From the internal binding energy and entropy, the Hemholtz free energy F=E-TS can be calculated and also broken into conformational modes using the distribution of states. In this overview of Paxlovid, the entropy calculation and discussion is mostly taken from a concurrent paper . The GOLD PLP docking distributions are calculated in terms of score. An approximate linear relation, heuristically valid across + 312 3616 HIS 41 NE2