At the core of Quantum Crystallography is the measurement and calculation of charge density, a key quantum mechanical observable . By integrating quantum computations with diffraction data, QCr approaches enable precise determination, and physical interpretation, of the electron density. Modeling the aspherical electron distribution collected from single-crystal XRD experiments through multipolar modeling techniques , such as those based on the Hansen-Coppens formulation , is now possible also at high-pressure conditions thanks to the technological advancements in synchrotron and laser facilities . This modeling can offer deeper insights into the chemical interactions in crystalline materials. Bader's topological analysis, also known as the Quantum Theory of Atoms in Molecules (QTAIM) ), dorbital population analysis , and investigation of electrostatic potentials and non-covalent interactions , are some of the possible analyses that can be performed on an experimental electron densities. Furthermore, some of these QCr techniques also provide the possibility to constrain/restrain theoretical wave-functions with the experimental electron density . Therefore, by bridging the gap between theory and experiment QCr could provide a new promising pathway for the experimental observation of HPEs, and by consequence, for a better understanding of their elusive nature.