The present study explored the sensing abilities of an integrated optics construct, referred to as an Optical Chemical Bench (OCB). Au-Ag bimetallic nanoparticles with imperfect core-shell structure (AuAg NPs) were employed as the SERS agents. The AuAg NPs were bound to the surface of a multimode slab waveguide by adsorption onto the glass waveguide surface based on the principle of a metal-clad resonance structure. 3-Aminopropyltrimethoxysilane (APTES) was used as a molecular adhesive. Sparse coverage allows the TE and TM modes to propagate over sufficient distances so that polarized SERS can be collected from the waveguide streak when imaged into a polychromator. Rather than selecting a uniform metal film, this plasmonic nanoparticle configuration was chosen to provide sufficient path length for molecular detection through the SER effect. The starting point for the OCB is shown in Figure on the left. To test the abilities of the OCB to sense molecular orientations, ion binding, and nanoparticle binding, hierarchies of assemblies were constructed from the bimetallic particles on the OCB. The adsorbed analytes include 4-aminobenzoic acid (bottom), 4-mercaptopyridine (middle), and 4aminobenzoic acid-functionalized magnetite nanoparticles to the AuAg nanoparticles (top). The 4-mercaptopyridine construct can be used to bind Fe 2+ . The nanoplasmonic AuAg cladding and its components were excited with TE or TM polarized light that was injected into the waveguide by prism coupling. Finite-difference time-domain (FDTD) calculations were carried out to give additional insight into the excitation and interaction of plasmonic nanoparticles near the waveguide surface.