Using this method, 231 datasets were collected in two full-day 3D ED sessions. 113 of these datasets could be indexed using edtools without any supervision. Five phases were revealed by the HCA alongside three outlying datasets (Figure ). Based on the automated high-throughput data analyses, it was found that the major phases in the sample were GSF Form III (45 datasets, cluster 2) and GSF Form I (31 datasets, cluster 4). Crystals of GSF-PEG IC (15 datasets, cluster 1) and the new solid form (12 datasets, cluster 3) were also found. The smallest cluster (7 datasets, cluster 5) consisted of crystals of GSF Form V, and one outlying dataset was collected from a GSF Form II crystal. One of the remaining unclassified datasets was collected from an ice crystal and the other from an agglomerate. Overall, the clustering analysis revealed six phases in the melt crystallisation product, GSF Forms I, II, III and V, GSF-PEG IC and the new solid form. The unit cell parameters of all datasets are reported in Table . Out of the 118 datasets that could not be indexed initially, 22 could be indexed after XDS was re-run with manually inputted unit cell parameters of one of the six phases found (Table ). The remaining 95 datasets either showed too weak diffraction spots, no diffraction at all or were agglomerates. It is worth mentioning that although this seems like a large proportion, specific crystal morphologies were not targeted and crystals were not tested for diffraction before being added to the batch list. Instead, poorly diffracting crystals were eliminated during processing to increase the efficiency of the data collection set-up and minimize bias in crystal picking.