Comparing the estimated binding energies of the QFVinardo hit list with those for FDA-approved drugs, one can observe that Niclosamide, a proven potent drug against COVID-19, ranks 4th on our FDA list with an estimated binding energy of -6.54 kcal/mol using the Vinardo intermolecular scoring function combined with DFT-D4 conformational strain energies. There are 19 natural compounds on the QFVinardo hit list with stronger estimated binding energies than -6.54 kcal/mol. Therefore, considering the entire QFVinardo and QFVina condensed top 100 hit lists, I believe there is a chance of finding non-toxic natural compounds that effectively inhibit the 6LU7 protein.