The main category of chemicals that are absent from the current exposome related chemical databases are the transformation products of anthropogenic chemicals. The structure-based molecular networks (SBMN), from drug discovery, combined with synthetic accessibility (computational synthetic chemistry) can be used to build the transformation tree of a chemical. The already well-known transformation products would provide the distance metrics for the SBMNs and the synthetic accessibility calculation would enable pruning of the trees from the structures that are impossible. Other data driven approaches such as generative models can also provide the means of building such transformation trees. Ultimately, the structures in the pruned trees can be added to the existing chemical databases.