The fully-coupled system represented by the fullyconnected diagram in the numerator includes, for example, the effect that the change in the water structure due to mixing with the C 12 E 6 has on the interactions between water and DS -. One way to describe this is that the C 12 E 6 monolayer polarizes the structure of the interfacial water through both excluded volume effects, as well as through hydrogen bonding interactions, which then augments the interactions of the interfacial water molecules with DS -compared to the water-DS -interactions at the AWI. Notably, this third-order structural polarization effect is absent in the three diagrams in the denominator of Eq. 10, in which only one diagram couples C 12 E 6 and water, but both species are uncoupled (disconnected) from the DS -. F