Ionization energies and electron affinities have been calculated via the second derivative of the energy w.r.t. the scaling factor of the cavity used in XP-PCM. In a combination with Conceptual DFT (CDFT), the derivative of the energy w.r.t. external pressure allowed the calculation of a range of chemical properties and it was found that ionization potentials, electron affinities, electronegativities and polarizabilities decrease upon increasing pressure, whereas the chemical hardness increased. The above examples demonstrate that pressure influences the electronic structure of atoms funda-mentally. As a result, the very nature of the chemical bond changes and some astonishing effects can be observed. Noble gases, for example, become reactive under pressure. Although it is in many cases unclear whether the interatomic contacts involving noble gas atoms can rightly be called chemical bonds, the observed interactions between noble gases and other species suggest that the concept of the chemical bond must be overthought in the high-pressure regime.