The armored DNA condensates with the 3D DNA origami showed size-selective molecular semipermeability of their surface. The semipermeability could be changed between coated and armored DNA condensates. Although the coated and armored DNA condensates had almost the same appearance in the CLSM images, they had different surface properties, suggesting that the fusion behavior and permeability can be dynamically controlled by adding the connector by changing the state from the coated to the armored DNA condensates. Some armored DNA condensates attached to one another, forming multicellular structures of DNA condensates (Figures and). The armored DNA condensates had permeability of small molecules and impermeability of biomolecules like ssDNA. Those properties will contribute to multicellular DNA condensates with small molecular interactions while keeping biomolecules inside. Therefore, the armored DNA condensates would have advantages for artificial cell construction because of their stability against fusion, the selective permeability of small molecules while maintaining compartmentalized spaces, and their multicellular formation ability.