BTA-derived ~ 1000 top-children (Figure , red) were finally selected to ADV target the bottom-site mutations with highly restricted grids (13x13x13 Å) centered at the drug-site mutations. Results were tabulated to compare X-axis with top-children affinities versus one mutation per Y-axis column (Supporting Materials / 979BTAmutations.dwar). Top-children predicting affinities < 50 nM to most resistant mutations, identified compact star-like molecules with 3 short arms extending from a central carbon (Figure , red circle) containing 6-8 ring structures in 2 slightly different scaffolds (Figure ). Further DWBEL may be required to explore for possible F140I and F488I higher docking affinities using the new DWvs6 (java's BellSoft Liberica), which included more efficient handling of larger heap-memories compared to DWvs5 (java's 8) (Figure ). Nevertheless, since some amino acid substitutions to those mutations reduced RSV replicative fitness during co-infections with wildtype RSV , such RSV variants may also have difficulties to spread into a natural infection 30 .