The chromosome replication initiator DnaA C-terminal (IPR013159) reports that the C-terminal domain of the bacterial DnaA protein is very important for starting chromosome replication and keeping it under control. DnaA is a protein that binds to DNA and ATP. It specifically binds to the dnaA box, a 9 bp nucleotide repeat sequence that is present in the chromosome replication origin (oriC). Two conserved regions make up DnaA: the first is located in the N-terminal half, corresponding to the ATP binding domain, and the second is located in the C-terminal half, potentially involving DNA binding.