The vial was sealed with a Teflon-lined screw cap, and running inside the glovebox at room temperature. After 1, 6, 12, 16, 20, 24 h, the vial was shipped outside of the glovebox. The reaction mixture was diluted with dichloromethane and filtered through a plug of silica gel. The crude solution was concentrated in vacuum and subjected to column chromatography 100:1 PE/EA to isolate the products Kinetic study-diastereoselectivity Table . Computed energetics for the hydro-alkylation of diene 1a with ketone 3i.