To a solution of 2-nitrobenzyl bromide (1.00 g, 4.75 mmol) in MeOH (15 mL), 2,4-dimethoxybenzylamine (2.00 g, 9.50 mmol) and DIPEA (2.45 g, 19.0 mmol) were added dropwise. The solution was stirred at 25 °C for 18 h. Water (8 mL) and KOH (1.00 g, 19.0 mmol) were then added and the mixture was stirred at 60 ºC for 24 h. Then, water (50 mL) was added and MeOH was removed under reduced pressure. Water was then added and the mixture was extracted three times with CH2Cl2.