DNA's double helix structure and base pairing allow for the encoding of information, which can be converted to various forms under external conditions. The potential of DNA computing for use in biomedical and biological diagnostics has been investigated. While DNA-based logic systems can perform computations, similarly to analog computers, such as cascading, signal storage, feedback, and amplification, they are not yet as powerful as current semiconductor computer technology due to limitations in nucleic acid molecules. However, The application of DNA computation in diagnostics brings forth several benefits, including the ability to integrate biomarker recognition with the analysis and reporting of results, programmable logic for more accurate results, and the ability to interface with traditional biosensing and clinical diagnostics . There are several ways to construct a DNA-based computing device, but most of them rely on DNA as the foundation to create the fundamental logic gates of digital logic, such as AND, OR, and NOT gates. Construction of DNA logic gates could be based on DNAzymes , , strand displacement mechanisms , toehold exchange , chemical reaction networks (CRNs) , enzymes , or algorithmic self-assembly , .