Haemolymph plays a fundamental role in arthropod immunity by providing the first line of defense against bacterial, fungal, and viral infections. The remarkable diversity and adaptability of invertebrates suggest that their innate immune mechanisms are highly effective. Research indicates that haemolymph has antimicrobial, antifungal, and anticancer properties . Given its potential, this study aims to assess the prophylactic efficacy of haemolymph from selected arthropods in preventing trypanosomiasis.