Finally, we used PSIPRED version 2.0, which is based on neural networks to predict the ordinary states of protein secondary structure , included in the PHYRE2 protein tertiary structure prediction suite available at: . bio.ic.ac.uk/~phyre2/html/page.cgi?id=index. Although version 4.0 of PSIPRED is available as a web server at , it only allows secondary structure prediction of one sequence at a time, so it was unfeasible to use it with our dataset.