Overall, we found that our pose prediction protocol was able to select poses close to the native binding pose with acceptable accuracy. Moreover, we compared the performance of our HYBRID-based docking approach to two standard docking software, namely AutoDock Vina and DOCK 6 and found that HYBRID was more accurate and reliable for RMSD prediction. We also ranked binding affinities using MM-GBSA scores, but the results showed poor correlation with the experimental values.