the 6 position largely preserved it . This result is broadly consistent with our present observation that per-substitution at 3 eliminates binding, while derivatization at 6 leaves it largely unchanged. Although there is no guarantee that similar results will be observed for other guests or CD substituents, we have observed similar results with other guests as well (unpublished results). Thus, we suggest that efforts aimed at boosting the affinity of CDs for various guests will be more productive if they avoid modifying the 3 hydroxyl site.