The main protease encoded by the Wuhan fish market coronavirus is very highly homologous to SARS CoV 3CL pro , whereas the virus overall is more highly related to bat coronaviruses. Homology models of the Wuhan coronavirus protease were built from known SARS 3CL pro crystal structures in both ligand-bound and apo forms. These represent potential starting points for structure-based drug design and for suggesting point mutations to inform future biochemical experiments.