Autonomous self-optimizing flow reactors (ASFRs) represent a promising advancement in high-throughput chemical synthesis, combining principles of automation, artificial intelligence, in-line analytics, and robotics to streamline and accelerate the process of creating molecules. ASTR increases the throughput of experimentations in flow reactions by engaging inline/online analytics, ML-based optimizations and subsequent prediction of the next experimental conditions. The schematic representation of ASTR is given in figure .