For pathogen infections, early diagnosis and precise treatment are essential to cut the mortality rate. At present, different technologies or methods have been developed for either fundamental research of pathogen or clinical diagnosis of pathogenic microbes, including Gram staining methods, electron microscopy (SEM, TEM, Cryo-EM), and microcolony method . However, these techniques generally depend on expensive instruments, which also suffer the drawbacks of complicated operation, high cost, and labor-intensive and time-consuming process. On the other hand, clinical treatment aims to effectively elimination of pathogens after diagnosis. Unfortunately, due to the abuse of anti-pathogen drugs (especially antibiotics), the drug-resistant pathogenic infection has become a serious global public health issue .