The widespread application of CSIC approach is facilitated by the availability of reagents and the ease of obtaining them from commercially available compounds, e.g. amino and hydroxy acids, corresponding nitriles, etc. Thus, CSIC reaction has become the primary method for obtaining 4-amino-2,3-dihydroisothiazole-1,1-dioxides (enaminosultams) from cyanosulfonamides (Scheme 6). As it was mentioned above, these compounds have a great potential for biological activity, making them intriguing candidates for drug development. Scheme 6. CSIC reactions (intramolecular Thorpe condensation ) for the synthesis of enaminosultams