The reaction was then quenched with 1 mL deionized water, agitated vigorously, and then allowed to stir at room temperature for 15 minutes. The vial's contents were then transferred to a separatory flask and diluted with 10 mL DCM and 10 mL 1% aqueous HCl. The organic layer was separated and the aqueous layer was extracted with a second portion of DCM. The combined organic layers were then washed sequentially with equal volumes of 1% aqueous HCl, saturated sodium bicarbonate solution, and brine. The resultant organic layer was dried with MgSO4, filtered and concentrated in vacuo. The mixture was concentrated then suspended in 1-2 mL of ethyl acetate to provide a suspension. The suspension was filtered and washed with ethyl acetate then dried to yield 1 as a white powder (0.059 g, 0.17 mmol, 38%) as a white solid. General Procedure B for Amide Coupling (shown for 14).