We find that LOMAP designs can achieve a similarly peaked distribution of leverages compared to D-optimal designs. We observe this similarity in the leverage distributions in Pfkfb3, Ptp1b, and Cdk2 ligands where 𝑘 was restricted to the number of edges chosen by LOMAP (Fig. ). Both LOMAP and D-optimal designs favor cycles (Fig. , ). As a consequence, the leverages are balanced so that no subset of transformations exerts undue influence on the predictions for the changes in free energy.