In this context, different cartographic methods have been proposed to efficiently navigate chemical spaces once a set of descriptors has been selected . Most navigation methods involve positioning a reference query molecule and scanning a large database to identify the adjacent molecules, which are molecules with properties significantly similar to those of the reference structures. Notably, the adjacent molecules to the reference compound can be identified using the full set of descriptors that define chemical space, and this can be performed independently of the visualization method to project the fulldimensional space into a 2D/3D graph.