Vesicles have many applications from microreactors and sensors , to drug delivery vectors and models for cell membrane research. Lipids and amphiphilic block copolymers are common materials for fabrication of synthetic or model membrane vesicles in the form of liposomes and polymersomes, respectively. More recently, there has been significant interest in hybrid vesicles for technological applications that combine advantageous material properties from blended lipid and block copolymer components. Inclusion of membrane proteins within the vesicle membrane opens a range of potential applications, from carriers and bioreactors for drug delivery to sensors and artificial cells. Classically, membrane proteins have been reconstituted into liposomes because their membranes most closely resemble their native biomembrane environment. However, phospholipid membranes are known to be chemically and structurally labile. For instance, the oxidation of the double bonds of the fatty acid chains in an aerobic environment decreases membrane stability over time, resulting in leakage of contents by the formation of transitory pores and lipid aggregation.