in Cu-mediated 18 F fluorination allowed a reduction of the reaction time from 20 min to 5 min and an increase of the apparent molar activity by a factor of 2 for [ 18 F]1c. To the best of our knowledge, there is only one previous report on the use of boroxins for 18 F labeling . More detailed studies on the use of boroxins for Cu-mediated 18 F fluorination with optimization of reaction conditions are currently being undertaken and were beyond the scope of this work.