As a first step in curation, due to concerns regarding noise levels and interpretability, we transformed numeric read count data into a binary variable of active/inactive for each compound. Compounds with read count strictly equal to 0 were assigned a corresponding binary label of 0 and all other compounds were assigned a binary label of 1. Some compounds were labeled as inactive while being reported to have a read count value of 1; to reduce ambiguity these compounds were discarded. The lowest read count value for compounds we labeled as active was 87, which we decided was large enough to minimize the likelihood of false positives.