Inspired by the natural protein-mediated processes known for fusion pore stabilization , we describe here an artificial alternative. We show that SMACs have the ability to stabilize the fusion pore in terms of its life-time. When located inside the organelles connected by the fusion pore (above and below the bilayers) SMACs bind to the membranes, diffuse towards the water channel and prevent the fusion pore from collapsing. Remark-ably, the stabilization of the fusion pore is mainly dependent on the amount of intra-organelle SMAC:lipid contacts, with no significant intervention from extra-organelle SMACs (located in the cytosolic water, between the bilayers, see figure ).