MetaModels were used to globally fit lgK 11 and δ H AB to the data of hepes-01, hepes-02 and hepes-03 from the pytc-demo that are followed by Monte Carlo simulation to estimate the confidence intervals. These results were then compared to the confidence intervals obtained from Monte Carlo simulations for the individual experiments. The obtained parameters and the confidence intervals using Monte Carlo simulation (σ MC = SE y , 5000 steps) are listed in Table . While the globally estimated lgK 11 is nearly the mean of the individual models (7.595), the IPR for lgK 11 can not be approximated by the mean of the individual IPR (0.065). The same holds true for the enthalpy of complexation, where the average parameter is -4.621 kcal/mol and the average IPR is 0.057. The estimated parameters from pytc and SupraFit are the same.