Following the virtual screening of the thirty-nine bioactive compounds established from the phenolic constituent of Vaccinium vitis-idaea L, twenty-five compounds showed higher binding affinity in the active site of PDE6D when compared with the control, Sotorasib (Table ). Further, four compounds with high binding affinity and which conformed to the Lipinski rule of five Targeting PDE6D for inhibiting KRAS: A computational approach standard were identified (Table ). From this study, Rutin had the highest binding affinity of -9.2 Kcal/mol; however, it was not considered for further analysis due to a violation of Lipinski rule of five convention. Among the compounds which conformed to the Lipinski convention, (+) -Catechin (Cianidanol), Arbutin, Resveratrol, and Sinapic acid were identified as potential drug candidate because they can be considered druggable. Therefore, it can be inferred that they are the best bioactive compounds of Vaccinium vitis-idaea L in the active site of PDE6D when compared to the control Sotorasib (Table ). Also, it can be inferred that the selected compounds can bind better to PDE6D and interact with the amino residues, including, Ile129, Iles109, Arg61, Trp90, Gln78 of the target receptor (Fig ). To better ascertain the structural stability of the selected compounds due to lack of accuracy in molecular docking, MMGBSA calculation was adopted to determine the net receptor-ligand interaction. From this study, (+) -Catechin (Cianidanol) had the highest value (-55.8 Kcal/mol) following MMGBSA calculation, which highlight its stronger binding energy to 4JV8 compared to other compounds of Vaccinium vitis-idaea L (Table ). Targeting PDE6D for inhibiting KRAS: A computational approach this study (Table ), (+) -Catechin, Arbutin, Resveratrol, and Sinapic can be pursued as potential drug candidates (Table ).