Paggi et al. built the ComBind pose selection pipeline on the hypothesis that distinct ligands bind to the same receptor in similar ways. However, we show in Figure that the Open-ComBind objective function does not always select ligand poses that are the lowest RMSD to the ground truth. All of the proteins tested show a lower full objective function value when evaluating on the lowest RMSD near-native poses sampled by gnina in comparison to the objective function value when selecting from all sampled poses. However, we do see that our inspection of the underlying hypothesis agrees with the ablation studies in that the usage of only the hydrophobic contacts similarity and RMSD of MCSS improves the objective function's performance in selecting near-native poses. Further, we see that use of only the RMSD of MCSS is able to find poses with the same objective function value as the lowest RMSD to ground truth poses. This implies that the RMSD of MCSS featurization aligns well with the underlying hypothesis, while the other features do not. It is likely that the hydrogen bonds, salt bridges, and hydrophobic contacts of the lowest RMSD to ground truth poses do not show as great of a consensus due to side chain rearrangement during binding of different ligands. Therefore, allowing side chain rearrangement during docking would likely improve the performance of Open-ComBind pose selection.