In Round 1, each team was asked to select up to 100 in-stock or make-on-demand compounds from the Enamine catalog, leading to a collection of 1957 compounds quite evenly distributed between participants (61 to 97 compounds each, Figure ). Participants were also encouraged to use badapple () to filter out promiscuous compounds , though doing so was not mandatory. Overall, compounds displayed drug-like properties, as reflected by the distribution of their Lipinski descriptors (Figure ). While three of the four fragments crystallized in the RNA site of Nsp13 included a carboxylic acid attached to a ring, compounds were diverse, as illustrated by a pairwise distance matrix of Tanimoto distances based on ECFP4 Morgan fingerprints calculated with RDKit (Figure ). Chemical diversity was also observed within selections from each team, with rare exceptions, outlined by darker squares along the diagonal of the distance matrix.