Apart from the issues highlighted in this study, we consider synthetic accessibility (Gao and Coley 2020) as a major challenge for practical adaption, as even the best in silico scores remain fruitless if the suggested compounds cannot be synthesized. Generative models that respect synthesis rules could even be more robust against the overfitting problem that we elaborated on in this work. Overall, considerations regarding synthesis efforts should receive more attention, as costly designs interfere with reduction to practice in the lab.