Kinases from the TKL group are mainly clustered together with kinases from the Other group but some are separated from the rest (DLK, BRAK, IRAK2, and LIMK1). Kinases from the CK1 group build one group except for TTBK1 and TTBK2. Kinases from the AGC group cluster together as well; MSK1 is the only outlier that is found closer to the CAMK kinases. Lastly, only three atypical kinases are included in the KiSSim dataset (ADCK3, RIOK1, and RIOK2) and build their own cluster, neighboring to the CK1 kinases.