Transition metal catalysis has revolutionized the practice of modern synthetic chemistry, with significant impact in both academia and industrial settings. A hallmark of this important class of chemical processes is the diverse modes of reactivity enabled by metal-ligand interactions. This translates to the ability to synthesize a broad range of structurally distinct chemicals through the execution of on-target catalytic cycles. However, this supposedly appealing feature of reactivity diversity can also, inadvertently, result in the exit of originally catalytically active species to an undesired off-target reaction course and lead to off-loop catalyst dormancy or deactivation.