To address these issues with aNCI, we recently proposed the aIGM and amIGM methods, which extend IGM and mIGM to dynamic environment analysis, respectively. In these methods, nonnegligible interfragment interactions are revealed by isosurfaces of averaged 𝛿𝑔 inter ( 𝛿𝑔̅ inter ), which is simply the time average of the 𝛿𝑔 inter calculated for each frame of an MD trajectory. The 𝑠𝑖𝑔𝑛(𝜆 ̅ 2 )𝜌̅ is used to color the isosurfaces of 𝛿𝑔̅ inter , similar to the aNCI method. The only difference between aIGM and amIGM lies in the method used to calculate the grid data for 𝛿𝑔 inter in each considered frame-the former employs IGM, while the latter uses mIGM. We recommend using amIGM over aIGM because the isosurface of aIGM inherits the drawback of IGM: it is too bulgy. Compared with the aNCI method, amIGM has the advantage of visualizing only the average interactions between fragments of interest by properly defining the fragments. Moreover, it has lower requirements for grid quality and can still perform well in cases where aNCI results are poor. Fig. (a) presents a graphical representation of the average interaction between water and phenol in a system containing a phenol molecule dissolved in water, using amIGM. The analysis considered 1000 frames from an MD simulation trajectory.