Methylcyclohexanol, is a neutral molecule whose hydrophobic aliphatic ring can form hydrophobic interactions with the nonpolar interior of the cyclodextrins, and whose hydroxyl group could form hydrogen bonds with the hydroxyls of the primary or secondary face of the hosts or with the substituents added to the cyclodextrin derivatives. However, its affinity is likely limited by the fact that its hydrophobic group is too small to fit snugly into the binding cavity and interact favorably with the entire inner wall of the host at one time. Rekharsky et al. reported binding of this compound to β-CD with ΔG = -19.00 ± 0.07 kJ/mol, and our result is in excellent agreement with this prior measurement.