Owing to the fact that RMD can be applied without prior knowledge of the system, it is particularly useful to find reaction networks for combustion of unconventional fuels such as biofuels and e-fuels. Studies of biodiesel and other oxygenated biofuels indicate the necessity of modeling a different low-temperature chemistry than what is established in analogies derived from fossil fuels . For those systems, RMD can simulate the formation and consumption of previously unknown intermediates, which may be difficult to observe in experiments.