The cheminformatics toolkit RDKit recently integrated an extensive scaffold network functionality into its range of capabilities . The module named "rdScaffoldNetwork" primarily offers the generation of scaffold networks based on a HierS-like scaffold dissection (no splitting of fused rings). Custom fragmentation rules can be added in the form of reaction SMARTS . In addition, more abstract atom-and bond-generic scaffold representations can be generated. The new functionality has been employed in a study evaluating different approaches to automate chemical series classifications in medicinal chemistry .