Aging causes modifications in cell signaling at every level. Neuronal and hormonal signaling gets deregulated, causing enhanced inflammation (inflammaging), reduced immune performance (immunosenescence), and alterations in the extracellular surroundings. Altered intercellular communication implicates the change in signaling between cells possibly leading to certain diseases and disabilities of aging. The age-dependent alterations in intercellular communication integrate the effects of the other features of aging. Specifically, senescent cells initiate chronic inflammation, which can further damage aging tissues. Thus, multiple factors bring about the altered intercellular communication, one of which -the SASP -is directly triggered by the cellular senescence.