In such a case there is a difference in the encapsulation Ks of ⇠ 5 orders of magnitude (Table ). This means that the probability for having 2 cis co-encapsulated in the cavity together with 3 is ⇠ 100 0 000⇥ higher than that of finding a co-encapsulated 2 trans . Despite the fact that, in theory, the 2 trans conformer is found ⇠ 100⇥ more favored compared to the 2 cis one in the cage cavity (see Figure : right secondary axis), such a statistical penalty for having a 2 trans conformer effectively encapsulated within the cage cavity -emerging from the host-guest equilibrium -explains why the experimentally obtained X-ray structures of these complexes always show a 2 cis encapsulated guest.