providing computer facilities and support within computational grant no. PLG/2023/016519 and PLG/2024/017332. This material is based on work supported by the National Science Foundation under grant no. CHE-2152521 (A.L.F.). A.B.P. and L.M.S. thank CECAM for financially supporting the organization of the workshop "Leveraging Machine Learning for Sampling Rare Events in Biomolecular Systems", where the discussions leading to this work began.