of developing probes that modulate the activity of biological targets, pathways or cellular phenotypes (see later section on probes) and of course candidates for drug discovery and development. There are many sections in the manual but those on mitigation of assay artefacts and interferences, statistical validation of assay performance parameters, data standards for reporting the results of screening and SAR assays and in vivo assay validation provide critical guidance for ADEV. There is also a useful chapter entitled 'Early Drug Discovery and Development Guidelines: For Academic Researchers, Collaborators, and Startup Companies' (2016, NBK92015).