) degrade those predictions. The same interactions captured in solvation free energies should also be informative for properties of pharmaceutical/biomolecular interest, such as binding affinities. For this reason, optimization of LJ parameters against mixture property targets is planned to be the standard going forward for our OpenFF force fields. It is also important to note the scope of the study is limited to LJ parameters, and that other parameters, such as electrostatics, torsions, and 1-4 atomic scalings will impact the accuracy of these mixture properties. We anticipate that the automated property prediction in our parameterization workflow, along with the wider chemistry covered by the mixture properties in the ThermoML Archive, will lead to more accurate LJ parameters for general small molecule force fields.