In this work, we focus on predicting HAT reaction barriers within one particular protein system, collagen (Figure ). As shown earlier by some authors of this article, stretching collagen generates mechanoradicals within the protein. These radicals rapidly localize on specific protein residues, dihydroxyphenylalanine (DOPA), plausibly through a sequence of HAT reactions. Insights into the reaction pathway of radicals might help in the design of similarly durable polymer systems as collagen but are experimentally challenging to obtain. Our work is an important step towards predicting radical reactions in collagen. However, as we show in addition, the model is also applicable to proteins of different composition. We also suggest the developed workflow to be straightforwardly applicable to other, not necessarily biological, polymers.