The mitochondrial outer membrane transport complex Sam37 (IPR019564) is a part of the SAM or TOB complex, which is in charge of sorting the mitochondrial outer membrane. It is necessary for the sorting of proteins with a complex topology, such as β-barrel proteins, to the mitochondrial outer membrane following their import by the TOM complex. It shares homology with Metaxin-1, which is also a component of the mitochondrial outer membrane β-barrel protein transport complex. The human disease protein Swiss:O60220 contains Tim10-like (PF02953) domains. Members of this family, including Tim9 and Tim10, facilitate mitochondrial protein import. It seems that the mitochondrial intermembrane space is the location of the members of this family.