Next, we performed the brute-force docking of the complete prepared 3.8 billion structures to the SurA and GAK targets using Schrödinger Glide in HTVS mode to generate the docking baseline for later comparison. With an approximate processing capacity of 40 compounds per minute per CPU core, Glide HTVS proved to be the fastest available method to generate a gigascale docking dataset. Glide HTVS gains its speed advantage from significantly cutting down conformational sampling compared to, for instance, the Glide Standard Precision (SP) protocol.