The six POC/solvent pairs that met the solubility threshold (200 mg + 1 mL) above were screened for methane uptake using 1 H NMR spectroscopy and compared to the neat solvents (Figure ). Full experimental details are presented in Supplementary InformaVon SecVon S6. On addiVon of CH4 into the 2-methylphenol sample, the POC precipitated with the condensed CH4 behaving as an anV-solvent, meaning the uptake could not be determined. For the remaining five soluVons, measured CH4 uptakes suggested that four new type II PLs had been formed with 2-ethylphenol, 2-phenyl-1-propanol, 1phenylethanol, and 2-methyl-1-phenyl-2-propanol, which all showed significant uptake enhancement compared to the neat solvents, albeit to varying degrees (3.3 to 8.1 Vmes, Figure ). This success indicates the model is effecVve at size-exclusivity predicVon. Furthermore, while CH4 uptake was recorded in the diphenyl ether cage soluVon (5.7 µmol mL -1 ), no direct comparison is made to its neat solvent counterpart as it forms a solid at ambient condiVons, and therefore it cannot be determined whether a porous liquid has formed. Thus, we are also unable to use this solvent in the size-exclusivity validaVon.