With MFCC-MBE(2), the errors in the protein-ligand interaction energies are in all cases significantly reduced compared to the conventional MFCC scheme (except for 1TOW with ε = 79.39, where MFCC accidentally shows a very low error). In the calculations with ε = 4, the largest error is obtained for 1TOW with 58 kJ/mol (but for this test case, the error is very dependent on the chosen ε, while in all other cases, MFCC-MBE(2) achieves errors below 20 kJ/mol. In the calculations with ε = 79.39, the largest error is obtained for 2PK4 with 51 kJ/mol, while for all other test cases, the errors are below 32 kJ/mol.