and Au-S6). In the extended panel, some slight differences in the activity patterns of Au1 and Au2 appeared. While Au1 showed high antifungal activity against all fungal strains, Au2 was not active against the C. glabrata and C. tropicalis strains. While the compounds showed only low to no haemolysis they both displayed significant cytotoxicity in the repeated assays. Nevertheless, the observation that small structural alterations seem to significantly alter the activity profile of these compounds encourages further investigations into these molecules.