The atomic level distributions of scores are given in Figure . The total atomic score in a sampled ligand docked pose could go negative, and the total comes from adding the individual contributions modeling the different protein-ligand atom interactions. One example is a repulsed carbon atom (methyl) in a strongly hydrophilic amino acid neighborhood, the non-polar component or the repulsive component of the interactions could be negative. If a total atom score is centered about a negative valued peak score, less than some value such as -1.5, then this means that the atom isn't welcome in that location from the binding mode. In Figure , the range of scores in the distributions is . There aren't any negative valued peaks in this case, but there are some negative atomic scores.