The explicit dynamical interaction of the cavity DOF and the reaction coordinate should be taken into account explicitly, rather than integrating out as was done in Ref. 371 using k TST (Eq 196). Of course, the TST rate is only a very crude approximation of the rate constant, which explicitly assumes that once the reactive trajectory reaches the transition configuration, it will move forward to the product side (follow one direction) and no recrossing of the barrier nor turning back to the reactant side will occur. This is, of course, not accurate for reactions in the condensed phase where the solvent fluctuation can facilitate the reaction coordinate to recross the barrier many times before finally settling inside the product well.