We then carried out the optimisation for Schotten-Baumann reaction based on 20 initial experiments generated by MaxPro (Figure and Table ). The optimisation was completed after 39 experiments as hypervolume had not improved after the 29 th iteration. The results show the trade-off between STY and E-factor: the optimal STY was 8.29 g L -1 s -1 with an E-factor of 1.32; on the other hand, the optimal E-factor was 0.65 with a STY of 3.11 g L -1 s -1 . The Pareto front consisted of 8 points (Table ).