After validating the control scenario, the experimentation scenarios were performed. These experiments follow a similar procedure than the control scenario. The experiments try different FA metabolites and SARS-CoV-2 variants. However other metabolites such as (6s)-5-methyl-tetrahydrofolate, (6S)-5,6,7,8-Tetrahydrofolate, (6R)-5,10methylenetetrahydrofolate(2-) and FA itself were also tested. Although these metabolites bind with high affinity to the ACE2 receptor, MD simulation found that they do not prevent the binding of RBD with ACE2, and therefore are not reported in this work.