In particular, thousands of abaucin-children predicting higher affinities to their docking-cavity could be generated by targeting the alphafold modeled A.baumannii LolCE cavity. These large number of abaucin-children allowed to study an example of how undesirable docking predictions, for instance those against any commensal species, could be used to minimize antibiotic off-target effects. To retrieve a similar large number of candidates would have been impossible using more traditional screening, even if targeting the largest chemical libraries publically available (Mcule, chemSpace, Zinc, PubChem, Chembl, etc). Nevertheless, enormous number of alternatives still exist to be explored in the vast chemical/chemotype space .