The experimental data are depicted as mean values accompanied by their standard error of the mean (SEM, derived from no fewer than two independent experiments. Statistical analyses were conducted using a two-tailed, unpaired Student's t-test with Prism software (version 8.0, GraphPad Software, San Diego, CA, USA). Significance levels were set at p < 0.05 (*), p < 0.01 (**), and p < 0.001 (***), with "ns" denoting non-significant differences between the indicated settings.