Hantavirus is a rodent-borne zoonotic pathogen. Humans can contract Hantavirus after coming into touch with rodent urine, saliva, or excrement. Hantavirus infection in humans is associated with two diseases: hemorrhagic fever with renal syndrome (HFRS) and Hantavirus pulmonary syndrome (HPS) (alternatively called Hantavirus cardiopulmonary syndrome (HCPS) ) . Hantaviruses come from the Old and New Worlds . Hantaan illness has a mortality rate of up to 12% (HFRS) and 40% (HPS) . Fever, muscle aches, and gastrointestinal problems are all indications of human infections . Patients with HFRS have a greater degree of renal involvement, resulting in oliguria. Pulmonary symptoms are more severe in HPS patients, and pulmonary edema occurs in a significant number of individuals(4). Increased vascular permeability is a common hallmark of these two illnesses. It is capable of resulting in hypotension, thrombocytopenia, and leukocytosis . There are currently insufficient interventions available. The primary cause for this is an insufficient understanding of Hantavirus pathophysiology and the virus's molecular mechanism of replication . As a result, understanding the molecular mechanism of vascular leakage in Hantaan disease is critical for vaccine development and disease prevention.