In development of new materials for medical applications, biocompatibility and biodegradability are key parameters to consider, since the nature of the polymers, the duration of contact with cells or tissues, and the organs play a crucial role , . PBS is susceptible to degradation through hydrolysis, like other aliphatic polyesters, and its degradation by enzymes leads to the formation of non-toxic by-products indicating very good biocompatibility of PBS material . Enzymatic degradation assessments, typically conducted under physiological conditions (around 37°C and pH 7-7.5), exhibit a wide array of outcomes in PBS literature. Some studies report rapid and extensive PBS degradation within hours, facilitated by various lipases, while others demonstrate more moderate weight loss . In this study, we introduce a novel aspect to PBS-base polymers research, modifying PBS properties specifically target enzymatic degradation of PBS films, utilizing a lipase derived from Pseudomonas cepacia as our catalyst.