Despite the insights this initial PDF analysis provides, it does not yield information on interfacial interactions; these can potentially be deduced through the use of principal component analysis (PCA), Non-Negative Matrix Factorisation (NMF) or differential PDF. However, challenges arise with these approaches because of the small interaction volume between the two components relative to the bulk of the material and care must be taken during data interpretation. Here, multiple linear regression (MLR) analysis was performed on the total scattering data, which has previously been applied to X-ray diffraction patterns to assess the surface area of mesoporous materials and on X-ray fluorescence spectrometry data. The blend samples were fitted using the two PDFs of the starting materials. Intuitively, the blend PDFs can be thought of as a combination of the starting materials' PDFs in varying proportions, with a potential interface between them. However, careful data interpretation is required as only two PDFs are used for the fitting and some of the interface's contribution to the blends' PDF could be inadvertently fitted.