Two critical considerations when performing slug flow chemistry is the timing and profile of the slug. Knowing to a high degree of accuracy where a reaction slug is within a fluidic system that is likely 10 or more times the volume of the reaction slug is crucial to enable effective collection of the product solution. This becomes even more apparent when two reactant slugs need to meet at a t-mixer. For a complete reaction, both slugs need to begin and end with perfect synchronicity (Figure ) -where the two slugs do not overlap one reagent does not see the other, meaning no reaction can occur (Figure ).