Moreover, AI and automation techniques might be utilized but proper validation of these methods is also required. Despite these challenges, this might be a good approach to block these GPCRs and Kinases and their signaling pathways indirectly by blocking the viral proteins bind to them. Moreover, future research is required to develop more and more automation techniques for the development of universal pandemic vaccines. Intelligence, bioinformatics, and computational techniques for the automation of universal vaccine development. Our study also discusses the advantages and disadvantages of targeting these proteins and using automation techniques for universal pandemic vaccine development.