As 1 represents a potentially useful starting point to access numerous polycyclic, furanocembrenoid-derived marine natural products, rapid gram-scale access through total synthesis is essential as semi-synthesis is not currently a sustainable option. The retrosynthetic analysis described herein for 1 benefitted from the wisdom of four prior elegant syntheses. 2c-f Foremost amongst the invaluable insight gained from those studies was the use of a highly effective NHK macrocyclization (first reported by Paquette to prepare similar structures). The use of this disconnection necessarily leads one back to the common acyclic bis-furan precursor 6, deliberately Scheme 1. Gram Scale, Convergent Synthesis of (-)-Bipinnatin J a a For detailed reagents and conditions, see Supporting Information.