Mitochondrial dysfunction has been proposed to play a significant role in Parkinson's disease pathogenesis. It can be induced by environmental toxins, particularly pesticides and herbicides attack the central nervous system leading to the development of neurodegenerative diseases . It is known that rotenone, a natural toxin has been used tremendously as an insecticide or fish poison for the past 50-150 years . Rotenone induces P.D. like symptoms in neurons by interrupting ATP (Adenosine Triphosphate) supply, by forming a complex with the membrane of the Electron Transport Chain .