Noting the structural similarity of ligand 1Gal to previously published compounds possessing a bis-galactoside motif, such as 3 (Figure ), we hypothesised that 1Gal and its complexes also have potential for antiadhesive activity against fungus CA. 11,28,29 DFT calculations were carried out to predict the lowest energy conformation of 1Gal, and compare this with known CA adhesion agents. The most stable conformation in water (SMD method) was found to be a closed 'basket' configuration, analogous to that of the previously-reported molecules 3 and 4 with known fungal antivirulence activity. Calculated energies of the conformers and the inter-anomeric carbon distances in each correspond closely (Figure ). This result suggested that the dipicolonic amide derivative and its metal complexes have potential for anti-adhesive activity against CA. Complexation to metals gives access to topological presentation patterns inaccessible or difficult to access with purely organic molecules. Synthesis of dendrimers is difficult and time consuming, while assembling a Eu(III) complex presenting six galactoside epitopes like [Eu⋅(1Gal)3](CF3SO3)3 is trivial by comparison, and was anticipated to provide access to similar activity. Adhesins belonging to yeasts of the Candida genus are known and lectin-like interactions are recognised as one of the three types of adhesive interactions along with integrin mediated protein-protein interactions and as of yet undefined interactions. Lectin-like interactions on the surface of CA are commonly attributed to mannoprotein and fucoside recognition, with some examples citing GlcNAc as epithelial cell receptors as well, but to date the exact protein responsible for galactoside recognition in CA is not known, therefore the characterisation of the interaction at a molecular level is not yet possible. Nevertheless, a number of studies, including the data presented below, demonstrate that adhesion to human buccal epithelial cells (BECs) can be significantly inhibited by glycoconjugates with galactose epitopes (particularly divalent galactosides), providing potential medicinal value at early stages of infection.