Initially, we compare A-optimal, D-optimal, and LOMAP designs generated with fixed 𝑛 and 𝑘 for each ligand set. The value of 𝑘 that we use for each design is the number of edges in the LOMAP design. We find that the distribution of leverages, 𝐻 𝑖𝑖 , of D-optimal designs is more peaked than A-optimal designs in all tested ligand sets (Fig. ). Note that