Although automation can be applied to numerous processes in the development of drug formulations, few studies have explored these applications to date. Fan et al. recently employed a liquid handling robot for the automated high-throughput screening of oligonucleotide-loaded LNPs, in a system capable of preparing a 96-well plate filled with formulations in three hours . The methodology was based on solvent-injection, as this process of mixing phases is amenable to liquid handling automation. Furthermore, the 96-well layout allows for high-throughput characterization, by means of a dynamic light scattering plate reader to measure NP size and UV-Vis plate reader to quantify encapsulation efficiency. In this study, formulations screened on the 96-well plate format demonstrated good agreement in terms of size, polydispersity index, and encapsulation efficiency with larger scale microfluidic batch production . This suggests the potential for small-scale automated screening of drug formulations followed by translation and scale-up of production methods. This was further demonstrated in a follow-up study using the same automated high-throughput workflow to identify optimal LNP formulations for gene silencing . Similar high-throughput approaches have also been used to screen and prepare LNPs encapsulating mRNA, as well as to improve methods of quantifying the loading of nucleic acid cargos . Such experiments highlight the utility of liquid handling robots for advancing the design of experimental methods commonly employed for formulation screening. Compared to screening in bulk batches, which is often the case , implementing an automated system to produce NPs could increase throughput while also freeing up more time for researchers to plan experiments and analyze results.