The Me3N•SO3 complex has also found use in the preparation of sulfamates which contain polar functional groups that are significant to a wide range of biological functions, including viral infection and protein-protein interaction. The sulfamation reaction of benzylamine derivatives were carried out using Me3N•SO3 complex under a low reaction temperature (30-60 °C) affording the corresponding trimethylammonium cation. This was subsequently exchanged with a more lipophilic counterion, tributylamine, then exchanged with sodium salt leading to the formation of sulfamates (Scheme 7) and employed in other examples. Scheme 7. The sulfamation reaction of benzylamine derivatives using Me3N•SO3 in a combination with the lipophilic counterion (Bu3N) and a sodium exchange strategy.