In the selection of the compound collection investigated here, we had not taken nSPS or molecular weight into consideration. We now assume that a selection of PNPs with higher molecular weight and/or nSPS from Enamine or other collections can lead to a higher rate in CPA. However, we are aware that such a strategy may oppose the often favored prioritization of lead-like compounds (with MW<400) for screening campaigns to enable robust hit-to-lead optimization.