To overcome the slow sampling at thermodynamic states near or below the folding transition temperature, a common strategy in foldamer and protein simulation literature is to perform replica exchange molecular dynamics (REMD) simulations. In REMD, simulations are run concurrently in separate simulation boxes, with configurational swaps between boxes attempted periodically. Typically, the parallel simulation cells differ in temperature (parallel tempering). These swaps are either accepted, in which the configurations of the two simulation boxes are switched, or rejected, in which the configurations stay the same, in accordance with a Metropolis acceptance criterion: