According to the exponential approximation for the COCONUT subset of 40,000 NP structures, a scaffold network of up to 456,000 NP molecules could still be constructed in a single day using Scaffold Generator. The measured runtime for the complete COCONUT database of 395,450 compounds with less than 11 rings was 16.5 h (5 h for the construction of a scaffold forest). This is below the runtime of 19.2 h expected for this data set size according to the exponential function approximating the scaling behaviour of the COCONUT subset network generation. The underlying effect can be that with growing size of the network, less new scaffolds need to be integrated per newly added molecule. Here, one also has to take into account that the subset used for the performance and scaling snapshot was compiled using a diversity-preserving method . This may have increased the effect even further.