Despite their capacity to mimic the sulfate chemistry of heparin, sulfonated polymer brushes such as poly(styrene sulfonate) (PSS) and poly(sulfopropyl methacrylate) (PSPMA) have not been explored for the direct capture of bone morphogenetic proteins and other growth factors. Whereas PSS has been applied to the captures of proteins , PSPMA brushes have received less attention for such applications, and was investigated primarily as bacterial repellent or bactericidal coating . In this project, the ability of PSPMA to capture bone morphogenetic proteins (specifically BMP-2 and BMP-4) was investigated. The growth of PSPMA brushes through an activator regenerated by electron transfer (ARGET) mechanism was examined first, using ellipsometry, to enable the generation of brushes in ambient conditions, only requiring initial degassing of polymerisation solutions. PSPMA brushes with controlled architecture (density of initiator and thickness) is demonstrated and some of the physico-chemical properties (surface chemistry and solution swelling) are characterised. The capture of BMP-2 and BMP-4 and the impact of PSPMA architecture on this process are then studied, using surface plasmon resonance (SPR) and quartz crystal microbalance with dissipation monitoring (QCM-D). Finally, the formation of fibroblast monolayers at resulting BMP-2 functionalised surfaces, and the ability of these cells to derive mature extra-cellular matrix at corresponding interfaces, is investigated.