The NP-likeness profile of the ten individual compound databases in LANaPDB and the entire collection was compared to the profile of COCONUT, one of the largest collections of NPs in the public domain. A set of drugs approved for clinical use was also used as a reference. The same curation process described above was applied to the two reference databases. Table summarizes the data sets analyzed in this work. A database aimed to gather and standardize the natural product databases of Latin America. Composed of 13,578 natural products isolated and characterized in Latin America.