A virus that spreads through the bite of infected mosquitoes causes Eastern equine encephalitis (EEE), a rare but severe disease. Eastern equine encephalitis virus (EEEV) is a substantial cause of infection in both livestock and humans in North America . In horses, pigs, canines, and certain animals, the disease is severe . Endemic EEEV is prevalent in the Brazilian Amazon, northern Argentina, and a significant portion of the tropical forests of South America . It has documented encephalitis in sheep, cattle, deer, South American camelids (camels and alpacas), and pigs on occasion. Additionally, infection hAdditionally, researchers have observed infection in canines, goats, bats, and small mammals, including rodents . ls who are infected with EEEV typically exhibit a systemic febrile illness that progresses to neurologic disease, which may include headache, confusion, focal neurologic deficits, meningeal symptoms, seizures, or coma, as well as neurologic sequelae .