Small-angle scattering (SAS) techniques based on X-rays (SAXS) or neutrons (SANS), are established, valuable and widely used tools in structural biology for the characterisation of biomolecules in solution. These methods allow the size, shape, stoichiometry, and dynamics of biomolecules to be assessed under near-physiological conditions, using reasonable concentrations, and without the need of labelling agents . Moreover, the size and the disorder level of the system are not a limitation, enabling the study of diverse biomolecular species . Indeed, SAS techniques can efficiently complement Nuclear Magnetic Resonance (NMR) spectroscopy and Fluorescence Resonance Energy Transfer (FRET) measurements to provide global features when studying multi-domain proteins, intrinsically disordered proteins, and larger complexes . Furthermore, SAS is particularly suitable for the analysis and/or the integration with molecular dynamics (MD) simulations, using either reweighing or restraining techniques , due to the relative simplicity of the forward model to be calculated from an atomic resolution structure.