Equivalent rings are rings of identical size that share at least one bond with a common neighbor ring, and for which all the bonds not contained in the common neighbor ring are the same (e.g.: rings A and A', and B and B', Fig. ). Then, rings between 7-membered and 33-membered are selected for breaking. Rings smaller than 7-membered rings have a small and well-defined set of stable conformations (e.g., boats and chairs) that do not require this method to be sampled. Rings larger than 33-membered rings are theoretically compatible with the method, but were arbitrarily excluded because the torsional complexity of their open forms would exceed the current search capabilities of our docking engines.