Many cancers metastasize to bone, including prostate, breast, and myeloma cancers . Cancer cells dysregulate the bone remodeling cycle by secreting osteoclastogenic cytokines that initiate bone resorption to make room for tumor growth . This increased remodeling leads to increased bone formation during the early stages of tumor growth . However, continued remodeling results in a tumor-initiated resorption rate that exceeds that of bone formation. It also increases the rate of tumor growth, which is stimulated by the TGF-β released from the bone matrix during resorption. Eventually, the growing tumor fills the resorption cavity before osteoblast signaling occurs . Cancer cells also secrete molecules besides cytokines to promote bone resorption or inhibit bone formation. For example, myeloma cells produce DKK1 to prevent osteoblast development . These are just a few examples of how cancer and bone interact; readers are referred to and references therein for further details. The complex interplay between multiple organ systems in metastatic cancer means that almost all cancers have adverse effects on bone health .