Cannabis has a rich history of both medicinal and recrea`onal use across various cultures globally. However, modern scien`fic explora`on into cannabis began in the 19th century, and its poten`al medicinal uses have gained significant ahen`on in recent years. Legaliza`on of cannabis has seen a diverse approach across the globe.(1) Countries that have legalized medical use of cannabis include Australia, Czech Republic, Denmark, Germany, Israel, New Zealand, the United Kingdom, any many more. Places that have legalized cannabis for recrea`onal use include Canada, Mexico,(2) Thailand, and Uruguay, plus 24 states, 3 territories, and the District of Columbia in the United States. Such legalisa`ons have led to the development of a broad spectrum of cannabis products including dry flowers, edibles, and oil products. This shil in policy reflects diverse cultural, legal, and poli`cal environments, and has necessitated stringent quality control and safety measures for cannabis products. Different countries and USA states have established various guidelines and regula`ons for cannabis tes`ng.(3) These guidelines typically require the tes`ng for contaminants like pes`cides, toxic elements, mycotoxins, and pathogens, and may also include checks for residual solvents in cannabis oil products. The development of appropriate analy`cal methods to meet these guidelines is crucial for quality control and consumer safety. In this the cannabis industry faces significant challenges in achieving accurate analy`cal test results due to various factors, including sampling issues, sample prepara`on, cross contamina`on, and the analy`cal methods used.