Bioactive molecules such as glucose (G), and related compounds, dopamine (DA), Ascorbic Acid (AA), Uric Acid (UA), and so on are of great interest in human metabolism, nervous system, and as well as renal systems . So that, measuring and controlling the levels of these biomolecules is highly regarded in order to master their linked function in the human health. As it is known that abnormal levels can cause many diseases which generate uncountable death worldwide. So, according to the WHO data's, the number of adults living with diabetes has significantly quadrupled from 1980 to nowadays yielding of 422 million as described by Dong's research team . Indeed, as known there exist two principal type of diabetes. So, type (I) is characterized by the lack of insulin production by pancreatic islet cells, and the type (II) is a result of under activity of insulin produced in the pancreas by the body. However, Diabetes are known as a chronic disease, which can lead to complications and severe symptoms, yielding a significant number of deaths. Other these diseases, like Parkinsonism, chronic kidney disease (CKD) are connected to neurological disorder with evolving layers of complexness. As reported in Kalia's work that parkinson's disease has been defined by the classical motor characteristic of Parkinsonism joint with low bodies and failure of dopaminergic neurons in the substantial nigra. However, it is concluded from Su's research analysis that uric acid-lowering medical care appear to improve kidney outcomes and reduce the risk of cardiovascular events in adults with CKD. So, nowadays there are many diseases connected to the abnormal levels of some biomolecules in our organism or by the large consumption of industrial products. So, due to that, Researchers, engineers, Doctors, professionals, and so fourth are exploring new routes for the design of favorable catalysts for diverse disciplines. Indeed, recently a full descriptions of nickel-based hybrid catalysts were investigated in research work for diverse considered reactions. Also, the same researcher analyzed the performance of Copper-based materials for reduction reactions like (CO2, NO3 -) to high value-added products and these catalysts might be taken as an anode catalyst we believe. Furthermore, Mouratib, R et al showed a development of modified carbon paste electrode with a material that contains high amount of Al-and-Si. This modified electrode was used as active catalyst for water treatment sludge (WTS) for Bis-phenol-A sensing. According to their manuscript, the prepared catalyst delivers superior electrocatalytic activity toward the targeted reaction (oxidation of Bis-phenol-A) which yields a low limit of detection as high as 0.1 µM. In addition, Salhi, O et al fabricated a poly-1.8-Diaminonaphtalene and cysteine modified black carbon electrode (Poly-1.8DAN/Cys/CB) for the determination of nitrite in real samples. So, the designed electrode yields outstanding electrocatalytic activity toward nitrite ions finding. As a result, the prepared (Poly-1.8-DAN/Cys/CB) showed a very low limit of detection as high as 0.25 µM. It is mentioned that this research work highlights a simple preparation method of a polymeric film which might contains considerable amount of both amine and thiol groups for nitrite sensing. Recently, Govindaraj, M et al demonstrated that nowadays, there exist many several categories of non-enzymatic glucose sensor materials. These materials include, composites, non-precious metals and their hydroxides, alloys, oxides, precious metals, and their alloys, carbonbased materials, conducting polymers, metal-organic frameworks (MOFs) and so fourth. Moreover, Naikoo, G.A., et al dedicated a review on the trends in bimetallic nanomaterials and methods for the fourthgeneration glucose sensors (FGGS). So, it shows that bimetallic-based glucose sensors are an up-and-coming evolution in the field of glucose biosensing. Also, those biocompatible, nanocomposites exhibits considerable surface area for sensitive glucose discovery. Moreover, bimetallic nanomaterials have advisable physical phenomenon and sensing performance than the monometallic one. Indeed, bimetallic nanomaterials are used for signals amplification during glucose determination. Although, there exist such candidate nanomaterials, but their prices, the preparation methods, the availability, and as well as the environmental-friendliness must be well issued for best purposes. Therefore, in this research manuscript, we aim to address a brief review on the recent development of novel nanomaterials for both organic compounds detection and oxidation like (glucose, dopamine, so on) by electrochemical methods with the help of active catalysts. It is believed that this research review may guide for new perspectives to design powerful candidate materials for the considered issue. This may overcome many facts that limit the widely use of sensor and Biosensors for both organic and inorganic compounds detections in real samples.