Two compounds, 5a and 5b, were chosen for their favorable interaction patterns and scores predicted by docking simulations. 5a combines the N10 hydroxypropyl fragment of 2e, benzyl in place of the PABA phenyl of 3a, the tail amide of reference compound 1g, and, for 5b, in addition, the tail pyrrolidine of reference 1h replaces the tail piperidine. The activities and predicted interactions in all parasite targets are most similar to 2e, suggesting the key importance of the hydroxy-propyl substituent to N10 for the target inhibition. Notably, while 5a ). . indicates that a precise activity value could not be determined as the tight binding limit was approached. In the bottom panel, selectivity indices are reported. (B) The structures of the selected and synthesized pteridines in the merged series.