For that purpose, the computational efficiency of MBE(2) at the DFT/def2-ma-TZVP level presents a compelling advantage. Such calculations constitute less than 10% of the cost of MBE(2) using def2-ma-QZVP, yet afford interaction energies that differ by ∼ 1 kcal/mol from what is likely the DFT/CBS limit. Even that difference may very well disappear once many-body counterpoise corrections are incorporated. Moreover, the ωB97X-V/def2-ma-TZVP calculations using MBE(2) require only about half the computer time that is required for an unfragmented (full-system) calculation at the minimal-basis HF-3c level. The former do require 2,500-3,200 h of computer time, which is not a trivial investment. However, wall times can be significantly reduced by exploiting the inherent parallelizability of the pairwise MBE(2) approach. For example, the 181L system consists of 2,534 dimers when R cut = 8 Å, and each of these calculations is completely independent of the others. This makes MBE(2)-based DFT/triple-ζ calculations an attractive choice if a realistic value of ∆E int is sought.