The speed-up of a TB calculation compared to, for example, a regular GGA(PBE) DFT calculation, is about three orders of magnitude, at little loss of accuracy for common properties like electronic and geometric structures. Thermochemical data and, in particular, conformational energies are generally not so well described, which is at least partially attributed to the small (mostly minimal) AO basis sets employed. The development of more accurate, but still sufficiently fast, TB methods is an important future field that should take advantage of more on advanced DFAs.