Regarding target classes missing bacterial proteins in the published data, now we see the appearance of one bacterial phosphodiesterase, (phospholipase C), two phosphodiesterase's (tyrosine-protein phosphatase YopH and low molecular weight protein-tyrosine phosphatase A), and two primary active transporters (multidrug resistance protein MdtK and protein translocase subunit SecA 1). Typical eukaryotic target classes ("7TM1-3", "Nuclear receptor", "Epigenetic regulator", "VGIC", "LGIC") plus "Electrochemical transporter", "Secreted protein", and "Membrane receptor other" remain unpopulated in bacteria, while the rest of the classes have an increase of the number of proteins. The later also happens with all the target classes of human proteins, with the only exception of 7TM2.