Finally, we discovered that the palladium-catalyzed Tsuji-Trost reaction under the current reaction conditions fit Michaelis-Menten kinetics. Michaelis-Menten kinetics in transition-metal-catalyzed reactions were discussed in literature, although scarcely. This is surprising, since Pirrung and co-workers stated that there might be many such reactions. The saturation kinetics experiment depicted in Figure shows that increasing the RAE concentration up to ~120 μM will linearly increase the reaction rate. Scheme 3a (general equation for Michaelis-Menten kinetics) can be applied to Scheme 3b, in which the p-allylpalladium complex is equivalent to an enzyme-substrate complex depicted in the original paper by Michaelis and Menten. Scheme 3. (a) Typical enzyme-catalyzed reactions with Michalis-Menten kinetics. (b) Analogy of the current method to Scheme 3a.