The first objective of this research was to employ molecular dynamics simulations (MD) to reproduce and study the bindings that may naturally occur between different SARS-CoV-2 RBD variants and ACE2 in the presence and absence of folic acid metabolites. The simulation consist of building a box, adding the RBD, ACE2 and, depending on the scenario, one of the folic acid metabolites. Then, the box is filled with water and the system is neutralized with electrolytes. The final steps are running the simulation and studying the interactions between the RBD and the ACE2 throughout the simulation time (trajectory). The final objective is to find if the folic acid metabolite prevents the binding of RBD with ACE2.