As previously mentioned, 11β,13-dihydrolactucin (dihydrolactucin, DHLc) is an important STL found in chicory root. In this study, DHLc was used as the main substrate to test the acylation reactions due to its strong structure similarity to lactucin and the other STLs. For information purposes, chicory STLs remain largely commercially unavailable as they can only be found in very small quantities and at very high cost as reference standards (+/-400 $/10 mg from ExtraSynthese.com). It is therefore challenging to obtain them in the quantities required to explore novel synthetic routes. DHLc used in this study was in fact extracted in-house from lyophilized chicory root and purified via flash-column chromatography. The complete extraction protocol was set up especially for this occasion and is described by Ruggieri et al. (2023). NMR analysis was used to validate that the structure was identical to the analytical standard.