Effective drug combinations have been occasionally discovered in the clinic , and there has also been an increase in preclinical experimental efforts to identify synergistic combinations reported in the literature . Employing combination therapy in the context of pancreatic cancer addresses the disease's heterogeneity and adaptive nature, leading to enhanced treatment efficacy and offering a promising strategy to overcome resistance mechanisms . Though a few computational models have been reported in the literature recently , the extent of combination synergy in the context of pancreatic cancer remains largely unexplored.