We have shown that imidazole provides a potential pro-moiety for amide-carrying TKIs. By incorporation of prodrug monomers into the backbone of degradable conjugated polymer nanoparticles, we provide a novel approach for ROS induced drug release. The light weight of the carrier unit enables high drug loading of up to 90 wt%, significantly higher compared to other state-of-the-art drug delivery systems. Moreover, the conjugated nature of the polyimidazole backbone in our particles allows direct imaging with photoacoustics and CLSM.