Palladium on carbon was used to catalyse the reduction of compound 12 in DMF. The solution was filtered through celite to remove the palladium on carbon, followed by removal of DMF in vacuo to afford bis-amine 13 in 94% yield. The synthesis of compounds 1-4 and 6-9 was initially attempted by reacting 12 with an excess of the respective isocyanate or isothiocyanate in a minimum amount of dry DMF and the progress was followed by TLC. Upon completion, the reaction mixture was poured into ice water, resulting in precipitation of the desired product and other side products. Residual DMF was removed with additional washes of deionised water and the side products were removed with washes of various non-polar solvent mixtures (see the experimental section for details). DMSO was found to be a suitable alternative solvent and was used in several the iso(thio)cyanate condensation reactions. 4-(Pentafluorosulfanyl)phenyl isocyanate and isothiocyanate and were prepared from 4-pentafluorosulfanylaniline. The isothiocyanate was formed by reacting the aniline with thiophosgene in a biphasic mixture of dichloromethane and sat. NaHCO3(aq) solution, at room temperature. The two phases were separated before the DCM was removed in vacuo. The desired 4-(pentafluorosulfanyl)phenyl isothiocyanate product was used without further purification to prevent potential hydrolysation of decomposition and added to a DMSO solution of 13. Compound 10 was afforded in a 33% yield. To prepare compound 5, 4-pentafluorosulfanyl aniline and a small excess of triphosgene were dissolved in toluene and heated to 70 ℃. Triethylamine (TEA) was added immediately to neutralise HCl forming in the reaction. After work-up, a solution of 13 in DMF was added dropwise to the solution of 4-(pentafluorosulfanyl)phenylisocyanate in toluene to afford 5 in 63% yield.