A novel procedure for quantifying the impact of lateral interactions on the thermophysical properties of adsorbates is presented. The procedure includes four different models to parameterize the contribution of coverage dependence on the enthalpy, entropy, and heat capacity of adsorbates. It was observed that, of the four different models, the polynomial model was superior to the others in that it results in a smooth function that nonetheless captures the non-linear response of enthalpy and entropy to surface crowding. These new coverage-dependent functions were tested on two systems: CO/Pt(111) and CO/Co(0001). A two-slope trend was observed for coverage-dependent adsorption energy. Our analysis implies this two-step coverage effect is a result of a transition from solely indirect adsorbate-metal interaction and surface relaxation effect for the lower coverages to combined indirect and direct adsorbate-adsorbate interactions for the higher coverages. The change in vibrational entropy as a function of coverage was rationalized in terms of changes to low-frequency modes. Depending upon the specific adsorbate, its binding energy, and its preferred binding site, the vibrational entropy can either increase or decrease with increasing coverage at lower coverages, but at higher coverages, the increase in repulsive interactions leads to a net reduction in entropy. The impact of coverage on enthalpy was more significant than the impact of coverage on entropy. Using basic thermodynamic arguments, we conclude that coverage-dependent entropic effects are confined to a narrow temperature regime. These coverage-dependent models are now available in Cantera. The resulting microkinetic mechanisms are thermodynamically consistent.