While the work presented here represents a milestone in our efforts to move beyond just continuous glucose monitoring, we believe the potential value of the specific approach used herein deserves additional comment. At this time, it is our opinion that the device presented here has strong utility as an academic research tool because: (1) the device presented leverages use of simple disc electrodes, which are widely utilized for in-vitro electrochemical sensor development; (2) leverages use of commercial FDA-approved microneedles, thus easing development burden for other groups desiring to move to human testing; and (3) places the sensors ex-vivo such that any materials that are not-biocompatible simply need be locally immobilized, easing development burden regarding safe insertion into and removal from human subjects. This said, however, it is difficult to speculate on the potential clinical utility of this microneedle device. As such, the technology described here may speed the ability in which others are able to pursue human testing of continuous biosensors.