In the context of machine learning the QCore package of Iambic (formerly Entos) implements GFN1-xTB and the ML method OrbNet which is based on the GFN1-xTB intermediates and outputs. An open source framework for tight binding development was created with the TBMaLT package, which has basic support for the xTB core Hamiltonian and is integrated with the dxtb library. Furthermore, many software packages are built with support for xtb or tblite. This includes tools for molecule generation like Architector, 60 AGOX, 61 cgbind, or stk, reaction network exploration tools like ChemDyME, or Chemoton. Finally, xtb is shipped now as a standard component of many established chemistry packages, like Orca, Turbomole, Gaussian 69 and OpenMM 70 or integrated via tblite directly into the packages like QCxMS, 71 DFTB+ and NWChem.