Exploring non-model species Most biological materials of interest are typically found in species less studied than model organisms (Table ). However, growing an organoid relies on preliminary achievements such as cell culture conditions, stem cell identification and a certain understanding of growth factors . This poses a central challenge to material-producing organoids, introduced here and further addressed with emerging solutions in following sections. Intraspecies variability already illustrates the difficulty of generalizing findings between individuals, notably in personalized medicine 277 . This issue is further complicated by interspecies variability, notably with greater phylogenic distances . Collegial efforts are necessary to unravel new cell identities 279 , signaling cues 280 , gene regulatory networks 281 and differentiation pathways 282 , to cite a few. The development of the first organoid relied on decades of research on dissociationreaggregation experiments, embryoid bodies, 3D culture systems and iPSCs . In comparison, recent developments of organoid protocols in new tissues have accelerated rapidly in the past fifteen years 275 . For instance, hair follicle organoids have advanced due to progress in tissue regeneration , growth factor discoveries 286 , niche characterization 287 , embryonic cell aggregation , stem cell differentiation media 290 , and patterned hydrogel scaffold development 291 .