General amide bond synthesis procedure (compounds 1-15, 22). Solutions (0.2 M) of the respective acid chloride building block in THF and the amine building block in MeCN/DMF (9:1 v/v) were prepared, and 1 ml of each solution was loaded into individual wells of a 96-well plate. For automated synthesis, 0.75 ml of each building block solution was used per reaction and diluted with the running solvent (MeCN/THF, 50:50 v/v) to a total volume of 1.0 ml. The residence time was set to 15 min and the temperature to 55 °C. After mixing both solutions in the reaction chip, the reaction mixture was pumped through the coil and 2 ml per sample was collected in another 96-well plate.