Water contamination with heavy metals is a critical issue for modern societies. The Agency for Toxic Substances and Disease Registry and the U.S. Environmental Protection Agency (EPA) recently published the 2019 Priority List of Hazardous Substances that stated the most toxic elements including several metal ions, e.g., arsenic (As), cadmium (Cd), mercury (Hg), lead (Pb), and selenium (Se) . In this context, methodologies to remove as well as sense/detect these ions are highly required to advance the water treatment. To that end, MOFs, among several other materials, offer the possibility for heavy metal removal via adsorption as well as the detection of such contaminants using imaging-assisted sensing and electrochemical and optical sensing .