Yet, being able to produce the specific outcome of an experiment is of paramount importance, since factors such as particle size and morphology have an obvious and direct effect on the properties of a synthesized product as well as on the interactions and behavior in potential applications. Employing manual batch mode or continuous flow self-assembly procedures to explore such effects, can lead to less reliable and inconsistent data due to inevitable human errors and batch-to-batch variations. In addition, such approaches demand a significant amount of time to conduct a comprehensive study. Hence, to study such a complex parameter space, highthroughput experimentation is required. As an enhancement to continuous flow technology, inline or online analysis tools can be integrated to the nanoaggregate synthesis flow stream, for real time monitoring of self-assembly processes while significantly reducing potential errors associated with manual or offline analysis, such as human errors in sampling and chemical alterations that may occur in between synthesis and analysis. Further, automation and digitalization of the entire workflow brings enormous potential for the system to perform high-throughput experimentation with automated synthesis followed by automated analysis. There, the reaction setup is pre-programmed to screen a wide variety of reaction conditions with excellent precision, superior time efficiency, enhanced reliability, effective big data handling and also freeing the researchers from monotonous work. We specialize in online monitoring of polymer reactions in continuous flow, and uses spectroscopic and chromatographic methods such as NMR. SEC, and FT-IR for polymerization screening. Such apparatuses constitute chemical robots in some sense, and allow for fast and user independent screening of conditions, since a high level of automation removes human bias from the synthesis outcome. For nanoaggregate formation monitoring, other analytical sensors are required. Warren and team used in situ laboratory small angle x-ray scattering (SAXS) to monitor the progress in size and morphology of nanoparticles during flow-PISA reactions. Furthermore, microfluidic systems have been used for high-throughput synthesis of nanomaterials using parallel flow focusing systems followed by offline analysis using dynamic light scattering (DLS) and/or microscopy techniques. Some studies have been carried out where microfluidic systems were coupled to contact-free fibre-optic system for the inline characterization of micelles and dispersion solutions. In here, we demonstrate the use of a conventional DLS instrument (Litesizer, Anton Paar) for automated high-throughput screening of block copolymer nanoaggregate formation with enhanced precision. We put emphasis on simplicity in order to allow other researchers to follow our approach. To reach this aim, we modified the DLS instrument to allow for continuous on-demand screening in stop flow experiments, as shown in Figure .