Liver cancer was one of the top five causes of cancer death in 185 countries in 2020, with an estimated 906,000 new cases and 830,000 deaths globally. The number of liver cancer deaths is precited to reach approximately 1.3 million people by 2040 (56.4% more than in 2020) , whilst the number of new cases of liver cancer per year is estimated to increase by 55% between 2020 and 2040, with a possible 1.4 million people diagnosed in 2040. Liver cancer is caused by viral infections including hepatitis B virus (HBV), hepatitis C virus (HCV), and hepatitis D virus (HDV), and is becoming one of the most challenging and urgent problems in Vietnam today. An estimated 25,000 new cases of liver cancer were reported in 2020, making Vietnam the fifth highest country in the world for incidence [2] . Since 2018, liver cancer has risen above lung cancer to become the leading cause of cancer death in Vietnam [2] .