The synthesis of copper (Cu) nanoclusters (NCs) has emerged relatively recently compared to their gold (Au) and silver (Ag) counterparts, primarily due to the inherent challenges in stabilizing the NCs during synthesis, which are prone to oxidation and decomposition, especially at ambient conditions. However, recent advances in synthetic methodologies have made it possible to stabilize Cu NCs. Early efforts focused on Cu-hydride NCs, which are stable at low temperatures, but the development of thiolate-and alkynecapped Cu NCs has since enabled the stabilization of these clusters under ambient conditions. After stabilization, Cu NCs exhibit remarkable properties arising from quantum confinement and their discrete electronic structures. These distinguish them from larger Cu nanoparticles, as the electronic and optical behaviors shift dramatically at the nanoscale, unlocking a wide array of potential applications. A key advantage of Cu NCs lies in the variable oxidation state of Cu and high surface-to-volume ratio enhances their versatility for catalytic applications. Additionally, the natural abundance and lower cost, compared to precious metals like Au and Ag, make Cu NCs highly attractive for practical and large-scale catalytic processes.