Golgi complex . According to Ra calculation, the structural isomers i.e. A-pBuOx-A/A-pPrOzi-A and A-pPentOx-A/A-BuOzi-A exhibited similar compatibility for BRF, while the later pair are supposedly better solubilizer than former (Figure ). As expected, pMeOx being hydrophilic showed the least compatibility. In this case, the formulation results were in accordance with the compatibility profile. The structural isomer pair, A-pPentOx-A/A-BuOzi-A were found to be better and capable to solubilize ≈ 0.40/0.33 g/L BRF (LC ≈ 4/3 wt.% and LE ≈ 20/8%), respectively (Figure ). The in-house BRF aqueous solubility was found to be 0.15 g/L (Table ). For the treatment of metastatic breast cancer, Yu et al. reported the nanoparticles based co-formulation of Brefeldine and celecoxib, where solubility of BRF was found to be ≈ 0.29 g/L . Unlike other, ultra-high drug loaded POx/POzi formulations , we can say that for the BRF, POx/POzi based amphiphiles are hardly solubilizers, but still performed better than previously published systems.