Only chemical properties (LogP, fi, and DrugClass) were selected for the RRF-BP model. This was the only tissue that did not require the Kp values of other tissues to predict its Kp value (Table ). This could be in agreement with the fact that adipose tissue is completely different from other tissues in terms of composition as mentioned already . Additionally, the properties selected could include lipophilicity, which is directly linked to the drug's affinity to adipose tissue . Hence, we can conclude that the parameters selected for adipose Kp are interpretable and reliable. However, because this model had a higher RMSE (0.49) than the RRF-BP models of other tissues, the Kp prediction for adipose tissue remained difficult (Table ).