The wide-open conformation observed in these YopH chimeras has previously been observed in other PTPs from different subgroups, STEP, LYP, and GLEP1 , as well as being sampled as a rare event in simulations of wild-type YopH . Further, small molecule inhibitors have successfully triggered this wide-open conformation in PTPRZ and RPTPγ , indicating the importance of understanding the relevance of this conformation for drug discovery efforts.