Noviose is a natural yet rare 5,5-gem-dimethyl-deoxyhexose which was initially discovered as a structural constituent of the aminocoumarin antibiotic novobiocin. Structural analogues have since been identified as carbohydrate moieties in other biologically active natural product antibiotics such as the aminocoumarins (ʟ-noviosyl analogues), and fidaxomicin (ᴅ-noviosyl analogues). The noviose-derived moiety plays a pivotal role in the binding of these glycosylated natural products to their respective targets. Structural analogues lacking this carbohydrate unit displayed significantly decreased biological activity. Starting with the first total synthesis of L-noviose by Kiss and Spiegelberg in 1964, numerous other syntheses of D-12-14 and L-noviose derivatives, including stereoselective , as well as enantiodivergent approaches have been reported in the literature.