Following this first observation, we wanted to test if we can detect clusters within TMAP visualizations of more complex physicochemical properties, such as the predicted fraction of helical residues (Figure ) and the hydrophobic moment (Figure ). In both cases, we could not detect large homogenous clusters as was the case for HAC and fraction C. However, the data formed a large number of small local clusters, indicating that the nearest neighbor relationships in the MAP4C feature space can possibly be used to distinguish sequences with high helicity/hydrophobicity opposed to sequences with low helicity/hydrophobicity.