The MHC class II transactivator CIITA induces cell resistance to the Ebola virus and SARS-like coronavirus . However, the apparent CD4 conserved residues at the RBD-S1 site of SARS-COV-2 interrupt the CD4-MHC-II interaction for adaptive immune activation . The immunity of CD8+ T cells to SARS-COV-2 is related to the severity of COVID-19 and virus control. SARS-COV-2 evades CD8+ T cell surveillance by mutation of the MHC-I restricted epitope of CD8 + T cells . Mutant peptides exhibit reduced or abolished MHC-I binding, which is related to the loss of recognition and functional response of CD8 + T cells isolated from HLA-matched COVID-19 patients. However, the proportion of IFN-γ-producing cells in SARS-COV-2 specific CD8 + T cells expressing PD-1 is higher than that of PD-1 cells in multimer+ cells. The SARS-COV-2 specific CD8 + T cells expressing PD-1 are not exhausted and function normally . It meant SARS-COV-2 had evolved an MHC-like structure that could bind to the MHC receptor of immune cells. Immune cells that could not attach to the MHC-like form of the virus had survived. Some viruses have acquired inhibitors that target the MHC class I antigen presentation pathway . The cytomegalovirus (CMV) and herpes family encode a series of key molecules required for a targeted immune response . All aspects of acute and chronic CMV disease may be controlled by antibodies, NK, and other cells of the innate immune system, as well as CD8 + T and CD4 + T cell . About half of the identified genes in cytomegalovirus and beta herpes virus have HCMV homologs . The m144 and m145 gene families of cytomegalovirus (m17, m145 to m158) , m157 , UL37 are all MHC-I-like molecules. The Ly49H NK cell activation receptor recognizes m157 . Ly49 receptor binds m157 glycoprotein encoded by mouse CMV (MCMV) . Human CMV(HCMV) UL18 binds inhibitory leukocyte immunoglobulin -like receptor R-1 . Human cytomegalovirus express and distribute a complete library of immune evasion factors for a single MHC class I target . Human cytomegalovirus encodes glycoproteins homologous to MHC class I . The MHC class I homologs encoded by human cytomegalovirus binds to endogenous peptides .