The so-defined SE can range between 0 (all compounds are in a single class) to log2n (all compounds are uniformly distributed across the different classes building blocks with pre-validated reactivity using well-established parallel chemistry reactions . Hence, most compounds in the library are made using a small number of reactions (such as amide coupling, click reactions, etc.) by combining a variety of available building blocks . In agreement with previous research, this leads to superior scaffold diversity .