The new oxetane containing motifs were amenable to further derivatization (Scheme 2d). Oxetane azide 59 underwent copper-catalyzed azide-alkyne cycloaddition (CuAAC) to afford triazole 88, expanding the potential scope of oxetane 1,2,3-triazoles available. The bromide handle of N-oxetane-sulfoximine 73 was further functionalized through palladium-catalyzed Sonogashira and Buchwald-Hartwig cross-coupling transformations in good yields. OTIPS OSF 2 reacted efficiently with 2-methyl benzimidazole with concomitant TIPS deprotection to afford oxetane-benzimidazole 91 in high yield. The phenol handle was converted to the aryl chloride through triflation and palladium-catalyzed chlorination to generate an oxetane analogue of chlormidazole (92), a marketed antifungal treatment.