Differences in molecular complexity and synthetic accessibility provide another way to compare literature and predicted syntheses and retrosyntheses. In organic synthesis, human experimenters often attempt to build up more complex molecules from simpler precursors, resulting in positive differences in these complexity measures for the reaction. There are cases where chemists will synthesize a more complex molecule and then collapse it into the desired product, or when complexity is temporarily increased due to the presence of protecting groups, however these cases are less applicable for the single-step examples we are considering. Figure shows scatter plots of difference in molecular complexity and synthetic accessiblity for forward synthesis and retrosynthesis prediction versus the literature reported reaction. The dashed line bisecting the plot is the identity line and not a trendline.