We next analyzed the rediscovery rates of generated compounds using RL alone, the results of which are shown in Fig. . For public projects, other than GSK3, we could find compounds identical to real high activity compounds. The percentage of rediscovery for DRD2, CDK2, EGFR, and ADRB2 were 0.30%, 0.13%, 0.52%, and 0.09% for all 5,000 generated compounds, respectively; when using the in silico classification score for ranking 1.0%, 0.8%, 1.0%, and 0.4% of the 500 highest-scored generated compounds represented known actives, while this was the case for 2%, 3%, 2%, and 1% for the top 100 scored generated compounds, respectively.