We downloaded the proteins associated with "Autotransporter" from the UniProt database. We then used the MEME local version tool to compare them one by one to the viral proteins to identify conserved domains. We combined the motifs by protein and domain. Table shows structural proteins (S, N, E, and M) and non-structural proteins (ORF3a, ORF8, ORF7a, ORF7b, ORF6, ORF10, nsp2, nsp3, RdRP, and 3'-to-5' Exonuclease) almost all have longer autotransporter domain (SSF103515, IPR036709, IPR005546), except some ORF1ab sub-proteins. On a sequence-wide scale, S, N, M, ORF3a, ORF7a, and ORF8 almost all possess the autotransporter domain. It indicates that SARS-COV-2-infected cells secrete viral proteins into the blood and surrounding tissues via autotransporter. Therefore, ORF3a proteins could enter the blood and invade red blood cells.