bases. Generally, and as can be seen in Figure , the G-quadruplex region remains stable in all systems except for the model2-E(1) complex. In the model2-E(1) complex, G28 underwent a structure change and moved way from G17, G21, and G25, thus disrupting the hoogsteen base pairs which lead to the increase in the RMSD observed in Figure . The RMSD profiles for the whole DNA segment are higher than the G-quadruplex region, thus highlighting the highly flexible nature of the duplex region (Figure ).