(Z)-1 RMSD for all ten models clearly shows that in general the (E)-1 and (Z)-1 conformations remain relatively close to their initial binding poses. A diversity of behaviours can be observed for the different (E)-1 and (Z)-1 complexes during the simulations (Figure ). In in some cases, (Z)-1 binding to the DNA is very stable with its binding mode staying close to the initial one whereas in others, the oposite behaviour is observed with (E)-1