We determined a group of consistently well-performing methods in the pK a challenge. When looking at individual error metrics, many submissions are not different from one another in a way that is statistically significant. Ranking among methods changes based on the chosen statistical metric and does not necessarily lead to strong conclusions due to confidence intervals that often overlap with one another. Here, we determined consistently well-performing methods according to two accuracy (RMSE and MAE) and two correlation metrics (Kendall's Tau and R 2 ). For ranked submissions, we identified two consistently well-performing REF00_Chemaxon_Chemicalize is a reference method that was included after the blind challenge submission deadline, and all other method names refer to blind predictions. Methods are listed out in Table and statistics calculated for all methods are available in Table . . REF00_Chemaxon_Chemicalize is a reference method that was included after the blind challenge submission deadline, and all other method names refer to blind predictions. Most methods have a statistically indistinguishable performance on ranking, however, for R 2 , two methods (EC_RISM , REF_Chemaxon_Chemicalize), tend to have a greater ranking ability than the other methods. Evaluation statistics calculated for all methods are available in Table of the Supplementary Information.