The recent paper by in Journal of Nanobiotechnology is on the synthesis of Ti2NTx MXene. MXenes are novel two-dimensional (2D) materials, which are prepared by selectively etching away A-site element from MAX (Mn+1AXn) phase with hydrofluoric acid (HF) or fluoride salts solutions , where M is an early transition metal, A usually belongs to groups A and VA, X is carbon and/or nitrogen. In general, MXenes are made from carbide MAX phases (e.g. Ti3AlC2) or carbonitride MAX phases (e.g. Ti3AlCN) . It is very difficult to make MXene from nitride MAX. Ti2AlN is the most common nitride MAX phase. If Ti2AlN can be selectively etching, Ti2NTx MXene can be made and it is predicted to have excellent properties. However, there is only one report on the experimental synthesis of Ti2NTx MXene by Soundiraraju et al. at 2017 . In that report , it was claimed that Ti2NTx MXene was successfully made from Ti2AlN by KF/HCl etching. However, as the authors know, there are no reports to repeat that work.