However, this is a limited approach as r in the active site is delocalized, while 𝐸𝐸 "⃗ (𝑟𝑟) exerted by the enzyme is heterogeneous in the active site volume. This motivates us to consider a 3-D approach for electric field analysis and comparison. Quantifying similarities and differences in 3-D vector fields is no meek task. Several algorithms have been developed, some focusing on detecting local features, and others focusing on global measures of similarity . We focus on the latter, as we wish to consider all features of 𝐸𝐸 "⃗ (𝑟𝑟) that could perturb r.