THCV is a homologue of ∆9-THC, with the primary difference located in the alkyl chain on the C5 carbon with an alkyl chain of three carbon lengths rather than a five-carbon length alkyl chain similar to THC. THCV has been explored as an anti-obesity drug in conjunction with metformin for reducing blood sugar set in early stage clinical , as well in murine models, reduced appetite has been shown . HHC (Hexahydrocannabinol) is an analogue of ∆9-THC, the difference lying in the cyclohexene ring being hydrogenated to form the cyclohexyl ring, the lack of the double bond would assume the binding affinity to the cannabinoid receptors to be lessened . HHC is determined to have novel status as a cannabinoid due to its prevalence being found in trace amounts in nature with limited to no data being accounted for. Although the cannabinoid was elucidated and synthesized in the 1940's by Adams, no clinical research or pre-clinical research has been done on the efficacy or effects on HHC. Several safety studies and articles have been written for the safety on consumption and possible SAR for cannabinoid research , aside from the limited studies, nothing has been of status that contributes to the field of cannabinoid chemistry.