In view of dapsone is a famous bio-active molecule with the corresponding structure, we used the corresponding raw materials, through the standard explored conditions, to achieve the synthesis of this drug in large scale up to 74% yield successfully (Figure ). Motivated by this result, we also realized the synthesis of 5-HT6 receptor antagonist precursor (Figure ). Used 8-chloro-3-iodoquinoline and sodium benzenesulphinate as the corresponding substrate, under the template conditions, and 42% yield of 5b was isolated successfully which could be further converted to RVT-101 16a or Lu AE60157 16b in virtue of mature C-N coupling method 17 . What's more, considering that the numbers of cycles from stabilization were the key to measuring the practical application towards heterogeneous catalysts, we have studied the effect of g-CN though repeated to use. As shown in Figure , after each single reaction cycle, an excellent conversion rate was obtained in spit of 5 times under the same conditions and recovered g-CN still representing a thin layer appearance with TEM image attached. In summary, a dual Ni/photocatalytic C(sp 2 )-SO2Ar coupling was developed using a carbon nitride semiconductor as recyclable photocatalyst with low toxicity. The semi-heterogeneous nickel/carbon nitride catalysis is an inexpensive, sustainable alternative to homogeneous protocols. The method selectively couples a broad range of aryl bromides with sodium benzenesulfonate in good to excellent isolated yields. Dapsone synthesis was also demonstrated on a gram scale and cyclic experiments also demonstrated the great potential of g-CN in such reactions.