Easy customization of force field terms and parameters is typically a challenge for molecular simulation packages. Because SBM is an ongoing practical and meaningful research methodology, it would greatly benefit from a fast, accessible, flexible, and easy-to-set-up implementation that facilitates simulation and force field experimentation. To this end, we have developed SBMOpenMM, a Python library, to set up custom SBMs using the OpenMM toolkit framework for MD simulations. The Python code is flexible, user-friendly, and profits from the high customizability and performance provided by the OpenMM platform. We hope this will foster further research in the field in an open-source collaborative manner.