Arynes are valuable reactive intermediates because they engage in a multitude of different reactions, including nucleophilic addition, -bond insertion, cycloaddition, transition metal catalyzed coupling, and rearrangements initiated by these pathways (Scheme 1a). Consequently, arynes have significant potential to derivatize benzenoid cores that are prevalent in active pharmaceutical ingredients (API) and drug candidates. However, despite their potential, arynes have not found the same level of use in synthetic applications as other reactions of arenes. 3 This is, in part, due to a lack of direct and mild reaction that link readily available arene building blocks and aryne intermediates. Therefore, new synthetic methods are needed to uncover ideal aryne precursors.