In order to examine the accuracy that can be gained from higher-order multipole moments, a calculation on the GLY tripeptide was performed using the so-called M0P2 potential (i.e., using structure-specific charges and anisotropic polarizabilities). This resulted in an RMSD of 9.2 kJ/mol, which should be compared to 2.8 kJ/mol when using the M2P2 potential. It is thus clear that higher-order multipoles provide a substantial improvement.