Click chemistry is a powerful and efficient method for rapidly connecting chemical fragments, enabling the modification of biologically active molecules . Among the various types of click chemistry, SuFEx (Sulfur(VI) Fluoride Exchange) reactions have emerged as a reliable resource for drug discovery , chemical biology , polymer chemistry , and surface modifications . In particular, the unique properties of the sulfur(VI)-fluorine bond make SuFEx reactions highly versatile, allowing for the formation of covalent bonds under mild conditions . The S(VI)-F bond is highly stable, allowing it to withstand harsh conditions, yet readily cleavable in the presence of a suitable activator or reaction partner . Consequently, the versatility and efficiency of SuFEx reactions make them a valuable tool for researchers in a wide range of fields, including synthetic chemistry, drug discovery, and materials science .