The dialdehydes 1-16 were only screened with the six triamines, with dialdehydes 2, 4 and 16 yielding the best reactivity where 4 (67%) reactions led to the clean formation of a single topology, but with no topology consistently observed in combination with triamines A and F. However, the successful reactivity of these dialdehydes with the other triamines can be expected as they have all previously been reported in the literature as organic cage precursors, albeit not in the same precursor combinations (Figure ). Clean formation of a single topology was also observed for dialdehydes 8, 11, 12 and 13 (50%), whereas dialdehyde 9 exhibited no reactivity across all reaction combinations. Finally, diamines 17-34 were each screened across 15 reactions, with 19, 20 and 33 showing no reactivity across any combinations, followed by 20, 21 and 34 where ~80% displayed no cage formation and the remaining ~20% yielded the formation of a single topology with either insoluble precipitate or incomplete conversion. Diamine 18 was the most successful diamine building block, with 14 (93%) of its reactions indicating formation of an organic cage across the three categorisations. Following this, 25 and 26 showed similar success with 13 (87%) of their combinations indicating evidence of cage formation via HRMS, arguably suggesting that 25 was the most successful diamine overall with 7 (47%) of its combinations resulting in the clean formation of a single cage topology.