There are cases where one polymorphic form has one tautomer while the other has a different tautomer or mixture. Using mechano-chemical treatment, a thermodynamically less stale tautomeric form can be transformed into a more stable tautomer. The processed solid state can be studied using FTIR, powder XRD, HPLC, UV, and optical microscopy. In addition to these, broadband dielectric spectroscopy is a very sophisticated method used to detect and monitor tautomers of drugs. Different dosage forms may also affect the ratio of tautomeric forms, e.g., the thickness of the nanometric layer. The diketo form of curcumin is favored in low concentrations in liposomes. In higher concentrations, the keto-enol form is dominant in liposome-based nanoformulation. Guest systems like cyclodextrin and beta-cucurbits for pharmaceuticals have shown huge potential for improving their stability, solubility, compatibility with other ingredients, and dissolution rate. If a drug is tautomeric, these carriers selectively can entrap on tautomer over others with improved physiochemical properties. Moreover, the degree of derivatization of the carrier system can show selectivity for one tautomer over another. 17