The interaction and solvation free energies between the ligand and the proteins were computed with MMPBSA.py . The solvation energies of the individual molecules, binary complexes, and ternary complexes in Figure were calculated with the molecular mechanics Poisson-Boltzmann surface area (MMPB/SA) method using MMPBSA.py. As the induced PPIs do not include the conformational change of the free protein, it is possible to directly evaluate its strength using a single-trajectory approximation, neglecting the binary entropy contribution,