HME was carried out on a ZE 9 HMI extruder (Three-Tec GmbH, Seon, Switzerland) at 100°C in all three heating zones to ensure the formation of a continuous filament. The screw speed was set to 25 rpm for the whole extrusion process. The total amount of polymer and IND used for each round was about 5 g which did not allow the use of continuous feeding.