Aurora-A is a Ser/Thr protein kinase that plays an essential role in mitosis. Aberrant Aurora-A function is associated with cancer development and progression making it an attractive drug discovery target. However, despite entry of numerous active site Aurora-A inhibitors into clinical trials, none have progressed to clinical use. This might arise due to on-target toxicity associated with the essential function of Aurora-A but also because of Aurora-A functions that are independent of its intrinsic kinase activity. This means that active site kinase inhibitors might not suffice to achieve therapeutic efficacy. As an incomplete kinase,