The Montreal Protocol and the Stockholm Convention have demonstrated that grouping substances can be an effective strategy to expedite the elimination of the production, use, and emission of toxic substances such as ozone-depleting substances (ODSs) and persistent organic pollutants (POPs). This approach can also accelerate the identification and regulatory processes for substances that lack hazard information. Grouping can prevent the introduction of new hazardous substances into the global market. However, it is important to ensure that grouping is done in a way that is feasible and promotes the use of safer and more sustainable alternatives.