Our customized chemical space shows highly increased docking scores. REvoLd's evolutionary optimization results in molecules exceeding the scores of previous results by far. The reported high scoring molecules show clear resemblance to the known actives used as seed molecules. In particular the resulting compound for the Orexin 1 receptor is promising, since it increased noticeably in size from known actives and thereby more closely resembles the large peptide that natively binds to the receptor. The compounds for Tyrosyl on the other hand are less convincing. They are more fragment-like and highly charged. However, the high scoring known actives used as seed molecules are small and polar as well, so this could be more a problem of the scoring function deployed for this target. We found the scoring function tends to overrates polar interaction and thus has a propensity to guide the evolutionary optimization towards even more charged compounds.