In a multi-state system after sufficient time, the population of the ligands can be found by a usual thermodynamically Boltzmann weighted distribution. These primary states can be small in number, but with a spread in energy of almost degeneracy; thermal motion of a stable ligand conformation can result in near degenerate energies depending on the ligand and protein. The energy spread about these primary conformational modes can be visualized by physical wiggle room, e.g. spatial perturbations of a bound small molecule coordinates in an almost degenerate but continuous set of states trapped in a well while maintaining boundedness of the ligand. This spread depends on the ligand and protein.