For this study we further refined our search to compounds that showed antifungal activity (i.e. MIC 16 µg/mL or 10 µM) against at least one of the two tested fungal strains. The number of metal complexes fulfilling this criterion was 90 (8.7% of all tested metal compounds). This number was further reduced by including only compounds with 'high' antifungal activity, which was defined as having at least one MIC lower or equal to 2 µg/mL or 1.25 µM. This reduced the dataset to 36 metal complexes. It is worth noting that obtaining 36/1039 (3.5%) compounds with high antifungal activity and non-toxicity from a crowd-sourced screen is a remarkable outcome. For comparison purposes, of the 287,534 small organic molecules for which a MIC was determined through CO-ADD against at least one fungal strain only 3076 (1.1%) were found to be active. About half of these were further classified as toxic, leaving 1586 (0.6%) small organic molecules with activity against fungi and no toxicity at the measured concentrations. Applying the same "high-activity" filter to these compounds leaves 409 highly active non-toxic organic molecules or 0.14% of all compounds tested. Two observations stand out when comparing the data for organic molecules with those for metal complexes. Firstly, the overall antifungal hit-rate for metal complexes is 23 times higher than that for small organic molecules, re-confirming our previous finding that metal compounds have superior hit-rates against microbial organisms (Figure ). The caveat is that the (metal) compounds tested by CO-ADD are not randomly selected: the collaborators submitting some or most of the compounds may have chosen or synthesized them because they expected that they might possess biological activity. When all the compounds displaying cytotoxicity are removed, the metal complexes still show a vastly superior rate of active and non-toxic compounds (8.7% vs 0.6%, Figure ).