We begin with ∆G self i,i . A parity plot of the predicted versus reference values of ∆G self i,i / (RT) and a summary of the computed statistics is provided in fig. and table 1, respectively. The statistics in table 1 are computed for Y = ∆G self i,i / (RT), with the summation carried out over all N = 148 molecules for which reference data is available. Note that we are interested in the dimensionless ∆G self i,i as it is the quantity of interest in eq. ( ). i,i / (RT) using the SM12, SM8, and SMD universal solvent model, as indicated. The blue lines corresponds to the y = x line, and the dashed blue lines correspond to ±1.5 and are drawn as a reference; the value of 1.5 was used based on the RMSE for the SM12 predictions. Table . A summary of the squared correlation coefficient (R 2 ), root mean square error (RMSE), average absolute percent deviation (AAPD), and mean unsigned error (MUE) for the values of ∆G self i,i / (RT) predicted using the SM12, SM8, and SMD universal solvent model as compared to the reference data. Overall, we find that SM12 and SM8 outperform SMD, with SM12 performing slightly better than SM8. The top performance of SM12 is in agreement with the recent SM12 parameterization . Visually, it is clear in fig. that SM12 and SM8 offer a noticeably smaller spread in the data as compared to SMD, corresponding to a smaller overall error.