It is worth stressing that neither RAMD nor iMetaD is integral to this method: each of them could be swapped for a different approach should it be more convenient for the task at hand. For example, RAMD could be replaced by other direction-agnostic methods while path CVs could be replaced by a machine-learning approach for CV discovery to provide a more general description of the unbinding process. Nevertheless, we find that the exploration/exploitation pattern within a single automated workflow is the key advantage of the approach presented here.