We previously found that these rearrangement reactions suffer from a competition between conversion to desired product and undesirable elimination side-products. While we were not able to improve the yield of the reaction beyond 30%, we used our best conditions from Table to probe the scope of the thermal phthalimide and BCP-I reaction. Twenty iodo-BCP amides 2a-t were converted to the corresponding BCB-phthalimides 3a-t (Scheme 3). After verifying the heat stable adamantyl amide 3a could be prepared, we prepared tert-butyl ester 3b and benzyl ester 3c, which were tolerated in the reaction. Heterocyclic amides such as pyrrolidinederived 3e, tetrahydroisoquinoline-derived 3f, and phenylpiperidine-derived 3g were all tolerated. Ketones 3j and 3r, which are susceptible to both enolization and nucleophilic attack, were isolated in 24% and 18% yield respectively. Single-crystal Xray diffraction analysis confirmed the structural assignment of the BCB skeleton with Boc-protected piperazine 3q (Scheme 4).