For a fixed charge model, the partial charges that best replicate QM ESPs for one conformation of a molecule are not optimal for other conformations, and this problem is usually referred to as conformational dependency 5,50 . Thus, losses in accuracy are inevitable when fixed charge models are used in simulations where the molecular conformation varies. We conjectured that the polarizable AM1-BCC-dPol and RESP-dPol model would better preserve accuracy across multiple conformations of a molecule compared to the non-polarizable AM1-BCC model, because of the ability of the inducible dipoles to respond to changes in field due to changes in conformation. As an illustrative test of this idea, we examined the transferability of the AM1-BCC-dPol and RESP-dPol electrostatic models across two conformations of alanine dipeptide, conformer 0 with an intramolecular hydrogen bond (Figure )