In summary, by involving the X:⇔:Y repulsion, one can extend the two-body oriented hydrogen bond X⋅⋅⋅R to the three-body coupling X:R-Y bond that unites a pair of elastic and polarizable dipoles and being inclusive of the inter-and intra-dipole interaction and their correlation. One can amplify the X:R-Y bond to at least three situations of electron lone pair engagement, dipolar or atomic vacancy replacement, and charge polarity inversion. The decisive factor of the amplified hydrogen bond is the combination of the X:R attraction and X:⇔:Y repulsion regardless of the negativity specificity of the constituent elements, which entitles the X:R-Y bond with disparate geometry, energy and specific heat cooperativity, and polarizability, endowing the extraordinary deformation adaptivity, damage recoverability, perturbation sensitivity, catalytic capability, and chemical reactivity of systems involving the coupling X:R-Y interactions. The amplification has led to substantial improvement in understanding water ice anomalies, hydration interfacial identities, CHNO molecular assembles, molecular physisorption, and oxidation, as well as promising ways of thinking about monatomic catalysis and low-dimensional high-TC superconductivity. The impact of further extension and application of the X:R-Y bond would be enormous on areas far beyond the presently addressed issues such as cell engineering and life science.