Nimesulide is easily detectable throughout this experiment, pointing out the reusability of the proposed solution, however suffering a steady and linear decrease in recorded current after each cycle. This feature is characteristic of chemisorption and fouling of the electrodes with species contained in the sewage, gradually restricting the available ESA. Notably, the 3DPEC may be effectively regenerated by repeating the activation process. However, a more detailed study should be performed considering the effect of PLA's biodegradability and multiple activations on the 3DPEC's properties.