Basically, by arbitrarily breaking the symmetry in this way, the problem is immediately resolved upon inspection of the digraph. We note for double spiran VS281, the result of application of the proposed Rule 6 generates the opposite descriptor to the one assigned previously. We believe this is a due to either a misassignment or a typographical error. (b) After application of Rule 6, all ligands are distinguished. The center receives a descriptor. Such will be the case only for compounds that have rings that involve the root atom and three or more ligands. A full application of Rule 6 tests all possible promotions, though this is necessary only for certain symmetries. Any matching R and S pairs are ignored; if a descriptor remains, it is valid.