Organic semiconductors (OSCs) composed of earth-abundant elements are promising biocompatible materials for assembling light-driven enzymatic biohybrid systems. Solution processable π-conjugated OSCs exhibit bandgap tuneability at the molecular level , and the bulk heterojunction (BHJ) design supported by a built-in electric field for organic photovoltaic (OPV) applications facilitates efficient charge separation at the nanoscale. Hence, the solar energy conversion efficiency of OPV devices has increased sixfold, reaching 20% over the past two decades . Their early onset potentials and high photocurrents , especially in neutral pH solutions , have attracted substantial interest towards solar fuel production, with state-of-the-art synthetic catalyst systems sustaining H2 and syngas production for days. However, effectively interfacing OSCs with enzymes remains challenging . Early works on the electrochemical wiring of enzymes to electrodes have focused on (photo-inactive) redox polymer mediators comprising of viologen-or osmium-based moieties tethered to a non-π-conjugated backbone . Despite being non-diffusional, they remain limited by slow electron hopping and the polymeric mediator that controls the driving force (potential) available for the enzyme . Direct enzymatic electrochemistry is thus an appealing strategy for optimising electron transfer and maximising efficiency at the bioticabiotic interface of biohybrid PEC devices.