It is worth briefly comparing HiPRGen to template-based methods of reaction enumeration. HiPRGen is inherently inefficient compared to template-based CRN generation. Many of the reactions generated by HiPRGen may not occur in a single step, may not be kinetically accessible (due to excessively high energy barriers), or may not ever occur in the chemical system of interest because they require a reactant that will never form. While we are continuing to improve HiPRGen's filters in order to better avoid non-elementary or inaccessible reactions, in the absence of a general method to robustly identify plausible species and reactions in electrochemistry, this inefficiency cannot presently be avoided. Templates can also produce unreasonable reactions, and it can be difficult even for experts to identify such exceptions to chemical rules. Nonetheless, this problem is likely more severe for filterbased than template-based reactions. Where HiPRGen excels is in the inclusion of exceptional reactions that do not follow normal trends or patterns. Moreover, HiPRGen's method of bucketing ensures that no duplicate reactions will ever be added to a CRN (a particular reactant-product pair is only considered once), while in a naive template-based approach, duplicate reactions could easily be produced if multiple templates convert a set of reactants to the same products.