An illustrative example of the activation of adjacent positions in the carbon chain by an electron-accepting nitrile group is observed in the synthesis of β-sultam 29. This process involves the reaction of sulfonamide 30 with bromoacetonitrile 31 (Scheme 1). Initially, the Nalkylation of the sulfonamide takes place in the presence of K2CO3 in DMF, resulting in the formation of intermediate compound 32, which can be isolated from the reaction mixture. Subsequently, deprotonation of the α-methylene unit in 32 occurs, and the resulting carbanion acts as a nucleophile, leading to the replacement of bromine and the subsequent formation of 29. Scheme 1. Alkylation of allyl sulfonamide with bromoacetonitrile 31 followed by intramolecular nucleophilic substitution for the synthesis of β-sultam 29