The ℎ term accounts for conformational degrees of freedom. ℎ equals to 3, 2 and 1 for sp -, sp 2 -and sp-hybridised atoms, respectively, and ℎ is assumed to be 4 for any other type of hybridisation, such as sp x d y and sd x in transition metals. Thus, the term ℎ is directly related to Fsp3, for which typically a saturated compound with a high content of sp 3 carbons receives a higher score than a similar unsaturated structure. SPS also accounts for the stereogenicity of an atom, where (pseudo)stereogenic tetrahedral carbons and atoms involved in a double bond with possible E and Z isomers are assigned 𝑠=2, otherwise, the term is equal to 1. The stereoisomeric term 𝑠 is thus strongly related to FCstereo. The value of the ring term 𝑟 is 2 for all atoms being a part of a non-aromatic ring system. Atoms which are part of an aromatic ring or linear structure are scored with 𝑟=1. The different score for non-aromatic compounds reflects that corresponding elements typically have more spatially intriguing features and conformations. Finally, the score accounts for the number of heavy atom neighbours of the atom under consideration. For example, an atom with bonds to two heavy atoms has 𝑛=2, and an atom with connections to three heavy atoms is assigned 𝑛=3. The branching of the molecular skeleton is accounted for by squaring the 𝑛 term.