To a flame-dried 20-mL microwave vial equipped with a magnetic stir bar was added azedaralide and). The reaction vessel was then transferred to a 0 °C ice-water bath, and PBr3 (130 µL, 1.38 mmol, 1.2 equiv) was added dropwise. The reaction vessel was then removed from the ice-water bath, and allowed to warm to room temperature.