Notably, the highest mean tumor growth inhibition on day 30 was for the molecules generated in the maximize potency-only scenario. This indicates that a mean loss of potency is not compensated by higher drug exposure (lower clearance or higher volume of distribution) for this case study. However, it is difficult to draw quantitative conclusions from the current framework. Firstly, the QSP model predictions add additional uncertainty on top of the QSPR parameter predictions. Secondly, the allometric scaling also adds an uncertain amount of error to these predictions. This further confirms the need of classifying the uncertainty of each prediction.