The concept of regrettable substitution first appeared in the literature in 2011 . There are many examples of regrettable substitution, which refers to the practice of replacing a hazardous substance with a structurally similar substance for a specific use or function, that is also hazardous or potentially more hazardous, or that has not been tested broadly enough for different hazards and other than those of the substance being replaced . One well-known example is Bisphenol A, an endocrine-disrupting chemical (EDC) that was first discovered in 1891 . Due to its harmful effects, it has since been replaced by various other EDCs with similar structures such as Bisphenol S and Bisphenol P. Currently, more than 30 bisphenols, including the ones mentioned above, are recommended for restriction by ECHA .