Another shortcoming of the current method is the size requirement on the boxes to provide a smooth transition from the FG to the CG model. With the correction potentials to cancel the interface artifacts, smaller SG regions may be explored in the future, so as to further increase the performance. For the AdResS scheme, it was shown that the hybrid region (equivalent to the SG region in the AdSoS scheme) can be completely eliminated upon application of the thermodynamic force to correct for density fluctuations. Note, however, that AdSoS handles the SG region more efficiently than AdResS, as it does not require the evaluation of two separate Hamiltonians.