Complexity descriptors (Table ), sp 3, and chiral carbon fractions of COCONUT's compounds were 0.57 and 0.18, and for LANaPDB's compounds were 0.59 and 0.21. These values are similar between NPs compounds though LANaPDB compounds were the most complex presenting the higher mean in both descriptors. The sp and chiral carbon fractions of COCONUT's compounds were similar to the "Fragments RO3" of COCONUT (0.55 and 0.14). A difference was observed with the COCONUT fragments with a higher fraction of sp 3, carbons (0.64) and fraction of chiral carbons (0.29). The sp 3 (0.6) and chiral carbon (0.17) fractions of LANaPDB compounds are more similar to the values obtained for LANaPDB's "Fragments RO3" (0.6, 0.17) and LANaPDB's fragments (0.71, 0.32).