To analyze the code performance, we used the Enamine REAL sulfonyl fluoride library (1.7 M compounds, updated in 2022) available from Enamine Inc. 11 as a representative library. Processing times reported have been measured on a low/mid-end workstation from 2017 equipped with 2x Intel Xeon E5-2640 v3, 32 GB DDR4-1866 MHz RAM, and a 4TB 5400rpm hard disk.