o1-preview Generation B2: Historical Paclitaxel Retrobiosynthesis Proposal from 10 Paper Summary **Retrobiosynthesis of Paclitaxel (Taxol)** Paclitaxel is a complex diterpenoid natural product widely used as an anticancer agent due to its ability to stabilize microtubules. Its intricate structure comprises an 8-membered taxane ring system with multiple oxygenated functional groups and a crucial C-13 side chain.