The regression model by Reith and Müller-Plathe can reliably predict the sign of the Soret coefficient. Furthermore, the magnitude of S RMP T is reasonable, considering the fact that this prediction does not incorporate any temperature or pressure/density dependence. Another drawback of this model is the assumption that there are no coupling effects among the Lennard-Jones mass, size, and energy parameters. However, it has been found that such effects play a non-negligible role for the prediction of thermodiffusion of equimolar Lennard-Jones mixtures .