carbohydrate fragments offer the advantage to alter the pharmacokinetic/pharmacodynamic (PK/PD) profile and can help to gain insight into the structure-activity relationship (SAR) of biologically active molecules. Amino sugars are carbohydrates with at least one hydroxyl group being substituted for an amine. They are widespread in nature and contribute to the biological activity of many natural products. The basicity of nitrogen has for example been linked to an improvement of the active transport of macrolide antibiotics into the cell. The most prevalent members are 2-amino sugars. In connection to our group's research on novel fidaxomicin-derived antibiotics, access to a 2-amino-ᴅ-noviose derivative could enable further glycodiversification of fidaxomicin derivatives. We envisage an altered PK/PD profile by merging the noviose moiety with the biologically relevant 2-amino sugar functionality.