It is therefore clear that more studies are needed to decipher how the composition can affect all these properties. More importantly, on many occasions, these studies are performed only in organic solvents, overlooking the influence that the water transference protocols can have on the final composition and the magnetic properties, which may lead to partial or erroneous interpretations. Soriano et al ., reported Mn 2+ leaching and thus, composition changes after water transference by using meso-2,3dimercaptosuccinic acid (DMSA) and dopamine (DOPA) ligands. Cation leaching during cobalt ferrite water transference by silica coating was associated with affected performance as MRI contrast agents . Similarly, the leaching of Mn 2+ ions might alter the crystal structure of the MNPs, significantly affecting their magnetic properties.