As pointed out by Cieplinski et al. docking scores may also be used as a challenging test for generative models that "reflect the complexity of real discovery problems". Our study suggests that finding synthetically accessible molecules with good docking scores for CM presents an especially challenging objective function, and more so if the SP docking score is used. However, a benchmark based on a commercial software package such as Glide is not ideal and it remains to be seen whether this target is equally challenging using open source docking software such as SMINA.