Next, we directed our focus to the oxytrifluoromethylation of alkenes through a three-component process using photocatalytic single electron transfer (SET) with Ru(bpy)3(PF6)2, as reported by Koike, Akita et al. In the oxytrifluoromethylation campaign (Figure ), we simultaneously optimized five reaction parameters: styrene concentration, CF3 source loading, photocatalyst loading, residence time, and light intensity. Two objective functions (yield [%] and throughput [mmol h -1 ]) were targeted for optimization. Similarly, for each substrate, a total of 14-25 experiments were conducted within a 3-10-hour timeframe. The optimization process utilized fast F NMR analysis (2-minute per measurement) for molecules 7, 8, 9, and 11. However, molecule 10 required a longer optimization time of 19 hours due to the use of H NMR for quantification. To ensure high accuracy, a 16-minute analysis window was allocated per reaction. As previously described, our experimental procedure involved 6 initialization experiments, followed by refinement experiments for each optimization campaign.