Figure (b) shows the number of unique subsystems generated at each n-body order, excluding terms where C i,x = 0 in Eq. ( ). An interesting feature of these data is that the number of three-, four-, and five-body terms actually decreases as n increases. In essence, the combination of higher-order n-body terms with energy screening serves to localize inter-fragment interactions into larger domains (characterized by larger n), which are capable of accounting for all inter-domain interactions. The most dramatic examples of this effect are the fused-cube isomers #1 and #20 (which are provided in the Supplementary Material), for which the addition of a single 8-body fragment to a MBE (7) scheme reduces the number of subsystems by ≈ 200 for either cluster.