In addition, inclusivity is a key element, requiring consideration of a wide panel of patients with varied characteristics such as body weight, bone mineral density and the enzyme/protein content of the biological fluids with which the hybrid hydrogels come into contact. One of the main challenges is to gain access to patient samples and therefore to true biological data, but we believe that such considerations cannot be overlooked to develop effective solutions with clinical success also giving the possibility of incorporating individual patient characteristics and thus paving the way for personalized treatments. Accounting for differences among sexes would be also crucial to achieve optimal treatment outcomes. Finally, when working with patients, ethical concerns related to the potential long-term effects of hybrid hydrogel components in the body naturally arise. How does the hydrogel respond to changes at the diseased site during treatment, such as variations in pH, enzyme content, or cell density and type? Additionally, would the degradation rate exactly match the time of action? What happens after the therapeutic action is complete, but the hybrid hydrogel remains at the administration site? Long-term evaluation considering the life duration of these hydrogels is crucial to ensure the safety of the patients.