Both silver compounds showed high activity across the spectrum with MICs ranging from 6-98 nM. Unfortunately, they also showed cytotoxicity, with CC50 values in the low micromolar range (Table in SI). Nevertheless, due to the more potent levels of antifungal activity resulting in a comparatively good therapeutic index of 33,333, Ag2 is still considered a promising hit compound for further testing. The free ligands of Ag1 and Ag2 showed no activity in the CO-ADD primary screening (Table in SI). At first glance it seems that the nature of the ligand is less important as both Ag1 and Ag2 show very similar biological properties. However, a third silver complex from the same collaborator with a very similar ligand showed significantly lower antifungal activity (Ag-S4 in the SI).