The Ni/TiO2(PC500) catalyst exhibited a totally different behavior. Indeed, increasing the reduction temperature from 500°C to 700°C resulted in a gradual decrease in the HMF conversion, that dropped down to 66% and 25% for a reduction temperature of 600°C and 700°C, respectively. This decrease was accompanied by a strong decrease in the 5-MF selectivity and an increase in the selectivity to BHMF, that however reached only 64% when reduced at 700°C. This resulted only to a very low yield to BHMF of 14%. In that case, by contrast to the behaviour of the Ni(pre)/TiO2(ALG) catalyst, increasing the reaction duration and tripling the amount of catalyst only allowed to increase the HMF conversion from 25% to 49%, while no selectivity switch was observed, with moderate selectivities to 5-MF and BHMF of 33% and 45%, respectively. This resulted in low yields to 5-MF and BHMF of 16% and 22%, respectively.