The last two terms are treated at the MM level and are therefore trivial to calculate with the corresponding force-field equations. In standard QM/MM calculations, the first term is calculated directly by determining the electronic energy in the presence of MM point charges, but this is not possible when using a MLP (in which electrons are not represented). EMLE aims to recover this first term without relying on an electronic description, by predicting the difference of the total energy of the QM (or MLP) subsystem in vacuo and in the presence of MM point charges: