To address the regioselectivity issue, the most commonly used and fruitful strategy is to run the process intramolecularly by introducing a pendent nucleophile to the substrates. 8 Also effective is the employment of tri-substituted alkenes as substrates, which usually leads to clean tertiary functionalized products as guided by the Markovnikov rule. 9 A recent study from Zhao suggests that the hydroxyl group resided at the allylic position can function as a directing group (via precoordination with the selenium cation) to enable a selective anti-Markovnikov aza-Wacker imidation reaction (Scheme 1c). A more general solution is by electronic perturbation via the installation of an electron-withdrawing group (EWG) at the allylic position, as firstly reported by Tunge (Scheme 1d). Thus, by virtue of the reversibility of the chloroselenylation and oxidation processes (A→C, Scheme 1a), 12 a rate-limiting dehydrodeselenenylative elimination eventually leads to an allylic chlor-SCHEME 1. Selenium-p-acid catalysis and our work. ide product. The acidity of the proton α to the EWG accounts for the profound regioselectivity by facilitating the irreversible deprotonation process. Linear alkenes bearing no allylic EWGs result in complex product mixtures. Similar strategy was later found to be applicable to the elegant selenium-p-acid catalytic amination, 13 oxygenation 9b,14 and fluorination 9c,15 reactions.