Understanding hydrogen bonding (HB) interactions between organic molecules and water molecules is central to unravel the poorly understood mechanisms of AOC. For example, it has been proposed that a group of accelerated reactions in aqueous emulsions, called "on water" reactions, occurs due to HB stabilization of transition states relative to reactants. Also, countless chemical processes relevant to biology involve HBs between water molecules and organic substrates. In light of the importance of organic molecule-water cluster bonding, the present work focuses on the accurate quantum mechanical description of such interactions.