The Loewe-Additivity model is already well described so in Figure the idea was to use the same mathematical model but apply it to a combination of two drugs that shared a common pathway and then create a network of the drug-pathway combinations. This shows a much larger network that has 177 nodes and 1811 connections. This increased connectedness, compared to the standard approach, also gives an increase in the number of potential combinations to send to the scoring algorithm. This also greatly increased the number of combinations that are possibly synergistic to 1089.