The natural origin of the material, while contributing to its environmental friendliness, does not inherently guarantee fast degradation. The rate of degradation is intricately linked to various factors such as chemical structure of the material, number and type of functional groups as well as its hydrophilicity . presented degradation profile of a various macromonomers based on fatty acid derivative comprising ester, anhydride and urethane groups. These served for creating photocurable networks featuring diverse architectures of telechelic macromers, consisting of long chain derivatives of fatty acids, primarily linoleic acid, with dihydroxy, dicarboxy or diamino functionalities . These polymer networks were subjected to hydrolytic and enzymatic degradation studies. The highest hydrolytic degradation ratio at 37 °C was observed for the polymers containing anhydride bonds. However, since the primary ingredient is hydrophobic dilinoleic ester, the mass loss of most of the networks was low, for example, the mass of polyester-urethane network decreased only by 2 % after 7 weeks of hydrolytic degradation. An acceleration of mass loss was observed in the presence of the enzyme (lipase from Pseudomonas cepacia), where after 3 weeks, the mass losses was approaching 4% .These results clearly show that hydrophobic polymer networks based on fatty acid exhibited relatively slow degradation, which can be further tailored by incorporation of hydrophilic components.