The currently proposed bromination reaction, on the other hand, does not require precise control of the orientation of molecules, if the goal is to obtain non-meta-substituted products in order to demon- strate the use of a cavity to enable novel bromination selectivity under standard reaction conditions. As such, randomly orientated molecules strongly coupled to the nano-cavity will bias the selectivity to favor ortho-and para-substituted nitrobenzene products. On the other hand, if the objective is to only obtain either ortho-or para-substituted pure species, then one would either need to control molecular orientation along the cavity field polarization, or separate the mixture of products postreaction, as is common for bromination of activated arenes.