Lastly, these MAHFs can exhibit large-scale conformational dynamics involving movements of whole domains, a characteristic trait of many proteins. A single mutation was shown to engender reversible, cooperative ligand-triggered conformational switching. This finding motivates the search for other stimuli-responsive dynamic behavior. The simplicity of MAHFs compared to proteins makes them a promising platform to model and better understand metal-protein cooperativity, as well as develop new paradigms of cooperative functionality.