In order to justify the use of HetPCM, we next compute solvation energies using different dielectric setups and compare HetPCM results to Voronoi-PEqS values, as the Voronoi construction of ε(r) best maps onto the concept of "different dielectric constants for different atoms". We use ε solv = 78.4 for all of these calculations but vary ε nonp . Results are provided in Tables 4 for ε nonp = 1 and 2, and in Table for ε nonp = 4 and 10.