ChEMBL feed into BioAssay have at least a ~2yr capture lag Three tips can be added for trawling PubChem for additional bioactivity clues that BioAssay may not contain. The first is to check if the structure may be reciprocally linked to a PubMed ID (in the right-hand facet of the abstract entry) wherein activity is reported but that paper was not captured by ChEMBL. The second is to inspect patent matches where filings may include unpublished bioactivity data. The third is to look for similarity matches to the 28,017 PDBe CIDs derived from 87,104 protein structures. While this set has some heteroatom overcount compared to authentic binding ligands, only ~ 13K have BioAssay results. This means that for similar structures to any ligands there is a published target 3D interaction that may well track back to earlier bioactivity reports (n.b. co-crystallised metabolite similarity matches are also of high interest)