Our search in the CAS Content Collection for ART-related documents retrieved over 50,000 scientific publications (mostly journal articles and patents) for the period 2000-2024. The number of related documents has consistently grown over the last two decades, more than tripling in that time (Figure ). Reflecting the early success of in vitro fertilization, form the 1980 the number of ART-related research has exhibited exponential growth (Figure , inset). Figure summarizes the top patent offices with the most ART-associated patents. The World Intellectual Property Organization (WIPO) and the China patent office are the notable leaders. We surveyed the substance data extracted from the CAS REGISTRY 17 regarding the types of substance classes commonly associated with ART. Our analysis indicates that proteins/peptides/nucleic acids and small molecules are most commonly associated with ART (Figure ). In patents, proteins/peptides/nucleic acids represent ~60%, and in journals ~86% of publications. Small molecules are the second largest group, with 12% in journals and ~40% in patents (Figure ).