All authors were then invited by the initiators to contribute to the discussion by providing answers to the questions and also comments to answers over a six-week period, encouraging discussions among the authors. Guidelines were provided to ensure a smooth collaborative process. The end result was an extensive first draft of the manuscript, running over sixty pages and with several hundred references. After a two-week internal review involving all authors, an additional two weeks were allotted for responses to the internal review. The purpose of the internal review was solely to improve clarity of expression -not to restrict in any way the freedom of the authors to express their opinions.