Since this is exclusively a computational tutorial, we will use the molecular docking software AutoDock Vina in place of these experimental studies. UCSF Chimera enables AutoDock Vina to be used as a plugin, which allows us to conveniently perform molecular docking and view the docking results in UCSF Chimera. We will first evaluate the ability of the cyclic peptide inhibitor to bind the SARS-CoV M pro in silico and thus test our cyclic peptide inhibitor design. We will then evaluate the ability of the cyclic peptide inhibitor to bind SARS-CoV-2 M pro in silico to test our inhibitor against the relevant target of COVID-19.