As part of our continuous interest in organofluorine compound synthesis 18 and driven by Martin's 19 and others' 20 elegant work in pro-aromatic dihydroquinazolinone mediated C-C bond cleavage, we assumed that the conversion of ketones into pro-aromatic dihydroquinazolinones might be suited for gem-difluoroalkene construction with general ketones. If successful, such an approach would not only provide a novel disconnection in retrosynthetic analysis of gemdifluoroalkens, but also represent a worthwhile effort for chemical invention in the field of C-C bond activation. 21 Scheme 1. gem-Difluoroalkene-containing bioactive molecules and gem-difluoroalkene construction via C(sp 3 )-C bond activation.