To showcase the ability of Dedenser to leverage weighted cluster downsampling, positive and negative weighting of cluster densities were employed. When using a positive density weighting of 5, the cluster occupying the lower range of UMAP dimensions 0 and 2 is given greater membership (Figure ). Conversely, by using a weighting of -5, the alternative cluster has greater membership (Figure ). For the negative and positive weightings, molecules with lower and greater descriptor values are favored respectively and are distinct from random sampling (Figure ). In both cases, the downsampling done with Dedenser shows fewer clumping of molecules and more regular distribution in embedded chemical descriptor space when compared to random sampling (Figures ).