Neuroblastoma can be treated through surgery, chemotherapy, immunotherapy, radiation therapy, and bone marrow transplants . PROTAC, which stands for Proteolysis Targeting Chimera, induces the ubiquitination degradation of target proteins . It has two active domains connected by a linker, and the domains connect with E3 Ligase, in the case of a neuroblastoma the Bromodomain and Extra-Terminal (BET) proteins, which is important for cell functioning and gene regulation . Its malfunctioning can lead to the uncontrollably replication of cells, which can mutate and result in neuroblastoma. The ubiquitin on the E3 Ligase transfers to the BET and marks it for destruction .