A mixture of bromide (1 equiv), boronic acid or boronic ester (1.2-2 equiv), and K2CO3 (2 equiv) in a mixture of dioxane and water (1.0-2.0 M) was degassed, followed by addition of Pd(PPh3)4 (0.05-0.1 equiv). The reaction mixture was heated to 85 ℃ and stirred overnight. After completion of the reaction, the mixture was cooled to r.t., diluted with EtOAc and water. The organic layer was washed with brine and concentrated in vacuo. The crude residue was purified by preparative HPLC (10-100% MeOH in H2O + 0.05% TFA) to give the title compounds.