In the previous work (MMR, 2021a) we presented a new type of mirror symmetry, expressed through the number of atoms in the set of 20 protein amino acids (AAs), arranged by chemical similarity into two columns and 10 rows (Tables and) (Tables 1 in relation to Table ; Table in relation to Figure ); the 10 rows with 5 quarters (Table ) and two columns with 4 quintets (Table ). Mirroring itself is created by crossing the last column of the periodic system of numbers (PSN, Figure ) and the path of the largest change on the 6-bit binary tree (Table ). That fact alone justifies the title of this paper. Another reason for title justification lies in the fact that in most of the illustrations of that previous paper (MMR, 2021a) the unity of chemism and semiosis is presented.