The reported Al-PMOF synthesis is in pure water at a relatively high temperature (180 ºC). We have carried out some attempts to synthesize Al-PMOF at a lower temperature or in pure dimethylformamide (DMF), which easily dissolves the ligand, but at these conditions we do not produce the MOF. If we repeat the synthesis in pure water, we obtained variable yields (40% to 90%) (Table ). It is therefore interesting to systematically explore the synthesis conditions. For this purpose, we used our high-throughput microwave-based robotic platform (Figure ). We start our first set of experiments (first generation) which aims at giving the most diverse set in terms of experimental synthesis conditions. We explored the following set of five variables: