Coarse-grained Molecular Dynamics (CGMD) is a mesoscale modeling technique in which only a subset of a system's degrees of freedom are directly modeled and the remainder are averaged out. The use of a coarser representation offers improved computational efficiency, potentially simpler mechanistic interpretation, and bridges the gap between atomistic and continuum scale modeling. For these reasons, CGMD has been applied extensively in applications involving timescales and lengthscales that are challenging to address atomistically, including protein aggregation and folding , lipid mechanics binding , organic electronic materials , nanoparticles , and metal organic frameworks .