DAPAR and ProStaR 27 () are two tools dedicated to the discovery of differential analysis of quantitative data generated by proteomic experiments. DAPAR is an R-package which provides five processing steps (filtering, normalization, imputation, aggregation, and difference analysis), based on those functions, ProStaR provides an R-Shiny web platform for interactive exploring. The advantage of ProStaR lies in its ability of online analysis and embedded detailed user tutorials to help users get started. There are various types of input, supporting the input of proteinGroups.txt files, as well as Proline and MSnset files. Several parameters are provided to allow users to interact with important filtering and statistical steps. The user needs to manually annotate the condition and select multiple parameters, and the tools do not provide QC reports on the data analysis results or the original intensity values.