The C/d approach involves conducting unbiased MD simulations of phenol in carbon tetrachloride mixtures that were conducted with Gromacs 5.0.7. The simulation box contains a mixture of both compounds, with approximately 11000 molecules in total. Specifically, we conducted MD simulations of three solutions with increasing solute concentrations (0.115, 0.45 and 1.1 M) incorporating 10000 solvent molecules and 111, 434 and 1060 solute molecules into a starting cubic simulation box with edges of 12.0, 12.5 and 13.0 nm respectively. Over the simulation, bonds containing hydrogen atoms were constrained using the LINCS algorithm, allowing a time step of 1 fs for the integration of the equations of motion (using the leapfrog algorithm). Particle-mesh Ewald was considered for the calculation of long-range electrostatic forces, using a cutoff of 1.1 nm. The same cutoff was used for the short-range van der Waals forces. The general AMBER force field (GAFF) was used to model solvent and solute molecules. GAFF parameters were taken directly from virtualchemistry.org.