From the 11 drug-target interactions tested, five showed an experimental readout greater than 25% drug-target interaction at 30 µM, and were selected for further in vitro characterization (Table ). Four out of five drug-target interactions were confirmed by further in vitro evaluation. IC50 and Ki or Kd values in the nanomolar range (baricitinib and tofacitinib on PKN2) and in the micromolar range (baricitinib on Phosphodiesterase 10A2