$170/gram compared to ca. $150,000/gram for Na 15 N3, Figure ) and evaluated under the same reaction conditions (Figure ). Substrates 15 N-27, 15 N-39, 15 N-50, 15 N-54, 15 N-56 and 15 N-62 could be prepared following the same general procedure using 15 N-16 in comparable yields to their non-labeled analogs. Given the versatility of the nitro group to downstream functionalization, it is anticipated that this simple method for 15 Nincorporation will find widespread use. As an example of this, compound 39 in either isotopic form could be converted to the spirocyclic lactam 67, piperidine 68, and amino alcohol 69 under well-precedented conditions (Figure ). In particular, the core scaffold of 67 (1,9-diazaspiro[5.5]undecan-2-one, marked in red), is a biologically important dipiperidine spirocycle used in drug discovery (commercially available for ca. $1100/gram, Sigma-Aldrich). For example, compound 70 bearing this subunit shows good inhibitory activity (IC50 = 14 nM) toward leucine-rich repeat kinase 2 (LRRK2). The simplifying power of alkene hydronitration was further demonstrated on the synthesis of L-evernitrose (5, $1520 /25mg, TargetMol), a naturally occurring nitro sugar found in the antibiotics everninomicins B-D. This unique sugar has stimulated significant interest from the synthetic chemistry community, with five synthetic routes being reported to date, generally requiring 8-15 steps (see SI for a full summary). The shortest of those reported sequences commences with ketosugar 71 (derived in 3 steps from an inexpensive rhamnopyranoside) and requires toxic HCN, LAH, high-pressure Raney-Ni reductive aziridine opening (on 75), and the oxidation of a primary amine to the nitro group. In contrast, the same starting material can be olefinated to 73 using reagent 72, hydronitrated under standard conditions to deliver 74 as a single diastereomer, and hydrolyzed to deliver 5.