Finally, we explored the effects of other commonly deployed amine donors on our model reaction (Figure , Smart donors and Other donors). Of cadaverine, putrescine, ethylenediamine, and ortho-xylenediamine (0.028), which have all been leveraged as smart donors, only the latter elicited a reaction, but it proved much less effective than L-Lys (5.9). In the former cases, it is likely that sluggish kinetics stemming from incompatibility with PRO-TRANS(248) prevented the thermodynamic equilibria from being achieved, thus rendering a head-to-head comparison with L-Lys unfeasible. Likewise, IPAm and S-methylbenzylamine (S-MBA) also appeared to be incompatible.