Sulfur has been recognised as one of the earliest known elements for its therapeutic properties by the ancient Greeks. It is one of the essential components for all living organisms, occurring in the amino acids, methionine and cysteine, and in the vitamins, thiamine and biotin, amongst others. Approximately, 250 FDA drugs bearing sulfur-containing functional groups were approved, including for hypertension, diabetes mellitus, bacterial infections, migraine, cardiovascular diseases (CVD), neurological disorders, cancer, and human immunodeficiency virus (HIV) (Figure ).