Another example of Ru3 being favoured for the discussed transformation is mRCM leading to Civetone (13)-a naturally occurring animal musk isolated from the glands located near the rectum of the African civet (Civettictis civetta) and the large Indian civet (Viverra zibetha). We were pleased to see that with a loading as low as 1.0-0.5 mol% the new catalyst gave macrocyclic ketone (Z)-13 in 84-76% isolated yield with perfect stereoselectivity. For comparison, the benchmark system, Ru2, under the same conditions (110 °C, 0. Tests under "classical" conditions. Being surprised of such high Z-selectivity levels exhibited by Ru3 that were preserved even at as high temperature as 110-150 °C during reactive distillation, we attempted a separate set of testes to verify applicability of Ru3 in reactions other than hightemperature mRCM. First, three model cross-metathesis (CM) reactions were attempted (Scheme 4A). These transformations were conducted in neat, while one of the products (3-hexene, 15) was removed under reduced pressure (Scheme 4A). Under these conditions the internal alkenes: (Z)-3hexen-1-ol, (Z)-6-nonen-1-ol, and (Z)-6-nonenal (14, 17 and 21) were "dimerised" to yield valuable Z-configured functionalised products 16, 18 and 22 highly selectively (96:4 to 99:1 Z/E). Interestingly, one of the products-the bis(aldehyde) 22-was found to possess a very intense musky fruity scent. These reactions were easy to scale-up (up to 5 grams) and required only small amount of the catalyst (0.5 to 0.01 mol%) to proceed. It was also possible to conduct two different CM reactions sequentially one-pot, where the same portion of Ru3 (0.5 mol%) first "dimerised" substrate 14 then, in presence of (Z)-1,4-diacetoxy-2-butene ( ) promoted a CM reaction leading to bifunctional product 20 in 52% yield in two steps and with high selectivity (Z/E = 98:2, Scheme 4A).