To explore further the scope of our method, we next sought to incorporate substituents on to the spiroacetal scaffold. The introduction of even a methyl substituent can drastically affect lipophilicity, solubility, bioavailability and selectivity of bioactive compounds; 64 thus, being able to access methylated and similarly substituted spiroacetal scaffolds would potentially be useful for future hit optimization studies. Moreover, substitution would introduce the issue of diastereoselectivity, which we also wanted to explore.