Plants produce a broad and diverse variety of organic compounds, most of which do not directly participate in their growth and development. Traditionally, these compounds are referred to as secondary metabolites or natural products (NPs) and often exhibit differential distribution among limited taxonomic groups within the plant kingdom. NPs are distinguished by the complexity of their chemical structures and biosynthetic pathways. Organic chemists have long been interested in these substances, extensively investigating their chemical properties since the 1850s. NPs have been the focus of attention of the scientific community in recent decades, and their interest is growing. These molecules present remarkable chemical diversity and have been extensively studied for numerous applications, including drug discovery (with a notable focus on anticancer activity among other promising therapeutic areas), food science, agriculture, and the cosmetic industry. Plant-based compounds stand out among all-natural sources due to their rich and unique chemodiversity and structural complexity. Latin America has high plant biodiversity, primarily found in the Amazon rainforest, the Andean Mountains, and the Central American tropical and subtropical forests. In particular, Colombia's biodiversity accounts for more than 28,900 reported plant species, of which about 26% are known to have reported human uses and socio-economic importance. These plants are found in all bioregions and ecosystems of Colombia, due to the topographic and climatic diversity that has contributed to the formation of a wide range of habitats. Despite the country's abundant natural resources, scientific knowledge of Colombian flora still lags behind in several aspects. Therefore, in recent years, Colombian authorities have focused on the importance of the country's biodiversity and have initiated the development of governmental programs to maximize the potential to use it. Colombia is divided into six natural regions: the Amazonian, Andean, Caribbean, Orinoquia, Pacific, and Insular areas (Figure ). This classification delineates natural regional boundaries based on topography, ecosystems, vegetation, and watersheds criteria. The botanical genera with the highest species richness in Colombia include Inga, Passiflora, Miconia, Solanum, Pouteria, Protium, Annona, and Bactris. 11 Among these species, there is remarkable utilization, with various species serving different subsistence needs and medicinal plants being used to treat serious diseases such as malaria, leishmaniasis, snakebites, and other common ailments. The colombian Andean region, which includes the Coffee region, is known to be one of the most species-rich areas for plants. 14 The Coffee region, also known as the "Coffee Triangle," is a geographic region in Colombia renowned for its high-quality coffee production. This area is located in the heart of the Colombian Andes and includes the departments (similar to states in other countries) of Caldas, Quindío, Risaralda and northwest of Tolima. It borders with other departments, Antioquia to the north, Tolima to the east, Valle del Cauca to the south, and Chocó to the west. The region is characterized by its mountainous topography and volcanic soils, which provide ideal conditions for coffee cultivation. Altitudes in this area range from 1,200 to 2,000 meters above sea level, resulting in a large diversity of microclimates. The availability of scientific information about plants in the Coffee region primarily focuses on assessing biological diversity. This is evident when conducting a literature search using keywords such as "plants" and "Colombia." However, as discussed later, information on NPs derived from plants is fragmented, less accessible and scarce.