The OpenFF Initiative seeks to improve force fields via a series of progressive improvements, thus we focus on the SMIRNOFF force field in particular in order to help our work with OpenFF. Specifically, we identify molecules where parameterization dif-ferences in SMIRNOFF relative to other force fields lead to geometry differences. Molecules that yielded four difference flags from combinations including the SMIRNOFF-minimized conformer, and six similarity flags from combinations not including the SMIRNOFF-minimized conformer, were likewise grouped into a set of interest. We refer to this set as the Individually Different SMIRNOFF ( ) set. This set contained 93,859 molecules in total, or 3.48% of all molecules included in this analysis.