In drug delivery applications, the ability to control the size and stability of micellar aggregates is particularly important. The size of such micelles is one of the most critical features in determining biodistribution and the stability can be tuned to prevent premature release or to enable a controlled release of therapeutics. Ring polymers have shown great promise as potential drug and gene delivery vehicles because they often show improved drug loading and releasing capacity, greater efficacy, longer in vivo circulation times, and high cancer cell uptake as the same polymers with a linear topology.