Consensus top-children ADV blind-docking surrounding the whole Vif blue Vif red sA3G ±RNA molecule were performed using 60x60x60 Å grids. Their predicted docking-cavities were analysed by PyMol (Figure ). Numbers, consensus top-children selected to study their targeted amino acids (Figure ) Red, docking to Vif red +sA3G cavities. Blue, docking to Vif blue +sA3G cavities (Figure ). Gray, docking to cavities behind sA3G (Figure ). ▲, Vif8-derived consensus top-children. The ADV blind-docking affinities of the consensus top-children were then compared after targeting Vif blue Vif red sA3G ± RNA (Figure ). In the absence of RNA, the highest affinities were predicted for Vif8 consensus top-children number 6 (Figure , blue circle) and for star30 consensus top-children number 26 (Figure , red circle). In the presence of RNA, the highest affinities were predicted for 119 (Figure , red triangle) and for 32 (Figure , red circle). Some consensus topchildren increased their affinities when in the presence of RNA (i.e., 119, 432, 32, 40), while others maintained (i.e., 189, 337, 1, 43, 45) or reduced (6, 26) their affinities.