To further prove the optimization capability, Figure shows a contour plot of the QED-Vina score distribution for Augmented Memory and AHC with experience replay. It is clear that the joint QED-Vina score distribution for Augmented Memory is shifted to higher QED values and lower Vina scores. The black dot is risperidone and the bulk density of AHC does not possess a better docking score. Finally, Figure shows an example binding pose of a molecule generated using Augmented Memory. We highlight that the chemical plausibility of the structure is enforced precisely because MW and QED are also included in the MPO objective, thus representing a more realistic case study.