The overall yield for the optimized process is 78%. Based on this the material cost for ADQ has been calculated as $16.91 per kilogram, resulting in a material margin of 58%. This is slightly better than the target margin of 57% defined in the scope of this project. Therefore, if the process developed in this project is to be commercialized and ADQ sold at an average market price of $38.80/kg, it will yield an acceptable raw material margin of 56%. Because of the improved technology developed by CPT, the selling price can be reduced by 13% to $33.80 and still yield an acceptable raw material margin of 50%. It can thus be concluded that CPT was successful in optimizing the known processes and lowered the required selling price by 13% at current low materials cost. In conclusion, 4,7-dichloroquinoline (5), 4-amido-2-(diethylaminomethyl)phenol ( ) and amodiaquine dihydrochloride dihydrate (3) were synthesized on kilogram scale, with the current project resulting in the successful development of a robust, economically competitive, scalable and reproducible process that can be transferred to a commercial process for the manufacture of the antimalarial API amodiaquine dihydrochloride dihydrate (3).