Different benchmark sets have been developed to assess the performance of covalent docking algorithms. consisting of 330 Cys-bound and 75 Ser-bound complexes formed by 8 reactions. A few web sites have been devoted to covalent complex data bases, such as the cBinderDB (no longer accessible) and the CovalentInDB. Recent web sites entirely based on structural data from the protein data bank include the CovPDB server 61 and the CovBinderInPDB. We downloaded the data from both servers on February 1, 2023, yielding 2261 complexes from CovPDB (CPDB) and 3555 complexes from CovBinderInPDB (CBIP). We analyzed the content and quality of these 7 sets (Tab. 1). As docking codes have previously been tested and compared on benchmark sets containing solely serines and cysteines, and as we noted a strong dependence of docking success on the quality of experimental data, we created in the following our own benchmark set (CSKDE95), optimized for structure diversity and quality.