In Figure , we show the structures of the macrocycles 1 and 2 and of the ligand ODR of the first bromodomain of human BRD4. The structures of 1 and 2 were obtained from Cambridge Crystallographic Data Centre, CCDC 2051483 and CCDC 1950443. The phenyl [5]-cage 1 is characterized by two rapidly exchanging structures due to the flipping of the three phenyl sidewalls. The two conformation can be distinguished in NMR experiments when 1 selectively binds to quarternary ammonium ions via an induced fit mechanism. Compound 2 (amide naphtotube)