As above, nitazenes are highly potent synthetic opioids. 17 Whilst nitazenes, are not at present found regularly in e-cigarette liquid, their high risk means detection would be useful. To pre-empt the detection of this very high-risk scenario, we investigated a means for their detection in e-liquid using the EDD. The recency of nitazene presence in the dug supply means the literature regarding nitazene concentration in e-liquid, or indeed oral potency, is absent, and so we have investigated similar concentrations to our SC experiments above. Figure shows the spectrum acquired directly on-filter after artificial actuation of a 1.5 mg/mL etonitazene e-cigarette. The solid black plot shows emission captured at t=0 s, with the three grey plots showing emission after constant irradiation with the 265 nm LED for 10 s, 20 s and 30 s. The main emission band of etonitazene is centered at ~390 nm. This presents challenge to detection in many types of e-liquids as etonitazene emission overlaps significantly with the emission bands of compounds. However, similar to THC above, etonitazene apparently undergoes a photochemical reaction that results in an increased magnitude of emission and a slight red-shit to ~400 nm, most apparent at t = 30 s under the conditions used here.