In this context, nanotheranostics, integrating various therapy and diagnosis motifs in nanoformulations, has emerged as a prevailing candidate to achieve versatility of precise theranostics. Nevertheless, it is unsure whether these motifs would not interfere with each other and maintain their individual original property in the nanoaggregates. Generally speaking, the properties of molecules may be affected after aggregation. For example, conventional organic luminogens are commonly π-conjugated molecules with rigid planar structures, and exhibit bright photoluminescence in the solution state; yet these molecules are enslaved to the aggregation-caused quenching (ACQ) effect in the aggregate state owing to the detrimental intermolecular π-π stacking interactions between individual molecules, leading to undesired energy loss together with impaired fluorescence emission and weakened reactive oxygen species (ROS) generation. Therefore, it is of great significance to develop versatile nanoplatform in which each motif serves its original purpose and even emerges synergism effect after assembling together.