Identifying functional groups which are more prevalent in our sets of interest could be informative for future force field parameterization. To this end, we used Checkmol to describe the combination of functional groups in each molecule. When given a molecule, Checkmol provides a list of descriptors for the functional groups it has. We count the number of molecules overall and in each set of interest that display each descriptor. From there, we can determine the most over-represented descriptors in each set of interest. We only considered descriptors and descriptor pairs that appeared at least twice in our full molecule set.