In this restrospective study, we are interested in using computational methods to identify binding modes for fragments which bind to a protein called soluble epoxide hydrolase (SEH). SEH has been hypothesized to have therapeutic potential in cardiovascular diseases, inflammatory diseases, and neurological diseases, which has spurred efforts in developing SEH inhibitors. Specifically, SEH is involved in the breakdown of epoxyeicosatrienoic acids (EETs), acids with cardiovascular effects such as vasodilation and anti-inflammatory actions.