Finally, we evaluated the pharmacokinetics (PK) of SIM1 following intravenous and subcutaneous administration in mice (Fig. ). SIM1 exhibited highly favourable bioavailability and stability, including high AUCs, low clearance and long half-lives, comparing positively to those of the more canonical small-molecule components i.e. monovalent JQ1 and bivalent MZ1 (data available on OpnMe.com) (Fig. and Supplementary Table ). Such favourable PK profile is remarkable given its large size (molecular weight 1,619 Da) and qualifies SIM1 as chemical probe appropriate for in vivo use.