In this work, we have introduced the EVP methodology and have detailed its applications to three distinct drug discovery tasks. EVPs are a straightforward, objective diversity metric for quantifying the exploited vectors of a given molecular scaffold. This interpretability offers a valuable complementary means of characterizing the chemical diversity inherent within an ensemble of molecules, notably eliminating the requirement for scaffolds to be pre-defined and thus mitigating potential biases in SAR analyses. The usefulness of the method has been demonstrated through illustrative examples that highlight its broad applicability to different drug discovery problems.