1.72 9 in combination with eqn. 1, we derive a value of KIE195 = 1.783. Regardless of this relatively modest variation between the various predicted values of KIE195 = 1.922, 1.63 9 or 1.783, these values are all substantially lower than the measured KIE195 of 2.82± 0.07, an observation that propagated into the article title 3 as a significant deviation from transition state theory.