Figure shows the distribution of the similarity of our molecules to the existing CheMBL 48 database. We find a low mean similarity of 0.42, which increases to 0.52 program can thus pick up ways of making synthesizable molecules without reproducing preexisting molecules. This novelty was expected given that the program has no information from CheMBL fed to it at any point, but it is worthwhile to note that no significant bias creeps in by using the SYBA model as a classifier for synthesizability. In all cases, almost no molecules have a similarity above 0.8