Figure presents the most stable adsorption sites of CO on Pt10 and Pt5Ge5 complexes deposited on the rest of the 2D supports. Our goal is to assess the influence of the support on the CO adsorption properties of the Pt(Ge) clusters. Similar to the case of phosphorene, CO is also found to prefer the atop adsorption configuration, bonded to Pt. Upon adsorption, the charge accumulation on CO is similar in every cluster/2D system. Pt10 shows the greatest ΔGCO* when supported on 5-8-5-DV and gr-B (Figure ), with a ΔGCO* of ca. -2.6 eV and -2.0, respectively. This may be explained in terms of the interaction strength of these supports with Pt10. Gr-B shows the weakest interaction with Pt10, and as a result the ΔGCO* comes close to the value in gas-phase complexes (for comparison we provide the BE[CO] in Figure ). Pt10/5-8-5-DV has even a higher CO binding strength than in gas-phase, which may be ascribed to the charge deficiency of the cluster. In the rest of the supports, pure Pt presents a substantial drop in ΔGCO*. Indeed these values are similar to that of Pt5Ge5 in gas-phase. We now demonstrate another strategy to weaken the Pt-CO interaction, without the need of doping or alloying, suggesting that tailoring the support is as effective as alloying.