For the base-promoted hydrolysis of 33 esters and carbamates shown in Figure , the Pearson correlation coefficients between the experimental hydrolysis rates and the QM-calculated or ML-predicted MAA values are 0.84 and 0.78, respectively. This reflects a strong correlation for both methods, although the slope of the regression line for the QM calculations is slightly steeper than for the ML-predicted MAA values, leading to greater separation between data points for the QM-calculated MAA values. All of the ML-predicted MAA values had an estimated error below the predefined cutoff of 30 kJ/mol, thus no outliers were identified.