The quality of the (R)-2-(methoxymethyl)pyrrolidine 11 is also critical. This chiral amine is commercially available from numerous vendors. Reproducible results could not be achieved with different sources of the amine. When comparing good batches of the chiral amine 11 to others that offered an inferior outcome during the BA reaction, no major differences were detected in the Nuclear Magnetic Resonance (NMR) and Headspace Gas Chromatography (GCHS) purity profiles. The chiral purities were also assessed and were > 99.5 % for both cases. The presence of undetected inorganic salts in the purchased amine 11 was likely to be the main cause of this unexpected behavior.