Figure illustrates the tertiary structure of aptamers, which results from the secondary structure's folding. The function of aptamer depends on these three-dimensional structures, which also control how well an aptamer interacts with a protein. Per our forecast, every aptamer possesses a distinct three-dimensional structure, which is evident in how they bind together in docking simulations (explained subsequently). Figure and b displays the clusterin-aptamer docked structures. The figure shows that the clusterin-aptamer interaction happens to the same binding spot predicted by the graph neural network. In addition, we have also obtained the clusterin-aptamer binding interaction using AlphaFold 3, which also shows a similar binding site.