The proposed catalytic cycle depicted in Figure begins with the Fe 2+ (OH) site of the MOF platform (labelled M). Addition of the oxygen source N2O and breaking of the N-O bond via the transition state TS NO yields N2 and the active iron-oxo species MO. Methane can interact with and be activated by the MO site, resulting in a methyl radical and Fe 3+ (OH)2. Recombination of the methyl radical with one OH group in a so-called rebound step leads to adsorbed methanol, which can desorb as the desired product to regenerate the initial MOF site M.