The totality of potential products defined from N BB building blocks and n t transforms as N BB 2 * n t can be seen as a large, triangular, three-dimensional matrix. Even though this matrix is very sparse, it contains for each filled cell (i.e. saved product) a large set of neighbors with R1 being constant and R2 varying, and vice versa. These sets can be seen as SAR series of sorts, which is a built-in feature of the approach. Due to the variety of chemistries presented in our transforms, the diversity within these series however is likely higher than in typical large-scale combinatorial libraries. Detailed diversity analysis of SAVI will therefore be needed to determine how close these compound series are to SAR series typically used in medicinal chemistry. For each accepted SAVI product, we can estimate the average size of the SAR series as follows. Remembering that the duplication across product space is about 15%, i.e. 85% of the products occur only once across all transforms, we can without too much error project all products onto the flattened two-dimensional matrix sized 143,365 x143,365, which has 20.6 billion cells. If all cells were filled in a triangular occupation, each generated molecule would have ½ * 143,365 SAR neighbors within each row, and the same number within each column, i.e. a total of about 143,000 SAR neighbors. A SAR neighbor is defined here as a molecule having the same BB R1 but any other R2, and equivalently for R2. However, we have only about 17% of the (triangular) matrix elements filled with truly generated products. This yields an average of about 24,800 SAR neighbors for each SAVI product.