The second commonly used approach involves the use of error-canceling balanced reactions (EBRs), a broad category of reaction schemes designed to minimize the systematic errors in quantum chemistry calculations. Over the years, many different types of EBRs have been proposed, each with its own set of constraints and assumptions. In this work, we focus specifically on isodesmic reactions (IDRs) and their extensions, a subclass of error-canceling reactions. In the IDRs approach, the species participating in the reaction, other than the target species of interest, are calculated at the same QM level of theory and have precisely known enthalpies of formation, often derived from experimental data.