In response to these challenges, the ASPIRE Integrated Computational Platform (AICP) was developed at the National Center for Advancing Translational Sciences (NCATS/NIH) (This content is a preprint and has not been peer-reviewed.). AICP leverages a large-scale open source graph knowledge graph of chemical reactions, utilizing well known graph transversal algorithms . Therefore, it falls under the evidence-based branch of Computer Aided Synthesis Planning (CASP) approaches . Such methods have the benefit to generate synthesis by utilizing empirical data, involving reaction conditions and experimentally determined yield and purity. Therefore, these methods are of invaluable help in identifying robust synthesis routes in high-throughput synthesis setting.