The tertiary structure analysis of the isolate SARS-CoV-2 _HKU-SZ-001_2020 ORF1ab polyprotein is given in Table . It is seen that the polyprotein has a 98.94 percent identity with PDB structure 6nur.1.A which is a hetero-1-2-1-mer. The polyprotein is an RNA directed RNA polymerase. The protein is identical to the SARS-Coronavirus NSP12 bound to NSP7 and NSP8 co-factors . In SARS it is basically a nonstructural protein with NSP12 being the RNA dependent RNA polymerase and the co factors NSP 7 and NSP 8 having the function of forming hexadecameric complexes and also act as processivity clamp for RNA polymerase and primase . This structure as in SARS CoV here in SARS-CoV-2 may be involved in the machinery of core RNA synthesis and can be a template for exploring antiviral properties.