The ZIF-8 particles were drop-casted on a Cu TEM grid with holey amorphous carbon support. The heating experiment was performed in a ThermoFisher Titan microscope operated at 300 kV using a Gatan INCONEL heating holder. The sample was heated from room temperature to 125°C at 1°C per second and maintained at that temperature for 1 hour. Afterward, the diffraction series was acquired. The sample was then cooled back to room temperature (RT), and another diffraction series was acquired. The dose rate and exposure time were kept constant throughout both experiments at 1 e -Å -2 s -1 and 1 sec, respectively.