A key intermediate in ozonolytic cleavage of alkenes is the peroxyketal 3 . Access to peroxyketals can be achieved through ozone-based approaches, albeit this approach comes with some challenges. Ozonolysis on an industrial scale can be dangerous and impractical, although flow chemistry apparatuses can alleviate some of the challenges faced on scale. Additionally, unwanted reactivity of ozone with other oxidizable groups can limit reaction practicality in many systems. A synthesis of shearilicine by our group involves the hydrodealkenylation of an isopropenyl group, but such removal must be accomplished early in the route to avoid unwanted side reactivity with both the furan and indole moieties encountered later (Figure ) . The ability to remove isopropenyl fragments later would enable the broader use of dealkenylation as a general strategy in multistep synthesis.