Drug-target information that was already supplied by the DREAM challenge coordinators was the basis for expanding with pathway connectivity data from sources that have information based upon prior knowledge about target interactions with each other. This collection of diagrams are the pathways found on WikiPathways . Within this collection is information about the connectedness of nodes to form a diagram of biologically related information as seen in Figure . The nodes in the diagram are representations of gene products, metabolites, proteins, and RNA. This connected diagram supplies information about the interactions involved. With the inclusion of interaction information from WikiPathways, information about the direction in which an interaction is directed is also captured. In this case, this is directional information between "gene product" or "protein" nodes. This allows the data nodes that represent gene products or proteins to be found in a one way direction from the node of interest. The pathway data's semantic representation is in the form of the WikiPathways Resource Description Framework . For example, in WikiPathways we have interaction directions that indicate that PI3K activates AKT which in turn inhibits the TSC1/TSC2 dimer in the PI3K pathway (Figure , wikipathways:WP4141), which is an attractive pathway to target in cancer research . What this directional information permits is finding connections to new gene products or proteins at increasing distances. The pathway data used to find target combinations of increasing distance from each other was the WikiPathways RDF . The WikiPathways RDF was used because it contains the semantic information for the pathway diagrams at WikiPathways.org. The RDF being the semantic representation of the nodes, interactions, and metadata associated with the pathways. The WikiPathways RDF specifically captures information about interactions and which elements come before or after another . Because the RDF has this connection information, the WikiPathways RDF makes a logical choice when one wants to traverse a pathway from one point to another. In this case, it would be to look for drugs that share the same pathway or for paths within a pathway that share drug targets.