The fact that m 1 A severely inhibits SC2RC may indicate that the m 1 A modification can be very difficult to detect in SARS-CoV-2 RNAs using any techniques even if the methyltransferases such as TRMT6 and TRMT61A of certain individuals could install the modification, and the modification plays a highly significant role in preventing COVID-19. The reason is that once the modification is installed, the virus would not be able to replicate unless it is erased by demethylases timely, in which case, the modification can still be difficult to detect. Probably, the only scenario, under which m 1 A can be detected with relative ease, is that there is a significant interval between m 1 A installation and removal, and thus there is a significant amount of virus in this dormant phase given that genomes with m 1 A modifications cannot be replicated.