fumigatus (Af 293) (Figure ), and C. albicans (ATCC 60193) (Figure ). The results of the kill kinetic assay revealed the rapid killing action of 15c and 16c against both bacteria and fungi, which was either comparable or even better than the standard antibiotics (Figures 3A1- ). At MIC, both 15c and 16c exerted the complete eradication of MRSA (Figure ) and E. coli (Figure ) in 3-4 h. On the other hand, at 4×MIC both 15c and 16c induced complete neutralization of bacterial burden (MRSA and E. coli) after 2 h of treatment. Moreover, it is important to note that at 4×MIC, both 15c and 16c induced eradication of >85% of MRSA cells after 1 h treatment (Figure ). However, at MIC and 4×MIC, standard antibiotics daptomycin and polymyxin B exerted complete killing of MRSA (Figure ) or E. coli ) in 4-5 h and 3 h, respectively.