As noted previously, the linear regression model trained here has an added benefit of interpretability. Figure contains an analysis of simulations of fructose in varying cosolvent/water mixtures, all at the same cosolvent/water weight ratio (90%/10%). Figure illustrates the differences in water topology that occurs when the chemistry of the cosolvent is altered. We focus on two particular cosolvents: THF and DMSO. For fructose, the change in reaction rate is highest when in a DMSO/water mixture (σ = 1.7) and lowest when in a THF/water mixture (σ = 0.8). We note that this corresponds with large changes in the topology of the water density. In THF, water is agglomerated in large clusters near the reactant, which reduces the total number of topological features in the water density function (e.g., connected component, holes, voids) and dampens the magnitude of the peaks and valleys in the EC curve, which is consistent with the findings of Chew and co-workers. The sublevel sets at points in the filtration are also illustrated (Figure ), further confirming this result. The opposite holds true for water in DMSO, here we see a larger number of high-density and low-density areas on our manifold increasing the peak and valley magnitude of the EC curve. This indicates that DMSO is interrupting the interactions between water molecules and reducing the total amount of water molecules near fructose. This behavior can increase selectivity of the acid-catalyzed reaction of fructose, where the shielding of subsequent products (e.g., 5-hydroxymethylfurfural) inhibits the formation of undesired products (e.g., levulinic acid) as shown in the findings by Mushrif and co-workers. Figure : EC curves for fructose solvated in different cosolvent/water mixtures along with the representative submanifolds during various points in the filtration. Each of the curves are computed with a 90 wt% cosolvent, 10 wt% water solution. Many of the simulations (ACN, DIO, GVL) behave similarly from a topological perspective, and each have a similar impact on the reactivity of fructose. The EC curves for THF and DMSO differ from the EC curves of the previously mentioned solvents. DMSO interrupts waterwater interactions resulting in a larger number of high and low density areas, which manifests in an increased number of connected components, holes, and voids in the density field captured by the EC curve. The opposite occurs with THF where we see fewer, but larger, clusters of high and low density water; this suggests that THF increases the interactions between water molecules and causes larger clusters of water to form.