COVID-19 patients who become critically ill as acquired methemoglobinemia develop refractory hypoxia and require red blood cell transfusions for treatment . The prevalence of beta-thalassemia heterozygotes is associated with COVID-19 immunity . Patients with sickle cell disease and laboratory-confirmed COVID-19 typically have a mild or insignificant course. They have a lower risk of intubation, ICU admission, or death but require a slightly more extended hospital stay . Severe COVID-19 Patients have lower hemoglobin levels than those with mild illnesses in some epidemic areas. And low hemoglobin levels can result in anemia and complications . HP*2 alleles protect specific individuals from the severe effects of COVID-19 and other infectious diseases through their anti-inflammatory response . The primary function of haptoglobin is to form a stable complex with free hemoglobin, which is then processed by the mononuclear-macrophage system. There is a correlation between low serum hemoglobin levels and increased ferritin and LDH levels . Due to the excessive hemoglobin phenotype, it is unknown whether patients with thalassemia are more susceptible to SARS-COV-2 or have a higher risk of COVID-19 complications than the general population .