Here 𝜇 is a different dampening parameter to before and we have set 𝜇 as 0.7 based on trialand-error experiments. This is a good default for our formulations: we hypothesize that a highly sensitive buffer system would require a stronger dampening (lower 𝜇). We use the above equation to calculate the next suggested titrant volume when in the overshoot region. Please see the SI for a sample calculation.