Infection with Zika virus (ZIKV) results in neuronal cell death . Infection with the Zika virus (ZIKV) can result in significant neurological disorders in adults, including Guillain-Barré syndrome . Zika virus infection during pregnancy can result in severe birth malformations and congenital Zika syndrome , including microcephaly(4), brain abnormalities, and other major birth problems . ZIKV infection in the brain has the potential to damage oligodendrocyte development and myelination . ZIKV causes microcephaly and other neurological abnormalities in developing fetuses when it infects human fetal astrocytes (HFA) . Mitochondrial rupture and potential mitochondrial membrane damage have been seen following ZIKV infection in human neural stem cells and SNB-19 glioblastoma cell lines. Abnormal mitochondrial rupture contributes to the neuronal cell death caused by ZIKV . This condition may be explained by the dysregulated expression of genes and signaling pathways involved in neurogenesis and neuron formation . At the moment, no anti-ZIKV reagent has been approved for clinical use. Investigating how the Zika virus infects brain cells will aid in the development of vaccinations and medicines.