Besides the standard analysis of predictive models and the comparison with models that refer to the same test dataset of Husskonen as described above, we performed a comparative evaluation of our model against well-established solubility prediction tools. To this aim, we selected five standard compounds that are easily available, for which literature solubility values are available, and for which solubility data can be determined in our labs. The combination of solubility values from the literature and our labs (experimental part given in SI, Section 5) as reference values allowed us to gain additional confidence in the correctness of the literature values and allowed us to identify potentially problematic compounds, for that the measurement details such as the pH might be crucial for the results but perhaps not included to the literature data. We selected the models of VCC labs, 29, of the Helmholtz research field information and the Karlsruhe Nano Micro Facility, which support the maintenance of the software Chemotion ELN. We acknowledge support by the Deutsche Forschungsgemeinschaft and the Open Access Publishing Fund of the Karlsruhe Institute of Technology. We thank Pierre Tremouilhac for supporting the project IT-wise.