We studied the mechanism of the fragmentation of active droplets and tested different parameters to tune the fragmentation. We verified that the long PSS remains inside slightly longer than the coacervate droplets than the short PSS, providing the long PSS enough time to mature inside the coacervate droplet to form denser domains, which are then liberated. Adding a second batch of chemical fuel at the right time can rescue the offspring. Their growth is faster than new nucleated droplets, giving them an advantage. Our findings enable a synthetic, self-sustaining protocell to undergo growth, division, and replication by introducing a set of selfreplicating molecules. The replicator should be designed so that the fragments that contain a replicator survive longer than the ones without. The longer-lived fragments can survive longer until the next batch of fuel is needed. Such coupling between a primitive genotype and phenotype could lead to Darwinian evolution in a synthetic system.