shows the correlation plot between E nelec and dispersion interaction energy E disp calculated using two well-established methods: In summary, we demonstrated that the extensive structural and property data contained in AQM dataset hold the potential to enhance the understanding of how molecular-solvent interactions influence both structure-property and property-property relationships of large drug-like molecules. As such, AQM may in some cases be employed as a benchmark dataset for direct/delta learning and generative methods, estimating the properties of pharmaceutical compounds in solution from their gas-phase counterparts.