The ETS (erythroblast transformation specific) domain is denoted by ETS(IPR000418). This domain is rich in aromatic and positively charged residues and forms a binding affinity for purine-rich DNA segments. Various members of the Ets family of proteins exhibit different DNA binding specificities. The Ets domain and flanking amino acid sequences influence a protein's binding affinity, and modifications to a single amino acid in the Ets domain can modify its DNA binding specificity.