These conclusions highlight the importance of accounting for a varying potential energy surface as a function of time in MD simulations, a factor that classical MD simulations are not capable of reproducing. This also has implications for the Coupling Model , where the changing of the PES as a function of time (and temperature) means that the relative coupling between molecules is dynamic and must be accounted for. However as previously mentioned, the PES is not only dependent on static atomic positions, as any change in these values will cause a corresponding change in the PES. For example, changing a single dihedral angle (as shown in Figure ) results in the breaking of an intra- molecular hydrogen bond. A new hydrogen bond can easily form along this direction, provided that the OH group can readily rotate so as to take advantage of this, which can occur throughout the time-evolution of the system. Thus, forming a model of amorphous dynamics would require every combination of structures and interactions to be known. Given these conclusions, the glass transitions and temperature-dependent dynamics can be related to the number of accessible states that the system has, implying that a thermodynamic partition function might be an appropriate means of predicting such phenomena. However, because the PES is both temperature-and time-dependent (since the various conformations that the molecules can achieve will change the PES accordingly), the expression would become much more complex, depending on both the temperature and time-dependent barriers. Thus, while the problem might appear intuitively simplistic, it becomes highly complex to solve analytically. However, approaches to its solution are currently under investigation.