When the emitter tips are narrow enough, each droplet contains on average one or zero analyte molecule, and ion suppression or adduct formation is not as prominent as in high-flow electrospray . Droplet size and droplet initial charge might influence the ion internal energy: larger droplets may travel further down through the source interface and the analytes may be protected from collisions by a solvent shell. That holds if the ions are produced via a charged residue scenario from relatively large droplets.