The second step of this workflow involved efficiently scoring candidates through the CATHEDRAL script, using a custom confidence level system. Hence, a confidence level was assigned to 52 compounds, annotated with at least two annotation tools. This original scoring strategy markedly enhances the compound annotation reliability and reinforces the structure-organism pairs. This approach also reduces the requirement for tedious manual analysis, including successive purification and structural elucidation steps to confirm the presence of compounds in the studied matrix. As a result, it accelerates chemical profiling through dereplication.