iii. N-AcetylTyrosine with Kinase Domain of Human HER2 The binding scores in the table above range from -7.7 to -5.2. A lower docking score indicates a stronger binding affinity between the ligand and the receptor. Therefore, cavity 4 has the strongest binding affinity, followed by cavities 1, 5, 3, and 2. Cavity 4 is also the smallest cavity, with a volume of 156 cubic angstroms. This suggests that the ligand may be able to form a few very strong interactions with the receptor in this cavity. Cavity 1 is the largest cavity, with a volume of 4502 cubic angstroms. This suggests that the ligand may be able to form many interactions with the receptor in this cavity, but the interactions may not be as strong as those in cavity 4. The docking results in the table above suggest that the ligand has a strong binding affinity to all five cavities of the receptor protein. This is supported by the following evidence: