Similarly, the concept of chemical multiverse has recently emerged as an approach to capture alternative chemical spaces of a compound data set given by different molecular representations. In this regard, the constellation plots, which are based on the concept of analog series, are visual representations of chemical multiverses that facilitate SP(A)R analysis, including the analysis of virtual screening campaigns. We would like to emphasize the advantage to look beyond the traditional chemical space typically composed of small organic compounds obtained from medicinal chemistry and computational efforts such as de novo design.