Using the final DE-FF valence and non-bonded parameter sets, we tested the accuracy on the Sage condensed phase bench- mark set, which comprises 284 transfer free energies between aqueous and non-aqueous media (Section 4.3). This transfer of molecules between solvents of different polarities is expected to be a good surrogate for the accuracy of force fields for proteinligand binding applications. Figure shows the correlation between experimental and computed transfer free energies for the DE-FF. The RMS error is just 0.85 0.97 0.76 kcal/mol, which compares favourably with the Sage force field for the same dataset (RMSE 1.08 0.99 kcal/mol). Full statistics and comparisons between the force fields are provided in Section S3.