Methodologies calculating volatility were estimated by their vapor pressures (VP), the higher VP, the higher volatility. The EPI (Estimation Programs Interface) Suite™ () was selected for the VP predictions. EPI is an early Windows®-based suite of physical/chemical properties of organic chemicals and their environmental effects estimation programs developed by EPA's and Syracuse Research Corporation.The EPI Suite™ uses single smiles batch inputs (as formated by MolSoft) to run interrelated programs, including the MPBPVPWIN™ subprogam. The MPBPVPWIN™ in combination with other subprograms, calculates melting and boiling points, to predict VP mmHg values at ~ 25 ºC. The high accuracy of their VP predictions was confirmed in 3037 compounds with known VP experimental values. In this work, DWBEL-derived children predicting VP > 0.0001 mmHg were further considered as optimal for mosquito repellents. The filtered children were saved as *.sdf 3D files including their mmff94s+ minimization conformers 37 to preserve their 2D geometries for optimal visualization (split_states PyMol command) and/or to increase accuracy and reproducibility of ADV docking . Other volatibility prediction methodologies such as those recently modified 25 based on SIMPOL.1 28 using empirical group-contribution of individual functional group compositions were also tested, but the accuracy of their VP predictions was not tested.