We are therefore proposing an extension of the Structured Product Labeling (SPL) standard to chemical reactions ("Reaction SPL"). SPL is based on the Health Level 7 (HL7) Reference Information Model (RIM) . One may ask, why is an information model coming from the health field being used for reactions? The reason is that information in the health field encompasses a very broad range of types of documents, data types, and degrees of formalized vs. free-text descriptions. SPL as a fairly light and robust XML document standard uses a highly generic data schema, and has seen use cases such as people, organizations, products, and devices; science and measurements, including complex data, waveforms, and imaging; missing data and uncertainty; workflows, protocols, and processes; and scale from geography down to organization, building, devices, substances, and molecules and their parts. To a good extent, chemical substance-type data, such as substance indexing SPL files published in NLM DailyMed , are therefore a subset of the world that HL7 describes. This concept is extended here to reactions and reactionrelated data since reactions in the real world often have annotations that go beyond chemistry-type data.