Patients' enrolment and standard diagnosis. All the patients involved in the study gave written informed consent as approved by the ethical committee of IRCCS Ospedale San Raffaele and in accordance with the Helsinki guidelines. All the patients have been evaluated through the standard diagnostic workflow according to the most recent WHO guidelines and including morphological, immunophenotypical, cytogenetic, and molecular genetic evaluations. To better focus on morphological features, all the samples were also classified using the French-American-British (FAB) classification . Table reports the list of patients and detailed diagnostic data. In summary, six AML subtypes (i.e., AML M0, M1, M2, M3, M5a, M6) and three ALL subtypes (ALL B Ph-, ALL B Ph+, ALL T) were investigated using samples from 19 patients, each diagnosed with a distinct subtype. Representative stained cells reported in this study were stained using MayGrünwald-Giemsa (MGG) stain (Hemacolor-Merck, Germany). Part of the patients included in this study (see Table ) were already investigated with other strategies in a previous study .