;11 Cells. CRISPR cMyc-HiBiT MV4;11 cells (Promega) were plated at a density of 5 × 10 4 cells per well in solid, white 96-well tissue culture plates (Corning Costar #3917). Following an overnight incubation, they were treated with 1-100nM of the indicated compounds and at the plotted time points, and cMyc levels were determined using luminescent measurement with NanoGlo HiBiT lytic reagent (Promega). Replicate plates of all compound treatments were prepared and at identical timepoints as the protein level measurements, and cell viability was measured using Cell-Titer Glo (Promega). Plates were shaken on an orbital shaker for 10-20 min before reading luminescence on a GloMax Discover Microplate Reader (Promega).