Alanine can be converted into pyruvate, a crucial intermediate in cellular respiration, through the action of alanine aminotransferase enzyme. Pyruvate can then be utilized in the citric acid cycle to generate ATP, the primary energy currency of cells. Dysregulation of alanine metabolism has been associated with increased cell proliferation and survival in several cancers, and it may contribute to the metabolic rewiring that occurs in cancer cells to meet their increased energy demands. Aspartate metabolism is also implicated in cancer cell proliferation and survival. Aspartate can be converted into oxaloacetate, another intermediate in the citric acid cycle, through the action of aspartate aminotransferase enzyme. Oxaloacetate can then be utilized in the biosynthesis of nucleotides, which are essential for DNA synthesis and cell division. Alterations in aspartate metabolism have been shown to impact cellular energy production, redox balance, and nucleotide synthesis, all of which are critical for cancer cell growth and survival. Glutamate metabolism, on the other hand, has been linked to cancer cell invasion and metastasis.