Chemical design iniVaVves for PLs have typically fallen into two main categories: (i) a brute-force screening approach -large-scale candidate tesVng based on resource availability or chemical intuiVon; 9,10 or (ii) a down-selecVon or filtering approach -sequenVal constraints are placed on candidate combinaVons to decrease design space. Each of these approaches is limiVng. For example, brute-force screening approaches like that reported previously for imine POC based type II PLs is resource-and Vme-intensive, requiring extensive synthesis and use of low accuracy measurements to increase throughput. Whereas high-performing candidates may be inadvertently excluded within a down-selecVon or filtering approach. Further, current computaVonal methodologies employ several assumpVons, which can limit their uVlity across PL formulaVons. Thus, alternaVve methods are required to assess the viability of potenVal pore carrier/solvent combinaVons.