In Table we compare the timings of the RegioSQM20 method, the RegioML model, and the WLN architecture by Struble et al. 8 for the 3,050 molecules in the test set. We report the median CPU time and the mean CPU time for predicting the regioselectivity of a molecule given a SMILES representation as input. For the RegioML model and the WLN architecture, the timings cover descriptor creation as well as model prediction for all reaction sites in the given reactant.