Besides practical considerations, some gases are also challenging to activate under conditions suitable for synthetic organic chemistry due to their inert nature. Notably, achieving selective functionalization of C(sp )-H bonds in saturated volatile hydrocarbons like methane, ethane, propane, and butane represents a significant goal in modern C-H activation chemistry. Despite recent advancements, efficiently functionalizing gaseous alkanes remains a formidable task. This challenge is exacerbated by their unfavorable thermodynamics, with bond dissociation energies (BDE) reaching up to 105 kcal/mol, and compounded by issues related to chemoselectivity, solvent compatibility, and solubility (Figure ). Consequently, these reactions often demand harsh conditions, characterized by high temperatures and pressures, which may not align with the delicate nature of most organic molecules.