Studies have found increased frequencies of autoimmune diseases over recent decades. 1, 2 The number of research reports focused on autoimmune diseases have grown correspondingly. According to the CAS Content Collection 3 over 150,000 research documents related to autoimmune diseases have been published since the year 2000, with over 35% growth in the last three years (2021-2023) as compared to 2019 (Figure ). Advancements in identifying biomarkers and using genetic analysis are leading to earlier and more precise diagnoses, which is crucial for developing targeted therapies 5 ; (iii) More people getting autoimmune diseases: Data suggests a significant increase in the prevalence of autoimmune diseases. The concept of "inverse vaccine" is a relatively new and not a well-established concept yet, so the number of related documents identified in the CAS Content Collection is relatively low, but steadily growing (Figure ).