While Hellmers and König showed that their general scheme also includes MFCC as a special case and makes it possible to include many-body effects on top of the MFCC fragmentation , their general scheme becomes rather involved and requires calculations for additional fragments and combinations thereof, thus losing the simplicity of the MFCC scheme with its chemically meaningful fragments. This quickly becomes intractable, and for this reason they proposed to use formyl and amine caps (i.e., replacing the methyl groups in the caps by hydrogens) instead of the ACE-NME caps. However, this is a worse representation of the chemical environment of the severed peptide bonds, which may deteriorate the accuracy.