A total of 50 DEL-ML predicted compounds were purchased from Enamine, with only 48 being successfully delivered. These were screened using SPR against the same WDR91 protein construct (residues 392-747) that was used for adinity-based selection in the DEL screening. The primary screening was conducted at a single compound concentration of 45 µM. Eleven of the 48 compounds were identified as preliminary hits (Table ) and subjected to dose-response titration by SPR for hit confirmation. The titration was performed against both the WDR domains of WDR91 and WDR12, with WDR12 serving as a negative control to assess compound selectivity. Seven compounds were confirmed as selective hits for WDR91 through dose-response titration, resulting in a 15% hit rate. None of these compounds interacted with WDR12, indicating a preference for WDR91.