Mesoscopic molecular simulation methods bridge the gap between atomistic simulations and macroscopic continuum models by grouping atoms into computationally manageable units known as coarse-grained beads. By reducing the number of degrees of freedom, coarse-graining enables the simulation of larger systems over longer timescales compared to fully atomistic models. The primary distinction between different mesoscopic models lies in their descriptions of interactions between coarse-grained beads (Figure ), leading to variations in both accuracy and computational efficiency.