In this paper, we add to the body of evidence in the literature that polyphenols are a frequent-binding class of chemicals produced by plants. We show that the pharmacology of polyphenols may allow for viral infection-fighting potential due to the human body's inflammatory response and provide conjecture as to the evolutionary basis for a putative inflammation-induced antiviral function. Future work could include quantifying the effect of in vitro antiviral studies under inflammation with neutrophils present for such viral targets as SARS-CoV-2, CHIKV, DENV, and IAV/IBV.