We created an extensive benchmark set named Papyrus, that contains high quality data aggregated from multiple data sources. This standardised set is primarily used as a reliable data source for modeling ligand-protein interactions. We have shown the statistics of the Papyrus dataset and several classification and regression models using QSAR and PCM, with performance on par with prior results. We anticipate that the Papyrus dataset can be exploited in a myriad of ways and filtered or altered for specific research questions. We believe the strength of the dataset lies in its standardisation, normalisation and quality, while providing the necessary tools for further manipulation to specific needs.