CG models offer the advantage of reduced computational demands compared to traditional all-atomic (AA) force fields, making them particularly suitable for simulating complex system functionalities. Currently, CG models have been successfully applied to investigate long-time-scale functional studies in complex systems, such as conformational changes in proteins, self-assembly of cell membrane phospholipids and viral capsids, as well as mechanical properties of biomaterials. Due to the immense potential of CG models in studying complex system functions, they have seen rapid development in the last few decades.