Researchers have demonstrated that many classic laminar-flow-based devices and processes developed in a microfluidic duct-based format can be recreated in simple and low-cost paper networks. These paper-based systems provide numerous advantages, including reduced costs, simplified fabrication, elimination of pumps and power requirements, and the removal of issues caused by bubbles that often occur in microfluidic systems. They are ideally suited for POC diagnostic applications in low-resource settings due to the low cost of materials, compatibility with dry reagent storage, ease of disposal, and lack of complex pumping/pressure systems or power sources.