Severe changes in the strains especially the H5N1 strain of avian influenza viruses have been discovered such as mutations in the HA sequence . Currently, there are 20 lineages of influenza A and B viruses, each of which has multiple different strains . Due to several subtypes, antigenic mutations occurring most often, and unpredictable epidemic patterns; there are worst outcomes of influenza vaccines against some of its strains which further enhances the requirement for a universal influenza vaccine . Moreover, Avian influenza viruses also affect poultry, birds as well as humans and therefore are a cause of concern. Low pathogenic AIV might become highly pathogenic significantly affecting poultry. Out of all the strategies implemented up till now for reducing its spread in poultry, mass vaccination is still considered an appropriate approach. Some vaccines are under research and some are licensed for usage and production on a large scale. A review has discussed the AIV vaccine progress and has focused on traditional and next-generation platforms, dendritic targeting strategies as well as nucleic acid delivery systems to increase immunization . Importantly, 2 doses of vaccines are required for each individual to get the perfect immune response . Available influenza virus vaccines target HA protein and are strain-specific. So universal vaccine is required. A recent review has discussed the influenza P a g e 9 | 56 vaccines available up till now which meet two criteria i.e. Those which are in clinical trials and those which are designed for providing immunity against different influenza virus strains . Due to enormous efforts, universal influenza vaccines have been developed that trigger the broader antibodies or T-cell responses specifically for influenza viruses including CD4+ and CD8+. Some of the effective strategies for this include selection of the required strain, changing HA protein, identification of antigens providing broader immunization, and utilizing particular vector adjuvants can enhance the responses of T-cells. These combined techniques might aid in the development of universal pandemic vaccines for different influenza strains .