We test our meta-MD based approach for finding low-barrier (<30 kcal/mol) reactions for uni-and bimolecular reactions extracted from the barrier dataset developed by Grambow et al. Based on this dataset it should be possible to locate 26 low-barrier unimolecular reactions at the ωB97X-D/def2-TZVP level of theory starting from 163 reactants. Our method uses Grimme's meta-MD approach, with carefully chosen hyperparameters, to identify possible products, which are subsequently screened using semiempirical reaction energies and barrier heights before being refined with DFT (Figure ). The meta-MD simulations identify 25 of the 26 products found by Grambow et al., while the subsequent semiempirical screening eliminates an additional four reactions due to an overestimation of the reaction energies or estimated barrier heights relative to DFT, suggesting that DFT may thus be needed in the screening process. In addition, our approach identifies an additional 36 reactions not found by Grambow et al., 10 of which have barriers <30 kcal/mol. All low-barrier reactions involve new reactants not represented in the low-barrier dataset, which indicates that the reactions in that dataset are likely the ones with the lowest possible barriers for each reactant.