The potential of enhancing SERS via energy confinement by Fano resonance has been previously demonstrated . However, Fano resonance-based SERS applications have largely been limited to twodimensional patterns fabricated by top-down nanofabrication methods with structure sizes of >200 nm and >10 nm gap sizes or DNA origami-supported nanoparticle assemblies . A cost-effective, wet-chemistrybased bottom-up synthesis of plasmonic nanoparticles exhibiting Fano resonance in solution would significantly advance plasmonics and sensing/imaging applications, providing new pathways for tuning and amplifying SERS signals.