The number and type of chemical structures relevant to drug discovery and other related applications are increasing dramatically. Similarly, the number and kind of experimental or calculated descriptors also augment. The continued increase in the number of compounds and descriptors encourages novel ways to interact with the chemical space beyond the traditional medicinally relevant chemical space built based on drug-or lead-like properties of the pharmaceutical interest and the conventional organic small-molecules. Herein, we introduce the concept of the chemical multiverse as a group of chemical spaces, each one defined by a given set of descriptors. A "chemical megaverse" is the collection of chemical multiverses, and this would be provided by the several different groups of descriptors that can be used to define a chemical space. Same as the chemical space concept itself, the chemical multiverse and chemical megaverse have applications in several research areas, including drug discovery and beyond. Similarly, the chemical multiverse can be the subject of quantitative and qualitative analysis and exploration. A next step to further developing the concept is to illustrate chemical multiverses using compound data sets with different chemical nature and different representations. The work is in progress, and the results will be made public soon.