For some of the BACE-1 inhibitors, we had submitted multiple pose predictions. We will be referring to the pose that we ranked first in our submission as the 'top' pose and the pose with the lowest RMSD as the 'best' pose. In Stage 1a, our 'best' pose predictions achieved a mean and median RMSD of 1.60 Å and 1.79 Å, whereas our 'top' pose predictions did not do that much worse, with a mean and median RMSD of 1.87 Å and 1.88 Å . 12 out of 20 structures had an RMSD of < 2 Å , which is generally considered as a successful docking prediction .