Table -Summary information for the datasets employed in this study. The number of hits defines the number of active compounds in the primary screen. The false positive percentage identifies the fraction of active compounds in the primary screen that were found to be inactive in the confirmatory screen. Each dataset is generated from a primary screen, relying on single-dose measurements, and confirmatory screen, which either adds replicates or assesses dose-response activity against the same biological target. To define which molecules are considered bioactive in a given primary or confirmatory screen, we employ the original activity thresholds defined by the authors of the screening campaign. This ensures that our analysis accurately reflects real drug discovery campaigns as close as possible, where bioactivity criteria vary on a case-by-case basis, depending on the biological target and the purpose of the drug.