There are several criteria in searching the set of 15922 for good choices: 4. Satisfactory visual geometric docking fit to the site and individual atom interactions between protein and ligand. 5. Synthesis, maybe at scale, is important and is analyzed by inspecting individual molecules. The iterations of the molecules in Ligand GA follows the highest scoring stereoisomer of the nonisomeric molecule. Molecules are represented in textual non-isomeric SMILES. Upon expansion of one of these many stereoisomers will be generated, and the highest scoring one is what guides the selection from one iteration to the next of the non-isomeric population.