For MD the GROMACS software version 2018.7 was used on a supercomputer in which each node had an Intel(R) Xeon(R) CPU E5-2680 v4 @ 2.40GHz 14 cores (28 threads) and four GPU NVIDIA(R) Tesla(R) P100-PCIE-12GB(R) cards. Four different experimental scenarios were designed, one acted as control and three more, as interventions.