A Twitter bot is an automated program on Twitter controlled through Twitter API. Bots are common on Twitter, and they usually deliver tweets like news and blog updates . Twitter bots are also used for scientific purposes, such as posting updates of journal publications or preprints. While most bots automatically post tweets, they can also respond to replies from other users. We can construct an interactive application using Twitter API. In this paper, we report case studies of cheminformatics tools demonstrated on Twitter.