After confirming that they were completely dissolved, the solid dispersion powder was prepared using a production-scale spray dryer. The conditions for production were an outlet temperature of 50 °C, feed rate of 80 kg/h, and spray pressure of 2.5 bar. Obtained solid dispersion powder was dried in a vacuum dryer for 37 h. The batch size of tablet manufacturing was 20 kg/batch. S-892216 amorphous solid dispersion, mannitol, microcrystalline cellulose, croscarmellose sodium and sodium stearyl fumarate were mixed using a blender for 15 min. The mixture was sieved through a screening mill with a 1.6 mm opening screen (Quadro Comil 197S, Powrex Corporation, Hyogo, Japan) and, subsequently, dry granulated using a roller compactor at the pressure of 3-7 MPa. Ribbons were sized using a 20-mesh screen. Sodium stearyl fumarate was added to the milled granules. The mixture was lubricated for 3 min using a 60 L V-blender. The final blend was compressed using a rotary tablet press with an oval-shaped punch (long axis = 14.0 mm, short axis = 7.3 mm). Film coating was performed using a pan-coating machine. The conditions for production were an inlet temperature of 60 °C, feed rate of 40-80 g/min, and spray pressure of 0.4 MPa.