These candidate materials can then be tested, either computationally or experimentally, to measure their actual performance. Moreover, statistical relationships can be established and investigated, gaining insight into the link between microscopic structure and macroscopic properties -provided that the ML algorithm chosen has a good degree of interpretability. However, it is important to note that the flexibility of frameworks, and its impact on their responses, are very difficult to consider in high-throughput screening procedures. Taking into account the flexibility of materials typically induces a higher computational cost, either by increasing the number of degrees of freedom, or by requiring more accurate force fields -"generic" or "universal" force fields are not suitable for that task. Therefore, there are relatively few systematic studies of the impact of flexibility on the properties of materials, and it is still a wide open question.