Biochemical models incorporate interactions between key molecular signals and bone cells but often neglect critical mechanical signals. Mechano-chemo-biological models are a newer third category of bone remodeling models to address the need for sufficient biomechanical and biochemical detail . Here, we provide a comprehensive review of biochemical mathematical models of bone remodeling. We include a few mechano-chemo-biological models in this review to highlight how they consider changes to the biochemical bone remodeling network. A recent review of existing mechanical models of bone remodeling is provided by Della . The review of Ait complements our review of biochemical models but distinctly emphasizes the experimental evidence for biochemical models of bone diseases, such as osteoporosis, Paget's disease, and bone metastases. Unique among other reviews , our review analyzes the mathematical forms used to represent the physiological processes of bone remodeling, highlights important local and systemic biological features found in mathematical models, and synthesizes these into comprehensive tables that should be useful to others interested in building or adapting such models (Tables ). organizes their discussion of existing models by the biological features but does not comprehensively review the models. Instead, their focus is on summarizing a wealth of relevant clinical data for parameterizing such models. We intend for this review to motivate systems biology researchers to look at bone beyond the local microenvironment to better understand the complexities of bone within the body as an integrated whole while still using past accomplishments in localized mathematical modeling and experimental data.