The above observations are in coherence with a recent finding that the lactylation process modulates the transcriptional gene regulation in M1 macrophage and allows it to change into M2 macrophage . Zhang et al. 12 discovered the process of lactylation with experimental evidence at molecular and cellular levels. However, pertinent questions were not answered on the nature of the enzyme and biological source and relevance of lactyl-CoA that may potentially act as a substrate for a potential enzyme such as HAT p300. Our data is the first and novel proposition on the biological possibilities of lactyl-CoA within the tumor microenvironment and the mode of lactylation mediated by the HAT p300 enzyme.