NGTs normalizing flow policy enriches diverse scaffolds. Chemical diversity is critical to hedge against false positives in virtual screens, and throughout early discovery to help overcome liabilities in pharmacokinetics. We evaluated how enforcing chemical diversity, which reports on balancing exploration and exploitation, affected enrichment. We clustered the compounds generated by each method using the Taylor-Butina method (Methods). For both targets, NGT compound clusters outnumbered HE compound clusters on average 10-fold at a Tanimoto similarity threshold of T c = 0.35 (Table ), suggesting that NGT explores chemical space more broadly than HE. Moreover, by design, when we controlled for chemical diversity, NGT maintained significant enrichment (EF MEL The starkly reduced enrichment combined with a lower number of clusters supports the observation that HE adopts a greedier approach in exploration of chemical space, concentrating on specific chemotypes when growing compounds.