EVPs have been applied as a computationally efficient and useful proxy indicator of the progressibility of molecular scaffolds in fragment screening libraries. In the first example, we have shown how to apply the EVP statistics to the selection of fragments to build a screening library. We subsequently introduced a framework to perform an EVP-based diversity sampling, which is conceptually different from the fingerprintbased selection algorithms typically applied in cheminformatics to date. The SAR case study illustrated how EVPs be applied to derive enhanced understanding from existing SAR data. The relationship of EVPs (and dEVP) to compound potency provides instant information regarding the efficacy of specific EVPs, as well as opening up a route to explore underexploited substitution patterns in compound optimization. We have made the code used in this work available as a set of easy-to-use Jupyter notebooks (see Supporting Information). We anticipate that the EVP methodology will find wide use in cheminformatics within the drug discovery arena.