Glucose biosensor strips for point-of-care applications typically consist of screen-printed electrodes with a small volume capillary channel for sample loading. To integrate the enzymatic O2-scavenger into these sensor strips, the electrode layout and capillary channel were specifically engineered to create and maintain anaerobic conditions at the sensing electrode (Figure ). CAT and AOx were deposited on the inner surface of the capillary cover, while paraformaldehyde was distributed in solid form on a thin paper serving as spacer within the channel (Figure ). In comparison to the experiments in the large electrochemical cell (Figure ), the concentrations of the scavenger components were increased four-(AOx) to ten-fold (paraformaldehyde) to account for concentration heterogeneities within the capillary upon filling with the sample. GOx and the Os-complex modified polymer were drop-cast onto the working (sensing) electrode. When the aqueous sample fills the channel, the components of the O2 scavenging dissolve and spread throughout the channel, initiating O2 depletion (Figure ).