In addition to (arguably) more established applications in industrial and environmental control and disease detection through breath analysis, MOF-based SERS substrates are also of interest in the realm of organoleptic description. This research field deals with perceiving of aroma or taste, which is in reality a collection of molecular analytes recognized by multiple receptors in our nose and tongue, sending a complex and convoluted signal to brain. Sometimes, the same set of analytes but in different proportions render completely different organoleptic properties. To mimic then the sense of smell and/or taste is particularly challenging, because it is not ascribed to an individual analyte anymore, but a whole collection of them. . The detection of VOCs responsible for aroma and flavor adds a unique dimension to the applicability of MOF-based SERS substrates and it represents an interesting emerging research field.