We used our MC/MD method to analyze the equilibrium water density in the moderately polar, buried, cavity of the T4 Lysozyme L99A/M102Q double mutant. We used the structures of 2RBO and performed two MD simulations where the Cα atoms were restrained. One simulation used only MD and the second used MC/MD; both included 200 ns of MD. In the MC/MD simulation, an MC step with NMC = 10 6 was performed after every 10 3 MD steps. We then used the GIST software within cpptraj to compare the water densities in the buried cavities between the two simulations.