The variation of electron mobility within the crystal structure landscape of a given molecule, and between landscapes of related molecules, demonstrates the important influence of crystal packing on this property: improved intermolecular coupling can more than make up for a moderate increase in the molecular reorganization energy. Within the molecules included in our study, we find that the most commonly favored crystal packing across all molecules investigated here is the γ packing motif, which is predicted to be favored for molecules with different point-group symmetry and functional group substitution patterns. Furthermore, sketch-map and cluster analysis suggests that crystal structures from different molecules that favor the γ-type packing exhibit a high degree of structural similarity, which can be attributed to the abilities of these molecules to form similar short-ranged hydrogen-bond patterns.