Herein, we present a model that originates from a distinct foundation and goes significantly beyond the scope of existing frameworks. In this study (Figure ), we derive a non-linear equation grounded in the principle of microscopic reversibility, with minimal assumptions, which captures (or "arrives at", given its deductive nature) all these essential physical features: reaction asymmetry, reactant preorganisation, product reorganisation, the sensitivity of kinetic-thermodynamic response at each thermodynamic driving force. In comparison to G0 ‡ and α that represent the local thermodynamic-independent properties of a family of reactions, we introduce a new set of thermodynamicindependent parameters overarching the global thermodynamic range. Each parameter has a distinct physical interpretation, grounded in common chemical meaning (in contrast to statistical in nature). We demonstrate the applicability of this equation through diverse chemical reactions, illustrating its capacity to describe non-linearities, identify valid linear approximations, and elucidate the role of each thermodynamic-independent parameter. Experimental observations show that some families of reactions exhibit high sensitivity to rate-driving force responsiveness, while others display relatively insensitive correlations. 13 Some sets of reactions exhibit crossing behaviour: one is more reactive in the endergonic region, while the other is more favoured in the exergonic region of thermodynamic driving forces. These distinctions raise practical questions: What should we do to accelerate a given reaction? To what extent will making a reaction more thermodynamically downhill improve its rate? Our derived equation also provides a lens through which to examine these questions.