The third fragment growing strategy started from fragment, PDB-ID; 2W6Z, and was found to bind to three Anchor-category residues Lys-A-159, Glu-A-201, and Leu-A-204 and two Accessible-category residues, Ile-A-157 and Tyr-A-203, (Figure . C). A corescaffold modification morphed into compound (PDB-ID; 2W6Q) which maintained the same Anchor-category and Accessible-category interactions. The compound showed a noticeable increase in LE and total better IC50 value. This is due to a Transient-category interaction with the Lys-A-202, which was followed by growing the molecule into a more hydrophobic sub-pocket found between residues, His-A-209 (Non-hotspot-category) and Ile-A-437 (Accessible-category).