The ideal synthesis of structurally diverse dendrimers should be robust and simple with respect to purification of the intermediates and final products and it should be scalable allowing preparation of multigram amounts if necessary. A convergent synthesis of PAMAM-dendrimers based on the coupling of structurally diverse dendrons to a core requires cores having up to four orthogonally addressable groups (figure ). The present methodology is based on the previously reported convergent synthesis of all-symmetrical PAMAM-dendrimers . The methodology allows not only synthesis of PAMAM-dendrimers with a number of different surface groups but also analogs to the PAMAM-dendrimers built from different types of AB2-units (figures 2 -5). The t-butyl esters are cleaved under acidic conditions, the benzyl esters by catalytic hydrogenation, the heptyl ester as an example of adding lipophilicity and potentially enzymatically cleavable and the methyl ester can be cleaved with nucleophiles or displaced by aminolysis. The cores were synthesized as shown in Schemes 1 and 2.