In the CNEO framework, stationary geometries and reaction paths are obtained on temperatureindependent, ZPE-inclusive effective PESs. As such, searches can still be carried out at each temperature to find the maximum generalized free energy of activation along the MEP, and this is called CNEO-CVT. We will see below, for two reactions, that CNEO-CVT does not offer a significant improvement over CNEO-TST. This can be a third important advantage of CNEO-TST. With CTST, the Minnesota functional MN15 CNEO-CVT yields very similar results to CNEO-TST (Figure ) for this reaction. This can be rationalized from the finding that the CNEO-CVT-MN15 transition state is close to the maximum of the CNEO-MN15 effective PES along the MEP, even at a temperature as high as 500 K (see Figure .) In contrast, there is a significant difference between the transition state locations in CTST and CVT, resulting in large differences in the predicted rates. This contrast is found because CNEO-TST calculates the flux through a transition state that has a maximum sum of the electronic energy and the nuclear zero-point energy.