The FR has also been carried out under hydrothermal conditions . Using 0.5 M HCHO solution at 200 °C and 100 bar in a continuous flow reactor, Kopetzksi et al. reported that contrary to the reaction at low temperature, hexoses were formed in low concentration and pentoses were formed in high yield compared to lower temperature reactions. 2-Deoxyribose and other deoxy compounds were detected in these reactions, but little effort was made to relate the yields of these compounds to reaction temperature. Additionally, the induction period does not occur under these conditions, which points to a larger issue, that while the FR is robust and obeys Arrhenius behavior, without the required condition that the starting materials be sufficiently concentrated, the reaction does not occur at all, and instead, the reactants degrade via pathways such as the Cannizzaro reaction.