Tandem 3-step sequence to Pyronaridine. Beginning with nitrophenol 10 and having heteroaromatic 4 in hand (vide supra), both pyrrolomethylene groups were installed to yield intermediate 11. Stripping with methanol removed excess pyrrolidine, to which was then added an aqueous 2 wt % solution of TPGS-750-M. Introduction of HCl and Pd/C under an atmosphere of H2 led to nitro group reduction to give intermediate 12. The Pd/C was then removed via filtration of the reaction mixture through a short plug of Celite. To this filtrate was then added heteroaryl chloride 4 and the mixture was allowed to react at 75 °C for 16 h. Upon completion, the solution was basified to pH 8 with aqueous NH4OH and the precipitated Pyronaridine ( ) was collected via filtration, washed with water, and isolated in an overall yield of 95% over 3-steps. Since pyronaridine is offered as its tetraphosphate salt, opportunities for further purification exist, although were not pursued in these studies.