The electrodeposited silver nanodendrites consisted of a high density of metallic nanostructures with associated nanogaps. It was found that the 2D nanodendrites were strongly attached to the silicon surface of the sensor chip and did not lift off when washed or used in aqueous test solutions. By contrast, the 3D structures were found to detach easily from the surface of the chip and were not studied further.). Initial Raman experiments showed that the as fabricated silver nanodendrites could support plasmonic hot spots and therefore could be attractive for SERS applications. In order to test their SERS capabilities, a monolayer of Raman reporter 4-Aminobenzothiol (4ABT) was deposited on the nanodendrites surface, and its Raman response recorded and compared to the that obtained from bulk 4-ABT; under the same experimental conditions, see Figure . The peak assignment can be found in SI. As can be seen, the Raman signal is significantly higher for the monolayer than it is for the solid confirming a SERS response. The enhancement factor (EF) was then calculated using the following equation :