We tested our design hypothesis described above against WT TTR□ and A108G TTR■ homotetramers and evaluated the slate of benzoxazole derivatives (3-8) listed in Scheme 1. The design rational for 3 and 4 has already been discussed above. Compounds 7 and 8 were designed to improve the emission intensity through substitution of the Cl groups with isosteric Me groupsbecause halogen atoms can increase the efficiency of non-radiative processes (i.e. intersystem crossing, "heavy-atom effect" 29 ). Finally, 5, 6 and 8 are isomeric in the position of the carboxylic acid. Towards these goals we tested our design hypothesis described above against WT TTR□ and A108G TTR■ homotetramers and evaluated the slate of benzoxazole derivatives (3-8) listed in Scheme 1. The design rational for 3 and 4 has already been discussed above. Compounds 7 and 8 were designed to improve the emission intensity through substitution of the Cl groups with isosteric Me groups-because halogen atoms can increase the efficiency of non-radiative processes (i.e. intersystem crossing, "heavy-atom effect" 29 ). Finally, 5, 6 and 8 are isomeric in the position of the carboxylic acid. Towards these goals we tested our design hypothesis described above against WT TTR□ and A108G TTR■ homotetramers and evaluated the slate of benzoxazole derivatives (3-8) listed in Scheme 1. The design rational for 3 and 4 has already been discussed above. Compounds 7 and 8 were designed to improve the emission intensity through substitution of the Cl groups with isosteric Me groups-because halogen atoms can increase the efficiency of non-radiative processes (i.e. intersystem crossing, "heavy-atom effect" 29 ). Finally, 5, 6 and 8 are isomeric in the position of the carboxylic acid.