An important way to control the relevance of the generated chemical matter is to demonstrate this workflow's ability to reconstruct the ligands from which the reduced set of 624 fragments originate (reduced original ligands): 35 recombined molecules have exact matches and 324 recombined molecules are substructures. Note that only a subset of fragments (624 out of 2,977) was used for recombination, thus only a fraction of original ligands can be retrieved.