When the imidazole in the prodrug monomer is cleaved, then native Lenvatinib is released. In case where a co-monomer is cleaved, the prodrug monomer (Lenvatinib with imidazole) is released species, which can degrade further to eventually release the native drug, or act as a (slightly less effective) drug itself, as demonstrated above in the binding assay with VEGFR2 (see Figure ). During the controlled degradation experiment, we noted that there is a small number of particles remaining after 24 h. We therefore monitored their degradation over 2 weeks with SEM revealing that the majority of particles degrades after 2 days. Further degradation leads to film formation around day 7 before full degradation is completed around day 14 (see