As the ubiquitous driving force in nature, starting from the molecular level building blocks like L-amino acids, D-sugars to nanoscale helical structures found in DNA, RNA and macroscale in conch and snails, chirality is indispensable in our daily life. It is no wonder that the concept of molecular chirality in terms of asymmetric synthesis and catalysis is at the forefront in the development of pharmaceuticals and functional molecules. Moreover, molecular chirality is important because it is closely linked to biomimetics at the cellular level to produce functional chiral materials. Originally described by Lehn as "chemistry beyond molecules," supramolecular chemistry makes use of noncovalent interactions to facilitate the spontaneous organizing of constituents into structures or patterns without the need for human involvement. In the case of non-symmetric extended spatial packing, which can be caused by the aggregation of molecular building blocks (with or without chiral centers), the resulting architecture would be chiral at the supramolecular level, also known as supramolecular chirality. Notably, chirality transfer, chiral amplification, and asymmetry breaking of either chiral or achiral components upon selfassembly can all cause supramolecular chirality to develop. In addition to improving our comprehension of the inherent homochirality observed in complex biological systems, rationalizing supramolecular chirality in multicomponent systems has significant implications in the pursuit of developing functional chiral materials. In this review article, we attempt to present a comprehensive account of the recent development of the supramolecular chirality within the self-assembled systems over the past few years, with a particular emphasis on the aspects of (i) chiroptical properties and (ii) enantio-selective separation in multicomponent systems. Notably, multicomponent systems are more complicated than single-component systems due to the possibility of integrated co-assembly, narcissistic self-sorting, heterojunctions and their mixtures, especially when assembled from achiral molecules, making chirality determination difficult. As it is a rapidly growing field with numerous examples reported regularly, we intend to enclose our discussion to the field of co-ordination self-assembled systems namely porous metal-organic cages (MOCs) only. First and foremost, our primary objective revolves around the characterization of supramolecular chirality. Subsequently, we delve into the intricate processes of chirality transfer and amplification, specifically examining the induction and transmission mechanisms from the constituent organic ligands to the self-assembled metallacages. The establishment of subtle chiral microenvironments enables chiral hosts to selectively interact with one enantiomer in comparison to the other, thereby bestowing exceptional capabilities in chiral separation and recognition. Later, the potentialities, prospects, and critical concerns pertaining to this domain are examined. directionality of such non-covalent interactions determines the ultimate geometry of the assembly, but to design a selfassembled structure only based on the non-covalent interactions is a tedious job given the dynamic and reversible nature. Therefore, stronger interactions like dynamic covalent bonding or metal-ligand coordination are required to minimize the dynamic nature of the final assembly to a greater extent and stabilize the final geometry. The discrete coordination assemblies are generated from metal ions and organic ligands, mainly focusing on the generation of convex polyhedra, that are surrounded by organic ligands clipped together via the metal-ligand coordination bonds. Featuring enclosed 3D space, such polyhedral structures can be mainly divided into two main classes, (i) Platonic solid, comprised of only one type of identical polyhedral edges or faces, and (ii) Archimedean solids, which are formed by at least two kinds of different polygonal planes (Figure ).