Moreover, it was also observed that downregulating these adhesion GPCRs with siRNA caused a significant reduction in SARS Cov-2 entry and infection and also reduced the infection in cell lines. Therefore, it can be inferred from the study that these adhesion GPCRs play a crucial role in coronavirus infection . Moreover, a study of 246 people revealed a significant association between Covid-19 severity and autoantibodies targeting GPCRs and RASrelated molecules. Higher autoantibody levels were found in those patients with severe or moderate Covid-19 disease as compared to those people with mild symptoms of Covid-19. Chemokine receptor CXCR3 and AGTR1 which is a RAS related molecule were found to be the most potential targets for antibodies associated with Covid-19 according to machine learning classification models constructed in the study . Beyond that, several cardiological as well as neurological issues occur after recovery from the initial phase of Covid-19. These symptoms are similar to those observed after some condition with some specific autoantibodies P a g e 13 | 56 i.e. fAABs. fAABs basically target certain GPCRs and therefore affect the cell responses.