. The human immunodeficiency virus (HIV) codes for the Viral infectivity factor (Vif) protein to activate human proteasome-degradation of human viral-inhibitor APOBEC3G (A3G). A3G is the most important single-stranded DNA deaminase enzyme inhibiting HIV by hypermutating its genome . Inhibition of Vif has been the target for abundant therapeutic research hampered by the lack of 3D models of Vif interaction with human proteins including highly insoluble A3G .