While these combined metrics provide a complete evaluation of computational workflows used in CACHE #2, a list of six well-performing workflows was compiled for further analysis, including WF1454 and WF1456, which had the best two aggregated scores, WF1414, WF1448, and WF1419 which predicted the three best scoring chemical series, and WF1438 that did best in predicting hits out of the 1957 Round 1 compounds (Figure ). Importantly, absence from this selection focused on top-performing computational pipelines does not imply that a workflow failed.