Several published studies focus on the use of chemical space as a tool for assessing the diversity of data sets and exploring the relationships between compound collections. For instance, the chemical space of nearly 43,000 naturally occurring compounds from Latin America and other geographical regions has been analyzed. It was concluded that the natural products data sets occupy similar regions in the chemical space and are an attractive source for obtaining novel leaders able to become new pharmaceuticals . These observations are consistent with previous studies that showed that natural products cover a broader region of the chemical space as compared to approved drugs and synthetic compounds, and they populate areas of the chemical space that are difficult to synthesize .