Analysis of non-covalent interaction components. A detailed characterization of the physical interactions in ligand-pocket systems is needed to both aid understanding and ensuring diversity in the coverage of interactions. To that end, a decomposition of E int of QUID systems with SAPT analysis was performed, specifically with the sSAPT0 version due to its good balance between accuracy and computational cost . The sSAPT0 E int predictions for the equilibrium dimers were found qualitatively consistent with those computed at the LNO-CCSD(T) level (MAE of 0.85 kcal/mol). The SAPT analysis provides insight into the energy components of the NCIs, namely induction, dispersion, electrostatic, and exchange contributions, which elucidates the balance of intermolecular interactions. Such a measure of the dispersion and electrostatic components has been used before to gain insight into specific protein-ligand interactions and will provide a solid basis for interpreting the differing predictions of E int from different QM methods.