Figure shows the convergence of the properties' average values for 200 molecules generated at the end of each iteration. All properties converged well after 11 biasing iterations, which took ~1.5 hours in our system with one NVIDIA P5000 GPU. In the end, the obtained generator can suggest molecules with all properties close to the average values of those of the already approved COX-2 inhibitors in the market, except for the docking score, where we requested a more stringent limit.