The data curation mainly consists of a template approach, where a set of reaction SMARTS are used to generate all possible products from detected coupling partners. A reaction is then classified as being correct, if a reported product in the reaction SMILES from Reaxys matches one of the generated products. However, only reactions leading to a product with a molecular weight (MW) of ≤ 600 g/mol are considered (average MW = 334 g/mol), and reaction duplicates are removed. The template approach allows us to divide the reactions into different categories such as inter-or intramolecular reactions leading to either α or β products or a mix.