OPLS3e supports membrane simulations and offers optimized parameters for certain lipids: POPC, DMPC (1-2-dimyristoylphosphatidylcholine), DPPC (1-2-dipalmitoylphosphatidylcholine), and POPE (1-palmitoyl-2-oleoyl-phosphoethanolamine). However, to our knowledge the accuracy of lipid simulations in OPLS3e, or its predecessor OPLS3, have not been reported. To examine the performance of OPLS3e and get an insight into how realistic model of lipid bilayers it produces, we simulated pure POPC bilayers at different conditions using the OPLS3e force field. We chose POPC among the OPLS3e-parametrized lipids because of its abundance in biological membranes and the availability of experimental data in the literature.