Possible functional extensions of Scaffold Generator include the incorporation of more abstract scaffold representations, based on the work by Xu and Johnson , and the possibility to build scaffold networks or trees encompassing multiple scaffold definitions of varying chemical resolution, like in Molecular Anatomy or the tree-like classification of Medina-Franco et al . A major addition to the functionality of Scaffold Generator would be the inclusion of analog series based scaffold methodologies. Since these have demonstrated significant relevance in the past years, this addition must be considered.