Organic crystalline solids are a key delivery mechanism in product formulations for a number of industries, such as pharmaceuticals and agrochemicals. The physical properties and the thermodynamic stability of the solid phases of organic compounds are dependent on 1) the chemical compound in question, and 2) the arrangement and conformations of all molecules in a 3-dimensional lattice. Polymorphism, the possibility of a compound adopting multiple crystalline forms in the solid state, plays a key role in product development, such as during solid form selection. Different polymorphs can be observed experimentally, either under different conditions or concomitantly, and the differences in their structure can have a profound impact on the physical properties of the crystal. The effects of polymorphism are widespread, hence any early knowledge pertaining to the thermodynamic stability of crystal structures under a given set of conditions can be highly valuable in accelerating product development and avoiding disastrous situations during manufacturing . Unfortunately, there are limited guidelines for knowing which crystallisation conditions might promote polymorph formation, or if a polymorph even exists .