Trialdehydes G-U were each screened against 18 diamines, of which trialdehyde S was the best performing, with 6 (33%) combinations yielding the most desirable outcome of clean formation of a single topology. Trialdehydes I, P, Q and R also showed good reactivity, with trialdehydes I and R previously reported in organic cage formation, but P and Q being novel building blocks not previously reported as organic cage precursors. Trialdehyde O showed the least reactivity with 17 (94%) of its combinations with diamines affording no observed cage topology, followed by trialdehydes L and T, which saw no clean formation of either a single or mixture of topologies.