In addition, Aligator and BracketMaker are designed to bring CPS to a wider user base. As CPS finds increasingly varied applications in bioscience and drug discovery, 2,4,5 it is on the cusp of becoming a commonplace technique. The modern chemical methodology of CPS is well established, robust, and based on commercially available reagents, making the technology theoretically accessible to any lab with SPPS capability, but the complexity of information is a major barrier to entry. With the tools described here, however, anyone can begin with a target protein sequence and obtain a step-by-step synthesis plan in a matter of minutes. Both Aligator and BracketMaker are open-source and freely available to download, and we look forward to feedback from the community as these programs see more widespread use. Ultimately, we aim to increase accessibility of protein synthesis, facilitate communication across the CPS field, and equip researchers with the information needed to take on increasingly ambitious proteins.