The transcription capabilities of GPT-4 was firstly evaluated with a SNAr reaction that was also done on a EasyMax 102 synthesis workstation. In this case, the literature protocol provided stir rate, temperature ramping detail and the mass and/or volume of the necessary reagent to carry out the reaction. We purposely let GPT-4 carry out the calculations using the standard prompt (ESI † Table ), which matched the information from the literature. Following the output of the detailed stepwise procedure, each step is successfully mapped to iControl operations according to the given rules, see Fig. . The reaction was executed without modification and was monitored with online-HPLC (Fig. ). We then confirmed the identity of 1-methyl-4-(4-nitrophenyl)piperazine via 1 H NMR spectroscopy (ESI † Fig. ). The complete prompt and response generated by GPT-4 are in ESI † Table .