We have previously implemented generic detection of SCs on a range of physical matrices in an ultraportable, handheld device. Here, we report the development of a device that can extract e-liquid from suspicious e-cigarettes through artificial actuation and simultaneous deposition onto a solid matrix. We couple this novel extraction method with our previously reported generic detection to inform on SC content of sealed e-cigarettes rapidly and non-destructively. Building on this, we also detail a novel method for detection and discrimination of THC and nitazenes in sealed e-cigarettes using photochemical degradation on a solid matrix. We anticipate this field-portable device will be deployed as an effective harm reduction measure in the hands of trained school-staff, community support workers and as part of community drug checking services.