Recently, chiral POPs, including chiral covalent organic frameworks (COFs), have gained increasing attentions due to their unique application in enantioselective sensing, enantio-separation and asymmetric organocatalysis . Based on the chiral building blocks with defined point, axis, planar or propeller chirality, 2D chiral porous sheet or 3D chiral porous skeletons are feasibly constructed from irreversible or dynamic covalent chemistry. In the highly crystalline chiral COFs, chiral channels or voids with well-defined chiral chemical environment can be feasibly obtained. However, the structures for chiral cavities in amorphous chiral POPs are usually elusive owing to the lack of long-range order. To introduce precisely defined chiral voids into the amorphous chiral POPs, chiral macrocycles with rigid chiral cavities are promising building blocks, in which the intrinsic chiral voids of macrocyclic compounds can be well retained in chiral macrocyclic POPs. The chiral macrocyclic monomers can correspondingly provide precise bind-ing sites for small guests, and establish functions for further applications.