These advancements provide deeper insights into the complex multi-step process of paclitaxel biosynthesis and open new avenues for its **biotechnological production**, potentially making the supply of this important chemotherapeutic agent more sustainable and cost-effective. 02) A novel step towards the heterologous biosynthesis of paclitaxel-Characterization of T1βOH taxane hydroxylase. Escrich, A., et al. The paper presents significant advancements in understanding and engineering the biosynthesis of paclitaxel, a vital anticancer drug, through heterologous production systems. Specifically, it focuses on the characterization of a previously uncharacterized enzyme, T1βOH taxane hydroxylase, which plays a crucial role in the oxygenation steps of the paclitaxel biosynthetic pathway.