The D1 receptor-mediated effects of THC are also thought to rely on Fos expression. For example, (Miyamoto et al., 1996) showed that in dorsomedial striatum and nucleus accumbens, SCH 23390 blocked Fos expression induced by THC . Similarly, Lazenka et al. (2005) show that before administration of THC, treating with D1 receptor antagonists can attenuate Δ FBJ murine osteosarcoma viral oncogene homolog B (ΔFosB), a protein part of Fos family with a transcription function, in the in the prefrontal cortex, amygdala, caudate-putamen, and nucleus accumbens. Additionally, the study suggests that SCH 23390 inhibited ΔFosB expression that is THC-stimulated, but it induced ΔFosB expression in nucleus accumbens, which might be due to 5-HT2R, a serotonin receptor which modulates monoaminergic transmission, mood, motor behavior, appetite and endocrine secretion 10 , activity .