This study presents strategies for utilizing plant extracts in the battle against drug resistance. Functional group analysis, GC-MS data, and antimicrobial screenings from various sources indicate that combining plant extracts with drugs or other structurally functional reagents can lead to significant structural and functional changes, resulting in the formation of intermediate or new compounds. These compounds may act individually or synergistically to combat multi-drug-resistant bacteria. For example, the GC-MS analysis by revealed potent anticancer properties, suggesting that these combinations could also be effective in antifungal, anti-inflammatory, antiviral, and anticancer applications, potentially yielding positive outcomes similar to the observed antibacterial effects. Therefore, this strategy holds significant promise and could be extensively explored using advanced synthetic methods and tools to achieve optimal results in drug discovery and development. By harnessing the potential of plant extracts and employing sophisticated techniques, we can develop new treatments that effectively address the growing challenge of drug resistance.