A visual perspective on convergence to the ωB97M-V/ CBS limit for these systems is presented in Fig. , for two of the ligand-protein complexes. (Corresponding plots for the other two complexes can be found in Fig. , and for M06-2X in Fig. .) In small basis sets, the CPcorrected value of ∆E int is much closer to the CBS limit as compared to the uncorrected interaction energy, which is systematically overbound. CP correction reduces the interaction energy in a systematic way as the CBS limit is approached and although its effect is diminished in larger basis sets, the CP-corrected interaction energies hew more closely to the DFT/CBS limit than do the uncorrected values, with the former being close to convergence already for def2-SVPD. This parallels what we have seen for other systems and suggest that double-ζ interaction energies are completely unreliable in larger systems unless CP correction is employed. Unlike the results in smaller systems, however, here the triple-ζ results cannot be considered to be converged (even in the presence of diffuse functions) unless CP correction is applied, although the fully-augmented def2-TZVPD basis set comes close. Timing data for the 1HSG:indinavir complex (Fig. ) demonstrate that CP-ωB97M-V/def2-SVPD is 6× less expensive than the def2-ma-QZVP that is otherwise needed to reach the CBS limit.