radical (R.; with a rate constant kda) by the higher oxidation state catalyst complex CuIIX2/L, after homolytic cleavage of a R-X bond by a transition metal complex, such as CuIX/L (with a rate constant ka). Notwithstanding their adaptability, these RDRP procedures have undesirable color, toxicity, and odor because of catalyst/catalyst precursor leaching (for ATRP and SET-LRP) and sulfur chain ends (for RAFT). This made it necessary to create an RDRP method that produced amino acid based biopolymer polymer and allowed for it's potential application. Reports on the zinc catalyst-mediated RDRP are quite rare. Among these is the ATRP of methyl methacrylate and styrene at 80 o C mediated by zinc oxide nanowires. Furthermore, RAFT of N,N-dimethylacrylamide, benzyl acrylate, benzyl methacrylate, and 2-hydroxypropyl methacrylamide in the presence of ZnTPP 9 at 25 o C was conducted on methacrylate, methyl methacrylate at 25 o C. Zinc (Zn) catalyst is one of the most recently developed RDRP catalyst However, the Zinc catalyst has not been explored as a catalyst for amino acid-based RDRP. To the best of my knowledge, Herein, I report, for the first time, zinc catalyst-mediated RDRP of monomer, leading to the synthesis of PBAAM at ambient temperature and a well-defined stimuli (pH) responsive poly(β alanine acrylamide)-block-poly( methyl methacrylate)-umbelliferon (PBAAM-b-PMMA)-UMB diblock amphiphilic copolymer containing pH-responsive PBAAM and hydrophobic PMAA segment Thus I believe that this block copolymer will be employed for encapsulation of dye from aqueous medium and NPs synthesis for DOX-release for Cellular uptake.