Mechanochemistry, the use of mechanical loads to trigger or influence chemistry, can enable otherwise forbidden reactions , strengthen aerogels without limiting their elongation , and prompt mechano-chromic/catalytic/fluorescent reactions in mechanophores . Mechanochemistry is also believed to play a role when materials are subjected to extreme dynamical loads such as during planetary collisions and shock initiation of explosives . Over the last few decades, significant progress has occurred towards an understanding of covalent mechanochemistry in organic and molecular solids . Experiments with exquisite resolution have revealed the strong effect of mechanical forces on chemistry. For example, atomic force microscopy (AFM) determined the force-extension response of individual covalent bonds and opened the door to a variety of experimental and computational studies on the effects of applied forces to chemical reactions . Single molecule force clamp spectroscopy studies of reduction reactions of disulfide bonds showed an exponential dependence of the reaction rate on the applied force . Numerous experimental and theoretical studies have explored and characterized mechanoluminescence, mechanocatalysis, and mechanochromic responses. Electronic structure calculations have shown that elongation forces on mechanophores can induce isomerization and ring-opening reactions, the reduction in strength and distribution of stresses in knotted/entangled polymers, explored the mechanical stresses in protein folding, and assessed the rupture force and electronic properties for extension and scission of metal-organic junctions. These types of studies use specialpurpose methods to characterize the effect of pair-wise external forces on chemistry including steered molecular dynamics (SMD) , constrained geometries simulate external force (CoGEF) and explicit force methods such as FMPES (force-modified potential energy surface), EFEI (external force explicitly included), and EGO (enforced geometry optimization).