In conclusion, in this study we successfully designed, synthesized, and characterized the first photochemically targeting chimeras (PHOTACs) for the targeted degradation of histone deacetylase 6 (HDAC6). By incorporating an azobenzene photoswitch into our previously developed HDAC6-selective PROTAC A6, we created PHOTAC 12, which exhibited significant HDAC6 degradation only upon activation to its cis-state by irradiation with light of 390 nm. Invitro ternary complex dimerization assay indicated that the cis-isomer of PHOTAC 12 results in significant increase in ternary complex formed, consistent with potent degradation of HDAC6. These findings establish PHOTAC 12 as a promising lead for the development of lightactivatable HDAC6 degraders, highlighting the potential of PHOTACs for the precise spatiotemporal control in targeted protein degradation.