The enormous enhancement factors accessible for SERS through the combined EM and CM contributions requires the presence of probed molecule at the close proximity to the metallic surface (<3-5 nm) given the rapid decay with distance from the substrate of the LSP field (for EM) and the need to stablish charge-transfer complexes between the analyte and the SERS substrate (for CM). This is particularly challenging for the detection of VOC given their volatile nature and typically low adsorption capacity on metallic surfaces. Fairly recently, a comprehensive review has been published highlighting the main strategies in tackling the issue of delivering of the analyte towards the hotspot generated at the surface of SERS substrates. Along these lines, chemical strategies i.e., grafting of recognition elements that specifically capture analyte at the plasmonic hotspot surface are possible. Following complementary physical strategies, research in engineering of the wettability of the surface for drying the analyzed samples on SERS substrates and the introduction of a porous environment that allows for capturing the target analyte (e.g., from the gas phase) to increase its local concentration within the hotspot decay are pursued. At this point, the versatility of Metal-Organic Frameworks (MOFs) makes them particularly attractive in developing a new generation of SERS substrates.