Because of this, high doses are required for oral administration, which causes adverse side effects in the gastrointestinal tract. The doped SPIONs were produced by flame spray pyrolysis (FSP), a bottom-up nanomanufacturing technique with proven scalability and reproducibility. The structural, morphological, magnetic and heating properties of the FSP-made SPIONs were characterized and their cytotoxicity on human Caco-2 intestinal cells assessed. A Design of Experiments (DoE) approach was applied to systematically investigate the effects of nanoparticle and tablet composition, and AMF exposure time on the degree of drug amorphization in the tablets.