Recently, we introduced the concept of generic EME conditions , designed to streamline method development by providing starting conditions for efficient extraction of analytes within a defined range (termed extraction window) of charge (z) and hydrophobicity (log P). A key goal of generic conditions is to lower the barrier to EME's adoption and to provide both novice and seasoned users with standardized conditions compatible with commercially available equipment. Developing generic systems primarily concerns the selection of a suitable liquid membrane. For example, 2-nitrophenyl octyl ether (NPOE), a much used solvent in EME, has an extraction window of 2.2 ≤ log P ≤ 6.4 for +1 ≤ z ≤ +2 . The establishment of generic conditions is also tied to the operational stability, which mainly concerns the extraction current produced during transfer of charged species. As such, a low current (<50 µA ) minimizes the effects of water electrolysis at the electrodes, which otherwise induces gas formation, pH changes and results in poor extraction efficiency. High current may arise from too high conductivity of the liquid membrane, a too water-soluble solvent that leaks during the extraction, or poor discrimination of matrix components. Thus, it is recommended that the water solubility of solvents in EME should not exceed 0.5 mg mL -1 , and should remain stable in presence of highly complex samples.