For the purposes of comparison, we assessed the hydrogenation of 1b using and hydrogen gas Pd/C (H2) as the reductant. The reduction of 1b using 1 mol% Pd/C gave, after 4 h, a yield of 52% of 2b and 48% of phenol (Scheme 3, and Scheme S10). The amount of the phenol byproduct formed could be decreased by adding 1b using a syringe pump over a period of 3.5 h. In contrast, phenol byproducts were never observed when the Ni foam system was used for the hydrogenation of 1b. The recyclability of Pd/C was therefore assessed on alcohol 1a instead, for which slow addition of the substrate was not needed. The system was tested over a series of 10 runs of 22 min each, and it showed a good but fluctuating performance, yielding 2a in 29 ± 6.8% yields (Scheme 4). The reactions were carried out on a 1 g scale of 1a (6.17 mmol), and the Pd/C catalyst was recovered by filtration (Scheme S11). The mass loss of palladium was not tested due to its pyrophoric nature. The outcomes of the life cycle impact assessment (LCIA) are summarized for both reaction systems, Ni and Pd, in Scheme 5. The impact categories of the Pd/C system were all set to 1 for the internal normalization with the Ni foam system. In general, the Ni foam method showed larger contributions for every impact category that we assessed. For human toxicity, ecotoxicity, eutrophication, and climate change, the Ni foam represented an increase in the range of 1.5 to 6.3 times the contribution of the conventional Pd/C method. For acidification, a 14-fold increase was observed for the Ni foam case. While the resource use potential impacts were reduced for the catalyst alone for the Ni foam method compared to the Pd/C method, the resource use impact for the full system was 50 times higher, with the major contribution from the platinum counter electrode. Hence, while potential impacts on resource use was reduced for the catalyst, as sough for, the screening LCA provided insights for further optimization of the environmental performance by addressing the use of the Pt electrode. The contributions for each impact category per functional unit are presented in the Supporting Information (Section S4.2).