The TVSA ANN also appears to generalise very well. In the ESI Figures S20-S21, the global sensitivity samples plateau at a work equivalent of ~1.2 MJ kg -1 . When we constraint the purity to 98% (i.e., Figure ), the global sensitivity samples plateau at a higher value of ~1.3 MJ kg -1 , which is above the thermodynamic minimum work of ~0.5 MJ kg -1 for this purity constraint. In contrast, the S-TVSA model appears to generalise more poorly and is likely simply regressing the data rather than picking out real features from the process. In Figure , the predicted work equivalent of the S-TVSA ANN does not plateau, and the results from the region of very low work equivalent (less than ~2.