A set of conformations is generated for the docking ligand and the helper ligands. gnina is used to dock the docking and helper ligands, outputs are sorted by CNNscore. The poses for each ligand are featurized and inter-pose similarities are calculated between all pairs of poses. Finally, the poses for the docking ligand as well as the helper ligands are selected using the Open-ComBind objective function which harnesses the pre-computed similiarity distributions.