In general, doping can introduce various compounding factors that can significantly influence the chemical activity of TMD sheets at the doping sites. This influence arises from a combination of factors, including the valence configuration of the dopants and their covalent radii. These factors can lead to a preference for specific types of orbital hybrids, which, in turn, can either enhance strong bonding interactions with adsorbates or impact adsorption while still promoting a physisorptive mechanism. Moreover, the extent to which the dopant protrudes from or embeds itself beneath the Te layer can play a crucial role. The former can enhance accessibility to the doping site for all molecules, whereas the latter can impose additional structural constraints, potentially leading to selectivity based on the shape of the molecule. Finally, doping can also impact the local availability of electrons on the surface, thereby affecting adsorption of molecules with good acceptor or donor characteristics.