The CAS Content Collection is the largest human-curated collection of published scientific knowledge, used for quantitative analysis of global scientific publications against variables such as time, research area, formulation, application, disease association, and chemical composition. We searched the title, abstract, or CAS-indexed terms using RNA-related keywords and their synonyms to identify relevant published documents. Figure shows trends in the number of publications for specific types of RNA. In the past 25 years, the research areas became more diverse as new types of RNA were discovered, and this is reflected in both journal and patent publications, particularly in the areas of siRNA, miRNA, lncRNA, and CRISPR-related research. CRISPR technology has recently increased rapidly in volume of patent publications, and it accounted for 20% of the RNA-related patent applications in 2020.