A comprehensive understanding of how chemical species transport and reactions can elucidate the pathogenesis of cardiovascular diseases. In atherosclerosis, oxidized low-density lipoproteins (ox-LDL) play a pivotal role in initiating and propagating inflammatory responses within arterial walls. These processes lead to endothelial dysfunction, smooth muscle cell migration, and extracellular matrix remodeling . Disruption in these balanced interactions results in significant biomechanical instability, such as impaired calcium transport within the heart muscle cells, which alters the normal contraction and relaxation cycle of the heart, a scenario common with heart failure.