The MACPF domain (IPR020864) is a membrane attack complex/perforin (MACPF) family component. The constituent elements interact sequentially and exhibit a high specificity in response to pathogen infection to form a transmembrane channel known as the membrane attack complex (MAC). MACPF has a low sequence similarity. Plasmodium's sporozoite microfilament protein contains the MACPF domain. It is required for cell division 2 (SPECT2). Table shows MACPF domains are found in structural proteins (S, E, M, and N) and non-structural proteins (ORF3a, ORF6, ORF7a, ORF7b, ORF8, ORF10, and ORF1ab).