We first investigated the copolymerization of POT-CF3, which is supposed to lead to less homogeneous copolymerizations with the two selected comonomers than the pristine POT. Indeed, for styrene, the kp/ktr ratio of POT-CF3 is lower than that of POT, which corresponds to random incorporation (rPOT = 0.878; rS = 0.838). The kp/ktr values are 3.61 for POT and 1.74 for POT-CF3 with styrene. Secondly, we also anticipated poor random incorporation of POT-CF3 into isobornyl acrylate chains. The kp/ktr ratio is considerably lower than that of unmodified POT, which already exhibits some compositional drift (rPOT = 1.4 and rIBA = 0.3). Specifically, the kp/ktr values are 3.24 for POT and 0.42 for POT-CF3 with acrylate. Reactivity ratios were experimentally determined by fitting the feed ratio evolution against overall molar conversion using the Skeist equation and a nonlinear least squares method (Meyer-Lowry method).