OATs plays an important role in maintaining drug concentration in blood by controlling the excretion of drugs outside the body . On the other hand some OATs are involved in the reabsorption of drugs into the bloodstream . Therefore maintaining drug concentration through these receptors is important for ensuring therapeutic efficacy and safety . Recently, two separate studies have elucidated the 3D structure of OAT1 using cryogenic electron microscopy . These structures will be helpful in understanding the OAT1 drug binding and releasing mechanism. This in turn will help in designing drugs that can control the OAT1 functioning and help in controlling the drug concentration in blood. We hypothesize that the OAT1 should have a specific drug binding site where the drug can bind and cease or slower its functioning. Therefore, in the current work, we have used molecular docking simulation technique to find chemical compounds that can bind and potentially inhibit the OAT1. From these simulations we have selected five ligands that strongly binds to the OAT1 receptor. In addition, the pharmaceutical properties of these ligands were also evaluated. Based on the docking score and protein-ligand interactions, top five ligands were selected for further analysis.