One of the advantages of the ensemble approach is that it substantially improves sampling in order to control uncertainties efficiently without adding to the wall clock time to solution. The entire ABFE protocol (minimum, standard or further extended) can be performed in the same amount of wall clock time as required for a single simulation by executing all replicas concurrently. With modern supercomputing hardware, it is not uncommon to achieve a performance of around 200 ns/day using a single GPU for typical protein-ligand systems. Therefore, it is possible to run the full protocol in less than two hours. The only requirement is the availability of sufficient resources. In fact, we performed around 150 ABFE EQ calculations using our standard protocol within a few hours on Summit (Oak Ridge National Laboratory) in November 2021 when we had access to the full machine for 36 hours. Given that our ensemble approach is embarrasingly parallelisable on larger machines, we are able to perform thousands of such calculations on the world's first exascale machine, Frontier, within the same time frame.