In collaboration with the Diamond light source (DLS), crystallization and X-ray diffraction experiments were carried out on Nsp5 and Nsp3 compounds. For Nsp5, 148 compounds were soaked at 2 mM and measured by synchrotron X-ray diffraction, which identified 14 potential hits all from the benzotriazolyl acetamide family: Nsp5-1 and Nsp5-7 to Nsp5-19. Comparison to the DLS database (accessible via , use tag 'JEDI -Benzotriazole') showed that several other benzotriazoles had previously been identified for Nsp5. Some representative structures are shown in Figure below. For Nsp3 we found two compounds that could be resolved (also shown in Figure ).