Nitazenes are usually added to counterfeit tablets (i.e., benzodiazepines) or combined with heroin, where numerous incidences of overdose have been reported due to unintentional consumption. Recent media reports are also emerging of e-cigarettes spiked with nitazenes, in addition to a WEDINOS submission from November 2022 . An overdose death from opiod toxicity associated with the use of a Nitazene-continuing e-cigarette has also been reported in Australia 22 . Given their high risk, we suggest the presence of nitazenes in e-cigarette liquid is worthy of detailed monitoring.