Research suggests the potential of GPCRs and kinase-targeting vaccines in several diseases. For instance, a vaccine developed against Aurora Kinase A (AURKA) and cyclin-dependent kinase 7 (CDK7), has been proven effective against solid tumors . Moreover, calciumdependent protein kinases have been targeted for developing vaccines against Toxoplasma gondii which causes zoonotic infections which have been reviewed in a study ). This suggests the potential of GPCRs and Kinases to be targeted for the development of Therefore, targeting the GPCRs and Kinases is a unique and interesting strategy but has several challenges due to the problem that they need to be targeted indirectly for vaccine development, unlike the anti-viral drugs which might be developed directly against GPCRs.