Serial Crystallography (SX) is a technique within the field of structural biology that involves collecting diffraction data from numerous, often hundreds or thousands, of micro-or nano-crystals to assemble a complete dataset. Unlike traditional crystallography, which collects data from a single, large crystal and from multiple (fixed) viewing angles, serial crystallography collects a series of diffraction patterns coming from small randomly oriented crystals on a jet (see Fig. ) and merges them to determine the threedimensional structure of macromolecules.