The analysis of the RDGYR raises an immediate question: whether some conformer generators tend to correctly produce more compact or extended structures. To answer this question, a correlation analysis was performed between the RMSDmin and RDGYR values of the experimental Moltiverse and CONFORGEsys-def achieved the overall smallest |ρ| (Table ), 0.26 and 0.34, respectively, suggesting that both algorithms can generate both compact and extended structures with similar accuracy.