There is no published computational or experimental binding data for rutin binding to SARS-CoV-2 helicase, although Huynh et al., amongst several others, reported that MD calculations predicted rutin binding to M pro 53 . Aprepitant, which was predicted by our study to have activity against the helicase, has been shown to be effective in treating severe to critical COVID-19 patients in combination with dexamethasone (clinicaltrials.gov (NCT04468646)) .