Variable length MD Fig. shows a comparison between a typical simulation with τ const = 8 ps and one using variable MD time. The 8 ps simulations were chosen as they were most similar to the variable approach in terms of the number of candidates found, path selection probabilities and evolution of species counts (see Supporting Information for a full study of different τ const values). For the constant approach the maximum shared reactive cycle reached by the three best performing cells was ∼ 650. For the variable approach, this reactive cycle was ∼ 1200.