Various pharmaceutical companies have significantly contributed to the available KRAS knowledgebase, with several publicly available structures of KRAS SII-P binders (Table ). To date a total of 57 KRAS SII-P binder co-crystal structures have been deposited to the PDB by pharmaceutical companies. The top contributors (measured by the quantity of the deposited structures) are the companies Amgen (10) and Mirati therapeutics (12), both of which have the clinically approved drugs, these are accompanied by Boehringer-Ingelheim (11), AstraZeneca (8) and Novartis (5) among others.