We describe in this study an alternative strategy that involves, simultaneously, the catalytic production of both enantiomers of the product from a racemic mixture, together with their physical membrane separation. The key parameter for the success of this new type of parallel kinetic resolution is the adequate compartmentalization of the reaction mixture by a membrane with selective permeability [Fig. ]. It should allow the racemic substrate (A/ent-A) to freely navigate from one compartment to the other, whereas the enantiomeric catalytic species (Cat*/ent-Cat*) and the enantioenriched product (B/ent-B) resulting from the parallel kinetic resolution should remain sequestrated in their compartment. An obvious solution to ensure the selective permeability through the membrane is to rely on the difference of polarity between the chemical species present in the reaction mixture.