Despite this problem long having been recognized by the hardware manufacturers, incorporation of a needle-washing contingency prior to injection has proved only to be truly effective in terms of preventing cross-contamination rather than clogging. Several other techniques have been proposed to alleviate this critical problem, such as placing additional efforts on sample preparation or incorporating additional hardware such as a pump and valve to back-flush the LC . A number of techniques exploit solid-phase extraction, in-line filtration/back-flushing or a combination thereof . A number of these approaches require the purchase of an additional pump as well as changes to the existing set-up such as re-configuration of the valves to enable back-flush . An alternative method to decrease the rate of clogging involves modification of the gradients used to increase the solubility of samples, which are not typically soluble in aqueous-based systems , though this approach creates significant additional work for the analytical chemistry team with the need to create custom chromatography conditions for each project based on the diversity of the chemical substrates under investigation,. Increasing the sample and column temperature has also been utilized to increase solubility, but this again is not a universal solution particularly as compounds can still crash when they encounter "cold spots" within the system, and in some cases the elevated temperatures the sample encounters can lead to compound decomposition . Given that none of the solutions considered so far have been either universal or cost-effective, we report here our progress towards the design, validation, and implementation of a simple, inexpensive and automated method for heterogeneous sample analysis on LCMS whilst negating the need for extensive manipulation of the sample prior to analysis.