Principally, the limited access to quality data and the balance of active and inactive reports are difficult the generation of new information and knowledge. However, methods that prioritize the selection of the most representative structure could resolve (almost in part) this issue. Additionally, the implementation of the "Structure-Sequence-Property relationships" concept on peptides is a key step forward to exploiting the potential of peptide data. Besides, the biological issues (i.e., immunogenicity, proteolytic degradation, permeability, and toxicity) have been shallowly explored.