Most of the antifouling strategies rely on the application of coating (layer) which can act as a passive barrier by preventing a contaminant from reaching the electrode surface, or active one through releasing some neutralizing agent. Protective layers can modify the surface in such a way as to minimize interactions with potentially detrimental substances, e.g. by changing the hydrophobicity/hydrophilicity, imparting a charge, etc. Such layers can be formed from polymers, which form a physical barrier, preventing access of unwanted species. They can render the surface superhydrophobic impairing adhesion of new species. Hydrophobic and uncharged hydrogels prevent fouling not only through the barrier effect but also thanks to strong repulsive hydration forces of the bound water . Most of the approaches towards electrochemical sensors use chemical modification as an antifouling coating. A huge advantage of this approach is the wide range of polymers and end-group functionalizations, which can be easily applied on the biosensors surface. Poly(ethylene glycol) (PEG) and its derivatives (e.g. OEG) are one of the common antifouling materials widely used in biomedical application. PEG materials are nontoxic and biocompatible and can be easily attached to electrode surface, additionally their various length of their chains can assure different thickness of monolayers .