The concept of self-assembly arose with supramolecular chemistry in the 60s and the description of the recognition abilities of covalent macrocycles such as crown ethers or cryptands. Various viruses or cargo proteins exhibit highly-ordered geometrical shapes. The use of reversible interactions such as hydrogen bonds or van der Waals interactions to construct structures through the assembly of topologically well-defined building blocks is an efficient mean to access supramolecules with a higher complexity or novel physical properties. Amongst these, the coordination cages -also known as metal-organic polyhedra (MOP) -are formed through the combination of a polytopic divergent coordination linker and a metal or metal cluster. One of the most frequently encountered secondary building unit are the metal paddlewheel clusters composed of anionic carboxylates and metals (commonly Cu(II), Rh(II), Cr(II) or Mo(II) ). Their porosity, their stability in various media and their ease of functionalization on the organic moieties makes them excellent candidates for catalysis, for ion transport, drug-delivery, or gas sorption. Encompassing the cages with redox-active functionalities makes them stimuli responsive and could lead to a variation of their encapsulation abilities. In that regard, the use of electron-rich moieties such as tetrathiafulvalene (TTF) in combination with various coordinating units, has been thoroughly explored as well in self-assembled systems for guest encapsulation. Macrocyclic fully organic species using S-alkylated TTF have been described, but to the best of our knowledge not incorporated in metal-organic cages despite their easy synthetic availability. Furthermore, the flexibility of the cage is a key factor for proper guest enclathration. Most of the ligands used in metal-organic cages design have nevertheless highly restrained degrees of freedom.