In summary, our results highlight the value of the covalent docking method implemented in AC and its usefulness for drug design studies. To increase its user friendliness, we created a suit of tools to handle the setup of non-covalent complexes on a large scale, which will be available in the next update of the SwissParam 52 web server, to be released within the next months. In a second step, AC will be made freely accessible through a new version of the SwissDock webserver.