The original high-throughput 3D ED workflow, named SerialRED, was developed on an open source python based software Instamtic . The software is versatile and has been used as a platform for electron crystallography method development. However, expertise and experiences are needed to install and configure the software on different microscope/detector setups. Similar automated data collection software, such as Leginon for MicroED and SerialEM based scripts have also been developed by research groups around the world.