Perturbations applied to the dissolved oxygen concentration in the feedstock demonstrated that even at parts-per-million (ppm) levels, dissolved oxygen had a substantial accelerat-ing effect on film growth. These findings highlight the importance of considering oxygen chemistry in the modeling of polymer fouling within distillation columns. The developed fouling model provides insights into the role of oxygen in the fouling process and its impact on film growth, contributing to a better understanding of fouling phenomena in industrial distillation operations.