There is clear applicability for Bayesian model comparison methods to neutron and X-ray reflectometry analysis, given that the analysis typically takes a modeldependent approach. In this work, we build on the work of Campbell et al. by comparing the analytical mod-els outlined therein, using a Bayesian model comparison method. In doing so, we outline a general, robust framework for the comparison of analytical models that can be applied by experimental users as a component of their data analysis workflow or included in analysis software packages. Finally, we discuss the effect that different combinations of isotopic contrasts can have on the application of particular analytical models. This is achieved through the investigation of seven isotopic contrasts of neutron reflectometry data from a 1,2-distearoyl-snglycero-3-phosphatidylcholine (DSPC) monolayer at an air-water interface, previously published by Hollinshead et al. . We plan to apply the methodology outlined herein in future work focusing on the information content available in a given experimental dataset, building on recent work from Treece et al. .