The Moretti-Meiler team (WF1414) implemented the challenge on Drug-it within the Fold-it platform , where citizen scientists use an online gaming interface to grow fragments bound to Nsp13 available in the PDB. After multiple rounds of chemical modification, the closest commercial analogs were re-docked with RosettaLigand and ranked based on neural network-predicted absolute binding free energies . Interestingly, these widely divergent workflows ended-up producing the two best Nsp13 binders.