DUD-E is an enhanced benchmark comprising 102 diverse targets and 22,886 clustered ligands from ChEMBL, each supplemented with 50 decoys from ZINC. As shown in Table , our GGAP-CPI-IntEns achieved an EF 1% of 41.642-slightly lower than BIND's 46.35 but outperforming most traditional and machine learning-based scoring functions such as Vina 10