Being limited to annotated data from ChEMBL and a small subset of manually annotated assays, we could not assess the validity of the majority of found clusters. From the clusters we were able to validate, we concluded that similar assays indeed grouped together, yet also contained some datapoints where clustering could be further improved. Moreover, in some cases different clusters actually described the same assay, as shown by the completeness score. This was especially true for binding assays, while the resulting readouts are expected to be similar. Part of this over-segmentation could be caused by receptor classes and specific radioligands mentioned in a lot of the assay descriptions. In order to prevent this additional separation based on protein specific information, words referring to such information could be ignored or replaced by a generic abstract term. Ideally, increased awareness of the assay context would help establish validated, standardized ways to deal with this assay context.