(1) the possibility of low dose administration because there are no concerns about content uniformity and (2) the flexibility of dose adjustment based on the amount of liquid. The component and composition of the developed oral solution are shown in Table . We added ascorbic acid as an antioxidant to prevent the degradation of S-892216 in PEG 400. Details of antioxidant selection are provided in Tables and. PG was added to adjust the viscosity.