The modular nature of this technology opens exciting possibilities for future applications. By demonstrating that small molecules can be potent effectors of ASO cellular compartmentalization and thus, functionality, we pave the way for the development of advanced therapeutic strategies through small molecule conjugation. The integration of small molecules to manipulate cellular environments and target sites offers promising approach to enhance therapeutic outcomes. Our work aligns with the burgeoning field of bi-functional molecules, which combines distinct functionalities into a single entity. This intersection with bi-functional technologies allows our approach to be integrated into the broader context of therapeutic innovation, by leveraging the synergies between small-molecule ligands and nucleic acid-based therapeutics.