4. Surface area: Maintaining the surface area of the atomistic models is extremely important in Martini 3, especially with the new small and tiny bead sizes that are able to describe aromatic rings with high detail. After building the initial CG models, the solvent accessible surface area (SASA) was calculated for the atomistic and the CG model (see Figure ). More details regarding the SASA calculations and results are included in Figure of the Supplementary Information.