Overall, this does highlight the potential for missing serendipitous discoveries when automating the data analysis and categorising the reaction outcomes, as the automated workflow identifies the relative reaction outcome of each experimental characterisation technique. However, we believe it does not outweigh the benefits gained from rapid data collation and interpretation as it still accelerates the identification of cages with known topologies, paving the way for a data-led approach in POC discovery. In addition, the automated data analysis could be expanded to include the identification of potential intermediates for each cage topology, and competing chemistries, to get a broader understanding of the reaction pathway and outcome.