This step is memory-intensive but generally completes quickly. Finally, the SPIB module can finish in a few minutes for a single ∆t. As previously mentioned, the final SPIB latent space definition is transferable between homologs with similar tertiary structures because the input features are transferable. For example, we found that the latent space is fully transferable between DDR1, Abl1, and Src kinases. This transferability could further improve the efficiency of the protocol when working with multiple proteins within the same family.