We used the four ML models, trained using the BR1 descriptors, to predict the interlayer distances of all 1431 possible bilayers (Table ). Clearly the mean and standard deviation of the interspacing distance are the same for all models. The smallest minimum d is predicted by the RVM model (1.753 Å). The SVM gives the most accurate prediction for pristine bilayers (2.0%), followed by RF (2.9%). there is a significant trend in size from S < Se < Te, while the metals have similar vdW radii.