On the forward prediction tasks the accuracies achieved are similar (albeit slightly lower) to the accuracies reported by by Schwaller et al. (88-90% top-1 accuracy when trained on the USPTO_MIT dataset), though the accuracies are not directly comparable since different subsets of USPTO were used. As expected the performance with separated agents is higher than mixed, since it is an easier task, and it is encouraging to see that the models get stereochemical information correct most of the time. Accuracy with the retrosynthesis model on the held out test set was roughly 50%, which is similar previous work on retrosynthesis . It is interesting that prediction accuracy on the non-USPTO data was similar on the forward prediction tasks, but markedly worse on the retrosynthesis task.