As in the Wnt/β-catenin pathway, non-canonical signaling stimulates osteoblastogenesis when osteoclastderived Wnt binds to osteoblastic receptors . Contrarily, non-canonical signaling can inhibit or stimulate osteoclastogenesis . Osteoblast-derived Wnt-16 inhibits osteoclast differentiation directly by activating osteoclastic receptors. However, it indirectly stimulates osteoclastogenesis by activating osteoblastic receptors that upregulate OPG production . Together, these findings highlight the complexity of Wnt signaling and its regulation of bone remodeling. Wnt and Wnt signaling henceforth refer to the canonical Wnt/β-catenin pathway since new osteoporosis treatments target it.