Activation process is very crucial step to prepare MOFs for practical applications. Hence, during the activation or drying process, removal of the solvent from a weak framework may induces structural collapse and loss of crystallinity. Therefore, understanding how severely removal of the inter-pore solvent can affect the framework, and its connections with geometrical and mechanical properties of MOF can help in selecting the right activation method and guide the design of robust MOFs. In this regard, this research investigated the activation of MOFs with copper paddlewheel metal node. The aim was to spot the correlation between the likelihood of successful activation and some geometrical and mechanical properties of the MOFs. Also, this work considered the severity of the solvents and the role they play in facilitating or worsening the activation. The results showed that there is strong correlation between the mechanical properties of the MOFs and the probability of collapsing. Hence, the collapsed MOFs have very low mechanical properties, represented by bulk, shear, and young moduli. Accordingly, MOFs with decent strength but reported to collapse were isolated, and the activation process was repeated using advanced techniques. Moreover, these findings could help in selection of a proper activation method, optimizing the activation conditions, or introduction of structural modifications to boost the framework resilient to collapse encounter.