For systems containing large salt concentration, 100 mM, the disparity between cpH algorithm and canonical simulations diminishes, but still remain very significant for intermediate and large pH, as is illustrated in Fig. . Figure : curve for colloidal suspension of 11% volume fraction in the presence of 100mM salt inside the system. The solid line represents RR-cpH algorithm, the dashed line represents the canonical simulation, the circles are the results obtained using rGCMCD and Eq. 1 to relate the pH of the reservoir to the pH inside the system. The solid (blue) squares are the result of pair-insertion algorithm, Eq. (10). Note that for large ionic strengths, Donnan potential vanishes, and canonical and grand canonical titration curves become identical.