The presented Cheminformatics Microservice provides straightforward access to the open-source cheminformatics toolkits RDKit, CDK, and OpenBabel, as well as deep learning-based tools such as Deep lEarning for Chemical ImagE Recognition (DECIMER) for OCSR and Smiles TO iUpac Translator (STOUT). Building on top of these tools and toolkits, it makes a diverse selection of important functionalities needed by cheminformaticians on a daily basis accessible via a RESTful interface. Additionally, Cheminformatics Microservice includes a number of widely used packages, like the ChEMBL curation pipeline , CDK-based sugar removal functionalities , and the open-source structure generator surge . The presented microservice is intended to facilitate the handling of large amounts of chemical structural data to enable the development of adaptable, scalable, and maintainable cheminformatics applications.