This review has highlighted the diverse role of THC on D1 receptor density and the various behaviors influenced by the THC-D1 receptor pathway, such as feeding, sexual receptiveness and withdrawal effects. In addition, the D1 receptor is essential for mediating at least some of the effects of THC on motor control and cognition. These effects could be enacted via molecular pathways involving a number of molecules, including the BDNF/TrkB pathway, Fos expression, and ERK activation.