For this test case, the relative protein-ligand interaction energies are shown in Fig. relative to the conformer with the largest interaction energy. The conventional MFCC scheme already reproduces the energy pattern rather well, with only small misorder on conformers 6 and 1. The MFCC-MBE(2) scheme has a small misorder at conformer 6 but can recreate the energy order very well. Also the MFCC-MBE(2) scheme does not only get the order right, but it is also closer to the supermolecular results, while the MFCC scheme overshoots especially at the last three conformers 2, 3, and 10.