In summary, we have investigated the role of the electrolyte and binder on the performance of a redox-active COF (DAAQ-TFP-COF) electrode material. Our results demonstrate that by identifying the most suitable electrolyte (LiTFSI in TEGDME) and binder (TPFE) for DAAQ-TFP-COF, specific capacities close to the theoretical values (88% real utilisation of the active material) were obtained without the need for extensive COF processing (e.g., exfoliation). The most likely reasons for the improved performance are the better stability of prepared COF-based electrodes in non-carbonate electrolytes and the improved ion diffusion through the PTFE binder. Ex situ IR experiments confirmed the reversibility of the electrochemical process in agreement with the galvanostatic cycling performance. In addition, electrochemical tests were performed using symmetric cells by combining two DAAQ-TFP-COF electrodes to identify the contribution of the metal anode in the 2-electrode setup. To further investigate the electrolyte influence on the cycling of COFs, we have employed DAAQ-TFP-COF in Mg cells using non-chlorinated and chlorinated Mg electrolytes We are confident that our results will be very useful in evaluating and comparing the performance of COF-based electrodes in metal-ion batteries as well as stimulating the optimisation of electrolytes and binders for this type of organic batteries. As COFs are interesting host materials for a variety of ions, more efforts should be invested to facilitate the accommodation of multivalent cations, where high performance organic cathode materials are urgently needed.