These results demonstrate that the introduced disulfide motif is well-tolerated, and that the previously observed trend of diminished degrader potency with shortened linker length is maintained with these disulfide-containing Homo-PROTACs. Crucially, the degradation potency of the new compounds correlated well with their ability to induce VHL dimerization, thus supporting our working hypothesis for the ternary complexdirected DCC assay. ) with in vitro formed fraction of ternary complex from native gel electrophoresis assay (presented in Figure ). Values of two biological replicates of each experimental set were averaged for plotting.