Each shell is passed through a hash function to generate a series of "on" indices, which are collected into the final fingerprint following the extended-connectivity fingerprint protocol introduced by Rogers and Hahn. This one-time calculation occurs before the molecule is saved to the database, and the user can export the calculated IFPs. By default, Autoparty uses EIFP count fingerprints calculated with 2 shells of radius approximately 6Å and folded to a length of 4096, per the optimal settings for DOCK score prediction in previous studies. Fassio et al describe this fingerprint generation protocol and its initial chemical features in depth.