PROTACs as the baseline model and removed duplicates. For the ratio of compound whose total score is higher than 0.8, the "No RL" procedure is roughly 0.51, which is lower than that of other RL procedures. If we look into the ratio of Vina docking score (ie. ratio for ADV score < -10.9, which is the docking score of reference PROTAC), a component of the total score, the difference is more significant. For PROTACs generated from the "No RL" procedure, its ratio is about 0.35, while that of other RL procedures are above 0.54. Similar trend was observed for the ratio of 𝑃 𝑠 > 0.9. This result shows that the RL approach can generated more desirable solutions than sampling from prior model alone without running RL. Some example BTK PROTAC compounds and their potential docking conformations were illustrated in Figure .