It is consistently found by the descriptor-based SHAP analysis as well as by the X-FP analysis that basic moieties are driving a compound to be lysosomotropic. Though we restricted our selected compounds to be within a certain PhysChem window (logP > 2, bpKa between 6.2 and 11), this lead to a restriction of the entire data towards basic moieties. However, the XML still might not have been capable of identifying this bias, but they correctly identified the fact that basic moieties are relevant for lysosomotropism.