For the DIADS, only 0.88% of the transformed structures can be highlighted as potential ACs, based on compound 15, revealing that transformation rules serve as a powerful tool for designing and exploring new compounds. Conversely, no ACs were identified in PYRDS; however, 0.42% of the compounds contained the methoxy-group as featured by structure 15. Nevertheless, hydroxyphenyl pyridin-4(1H)-one moiety is associated with the biological activity as demonstrated by the potent inhibitor 4 described in section 3.3.