Fine-tuning data were collected from ChEMBL v33 . All annotations for MAPK1 were retained (target ID: CHEMBL4040). Available assay descriptions were manually inspected and analyzed. Molecules whose inhibitory constant (K i ) was lower than 1 µM on reliable inhibition assays (CHEMBL3412886, CHEMBL917079) were retained. SMILES canonicalization and removal of stereochemistry and duplicates led to a set of 68 unique SMILES strings for finetuning (SMILES available in the dedicated GitHub repository).