This study introduces a multifunctional microcarrier platform integrating enzyme-functionalized microrobots and curcumin-loaded pH-responsive nanocarriers for targeted cancer therapy. We detail the design, fabrication, and functionalization of this hybrid system, highlighting its potential for precise, site-specific cancer treatment. By combining enzyme-loaded Psomes, pH responsive curcumin-loaded Psomes and functionalized microrobots, we have developed an intelligent and efficient drug delivery system for cancer therapy.