Along this line, Ross and co-workers 24 adapted the NCMC scheme through implementation of a Monte Carlo osmostat added to MC simulations that can sample from a semigrandcanonical isobaric isothermal ensemble in which the number of NaCl salt pairs (that we will called later an electrolyte unit for generalization) varies to study ion distribution in water around biomolecules. The NCMC moves enable high acceptance rates for which water molecules are alchemically transformed into a pair of salt ion (i.e. an electrolyte unit) or vice-versa.