In organic synthesis, it has been found that phosphonodithiolate, a compound with two P-S bonds, can be synthesized in organic solvent . However, the synthesis of phosphonodithiolate or phophothiolate remains quite limited . Here we reported a reaction which can create the bonding between P-S between thiol and T3P and can significantly drive the formation of non-equilibrium molecular organization. This research gives important clue about how primitive reaction cascade drive the formation of chemically fueled compartmentalization.