(3)Tau protein's active function Table demonstrates that the N-terminus and C-terminus of tau protein primarily mediate its DNA protein activity. Replication factor, replication initiation protein, and SF3 helicase activity are also present in the Tau protein. This suggests that the tau protein can bind to the DNA replication origin region with replicon activity and unwind the DNA double helix in the same way as a DNA replication helicase. This activity of the unwinding domain is like the SF3 helicase protein in DNA viruses, which finds the ori domain and unwinds the helix.