Developing biosensors to detect SARS-CoV-2 has several advantages over conventional analytical methods, such as rapidity, high selectivity and low-cost of biosensing. Biosensors have been used for detection of a wide range of analytes including viruses . Biosensors for detection of SARS-CoV-2 have been reported by several research groups. The virus detection was achieved by targeting the RNA of SARS-CoV-2 , the antigen and antibodies to SARS-CoV-2 , and the spike and nucleocapsid proteins of the virus . Aptamers can be used as biorecognition elements in biosensors because they can bind analytical targets with very high specificity and affinity. The unique 3D structure and variable conformation make aptamers to be more attractive than antibodies to construct biosensors . In addition, aptamers are stable in a wider range of temperature and pH, and have lower production costs than antibodies .