These results affirm our previous conclusion, based on S66 data, that DLPNO errors obtained at the RI-MP2 level are likely lower bounds to those obtained at the CCSD(T) level, probably due to the approximate treatment of the weak pairs in DLPNO-CCSD(T). To obtain benchmark-quality CCSD(T) interaction energies whose fidelity approaches 1 kcal/mol with respect to canonical results, PNO thresholds more conservative than tight-CCSD(T) (i.e., T CutPNO = 10 -7 ) may be needed in large supramolecular complexes. For reasons of cost, however the loose/normal/tight hierarchy for T CutPNO is set in the opposite sense, i.e., the cutoffs are more aggressive at the DLPNO-CCSD(T) level than they are for DLPNO-MP2. This may not be appropriate for large van der Waals complexes.