Further work can be also be done on generalizing Molecular Darting, as well as improving the move proposals to target favorable orientations of the ligand. One aspect of MolDarting to improve would be allowing regions of arbitrary sizes. While our original implementation of MolDarting only handles regions of the same size, different sized regions can be used instead if they are factored into the acceptance criterion. Similarly, instead of uniform sampling the dihedral regions, we could sample using a Gaussian distribution centered at the maximum of the dihedral, which would favor lower energy conformations of the ligand and thus potentially yield higher acceptance.