This kinetic model demonstrated that homochiral dimers are active catalysts and showed how a small initial chiral bias in the product evolves into increased selection for the major enantiomer. Enantioenrichment occurs as a 1:1 ratio of enantiomeric monomer products is siphoned off into inactive heterochiral species. The fact that the heterochiral dimer is inactive as a catalyst (khetero = 0) provides the "mutual antagonism" inhibition mechanism required by the Frank model. Fitting experimental kinetic profiles to this dimer kinetic model successfully predicted the temporal evolution of ee. Critically, the evolution of ee could be predicted solely from the autocatalytic rate profiles for the reaction carried out under a variety of conditions, including different initial ee values for the autocatalyst, as shown in Figure . It is also important to emphasize that independent validation of the model parameters was obtained under conditions separate from those used to determine the kinetic parameters, which is an essential validation of any kinetic model. . The kinetic model allows prediction of the temporal amplification of ee, which is independently validated by experimental sampling and HPLC analysis (right).