Kinases and GPCRs essentially agreed on the predicted actives proportions analyses, the only exception being the n_interactions coefficient, non-significant in the semi_resampling strategy (β = -0.011, p = 0.3, Table of the Supporting Information). Regarding performance, the explanatory linear models on GPCRs led to facts equivalent to those of kinases in baseline metrics, in absolute and in baseline-adjusted performance. Regarding adjusted performances, semi_resampling significantly outperformed no_resampling in 3 metrics instead of 4 (Table of the Supporting Information), which still made it preferable. Supplement 3 gathers with detail all the results obtained in the analysis of the GPCR family.