Didraction data were collected in-house using the Rigaku FRE-SuperBright. Datasets were processed by HKL3000 and initial phases were obtained by molecular replacement using apo WDR91 (PDB ID: 6VYC) as a starting model in Phaser . Model building and refinement were carried out using COOT and Refmac 57 , respectively. model building, as well as contributed to manuscript writing, editing, and final proofreading. RMC helped conceptualize this study, was involved in DEL screening experimental design, and was responsible for project oversight and manuscript writing and editing.