The chemical structure and synthetic route of TPA-2 are presented in Scheme 1. Before testing, the compound was purified by column chromatography and temperaturegradient vacuum sublimation. The structure of TPA-2 was characterized by 1 H NMR and C NMR (vide Fig. , Fig. and Fig. ). The emission maxima of TPA-2 in toluene solution is greater than 600 nm and ΔEST of TPA-2 is 0.07 eV, indicating that TPA-2 can be used as a red-TADF OLED material (Fig. and Table ). The thermal properties of TPA-2 were determined by differential scanning calorimetry (DSC) and thermogravimetric analysis (TGA) under a nitrogen atmosphere. A (Tg) of 411 K (138 °C ) and (Td) of 697 K (424 °C) were observed (Fig. ), in good agreement with the predicted values by machine learning. The predicted Tg value is 426 K, demonstrating an error of 15 K, while the predicted Td value is 738 K, demonstrating an error of 41 K. As expected, the TPA-2 compound has good thermal stability. These results show that it is feasible to apply our ML models to predict the thermal stability of unknown OLED materials. Our ML models could be served as a useful tool to quickly screen high thermal stability OLED materials.