We observed that for highly-constrained problems, e.g. the design of HOIPs, the most effective strategies were risk-averse, such as FCA-0.8. Contrastively, for slightly-constrained problems, e.g. the design of BCR-Abl inhibitors, we observed that less risk-averse strategies tended to locate promising objective most efficiently, such as naïve-ignore and FCA-0.2. However, these strategies were not among the most effective approaches to avoid constraint violations.