Societal drivers. The connection between science and the current drivers for society is deep and cannot be ignored. This century poses several severe challenges that range from the rapid rise of income inequality and the apparent cracks of the neoliberal structure to the stresses on the environment due to industrialization. The work of simulation scientists therefore is linked directly or indirectly to this societal context. In particular, the solutions to many of the challenges related to this century ranging from the discovery of novel materials for renewable energy, to that of environmentally-friendly pesticides or next-generation antibiotics require tools to be developed by our field.