Insight: This question focused on the ability for LMMs to find a specific complex with a "JEDI-852" His241 substitution referenced several times along with other JEDI complexes located in the middle of a complex document. ScholarGPT correctly answered this question from text. Both 3.5 Sonnet and ChatGPT 4o answered similarly. From Huseby, D., et al. PNAS 2024, 15065 words. Table ScholarGPT 9.5/10 Response to Prompt 09 for Accurate Document Retrieval JEDI-852 was identified as the largest outlier regarding interactions with the enzyme due to its structural differences compared to other inhibitors. Specifically, JEDI-852 lacks the aromatic ring 1, which allows its piperazine ring to make a small re-orientation in ring 2, thereby optimizing its interaction with the enzyme. This structural variation impacts the conformation and binding dynamics of JEDI-852, making it distinct from other inhibitors.