Herein, we have built on our SC detection methodology to enable detection in e-cigarette liquid and directly from sealed e-cigarettes. This advance is timely, given the apparent prevalence of SC e-cigarettes being sold as 'THC'. That is, this implementation of our technology has an immediate application in both tracking the occurrence of SC e-cigarettes and providing harm reduction information. We have demonstrated that this technology is amply capable of detecting the low published range of SC concentrations found in e-cigarettes. Given we did not find a single false negative from our sample set in Figure , there is ample potential for tuning the detection limit, with a trade-off between sensitivity and specificity as with all technologies of this type.