This expression provides a unique reduced mass value for any CV of the type given in Eq. 7. In the standard MTD simulation, the user defines the CV, the width of the Gaussian bias potential, and the height of this potential. However, in this formulation, based on the quantum potential, the user needs to provide a definition of the CV and the width of the bias potential σ to define the MTD simulation because the reduced mass µ q and the bias energy are computed automatically with Eqs. 8 and 5, respectively.