Currently, preclinical studies rely heavily on cell culture and animal models . Cell culture in well-established containers such as flasks, Petri dishes, and well plates is simple, scalable, relatively cost-efficient, and yields fast results. Nonetheless, growing cells in a 2D monolayer on a flat surface does not provide in vivo cell-cell and cellextracellular matrix (ECM) interactions, and thus may not represent human physiology.