There are also cases where the user may be interested in a specific transition state regardless of the availability of the model reaction. This motivated us to investigate ways in which the model reaction transition state could be used to accelerate the search for transition states of larger members of the same reaction class. The schemes that we benchmark here have three steps: atom sequence mapping, geometry alignment, and selection of a sampling scheme for escaping local minima (Fig. ). The differences in sampling scheme distinguish the four approaches that are benchmarked here.