SupraFit is written in C++ utilising the Qt Software Development Toolkit 1 and the Eigen Library. SupraFit is mainly developed for NMR titration and ITC experiments, providing methods to globally and locally analyse 1:1, 2:1/1:1 and 1:1/1:2 complexes out of the box. Fully statistical analysis based on Monte Carlo simulation and F-Test approaches with a good scaling on multicore systems are implemented as well as an intuitive user a Institut für Organische Chemie, Technische Universität Bergakademie Freiberg, Leipziger Strasse 29, Freiberg, Germany. E-mail: Conrad.Huebler@gmx.net † Electronic Supplementary Information (ESI) available: Selected images with higher resolution (Fig. ). Input data for simulated 1:1/1:2 model. Selected images with higher resolution (Fig. ). Calculated intersection in Mole Ratio plot (Table ). Selected images with higher resolution (Fig. ). Representation of boxplots from Monte Carlo simulation for NMR titration (Fig. ). Comparison of initial guessed and least-squared estimated parameters in ITC experiments (Table ). Isotherms and dilution experiments (Fig. ). Estimated parameters and confidence interval with different dilution strategies (Table -S5, Fig. ).