with 0.1 the electron density per hydrogenated water molecule, 𝑏 -, 𝑏 . and 𝑏 / the neutron scattering amplitudes of oxygen, hydrogen, and deuterium, respectively, and 𝑑 the deuterium concentration (from 0 to 1, which corresponds to a percentage range of 0% to 100%). It should be noted that this modification does not consider the possible effects of hydrogen -deuterium exchange between the solvent and the solvent-exposed residues of the biomolecule.