Among the cell wall polymers, cellulose is observed to have the slowest diffusion (Figure ). The cellulose fibril is on aggregate the largest single entity in the simulation system at approximately 470 kDa. Its size and slow motion made cellulose the natural choice for aligning the overall trajectory prior to measuring the mean squared displacements needed to calculate the diffusion coefficients reported in Figure . Without this realignment, correlated drifts for the center of mass of the whole system pollute the diffusion measurement, substantially accelerating diffusion for the slowest components. The lignin and hemicellulose fractions have similar diffusion profiles, owing to the similar molecular weights for each individual molecule within the system, 4.5kDa for lignin fragments, and 7.1 kDa for each hemicellulose chain. However, size is not the only determinant for diffusion, as hydrophilic hemicelluloses demonstrate slightly larger gains in diffusion coefficient with increasing hydration than amphipathic lignin polymers do. The exception to this is cellulose, which is the largest single polymer component within the cell wall model and was used as the reference to eliminate center of mass drift from the trajectory.