Preliminary snapshot PK studies were executed at Pharmaron as previously described. Male CD-1 mice (6-8 weeks, 20-30 grams) were dosed with a test compound via intraperitoneal (IP) or oral (PO) administration. A single dose of the compound (10 mg/kg) was administered to two mice as a 1 mg/mL solution in NMP/solutol/PEG-400/normal saline (v/v/v/v, 10:5:30:55). Mice had free access to food and water throughout the study. Blood (0.03 mL) was collected from the dorsal metatarsal vein at 0.5, 1, 3, and 5 h time points. Blood from each sample was transferred into a plastic microcentrifuge tube containing EDTA-K2 and then centrifuged at 4000 g for 5 min at 4 °C to separate and collect plasma. Samples were preserved at -75 °C prior to analysis. Compound concentration in the plasma samples was determined using a Prominence LC-30AD, AB Sciex Triple Quan 5500 LC-MS/MS instrument fitted with a YMC-Triart C18 column (3 µm, 2.1 x 33 mm), eluting with a mobile phase of 5-95% acetonitrile in water with 0.1% formic acid. PK parameters were calculated from the mean plasma concentration versus time and a noncompartmental model that relied on WinNonlin 8.3 (Phoenix).