The second measure of accretion was changes in the Solvent Accessible Surface Area (SASA) of the simulated lipids over time, a measure of their compactness or conversely their accessibility for further interactions (Figure ). The SASA plots of the different chemistries start high, then decrease as lipids aggregate and become less exposed to water. Admittedly this analysis is sensitive to the molecular size of the employed lipids, so that chemistries that involve bigger and bulkier lipids tend to display greater solvent accessibility. Accounting for this shift, the plots follow a similar trend to those displayed in the cluster size examination.