There is a growing importance of understanding chemicals (i.e., anthropogenic and naturally produced) in environmental and biological samples, which can be referred to as the exposome chemical space. Depending on the method used to analyze such samples, a different subspace (i.e., region) of the exposome chemical space is covered. The method used are impacted by various aspects including: sample preparation, experimental analysis setup, and data processing, implying that the remainder of the exposome space is excluded that can contain highly exposome relevant or toxic chemical. Hence, variety in analysis methods is required to (un)cover as much as possible of the exposome chemical space, including the data processing side of the workflow.