Endocrine disorders and their treatments often have pronounced effects on tissue biomechanics. For instance, diabetic treatments like insulin therapy can restore normal glucose levels but may also influence tissue stiffness and elasticity. The biomechanical alterations in tissues, from glycation of structural proteins to changes in extracellular matrix composition, highlight the complex relationship between biochemical disease mechanisms and physical tissue properties . For example, the thickening of basement membranes observed in diabetic patients can be attributed to chronic hyperglycemia, which alters the biomechanics of blood vessels and affects tissue perfusion . Therapeutic interventions, such as insulin therapy, must consider these biomechanical changes to effectively restore metabolic balance.