For future directions and applications of integrated catalysis, one can exploit the one-pot setups and cooperativity between different catalytic cycles to synthesize a myriad of macromolecules and macromolecules. We envision that judiciously designing the catalyst combinations in tandem catalytic cycles will enables reactions to proceed under mild conditions and improve the selectivity and yield of the overall process. More importantly, integrated catalysis can capture unstable, transient, and hazardous intermediates and subsequently convert them into more stable and valuable products, thus expanding synthetic capabilities. In addition, by coupling an exothermic reaction with an endothermic reaction, thermodynamic leveraging in tandem reactions can drive the formation of otherwise unviable products. Furthermore, breaking down a thermodynamically favorable but high activation energy reaction into a series of reaction steps that can be optimized individually can lower the overall energy barrier and allow the reaction to proceed through milder conditions.