The temperatures in the CombiSolu-Exp database range from 243 to 364K. Since these temperatures are close to room temperature (298K), it is assumed reasonable to neglect the temperature dependence of the dissolution enthalpy. To calculate log(S X,T ) at temperature T with Eq. 9, the solid solubility at 298K from section is used together with the dissolution enthalpy ∆H diss,298K . The dissolution enthalpy at 298K is calculated from (i) the new transfer learning model predictions for ∆H solv,298K , (ii) the machine model predictions for solute parameters, 31 and (iii) the correlation for ∆H sub,298K published by Abraham and Acree 30 (Eq. 10).