In this present study, we found that many proteins of the SARS-COV-2 virus have MHC-like structures recognized by MHC receptors. CD4 or CD8 co-receptors expressed by T cells can bind to part of MHC proteins . The inhibitory receptors of NK cells can also bind to the MHC-1 receptor recognition structure. Therefore, the S protein of the SARS-COV-2 virus could bind to CD4 + T, CD8 + T, and NK cells through MHC-like structures. Then the ROS generated by the E protein destroyed these immune cells , resulting in a decrease in lymphocytes. The genetic variation of HLA may produce MHC molecules that could not bind to the viral MHC-like structure. It was helpful for immune cells to evade the attachment and positioning of SARS-COV-2 MHC-like proteins. In this situation, the antigen presentation response would not be disturbed, and immune cells (such as CD4 + T, CD8 + T, NK cells) would be protected from the virus's ROS damage.