iii) The highest DW and ADV consensed affinities were predicted for FtsZ and Sglt2 (corresponding to lowest <10 nM ADV docking-scores). Sglt1 and Vegfr have only a few children predicting high affinities (< 10 nM ADV dockingscores). In comparison, the top-leads corresponding to Nkcc1, Hsp47 and P2x3r, predicted lower ADV affinities (corresponding to high ~10 2 -10 4 nM docking-scores). PyMol drawings were generated for each of the target / parents (Figure , gray cartoons and red sticks, respectively) and compared to their ADV 10 top-lead children (Figure , green sticks). Comparisons of 2D structures between parents and their best top-lead children molecules were also compared in MolSoft (Figure ).