From the above facts and elaboration, a very important principle can be observed, valid in the genetic code, which could not be observed without a semiotic approach: with as few of the same quantities as possible (signifiers) to be designated as many different qualities as possible (signified). The next point is another important reference to De Saussure. The arbitrariness of signifiers has limitations (Box 3). We see this primarily in that, in all important cases, chemical distinctions are accompanied by changes in quantities for the unit of the first, second, and third order; for the unit in two or three positions of the quantity records. 11 We find such a situation in Tables 1-8 and other illustrations in this as well as in my previous works.