It is possible to extract TM stereochemistry from an RDKit mol object if the 3D information for a TMC is present. Then one can use the AssignAtomChiralTagsFromStructure functionality to get the TMC geometry and ligand arrangement around the TMC. However, the functionality in RDKit (2024.03.3) does not seem to correctly extract this information. As a result, the connection between the extracted geometry tag and the actual 3D geometry often needs to be questioned. Additionally, the ligand arrangement around the central TM appears to have a random element which makes the tag not trustworthy. We have submitted a bug report going through the details of the issue: .