The implication of the identified combinations is that the predictions are potentially synergistic combinations. Real world effectiveness of the drug combination predictions has yet to be determined, but present combinations of drugs that target proteins that are biologically connected to each other through pathways and identify different protein targets at multiple points in pathways. If the team were to repeat this experiment again, we would use a mathematical model, such as a GCA model, that follows the parameters for our specific data and approach. The biological information and how genes are connected does impact synergy. This is shown in the application of methods that share a common route through the pathway and the predicted combinations list is generated.