Encouraged by the above result for the synthesis of 2a, various hydrophobic N-protected γamino β-keto esters were synthesized (1b-1f) and kept for the reaction in ethanol to obtain desired 1,4-DHPs, shown in Table . Later to investigate the interference of side-chain functionalities and different amino acid protecting groups in this reaction, (N)Cbz-protected keto -amino ester (1g) were synthesized and subjected under the same reaction condition to obtain product 2g. It is worth noting that the reaction is compatible with various hydrophobic side chains and amine protecting groups for the condensation of -keto esters of various amino acids to synthesize 1,4-DHPs. All 1,4-DHPs products were isolated in good yields after purification from silica gel column chromatography using hexane and ethyl acetate as solvent systems. Later we kept them for crystallization in Ethyl acetate and x-ray quality single crystal was obtained for 2(b), 2(e) and 2(f). The crystal structure of 2(f) is shown in Figure . The crystal structure shows the pyridine ring exists in planer conformation in all of the above. As per the reports in the literature, if no substitution is there at the para position the pyridine ring shows planer structure, which exactly matches our observations in the synthesized amino acidfunctionalized 1,4-DHPs.