Compared to existing AA data our residence times are potentially underestimated. Two out of three 200 ns AA (GROMOS53a6) simulations of cholesterol bound to the SMO receptor BS1 site showed partial dissociation and reorientation 84 . While this is not enough sampling to calculate an average residence time, it hints at times similar to the ~80 ns we recover for this site. AA (CHARMM27 protein model with CHARMM35 cholesterol) simulations of β2AR show residence times ranging from 100 ns up to several microseconds . In this case, Martini 3 underestimates the residence times observed. Importantly, for both proteins we still recover similarly high levels of occupancy as a result of rapid exchange events between multiple cholesterol molecules.