The complexity objection A key concern of self-microfabrication is its complexity, notably its need for developmental knowledge in non-model species. Some complex problems require equally complex solutions and may justify why material-producing organoids challenge the "Keep It Simple, Stupid" principle. Even with a simple example, Ashby's law of requisite variety demonstrates that a certain level of complexity is required to regulate a variety of disturbances 609 . Interest in biological materials stems from their capacity to collectively optimize multiple criteria that simpler synthetic methods struggle to solve ; including recyclability, raw material abundance, high mechanical performance, use of aqueous solvents, non-harmful chemicals and room temperature synthesis . Organoids could even simplify the manufacturing of complex systems by leveraging emergence and self-organization 607 , as discussed in the previous section with the high-dev low-tech approach.