In case (iii) (E AA =E BB =-2, and E AB =0; seeded with an equimolar mixture of A6B0 and A0B6 fibers), the replication of A6B0 and A0B6 on fibers of their own kind occurred with error rates that were approximately half of those in the control without fiber binding (0.27 vs 0.53; Figure ). The error rates of all the other hexamers, except A3B3, were also the same range, but they did not benefit from precursors surface binding, because the building block composition of the surface bound precursors did not match that of the replicating molecules. This effect was most pronounced for A3B3 causing its replication to exhibit a much higher error rate (0.58) in the presence of surface binding, than in its absence (0.17).