More work can be done in regards to improving move acceptance with NCMC. Potential areas to be explored could be to look into more efficient paths of turning off and on the electrostatics and sterics of the system. Different soft-core potentials could potentially be used as well, to further decrease the accumulated protocol work while turning on the ligand's interactions by minimize the variance of this process. Molecular Darting also has potential applications in combination with other methods, which can be further explored. For instance, MolDarting could find use in equilibrium or expanded ensemble simulations to improve sampling. In the non-interacting states, MolDarting moves should have significant acceptance rates; since there are no clashes with the surrounding atoms of the ligand acceptance will just depend on the ligand's internal degrees of freedom.