> 500 A visual comparison of the centroids of the top 100 compounds for each target for AHC in combination with DF2 and REINVENT is shown in Figure . With disregard to prior knowledge of target ligands and suitability of the scoring function, the quality of chemistry generated is again indistinguishable between the two RL strategies. However, regarding cocrystal ligands and known important residue interactions, the scoring function is not always suitable as shown in the case of AGTR1. Here we can see no acid moieties are generated for AGTR1 by either strategy (Figure ) which will be in part due to the docking algorithm targeting only the Y35 1x39 sub-pocket and out towards the extracellular surface (Figure )