Given that our data originates from a sequence of successive time frames along the CG-MD simulations -with a spacing of ∆t=1ns -, we can also extend our analysis to incorporate information about the transitions between the different clusters (see also Computational Methods and the SI for details). By monitoring the state of each monomer in consecutive frames along the trajectory -that is thoroughly sampled thanks to the speed-up provided by the CG scheme -we can extract information on the relative probabilities for a monomer in a certain state (or color) to remain in that state or to transform into a different configuration (i.e., to change color) in the following frame. We can thus introduce the transition probability: