Recent groundbreaking advancements in rational DNA-programmed nanomaterials for biomedical applications, such as biosensing, bioimaging, drug delivery, and therapy , have the potential to initiate a significant transformation. The design and production of DNA nanocomputing circuits have been evolving in recent years, even utilizing microfluidic platforms . It is now possible to estimate the feasibility of producing future DNA computers, whether at nano or other small scales, in vitro, inside cells, or even in vivo. This opens up exciting possibilities for the development of 'bio-nanorobots' in precision medicine.