To further display the range of reaction outcomes of the 366 precursor combinations, a Sankey diagram was used (Figure ). In total, 54 precursor combinations (15%) resulted in the clean formation of a single cage topology, the most desired outcome (matching B15, Figure ). The largest proportion of outcomes (23%, 83 precursor combinations) resulted in the formation of a single topology, but alongside insoluble precipitate or incomplete conversion (including I17 and D3, Figure , respectively). Overall, the distribution of outcomes that resulted in a mixture was considerably less than formation of a single cage topology (clean or not), indicating that there is typically a thermodynamic energetically favoured topology that a DCC system will form. Of the HT screen, 19 (5%) resulted in the clean formation of a mixture of topologies (similar to G30, Figure ), and 22 (6%) resulted in the formation of a mixture of topologies with insoluble precipitate or incomplete conversion (mirroring I23 and N29, Figure , respectively). The highest proportion of outcomes, 88 combinations (24%), was where no cage topology was identified (analogous to A8, Figure ) -this includes precursor combinations where both species type and conversion checks may have been passed, but none of the screened cage assemblies were identified in the mass spectra.