Gosu et al. performed MD simulations of human wild-type and mutant TLR3 to get insights into the dynamic nature of the dsRNA-bound TLR3 complex. They investigated several complexes: dsRNA-unbound TLR3 wild-type dimer (apo_dTLR3WT), dsRNA-bound TLR3 wild-type dimer (dTLR3WT-dsRNA), dsRNA-bound TLR3 dimer with a leucine-tophenylalanine mutation at position 412 (dTLR3L412F-dsRNA), and dsRNA-bound TLR3 dimer with a proline-to-leucine mutation at position 680 (dTLR3P680L-dsRNA). In TLR3, L412F polymorphism was associated with several human diseases, while the P680L mutation was found as one which reduces the binding affinity of dsRNA to TLR3 and affects subsequent signalling.