To gain extensive insights into the micellar structure, small-angle neutron scattering (SANS) curves of CUR solubilized with three different POx and POzi based amphiphiles (Scheme 1) were obtained at various polymer/CUR ratios. Following this, not only morphological transitions from a distinct core-shell to a core-shell-shell model with increasing CUR-loading could be observed, but also the content of polymer, water or CUR in the different layers could be estimated.