Covalent integration of the nano-objects in the gel matrix can gradually increase the level of control on the hybrid hydrogel structure. In some examples, nano-objects served as the only crosslinking knots, whereas in others their presence supplemented the covalent/noncovalent crosslinking of the matrix. In both instances, such coupling also prevented the premature leakage of nano-objects from the hydrogels, ensuring the long-term preservation their composition and functionality.