For practitioners, if retaining the actual dynamics is a concern, TIP3P-F can be used only in the equilibration phase to create well-sampled starting points for runs with regular TIP3P. If sampling is the focus, as is usually the case, TIP3P-F can be used also for the production runs. Overall, we recommend TIP3P-F for the efficient sampling of (bio)molecular systems, resulting in a roughly two-fold speed-up in time-to-discovery and, with that, a ∼50% reduction in energy cost and reduced climate impact. Facility for computational resources.