Assessment of sequence coverage, pepNde idenNficaNon and CQA analysis was carried out according to parameters summarized in the peer-reviewed protocol published by Millán-Mar•n et al . For the monitoring of CQAs in this study, a target pepNde workbook was generated within BioPharma Finder, and components were filtered to consider pepNdes with up to one missed cleavage with the sole excepNon of TKPREEQFNSTYR, which was also included because of its significant abundance and its relevance for the evaluaNon of Fc N-glycans. PepNdes containing sodium or potassium adducts, as well as those that correspond to nonspecific protease acNvity, gas phase generated ions, or unspecified modificaNons, were excluded.