Currently, the design of methods for the efficient synthesis of new biologically active substances poses a challenge due to the need to adapt the developed method to the principles of green chemistry and sustainable development and prevent waste production, while maintaining the cost-effectiveness of the process, the possibility of scale-up and the possibility of obtaining the desired substances of high purity. The significant scale of this problem is illustrated by the amount of the environmental factor (E-factor, i.e., the ratio of the mass of waste per mass of product). Typical values of this indicator for the processes of obtaining pharmaceuticals and fine chemicals are in the range from 5 to 100 , which shows the problem associated with the significant amount of waste generated by the above-mentioned chemical industries. In the course of multistage synthesis of compounds with often complex chemical structures, technological problems also cause side reactions that result in impurities that are difficult to separate without chromatographic methods.