In summary, the drawback that this technique is not scalable is very problematic and hinders the commercialization of CSHNs. These limitations of the two-step technique forced the scientific community to combine the two steps into one and formulate the so-called onestep technique. For this reason, the one-step technique has proven to be a simpler and more efficient synthesis method compared to its two-step counterpart. In this technique, whose name is self-explanatory, CSHNs are prepared in a single step by the reaction of lipid solution and polymer particles with nanoprecipitation or emulsification by solvent evaporation. The fundamentals of these two methods, which are the most important aspect of the process, are explained below .