Starting DataWarrior "Build Evolutionary Library" with a home-designed parent molecular pseudoligand The DataWarrior (DW) updated program was downloaded () following the details for Windows as described before . To explore the initial cavity an star-like carbon molecule of C89H180 formula, was drawn in the ICM Molecular editor and saved as a 2D *.sdf file. It will be called here "erizo". After trial-and-error attempts, the final erizo design contained a central carbon branched by 4 arms of 7 carbons per arm, having all carbons saturated with methyls (molecular weight 1249, logP 28.2). After drawing in MolSoft, the erizo.sdf molecule was manually docked to the ORF8 center in PyMol and saved as a *.pdb file to start DW-BEL co-evolutions (Figure up, red spheres and Figure up-left). The DW-BEL fits the children with flexibility around the erizo-supplied cavity, dynamically adapting its cavity to the best fit of the evolving children ligands, as visualized in their *.dwar files.