Regarding bioinformatics, docking uses a computer to show the binding between a small binding molecule and a large protein to get a read on the binding conditions at the active site . First, it finds the protein's binding pocket, which it then uses to compute the algorithms of different molecule orientations . The computer then reads the various configurations and analyzes the probability of each, ranking them in order of most likely to least likely. Nucleolin protein, found in the nucleolus, is involved in many DNA and RNA functions. It is also between the shuttle between the cytoplasm and the nucleus. The protein is sent to the cell surface in many cancers as part of cell signaling. It has been suggested as a viable biomarker in detecting and targeting cancer.