Respiratory infections tend to follow predictable seasonal patterns in temperate climates . In colder months, individuals spend more time in enclosed spaces indoors which can lead to increases in the spread of infectious diseases. As a result, the total prescribed AA mass is often higher in winter-particularly for macrolide, penicillins and cephalosporin classes . Furthermore, lower loads of ERY in wastewater, compared to CLR, may be due to the preferences of prescribing CLR over ERY due to better tissue penetration, fewer side effects and greater patient compliance . ), however care must be taken drawing conclusions regarding differences in these samples due to the limited number of samples collected (n=1 each month). Proteobacteria was the dominant phyla in both samples (at 46% and 47% of total phyla detected for November and March respectively), with the next dominant reported as Firmicutes, at 25% in both samples. These are both frequently reported as the dominant phyla in influent wastewater . It has been reported in several studies that horizontal transfer of resistance genes occurs in several bacterial phyla, including Proteobacteria, Firmicutes and Bacteroidetes . Furthermore, these phyla are known to be significant reservoirs of mobile ARGs and integrons . The high density of bacteria in influent wastewater coupled with the chronic exposure to sublethal concentrations of AAs have led to WWTPs as hotspots for AMR . Regarding potential pathogens of concern, the bacteria Pseudomonas aeruginosa was detected in March 2019. The carbapenem resistant Pseudomonas aeruginosa, is a pathogen that has been highlighted by WHO as a bacterial species where there is a critical need to develop new AAs to treat infections (World Health Organisation, 2017).