The range of the NP class probability is from zero to one: one represents a probability of 100% of a compound to be a NP and zero represents a probability of 0% to be a NP. The SMs have values of zero or close to zero. Fig. shows that the LANaPDB compounds have a NP class probability of one or very near to one. Therefore, according to NP-Scout, the probability of the LANaPDB compounds to be labeled as NPs is very close to 100%. In the approved drugs set, 56.5% of the compounds have a NP-class probability between 0 and 0.5 and 43.5% among 0.51 and 1. Therefore, 56.5% of the compounds have a high probability of being SMs and 43.5% a high probability of being NPs. In the approved drugs, the prevalence of SMs over NPs aligns with the findings of the NP-likeness calculator, which indicates that SMs have a higher proportion than NPs. The above is evident in the Fig. , the highest peak is around zero and the peak around one is shorter. According to the NP class probabilities of the individual Latin American countries (Fig. . B and B1) the values are around one in every country. Thus, in all the Latin American countries the compounds have a probability of 100% or near to 100%, to be labeled as NPs.