Overall, our tests on 3-iodotoluene indicate that for larger ligands and/or more confined environments, standard MC move proposals perform dramatically worse than for toluene, in keeping with what might be expected for large moves in condensed-phase systems. This, combined with the overall flexibility of the NCMC approach in combining some of the advantages of MD with those of MC, indicates that this approach may be a good general strategy for ligand binding mode sampling. Additionally, this work highlights how important it is not just to monitor the overall acceptance rate of moves, but how the acceptance rate of moves is coupled to the size of moves; here, NCMC results in high acceptance of large moves, while MC does not.