To test whether running some newer functionals in ORCA (6.0.0) would lead to substantially faster results and prevent fair comparisons of timing, we ran all r 2 SCAN-3c calculations in both ORCA 6.0.0 and ORCA 5.0.3. We found the calculations run in ORCA 6.0.0 were indeed slightly faster, but that the effect was inconsistent and small relative to the timing differences discussed in this study: calculations run in ORCA 6.0.0 completed in 91±40% of the time that analogous calculations run in ORCA 5.0.3 took to complete. Given that the methods discussed in this study span approximately 17 orders of magnitude in speed, we do not anticipate that the difference between ORCA 5.0.3 and ORCA 6.0.0 will impact our conclusions.