In this work, we propose a new analytical framework that performs methane emission detection, localization, and quantification using raw concentration data from any network of point-in-space CMS sensors. The framework has two primary use cases: (1) alerting, in which localization and quantification estimates are provided to the operator in near real-time, and (2) inventory development, in which quantification estimates are used in aggregate to determine cumulative emissions at a given cadence. The proposed framework is best suited for production sites that are around 150m in diameter and contain spatially distinct equipment groups (e.g., wellheads, separators, and tanks).