In this study we examined the performance of OPLS3e force field in membrane simulations. We demonstrate that OPLS3e produces C-H bond order parameters for POPC that are very close to experimental values and very similar when compared to the CHARMM36 forcefield. That said, in OPLS3e, as in many other force fields, the characterization of (especially of Ca 2+ ) ion binding to membrane seems problematic.