Another problem with most of the currently known scoring functions is that they do not take into account thermodynamic properties of the binding energy of a molecule (e.g. entropy change). There are approaches to solve this problem. One such method first checks for possible binding of a ligand-protein complex and then predicts its binding free energy. However this estimation is not sufficiently accurate . Another variant of the thermodynamic regulation tool with molecular dynamics takes too many computational resources . There is currently no compromise between speed and accuracy in estimating the binding energy of molecules.