Zeolitic Imidazolate Framework-8 (ZIF-8) is a class of metal organic frameworks (MOFs) which were synthesized as described in the experimental section (ZIF-8(1), ZIF-8(2), ZIF-8(3)) and analyzed for reproducibility. MOFs in general and ZIFs in particular are of great interest due to their simple synthesis and versatile applications . The DLS measurements were performed with the refractive index for ZIF-8 set to 1.355 49 which gave monodispersed and similar size distributions across all three batches as represented in Figure . Mean sizes and standard deviation across three batches were measured at 592.5 ± 40.6 nm for di, 629 ± 50.9 nm for dv, 543.6 ± 19.9 nm for dn and 648.1 ± 19.7 nm for Z-average, which shows a low variability between batches (see Figure (a-b), Figure ). Further, the morphology of the ZIF-8 samples was analyzed by scanning electron microscopy (SEM) and transmission-mode scanning electron microscopy (tSEM) (Figure ). The images show crystalline, well dispersed particles with clearly visible crystal facets. The particle size distribution obtained from the images were consistent across the three batches (Figure ). The mean particle size for the three batches was measured as 351.1 ± 14.7 nm, which shows a low standard deviation between batches, as is also represented in 4118891) confirming a ZIF-8 structure with a sodalite (SOD) crystal phase . Interestingly, the peak shape is somewhat asymmetric, and there are small shifts in the peak positions, which will be further investigated in the future. reaction was assessed for core-shell nanoparticle syntheses. Au@SiO2 nanoparticles were synthesized as described in the experimental section. Since the size distribution of AuNPs as described above were extremely similar for different batches, we were able to combine several batches and use the resulting dispersion as the cores. This procedure can help to avoid the need to up-scale the reaction. The synthesized core-shell particles were analyzed by TEM (see Figure (c)), which showed a monodisperse population of spherical particles, very well spread out on the grid, with a thick mesoporous silica shell and a small gold core. The size distribution recorded from the images, represented in Figure , resulted in a mean particle size of 101.7 ± 8.7 nm. The extremely homogenous population of Au@SiO2 particles is further indicative of the high reproducibility of synthesis with the SDL which allows for combining of reaction products.