Promiscuity could take any of several forms. A promiscuous ligand could simply be highly conforming to a protein surface's geometry, with a high number of hydrogen donors & acceptors to more likely "stick" nonspecifically to any given protein site's own set of h-donors and h-acceptors. Another mechanism sees promiscuous inhibition take the form of colloidal aggregations. In this mechanism, upon reaching a certain concentration, the ligand forms tightly-packed spherical aggregates with itself, even inside the cell. Proteins and enzymes non-specifically bind to the surface of the aggregation and are inhibited in the process. Often seen as a nuisance originally, it is now also seen as a source of opportunity in drug discovery as well. Deliberate study of aggregation in cell-based assays is a nascent sub-field 91 so cataloguing of non-specific aggregation among polyphenols in cells merits further investigation. Quercetin has earned a reputation as a promiscuous inhibitor as well as having served as one of the first aggregators identified. Luteolin 93 , curcumin , myricetin and tannic acid are also promiscuous inhibitors, where myricetin and tannic acid have been further identified as aggregators. Of 123,844 assay records hosted by Pubchem and compiled by Gilberg et al. (2016) , their isolation of the most promiscuous 466 of them (99.6% percentile) contains 13 polyphenols based on our cheminformatic-oriented definition.