There are various behavioral aspects that were studied when analyzing the relationship between THC and D1 receptors. For instance, a study using male rodents studied hedonic and aversion-like behaviors as a result of daily THC consumption and its subsequent spontaneous withdrawal. It found that anxiogenic-like and anhedonic-like behaviors, as well as neurochemical changes, were reversed by an interference peptide disrupting D1-D2 heteromer during withdrawal . Additionally, Mani et al. (2001) used female rats to study sexual receptiveness in response to THC. The study found that PR and D1 receptors were needed for the THC response. Additionally, it also suggests that THC-facilitated receptivity involves D1B (D5) receptors. One potential mechanism is that the effects of THC are mediated via CB1 receptors inducing dopamine release and thus stimulating D1 receptors . However, as the study was conducted only on female rats, the generalisability is limited. Therefore, future work should aim to investigate this mechanism in male rats. D1 and THC are also thought to influence feeding and motor control. Verty et al. (2004) used Wistar rats between the ages of 8-10, and have shown that cannabinoid-induced food ingestion can be involved with D1-like receptors. SCH 23390 was shown to attenuate THC-induced feeding when given at a dose that was insufficient to affect feeding when given in the absence of THC. SCH-23390 also attenuated locomotion affected by THC. In addition, when THC was given with SCH-23390, SCH 23390 did not show suppressive effects on locomotor activity . In further work investigating the role of THC on motor control, (de Fonseca F et al., 1994), chronically stimulated D1 and D2 receptors in male rats and observed the role of 11-hydroxy-delta 8-tetrahydrocannabinol-dimethylheptyl (HU-210), a cannabinoid agonist which is highly potent. It has been demonstrated that HU-210-induced catalepsy, as measured by descent latency in a bar test, was enhanced in the presence of SKF38393, which is a selective partial agonist of D1/D5 receptor. This result might suggest that D1 receptor plays a role in cannabinoid induced catalepsy . However, future work should aim to replicate this study in female rats to ensure the effect is not gender-specific.