This selection corresponded to 6,406 (0.87 %) of the 735,078 possible drug pairs in the FDA set, 8,932 (0.79 %) of the 1,124,250 possible drug pairs in the EGFR set, and 8,464 (22.63 %) of the 37,401 possible drug pairs in the PMB set. Each drug was represented in the selected pairs between 1 and 193 times in the FDA approved set, between 1 and 870 times in the EGFR set, and between 4 and 1,031 times in the PMB set (Figure ). Compared to the exhaustive list of drug pairs, the selected drug pairs were enriched in high similarity pairs with lower values of Jaccard distance (dJ).