In contrast, for atomwise attribution, a substantial average absolute difference is observed even for neighboring atoms, but a lower absolute difference is present for a distance of two bonds. The ubiquitous methyl groups can explain this counterintuitive behavior in our dataset since adjacent carbon atoms (non-terminal) are not eligible for explanations, as demonstrated by a low count of atomwise pairs at a distance of one bond in Figure . The frequent occurrence of neighboring methyl groups is also reflected in Figure , which explains the lower average absolute difference at a distance of two bonds since neighboring methyl groups have a topological distance of 2 and identical explanation values due to symmetry. statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit .