and reaction solvents (PMI = 3.0). In terms of the former two, the mechanochemical route greatly surpasses the benchmarking solution approaches, in which excess reactants and the use of bulk solvents substantially increase the PMI. Furthermore, the mechanochemical protocol relies on the use of eco-friendly solvents for work-up (water) and as LAG additives (ethyl acetate and dimethyl isosorbide). This contrasts with the larger portfolio of solvents involved in the solution-based preparations as that includes several toxic compounds (DMF, CH2Cl2, and chloroform). It is also worth noting that the room temperature operation is an additional benefit of mechanochemistry, in contrast to the solution methods, which rely on thermal activation and involve heating up to 140 °C.