In some cases, reliance on these metrics may lead to misleading insights regarding the practicality of realising hypothetical MOFs. For example, organic molecules with SA scores > 6 are generally considered difficult to synthesise, and so linkers may be considered synthetically viable below this threshold. According to this criterion, almost all the c max p optimised linkers from Figure (a) would be deemed feasible, as indicated by the SA score distribution in Figure (a). However, experts in MOF synthesis would likely have reservations about the stability of MOFs created with some of the "synthetically accessible" linkers. This indicates that the SA score may not necessarily reflect the suitability of an organic molecule as a linker. Conversely, the distribution of SC scores among the same set of optimised structures correlates much better with the "linker-like" character of organic molecules. For instance, linkers with SC scores > 4 tend to be very large, highly asymmetric molecules with connection points oriented in such a way that the MOF structure would likely collapse upon activation. In other words, these molecules are unlikely to extend beyond pure theoretical intrigue. Linkers with SC scores < 4, however, have far more realistic features (such as fewer bulky side chains, reasonably oriented connection points, and lower molecular weights).