Recently, some porous materials such as covalent organic frameworks or polyanion-metal ion systems were proposed for lipid removal. However, conventional SPE materials remain as the most common method for the depletion of lipids and enrichment of certain compounds in metabolomics studies, with varying degrees of extraction efficiency . While SPE selectivity is very advantageous for targeted experiments, it presents a challenge for untargeted global profiling as can lead to the depletion of analytes of interest and introduce contaminants . SPE is typically performed by loading samples onto a packed bed of sorbent material and eluting unbound metabolites for downstream analysis. So-called "dispersive SPE" (dSPE), based on the addition of a sorbent directly into the analytical sample extraction solution , allows for easier handling and rapid sample processing.