To the best of our knowledge, this platform shows the best control of acidity in the smallest volume reported so f ar. This volume is three orders of magnitude smaller than the last version that we used in our previous publication, as the footprint has decreased to the order of 150 μm. The high f idelity achieved while deprotecting the acid labile groups placed in a glass upstanding the partial cell of our WE, shows the high potential of our platf orm to control addressable chemical reactions. Owing the high level of miniaturization, it would be possible to highly parallelize such chemical reactions, for example, to achieve high density polymer microarrays using parallelized solid phase synthesis.