For principles such as Elenchus and Hypothesis Elimination, the follow-ups challenge consistency and identify counterexamples. For instance, "If this hypothesis is correct, what else must also be true?" helps identify logical dependencies, while "What would we expect to observe if this hypothesis were false?" ensures that alternative explanations are rigorously considered. These follow-ups reflect the iterative questioning process inherent in chemistry research, such as validating a proposed catalytic mechanism or eliminating pathways that do not match observed kinetics.