Here, we present functional RNA droplets capable of performing two-input AND logic operations (Figure ). To maximize the design flexibility, we designed a multi-stranded RNA motif that can sense specific miRNAs. The rationally designed six ssRNAs self-assemble into a four-valency nanostructure furnished with two extensions. The four branches terminate in a hairpin loop of the same sequence, adapted from the KL sequence of viral genomic RNAs. The KL region contains a palindromic subsequence, which allows the self-assembly of network-like structured RNA condensate. To optimize the design of the sensing motif, we numerically and experimentally study the programmability of the KL interaction strength by engineering the palindromic subsequence. The two extensions bear a toehold region designed to bind with a cognate miRNA as a model input molecule, thereby initiating a strand displacement reaction. Upon inputs of both targets, the motif favors a dynamic separation into two sub-structures, causing a drastic phase change from liquid to dispersed states. The phase state of RNA condensates was determined by observing the coalescence dynamics and fluorescence recovery after photobleaching (FRAP).