Throughout history, different natural sources have been used as valuable suppliers of biologically active compounds with diverse bioactivities that can be used to develop new drugs . Marine organisms and microorganisms were among the valuable sources of new natural products . Microbial secondary metabolites have been known for their chemical diversity and broad range of bioactivities . Marine microorganisms have been considered as highly productive sources of physiologically active compounds including peptides, anthraquinones, polyketides, terpenes, and alkaloids . Some marine-based compounds have been approved as drugs with different pharmacological uses , while several others are under different clinical trials before their approval as new drugs .