In an illustrative example where hit matter shares an indole as the common scaffold, EVPs of exemplified compounds containing the indole scaffold in ChEMBL can be analyzed to assist the sampling of various patterns when establishing SAR. Using a relatively large dataset of 3,635 readily available indole derivatives extracted from ChEMBL (see Methods and Models for information about this dataset), we demonstrate that EVPs can be incorporated into a mathematical model to enable the systematic sampling of diverse EVPs in an approximately uniform fashion.