The basic part of isothermal titration calorimetry is the observation of the change of heat due to a complex formation in a reaction cell while keeping the temperature constant. The guest component B is sequentially added to a solution of the host component A. Details on that method can be found in literature of Freire, in Analytical Methods of Supramolecular Chemistry by Schmidtchen, as well as in reviews by Thordarson. The basic ITC equation 8 describes a sum over all formed complex species multiplied with corresponding heat of formation. In contrast to NMR and UV/VIS titrations, the pure host signal does not contribute to the observed heat. At the current state, SupraFit only makes use of models, that are of fixed stoichiometry and equal to the well known NMR titration models, that are summarised in section 3.3. Furthermore, SupraFit handles titration experiments with both, a fixed-volume set up as well as a set up with variable volume.