BindingDB. The external dataset in which positive interactions outnumber negatives was derived from the BindingDB 9 . The activity data with IC50 values targeting human proteins were extracted and labeled into two classes in the same way as in the ChEMBL. training data, a student model is trained with the updated data. This process is iterated by using the student model as the next teacher model. Figure illustrates the workflow of our proposed method using self-training, and the following steps were implemented.