As a representative biosystem, we examine the vdW polarization effects in the Fip35-WW protein, whose plasmon-like interactions with solvent were previously studied in detail . From folding trajectories sampled in Ref. , we selected three representative atomic structures corresponding to unfolded, folded, and transition states. To focus on intra-protein interactions, water molecules and counter-ions were removed, and the result- ing geometries were used for PBE and MBD calculations.