In the amidation step the feed solutions of 6, 2a, TBD and 7, were prepared in DMSO, due to poor solubility in the previously-used MeTHF/MeCN solvent system. The same reactor setup was used as for the previous reaction step. The dynamic runs screened the following chemical space: 0.3 -0.5 M of 6, 1.0 -2-.0 equiv 2a, 0.0 -0.5 equiv TBD, temperature 50 -120°C, and residence time 1 -8 min. In the last experimental point, the concentration of TBD was completely omitted to confirm that no reaction was observed.