Once promising hits are discovered, they need to be developed further quickly. However, synthetic challenges often impede this, demanding more time and resources than appropriate. This problem is also mirrored in a poll from Dan Erlanson on his blog "Practical Fragments". Although not representative, almost three-quarters of the participants could often or sometimes not develop a fragment due to synthetic challenges. Even more concerning is that nearly two-thirds of all participants had complete fragment-to-lead projects often or sometimes impeded by these issues (Figure ). : Adapted poll results from "Practical fragments" show a concerning degree of synthetic challenges in fragment to lead projects. The poll was run on the website from 14 June to 16 July 2021. There were forty-two responses to the left question and forty-four responses to the right question. Regarding this issue, St. Denis et al. roughly classified fragments into two groups during a review of Astex's in-house libraries: sociable and unsociable. Whereas unsociable fragments have barely any accessible growth vectors and few commercial analogues, sociable ones can be developed in nearly all directions with robust chemistry, and large numbers of follow-up compounds are purchasable. The latter are the fragments desired in libraries, but based on the poll results, the former are concerningly widespread. We encountered the issue of unsociability ourselves in the follow-up to one of our crystallographic fragment screens. For a promising fragment, the necessary growth vectors were not accessible, and no buyable compounds modified in the required position were purchasable. The fragment was developed into a novel, potent inhibitor nonetheless, but it needed more time and effort than should have been necessary. With sociability in mind, we started to look for fragment libraries that address this issue.