From the previous results, we selected five derivatives, namely 5a, 5e, 5i, 5m, and 7, to evaluate human liver microsomal (HLM) stability. These candidates were chosen based on several criteria: (i) the highest inhibition of AChE (5i), BChE (7 and 5m); (ii) the highest LLE values ( ); (iii) and the lowest cytotoxicity (5a, 5e, and 7). Despite its high LLE value, compound 5g was excluded from further testing due to the structural liability. It is well-documented that the methoxy group is metabolically unstable, particularly in (hetero)aryl methyl ethers, where the primary metabolic pathway involves Odemethylation, often followed by glucuronidation .