Examining the uptake of tubule-like tile-based DNA nanostructures, carrying siRNA, folic acid, and fluorescent dyes, by GFP-expressing HeLa cells , a nanoplatform constructed from branched DNA developed to simultaneously deliver gene editing (sgRNA/Cas9, which targets DNA in the nucleus) and gene silencing (antisense, targeting mRNA in the cytoplasm) components integrating with an active targeting aptamer for the purpose of targeting the tumorassociated gene PLK1 , are among some examples of oligo drugs delivery with DNA platforms. The initial demonstration of DNA origami as a framework for co-delivering a chemotherapy drug and a meticulously arranged gene to target multidrug-resistant tumors (specifically MCF-7R) both in laboratory settings and within living organisms involved a DNA nanokite decorated with various functional elements for targeted delivery and regulated release, including the MUC1 aptamer . DNA tetrahedrons, distinguished by their precise shape and size control, outstanding biocompatibility, numerous sites for targeted decoration, stability, and straightforward synthesis, exhibit considerable potential for molecular diagnosis and targeted drug delivery, including nucleic acids , such as self-assembled triangular DNA nanoparticle hybridized with mTOR single-stranded siRNA resulting in high transfection efficiency into NCI-H292 cells or a double-bundle DNA tetrahedron integrated with antisense oligonucleotides knockdowning proto-oncogene c-raf without transfection agents .