We next aimed to explore further the generality of our developed reaction conditions, applying them to the cross-electrophile coupling of RAEs, derived from a diverse set of carboxylic acids, with various aldehyde-derived sulfonyl hydrazones (Figure ). We envisioned providing streamlined access to cyclic and acyclic β-arylethylamines, thereby presenting a new, intuitive radical disconnection for practitioners in the field. Regarding the scope of the α-amino RAEs, a myriad of medicinally pertinent cyclic structures-encompassing azetidine, piperazine, indoline, and isoquinoline-were successfully coupled, achieving synthetically useful yields in all cases (27-33). Significantly, the methodology enabled the conversion of even challenging tertiary RAEs, facilitating the creation of quaternary centers, albeit with somewhat reduced yields (34-36). Beyond cyclic structures, the protocol also exhibited proficiency with a range of linear amino acids, yielding the corresponding βarylethylamines in moderate to good isolated yields (37-41). An assessment of the sulfonyl hydrazones scope indicated optimal performance with electron-poor groups (see Supplementary Information, section 11). Noteworthily, the metal-free nature of the protocol tolerated halogenated arenes and heterocycles, providing convenient handles for subsequent synthetic elaboration (30, 47, 48, 50-53). A noticeable limitation of the scope was observed: electron-rich sulfonyl hydrazones yielded only traces of the desired product, with a notable reduction of the carboxylic acid. Additionally, under slightly modified reaction conditions (see Supplementary Information, Table ), unactivated aliphatic aldehyde-derived sulfonyl hydrazones acted as effective coupling partners, delivering alkylated secondary amines in synthetically useful yields, and underlining the method's simplicity and versatility (54-58). Reaction conditions: RAE (0.3 mmol, 1 equiv.), Sulfonyl Hydrazone (1 equiv.), Hantzsch ester (1.5 equiv.) and EYNa2 (0.10 equiv.) in 3 mL of CH2Cl2 (0.1 M). For further experimental details see the Supplementary Information.