The most likely source for the discrepancies in MD simulations of charged small molecule binding on membranes is the missing electronic polarizability. While polarizable force fields are available, such as CHARMM36-Drude, they cannot yet capture the lipid headgroup conformational ensembles with sufficient accuracy to enable the usage of headgroup order parameters for the evaluation of small molecule binding affinities. On the other hand, the implicit inclusion of electronic polarizability by scaling the partial charges of atoms in an approach known as electronic continuum correction (ECC) has been shown to correct the overestimated calcium binding to membranes containing charged and zwitterionic lipids. Therefore, we decided to study the effect of electronic polarizability by applying the ECC to CHARMM36-ParamChem parameters of etidocaine and to CHARMM36-QMcharges of TPP. These were used with the recently introduced parameters for POPC where ECC was applied to CHARMM36 lipid force field. Applying ECC increases the binding affinities of both the etidocaine and the TPP molecules to POPC bilayers, leading to an intensified decrease in order parameters in Fig. .