In both the high and low-similarity bins, the differences in the averaged PLIF similarities of poses generated by DiffDock-L and Vina were minimal. Specifically, Welch's t-test 𝘱-value was smaller than 10 -4 , and Cohen's d was 0.20 for the low-similarity bin. For the high-similarity bin, the Welch's t-test 𝘱-value was 0.10, and Cohen's d was 0.18. These results indicate that the performance of the two pose sampling methods, when stratified by the structural relatedness of the docked compounds, is comparable.