In 2019 we reported on an improved variation of the closure potential that uses pseudo-atoms to preserve the valence angles and chirality of the input molecule. Thus, the attraction between the previously bonded atoms can now be described as anisotropic, resulting in more accurate geometries. We employed this method in the D3R Grand Challenge 4, using AutoDock-GPU, achieving RMSDs below 2 Å for all of the 19 macrocycles using visual inspection to select the best pose. The improved method was based on the Smallest Set of Smallest Rings (SSSR) perception algorithm available in OpenBabel.