Beyond physical validity, we wanted to understand how closely the generated docking poses resemble the protein-ligand interaction patterns observed in measured structural data. To this end, we compiled a comprehensive set of 2501 protein-ligand complexes for the 43 targets of interest from the PDB (see Methods for details and Figure for the number of protein-ligand complexes collected for each target). We then generated the PLIFs for all these measured protein-ligand complexes and all protein-ligand complexes generated with docking (see Methods for details). This procedure enabled us to compare the PLIFs derived from measured and generated protein-ligand complexes.