We also found that the immune system was challenging to generate neutralizing antibodies against mutations in S MHC-like 616-676 and 1014-1114 regions. It happened to gamma variant infections. The gamma variant was the SARS-COV-2 virus that caused high mortality. Rita E. Chen et al. finnd that specific monoclonal antibodies have reduced or weakened neutralizing activity against B.1.351, B.1.1.28, B.1.617.1, and B.1.526 viruses in cell culture . And the neutralizing effect of antibodies against H655Y and T1027I mutation sites is not apparent . It shows that the variants in MHC-like regions 616-676 and 1014-1114 also strengthen the immune escape of the virus, and enhance the virus's receptor engagement and membrane fusion ability.