We assessed the cross-docking performace of AC on as additional data set gathering 76 structures of the SARS-CoV-2 main protease co-crystallised with diverse ligands. The dataset is challenging due to the high solvent exposure and low specificity of the ligands. In re-docking, AC reached a success rate of 59%, versus 45% for GOLD. Cross-docking led to a drop in success rate of roughly 30% for both programs, which is in agreement with what was found in our previous study on non-covalent ligands. Leaving the reactive cysteine or a set of selected active site residues flexible did not improve the results.