STAT transcription factor protein interaction (IPR013799) is a member of the STAT protein (signal transducer and activator of transcription) family. When cells encounter cytokines and growth factors, they specifically activate transcription factors in this family to regulate gene transcription. Consequently, they function as signal transducers in the cytoplasm and transcription activators in the nucleus. When these factors bind to cell surface receptors, they cause tyrosine to become autophosphorylated. The STAT SH2 domain can recognize this. This recognition facilitates the recruitment of STAT proteins from the cytosol, as well as their binding to activated receptors.