To date, DAC technologies have predominantly relied on chemisorption of CO2 using amines and solid alkali hydroxides, due to their strong affinity for CO2. However, the regeneration of adsorbents is the dominant source of the total operational costs. To mitigate these issues, physisorption-based materials with weaker CO2 interactions have been explored to reduce regeneration costs with repeated usage. Among these, metal-organic frameworks (MOFs) stand out due to their high surface area and remarkable tunable properties. However, the chemical space for forming MOFs is vast due to the large number of possible chemical building blocks and topologies.