In order to determine whether the extracellular ORF7a binds to the CD14 molecule, we made the extracellular ORF7a to the human CD14 molecule for protein docking. The PDB database only has human CD14 molecules (PDB ID: 4glp) and Mus musculus CD14 molecules (PDB ID: 1WWL). The human CD14 molecule (4glp) is a monomer, and the Mus musculus CD14 molecule (1WWL) is a dimer. The C-terminal sequence of the CD14 molecule is mainly involved in GPI anchoring . C-terminal truncation does not affect the relative biological activity of LPS binding . The relevant biologically active site of LPS is within the N-terminal half of the CD14 protein 126 . Our protein docking results show that the end of the N-terminal of extracellular ORF7a can bind to the 1WWL dimer, but the extracellular ORF7a cannot bind to 4glp.