UNIFAC is a group contribution-based method, and in general is able to cover a wider range of chemical compound space. Nonetheless, some parameters are still missing from the parameter matrix. Recently, it has likewise been demonstrated how electronic structure calculations, specifically COSMO-based (conductor-like screening model) calculations, can be used to predict missing UNIFAC parameters . So while the SMx universal solvent models, MOSCED, and UNIFAC are all limited in the system they can treat, there is opportunity for synergy among the methods.