Additionally, we generated a network of the GO biological processes related to the aforementioned immune system PPi network using the EnrichmentMap Pipeline Collection software . The GO biological processes with the highest degree centrality were immune system process, immune response, leukocyte activation, cell death, cytokine production, apoptotic process, lymphocyte activation, cellular response to cytokine stimulus, adaptive immune response, T cell activation, inflammatory response, innate immune response, immunoglobulin production, positive regulation of B cell mediated immunity, IL-1-mediated signaling pathway, TNF production, IFN-I production, antigen receptor-mediated signaling, neutrophil activation, granulocyte activation, macrophage differentiation, hypoxia, dendritic cell differentiation, protein ubiquitination, blood coagulation, and reactive oxygen species (Figure and Supplementary Table ). Interestingly, all biological processes obtained are closely related to clinical and pathophysiological manifestations of COVID-19 .