One potential side benefit that remains to be explored, despite the challenge of low move acceptances, can be derived from the Jarzynski relationship, which relates differences in free energies between states to the irreversible work done in moving between them. Currently BLUES tracks the work done in turning on and off interactions between the sidechain the surrounding system, regardless of whether an NCMC move is accepted. The accumulation of this data could be used to readily identify favored or unfavored rotamer states in a system regardless of the rate of acceptance, via the Jarzynski nonequilibrium free energy relationship As noted, further studies of lysozyme L99A