To explore the influence of doping on the chemical activity of MoTe 2 monolayers, we conducted oxygen molecule adsorption studies. The findings highlight a significant impact of doping on the local activity of the monolayer, with the extent of this effect being highly dependent on the specific dopant, exhibiting clear trends across groups and periods. In general, group 16 dopants exhibit a limited impact on O 2 adsorption, facilitating similar-type adsorption with a modest increase in moleculesheet interaction energy. Conversely, group 17 dopants display stronger adsorption, leading to significantly enhanced molecule-sheet charge transfer with minimal variations between elements. This results in outstanding sensing characteristics, where the response to adsorption in the sheets' carrier concentration is enhanced by 100-fold compared to pristine MoTe 2 , and sensor recovery is estimated between 0.01 and 2 seconds. Even stronger adsorption interactions are observed when doping with group 13 to 16 elements. However, notable differences exist in this case. The effects are most pronounced for group 13, followed by 14, and finally 15. Similarly, it is observed that the molecule-sheet interaction weakens with higher-atomic-number dopants. Consequently, we predict a robust catalytic potential for sheets doped with B, C, Al, or Si, with the potential diminishing progressively until doping with Pb and Bi results in similar adsorption parameters as seen with group 17 dopants. This suggests comparable potential for sensing in the latter cases.