A techno-economic assessment (TEA) of Zimmermann, Gençer reveals critical challenges related to cost and market potential of e-fuels. Notably, OME3-5 e-fuels exhibit significantly higher cost of goods manufactured per gigajoule (GJ) compared to conventional diesel fuel available at gas stations in Germany. Additionally, the study indicates that less than 38.4% of electricity can be efficiently stored in the e-fuel based on lower heating value. The most substantial economic barriers identified in the analysis are associated with electricity consumption and the cost of electrolyzer stacks, rather than the OME conversion cost. Even with a significant reduction in electricity or electrolyzer prices, the OME3-5 anhydrous pathway would not be economically competitive under current conditions. This emphasizes the need for significant advancements in reaction processes and system improvements to enhance the economic viability of OME3-5 e-fuels in the future.