In a bid to increase the early enrichment and robustness of structure-based VS, we explored various consensus strategies that derive the ranks of the compounds from the predictions obtained with both pose sampling methods in combination with either or both scoring functions. Among all explored consensus strategies (reported in Table ), averaging the compounds' ranks obtained with Vina+Gnina and DiffDock-L+Gnina fared best. With an average BEDROC score of 0.38 and an average EF1% of 19.33 across the 43 targets, this consensus setup outperformed the best individual VS setup (i.e., Vina+Gnina, with an average BEDROC score of 0.36 and an EF1% of 17.88; Table ). The consensus scoring setup recovered, on average, the highest ratio of active scaffolds (20.64%) among the top-1% ranks. It also increased the number of targets for which BEDROC scores ≥ 0.5 were obtained from 12 to 17.