In the bigger picture of the clinical translation of MOFs, biocompatibility is undoubtedly a crucial consideration. An equally important consideration is that of stability, both under storage and physiological conditions. While again, it is possible to extract chemical trends related to stability based on chemical intuition, and experimental data, these may not be generalizable, especially in biological contexts, due to the inherent complexity of biological systems. While discussions pertaining to stability are largely outside the scope of our current analysis, we refer readers to dedicated reviews on this topic. Perhaps the most interesting recent development with regards to the clinical translation of MOFs is the advancement of external surface functionalizationas briefly discussed earlier. These external surface modifications have improved colloidal stability, enabled controlled payload release, facilitated targeted delivery, and improved the biocompatibility of MOFs. For a comprehensive discussion of external surface modifications, we refer readers to our recent review.