(3.3.2) De Proft and Geerlings : A remark aside from the validation itself is the use of a certain DFA after its validation. It can be asked, once a given DFA has proven its merits in a certain domain, that this DFA should additionally be benchmarked for problems (compounds, properties, reactions) that do not differ markedly from those for which the DFA has been successfully validated in the literature and for which one can reasonably expect that it will perform well for the problem at hand (cf. the notion "level of trust" introduced in contribution (3.2.1)).