In this work, we introduce a new method to define the Dmax and, accordingly, to compute Dmax-based vdW radii (Rmax) for almost any intermolecular interaction directly from diverse structural datasets. The key idea is to eliminate the background from randomly distributed contacts using the Line-of-Sight concept. It considers the atoms are interacting only when they "see" each other (Figure ) because no other atom in the structure intrudes between them or, in other words, shields them from one other. This concept allows one to redetermine vdW parameters from the bulk structural data and provide an opportunity to find atom-type specific Dmax-based vdW radii for elements in different chemical environments with clear physical meaning. It should be noted, that intermolecular interactions cannot be efficiently reduced to atom-atom interactions and analyzed in great details using energy decomposition schemes. Even though, our approach is in fact a statistical way to approximate the potential energy surfaces, which is independent of the interpretation of the results in terms of atom-atom interactions. We argue that Rmax can be used to improve accuracy of computational approaches directly or indirectly involving consideration of the size of molecules. It will be useful for the analysis of intermolecular interactions in combination with quantum chemistry methods.