To find key targets in Alzheimer's disease (AD) we used Open Target Platform v23.02 (release 22 February 2023) . We search all targets related to AD under the Experimental Factor Ontology (EFO): MONDO_0004975 and/or Medical Subject Headings (MeSH): D000544 terms. Then, the Associated Targets option in the Open Target Platform was used to map all AD associated targets. Next, with the AD targets identified, we proceeded to search for all compounds with reported biological activity in the ChEMBL database (v32).