Other sources of error can be present and, for this specific system, we can mention the fact that BIRB796 uses a crystal structure (PDB ID: 1KV2) while all other ligands were docked using PDB ID 3NNV. In general, we find that the wrong binding pose is more likely to be connected to weaker binding and shorter residence time. In this case, we do not observe this effect and we can be confident of the generated poses. This is again another useful, albeit a posteriori, validation that is not present in techniques that rely on empirical correlations between simulation time and residence time. Cyclin Dependent Kinase 8 (CDK8)