While the RANK-RANKL-OPG and Wnt pathways are key regulators of the bone remodeling cycle, other cytokines modulate these signals and bone cell activity. Despite this, there is a distinct lack of variety in the cytokines considered in mathematical formulations of bone remodeling. Table shows that only three cytokines aside from RANK-RANKL-OPG and TGF-β are explicted modeled: IL-6, MCSF, and IGF. One benefit of including other cytokines in bone models is the potential to explore their importance under various remodeling conditions, yet many models with cytokines lack this analysis.