Establishing and deconvoluting large mixtures of fluorinated compounds typically requires these compounds to have been measured in single experiments, so that their measured 19 F NMR chemical shifts can be used as references. This can be done once for a static library of fragments but quickly becomes prohibitive if such a screening library is to be constructed on the fly as a focused set for a particular target or using parallel chemistry. Every compound would have to be measured at least once to generate mixtures of non-overlapping 19 F NMR peaks.