Although often overlooked, particularly in the description of organic chemical transformations, the description of fully balanced reactions is an important feature when exploring the development of more intelligent synthetic design algorithms. Stoichiometrically accurate description of reactions lead to better insight into proper reaction controls (e.g. temperature, mixing) and monitoring and most importantly in post-reaction processing to isolate the product of interest. In the example shown here in the R-SPL file reaction-fully-annotated.xml provided in the supplementary material ZIP file, an amide is formed through the use of an activating agent (1-Cyano-2-ethoxy-2-oxoethylidenaminooxy)dimethylamino-morpholinocarbenium hexafluorophosphate (COMU) , which reacts with the acid to form an activated ester that then readily reacts with the aromatic amine moiety to form the product indicated. As a consequence of the activated ester formation the urea byproduct N,N-dimethylmorpholine-4-carboxamide is formed followed by the hydroxyl amine moiety ethyl cyanohydroxyiminoacetate (oxyma) upon reaction with the amine. In addition, the hexafluorophonic acid byproduct is trapped as the triethylamine salt.