Severe COVID-19 ill patients with acquired methemoglobinemia lead to refractory hypoxia and require red blood cell transfusion for treatment . The prevalence of beta thalassemia heterozygotes is related to immunity to COVID-19 . Patients with sickle cell disease and laboratory-confirmed COVID-19 usually have a mild or insignificant course. They face lower chances of intubation, ICU admission, and death, but a slightly longer hospital stay . In some epidemic areas, patients with severe COVID-19 patients have lower hemoglobin levels than those with mild illnesses, and lower hemoglobin levels can lead to anemia and complications .HP*2 alleles provide protection for certain people through its anti-inflammatory response from the severe impact of COVID-19 and other infectious diseases . The main function of haptoglobin is to combine with free hemoglobin to form a stable complex, and then it is processed by the mononuclear-macrophage system. There is a correlation between decreased serum hemoglobin and increased levels of ferritin and LDH . Since excessive hemoglobin phenotype,it is not entirely clear whether patients with thalassemia are particularly susceptible to SARS-COV-2, or whether they have a higher risk of complications from COVID-19 than the normal population .