Using self-assembly from triangular pyridine ligand 1,3,5tris-[(4-pyridyl)ethynyl]benzene with [(R)-(+)-BINAP]Pd II / Pt II bis (triflates), Stang and colleagues first demonstrated the discrete chiral three-dimensional M6L4-type MOCs with Tsymmetry (MOC-1) in the year 1997. Notably, the absence of four faces removes the usual C4 and inversion center (i) needed for a regular octahedron with Oh space group; additionally, the chiral Pd II or Pt II metal corners also preclude the presence of mirror planes in order for Td space group. Consequently, T space group with well-defined chirality features is afforded to MOC-1 (Figure ) granted by the reserved 4C3 + 3I4 symmetry, and other chiral polyhedra with D3, I or O symmetry can also be realized from the same starting materials. Using a similar approach, the Fujita group has achieved the incorporation of chirality into the periphery of their well-known ''panelling" M6L4-type MOCs by substituting the ethylenediamine capping ligands with chiral diamine auxiliaries on the Pd(II) corners. 66 Wang and colleagues pioneered the diastereoselective synthesis of heterometallic enantiopure chiral cubic cages in 2015. They accomplished this by combining heterotopic ligands with stereomeric or racemic amines used in situ with Zn II and Pd II ions concurrently to produce heteronuclear cubic cages (MOC-2-3, Figure ). The chirality of the C* centers in the chiral amines can be transferred to all the Zn(II) vertices, resulting in the formation of O-symmetric homochiral cubic cages (MOC-2). On the other hand, the achiral amines lead to the formation of racemic assemblies of MOC-3.