For selecting natural compounds, I began with the COCONUT database, which contains over 400,000 natural compounds (as of January 2024). I selected about 1% of the compounds for this database by applying the Lipinski, Ghose, Veber, Reos, and drug-like filters, and limiting the number of atoms to the range of 28 to 62. This selection resulted in 3,987 compounds, with 3,985 having acceptable SDF files for our current SDF reader.