To obtain different mutations in PROTACs, CReM also called the Chemically Reasonable Mutations framework was utilized . CReM mutations are done by fragmenting the molecule into smaller subunits and are stored in a database. Next the mutations are performed by replacing fragments with other fragments from the database. During this step the valency, aromaticity, and functional groups are considered to ensure that the resulting molecules are chemically reasonable. Finally, multiple new structures are generated through iterative mutations. Based on the CReM web server we obtained 10 PROTACs in a SMILES format . SMILES are a chemical way to represent a chemical compound so it can be used by a computer.