We have shown that VSC can result in catalysis of TA reactions. We have presented an MLJ model to study charge transfer processes under VSC (in passing, these results suggest a VSC alternative to enhance charge conduction, which has so far been only considered in the electronic strong coupling regime ). In this model, there is a range of molecular features where the shrinkage of the activation energy of the lower polariton channel can outcompete the rate associated with the massive number of dark-state channels. This model describes a mechanism suitable to be present in a wide variety of thermally activated non-adiabatic reactions, e.g., electron, proton, and methyl transfer, among Fig. Electron transfer parameters for catalytic behavior. The lower polariton (LP) channel dominates the kinetics over the many dark (D) channels for these values of ΔE (the energy difference between product P and reactant R), λ S (the classical reorganization energy), and Δ (the detuning between the cavity and the high-frequency mode of the product). In a we explore the three variables, whereas in b we show the cross-section under the resonant condition. For these calculations, the reactant and product modes have equal high-frequencies ω R ¼ ω P , k B T ¼ 0:2_ω P , N ¼ nge of molecular parameters where the energy of the lower polariton channel ssociated with the massive number of etermined that these effects are most conditions. This finding is relevant, as ed in experimental reactions performed ark, however, that the latter are prebatic reactions and the involvement of s not obvious (for a recent study on does not offer a reduction of reaction rate coefficients for a broad range of parameters; after all, if the polariton channels do not provide incentives for their utilization, the dark states will still be accessible, leading to virtually unaffected reaction rates as compared with the bare case. However, an experimental suppression of reactions by VSC under TA conditions (as in refs. ) could correspond, microscopically, to the polaritonic modification of elementary step rates in the network of reaction pathways that comprises the mechanism. Second, it is not evident whether the state (orange solid line) |P J ⟩ is in the Marcus inverted regime. Due to the light-matter coupling between âB and âc two light-matter hybrid states, lower and upper polariton states, are formed which are indicated as red and violet solid lines. The relative driving force between the reactant state and the lower polariton thus depends on the light-matter coupling √ N g where N is the number of products. Thus the chemical rate increases as more products are formed. Meanwhile, the relative driving force between the reactant state and (N -1) excited vibrational dark states (green solid line) remains the same as the uncoupled case. The chemical rate modification as a function of the light-matter coupling √ N g and the detuning ∆ = ω c -ω p , where ω p is the frequency of the vibrational mode on the product state, is shown in Fig. . The bell-shaped rate curves are because as the Rabi splitting increases, the activation energy of the lower polariton decreases, thus making this channel dominant. The authors find a parameter range where, despite the vastly greater number of dark-state channels (N -1) than polaritonic ones, the latter controls the reaction's kinetics due to their lower activation energies. Using a similar model system, Ref. 436 showed that such non-adiabatic ground state electron transfer reactions can also be suppressed in addition to being enhanced as shown in Ref. 36. The authors in Ref. 436 point out the two main factors in modifying such reactions: (i) through the modification of the driving forces due to the shifts of the energy levels induced by the light-matter coupling and (ii) through the modification of the Franck-Condon factors that rescale the diabatic coupling. They find that when the cavity coupling for the reactant and product states differ significantly from each other (as was the case in Ref. 36) the cavity coupling leads to an increase in chemical rate. On the other hand, when cavity coupling for the reactant and product states are similar in magnitude the modification of the Franck-Condon factors leads to suppression of chemical kinetics, especially at ultra-strong vibrational coupling regime.