In mixed systems for the butylbenzene ligand, we find that, on these simulation timescales, there are no meaningful slow motions in the 4w52-butylbenzene system (Figure ) and only identify a single state for that system (Figure ). We also find that none of the frames in the 4w52-butylbenzene trajectories sample the bridge region of the TICA space, which we previously hypothesized was the intermediate state (Figure ). However, we observe sampling of the bridge region in the 4w59-butylbenzene system. In this system, the slowest motion corresponds to an exchange between the bridge and oval-shaped regions of the TICA space (Figure ). We subsequently identify two states for the 4w59-butylbenzene system (Figure ).