The earlier report of drug repurposing mainly focused on a single target option we represented the holistic approach of targeting all the viral proteins for effective anti-COVID19 activity. The combination suggested will effective on the nonstructural proteins, structural proteins of COVID19 and also included drug the anti-inflammatory with synergic anti-COVID19 activity. Comparative computational analysis of the proposed drug is superior to currently clinically used drug combinations. Which, reflects the possibility of the promising effect of the proposed drug combination in further clinical applications.