Dithianes are commonly used in organic chemistry to mask the electrophilic nature of carbonyl groups in elaborated molecules but also serve as acyl anions in syntheses according to the Umpolung concept. The main advantages of dithianes are their easy access from a carbonyl compound by using propane-1,3dithiol and a Lewis acid and their stabilities in alkaline and acid conditions notably permitting their purification on silica columns. In counterparts to this stability, many procedures have been developed for their deprotection but generally require drastic conditions. Most of the time, toxic metal salts as Hg(II), Ag(I), Zn(II), Ga(III), Cu(II), Tl(V) and others are used in excess in harsh conditions with some success. The use of hypervalent-iodine reagents for the removal of dithianes has been also reported as an efficient process using periodic acid, diacetoxyiodobenzene, bis(trifluoroacetoxy)iodo-benzene (BTI), Dess-Martin periodinane and N-halosuccinimides. However, a large variety of the aforementioned methods require the use of toxic metals, the need of oxidizing species in large amounts sometimes accompanied with co-oxidants mainly in harsh reaction conditions. In this context, we believe that an alternative milder process is still needed using for example inexpensive and soft reagents to achieve this transformation at room temperature in the presence of various functional groups.