For demonstration purposes, in Figure and 3b, we plotted the nucleation rate obtained using the classical nucleation theory as a function of temperature based on the G values calculated using the model proposed as in equation ( ) for all the 17 different combinations of APIs/solvents involving 12 APIs. It is worth mentioning here that the molecular weight of the different APIs ranges from 73.09 to 421.3 g/mol. For these APIs, according to the model proposed in this work and the nucleation temperature studied, the nucleation rate ranges from 10 22 to 10 24 kJ/mol. In Table , we showed the theoretically obtained tind and Tmax for all the 17 different combinations of API/solvent systems. The Nm/V typically range from 10 22 to 10 25 molecules/m 3 when time, t = tind. To conclude the proposed model is set ready to calculate the parameters from the MSZW at different cooling rates that includes the nucleation rate kinetic constant, Gibbs free energy of nucleation, induction time and the number density when t = tind. The model needs information about the MSZW, nucleation temperature, and the cooling rate. We showed that the model is universal as it well represents the experimental data of MSZW of different API solutions at different cooling rates. The model directly relies on classical nucleation theory, and this allow to mathematically predict the useful thermodynamic parameters such as the surface free energy, radius of the critical nucleus and the number of unit cells that constitute the stable nucleus. The model can be used to obtain the nucleation parameters of the other systems, provided we have measured the MSZW of the solutions at a fixed cooling rate but for different solubility temperatures (𝑇 * ).