Treatment of the methanolic extract with solid mixHC [8]-APS resulted in complete removal of ClO 4 -in contrast to non-modified APS, which removed ca. 15% ClO 4 -(Figure , Table , Figure ). Extraction of sulfate occurred with similar efficiency (ca. 85-97%) using both APS and mixHC [8]-APS materials, demonstrating that mixHC [8] is not the main contributor responsible for the capture of SO 4 2 ˉ. The absence of mixHC [8] affinity toward sulfate was additionally confirmed by an ITC experiment (Table , Figures and).