Dynamic combinatorial chemistry (DCC) is a powerful approach to generate chemically complex compound libraries with applications ranging from drug discovery to supramolecular chemistry. Conceptually, DCC exploits a reversible reaction to form compound libraries (dynamic combinatorial libraries, DCLs) from constituting building blocks under thermodynamic control. The position of the equilibrium of this reversible reaction can be biased by addition of an interacting target macromolecule acting as template. Reversibly assembled library members that bind to that template will be thermodynamically stabilized, hence enriched in abundance in templated libraries. These stabilized library members can be identified and ranked by their enrichment in templated libraries when compared to the corresponding nontemplated blank libraries (Figure ).