Again, in general we find that the predicted values of ln γ ∞ i,j do not change substantially when ∆G self i,i was predicted or computed using reference vapor pressure data. However, when water is the solute, there is a clear difference. This would suggest that when water is the solute of interest, both ∆G solv i,j and ∆G self i,i should be computed consistently in the calculation of ln γ ∞ i,j . In fig. we additionally point out that we observe an apparent break in our trend for reference values of ln γ ∞ i,j > 9. For all cases when the reference values of ln γ ∞ i,j are greater than 9, we under-predict the value of ln γ ∞ i,j . These would correspond to highly non-ideal (unfavorable) systems. For all 26 cases, water is the solvent. A possible source of error could be due to the difficulty of experimentally measuring such non-ideal values .