A simulation of SENSAT for a larger parameter space exemplifies the potential for optimized nanosensors (Figure ). It shows that depending on affinities (Kd values) amplification by multiple orders of magnitude is possible for the pure enzyme products (Figure ). In enzymatic reaction conditions this is also possible (Figure ) even though our current implementation of SWCNTs-based sensors did only show smaller amplification factors. Simulated enhancement factor for the whole enzymatic reaction. Note that some parameters from figure have been used (TMB as substrate (100 µM), C30-SWCNT sensors (0.5 nM), stopped after 30 min). The grey reference lines in both plots represent the experimentally determined values. Note that the signal amplification is restricted by the sensor saturation at high concentrations and the lower limit of the sensor.