We demonstrated that AO is possible in both organic and aqueous solvents with a host-guest approach. Moreover, we were able to improve upon the HG system we previously reported by incorporating a more stable binding group on the catalyst backbone. The newly designed system displayed increased performance considering different aspects such as stability and faradaic efficiency. This is due to the increased stability of guest 1 at high pH due to the better binding to the host and the earlier onset potential for AO resulting from the different electronic effects on the Ru center from the ligand. Moreover, we found that ammonia oxidation is possible in water as a solvent, without any further supporting electrolyte or buffering system, which demonstrates the increased stability of the system towards higher pH (>11). Different solvents led to different products, with NO3 -being the sole product in H2O with up to 98% FE. The recyclability of the host-anchored electrode was demonstrated by the reabsorption (up to 3 times) of new guests without a loss in catalytic activity.