Preparative scale syntheses of the 2-F products were also carried out (Scheme 4C/D). For these reactions several alterations had to be made to the reaction conditions. To overcome issues with oxygen limitation posed by the oxidase, the concentration of substrate was decreased to 10 mM and the reaction was carried out as a series of smaller volume biotransformations (10 x 500 µL). For 2-F-L-lyxose-5-phosphate 19a a conversion of 62% was obtained whereas the 2-F-D-ribose-5-phosphate 19b was generated with a conversion of 46%.