Recently, experimental data on solubility in scCO 2 for two drugs, Teriflunomide and Rifampin, were published, covering a temperature range of 308 to 338 K and pressures from 120 to 300 bar. These data were selected for external model validation. Notably, Rifampin was absent from the training dataset, while Teriflunomide was included but only at pressures up to 270 bar within the same temperature range. As a result, data points at all temperatures at 300 bar were chosen for model validation.