Among the most commonly used nanosensors are temperature, proximity, motion, pressure, light, gas, sound, and humidity sensors. Biological nanosensors are a specialized subcategory of nanosensors that effectively combine biological components with nanoscale materials to detect biomolecules such as nucleic acids, proteins, antibodies, enzymes, biomarkers, entities such as pathogens, etc. allowing monitoring of biological processes. Biological nanosensors are used in medical diagnostics, bioassays, and for monitoring drug delivery and disease progression. The major challenge in developing nanosensors is the requirement of precision that could potentially lead to reproducibility issues and controlling the signal-to-noise ratio.