The degree of correlation between the DE(oxo) and DE(HAT) reaction energies varies by metal. Notably, Cu SBUs show the strongest correlation (Pearson's r = -0.94) between the two reaction energies with a steep slope of -0.95 (Figure ). We attribute this strong linear behavior to the formation of a terminal Cu-oxyl species on Cu SBUs instead of Cu-oxo intermediates, as observed from the relatively low Mayer bond valences of the oxygen atom in their oxo intermediates (Supporting Information Figure ). In contrast, the Mn SBUs show weak correlation between DE(oxo) and DE(HAT) reaction energies (Pearson's r = -0.44) with a shallow slope of -0.21 (Figure ). This suggests that the formation of a stable Mn-oxo species does not come at the cost of decreased HAT reactivity. We also observe limited overall and metal-specific correlation between the reaction energetics and quantum mechanical descriptors (e.g., frontier orbital energetics, spin density, and Mayer bond valence of the metal-oxo) commonly thought to predict C-H activation reactivity (Supporting Information Figures and). The lack of correlation of reaction energetics with underlying electronic descriptors provides further evidence for LFER disruption. Therefore, Mn MOFs appear to be highly promising for methane to methanol catalysis (Figure ).