The success of natural compartmentalized enzyme cascades has inspired the development of biomimetic systems, with multiple groups having employed well-defined spatial organization at the nanoand microscopic levels to construct in vitro biocatalytic cascades with enhanced catalytic performance. For example, encapsulating NiFe hydrogenase in virus capsids improved its thermal stability as well as enhanced the rate of H2 production. Confining the β-galactose, glucose oxidase, and horseradish peroxidase cascade in metal-organic frameworks led to an enhancement of reaction yield in comparison to a freely diffusing analogue. Following the wealth of literature in biocompartmentalization, the organometallic community has since made great strides in confining transition metal based catalysts.