To prove that our theory of activation-collapse is general to a variety of materials, we further apply these simulations to the full family of IRMOF materials. It is generally accepted that larger pore diameters will lead to less stable frameworks overall. Accordingly, to independently test the effect of 275 pore size and window diameter on solvent activation, we simulated dichloromethane and acetonitrile removal from IRMOFs with a range of linker lengths and sidechain substitution (linkers shown graphically in Figure ) leading to a range of pore and window diameters (Figure ). These quantities have been widely used as metrics to represent pore interconnectivity and size, respectively. Although the bulk surface tension of each solvent is a constant value, Figure shows that ΔU ‡ act varies 280 widely depending on the sorbent material used. Notably, while the relationship between pore diameter and transition energy did not monotonically increase -i.e. values for IRMOF-12 and -14 were lower than their smaller-pore equivalents -the relationship between window diameter and transition energy did. The two aspects of pore geometry are clearly correlated, however transition energy appears to be more strongly related to the window diameter and therefore the interconnectivity of 285 the pores rather than the pore size. Similar trends were observed for both dichloromethane and acetonitrile, indicating that greater pore size and connecting window areas will increase the likelihood of activation-collapse. These findings are also in line with the clustering behaviour of acetonitrile in IRMOF-1 described earlier (Figure , S3, and S5), which shows a tendency to fill an isolated pore before bridging into neighbouring spaces within the MOF. 290