The scale of this quality issue can be exemplified by even just a cursory examination of the 74,355 PubMed IDs retrieved with 'inhibitor' and 'drug" in the title or abstract (i.e. the same query plotted as the grey line in Fig. ). Even without detailed inspection the abstracts are very much a 'mixed bag' in terms of ADEV relevance and potential data value. While these simple queries have selectivity caveats, it was determined that only 504 of the 73.3K were included in the GtoPdb 10,798 selected citations. Another peculiarly credibility gap in the literate on lead compounds is related to the importance of PubChem BioAssay checking (as described below).