The metallacages provide several benefits: high symmetry, facile synthesis, simple modification reducing toxicity and overcoming drug resistance . Also, edge-or face-directed synthesis methods are the most common for synthesising metallacages . They are symbolised MxLy (M=metal, L=ligand, and x and y are their number.); for example, Pd 12 L 24 directed-type metallacages were synthesised . A guest bound a Pd 2 L 4 cage synthesised using the edge-directed synthesis method with the help of the H-bond, steric interaction, van der Waals, and Coulomb interactions between them . In addition, the metallacages are appropriate for encapsulating anions, cations, and neutral organic molecules . Therefore, cisplatin can be encapsulated with these kinds of metallacages to overcome the drawbacks of cisplatin, including toxicity, by accomplishing drug resistance .