The estimate of 6.5 PLP score change, which is approximately correct in numerous examples and ranges from IC50 data , to 1 kcal is used to translate. The interaction energy is approximately .4 kcal different between the 2 strains of AHAS and CS. This is 10 .4 =2.5 in bound affinity as affinity scales exponentially in base 10 with 6.5. The minimum dose was given to the Soybean strains to eliminate the susceptible one. A bound affinity of x2.5 would presumably require at least 2.5 more to have the same effect. In other words, out of the 500 docking runs, 50% were in the low scoring binding mode and 50% in the high one; to achieve the same number from a 77%, 23% mix in the resistant case would require a dose x2.2, close to the quantifiable x2.5. However, these calculations do not consider the conformational shape and location in or about the cavity containing 197.