for structure-based virtual screening. To evaluate the applicability of GGAP-CPI-IntEns and other CPI baselines as SFs, we conducted a comprehensive virtual screening assessment using five well-recognized benchmarks: CASF-2016, MerckFEP, DUD-E, 34 DEKOIS-v2, and LIT-PCBA. We compared GGAP-CPI-IntEns with multiple existing SFs. Among these benchmarks, CASF-2016 and MerckFEP are used to evaluate ranking and scoring power, while LIT-PCBA, DUD-E, and DEKOIS-v2 are used to assess screening power.