TPr and 60.7% FDr. Generally, correlation thresholds are set to 0.7 and higher, which could actually lead to omitting more TPs. Although, this is likely to depend on the quality of the signal in the data as well. If there are high fluctuations in the signal, even though a smoothing technique is used, the correlation of the true fragment peaks can be lower than the generally used threshold. As for the t r difference a maximum t r difference of 0.025 was found with an 96.7% TPr and 67.6% FDr. Using these parameters and the optimized 0.005 Da CNL model with a score CN L threshold of -0.95, the performance of these methods and combinations were compared.