Microfluidic methods offer an exciting alternative to bulk methods for the manufacture of LLCs, that could in principle allow vastly superior control over important parameters such as particle size and composition. Such platforms are modular, easy to use, and highly amenable to industrial level scale-up. Promising research has already been established, though size control and morphological heterogeneity remain critical issues, with some techniques requiring an off-chip post-processing step at elevated temperatures. With this in mind, we present a microfluidic device for the continuous production of lyotropic liquid crystalline mesophase nanoparticles, exploiting the principles of microfluidic hydrodynamic focusing (MHF). Amphiphiles are dissolved in a water miscible organic solvent that is hydrodynamically focused into a thin stream, along which a diffusion gradient is generated. Upon reaching solubility thresholds, amphiphiles self-assemble into micellar structures that aggregate to produce larger assemblies. The nucleation-growth mechanism is controlled via flow rate ratios, and subsequently the hydrodynamic diameters of nanoparticles produced can be finely tuned. Fig. illustrates the series of events in MHF driven lipid assembly.