To further study the binding properties and discern differential steric effects across the series of compounds, only the 7-substituted indolyl carbamates were studied in silico. To generate non-covalent docking poses that were in line with the known SARs, as well as the available structural data on this series of ligands (e.g., the crystal position of the cycloheptyl ring), several constraints had to be introduced (see Experimental Section); finally, two predominant binding modes were identified (cases A and B).