Aptamers have been used in diabetes detection before. For example, Lee et al. developed ssDNA-based aptamers that bind to the retinol-binding protein for the early detection of diabetes . These aptamers were attached to a gold chip, and SPR was used to detect the aptamerprotein specificity. They have also stated that these aptamers are more sensitive than ELISA assay . In a different study, Apiwat et al. have developed graphene-based aptasensor diagnosing diabetes mellitus . Moreover, aptamer has been used to identify SecinH3 in human liver cells . Apart from diabetes mellitus, aptamer has been used in various metabolic diseases such as aptamer targeting adipose tissues could have an impact on obesity and metabolic syndrome . Till now, aptamer targeting is as follows: HbA1c, GHSA, RBP4, adipocyte cell line, and visceral adipose tissue-derived serpin . Noninvasive aptamermediated therapy targeting pancreatic B cells will be a valuable tool and pave the way for treating diabetes and its complications. We hope future research will focus on the aptamer-mediated inhibitory effect of T cells and macrophages in diabetes complications .