) ≈ -6.3 For most PPCPs, the FAU framework shows the weakest interaction with the PPCPs (see Table , section S5), which can be explained by the large supercages and the low framework density of the framework, leading to less dispersion interaction between the zeolite and the PPCP. To get a comparative picture of the overall trend in interaction energies, all IEs obtained for a given PPCP were referenced to the IEFAU of that PPCP. Figure shows the average relative IEs over all inserted molecules for each framework, as well as the average relative IE for the flexible and the rigid set (determined by the sign of F/R). Also, the absolute number of PPCPs that could be inserted into each framework is shown.