Having in mind that the S and M forms participating in the same rotation cycle characterize with the opposite chirality, this problem is equivalent to reversing the relative stability of these forms. This effect can be achieved through rotation of the PFCN switching unit, i.e., through its axial chirality inversion, as illustrated in the central panel of Figure . Upon such rotation, the S R isomer transforms into M R which is then expected to undergo quick thermal relaxation to form the S S structure. Once formed, S S can participate in the reversed chirality, i.e., in the S -chirality motor operation cycle whose ground-state potential energy landscape, shown in the left panel of Figure , mirrors that of the R-rotation, discussed previously. Importantly, in the absence of an external potential, the switching unit rotation requires substantial amount of energy: about 680 meV (15.7 kcal/mol). This value is about 25% smaller than the energy barrier protecting the system from the ground-state S → M forward rotation, corresponding to the tall peaks in Figure