Multiple variants have emerged from those initial Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-Cov-2) isolates to the moderate dangerous Omicron variants with increased spreading power. The Omicron variants presumably resulted after selection by resistance to natural infection or to vaccination . Most recent Omicron variants are still under intensive study , but world-wide reports from several laboratories have confirmed an unusually high number of spike (S) mutations (~30) correlating with increased immune-evasion to vaccination, increase spreading rates and tighter S packing . Most of the identified Omicron S mutations changed the SARS-Cov-2 surface sites implicated in recognition of the human ACE receptor , one of the first requirements for viral/human membrane fusion to initiate Omicron infection. Therefore, most recent studies have focused on mutations affecting the human ACE receptor binding , on Omicron surfaces by drug repurposing .