Tau protein contains two Mg2+-ATP binding sites: one at aspartate (D13) and the other at glycine (G682). The central portion of the catalytic domain is D13, while the catalytic domain concludes at G682.The tau protein is a dimer, and each subunit possesses pyruvate kinase and phosphatase activity. The aspartate (D13) region is the location of the pyruvate kinase domain of the Tau protein.