Analyses were performed on a Waters Acquity H class ultra-performance liquid chromatography (UPLC) system comprised of a quaternary solvent manager and a sample manager-FTN coupled to a Xevo TQ-S mass spectrometer equipped with an electrospray ionization (ESI) source (Waters, Milford, MA). LC-MS/MS data were collected and processed with Waters MassLynx v4.1 software.