While we are not aware of previous applications to systems employing solid catalysts, we have noted that the use of Supramolecular Protecting Groups to control reactivity is not a new phenomenon (though nomenclature may vary). Since early reports, however, concepts and implementation of catalytic systems for synthesis have developed enormously. Where refining/engineering catalysts (the selectivity and activity of singles species) was long the overarching focus, increasingly catalytic systems are becoming accessible. Whether they employ multiple enzymes in a 'cascade', chemoenzymatic combinations, or the use of multiple chemical catalysts, all these approaches share the division of roles into modules, comprising a (catalytic) system. We suggest that the value of SPGs is not as stand-alone alternatives to 'traditional' selective catalysts, but promising modules incorporation into developing approaches to catalytic systems.