The abaucin-targeted Lol protein complexes are among the under explored bacterial targets that may be an appropriated source for new antibacterial treatments. In Gram negative bacteria such as A. baumannii or E.coli, Lol proteins transport signaled lipoproteins from their internal to their external outer compact membranes. External outer bacterial membrane lipoproteins cause most of their resistance to penetration of antibiotics. Mislocalization of the Lol protein complexes results in bacterial death. Small-molecule inhibitors of lipoprotein transport have shown antibacterial activities. However, most of present Loltargeted antibiotics, including abaucin are active against A. baumannii at low micromolar ranges . There may be room for affinity improvements.