Despite their identical amino acid sequences and 2D-chemical structures, Vif red and Vif blue bound different A3G/sA3G domains in the cryoEM hetero-dimer model (Supplementary Materials / GraphycalAbstract.pse). Therefore, the Vif red -sA3G consensus top-children conformers predicted by targeting 45x45x45 Å grids, were also ADV blind-docked to include any Vif blue sA3G cavities targeting 60x60x60 Å grids. Because RNA may stabilize Vif blue Vif red A3G complexes, RNA (optimal RNA20 oligomer 9 ) was also targeted.