The integumentary system consists of the skin, hair, nails, and associated glands and serves as a barrier protecting the body from external threats while also playing crucial roles in thermoregulation, sensory perception, immune defense, and metabolic functions. Its intricate structure and function rely on a delicate balance of biochemical and biophysical processes. Pathophysiological conditions affecting this system can disrupt its integrity and lead to a myriad of diseases, including psoriasis, eczema, chronic wounds, and skin cancer. Understanding the transport and transformation of chemical species within this system is vital to elucidating the underlying mechanisms of these disorders and potential treatment approaches to integumentary diseases.