The model code provided by Voronova et al. was reproduced with RxODE2 (v2.1.2). The 2-compartment oral absorption model for AZD4635 was replaced by the following 1compartment model with intravenous administration as given in equations 2. In the model by Voronova et al., the effect was based on the total concentration of AZD4635, therefore, the predicted unbound fraction was not used. ) and variable definitions (Supplementary Table ) may be found in the supplementary information.