The 9990-child evolved from TTT were DW re-evolved using 9990 as parent (Figure A high number of parent-like star-shaped children molecules, estimated between 10000-30000 molecules per parent, were randomly generated by DW evolutionary fitting the Omicron inner-cavity target defined at earliest SARS-Cov-2 isolates by previous sS. Such enriched numbers of randomly generated molecules were automatically selected for best fitting to the Omicron inner-cavity, and additional criteria including molecular weight and hydrophobicity. The numbers of potentially useful children molecules was downsized by excluding those with DW-predicted high and low toxic properties and nasty functions (~20-74% of the children molecules). Two top-leaders from these children-molecules were selected for a second round of evolutionary fitting. For that, the top-leads chosen to represent two different chemotypes containing one central core of 6atom rings with either two Nitrogens (9990-child) or one Nitrogen and one Oxygen (4976-child), were re-used as parents to generate hundreds of secondary children. Although, despite using this evolutionary powerful approach, most of the corresponding vast chemical/chemotype space fitting the Omicron innercavity still remains to be explored, a similar large number of star-shaped parentlike molecules would have been impossible to retrieve throughout screening of any of the existent public chemical libraries (Mcule, chemSpace, Zinc, PubChem, Chembl, etc).