In March 2024, Pybus, L., et al. developed SymphonX TM to address the growing demand for integrated and continuous biomanufacturing (ICB). The modular and multi-functional purification downstream processing method with advanced buffer management is designed to be plug-and-play with cGMP facilities, utilizing a mAb-expressing cell line, and single-column chromatography to reach continuously pooling product for 6 days . Paper 06: 58 words, Time: 6 minutes 30.89 seconds In March 2024, Liang, G., et al. studied the effects that process intensification of continuous monoclonal antibody has on homogeneity. In specific, the authors wanted to determined whether product quality attributes (PQA) would be affected at different cell densities. Glycosylation of IgG1-κ mAb was increased in G0F and fucosylated type glycans, with sialyted type glycans numbers being decreased. The authors' conclusion was that increasing process intensification may impact PQA which may require assessment . Paper 07: 73 words, Time: 8 minutes 7.55 seconds In 2024, Konoike, F., et al. developed a continuous downstream process of mAbs using periodic-counter current chromatography (PCCC) with two protein A columns. A batch reactor was used for low pH virus inactivation, with flow-through chromatography (FTC) using anion-mixed mode and cationexchange for the polishing step. Six different run feed rates and feed concentrations were performed, with the largest feed rate at 10 L/day with a 2 g/L concentration in a GMP facility yielding "good recovery and purity values" for all runs . Paper 08: 88 words, Time: 6 minutes 3.