The corresponding DW-BEL-ADV grandchildren from 16153 and 46808 predicted improved affinities only when generated from 16153 (Compare Figure , red circles with Figure , green circles, and Table , 16153 and 46808-grandchildren). To test whether grandchildren affinities could be further incremented (lower docking-scores), additional co-evolutions were performed from the 16153 parent using increased number of consecutive runs. Because during consecutive runs, memories are kept for each of the raw-and fitted-grandchildren, their affinities (lower docking-scores) are expected to increase for each additional run. The maximal number of runs was limited to 3 by the computer memory actually available (120 Gb). The docking-score profiles monitored by plotting them versus the fitted-grandchildren ID number predicted that the co-evolution of 16153 for 3 consecutive runs maximized their final affinities (Figure , red circles). These improved DW-BEL affinity results were confirmed by ADV docking (Figure , red circles). However, because two different scaffolds, one each for 2-and 3run profiles, were generated, one representative top-grandchild from each of the profiles were chosen for additional studies.