To tune our methodology, we initially decided to repro- duce the absolute free energy of solid α-methanol, one of methanol's polymorphs, at 150 K using EMM before doing the same calculations for our compound of choice, ASA. We verified that the free energy differences between the Einstein molecule and the interactive Einstein molecule (∆A E M →I E M ) and between the latter state and the solid (∆A I E M →solid ) were more reliably estimated with the multistate Bennett acceptance ratio (MBAR). The absolute free energy of the crystal (as computed for united-atom OPLS α-methanol) agreed with results found in the literature, which suggested that we were on the right path. We did, however, require a very large number of intermediate alchemical states to obtain accurate free energy estimates, making these simulations fairly computationally demanding.