For the re-activation list, DOPHOH and DOPHUN are enantiomorphs, composed of large cages connected by channels, 17 so, they displayed equivalent mechanical properties, and that is why their points are overlapping as shown in Figure . The two enantiomorphs failed the direct activation as well as the freeze-drying approach. Next, QIYDIN01, also named TCM-4′, is an interpenetrated structure. As well, difficulties were encountered during the activation of QYIDIN01 despite a two stages solvent-exchange process -with acetone and dichloromethane -was adopted. Whereas, MUNDEG, also named JLU-Liu16, is composed of two different metal-nodes; copper paddlewheels and copper-iodine metal clusters. However, the structure failed at the activation stage and was not stable in many organic solvents.