This receptor is closely associated with both hormone-dependent and hormone-independent tumors, and paly crucial role in the progression and development of breast cancers . The Jab1 (Jun activation domain-binding protein 1) have an important role in the development and progression of breast cancer in association with ER-α. An study of breast cancer where 283 ERα-+ve breast tissues was examined by immunohistochemistry showed a significant positive correlation between Jab1 and ERα expression . Among several strategies, suppression of in situ estrogen production through aromatase inhibition is the promising approach for hormoneresponsive breast cancers. Aromatase is a cytochrome P450 enzyme (CYP19) and is the rate limiting enzyme in the conversion of androgens to estrogens .