data available in our database. Therefore, it is better appreciated how the behavior of the experimental lipophilicity profiles fits more closely when evaluated using Eq. 2, particularly at extreme pH values. Additionally, at pH 7.4, the influence of apparent ionic partitioning can be observed depending on the chemical nature of the molecule. For instance, Debrisoquine in Figure represents a base with a very high pKa. Hence, ionic species were more abundant at pH 7. Although the distribution coefficient in solvent systems represents only a mimetic for many biological and physicochemical processes, its relevance and successful application in several life sciences fields is undeniable. In this regard, we further investigated the repercussions of the apparent ionic partition of molecules in the applied parameters and metrics where lipophilicity is relevant.