To gain further insights into the binding modes of the confirmed ML-nominated hits, we cocrystallized the WDR domain of WDR91 (residues 392-747) in complex with compounds 2 and 4, referred to here as WDR91_2 and WDR91_4, and refined the co-structures to 2.3 Å and 2.1 Å resolutions, respectively. Table summarizes the crystallographic data collection, refinement and validation statistics.