The Voronoi-PEqS method has been shown to replicate exact (Kirkwood multipolar) solvation results for spherical cavities, and near-exact PCM results for molecular cavities, which justifies our smooth Voronoi construction of the permittivity function ε(r). The latter can be used as a test of the ad hoc HetPCM approach. The HetPCM and Voronoi-PEqS methods afford solvation energies (∆G elst ) within 2 kcal/mol of one another when the nonpolar dielectric constant is ε nonp = 4 or 10, but agreement deteriorates considerably for ε nonp ≤ 2.