Our analysis focused on the depolymerization of co-polymer PES2 for 6 days with 1 µM LCC WCCG or Tc_Cut2NV WCCG compared to the negative control. RPLC-UV and SEC-UV results from the hydrolysis of the polymer using LCC WCCG and Tc_Cut2NV WCCG can be found in SI Fig. and. RPLC-UV results revealed a slow hydrolytic behavior of PES2, similar to that of PES3. However, unlike for the homopolymer PES3 and PES4, SEC-UV analysis of the unsoluble polymer revealed that PES2_LCC sample (i.e., depolymerization of PES2 by LCC WCCG ) presented a significant reduction in molecular weight (Mn from 9748 to 6223 and Mw from 16809 to 11824). Limited MW reduction was observed for the PES2 sample treated with Tc_Cut2NV WCCG (Mn from 9748 to 9480 and Mw from 16809 to 16170).