The different methods are compared for 60 additional solvent/solute pairs in the supporting information (Figure ). While the temperature dependence of the solid solubility is predicted well for most pairs, there is one pair, namely 5-fluorouracil in water, whose predicted temperature gradient shows an opposite trend (∆H diss,T < 0) with the experimental data. It is found that the sublimation enthalpy of 5-fluorouracil is substantially underpredicted by our model as 20.8 kcal/mol compared to the reported experimental value of 31.8 kcal/mol. This experimental ∆H sub,298K value is used to recalculate log(S X,T ) according to Eq. 11, which significantly improved the model performance (see supporting information Figure ).