As only the total energies of the quantum-chemical calculations for the monomers, dimers, trimers etc. enter in the eb-MBE [see Eq. ( )], it is straightforward to apply in combination with any quantum-chemical method. While for CCSD(T), the computational effort scales as N , for a truncated n-body expansion the computational effort will only scale as N n . Thus, if the eb-MBE can be truncated already at the two-body level (resulting in an overall scaling as N 2 ) without substantial loss in accuracy, huge computational savings are possible. In addition, for the MBE the underlying single-point calculations are massively parallelizable, as all fragment calculations are independent from each other.