However, in the preparative scale reaction, lower 1b conversions of 72 % were achieved in the first reaction step, and longer reaction times of NfsA (20 hours) as well as further additions of BmGDH were required in the second cascade step (Figure ). This indicates that further optimization is required for the use of the cascade in synthetic applications. Nevertheless, we were able to demonstrate that such a cascade can be used to construct a modular synthesis for indazoles in which the nitrogens linked in the nitrogen-nitrogen bond do not originate from the same molecule. This not only avoids the use of metal catalysts and harsh conditions, but also the use of nitrogen-nitrogen bonded building blocks such as hazardous hydrazine derivatives or azides.