We were able to liberate trisodium tris(3-sulfophenyl)phosphine (TPPTS) from 1 upon addition of highly nucleophilic thiols such as N-acetyl-cysteamine 4 (Figure ). To ultimately achieve thiol amplification, we further evaluated disulfide reduction by liberated TPPTS using N,N'-diacetylcystamine 3. Using optimized conditions, sub-stoichiometric amounts of 4 are able to initiate the system, resulting in the formation of by-product 2 and the release of TPPTS.