First, reaction fingerprint tools used to classify reaction types could be combined with already known reaction patterns to increase the coverage of reaction types already included in the reference. Second, it is likely feasible to improve the voting procedure in cases of dissent between different AAM tools. The cycle descriptor introduced as a means of classifying reaction center topologies, for example, may be useful for this purpose. We observed that shorter alternatives are usually the most chemically plausible choices. This observation is theoretically justified by the observation that fewer reaction steps tend to imply lower energy barriers, thus streamlining the reaction process. This adds credibility to combinatorial AAM mapping approaches that seek reaction centers composed of few cycles, such as study of Mann et al. Nevertheless, there is no guarantee that the true mechanism minimizes descriptor lengths. Moreover, complex mechanisms may form bonds that are broken again in a subsequent steps and thus do not appear at all in the ITS and reaction center graphs.