The 'None Fuzzy' condition keep most information of a reference shape including its atom type, bond type and bond connection as well as atomic coordinates, while other conditions miss some information on purpose to make a fuzzy reference shape to achieve balanced performance between high shape similarity and low 2D graph similarity. The general compound qualities for generations can be found in Table . 'None Fuzzy' shape condition results in less unique but more valid structures. In contrast, applying less precise (fuzzier) condition leads to more unique but less valid structures. We examine the multiplication of validity and uniqueness as a balanced metric score. Among seven fuzzy levels of shape condition, point cloud level generates the most valid and unique molecules with a value of around 0.57 and the order is 'Point cloud' > 'Mixed point cloud' > 'Fuzzy element and bond' > 'Coloured point cloud' > 'Fuzzy element' > 'Coloured mixed point cloud' > 'None fuzzy'.