In this paper, we examine data from the CAS Content Collection. The CAS Content Collection is the largest human-curated collection of published scientific information, supporting comprehensive quantitative analysis of global research across parameters including time, geography, scientific discipline, application, disease, chemical composition, etc. Covering scientific literature published around the world in more than 50 languages, the CAS Content Collection encompasses data and discoveries published in more than 50,000 scientific journals and by over 100 patent offices. A major advantage provided by the CAS Content Collection is that, along with the standard reference information, it also provides human curated data on major substances and concepts explored in the scientific publications. The CAS REGISTRY® , the authoritative source for information on more than 250 million unique organic and inorganic substances and 70 million protein and nucleic acid sequences, is part of the CAS Content Collection. The CAS Content Collection is broadly accessible through CAS solutions including CAS SciFinder® and CAS STNext® 21 .