Retrospective Identification of Epigenetic Targets. As a proof of concept on the practical applicability of the herein developed consensus model, we employed it in the retrospective identification of the epigenetic targets for two external and recently reported compounds (Figure ): (1) compound 17, an inhibitor of EP300 and CREBBP, as targets representative of the less populated compound datasets, and (2) compound 43a, an inhibitor of HDACs 1, 3, 6, 8 and BRD4, representing targets with the most populated compound datasets. These results