The antibacterial activity of cellulose can be improved using inorganic-based antimicrobial agents . Antibacterial agents made of silver, including silver sulfadiazine (SSD), is often utilized. The preparation of BC/SSD involved ultrasonically impregnating SSD into the BC membrane . Significant antibacterial activity was demonstrated by the BC/SSD membrane against many microorganisms, including P. aeruginosa, E. coli, and S. aureus .