Force fields are self-consistent entities. That is, each one has an established method for parameter development, often targeting quantum mechanical (QM) and empirical data. Moreover, these force fields are developed with specific algorithms used to compute bonded and nonbonded forces. Lastly, error cancellation may be important in the context of properly balancing intermolecular interactions. Ultimately, there are several aspects that users control when running a simulation that can undermine the validity of the chosen force field, perhaps unknowingly.