Assuming Arrhenius kinetics hold across multiple orders of magnitude of temperature for strained systems and the NO 2 bend value of ϕ is relatively stable and constant up to moderate deformations, we extrapolate to thermodynamic conditions past what MD validated here to net physically realistic trends in how the efficiency of mechanochemical kinetics could evolve. Figure present a heat map of 1 k ∂k ∂△U for a wide range of total energy states and activation energies with ∆U set to 200 K. By normalizing by k , this gives a relative change in the rate constant, removing an exponential growth with temperature/energy term. Hence, the coloring is in percent change in kinetics per each kcal/mol of strain energy added (per molecule). Supplemental Materials section SM-4 shows a non-normalized version and a version of both plots in which the color values are based on a value of reaction timescale, not rate (