• A crucial finding is that MOFs commonly employed in drug delivery applications may be substituted with potentially safer metallic centers such as Ag, Ca, and Zr. It is important to note that material selection for drug delivery involves various factors, including porosity, stability, and solubilitybriefly discussed in the present contextwhich these MOFs with alternative metallic centers may not fully address. However, techniques such as external surface functionalization could offer effective solutions to mitigate these concerns.