Analytical measurements were performed on an Accela LC system coupled to a Q Exactive™ HF mass spectrometer (both Thermo Scientific) using electrospray ionization (ESI) in both positive (+) and negative (-) modes. BEH C18 reversed phase (RPLC) (1.7 μm, 2.1×150 mm) and SeQuant® ZIC-pHILIC polymer (HILIC) (5 µm, 150×2.1 mm) columns were used, in separate runs, to detect a broader range of chemicals. The HRMS was operated in full scan profile mode with scan range 60-900 m/z using the methods described in Talavera-Andújar et al . QC samples were analyzed prior the first sample and every three or four sample injections.