We used RT-TDDFT with Ehrenfest-based molecular dynamics to probe the degradation of PFAS/PFOS solvated with 43 explicit water molecules under the influence of electromagnetic radiation. Previous work by us on PFAS/PFOA has shown that 43 water molecules was sufficient to capture explicit solvent effects, which is necessary to mimic the natural solvation environment required for exploring the photo-induced dynamics of PFOA/PFOS. The use of explicit solvent in this work also provides a more accurate simulation of fluorine dissociation dynamics (and the possible formation of photo-induced reaction products) since hydrogen-bonding effects are more accurately captured by explicit solvent compared to coarse-grained polarizable continuum model approaches. The RT-TDDFT formalism with Ehrenfest-based molecular dynamics allows us to accurately capture non-adiabatic processes, such as the optically-induced, excited-state degradation dynamics examined in this work. The time-dependent orbitals were obtained by solving the self-consistent time-dependent Kohn-Sham equations: