Degrader 14 was synthesized according to General Procedure A, using thalidomide 4'-oxyacetamide-PEG4-amine. Purification by flash column chromatography, eluting with 0-20% methanol (with 0.5% NH4OH) in dichloromethane over 20 cvs, afforded the title compound as a colorless oil (25 mg, 55%). Purification by flash column chromatography, eluting with 0-20% methanol (with 0.5% NH4OH) in dichloromethane over 20 cvs, afforded the title compound as a colorless oil (28 mg, 65% A microwave vial was equipped with a magnetic flea and flushed with argon. 4-(2-aminoethyl)-1-Bocpiperazine (5.05 g, 22 mmol) was added followed by triethylamine (15 mL). This was stirred for 3 min before the addition of 4-fluoro-3-nitrobromobenzene (4.40 g, 20 mmol). Following addition, the vial was sealed and heated using the dynamic heating method, with max. power set to 300 W, max pressure 300 psi, max temperature 125 °C, high stirring throughout and power max turned off. This method was used to hold the temperature at 125 °C for 10 min. After cooling, the reaction mixture was transferred to a separating funnel where it was partitioned between water (250 mL) and ethyl acetate (200 mL).