Only the coordinates of the two proteins and the stabilizer at the ternary interface were considered in the eight PROTACs-mediated ternary complexes (PDB ID: 5t35, 6sis, 6boy, 2hay, 2hr2, 7jto, and 7jtp), i.e., water molecules, ions, and other co-crystallized compounds were ignored. Coordinates of missing and mutated residues from the experimental structures were generated with MODELLER v10.4 . The coordinates of the other 14 ternary complexes listed in Table were taken from Ref. .