Data collection was finalized around June 9, 2020 for the CB8 drugs of abuse challenge and October 14, 2020 for the GDCC sterics and flexibility challenge. Submission deadlines were set for September 15, 2020 and February 21, 2021 (updated from February 4, 2021), respectively. Submissions for CB8-G8, CB8-G9, and TEMOA-G3 were optional since these binding values have been reported in literature.