Emerging classes of 2D materials yield a variety of new scientific discoveries and vast possible new applications. These findings rely on developing new synthesis strategies for 2D materials. Approaches such as mechanical exfoliation, chemical vapor deposition and many more have been successfully implemented in a wide range of scientific communities. These synthesis strategies mostly work for vdW materials. However, non-vdW materials with no obvious layered structure are yet vastly unexplored despite the high importance of their bulk form in existing industrial applications. Current synthesis methods of 2D non-vdW materials have limits owing to their complicated process, including high temperature, high pressure, hazard chemical reactions and low efficiency of the synthesis. Often, the resulting material obtain thickness of several nm and synthesis strategies achieving monolayer or (sub-) unit cell thickness are extremely rare. Moreover, top-down methods like exfoliation face challenges in yielding (sub)-unit cell thick materials due to strong chemical bonds that are tough to break relying on cleavable crystallographic directions . These limits the number of available non-vdW materials and inhibits the widespread investigations of its possible applications and scientific phenomena. Thus, straightforward and effective bottom-up strategies to obtain non-vdW materials with (sub-) unit cell thickness are highly desirable. A possible route to create 2D non-vdW materials via the bottom up approach is utilizing 2D space confinement in the synthesis process. For example, a combined method of chemical vapor deposition (CVD) and thermal diffusion results in single layers of Au, Ag, and Ga within SiC and epitaxial graphene. The obtained metals with reduced dimensionality show unprecedented properties, such as semiconducting Au and superconducting 2D Ga. Another approach to utilize space confinement is to chemically fabricate 2D salts within the interlayer network of a stacked vdW material, such as graphene oxide. With that, a new stable 2D form of cuprous iodide (CuI) was found. These studies show that confinement within 2D layers can promote the growth of 2D non-vdW materials. Moreover, reported high pressure values within graphene nanocapillaries and computational studies suggesting unusual behaviour of water under such confinement make graphene nanocapillaries an intriguing vessel for new synthesis routines. It is thus highly desirable to extend angstrom-confined synthesis strategies to transform conventional non-vdW materials, such as TMO, into 2D form. This will enable us to explore unexpected properties of these 2D non-vdW materials. A classic bottom-up technique to grow thin non-vdW materials is electrochemical synthesis. However, it is yet illusive to limit the thickness of the grown material to (sub-) unit cell thickness. In this case, space confinement might help to solve the issue. Early trials with electrochemical growth of Pd into graphene layers yielded promising results with thin Pd sheets of ~5 nm thickness. It is thus compelling to wonder which thickness can be achieved in bottom-up electrochemical synthesis of 2D non-vdW materials via space confinement.