It is noteworthy that nigrosporin A (164) and fusaquinon A (166) were also evaluated in another study for their antimalarial, anti-mycobacterial, antibacterial, and cytotoxic activity. Both compounds showed no antimalarial, antibacterial, or anti-mycobacterial activity, whereas they showed selective cytotoxicity . Nigrosporin A (164) displayed weak cytotoxic activity against the MCF-7 cell line with an IC50 value of 110.36 μM and good cytotoxicity against NCI-H187 cell line with IC50 value of 13.69 μM, while fusaquinon A (166) exhibited weak cytotoxicity against both human cancer cells, MCF-7, and monkey kidney cells, Vero cells with IC50 value of 84.38 and 44.46 μM, respectively. Also, fusaquinon A (166) displayed potent cytotoxicity against the NCI-H187 cell line with an IC50 value of 7.32 μM . Another bioactive anthraquinone derivative isolated from mangrove-derived fungus Fusarium sp.