We gratefully acknowledge EPSRC (EP/Y007859/1; and DTP studentship to O.L.S), The Royal Society [University Research Fellowship, URF\R\201019 (to J.A.B.), and Research Grants (RG150444 and RGF\EA\180031)], Imperial College London for a Presidents Scholarship (to HI and RAC), Pfizer for studentship funding (to J.J.R.), Sir Henry Dale Fellowship jointly funded by the Wellcome Trust and the Royal Society (213435/Z/18/Z, to A. B.).