Figure shows the reaction kinetics of compounds exceeding femto-molar concentrations in CRN-E that included all compounds and reactions included in Table . Typical intermediates of ethene ozonolysis (i.e., the ozonide, α-hydroxymethyl hydroperoxide, methylium peroxolate) are formed continuously until they decay as ozone is consumed completely (between 1 to 100 seconds). Formaldehyde and α-hydroxymethyl hydroperoxide are the final products of this reaction and they form in the correct equimolar yields. This accurate reproduction of experimental findings 37 was obtained even though reaction rate constants, such as those for the decay of ozone (k QC O 3 in Figure ), deviate orders of magnitude from measured rate constants. Our data thus confirms the error cancellation in transition state energy calculations invoked above.