We calculated the protein pocket properties for all 43 DUDE-Z proteins using the program fpocket. We ran fpocket in restricted mode with the crystal ligand provided by DUDE-Z, which allowed fpocket to characterize the ligand binding site explicitly rather than characterizing putative binding sites that may not align with the experimentally validated ligand binding site. We leave an exact overview of all descriptors returned by fpocket to the original manuscript, but at a high level, fpocket returned information about each binding site's volume, polarity, hydrophobicity, electrostatics, solvent accessibility, and druggability.