The calculated ∆H diss (T ) is used to predict the experimental solid solubility in the CombiSolu-Exp database. A RMSE/MAE of 1.49/0.98 log(mol/L) is achieved in case log(S aq,model,298K ) is used to determine log(S X,298K ), and 0.44/0.29 log(mol/L) in case log(S EtOH,exp,298K ) is used. No significant performance improvement is observed compared to Figure where ∆H diss,T ≈ ∆H diss,298K , which confirms that the temperature dependence of the dissolution enthalpy can be safely neglected between 243 and 364K.