Figure and Table illustrate that for urine, 12 out of 90 analytes (13%) displayed a higher sensitivity in HRMS than in LRMS. This value is 29 (32%) for serum and 22 (24%) for plasma. Moreover, the plots in Figure show that the majority of the polyphenol classes have similar average LODs between the two instruments. The median of the LODs of urine, serum, and plasma in the HRMS instrument were 18, 10, and 11 ng/mL, respectively, compared to 4.8, 5.8, and 5.2 ng/mL, respectively, in LRMS. However, the box plots of Figure show that HRMS has a larger variance between the different analytes in each polyphenol class than LRMS.