In LaMer burst nucleation, uniform generation of solute (e.g. via chemical reaction 6 or addition of immiscible solvent 7 ) prepares nearly identical conditions throughout solution (in stage I/the prenucleation stage). The accumulating supersaturation eventually results in a burst of nucleation (in stage II/the nucleation stage), and subsequent growth reduces the concentration of precursor and prevents further nucleation (in stage III/the growth stage). Generally, this process is fairly quick, meaning the particles are born within a small period of time and are consequently monodisperse in size. LaMer and Dinegar's 1950 publication illustrates the process diagrammatically and is thus frequently cited for it. At high levels of supersaturation, nucleation is essentially guaranteed rather than occurring at random, which allows for the possibility of deterministic models. Sugimoto 11 introduced one such deterministic, macroscopic model in the form of an ordinary differential equation for the change in solute concentration, C, with time