LANaPDB totally overlaps with COCONUT. Interestingly, the overlap of LANaPDB with COCONUT is mostly in a well-defined area (left side of the TMAP), which shows that COCONUT covers a huge area (right side of the TMAP) of the chemical space not covered by LANaPDB. It is important to consider that COCONUT has more than 400,000 compounds and LANaPDB 13,578. In Figure , it is appreciated that the approved drugs are distributed across the chemical space, overlapping LANaPDB and COCONUT in different regions.