We next analyzed each mapping using six distinct scores: SOS, SMS, Mapping RMSD Score, MAR, MVR, and MCS Difference Score. Generally for all mapping scores large histogram overlaps were observed using the different mapping methods, hinting at very similar score performance, except for the mapping RMSD score. The mapping RMSD score showed Figure : The Jaccard score histograms illustrate the diversity between two mapping approaches. The Jaccard score compares two mappings by evaluating their selection of atom pairs. A score of 1 indicates identical mappings, while a score close to 0 suggests that the mappings consist of entirely different atom pairs. The comparisons are presented here for each dataset and every combination of atom mapper used.