Simulations #1 to #4 are examples of the intra-organelle SMACdriven stabilization. On the other hand, simulations #5 and #6 constitute an counterexample, showing that the amount of intraorganelle SMACs is only a necessary condition for fusion pore stabilization, which becomes sufficient when steady SMAC:lipid contacts are able to establish (simulations #1 to #4). Overall, for different amounts of intra-organelle SMACs (4, 8, 12 and 24) the fusion pore is stabilized in terms of its life-time, if and only if effective contacts exist between the SMACs and the lipid bilayers.