Raman mapping can be a useful technique in studies of semi-solid lipid formulations. Sacré et. al. characterized a semi-solid self emulsifyig drug delivery system (SEDDS) formulation using Raman mapping in relation to its particle size and distribution . Our research group has shown that Raman mapping is a powerful tool to evaluate the miscibility between lipid excipients and between excipients and API . In the last paper, the joint information of Raman and Near Infrared were used in a multiblock approach to fully characterize structural changes of the drug and excipients during stability studies.