In summary, novel crosslinkers Rubiq, Rubpy, and oNB provide a route towards the first tricolor visible light-degradable gel system. We have established that these crosslinkers are synthetically accessible with moderate yields and photoresponsive to low-energy light. These species are highly photoactive under visible light irradiation rendering PEG-based hydrogels that rapidly and orthogonally degrade under red (617 nm), green (530 nm) and blue (405 nm) light.