(ii) All fragments were grouped by and deduplicated within subpockets (excluding pool X), while the number of duplicates was kept per deduplicated fragment: 67% represent singletons (appear only once per subpocket) and 12% originate from different molecules that were bound to the exact same kinase and subpocket. One interpretation of this result can be that 79% of the collected fragments have the potential to be part of a molecule that specifically inhibits one kinase. This is in line with the arguments by Xing et al. and Hu and Bajorath 51 after exploring kinase hinge binding scaffolds. Another interpretation can be that 4 out of 5 fragments have never been explored on kinase targets from a different family.