hypotheses regarding implications of particular amino acid substitutions on overall receptor affinity must be confirmed/refuted by means of appropriate information on relevant noncovalent binding factors, and that (b) in the absence of such information, classical molecular dynamics simulations, as well as insights drawn from "chemical intuition", are prone to lead to erroneous conclusions. Alas, claims according to which 2019-nCoV has, in fact, a higher affinity towards ACE2 compared to SARS-CoV should not be based upon shots in the dark and questionable expectations.