The AHAS Inhibition in plants through the use of herbicides is regarded as one of the safest to human ways of plant control because the biological pathway of branched-chain amino acid production doesn't exist in humans. However, mass use of an herbicide can promote resistance, or immunity, and generally will lead to lessening effects of use even with combined inhibitor treatments. Single-point amino acid mutations within the genome, i.e., simple ones, of the AHAS enzyme have been investigated in a number of plant species and in different amino acids with regards to resistance to these commonly used herbicides, e.g. in .