Looking forward, we anticipate that these state-of-the-art RT-TDDFT approaches could accelerate PFAS remediation efforts in two immediate ways. First, our predictive calculations demonstrate that electromagnetic/optical fields are a viable and direct approach to degrade PFAS pollutants as opposed to conventional filtration techniques that merely remove PFAS (which still require treatment after filtration). Second, these RT-TDDFT approaches can guide ongoing experimental efforts by rationalizing or high-throughput screening of new photocatalytic materials/surfaces, which have started to garner immense attention for enhanced PFAS degradation. As such, the RT-TDDFT techniques used in this work provide fresh opportunities for exploring excited-state, photo-induced degradation dynamics that are actively being explored in the remediation of PFAS and other environmental contaminants.