For the LANaPDB database, the NP-likeness scores are around ten (Fig. ), which means that the compounds are labeled as NP-like. The N3PL scores of the COCONUT compounds are also around ten, consequently, these compounds are labeled as NP-like. Nonetheless, in COCONUT the distribution of the NP-likeness scores is extended to the negative values to the LANaPDB distribution. The compounds with NP-likeness scores extended more to the left can be considered as less NP-like. The presence of less NPlike compounds in COCONUT is consistent with the NP-likeness calculator results, which identified compounds containing predominantly structural fragments found in small molecule drugs (Fig. ).