For each of the 35 selected targets, the ten most diverse CSMs were determined with MOE's function for the generation of diverse subsets (using MACCS fingerprints in combination with the Tanimoto coefficient). These 350 (35x10) compounds were used as queries for screening with ROCS. Note that the number of unique CSMs is 321 as a minority of the selected CSMs are active on more than one of the selected 35 proteins.