To ensure a fair comparison, all methods were set to use a metadynamics length of 30 ps, using the -mdlen 30 keyword. The results are shown in Table (binding energies) and Table (number of conformers generated within 6 kcal/mol of the lowest-energy conformer found by that method). In the SI, we provide xyz structures of the lowest-energy geometry found by each method for each test. Also in the SI, we report the number of core-hours required for each test, to allow comparisons of the relative efficiency of each method. These tests revealed a bug in the V4 method of CREST, where if a new, lower energy conformer is found during the static metadynamics (sMTD) phase, the algorithm terminates without recording the new, lower energy conformer, instead of restarting from the new conformer. In only three cases did V4-CREST complete without triggering this bug: dimer 17-18 and single molecules 23 and 24. Interestingly, in the cases of 23 and 24, the results of V4-CREST were inferior (higher in energy) to both CREST and LEDE-CREST, and in the case of the 17-18 dimer, they were comparable, with an energy equal to that given by LEDE-CREST, and less than 0.1 kJ/mol better than that given by CREST, and with three conformers reported vs two for each of the other methods. The CREST authors have been informed of the bug, and they promised to fix it in CREST version 3. CREST version 3 27 was published while this article was undergoing peer review. We have not yet tested it to see if the bug in V4 is fixed. If it has indeed been fixed, then V4, which is conceptually similar to LEDE-CREST, though different in intent, may become competitive with LEDE-CREST for clusters of flexible molecules, so long as a constraining potential is added.