The local CO2RR environment has been extensively modelled and conclusions applied to improve the selectivity of heterogeneous, and heterogenised molecular catalysts. Due to competition between HER and CO2RR when using synthetic catalysts, compromises, such as basicity, are often made to minimise the HER even at the cost of CO2RR activity due to the overall benefit of selectivity. The complexity of these interfacial interactions is considerably reduced when considering enzymatic catalysis due to the inherent specificity, selectivity and low overpotential requirements of the protein to drive catalysis. Without the competing HER, the local environment in enzymatic systems can be controlled without compromise to facilitate the CO2RR. Therefore, enzymatic CO2 electroreduction provides a paragon for the development of more 'ideal' synthetic molecular catalysts in the future.