Overall, only weak correlations of the individual properties with T. brucei inhibition were observed (Pearson R: 0.47-0.55 and -0.41 --0.54; computed as defined in the SI). The strongest correlation was found for the predicted skin permeability, QPlogKp, as a descriptor linked to lipophilicity, (R: 0.55). The logPo/w and the binding to human serum albumin had slightly weaker correlations with the anti-parasitic effect (R: 0.49 and 0.47, respectively). For these properties, an increase in the value corresponds with higher anti-T. brucei activity. In contrast, some properties showed anti-correlation, for instance, the aqueous solubility and the cohesive index (R: -0.54 and -0.41, respectively). Taken together, the data indicate an improved anti-parasitic effect with increased lipophilicity of the studied compounds.