To further evaluate the potential of these metal complexes, we obtained fresh samples for 21 of the compounds that displayed high antifungal activity and carried out more indepth studies of their antifungal potential against a panel of 8 relevant fungi. We found that the high activity observed in the initial assay against C. albicans and C. neoformans generally translated to high activity against the broader panel. On the other hand, we also studied the potential cytotoxicity and haemolysis of these compounds at higher concentrations and found that in several cases some toxicity or haemolysis was observed. Wishing to understand the potential toxicity of metal compounds, which have been tested in living systems far less often than organic drug candidates, we assessed eleven of these active metal complexes in a G. mellonella larvae toxicity model. Ten out of eleven complexes tested exhibited no toxicity at the highest injected concentration.