In contrast, the green data points in the SAS maps represent pairs of compounds in region IV, corresponding to compounds with similar activity profiles but very different chemical structures. Examples of these pairs of compounds present in region IV of all SAS maps for all the fingerprints are linoleic acid with reported activity vs. DNMT1, DNMT3a, and DNMT3b and oleic acid with reported activity vs. KDM4; their main sources are avocado, nuts, vegetable oils, and seeds. Another pair of compounds with very similar chemical structure but very different epigenetic activity profile (Figure ) is butein with reported activity vs. HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7, HDAC8, HDAC9, HDAC10 and HDAC 11 vs. isoliquiritigenin with reported activity vs. DNMT1 and BET/BRD4 in which their main sources are soybeans, peanuts, strawberries, and raspberries. It is important to emphasize that the pairwise epigenetic activity comparisons of the compounds of this work are based on the data published in the literature. For this reason, it is better to call them "pseudo activity cliffs" or pro-activity cliffs instead of activity cliffs to the compounds in region IV. This is because some pairs of compounds may have very similar activity profiles but have not been fully tested yet. Examples of these compounds are apigenin and luteolin vs. chrysin. With current data reported in the literature, it is concluded that apigenin and luteolin are compounds that have similar structures with the same activity profile with reported activity vs. HDAC1 and HDAC3, but both compounds are pseudo activity cliffs vs. chrysin, which have activity reported vs.