We have recently described an asymmetric total synthesis of lepadiformine A ( ) by means of a tandem Au-catalyzed alkyne hydroamination/iminium formation/allylation reaction of 12 (Figure ). The resultant spirocyclic pyrrolidine 13 was transformed into 11 over seven steps via the formation of the piperidine ring. In this work, we envisioned that 13 should serve as a pluripotent intermediate toward collective synthesis of 1-10. Specifically, the perhydropyrrolo[2,1-j]quinolin-7one skeleton 17 would be accessible through a tandem chemoselective oxidation/intramolecular aza-Michael addition/epimerization of amino alcohol 14 (Figure ). Epimerization at C5 position has been shown to be facile under acidic or basic conditions. The synthesis of cylindricines A-F (1-6) is summarized in Scheme 1. As described previously, 9 oxidative cleavage of the