Next, we compared MAF and PF values obtained for 1 -5 and co-formulations a, d and j with physicochemical data (Table ), including zeta potential. As shown in Figure , although there was no trend identified between permeation factor and zeta potential value, there is a trend between MAF and zeta potential. Here, to achieve a MAF < 0.5 the zeta potential value must be between -70 mV and -80 mV. In our previous work we have provided evidence towards a relationship between the enhanced stability of a SSA aggregate formed under these experimental conditions and the presence of hydrogen bonded intermolecular interactions, in addition to increased antimicrobial properties. We believe that this trend provides evidence that these same factors that drive SSA aggregate formation (SSA anion intermolecular interactions and lipophilicity) also contribute to enhanced membrane adhesion properties.