Future studies could focus on examining the frontier orbitals of the molecules in question, which would provide insight into their chemical reactivity and stability. Performing bonding analysis, such as Natural Bond Orbital (NBO) analysis, could also reveal essential information about the electronic structure and bonding patterns within these molecules. By thoroughly exploring these factors, one can gain a deeper understanding of the reasons behind E min 's accurate predictions. These analyses could serve as an ideal follow-up study to elucidate the strengths and limitations of E min as a synthesizability descriptor.