What sets this type of bionanorobot apart is its programmability and intelligent controllability, along with its high versatility due to functional biological components. A DNA platform nanorobot, integrated with other modules such as CRISPR, may be able to explore cellular processes, detect mutations caused by cancers or genetic disorders, interact with molecules, make feedback to external controllers, and deliver medicine within the body. While there have been recent advancements in developing biomedical nanorobots using alternative platforms , , the distinctive features lie in their ability to be programmed and controlled externally, as well as their versatility in utilizing functional biological components. Some of the recent prototypes of this model would be a DNA nanorobot that possesses intelligence and is designed to autonomously prevent blood clotting in human plasma. The nanorobot consists of a cylindrical DNA structure as the main framework, with embedded molecular reaction cascades serving as the computational core. By intelligently detecting the level of thrombin in the immediate surroundings, the nanorobot can initiate anticoagulation on its own when there is an excessive amount of thrombin present. The specific concentration of thrombin that triggers the nanorobot's response can be adjusted as desired to prevent potential side effects caused by an excess of thrombin. This capability allows the nanorobot to be applicable in various medical scenarios for autonomous anticoagulation, providing inspiration for a more effective and safer approach to personalized medicine in the future . While in the delivery of oligonucleotide drugs, the nanorobot should detect the targeted cells and go towards them by movement tools, it may be possible to introduce certain functions or algorithms that, when calculated by the nanorobot, will allow it to attach to or enter the cell (Fig. ) and after affecting the cell and detecting the response, the nanorobot may calculate the reverse function or other algorithms to detach from or exit the cell (Fig. ) to prevent the excess accumulation of the nanorobots in the cells. This bio-nanorobot, equipped with a DNAbased Central Processing Unit (CPU) as its control center and a sophisticated dynamic device complex as its physical structure, serves dual purposes as both a diagnostic and therapeutic tool. It stores individual genome data in its memory to detect gene mutations. Utilizing its computational capabilities, it can distinguish diseased tissue from healthy tissue, offering superior accuracy and safety compared to conventional drug carriers that react passively to system stimuli. Unlike passive carriers, the DNA nanorobot actively engages with molecules or cells, executing operations and effectively delivering the oligo drugs (Fig. ). Integration with biological components like CRISPR/Cas9 enables the editing of problematic genes after entering the nucleus (Fig. ). Through precise DNA cutting and leveraging natural repair processes, it can deactivate or treat cancerous cells rather than simply eliminate them[130], thereby bolstering the body's immune response against cancer. Ongoing exploration of the machine-learning capabilities of DNA computers , [132], along with the utilization of additional components such as enzymatic neural networks[133], holds promise for empowering decision-making abilities within the biorobot. This means that if the biorobot carries nucleic acid drugs, it can adaptively reprogram them using its programmable gate arrays in response to further mutations resulting from genomic instability, adjusting the drugs as needed for treatment. These advancements might also facilitate alterations to the DNA vehicle itself while inside the body, allowing this compact DNA-based "bio-AI" to autonomously reprogram in response to changes in the tumor microenvironment or other bodily incidents. It could continuously monitor the body's health throughout its residency (Fig. ), even years post-treatment, to prevent cancer recurrence.