We have compared the initial of the oxidative damage and protective hole-hopping mechanisms of two LPMOs, namely TaAA9 and LsAA9. The two investigated LPMOs have very similar active site architectures. We find similarities as well as remarkable differences in the protective mechanisms, highlighting that investigations on LPMOs as far as possible should consider several LPMOs. Regarding the similarities, our calculations show that the [CuO] + moiety in the Cu(II)-oxyl intermediate (1) for both TaAA9 and LsAA9 is capable of oxidizing tyrosine to a tyrosyl radical. The electronic structures of the formed tyrosyl radicals are overall similar in the two LPMOs, based on their spin densities and their calculated UVvis spectra. The latter is commensurate with recent experimental investigations, with intense peaks around 400 nm.