To combine the PFP and SC-AFIR, we developed an interface code between the Matlantis platform 55 and Global Reaction Route Mapping (GRRM) program , where the PFP and SC-AFIR are available, respectively, to enable on-the-fly kinetic simulations of large systems. As a case study, this combined approach was used to study the complete oxidation of methane on the Pd(111) and Pd(100) surfaces. The Gibbs energy profiles of the most kinetically feasible paths were compared with DFT-based profiles reported in the literature.