We report the cluster formation potential of iodine oxyacid clusters, oxyacid-assisted iodine oxide, and iodine oxyacid-amine nucleation assisted by common atmospheric nucleation precursors at 263.15 K in Figure and 283.15 K in Figure . Pure iodine oxyacid-amine nucleation is compared with pure sulfuric acid-amine nucleation in Figure . Thermochemical data can be found in Table in the SI, and in the atmospheric cluster database (ACDB). As discussed in the computational details, our threshold for significant nucleation is 1 cm -3 s -1 , however, due to the limitation of our system size, we would need to observe a formation potential of at least one order of magnitude higher to be sure that the nucleation rate is significant.