This assumption holds only when the dataset size is sufficiently large and the quality of training and validation (or testing) datasets is comparable. For small-scale data, as in our case, the applicability of such a hypothesis is dubious. Another issue with Boruta is the interpretability of the proposed explanatory variables. Although the suggested parameters, such as EState_VSA7, SMR_VSA10, and VSA_EState6, might help predict the refractive index, they are highly specialized parameters that no one outside of cheminformatics experts may fully interpret.