takes approximately 30-40 hours to execute using this architecture, for the systems studied in this work (10x longer than the shorter 20 ps / window simulations for each system). The difference in time to a REMD-EVB simulation of the corresponding length (e.g. our 10 x 20 runs) might not seem large: only between 1.5 to 2.3-fold reduction in compute time. However, even this seemingly small difference becomes significant on longer simulation timescales: extrapolating our conventional EVB simulations to ~100ns / trajectory timescales (the longest REMD-EVB simulations performed in this work), the difference in human time per trajectory is substantive.