This force field combination is motivated by the work of Cheong and Boon, where the ability of MD to simulate 𝛼glycine crystallization was studied with four different force fields (CHARMM, GAFF, OPLS, and Gromos), two water models (tip3p and SPC/e), and five charge sets (CNDO, DZP, DNP, LCAO, and 6-31G * ) . Of all the force fields, charges, and water model combinations studied, only the GAFF/CNDO + SPC/e water combination produced the correct sign of the enthalpy of solvation, and hence was the only single force field set capable of simulation glycine crystallization . The sensitivity of the enthalpy of solvation to the molecular force field is well illustrated by previous glycine crystal growth simulations of Banerjee and Briesen, where bulk glycine crystal dissolution in aqueous solution was only observed, despite the high supersaturations and low temperatures employed, using the Gromos53a6 force field with SPC water .