Breakthrough ultrasearch technologies targeting extralarge combinatorial chemical spaces are available from several companies such as Enamine (), Enamine Real Space (), Freedom Space 3.0 (), and ChemSpace (). Alipheron Hyperspace, available through DW vs 6.2 (), offers > ~ 50000 millions of virtual molecules from cheap-fast combinatorial chemical synthesis. The presence of some molecules with terminal and internal alkynes (triple carbon bonds) may offer covalent binding possibilities 31, 32 . Alkynes internal of some specific organic molecules have been detected as physiological defenses in polyacethylenic fatty acids in beetles