Reaction products were measured in 1077 out of 1876 syntheses by our quality control protocol, representing a 57.41% success rate across all iterations. We soaked the crude reaction mixtures onto protein crystals at the XChem fragment screening facility at Diamond Light Source (Fig. ). This yielded 969 usable X-ray diffraction datasets for the crude reaction mixtures with successful syntheses, which translates into a crystal deterioration rate upon soaking of crude reaction mixtures of only 8.73% (Fig. ). This demonstrates that our new automated synthesis workflow pairs well with the pre-existing downstream high-throughput crystallographic pipeline and can generate a high volume of usable data in a relatively small amount of time while maintaining crystal integrity. Furthermore, the quality control step supplements the workflow by allowing tractability of reaction outcomes facilitating the tracking of which electron density maps could be expected to have a bound reaction product. Baker et al., (2020) processed 83 reaction mixtures in triplicate whereas our workflow performed a single crystallographic readout per compound. They demonstrated that performing triplicate experiments recovers more product-bound structures, thus it is likely that some binders were missed here. The aim here was, however, to increase the number of synthesised follow-ups using cheap robotics prioritising volume over quality whilst reducing times. Here a 22-fold gain in processing compounds or 7-fold gain in performing experiments compared to Baker et al., (2020). Design of larger arrays are also possible, but we purposely kept the size of the iterations at levels that are manageable for downstream XChem processing, which involves human interventions at certain steps such as crystal fishing.