NMR spectra are complex entities (Figure ) that require a combination of theoretical knowledge, visual recognition, and well-conditioned analytical thinking for interpretation. In fact, the mother of all NMR experiments, i.e., the 1D H NMR (HNMR) experiment, to which novice and experienced users alike are typically exposed from the onset of their studies, embodies a particularly high degree of complexity: the liquid (isotropic) HNMR spectra of most, including very small, molecules in solution give rise to highly convoluted spectra that make decoding the underlying molecular structure a less-than-straightforward exercise.