To extend our systematic comparison of scoring, we introduced quality thresholds. PDPS was set at 70% as used for P&D approved probes. For CPOC and CPOO, we raised this to 75% (equivalent to 3 out of 4 stars in the original rating system). For the PMIS, there is no clear threshold and since the highest value is 85%, a setting of 75% would leave only 54 compounds from more than 3,000. We thus chose to set the Probe Miner threshold at 60%, thus leaving 1,282 compounds, a similar number to P&D approved probes.