1. Polymeric Nanoparticles: In this the curcumin is encapsulated in a biocompatible polymer like PLGA, chitosan or PEG (Polyethylene Glycol). In this the release of Curcumin is slow and controlled which enhances the antimicrobial activity over time. Due to slow and controlled release it has increased stability and reduces cytotoxicity. Effective against drug resistant strains [16,78,87]. 2. Lipid-Based Nanoparticles: There are mainly two types of lipid-based nanoparticles: a) Solid lipid Nanoparticles (SLNs): In this the Curcumin is embedded in a solid liquid matrix . b) Nanostructured Lipid Carriers (NLCs): It is composed of a mixture of solid and liquid lipids for better drug loading .