Having completed the synthesis of BocPP and APPCN, we next tried the asymmetric Michael reaction with reference to Type 2 chiral reaction 20 in Fig. . If the asymmetric Michael reaction proceeds, subsequent cyclization would then form hemiacetal, which could be reduced by NaBH4 to give 3. However, it was found that this reaction condition did not give the desired product but gave a complex mixture., Fig. . Since the reaction was messy at the first Michael addition step, it was considered that the side reaction occurred due to the high reactivity of the aldehyde moiety of BocPP.