Treatment of silanol aziridine A with catalytic Sc(OTf)3 and NaHCO3 in CH2Cl2 formed amino tetrahydrofuran B as the sole product (Scheme 2A). This result was exciting and a bit unexpected for several reasons. First, there was no trace of the silanol auxiliary. Furthermore, the reaction was perfectly stereospecific and the product was a 1'-amino-tetrahydrofuran, a family of molecules found extensively in medicinal chemistry patents. A search of the literature revealed that, by far, the most common method for the synthesis of 1'-amino-tetrahydrofurans is via radical additions into imines (Scheme 2B). Other approaches include hydrogenation of furans and cyclization of linear diols (Scheme 2B). While these methods are inspiring, they suffer from lengthy starting material preparations or from a lack of stereoselectivity during product formation. To our surprise, the ring opening of aziridines by pendant free or protected alcohols has only been sparingly explored for the synthesis of 1'-amino-tetrahydrofurans. Das and co-workers have studied the cleavage of aziridines bearing pendant phenols ; during preparation of this manuscript, Phipps and coworkers disclosed some 5-exo cyclizations of aziridine alcohols as part of a larger study on enantioselective aziridination. Together, these two reports represent the closest precedent for our own efforts, and only the Das study was present when we began our own investigation.