Data in Table has been grouped based on the analyte phase. In the case of gas-phase detection of VOCs, both linear ranges and LOD values are more than suitable for detecting the target analytes in concentrations relevant for daily exposure, as determined by the NIOSH recommended exposure limit, a time-weighted-average occupation exposure limit either for up to 10 h/day or a 40-h workweek. When NIOSH-Rel values were not available, other indicators were considered, as indicated in the table. The same holds for liquid-phase detection of analytes. Please note here that concentration in such instances is expressed as micro-or nanomolar and not in terms of ppm as in gas-phase cases. The use of various MOFs, such as MIL-100 (Fe), ZIF-8, MIL-125 (Ti), UiO-66, HKUST-1, Cu-TCPP, MIL-101 (Cr), and NU-901, combined with different plasmonic nanostructures, demonstrates the possibility of generic analysis of a wide range of analytes (please note the data presented in Table are selected examples from our dataset). The linear ranges, limit of detection values, and relevant concentrations vary depending on the specific combination of MOF, metal, and analyte. An interesting point comes forth when analyzing the data in Table where no metal is present, as in the case of acetone, chloroform, isopropanol, and toluene for gasphase detection. In all these cases, it can be seen that the chemical enhancement mechanism provided by the MOF was sufficient to develop SERS substrates capable of detecting the VOCs at concentrations far below those stipulated by regulatory bodies (NIOSH values in this case). This suggests that by further investigating the interactions between MOFs and plasmonic components, it may be possible to develop SERS substrates that surpass the performance of currently used conventional sensing platforms. The presented data for gas-and liquid-phase VOC detection using MOF-based SERS substrates underscores the versatility and potential of these materials for practical applications.