SHXF has been applied to a large variety of molecular systems to predict their nonadiabatic behavior upon photoexcitation. Min and workers studied the photoinduced isomerizations of the trans-penta-2,4-dieniminium cation 250 and the ring-opening in cyclohexa-1,3-diene 251 , they worked on a class of molecular rotary motors that utilize the fulgide motif , and they simulated the primary steps of the photodynamics of cyclopropanone 254 . These simulations have been performed using the PyUNIxMD code , mainly in combination with spin-restricted ensemble-referenced Kohn-Sham method , that allows for a proper characterization of the conical intersections with the ground state. It is worth mentioning, however, that Min proposed recently an interesting generalization of the exact factorization and of SHXF such that the electronic evolution equation accommodates for a hermitian formulation in terms of the electronic density. With this proposition, the photodynamics of ethylene was studied employing real-time time-dependent density functional theory .