Furthermore, the biocompatibility of collagen-furan samples was assessed via histological analysis of subcutaneously implanted samples (Figure ). Hematoxylin and eosin (H&E) staining revealed slight to mild accumulation of lymphocytes in the adjacent tissues of samples at day 5, moderate inflammation at day 28, and rare scattered lymphocytes at day 56 postimplantation. However, no other inflammatory factors, such as giant cells or macrophages, were observed at any time point. Staining also indicated that the mean rate of fibrosis was mild at day 5, with no apparent signs of fibrous tissue formation at day 28 and day 56. The mean rate of edema was mild at day 5 and completely disappeared at day 28 and 56. Notably, granulation tissue was absent at all time points, and congestion was only observed at day 5. Integration between the samples and their adjacent tissues was visually apparent in all rats at all time points and further confirmed by staining at day 5 (Figure ).