Unsurprisingly, product 3r turned out to be completely stable in CH3CN and DMSO as well as in water for more than 48 hours (Scheme 3, B). This compound also demonstrated high stability in acidic conditions (HCl 1M and pH 4) and in pH=7 buffer with more than 90% recovered. Rapid degradation was observed under basic conditions (pH 10 and NaOH (1M)). interestingly, very high stability under saline conditions was also observed.