The CVHD method 32 is a CV-based algorithm that combines metadynamics with aspects from hyperdynamics by using a history-dependent bias constructed from a sum of repulsive Gaussians. The changes in CV values reect how far the system has traveled away from the reference state and are thus dened as local distortions X i . The local distortions are combined into a global distortion X t using a p-norm to globally describe the distance from the reference states according to