Also, most of the compounds had logP greater than 5 mol/L except for compounds 7c, 15d, 18d, and 21d with logP equal to 4.218 mol/L, 4.680 mol/L, 4.907 mol/L, and 4.567 mol/L respectively. Since the likelihood of successful oral absorption and interactions with molecular targets tend to rise as hydrophobicity increases, it is crucial for drug molecules to have this property. However, when hydrophobicity increases, the likelihood of effective renal or biliary drug excretion from the body decreases. The biotransformation of hydrophobic drug molecules into more hydrophilic ones, often known as metabolism, is a crucial step in the process of eliminating medicines from the body. As a result, compounds with strong hydrophobicity and hydrophilicity balance typically have better ADME profiles (Bachmann, 2009). These compounds also met Diana et al optimal conditions for bioavailability. All of the compounds fulfilled Ghose's total number of atoms and all of the them are in accordance with Lipinski rule of five. All the compounds exhibit less than 5.0 threshold score for lipophilicity at physiologic pH logD7.4. The Quantitative estimation of drug-likeness (QED) of the selected hybrids falls between range 0.168 to 0.413. These scores are much lower than 0.67 threshold for attractive compounds. All the compounds fall within the easy to synthesize scores (1-4) for their synthetic accessibility (SA) score. The selected hybrids exhibited less than 0.42 fraction of sp 3 hybridized carbon suggesting that they have low to moderate flexibility. The medicinal chemistry evolution 2018 (MCE-18)