The synthesis of optically active alcohols usually occurs in a chiral environment which is achieved via a chiral reagent, a catalyst/enzyme, or a chiral solvent. Since its discovery, the oxazaborolidine catalysts, also called Corey-Bakshi-Shibata (CBS) catalysts named after the scientists who discovered the reagents, have found enormous utility for the synthesis of chiral alcohols of high enantiopurity. The mechanism for the CBS-catalyzed non-symmetric ketones includes, the formation of the Lewis bond between the borane and nitrogen in the catalyst, the formation of the Lewis bond between the oxygen of the ketone and boron in the catalyst, and the transfer of hydride from borane to the carbonyl carbon (Scheme 2). Since the borane by itself can reduce ketones, and the catalyst is only present in small amounts, it is imperative that the reaction temperature is maintained at around 0 ˚C to ensure stronger Lewis bonds and that just enough or a lower amount of the ketone must be added at any given time to ensure contact with the catalyst. Hence a good ice bath and dropwise addition of the dilute ketone solution over a relatively long period is key to obtaining a high level of optical purity.