We studied the influence of the complex properties on the docking performance by assessing the RMSD of the best pose with regard to the ligand flexibility and buriedness, as well as the number of crystal contacts made with the ligand and its structural quality. Small rigid ligands show a lower median RMSD than ligands with a higher number of rotatable dihedrals (Figure ). As expected from our previous study, structures presenting a high ligand buriedness and no crystal contact resulted in a lower median RMSD value as compared to the ones with high solvent accessibility or containing at least one crystal contact (Figure and).