First, to demonstrate the need for the thermodynamic corrections in the final step of Fragmenstein, the placement of a pair of derivative compounds binding NUDT7 from (deposition group G_1002045) were investigated. NU181 (PDB:5QH1, chemical component: H5G, Enamine: Z1632454068) and PCM-0102716 (PDB: 5QH9, chemical component: GZY, Enamine: Z254513422) were the parent hits for NU443 (PDB: 5QHH, chemical component: H5D, S enantiomer) and NU442 (PDB:5QHG, chemical component: H17, R enantiomer), which were modelled with the chloroacetamide reacted with Cys73. Second, to demonstrate the use of user correction, the placement of the derivative compound binding the tubulin interface from (deposition groups G_1002173 and G_1002214) was investigated. F04 (PDB: 5S4O, chemical component: O0J, Enamine: Z48847594) and F36 (PDB: 5S5K, chemical component: S6V, Enamine: Z2472938267) were the parent hits for todalam-4 (PDB: 5SB3, chemical component: 47F, Enamine: Z48853939). The modelling was done with a custom map in order to flip the N and S atoms in the aminothiazole (an equally plausible orientation given the electron density and required for the elaboration)