Glucose biosensor strips for point-of-care applications typically consist of screen-printed electrodes with a small volume capillary channel for sample loading. To integrate the enzymatic O2-scavenger into these sensor strips, the electrode layout and capillary channel were specifically engineered to create and maintain anaerobic conditions at the sensing electrode (Figure ). CAT and AOx were deposited on the inner surface of the capillary cover, while paraformaldehyde was distributed in solid form on a thin paper within the channel serving as spacer (Figure ). The concentrations of the scavenger components were increased four-(AOx) to ten-fold (paraformaldehyde) to account for concentration heterogeneities within the capillary upon filling with the sample. GOx and the Os-complex modified polymer were dropcast onto the working (sensing) electrode. When the aqueous sample fills the channel, the O2 scavenging enzymes dissolve and spread throughout the channel, initiating O2 depletion (Figure ).