For fully orthogonal photoswitching at least two different two-state photoswitches need to be addressable by four different light signals (all-photon), resulting in very strong enrichment of each of the resulting four combined states. Further, the sequence of light signals as well as the particular starting state for irradiation should not have an influence on the final state composition (path-independent). Additionally, each of the final states should represent a stable photostationary isomer composition such that there is no need for timing the duration of irradiation. This specific set of conditions for truly orthogonal photoswitching systems represents of course the best possible performance description and consequentially there is almost no precedent fulfilling every aspect. Two notable advancements in this regard are early reports on a molecular logic system based on diarylethenes and spiropyrane and a DNA-based molecular device using two differently substituted azobenzenes. However, both examples need to include several UV light signals of different wavelengths in order to establish allphoton orthogonal behavior, which is problematic due to the destructive high energy content of UV irradiation.