NTA is a bottom up approach where minimum or no prior knowledge about the structure of the chemicals in samples is used during the identification process. The ultimate goal of most NTA workflows within the exposomics area is the unequivocal identification of all chemicals present in a sample. However, this process is extremely difficult, time consuming, and uncertain, especially when applied across multiple environmental compartments (e.g., air, water, soil, biological fluids, etc.) and spatiotemporally. Consequently, when looking at the number of new structures discovered in environmental samples using NTA strategies in the past five years, those studies resulted in less than 2% of a database such as Norman SusDat.