The resulting functionalized PEO derivatives contain an α-acyloxy ether linkage that is susceptible to hydrolysis, leading to the generation of fragmented PEO and the regeneration of a carboxylic acid (Scheme 4). Given PEO's extensive use in biomedical applications, its facile degradation and quick excretion from the body are highly desirable. Additionally, the modified PEO can serve as a delivery vehicle for hydrophobic carboxylic acid-based drug molecules.