The final compounds we elected to synthesise using our new synthetic approach are compounds 10 and 11. Like the halogen containing compounds discussed previously, both compounds are reactive under the hydrogenolysis conditions previously employed in the synthesis of RM734 making them difficult if not impossible to obtain using the previously reported methodologies. The transitional temperatures of compounds 10 and 11 are shown in Table . Compound 10 may be compared to the parent RM734 molecule with an additional olefin inserted between the ester-link and left-hand ring. Inclusion of the unsaturated moiety significantly increases the melting point and N-I transition temperature and sees the extinction of the NF phase. The increase in melting point and isotropisation temperature probably results from both the increased molecular length and the enhanced intermolecular interactions (relative to RM734) that result from incorporation of the cinnamate unit. The short range of supercooling precludes the observation of a monotropic NF phase. Compound 11 shows an enantiotropic NF phase which transitions directly into the isotropic phase. The replacement of the 2,4-dimethoxybenzoate with 2-ethoxyfuran-5-carboxylate leads to dramatic increases in the meting point and the onset of the NF phase, with 11 exhibiting a direct NF-Iso transition. As will be shown shortly, the later is probably a consequence of increased electric dipole moment.