As a biological proof-of-concept, curcumin-loaded Psomes effectively induce cervical cancer cell death under acidic pH conditions. This property could facilitate the guided migration of microcarriers in physiological environments, directing them toward acidic tumor sites where the antitumoral nanoreservoirs become active. However, further studies are needed to validate the cytotoxic effects on sperm-microrobots and assess the dual therapeutic potential in more complex models.