Taken together, our results show that synthetic DNA has great potential as a building block for creating artificial nanoscale molecular motors that can self-propel in fluids. In addition, thanks to the use of enzymes, biologically available and biocompatible fuels can be used as a source of self-propulsion. We believe that the results reported here will pave the way to more sophisticated designs of DNA-based enzyme-powered motors, where synthetic DNA can lead to the discovery of new structural designs and allow programmable control of the decoration of enzymes and other biomolecules on their surfaces. The above properties, together with the sequence specificity of the DNA-DNA interactions, may enable the construction of enzyme-driven DNA motors that can respond to different substrates in the same solution and perform different motion dynamics in a fuel-dependent manner, paving the way for new approaches to understanding nanoscale motion and enabling better control over the design and functionality of nano/micro-swimmers.