compound 1) as model SH-trigger. We observed gradual gel dissolution was observed over the course of 168 hours, while no degradation occurred without thiol initiation (controls: only compound 1 without SH-trigger and no additives) (Figure ). Note that although no Hydrogel degradation is based on the concept that, after addition of 4, the self-propagating reaction with 1 successfully releases TPPTS within the hydrogel matrix, where it is free to diffuse and propagate the cascade through phosphine mediated disulfide reduction on crosslinker, generating new thiols (new signals). The progression of the self-propagation continues until complete physical degradation of the material (t = ~168h). In comparison, hydrogels exposed to TPPTS alone (1.5 eq. vs crosslinker) showed visibly faster degradation than the thiol triggered amplification system gels by complete dissolution within 50 hours.