In recent years, several synthetic micro-and nanoscale systems have been described that can move in fluids thanks to the application of an external energy source such as magnetic, 22 light, or ultrasonic fields. Other important examples of micro/nanomotors include those driven by chemical reactions between the surface of the motor and a chemical propellant present in solution. A classic example in this regard is the use of catalytic surfaces such as platinum to decompose H2O2 in a solution and generate bubbles that propel the micromotor forward. More recently, enzymes have also been used as powerful catalysts to enable self-propulsion of microand nanomotors with biocompatible and bioavailable fuels. In this case, micro-and nanoparticles are functionalized with enzymes that catalytically convert a specific substrate into products, creating a chemical gradient around the particles that generates a driving force. These systems offer promising features for biomedical applications, such as the use of biocompatible and bioavailable fuels, chemotactic movement toward or away from chemical gradients, and the absence of external energy sources. Recently, enzyme-driven motors have also been equipped with pH-responsive DNA nanoswitches to create a device that is able to swim and simultaneously sense the pH of its surrounding environment. Despite the above advantages, such enzymedriven micro/nanomotors also suffer from some limitations. For example, the potential toxicity of their components (metals, silica, and polymers) may limit their application in clinical settings. In addition, it is not always easy to control the geometry and shape of the particles (especially at the nanoscale) in these materials, which could be critical for improving propulsion efficiency. Finally, it is also difficult to achieve efficient surface functionalization with enzymes and to control their distribution and concentration. To overcome the above limitations, we propose here to combine DNA structures with enzyme catalysis to build self-propelled DNA-based nanoswimmers (hereafter referred to as "DNA-enzyme nanoswimmers") that would enable easier surface enzyme modification, controlled degradability, biocompatibility, and shape flexibility. As a model system we used a tubular DNA structure and decorated it with a motor enzyme so that the DNA structure is able to move (swim) independently and unhindered in the presence of the enzymatic substrate (Figure ).