The current study aims to model, via molecular docking, the binding energy and types of interactions of the Sars-Cov2 protein and ACE2 in human bodies shown in sketch with the aforementioned antiviral medications, some of which are potentially tested by pharmaceuticals companies and newly suggested candidates, including natural products. Searching for more potent natural anti-COVID19 drugs is very demanding. . Medicinal plants, especially those employed in traditional Chinese medicine, have attracted significant attention because they include bioactive compounds that could be used to develop legal drugs against several diseases with no or minimal risks . We have chosen Flavonoid quercetin, an antioxidant and signaling molecule, and an effective Zinc ionophore . Moreover, Curcumin is a medical herb of a powerful antioxidant, anti-inflammatory , antimutagenic, antimicrobial , and anticancer properties .