Synthesis of silver nanoparticles using plant extract is an extremely cost-effective method of synthesis and hence can be a valuable alternative for large scale production of AgNPs . In this, the plant extract is used as reducing agent and stabilizing agent for the synthesis of AgNPs which rules out toxicity caused by conventional chemicals used to synthesis AgNPs . Due to their nonpathogenic characteristics and biocompatibility, AgNPs synthesized by plant extract are ideal for biomedical applications . The plant extract consists of phenolic compounds such as alkaloids and flavonoids which provide the reagent with unique reducing and capping properties, these compounds are also soluble in water . Plants naturally detoxify the ground water by removing impurities such as heavy metals . Redox potential is one of the most significant factors in the detoxifying process , this can be used to utilize plants for reduction of metal cations (Ag + ) and synthesize AgNPs. This process may be considered as in vivo and in vitro synthesis process . The in vivo synthesis can be defined as the synthesis of AgNPs inside the plant on the other hand in vitro synthesis can be defined as the synthesis of AgNPs by the plant extract Torresday et al.