Although not universal, it is generally assumed that an electrocatalyst is needed to reduce oxygen. Recently, organic mixed ionic-electronic conducting polymers (OMIECs) have been reported to exhibit catalytic behavior for electrochemical reactions. OMIECs are semiconducting conjugated polymers with synthetically tunable structures and transport properties enabled by electrochemical ion-insertion redox reactions. These electrochemical doping reactions drive the insertion of mobile ions and electrons (or holes), providing functionality for a range of electrochemical devices. For electrocatalysis, hole/anion transporting OMIECs (p-type), including PEDOT (poly(3,4-ethylenedioxythiophene)) variations, have been studied for oxygen reduction and display selectivity for the 2-electron reaction. BBL (poly(benzimidazobenzophenanthroline)), an electron/cation transporting (n-type) OMIEC, has also been shown to be active for the ORR, with pH-dependent selectivity for the 4-electron versus the 2-electron product. These studies highlight the potential of OMIECs as electrodes for oxygen reduction, but the fundamental design principles that control their activities and selectivity are still being developed.