Micro Emulsion Sonication Method is employed to synthesise Curcumin nanoparticles. Micro Emulsion Sonication Method differs from Micro Emulsion Method as ultrasonic waves are used in the Micro Emulsion Sonication method which provides mechanical energy to break up or disperse the particles which in turn improves the uniformity and reduces the particle size in a micro emulsion. In this method Stearic acid (SA) and Capric Triglycerides (CT) are used as the lipid phase. Non-ionic surfactants like Tween 80 and Pluronic F127 are used to stabilize the emulsion. The method starts by heating Steric acid (SA) and Capric Triglycerides (CT) at 75ºC to ensure that the lipid phase melts completely. This temperature makes sure that lipid remains in a liquid state, which facilitates the subsequent emulsification process. After which distilled water and Non-ionic surfactants like Tween 80 and Pluronic F127 are added in the molten lipid mixture. These surfactants help in stabilizing the emulsion and reducing surface tension, ensuring uniform dispersion of lipids in the aqueous phase. A separate aqueous phase is prepared by heating 1 ml of distilled water and non-ionic surfactants to 75ºC. Premature solidification or phase separation during mixing can be prevented by maintaining both the lipid and aqueous phase at the same temperature. Under continuous stirring the lipid phase containing Curcumin is mixed with aqueous phase. This creates a fine emulsion where the Curcumin is encapsulated within the lipid particles, after which the formed emulsion is quickly added to cold water maintained at 2-4ºC. This rapid cooling induces solidification of lipid particles, which leads to the formation pf nanostructured lipid carriers. Thereafter the solidified emulsion is subjected to High-speed Homogenization at 8000 rpm for 5 minutes. This ensures that the nanoparticles are uniformly sized and well distributed. The final product of this method is a well distributed suspension of Curcumin-loaded nanostructured lipid carriers. Efficient encapsulation of Curcumin with the lipid matrix is ensured by the use of surfactants and controlled emulsification. However, sonication and High-Speed Homogenization requires significant energy inputs, which does not make it suitable for industrial application and mass production, due to its increased production cost . Schematic diagram for preparation of curcumin nanoparticle by Micro Emulsion Method is shown in figure .