) is an open-source platform that allows users to design complex workflows for data processing and analysis using a node-based graphical user interface, making it easier to build models and analyze data without requiring extensive code. It can be downloaded for free at . Some compiled workflows require specific nodes contained in extensions that can be downloaded from the install section in KNIME´s main interface. Table summarizes numerous studies that have reported the development of KNIME workflows for diverse medicinal chemistry and computer-aided drug design processes, demonstrating the versatility and utility of this tool. InChiKeys, etc. The third node (c) converts the linear notation into a specific object, which is then used by the subsequent node (d) to perform various chemoinformatic analyses: Calculation of descriptors and molecular fingerprints and identification of substructures like PAINS and molecular scaffolds. Due to this node's different calculations, it will be referred to as an action node. Finally, a writer-type node (e) must be added, so the results can be stored.