One important analysis usually not evaluated is the model performance out of the domain covered in the training set. The model ability to extrapolate or interpolate to other conditions not seen during the training phase has not been evaluated. To assess it, different experiments are performed for temperature, pressure, and molecules. For the different molar ratios of DES mixtures, the study of the HBA is not considered because of the lack of diversity of molar ratios included in the dataset. In the case of HBD molecules, the study was performed due to its high distribution of molar ratios.