The most recent successful inhibitory activity of the computationally guided abaucin 1 , the availability of crystallized E.coli LolCDE models , the accuracy improvements in modeling proteins by alphafold , and the application of recent DW build evolutionary library predictive algorithms , have been combined here to computationally extend hypothetical new abaucin-derived chemotypes predicting nanomolar affinities for future antibiotic candidates against A. baumannii.