Extrapolations to T CutPNO → 0 using Eq. ( ) are shown in Fig. . Here, we compare L/N and N/T extrapolations using both the MP2 and the CCSD(T) thresholds, although all calculations are performed at the RI-MP2/cc-pVDZ level. Using MP2 thresholds, both extrapolation schemes reduce the DLPNO errors below 0.5 kcal/mol in every single case, even for the siz- The S12L complexes present a similar story as shown by the DLPNO errors in Fig. , which were again computed at the RI-MP2/cc-pVDZ level. (Similar errors are obtained at the RI-MP2/def2-SVP level; see Fig. .) Errors are large for thresholds less conservative than loose-MP2, suggesting in particular that the CCSD(T) thresholds may not be appropriate for benchmark calculations in systems of this size. Normal-and tight-MP2 thresholds afford MAEs of 0.7 kcal/mol and 0.2 kcal/mol, respectively, with maximum DLPNO errors of 2.6 kcal/mol (normal-MP2) and 1.0 kcal/mol (tight-MP2). The largest errors arise in the dispersion-bound systems 4a and 4b, which are complexes of C C 60 H 28 . 103 Even for these challenging cases, however, setting T CutPNO ≤ 10 -8 affords an interaction energy that is very close the canonical RI-MP2 value. Extrapolated results for S12L are presented in Fig. . For L/N and N/T extrapolation using MP2 thresholds, the errors are uniformly < 0.6 kcal/mol even for the challenging 4a and 4b cases. Thus, benchmark-quality results are obtainable for dispersion-bound systems of this size, but only when tight thresholds are combined with extrapolation. Extrapolation based on the less conservative CCSD(T) thresholds is somewhat less accurate, especially for the difficult 4a and 4b complexes, where DLPNO[(N/T) CCSD(T) ] extrapolation leaves residual errors of about 4 kcal/mol. For each of the other S12L complexes, the DLPNO[(N/T) CCSD(T) ] error is < 1 kcal/mol. Looking ahead to DLPNO-CCSD(T) calcu-lations, it would seem that benchmark-quality results are only obtainable using tight-CCSD(T) thresholds. Even then, large dispersion-bound complexes may be problematic.