The selective pressure for reduced self-damage in higher species may explain why endogenous AMPs show some degree of cholesterol-induced selectivity . found that cholesterol, more effectively than lanosterol or ergosterol, prevents insertion of the toroidal-pore forming peptides LL-37(F27W) and Temporin L [387], likely due to its enhanced raft-forming , lipid-condensing, and membrane ordering abilities . However, the simple SOPC/Chol models used in these studies overlook lateral heterogeneity, a key factor of the effect of cholesterol on biomembranes .