Moreover, based on Knoop and co-workers, the mechanical properties of 2,5-FDCA polyesters are with a well-defined chemical structure which is a desirable feature e.g. in the pharmaceutical industry. We also confirmed this fact in our previous work where the poly(butylene succinate)based copolyesters obtained with the use of CAL-B were characterized by a more regular structure compared to the materials synthesized using a metal catalyst. Notably, besides succinate-based polyesters , many types of other polymers have been successfully synthesized via CAL-Bcatalyzed polymerization, including polyesters such as 2,5-furandicarboxylic acid-based polyesters, vegetal oil-based polyesters, sugar-based polyesters, and 3,6-dianhydrohexitolbased polyesters. It is also noteworthy that the immobilized form of CAL-B can be conveniently removed from the reaction mixture through filtration, unlike metal catalysts which are prone to strong metal-metal interactions and often remain in the final product, making removal difficult. This makes enzymatic catalysts a more desirable option for resource-efficient and optimized synthesis processes.