The average effect size shown in Figure is small, however, as shown in Figure and 9, the average trends hide a wide array of responses to changes in conformational ensemble size and the effect of ensemble size can be significant and varied. For the 0.5 Å RMS filtered set there are 29 of the 102 targets where the best F1 score is achieved using a single conformer compared to 16 where the best F1 score is achieved using an ensemble of 200 conformers.