Thanks to the simple strategy consisting in the double masking of a naphthohydroquinone with boronate groups, we demonstrated the feasibility to design an efficient and versatile exponential molecular amplification system, wellsuited for the sensitive detection of H2O2 down to a few nM in less than 10 minutes or a redox cycling compound such as the 2-amino-3-chloro-1,4-NQ down to 50 pM in less than 30 minutes. These remarkable analytical performances are the best so far reported for an autocatalytic molecular amplification strategy, amounting to a 300-fold improvement in LOD compared to H2O2 detection by dendritic chain reaction. Such performances are the result of the high chemical stability of the diboronate ester probes (a high stability resulting from the double protection of the probe and a non-utilization of a self-immolating protective group) as well as a particularly good reactivity towards H2O2. Another important result of this work is that it demonstrates the usefulness of deciphering the mechanism and kinetics of complex reaction networks in order to better understand, predict and optimize their functioning.