CATHEDRAL workflow highlights up to 41 unique compounds, annotated with at least two indiscriminately MS/MS or NMR dereplication tools, including 7 compounds in Fig. . The outcomes are reported in Tables. S1-S7. The best confidence level annotated structures correspond to those with the same candidates for all annotation tools. They are all classified as flavonoid derivatives and FBMN / SIRIUS jointly annotated features. In addition, 21 among the 27 structures jointly annotated by NAP / SIRIUS correspond to diterpenoids (abietane and derivatives) and triterpenoids. Most features annotated jointly by at least two different tools are [M+H] + (37 among the 50 iterations of annotated compounds). The structure candidates highlighted by NAP / SIRIUS and SIRIUS / CaraMel comparisons also include other ion species and insource modifications, respectively [M+Na] + and [M+K] + adducts or in-source modifications. As a result, the strategy for matching experimental spectral databases appears to prioritize annotating features associated with flavonoid chemical families and [M+H] + adducts over other chemical families and ion species. Moreover, the chemical diversity is more prominent when considering the chemical classes related to annotated compounds from in silico and de novo strategies. Finally, the de novo strategy for mass data annotation allowed the annotation of nine of the 25 structures found by 13 C NMR data annotation. Five compounds among them were neither jointly listed by experimental nor predicted mass spectral database matching.