Given the uncertainty of 0.45 kcal/mol for the solvation free energy, the resulting error in log P is 0.47 log P units. The LF-QC dataset consists of 8,891 molecules (see Table ). The LF-QC set is not publicly available due to licensing restrictions. However, the log P tol/w values for each molecule in the LF-QC can be generated by applying the described approach to the provided SMILES strings, which are available in the supporting information as a CSV file.