For example, thermodynamic models that exclude mass and heat transfer effects cannot be used to predict productivity and simple metrics such as working capacity may fail to indicate the right material and process. Other studies have shown that metrics beyond material and process design, such as capital and OPEX (their evaluation requires a TEA of the process) and climate change (its evaluation requires a life cycle assessment (LCA) over the entire supply chain), may lead to different conclusions on the suitability of a material and/or a process. There are currently limited studies that go beyond material metrics and explore the synergies between thousands of materials and different process designs with the help of a computer (#6).