It has been speculated that intrinsically disordered sequence regions can facilitate molecular interactions and recognition through dynamically sampling a large spatial region and therefore increasing the probability of encounter, a process dubbed flycasting . In the case of α-synuclein, it has been proposed that monomers are recruited to the fibril end through interactions with the fuzzy-coat . Our finding that removal of the fuzzy coat does not inhibit the elongation rate of fibrils indicates that the fuzzy coat of α-synuclein fibrils does not play a significant role in recruitment of monomers to the fibril end.