The efficiency of this method allows us to search through combinatorial spaces that are much larger than the Enamine REAL space. Therefore, we created combinatorial spaces of structures that are synthetically easily accessible through in-house high-throughput medicinal chemistry via up to three steps. These spaces are several orders of magnitude larger than the Enamine REAL space (depending on the specific setup in between 10 12 and 10 15 structures). We are just starting to explore the possibilities of advanced computational methods in cheminformatics and computational chemistry.