The CuAAC reactions were performed by adapting reported protocols , in the presence of CuSO4 as catalyst and sodium ascorbate as reducing agent. Nucleobase propargyl derivatives 15-18 were reacted with azides 9 and 10 (Scheme 6), affording the click products 19-22 and 23-26 in low yield (19-48% and 17-30% range, correspondingly). The quantities of isolated products were satisfactory for a first antiparasitic activity and cytotoxicity screening.