The scheme was further validated for systems with FG solutes in the AdSoS system. For neutral solutes, the interaction energies and rotational relaxation times of water, as well as the backbone φ ,ψ-distribution of alanine dipeptide, were found to be in good agreement with the FG reference even in the absence of correction potentials. These analyses also suggest that the cutoff radius needs to be scaled with s max , i.e. R c = s max R * c , in order to mimic a FG system with a cutoff radius of R * c . Timings show that a tenfold increase in speed can be achieved in the linear-scaling regime by using the AdSoS scheme to reduce the number of molecules.