In this case, we know that protein remodeling of residue F114 plays a role in unbinding but we note that interestingly this does not hamper the quality of the ranking. In Figure , we report the results together with experimental results. Another interesting aspect is that the correlation is again improved from RAMD to MetaD, as shown in the Supporting Information, illustrating how a method with reweightable kinetics can improve the information harvested relative to non-equilibrium simulation.