From figure it can be seen that there are some statistically significant differences for the ∆∆Gs calculated with each method. Note that in figure there are no error bars on the xaxis; this is because no errors are reported with the experimental results . These differences in the PTP1B case should not detract from the overall excellent agreement between all where the difference between methods is around 0.5 kcal/mol. Due to the number of differences between methods, highlighted in previous sections, it is not possible to comment on what precisely causes any particular difference here. Despite some differences for individual ∆∆G calculations in MD packages, overall the results are well reproduced which can also be seen from the properties calculated in table where the rank order coefficients suggest a strong correlation between all methods with the lowest Spearman's, Pearson's and Kendall's correlation coefficient between two packages being 0.91(0.04), 0.89(0.06) and 0.74(0.08) respectively.