Reverse osmosis (RO) membrane technology has emerged as an efficient method for the separation of solute-solvent systems. The membrane-based separation of salt ions from water solvent has been widely researched, and RO membranes have found well established applications in water desalination and wastewater purification for the supply of freshwater. In addition to salt rejection, RO membranes are also being explored for the removal of persistent organic micropollutants from contaminated waterbodies in wastewater treatment plants, to reduce health threats associated with the accumulation of such micropollutants in the environment. Besides the treatment of aqueous solutions, RO membrane technology also represents a sustainable alternative for the downstream separation of organic compounds in the chemical and fine-chemical industries, as it achieves molecular separation while avoiding the phase changes associated with thermal separation techniques such as fractional distillation or crystallisation. Promising applications for the separation of specific organic compounds by RO membranes include the fractionation of light crude oil, or the separation of xylene isomers. However, experimental findings from singular RO systems involving organic compounds cannot easily be generalised. This is because for the pore size regime of RO membranes (<1 nm), the interactions between the membrane and the solvent/solute molecules are not solely governed by a compound's hydrodynamic diameter and the applied hydraulic pressure, but they are also dependent on surface charge and a compound's affinity for the membrane material. Accordingly, steric factors alone are not a reliable feature to predict the behaviour of membrane separation systems. This is especially true for neutral organic permeants, which may show high affinity to common membrane materials, allowing them to permeate despite their large size. As such, the data landscape describing the separation characteristics of organic solutes and solvents across different RO membranes is relatively scarce. Additionally, a challenge in the development of effective membrane separation systems for organic solvent/solute systems is the finding of suitable membrane materials that are stable in the environment of the organic substances while also being inexpensive and scalable. In this work, we investigated the separation of nopinone from a mixed methanol-water solvent across a DOW BW30 RO membrane. The solute nopinone is a widely used chiral starting material, and an intermediate in the synthesis of bioactive compounds and pharmaceuticals. It is generally derived from β-pinene via oxidative cleavage of the exocyclic double bond. The BW30 membrane is a commercially available polyamide TFC RO membrane designed for brackish water desalination (MWCO ~100 Da) that has shown high rejections for the removal of persistent organic micropollutants from natural waterbodies and industrial wastewaters. This work was carried out in conjunction with the development of synthetic routes for the production of functionalised molecules from terpene feedstocks. The investigated solute-solvent system mimics an industrially relevant product mixture from a βpinene ozonolysis reactor which yields nopinone as a valuable intermediate within a chemical route for the green synthesis of paracetamol from crude sulphate turpentine. The aim of the conducted experimental work was to investigate the feasibility of employing energy-efficient RO technology for the isolation of nopinone, and to report the system-specific membrane performance parameters that characterise the separation of nopinone from methanol-water solvent across a DOW BW30 RO membrane. For this purpose, dead-end batch filtration experiments were used to evaluate membrane rejection and transmembrane flux.