 The HGNC entry for the approved human gene symbol PIR with pointers to eight orthologues supported by the Vertebrate Gene Nomenclature Committee (VGNC)  Gene Ontology (GO) assignments for metal ion binding, quercetin 2,3-dioxygenase activity and transcription coregulator  11 PDB entries  A target link to CHEMBL2010627  The Open Targets link (a meta-portal including genetics, disease association and expression evidence)  Evolutionary history in Ensembl GeneTree  Human Protein Atlas (HPA) antibody and transcript tissue distribution  The InterPro domain mark-up (shown in Fig. ) The CHEMBL2010627 points to a key publication ('Discovery of a Chemical Probe Bisamide (CCT251236): An Orally Bioavailable Efficacious Pirin Ligand from a Heat Shock Transcription Factor 1 (HSF1) Phenotypic Screen . The probe structure is PubChem CID 117996749. Note that this paper was also cited as reference 28 in Doi/10.1021/acsptsci.8b00048 and the similarity between this and the Neubig series was noted. From PubChem > SureChEMBL we find example 63 from WO2015049535 ('Fused 1,4-dihydrodioxin derivatives as inhibitors of heat shock transcription factor 1' assigned to Cancer Research Technology Ltd. UK.). Notwithstanding, this chemical probe also has passed initial development criteria in being orally bioavailable and displaying efficacy in a human ovarian carcinoma xenograft model.