In order to test the performance of lwreg when registering conformers as well as compounds, we considered the collection of compounds and conformers used to parameterize the DASH tree in Ref. The database contains 365'419 molecules and 1'027'559 conformers. Conformers were stored without hydrogen atoms. The conformer table occupies 3.5 GB of disk space, while the registration data for the molecules themselves occupies about 1.3 GB of disk space. We did three performance tests with this database. Determining whether or not a particular conformer was present in the database and, if so, retrieving the associated molregno and conformer ID took 220 ms for 100 molecules (2.2 ms per molecule on average). Determining whether or not a particular molecule was present in the database and retrieving the associated molregno took 250 ms for 100 molecules (2.5 ms per molecule on average, which is essentially the same timing as the equivalent query for the ChEMBL database discussed above). Finally, registering one new conformer for each of 100 molecules took 1.7 s for the 100 molecules (17 ms per molecule on average).