Furthermore, as the polymer and IND are heated higher than the extrusion temperature in the DSC run to reach the Tm of the drug, the two components can then merge and the solubility of the drug in the polymer matrix increases. Additionally, if all of the drug gets solubilized while heating, subsequently no melting will be observed , as observed for the samples with polymer:IND w/w ratios of 1:2 and 1:1 (Figure ). However, a residual broad endothermic transition between 110 and 140°C can be observed for the sample containing higher amount of polymer (polymer:IND w/w 2:1) followed by two sharp peaks at 145 and 153°C.