The KiSSim fingerprint encodes the 85 KLIFS pocket residues in the form of physicochemical and spatial properties. Physicochemical properties include pharmacophoric and size features, side chain orientation, and solvent exposure; spatial properties include each residue's distance to the pocket center as well as to three subpockets and the first three moments of the resulting distance distributions (Figure ). We investigate here the fingerprint feature value distribution across all KiSSim fingerprints. The value distributions for pharmacophoric and size features differ depending on the feature type (Figure ) and the residue position (Figure and). For example, the amino acid size is more evenly distributed than the aromatic or charge feature, since most amino acids are neither aromatic nor charged (Figure , left). Since the five pharmacophoric and residue size features encode -in an abstracted manner -the pocket sequence, features are more robust at more conserved pocket positions than at other positions; examples are the conserved salt-bridge between residues 17 and 24 or the DFG residues 81-83 (Figure ). Spatial distances range between 2-33 Å (Figure , middle), however, depending on the residue position, the values cover only a subset of this range. For example, the hinge region residues 46-48 are close to the hinge region center, while further away from the DFG region center (Figure ). Distances from subpocket centers to regions such as the G-rich loop (residues 4-9), the αC-helix (residues 20-30), and the DFG motif vary more than for example to the hinge region, which agrees with knowledge on more flexible vs. more stable regions in the kinase pocket. The spatial moment features describe the distance distributions between the pocket residues to the subpocket centers. They show lower variability for the mean and the standard deviation but high variability for the skewness (Figure , right).