The 1 J CC coupling can clearly be observed in the uniformly sampled HMQC spectrum (Fig. , blue), while decoupled singlets are observed in both the NUWS-NUS decoupled spectrum (Fig. , red) and the CT-HSQC (Fig. ). The quality of the reconstruction is high, and examination of one-dimensional cross-sections (Fig. ) again shows that effective decoupling has been achieved, resulting in significantly more intense singlet resonances. In contrast to the CT-HSQC, the natural line width of signals is retained, i.e. FIDs decay as e -Rt rather than being scaled by the amplitude e -2RT , where 2T = 53.2 ms is the duration of the constant time period. As a result, resonances are not only more intense but also more uniform using the NUWS-NUS decoupling approach, in contrast to the CT-HSQC for which fast-relaxing spins can be hard to detect.