Considering the structural parameters, the shape of nanoparticles is the factor affecting the release of drugs from nanocarriers. From the academic point of view, the global shape of particles is considered the structural criterion for nanoparticles; otherwise, it is strongly questioned whether the appearing structures are nanoparticles or not. In any case, this parameter comes into play only in the production of capsules for therapeutic purposes. In the production of capsules, the powder of the nanocarriers must "flow" homogeneously into each capsule. In other words, the amount of powder (and thus the amount of drug) in the capsules must be exactly right. As for the production process, this is where it gets complicated. This homogeneity can only be achieved if the nanocarriers have a spherical shape. Otherwise, the homogeneity of the dose of the encapsulated drug would be compromised. For intravenous formulations and injections, a solution of nanocarriers purified by dialysis could be used directly for the formulation, bypassing the preparation step described above. Thus, the problem with the shape of the nanoparticles is only a problem for oral formulations.