VOR is histone deacetylase inhibitor (HDI) and used for the treatment of skin related manifestations like cutaneous T-cell lymphoma . Like DAS, VOR also exhibited higher compatibility for hydrophilic pMeOx as compared to hydrophobic blocks. The increase in compatibility for the hydrophobic blocks was observed in following order, i.e. pBuOx > pPentOx > pPrOzi > pBuOzi (Figure ). The maximum achievable aqueous solubility of VOR was found to be 2 g/L (LC ≈ 16 wt.% and LE ≈ 100%) with A-pPentOx-A triblock copolymer while its structural isomer, A-pBuOzi-A (appearing as least efficient solubilizer by compatibility estimation) could solubilize 1.8 g/L (at 2 g/L VOR feed) (LC ≈ 15 wt.% and LE ≈ 90%) while the second structural isomer pair i.e. A-pBuOx-A/A-pPrOzi-A exhibited similar solubilizing capacity (i.e. ≈ 1.7/1.7 g/L, respectively) (LC ≈ 14 wt.% and LE ≈ 85%) (Figure ).