In a review of different EDAs targeted at drug discovery, 108 the SAPT0(B3LYP) method was included as the sole representative of the entire SAPT formalism. The present comparison demonstrates that this approach is a poor substitute even for conventional HF-based SAPT0, even if the δHF correction were included. In the larger aug-cc-pVTZ basis set, the reason is obvious: significant overestimation of dispersiondominated interaction energies. This is a net result of a second-order perturbation theory formalism that overestimates dispersion, combined with a functional that lacks correct asymptotic behavior and affords smaller HOMO/LUMO gap as compared to HF theory. Within a perturbative formulation of E disp , smaller gaps manifest as dispersion energies that are too attractive. GGA functionals narrow the even further as compared to global hybrids like B3LYP, with correspondingly worse results within SAPT0(KS), as documented in Fig. . Functionals that lack correct asymptotic behavior should not be used in SAPT0(KS) calculations.