The spatio-temporal controlled release of therapeutic molecules can offer a significant improvement in the management of various diseases. In particular, in the case of hybrid hydrogels the formulation can be carefully harnessed to prolong the retention time at the injection site and maintain useful drug/nano-object concentrations at the site of action for extended periods. The result is higher efficacy, reduced side effects and an overall improvement of the therapeutic index. By prolonging the duration of action, these formulations might also reduce the need for frequent administration, which can significantly improve patient compliance and adherence to treatment and would translate into a better therapeutic outcome. To achieve these objectives the rheological and mechanical features of hybrid hydrogels are key parameters.