Of the 9,056 reactions only 1,583 have reaction energies below 30 kcal/mol and the barriers of these reaction were estimated using our RMSD-PP-based method (Figure ). Of these 1,583 reactions 64 of the reactions have estimated barriers below 50 kcal/mol and are thus checked with DFT. For seven of the 64 reactions TSs connecting the intended reactant and product are found using DFT, as verified by IRCs. Six of them correspond to the reactions depicted in Figure : two of them correspond to Reaction 1 (the two enantiomers of the product), two of them correspond to Reaction 2 (there are two ways of moving an H from the -CH 2 group, with TSs that are mirror images) and two of them correspond to Reaction 3 (either of the hydrogens on the reacting -CH 2 group can move resulting in TSs that are mirror images). The remaining reaction, depicted in Figure , has a barrier of 62 kcal/mol and a reaction energy of 18.8 kcal/mol and was not found in any of the previous studies . In addition, R28 showed up during one of the searches for another reactant and product pair and is discussed further below.