In spite of increasing understanding on the novel evidence on the lactylation in various cellular components of tumor microenvironment, there is a gap regarding the nature of the enzymes may use lactyl-CoA for lactylation and report of lactyl-CoA in the physiological setting. At the same time, the possibility of the involvement of histone acetyltransferase (HAT) p300 which is well-known as a regulator of chromatin remodeling is indirectly proposed, but not explored .