As expected, larger values (corresponding to long-term stability measurements) are associated with negative predictions. This suggests that drug loadings of formulations with lower initial LC and LE values are also affected more by long-term storage than those corresponding to ultrahigh loading properties. Furthermore, the drug feed (DF) represents another important experimental property for all models. As expected, higher values are associated with more positive predictions for LC and more negative predictions for LE values. This conforms to the correlation shown in Figure :