In these atomistic models, transitions such as, e.g., the isomerization of the amide, as well as amide encapsulation/expulsion in/out the cage are typically rare events, which cannot be effectively sampled via classical MD simulation. Recently, it has been demonstrated that the kinetics of rare events can be efficiently reconstructed by means of infrequent WT-MetaD simulations. Provided that the the CV and setup of the WT-MetaD simulations are opportunely chosen, this approach relies on the fact that the real unbiased timescale of an event can be retrieved from the statistics obtained for the biased event, by calculating the transition time distributions.