Through this discussion, we have shown that MOFs and SERS, individually, hold a potential towards the development of sensing platforms for aromas and flavors profiling. It is logical to assume that the combination of both approaches, i.e., the generation of MOF-based SERS substrates will provide a powerful approach to this field. To the best of our knowledge, there is only one report addressing the use of MOF-based SERS substrates towards such a goal.