Metal Organic Frameworks (MOFs) are porous crystalline materials composed of metal oxide building units linked by organic linkers. The chemical diversity, especially the possibility of tunable host guest interaction, gives MOFs great potential for a wide variety of applications, not limited to energy storage, gas or molecule separation, sensing, water harvesting and purification, nano-catalysis, and drug delivery. There are a number of strategic solutions to fine-tune the physical and chemical properties of MOFs, starting from varying their building blocks, adding defects, tailoring functional groups, or by exploring other framework isomers. Isomerism is a structural phenomenon, where a chemical substance -a molecule or material has the same stoichiometry, but is different in the local structure, leading to two or more related structures. In MOFs, this condition could arise from a number of factors as classified by Zhou et al. MOFs with the same component building units but different conformation (i.e. flexible MOFs), interpenetrating structures, and MOFs with a specified topology but consisting of low symmetry building blocks, such that changing the orientation of the building block will create another isomer. matthew.addicoat@ntu.ac.uk (M.A. Addicoat) ORCID(s): 0000-0003-2667-0347 (M. Nurhuda); 0000-0003-1431-6439 (Y. Hafidh); 0000-0003-1517-468X (C.C. Perry); 0000-0002-5406-7927 (M.A. Addicoat)