Fig. Unbinding rates or k off (s -1 ) for 17 Hsp90-inhibitor complexes obtained from experiments and QMrebind-reparameterized force field parameters employed in SEEKR2 simulations. The experimental k off rates were obtained using Surface Plasmon Resonance (SPR) measurements (refer to Supplementary Table for a list of references for experimentally measured k off for each of the Hsp90-inhibitor complexes). The horizontal axis is represented in a logarithmic scale, allowing for better visualization of k off rates that span several orders of magnitude.