The CRN exploration initiated through the reaction of ethene with ozone, with LC-PBE for structures and DLPNO-CCSD(T) for energies, generated 595 compounds and 1350 reactions (Table ). The serial computing time for the CRN-E exploration, that is the time invested in all the calculations of the CRN exploration on a hypothetical single processor core, 34 was 28500 days (Table ). Given that computations are run in parallel, the effective total computing time using an average of 250 cores was 114 days.