Although much of these findings are in support of Li et al. 2024, one discrepancy is that 1 was determined to be relatively inactive under our conditions but was previously shown perform Ndh2 mediated EET in the iron(III) oxide nanoparticle assay. The driving factor behind this discrepancy is unknown but we hypothesize this could be a result of stability of 1, where degradation products are more active than 1. Although stable in powder, 1 has shown to be inherently unstable in solution and likely degraded during the 24 h timescale of the previous iron(III) oxide nanoparticle reduction assay. Evaluation of the stability of 1 under iron(III) oxide nanoparticle assay conditions confirmed stability issues, while 94.5 ± 3.8% of 1 is remaining at 3 h, only 26 ± 4.2% is remaining at 24 h (Fig. ), with numerous more polar metabolites detected by HPLC (Fig. and). Based on the data presented here, metabolites of 1 that are more polar would be expected to show higher EET activity, aligned with what was previously observed.