The SAXS curves of AP205 VLP in VDB at pH = 7.0 exhibit the same features as AP205 VLP in PBS, showing no significant change of the VLP under the reduced ionic strength (see Figure ). DLS of AP205 VLP in VDB showed a hydrodynamic radius of RH= 16.9 ± 0.2 nm from the Contin fit (see Figure and Figure ), also in agreement with the size obtained for the AP205 in PBS. SAXS and DLS confirm that the AP205 VLP retains its original shape in PBS and VDB under experimental conditions.