It is typical to uniformly allocate computational resources by simulating each λ-window for the same amount of simulation time; however, there is no theoretical basis for this practice. For instance, it is unlikely that simulation times necessary for convergence would be equivalent between different systems, such as the protein-ligand complex and the solvated ligand, even if we restrict our analysis to states with identical λ-values. One would expect this likelihood to decline further when considering different ligands or even different protein systems.