Hydrogels are a class of soft materials that are composed of a three-dimensional network of hydrophilic polymer chains. They are capable of absorbing and retaining large amounts of water, which makes them useful in a variety of applications, including drug delivery, tissue engineering, and biosensing. In recent years, hydrogels have gained significant attention in the field of biomedical research due to their unique properties. For example, they can be engineered to mimic the mechanical properties of biological tissues, which makes them ideal candidates for use in the regeneration of damaged or diseased tissues. Hydrogels are a diverse class of materials that can be engineered to have a range of properties and functionalities, making them useful in a variety of biomedical and industrial applications. Here are some of the most common types of hydrogels: 1) Natural hydrogels: These hydrogels are made from naturally occurring polymers, such as hyaluronic acid, chitosan, or collagen. They are biocompatible and biodegradable, making them ideal for use in tissue engineering and wound healing applications. 2) Synthetic hydrogels: These hydrogels are made from synthetic polymers, such as polyethylene glycol (PEG) or polyacrylamide (PAA). They can be tailored to have specific properties, such as mechanical strength, swelling behavior, or drug release kinetics, and are often used in drug delivery applications. 3) pH-responsive hydrogels: These hydrogels are designed to respond to changes in pH by swelling or shrinking. They are often used in drug delivery applications, as the pH of certain biological environments can be used to trigger drug release. 4) Temperature-responsive hydrogels: These hydrogels are designed to respond to changes in temperature by swelling or shrinking. They are often used in tissue engineering applications, as they can be used to create scaffolds that can be easily implanted and shaped. One particular type of hydrogel that has garnered significant interest is the biocompatible hydrogels. The development of biocompatible hydrogels is particularly important for biomedical applications, since traditional hydrogels made from synthetic polymers like polyacrylamide or polyacrylic acid can be toxic due to the presence of residual monomers or cross-linking agents. However, biocompatible hydrogels are made by the materials that are not harmful to living tissues or induce an immune response. For example, they are created by the natural polymers like hyaluronic acid, alginate, or chitosan, or synthetic polymers like sulfobetaine, polyethylene glycol or polyvinyl alcohol, etc. Biocompatible hydrogels have a wide range of potential applications in the field of regenerative medicine, including tissue engineering and wound healing. They can be used as scaffolds to support the growth and differentiation of cells, or as wound dressings to promote healing and prevent infection. Also, they also have potential applications in drug delivery, as they can be engineered to release drugs in a controlled manner without causing adverse effects. Moreover, biocompatible hydrogels can be used in the development of biosensors and other diagnostic tools, as they can be functionalized with various biomolecules to detect specific analytes in biological samples. Here, in this article, we selected two biocompatible nature materials: dextran and polyethylene glycol. We created a hydrogel system based on these two materials. Then, we investigated the system in terms of gelation speed, swelling behavior, viscoelastic property and degradation rate.