Indeed, averufanin displayed a good antioxidant activity in terms of antioxidant capacity to Trolox , and weak activity against both acyl-CoA: cholesterol acyltransferase type 1 and 2 (ACAT1 and ACAT2) in the cell-based assay with IC50 values of 28 and 12 μM, respectively , whereas noraverufanin (36) exhibited a weak HIV latency-reversal activity with reactivation of 43.3% at 10 μM . Nidurufin which have been also isolated from the marine fungus A. niger and marine-derived P. purpurogenum G59 , showed weak antitumor activity against the bone marrow cancer cell line K562 with an inhibition rate percentage of 25.5% at a concentration of 100 μg/mL and moderate antioxidant capacity with 0.62 as Trolox equivalent as antioxidant .