Due to its ease of use, the ALPB model has been used in numerous computational studies since its publication in 2021. However, the GFN methods and, therefore also, the ALPB model were not primarily designed to accurately describe free energies. Still, there have been a limited number of studies that directly assess their performance for high-throughput virtual screening applications, like dissociation constants or enzyme-ligand binding. While these studies generally provided promising results, they also revealed the shortcomings of the xTB methods, which could be addressed by re-evaluating the energies at higher levels of theory. Therefore, the usage of a multi-level workflow, where energies are calculated with high-level methods on lower-level geometries, is the common way for calculating solvation-dependent properties 153 with the help of the xTB methods.