We prepared six formulations up to 250 mL, a scale-up factor x25 in volume vs. the experiments conducted on the pH robot. This is closer to industrial formulation development tasks. We adjusted the formulations to pH 5.8 ± 0.2 using 0.5 M citric acid/0.5 M sodium hydroxide following the suggestions from the titration algorithm web application. Table presents the results of these titrations. The scale-up experiments were carried out as a benchtop titration, similar to traditional pH adjustment experiments in industrial research and development (R&D) laboratories. The setup is detailed in the materials and methods section.