Both situations reveal that the proteins bind together suitably. Moreover, it was shown to us that the druggable region of the protein had the binding site. Since the druggable region is found in the bottom part of the protein, the receptors must conformationally change their structures to interact with the protein. We speculated that the cause of these interactions was due to the amino acids and the electrostatic charges. CAR T cell enrichment purifies CAR T cells from the normal T cells. Aptamers can also be used for this process. We used eight aptamers (A1-8) that can bind to the γδ TCR receptors and can be used to separate CAR T cells from normal T cells. Therefore, we docked the aptamers on the TCR receptors and computed the TCR-aptamer interactions, as shown in Figure . Aptamers A3, A4, A5, and A7 formed the maximum number of hydrogen bonds. In addition, the binding energies of the three best aptamers were: γδ_ A4: -16.74, γδ_ A5: -18.12, and γδ_ A6: -16.35. Hence, aptamer A5 could be used for the elucidation process.