It is interesting to note how such a shuttling acceleration is related to a higher tendency of increases up to ∼2.9 units as the macrocycle begins the shuttling (vs. 0 units in CHCl 3 /DCM and ∼ 3.5 in DMSO). These evidences confirm that the dynamics of this system follows a clear trend dictated by the solvent propensity to form HBs. In particular, the stronger the propensity of the solvent molecules to establish HBs, the more pronounced is the solute-solute vs. solute-solvent HBs competition in the system.