The previous modifications at C-3 of the InCs increased their hydrophilicity, which could, in part, account for high instability of NInC hybrids such as that of 12. This can be conceded by virtue of the fact that the more lipophilic 27 is more stable than the less lipophilic 12. To this end, a microwave assisted Heck reaction conveniently brought about the ethyl ester protected 34 from commercially available t butoxyethylene and ethyl 7-bromo-1-H-indole-2-carboxylate, in high yields and purity (Scheme 9) after flash column chromatography purification, as evidenced by H NMR (ESI S54 †).