This study shows how the universal and quantitative detection capabilities of (q)NMR, by itself or in combination with countercurrent pre-separation, provide an advanced foundation for concurrent targeted and untargeted DS adulteration assays. Demonstrated for two "curcumin"containing DSs that compromised the liver functions of several consumers in 2019, the approach is fit for recognizing adulteration of non-natural natural product ingredients (here: synthetic 1) in the presence of analytically confounding factors such as multi-vitamin and piperine fortification.