Open babel was used for chemical format conversion (openbabel.org). Swiss-ADME webserver was used for calculation of pharmacokinetic parameters and also for an independent estimate of LogBB permeability ) . UCSF Chimera was used for molecular graphics . Theseus 3.3.0 was used for structural superposition (dtheobald@brandeis.edu). ChatGPT 3.5 was used to collect some background information regarding epilepsy . DrugBank was used to identify approved drugs for epilepsy . The protein sequence for the target, human GABA-T, was downloaded from UniProt (The UniProt Consortium, 2023). The structure of rat GABA-T was downloaded from RCSB PDB . LibreOffice 6.4.7.2 was used for manuscript preparation (The Document Foundation, 2020). Zotero 6.0.26 was used for bibliography management (Corporation for Digital Scholarship, 2023). Autogrow4 and STgrow4 were implemented on a computer with Ubuntu 20.04 operating system .