While bare LIG can be used as electrode materials for electrochemical applications, their integration with hydrogels can enhance their utility even further. Hydrogel coatings on LIG nanostructures can not only accommodate various biorecognition elements, such as enzymes, but they can also bridge the gap between LIG electrodes with electrons and/or holes as charge carriers and hydrated biological living tissues, for which ionic currents serve as charge carriers . Moreover, HMs may have selective features, antifouling and/or antibacterial properties, desirable in (bio)sensing applications . Hydrogel properties can be tailored to resemble the mechanical properties of living tissues, adhere to skin or even wet tissues in vivo, show antibacterial and/or antifouling properties, and degrade on demand . This has resulted in the wide application of hydrogel membranes (HMs), in modification of LIG-based electrodes . For example, glucose oxidase (GOx) was incorporated into CS and utilized as a HM on Pt nanoparticles, decorated LIG electrodes for sweat glucose measurement . Positively charged CS chains can immobilize negatively charged enzymes via electrostatic interactions, without adversely affecting their bioactivity.