Similarly, Amides, like carbamate, they also have long been used in syntheses because they offer the advantage of particularly good stability to a wide range of conditions. there are several routes for the preparation of amides. In most of this reaction, a carboxylic acid is converted into a more reactive intermediate, e.g. an acyl chloride that is then allowed to react with amine in presence of metal or tertiary amine . Attempts have also been made to prepare amide directly from acid using acid activator such as dialkylphosphochloriate , phosphorous-complex , benzoxazole-sulfur dimer , EDC/HOBT . Amides are directly prepared from alcohol , nitrile , oximes , alkane , alkyne , boric acid and thioamide .