During the last few decades, numerous drug discovery programs focused on marine-derived microbial natural products due to their great potential for the production of structurally diverse biologically active secondary metabolites . Among the hot microbes responsible for the production of interesting compounds, fungi, served as the primary source for mining the first reported antibiotic, penicillin, whereas they are still one of the main sources for discovering novel bioactive compounds from different niches including the marine fungi which have high biological diversifications . Therefore, the bioactive secondary metabolites recovered from the marine-derived fungi have gained great interest as promising sources of therapeutics.