We begin by using our small test set to test DLPNO-CCSD(T 1 ) with CPS extrapolations. We compare the BHs and REs calculated with CPS (5,6) and CPS (6,7) to standard TightPNO, and then use the three sets of values to benchmark a selection of DFAs to see how the reference level of theory impacts the perceived performance of the tested methods. Based on these results, we repeat our analysis on the entire ENZYMES22 set, and while the improvements of the CPS(6,7) extrapolation and new (T 1 ) triples correction are relatively small for Figure : Schemes of the enzymatically catalyzed reaction steps used to test CPS extrapolations in this study-the test set includes the reaction energies of all steps, as well as the forward and reverse barriers of 4-OT and HKMT. The models of 4-OT, HKMT, AspDC and HheC have been taken from the ENZYMES28 set (see ref. 19 for specific details of each model system), while CDO, Hc and NiSOD have been taken from our MME55 set. these models, we present the final DLPNO-CCSD(T 1 )/CPS(6,7)/CBS (3,4) REs and BHs as updated reference values for the set.