Numerous individuals infected with monkeypox are also infected with human immunodeficiency virus . In HIV-infected patients with severe immunosuppression and untreated HIV infection, MPXV infection may cause severe illness . Compared to HIV-negative cases, HIV-1 patients who contracted monkeypox were significantly more likely to develop larger rashes, genital ulcers, secondary bacterial skin infections, and longer disease duration . According to research conducted in Africa, HIV-positive individuals are at a greater risk of developing severe MPXV infections. Individuals with uncontrolled HIV infection and monkeypox have a poorer prognosis, including more extensive and persistent lesions, more complications, and multiple deaths . In a preliminary cohort analysis of the current large outbreak in Germany( ), but only a small number of people with HIV developed viremia or severe immunosuppression.