Evidence strongly suggests that interventions targeting aging can delay and prevent the onset of numerous chronic diseases, potentially extending the healthy lifespan in both adults and older individuals . Recent advancements in modern medicine have led to interventions that address the underlying mechanisms of aging, thereby promoting longevity . These interventions can be broadly categorized into lifestyle changes and pharmaceutical/genetic regulation. Lifestyle changes encompass practices such as caloric restriction and regular physical exercise. In contrast, pharmaceutical/genetic regulation includes a diverse range of chemically unrelated molecules, from natural products and endogenous substances to approved drugs and synthetic compounds. Notable examples include metformin, rapamycin, resveratrol, astaxanthin, curcumin, nordihydroguaiaretic acid, tambulin, and vitamin D, all of which have garnered significant attention for their potential to enhance longevity . Among numerous factors, vitamin D emerges as a significant player in slowing the aging process at the cellular and molecular levels, exhibiting a wide range of actions . As a fat-soluble essential nutrient, vitamin D is crucial for cellular processes such as differentiation, proliferation, and apoptosis . The elevation of calcitriol 2D], the active form of vitamin D stimulates vitamin D nuclear receptors (VDR) throughout the body, triggering the activation of gene transcription . The interaction between 2D] and VDR sites in various produces a multitude of biological actions that impact the potential development of various diseases . These biological actions encompass of calcium and phosphorus in the intestines and bones (osteoporosis), insulin sensitivity and secretion (diabetes), cellular growth and angiogenesis (immune regulation and cancer), expression of renin, and inhibition of vascular smooth muscle proliferation (hypertension and cardiovascular disease), and modulation of inflammation and amyloid plaque formation in the brain (cognitive decline and Alzheimer's disease) .