w Figure : Left: Binding free energies of (PA) 1 (w) 0-5 (blue), (LA) 1 (w) 0-5 (red), (ProA) 1 (w) 0-5 (purple), and (diol) 1 (w) 0-5 (orange) at 298.15 K with the binding free energies of pure water clusters at the given level of theory included as a black dashed line. Right: Equilibrium hydrate distributions of the various organic acids and the water reference at 298.15 K and 1 atm and at 100% relative humidity.