The important advantage to highlight with the T1-T2* MR measurement is the ability to undertake analysis of the reaction in the milling container. We consider analysis in the milling container, even when removed from the shaker apparatus, to be an in situ measurement. The synthesis of ZIF-8 served as our example (figure ). The reaction was milled in a small lab-made Teflon jar with two small zirconia balls. These materials, Teflon and zirconia, have minimal hydrogen content yielding minimal background signal. This allows the reaction to be milled and analysed without ever having to open the milling vessel. The measurements of (a) zinc oxide, (b) 2-methylimidazole, and (c) zinc acetate dihydrate, all employed a zoomed scale compared to the display scale for the reaction to reveal low amplitude background signal. The plots of (d) reactants pre-milling, (e) ZIF-8 as synthesized and (f) ZIF-8 purified, all contained the same amount of material and therefore, the same quantity of hydrogen. The plots have variable scaling to better reveal low signal.