The open question is how to better understand how large scale processes, or even lab scale mechanical influences, manifest in the molecular scale and what is the proper treatment of the value ϕ in these cases. Simply, how do macroscopic deformations and different deformation paths project onto the strain state of the molecule, µ. This will need to involve a range of coupled studies using experimental, computational, and theoretical efforts that bridge numerous time and length scales such that the resulting physics can be utilized to better understand the mechanochemical implications in complex, reacting systems with distributions of states.