In Vitro Dissolution of AMF-exposed tablets. Fasted state simulated intestinal fluid (FaSSIF) was used as a biorelevant medium to study the in vitro dissolution and was prepared according to the manufacturer's instructions (Biorelevant.com). The mixture was equilibrated for 2 hours before use and used within 48 hours of preparation. Amorphous celecoxib and conventional ASD (30 wt% drug load) were prepared by melt quenching technique. The drug polymer ratio for the conventional ASD was selected based on the tablet resulting in maximum amorphous content induced by in situ amorphization (tablet 26, Table ). For the ASD, the drug and polymer were weighed and mixed thoroughly using mortar and pestle. This mixture was spread in a thin layer on a sheet of aluminum foil and placed in an oven at 169 °C for 5 min, after which, it was removed, cooled to room temperature, and then pulverized using mortar and pestle. This process was repeated twice for the ASD and once for amorphous celecoxib.