In summary, Gram-positive membranes contain variable amounts of PG, PE, CL, glycolipids, menaquinones, and occasionally PC and plasmalogens. PG is overrepresented in the outer leaflet, particularly in its amino-acylated forms, which play a key role in AMP interactions. PE and CL localize to curved regions of the inner leaflet. Glycolipids are mainly antennae towards the external environment and accordingly preferentially within the outer leaflet, although in such species their abundance is so high that they are likely significantly present in the inner leaflet as well. MK, due to its high hydrophobicity, may flip between leaflets, possibly positioning also perpendicular to the membrane normal. PC lipids, implicated in immune evasion, reside mainly in the outer leaflet.