Both routes shared the same key intermediates (4PA, TBPPC, APPCN, PPP) and the same reaction for the formation of the main scaffold of S-Zanubrutinib (step 5 of the benchmark route and step 6 of the route in Fig. ). The main difference was the priority of hydrolysis of nitrile and asymmetric resolution. In the benchmark route asymmetric resolution was performed before hydrolysis, while the order is reversed in the route found by CASP.