We have worked on correlation between physicochemical properties of protein-ligands and binding affinity to protein targets by virtual screening. The virtual screening is an important tool, which widely used as a computational high throughput screening. In this research we showed higher binding affinity and also compare with drug like properties. According to 'rule of five' which molecule contain molecular weight is less than 500, logP is less than 5, H-bond acceptors less than 10 and H-bond donors is less than 5, these molecule show higher binding affinity and show drug-like properties.