In the last years, the number of NP databases has grown, and some of the databases already established are continuously being updated. Among the largest freely available NP databases is Supernatural 3.0 with 449,048 NPs. The Collection of Open Natural Products (COCONUT) contains 411,000 NPs and The Universal Natural Product Database has 229,000 NPs. The Universal Natural Product Database is still accessible on the ISDB website. NPASS database has 94,413 NPs, of them 43,285 are annotated with the biological activity information. Hippo(crates) database contains 45,300 NPs, NP derivatives and synthetic compounds, many of them annotated with their biological targets. There are NP databases that contain NPs isolated and characterized in certain geographical areas. TCM@Taiwan is the largest database of NPs from China, which is employed in traditional Chinese Medicine and contains 58,000 compounds. IMPPAT 2.0 is the largest compilation of NPs from India with 17,967 phytochemicals, employed in traditional Indian medicine. The largest collection of NPs from Africa is AfroDb, containing over 1000 molecules.