Next, we study the importance of various features measured by the mean reduction in the Gini Index of the RF classifier. We present the results of feature importance scores associated with all physiochemical properties of compounds in Figure . The relative importance of various features when the Stdval, the The top three therapeutic groups identified in the dataset are Group N--Nervous System, Group C--Cardiovascular system and Group A--Alimentary tract and metabolism. We present the feature importance for these categories in Figures , and 8 respectively. Through all these figures, we find that independent of therapeutic area, bioactivity features, Stdval (min, and median values), are ranked at the top. The maximum value of Stdval seems to have a strong bearing in the prediction of the outcome of clinical trials for the therapeutic classes of the nervous system and the alimentary tract and metabolism.