The preferential binding coefficient is defined as where nc(r) represents the number of cosolvents and nw(r) number of water molecules at distance r from the center of mass of neopentane or cavity, Nc is total number of cosolvents and Nw is the total number of water molecules in the system. The positive value of γ indicates preferential binding of solute with co-solvent while negative value favors solvent i.e. water near the solute.