Finally, the topologies involve 2-to-1 mappings of non-hydrogen atoms to CG beads and contain "tiny" beads. The standard Martini 3 parameters of the "tiny" beads restrict the time step ∆t to well below 30 fs. While we did not encounter any crashes during the explicit simulations of the above systems, caution must be taken when other molecules with "tiny" beads are present.