Another aspect is that we may overemphasize the accuracy of what we take as a reference. Herbstein discusses several factors that may affect the measurement of such basic data as singlecrystal unit-cell dimensions. Cioslowski et al. show that experimental error bars are often missing or can be quite large. Sometimes advanced wave-function calculations are not pushed far enough to be used as a reference. 283 (3.2.8) Adamo and Ciofini : In some cases, determining how accurate DFAs need to be is probably even more difficult than determining how accurate existing DFAs are in fact for a given property. Indeed, even for a single, well-defined property, the target accuracy will depend strongly depend on which question we aim to answer (as already pointed out by Savin in contribution (3.2.7)). The necessary accuracy will depend strongly on the type of "interaction with the real world" is desired, following the excellent classification given by Kronik in contribution (3.8.5): confirmation, interpretation, or prediction. In our experience, this is particularly true for the interpretation and prediction of excited-state properties of molecular systems.