The continued interest in NPs has catalyzed the creation of compound databases including natural products. The rationale behind this lies in the crucial influence of database structural diversity on the success of drug screening. NPDBs provide a distinct advantage in this context, as natural products and their derivatives exhibit greater physicochemical and structural diversity when compared to synthetic compounds. Consequently, they cover a broader spectrum of chemical space. These databases not only aid drug development in developing countries but also highlight biodiversity , .