Epigenetic drug and probe discovery continue to be relevant for a plethora of potential therapeutic applications, including cancer therapy. Probes for epigenetic targets would be key components to understand epigenome data that can be the basis to develop personalized medicine. Similarly, chemical probes targeting epigenetic processes are fundamental in basic chemical biology associated with epigenetic processes. Computational and experimental screening efforts of chemical libraries have been ongoing to identify potential hits for various epigenetic targets. In addition to the traditional general screening libraries available for high-throughput screening, chemical companies have been assembling libraries focused on epigenetic targets and the chemical structures are available in the public domain.