Only one MD (BCUT2D_MRHI) is considered as important in all cases for Bis4MPyC6. A total of 4 MD (BCUT2D_MRHI, fr_benzene, LabuteASA, VSA_EState6) are considered as important by at least 2 algorithms simultaneously. The fact that different methods select different sets of MD, and the results of each algorithm are not completely reproducible with minor changes in the data set, shows that in order to draw any "physicochemical" conclusions from such a study, it is necessary to carefully consider issues of reproducibility. Otherwise, one can draw conclusions based on a random (statistically insignificant) result.