The humoral immune response plays a main role in the clearance of cytopathic viruses and its memory response prevents reinfection. According to Huang et al. and Wu et al., IgM, IgA, and neutralizing IgG antibodies can be detected in 12, 14 and 10-14 days, respectively, after symptom onset on average, suggesting that SARS-CoV-2 causes a robust B cell response in the majority of COVID-19 patients . Indeed, antibodies binding the RBD of the S glycoprotein can have neutralizing properties, blocking virus interactions with the human protein receptor ACE2 , thereby inhibiting/preventing target cell infection. The B cell response to SARS-CoV-2 protects from the primary infection and extends immunity against reinfection due to memory B cells that can respond quickly by producing high affinity neutralizing antibodies. However, it is yet impossible to predict the duration of memory responses due to the timing of the COVID-19 pandemic.