We implemented various AFFF methods differing in the crossflow profile and the initial crossflow rate applied. Constant, linearly decreasing, and exponentially decreasing crossflow profiles were assessed to find an optimal compromise between recovery and resolution. With a linearly decreasing crossflow profile and an initial flow rate of 0.5 mL/min, we achieve better results (𝑅 = 79% and 𝑅 𝑆 = 1.2) than with constant or exponentially decreasing crossflow profiles.