Because some xenobiotics can be stored within organisms at higher concentrations than measured in the environment, increasing their concentration across the trophic chain and achieving harmful levels in fish, wildlife, and humans, the bioconcentration factor (BCF) is essential in aquatic environmental assessments . Accumulation can take place at each trophic level, either through the skin or respiratory surfaces (such as lungs or gills), . which is referred to as bioconcentration, or through the food that an organism consumes, which is referred to as dietary bioaccumulation . This results in a rise in chemical concentration with increasing trophic level, which exposes organisms at high trophic levels, such as humans, to long-term repercussions that are difficult to predict, such as endocrine disruption . Large regulatory efforts are being made to find and get rid of the compounds that bioaccumulate the most. This is because pollution is now seen as a threat to both the environment and human health, which has made people more worried. BCF data are in high demand because they are required by the European Commission's (EC) regulation Registration, Evaluation, Authorization, and Restriction of Chemicals (REACH) , and they may also be useful in the context of the Globally Harmonized System (GHS). REACH is an initiative that aims to enhance the protection of human and environmental health while simultaneously facilitating the free circulation of chemicals via the early identification of chemical properties. The Globally Harmonized System (GHS) standard is designed to offer a globally consistent framework for the categorization and labelling of chemicals. The rule known as the Classification, Labeling, and Packaging (CLP) regulation is responsible for putting the Globally Harmonized System into effect in Europe. This regulation is a part of REACH. The current European Regulation on the REACH makes it essential, among other things, to estimate the rate of bioaccumulation for chemicals that are manufactured or imported in quantities that are greater than 10 tonnes per year. This regulation was passed in 2007. Expensive and time-consuming bio-concentration measurements are only needed for substances that are made or brought into the country in quantities of more than 100 tonnes per year. BCF is the requested criterion for bioaccumulation assessment in many regulatory frameworks , but its determination is very expensive (more than 35,000 euros) and requires the use of more than 100 animals for each standard study, which has led to a general lack of data in the field. Because of this, the development of models to anticipate BCF has been necessitated. In the context of regulation, the primary goals are to choose and use parameters that are fundamental and simple to compute (like log P), and to develop models that can assist in the prediction of the BCF data that is the most accurate possible . In Annex XI of the REACH Act, the prerequisites for the appropriate selection and application of quantitative structure-activity relationship (QSAR) models for regulatory purposes are stated . This sets the framework for the application of QSAR models that are faster and more cost-effective in order to evaluate the bioaccumulation potential of chemicals, as well as the creation of predictive models. Over the course of several decades, a great number of conceptual models for predicting BCF have been created . However, in more recent years, there have been publications of a few categorization models. Regression models make up the vast bulk of these models. A normal distribution of the data set is supposed to be the case for regression models, and the vast majority of BCF data sets have a normal distribution. This might be one possible cause.