The identification of vibrational bands associated with the covalent bonds connecting the molecular fragments is often particularly valuable when the framework material is synthesized via a bimolecular reaction mechanism. Such an example could be the metal-phthalocyanine-based pyrazinelinked conjugated 2D COFs that are sythesized via a condensation reaction to form pyrazine linkages which are not present in any of the reactants. 114 However, COF-1 is synthesized via a unimolecular reaction, where the B-C bond is already present in the precursor molecule (1,4-benzene diboronic acid), making the monitoring of this bond in in situ Raman spectroscopy not beneficial. The purpose here is simply to demonstrate that such an analysis is possible.