There is a substantial contribution from ~65 million vendor-linked CIDs and, crucially from the prior-art aspect, ~23 million from automated patent extractions (largely from SureChEMBL and IBM) along with a smaller set from manual patent SAR extraction by BindingDB. The consequence is that, while this (free) coverage of exemplified compounds cannot be considered as complete, we could expect few chemical series from the global medicinal chemistry output to be without any similarity coverage in PubChem (see 'Managing expectations: assessment of chemistry databases generated by automated extraction of chemical structures from patents', 2015, PMID 26457120 but note that coverage and patent indexing in PubChem has increased significantly since this paper). Ipso facto searches with ADEV lead series has become essential and should be consolidated with substructure and superstructure searches.