The raw data files were processed with the publicly available workflow on TDPortal (, Code Set 4.0.0) that performed mass inference, searched a database of human proteoforms derived from Swiss-Prot (June 2020) with curated histones, and estimated conservative, context-dependent 1% FDR at the protein, isoform, and proteoform levels. Each tissue type was searched separately with its own FDR context. Aggregated search results were used in further data analysis.