The molecule score (s) undergoes scaling using the average (µ) and standard deviation (σ) of scores for all molecules within each scoring function. The final score is the average of the scaled scores across all scoring functions (Equation ) . Let n be the total number of scoring functions, s x y the score of molecule x for scoring function y, µ y the average score for scoring function y and σ y the standard deviation of scoring function y; then the output of the Z-score consensus is given by: