There are multiple ways in which the observed nanodomains of UoB-100(Dy) may affect its physical function. First, we note the potential impact of the linker bending, as it occurs within the ferrohexapolar nanodomains, but is absent along their edges. Since the linker bending affects the size of its pore windows, UoB-100(Dy) may exhibit disorder-dependent behaviour concerning gas storage and transport. Or, if the linker bending is a mode of mechanical flexibility, UoB-100(Dy) could show an enhanced elastic stability through combinatorial mechanics, as reported previously for TRUMOF-1. Moreover, because the linker possesses a cavity with the ability to coordinate to an added guest component, the possibility of modifying the bending arises. This prospect of nanodomain modification is what sets UoB-100(Dy) apart from other nanostructured disordered systems, such as UiO-66, relaxor ferroelectrics, 8 high-entropy alloys, or charge density wave compounds. Finally, as Dy exhibits strong magnetic behavior, it is likely that the nanostructured disorder affects the magnetic structure and behavior of UoB-100(Dy). It may be interesting probing UoB-100(Dy) for the magnetocaloric effect, which has been reported for Dy-coordination polymers such as DyOHCO3 and Ln(HCO2)(C2O4). More generally, this study shows the importance of local-structure analysis in MOF chemistry. Often, signs of non-average effects are ignored, leading to the incorrect assignment of components, such as the metal cluster geometry in Zr-MOFs. Likewise, structures with similar cluster geometries to UoB-100(Dy) may have been observed before, but difficulty in structure analysis prevented the data from being disclosed. As we demonstrate for UoB-100(Dy), both DS analysis and multimodal modelling are key in deciphering such cases. In parallel with structural disorder analysis, the use of disorder as a tool in framework design becomes increasingly critical. This targeted design is a significant challenge that must not be overlooked, as it involves navigating a large configurational energy landscape and therefore some (synthetic) trial and error. In our case, the approach of combining a flexible linker with a rare-earth metal proved to be efficient. There is no reason to think that the extension to other rare earth elements is not feasible, although it might affect the disordered structure. Ultimately, solving the nanostructured node disorder in UoB-100(Dy) opens a new avenue of exploring the control thereof, be it through the addition of guest components, changing metal type, or other synthetic parameters.