Meanwhile, DNA nanotechnology in the field of data storage shows promise in addressing challenges associated with synthesis and reading. By leveraging the self-assembly properties of DNA strands, this technology enables the construction of intricate 2D and 3D architectures. Various methodologies, including DNA tile assembly or DNA origami, facilitate the fabrication of nanoscale forms and designs. These structures can store data in their three-dimensional shape rather than the sequence of bases. The non-covalent nature of DNA allows for easy reconfiguration using techniques like strand displacement, thermal annealing, and pH changes. This reconfigurability enables data erasure and rewriting without the need for chemical synthesis. Additionally, DNA nanotechnology offers the potential for encryption and data operations similar to computer memory systems. While data storages based on DNA nanotechnology fall short in terms of data density when in comparison with nucleotide sequence itself in encoding data, it still outperforms existing hard drive technologies by a significant margin. Moreover, there is room for improvement by fine-tuning three-dimensional DNA structures to achieve even higher data densities. Overall, DNA nanotechnology shows promise for data storage with advantages in readout, simplicity, and reconfigurability . It has been suggested that by synergistically integrating cutting-edge molecular biological tools such as CRISPR and DNA nanoengineering, remarkable advancements can be made in the domains of bio-computing and bio-storage. This integration offers improved speed and efficiency in the procedures of encoding and decoding DNA information. Additionally, advancements in synthesis and sequencing capabilities contribute to increased throughput and cost reduction, making large-scale DNA-based data storage platforms more practical. It is estimated that accelerated progress in DNA-associated technologies could be a great answer to the problem of data explosion .