Figure shows the obtained optimal conditions for the parameter pair flow rate f tot volume fraction θ water . A set of solutions of 23 data points is identified. In this case, most datapoints fall nicely on a curve, which can be fitted to express the coupled pair of parameters. Practically each datapoint depicts here a successful experiment. Nonetheless, this Pareto front allows now to identify not only optimal synthesis conditions, but to also take economic considerations into account. In principle, high water content is desirable for an optimal synthesis, as typically organic solvent residues need to be removed after synthesis. Further, high flow rates are desirable, as such conditions will facilitate a higher space time yield for the reaction. Hence, a volume fraction of θ water ≈ 83 % and maximum flow rate of f tot = 8 mL/min would represent the most ideal condition for the experiments. A slightly more complex picture is obtained for the Pareto front shown in Figure . In there, the water content was kept constant at 84%, and the polymer concentration was left variable together with the total flow rate. Again, all individual optimizations had a target of 200 nm. In this case, unsurprisingly coming from the complex concentration dependency indicate in the discussion above, a much more diverse field of optimal conditions is identified, and a clear common line is not seen, in this case. While many solutions to the optimization thus exist, nonetheless, a boundary condition can be determined, as indicated again by the red line in the plot. Above this line, successful optimizations are possible, while below no optimization can be successful. It hence presents a Pareto front for the lowest possible polymer concentration for successful optimizations. The line as shown was based on the data depicted as open circles. To confirm the validity of the determined front, we then programmed the automated particle synthesizer to carry out two further experiments, in which two randomly selected points on the line (blue squares) were selected. Indeed, these conditions directly yielded particles of the desired size of 200nm, showing that the line was drawn correctly in all likelihood. Thus, from the combination of Figure and Figure , it can be concluded, that next to a high flow rate and a water content of about 83-84%, a high polymer concentration is most desirable (note that the upper boundary in the experiments was set to 5mg/mL, hence no higher concentrations were tested, and a upper concentration limit pareto front could not be determined), and will yield the desired particle size in the highest yield possible. The exact polymer concentration is in such case determined by the homogeneity of the obtained particle solution, as at a certain polymer content mixtures will lead to blockages in the reactor.