To sum up, we can conclude that the current work provides a comprehensive analysis of our current knowledge about the chemobiological space of gut microbial metabolites, and in addition openly provides a large set of novel validated predictions that will allow to fill in an efficient way many uncharted regions in this space. All the results of this analysis (published interactions, predicted interactions, target prioritizations) are provided in Table in the Supporting Information. It will be useful to complete our knowledge about the mode of action of these highly important molecules in human health.