For quality control and therapeutic efficacy, it is imperative that the concentration of betamethasone 17-valerate in these creams be determined precisely. To assure the safety and efficacy of topical dermatological medicinal products, quality control requires extensive and high-level analytical support . Distinct liquid chromatographic techniques have been documented for the assessment of betamethasone 17-valerate either independently or in conjunction with other ingredients in various formulations (USP 41, NF36