To probe the utilization of this approach, we performed the antifungal activity tests of four gem-difluoroalkene coumpounds (4ar, 4pd, 4qd, and 4rd) aginst five phytopathogenic fungi including Sclerotinia sclerotiorum (SS), Thanatephorus cucumeris (TC), Colletotrichum acutatum (CA), Colletotrichum viniferum (CV), Fusarium equiseti (FE). As shown in Figure , no obvious inhibitory activities towards all five phytopathogenic fungi were obtained for compound 4pd and 4rd, whereas compounds 4ar and 4qd exhibited reasonable antifungal activity towards SS with inhibitory rates of 14.3% and 19.4%, respectively. Notwithstanding, further rational design and decoration of the gem-difluoroalkene derivatives are still warranted to improve their antifungal activities. In summary, we have demonstrated a visible-light-photocatalyzed gem-difluoroallylation of both acyclic and cyclic ketone-based dihydroquinazolinones with α-trifluoromethyl alkenes via discrete C-C and C-F bond cleavage. This method is distinguished by its mild reaction conditions and broad substrate scope. We believe this method could complement existing approaches to gem-difluoroalkene motifs by masking gem-difluoroallyl functionalities with a carbonyl group in ketones. Further investigations of mechanism and antifungal applications are still underway in our laboratories.