In drug discovery projects, identifying compounds containing PAINS is relevant, since these substructures generate false positives on hit identification on high-throughput screening. The workflow shown in Figure employs the RDkit Molecule Catalog filter, which filters molecules through some standard PAINS catalogs such as PAINS filter, the Brenk filter, Glaxo, LINT, ChEMBL filters, among others. The workflow appends the substructures found in a new row (by annotating the name of the PAINS).