The cornea is the transparent outermost layer of the eye and its primary functions are to serve as both a physical barrier for the interior of the eye and contribute to the refraction and focusing of light onto the lens and retina. The cornea comprises five distinct layers: the epithelium, Bowman's layer, stroma, Descemet's membrane, and endothelium. The structural integrity and the intricate cellular communication within and between these layers are critical for maintaining the transparency and functionality of the corneal tissue. Corneal injury may arise from chemical or thermal burns, mechanical trauma, infections, or underlying pathological conditions. Minor corneal abrasions can typically heal by itself within a couple of days. On the contrary, in the event of more severe injuries, such as corneal lacerations and perforations, the cornea´s transparency may be compromised which can lead to corneal blindness. Corneal perforation is an emergent condition requiring prompt treatment to seal the eye and restore the eye's anatomy. The treatments range from corneal gluing to corneal transplantation by donor corneas. For small perforations (up to ~2-3mm), gluing is the most common treatment and there are two major variants; cyanoacrylate tissue adhesive (CTA, non-biologic) and fibrin glue (biologic). CTA is the stronger one of the two but the drawbacks include tissue toxicity due to unreacted monomer and release of formaldehyde due to degradation, rapid polymerization leading to a very short time window for application during surgery, highly exothermic reaction, non-biodegradability, foreign-body reactions, and inconsistent adhesion on wet surfaces. Further, CTA often induces neovascularization which also can lead to corneal blindness. Fibrin glue on the other hand is nontoxic and completely biodegradable. However, as it originates from donor blood, there is a risk of transmitting viral or prion diseases. It has also been shown that fibrin glue inhibits corneal epithelialization, delaying the healing process. An adhesive possessing the biocompatibility of fibrin glue without impeding epithelialization would therefore be highly advantageous. In the event of larger perforations (>2-3mm), keratoplasty becomes necessary. However, due to donor shortages, a considerable number of patients are unable to access this treatment emphasizing the crucial need for innovative methods.