Understanding the interactions between the antibody-IL-13Rα2 could be crucial in designing more promising CAR T-cells. Therefore, the current research explores the interactions between antibodies and IL-13Rα2 by performing molecular docking simulations. The results show that the antibody binds to the specific region of the protein, and out of 15 antibodies, we have selected one antibody (PDB ID: 1B4J) that binds strongly to the receptor and could be used for further experimental evaluations. This work will contribute to our understanding of the receptorantibody binding mechanism and assist in developing novel antibody-based CAR T-cell therapies.