Following on from this initial dissemination, we expect the dual modeling approach to be utilized in a wide range of future studies. For example, the method can be used to rapidly determine the Hammett reaction constant, ρ, for new synthetic methodologies and sustainable alternatives, providing predictable applicability for different substrate classes. Furthermore, we anticipate exploration of additional PAT instruments, such as chromatographic analysis, to provide more insight into impurities and allow more precise quantification of reaction intermediates. and sustainable chemistry throughout the global chemistry enterprise. The ACS GCI Pharmaceutical Roundtable is composed of pharmaceutical and biotechnology companies and was established to encourage innovation while catalyzing the integration of green chemistry and green engineering in the pharmaceutical industry. The activities of the Roundtable reflect its members' shared belief that the pursuit of green chemistry and engineering is imperative for business and environmental sustainability. The Research Center Pharmaceutical Engineering (RCPE) is funded within the framework of COMET─Competence Centers for Excellent Technologies by BMK, BMAW, Land Steiermark and SFG. The COMET program is managed by the FFG. The authors acknowledge Markus Tranninger and Patrick Frisinghelli for discussion and assistance during the Julia software development.