We utilise the pH robot to titrate a large range of samples, and we present illustrative examples and evaluate the efficiency of the titration algorithm. Finally, we demonstrate the method is generalisable to volumes closer to industrial formulation development tasks. . The X-Z-translating probe head (inset, magnified) incorporates a high-torque mechanical stirrer (3), (4) a slim profile pH probe and (5) two dispensing syringe needles for the acid and base. The needles are coupled to syringe pumps . The entire assembly is controlled in a Python IDE via serial communication to achieve self-driving capability. b) A "physics-informed" machine learning (ML) method is used to drive closed-loop optimisation towards the target pH (red dashed line). c) The speciation diagram, here modelled for citric acid (A = C6H5O7), is used to calculate the effective strength of the acid added.