We developed the Interdisciplinary Science Program in Research and Entrepreneurship (INSPIRE) as an intensive, hands-on introduction to the role of interdisciplinary biophysical and biochemical techniques in drug discovery, as well as a crash-course in entrepreneurship and innovation. INSPIRE consisted of a four-week summer curriculum including modules on: bioinformatics, fragment-based drug discovery, protein expression and purification, biophysical assays, the pharmaceutical industry, and an introduction to innovation and entrepreneurship.