It is too expensive to use tighter T CutP N O thresholds for most models in ENZYMES22, but we have also briefly looked at results using T CutP N O = 10 -8 and T CutP N O = 10 -9 for the two smallest models in section S3.1.1 of the Supporting Information as an additional test of the accuracy of CPS (6,7). We see similar trends in the correlation energies for each structure as well as REs and BHs to those seen for the small test set in figures S2 and 2. While the REs and BHs do not appear to fully reach convergence within the range tested, the changes in energy beyond CPS (6,7) are small. At the CBS (3,4) level, CPS(6,7) has an average difference from T CutP N O = 10 -8 of 0.06 kcal/mol across the 6 energies associated with As-pDC model 0 and HKMT model 0, with the largest difference being only 0.13 kcal/mol. For HKMT model 0 T CutP N O = 10 -9 values could also be achieved, and CPS (6,7) differed by less than 0.1 kcal/mol for all three energies.