MD is the most commonly applied sampling technique in the construction of RMLPs, since it captures true trajectories of molecules and covers a wide range of PES. Herein, to address structural sampling on rare events, we categorize frequently-used MD sampling methods into Classical dynamics and Enhanced sampling dynamics (Umbrella Sampling, Metadynamics). Utilizing MD-guided sampling offers a significant benefit as it naturally samples dynamically significant regions within the configuration space. Furthermore, enhanced sampling dynamics can be employed to dynamically expand the set of points, ensuring the inclusion of undersampled regions during the course of trajectories.