There are clearly remarkable differences between the three centrality rankings. To pick one example, VAL170 is ranked 14th and 18th in the eand d-centrality, respectively, but was assigned to rank 83 in the b-centrality. Based on the comparison with the PCVA ranking, b-centrality seems to be most promising as it is able to detect a few residues also ranked very high by the PCVA scheme such as ALA66 or ASP140, and it additionally assigns high ranks to residues which are expected to be quite important and which have been previously detected by the CSA and FSA approaches of Kulik and co-workers such as GLU63 or TYR70.