To understand the potential of the proposed in-situ electrochemical pH control method using interdigitated electrodes, finite element analysis simulations (COMSOL Multiphysics) were conducted to assess the generation and diffusion of protons from a protonator IDE. The simulation model was used to identify the optimal electrode arrangement for pH control and to define the necessary conditions for customizing the desired local pH levels. By applying a galvanostatic current to a protonator array, a flux of protons is produced. Fig. presents a 2-D cross-sectional view of an area measuring 260 × 300 µm, bisecting through an interdigitated array, and illustrates the pH around the electrodes after a current of 540 nA was applied for a duration of 0.01 s. It can be observed that, while the overall pH values in the bulk remain at its initial value (pH 7.0 in this case), the pH near the electrodes starts to decrease from pH 7.0 to around pH 6.4 as indicated by the color change. This is clearly evident in the magnified inset, which show a zoomed in 5 × 5 µm region around the electrodes. Fig. shows the local pH environment after applying the current bias for 2 s. The thickness of the diffusion layer has significantly increased, and the local conditions surrounding the array has decreased to a pH of 5.5 (as shown in the inset). This simulation study indicates that the local pH of the sensing electrodes can be efficiently controlled within 2 s by applying an anodic current to a protonator electrode array. This facile pH adjustment enables the achievement of the optimal pH for glucose sensing and eliminates any false positives or negatives arising from variations in the initial bulk pH. Also, as mentioned above the by-product of molecular oxygen near the sensor interdigitated electrodes, could also potentially improve a sensor's performance.