Thin-film freeze-drying (TFFD) is a rapid freezing method that utilizes a solid surface cooled with cryogenic temperatures to freeze samples. This technique involves dropping small liquid droplets onto the surface, which then spread and freeze within a very short time frame of milliseconds. Subsequently, the frozen thin films are dried through lyophilization, resulting in powders with favorable aerosol characteristics. These powders are characterized by their low density, large specific surface area, and brittle matrix structure. The technique of TFFD has been employed to create dry powders for the pulmonary delivery of small molecule drugs and vaccines. Recently, TFFD has been widely utilized for large molecules such as monoclonal antibodies, vaccines, and enzymes, as well as particulates like liposomes and small interfering ribonucleic acid (RNA) encapsulated in solid lipid nanoparticles. TFFD is advantageous for preparing dry powders of large molecules since it involves low shear stress, minimizing any potential detrimental effects as compared to spray freeze-drying and spray-drying techniques. The chief limitation is that any drug frozen using this method must be soluble in a solvent that works with this process, such as water and certain organic solvents.