The AP-FP connection is present most frequently in 61.5% of the analyzed ligands, closely followed by the AP-SE and the AP-GA connections with 58.8% and 36.0%, respectively (see Figure .A). This agrees with the finding that subpocket pools AP, FP, SE, and GA contain the most fragments in descending order (Figure .B). FP-GA and FP-SE connections also occur in more than 7% of the ligands each (see Figure .B and C). Generally, the back pockets B1 and B2 are covered less often in the fragment set and they can only be reached through GA. Thus, the GA-B1 or GA-B2 connections appear only in 3.7% and 3.3% of the cases, respectively, while a GA-B1 connection happens slightly more often (see Figure .D). B1-B2 connections are present in only 10 ligands (0,4%, see Figure .E).