For this study, we hypothesize that plasma-laden uremic toxins in the average concentration found for end-stage kidney disease (ESKD) patients alter the adsorption of plasma proteins and the clot kinetics experienced in the presence of PCL fiber membranes. Electrospun PCL fiber membranes are mechanically strong, highly porous, and optically transparent. The transparency and high porosity are achieved by manipulating the electric charge using an aluminum square mesh during the electrospinning process. Plasma was doped to contain 25 uremic toxins with a final concentration similar to that found in ESKD patients (Table ).