1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (EDC) is widely popular as a coupling agent in synthetic organic chemistry. Due to the easy workup of EDC, high yields and lower reaction time, results in pure products without column chromatography. Herein, we wish to report a simple and convenient method for the synthesis of isomalemide through dehydration of maleamicacid, succinamicacid in the presence of EDC in dichloromethane solvent at room temperature.