As in our previous work, herein the term metal complex refers to the d-block elements and the lanthanides, as well as the post-transition metals gallium, indium, tin, thallium, lead and bismuth. Actinides, the d-elements beyond atomic number 100, and the radioactive elements technetium and promethium are excluded. As of June 2020, a total of 1039 metal-containing compounds had been received and tested by CO-ADD. These compounds were submitted by 50 different research groups from 17 countries (and cover 32 of the 49 possible metal elements (Figure ). The overall elemental distribution of the compounds has not changed significantly since our 2020 report. The most represented element is copper, with 187 compounds submitted to date. Compounds were submitted to CO-ADD as dry powders, confirmed to be at >95% purity by the collaborators, and then tested as received. Characterizations of the complexes were carried out by the submitting research group. No quality control check of purity was performed by CO-ADD due to the volume of compounds received, false positives are therefore possible and promising compounds should be checked thoroughly before further development. The procedure reported in our previous study for antimicrobial testing by CO-ADD has been followed. Of the 1039 tested metal compounds, 320 (30.8%) showed activity against a bacterial or fungal strain (MIC ≤ 32 µg/mL). 263 (25.3%) compounds had at least one MIC value that is less than or equal to 16 µg/mL or 10 µM. Of these, 108 (10.4%) complexes showed no cytotoxicity against HEK293 (human embryonic kidney) mammalian cells or haemolysis against human red blood cells. Non-toxic compounds were defined as compounds with HEK293 CC50 >32 μg/mL or >20 μM and haemolytic HC10 >32 μg/mL or >20 μM (HC10 is the concentration causing 10% haemolysis).