We refer to a previous study for fruitful recent developments in this area. Finally, AMUSET-TICA offers an efficient way to compute the Koopman matrix at a specific lag time. This capability positions AMUSET-TICA as a promising tool in the future for computing Koopman matrices at various lag times, which can be used as inputs for the Generalized Master Equation and other non-Markovian dynamical models for biomolecular dynamics.