CACHE will organize hit-finding challenges that represent the range of common scenarios encountered in hit-finding depending on available target information (FIG. , Panel B). A Target Selection Group will select targets appropriate for each of these 5 scenarios. Specifically, the Target Selection Group will define the acceptance criteria for targets in each scenario, bioinformatically create a "long list" of targets that meet these criteria, and create a mechanism(s) for the community, including the funders of CACHE, to prioritize from this list those targets to be included in the launched benchmarking challenges.