the various cycles for Sc@(3,4,6,7,8) when 𝐸 ! , 𝐸 " , and 𝐸 # were targeted for optimization. In all cases, use of the FMQA approach generated more stable structures over fewer cycles compared to those required for random sampling. For the stable configurations determined by FMQA optimizations using 𝐸 ! and 𝐸 " , configurations were changed by performing further relaxations.