Contrary to downhill sampling, WTMetaD can begin from any point on the PES without prior knowledge of the TS geometry, making it applicable to a wider range of scenarios. For WTMetaD simulations in the AL process, energy barriers between minima are overcome by depositing Gaussians on the PES, resulting in a bias potential as indicated by the light blue regions in the middle panel of Fig. . These biases are introduced along collective variables (CVs), such as the lengths of breaking and forming bonds specific to the reaction.