The processing of 40,012 reactions, including ITS graph extraction, clustering, and conversion to DPO rules, required approximately 23min on a system equipped with an Intel(R) Core(TM) i7-8700 CPU @ 3.20GHz, featuring 12 CPU and 96 GB of RAM, averaging 34ms per reaction. While this rate is efficient for medium-sized datasets, scaling up to millions of reactions poses significant computational challenges.