Industrial exploration of secondary metabolites requires thorough understanding of regulatory genes, biosynthetic enzymes, and genetic foundations. This knowledge forms the basis for metabolic engineering tactics that maximize the production of desired natural products while maintaining financial sustainability. Moreover, these biosynthetic enzymes are essential to many biotechnological activities. Nielsen et al. presented an excellent work on the worldwide investigation of clusters of biosynthetic genes in Penicillium species. Interestingly, study of 24