Previous work has shown SCs exhibit relatively strong fluorescence emission, with a prominent emission band centered at ~350nm that is conserved across all major structural classes. When adsorbed onto physical matrices (i.e., paper), SC emission can be deconvolved from background autofluorescence with irradiation from a sufficiently bright UV-C light source. In E-cigarettes, SCs are present in a heterogenous e-liquid vehicle that consists of propylene glycol (PG), vegetable glycerin (VG), flavoring compounds and nicotine. This e-liquid is not directly removable from many types of e-cigarette pods for subsequent analyses. E-cigarette actuation is draw activated; inhalation is detected by an airflow sensor that responds by heating an atomizer coil to vaporize surrounding e-liquid. To extract e-liquid nondestructively, we have developed a device that can artificially actuate an e-cigarette while simultaneously depositing its vapor onto a physical matrix. We have paired this extraction approach with in-line optical elements capable of performing generic detection of SCs (as in ref 30), to rapidly inform on drug content. A schematic of the device is shown in Figure .