Parent molecules and their docked cavities (A3A ssDNA and dimer-interface) for DataWarrior-Build Evolutionary Library (DWBEL) co-evolution, were selected by ADV blinddocking (see below ADV docking) of 37 home-designed 3-and 4-arm star-shaped molecules of several small molecular weights. Designed in 2D, their 3D conformers were generated using the mmff94s+ force-field algorithm supplied by DW (Supplementary Materials / 37star-mmff4s+.sdf ). DWBEL co-evolutions were performed during 3 consecutive runs with the same preference criteria: relative maximal relative weight for docking-score of 4 (x4), optimal molecular weight <= 600 g/mol (x2), low-medium hydrophobicity LogP <=4 (x1) and minimal Toxicity risk <=1 (x4). DWBEL co-evolutions randomly added/inserted small atom variations into the parents to originate tens of thousands of consecutively ID numbered raw-children. The selected non-toxic fitted-children were finally filtered by a DW macro (NTN) to exclude hundreds of molecules with any remaining mutagenesis, tumorigenicity, reproductive interference, irritant molecular signatures, and/or nasty motifs 47, 50, 51, 53, 55 , reordered by affinities, mmff94s+ conformers generated and saved to sdf vs3 file (Table ). To explore for increased affinities, iterations of DWBEL co-evolutions were performed using each ADV leadchild from the previous cycle as parent. The lead-child was supplied in an sdf file before their ADV docking to avoid pdbqt files which were not correctly interpreted by the DW algorithms. The number of raw-children corresponded to the total randomly generated new molecules after co-evolution of 3 consecutive runs from each star-shaped or lead child parents. The number of Non-toxic Fitted-children corresponded to the best-fitting children and A3A targeted cavities. The maximal ADV affinites were predicted by ADV blind-docking targeting the ssDNA-binding site with star8-derivatives (centerofmass 4.4x35x-25.6 Å and 20x20x20 Å grids) and the dimer-interface with star36-derivatives (centerofmass 27x42x-12 6 Å and 20x20x20 Å grids).