Furthermore, the Oxygen site in TIP3P-FB carries a partial charge of -0.848 e. In contrast, OPC3 exhibits a smaller geometry, with d OH and d HH equal to 0.098 nm and 0.160 nm respectively. Additionally, the Oxygen site in OPC3 has a charge of -0.895 e. The variability observed between the optimized models may be attributed to an intrinsic limitation arising from the simplified description of the system. Furthermore, as both models are trained solely on average parameters derived from a top-down approach, it becomes intriguing to explore the potential advantages of integrating additional data on microscopic target features through a bottom-up approach.