Figure . Anti-parasitic activity expressed as percentage of inhibition against T. brucei brucei for reference compounds and members of the N10-, PABA and tail-modified series (A) and the selected representatives of the merged in silico library (B). The average of at least three independent determinations is shown with the standard deviation. The inactive compounds in the tail modified series, 4f, 4h and 4j were omitted. Activities can be found in Table . Therefore, we investigated the correlations of physicochemical properties and ADMET predictors with the measured effect on T. brucei, see Table . Our aim was to identify which properties were indicative of a better anti-parasitic effect, possibly related to better uptake.