In summary, we have presented a simple and straightforward strategy for the construction of N-substituted quinazolinones through visible-light promoted direct coupling reaction of quinazolinones with alkylamides. Synthetically important and highly functionalized N-aminoalkyl quinazolinones were afforded in high level of yields (up to 86% yield). This process features mild reaction conditions and the tolerance for a wide range of functional groups. Further extension on other transformations is underway in our lab.