To conclude, we have addressed the two-body dissociation of the dications formed after double ionization of E -1,3-butadiene using experimental and theoretical techniques. Our study of the fragmentation of doubly charged butadiene induced by Xe 3+ impact shows the important role of multiple neutral particles (H/H 2 /C 2 H 2 ) emissions. Our results indicate that this emission of neutral particles is the first step towards relaxation for these hot dications. At the experimental time scales, the formation of an unstable and fully naked doubly charged carbon skeleton is observed, which shows complete dehydrogenation of butadiene dication prior to CE. Our theoretical results show that the probability of two-body dissociation with or without emission of neutral particles is strongly de-pendent on the internal energy of these dications. The observation of multiple dissociation channels for dications formed after the loss of neutral fragments is indicative of the involvement of multiple structures, which is possible only with hydrogen migration and hydrogen scrambling. The role of scrambling and roaming processes that are slowing down the fragmentation, prior to direct CE fragmentation dynamics is observed. These processes affect the symmetric and asymmetric bond breaking of the carbon skeleton. To get insight into such complex dynamics, where several different processes with widely varying time scales are active, simulation times of several hundreds of femtoseconds are needed. Such intense dehydrogenation and the formation of a large variety of fragment monocations are expected to significantly alter the chemistry of astrophysical environments containing this molecule.