In view of the advantages offered by the liquid, modular form of the active ingredient, including the ability to avoid the problems associated with the use of a solid form of the active ingredient (e.g., low bioavailability and polymorphism) and increased activity against the target organism through structural modifications or the use of an appropriate combination of ions, the use of ILs (and, more recently, DESs ) is a legitimate strategy for designing new biologically active substances . In agrochemical treatments, the use of more than one herbicide is popular, since such a measure broadens the spectrum of action of the herbicide formulation and can also counteract the acquisition of resistance by undesirable vegetation . The transformation of the herbicide active ingredient into an IL may also result in a significant increase in the biological activity of the new substance against weeds compared with that of reference formulations . Moreover, the observed increase in efficacy is due mainly to the favorable surface properties of the IL solution applied, which improves the penetration and action of the herbicide anion . Thus, it becomes reasonable to use a DSIL strategy and combine a surfaceactive cation with two or more active anions originating from known herbicides (e.g., 4-chloro-2-methylphenoxyacetic acid (MCPA) and 3,6-dichloro-2-methoxybenzoic acid (dicamba), Fig. ).