Complex surface structures are responsible for the remarkable degree of biomolecular selectivity found in nature. Macromolecules bind to these bio-interfaces through multiple weak interactions, with electrostatic and hydrophobic interactions critical in determining selectivity. Twodimensional materials represent promising artificial mimics due to their high specific surface areas and accessible functional groups. A wide range of nanomaterials including transition metal dichalcogenides, MXenes and graphene have displayed an ability to bind biological macromolecules such as proteins and DNA. However, the simple inorganic structure of these surfaces leads to stochastic functionalization with different binding groups, therefore limiting their selectivity.