To study the BO performance in a MOO context, while also testing multiple molecular representations, the following procedure was used: the homolog scanning strategy was applied to a randomly generated lead peptide with a predicted IC50 ranging from 1 to 20 µM for both alleles (MHC class I A*0101 and A*2602). The peptide sequences were described using either the MAP4 fingerprint (radius of 1 and 4096 bits) or the pretrained ESM-1b pLM fine-tuned using the regular fine-tuning method. During BO, peptide lengths remained fixed.