Hyponatremia is a condition in which the plasma sodium concentration is less than 130mmol/L. Hyponatremia is manifested by insufficient intake (rarely), excessive loss, and an absolute or relative increase in water. It can be classified into two broad categories of factors: renal and non-renal. Hyponatremia due to renal impairment can occur due to osmotic diuresis, decreased adrenal function, or acute or chronic renal failure. Non-renal factors such as vomiting, diarrhea, intestinal fistula, excessive perspiration, burns, and other disorders all affect the disease process. The LCN type CS-α/β neurotoxic peptides of the Ebola virus proteins controled the Na+ channels in kidney and gastrointestinal cells, and then resulted in hyponatremia.