It is also possible to get a more fine-grained control of flexibility through a continuous variable, with the use of a solid solution of linkers in mixed-linker MOFs. This was recently demonstrated by Bonneau et al. on the gated adsorption of acetylene in an interpenetrated MOF (see Figure ). In this work, the authors introduced in the Zn-CAT = Zn 2 (bdc) 2 (4,4 ′bpy) framework (bdc = 1,4-benzenedicarboxylic acid; 4,4 ′ -bpy = 4,4 ′ -bipyridine) linkers substituted with either -NH 2 or -NO 2 groups, in controlled amounts. The ligands are homogeneously distributed within the backbone structures, and thermodynamic modeling of the adsorption isotherms showed their presence has a dual effect: (i) change of the gating free energy of the framework, ∆F host , (ii) impact on the host-guest affinity, measured by the Henry constant, K H . As a consequence, the gating pressure upon acetylene (C 2 H 2 ) adsorption can be tuned through the linker composition, offering an example of design of MOFs with tunable uptake/release pressures for a desired guest molecule and operating temperature.