. Other computational programs To identify and predict seeSAR leads used for the initial parent definition, the seeSAR vs.10 package () was used as described before . The DataWarrior (Osiris, vs5.5.0.Idorsia Ph.Ltd, ) and MolSoft (ICM Molbrowser vs3.9Win64bit, ) were used for docking and manipulating the *.sdf files, as described before