In the literature, it has been reported that achieving optimal BD yield requires the presence of active sites that are uniformly distributed with the appropriate balance of acidity to promote all the reactions involved in ETB. Additionally, other studies have demonstrated the use of twoor three-element catalysts to achieve this balance, albeit with only moderate BD yield and selectivity. The present study, however, unlocks the potential of catalyst exploration within a vast catalyst space by utilizing GA-driven HTE. This top-down approach solves the challenge of optimizing the intricate reactions in a single-bed reactor by simultaneously optimizing the loading amounts of multiple elements onto the support. The catalysis space comprises elements known to catalyze EtOH dehydrogenation (Zn, Ag, Cu, Ni, Cr, Ga), aldol reaction (Mg, Zn, La, Hf, Y), MPV reaction (Mg, La, Y, Zr), and EtOH dehydration (Mo, Nb, Al). The choice of the supports is very crucial in determining the performance and sustenance of the catalysts. The high surface area as well as the large pore size of SBA-15 not only enhances the dispersion of the active sites but also prevents the deactivation of the catalysts due to coking. In this study, a total of 276 catalysts were evaluated, which were distributed among 17 generations of GA and are listed in Table . The catalysts were evaluated in a uniform and process-consistent manner using the HTE instrument. Among the ten reaction condition sets tested, the temperature of 400 °C and the 𝑃 !"#$ /𝑃 %& ratio of 0.09 predominantly yielded the highest BD yields (see Table ). Accordingly, this particular condition set was used to determine the fitness of the catalysts in GA and for data analysis purposes.