After establishing the optimal reaction conditions, the derivative scope of [3+3] annulation reaction was examined with respect to various functional group substituents on the aromatic ring of MBH ketones modified from various esters, along with various 2-aminobenzothiazoles, the results of which are depicted a Reactions were carried out on 0.5 mmol of 1a with 1 equiv of 2a in the 500 µL solvent.