In response to the urgent global need for precise, sensitive, and rapid diagnostic platforms capable of detecting contagious pathogenic viruses such as SARS-CoV-2, researchers have developed an ultra-precise fast diagnostic platform. The platform is capable of detecting monoclonal IgG antibodies against the S1 protein of SARS-CoV-2 within infected patients' blood specimens with COVID-19 in about 1 minute. The electrochemical-based nanosensor consists of a highly activated graphene-based platform in conjunction with Au nanostars, which can detect SARS-CoV-2 antibodies with a detection limit (DL) and sensitivity of 0.18 × 10-19%V/V and 2.14 μA.%V/V.cm -2 , respectively, in human blood plasma specimens, even in the presence of a high amount of interfering compounds/antibodies. The nanosensor's sensitivity/specificity is remarkable compared with the gold standard (i.e., ELISA assay), confirming its superb performance. In this study, the researchers developed an improved label-free nanosensor