STRENDA DB is a database on enzyme-catalyzed reactions, which covers the most important information on reaction conditions and kinetic parameters. The API was used to create an EnzymeML document from a STRENDA DB entry via a STRENDA DB-specific thin API layer (TL_STRENDA) to the object layer using the PyEnzyme library. The resulting EnzymeML document was then created by the API (see SI 3.2).