(a) eliminate potenVal solvents that were not liquids at, or near, room temperature (melVng point ≤ 40 °C), and that have a high boiling point (boiling point ≥ 90 °C), to ensure the selected solvents were liquids at reasonable temperatures and were comparable to previously reported PL solvents to avoid significant evaporaVon during experiments. These temperatures were selected so the soluVons/mixtures could form liquids at room temperature (20 °C, assuming some melVng point suppression could occur) and so solvent evaporaVon would not significantly affect the prepared samples when under experimental invesVgaVon. (b) eliminate solvents with funcVonality that could potenVally react with the POC imines, such as amines and thiols, alongside any with significant hazards, including those fatal upon any exposure route, carcinogens, mutagens, or teratogens. (c) finally, cost was considered, and any solvents that were not commercially available at <£3/g were removed. Applying these criteria led to 10 solvents with an Ra below 9.7 MPa ½ that were taken forward for experimental validaVon of the solubility predicVons and subsequent size-exclusivity screening (Figure ).