We then applied this methodology to the conversion of limonene to paracetamol as our group is interested in converting terpenes into useful products in order to valorize paper waste through a circular economy approach. The first task was to design a set of potential edges that, if correct, would provide more efficient synthesis routes from limonene to paracetamol. Testing all combinatorially-possible transformations in this network would require ranking of more than 26 billion transformations, many of which would be irrelevant for this system. From our previous study we know that the synthesis can be carried out in five steps. Taking the set of molecules involved in the four-and five-step routes allowed us to ensure that any discovered transformation was relevant.