In this article, we present a de novo SBDD method capable of generating molecules in the hotspot (active site) of a protein or any other biomolecule completely from scratch by building them one atom at a time. Many proteins in the human body are in dire need of small-molecule drugs, which, if found, could revolutionize medicine for specific ailments. However, by contemporary methods, these regions have been labeled undruggable , which implies that designing a ligand to bind to the required region is unlikely to succeed owing to weak/poor interactions or the absence of sufficiently strong or precise interactions. These criteria are often too restrictive to allow the heuristic design of suitable candidates . There is also a growing concern for newer scaffolds in antibiotics. Owing to the rapid development of multi-drug resistant bacteria 8 , computational methods for de novo drug design could give us an advantage in this constant arms race.