Important numerical aspects of partial charge assignment could potentially be impacted by the computing environment used for the calculations, so we examine the impact of compute hardware on partial charge variation. We assess the e ect of hardware on individual partial charge generation by assigning charges using an M1 Mac and cross-comparing with results on an Intel processor. For each of our 6 molecules (Section 2.6.1), we generated and stored 50 conformers of each molecule. We charged each conformer on an Intel processor and again on an M1 Mac processor. Thus, for any given molecule, we obtain two sets of partial charges generated from the exact same conformers. Given two partial charge sets generated from conf ormer1, partialcharges1 mac generated on an M1 Mac and partialcharges1 intel generated on an Intel processor, we find the maximal di erence in partial charge seen at an atom. If hardware has no e ect on partial charge generation, we expect each of these methods to produce the exact same or very similar partial charge sets given the same input conformer and the same charge assignment method.