High Performance Liquid Chromatography (HPLC) analysis. HPLC analysis was carried out using a prominence LC-20A modular HPLC system (Shimadzu, Duisburg, Germany) equipped with a system controller CBM-20A, a solvent delivery unit LC-20 AT (double plunger), an on-line degassing unit DGU-20A, an auto-sampler SIL-20AC, a photo-diode array detector SPD-M20A, a column oven CTO-20AC, and a refractive index detector RID-20A. As stationary phase, a ZORBAX Eclipse Plus, Agilent (Santa Clara, CA, USA) C18 column (4.6 x 100 mm; 3.5µm50mm x 4 mm) was used. The volume of samples injected was 20 μL and elution was performed using a mobile phase of H2O and acetonitrile (ACN) containing 0.05% trifluoroacetic acid (TFA) at 40 °C and a flow rate of 1 mL/min. Quantification of paclitaxel (PTX) and ibuprofen (IBU) was performed at 220 nm. For PTX, within the first 10 min, the proportion of ACN was increased from 40% to 60%. Solvent proportion was kept constant for 5 min prior to decrease it to initial proportion of 40% ACN within 0.5 min. For IBU, the proportion of