Until this stage, the experiments confirmed the impact of the milling action on the sublimation speed of solids and the possibility of utilizing the setup to fine regulate the parameters to a have a linear and controllable evolution of sublimate allowing to further investigate the effect of other factors. The possibility of selecting different types of protons (e.g. aliphatic or aromatic) of both the analytes and the internal standard for the quantification highlighted the wide applicability of the approach to different substrates and, eventually, also different nuclei. Along the same lines, the Spinsolve® solvent suppression protocol allowed using nondeuterated DMSO as NMR solvent in all the experiments and, virtually, applying any liquid as sublimate trap.