SAS maps are based on systematic pairwise comparisons of the compounds in a data set. A general schematic representation of a SAS map is presented in Figure . SAS maps generated in this study represented all 13,533 pairwise comparisons between the 165 peptides of the dataset. The map calculated structure similarity with the MAP4 fingerprint and the MinHashed distance function proposed by Capecchi et al , represented on the X-axis. The activity difference (i.e., the difference between them and the pMIC 50 values of the pair of peptides) was plotted on the Y-axis. The molecular weight differences between each pair of peptides are plotted on the Z-axis.