To draw a direct comparison to other kinds of catalysts, we constructed a volcano plot for catalytic activity (Figure ). This volcano plot is essentially a specific pair plot analogous to As seen in Figure and Figure , both derivatization and the structure of the carbon-nitrogen scaffold around the active site can significantly affect catalytic activity. Although significant, the effect of both factors on the reactions 𝑅 → R -O # H and 𝑅 → R -OH is strongly correlated. To a small extent, the change in active site between C-1 and C-2 exhibits a small deviation from this scaling relation, along with a handful of derivatives of C-1, for which the effects of derivatization are significantly more pronounced than all the other GCCs.