Certainly, it is important to note that this comparison only allows us to consider the accuracy in predicting the negative class, i.e., non-umami, and therefore it represents a partial comparison. It is also worth mentioning that the performance values for the umami taste (Supplementary Table ) generally surpass those for bitter and sweet tastes (Supplementary Table and Supplementary Table ). This can be attributed to two main factors: (i) the limited number of confirmed umami compounds in the compounds not necessarily peptides, allowing the exploration of a wider chemical space compared to previous umami predictors . In summary, VirtuousMultiTaste has demonstrated remarkable performance compared to previous taste-specific predictors, with the added advantage of being able to predict multiple taste sensations at the same time.