The m 1 A modification, unlike the Ψ, m 5 C and m 6 A modifications, disrupts hydrogen bonding of canonic base pair, which is the A-U base pair in this case. Therefore, it is not surprising that it has a more dramatic effect on the catalytic activity of SC2RC, although polymerases such as TGIRT have been reported to be able to readthrough m 1 A with high efficiency. Because the m 1 A modification may completely block SC2RC, if an individual's epitranscriptomic machinery could install m 1 A onto the viral genome, which is not impossible given that many modifications have been detected in viruses, it may provide a means, in addition to others such as induced immunity, for the individual to eliminate the virus or reduce its capability to replicate. Thus, the specific individual would be asymptomatic or less symptomatic toward COVID-19. However, for this speculation to be true, in addition to the actual existence of the modification in the SARS-CoV-2 genome, the modification must not be removed by demethylation enzymes such as ALKBH3 and FTO in the host cells before viral genome replication by SC2RC takes place.