Studies on chemical reactivity within aerosols have so far been performed in the steady state, often using pre-mixed reactants, and predominantly on aerosol particles formed via electrospray ionization (ESI) with mass spectrometric detection of products at trace concentrations. There are particular gaps regarding applicability to more complex, multi-step transformations, the contribution of atomization versus ESI charging to the observed reactivity, and the possibility of scaling procedures up to amounts that would be useful synthetically or for bulk detection using techniques less sensitive than MS. Here, we endeavor to tackle all three of these extant challenges. Firstly, we present a general experimental framework for timeresolved synthesis and discovery in the aerosol phase, alongside an accompanying standard physical implementation which does not depend on ESI. In principle, our implementation is easily scalable to the milligram-to-gram level, removing a barrier to adoption by synthetic chemists.