The previously discussed FR maturation predicts novel mesoscale properties of FR products. Thermal decomposition reactions of carbohydrates are known to produce new phases , which sometimes resemble those observed in carbonaceous meteorites . This in silico exploration of the FR independently suggests that such phases form during the course of the reaction as reaction products become new phase-forming products as a function of their mass, cLogP, and estimated aqueous solubility. cLogP is a proxy for the tendency of compounds to partition between hydrophobic and hydrophilic phases, and potentially form new phases. As can be seen, the FR CRNR produces more hydrophobic species as it evolves (Figure ). It might be expected that as general HCHO-derived structures dehydrate, they become more hydrophobic and thus may self-aggregate due to hydrophobic, or other, effects. ESOL (Estimated SOLubility) is a measure of the estimated aqueous solubility of a molecule inferred from its structure based on a QSAR (Quantitative Structure-Activity Relationship) regression model calculated from logP, molecular weight, the proportion of heavy atoms in aromatic systems, and the number of rotatable bonds . Figure shows the estimated evolution of the ESOL trends of the products of the FR CRNR. Higher ESOL values indicate higher aqueous solubility. FR products evolve towards both lower and higher ESOL values as a function of reaction generation in the CRNR.