At the time of the spill, ~1680 tons of plastic debris was released, of which a sizable portion was burned. By June 2021, ~1610 tons of plastic, debris, and contaminated sand had been recovered and has since remained siloed in warehouses. Part of the prolonged containment of the waste has resulted from the uncertainty of its hazardousness and the methods for its appropriate disposal. From the FACTORIAL bioassays, it appears that the bioactivity of the chemicals associated with the pyroplastics largely reflects that of presumed and recognized carcinogenic PAHs, specifically BbF and BkF, despite being a complex mixture of thousands of compounds. This finding suggests that the material should be handled similarly to other combustion-derived residues (e.g., from biomass). Conversely, any chemicals associated with the white nurdles appear to pose a comparatively marginal threat, eliciting relatively minimal bioactivity at their expected concentrations. Nonetheless, the bioavailability of the associated chemicals, which controls their effective dosage, remains to be determined. For the stray pyroplastic still in the environment, continued monitoring is necessary. Pieces of pyroplastic collected nearly a year after the spill largely retained quantities and compositions of associated chemicals capable of eliciting bioactivity comparable to when they first spilled. As the material fragments into smaller pieces, other organisms will become susceptible to it, and other modes of toxicological action will likely arise (e.g., submicron-sized plastic particles loaded with relatively high levels of contaminants). With the detection of pyroplastics across much of the globe and recently in fish,