Constant pH MD simulations are not the only type of simulation that are difficult to set up. Over the years, several tools have been developed to aid in setting up MD simulations: CHARMM-GUI is a web environment that allows the user to generate input files of a wide range of biomolecular systems for various simulation approaches, PACKMOL can generate structures of complex biomolecular systems, and BioSimSpace 34 is a Python framework that allows setting up and running simulations with different software engines. Several tools were also developed to automate preparation steps for free energy simulations. Such tools simplify the setup process by automating the time consuming and error-prone generation of simulation input files. However, there is currently no such tool to automatically set up constant pH simulations for GROMACS.