The resulting fibers exhibit a smooth fiber morphology, and for direct-written neat polymer a reasonably good stackability and alignment of the MEW fibers (Figure ) was achieved for 20 alternating layers while for the different polymer:IND ratios 15 alternating layers could be printed. All processed polymers and polymer:IND blends show round-shaped fibers without flattening in-between the layers. The fiber diameters of all processed materials are between 25 to 50 µm (Figure ). However, no general trend is visible as the printing parameters were individually adjusted for the neat polymer and the polymer:IND blends (Table ), significantly influencing the resulting fiber diameters. By increasing the hydrophobic drug content, the stackability of the fibers deteriorates leading to bigger gaps between the stacked layers. This might be caused by increased repulsion between the hydrophobic drug particles and therefore, processed fibers. The distribution of IND in the printed scaffold was investigated by placing the scaffold under UV light, which revealed in a homogenous fluorescence emission (Figure ). Using IND as oral capsules or suspension, the drug loading is commonly based on release rate, age, type and severity of the patient's condition and is around 20 -100 mg per unit. However, in freeze-dried sublingual tablets, the drug loading has been investigated at around 25 mg per unit. When processing the blend polymer:IND 1:2 (w/w) into scaffolds with 15 alternating layers, the sample weight is around 90 mg and therefore, drug loading is about 60 mg. As MEW is a multi-parameter process and the scaffold design is controlled via the G-code, the dosage of IND in MEW printed scaffolds could be readily adjusted by, for example, changing the fiber diameter as required. The diameter can be varied via the applied pressure and/or the printing speed. Furthermore, the scaffold design can also be altered regarding the fiber spacing and the number of stacked layers resulting in more direct-written material and, respectively, in higher drug-content per volume.