Despite the importance of the knowledge regarding the potential relationship between RNA modification and the risk of COVID-19, to our knowledge, no studies on the effects of RNA modifications on the activity of SC2RC have been carried out. One possible reason may be the lack of information regarding the chemical identity and locations of the modifications on the genome. A typical path of research would be first to identify a modification and then to investigate the biological implications of the modification. However, we believe that this typical path may not need to be followed in all scenarios. One reason is that identification of RNA modifications in general is still technically challenging. Recent studies in the area provides some information about modifications on the SARS-CoV-2 genome, but the chemical identities of many modifications are unclear. In addition, compared to the identification of modifications in scenarios such as tRNA and rRNA modifications, identification of modifications on viral genome is more challenging. The reason is that viral RNA modifications are most likely far more dynamic. They are more likely to be different from one person to another, from one viral particle to another, and from one time to another. Even more challenging is that the modifications that can stop viral growth, which are most important to know, cannot be detected using any methods because virus particles carrying such RNA modifications would not be able to multiply, and thus have low abundance or do not exist at all. For these reasons, we believe that it is important to study the effects of potential RNA modifications on the catalytic activity of SC2RC before they are fully characterized, and this is especially true in the cases of modifications that cannot be detected in the SARS-CoV-2 genome.