The mechanistic insights into synthesizing anisotropic gold nanomaterials have been explored for decades. Recent progress indicated that surfactants and silver ions inhibited the typical crystal facet of growing gold nanomaterial, although the detailed mechanisms are still controversial . Thus, improving the methodology for fabricating nanodevices with moderate symmetries has not been sufficiently investigated because of the limited mechanistic insights, and this represents a hurdle to the development of biocompatible nanodevices for controlling small nanostructures in a cell.