Batch reactions are defined as chemical reaction vessels where there is no flow of the reagents/products in or out of the reaction vessel until a target reaction conversion is obtained. HTE batch platforms leverage on parallelization of experiments to perform several reaction conditions simultaneously in order to increase the experimental throughput. Commonly, batch platforms that include a liquid handling system for setting up reactions based on a plunger pump (e.g. syringe, pipette), a reactor capable of heating and mixing, and inline/online analytical tools. Many HTE batch experiments have been performed in self-contained automated platforms developed by various instrument manufacturers (ChemSpeed, Zinsser Analytics, Metler-Toledo, Tecan, etc.). In these HTE platforms, microtiter well plates (MTP) and reaction blocks containing 96/48/24-well plates are widely used as reaction and characterization vessels . UltraHTE configurations typically incorporate 1536-well plates, enabling the exploration of lager parametric spaces of reaction parameters. While UltraHTE was initially tailored for biological assays, the versatility of these modules has extended to optimizing chemistry-related processes . The Chemspeed SWING robotic system equipped with two fluoropolymers and PFA mat-sealed 96-well metal blocks was used for the exploration of stereoselective Suzuki-Miyaura coupling, offering precise control over both categorical and continuous variables (Figure ) . The integrated robotic system containing a four-needle dispense head facilitated the delivery of reagents in low volumes and slurries, ensuring accuracy and throughout of the process. The entire experimental workflow was further optimized through parallelization, dividing reactions into loops of eight, which enabled them to complete 192 reactions within 24 loops, achieving significant throughput in four days. Other reports for various reactions include the Buchwald-Hartwig amination , Suzuki coupling , N-alkylation , hydroxylation , and photochemical reactions . The adaptability and widespread availability of 96-well plates have facilitated their extensive adoption in optimizing chemical synthesis methodologies. The details of these developments have been reviewed recently .