We ran metadynamics simulations using the PLUMED plugin for the version 2018.6 of GRO-MACS. Simulations were prepared and ran using the same methodology as the equilibrium dynamics. Metadynamics were initially ran for 30 ns and if the system had not converged, further extended for 5 additional ns, after which convergence was reassessed. A system was considered converged if both the height of the deposited gaussians and the free energy difference between the