A significant advancement in electronic integrated circuits history was the invention of fieldprogrammable gate arrays (FPGAs), semiconductor devices enabling post-manufacturing reprogramming of integrated circuits. FPGAs consist of logic blocks arranged in a grid and linked by customizable routing paths, akin to programming software, facilitating the creation of custom circuits. Inspired by silicon-based FPGAs, researchers have recently developed DNA-based programmable gate arrays (DPGAs) with high scalability. They showcased a practical application of DNA integrated circuits (DICs) by reconfiguring and programming multilayer DPGAs to design a quadratic equation-solving DIC. This liquid computer could run more than 100 billion distinct circuits. Additionally, to demonstrate the clinical significance of DICs, the researchers tackled a crucial issue related to molecular circuits for identifying disease-associated biomarkers. They developed a nonlinear classifier essential for tasks such as decision trees and clustering. Their system successfully distinguished between healthy and diseased samples, accurately identifying all 23 samples tested within about two hours . This grants DNA drug carriers diagnostic capabilities far surpassing those of conventional designs, solely reliant on stimuli-responsiveness. Through this approach, DNA carriers can accurately pinpoint tumor sites by discerning and differentiating them from healthy tissues through computational means.