To further evaluate generated PROTAC, its OPCs were docked into the binding pocket of PTS, which is composed by E3 ligase and POI, to obtain their docking scores. The docking procedure usually contains two parts, i.e. initial conformation/pose sampling to obtain multiple starting points and the following conformation minimization from the sampled starting points. For PROTAC molecule, its large size will result in large conformational search space and accordingly lead to long computation time. Searching for global minimum of PROTAC also becomes difficult due to the large search space, therefore it is not guaranteed that, in docking pose, the POI warhead and E3-ligand motifs can adopt similar poses as in the reference ligand. To address this problem, we choose to use the "local-only" mode (or refine mode) to do docking, in which the initial pose sampling stage was skipped and the input conformation was taken as the sole starting point for optimization. The "local-only" docking solution was taken as the final conformation of PROTAC molecule and its docking score was used as a scoring component for RL. The docking component from DockStream that is fully compatible with REINVENT was served as the interface between REINVENT and docking software and DockStream supports various docking programs. In this work, we chose AutoDock Vina for doing "local-only" docking, its docking score was used as a scoring component to evaluate the PROTAC molecule in RL loops.