The importance of minimising overzealous use of PGs in synthesis is best delineated by the confusion that can result when PG strategy has been assumed, wrongly, as the synthetic chemist's go-to strategy, or established erroneously; this is so because the most practical and best total syntheses i.e. the 'ideal syntheses' are those with no or, at the very least, minimal PG contribution. Scheme 6. Synthesis of NInC 27.