There is a general interest in developing stimuli-responsive systems due to their ability to modulate their functions in response to endogenous signals or external stimulations . A widely used strategy to convert a passive system into a responsive one, consists in tethering a stimuli-responsive group, such as a photochrome, a pH-sensitive group or a redox species through adequate covalent modification. With the repertoire of known chemical reactions and coupling methods, this powerful approach can lead to virtually any user-defined system designed to respond to a desired stimulus. However, the necessity of covalently modifying the entity to be stimulated can alter its properties. It also requires to adjust the modification conditions for each system, making the approach case-specific. Stimulus-responsive selfassembly of molecular bricks through non-covalent interactions appears as an interesting alternative as it opens the possibility of dynamic actuation of inherently passive molecules without needing to modify them. This approach has already been demonstrated relevant for a large number of applications ranging from chemical sensors to drug-delivery systems . The resulting stimuli-responsive self-assembled systems are of particular interest when involving biological molecules to dynamically control their functions . Among biologically active molecules, nucleotides and analogues appear as particularly interesting targets for such a purpose . For instance, adenosine 5'-triphosphate (ATP) is the universal energetic and ubiquitous molecule driving biological processes such as cellular division and whose concentration can correlate with pathological conditions, for instance in Parkinson's disease .