While CoPhMoRe promises to be a universally tunable recognition sequence, one main bottleneck of using highly sensitive nanomaterials are small perturbations (from unspecific binding) that result in high signal changes. To circumvent this problem, it is possible to i) tailor the rigidity of the soft interfaces at the nanosensor surface or ii) use multiple nanosensors in a multiplexed format . It is possible to combine covalent surface modifications (sp -defects/OCC: organic color centers) and non-covalently adsorbed polymers (Figure ,f) to expand the chemical space. Additionally, different linking strategies can be combined and the recognition unit can be constrained to bridging anchor molecules on the surface of a SWCNT.