One method utilized the polarizable force field AMOEBA , while other approaches used force matching starting from Table . Summary of methods (ranked and non-ranked) used in the SAMPL8 host-guest challenge for binding free energy calculations. The use of explicit and/or implicit solvents is flagged by an (E) or (I) respectively, and a correction approach was taken on methods flagged with a (C). If the host (H) and guest (G) are parametrized with a different energy model they will be flagged respectively. Where a machine learning approach was taken, certain categories are not relevant and flagged with an asterisk (*). Reference calculations are flagged with a double asterisk (**).