Epigenetic alterations such as methylation, acetylation, succinylation, and newly included lactylation of histones and other protein targets are known to alter the pro-tumor attributes of cancer and cancer-supporting cells including macrophages . Furthermore, accumulating shreds of evidence have shown the existence of an axis between epigenetic changes and metabolic adaptations . At the same time, however, the key insights on the nature of substrate, the biological abundance of a substrate, and associated enzymes are missing.