and transmission electron microscopy (TEM), respectively. Two types of experiments were carried out employing two major Ab isoforms, i.e., Ab42 and Ab40: The impact of 1-6 on the aggregation of metal-free Ab40 and metal-Ab40 was similar to that observed with metal-free and metal-added Ab42. As illustrated in Figs. 4c and S5a, under metalfree conditions, the signal intensity of the bands from ca. 7-20 kDa assigned to smaller oligomeric Ab40 species was reduced by 4 and 6, while 5 increased the band intensity associated with the species larger than ca. 7 kDa. When 3-6 were treated to Cu(II)-Ab40 and Zn(II)-Ab40, the resultant Ab species indicated the diverse MW distribution in the range of ca. 7-240 kDa to different extents.