The aggregation kinetics were approximated based on the depletion of single chains in so- Fig. 2D histogram of the radius of gyration R g and shape anisotropy κ 2 calculated over 80 independent single-chain simulations of various chain lengths in poor solvent conditions. The distributions were calculated over the period µs, corresponding to the time by which the average aggregate size ⟨N agg (t)⟩ in the poor solvent for both exible and regular backbones was approximately 2 in the multi-chain simulations. The R g is normalised by R g,max , the R g of a fully extended rod, with R 2 g = L 2 /12 and L = 1.4 nm per monomer. Representative conformations are shown near their corresponding peak in the distribution. The colour scale is the same in all cases with darker regions corresponding to higher probability. lution, from which the aggregation time τ c was approximated as the time for the concentration of unaggregated chains in solution to fall to 25% of the original concentration. This proportion corresponded to an average aggregate size of ≈2-2.5 in the simulations in the poor solvent, and so this definition should be representative of the characteristic time scale of multi-chain aggregation. The values of τ c for the multi-chain systems studied are given in Table alongside the time scales of the corresponding single-chain folding. For 20mers of regular backbone flexibility in the poor solvent, the aggregation time scale is almost five times shorter than that for single-chain folding.