ELIDIS is easily adaptable to the detection of different target antibodies by simply changing the recognition element conjugated to the DNA strands. To demonstrate this, we engineered an antibodyresponsive DNA strand displacement reaction for the detection of anti-DNP antibodies (Figure ). This platform showed concentration-dependent current signals (Figure ) that allowed detection of anti-DNP antibodies in 80% bovine serum with a dynamic range (between 3 x 10 -13 and 2 x 10 -11 M), sensitivity (K1/2= 3 ± 1 x 10 -12 M; LOD = 3 x 10 -12 M) (Figure ) and specificity (Figure ) comparable to those observed with anti-Dig antibodies.