For conducting the review, the research statement was defined and research papers were collected from Google Scholar by filtering the results from 2020 to 2025 to get the most P a g e 6 | 56 recent results . For searching papers, several keywords were used including "pandemics", "Pandemic Vaccines", "Corona Virus Pandemic", "Influenza pandemic", "Role of GPCRs in viral infections", "Role of kinases in viral infections", "Universal pandemic vaccines", "AI in pandemic vaccines", "ML in pandemic vaccines", "Automation in universal pandemic vaccines", "Challenges in pandemic vaccine development", "Need of universal vaccine", "Challenges in universal pandemic vaccine discovery". Afterwards, multiple unique points were collected from each paper and the duplicate points were removed. Furthermore, the unique points left were arranged logically and the results were analyzed and reported. In the last step, the conclusion was drawn and the future outcomes as well as the challenges were reported.