In this section, the RBFENN will be applied to two RBFE benchmarking congeneric series: TYK2 and TNKS2. Although these test sets are present in the training set (figure ), this is assumed acceptable for this work as the majority of perturbations in RBFE-Space have duplicates in other congeneric series. Leaving the TYK2/TNKS2 perturbations out of the training set would thus remove a large number of perturbations that exist in any congeneric series such as (de-)halogenations and other 1-3 heavy atom perturbations. As there is such large overlap in perturbation-space between congeneric series, the majority of TYK2/TNKS2 perturbation would be present in other series as well and would have to be included in RBFE-Space in such a scheme anyway.