Enzyme immobilization is a prerequisite to envisage recovery and reuse. Immobilization usually tends to enhance enzyme stability and tolerance to organic solvents, and to allow for the use of different reactor configurations , which are key features industrial processes. It also paves the way to the integration of enzymes within heterogeneous catalysts, forming so-called hybrid chemo-enzymatic catalysts that are excellent candidates to run intensified cascade reactions . A potential downside of enzyme immobilization is that enzymatic activity may -in some cases -be decreased through the immobilization process (due to active site blockage, for example). Nevertheless, free enzymes can also experience activity reduction over time due to heat and mechanical stresses during extended biocatalytic processes 120 .