The correlation and contact matrices were used as inputs to Bio3D 81 in order to perform Weighted Implementation of Suboptimal Paths (WISP) analysis. WISP is a technique that enables one to describe how distal regions of a protein allosterically communicate with one another, by describing a protein as a graph/network. In WISP, one defines a "source" residue and a "sink" residue which are distal from one another, and then determines the shortest pathways of communication between these two residues. This allows for the identification of the key residues and residue-residue interactions between the two selected residues that enable allosteric communication between them. A correlation cut-off of |0.25| was used to determine the 500 shortest paths between each source and sink. From these 500 paths, the node and edge degeneracies were determined alongside the path lengths.