This study focuses on QM9 data, therefore E min is still unproven for larger molecules or molecules with elements not found in QM9, thus further work can be done to assess E min 's generalizability as a synthesizability descriptor. When evaluating E min accuracy as a function of molecule length however, we do not see much variation in predictive performance between molecule with 6, 7, 8, or 9 heavy atoms (see ??. Thus, we hypothesize that E min should still effectively describe synthesizability for molecules with 10+ heavy atoms. While the next section includes a brief evaluation of E min on larger molecules up to 14 heavy atoms, more work should be done to fully understand its limitations for larger molecules.