SBML is a widely used XML-based markup language and describes almost 50% of the attributes (Tab. S1). MathML was applied to describe the equation of the kinetic model, and the guidelines on Minimal Information Required in the Annotation of Models (MIRIAM) were applied for the consistent annotation of components such as reactants, products, and enzymes, using terms from external data repositories such as ChEBI and Uniprot . A controlled, relational vocabulary of terms, the Systems Biology Ontology (SBO) , was used to define reactants, inhibitors, activators, parameters, and the kinetic model. All files are combined into a single document using the OMEX format . Furthermore, EnzymeML uses the Distributions package for SBML Level 3