The global COVID-19 pandemic continues to wreak economic and social havoc globally, with at least 330 million infections and 5.6 million deaths globally (January 2022). Effective vaccines and drug therapies are essential to bringing the pandemic to an end. This global challenge has seen an unprecedented and intense focus on coronavirus research, resulting in the development of vaccines in impressively short times. Similarly, empirical and limited rational selection of drugs such as remdesivir and dexamethasone provided early drug treatments that limited morbidity and mortality. However, more effective drugs are still required to treat COVID-19 and other coronavirus diseases, such as SARS and MERS, as well as new viruses that may emerge in the future.