After an enrichment analysis of the 1,588 immune system proteins of the PPi network, the most significant KEGG signaling pathways were chemokine signaling pathway, TNF signaling pathway, NF-kappa B signaling pathway, IL-17 signaling pathway, TLR signaling pathway, and T cell receptor signaling pathway. The most significant Reactome pathways were immune system, innate immune system, cytokine signaling, signaling by ILs, neutrophil degranulation, viral mRNA translation, and chemokine receptors bind chemokines. Lastly, the most significant WikiPathways were chemokine signaling pathway, gastrin signaling pathway, TWEAK signaling pathway, regulation of TLRs signaling pathway, TCR signaling pathway, and IL-1 signaling pathway (Supplementary Table ).