We have demonstrated that "easy to calculate" and "easy to understand" descriptors may be applicable to described complex reactions, equaling, and even challenging known methods based on fingerprints or neuronal network type featurization. In addition, we believe these TDs to be conceptually easier to understand by even the average synthetic chemist. This does not exclude the necessity to eventually combine some of these methods, but the performance with the minimalistic input has already proven useful in practical laboratory settings. About the authors * = author for whom correspondence should be addressed to Fernando F. Huerta*, fernando.huerta@inoutscience.com, ORCID -0000-0002-6686-8895