Reactions with activation energies above 50 kcal mol -1 are predominantly reported through CTY-TAD. In this dataset, 19 reactions with activation energies above 50 kcal mol -1 were identified, with 11 of them exclusively reported by CTY-TAD. On average, the reactions found only by CTY-TAD have an activation energy of 110.4 kcal mol -1 , while those discovered only by PESmapping have a lower average activation energy of 85.4 kcal mol -1 . Reactions identified by both methods show an even lower average activation energy of 55.9 kcal mol -1 .