resulted from greater occupancy of the HFF cleft, we obtained an X-ray crystal structure of this compound bound to SmBRD3(2) (Figure , PDB code 7AMH). ). The acids 10 and 14 showed solubility of >259 μM and >260 μM, respectively, under these conditions; compound 10 has a chromLogD of 2.83 and 14 has a chromLogD of 1.78. The esters 17 and 22, however, have lower solubility of only 1 μM and 13 μM, respectively. The chromLogD value for 17 is 7.61 and for 22 the value is 5.95, indicating that these compounds are more lipophilic than the acid derivatives, as expected. These data suggest that we are unable to measure the SmBRD3(2) affinity of the ethyl esters due to poor solubility, and we cannot be certain whether these compounds have any affinity for SmBRD3 (2).