Enantiopure samples of "mechanically chiral" molecules, 1 rotaxanes and catenanes in which the mechanical bond provides the sole chirotopic stereogenic element have historically been produced by resolution of racemic samples 2 or unusual chiral building blocks, both of which typically rely on preparative chiral stationary phase HPLC (CSP-HPLC) separation of the product or building blocks, respectively. Although these methods have allowed preliminary studies on the properties of mechanically chiral molecules, 2f,g,3 the inherent limitations of CSP-HPLC has prevented more detailed studies of their applications.