In the field of cyclodextrins, Sinaÿ and co-workers reported an iteroselective O-debenzylation of perbenzylated cyclodextrins with DIBAL-H (diisobutylaluminium hydride). Large excess of DIBAL-H (30-120 equiv.) under mild or harsher conditions led to the mono-and di-O-debenzylations of perbenzylated α-cyclodextrin bearing 18 benzyl ethers in 64% and 82% yield, respectively (Figure ). In both cases the ite corresponds to the yield (64% and 82%) because the large excess of reagent should lead to the exclusive per-O-debenzylation under a normal distribution. The selectivity was rationalized by the limited number of bulky DIBAL groups allowed on the cyclodextrin narrow rim, thus leading a maximum of two debenzylations at distant positions, thus achieving both itero-and regioselectivity. Sollogoub and co-workers later employed the mono-O-debenzylation to achieve an impressive multistep hetero-hexa-functionalization of α-cyclodextrin that required high itero-and regioselectivities over each step (Figure ). 24