To compare the Jaccard distance values between different metal-based compounds of different categories, Figure illustrates the paired distance of each compound ordered by category. We remark that the metal-based compounds contained in the imagenology category exhibit constant lower distances values, indecently of the category to compare their compounds. These results demonstrate that the metal-based fingerprints (especially Metal-FP3) as the potential to be used on clustering algorithms and/or virtual screening campaigns, in which the main objective is to identify similar compounds concerning a control (e.g., with a key bioactivity or property). Figures and show that Metal-FP3 is capable of identifying inter-and intra-similarity differences between each pair of compounds, depending on their clinical category, followed by Metal-FP2 and Metal-FP1, respectively.