For the all-atom MD simulation, monomer, glycerol, and glucose molecules are parameterized using the Antechamber package in Am-berTools16 and the generalized Amber force field (GAFF) version 1.7. The atomic charges are assigned using the am1bccsym method of molcharge shipped with QUACPAC 1.7.0 from OpenEye Scientific Software. The CG model of the monomer is built by grouping the atoms in the all-atom model and is parameterized initially using the Martini 3 force field. As shown in Fig 2 , we compare atomistic and CG bilayer simulations to select and modify bead types from the Martini force field to better capture physical detail. There are a number of approaches for coarse-graining the simulation using force matching, relative entropy, or machine learning approaches. Besides being somewhat difficult to implement for larger simulations or implement long simulations efficiently in many packages, these other techniques can potentially introduce overfitting to a single phase. Therefore, we focus on Martinistyle models in our current study.