It is to be noted that, when a random torsional move is attempted in the halfway point of an actual NCMC move proposal, the work values are overall higher than the case we have looked at in this section since the degree of perturbation in the binding pocket is larger. 4.3. Acceptance rates and actual transitions vary with different amounts of NCMC relaxation. In previous MD/NCMC work, 8 move acceptance rates were dependent on the NCMC protocols. Hence, we decided to explore how variations in the NCMC protocol, in particular the total amount of NCMC switching steps affect the move acceptance rates (Figure ).