Our crystallographic experiments resolved a total of 29 unique compound-bound structures, which included 7 starting materials and 22 reaction products (Fig. ). When looking at target-bound reaction products from successful syntheses and usable X-ray diffraction data after soaking, we achieved a hit rate of 2.27% (22/969) (Fig. ). This is a lower hit rate than regular fragment screening with previous crystallographic XChem fragment screening against this crystal form yielded a 6.51% hit rate with similar soaking conditions. The low hit rate is also likely due to inadequate compound designs as this exercise was mostly driven by the available chemistry around the starting fragment. We anticipate that better compound library designs will increase the hit rate of future experiments.