Finally, ERK has also been implicated in the THC-D1 receptor mediated effects. A study that used male CD-1 mice has shown that in striatum administration of acute THC activates ERK. When SCH-23390 was used, it has been shown that the activation of ERK decreased in striatum. This result may indicate that the D1 receptor is involved in THC-stimulated ERK activation . Additionally, Daigle et al. (2011) have found that when treated with HU-210, striatal HU-210-dependent ERK1/2 signaling in striatum decreased more than in the wild-type models. The research also suggests that D1 receptors might act as a signal transduction of CB1 cannabinoid in an opposing manner .