Given the high kinetic barrier of the mechanism explored in the last section employing ad-hoc collective variables, we further explored other possible reaction mechanisms of potentially lower barrier. To this aim, we adopted a general-purpose set of collective variables, called SPRINT, designed to discover without prejudice the possible ways a system can change the bonding network (topology). We tailored the coordinates to track changes in the short-and long-range topology of i) the first interface methanol layer (L1), identified for each system by the first peak of the corresponding density profile (see Fig. ), and ii) two large areas (16 carbon atoms each) of both the upper and lower Graphene layers (see Fig. in the S.I.). The two regions were chosen approximately on the top of each other.