For some host-guest systems, nearly equivalent methods gave significantly different BFEs, which remains rather puzzling. It is likely that such BFE discrepancies originate from differences in system set-up and/or sampling of relevant configuration space. Not surprisingly, methods which differed by multiple simulation parameters, despite using the same energy model, also gave different BFEs. In comparing methods with multiple differences, we can't draw any conclusions. Overall, then, further work is needed to ensure that differences in host-guest binding predictions can be traced to their source.