These drawbacks emphasize the need for better or alternative treatments to overcome resistance or provide safer alternatives. The normal breast cell and HER2 overexpressed breast cancer cell is shown in Figure . In the next step, the nanovehicle enters the cancer cell cytoplasm and releases its contents, resulting in anticancer activity against the breast cancer cells. Docking is a computational technique that predicts interactions between ligands, such as medicines and biomolecules . This approach is critical in drug development and discovery efforts since it allows researchers to find the compounds that can most effectively inhibit/modulate cancer protein activity without actually building and testing the compounds in a lab setting. HER2 receptors are located on the surface of cancer cells, particularly those from breast cancer. Docking allows for the simulation of interactions between HER2 receptors and potentially effective compounds and the development of a method of blocking this receptor, reducing the uncontrolled cell proliferation of cancer cells containing HER2 receptors.