OpenEye AM1-BCC ELF10 nominally produces charges with the least conformer-dependence among available AM1-BCC methods. To investigate how much OpenEye AM1-BCC ELF10 in calculated AHFE, we chose 6 of the 15 molecules in section 2.6.2 to study further. We generated 5 sets of OpenEye AM1-BCC ELF10 partial charges and run 5-peats of AHFE calculations where the only di erence between repeats is the set of partial charges used for 6 molecules. We compare these results to the AHFE calculations we ran in Section 3.3.