In an effort to maximize the number of compounds that could be purchased, we removed compounds that cost >$75 for the smallest sample, had delivery time >21 days, or came from vendors providing fewer than six compounds in our list. After filtering, we took the union of the remaining top 600 compounds from the RF-C model and the top 600 from the Similarity Baseline model. We ordered the 1,028 unique compounds in the union that were still available for purchase from AMS. When evaluating the hit rate for the RF-C and Similarity Baseline models, we considered not only their top 600 ranked predictions after filtering but rather all compounds we ordered that were in their original top 1,500 ranked compounds. For example, the compound ranked 73 by the RF-C and 986 by the Similarity