To explore the effect of phospholipid transfer on monoolein cubic phases, cubosomes were mixed with a nanoparticle dispersion of lipids isolated from Escherichia coli cells. Cubosomes were employed to overcome experimental and practical challenges; the behaviour translates to the bulk material given that liquid crystal structure is maintained internally within the nanoparticle, while the surface layer of polymeric steric stabilizer does not prevent inter-particle lipid exchange. Dynamic structural characterisation was observed using synchrotron SAXS. The lipid formulations used in the dynamic synchrotron study were of similar pH, and the structured lipid particles were on the order of 300 nm in diameter with a moderate size distribution (Table ).