Table shows the numbers of the saved reactions binned into the different scoring classes ("Plus" or "Negn" with n equaling at least 0, 10, 20, or 30). We observe that the majority of products (62.6%) are in the Plus class. At the same time, the highest occupancy among the Neg classes is in the highest (i.e. worst) Neg class. This suggests that it may indeed be advisable, especially for the highly productive transforms, to limit oneself to the Plus subsets. The "Scoring Class Distribution" sheet in Supplementary Information 2 shows the scoring class distributions for each individual transform. Two of the transforms, Kabbe Synthesis of 4-Chromanones (ID 2296) and Benzazepin-2-ones by Pictet-Spengler Reaction (ID 2630) generated 10,000 or more products, but none in the Plus class.