Recent advances in nanotechnology have introduced aluminium and potassium nanoparticles as promising antimicrobial agents due to their unique physicochemical properties. These nanoparticles exhibit broad-spectrum antibacterial activity against Gram-positive and Gram-negative bacteria through mechanisms such as oxidative stress induction, cell membrane disruption, and inhibition of protein synthesis . Studies have demonstrated that aluminium nanoparticles effectively inhibit pathogens like Escherichia coli and Staphylococcus aureus, with reported minimum inhibitory concentration (MIC) values as low as 10 µg/mL . The potential of nanoparticles to bypass conventional antibiotic resistance mechanisms makes them a valuable tool in combating drug-resistant bacterial infections . The aqueous extract of Polyalthia longifolia has emerged as a natural, eco-friendly resource for synthesizing nanoparticles. Rich in phytochemicals, the extract acts as a reducing and stabilizing agent for the synthesis of metal nanoparticles, including aluminium and potassium . These greensynthesized nanoparticles have demonstrated potent antibacterial activity, with MIC values as low as 0.039 mg/mL against Staphylococcus aureus, along with significant zones of inhibition against pathogens such as Escherichia coli and Klebsiella pneumoniae . Given the rising threat of AMR, exploring the synergistic potential of plant-based nanoparticle synthesis in conjunction with their antimicrobial properties offers promising avenues for developing sustainable and effective therapeutic strategies.