Thin layer chromatography studies could reveal polarity and estimated logP values for Naproxen and Naproxen-PEG conjugate. These were compared against commercial forms of drugs-ibuprofen and acetaminophen. It should be noted that silica gel is highly polar and is capable of hydrogen bonding. A higher Rf value is indicative of relative nonpolar behavior as these molecules are capable of traversing the plate rapidly. More non-polar, hydrophobic compounds will have a higher logP. In comparison to the common OTC drugs, naproxen exhibits the most nonpolar behavior.