To extend our templating strategy to bifunctional acid-base sites, we designed a new non-symmetric crosslinked ligand dimer, abbreviated H8XL-AB, which incorporates a tertiary ester linkage on one end and a tertiary carbamate linkage on the other. The two halves of the dimeric ligand are bridged by a short alkyl chain (Fig. , see SI for synthetic details). After framework synthesis, thermal cleavage of the tertiary ester and carbamate groups should lead to bifunctional carboxylic acid and benzylamine pairs positioned on adjacent ligands roughly 7 Å apart (Fig. ).