The overall project simulation is thus controlled by three main parameters -numbers of active and kill bits, and the sampling rate -as well as the number of set bits and the bit-string length. The number of set bits and bit-string length for real projects can be derived from analysis of their Morgan fingerprints. The number of bits set in the simulation bit-string can be directly related to the median number of bits set in a real project -for the set of Syngenta herbicide projects this was 61 bits in a 256-bit Morgan fingerprint (ECFP6, Pipeline Pilot).