• Cancers such as breast, lung, rectal, prostate and liver appear to co-occur more frequently with certain genetic targets than others. • Overall, TP53 emerges as a highly explored target appearing to co-occur with each of the 7 cancer subtypes. • Out of the more than 25 targets co-occurring frequently, ~10 of them co-occur with more than one cancer type. • Besides TP53, other highly explored genes include c-Ki-Ras, c-myc, ERBB1 and BRCA1.