Autonomous Scanning Electron Microscope (updated on Nov 10, 2023) With the GPT-4V released on Nov 6, 2023, we are able to achieve an exampling prototype of the instrument coach discussed in the outlook, the autonomous Scanning Electron Microscope (SEM). SEM is one of the most commonly used characterization instruments in natural science research. A standard SEM may require a dedicated room for placement and come with hundreds of pages of detailed operation manuals. This leads to a high learning cost, including its working principles and mastering operational skills. However, for most scientific researchers, these learning costs may become less necessary in the upcoming AI era. In the near future, researchers will only need to describe the kind of SEM image they need in natural language, similar to what is demonstrated in this demo video. Once the researcher states the final objective, no further intervention is required. The AI will independently iterate and eventually deliver a satisfactory SEM image.