Further anthraquinone derivatives discovered from the marine fungus P. oxalicum, including citreorosein-3-O-sulphate (86), emodin-3-O-sulphate , and aloe-emodin were not tested for any relevant activity . However, other previous studies revealed that aloe-emodin On the other side, emodic acid (97) which was previously isolated from the marine endophytic fungus Eu. rubrum , evoked potent inhibition of p56 lck tyrosine kinase with an IC50 value of 1.07 μg/mL . In addition, compound 97 demonstrated a potent inhibitory effect on both the tyrosine kinase domain of the epidermal growth factor receptor (EGF-R) and protein tyrosine kinase p59 fyn with IC50 values of 0.078 and 0.080 μg/mL, respectively without any noted cytotoxicity on human foreskin fibroblast , (Figure ). . Noteworthy, compound 110 demonstrated remarkable brine shrimp lethality using Artemia salina with an LD50 value of 10 μM , while the parent compound 108, and its derivative 109 showed no lethality in the same study suggesting that brine shrimp lethality might be dependent on acetylation and/or glycosylation of this compound.