What this thus cannot provide is a hard and fast classification into feasible and unfeasible reactions. What it does provide are data points for initial scoring of predictions. Given the large amount of data returned by the link prediction, metrics are required which can be used to decide which reactions to focus on and which to perhaps save for a later stage. Undoubtedly there will be approaches yielding greater fidelity or insight into the feasibility or required processes. These will, however, require a greater investment of time and thus may not be suitable for this early stage of analysis.