To conclude, it is demonstrated that enantiomeric recognition can be initiated by the intrinsic OAM polarization in the B20 family chiral compounds. This was experimentally confirmed by the different oxidation kinetics of DOPA enantiomers at the surface of PdGa (111) single crystals. Adsorption and bonds formed between the DOPA enantiomers and the chiral crystals are strongly dependent on the compatibility of the OAM with each other. Our study highlights the importance of OAM polarization as a promising driven force for enantiomeric recognition. It is hoped that this work will stimulate further studies of other solid states crystals (minerals), where more significant and pronounced enantiomeric recognition, enantiomer separation, and asymmetric catalysis reactions can happen.