Chiral Lewis acid catalyzed Diels-Alder cycloaddition is known as one of the most important, efficient and useful click reac-tions in medicinal chemistry and material design, considered a powerful method to access optically active compounds. This reaction between a diene and a dienophile generates two σ bonds stereoselectively and up to four chiral centers in a single step resulting in a six-membered cyclic compounds. This cycloaddition reaction named after Professor Otto Paul Hermann Diels (1876-1954) and his student Kurt Alder (1902-1958) was discovered in 1928 during the studies on the reaction of benzoquinone with cyclopentadiene .