Carrageenan (car-) are comprised of linear sulfated polysaccharides family isolated from the species of Rhodophyta . These polysaccharides and their derivatives have been exploited in cosmetics, food, and pharmaceuticals. Other beneficial activity of car-has been further explored in the drug delivery system as a controlled release agent that possess antioxidant properties as well . There are three variants of car-i.e. lambda, kappa, iota, and among them κpossess peculiar range of properties such as biocompatibility, biodegradability, mechanical strength and hydrophilicity exploited in food industry as a stabilizing and thickening agent . Car-films in combination with glycerol and citric acid further ameliorate the anti-microbial activity . While reliable bioassays are needed to recognize a wide range of pharmacological properties present in plants and their corresponding metal complexes. Chromium (Cr 3+ ) is a toxic metal and carcinogenic but its complexation with few ligands proves them to be a potential therapeutic agent. Cr 3+ complexes with amino acid derivatives showed antimicrobial activity against different bacterial species. Antibiotics with ceftriaxone with metal complexes showed good antimicrobial properties. The complex of metals with 4-hydroxypyridine and azide ion Zn 2+ complex with tridentate ligand showed low antibacterial but high antifungal properties. The movement of Cr 3+ in living organisms depends considerably on the complexation of the metal center by chelating nitrogen donor ligands. Cr 3+ cysteine and hydrazide complexes, on the other hand, have noticeable antibacterial and antifungal activities. Sulfonamides, Sulfanilamide derivatives and cephapirin with Cr 3+ complexes showed good antimicrobial properties. Monoamine oxidase-B inhibition by Cr 3+ triethanolamine complexes leads to the prevention of some neurodegenerative diseases. The activities of compounds obtained from plants and their metal complexes can be detected by the same conventional methods based on the same principle and are not equally efficient and sensitive. It is clear that biological evaluation, in general, can be carried out much more proficiently on water-soluble, nice crystalline complexes than on mixtures like plant exudate . However, the antibacterial activities of Cr 3+ with κ, to the best of our knowledge, have not been reported yet. Previously, we had studied the preparation and antimicrobial activity of nicotine and its Zn 2+ complex. However, minimum inhibitory concentration (MIC) was the basis for the evaluation of the antibacterial activity. In this study, the complexed κin-vitro activity was evaluated against different types of pathogenic gram-negative and gram-positive bacteria.