Figure shows the distribution of density for the SA score of compounds in LANaPDB and COCONUT (Figure ), fragment libraries (8B), and "Fragments RO3" (8C) for all libraries. The SAscore values for compounds in NP databases are similar (for example, the mean SAscore value for COCONUT is 4.85 and for LANaPDB is 4.53). For both NP databases, 86 percent of the compounds are found with a SA value ≤ 6, meaning that this fraction of structures is easy to synthesize (according to this approximation).