Here the aim was to interrogate the lipid diversity accounting for differences between plaque versus background and between plaque cores and peripheries of individual plaques, respectively as well as for differences and between plaques of animals of 18mo and 23mo of age. For this the data was analyzed through two independent approaches. First the data was interrogated in a Y2 matrix where either plaque versus background, or periphery versus core of the plaques, was analyzed across all animals both for 18mo and 23 old animals (Figure ,f, k,l;