We also report the relative contributions of the SP and ML framework to the force predicted by the TL PC model (i.e., the forces predicted by the IBI parameterization and the correction given by the NN to yield F TL CG , Fig. ). Most of F TL CG is supplied by the SP model with a minor correction from the NN. The NN correction becomes negligible for the R4 and R5 mappings, which indicates the correction is primarily associated with the intramolecular interactions missed by the bond and angle potential based decomposition in the SP model and that the intermolecular forces are increasingly stochastic. Thus, only the mappings with intramolecular modes, R2, R3 and PEG-M1 show any noticeable contribution from the ML framework in the TL models.