While sequential operation where enzymatic pre-treatment is followed by photoreforming provides better control of the individual steps, there are several potential advantages of integrated chemoenzymatic photoreforming from an applied point of view. Integrated operation results in a lower capital and operational cost as it requires only a single combined reactor. It also provides the potential for accelerating the PET breakdown and making the process more energy efficient via heat-management. An integrated system exposes the enzymes to solar (IR) heat, which would go to waste in a decoupled process where PET pre-treatment occurs in the dark. Thus, our demonstration of photoreforming employing enzyme pre-treatment of robust plastic films to generate H2 in a single chamber under benign conditions provides the basis for applied development of this technology.