Having established this link between location and polymer conformation, we investigated how EEK interacts with the different conformational states of the polymers in both the center of the core and at the core-corona interface. We calculated the number of contacts between each EEK peptide and each of the different polymer conformations, taking into account the relative abundance of polymer conformations in the two solubilization locations. This is essential in order to determine whether any preferential interactions exist between specific polymer conformations and EEK, rather than just local enrichment of a specific conformation in certain local environments of the NP (details of these computations can be found in the SI). We define the fractional enrichment, ϵ i , as follows: