One potential signature of dimerization propensity is the presence of dimer-characteristic structure in the monomer ensemble, which would reduce the free energy of reorganization on dimerization. However, we found no consistent secondary structure propensity differences in either the dimer or the monomer between glycoforms or between glycoforms and the wild type. This was also true after examining additional monomer structures 1JCO , 1MHJ , and 2JV1 . This suggests to us that such structural analysis alone of glycoforms will not allow us to determine dimerization propensity, and so we explored different metrics to assess dimerization.