The surface engineering of nanomaterials benefits targetselective delivery by engineering the "nano-bio interface" where will be the contact point between a nanomaterial and target . Classically, targets, such as a specific cell surface or cytosol, are considerably larger (>1 μm) than nanomaterials (several tens of nm). Under such conditions, the dominant property of the nano-bio interface is determined by the entire properties of the nanomaterial surface, including its total surface charge, hydrophilicity/hydrophobicity, and/or total radius. Conversely, if the target is as small as the nanomaterial, the detailed surface shape, e.g., the numbers of convexes/concaves or radius of the material surface, cannot be neglected . Therefore, imparting skillfully developed characteristics is key to designing manipulators for small structures.