In this work, we used atomistic molecular dynamics simulations to investigate the heat transfer through nanoscale gold-water interfaces. We simulated four nanoscale-gold surfaces with differing curvature, subjected to various heating intensities, and under two wetting conditions. An analysis of the critical value of the thermal interface conductance confirmed that the thermal interface conductance is an important factor in the aqueous heat transfer of particles in the size range we investigated. We found that for a given AuNP size, the thermal interface conductance increased non-linearly with the applied heat flux under moderate wetting of the gold surface, and did not change under poor wetting conditions. Analysis of the gold and water vibrational density of states showed a temperature dependent shift in the water distribution that improved the overlap with the gold density of states. This shift in the water VDOS may contribute to the increases in thermal interface conductance with applied heat flux under the moderate wetting condition. Our results also showed that the thermal interface conductance between nanoscale-gold and water increased linearly with interface curvature at both low and high heat flux under both wetting conditions. Our analysis indicated that the curvature dependence of the interface conductance coincided with a curvature dependent increase in water adsorption at the gold surfaces, consistent with that observed previously with a simpler model of solid nanospheres immersed in monoatomic fluid. This work helps elucidate the temperature and curvature effects on the thermal conductance across nanoscale gold-water interfaces. Our work here focused on bare spherical particles immersed in water. Although we considered two conditions for the gold wettability which approximates the effect of coating the gold with ligands of different hydrophilicity, there are additional effects that ligand functionalization can have on interfacial heat transfer that were not directly accounted for in our study. We also did not directly investigate how the observed temperature and curvature dependent changes in the thermal interface conductance impact the spatiotemporal temperature dynamics during pulsed laser stimulation of AuNPs, or how they might affect any particular applications of photothermally heated AuNPs. Future work will be required to address these issues, as well as to experimentally validate our findings. Initially, each nanoscale gold-water system was energy minimized and then equilibrated under NVT conditions for 1 ns at 300 K, followed by an additional equilibration phase under NPT conditions for 1 ns at 300 K and 1 atm. The non-equilibrium steady-state simulations were carried out under NPH conditions at 1 atm. The gold structure was subjected to continuous heating at a given heat power Q, distributed uniformly across the gold atoms. In order to create a non-equilibrium heat flux an outer region of water was maintained at 300 K with a Langevin thermostat, serving as a heat sink. In the planar gold-water system, the heat sink was defined as the region encompassing z > 200 Å and z < -200 Å within the unit cell; note that these two regions are joined into a single region by the periodic boundary conditions. In the AuNP systems, the heat sink region was defined using a radial distance criterion, namely the region encompassing r > 65 Å, r > 85 Å, and r > 110 Å from the origin, for the 3, 5, and 10 nm AuNPs, respectively. The non-equilibrium steady-state simulations were run for 2, 3, 4 and 6 ns, for the 3, 5, and 10 nm AuNPs and planar slab, respectively. For the poor wetting case, the simulation times were all 4 ns.