Another stable multicomponent system was formulated by dispersing Lap disks within Tyrfunctionalized-HA (HA-Tyr). Herein, the dual-charge of the nanosilicates allowed for interaction with both the HA chains of opposite charge and peptide amphiphiles containing a proangiogenic osteonectin fragment (GHK-Ca 2+ ). It resulted in a hybrid hydrogel whose dynamic interactions ensured a very fast relaxation profile, described as crucial for triggering the proliferation and differentiation of recruited progenitor cells toward an osteoblastic phenotype. In a sinus rabbit model, this hybrid hydrogel enhanced the formation of new bone after both 6 and 12 weeks when compared to the other treatments, also including the commercial product Bio-Oss (Figure ). Blue arrows point blood vessels filed with RBC within the new bones and yellow circles show foam cell-like which engulfed the implanted hydrogels. Adapted with permission. Copyright 2020, Wiley-VCH.