The tables clearly show the different efforts put into the recapitulation of the physiological conditions in terms of biological components and mechanical stimuli, compared to the recreation of a relevant model of the native basement membrane. Indeed, despite the great advancement in OOC technologies with new materials, better actuators and sensors, and a rapidly expanding library of different organs on a chip, the advance in the development of biomimetic porous membranes is very slow. The main limitations that need to be addressed for the creation of more physiologically relevant membrane models are: