Our data are strongly indicative that inhibition of the SmBRD3 BRDs has significant effects on three S. mansoni life stages, and studies are ongoing to link the detrimental effects on S. mansoni lifecycle progression and survival to SmBRD3 inhibition. The high affinity small molecule SmBRD3 ligands we have identified provide a firm foundation for the development of further molecular tools that will enable us to investigate the link between SmBRD3 BRD inhibition and the phenotypes observed, providing unprecedented insight into the role of BRDs and epigenetics in the S. mansoni lifecycle.