In this study, we tested five Co-based spinels, Co3O4, MnCo2O4, NiCo2O4, ZnCo2O4, and CoFe2O4, in the partial oxidation of 2-BuOH to MEK. While other studies have focused on the oxidation of 2-propanol in the gas phase with these dopants in low quantities (Co:M 16:1), or in the liquid phase focusing on Co1+xFe2-xO4 and performing the reaction in batch, we tested our stoichiometrically doped catalyst in the liquid phase in flow: the operation in flow is fundamental in order to assess the industrial feasibility of the catalytic process, as it allows better defining of the parameters for future scale-up. This is precious information to aid the transition from homogeneous to heterogeneous oxidations for industries interested in higher alcohols such as the pharmaceutical and the fine chemistry ones. The use of liquid-phase flow reactors in academic research is hindered by the need for expensive specialised equipment and the long operation. The catalysts were synthesised via the combustion method and characterised by XRD, SEM, EDX, XPS, N2-physisorption, and IR spectroscopy. Finally, we also performed reactions in batch for comparison and to corroborate the results, and in the gas phase to assess the impact of a liquid phase on the process.