The degradation of ciprofloxacin (CIP), a widely used antibiotic, under UV-A light was carried out to investigate the efficacy of synthesized tri-doped photocatalysts and TiO₂. Photocatalysis is a promising method for addressing the persistent presence of antibiotics in wastewater, as it can break down complex organic molecules into simpler, non-toxic compounds. This study evaluates the degradation efficiency of three tri-doped photocatalysts (B1Ce1Ag0.1TiO₂, B1Ce1Ag0.06TiO₂, and B1Ce0.1Ag0.06TiO₂) in comparison with pure TiO₂.