Furthermore, the average length of protein sequences varies greatly -for instance considering the 566 amino acids of HIV-1 RNaseH-RT and the 2549 amino acids of the human mammalian target of rapamycin (MTOR) -and could influence the sensitivity significantly and hence the ability of PCM to detect signal from the averaged representation used herein. To remedy these challenges, the use of alignment-dependant or autocorrelation descriptors could be explored . Moreover, as previously mentioned, some mutants are disease-causing and are often the drug target. For these cases, in which molecules are optimised away from the WT, the baseline for the QSAR-WT could be substituted with the disease-causing mutant.