Instabilities inherent to the Boresch restraint scheme were highlighted by the failure of several simulations, even with sensible restraint parameters which imposed a minimum energy penalty of around 10 k B T for collinear anchor points. The use of multiple distance restraints offers an alternative restraint scheme which lacks the instabilities of Boresch restraints and may improve convergence during decoupling by allowing greater restriction of ligand movements. The theory of multiple distance restraints was discussed and a rigorous implementation of the multiple distance restraints scheme was proposed. This utilised intramolecular rigidification of anchor points to prevent coupling between the internal and external DoF. This was shown to produce free energy estimates in good agreement with the Boresch restraints, at least within the large uncertainties encountered with this system (Figure ). This scheme incurred a substantial additional computational cost over Boresch restraints because aggressive rigidification was required to counter the strong intermolecular restraints, but the scheme may offer benefits where more permissive intermolecular restraints are used.