The 2013 Nobel Prize in Chemistry was awarded to Karplus, Levitt, and Warshel for their pioneering development of a method to model interactions between a quantum mechanics (QM) subsystem and a molecular mechanics (MM) subsystem, giving rise to the innovative hybrid QM/MM theory. At the heart of QM/MM coupling is electrostatics, which could be the critical component in the development of new machine learning (ML) molecular mechanics frameworks (ML/MM).