This work extends other recent work from our group, whose goal is to develop automated methods for reliable and affordable QM calculations in enzymatic systems. Fragmentation offers significant advantages for calculating protein-ligand interaction energies in sizable binding-site models, and renders such calculations accessible to workstation-level computing resources. The open-source Fragme∩t code 30 is a practical and immediate solution that makes accurate QM calculations available to a wide range of researchers who may not have access to supercomputer resources.