As a final remark, we emphasize that we clearly see the massive effort required in future research and education that it will take to push the existing theories and technologies further to accomplish the grand challenges ahead of us. Undoubtedly, a collaborative international, interdisciplinary effort in research and education is necessary. This cannot be done alone by a few research groups. This is a call to arms for the computational scientists to continue innovating using all the new tools available for us on a daily basis.