A limited number of simulation strategies have been developed to avoid the effects of solute depletion that shift the thermodynamic driving force for steady-state crystallisation in simulations. The constant chemical potential MD method (C𝜇MD) ] employs a closed system that is segregated into a transition region (TR), housing the process of interest; a control region (CR), representing a bulk fluid with fixed composition; and an internal reservoir that supplies the CR with solute monomers as they are removed from the liquid phase toward the growing crystal in the TR. In doing so, steady-state crystal growth is maintained for relatively long simulation times, as was shown in the case of, e.g., urea, isoniazid and naphthalene, which demonstrate crystal facet and solvent dependent growth rates. In addition, crystal nucleation can be studied using a spherical variant of C𝜇MD that was applied to simulate NaCl crystallisation. Combining multiple, carefully prepared closed system simulations (representing steps on a nucleation reaction coordinate) to maintain the solution concentration as solute molecules are transferred to a crystal nucleus, out-of- equilibrium sampling in the so-called Osmotic ensemble can be performed to avoid solute depletion effects. .