Compound selection was performed completely independently and blind of player identity. However, six of the selected compounds came from an experienced medicinal chemist on the evaluation team (C.A.P.S.), who had played the puzzles in his free time, but none of these compounds showed any binding. The compound that showed binding was based on a round 6 design from player 'Nicm25', who joined Foldit in early 2020, and who has no formal medicinal chemistry experience (personal communication).