In the GDCC dataset, we cross compared the predictions of similar approaches. The ATM/GAFF2-AM1BCC/TIP3P/HREM and PMF/GAFF2-AM1BCC/TIP3P/MD-US methods used the same energy model and were intended (by the participants) for comparison to one another and for cross validation of the newer ATM method. The methods differ in that the ATM method is alchemical while the PMF method is path-based, and each utilizes a different sampling approach (see the literature for more details).