Vina Scores were used for ranking and selection in Autogrow4. STgrow4 uses both Vina Scores and LogBB values for ranking and selection. The same target structure, fragment library, reaction library, filters and parameters were used for both Autogrow4 and STgrow4, except for W. The relative weights for Vina Score and LogBB can be controlled in STgrow4 with the W parameter.