In addition, subgroup analysis comparing the performance of the best algorithms for each dataset, has also shown that the RDK7 dataset still produced a high average R 2 result of 0.787 (Fig. ). While this result was the highest compared to the other molecular features, it only showed statistically significant differences when compared with the CAT2D, MACCS, 34 MOL2VEC, PUBCHEM, and RDKDES datasets (p < 0.05) (Fig. ). Following the meta-analysis and subgroup analysis results, RDK7 molecular fingerprints were selected for constructing the QSAR model.