A general problem pertinent to the vast majority of membrane simulations is the lack of electronic polarizability effects. Indeed, standard force fields employed in membrane simulations are non-polarizable, meaning that atomic charges are fixed. This does not reflect reality where charged, or polar objects (i.e., ions or polar molecules) can polarize neighbouring molecules and thus effectively change their charge distributions, which if not considered results in several artifacts listed in Table . Explicitly polarizable force fields aim at fixing this problem. However, they have not been widely employed in biomembrane simulations yet.