Therefore the signal of the unidentified chemicals in those samples remain unused. These unidentified signals may be of high enough quality to be identified using updated pre-processing strategies or expanded spectral libraries (i.e. retrospective analysis). In fact the retrospective analysis of combined data from multiple human cohorts resulted in additional inferences on the connection of chemicals and health outcomes can be made. In this perspective we are critically assessing the knowledge and technological gaps in our current chemical management strategies from the exposome chemical space characterization.