Manidipine was predicted to be a promising binder to M pro in a virtual screen using Glide SP, AutoDock Vina, and two protocols with AutoDock 4.2 followed by MD simulation using Gromacs . Tipranavir has been identified as a potential SARS-CoV-2 inhibitor in in vitro screens. No other computational studies have predicted tipranavir to be a helicase inhibitor. Kumar et al. reported potential activity against M pro using docking with MD simulation , whereas Gul et al., using a similar approach, suggested tipranavir would have activity of against both M pro and RdRp . Autodock Vina was also used by Mohamed et al. to identify tipranavir as a potential inhibitor of SARS-CoV-2 PL pro 10 .