The second advantage of this approach lies in the physical-chemical relevance of the chosen parameters. According to the Lorentz-Lorenz equation, molecular density (volume) and polarizability are vital in determining the refractive index. These parameters correspond to DFT_alpha656nm and DFTMD_vol in our descriptors list. Although DFT_alpha656nm was not selected by GPT -4, the DipoleTot, which can serve as a substitute, was chosen. Furthermore, as we expected, DFTMD_vol was set. In addition to these two parameters, GPT-4 also selected descriptors like boiling point and enthalpy of formation, which could be seen as corrective factors. These parameters strongly correlate with the refractive index, and their selection demonstrates the chemically sound judgment made by GPT-4.