In many practical SARs or SMARts analysis under the chemical space framework, data visualization techniques are used. To this end, several methods have been developed and implemented . In favor of open access tools and democratization of science , there is a need to develop open access tools to automate the generation of visual representations of chemical space and chemical multiverse of compound data sets to contribute to the analysis of SARs or SMARts. This manuscript aims to introduce and describe MAYA: an open-access tool to explore the chemical universe and multiverse of compound data sets annotated with multiple biological endpoints (herein socalled a "chemical megaverse"). The tool is general and can be adapted and extended to include various molecular descriptors (e.g., fingerprints), properties and several calculated scores other than biological activities. The tool can be used in various applications such as multi-target drug design, analysis of on and off-target effects, and analysis of virtual screening results where a given set of compounds are annotated with calculated scores. Herein, we illustrate the application of MAYA to analyze SMARts of an exemplary set of compounds of therapeutic relevance.