In an earlier computational study, we identified RSV-604 as a potential SARS-CoV-2 M pro inhibitor using Autodock Vina followed by MD simulation of the lead molecules in the active site of the protein . Although no previous studies have predicted epirubicin to have activity against the SARS-CoV-2 helicase it has been identified as an inhibitor of chromodomain-helicase-DNA-binding protein 1 and HCV helicase . No prior studies have reported activity of fluspirilene against the SARS-CoV-2 helicase, although it has been predicted to have activity against the SARS-CoV-2 nsp9 replicase . Tam et al. reported it to have M pro activity, and the DG of binding calculated by Autodock Vina correlated well with experimental DG of binding from the experimental IC50 values of a range of putative antiviral agents .