The impact of ligand pose quality has recently been examined in conjunction with Schrodinger's FEP+ workflow where it was shown that high quality poses were key to obtaining reliable RBFE predictions. In particular, it was shown that a core constraint derived from a maximum common substructure (MCS) relative to a reference pose could reliably generate poses from which FEP+ results strongly correlated with experimental binding affinities, especially for cases where the consistent binding mode assumption holds.