Moreover, the system with 1 Syt1-C2B has the widest water channel (and the highest values of ξ e ) with the lowest amount of surrounding lipids. On the contrary, membranes-only system has the narrowest water channel (though the lowest values of ξ e ) surrounded by the largest amount of lipids (see panels 6c and 6d). Interestingly, the system with 2 Syt1-C2B