(Figure and). That said, given the p-values associated with these two mutated residues are 0.017 and 0.026 respectively, it is likely this region of the protein is more stable in Chimera 3 than in wild-type YopH (note that the use of Benjamini-Hochberg correction 1995) for multiple statistical tests means that p-values <0.05 are not automatically considered significant, see the Supplementary Methods section for further details).