In this section we present our findings from a comprehensive analysis of more than 530,000 publications (journals and patents) in the field of rare diseases sourced from the CAS Content Collection. Our aim for this analysis was to identify interesting trends in the field such as leading research organizations and scientific journals, as well as identify leading rare diseases in terms of commercial exploration. In addition, we have focused on three of the most voluminous (in terms of journal and patent publications) rare diseases -ALS, HD and MG. Finally, we leveraged CAS REGISTRY ® , the CAS substance collection, to identify substances across different substance classes co-occurring with the three chosen rare diseases.