In addition to reagent identity, our text mining method provides information about the quantity of each reagent used, enabling analysis of synthesis protocol scale and reaction stoichiometry (Figure ). The scale of ZIF-8 synthesis follows approximately a log-normal distribution, with 95% of synthesis using 0.18-46 millimoles of metal ions and 0.73-330 millimoles of 2-methylimidazole (Figure and B, respectively), demonstrating the flexibility of ZIF-8 synthesis with respect to scale. In terms of reaction stoichiometry, most synthesis protocols use an excess of linkers compared to the stoichiometric ratio of 2:1 (Figure ). This excess has been shown to control particle sizes by slowing the rate of crystal growth, although few synthesis protocols use a higher ratio than 8:1. Interestingly, despite clear evidence that excess concentration of metal ions forms undesired byproducts such as Zn(OH)(NO3)(H2O), 6% of the synthesis protocols analysed used a molar ratio of 1:1 or lower. After considering reagents, the next most import aspect of a synthesis protocol lies in the choice of solvent environment for the reaction. Solvent choice has ramifications on the reaction mixture dielectric constant, in turn dictating factors such as reagent solubility and reaction kinetics. Further, the choice between protic and aprotic solvents, can accelerate reaction mechanisms relying on proton transfer, such as the linker deprotonation present during ZIF-8 synthesis. Finally, overall reaction concentration is critical for determining whether the reaction mixture will act as an ideal solution, and in terms of the relative mass efficiency of the synthesis, both of which have consequences in terms of synthesis protocol viability in terms of scaleup to process-level manufacture.