In Eq. (1) M denotes the mass of the particle, U the vector of velocities, and F C and F S denote the vectors of conservative and solvent forces respectively. Ideally the solvent forces can be computed explicitly as inter-particle interactions between nanoparticles immersed in a domain of explicit solvent particles. However, this approach would be accompanied by an exponential growth in computational cost with a modest system of dozens of nanoparticles. Hence, it is reasonable to represent solvent effects as a probabilistically averaged pair-wise interaction between the nanoparticles. Such an implicit approach would allow the simulation of large systems (in the order of hundreds of thousands of particles) while maintaining a statistically relevant approximation of solvation. The solvent forces can be computed as a sum of a pair-wise dissipative hydrodynamic interaction with a brownian force which acts to thermostat the system at a specified temperature. The resulting equation can be written as