Although this latter molecule can adsorb onto PSPMA via electrostatic interactions , it is known to typically follow the preliminary adsorption of fibronectin in vitro . Therefore, it could be proposed that high BMP2 surface adsorption results in the capture of fibronectin and its deposition at the surface of PSPMA brushes, which in turn enhances further remodelling and deposition of collagen I, and potentially other proteins. However, whether this results from a direct ligation mechanism (through the binding of fibronectin to BMP2), or whether this arises through an upregulation of fibronectin secretion and assembly upon BMP2 ligation of corresponding receptors remains unknown.