The total number of unique scaffolds for the 187 compounds was 90. Figure shows the ten most frequent chemical scaffolds, along with the frequency and percent proportion, which represent 35.54% of the total distribution. The most frequent scaffolds were benzene (10.37%), followed by flavone (5.93%) and flavylium (2.96%). Other frequent scaffolds were indole (2.96%), pyridine (2.22%), hexane (2.22%), and isoflavone (1.48%). Figure shows the cyclic system recovery (CSR) curve for the scaffold diversity in the Epi Food Chemical Database. This curve illustrates the proportion of molecules within a dataset that belong to a specific fraction of scaffolds. In a dataset with high diversity, each molecule in the library would correspond to a different scaffold, resulting in a diagonal with an area under the curve (AUC) of 0.5. As the range of scaffold diversity diminishes, the curve will deviate from the diagonal orientation. Otherwise, the nadir of diversity would show in a dataset wherein all compounds share the same chemical scaffold; in such an instance, the CSR curve would appear as a vertical line, accompanied by an AUC of 1.0. The shape of the CSR curve in Figure indicates a large scaffold diversity of the Epi Food Chemical Database, with an AUC of 0.75.