Reaxys TM database contains S-Zanubrutinib (Reaxys IDs: 27490480) and its enantiomer (Reaxys IDs: 27490481) and racemic mixture (Reaxys ID: 27490479), as shown in Fig. . Searches of 12-steps routes from all of them were conducted, in case missing useful reaction information, especially sub-routes that were not relevant to the chiral centre could be identified. The long-range search was performed in a backwards manner staring from these three IDs. Main search parameters adopted include: