Understanding noncovalent interactions between organic molecules and water clusters is required in order to understand the chemistry of aqueous organic phenomena. Secondary interactions play a critical role in forming organic molecule-water cluster complexes. While contact between a heteroatom in the organic probe and a -OH group from the cluster is required for a strong interaction, additional interactions from aliphatic hydrogens can provide extra stabilization to the complexes. We showed that the nature of the water molecule interacting with the organic species, whether it is acting as a single or double HB acceptor or donor, determines the strength of binding energies of the complexes. The nature of the organic probe is also an important determinant of HB strengths. Therefore, the computational study of AOC reactions requires consideration of the size of the water cluster and the nature of the secondary interactions, the HB donors and acceptors, and that of the organic molecules. The presence of different moieties in the probes can lead to a more complex distribution of the BEs; for instance, methyl acetate can engage in many of the classes of interactions identified in this work. Overall, our work illustrates the intricate nature of reactions in aqueous phase. This work also provides a novel benchmark data set for organic probe-water cluster binding energies that can be used, for example, in the assessment of computational methods that describe noncovalent interactions.