While this approach has achieved significant success, it faces two main limitations. First, designing the guessed product structure heavily relies on chemical intuition, which may not always yield realistic predictions. To mitigate this, various methods have been developed to explore the potential energy surface (PES). Many of these techniques leverage the local curvature of the PES to identify the minimum energy pathway connecting reactants, transition states, and products . These methods have proven effective but are generally restricted to small, lowcomplexity systems where complex dynamic effects can be neglected.