The catalytic oxidation of TDMQ20 was performed using a biomimetic system. To better understand the oxidation of TDMQ20 we recorded the electrochemical response over a wide anodic range (from +0.2 V up to +1.5V, Figure ). The experiments were performed in a phosphate buffer of pH 7.4 to reflect conditions in the human body. In the voltammogram, two consecutive oxidation processes, both irreversible, were observed: a well-defined peak at +0.71 V and a broad and ill-defined oxidative wave over the +0.8 -+1.1 V range (Figure ). Scanning at a faster scan rate did not improve the reversibility of these redox processes. which suggests that the TDMQ20 oxidation process at different pH may lead to various oxidation products. Based on the oxidation potentials of TDMQ20, it can be speculated that this drug candidate is stable in the brain (where strong oxidants are not present). However, it can be oxidised in the liver through cytochrome P450. In order to test whether the first anodic process can be reversible, we have registered cyclic curves in a shorter potential range (from +0.2 V up to +1 V) at all pH values (Figure ). When CV was registered in the shorter potential window only one irreversible oxidation peak (except for pH 5.0 and 6.0) was detected. Scanning at a faster scan rate, as previously, did not improve the reversibility of the redox processes. SWV measurements also indicate that this process is not electrochemically reversible. In SWV the current is sampled in both positive and negative potential pulses, allowing us to obtain information from both oxidation and reduction processes almost simultaneously.