Unlike other machine learning (ML) technologies, the statistical models resulting from this strategy are interpretable at the molecular level. The parameters in the IFD model included the NBO charge of the hydrogen on the 𝛽-carbon from product structures, which classified whether the radical cyclization mechanism is 5-exo or not, and the NBO charge of the carbonyl oxygen, which further differentiated between ring sizes (Fig. ). The first free ligand parameter in the aMD model (the NBO charge of the 𝛽-carbon) similarly classified 5-exo cyclization. The second parameter in the aMD model (Sterimol Lsub, describes the flexibility of the substrate's alkene substituent) differentiated the resulting ring sizes in product structures. The positive coefficient accompanying the Sterimol LSub. term was associated with lower selectivity when Sterimol Lsub is large, as in 4a (Fig. ).