In this study, we generated a benchmark set of strained non-equilibrium conformers of organic small molecules and assessed the ability of various computational methods to predict the relative energies of these conformers. At a high level, the conclusions are straightforward: very good performance is possible on this test set, but high-quality DFT functionals and large basis sets must be employed. Reducing the complexity of the functional or the size of the basis set leads to increased errors, and different balances between speed and accuracy can be achieved with various combinations of method, basis set, and corrections. While some variant of this conclusion is to be expected from any DFT benchmarking paper, we feel that the small size and considerable difficulty of Wiggle150 makes it a valuable addition to the computational chemistry canon, and we anticipate that this benchmark will prove useful in guiding the creation of future generations of density functionals and NNPs.