Whereas synthetic colors are not originated from the plants or animals, they are made from the different chemicals in factories. They are mostly water soluble and are used in food without any change . In 1856, Sir William Henry Perkin was the first one who developed the first synthetic color and by the turn of century, the use of synthetic colors has been popular throughout the USA and Europe in almost all food stuff like mustard, jellies, ketchup and wine. At that time more than 80 colors were sold of which some were used for dyeing textiles, not for foods. Since the starting 1900s, the most artificial colors were originated from aniline, a toxic petroleum product . Due to more stability its demand is high. In addition, they are less expensive, add no flavor, blend more easily and more concentrated. Coal tar is also a major source from which many of synthetic dye are derived. Much care is required due to synthetic colors are active chemicals . Some of them cause health problems whereas if they are used in large quantity (above the prescribed value) it has carcinogenic effect . In the past, artificial colors were interrelated with hyperactivity in children .