To further demonstrate the synthetic utility of this method, the resulting tetrahydroisoquinoline-4-carboxylate 2 was utilized to prepare unknown compounds with potential interest as useful building blocks in medicinal chemistry (Figure ). For instance, Suzuki-coupling of 2ax with 3-furylboronic acids readily afforded 4a, simultaneously involving an interesterification of the methyl ester moiety with n-butyl alcohol. Besides, deprotection of N-benzyl with α-chloroethyl chloroformate led to 4b smoothly. Next, Hydrolysis of the methyl esters of 2ax with LiOH.H2O produced β-amino carboxylic acid 4c, and reduction of 2aa by LiAlH4 produced alkyl alcohol 4d in excellent yield (85%).