To illustrate the potential of the method to indirectly detect the activity of an oxidase through its H2O2 production, we performed the quantitative detection of glucose oxidase (GOD) under the experimental conditions used above. Indeed, in the presence of glucose, GOD catalyzes the oxidation of glucose into gluconolactone with concomitant production of H2O2 from catalytic reduction of dissolved O2. The results gathered in Figure demonstrate the feasibility of the approach, allowing indirect quantification of GOD by autocatalytic molecular amplification down to subpicomolar concentrations.