Figure shows three molecular fragments (fragments A, B, C) that appear more frequently among SA Unsynthesizable-Wrong molecules when compared to SA Synthesizable-Correct molecules. Each fragment is accompanied by two examples from the SA Unsynthesizable-Wrong molecules that contain it, and are numbered with the fragment letter (e.g., fragment A is contained in molecules A1 and A2). Because fragments clearly show where a moiety is cleaved, visualized using wavy lines in fig. , we can distinguish the success rate between otherwise similar molecular features that would experience differing inductive effects. For example, while SA Score may correctly predict the influence of fluorine, which is contained in 672 SA Unsynthesizable-Correct and SA Synthesizable-Correct molecules, as part of some molecular environments, molecules containing secondary alkyl fluorides, seen in fragment B from fig. , make up 12% of the SA Unsynthesizable-Wrong set and are never present in the SA Synthesizable-Correct set (i.e., never predicted correctly). We hypothesize that molecules containing fragment B, like molecule B1, may benefit from the fluorine gauche effect, an effect that can be captured through electronic structure calculations. Others benefit from inductive effects of the highly electron withdrawing group. Notably, E min does not make wrong predictions for molecules that contain this fragment. Similarly, SA Score correctly predicts many nitrogen containing molecules containing (10,450 molecules in the SA Synthesizable-Correct and SA Unsynthesizable-Correct sets), yet primary ketimines, fragment A, are present in 35% of the SA Unsynthesizable-Wrong molecules and only 12% of SA Synthesizable-Correct molecules. While SA Score, then, is capable of predicting molecules with primary ketimines correctly, it is less likely to do so if the group is a part of a ring or if the molecule, like molecules A1 and A2, is resonantly stabilized through the group. Fragment C may be evidence of SA Score overestimating destabilizing effects such as ring strain. We find several substitution patterns for the cyclopropylmethyl group (e.g., one such example in fig. ) which result in fused rings that are synthesizable. Interestingly, ring strain is often elucidated by contrasting energies between closed-and open-ring constitutional isomers, which is a natural consequence of the E min methodology.