In our view, there is an important distinction between conformer-dependent charges in this sense (that quantum chemistry assigns charges that depend on the choice of conformer) and what one might call "user-dependent" charges which depend on the specific choice of input conformer, charge assignment algorithm implementation, and hardware platform. In the area of binding and solvation thermodynamics, users want to (and ought to be able to expect to) obtain reliable, reproducible free energy estimates without having to use the same compute platform and agree on what conformer of a molecule to provide as user input.