An alternative to such approach is to apply electron density localizations at the respective atomic sites as the measure of reactivity, specifically for the protonation reactions considered. According to Liu (2014) , the Hirshfeld charge can determine regioselectivity. As the Hirshfeld charge is derived from the Conservation of Information Principle, which requires that atomic identity be maintained as much as possible in molecules. So, this charge can reflect the electronegativity or the electropositivity nature of atoms. Therefore, the regioselectivity can be evaluated by using Hirshfeld charges .