The role of adhesion GPCRs has been properly established.in immune defense, cancer and neurodevelopment. However, their role in viral infections was explored in a recent study in which human epithelial cell lines were infected with SARS Cov-2 and the mRNA levels of adhesion GPCRs were analyzed which lead to the discovery of four adhesion GPCRs out of which ADGRD1/GPR133 and ADGRG7/GPR128 displayed the largest increase in mRNA levels.