In this work, we investigated the shifts in charge density due to (long-range) vdW interactions in chemical and biological systems, using the MBD model with an appropriate parametrization and dipole-coupling tensor. We demonstrated that while such polarization can be safely ignored in small molecules like benzene, it becomes significant in larger, extended systems from S12L and L7+ datasets, sometimes surpassing the magnitude of ∆ρ(r) from semi-local DFAs like for CBH alkane chain.