To evaluate our proposed approach, we curated a selection of 17 datasets from publicly available HTS data, for a total of 471370 unique compounds measured against 10 different protein families, using a variety of readout measurements and activity thresholds (Table , Table , Table and Table ). False positive rates range from 11% to 91% and the screened libraries evaluate different regions of the chemical space (Figure ), thus covering a broad spectrum of HTS campaigns.