Step, 1-pot conversion of 4 to Pyronaridine. The SNAr followed by the Mannich-like reactions could be performed in water in a 1-pot fashion. An initial SNAr reaction between 4 and 5 was performed to afford adduct 6 (Scheme 5). The reaction mixture was then neutralized with NaHCO3, after which was added 7, 8, and Et3N. Pyronaridine 9 was thereby obtained in quantitative yield over both steps.