Within each of these subsets, fragments were deduplicated and similarities for all pairwise fragment combinations were calculated and pooled by kinase groups. This results in fragment similarities per kinase group, while in each kinase group only fragments were compared that occupy the same subpocket. If fragments were indeed selective for specific kinase groups, a higher fragment similarity would be observed within kinase groups compared to across all kinase groups (i.e. pooling all similarities from all subpockets). Nevertheless, no significant difference can be observed (Figure .C). This result indicates that the collected fragments are potentially useful for the design of an inhibitor of any target kinase.