The latter characteristic of drug molecules as opposed to NP is also considered the reason for the lower time it took on average to dissect the DrugBank structures. It must also be noted that these processes, the pure dissection of each molecule, scale linearly with the number of molecules and can be parallelised in multiple threads for further speed up. In a second step, it was measured how much time it took to construct scaffold forests and networks from an increasing number of molecules taken from the COCONUT subset and DrugBank, respectively. Figure shows the results for the area of molecule number of DrugBank (0 -11,127 molecules) and Figure for the area of the COCONUT subset (0 -39,324 molecules). Exponential approximations show that the individual processes scaled between O(N 1.2 ) and O(N 1.6 ). This comparatively good scaling below a quadratic behaviour is most likely due to the stepwise construction of the scaffold hierarchies that repeats the two steps of scaffold dissection and integration for each molecule instead of generating all scaffolds first and constructing the hierarchy later using substructure searches to establish parent-child scaffold relationships.