With eight novel analogues, alongside 2CPTZ and CPZ, the cyclic voltammetric behaviour was determined (see supporting materials), a summary of the effect of functional group on oxidizability is shown in Scheme 2. Two clear SeAR trends emerged. The presence of a chlorine generally increased the difficulty with which the PTZ scaffold undergoes oxidation compared to an additional thiomethyl group. The ease of oxidisability of the free NH analogue (2CPTZ) versus all alkylated analogues explored (0.353 V vs 0.590V for CPZ). With this tentative SeAR in hand, initial optimisation studies for the electrosynthesis of metabolites commenced with the parent scaffold, 2CPTZ via enhanced CV studies. To the best of our knowledge, no CV study of 2CPTZ has been reported (Figure ).