We also evaluated whether the drug-like compounds possess the appropriate molecular properties necessary for achieving drug efficacy across four datasets, with particular emphasis on Lipinski's Rule of Five. Figure illustrates how drug-like molecules align with the Rule of Five across datasets. This set of guidelines is established to assess the drug likeness of potential pharmaceutical compounds and provides a straightforward approach for predicting the solubility and permeability of compounds based on their molecular properties. We also analyzed the TPSA as a key factor, and most datasets align with the established guidelines.