Solvents can interact with proteins and other biomolecules through dipole-dipole, electrostatic, van der Waals, hydrogen bonding, and hydrophobic interactions . Solute-solvent interactions, in particular the protein hydration, are of fundamental importance for the stability of folded structures . Understanding solvation can be complex due to the heterogeneous nature of the biomolecular surfaces, the presence of cosolvents (such as osmolytes), the intricacies of tertiary structures, and the various types of interactions that the solvent or cosolvent may establish with the proteins . In this context, Ionic liquids (ILs), composed mainly of organic cations and organic or inorganic anions , have gained significant attention due to their ability to establish a wide range of interactions with biomolecules . The unique solvation properties of ILs originate from the asymmetry and charge delocalization of the ions, and possible presence of nonpolar groups, such as aliphatic side chains .