In this review, we have examined the phenomenon of Friedel oscillations from three perspectives: physical, chemical, and computational. The physical perspective offers a robust theoretical framework for analyzing Friedel oscillations' origin, properties, and peculiarities in various abstract setups, beginning with J. Friedel's seminal work in 1958. The chemical perspective encompasses numerous systems that facilitate experimental studies of Friedel oscillations, such as through Scanning Tunneling Microscopy (STM) imaging. We have also shown that FOs dictate the reactivity of systems that feature electron delocalization. The computational perspective employs the most contemporary methodologies, requiring both physical and chemical perspectives to verify computational results and avoid artifacts while also providing tools for predicting the behavior of complex systems. This constitutes a challenge in itself.