Overall, three distinct and well-resolved regions (o-ArH, CH3, and N-H) were identified for possible e.e. monitoring with 22-P (Figure , S5). The correlation between the signals of interest was investigated by 2D NMR techniques with enantiopure 10CSA(R) (20 eq.) and their corresponding locations are illustrated in Figure . The gradual addition of 10CSA(R) to 22-P and the influence of water on ∆σmax as a competitive agent is detailed in the SI (Figure -S9). While the ∆σmax values of o-ArH and CH3 are comparable to known pro-CSAs being 0.190 ppm (o-ArH yellow), 0.159 ppm (o-ArH red/green), 0.158 ppm (CH3 red/green), and 0.075 ppm (CH3 yellow), the ∆σmax values of the inner system (N-H red/green) was found to be more than threefold greater than those of other regions (0.653 ppm).