ABPs remain a compelling area of research, particularly given the urgent need for solutions to counteract biofilm-related resistance. Evolution has naturally selected some of the critical features of effective ABPs, such as their compact structure. Highly potent ABPs have promising applications in the surface-coating of prosthetic and medical devices, where bioavailability is less critical. The biofilm environment, with its dormant cells and intricate cell-to-cell interactions, offers a unique context for discovering or designing peptides with novel mechanisms of action, such as reactivating dormant synthetic pathways to re-sensitize bacteria towards cell wall, protein, or DNA synthesis inhibitors. The use of (highly) coarse-grained molecular modeling approaches to study ABP interactions with ECM polymers may also provide structural insights that align with experimental findings.