Table is illustrated graphically in Figure -by way of one of the most studied flavonoids in the pharmacokinetic literature, quercetin. Inhibitory mechanisms of viral replication could be due to direct inhibition of viral proteins and enzymes, or by slowing ordinary cellular metabolic mechanisms such as respiration, translation, transcription as co-opted by the infecting virus. In one case, that of fisetin applied to Dengue fever, 104 fisetin showed no direct activity against DENV virions outside the cell yet effectively inhibited replication in-cell. The study's authors suggest it could be due to forming complexes with RNA or inhibition of RNA polymerases. While inhibition of the dengue RdRp would represent a virus-specific inhibition, it remains intriguing to consider that the replication inhibition could also be due to non-specific inhibition in a weakened cell.