In the following we use DUT-76(Cu) as a model system and propose an experimental methodology for accessing the mechanical stability of the mesoporous MOFs by applying adsorption/desorption stress upon physisorption of hydrocarbons. A physisorption of selected alkanes and alkenes at their standard boiling points in combination with in situ and ex situ PXRD analysis, total scattering and SEM imaging is used for fine tuning of adsorption/desorption stress leading to guest-dependent irreversible contraction of the structure.