The extent of interaction between the protein and polymer affects the diffusion behavior of the protein-polymer conjugate. For the dumbbell model, minimal interaction allows the protein and polymer to behave as independent molecules, and we would predict that the diffusion behavior of such a system would be nearly identical to the unconjugated protein. In contrast, for the shroud model, more extensive proteinpolymer interactions would decrease the rate of diffusion of the system relative to the unconjugated protein.