We apply the EMLE implementation described above to calculate the 2D free energy surface (FES) of alanine dipeptide build as an alanine amino acid capped with an acetyl group on the N-terminus and Nmethylamide on the C-terminus (ADP) in explicit water. ADP is treated with a MLP or QM method, and water at the MM level (TIP3P). Various combinations of embedding schemes and in vacuo energy models were used. The results are compared to a reference FES at the DFT QM/MM (ωB97X/6-31G*/TIP3P) level to investigate the importance of different energy components for the accuracy of the resulting ML/MM potential.