Enzymes developed using directed evolution, such as those in the cytochrome p450 family, now facilitate reactions that were previously unavailable or otherwise practiced with less efficiency, enantioselectivity, or yield . Flavin-dependent halogenases such as RebH have been evolved to halogenate an array of small molecules with high site-specificity . Notably, a few well-placed mutations can provoke dramatic changes in both enzyme substrate specificity and the reaction catalyzed (e.g., hydroxylation vs. dealkylation). Thus, significant precedent exists for engineering enzymes toward novel biocatalyzed reactions. There are nevertheless many un-and under explored biocatalyzed reactions.