EnzymeML has been designed to support data acquisition, data analysis, and sharing of data by providing a standardised exchange format for enzymatic data (Fig. ). EnzymeML is written in eXtensible Markup Language (XML) and comprises the most relevant data and metadata from measurement and modelling. Given the ubiquity of XML, vast amounts of software are available that read, write, manipulate, and process XML documents. More importantly, XML allows for the specification of a machine-actable schema which ensures interoperability. The central core of EnzymeML is the Systems Biology Markup Language (SBML), an established data format in systems biology for sharing, evaluating, and developing models of biochemical reaction networks . Interoperability with existing software tools and databases is achieved by applying a common terminology and vocabulary that allow the integration of data from various sources for subsequent processing, because many of the concepts supported by SBML -educts, products, reactions, modifiers, reaction rates -are common to enzymology and biocatalysis. However, EnzymeML goes beyond SBML, because it serves to describe the effect of enzyme sequence and reaction medium to an enzymatic reaction.