To solve the problems, the trade-off between LE and TADF with moderately twisted donor-acceptor structures can fully utilize their advantages and largely avoid their shortcomings (Fig. ). Therefore, organic scintillators with the character of hybridized local and charge transfer (HLCT) excited state are highly promising candidates to promote the overall scintillation performance. HLCT scintillators possess two combined and compatible characteristics: a LE state with a large oscillator strength and a charge transfer (CT) state with enhanced intersystem crossing (ISC) ability. Then the former one contributes to a high radiative rate and narrow emission spectrum, while the latter was responsible for the high triplet exciton utilization efficiency for the high-lying reversed ISC (hRISC) transition from upper triplet state (Tn) to singlet (S1) state, which leads to high PLQYs. The weak binding of CT excitons can contribute to a large Stokes shift and narrow energy gap between S1 and Tn (ΔEST), leading to a fast hRISC rate, which can intrinsically shorten the scintillation lifetime. These advantages can make HLCT scintillators perform well in RL detection and imaging.