The simple d-centrality does not follow a clear trend regarding the correlation between residue position and assigned centrality value. The band e-centrality approaches assign low centrality values to surface residues, which matches the expected behavior since the corresponding nodes rarely appear in paths along the graph and are not able to form connections to other high-scoring nodes. Overall, the centrality value distribution for b-centrality reasonably matches the distance distribution, which still is an important measure in QM region construction. This indicates that betweenness is the most sensible approach to be used in the following.