Of relevance to integrated catalysis, compartmentalization has been used to construct efficient tandem organometallic systems that otherwise cannot operate homogeneously. In the following paragraphs, we will highlight some of these examples, and discuss confinement approaches, relevant characterization, necessary requirements, and potential pitfalls. It should be noted that the majority of confined organometallic catalysis focuses on employing macromolecular structures to tune selectivity in a manner unachievable in a homogeneous setting. Additionally, the confinement of such catalysts often results in improved stability and heightened activity over freely diffusing analogues. Though some of these attributes may prove beneficial in an established integrated system, the focus of employing spatial control within integrated catalysis is to spatially separate catalysts while maintaining the activity of the homogeneous counterparts. Furthermore, compartmentalization has been applied to organometallic mediated catalytic chain transfer polymerization, from which insight into the relationship between confinement and polymer modality has been extensively studied. Seminal work in compartmentalizing organometallic catalyst(s) was demonstrated by Raymond, Bergman, Toste, and coworkers by encapsulation in molecular cages to accelerate reaction rates, as well as alter selectivity. Following this work, Weck and coworkers in 2015 employed a micelle support to pair two co-encapsulated catalysts for incompatible catalytic reactions. In this report, the authors spatially localized an alkene functionalized Co-porphyrin and an amine functionalized Rh-TsDPEN (N-tosylated 1,2-diphenyl-1,2-ethylenediamine) catalyst (FIG. ) for tandem alkyne hydration and hydrogenation to an alcohol. First, the micelle support was constructed via a custom triblock copolymer prepared by the cationic ring opening polymerization of various 2-oxazoline derivatives. The first block consisted of a hydrophobic alkyl core that serves to encapsulate the Co-porphyrin moiety. The end block contained an ester moiety, which would later be hydrolyzed to the corresponding carboxylic acid to allow attachment of Rh-TsDPEN via peptide coupling. Further, an alkene side chain middle block was incorporated into the polymer, followed by alkene hydrothiolation to allow subsequent cross linking by UV initiated thiol-ene chemistry with the Co-porphyrin unit. Upon successful preparation of the polymer micelle, the authors moved to functionalizing the two catalysts within the support.