The main challenge in the design of CH-bonding anion receptors stems from the fact that the interaction of a single uncharged CH group with an anion is weak. Auspiciously, CH groups are highly abundant and congested in the skeletons of organic molecules, which enables chelate/multivalency effects to enhance binding. Even with these advantages additional polarization of C-H bonds by several strongly electron-withdrawing groups (EWGs), as well as strict elimination of electron-donating groups (EDGs), is considered a prerequisite for any relevant CHanion binding affinity. Using the principle of enhanced polarization, a range of CH-based anion receptors were recently obtained. Some of them, e.g. I-V (Fig. ), exhibited remarkably high affinity, while others demonstrated the ability to operate in an aqueous environment and/or unique transport properties. In this work, we demonstrate a novel and nonintuitive strategy for the construction of CH-bonding anion receptors that relies on a combination of electron-donating and electron-withdrawing groups and leads to the inversion of binding preferences. More specifically, we show that resorcinarenes, which are easily available macrocycles and are well established as cation receptors, can be converted into remarkably efficient anion receptors by a simple substitution. This substitution, together with favorable geometrical features of resorcinarenes, generates a large dipole moment, which is crucial to the concentration of electrostatic potential in a single binding site. Furthermore, we show that the seemingly trivial alkyl chain substitution around the anion binding site endows the receptors with remarkable water resistance and enables highly efficient anion transport across lipid bilayers.