After confirming successful PEG-NHC installation on the AuNP surface and requisite stability assessment, the utility of AuNP-4 as a conjugatable platform was tested. In order to facilitate rapid and selective conjugation and prove the addressability of the available terminal azide group of AuNP-4, two routine click chemistry approaches were employed, namely (1) copper-catalyzed azide-alkyne cycloaddition (CuAAC) and (2) strain-promoted azide-alkyne cycloaddition (SPAAC) reaction. CuAAC experiments were conducted under aerobic conditions in a mix of H2O/MeOH, using 5 mol% Cu loading, with tris(3hydroxypropyltriazolylmethyl)amine (THPTA) as robust and water soluble Cu(I) ligand and phenylacetylene as alkyne. Upon mixing all components followed by the reductive-activation of Cu(II) with L-ascorbic acid , the reaction progress was monitored by 1 H-NMR via the appearance of the triazole C 7 -H proton as well as a low field shifted signal for the C 1 H2 protons at 8.00 and 4.50 ppm (Figure ). Despite the poor solubility of phenylacetylene in given reaction conditions, 1 H-NMR kinetics suggest rapid conversion underlining the facile addressability of accessible -terminal N3 groups incorporated in the polymer shell of AuNP-4, yielding clicked AuNP-5.