The term "phytochemicals" refers to the bioactive non-nutrient compounds present in the plantbased diet. These compounds are responsible for the colour, taste and aroma of foods with a wide range of nutrients, minerals, vitamins and fibers. These molecules possess anti-carcinogenic and anti-mutagenic properties . Phytochemicals have been categorized on the basis of their chemical structure, origin and biological properties. The most common phytochemicals such as phenolics, alkaloids, carotenoids, organosulfur compounds, and nitrogen-containing compounds exhibit anti-cancer properties. Among them, carotenoids, phenolics, and organosulfur compounds have been studied for their therapeutic potential . It has been observed that dietary phytochemicals and their derivatives present in plants are promising options to improve treatment efficiency in cancer patients and can also be used to mitigate adverse reactions of chemotherapy . Till date more than 5000 phytochemicals have been identified in plants and plants derived food . A number of these phytochemicals are naturally occurring biologically active compounds having significant antitumor potential . It was also reported that phytochemicals potently inhibit migration of metastatic breast cancer cells . Some phytochemicals possess antioxidant activity and induce apoptosis in cancer cells and therefore play important role in prevention of breast cancer . Prevention of breast cancer by natural phytochemicals maximizes the treatment efficacy and minimizes harmful side effects caused by radiotherapy and chemotherapy alone . More recently observations of dietary phytochemicals in the spectrum of tumor types and incidence underlie the growing interest in the role of phytochemicals in the breast cancer prevention and therapeutics . The present therapeutic approaches for breast cancer such as chemo drug and endocrine therapy, and phytochemicals supplement by targeting multiple sites and different pathways involved in breast cancer progression. Further, the combinatorial therapeutic approaches led to enhancement of therapeutic efficacy, abatement of side effects and finally overcoming clinical challenges .