[ To produce degradable polymer prodrug nanoparticles, rROPISA was then carried out in presence of LMA, BMDO (f BMDO,0 = 0.66) and increasing amount of PtxMA (f PtxMA,0 = 0.016-0.10), under the same experimental conditions (PT2-5, Table ). Overall, relatively high conversions in LMA were obtained (59-68%), with no clear tendency in terms of M n or dispersity. Interestingly, by adjusting the initial stoichiometry, it was possible to finely tune the amount of Ptx in the copolymer as the drug loading linearly increased with f PtxMA,0 from 3 to 33 wt %, while F BMDO ranged from 9 to 16 mol % with no clear trend (Table ). Switching from BMDO to MPDL did not affect F PtxMA but gave higher F CKA (PT6).