As we have shown it above, the SP query allowed us to execute the synthesis route finding queries up to reaction step 3 in reasonable time on our original +/+ database. In this experiment, we also compared SP query on various Neo4j database configurations with and without multiproduct and ambiguous reactions in attempt to gain more speed performance. As shown in Figure , the removal of multiproduct reactions dramatically improves the Neo4j query execution time by several orders of magnitude at search depths of ≥ 2 reaction steps. In fact, the observed differences were indeed statistically significant in multiple cases in the light of our statistical framework (see section " Statistical Significance Testing"), as shown in Figure , Table ??, in SI.