Organofluorine compounds have found broad application in medicines and polymers owing to the unique attributes that fluorine atom endows the target molecule, such as absorbability, lipophilicity, binding selectivity, metabolic stability, corrosion resistance, and et. al. 1 Among various fluorine-containing scaffolds, gem-difluoroalkene is very important and valuable, serving as the core skeleton in a number of pharmacologically and agromedically active molecules (Scheme 1A). 2 By replacing a carbonyl group in a specific molecule with a gem-difluoroalkene group, improved bioactivity, metabolic stability, and target specificity are often achieved for the carbonyl congeners, such as artemisinin and arabinose derivative. 3 Moreover, difluoroalkenes could also function as versatile building blocks in the preparation of numerous fluorinated molecules. 4 Consequently, it's of high activity for the development of mild and efficient approaches to the gem-difluoroalkene scaffold in the research area of both organic chemists and pharmaceutical scientists.