Research on physical exercise as an intervention for aging indications are well established and clinical trials are seeing promising results. The Central Arkansas Veterans Healthcare System has completed a clinical trial on the use of Wii-Fit exercises to improve unsteady gait and postural balance in 30 veterans aged 65 and over. The intervention was performed for 45 minutes, 3 days a week for 8 weeks. Outcome measurements of gait and balance improved significantly in the intervention group, showing that the Wii-Fit exercise program was effective. Another study from the University of Kansas Medical Center recently published results for its clinical trial (NCT04009629) researching moderately intensive aerobic exercise and its effects on brain blood flow and biological factors after exercise (15 mins) in participants with a genetic risk factor for developing Alzheimer's disease. 61 participants aged 65-80 years old with the apolipoprotein e4 (APOE4) gene were enrolled. The results revealed increases in cerebral blood flow and neurotrophic response to acute aerobic exercise for all participants regardless of APOE4 status. The long-term goal of the study team with this acquired knowledge is to create a personalized exercise prescription for the treatment of Alzheimer's disease.