Hydrogels that can be formed in situ under physiological conditions (i.e., in vivo gelation) are of interest for diverse biomedical applications, including in drug delivery, tissue engineering and regenerative medicine. As the results presented herein demonstrate that TiTannic gels are suitable for in vivo gelation, we hypothesized that they may be of interest for drug delivery applications. To test this, we compared the in vitro drug loading and release properties of TiTannic gels to Pluronic F127 hydrogels. Pluronic F127 gels are currently being explored as an in situ gelation system to treat otitis media (ear infection). In the current study, we loaded Pluronic F127 gels and TiTannic gels with the corticosteroid dexamethasone, and measured drug release using liquid chromatography (Figure ).