The crystallization results are summarized in Fig. and Supplementary Table -S9. We used the abbreviations CA•1 to CA•20 to denote the cocrystals formed between CA and 20 different molecules selected in this work. Of the 20 combinations screened in 20 commonly used organic solvents, three combinations, three combinations (CA•3, CA•18, and CA•19) failed to yield cocrystals, due to limited solubility of components 3, 18, and 19 in the selected solvents. The remaining 17 combinations successfully formed cocrystals, with polar solvents performing better than non-polar solvents (such as alkanes and xylenes) in promoting hydrogen-bonded cocrystal formation. This enhanced performance can be attributed to the decreased solubility of CA in low-polarity solvents. As solvent polarity decreases, CA solubility further diminishes, resulting in a greater disparity between the solubilities of the two components. These findings highlight the critical role of solvent polarity in facilitating cocrystal formation, where polar solvents favour cocrystallisation over the separate crystallisation of individual components. Additionally, they underscore the challenge of achieving cocrystallisation when there are significant differences in the solubility profiles of the components.