Before commencing the optimization campaign, we initially synthesized the terpolymer from Styrene, Myrcene, and DBI to confirm its formation. An equimolar feed ratio of all three monomers was subjected to a reaction conditions and stirred at 80°C for 4 hours in the presence of AIBN. Samples were collected every 30 minutes to monitor the depletion of individual monomers. As illustrated in Figure , the monomers were steadily consumed, resulting in an overall monomer conversion of approximately 55%. The reaction mixture was gradually added dropwise to methanol for the precipitation of the terpolymer and analysed. Gel permeation chromatography (GPC, Figure ) plot displayed unimodal and symmetrical traces at a shorter retention time of 15.9 min. The formation of polymers with number average molecular weight (Mn) 14150 Da and polydispersity index (Mw/Mn) of 1.8 indicated the formation of higher molecular weight compounds. The incorporation of styrene, myrcene and DBI was confirmed by analysing 1 H NMR of the precipitated polymer. The broad peaks observed at 7.2 ppm, 5.0 ppm and 4.0 ppm are respectively assigned to the protons of styrene, myrcene and DBI. The peak area integration of these peaks indicated that styrene, myrcene and DBI are incorporated in the resultant terpolymer in the ratio of 27.4 : 36.3 : 36.3 (Figure , supporting information). This ratio is different from the equimolar feed ratio due to the difference in the reactivity ratios (Cf, Table ) amongst the different monomers in the reaction mixture. The two-dimensional Heteronuclear Single Quantum Coherence (HSQC) and Heteronuclear Multiple Bond Correlation (HMBC) spectra of the terpolymer displayed the 1 H- C correlations among monomers confirms the terpolymer formation from all three monomers. The detailed information on the terpolymer synthesis and spectral assignments are presented in the supporting infornation. The synthesized terpolymer exhibits a 𝑇 𝑔 value of -17.5 o C, which is significantly different from pairwise combinations of equimolar amounts of styrene, myrcene, and DBI as well as their homopolymers (cf. supporting information). The above comprehensive data validates the synthesis of a terpolymer comprising styrene, myrcene, and DBI monomers. The objective space presented in Figure to 4c illustrates the trade-off between 𝑇 𝑔 and negative styrene incorporation in the final terpolymer. The observed negative correlation between 𝑇 𝑔 and styrene incorporation supports our initial hypothesis that the addition of styrene would elevate the 𝑇 𝑔 of the final terpolymer due to presence of rigid phenyl side chains. Overall, the optimization process yielded terpolymers with 𝑇 𝑔 ranging from -53.4 °C to 45.9 °C with corresponding styrene incorporation ranging from 0.9 mol% to 84.7 mol%. Figure reports an increasing realized HV across batches, indicating iterative improvements for every subsequent batch of synthesized terpolymers. Consequently, the optimization process resulted in the dense distribution of the 89 terpolymers across the entire 𝑇 𝑔 temperature range and styrene incorporation range. With reference to the input experimental conditions of these 89 terpolymers, we report the complete range of 𝑇 𝑔 and styrene incorporation by which scientists can tailor for desired properties.