The synthetic accessibility was computed using the SAscore. Synthetic accessibility is a combination of fragment structures comprising historical knowledge of chemical synthesis and a complexity penalty that considers non-standard structural features like stereocomplexity . The score is scaled to 1 (very easy to synthesize) and 10 (very difficult to synthesize). Those molecules with a SAscore greater than six are considered not synthetically feasible. SAscore was calculated using the implementation available in the RDKit library.