In standard transferable force fields, the torsional component is typically parameterized using QM dihedral energy scans, with the difference between analogous MM and QM energy scans minimized by fitting the torsional parameters. Reparameterization of the torsional terms has been shown to be a crucial step in improving the accuracy of force fields and this has recently been demonstrated for AMBER ff15ipq, CHARMM36 and OPLS-AA/M. Bond and angle reparameterization has also been shown to be an essential stage in improving the accuracy of biomolecular force fields, 2,36 although it is not so frequently carried out.