These results show the complexity of the reaction system with respect to mixing conditions at different flow rates. Yield of the reaction not only depends on reaction rates, but is also influenced by physical conditions such as mixing and solvent physical properties. It was shown in a previous study, that when flow rate from low is increased to high, the flow regime in a T-shape channel will change from segregated flow, vortex regime, engulfment regime and become unsteady, with mixing being improved significantly starting from the engulfment regime. In our case, when the flow rate was increased from 0.00 to 6.00 mL/min, the corresponding Reynolds number ranges from 0 to around 1200 for MeCN and around 1000 for THF (Table ).