Contrary to the traditional GUV immobilizing approaches, an innovative and inexpensive approach to address this challenge is the immobilization of GUVs with MOFs. In 2021, we reported the use of zirconium MOFs to anchor GUVs on a timescale of minutes to hours owing to the affinity of zirconium ions to strongly bind phosphate groups in phospholipid membranes. We herein expand on this work, exploring the immobilization of vesicles with different lipids compositions to various micronsized MOFs, including MIL-53(Al) MIL-100(Al), MOF-177, Cu BDC, HKUST-1, MIL-53(Fe), MIL-100(Fe), UiO-66, MOF-808, Ca BDC and MgMOF-74. These MOFs were chosen for their varied chemical compositions and structural characteristics, which provide a basis for the binding of metal centres or ligands with lipid bilayers. We used lipid mixtures with saturated (1,2dipalmitoyl-sn-glycero-3-phosphocholine; DPPC), unsaturated (1,2-dioleoyl-sn-glycero-3-phosphocholine; POPC and DOPC) and negatively charged (1-palmitoyl-2-oleoyl-sn-glycero-3phospho-(1'-rac-glycerol); POPG) lipids in combination with cholesterol (Chol) in this study. The development of inorganic compounds that can interact with biological membranes is a crucial interface for the application of materials science in life sciences. In this study, we aim to bridge the gap by evaluating the phospholipid anchoring capacity of a diverse set of MOFs, examining their influence on GUV formation, size distribution, frequency of immobilization, and stability.