Taken together, we have demonstrated that our reparametrized lipids together with the Martini 3 protein model can be used to study a broad range of protein-membrane systems at long-microsecond timescales, needed to effectively investigate proteinlipid interactions. However there is still room for improvement in the reproduction of certain protein-lipid systems, e.g. stable binding of peripheral proteins to known lipid partners, which we expect will require not only improvements in the lipid parameters but also changes to the current protein model . With the number of available Martini 3 lipid topologies now in the thousands, together with the natural variation of protein sequences, the possibilities of constructing and studying proteins in ad-hoc membrane environments are limitless. We therefore rely heavily on community feedback, both positive and which areas we should focus on improving, ideally backed by experimental results.