The stereoselective reactions between BAs and glycans are determined by the spatial orientations and intermolecular distance between BA moieties . The recognition of α2,3 and α2,6 linkages could be improved by selecting appropriate BA receptors. To explore this, we introduced three new BAs: PyreBA, HBACM, and BBA, alongside the five BAs that are employed in the previous sections (4MBA, 1TBA, 3MBA, 4ABA, PyriBA) (Structures are in SI Figure ). PyreBA contains four aromatic rings, known for their distinctive Raman vibrations . Using PyreBA as a model helps us understand the role of aromatic ring vibrations in our platform. HBACM has been previously used in detecting monosaccharides, such as glucose and fructose, as well as oligosaccharides like stachyose and nystose . Similarly, BBA closely resembles the structure of HBACM, with the exception of a sulfur atom replacing the oxygen atom.