In this Review, we present some of the significant advances in recent studies of stimuli-responsive frameworks materials. In particular, we highlight some of the novel responses that have been discovered in the past few years, the toolbox developed by researchers in the field to better understand the materials' behavior (both experimentally and computationally), and show some of the latest progresses in the discovery of materials with targeted behavior, whether through de novo design or identification of known materials for new properties -similar to what is known in the field of drug discovery as repurposing.