The physicochemical environment of aqueous microdroplets is distinct from bulk water, which can be exploited to accelerate reactions or even enable otherwise unfeasible transformations. Recent examples of microdroplet-catalyzed transformations include the acceleration of the Menshutkin, Diels-Alder, , and Aza-Michael reactions, as well as CO 2 reduction to formic acid. Deciphering the factors that are responsible for the intriguing catalytic effect observed is a nontrivial task, in part due to the transient nature of microdroplets and because of their fairly small reaction volumes. At the same time, the size of microdroplets makes it unfeasible to simulate their full complexity in silico. Nevertheless, several hypotheses have been put forward over the years, ranging from partial solvation and solvent ordering, pH gradients, to the influence of electric fields. For instance, in a recent study, Song et al. argued that for the Aza-Michael addition reaction, enhanced acidity is the main accelerating factor, whereas the effect of a microdroplet's interfacial electric field is marginal at best. Gong and co-workers on the other hand argued that neither electric fields nor partial solvation are responsible for Diels-Alder reaction acceleration, but rather the confinement caused by microdroplet shrinking. Based on these conflicting findings, it appears that the catalytic mechanism seems to depend on the type of studied system, which implies that the effects exerted by the microdroplet environment should be examined in a case-by-case manner.