The analysis workflow used for analyzing the calculations is available in 90. The statistics in this workflow were calculated using Arsenic, which is a package implementing best practices for consistently calculating statistics and reporting results from binding free energy calculations. The Parsley results were compared to previously published results using the GAFF2.1, 26 CGenFF3.0.1 and OPLS3e force fields. The former GAFF2.1 and CGenFF results were calculated with the same pmx worklow, and the OPLS3e results were calculated with Schrödinger FEP+. More detailed discussion of the workflow, the employed parameters and the analysis can be found in the Supporting Information. Full details of this study will be reported in a forthcoming publication, and a preliminary report can be found in 92.