To decode the mechanism of loss of crystallinity of ZIF-8 due to electron beam irradiation, we first need to understand the structure of ZIF-8 crystal itself. The fundamental building block of ZIF-8 comprises a single zinc atom linked with four imidazolate units, forming a tetrahedral structure. This arrangement, characterized by N-Zn bonds and N-Zn-N angles, embodies a composite framework integrating organic and inorganic components. The N-Zn bond is considered the weakest in ZIF-8 structure , which has a bond dissociation enthalpy of 353 kJmol . Utilizing the flexible ZnN4 tetrahedra, a conceptual model featuring two fully adaptable gates emerges, including a 4membered ring (4MR) and a 6-membered ring (6MR). Notably, the 6MR gate, with an aperture size of 3.4 Å, acts as the primary entry point for guest molecules, facilitating their transfer between adjacent cavities . The 6MR gate or aperture size is represented by {431} Bragg plane.