Z is the Zeldovich factor for homogeneous nucleation, which accounts for the low probability of observing a large population of supercritical clusters that progress to bulk crystals (and is determined by the shape of the free energy barrier in 𝑛). Due to the exponential term in Eq. 4, small changes to Δ𝐹 (𝑛 * ), as determined by Δ𝜇 𝓁→𝑥𝑡𝑎𝑙 and 𝜎 ′ , can result in orders of magnitude changes to crystal nucleation rates.