One cause of the dissatisfying data shortage situation has been the lack of a culture of data deposition and sharing in chemistry in the past, where at least from the early 1990s onwards, with the advent of the internet, widespread data deposition and sharing would have been possible. There have been notable exceptions, such as the crystallography community, that have developed data deposition cultures even earlier. Both small molecules and biomacromolecule structures have been and are being deposited in the Protein Data Bank (PDB) and the Cambridge Crystallographic Database (CCD) . Of particular note, the open PDB in combination with the openly available protein sequence information (for multiple sequence alignments) formed the basis for the outstanding success of the AlphaFold protein 3D structure prediction system . Similarly, open databases such as PubChem , ChEMBL , ChEBI , Drugbank , the Human Metabolome Database (HMDB) , the Collection of Open Natural Products (COCONUT) , the Natural Products Atlas , the Natural Products Magnetic Resonance Database , and ZINC fundamentally broaden the research opportunities . The PubChem database is used by millions of users every month . An example for the usage of the referenced databases is the creation of a classifier that determines whether a Natural Product (NP) originates from funghi, plants, or bacteria based on its chemical structure with data obtained from the COCONUT database . The ZINC database has recently been used for the in silico determination of drug candidates that inhibit the main protease of SARS-CoV-2 .