To assess the drug-likeness of the VHL binders, parameters of one physicochemical property, i.e. lipophilicity at physiological pH (logD7.4), and one pharmacokinetic property, i.e. plasma protein binding (PPB), are provided in Table . Both were experimentally obtained employing HPLC-based protocols. Expectedly, the introduction of two chloro substituents resulted in the most lipophilic compounds (13 and 17), whereas the replacement of naphthalene by quinoline (22 versus 23) reduced lipophilicity.