Drug-like non-toxic low-nanoMolar affinity top-children have been computationally predicted targeting protein interface cavities on the simplified Vif blue Vif red sA3G ±RNA model . Consensus affinities between DWBEL coevolution and ADV docking co-evolved into two different ~ 3-fold star-like molecular structures. The new consensus top-children cross-docked amino acids on sA3G and Vif-sA3G new and similar to those previously reported for known antiVif drugs, but predicting ~ 10-100 fold higher affinities. These new candidates may offer examples for experimental evaluation of possible HIV inhibitions. Combinatorial chemical synthesis and/or chemical analogues may help to chemically synthesize some of them. Alternatively, different candidates may be evolved by applying similar strategies targeting other interface cavities.