The virtual Chemoinformatics and Artificial Intelligence Colloquium, Mexico City , June 15-17, 2022, provided an overview of the current developments, specific applications, and areas of opportunity in the application of AI, ML, and DL methods to the discovery and design of bioactive molecules. The perspective was provided by speakers at different career levels working in different research environments worldwide. During the colloquium, the role of chemists, chemoinformaticians, and data scientists in accelerating drug discovery and development, which regularly takes 10-15 years, was discussed.