1c has the same N-substituent as 1b, but a shorter 3-atom-long linker. The trans configuration of 1c, similarly to 1b, is the favored one in terms of both Glide SP docking score and Emodel score, and reproduces the two halogen bonds of the tail (Fig. ), whereas these halogen bonds are absent for the cis configuration, in which the 3,4-dichlorophenyl is also in subpocket C (Fig. ). 1c has better van der Waals energy (-50.2 vs. -47.0 kcal/mol) and worse internal energy (11.6 vs. 16.8 kcal/mol) in the trans than cis configuration, whereas the electrostatic component is comparable. In the trans pose, the N-cyclopropyl is in con-tact with the sidechains of Leu209, Met213 and Trp221 (pose 1, Fig. ), while in the cis configuration, it contacts the sidechain of Phe97 (pose 2, Fig. ).