While findings in primates are more applicable to humans, rodents are more amenable to a wider range of experimental manipulations. Indeed, a study used female rats to show that THC increased D1 receptor density in NAc. As for male rats, decreased D1 receptor density in PFC was reverted by adolescent THC. Additionally, maternal deprivation (MD) can induce behavioral responses via D1 and D2 receptors and NMDA receptors, glutamate receptors which play a crucial role in synaptic plasticity, which can be modulated by THC . One study dosed male rats with THC and measured the number and affinity of D1 and D2 receptors in the striatum. They observed a loss of spontaneous motor activity following oral doses of THC. This correlated with a decrease of D1 receptors in the striatum . Others have discovered a relationship between THC and D1 receptors such as Komeili et al. (2021), which have found that in male rats with 6-hydroxydopamine-induced substantia nigra lesions, dosing with marijuana extract led to an increase in PSD-95 and D1 receptors .