Using the ChEMBL Application Programming Interface (API), we retrieved all compounds from ChEMBL 33 (updated June 2023) associated with 13 viral targets linked to respiratory diseases. Molecular structures of these compounds were encoded in Simplified Molecular Input Line Entry System (SMILES) format. A specific acronym was assigned to each virus with a target of interest, based on its strain, ensuring consistent and accurate identification throughout the analysis. Table lists the names and Target IDs for each of the 13 targets. For compounds with multiple recorded biological activity values ("standard value") against a target, we ranked these values from smallest to largest to ensure consistency in the data. The pIC50 was calculated for each compound, and compounds were classified according to the following criteria: a) IC50 ≤ 10 μM: were labeled as "Inhibitor" b) 10 μM < IC50 < 20 μM: were labeled as "Unknown" c) IC50 ≥ 20 μM: were labeled as "No_Activity"