In integrated catalysis, different catalytic cycles are coupled in a reaction vessel to generate products with high complexity from a mixture of abundant and hopefully bio-derived starting materials. Inspired by macromolecule synthesis in living cells, artificial catalysis for the synthesis of polymers with a well-defined sequence and microstructure has been achieved in one pot with the proper utilization of integrated spatial and temporal control. Biological macromolecules, such as proteins and DNA, encode information in their sequences and structures. Likewise, the sequence and structure of synthetic macromolecules dictate their properties. We envisage that integrated catalysis can become the machinery for synthesizing novel molecules and materials with distinct properties. In addition to macromolecules, integrated catalysis can also be an effective tool for multistep syntheses of organic small molecules, such as pharmaceuticals.