Metal-organic frameworks (MOFs) possess remarkable porosity and flexibility in design and as such are suitable for many applications. It is often the case that experimental synthesis of a stable MOF is challenging and requires selecting the right precursors, solvents, and modulators, as well as choosing the optimal synthesis and activation conditions. In general, the purification and activation process often face some difficulties due to the potential for structural collapse and loss of crystallinity. Typically, the commonly used techniques for activation include thermal treatment, solvent-exchange (prior to evacuation /evaporation), freeze drying, and supercritical CO2 technique. In addition, there are some methods that are less common such as microwave heating, ultrasound, and ultraviolet-visible (UV-vis) irradiation. The most widely used method amongst all of these techniques is solventexchange, which entails replacing an evacuating solvent with another one that can easily be evacuated and evaporated without incurring permeant damages to the material. As such, it is very crucial to understand the relationship between the properties of MOFs and the structural collapse during solvent removal. Intrinsic structural factors (e.g. type of the metal cation, metal nodes connectivity, metallinker bonds strength, flexibility of the linker, pore size, and framework topology) are believed to have influence on the framework stability. Recently, Nandy et al. conducted a high-throughput computational study to evaluate the stability of MOFs upon solvent removal as well as their thermal stability. They used natural language processing to text mine the activation status and collapse events. Their results showed correlation between geometrical and chemical derived descriptors of the MOFs and the stability. Furthermore, there are few works that relied on the computed mechanical properties to elucidate the collapse events for certain MOFs. In our present work, computational screening was conducted to evaluate the activation status of MOFs with copper paddlewheel metal nodes (the scheme of the work is illustrated in Figure ). Based on our observation, many of the MOFs that have been previously reported to collapse have Cu metal nodes, and as a case study, only those with the Cu paddlewheel type were selected in this work. The structure of this paper is as follow; in the Methods section, we described how the activation data was collected and prepared for the analysis. In the Result and Discussion section, the relationship between the collapse and geometrical/mechanical properties are presented. Also, we identify collapsed MOFs that are predicted to possess good mechanical properties, and the activation process was attempted with improved approach. Finally, we summarize our findings in the Conclusion section.