Advances in molecular design offer promising strategies for controlling molecular conformations in nanoscale junctions. Molecules exhibiting a junction conformationindependent conductance could overcome the limitations associated with precise control over nanogap dimensions and conformational variability. Ladder-type molecules feature an uninterrupted sequence of rings with two or more shared atoms between adjacent rings , which provides unique structural characteristics beneficial to molecular electronics . Ladder molecules exhibit a shape-persistent architecture that reduces the conformational degrees of freedom of molecular backbones . From this view, we hypothesized that ladder-type molecules would exhibit a nanogap-independent conductance in single-molecule junctions-a trait seldom observed in conformationally flexible scaffolds . In addition, the increased coplanarity in ladder-type molecules promotes delocalization of the frontier orbitals across the molecule , facilitating efficient end-to-end charge transport along the backbone.