Good practices to ensure reaction reproducibility. As mentioned before, results obtained from different experiments while using the same reaction conditions can vary to some extent, especially when working on a small scale. There are a few good practices that can be adopted to ensure reproducible results. When all these requirements are strictly followed, these variations can be considerably minimized. The lithiation/1,2addition sequence is extremely sensitive to moisture, meaning that all the components used in this transformation must be freshly distilled and dried. While developing this work, it was found that the azeotropic distillation of the LiBr and quinoline 1 consists of good practice to obtain the lowest water content possible in these materials. Unfortunately, the same procedure cannot be used for ketone 2, which can easily decompose at distillation temperatures. Compound 2 is usually commercialized in its more stable hydrochloride form, and therefore, needs to be neutralized prior to performing the BA reaction. Ideally, neutralized ketone 2 should be used right away, as its decomposition towards enone 19 takes place over time. Once neutralized, ketone 2 must be dried at room temperature under vacuum and inert atmosphere; these operations will ensure low levels of impurities.