Figure shows the error distribution for each molecule calculated for 5 methods from submissions that were determined to be consistently well-performing (method names: TFE MLR , Chemprop , COSMO-RS , ClassicalGSG DB3 , TFE-NHLBI- In some cases, log P SEM values are too small to be seen under the data points. The best-performing methods were made up of three empirical methods (ClassicalGSG DB3 , TFE MLR , Chemprop ) and two QM-based physical methods (COSMO-RS , TFE-NHLBI-TZVP-QM). Details of the methods can be found in Section 3.1.2 and performance statistics are available in 2. Method NES-1 (GAFF2/OPC3 G) was selected as the representative average method, which has a median RMSE.