We have analyzed blocking effects in chemotactic systems influenced by both background gradients and enzymatic consumption in bacterial microcompartments. Our fully analytical model, validated by numerical simulations, captures the key features of these interactions, including stagnation contours that shift with blocker size and consumption rate. These findings provide insights into how local substrate gradients can be significantly reshaped by actively consuming obstacles, deepening our understanding of intracellular transport in crowded or complex environments.