The Virus BioResistor (VBR) is an innovative biosensor that can detect small protein disease markers in human urine within one minute with high sensitivity and precision. The VBR uses engineered virus particles as receptors to selectively bind the protein of interest, which are entrained in a conductive PEDOT channel. The sensitivity of VBRs is inversely related to the molecular weight of the protein target, and large proteins, such as IgG antibodies, cannot be detected even at high concentrations. To address this limitation, the PEDOT channel of the VBR is subjected to a simple electrochemical process called potentiostatic overoxidation, which reduces the conductivity of the polymeric channel. The resulting biosensors, known as O VBRs, exhibit enhanced sensitivity to both small and large proteins. For instance, two undetectable antibodies at normal VBRs can be detected using O VBRs with a limit of detection of 40 ng/mL and a dynamic range for quantitation extending to 600 ng/mL. The increased sensitivity of O 2 VBRs is likely due to the strong and disproportionate increase in resistance of the PEDOT-PSS base layer of the channel relative to the virus-PEDOT sensing layer. However, the study does not exclude the possibility of the influence of significant morphological changes caused by the oxidation process on sensitivity, such as increased porosity or mean pore diameter of the virus-PEDOT layer. The SEM and AFM images show significant changes in the topography of the virus-PEDOT layer caused by overoxidation, but it is uncertain if they affect the ability of large proteins to permeate the layer. In conclusion, the Virus BioResistor is an excellent biosensor for detecting small protein disease markers, and the O 2 VBRs with enhanced sensitivity offer a promising approach to detecting larger proteins such as antibodies. The electrochemical process of potentiostatic overoxidation can dramatically increase the sensitivity of the VBRs, and further studies are needed to explore the mechanism and morphological changes caused by this process.