MSNs allowed the binding of CS chains forming a dense adsorbed mesh. The resulting material was more sensitive to temperature and gelation occurred at temperature 5 °C lower (from 37 to 32 °C). Similarly, the addition of liposomes to a gel made of CS/β-GP resulted in a comparable shift (from 35 to 33 °C). A decrease in gelation temperature to 30 °C, or slightly below, was induced by liposomes added to 20% poloxamer 407 or 30% PLGA-b-PEG-b-PLGA hydrogels. Importantly, these temperature changes did not affect the usefulness of the formulation, which remained in a liquid state and could be injected at the working temperature of 25°C.