In order for SERCA to undergo catalytic activity, both calcium and the nucleotide must be bound to the protein . Therefore, understanding the communication pathway between the calcium binding sites and nucleotide is essential to understanding the allosteric mechanisms at work. We computed the shortest path from either ATP or dATP and found that for eight of the nine pathways, the path length is shorter for dATP bound network compared to the ATP bound (Fig. ). The one exception is GLU309 (which functions as a gating residue ), which is extremely close, and likely within the expected error of the path length measurements. However, surprisingly, while almost all of the measured path lengths according to the defined weights were shorter for dATP than ATP, the number of nodes visited along each path was greater for all dATP network paths. Although the individual correlation between ATP and the rest of the SERCA protein tended to be greater than for dATP and the rest of the protein, the intra-protein correlations are higher for dATP, and this is reflected in the shorter measured pathways from nucleotide to residues around Site I and II. We also measured the path length from the nucleotide to GLU340 which has been studied extensively and known to be crucial for interdomain communication and found that dATP also has a shorter measured path than ATP to GLU340. We also carried out non residue-specific global pathway analysis of protein correlation and information flow. Betweenness centrality of each node, which determines how frequently a node appears in the shortest path between other nodes in the network, estimates the significance of a residue in protein communication (figure and). Unsurprisingly, both ATP and dATP had the greatest betweenness centrality, likely acting as a linker between the N and P domains. However, dATP had a much lesser measure of betweenness compared to ATP. Arg236, which lies in the A domain, just at the start of the linkage to helix 3 had nearly the same measure of betweenness in the dATP simulation. This is contrary to the ATP simulation where the protein residues with the greatest degree of betweenness was only one third of ATP. The global pathway results reveal that there is a more uniform distribution of high visit residues for the dATP network as compared to ATP, which dominates the distribution and drops off sharply thereafter. We propose that as dATP promotes the headpiece closure, and induces a more highly correlated structure, it allows for more efficient communication overall, therefore relying less on ATP as the primary residue for information transduction.