It is evident that the study of chiral MOCs will remain a dynamic field of research and a crucial facet of supramolecular chemistry and materials science in the future. At the fundamental level, rational design of the chiral building blocks with precise positioning of functional groups is necessary to achieve the preparation of functional MOFs. Additionally, the topic of inducing chirality in MOCs by the assimilation of achiral building blocks is emerging, and while its promise is just beginning to be shown, a major barrier still stands in the way due to the lack of appropriate generic chemical manipulations.