The small differences between ∆ el E el,W ⊕C (z) and ∆ el E vw⊕el,W ⊕C (z) (and similarly for the entropic terms) shows that there is little change in the LJ energies between DS -and the solvent as a result of turning on the partial charges. Additionally, at the ACWI, the orientational distributions of DS -and DS 0 are similar, leading to similar LJ interactions.