Next, a time distribution comparison for each major step in the workflow was done using SP query and comparing all database configurations. The results are shown in Figure S??, in SI. Differences between individual steps can span orders of magnitudes which contributes to the overall statistically significant difference observed between total processing query execution times. Notably, the best performance was observed on the -/-configuration (see Figure ). These results are striking, considering that only 1.24% and 1.08% of the reaction and substance nodes were removed, respectively, as compared to the +/+ database configuration (see Table ). The Table ?? and ?? shows the total time for the entire workflow. Steps related to converting json into networkx was omitted from the time distribution plot but is accounted for in the total time table.