ChemRICH analysis was performed to facilitate the biological interpretation of the non-target results, as it accounts for both endogenous and exogenous chemicals. Unlike other common approaches such as pathway enrichment analysis, ChemRICH's p-values do not rely on the size of a background database (e.g., KEGG) , avoiding overrepresentation issues. Instead, ChemRICH is study-specific, with a self-contained size. The analysis here considered Level 1-3 annotations; the results are given in Figure (including key annotations in each cluster) and Table .