With respect to pocket descriptors, both property and geometric, the results show a substantial number of them with PCC close or above 0.5. Overall, pocket property descriptors show the highest difference between static and dynamic treatment. Out of 8 best correlating time series descriptors only one static descriptor (pocket_hydrophobic) has a comparable correlation. The results show that simple pocket composition features, such as atom or bond types count, which change with respect to ligand movement, correlate with high PCC values with small molecule affinity.