where E is the vector of the zero-point corrected DFT energies, M is an m × n stoichiometry matrix with m anchor species and n reactions to form the target from the anchors (not to be confused with the elementary reactions in the mechanism), and E A is the vector of the DFT energies of the anchor species. The stoichiometry matrix M can be constructed by hand, but it is also possible to use linear algebra to determine this from the elemental composition matrix N. N an m × n matrix, but consists of the elemental composition of each species and is, thus, easier to construct and more general since it is independent of the anchor set. We have to construct an elemental matrix for the anchor species N A to determine M.