This complex system depends on several hyperparameters related to the relative size of the RL and AL loops (𝑁 batch and 𝑁 acquired ), and our survey of these options demonstrated interdependence between these factors. Generally, the lower the ratio of 𝑁 acquired 𝑁 batch , the more scope the AL system has to improve upon baseline RL, in rough analogy to the size of virtual library in VS-AL methods . While our optimal configuration provided good performance on both oracle functions tested, it is likely that bespoke optimization of the configuration for the oracle at hand would lead to even better results.