In an oven dried Schlenk tube 0.37 g of dibromide 1 (0.84 mmol) was dissolved in 11 mL of dry DMF. The solution was degassed three times, then 0.60 mL of Et 3 N (0.43 g, 4.27 mmol, 5.08 equiv.) and 0.13 mL of methylanthranilate (0.15g, 1.01 mmol, 1.2 equiv.) were added with a syringe and the mixture was heated to 130 • C. After 24 hours the resulting mixture was cooled to room temperature and water (28 mL) was added. The resulting slurry was filtered and the solid was washed with water, dissolved in DCM, washed with water (15 mL), dried over MgSO 4 and the solvent was removed by rotary evaporation. Flash chromatography on a 10g column (10-100% DCM in heptane) gave 160 mg of product 5 (purity 69%). In a 50 mL round bottomed flask, 0.12 g of ester 5 (purity 69%, 0.19 mmol) was placed and 20 mL of methanol and 3 mL of aqueous 2M NaOH solution (6 mmol, 31.1 equiv.) were added. The resulting mixture was stirred at 80 • C for 4 hours. The mixture was slowly cooled to RT and 2M HCl was added until the base was neutralised (2.7 mL). The solvent was removed by rotary evaporation. To the obtained slurry 10 mL of DCM was added and the aqueous layer was additionally extracted twice with 10 mL of DCM. The combined organic layers were dried over MgSO 4 . Flash chromatography on a 10 g column (0-50% EtOAc in DCM) resulted in 75mg of product 6 as clean white powder (94%). M.p.: 248-249