It is not the goal of this work to qualify and compare different fingerprint algorithms, since the described substructure search results were obtained with an ABAS on all compounds of interest (not only on a subset), as accurate results were the prime interest and search time was not an issue. However, a combined compound normalization + fingerprinting + substructure search process was also used to identify PFAS compounds from the extracted structures, as this method would probably be used in the future by typical chemistry database users to identify PFAS compounds.