ACE2 is a type I membrane protein widely expressed in nasal goblet secretory cells, lung type II pneumocytes, ileal absorptive enterocytes, among other host cells , and participates in the maturation of angiotensin, a peptide hormone that controls blood pressure and vasoconstriction . After virus entry, many severe ill COVID-19 patients developed clinical manifestations such as cough, mild fever, dyspnea, lung edema, severe hypoxemia, acute respiratory distress syndrome (ARDS) , acute lung injury , interstitial pneumonia, increased concentrations of fibrinogen and D-dimer plasma levels , elevated levels of pro-inflammatory chemokines and cytokines such as interleukin (IL) 6 , low levels of type I and III interferons (IFNs) , high levels of lactate dehydrogenase, hyperferritinemia, idiopathic thrombocytopenic purpura caused by spleen atrophy , formation of hyaline membrane , hilar lymph node necrosis, lymphopenia , intravascular coagulopathy , pulmonary thromboembolism , cerebrovascular events , severe metabolic acidosis, kidney and hepatic dysfunctions , secondary infections, septic shock and multi-organ failure .