Alkyl iodides could be easily synthesized via Appel iodination reactions from alcohols, which are ubiquitous in natural products and pharmaceutical agents, such as carbohydrates, nucleosides, steroids, and glycosides. Thus, the synthetic utility of this difluoromethylation protocol was further highlighted by the late-stage functionalization of a large variety of alkyl halides derived from complex bio-relevant molecules (Table ). Alkyl iodides prepared from a group of commercially available monosaccharides (ribose, xylose, glucose, galactose, and fructose), some of which contained unprotected hydroxyl groups, could readily couple with the CF2H groups to afford the desired difluoromethylated carbohydrates (48 to 53, 51 to 73% yield). Additionally, fluorine-containing nucleosides have shown desired properties as antiviral and antitumor agents, but their preparation usually required multi-step synthesis. Gratifyingly, with our protocol, two CF2H-derivatives of uridine, a pyrimidine nucleoside, could be straightforwardly synthesized from the corresponding alkyl iodide precursors (54 and 55, 58 and 40% yield, respectively). It is worthy of mention that compound 54 was previously prepared via a 7-step procedure, which involved tedious protection/deprotection steps as well as a preparative HPLC separation of the diastereomers. Moreover, a diverse range of steroids, including cholesterol, pregnenolone, androsterone, DHEA, and estradiol, were converted to their CF2H analogues in useful to good yields (56 to 60, 43% to 61% yield).