Docking scores have known limitations in their ability to rank compounds correctly and identify true actives. When an approach can enrich actives over property-matched decoys on a small scale, this has been previously shown to translate to the ultra-large scale. For the GAK target, where experimentally confirmed actives were known, we validated the enrichment ability of the Glide HTVS protocol. It should be noted that the HASTEN protocol is, by definition, most useful when the chosen docking approach can, as in the case of GAK, successfully enrich in true actives.