Our data analysis indicates more than 6,600 and 2,900 journal articles and patent publications, respectively, on the application of CRISPR technology in disease diagnosis from 2004 to 2024 which accounts for 17% and 21% of total journal articles and patent publications, respectively, on CRISPR therapeutics in CAS Content collection (Figure The publication trends on CRISPR technology and its various Cas proteins associated with diagnosis have evolved significantly over the last decade as the diversity of Cas systems has expanded (Figure ). Each Cas protein has unique properties and has been adapted for various applications. Cas9 was the first and most widely studied protein in CRISPR research. Early studies predominantly focused on gene editing, but some initial exploration of Cas9's potential for diagnostics began in 2014 with a steady increase in publications (Figure ). The analysis of CRISPR-based disease diagnostics documents co-occurring with various diseases (Figure ) reflects a growing interest in both infectious and non-infectious diseases. Viral infections in infectious diseases and cancer in non-infectious diseases led the way with the highest number of documents, followed by bacterial, genetic, immune, and fungal diseases (Figure ). Publications on CRISPR-based disease diagnostics co-occurring with cancer show continuous and constant growth since 2014, whereas publications on viral diseases show a sudden spike in 2019 (Figure ).