The ionotropic glutamate receptor C-terminal (IPR001320) falls into three categories: AMPA (-amino-3-hydroxy-5-methyl-4-isoxazole-4-propionic acid), kainate receptors, and NMDA (N-methyl-D-aspartate). It is believed that they are instrumental in the process of synaptic plasticity. AMPA receptors mediate persistent changes in the intensity of synaptic transmission at numerous synapses in the brain, resulting from the transient activation of NMDA receptors. Additionally, kainate receptors can function as inductive stimuli for long-term changes in synaptic transmission. Ionotropic glutamate receptors (iGluRs) are a family of ligand-gated ion channels that are found in animals, plants, and microorganisms. Their most important function is to communicate between synapses in the vertebrate nervous system. Drosophila melanogaster initially identified Ionotropic receptors (IRs), a non-glutamate-binding chemosensory receptor subfamily of iGluRs. They detect smells and flavors.