Similar to what was observed for Figure , the prompt interprets the center of the molecule as being the "backbone," and only makes changes to the methyl group on the right-hand side of the molecule. This group was exchanged for amine, methoxy, alcohol, and other similar electron-rich moieties in the case of the EDGs, as expected. For EWGs, a similar trend occurs, but the functional groups are more complex, including carbonyls, carboxylic acids, esters, nitriles, F-containing groups, and sulfonyl groups, all of which are reasonable EWG substitutions.