Potential oncometabolites including lactate (PubChem CID: 91435), acetate (PubChem CID: 175), lactyl-CoA (PubChem CID: 3081970), and acetyl-CoA (PubChem CID-444493) were retrieved from the database as ligands for molecular docking. The PubChem database was used to download the structure of ligands in SDF format. Then conversion of ligands into PDB format took place using the software OpenBable. Before performing molecular docking, both ligands were energy minimized to obtain stable conformation using Avogadro software with the steepest descent method and MMFF94s force field. Protein Data Bank (PDB) () was used to download the receptor protein. Here, HAT p300 (PDB ID-6GYR) and acetyl-CoA synthetase (PDB ID: 2P2F) were taken as target proteins. Hetatoms are removed from the protein before performing docking. This protein was subjected to the AutoDock Tool 4.2. to perform the steps of protein preparation, which include the removal of water molecules, bond correction, assigning AD4 type atoms, adding polar hydrogens, and adding Kollman charges . AutoDock Vina Software was used to perform molecular docking . After the successful docking, confirmation of the binding position of oncometabolite into the receptor protein and calculation of bond distance has been done by Discovery Studio Visualizer v3.0 (DSV3) and Accelrys software .