The successful application of popular techniques like umbrella sampling and metadynamics depends critically on the proper selection of a reaction coordinate or collective variable (CV). This requires at least some a priori understanding of the system. The CV approach has been extremely successful due to its ability to sample large regions of the configurational space. However, defining a set of CVs that encompasses the entire relevant configurational space is challenging, particularly in large or complex systems. In such cases, the number of necessary CVs can become prohibitively large, resulting in significant computational effort. Additionally, interpreting the configurational space becomes increasingly difficult with numerous CVs.