To define general trends of the children targeting each of the A3 dimerinterfaces, their rank profiles were compared. Rank profile comparisons predicted ~10-100-fold less affinities (higher docking scores) of A3B, A3C, A3F,A3G, A3H and AID relative to the rank profiles from A3A and A3D (Figure ). Nevertheless, study of their corresponding top-children showed they were different for A3A and A3D. Thus the top-children NN2904, NN1317 and NN115 predicting 5.1, 6.0 and 8.5 nM affinities to A3A, predicted lower 38.9, 64.6 and 64.6 nM affinities to A3D, respectively (Figure ). Therefore, the A3A top-children mentioned above were selected to further study their amino acid interactions. The selected top-children corresponded to star-shaped 3-arm molecules containing a central benzene with one common 14-atom arm terminated with a benzene and including one pyrazolidine ring (Figure , red triangle atoms). The other two arms included several atom/ring variations and 5-atom rings (mostly azolidines).