Symmetry breaking also creates the universe and life. Though molecules can take both "left-handed" and "right-handed" forms, life originates from left-handed amino acids and living organisms predominately use right-handed sugars. For macroscopic materials, the diversity of their properties possibly originates from symmetry breaking, including antiferromagnets, ferroelectrics, liquid crystals, etc. Therefore, symmetry breaking has important implications for the origins of life, scientific research, as well as understanding and manipulating the properties and applications of materials. The method of studying phases and transitions in terms of symmetry and symmetry breaking is known as the Landau paradigm, in which aggregates are involved. Aggregate is one of the common existing forms of macroscopic materials, as anything above a single molecular specie can in principle be deemed as aggregate. It has turned out that the behavior of large and complex aggregates composed of elementary units cannot be understood in terms of simple accumulation of the properties of these particles. That is, the whole becomes not only more than the sum of its parts, but very different from the sum of its parts. Specifically, molecules in the gas or liquid phase exhibit a disordered arrangement, displaying single molecular properties. While in the crystal state, molecules display anisotropy with an ordered packing, leading to property transition (Scheme 1a). For example, the varied properties of water and ice are assigned to the symmetry decrease of isotropy of water molecules from the liquid state to the solid state (Scheme 1b). Besides the above-mentioned newly emerged properties of aggregates compared to their single molecular species, the subtle difference in packing mode/ assembly size/ morphology among aggregates with the same composition can also result in varied properties and functions. In this regard, aggregationinduced emission (AIE) is a symbolic and well-studied case, which refers to the photophysical behavior of organic molecules displaying weak or no emission in dilute solutions but much enhanced emission in the aggregate state (Scheme 1b). The working mechanism of AIE is proposed to be the restriction of intramolecular motion (RIM), which claims that the active excited-state intramolecular motion in the solution state facilitates the non-radiative decay and thus quenches the emission while the aggregation can restrict the excited-state intramolecular motion and thus suppress the non-radiative decay to light up the emission. Based on the investigation and deep understanding of the AIE phenomenon, research that focuses on the variations of aggregate and their composed units like molecules has attracted great attention and was coined as aggregate science. Within the research philosophy of aggregate science, varied fields including aggregation-induced generation of ROS, photothermal/photoacoustic effects in aggregate, solid-state molecular motion, aggregation-induced chirality, as well as room temperature phosphorescence in aggregate, etc. have gained wide research attention and grown as independent research fields. Nobel prize winner P. W.