The musculoskeletal system is a complex network of bones, muscles, tendons, and ligaments that provide structural support and facilitate movement. Pathophysiological conditions affecting this system, such as osteoarthritis, rheumatoid arthritis, and tendinopathy, can lead to significant impairment in quality of life. An understanding of the mechanisms by which chemical species transport and transformation occur is essential to elucidating the pathogenesis of these disorders. This review examines the roles of various transport mechanisms in the context of musculoskeletal disorders.