Herein, we have reported a simple and successful heterogeneous sample analysis method that we have implemented on six walk-up LCMS instruments which have been in operation for over 3 years. This method is easy to install and costs only a nominal amount per instrument to access the parts required. This has subsequently led to approximately a 95% reduction in the number of clogs. Decreased occurrences of clogging have increased the robustness and efficiency of our instruments while providing reliable chromatography for the users due to the elimination of pressure spikes. Most importantly, the system has resulted in significant savings in both consumables and time for both the chemists and instrument administrators.