On the Gibb deep cavity cavitands (GDCCs), OA and exoOA, as in previous SAMPL challenges, simulation based methods with empirical fixed charge energy models performed relatively well. Binding affinities for guests with adamantane, aromatic and saturated cyclic carboxlylates with OctaAcids were predicted with greater accuracy than TrimerTrip. Performance of methods within the GDCC dataset (OA and exoOA) demonstrates significant variation by guest, and especially when the formal charge of guest differs (negative vs positive).