In each polymer series (A-pEtEtOx-A and A-pPrMeOx-A), the stability of most formulations follows the certain pattern. Exemplarily, CUR loaded M A-pEtEtOx-A and M A-pPrMeOx-A formulations are shown in Fig. , b. The formulations with a CUR feed of 1-8 g/L were relatively stable up to 24 h, less than 1 wt % loss in the LC was observed in both of M A-pEtEtOx-A and M A-pPrMeOx-A formulations. In the case of M A-pEtEtOx-A formulations (Fig. ), up to 4 g/L CUR feed, no reduction in drug loading was observed even after 60 days. In contrast, at 6 g/L CUR feed and above, a gradual but moderate decrease in LC was observed. Overall, the A-pPrMeOx-A formulations series behaves different compared to A-pEtEtOx-A series, but within the series all formulations behave very similar, with the notable exception of Ap RS PrMeOx-A at 10 g/L CUR feed (vide infra). Up to a CUR feed of 6 g/L, all formulations are very stable for 60 days (Fig. ). However, at CUR feed of 8 and 10 g/L, the concentration of CUR found in the supernatant increased gradually and quite significantly. For instance, at 8 g/L CUR feed M A-pPrMeOx-A formulation, a 10-fold increase in the drug loading (0.16 ± 0.04 g/L (day 0) to 1.66 ± 0.45 g/L (day 60)) was observed.