In this context, we used tetrakis (triphenyl phosphine) palladium (Pd(PPh3)4) as a precursor in a simple solvothermal step and successfully obtained a MOFs structure with highly dispersed Pd, which has been investigated for application in high selective vanillin hydrodeoxygenation under super mild reaction conditions of room temperature and one atm of H2. Specially, we used an as-prepared Pd@MOF catalyst in selectively hydrogenation or HDO of lignin-derived aldehyde and ketone compounds to obtain the corresponding chemicals by controlling the reaction conditions. In addition, the nitrobenzene derivatives can also achieve the reductive transformation to obtain the corresponding amines under mild reaction conditions (RT, 1 bar H2). Notably, Pd@MOF is prepared by a one-step solvothermal method and wraps super small Pd particles, and the Pd particles are homogeneously distributed on the NH2-MIL-125 (Ti) MOF support leading to the excellent catalytic efficiency.