The NEO-MSMS library can be used directly in the GNPS environment for the different molecular networking analysis. Also, it is available as a set of .mgf files compatible with MZmine3 libraries. oxPUFA files could be used for conducting classical molecular networking analysis with another samples as we demonstrated for serum and algae samples and dereplicate oxylipins. Additionally, the oxPUFA files will also be located in the MASSIVE repository as GNPS dataset allowing their use with GNPS MASST . With this tool, the oxPUFA data can be re-analyzed and used for the annotation of unknowns as putative NEO-PUFA in future lipidomic studies with special value for the novel separation approaches employing sophisticated chiral LC or ion mobility .