degradation will be reduced. The highest drug loadings can be found for P1 and P2 with a DLm of almost 90 wt% (see Figure ). This is very high even when compared to high drug-loading porous materials with maximum values of 35 -70 wt%. Since our carrier-material, the Nmethylimidazole-backbone, is much smaller and lighter than the drug, high drug-loading can easily be achieved in our prodrug nanoparticle approach. It needs to be pointed out that an ideal linear P1 polymer would have a maximum DLm of 85 %. Therefore, our experimental data suggests that the polymer is branched or crosslinked inside of the nanoparticles, allowing a larger fraction of prodrug monomers than co-monomer in the particles and therefore higher DLm values than expected for a linear polymer. Previous work corroborates this crosslinking of imidazole during DAP. However, besides the high drug loading for P1 and P2, these conditions also show the largest range between the minimal and maximal DLm. This can be explained by correlating to the overall particle yield (see Table ). The particle yield is taken from the overall decrease of the peak area found in the HPLC chromatograms of the reaction medium at the start and end of the nanoparticle synthesis (at 254 nm). In the approaches P1 and P2, less monomer is consumed.