The projections of the three datasets on a common 2-dimensional space using Multi-Dimensional Scaling (MDS) (Fig. , see SI for details) shows that NiCOlit is more spread out than HTE data. The distributions of the pairwise Jaccard distances between the reactions of each dataset were also computed (Fig. ) and corroborate the MDS analysis: distances between NiCOlit reactions are on average higher than in HTE data.