CVT requires one to choose a reaction path, and the MEP in isoinertial (i.e., mass-scaled) coordinates is often sufficiently accurate for calculating over-barrier contributions to the rates. However, care needs to be taken to ensure that the MEP is calculated over a long enough path to include the variational transition state and that an accurate enough generalized normal mode analysis is made, which is complicated by the usual need to use a curvilinear-coordinate analysis. Furthermore, an accurate estimate of tunneling contributions usually requires an even wider range of the reaction path. Thus, the computational procedure of CVT/MT involves construction of a reaction path and generalized-normalmode PFs over a range wide enough to include the variational transition state and the portion of the barrier through which appreciable tunneling occurs. Moreover, to obtain accurate results with highly anharmonic transition structures, one often needs to calculate SRP scale factors, 113 which adds further complexity to the process. In contrast, even without the CVT optimization of the transition state location and without a semiclassical tunneling coefficient, the new CNEO-TST method can accurately predict the HAT rate constants at room temperature, although the results may be slightly worse at higher and lower temperatures. This performance of CNEO-TST is especially striking when compared to CTST. Although CNEO-TST may still face challenges in the low-temperature deep tunneling regime, it has high promise as an inexpensive and black-box method for applications to more complex chemical and biological systems at room temperature.