• PDBbind v.2019 Refined: A subset of the PDBbind v.2019 dataset, consisting of 4852 complexes that have been subjected to stricter quality criteria. The final number of structures after curation is 4543 excluding the core set 2016, typically used for testing. The overall range of affinity is from 2.0 to 11.9 log units. The mean range in affinity for a specific protein target is 2.2 log units when considering proteins co-crystalized with at least two ligands.