-Calculated values: 391.2380, 421.2486, Context: "The inhibitors that we discuss here and in the main text all have a pair of rings on each side of the central sulfonamide group; the exception is JEDI-852, which lacks ring 1. The conformation of the sulfonamide group results in a rapid change in direction at this point. The side chains that interact with rings 1, 2 and the inward-directed face of ring 3 of the inhibitor are essentially unchanged in conformation when compared to the EcLpxH/product complex, whether in complex with EcLpxH or KpLpxH (SI Appendix, Figure ). The cores of each inhibitor are, therefore, closely superimposable (SI Appendix, Figure ). The largest outlier is the piperazine ring of JEDI-852, which because it lacks the aromatic ring 1, is able to make a small re-orientation in ring 2 (SI Appendix, Figure ), which presumably optimizes the interaction with the enzyme."