Analysis was performed using a Vanquish Flex binary UHPLC system (Thermo ScienNfic, Germering, Germany) coupled to an Orbitrap Exploris 240 mass spectrometer (Thermo ScienNfic, Bremen, Germany) for the discovery phase and an Orbitrap Exploris MX mass detector (Thermo ScienNfic, Bremen, Germany) for the monitoring phase. The system was controlled via Chromeleon CDS, version 7.3.1 for data acquisiNon and data analysis including the NPD funcNon. MS/MS data analysis and the creaNon of the pepNde workbook were performed using Biopharma Finder, version 4.1, (Thermo ScienNfic, San Jose, CA, USA).