Considering the electrostatic contribution, for both vitamin D2 and D3 we find that water < ethanol < butanone < cyclohexane. Vitamin D2 and D3 contain a single hydroxyl (OH) group capable of donating and accepting a hydrogen bond, so this trend is not unexpected. Both molecular dynamics and uESE predict the same qualitative trend. We do note, however, that the numerical values a different. As compared to the molecular dynamics predictions, uESE predicts that the electrostatic contribution in water, ethanol, and butanone do not vary significantly.