The structures of the different A 2A -StaR2-b RIL 562-ligand complexes were solved by molecular replacement (MR) with Phaser 71 (CCP4 suite) using the A 2A -StaR2-b RIL 562-theophylline complex structure as the search model (PDB code: 5MZJ). Iterative cycles of manual model building, and refinement were performed using COOT and Buster , respectively. 2 TLS groups corresponding to the receptor + ligand and to the bRIL 562 were defined during refinement. The final refinement statistics are presented in Table . Structure figures were generated using PyMOL .