Here we briefly lay out, how we can control and predict the statistical accuracy of the computed transport properties using the "OrthoBoXY"-approach for homogeneous liquids and liquid mixtures. We aim to determine rules for how to properly set up MD simulations to achieve a certain level of accuracy for both D 0 and η, such that we can plan for the best return on our investment. In this section, we will employ simulations of TIP4P/2005 water at a density of ρ = 0.9972 g cm -3 and a temperature of T = 298 K as our frame of reference. We are using the same simulation setup as discussed in Ref. . The simulations were, however, extended to a simulation time of 40 ns to further improve the statistical accuracy of the computed data.