Synthetic cannabinoids (SCs) are a class of designer drugs that replicate the physiological effects of tetrahydrocannabinol (THC) via binding to cannabinoid receptors CB1 and CB2. Several structural classes of SCs have entered the illicit drug market, arising from iterative structural diversification around a common architecture. Physiological effects of newer SCs are divergent from early compounds synthesized as cannabimimetics, whereby complex interactions outside of CB1/CB2 agonism have been reported. Notably, these off-target effects may be responsible for the toxicity reported for a wide range of SCs. In the UK, SC consumption is prevalent in the homeless community, where SCs are smoked in herbal preparations, and in the prison estate, where SC-soaked paper is smuggled in as contraband. Recently however, e-cigarettes have emerged as a popular delivery vehicle for SCs, consistent their rise in their popularity as nicotine delivery devices amongst young people. E-cigarettes appeal to young people through attractive packing and availability in a wide variety of flavors, whilst also providing an unsuspicious route of drug administration. Indeed, a major demographic for SC-containing e-cigarettes appears to be school age children. 31% of children up to age 17 have tried cannabis, meaning dealers can exploit the appeal of e-cigarettes to mis-sell SC-containing e-liquid as cannabis extract. Data from the UK drug checking service WEDINOS shows that 41% of 122 drug-laced e-cigarettes submitted for testing between January 2023 and April 2024 contained SCs . Notably, none of these samples were submitted with the purchase intent of SCs (Figure ). As SCs are more potent than THC and present in e-liquid at unknown quantities, the risk of overdose is higher, with potentially severe side-effects including respiratory depression and cardiac arrest . Further, recent work demonstrates that SC e-cigarettes are becoming less expensive, with a median cost of as £3.39 / mL, and as little as £1.60 / mL; cheaper per unit volume than a commercial e-cigarette .