Figure shows the reaction progress versus time for the reaction conditions listed in the equation. Notably, the majority of the conversion took place in the first 12-24 hours, at which point the reaction rate decreased. The loss of mass balance over time is minimal and consistent throughout the reaction, suggesting no major byproduct formation. Rather, the behavior is characteristic of catalyst deactivation, as described above from mechanistic studies of the achiral reaction. We additionally monitored er over time, and found that it was consistent at 24 h, 72 h, and 7 days (see SI). Thus, the enantioselectivity is similar over the course of the reaction. In the remainder of the studies, mass balance remains satisfactory, so we focus our attention on product formation and er only.