The overall concept of the workflow that we present here is illustrated in Fig. . Precursor powders are mixed as aqueous slurries using robotic liquid dispensing into sacrificial well plates to form discrete solid pellets (after drying, compaction and calcination steps) which can be presented to automated instrumentation for characterisation. The overall effect is to increase throughput by automating some steps and modifying others so that manual actions now impact multiple samples, particularly during transfer between processes. This reduces the researcher time needed to achieve an equivalent volume of data, or enables richer data to be generated with equivalent effort. Particular focus has been given to the elimination of manual "one by one" operations and reducing handling to sets of multiple samples wherever possible. The retention of some manual handling and therefore inspection of the samples at intermediate points in the process gives flexibility and resilience, so that subsequent choices can be adjusted (e.g., calcination temperature or reaction atmospheres). In a research project whose purpose is the discovery of previously unknown materials and structures, a totally automated process may not be appropriate or proportionate, with the retention of manual steps adding flexibility for intervention to make changes based on learning, while automation is used to accelerate steps that are more readily engineered. The aim of the workflow set out here is discovery by screening, with precise measurement of individual hit compositions required in subsequent serial studies. workflow with the detail behind each step 1-7 provided in the Methods section. Milling of aqueous precursor slurries allows liquid handling robots to dispense and mix sets of mixtures that are then dried, compressed and calcined to enable presentation of discrete pellets of dense powder samples to X-ray diffraction or other forms of characterisation. b) The range of elements that can be used in the slurry based high-throughput workflow we describe for materials discovery or targeted materials synthesis.