In addition to the initial population, the fragment library is another crucial element for the warm start of the genetic algorithm. So far, the fragment library is built by a heuristic selection on a rough analysis of the screening results. It is also possible to add extra fragments manually. In the warm-started COSMO-CAMD framework, one of the intentions is to automatically generate a target-oriented fragment library. To this end, we have conducted a parameter study to analyze how various configurations of the fragment library impact the results of the Design phase, aiming to fine-tune the warm start.