The LoS concept was next used to determine the vdW radii for the main group elements from the structural data in the Cambridge Structural Database (CSD). We processed 224 001 unique CSD entries, from which more than 40 000 000 intermolecular LoS contacts were obtained and analyzed. An iterative procedure was employed, in which at the 0 th iteration, the LoS was defined with Bondi's RvdW. The LoS contact distance distributions were used to determine Dmax values for all possible A•••B atom pair contacts, while the Dmax values were used to compute the vdW radii, RvdW, for all elements in the dataset by means of least-squares minimization of the function: