Various natural and synthetic polymers exhibit the capability to either physically adsorb or covalently bind to gold nanoparticles, depending on their molecular structure and functional groups. The polymers used in this work share a common backbone of polydimethylacrylamide (poly-DMA) which carries residues of propyl silane and polyethyleneoxide azide (see Figure ). The functional group responsible for forming covalent bonds with the silica layer coating the gold surface is the organosilane. We As a further confirmation, TEM analysis was performed on 40 nm SiGNPs (Figure ).