The affinity between the inhibitor molecule and the TRPV4 target is a key metric for evaluating the effectiveness of molecular candidates. Figure shows the affinity energy distribution of molecules designed by TRPV4-Gemma-3B. The data cleaning and statistical processes were conducted using the same standards as for the data in Figure . Based on the distribution shown in the figure, the maximum, mean, and median affinity energies of TRPV4-Gemma-3B-designed molecules are slightly lower than those of the sample data. This is primarily due to the significantly lower number of TRPV4-Gemma-3B-designed molecules within the 9-12 and 7-8 affinity energy ranges compared to the template dataset.