Additionally repetition of data in the source datasets was scrutinized and where possible only the most recent bioactivity data was kept. This is for instance the case of the KIBA scores of Stereochemical aspects were discarded in Papyrus to ensure that differing molecular standardisation processes of sources would not have an impact on the aggregation of activity values. However, the procedure of removing stereochemistry completely overlooked the potential of chiral molecules having opposing therapeutic or toxic effects and does not allow for the modelling of activity cliffs.