Fungal species from the world's tropical climates have recently drawn a lot focus in scientific research due to the potential application of their secondary metabolites in drug research. Notably, Basidiomycota have proven to be a vast reservoir of biologically active secondary metabolites, especially pleuromutilin derivatives, which are the last class of antibiotics that entered the market for systemic human therapy and have recently raised substantial attention. In addition, recent reports reveal the potential application of Basidiomycota metabolites in neurodegenerative diseases (NDDs) treatment owing to their NGF-potentiating and/or NGFmimicking effects. NDDs result in progressive malfunction of the nervous system and affect millions globally, with more than $600 billion incurred in their management. In our ongoing efforts to find new pharmacologically useful agents, we have recently focused on the African species of this fungal division. Thus, our current study focuses on the neurotrophic activities of the drimane-type molecules isolated from a Polyporale, Abundisporus violaceus. The research was motivated by previous reports on the neurite-outgrowth stimulating potential of drimane sesquiterpenoids isolated from Cyathus africanus and C. stercoreus on NGF-mediated PC-12 cells. The genus Abundisporus was first described by Ryvarden in 1998 in the family Polyporaceae. Currently, it comprises nine species that are distributed mostly in tropical and subtropical regions. Abundisporus species belong to the numerous taxa of Basidiomycota that have not been studied for the production of secondary metabolites, and hitherto there are no reports on the chemical composition of the basidiomata or the corresponding mycelial cultures of the genus. We have recently collected and cultured a specimen of A. violaceus (Wakef.) Ryv., a species that has also been recorded from Zimbabwe, Tanzania, Uganda, Brazil and China. In this study, we report spectral data of compounds 1-8 in addition to their bioactivity in antimicrobial, cytotoxicity and neurite outgrowth effects assays.