The core results of this showcase analysis comparing the most frequent NP and drug molecule scaffolds (i.e. commonness of benzene, oxygen as the dominant hetero atom in NP, nitrogen in drug molecules) are in general agreement with similar studies . A significantly higher prevalence of aromatic scaffolds in drug molecules as opposed to NP that most of these studies report cannot be observed here. This stresses that the results presented here are only a proof of concept for the application of Scaffold Generator. A more detailed analysis would first of all need an extensive data curation pipeline to standardise input molecules or filter or mark duplicates between the two data sets. Furthermore, a more extensive analysis of physicochemical property distributions in the extracted scaffolds could be conducted.