To address this concern, we proposed a novel linker generative model, named as PROTAC-INVENT, utilizing three dimensional PTS data as constraints. The workflow consists of two stages, i.e. generation of PROTAC linker structures (i.e. SMILES) from normal generative model and then creation of 3D binding conformation of PROTAC under the constraint of the binding pocket of a reference PTS. The model was finetuned via RL and generated PROTACs were scored based on their docking poses in the PTS binding site. Compared with other linker generative models, one unique feature of PRO-INVENT is that a practical workflow was developed to enable generation of 3D binding conformation of PROTAC in the binding site with relatively low computation cost, so that generation of PROTAC molecules is optimized by considering its fitness with the PTS binding site. Thus, this method is expected to be more effective in the generation of PROTAC molecules which need to satisfy the 3D requirement of PTS binding site.