It consists of non-structural proteins (Nsp), Nsp proteins (Nsp1-11and Nsp1-16), these proteins commonly occur in coronavirus . Furthermore, these Nsp proteins (Nsp1/2, Nsp2/3 and Nsp3/4) form the replicase-transcriptase complex (RTC) that creates an environment inside the host body suitable for RNA synthesis and replication. Nsp12 codes for the RNA-dependent RNA polymerase (RdRP) domain, Nsp13 is encrypted with RNA helicase domain and RNA 5′-triphosphatase, Nsp14 encodes exoribonuclease (ExoN) which helps in replication conformity and finally, Nsp16 encodes 2′-O-methyltransferase activity. All of these findings emphasize the vital role of the Nsp proteins, thus any interruption of their binding with a ligand or each other or conformational change will render them unfunctional.