The combined effects of multiple hydrogen bonds impart structural stability; the total dissociation energy of [(PO4)4124] 12-, assembled from 48 hydrogen bonds, was calculated to be 1709 kJ mol -1 . Acidic conditions, however, can protonate anions like PO4 3-, resulting in disassembly of the architecture. In summary, the key design principles of ACDAs are similar to those of coordination cages; ligands can be designed to be edge-or face-based, with the anion/ligand ratio controlled by the number of donor moieties, akin to the principal of maximal site occupancy, and the assembly stoichiometry controlled by the ligand geometry. The good solubility of ACDAs makes them suitable for study both in solution and the solid-state. Their anionic nature makes them particularly suited to the binding of cationic guests, while the ligand structure can be tailored to promote non-covalent interactions with encapsulated species. Whilst generally stable in the presence of bases, acidic conditions can lead to disassembly through protonation of the anionic nodes. As the first report of an ACDA capsule is little more than a decade old, it is perhaps unsurprising that applications for these systems have not been thoroughly explored. With rapidly growing developments in design principles, however, ACDAs have potential as highly useful supramolecular capsules. For a more detailed overview and analysis of ACDAs, including beyond capsule-type systems, the reader is directed to recent reviews in the area. 60