Chitosan nanosystems due to their high adhesive characteristics and naturally positively charged features. Further, the choice of chitosan-lipid system is determined by the drug's affinity for the matrix. To improve drug association efficiency, a chitosan-lipid system and a drug with comparable affinities are selected.. The insulin is complexed with sodium docusate in the formulation via the chitosan-monoolein method. The process of complexation eliminates or reduces insulin's charge density, improving its affinity for lipophilic carriers. The synthesis of NPs comprising an insulin-sodium docusate complex embedded in chitosan-lipid matrix is predicted to boost the resistance of matrix and insulin to enzymatic degradation following its oral administration.