The present work addresses this gap by introducing a modeling framework for representing coverage-dependent thermophysical properties, including both enthalpy and entropy. This framework is implemented in Cantera , which is an open-source microkinetic modeling software package for continuum-level simulations of reactor models and reactive flow. As part of the effort to demonstrate Cantera's capabilities, a secondary aim of the present work is to evaluate the effect of coverage on the vibrational entropy of adsorbates. Two model systems of importance to many catalytic processes are used, CO adsorbed on Pt(111) (e.g. emission oxidation chemistry) and Co(0001) (e.g. Fischer-Tropsch synthesis). First, we analyze the coverage-dependent shifts in vibrational frequencies in all modes, including low-frequency modes. Our analysis provides a more complete picture of the coverage-dependent vibrational frequency shifts on top of the prior experimental investigations and how this relates to the entropy of adsorbates. Second, we compare this change in entropy to the well-established coverage effect on the enthalpy of adsorbates in meanfield microkinetic models. The combined analysis provides a holistic understanding of the impact of vibrational entropic lateral interactions against the impact of enthalpic lateral interactions.