Similarly, intratumorally injected Au-coated Dox-loaded liposomes incorporated into a CS hydrogel, enabled localized photo-chemothermal therapy. Additionally, when administered in together with a SC injected nanovaccine (i.e., antigen & adjuvant loaded PLGA NPs), this hybrid hydrogel effectively combined chemo and immunotherapy in a melanoma tumor model. The thermal effects of Au NPs, particularly through a mild temperature increase of up to 40°C, have been also described to suppress the production of pro-inflammatory cytokines