The significance of CO2 fixation is self-evident, as it can close the loop of the anthropogenic carbon cycle, additionally allowing production of high-value-added chemicals, e.g. renewable fuels. Photocatalytic CO2 fixation is one of the strategies where sunlight is used as the sole energy input to drive CO2 reduction into valuable fuels or chemicals. To implement this photocatalytic approach, an efficient catalyst is required to have good selectivity of product formation from the CO2 reduction reaction, while a photosensitizer should be used to harvest solar light and provide photogenerated electrons. As compared to inorganic materials or molecular catalysts, nature's enzymes such as the nickel containing carbon monoxide dehydrogenase (CODH) is a biocatalyst that catalyses the interconversion between CO2 and CO with excellent selectivity and efficiency, thereby motivating studies of its biotechnological application. The fusion of photosensitizers and biocatalysts to facilitate photocatalysis, called photobiocatalysis (also known as semi-artificial photosynthesis or bio-hybrid photocatalysis), has recently gained increased attention, as it opens unexplored opportunities to achieve synergistic effectiveness for the production of desired biofuels. 13-17 To photochemically drive CODH for CO2 reduction into CO, various photosensitizers, have been used, e.g as CdS and CdS/CdSe nanorods, Ru complexes on metal oxide nanoparticles (NPs), Ag nanoclusters tethered to TiO2 NPs or dye-sensitized NiO. The previous photosensitizers have either toxic/precious metals, poor stability or limited light harvesting ability. To address this, in the current work we adapted a biocompatible small organic molecule nanorod photosensitizer based on a phenoxazine chromophore (named POZ-M, see Fig. ) with strong absorption up to 650 nm to efficiently drive the CODH II from Carboxydothermus hydrogenoformans for photocatalytic CO2 reduction into CO. Recently it was emphasized that interaction at the abioticbiotic interface plays a crucial role on the rational design of future biohybrid systems. This motivated us to investigate such interaction in detail within the POZ-M:CODH assembly. For this POZ-M organic NPs have been modified with differently charged surfactants to promote electrostatic interaction with the biological counterpart for CO2 reduction.