Modeling LNPs and designing new formulations present unique challenges for physics-based computational approaches due to several critical requirements. Firstly, achieving high chemical specificity and accuracy in lipid interactions, while incorporating diverse system componentssuch as solvents, ions, the target endosomal membrane lipids and LNP components, including the encapsulated cargos like nucleic acids -can be demanding. Secondly, accurately simulating the spatial and temporal scales necessary for LNP behavior and drug delivery poses significant computational challenges. The complexity of these systems requires extensive computational resources to model interactions over long timescales and large spatial domains. Additionally, capturing the conformational flexibility of molecules and the precise thermodynamics of LNP assembly and drug delivery is essential. Despite advances in in silico methods, many approaches struggle to fully meet these demands, including coarse-grained (CG) methods.