In general, QED and SAscore values for alvaBuilder molecules were alike or better than the reference database (ChEMBL´s DNMT1 inhibitors). Designed molecules from FooDB and UNPD-A exhibit decreased values of both scores, possibly because of the higher molecular complexity of food chemicals and natural products compared to small molecules of synthetic origin. Means from LigBuilder molecules were below the reference database for both QED and SAscore. These relative values could be associated with the penalty of molecular complexity and inherent synthetic feasibility problems related to de novo design .