Inductively coupled plasma mass spectrometry (ICP-MS) experiments had shown earlier that complexes M and N (Figure ) specifically target the mitochondrion in A2780 ovarian cancer cells . Noteworthy, TEM (transmission electron microscopy) studies of different protozoan parasites (Toxoplasma gondii, Neospora caninum, Trypanosoma brucei) treated with trithiolato dinuclear ruthenium(II)-arene complexes revealed alterations in the mitochondrial ultrastructure pointing out this organelle as potential target .