Moreover, it explains the expression, biology as well as its effect on renin-angiotensin system as well as kinin-kallikrein system which might help in developing coronavirus therapies . Moreover, it is known that SARS Cov-2 uses its spike S protein in order to infect the lung cells. This happens by binding to its ACE2 receptor which is present in its transmembrane region. SARS Cov-2 causes multi-organ damages by entering via the respiratory tract and targets the epithelial cells of lungs and then spreads to the other organs as well via hematogenous growth or blood stream. Viral E proteins disrupt the inner epithelial barrier by interacting with the cell junction associated proteins which include ZO-1 and PALS1 which help in further massive penetration. ACE2 receptor is majorly distributed in tissues including those of lungs, kidneys and P a g e 11 | 56 intestines due to which it is considered to be the primary virion loading site. Other than ACE2, NRP1 also mediates the endocytosis of virus in the brain region. Interaction of PDZ requires the entire viral loading process. Proteins including E, NRP1 and ACE2 provide the PDZ binding motif which is needed for the connection with other proteins including PALS1 NHERF1 and ZO-1 and Beta arrestins which might disrupt the GPCR signalosomes assembly that might lead to loss of smell and taste. Therefore, it could be inferred from the study that disrupting these interactions might reduce the coronavirus entry. Moreover, these GPCR targeted drugs might also reduce the symptoms of Coronavirus . SARS-CoV-2's spike glycoprotein binds to the ACE-2 receptor and causes its downregulation which further leads to the RAS dysregulation.