The electrochemical paper platform presented here relies on the combination of wicking channels and electronic signal traces. The intertwined patterns of these two components are embedded in a sheet of cellulose paper and together create functional electrofluidic layers. The fabrication process is as follows (Fig. ). First, paper-embedded electrodes are generated via laser-induced pyrolysis, harnessing the high carbon content of cellulose to create graphenic conductive traces in situ. Next, fluidic channels are formed by laminating wax onto the cellulose. It is noteworthy that the patterns for electrodes and channels are fully independent, enabling the fabrication of individually isolated and superimposed regions, with full control over wetting and conductive properties (Fig. ). Remarkably, the process is scalable; per A4 sheet of cellulose paper, we can fabricate up to 176 sensors within 90 minutes at a cost of under $0.02 per sensor at a prototyping scale (Fig. and Table ).