Here, we present a computaVonal, high-throughput workflow for idenVfying potenVal new PL soluVons featuring two predicVon algorithms to assess solubility and size-exclusivity of candidate pore carrier/solvent combinaVons. By combining solubility predicVon sobware and a size-exclusivity predicVon algorithm, and subsequently experimentally validaVng the predicVons (Figure ), we demonstrate the uVlity of these algorithms to design novel porous liquid soluVons. While we employ a down-selecVon strategy for the purposes of experimental feasibility in this workflow demonstraVon, we emphasise the uVlity and efficiency of the predicVve algorithms independently.