Current ligand-based target prediction methods assign the targets for a given small molecule based on the known targets of the most similar ligands in their training datasets, which represents a target-bias over specific protein families. Considering that chemogenomic data related to epigenetics is minimal in comparison to protein families such as kinases, G protein-coupled receptors, and ion channels , epigenetic targets are underrepresented in the currently available models. Moreover, despite the increasing relevance of these targets across several different therapeutic areas , there are no web-based tools to support epigenetic drug discovery.