The potential of APBM strategy in improving step economy was further demonstrated (Figure , Panel B). In a previous synthesis of a miR-155 expression modulator (118), a bicyclo[1.1.1]pentyl (BCP) amine intermediate 117 was synthesized using a two-electron approach from BCP ester (119). This prior art required 5 steps to access intermediate 117. In contrast, we demonstrated that by employing the APBM coupling/debenzylation sequence, both the BCP and isopropyl sidechains could be efficiently installed in just 2 steps, resulting in markedly improved overall yield (49% vs. 9%). This showcases the effectiveness of the APBM strategy in streamlining the synthetic route and enhancing overall step economy.