At the same time as more structures can become thermodynamically viable at lower temperature, such chemistry will naturally be more limited by reaction kinetics. Missing treatment of dispersion effects in B3LYP was corrected for using Grimme's method combined with Becke-Johnson damping (D3BJ). The standard polarizable continuum (PCM) model of Gaussian was used to model interactions with water solvent. Our best estimate to total Gibbs free energies, 𝐺 , , were calculated as