We calculated the overlap of SAVI with three large databases (Table ) : the REAL database from Enamine , the iResearch Library from ChemNavigator/Sigma Aldrich 1 , and PubChem . For PubChem, we measured an overlap rate of 0.3%, i.e. >99% of the SAVI products are not in PubChem. Still, this small percentage corresponds to more than 5 million molecules that are in both databases. Among those are structures that have biological assay data (186,291 compounds). Overlap analysis with DrugBank V.5.1.5 showed that 547 SAVI compounds are in fact drugs. These compounds show that SAVI does generate "real" molecules.