This section crosses back over the Atlantic to consider the NIH National Center for Advancing Translational Sciences (NCATS). This has produced a range of documentation and publications that is of value not just in general terms for ADEV but also for practical guidelines. One resource that has become well appreciated by the research community is their Assay Guidance Manual (AGM). This is a best-practices online resource with the objective to robustify early-stage drug discovery results from HTS assays and focussed screens. Chapters are written by experts and edited by representatives from industry, academia and government.