Alternative access towards 42q was also examined, where 47 was first converted to the Weinreb amide, followed by reduction and reductive amination. This less advantageous route was terminated at the stage of corresponding bromobenzylamine of type 41 (Scheme S1). To receive a vicinal hydroxy-fluoro disubstitution (Scheme 2), 3-bromo-2-fluorophenol (51) was reacted with 4-methylthiazole to 52. Subsequently, ortho-formylation of the phenol was performed using magnesium chloride, triethylamine, and paraformaldehyde, giving salicylaldehyde 53.