The synthesis of the trithiolato diruthenium complexes is generally straightforward and efficient , and this scaffold is robust to chemical modification and easily adaptable to the conjugate strategy as demonstrated by the various series of hybrids with peptides , drugs , fluorophores , or metabolites . Ester and amide couplings , but also CuAAC (Cu(I)catalyzed azide-alkyne cycloaddition) click reactions , proved to be useful tools for the functionalization of the diruthenium trithiolato unit at the level of the bridge thiols. CuAAC offer the advantage of mild reaction conditions, compatible with various ligands but also with organometallics , and enables the construction of libraries of compounds 95, [107-109]. For example, this type of modification allowed the obtainment of RAPTA-type ruthenium(II)-arene anticancer compounds , but also the synthesis of various ligands used to generate carbohydratefunctionalized 1,2,3-triazolylidene ruthenium(II)-arene catalysts . Likewise, various platinum, ruthenium and ferrocene glycoconjugates for bio-applications were obtained using click reactions . Additionally, trithiolato diruthenium(II)-arene compounds suitably substituted with alkyne or azide groups were already used in CuAAC reactions for obtaining conjugates with molecules of interest e.g., various nucleic bases or drugs . .