Co-evolutions were then attempted using diacyl glycerol (dga) as the parent to target one of the lipid-surface shallow-grooves at the crystallographic 1k4c homotetramer model (Figure , red spheres). However, although hundreds of raw-children could be generated, the DW-BEL program shortly stopped without predicting any fitted-children. Results were similar despite testing many alternative criteria combinations (Table , homotetramer lipid cavity). Apparently the dga head defined a limited cavity to allow for DW-BEL selection of any fitted-children. Because one cavity was sine-qua-non requirement for DW-BEL co-evolution, one hypothetical 1k4c homoctamer could be a possible alternative. Therefore, one 1k4c hypothetical homoctamer forming a PyMol visible cavity for dga was constructed using their supplied crystallographic symmetry coordinates (Figure , down-right cartoon). In contrast to the homotetramer, DW-BEL from the dga parent targeting the homoctamer-dga complex, generated 52824 random-rawchildren, of which 3891 (~ 7 %) were predicted as non-toxic fitted-children (Table , raw-and NTNV-children). These non-toxic fitted-children predicted exceptionally high correlations between DW-BEL and ADV affinity estimations, most of them at higher affinities than its dga parent (Figure , red circles vs green circle). For instance, the top-child number 34511 predicted ~ 0.05 nM affinity, compared to ~ 30 µM of its dga parent (Figure , red circles vs green circle) and was the most representative scaffold among the top-children (96 %, n=100) including additions and alternative atoms, bonds / bond types and/or rings / ring numbers. To note that all these non-toxic fitted-children targeted similar homoctamer hypothetical lipid cavities, despite the many other possibilities offered by the wider 45x45x45 Å grid which included 2 center cavities among many other possibilities (Supporting Materials / 100top-children.lipidcavity.pse). Ten topchildren data were listed in Table to visualize some of their properties. Additionally, 100 children data were supplied as DW Tables provided with sliders including DW-BEL and ADV affinities, molecular weight and hydrophobic properties (Supporting Materials / 100top-children.lipidcavity.dwar).