Despite continued efforts to use rational approaches to automate and accelerate drug development, the endeavor still requires creativity and human intuition. Currently, the role of human intuition is essentially limited to highly trained people in the pharmaceutical industry and a small set of specialist academic groups. Here, we set out to engage a larger non-expert community in the drug design process. To enable this, we extended the Foldit interface with a small molecule design tool ('Drugit'). Foldit is a molecular biology modeling game which has previously been shown to leverage the creative potential of 'citizen scientists' to predict and design protein structures . Through the gamified Foldit interface, members of the public can suggest protein structure modifications which can be experimentally verified. This is made possible due to cutting edge protein modeling tools with state-of-the-art scoring and incentivization. Likewise, other such games are Phylo , GalaxyZoo 6 and Eterna . In these games, 'citizen-scientists' can productively contribute to open research questions, adding value to open innovation together with open science platforms such as SGC's open science or Boehringer Ingelheim's opnMe.com. Despite most Foldit players having limited prior design knowledge, the Foldit interface is tailored to encourage productivity in solving design problems, a situation which can be an even greater multiplier for people with prior domain-specific knowledge.