We further considered cavity detuning and found that the effective rate constants can be substantially increased with large positive detuning which also nearly eliminates the suppressing effects of the dark states. Encouragingly, this enhancement can be several orders of magnitude larger than the rate constant outside the cavity even when λ D and Γ are large. The cavity detuning also significantly reduces the magnitude of the population transfer from UP to the dark states, due to the enlarged energy gap and phonon bottleneck effect. These results demonstrate that significant cavity enhancement may be achievable for uphill ET-like reactions by CW driving to the UP in a cavity that has been positively detuned to optimize the driving force from the UP to the acceptor states and avoid dark state transfer.