The raw data files were converted to the mzML format using ProteoWizard msConvert . They were subsequently converted to the effective electrophoretic mobility scale with ROMANCE v2, when applicable. Finally, the peak positions and areas were extracted with Skyline for the targeted analyses on standards, and with Progenesis QI v.2.4 for the untargetd metabolomics data (Nonlinear Dynamics, Newcastle upon Tyne, UK).