To investigate this concept further, we calculated LLE values for the entire set of substituted THA derivatives and the reference standards. The logD7.4 values vary from 1.20 to 5.58 (Table ), leading to an LLE range between 0.61 and 4.94 (Table ). It is well-established that an LLE value greater than 5, combined with logD values between 1.5 and 3, is optimal for a promising drug candidate . By analyzing the data in an LLE plot format (Figure ) instead of a potency-only format, we immediately identified the compounds worthy of further optimization because they have the highest LLE rather