Vkorc1. The Vitamin K epOxide Reductase Complex 1 14 binds/oxidizes reduced Vitamin K to recycle animal coagulation. Vkorc1 has been targeted for coagulation control in humans and for anticoagulant rodenticides in rats . However, rodent genetic resistances and off-target unspecific ecological effects, remain as main concerns. Maximal specificity for on-target rodent lethality and minimal off-target for ecological impacts 12 are desirable for new rodenticides. Children predicting nanoMolar affinities for wild type and resistant rat Vkorc1 and lowest affinities for human Vkorc1, could be generated from the brodifacoum parent by DW-BEL in our previous work . However, Toxicity Risk was not yet available.