The advantage of IFPs is that they emphasize important residues and interactions as seen based on one or more ligands; the disadvantage is that not all possibly relevant interactions have been seen, yet. Note that combining the IFP information with KiSSim -using only interacting residues in the KiSSim fingerprint -can improve the KiSSim performance as discussed in the KiSSim evaluation using profiling data section. Third, we use kinase similarities calculated with the SiteAlign methodology (SiteAlign), from which we adapted some of the physicochemical KiSSim features, to confirm that the KiSSim fingerprint adds relevant kinase-focused information.