Two of the non-ranked methods do not allow for straightforward sensitivity analysis based on a single factor, because only a single version was submitted (FSDAM/GAFF2/OPC3 and reference calculation DOCKING/GAFF/YANK). Both of these methods were also used for TrimerTrip and the cyclodextrin challenge. The error metrics for both of the methods were relatively similar, although the DOCKING/GAFF/YANK method performed slightly better by a number of metrics. However, the ME for FS-DAM/GAFF2/OPC3 is quite low -less than 1 kcal/mol -because the method tends to predict binding free energies for OctaAcids with guests bearing a carboxylate group which are too favorable, and too unfavorable for guests with cationic ammoniums. In comparison, DOCKING/GAFF/YANK errs for all guests with carboxylate group are too favorable. Still, enough things differ between these two submissions that it is difficult to attribute performance differences to any particular source. Such simple variations provide the greatest opportunity for the community to learn.