We invite our colleagues to use SCSD terms in multistructural analysis and reviewthis is a structural comparison technique which can yield genuine insight into chemical properties and the efficacy of strategies toward dissymmetry. Given that often individual crystallography papers can offer only limited context for their reported structures, a numerical basis allows one to formalize these insights succinctly and with statistical power. We hope that this conformational control, in concert with chemical modification, can elicit new modes of reactivity and tuning of the innate properties of organic and coordination compounds.