With the inclusion of larger molecules and molecules that contain multiple functional groups, the increase in overall error of the liquid properties is to be expected if we consider the accuracy on a per functional group basis. This effect is exemplified by the case of o-chloroaniline, which has unsigned errors in ∆H vap of 2.61 kcal/mol and in ∆G hyd of 3.49 kcal/mol. By way of comparison, the smaller molecules aniline and chlorobenzene showed unsigned errors in ∆H vap of 1.63 and 1.17 kcal/mol and in ∆G hyd of 2.66 and 1.67 kcal/mol, respectively. This should be kept in mind when applying QUBE (and other force fields) to the study of, for example, absolute protein-ligand binding free energies for larger organic molecules containing multiple functional groups.