While integrating the NORMAN-SLE content into PubChem 6 , it became clear that the number of chemicals within PubChem (115 million chemicals, June 2023) that could satisfy the 2021 OECD PFAS definition dwarfed the several thousand entries in the common PFAS suspect lists. A simple substructure search for "CF 2 " revealed millions of potential matches in PubChem. Since new PFAS are emerging very rapidly, the need for a manageable, relevant, rapidly updateable open collection of PFAS for the community is increasingly obvious. This article describes efforts to develop an interactive, open, dynamic, browsable collection of PFAS content in PubChem to serve this purpose.