To a solution of racemic acetate 3d-q (41.8 mmol, 1 eq) in a mixture of t-BuOMe (100 mL) and a phosphate buffer (pH = 7.2, 100 mL), PLE (84 mg) was added. The mixture was stirred at 50 °C until the conversion of reaction was approximately 50%. When the pH of the reaction mixture decreased below 6.0, a saturated solution of KOH was added to adjust the pH back to 7.2. The reaction progress was monitored by 1 H NMR spectroscopy. Afterward, the lipase was filtered and washed with t-BuOMe. The filtrate was separated, and the organic layer was dried over Na2SO4 and evaporated in vacuo to afford a mixture of the alcohol and acetate. This mixture was separated by column chromatography on silica gel using n-hexane -THF (10/1, v/v) as the eluent to afford pure products (2R,4R)-1d-j / (R)-1k-q and (2S,4S)-3d-j / (S)-3k-q.