Genhenden and co-workers tested AiZynthFinder on a set of 497 diverse molecules, against the ASKCOS synthesis planning software. Comparisons between the two methods proved difficult, due to ill-defined metrics for route comparisons. Thus, our results were initially benchmarked against a 2023 publication that utilized AiZynthFinder to investigate the effects of varied hyperparameters for multi-step synthesis on a dataset of 50,000 (50K) randomly sampled molecules from the ChEMBL database. For consistency, we used the same dataset for primary testing of our enhancements.