In combination with the presented cytotoxicity of ATV on various glioblastoma cell lines this strongly supports the rationale to use ATV for glioblastoma chemotherapy. The dismal prognosis of glioblastomas is not only attributed to rapid tumor growth (and poor responses to chemo-and radiotherapy), but also to the diffuse intracerebral spread of migrating tumor cells. [69, 70] We therefore examined the effects of ATV on the viability and cell migration of GBM6840 cells. This human cell line has been derived from a highly aggressive pediatric cerebellar glioblastoma multiforme ,