Nonetheless, such strategies might lead to practical limitations. For instance, even relatively small libraries of somewhat complex molecules might lead to a combinatorial explosion while exhaustive substructure enumeration. Furthermore, synthetic interpretability is not prioritized in this approach, thus leading to a harder rationalization of the results. Therefore, matched molecular pairs obtained through retrosynthetic fragmentation gradually developed into several applications relying on analog series computational identification, such as analog series-based scaffolds [116], compact chemical space representations of analog series in constellation plots, and the novel SAR rationalization approaches. Another application of analog series yet to be fully harnessed is virtual screening in ultra-large libraries.