Notably, with a relative scaffold diversity equal to 23% both before and after reaction filtering, this filtering step did not drastically alter the scaffold diversity 37 of the designs. In general, no statistically significant decrease in the relative scaffold diversity due to the application of the virtual reaction filter was observed (Wilcoxon test, α = 0.05, Figure ), rendering this method suitable for the design of reaction-focused compound libraries. Whenever the predicted reaction product was compatible with the microfluidics system (i.e., potentially synthesizable following one of the 17 selected reaction schemes), the predicted reactants were automatically retrieved from the Sigma Aldrich catalog extracted from PubChem (2019.02.27). For 67 designs, all of the required reactants were available.