We construct a cubic simulation box of edge length ~3.6nm. Subsequently, the simulation box is filled with the solvent and co-solvents accordingly. We have generated five different systems for this investigation, by varying the concentration of co-solvents urea and choline chloride along with the solvent water. These systems are, W: bulk water (represented in orange), W-UC (2:1): aqueous solution of 2M Urea and 1M choline chloride (represented in black), W-UC (4:2): aqueous solution of 4M Urea and 2M choline chloride (represented in red), W-UC (6:3): aqueous solution of 6M Urea and 3M choline chloride (represented in blue), W-UC (8:4): aqueous solution of 8M Urea and 4M choline chloride (represented in green). The aforesaid color codes for these different systems are maintained throughout the manuscript. Detailed information for each system is provided in the supplementary information (Table ).