Dissolution dynamic nuclear polarization (d DNP) is a more general technique, allowing one to polarize a broad variety of molecules to high polarization levels. Indeed, d DNP has established itself as the hyperpolarization method of choice for polarizing a wide range of small molecules . This is achieved by bringing the sample to cryogenic temperatures (typically 1.0 -1.8 K) commonly at fields in the 3.3 -7 T range in the presence of unpaired electrons, whose polarization is near unity under these conditions. The electron polarization is transferred to the nuclear spins via microwave irradiation after which the frozen sample is dissolved using a hot solvent and transferred to an NMR spectrometer or MRI scanner for use of the hyperpolarized solution in the liquid state. This technique has the advantage of broad applicability, with polarization levels of tens of percent regularly achieved . A first demonstration of d DNP coupled with ZULF-NMR detection was recently presented , where [1-13 C]pyruvic acid was hyperpolarized and detected with a portable zero-field spectrometer.