General Procedure D. To a solution of carboxylic acid (1.0 eq.) in DMF (7.7 mL/mmol) was added DIPEA (4.0 eq.). HATU (1.1 eq.) was then added, and the reaction was stirred at r.t. for 5 min. VH032-amine ( synthesised according to literature 16, 21 ), Me-VH032-amine (58, synthesised according to literature 29 ) or cis-Me-VH032-amine (88, synthesised according to literature 29 ) (1.1 eq.) was then added and the reaction left to stir at r. The acid chloride intermediate (1.5 -3 eq.) was re-dissolved in anhydrous DCM (9.6 mL/mmol) and added to a N2 purged flask containing alcohol (1.0 eq., from Step 1). Anhydrous DIPEA was added (3.0 -5.0 eq., or until pH 9.0) and left to stir at r.t. for 16 h. The mixtures were then concentrated in vacuo and the residues were purified by HPLC.