The increasing interest in the ability to process biomaterials in both melt and solution forms holds significant importance for creating desired shapes and functionalities in the surge of new biodegradable materials. In this regards, succinic acid which can be derived from biomass feedstock is an important monomer for the synthesis of poly(butylene succinate) (PBS), an environmentally friendly aliphatic polyester. PBS is synthesized by polycondensation method using succinic acid or dimethyl succinate (DMS) along with 1,4-butanediol . PBS is an important polymer for advanced manufacturing technologies due to its benefits of low-cost manufacturing, potential for multifunctional applications using PBS-based copolymers, and the possibility of creating completely biodegradable composites with outstanding properties. PBS and PBS-based copolymers show excellent biocompatibility with a variety of animal and human cells relevant to tissue engineering, including rat osteoblast and cardiac cells, mouse fibroblast and myoblast cells, and human fibroblast and chondrocyte cells . While PBS has many attractive properties such as biodegradability, biocompatibility and versatile mechanical properties, and holds a great potential for use in advanced technologies as a green polymer, it does have some limitations.