Recently, early stage O-sulfation reaction between aryl fluorosulfates and silyl ethers was reported leading to the formation of sulfuric acid diesters, which are subsequently reduced to the target sulfates by hydrogenolysis step. This strategy was applied to a wide range of small molecules such as monosaccharides, disaccharides, an amino acid, and a steroid. Liu and co-workers have explored the SuFEx reaction between silyl ethers and aryl fluorosulfates to introduce sulfate diesters on carbohydrate and non-carbohydrate scaffolds. This was followed by a deprotection step of the aryl sulfate monoester resulting in the formation of O-sulfate molecules (Scheme 16). This optimised method was applied to different small biomolecules such as monosaccharides, disaccharides, an amino acid, and a steroid (Figure ). Figure . Scope of some sulfated biomolecules using SuFEx approach.