The reuse of public data is undergoing a pivotal shift in the metabolomics field, transitioning from single-study analysis to the realm of big data science. This evolution encompasses multiple studies and entire repositories, ideally spanning across diverse repositories. The emergence of public data repositories like MetaboLights 1 (MTBLS), Metabolomics Workbench's National Metabolomics Data Repository (NMDR) , and GNPS/MassIVE 3 , coupled with journal and funding mandates to make data publicly available, has fueled the growth of metabolomics data availability over the past decade.