As the authors of this perspective believe that open and transparent science has strong cascading benefits for the larger scientific community and are most familiar with the GNPS/MassIVE platform (M. , most of the following discussion is contextualized in reference to this resource for untargeted metabolomics analysis. In this context, we discuss the state of spectral libraries for untargeted metabolomics in 2022, describe the essential role of spectral libraries in the development of computational tools, and highlight some open challenges and opportunities for the metabolomics community to address in the coming years.