In this study, we investigate how much the partial charge engine makes a di erence in partial charge variability across conformers. We define conformer-dependent partial charge variability as the partial charge di erences that result from inputting di erent conformers of the same molecule into a partial charge engine and assigning partial charges. As we will investigate further in this work, this type of partial charge variability is a ected both by the input conformers, the partial charge engine, and the hardware used for the calculation.