Still, some cases which correspond to reason (a) may also, perhaps, be statistically-reduced to specific NCIs between PL pairs (as binding specificity to a particular ligand must incorporate some correspondence of this sort). Similarly, reason (b) would indeed push for dynamic modeling as long as considered effects are expected to qualitatively change the very fundamental PL NCI-based correspondence; if that is not the case -there would be no necessary reason to go beyond the static NCI-based picture. Thus, our approach should, in principle, incorporate the above factors -as long as the PL binding process is dominated by the aforementioned NCI-based correspondence. This would clearly not be true for all possible PL binding processes -as may be illustrated using the following simple thought-experiment.