In this section we detail enhanced sampling approaches that are most amenable to parallelization. In conjunction with parallel replicas of trajectories, enhanced sampling offers powerful way to sample biochemically rare transitions. However, parallelized simulations and dataset generation relies heavily on the asynchronicity of each replica being run; that is, each simulation is run independently of the others. As such, some methods such as Replica Exchange may be unsuitable for parallelization for simulations. Sampling methods can risk generating biased datasets and offer tradeoffs in ensemble generation, and it is most critical to be aware of the biases and assumptions being made with each enhanced sampling technique.