For the link prediction an up-to-date network was used to minimise the rediscovery of already known reactions. This meant that the size of the overall network had to be reduced to be able to process it given the available computational resources. The same network as used during the testing of the accuracy of the link prediction algorithm was used, however, instead of adopting an "all-to-all" wiring scheme it was instead decided to adopt a scheme registering and connecting only the heaviest reactant to the heaviest product, as already discussed in which resulted in a network of 161,760 chemical species and 132,539 edges, each representing a reaction record in Reaxys.