Our analysis of biocatalysts shows that there is considerable interest in using biocatalysts as a sustainable way of catalyzing various reactions. The consistent increase in the number of publications shows growing interest in this area. The combination of biocatalysts and metal catalysts is also an emerging approach to achieve the sustainability of valuable molecule production. In addition to the highly prevalent enzymes, organometallic substances which mimic enzymes, and other bioderived molecules are also studied as biocatalysts. Biocatalysts have wide variety of applications such as organic synthesis, fuel cells, and sensors.