Initially, we honed the system's ability to maintain a minimum reactor volume for simple solvent exchange conditions without complex visual elements (see SI for details). Our first challenge involved a solvent exchange distillation from a slurry of EDCI•HCl and triethylamine in acetone, mimicking a typical endpoint in a carbodiimide-promoted amide coupling reaction (Figure ). Acetone was distilled from the slurry, and butanone was added to enable solvent exchange for product isolation. The CV system recorded the volume and automatically introduced butanone when the reactor volume dropped below a specified threshold, ensuring the maintenance of a minimum reactor volume. This example demonstrated that HeinSight2.0 could serve as a visual PAT for monitoring and controlling distillation without human oversight. Both the primary parameter (volume) and secondary parameter (temperature) provided valuable information. The goal of maintaining a threshold volume was successfully achieved, as evidenced by the visual record and reactor volume trend. The rate of distillation was determined from the slope of the volume trend, which progressively and, the internal temperature of the reactor (red) was captured via the EasyMax temperature probe, while the reactor volume (purple) was returned from the CV system. The apparent spread in volume recorded by the CV system was due to variations in the liquid height due to fluctuation from mechanical agitation and boiling, which both changed the 2D cross sections presented to the camera; see SI for detailed measurement and control workflow. The volume trend data were visually emphasized by adding manual markers to guide the eye.