Our systems throughout this study belong to two different phases of ZIF-4: the crystal and the melt-quenched glasses. The first amorphous MOF discovered and studied in detail, ZIF-4 has since been the subject of numerous works and can be seen as a prototypical amorphous ZIF system. It is built up from Zn 2+ metal nodes and imidazolate (Im) organic linkers, which are organized in the crystalline state as Zn(Im) 4 tetrahedra linked by Zn-N coordinative bonds as illustrated on Figure . The amorphous phases can be formed from the parent crystal by a variety of experimental methods, including ball milling, melt-quenching, or pressure-induced amorphization. Out of the many finite temperature mechanical properties that characterize anisotropic materials, in this study we will mostly focus on the bulk modulus (K) which characterizes the variation of the volume (V ) of a solid under uniform hydrostatic pressure (P ) and is defined as K = -V (∂P /∂V ) T . This property is the most readily available experimentally, and provides key information relating to applications, including about the MOF stability during the shaping process or pressure swing adsorption (PSA) cycles. To this date, multiple experimental and computational values for the ZIF-4 crystal have been determined and are listed in Table . K is comprised in the 1.4-2.7 GPa range for systems at a density (ρ 0 ) around the crystallographic density 3 of 1.22 g cm -3 , corresponding to a phase called open-pore (op) in the two latest experimental works that have focused on low-pressure behavior. Comparison between experiments and computational works is not straightforward as the measurements are complicated by subtle differences between MOFs from different batches (e.g. unintended defects incorporation during synthesis and different degrees of activation) and are dependent on the experimental setup (e.g. pressure transmitting medium). Additionally, computational values reported so far are either computed at 0 K or performed at a low level of theory, with no ab initio value at finite temperature reported in the literature for the ZIF-4 crystal.