The minimum inhibitory concentration (MIC) is the lowest concentration of the peptides that inhibited bacterial growth. b Non resistant (wild type) bacterial strain. c Methicillin-resistant Staphylococcus aureus. d Multi-drug-resistant Staphylococcus aureus. c Carbapenem, New Delhi metallo-beta-lactamase (NDM-1)-positive resistant bacterial strain (CRE (NDM-1)). d Multi-drug resistant bacterial strain. e Carbapenem resistant bacterial strain. f Carbapenem-resistant Enterobacterales (KPC-2). g Extended-spectrum β-lactamase (ESBL) (K. pneumoniae ATCC 700603 produces SHV-18). i Results of the assays conducted by NIH. j ND, not determined. The data represents the results of two independent experiments performed in triplicate. Among all the cyclic peptides, those with a higher therapeutic index (7a, 12a, 7b, 15c, 16c, and 20c) were selected for further evaluation against a wider range of fungi. The assays were performed by JMI Laboratories (North Liberty, IA) and subcontracted by the National Institute of Health (Table ). Among all the tested fungal strains, the highest activity was observed against the three tested strains of Blastomyces dermatitidis with MICs = 0.5-4 µg/mL.