We hypothesize the successful transport proceeds in four critical steps: (1) a transporter molecule is activated in the sender phase, (2) it diffuses to the interface with chloroform and partitions into it, (3) it diffuses and is advected by the stirring in the chloroform phase to reach with a probability of 50% the receiver side and partition into it, (4) it is deactivated and can no longer escape. At each step, efficiency-decreasing processes occur. For example, in step 1, the activation of the transport molecule occurs via an intermediate called Oacylisourea, which can decay before converting to the activated transport molecule -the anhydride. In step 2, activated transport molecules likely deactivate before reaching the chloroform phase. In step 3, activated transport molecules can repartition into the sender phase, as well. In step 4, activated transport molecules can re-enter the chloroform phase before deactivating. Moreover, molecules can diffuse back through passive transport.