General procedure for the synthesis of isoxazolines 10. NaHCO3 (252 mg, 3.00 mmol) was added to a solution of sultam 1 (1.00 mmol) and chloroxime 7 (1.50 mmol) in EtOAc (10 mL) in one portion, and the resulting solution was stirred at rt for 24 h. Then the reaction mixture was filtered through a plug of silica gel, washed with EtOAc (20 mL), and concentrated in vacuo. The residue was subjected to the reverse-phase HPLC purification using deionized H2O -MeCN system (gradient 1/0 to 0/1) as eluent.