We additionally examined whether the PFKDOPA-silica beads catalyze hydrolysis of other β-lactam substrates. Figure presents the relative concentration percentage of penicillin and its hydrolysis product, determined via LC-MS, following placing in a column containing PFKDOPA-coated silica beads (10 µm diameter). Indeed, the graphs in Figure demonstrate that incubation of penicillin with the PFKDOPA-coated beads gave rise to significant hydrolysis (almost 95% of the penicillin placed in the column was degraded within 96 hours), while incubation with bare silica beads (not coupled with the PFKDOPA fibrils) did not exhibit hydrolysis. This outcome echoes the result recorded in the case PFK amyloid fibrils alone (e.g., Figure ), confirming that the FKDOPA-coated bead constructs can be successfully employed as a vehicle for catalytic β-lactam degradation.