In the first round, CACHE aims to secure sufficient funding to purchase and assay ~100 compounds for every qualified participant to distribute among 3 targets. In subsequent rounds, these costs will be transferred to participants. We estimate the costs of experimental testing for 100 compounds is approximately USD$25,000; this includes purchasing of the compounds, quality control, protein purification, equipment time, primary biophysical assays, and hit confirmation using orthogonal assays. To facilitate logistics as well as to provide the opportunity to negotiate bulk pricing, CACHE will procure the compounds on behalf of all participants. If participants wish to test more than 100 compounds in the first rounds, or if the number of participants exceeds the initial available funding, participants may be required to fund some portion of per-compound costs.