In the current study, assess the efficacity of Celastrol on cell viability of SH-SY5Y neuroblastoma cells (Fig. ). The cells were treated with 20 to 200 µM Celastrol for 24 hrs and have not significantly affected the viability of neuroblastoma cells (Fig. ). Further, in the present study we have examined the toxic effect of rotenone with MTT as shown in Fig.