show specific linker length preference. In docking to LmPTR1, all compounds selected for synthesis except 1e show standard binding modes of 2-aminobenzothiazole (Fig. ) with hydrogen bonds to the phosphate of the NADP cofactor, and one hydrogen bond between the 2-aminobenzothiazole nitrogen (as an acceptor) and the hydroxyl group of the cofactor ribose. For 1b, the hydrogen bond to Ser111 is not formed (Fig. and), while for 1e the 2-aminobenzothiazole ring is flipped (Fig. ). The tails in all the top poses are in extended configurations, targeting subpocket C' of LmPTR1, similarly to the binding modes for TbPTR1 with the tail in subpocket C (Fig. ).