The P-score gives a score between 0 and 1 which is the normalization range of all descriptors included. A P-score of closer to 1 means that this binding mode is highly prioritized as a stable conformation of the protein-ligand complex, with a long residence time (t) and a low interaction energy (ΔE FMO ) (True positive). A pose with a P-score closer to 0 is likely to be the least favorable binding mode for the protein-ligand complex, which can be a result of having the shortest residence time, the highest interaction energy, or both combined, (True negative).