For alanine dipeptide, free energy plots as a function of the Ramachandran angles are depicted in panels A and D of Figure , comparing both water models. Alongside the Ramachandran maps, the marginal cumulative distribution functions of each dihedral (panels B and C in Figure ) demonstrate that changes in the water mass have a negligible effect on the final equilibrium distribution. Furthermore, the dihedral angle order parameters, S 2 D (see Supplementary Information for a definition), for both Ramachandran angles reported in Table , are in good agreement.