In summary, a novel strategy for achieving efficient CP-EL is proposed based on CISS effect for the first time. Initially, robust chiral near-ultraviolet ((S)-/(R)-PCNCP) and deep-blue ((S)-/(R)-PCNTPA) materials with wide energy gaps are explored, which provide highly efficient near-ultraviolet and deep-blue CP-EL with good |gEL| values of up to 3.76 × 10 -3 and outstanding ηext,maxs of 6.1% @ 396 nm and 7.3% @ 434 nm. Then, efficient green spin-OLEDs with excellent ηext,maxs reaching 31.5 % and |gEL| values around 1.00 × 10 -3 are obtained by aligning the chiral deep-blue (S)-PCNTPA layer to the achiral green layer. It is rationalized that these new chiral materials have prominent CISS effect, and spin-polarized charge carriers are generated when the current traverses through these chiral deep-blue layer, which get recombined to yield spin-polarized excitons in achiral green layer, resulting in green CP-EL. The presence of spin-polarized charge carriers is validated by the changes in gEL values at different current densities and by the chirality flip via modulating the chirality and thickness of the chiral layers. Finally, the CISS effect and spinpolarized charge carriers are further demonstrated in more complex three-emitting-layer and four-emitting-layer spin-WOLEDs by incorporating multiple achiral sky-blue, orange and red layers with chiral near-ultraviolet or deep-blue layers. The spin-polarized charge carriers generated from chiral layers can form spin-polarized excitons in achiral sky-blue, green and red layers simultaneously, leading to sky-blue, green and red CP-EL emissions. In consequence, highly efficient spin-WOLEDs are realized, providing strong circularly polarized white light with outstanding ηext,max of 26.6%, |gEL| of 5.50 × 10 -3 and CRI of 94, much superior to the performances of circularly polarized WOLEDs in the literature. These results prove the applicability and feasibility of the proposed approach for realizing efficient white CP-EL based on CISS effect from a single organic chiral layer, paving a novel and effective avenue towards OLEDs with high-quality circularly polarized white light.