The following experimental setup was used, as pictured in Figure , as described in the Methods section of the paper. Solubility studies were initially conducted to determine the maximum concentrations of each starting material and product in different solvents. This information would then be used to conclude the ideal concentration of the starting material in each reaction (0.09 M) and the solvents of choice to help to prevent reactor clogging. In each study, a pre-weighed vial and a fixed amount of material was dosed with small amounts of solvent and stirred vigorously until the material was fully dissolved -the vial was then weighed, and the resulting concentration calculated. These maximum concentrations are reported in Table : The weighing of the individual components into the sample vials differed for each of the case studies -these vials were used by the liquid handler as solution reservoirs. The vials 1 -5 contained these differing components, whilst vials 6 -25 remained constant throughout. 10 mL of reaction solution was present in each vial, which was each purged with nitrogen. The triethylamine and all solvents are anhydrous, and biphenyl was used as an internal standard. These concentrations were calculated so that a constant 0.09 M concentration of starting material in the reactor could be obtained through dilution, to enable a fair comparison between all conditions where mol% of catalyst was varied. The weights of all components are displayed in Table and S3: