In studying TLRs, molecular docking, combined with the investigation of the dynamical stabilities and prediction of the vaccine's ability to stimulate the immune response are the most crucial. The above-mentioned protocol and its variations have been used multiple times for vaccine design. Undoubtedly, vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have received the most attention in recent years . However, studies on other vaccine designs have also been carried out, both before and after the outbreak of COVID-19.