The Shono oxida on is a paired electrolysis, with both anodic and cathodic reac ons necessary for the forma on of the product. Hydrogen gas is produced in the reac on as the only stoichiometric byproduct. To begin our studies, we selected 1 as a substrate for op miza on and collected cyclic voltammetry (CV) data (Figure ). CV demonstrated that the first oxida on occurs for this substrate at +1.55 V vs Ag/AgNO3, with a second oxida on occurring at +1.83 V. The second oxida on wave lies very close to the overlayed CV of 2. This highlights the challenge in selec ve oxida on of 1 as there is only a 280 mV separa on between star ng material and product. The ini al evalua on of the reac on revealed that if constant current condi ons were applied, at high conversion (>95%) overoxida on to product 4 would cons tute more than 10% of the mass balance and would likely exclude such a reac on from considera on for pharmaceu cal development.