In addition, tuning the support and cluster composition simultaneously can further enhance the resistance to CO poisoning, as shown in Figure , providing the existence of joint effects between the nanoalloy and 2D surface. Every Pt5Ge5(CO)/2D system weakens the interaction with CO as compared to Pt10(CO)/2D. As seen in pure Pt, among the Pt5Ge5(CO)/2D, the strongest interaction with CO is found when the bimetallic cluster is anchored on graphene-based supports. In Pt5Ge5 deposited on silicene and 2H-MoS2, ΔGCO* are reduced up to ca. -0.6 eV and Pt5Ge5/SmSI has a ΔGCO* of only -0.20 eV. Even further, no chemisorption is observed in Pt5Ge5/germanene; CO is bounded only by physisorption. In this cluster most Pt sites have high coordination numbers with neighbouring Ge atoms, causing a repulsive interaction with CO.