Converting bulk water into micron-sized droplets renders it to behave unusually, often facilitating the chemical transformation of species dissolved in it. The recent surge in such water microdroplet chemistry has been enriched by various studies, which include observations of accelerated reaction rates, the promotion of unusual chemical reactions, and the stabilization of highly reactive intermediates at the air-water interface. The cause of such multifaceted chemistry, preferably at the air-water interface of microdroplets, is often attributed to a multitude of variables that the reactant species experiences at different extents depending upon the nature of the reactant. Some of the important variables driving the water microdroplet chemistry have been identified to be: i) high intrinsic electric fields (up to 10 9 V/m) at the droplet surface, ii) orientation of reactant(s) at the droplet surface, iii) partial solvation of reactant(s) at the air-water interface, iv) droplet surface polarity or pH (acidity/basicity), v) confinement of reactants/reagents in small volumes, vi) evaporation of droplet and thereby sizes and associated lifetimes. Besides the preceding factors, impurities like ozone or other reactive oxygen species at the microdroplet interface have been suggested to influence the interfacial chemistry in microdroplets. The origin of these impurities and reactive oxygen species, including H2O2, remains a topic of intense debate. Studies by Mishra and co-workers found no role of interfacial electric fields (IEF) in the formation of H2O2. Instead, they suggested the origins of H₂O₂ in water microdroplets is closely linked to the use of ultrasonic humidifiers, ambient ozone or dissolved oxygen. Zare and co-workers later affirmed that H2O2 can be formed in microdroplets in the absence of ozone, however, the quantity of H2O2 drops by two orders of magnititude. Besides, Colussi proposed that HO•, consequently H2O2, are formed when partially hydrated HO -and H + ions at the surface of colliding charged microdroplets undergo exothermic electron transfer. The Head-Gordon group provided theoretical supports to the role of electric field, partial solvation, and charges in microdroplet H2O2 chemistry. Several theoretical and computational works have shown the presence of large IEFs at the air-water interface localized to a region of several Angstroms at the surface. If these fields exist in real microdroplets, do they actually play a role in catalytic reactions? Furthermore, it remains unclear if the role of IEFs depend on the specific type of chemical reaction being studied. The current study aims to investigate and clarify the impact of the multiple factors, including specifically IEFs, potentially affecting the catalysis at or nearby to the water microdroplets surface where we focus on a typical Diels-Alder (DA) reaction.