For a fixed charge small molecule force field geared towards biomolecular systems in heterogeneous condensed phase, our approach to capturing mixture interactions must be general, transferable, and focused on the LJ parameters, as charges for small molecules ligands are often generated from semi-empirical methods like AM1-BCC rather than being determined a priori. To ensure transferability, we need highquality sources of diverse data to train against. Therefore, properties of mixtures such as the densities ( ( )) and enthalpies of mixing (Δ ( )) of binary mixtures are an attractive alternative to the properties of pure systems for several reasons: