Distribution of the QED values (Figure ) showed that the median values of all databases, even the ChEMBL's DNMT1 inhibitors used as a reference, do not comply with the suggested threshold of 0.67 or higher. In this case, the mean from ChEMBL actives will be more relevant because the aim is to find new hits for DNMT1. Since hits are considered for earlier stages of drug discovery, biological activity normally carries more relevance than drug-like properties or potency. This could explain the lower values from known inhibitors with reported activity in ChEMBL. Nevertheless, QED values are useful for ranking and prioritizing the synthesis of de novo compounds or libraries. Remarkably, most of the designed databases have similar or better QED mean values than the ChEMBL's DNMT1 inhibitors. Molecules designed with DNMT1 inhibitors as the source of fragments decreased slightly.