Taurine distribution is organ specific with the highest concentrations found in the retina, leukocytes, platelets, heart, skeletal muscle, and brain 1,2 .Since erythrocytes have a significantly lower concentration of taurine than these tissues, we posit that the formation of a peptide bond between taurine and the C-terminus of a1-CT-Y in ChET is the action of a tissue specific enzyme that is yet to be described in this role.