Mukaiyama (using organomagnesium and organolithium reagents) and Oguni (using organozinc reagents) showed that optically active alcohols could be prepared when chiral amine and amino alcohol additives were included in the reaction mixture. As Wynberg put it, "it does not take a great leap of the imagination" to consider extensions to synthesis of chiral amino alcohols in reactions catalyzed (perhaps self-catalyzed?) by chiral amino alcohols. It is especially worth noting that the second author on the Mukaiyama paper was one Kenso Soai. A decade later, organozinc chemistry had been extensively developed, the concept of nonlinear effects in asymmetric catalysis had been introduced by Kagan, and asymmetric amplification had also been demonstrated in the diethylzinc alkylation of benzaldehyde using chiral amino alcohols. The observation of nonlinear effects leading to asymmetric amplification in catalysis hints at a Franktype chiral amplification as well as an inhibition mechanism that is key to the model for the emergence of homochirality, which might in fact be considered as the ultimate nonlinear effect.