the zinc ribbon domain of the target nucleic acid binding (TNB) domain of the CRISPR-associated endodeoxyribonuclease Cas12f1 and analogous sequences found in all domains of life, is represented by Cas12f1-like TNB(IPR010095). This domain is also present in bacterial transposons; however, it does not demonstrate dsDNA nuclease activity. Rather, it efficiently binds to dsDNA targets in a PAM-dependent manner. It seems that Cas12m effectors frequently exhibit DNA binding activity without cleavage.