I will demonstrate that the hitlist produced by QFVina is significantly different from the one produced by Vina, and similarly, the hitlist generated by QFVinardo is markedly different from that of Vinardo. This observation alone supports the validity of the QFVina and QFVinardo methods, as QM conformations are much more realistic than those generated by flexible ligand docking programs. If these differences in conformations lead to significant variations in the final hitlists, it suggests that QM conformation-based docking is also likely to be more accurate in most cases.