The hydrothermal-vent interface of early submarine vent systems has long been proposed as a hatchery for the emergence of early bioenergetic processes. This model is based on the mechanism of chemiosmosis, or vectorial electrochemistry, which describes an energy conversion mechanism, universal in known modern cells. In that cell mechanism, exergonic and endergonic processes are coupled using natural electrochemical gradients, resulting from the pH and redox gradients, as drivers to chemical reactions, mediated by membrane-located molecular machines, or enzymes. This energy conversion system is considered as universal and antique as the genetic code in known living systems. In a model of early cell metabolism, a key step for emergence includes the reduction of the oceanic CO2 by serpentinization-derived H2 mediated by vent minerals, in a prebiotic analogy to the reductive acetyl Coenzyme A (also known as Wood-Ljunghdahl pathway; WL). From this context, we investigate the first steps for the emergence of key metabolism for life. We focus here on models of prebiotic pathways based on the Wood-Ljungdahl (WL) pathway and on the reverse tricarboxylic acid (rTCA) cycle. Both are considered key protometabolism for the early phases of biochemical evolution involving Acetyl-CoA an highlyreactive and energy-rich molecule. In environments with alkaline vents, this model for the emergence of bioenergetics offers pH and electrochemical gradients as driving forces for proto-biological processes, facilitated by the interface between hydrothermal fluids and the primitive ocean (which we will refer to as early vent-ocean interface). Vent efflux of moderate temperature (~70ºC), moderate reducing potential and alkalinity (pH ~9), juxtaposed with the cold, acidic oceanic fluids, percolate a labyrinth of micropores in the mineral precipitate (predominantly formed by carbonates) that mediate the interface. The mechanism of catalysis proposed is by minerals composed of iron and sulfur (Fe-S minerals) or iron oxyhydroxides (green rusts)-both plausible on early Earth in the context of hydrothermal vents. Clusters of Fe-S and iron oxides are considered precursors of important enzymes for carbon transduction and fixation processes, such as the case of the WL pathway.