A low-density system comprising 400 n-C 720 H 1442 chains was prepared, and heated from 10 K to 500 K over 2 million time steps (∼41 ns) under isochoric conditions. A 50 million time step (∼204 ns) isobaric-isothermal closed (NPT) simulation was then performed with set points of 1 atm and 500 K to pressurize the system. The system was subsequently simulated under NPT conditions at 1 atm and 500 K for 200 million time steps (∼4.1 µs) followed by a 200 million time step (∼4.1 µs) NVT simulation at 500 K. A 1.2 billion time step (∼24.4 µs) NVT simulation at 500 K was then performed, and it was verified post hoc that the n-C 720 H 1442 melt was in equilibrium during the simulation (see Supplementary Online Material).