(1)Telomerebinding domains Chromo (IPR000953) is a CHRromatin Organization Modifier. The condition of repressed gene expression that can be seen in cells is caused by these proteins changing the structure of chromatin to a more compact form of heterochromatin. One of these proteins, Polycomb, has demonstrated the crucial role of chromodomains in targeting chromatin. The yeast protein CHD1 and the mammalian DNA binding/helicase proteins CHD-1 to CHD-4 both contain chromodomains. Chromodomains play a mechanistic role in targeting chromodomain proteins to specific regions of the nucleus. The targeting mechanism may entail interactions between proteins and/or between proteins and nucleic acids.