Polarizable force fields potentially help address some of these concerns and challenges. The first general purpose polarizable model was introduced by Arieh Warshel for a water model suitable for biomolecular simulations , building on his work with early QM/MM based approaches. Peter Kollman and Berne and Friesner developed early polarizable variants of AMBER in the 1980s and 1990s, respectively. More recently, the AMOEBA force field has been in development since the early 2000s and was first published by Ren and Ponder around 2002 . Polarizable force fields, and their importance for such systems, are explained in Section 2. In addition, popular general force fields such as AMBER, OPLS-AA, GROMOS, and CHARMM are continuously evolving and polarizable versions of some of these are available . One example of the latter is a recent release of CHARMM's balanced Drude polarizable force field . However, polarizable force fields have been applied relatively seldom in SAMPL challenges; the AMOEBA force field was used in some prior host-guest challenges , but the Drude polarizable force field has yet to be used in a SAMPL challenge.