Next, two TKL kinases (RIPK1 and LIMK2) were compared with two TYR kinases (CSK and TXK) selected due to RIPK1's proximity to the TYR kinases on the UMAP, unlike LIMK2. This offered a test as to whether kinases are grouped more by structural or by sequence similarities. The structures of RIPK1, CSK, and TXK demonstrated substantial structural alignment, setting LIMK2 apart due to a disordered region extending from an α-helix. Interestingly, the two TYR kinases shared 65% sequence similarity, while the other kinase pairs exhibited only about 50% (Figure ), suggesting that the UMAP proximity reflects structural features more than sequence similarity. However, in contrast with UMAP of AlphaFold2 embeddings, the ESM2 embeddings emphasized family-based groupings, suggesting that they may prioritize sequence similarity or familial affiliations over structural nuances. These observations indicate that the AlphaFold2 embedding space is modulated by structural similarities, whereas the ESM2 embedding space is influenced by sequence similarity and familial relationships.