and filled with 1800 polarizable water particles. The larger water soluble protein HEWL was placed in a periodic rectangular box of 8.9×8.9×8.9 nm 3 and filled with 23000 CHARMM TIP3P water molecules for the AA simulations and 5400 polarizable water particles for the CG simulations. Na + and Cl -ions were added to all systems at 0.15 M concentration to neutralize the protein systems. The turkey ovomucoid inhibitor protein was placed in a box of 4.9 × 4.9 × 4.9 nm 3 with 3086 SPC water molecules. The GLIC protein was embedded into a bilayer membrane containing 498 phosphatidylcholine (POPC) lipids, placed in a box of 14.0 × 14.0 × 15.9 nm 3 , and filled with 66494 CHARMM TIP3P waters, 58 Na + , 123