[ 18 F]FSPG has been synthesized previously using the Eckert and Ziegler modular lab , the GE tracerLab and the scintomics HBIII platform . We started by adapting the automated synthesis procedure using the previously-published Scintomics HBIII platform methodology . Whilst [ 18 F]FSPG could be synthesized using this initial set-up, problems with isolation of the produced [ 18 F]FSPG prompted us to redesign the cassette layout.