The paracetamol process also creates considerable amounts of wastewater, including halogenated, acidic, and neutral waste streams. These wastewater streams mainly originate from process steps II, IV and V, where larger amounts of water are required for product separation. However, strategies for handling aqueous process wastes were not investigated experimentally. Instead, a model for the treatment and disposal of wastewater streams was constructed using a model for the treatment of industrial wastewaters from the literature. In this context, it was determined that the mixed aqueous wastes leaving the novel paracetamol process likely require work-up through mechanical-biological wastewater treatment followed by incineration of generated biological sludge. The modelling of wastewater treatment strategies is described in Section 2.5. The predicted process flows associated with the mechanical-biological treatment of aqueous process waste and with the incineration of excess biological sludge were summarised into wastewater treatment LCIs which are given in SI Section S6.4, Tables and.