To verify this hypothesis, we first incubated chemically synthesized 2Z-GGPP (Methods and Supplementary Figure ) with Bnd4 and AlbS in vitro, in an attempt to obtain 2Z-isomers of respective eunicellane products. Regrettably, we were only able to purify compounds 9-12 and were unsuccessful in synthesizing our intended compounds 2Z-benditerpe-2,6,15-triene and 2Z-albireticulene (Extended Data Fig. ).