Finally, the RPLC classification model was applied to a set of small molecules (i.e., molecular weight < 1000) from the NORMAN SusDat database. In total, 80503 chemicals were within the applicability domain with leverage values ≤ 0.209, 6570 compounds had leverage values between 0.209 and 1, and 4664 compounds had even larger leverages. This showed that the RPLC classification model was suitable for a large variety, 87.8%, of compounds present in SusDat. The model predicted that 79.0% of the compounds would fit 'inside' the RPLC subspace, 2.0% was 'maybe' in this space, and 19.1% was 'outside' of the RPLC subspace.