Once we built a function capable of replicating most published brackets, we wanted to expand this program into an interactive bracket-building tool. When planning a new CPS project, one must carefully consider ligation sites to divide a protein into SPPS-compatible segments, then choose an efficient ligation order to maximize final product yield. We thus sought to 5 develop a tool that could be used for this retrosynthetic analysis -beginning with a protein sequence, gradually making decisions about ligation strategy, and ending up with a detailed plan of all reaction steps and requisite aa modifications (and multiple backup plans, in case of unforeseen obstacles encountered during synthesis). Importantly, we wanted this tool to be easily accessible and not require programming ability. To this end, we developed BracketMaker, a free 10 standalone executable containing an interactive workspace for designing brackets, with custom functions to score brackets and rapidly draft multiple strategies.