The ADMET properties of the 40 cannabinoids were performed using QikProp version 4.4 integrated into Maestro (Schrödinger, LLC, New York, 2015) which predicts the widest variety of pharmaceutically relevant properties: QPlogS (predicted aqueous solubility), QPlogHERG (Predicted IC50 value for blockage of HERG K+ channels), QPPCaco (predicted apparent Caco-2 cell permeability. Caco2 cells are a model for the gut-blood barrier), QPlogBB (predicted brain/blood partition coefficient), and % Human Oral Absorption (Predicted human oral absorption in gastrointestinal tract on 0 to 100% scale). The calculated physicochemical descriptors are displayed in Table -SI. QikProp bases its predictions on the full 3D molecular structure and the global minimum energy conformer of each compound was used as input for ADMET properties.