Once the T-cells are activated, they can differentiate, increase, and execute immune functions like cytokine production and cytotoxic activity to combat infections . Prostate Stem Cell Antigens (PSCA) are surface proteins considered a biomarker and therapeutic target for prostate cancer in prostate epithelial cells . PSCA is responsible for regulating cell proliferation and adhesion, thereby having elevated levels of these proteins to be associated with the incidence of prostate cancer . T-cell Receptors are found on the surface of T-cells, consisting of two protein chains -an alpha (α) and a beta (β) chain -as shown in Figure . Each chain contains two regions: variable and constant . The variable region differs highly among various T-cells, and its mechanism is to recognize and bind to specific antigens located on the MHC molecules in the antigen-presenting cells . Meanwhile, the constant region is responsible for TCR's structural components and signaling capabilities. Overall, this structure enables TCRs to identify and respond to numerous pathogens in an immune response .