However, one related compound seems to have achieved this feat. Sensorgrams derived from inhibition of DC-SIGN and L-SIGN by Man84 (Fig. ) show a high relative response without ligand (2500 RU for DC-SIGN and 2000 RU for L-SIGN), which decreases as the glycomimetic concentration increases, reflecting an inhibitory effect on lectins activity. For the same ligand concentration, we observe a huge difference in signal between the two lectins, where the L-SIGN response is inhibited much more rapidly.