We separated the above search results of Zika E-related ion channel domains (Table ). Zika E possesses B30.2/SPRY and Ion_trans domains, as shown in Table . B30.2/SPRY (IPR001870) is a calcium channel subunit present in the ryanodine receptor. The ion_trans (IPR005821, PFAM: PF00520) domain is present in sodium, potassium, and calcium ion channel proteins. This domain is duplicated numerous times in some Na or K channel proteins. Both B30.2/SPRY A and Ion_trans A are placed near the N-terminal to E. E's N-terminal is involved in receptor binding. Ion_trans B-C could have a role in membrane fusion. It implies that Ca2+ is involved in the receptor binding and membrane fusion of the Zika E.