With the growing interest in applying DEDs to diffraction measurements, the use of fast EBEC strategies offers advantages for MicroED data collection. We find that these tools enable the determination of accurate atomic structures of organic small molecules with electron fluences as low as 0.5 e -/Å 2 . Although CL is expected in EBEC data, the count rates observed under low flux conditions suggest only a small fraction of diffracted intensities suffer significant losses. Further, a CL adjustment to measured electron counts can take into account anticipated losses of electron counts and enhance dynamic range. Importantly, fast EBEC expedites the determination of accurate structures from beamsensitive biomolecules such as biotin, without imposing added labor or time to data collection. This is further facilitated by the compatibility of new DEDs, such as the Apollo, with semi-automated data collection tools, such as SerialEM. Finally, by reducing the need for sampling and combining data from large numbers of crystals, fast EBEC further expands access to structures from rare beam-sensitive crystals, polymorphs, or trace impurities.