We have applied here several improvements to the DW-BEL and ADV algorithms that were incorporated step-by-step during the last months into different protein / ligand pair models 48, 58, 46 , 44 , 35 . However, deeper explorations of lower molecular weight targets, targeting the C-terminal KcsA ,together with the screening of sequence-specific homologous cavities of all human Kir variants, would demand higher computer memories to best penetrate into the vast chemical space to increase the probabilities to identify drug-like molecules .