During the benchmarking study two different Cypher queries were used to obtain synthesis routes, the first denoted as FG (full graph) and the other as SP (shortest path). The SP query was designed to handle excessively long query times on the order of hours on databases with multiproduct reactions included. The FG query finds all possible paths between target and connected Substance nodes. Search depth refers to the maximum number of nodes in the path between the target and substance node. Since a reaction node has to proceed backwards from a target substance node, a search depth of 6 is equivalent to 3 reaction steps away from target compound. The query is defined as follows: