There are 4 ligand-protein hydrogen bonds to Mpro in the pose at 70. The ligand atoms that form hydrogen bonds in the 1 st binding mode is found by adding the hydrogen bond contribution to the atom interaction, column 5 in the GOLD output file HBond(atom).S, over all of the output docking files. The cutoff for this binding mode is 66 and there are 1434 with higher total scores. The frequency of hydrogen bonds in these states is: are dimensionless numbers representing the interaction of docked ligand to the protein; the rough correspondence between PLP score differences and energy differences is found heuristically by known calculations and is roughly 6.5 PLP for 1 kCal for various non-covalently bound molecules. The binding energy is important in biochemical terms of ligand in the on-/off-states. In terms of k_D or on-off ligand binding fraction, 1 kCal is commonly referred to be a factor of 10, 10 𝑥 , although this is not a linear or rigorous relation.