The prediction of Raman and specifically ROA spectroscopic fingerprints of disordered oligopeptides represents a great challenge to current computational approaches, because they are very sensitive not only to the secondary-structure conformation of the backbone, but also to the solvation structure and the side-chain conformations. with respect to the experimental spectrum remain. In particular, the calculations predict prominent peaks at about 1600 cm -1 and 1300 cm -1 , which are absent in the experiment.