The field of regenerative medicine is progressing very rapidly and is enabled by a broad range of supporting technologies, from stem cell and RNA technologies to protein engineering and soft matter and polymer design . Polymer brushes play an increasingly important role in this space and have been applied broadly to biointerface engineering . For example, some polymer brushes such as those based on oligo(ethylene glycol metharcrylate), hydroxypropyl methacrylamide or zwitterionic monomers display unmatched protein resistance in a range of complex biological fluids, with application in biosensing . Polymer brushes have been proposed for the long term culture of pluripotent stem cells and thermoresponsive brushes such as poly(N-isopropyl acrylamide) and poly(diethylene glycol methacrylate) have also been applied to the design of culture platforms enabling the non-enzymatic release of cells and cell sheets . More recently, dense polycationic brushes have been proposed for gene delivery and were demonstrated to be particularly performant to the delivery of oligonucleotides . Poly(dimethyl aminoethyl methacrylate) (PDMAEMA) and poly(2-methacrylolyloxyethyltrimethylammonium chloride) (PMETAC) were found to enable the delivery of siRNA and plasmid DNA with high efficiency , and to allow sustained reduction in protein knock down up to at least 10 days, beyond the window of efficacy of gold standards in vitro delivery platforms such as lipofectamine . Block copolymer brushes were also found to enable maintaining the stability of associated vectors in complex media solutions (serum containing medium) and reduce cytotoxicity, without compromising on the excellent performance of these systems for protein knock down .