RNA dependent RNA polymerase or RdRp has been used extensively as a drug target in treatment of COVID-19 . Recently one such drug Remdesivir, which is a nucleotide analogue has proved effective in treatment of COVID-19 in some clinical trials. Remdesivir binds to RdRp and stops viral replication thereby preventing replication and multiplication of virus inside host cells . RdRp of SARS CoV2 has several non-structured proteins like NSP12, NSP 7 and NSP8 . Remdesivir binds to active site residues located in NSP12 molecule of RdRp . Earlier by docking studies we investigated several Remdesivir analogues that can be used as potential drug target in treatment of COVID-19 .