The link between external exposures and the ensuing disturbance of the internal metabolome is one step to elucidating disease development, which is part of the broad scope of exposome research. With our approach, connections between xenobiotics and metabolites were indicated. A strong correlation between ethylparaben and the carboxylic acids fumaric acid (0.68) and malic acid (0.67) and the amino acid alanine (0.62) were uncovered. Alanine (0.64), fumaric acid (0.63) and malic acid (0.6) were connected to benzophenone-1, too. The matrix also strongly correlated mono butyl phthalate and aspartic acid (0.66). These correlations highlight only potentially interesting links between the exposome and the metabolome and might be seen as a starting point for deciphering causal connection. Additional, in-depth experiments will be necessary to prove these links in future ExWAS investigations.