The method developed in our earlier study estimates the temperature-dependent solvation free energy at a solvent's saturation pressure, and thus ΔΔ𝐺 ‡ solv is also estimated along a solvent's saturation curve. This indicates that the gas phase rate constant (𝑘 gas ) in eq 4 should correspond to the values at the saturation pressure for pressure-dependent reactions. Yet, our earlier work demonstrated that the method can provide reasonable predictions of solvation free energy at higher pressures as well as long as the temperature is not too close to the critical temperature of the solvent (𝑇 < 0.8𝑇 c ). Near a critical point, the pressure effect becomes more significant, and therefore our method is expected to have a higher error if the pressure deviates from the saturation pressure at elevated temperatures (0.8𝑇 c < 𝑇 ). Moreover, our method assumes the dilute limit, which may not be valid if a substantial amount of a reactant is dissolved or if the solvent is a reactant.