In this work, we extend the NCMC move classes in BLUES by introducing torsional moves for flexible ligands to facilitate transitions between binding modes resulting due to rotation of rotatable bonds. Figure shows the different steps involved in the NCMC protocol. We identify a region connected to the chosen rotatable bond of the ligand which is able to move freely and only this region of the ligand is alchemically turned off and on during the NCMC move proposal. In the middle of the NCMC protocol after the alchemical region is annihilated, the rotatable bond is randomly rotated, followed by restoring the interactions of the alchemical region.