To improve the Martini 3 lipidome, we conceived a model that could be extensively verified by experimental data. Due to the "fuzzy" mapping of Martini 2 lipids , selecting experimental reference data was a major obstacle in benchmarking the model. For example, DPPC (1,2-dipalmitoyl-sn-glycero-3-phosphocholine) and DSPC (1,2-distearoyl-sn-glycero-3-phosphocholine) are mapped to the same Martini 2 molecule, although experimentally, DPPC and DSPC have significantly different bilayer thicknesses (DHH 3.46±0.07 nm versus 4.33±0.09 nm at 333 K). This ambiguity complicates fitting to atomistic simulations and validation against experimental data.