Compounds containing one or more phosphorus atoms in the P(V) oxidation state are important to chemistry, biology, and medicine (Scheme 1A). These include marketed antiviral drugs such as such as Tenofovir alafenamide and Remdesivir, the latter being an effective treatment for the Ebola virus which was also approved for use against SARS-CoV-2. Other relevant compounds include Fosinopril, a compound used to treat hypertension and heart failure and WHO essential medicines listed chemotherapy agent Cyclophosphamide. In addition to being common APIs, P(V) containing compounds are also highly relevant motifs in agrochemistry. A representative example is the herbicide Zytron developed by Dow. As such, the development of efficient methods for the preparation of enantioenriched P(V) containing compounds is crucial.