The sensitivity heat maps of dissociative adsorption of oxygen shown in Figure has a reversed trend compared to the physisorption of CH 4 . The chemical process proceeds more rapidly due to 1% increase in oxygen adsorption rate on metals with strong carbon bonds ( E C < 7 eV) and weak oxygen bonds ( E O > 4 eV). This acceleration facilitates enhanced oxygen adsorption on the surface fostering the further reactions. The negative sensitivities appear only on the metals with strong oxygen bonds and low carbon bonds (bottom right corner) which have very low values in the descriptor screening maps in Figure , indicating that it is one of the reactions limiting the chemical process on these metals, because the coverage of oxygen is too high.