Alzheimer's Disease (AD) is a complex and multifactorial neurodegenerative disease influenced by genetics, lifestyle, and environmental factors. AD is the most common form of dementia, and its prevalence is expected to increase from 50 million people in 2010 to 113 million by 2050 worldwide . AD is often divided into three stages: (1) preclinical stage characterized by normal cognitive ability, (2) prodromal stage characterized by mild cognitive impairment (MCI) and ( ) dementia stage . Current diagnosis relies on clinical symptoms and pathological alterations indicated by biomarkers such as reduced Amyloid-β1-42 (Aβ1-42) or increased p-Tau and t-Tau concentrations in cerebrospinal fluid (CSF). Neurofilament light (NfL), a neuronal cytoplasmatic protein highly expressed in large caliber myelinated axons, has also recently emerged as a nonspecific biomarker of neurodegeneration. CSF and blood NfL levels are elevated in multiple neurodegenerative diseases, including AD, in response to axonal damage . AD pathology starts decades before the clinical symptoms appear. Moreover Aβ and Tau protein are quite stable in clinical AD, and may not always differentiate AD from other types of dementia, leading to a high rate of misdiagnosis in the early stages .