Given the potential impact of beam-induced lattice reorientation on MicroED data quality, particularly from beam-sensitive molecules, we sought to determine strategies for the optimal collection of MicroED data. To do so, we collected multiple subsequent datasets on single crystals, covering the same wedge of angular rotation repeatedly on each, with an incident flux of either 0.01 or 0.03 e -/Å 2 s, and compared the data reduction statistics each yielded.