As many CECs are poorly removed by WWTPs , the analysis of CECs in freshwater systems is critical for investigating their environmental fate and exposure to aquatic ecosystems. CEC concentrations in surface waters can highlight potential spots for concern or identify CECs that may need further investigation. In the European Union alone, there are over 100,000 chemicals approved for use . Whilst the advancement of analytical tools such as high performance liquid chromatography tandem mass spectrometry (HPLC-MS/MS) has allowed for the analysis of a wide range of CECs in water , prioritizing which chemicals to focus on is therefore a challenge.