The largest scaffold diversities are observed in the "Other", "7TM1", "Oxidoreductase" and "Hydrolase" target classes. These are target classes that bind multiple chemotypes. In the case of "7TM1", they are known to interact with organoheterocyclic metabolites like indole derivatives, plus short-and long-chain fatty acids, fatty amides, hydroxycarboxylic acids, bile acids, benzenoids, etc. On the other hand, the "Other" class is by definition quite variable as it contains multiple protein families, so as expected it has the highest scaffold diversity. In turn, "Oxidoreductase" contains proteins quite different like cyclooxygenases, monoamine oxidases, lipoxygenases, etc., and these are targeted by diverse chemical families such as prenol lipids, flavonoids, etc.; while the "Hydrolase" target class include a wide range of inhibitors and substrates as well (e.g. flavonoids, xanthine derivatives, etc.) that interact with very different redox enzymes: cholinesterases, phospholipases, endonucleases, etc. This is in contrast with other target classes, where the number of unique scaffolds is much more reduced: e.g. in "Nuclear receptor" proteins are targeted mainly by molecules in the "Steroids and steroid derivatives"; or that have just few compounds in the gut metabolite set: "VGIC", "LGIC", "7TM2", "7TM3", "Ligase", etc.