In the case of the FG Cypher query and +/+ database configuration, individual query times can be up to hours! Due to such long query times we do not show of query time distributions involving multiproduct reactions and the FG query. Otherwise, time distributions for each step in the workflow, where each step summed is the total workflow time are shown in Figure S??. The steps involve synthesis graph query, route enumeration, yield aggregation and route ranking. The time distributions of the FG query are shown in Figure . The results of the figure compare the FG query execution time in the case of the -/+ and -/configurations. The query time distributions for both -/+ and -/-appear to be the same, with the exception of a slight difference in reaction step 1. The difference however is such a small time that this could probably be attributed to things like fluctuations in computational resources.