We reasoned that other drugs might similarly be detectable from a fluorescence signal. Some of the most significant concern at present (at least in the UK) comes from the increasing reports of overdoses with synthetic opioids (nitazenes). Sadly, these drugs appear to be responsible for a large number of deaths in the heroin using community in the UK and the concern is that they become a feature of the wider drug supply. We have therefore explored the potential to detect nitazenes in e-cigarette liquid. We find similar to THC, that combining fluorescence detection with photodegradation yields a novel signal that can be identified even in e-cigarette liquid. Whilst we acknowledge nitazene containing e-cigarettes are sparsely reported the UK at this time, and so we do not have real world seizure data, these findings support the notion that the detection is feasible.