Moving to more experimentally relevant conditions, we examined these reactions in fluorobenzene medium to match the ESI-MS monitoring experiments. For the most favorable ionization sites, we calculated both electronic (Ei) and quasiharmonic Gibbs energy changes (ΔGi-qh-tr) with results compiled in Table S-3. In contrast to the uniformly high, positive gas-phase energies, these solution-phase energies approach zero or become negative. These calculations consider fully separated ions; the effects of ion-pairing are addressed separately below.