The five endpoints that were activated by the extracts included, the TF and NR endpoints for the pregnane X receptor (PXR/PXRE), the TF and NR endpoints for the peroxisome proliferator activated receptor  (PPAR/PPRE), and the only endpoint for the nuclear factor erythroid 2related factor 2 (NRF2) (Figure , Tables ). The dose-response relationship of PXRE appeared to follow a bell shape, being more stimulatory at lower concentrations than at higher concentrations of the extract (Figure , Table ). The dose response of PPRE and NRF2 appeared sigmoidal within the range of concentrations tested (Figure Non-targeted GC×GC analyses.