A major advantage of the MFCC-MBE(2) method compared to other, very general formulations of many-body expansions with overlapping fragments is that it retains the simplicity of the MFCC scheme. In particular, it uses the amino acids as fragments, and it only requires calculations of these fragments and combinations thereof (i.e., fragmentfragment dimers, fragment-cap dimers, and cap-cap dimers), which makes its implementation straightforward. This simplicity will also make the inclusion of higher-order many-body contributions on top of MFCC easily possible.