Glycans are comprised of individual monosaccharides that are capable of modifying diverse biomolecules such as lipids and proteins. Additionally, glycans can exist as unconjugated free polysaccharides. Glycosylation processes in nature are comprised of a wide range of monosaccharides and their derivatives, numbering in at least the hundreds . There are a variety of methods that have been employed to detect and measure glycans, however mass spectrometry (MS) has become the method of choice for rapid characterisation of sample glycosylation . The ability to separate glycans by mass for mass-based detection provides a relatively unbiased approach to detecting both the usual and unusual glycans in nature.