Supporting Information. Experimental Section and complementary Figures (from S1 to S23) on the (i) influence of pH on the autocatalysis with P2, (ii) UV-vis spectrophometry and HPLC characterization of probes, (iii) kinetic analysis of the H2O2-mediated deprotection of probes, (iv) numerical simulations of the autocatalytic reactions, (v) justification of the rate constants used for the 1,4-NQ autoxidation, (vi) redox cycling experiments with the 1,4-NQ, (vii) influence of the buffer composition and pH on the autocatalysis with P3, (viii) screening of naphthoquinones for their redox cyling properties, and (ix) indirect detection of glucose oxidase. "This material is available free of charge via the Internet at ." a Are highlighted in blue the change made when going step-by-step from the first simulation entry to the last one.