The metals used in medicine were noticed after their successful works, such as sodium vanadate used in diabetic patients, and gold benefited by reducing inflammation . For example, it was discovered that cis-diamminedichloridoplatinum(II) (cisplatin) treatment for cancer and its cytotoxic effect in the late 1960's . After FDA approval in 1978, it has been utilised to treat several cancers, especially bladder, testicles and ovaries. The rate of accomplished treatment with cisplatin is over 90% for patients having testicular cancer . However, cisplatin has been suffering from limitations, such as neurotoxicity, ototoxicity and nephrotoxicity, which results in painful treatment and restricts the usage of cisplatin .