For a better understanding of the contributions of individual non-covalent interactions to the ∆∆Eint, we have applied Espinosa's equation ("equation( )") to quantify the strength of hydrogen bonds in the hydrogen-bond network. The equation implies the correlation of the hydrogen bond energy (EHB) to the pressure exerted on the electrons around the critical point (V(rcp)), both related to the strength of the hydrogen bonding (HB) interaction.