To quantitatively evaluate the difference between the LRMS and HRMS workflows for polyphenols, a sensitivity comparison was performed by calculating the LODs of reference standards (Table ) in HRMS spiked at a low level (level 2, Table ) in the three matrices. To keep conditions as similar as possible, the same concentrations were used as in the LRMS method. However, due to the different sensitivities of the instruments, a chromatographic peak could not be integrated for certain analytes. Thus, the LOD calculations were adapted to the number of replicates, or if less than three replicates were available, medium or high spiked samples were used instead.