So, as already known the conversion of harmful (CO) and harmless (CO2) to high-value-added chemicals through hydrogenation/electrohydrogenation reactions constitute an excellent strategy for cleaning our environment from wastes and as well as helps us to make considerable economies from the use of fossil fuels. In this way, in March 2020, it is thoroughly shown from Mejia's research paper that the effect of strong metalsupport interaction (SMSI), by using Ni embedded over niobia (Nb2O5) enhances the hydrogenation of carbon monoxide. Indeed, Ni/Nb2O5 catalyst displays superior TOF and C5+ selectivity than the Ni NPs supported over un-reducible support such as (α-Al2O3). In particular, it was found that higher temperatures prime to a decline in Ni-based catalytic activity, nonetheless stable catalytic performance was multiplied in return with high selectivity of long-chain hydrocarbons. Hence, due to the reducible nature of Nb2O5, and as well as the resulting synergistic effect between Ni and niobia, it is noted that SMSI leads to avoiding nickel carbonyl formation and highly stabilized Ni NPs/Nb2O5 for CO hydrogenation. In January 2012, Hwang, S's group published a research article focused on the use of mesoporous Ni-M (30-10 wt %)-Al2O3 xerogel catalysts for the production of methane from carbon monoxide hydrogenation. Indeed, it was found that an optimal carbon monoxide dissociation energy and large Hydrogen (H2) adsorption gift of the catalyst was necessary for determining the catalytic performance of Ni30M10AX for effective methane production. So, among the tested catalysts, Ni30Fe10AX with the largest H2 adsorption gift and best optimal CO dissociation energy shows the greatest conversion of CO and the highest yield of methane generation from the methanation reaction. Therefore, the improved catalytic performance of Ni30Fe10AX was attributed to the synergistic effect of the formed Ni-Fe alloy, iron affinity to oxygen, and facile reduction. So, it is believed that the Ni30Fe10AX catalyst might be considered for other catalysis purposes, including fuel cell applications, hydrogen production from water splitting, and so forth. Moreover, a long years ago, Ishihara, T's group studied the catalytic hydrogenation of carbon monoxide over Fe-Co/SiO2, Ni-Fe/SiO2, and Co-Ni/SiO2. Under experimental conditions 523 K and 1.0 MPa, hydrogenation of CO over bimetallic/SiO2 catalysts gives higher yields than on monometallic/SiO2 catalysts. Nonetheless, it is suggested that TiO2-supported bimetallic is also very active than silica-supported bimetallic catalysts. In fact, it was found that Fe-Co, Ni-Fe, and Co-Ni catalysts were very active, and selective for the production of olefins, paraffins, and gasoline respectively. Fortunately, it is suggested that the support does not affect anymore the product distribution. In particular, Co-Ni catalyst was regarded as the most active for CO conversion and selective to higher hydrocarbons (gasoline), especially Co50-Ni50 displayed to be the best catalysts. Therefore, it is thoroughly described that the beneficial effect of making supported alloy materials for improving the catalytic hydrogenation performance of carbon monoxide and beyond. Nickel NPs were anchored over diverse supports (ZSM-5, SBA-15, MCM-41, SiO2, and Al2O3) in order to design a highly active Ni-based catalyst for carbon dioxide methanation reaction as pointed out in Guo, X et al's research paper . As a result of a deep study, it was found that due to the basic property and the contribution of the synergistic effect between Ni metal and zeolite (ZSM-5) support, Ni/ZSM-5 exhibit an excellent catalytic property, which makes Ni/ZSM-5 the most active catalyst among these Ni metal supported catalysts for CO2 hydrogenation. In situ infrared spectroscopy confirmed that monodentate formate intermediate reactivity on Ni/ZSM-5 catalyst was more active than that of bidentate formate species. It was also confirmed that Ni/ZSM-5 catalyst possesses powerful stability without catalyst deactivation up to 100 h and has also excellent resistance to coke and sintering effect. Therefore, Ni/ZSM-5 catalyst with a Ni loading of both 10 and 15% might be considered a potential candidate catalyst for harmless CO2, CO harmful hydrogenation reactions, and as well as for other catalysis applications. More recently, Hatta, A.H's group established a brief review on Ni-based supported catalysts for the CO hydrogenation process to produce CH4. The review was articulated in two steps, step one focuses on the singlesupported nickel catalyst by using different kinds of supports (ZrO2, TiO2, SiO2, and Al2O3), and the second step is concentrated on the Bi-supported Ni catalyst using (ZrO2-Al2O3, CeO2-ZrO2, and Al2O3-CeO2). As shown in their study, the Bi-supported Ni catalyst (Ni-Co/CeO2-ZrO2) showed the best catalytic performance for the methanation of CO, with a CO conversion of 100% and a highly selective to methane (99%). It is believed that this excellent catalytic performance might be attributed to the synergy effect between the components, first between Ni-Co, second within (CeO2-ZrO2), and third the effect of strong metal-support interaction (SMSI). Therefore, it is taught that the upcoming research careers can be deeply focused on these aspects: i) making bimetallic catalysts, ii) the use of a promoter, iii) the use of three distinct supports for a catalyst, and the last one is to fully considering the design route of the catalyst as each method has its unique benefits. So, it is concluded that these aspects will affect the physicochemical properties of the resulting materials, which will lead to enhancing the Ni active site, low-temperature processability, and excellent resistance to both coke and sintering effects over Ni-based catalysts. As a result, it would be a great advantage due to the enhancement of the catalyst features and as well as the affordable cost of Ni-based materials as compared to noble metal-based catalysts. The next section will relate to the recent development of Ni-based catalysts for the desulfurization process.