It was hypothesised that the structural motifs of API dimers in solution encode the polymorphic outcomes of crystal nucleation. As such, MD simulations of organic molecules in solutions have focused on the association of monomer building blocks to support experimental studies. In simple 2D models of flexible chiral molecules, Carpenter and Grünwald recently demonstrated how bulk crystal structures are related to the organisation of building blocks prior to nucleation and the importance of kinetics in predicting polymorphism.