The distribution of scores of Molecule 48:32/CYP 3A4 is useful in gauging how it binds both in value and conformationally to CYP 3A4. This distribution is in Figure . The highest score of 86.55 is an isolated point and the number of ligand conformationally bound states is far greater near the value of 79. Due to the seeming discontinuous nature of the distribution, following from a conformational change in the set it isn't clear if the actual binding is in fact greater to Mpro than to CYP 3A4. However, the drastic drop in number of available states after 79 shows a difficulty in rotational degrees of freedom at the interaction level.