Chalcones provide a variety of therapeutic benefits, such as antiplasmodial action . They are essentially secondary metabolites found in plants that belong to the flavonoid family and serve as important building blocks for both individual flavonoids and isoflavonoids. Due to their many pharmacological effects, particularly their anti-malarial efficacy, they have undergone substantial research. Chalcones may also be easily created using the economical Claisen-Schmidt condensation of acetophenones with variably substituted benzaldehydes, yielding a variety of unique potential analogues with strong pharmacological properties .