The newly designed receptors have the advantages of simplicity, modularity, and synthetic availability: their synthesis involves only two metal-free steps and starts from commercially available and inexpensive reagents. We envision that through modifications of the lower rim substituents, their selectivity can be further tuned to bind anions of various shapes and in a variety of environments. Importantly, the synthetic procedures for such modifications are well established, because resorcin [4]arenes have been extensively used in supramolecular chemistry for many years and lower rim modifications have been utilized to control their solubility. In light of the current findings, lower rim modifications of resorcin [4]arenes can take new directions, and the existing synthetic know-how can result in unusually fast progress in this field.