In the subsequent section, we discuss our coarse-grained homo-oligomer model and the setup of REMD simulations. Then we describe in detail the capabilities of our thermodynamic analysis tools, including heat capacity and free energy of folding calculations, and structural analysis tools, including bonded parameter distributions and native structure determination from structure-based clustering. Next we present the results of scanning the sensitivity of helix stability and cooperativity on sets of bonded and nonbonded parameters. Finally, we discuss future work enabled by the cg_openmm framework, including the potential for discovering novel non-canonical secondary structures, designing stimuli-responsive foldamer systems which transition between multiple stable secondary structures, and gaining a deeper understanding of the principles governing folding through rapid hypothesis testing. Bond-stretching and bond angle-bending potentials are harmonic functions, and torsions are given by a periodic function, in which n is periodicity, k t is the force constant, and φ t is the phase shift. Torsions with a periodicity of 3 represent the familiar rotational energy landscape with 3 minima, typically for gauche+, gauche-, and trans states. A periodicity of 1 corresponds to a single minimum, with φ t being strongly disfavored. Such a potential applied to the backbone beads can favor the formation of helices. At the atomistic level, such asymmetric pseudotorsion potentials could arise from steric interactions amongst neighboring residues. In this work, only periodic torsions with n = 1 are considered. While we have chosen these relatively simple potentials in this initial study, nearly arbitrary custom bonded potential functions may be specified in OpenMM. 38