To gain deeper insights into the structural similarities and evolutionary relationships of TSs in corals, we conducted a phylogenetic analysis using the neighbor-joining method. This analysis revealed that coral TSs form a distinct branch, separate from those of sponges, microbes, and plants, as well as oxidosqualene cyclases (OSCs) in marine invertebrates (Fig. ). Notably, the TSs responsible for the biosynthesis of biflorane, cembrane, and eunicellane skeletons exhibit close phylogenetic relationships, suggesting a potential evolutionary connection. Further investigation of the cyclization Previous research has extensively explored the chemical composition of marine invertebrates, such as corals and sponges . Our study introduces a new research paradigm, beginning at the genetic level to identify new terpene synthases, progressing through biosynthesis, and ultimately aiming to develop marine-derived terpenoid drugs.