Thus, we screened twenty-nine canonical co-regulator interaction motifs for recruitment to TLX in apo-state or in presence of varying concentrations of caffeine (8, Figure ). High HTRF indicated potential binding of nuclear receptor co-repressor 1 (NCoR1) and silencing mediator for retinoid or thyroid-hormone receptors (SMRT, also termed NCoR2) to the TLX LBD. Titration of NCoR1