Some of these points were around the equilibrium of the stationary points, and the remaining were well dispersed along the MEP. Then several preliminary correction PESs were obtained by fitting the energy differences between high-and low-level energies of these points, four best fittings were chosen to calculate the average energy difference among them, namely, For the computation time on the clusters with Intel Xeon CPU E5-2680 v3 @ 2.50 GHz processors, computing 75300 M06-2X/AVTZ points needed about 3140 hours and the CPU time for 10700 UCCSD(T)-F12a/AVTZ points was 16050 hours. Consequently, building PESH only takes roughly 17% of CPU time for calculating 75300 UCCSD(T)-F12a/AVTZ points directly. The RMSEs for VLL, ΔVHL-LL, and VHL are 0.20, 0.13, and 0.17 kcal mol -1 , respectively. The PIP-NN based Δ-ML approach can be used to develop full-dimensional PESs of large molecular systems efficiently. In addition, one can improve previous PESs by adding more and more corrections gradually, 208 which is invaluable for the science community of developing PESs and related fields.