As these experiments require natural 13 C isotope abundance, the price to pay relative to previous selective 2DJ experiments is sensitivity. SERFBIRD partly compensates for this by making optimal use of both 1 H and 13 C thermal polarizations and by real-time BIRD homodecoupling. The latter does not only improve signal intensity by collapsing the multiplet to a singlet, but it also delivers much shorter experimental times than interferogram-based pure shift experiments. SERF or G-SERF experiments can also be combined with real-time homodecoupling, 5b,10b but line broadening due to relaxation losses between data chunks can be significant when long selective pulses are required. In contrast, real-time 13 C BIRD homodecoupling usually does not lead to dramatic line broadening. 22b When sensitivity allows and methine protons need to be observed, SERFBIRD thus could be an attractive faster alternative to PSYCHEDELIC or G-SERF even when strong coupling complications do not play. In contrast, the SATASERF experiment is less sensitive, typically delivers just one coupling per experiment, and when pure shift is needed, it will usually have to resort to the slower interferogram acquisition. The optimal strategy to measure couplings on 13 C satellites would be to measure on methine protons using SERFBIRD as much as possible and switch to SATASERF only when measurements on methylene protons are unavoidable.