hibitor amongst the tested amide-linked 2-aminobenzothiazoles, but was inactive against T. brucei. For two of these compounds, V and III (for 2D structures see Tab. 1), crystal structures of the TbPTR1 complexes were determined and confirmed the positioning of the 3,4-dichlorophenyl moiety in the partly solvent-exposed subpocket D of TbPTR1 (Fig. ).