As illustrated in Figure , the solvation energies for our molecules follow, generally, a single-modal distribution. The notable exception is water, which features multiple peaks near -10, -5 and 0 kcal/mol. The standard deviation in the solvation energy is approximately 2.8 kcal/mol for all solvents except water, which shows a wider distribution with standard deviation of 4.3 kcal/mol. Some molecules have solvation energies substantially higher or lower than most in the dataset. The solvation energies for these molecules can range from as low as -84 kcal/mol to as high as 5 kcal/mol. For example, there are 543 (0.4%) and 428 (0.3%) molecules with solvation energies below -20 kcal/mol in water and acetone, respectively.