It is important to acknowledge that while 3D COFs offer remarkable internal surface areas and pore sizes when compared to their 2D counterparts, the latter have received more attention as potential functional materials for small-scale swimmers. This trace can be attributed to both the fact that synthesizing 2D COFs is relatively easier when compared to 3D COFs, as well as to the lack of synthetic approaches that can achieve a controlled generation of 3D COFs with nanoscale sizes. Nonetheless, limitations such as large particle size and the dependence on light propulsion hinder a broader use of the reported 2D COF-based microswimmers in the human body. Additionally, challenges arise from 2D COF synthesis in organic solvents or via solvothermal methods, posing integration difficulties with other small-scale devices and compatibility issues with other biomaterials.