Therefore, this study was planned to investigate the effects of administration of Vernonia amygdalina aqueous extract on hematological and biochemical changes caused by NEU exposure in rats and also its 35 Female albino rats (Sprague-Dawley) were brought in at 45-60g weight at ages 2-3 weeks and bred in the laboratory under ideal conditions of temperature, humidity and light and fed with right rations . The animals' weights were monitored weekly until an average weight of 170g after which carcinogen was given at average ages 7weeks, 7 ½weeks and 9weeks old. The extract was fed to the animals on daily basis by gavage method starting from 2 weeks after the last dose of carcinogen for a period of 4 weeks.