-Getting adequate sleep is essential for brain health and has been linked to improved cognitive function and a reduced risk of cognitive decline. All these strategies are not mutually exclusive, and anti-aging research often involves a multidisciplinary approach that combines different approaches to promote healthy aging and extend lifespan. Yet, regardless of the extensive research for anti-aging therapeutics, based on the general understanding that aging is malleable in diverse species, to date no convincing evidence has been provided indicating that the administration of existing anti-aging remedies can markedly slow aging or increase longevity in humans. The major roadblocks that the anti-aging research and development is currently facing are summarized in Table .