In particular, our AIMD calculations and metadynamics sampling techniques indicate that all of the C-F bonds in PFASs have a likely probability to dissociate (even though specific C-F bonds might be more thermodynamically reactive). As such, some of the efforts by other researchers to target specific C-F bonds in PFAS could be counterproductive, since this process is inherently kinetically controlled. In other words, more research effort should be directed towards minimizing the diffusion distance of hydrated electrons rather than targeting the weakest C-F bonds since the degradation process is ultimately dominated by statistical/kinetic effects.