Traditionally, in order to activate the methyl groups of pyridine ring for Knoevenagel condensation, incorporation of the electronwithdrawing substituents or quaternization at pyridine ring is necessary. Here, our attempt is to take use of the Lewis basicity of pyridine moiety for promoting the Knoevenagel reaction of a newly designed pyridine-based monomer 2,2',6,6'-tetramethyl-4,4'bipyridine (TMBP), bearing four pyridylmethyl terminal groups. Some previous works reported that methyl-substituted pyridine derivatives were facile to conduct Knoevenagel reaction with aromatic aldehydes in a mixture solvent of acetic anhydride and acetic acid at ca. 135 o C with moderate yield (< 60%) . Considering the relatively weak reversibility of such carbon-carbon double bond formation reaction, we decided to raise the reaction temperature in a mixed solvent of benzoic anhydride and benzoic acid for the preparation of model compound and COFs .