This Data Descriptor provides information on a UHPLC-HRMS 2 dataset of 76 NEs from the Celastraceae family , and the dereplications results obtained through different annotation strategies (GNPS , ISDB , Sirius , and CANOPUS ). The set is part of the Pierre Fabre Laboratories (PFL) plant collection. The PLF from 1998 to 2015 conducted highthroughput screening (HTS)-research on the discovery of bioactive NP as plant anticancer agents. Their NEs HTS program (stopped in 2015), ended up with c.a. 17,000 unique specimens of plant parts, which made it one of the largest private collections in the world .