Bacterial Chemical Fraction Library Generation: All bacterial strains were grown in 1 L of YEME, R2A and A-media in seawater (see Table ) containing HP-20 (15 g/L), XAD4 (7.5 g/L) and XAD7 (7.5 g/L) resins that captured the produced metabolites. Cultures were grown for 7 d at 30 °C, shaking at 200 rpm. After 7 d, the resins from each media condition were combined, and the cultures were filtered through miracloth in order to capture the resins. The combined resin mixture was extracted with methanol (MeOH) and acetone for up to 16 h. The organic extracts were combined and dried on 4 g of celite to yield crude extracts. The crude extracts were semi-purified with flash chromatography using 8 g of Phenomenex Supra C8 (50 μm, 65 Å) with a step-gradient -100% H2O (A -40 mL), 15% MeOH/H2O (B -40 mL), 30% MeOH/H2O (C -40 mL), 45% MeOH/H2O (D -40 mL), 60% MeOH/H2O (E -40 mL), 80% MeOH/H2O (F -40 mL) and 100% MeOH (G/H -80 mL). Eluent was transferred to a 40 mL vial and mixed thoroughly. An aliquot (3 mL) of each fraction was transferred to deep 48-well plates (VWR: 12000-728) with the fractions of each individual bacterial strain representing one column of the plate. Plates and vials were dried under vacuum. Vials were tared upon drying to completion and these weights were used to back calculate the amount of material in individual wells. Each fraction in the deep 48-well plates were resuspended at 10 mg/mL or 50 mg/mL when not possible to resuspend at the lower concentration. Fractions were then transferred manually to 96-well plates. Fractions originally at 50 mg/mL were then diluted to 10 mg/mL at this point.