Organoids can expand beyond medicine toward new applications, notably improving material microfabrication. Viewing organoids as living machines, and developmental biology as a manufacturing process, opens new avenues for self-microfabrication of next generation materials, such as spider silk. Self-organized organ production units, which can generate complex biological materials, have the potential to revolutionize the microfabrication industry by enabling the scalable production of large microstructured materials with unique properties. The prospect of achieving lower marginal costs for producing sustainable, high-value-added products creates opportunities for multidisciplinary collaborations among material scientists, tissue engineers, and developmental biologists, paving the way for innovative research trajectories and applications.