Several plant or medicinal herbs have been identified and harnessed for treating diseases due to their potent phytochemical constituents . In this study, we aimed at identifying small molecule inhibitors present in Lingonberry (Vaccinium vitis-idaea L) against PDE6D which is in complex with KRAS. Lingonberry (Vaccinium vitis-idaea L), found mostly across Central Europe, Russia, and Canada, is a shrub identified as a good source of phenolic compounds with promising therapeutic potentials . McDougall et al. showed that extracts from berries including Lingonberry have antiproliferative effect on cervical and colon cancer cells. Recently, Zhu et al. showed that Lingonberry extracts could inhibit the proliferation of hepatoma cells (HepG2). Thus, we combined structural bioinformatics and molecular modelling approaches in ligand-protein interaction analysis for developing potential drug candidates for KRAS-mutation lung cancer.