Taking into account the need to assess the environmental impact of the new methods of chemical synthesis, we calculated Green Chemistry Metrics (GCM) values for the quinine quaternization (1Br-4Br) and for the anion exchange reaction from bromide to amino acid anion (1Asp-4Asp, 1Ala-4Ala). The results are summarized in Table . Despite the 100% atom economy of the quinine conversion reaction to 1Br-4Br, the need for additional media in the course of purification of the finished salt results in an increase of the E-Factor values ). These values are within the range typical for industrial synthesis of fine chemicals . The lower efficiency of the 4Br synthesis process results in higher E-Factor values compared to the more efficient syntheses of 1Br-3Br compounds. The E-Factors for the aforementioned reactions may be lowered by improving the selectivity of the process to lower the amount of by-products requires to be separated. The anion exchange process is characterized by more favorable GCM values compared to the syntheses of 1Br-4Br. Despite the lower atom economy (82-86%) resulting from the nature of exchange reaction, the total alkalization and neutralization efficiency is almost equal to the theoretical one (>99%), which translates into a reduction in waste generation and lowers the negative environmental impact. This is indicated by E-Factor values ranging from 1.90 to 1.97, more than twice as low as the lower end of the E-Factor range characteristic of fine chemicals synthesis (5-50).