To mimic the placement of the amines in nafamostat and camostat on the phenyl of the benzoate, the alphaamino ketone in '2805 was moved from the carboxyl phenyl to the benzoate phenyl to produce Scaffold 2. Scaffolds 3 -6 were designed by introducing methyl amine, ethyl amine, 3-oxyazetidine, and guanidino groups respectively to the benzoate.