The MEME was used to compare the UniProt database proteins GAP, GEF, and GDI to the Monkeypox viral protein F13. According to Table , the protein F13 of the Monkeypox virus contains the Ras-GEF, Rho-GAP, Arf-GAP, and PH domains but not the GDI-related domains. The Ras-GEF of Monkeypox virus protein F13 contains seven motifs A-G that are involved in the process of membrane fusion. There are two motifs within the Rho-GAP domain. They are located at the C-termini of F13, respectively, indicating that Rho-GAP is involved in the process of membrane fusion. In addition, the F13 protein contains Arf-GAP A and PH A in its C-terminal region. This indicates that Arf-GAP A and PH A are involved in the process of membrane fusion.