Starting from the aforementioned results, we asked ourselves whether the developed system could more generally be used to exploit the change in sublimation properties of an enantiopure compound when it directly interacted with another chiral species. To evaluate this idea, various sublimation experiments milling D-(+)-Cph with an equimolar amount of a chiral additive capable of coordinating the ketonic group of the substrate for 120 minutes were performed. A DMSO solution containing 1,3,5-trimethoxybenzene was used as liquid trap of the sublimate, and a nitrogen gas flow of 0.125 L/min was used as carrier, as previously recognized being the optimal regulation for this analyte (Figure ).