Trypanosoma cruzi . Six to seven million people are estimated to be chronically infected with T. cruzi, mostly in Latin America, and are at risk of developing severe complications such as arrhythmia, dilated heart, or dilated colon, making Chagas disease an important public health issue . Current treatments -benznidazole and nifurtimox -are sometimes associated with severe adverse effects and suboptimal efficacy . There is therefore a need for new drugs targeting asymptomatic infections before complications appear .