Although NCL is a nuclear protein; however, in contain cancer cells they moves to the surface of cancer cells and can be used as a biomarker of these cells . Using the alpha fold technique, we have elucidated the 3D structure of nucleolin bound with RNA . Since, NCL shares a complex and flexible nature getting the complete 3D structure is very difficult, and only a tiny segment of the protein has yet been elucidated. Computational-based 3D structure (elucidated by AlphaFold 2) has been reported in a review article by .