have shown the highest loading capacity of 50 and 42 wt.%, respectively (Table ). The six drugs i.e. dasatinib, sunitinib, vorinostat, cabazitaxel, genistein and sorafenib with three proton donor groups (Table ) have shown a varied loading capacity of 22, 5, 16, 50, 30 and 36 wt.%, respectively (Table ). Additionally, water molecules also have strong influence on the conformation and aggregation morphology of many drug delivery vehicle . The simple mathematical calculations like solubility parameters determination for such kind of complex system is obviously insufficient to get realistic compatibility profile. So the discrepancy between experiment formulation results and the compatibility estimation by aforementioned group contribution methods are likely due, in part, to the absence of such factors in general calculation.