Interestingly, although the mixed fine-tuned model's prediction is accurate for 4D., it was not counted as round-trip accurate due to the forward model predicting a condensation reaction with both the carboxylic acid and the nitro group instead of just a single condensation with the former. This highlights a limitation of metrics based on round-trip accuracy, where the model's prediction is only assessed by another model that is not 100% accurate instead of comparing the prediction to those reported in the literature or assessed by skilled organic chemists. Finally, in 4E. the mixed fine-tuned model correctly predicts the disconnection of indazole, while the baseline model suggests a Boc protection of the nitrogen without simplifying the molecule. While the ability of the model to suggest protection reactions is notable, as they are crucial parts of synthetic routes, this specific protection is unnecessary and might lead the model to predict a cycle of protection/deprotection reactions, preventing further disconnections of the molecule.