The interface allows molecules similar to a given structure to be identified rapidly using Smallworld (Figure ). We call this process ABC -Analog By Catalog. The interface is like the one used in ZINC20, improved. Smallworld uses graph-edit-distance to perform the search and calculates two legacy fingerprints for comparison and resorting. Molecules found may be loaded into the shopping cart for retention and prioritization (see below). The advanced graph-editdistance options in the interface allow targeting of specific kinds of analogs, such as substructure, scaffold, and other types. For finding many compounds and their close analogs at once, a bulk search tool is available as a separate feature (see below).