The measured enantioselectivity was converted into G ‡ using the Gibbs energy equation (G ‡ = -RTln(e.r.)) where T represents the reaction temperature, R denotes the gas constant, and e.r. the enantiomeric ratio collected from each catalytic assay. Using G ‡ as a reaction outcome allowed us to model the differential energy between the minor and major diastereoisomeric pathways involved in the presumed HAT enantiodetermining step.