The Mpro amino acid residues involved from the 8146 docked ligands with total score ≥ 97 are listed next. These are counted using column Only ASN 142 and GLU 166 are major components in both non-covalent and covalent binding, and GLY 143 present in ~10% in the latter. This difference could be due to the spatial closeness of the covalently bound ligand to Mpro.