ShaEP method -quantifying similarity of conformations both in terms of shape and distribution of electrostatic potential -showed significant overlap even in such counterintuitive cases as Thalidomide parent and its Felbamate progeny (Figure ): Although the latter's 2D structure appears "extended", its 3D conformation is more "cyclic" due to hydrogen-bond interactions (see superimposed conformations in Figure ). Overall, the 3D similarity calculated by ShaEP and averaged over 133 parent-progeny pairs we consider is 0.75 (0.91 in terms of the shape-similarity contribution and 0.61 in terms of the distribution of electrostatic potential). In a broader context, these figures can be compared with the similarities between drugs that are known to act against the same (non-COVID-related) targets. For instance, within the family of 41 medications targeting Cox-2 (e.g.