As described in Materials and Methods, the interactions of this set of metabolites with proteins of Homo sapiens and bacterial species belonging to a set of genuses typical in intestinal microbiome samples were retrieved from ChEMBL, BindingDB, and literature searches. A total of 2139 interactions were identified, comprising 507 targets and 426 metabolites. This results in ratios of 0.32 interactions per metabolite, 0.076 targets per metabolite, and 6.4% of metabolites with at least one interaction described (of all the 6663 metabolites). There are almost 10-fold interactions more with human proteins than with bacterial ones (1942 vs 197, respectively), corresponding to 451 human targets vs 56 bacterial ones, and 405 vs 128 metabolites interacting with human vs bacterial proteins (note 451 + 128 > 426 as some compounds interact with both human and bacterial proteins). The distributions of compounds per target and targets per compound display typical long right tails. The target with the largest number of compounds (80) is aldehyde dehydrogenase 1A1, an oxidoreductase displaying a wide range of chemotypes as ligands, followed by the thyrotropin receptor (60), and prelamin-A/C (52 compounds). The compound with the largest number of interacting proteins (89) is luteolin, a flavonoid, followed by apigenin (86), another flavonoid. In both cases these compounds interact with a wide range of protein classes, including kinases, oxidoreductases, and proteases.