With no proven medicine or vaccine to treat or eradicate COVID-19 pandemic, repurposing the existing drugs are promising alternative. Currently, there are multiple clinically proven FDA approved drugs are in preclinical studies or various phases of clinical trials. These include but not limited to CQ (anti-malarial), HCQ (anti-malarial), azithromycin (antibiotic), remedisivir (antiviral), lopinavir (anti-viral), ritonavir (anti-viral), etc (Figure ).In this context, HCQ got immediate stardom in mid-March when US President Donald Trump labeled it as a game-changer for the COVID-19 treatment. Whatever it takes, HCQ holds a special position owing to its dual role as prophylactics and therapeutics. Based on the limited clinical study, on 28 March 2020, the US-FDA issued an Emergency Use Authorization (EUA) for chloroquine phosphate and hydroxychloroquine sulfate for the COVID-19 treatment (Figure ). 46 This inspired the different organizations to start further study and clinical trials in order to validate or establish HCQ (alone or in combination) to combat COVID-19. , , (see the ESI for the detailed summary of various trials done for HCQ). In this context, the recent study using SARS-CoV-2-infected Vero cells and physiologically based pharmacokinetic In India, the Indian Council of Medical Research (ICMR) also recommended the use of HCQ for prophylaxis of all healthcare personnel engaged in the treatment of suspected or confirmed COVID-19 cases with a dose of 400 mg twice daily on day1 followed by 400 mg once weekly for the next 7 weeks to be taken with meals. Meanwhile, various national and international agencies are constantly updating treatment guidelines using HCQ for COVID-19 infection while others are working on drug delivery aspects of HCQ. In this direction, Manning, and co-workers published the future possibilities of HCQ delivery via vaporization to have a direct therapeutic effect with site-specific action using the nasal route. Interestingly, the aerosol component consisted of the ingredients having either mild to prominent anti-viral or disinfectant property.