Initially, four pools of PDB datasets were prepared; i) a list of empirically determined holo protein co-crystal structures with a covalent ligand bound at a ligandable sites ( "Holo sites"), ii) a list of experimentally solved apo counterpart structures of the holo protein list ("Apo sites"), iii) a list of cryptic proteins with a mock covalent site designated in their respective occluded binding cavity ("Cryptic sites") and, iv) a list of the most extreme surface residues lacking cavities or visible ligandable sites in their vicinities designates as "False-positive sites". The dataset used in ligandability detection power against holo sites comprised of 2,251 holo-protein structures from the covPDB database , apo sites comprising of 248 apo protein structures, cryptic sites comprising of 118 cryptic protein structures from the from RCSB database , and false-positive sites comprising of 112 false positive sites in the Cryptic-PDBs list (SupplementaryFile1).