Especially for a cut-off value of two, the ratio of connected strategic molecules shows substantial benefit. This becomes less noticeable when allowing more steps. The reason for this is the so-called small-world phenomena. The NOC shows that on average each pair of nodes can be connected in six steps. Thus, differences are most noted in very small screening ranges. Considering a cut-off value of three, we find all strategic molecules connected and 57% of the molecules in random sets being connected. This experiment strongly indicates the importance of strategic molecules as they are better connected to the exemplary feedstock.