Experimental validation confirmed the computational predictions. One of the suggested azetidine catalysts was successfully synthesized and demonstrated an eightfold increase in catalytic activity over DABCO. The results validated the computational methodology and provided the first de novo discovery of an efficient catalyst using a generative algorithm. Recent experimental work by Arthur-Baidoo et al. on positron binding and annihilation in aromatic molecules supports the role of electron-positron correlations in determining binding energies. Their results show excellent agreement with the many-body theory, reinforcing its predictive accuracy.