To overcome these limitations, scientists aim at enhancing the TA robustness and at developing equilibrium shifting strategies. The first point can be achieved through enzyme immobilization, as the resulting heterogeneous biocatalysts are often more versatile and amenable to more productive flow processes. The second point usually relies on using large amino donor excess or on consuming/removing the (co)product during reaction . Besides the widely reported multi-enzymatic cascade reactions or non-catalytic consecutive reactions that can be used to push the equilibrium of the transamination reaction towards the production of the target amine, one alternative possibility is the physical separation of one of the transamination products towards another phase in the system. For example, in-situ (co)product removal (ISPR) strategies were recently employed in batch with free transaminases to drive the reaction towards the formation of valuable chiral molecules . In these examples, the acetophenone co-product was removed from the aqueous phase reaction medium by liquidliquid extraction (using an organic co-solvent), or the targeted chiral amine was selectively crystallized by salt formation.