Among physical methods, different methods using the same force field did not always agree in predicted BFE value for the same systems. This was observed for methods using GAFF2.11 on both the WP6 and CD datasets, and with methods using OpenFF2.0.0 for WP6 predictions. When we directly compared methods using GAFF2.11 ( 11), in the majority of cases at least half of the predicted BFEs differ by more than 2 kcal/mol. The origins of the differences in results remain unclear.