The synthesis of small molecules is integral to a variety of disciplines, from materials science to medicinal chemistry. For complex small molecules, efficient chemical synthesis requires detailed retrosynthetic planning (1) and experimental evaluation. These plans usually involve one or more key steps that generate significant structural complexity. When key steps initially fail, different iterations of the key step are attempted, which is time and resource intensive to the extent that strategies are sometimes abandoned. This process has unfortunately been necessary as nuanced changes in substrate structure often result in significant changes in chemical reactivity that are challenging to predict.