Classifying those 238 images manually, 49 contain Markush like structures (for an example see figure ) or collections of substituents or scaffolds as part of the claimed compounds. Further, 187 images contain single or multistep reaction sequences that lead to the exemplified and claimed compounds of this patent. The claimed compounds are macrocyclic compounds with images that are most likely not very easy to translate into chemical structures. An example is shown in image S1 of the supplementary material . The final reaction product of the synthesis sequence shown in S1 was published by PubChem as CID 89807863 (PubChem: 89807863) and was found in a total of 8 patent documents. The underlying SureChEMBL () workflow uses, according to our information, the commercial program GLiDE for image-2-structure extraction. The same compound is also found by our SciWalker structure extraction, registered as OCID 190067469284 in 6 related patent documents, e.g. the related EP-2822953-B1 grant but not in application EP-2822953-A1 and grant EP-2822953-B9. Using OSRA version 2.1.3 to extract both reactions and compounds for SciWalker in production, we did extract 1539 unique chemical structures for EP-2822953-B9 () automatically. However, the OCID 190067469284 compound was missing among them -therefore we were interested in identifying an improved image-2-structure module to fuel our compound and reaction databases in SciWalker.