Mangiferin was subjected to methylation, a solution of mangiferin in acetone was reacted with dimethyl sulfate (DMS) and K 2 CO 3 with continuous stirring at room temperature for one week. The resulting reaction mixture was kept for evaporation, which gave a residue that was fractionized with the solvent-solvent separation technique using the ratio of solvents, chloroform:methanol (8:2). The combined residue was collected and concentrated to result in desired compound 3.