Since DCC experiments beyond 2-body systems had remained unprecedented, our first goal was to test the hypothesis that the relative stability of ternary complexes induced by DCC-PROTACs could influence their enrichment in templated DCC experiments. For this purpose, we designed and independently synthesized a small set of disulfide-containing Homo-PROTACs containing a DCC handle in their linker moiety, which were assessed regarding their ability to induce ternary complex formation in vitro and degradation of the target protein in cells.