In this work, we focused on hydrogen and oxygen evolution reactions. Some descriptors are specific for these reactions (band-edge alignment), and some descriptors need to be fulfilled for any photocatalytic reaction (suitable band gap, low spatial overlap of electron and hole, and low charge-carrier effective masses). Therefore, for other redox reactions, only models for band-edge alignment should be fine-tuned accordingly, and our results for the three general criteria still hold. We showed that there is an area in the chemical design space of MOFs where these three general criteria are met. This area can be enriched by focusing on designing materials with suitable charge-carrier effective masses and band gaps, given that the spatial overlap criterion is more widely met.