Moreover, the challenges associated with the use of artificial intelligence for health and diseases has also been discussed . Some of the mRNA vaccines have been developed with such abilities against the pandemic. Furthermore, various other techniques including ML, AI, databases, Bioinformatics, and computational biology have the potential for the automation of universal pandemic vaccines. The current review aims to highlight the potential role of GPCRs and kinases and their signaling pathways in immunology and different parts of the viral life cycle. Moreover, it also highlights the potential of these pathways to be targeted for vaccine development against these viruses. Furthermore, the paper also describes the need for a universal pandemic vaccine as these viruses and highly mutant. Beyond that, it also describes some potential techniques that have been utilized up till now for the automation of universal pandemic vaccines.