Molecular dynamics (MD) has become a cornerstone tool in the study of complex molecular systems, providing high-resolution insights often inaccessible via experimental techniques. Coarse-grained (CG) molecular modeling, in which atoms are bundled together into supra-atomic particles, extends the space and time scales accessible via MD simulations and is increasingly employed to characterize systems of interest in structural biology, drug discovery, biophysics and nanomaterials design . Martini is a popular CG modeling scheme, which provides pre-parametrized molecular fragments (beads) for creating molecular models in an additive fashion. Non-bonded interactions between CG beads are described via simple spherical Lennard-Jones (LJ) and Coulomb potentials, parametrized according to the miscibility and partitioning of their associated molecular fragment between different solvent environments (top-down route), while bonded interactions are usually calibrated based on equilibrium simulations of higherresolution molecular models (bottom-up route). The resulting simplification of the molecular systems enables a speed up of 2 to 3 orders of magnitude with respect to equivalent all-atom (AA) modeling .