Blastermaster 47 is a command line tool that generates docking models for protein target binding sites. DockOpt builds upon Blastermaster by creating multiple models in a single pass and then optimizing parameters based on the retrospective docking performance observed for these models. DockOpt evaluates models using a specified criterion, such as normalized LogAUC (also called "enrichment score" 50 . To efficiently evaluate many candidate models, DockOpt employs a designated job scheduler (e.g., Slurm) to test several models in parallel. In summary, DockOpt enhances the functionality of Blastermaster by integrating model evaluation and concurrent optimization into the process of generating docking models.