PTX is a commonly applied chemotherapeutic agent in the treatment of various cancers, such as lung, ovarian, and breast cancers. is a natural yellow orange dye derived from Curcuma longa. Because it reportedly has a plethora of biological effects such as affecting the expression of inflammatory cytokines, adhesion molecules, enzymes, of transcription factors and their signalling pathways et al., CUR is considered by many as a potential treatment in cancer, atherosclerosis, neurodegenerative disease, hepatic disorders, diabetes, psoriasis, autoimmune diseases and so on. However, its chemical instability in aqueous media also prompted a very critical discussion, labelling it as a pan assay interference compound (PAIN) or invalid metabolic panacea (IMP). While we acknowledge the importance of these issues, we also think that specifically these issues make CUR an interesting model compound for formulation studies.