These simpler properties may have little direct biomedical or economic importance, but they are informative because they can isolate and test the ability of a computational method to predict properties that play a role in important problems. For example, the hydration free energies of organic molecules are relevant because protein-ligand binding causes partial dehydration of both the protein and the ligand. If the free energy changes associated with these dehydration events is erroneous, it will be difficult to compute an accurate binding affinity. Simple problems also require less conformational sampling, by e.g., molecular dynamics and Monte Carlo methods, so they maximize the precision of the results and are relatively inexpensive to compute, enabling broader participation and testing of more methodologies.