Sublingual or buccal drug delivery approaches have gained increasing attention due to the fast and direct drug uptake in the oral cavity. The sublingual route is known to be one of the most effective ones, as the drug is directly absorbed by the high number of capillaries below the tongue and effectively brought to the blood circulation. Additionally, sublingual drugdelivery systems are designed for the drug to avoid passing the gastrointestinal tract, reducing potential side effects of the drugs observed with common peroral delivery, such as gastrointestinal ulceration, and limitations of local acidic conditions, as well as enzymatic degradation. Furthermore, these approaches simplify the uptake of the drugs, as they avoid potential swallowing difficulties improving patient compliance.