A new study presents a new approach to detecting heavy metals in water by using a printed paper-based origami electrochemical sensor. The results of the study showed that the origami device was able to filter debris from dirty water and detect parts per billion levels of lead and cadmium ions in buffer solution. The proposed device was compared to commercially available screen-printed ceramic electrochemical sensors, and the results showed that the paper-based origami electrochemical sensor device was suitable for detecting heavy metals in water samples. The study demonstrated the potential of the paper-based origami electrochemical sensor device to effectively filter out debris before the sample reaches the sensor for testing. The applications of the device could be extended to the fields of environmental monitoring, medical health, and food safety. Future work will entail testing of heavy metals on the 3D origami devices, and optimizing the detection results for Cd+2 ions. Overall, the study presents a promising solution for detecting heavy metals in water using a low-cost and disposable paper-based origami electrochemical sensor.