The richness of MOFs chemical and structural properties have stimulated the development of plethora of MOF-based SERS detection platforms. As revealed in our dataset, so far there are 38 different MOFs serving for detecting of 103 analytes. Approximately 30 percent of the detected analytes are dyes and this prevalence can be attributed to the necessity of analysis industrial dyes in watercourses 100 and also to their common use as benchmarking compounds for Enhancement Factor evaluation (see below). While the complete dataset has been made available, Table presents select examples, illustrating the use of MOFs for SERS measurements with and without (plasmonic) metallic nanostructure component. MOF versatility extends to pore chemistry, accessibility, and flexibility, emphasizing their potential in VOC detection. Combining MOFs with SERS substrates offers a promising path for advancing VOC detection, as showcased in Table , highlighting the varied applications of these systems. Maximizing SERS signal strength for sensitive analysis of target analytes requires adjusting of instrumental parameters of the reader and design of the substrate, as well as taking into account parameters related to the analyte itself. Different figures of merit were established for quantification of SERS performance utilized in different platforms. and the so-called Enhancement Factor (EF) is commonly used for comparing the output signal provided by the SERS substrate to regular Raman scattering: