Notably, compounds 2-3 showed potent antibacterial activity against both the Gram-positive bacteria )Staphylococcus aureus and Micrococcus tetragenus) and the Gram-negative bacteria (Escherichia coli, Vibrio anguillarum (V. anguillarum), and V. parahemolyticus). Compound 3 displayed MIC of equal to or less than 2.5 µM against all tested bacteria, whereas compound 2 exhibited MIC of equal to or less than 2.5 µM against all tested bacteria except V. anguillarum and V. parahemolyticus against which it showed MIC of 25.0 µM .