For example, the γCD derivative sugammadex, which is widely used to reverse the action of the paralytic drugs rocuronium and vecuronium post-surgery, works by binding directly to the paralytic agents and thus reducing their free concentration . There is also promise in the use of cyclodextrin derivatives in the treatment of Niemann-Pick disease and atherosclerosis . Thus, new data for CD-guest binding may have pharmaceutical implications beyond SAMPL.