To overcome this problem, the use of functionalized precursors can be an appropriate solution. For this reason, fluorographene (FG), a perfluorinated hydrocarbon, took interest in the community due to its reactivity and the possibility to form several graphene derivatives through nucleophilic substitution with high degree of conversion. In this context, coordination chemistry, and reticular design in particular, has given rise to a new route for the functionalization of 2D materials thanks to its greater chemical versatility and tunability, yielding to higher degrees of functionalization, if compared with those achieved in purely inorganic materials. Thus, the interest in finding 2D molecular analogues has increased, as they can be chemically tuned by the proper chemical design. The molecular nature of layered coordination polymers (LCPs) permits, a priori, the incorporation of different functionalization onto the 2D molecular material. This is a common approximation in the field of coordination polymers (CPs), including Metal-Organic Frameworks (MOFs). These are crystalline materials that can be functionalized in a post-synthetic manner in solution. However, the hybrid composition of these coordination compounds allows also to modify the organic linker before the synthesis of the material in order to incorporate a desired functional group, a feature that is impossible, or extremely difficult, to achieve in inorganic materials. In particular, the first example was developed by Yaghi and co-workers using the synthesis of several isoreticular compounds with different functional groups based on the well-known MOF-5. That can be extended for more systems, as is the case of MOF-74, which can be prepared with different functional groups such as CH3 or NH2 by just using a pre-functionalized organic linker. This strategy preserves the crystal structure but modifies the physical properties, as for example the CO2 affinity of the pores.