Adjusting the alkyl chain lengths can modulate the interaction between AIEgens and fungi to improve the treatment effect. Li et al. developed a family of cationic AIEgens with numerous alkyl chain lengths for anti-fungal therapy . Among them, TPA-S-C6-NMe3 + can interact with fungi through electrostatic and hydrophobic interactions. The synergistic effect of alkyl chain length, the ability of ROS generation, and amphiphilicity endow TPA-S-C6-NMe 3 + superior anti-fungi photodynamic activity than commercial PSs, e.g., methylene blue, chlorin e6, and protoporphyrin IX. Furthermore, TPA-S-C6-NMe 3 + was applied for in vivo wound healing, which not only showed an excellent antimicrobial activity but also promoted the regeneration of new blood vessels and fibroblasts in infected tissues.