The observed frequency of activity for the selected PNPs suggests that in the assembly of a PNP-library from commercial sources or through synthesis, a balanced approach should be used when onsidering the ompound's physi o hemi al properties (in particular, nSPS and MW) . Thus, if desired, a PNP screening library that promises to yield numerous hits with novel bioactivity is, in principle, readily available commercially without the need to design and execute laborious and time-consuming complexity-generating (asymmetric) syntheses programs.