The alkylation step was carried out in a similar setup as described for the aforementioned amidation reactions. The feed solutions of 4, 5, triethylamine (TEA) and 6 were prepared in ethanol. The solubility of 4 was increased by adding 1.1 equiv TEA to the stock solution. The reactor coil was switched to a 2.79 mL perfluoroalkoxy alkane (PFA) coil and the BPR was set to 18 bar. During the dynamic experiments for the alkylation step, the concentration of 4 was varied between 0.3 and 0.5 M and the temperature was varied between 60 and 120 °C. The loading of 5 and TEA was varied between 1.0 -2.0 and 1.35 -2.0 equivalents, respectively. The residence time ramps were between 1 and 10 minutes.