In summary, we have shown that metal complexes have promise as antifungal agents, displaying hit-rates that vastly surpass those of a similarly sourced set of organic molecules. While metal compounds did show somewhat higher rates of toxicity, they are overall still 14x times more likely to be active against C. albicans or C. neoformans in our dataset. We further showed that this activity is generally retained against other fungal species and strains, including drug-resistant isolates. Lastly, we demonstrate that most of these metal complexes are well tolerated by G. mellonella, displaying no signs of toxicity, and we identify one compound, Pt1 with the ability to significantly reduce the load of C. albicans in a moth larvae infection model.