compounds tested across all their annotated variants (Supplementary Figure ). However, the computation of fully dense common subsets proved to be relevant to achieve fair comparisons. In many cases, like for breakpoint cluster region protein BCR (P11274) and JAK2 kinase (O60674), the modelling protein set was highly biased towards WT bioactivity, making the fully dense common subset valuable for comparison (Supplementary Figure ). Given these results, a strategy was developed to compute non-fully dense common subsets -referred to as common subsets -for the previously mentioned two-thirds of proteins for which a fully dense common subset was not available. Common subsets generated for compounds tested in at least two variants with a variant coverage of at least 20% identified 115 targets for which a fully dense common subset was not possible. Overall, using these parameters to compute the common subsets resulted in very diverse subsets covering 229 targets with an average common subset of 35 ± 121 unique compounds and 5 ± 6 variants.