To analyze the effect that fingerprints have on capturing the distribution of NPs in the chemical space, we compared their bidimensional embeddings via UMAP (Figure ). Additionally, we investigated whether any embedding could separate NPs according to different taxonomical classes, given that different organisms produce biomolecules in different ranges of molecular weight, fraction of sp3hybridized carbon and logP. To do so, we colored the UMAP projections of NPs according to their taxonomy, after removing all compounds originating from multiple organisms.