While it is not always necessary for the organic solvent to be fully miscible in water, having a miscible organic solvent is preferred as it offers greater flexibility as any proportion of water to solvent can be used. For this reason, the next step of workflow to identify good organic co-solvents is to determine whether the given organic solvent is miscible with water. Because our aqueous solubility model does not directly predict whether a solvent is miscible with water, we instead sought to identify an aqueous solubility threshold above which solvents can be classified as miscible.