In addition to capturing metrics per injection or experiment, it is essential to monitor these metrics longitudinally. These QC metrics can vary by LC column chemistry and flow rates, data acquisition type, and instrument platforms, and so defining acceptable margins is imperative 2 . It may be that some acceptable range of +/-15 % of a QC metric is acceptable, but anything more than this would need the run to stop (a go/no-go metric). Defining these margins truly relies on an operator's knowledge and experience with their specific setup and how these quality metrics manifest in the final data analysis (i.e., there are some metrics that do not have universal thresholds for QC). Being able to track values across long periods of time will invariably help if troubleshooting the system is needed, or to determine the need for periodic maintenance. This is also a case when sharing data between labs of the same material and same data acquisition can be helpful, since this way performance and quality can be compared.