The canonical representation of Ritonavir is, and its width. This is a good example of why localization of small molecule to the protein is more important than a high docking score in realistic molecular design, however both being important. Specificity, however, does usually go with high score. Ritonavir was found in conjunction with Liponavir, and also in other combinations, not to be an effective drug in blocking SARS-Cov-2 .