We have simulated collagen networks with an increasingly complex array of combined defects to examine how this affects rupturing behaviour. Introducing edge removal defects showed that the flexibility in a network is critical in preventing damage, but there is a balancing factor where the networks weaken when too many edges are removed. We found that network flexibility is critical in preventing damage, although a network with too few links is weak and damages easily. Further, we introduced complicated defects such as the Stone-Wales defect representing a misplaced molecule, and combining that with edge removal defects. This showed that the flexibility around a defect would not prevent an existing rupture from propagating.