For the SAMPL7 challenge participants were asked to make blind predictions of log 10 P o * /w 1 for the 22 molecules in fig. . We submitted two sets of predictions which used solvation free energies computed using molecular dynamics simulations. In the first set, we treated the octanol-rich phase as pure 1-octanol, and in the second set of calculations we used water-saturated 1-octanol. Following the work of Chen and Siepmann , we used a combination of TIP4P water and TraPPE-UA 1-octanol, with their simulation determined mutual solubility of water in 1-octanol of 0.21 mole fracs. In this way we could be assured the simulation were performed at the equilibrium conditions of the model. Our goal was to understand the effect of water-saturation. Based on the structures of the molecules in SAMPL7 as compared to SAMPL6, we hypothesize that hydrogen bonding plays a more important role in their solvation. Knowing that water-saturated 1-octanol has larger hydrogen bond aggregates as compared to pure 1-octanol, we suspect the effect will be more pronounced in SAMPL7 as compared to SAMPL6. As compared to the experimental data provided at the close of the challenge, our predictions using pure 1-octanol had a RMSE of 1.08 and ranked 1/10 in the "Physical (MM)" category, while our predictions using water-saturated 1-octanol had a RMSE of 1.47 and ranked 6/10 in the Physical (MM) category. After the close of the challenge, we additionally repeated the calculations with TIP4P/2005 to look at the effect of the water model . Overall, we agree that the accuracy of the predictions is sensitive to the choice of force field. However, we additionally find that the inclusion of water is not insignificant. While our predictions here using neat 1-octanol are in better quantitative agreement with experiment, we believe this is a fortuitous result. Moreover, we find that the effect of water saturation is dependent on the chemical structure of the solute.