When considering only 2-hour reaction time points performed at different temperatures, PCA reveals similar patterns with solvent (Fig. ). Again Bu2O reactions have most 1a remaining and, except for the lowest temperature (80 C) reactions, DMF and propylene carbonate result in the most phenanthridinone 2a. Most solvents show increased conversion of 1a with an increase in temperature. The greater quantities of side-products in MeCN and MEK can be seen again but outcome for both BuCN and the dual solvent system is variable. In addition to product 2a, higher quantities of aniline 16a and 6a are associated with DMF and propylene carbonate, whilst Bu2O and toluene have the lowest values. Much of the variance along PC2 is due to unusually high proportions of some compounds being recorded for a few observations, emphasized by the scaling. As the replicate experiments did not have similar outcomes, these unusual observations could be considered outliers due to reaction sampling or analysis errors.