The application of nanotechnology is particularly exciting in the realm of biotechnology, where living cells can be interfaced with synthetic materials to achieve novel functionalities. Singlecell nanoencapsulation (SCNE) has great potential in augmenting the properties of individual cells by imparting orthogonal functionalities via decoration of the cell surface with non-natural molecules, effectively modifying the phenotype without altering their genetic makeup. This has already been explored on microbial and animal cells. Yeast cells, in particular, have proven to be a versatile subject for SCNE due to their broad range of biotechnological applications. Being a model organism, the well-known yeast surface display of enzymes on the membrane of S. cerevisiae provides a platform for in-situ enzymatic reactions, for instance with the enzyme horseradish peroxidase (HRP). Previous studies have reported the grafting of polymer chains onto living yeast cells through copper-catalysed atom transfer radical polymerization (ATRP), or photoinduced electron transfer-reversible addition-fragmentation chain-transfer polymerization (PET RAFT). However, the conditions used were relatively harsh and not easily scalable. ATRP and RAFT polymerizations can also be catalysed and initiated by enzymes such as HRP, haemoglobin or laccases. As such enzymes can be produced by the cells themselves, bioATRP and bioRAFT polymerizations should be ideally suited to grow polymers on cell surfaces and therefore engineer the surface with enzymatically synthesized non-natural polymers.