Human rhinoviruses (RV) are the principal cause of the common cold, and account for the majority of upper respiratory infections in children under 5 years . The second most prevalent viruses responsible for the common cold are the seasonal human coronaviruses (CoV): HKU1, OC43, NL63 and 229E . Beyond those that cause relatively mild disease, three CoV strains have been responsible for severe disease outbreaks in humans: Severe Acute Respiratory Syndrome (SARS) by SARS-CoV-1, Middle East Respiratory Syndrome (MERS) by MERS-CoV, and most recently Coronavirus Disease 2019 (COVID-19) by SARS-CoV-2 . Another agent typically associated with mild respiratory infections are adenoviruses (AdV), although they can also cause severe respiratory illness .