The 41 selected de novo molecules were synthesized in flow using computationally suggested reactions. Of these compounds, 21 were predicted to be synthesizable by sulfonamide formation, 19 by amide bond formation, and compound 21 by ester bond formation (Table ). On the basis of the respective HPLC-MS mass peaks, a total of 25 compounds were successfully synthesized on the microfluidics platform (1-25, Figure ), corresponding to a 61% success rate.