However, no matter how much effort is put into parameterizing small molecules against experimental data, the assumption of transferability remains. That is, the assumption that parameters that are optimal for small organic molecules are also suitable for larger molecules, such as drug-like compounds or even biomolecules. It is well-established that charges polarize in response to their environment, for example the presence of electron donating or withdrawing groups. Indeed, users of transferable FFs typically derive system-specific charges to account for this polarization, either from semi-empirical or QM calculations. Moreover, it is becoming increasingly apparent that van der Waals parameters themselves show interesting environment-dependent responses. Accounting for changes in van der Waals parameters with changes in FF charges, or the atomic environment, is beyond the scope of most transferable FF protocols.