We performed five different ABCluster simulations for the ionic (SA) 10 (AM) 10 cluster (i.e., using 10 bisulfate and 10 ammonium monomers) for each combination of the simulation parameters: the population size of SN ∈(20,80,320,1280,5120), the number of generations (loops) of gen∈(20,80,320,1280,5120), and the maximal survival lifetime until replaced by another random structure sc∈(1,2,4,8) (for more details regarding the ABCluster parameters see the original papers ). In this case, the quality of the CS is evaluated by the lowest energy configuration found at the MM level. Figure shows the average over all simulations with the same CS power and different sc. It is seen that the quality of CS increases with increasing product gen×SN, which we will refer to as CS power. Hence, the exact choice of gen and SN parameters is not that important, and primarily the CS power determines the quality of CS. However, we recommend a large enough population of at least SN = 100, to guarantee some level of diversity during the exploration. Similarly, the scout bee parameter sc shows only a little preference for the value of 4.