To gain deeper insights into the influence of the environmental reaction conditions in the synthesis of COF-300 using the micellar approach, we conducted additional investigations to examine the effects of a modulator. As indicated above, modulators are commonly employed during the synthesis of COFs to improve crystallinity, reduce defect density, and facilitate the formation of larger single crystals. To explore the impact of a modulator in our catanionic micellar mixture, we introduced aniline into the reaction media. Aniline is a well-known modulator in COF-300 synthesis; however, its solubility in the micellar mixture was found to be limited at a catalyst concentration below 0.3 м. Therefore, to ensure the preparation of a homogeneous micellar solution, we increased the catalyst concentration to 0.75 м (see the SI for further details of the synthesis). Upon mixing the micellar media containing the COF-300 precursors, aniline, and acetic acid, a distinct color change was also observed in the reaction media. The previously colorless solutions transformed into a yellowish colloidal dispersion.