Additionally we sought to compare the performance of the Neo4j graph database engine to an alternative one, namely Memgraph . We compared the query execution times on the -/-database configuration. As shown by the results in Figure S??, the Neo4j database engines appears to be faster at all search depths. In short, the performances of the Memgraph and Neo4j graph database engines seem comparable within a factor of 2-3. This experiment demonstrated, how utilizing domain knowledge can pinpoint only a small fraction of nodes (and their associated edges) the elimination of which can be accounted for drastic and statistically significant performance improvement. In fact, the realization of this granted us the breakthrough to meet our preset goal for a performance attributed with high-throughput synthesis design.