Atomate2 is designed to enhance the programmability of computational workflows, offer greater flexibility with respect to different simulation models (including those based on MLIPs), support various workflow execution engines, and accommodate a broader spectrum of materials properties with less re-coding. Atomate2 represents a comprehensive overhaul of atomate, building on its predecessor's successful application in numerous materials design projects and its integral role in the Materials Project (MP) database. In the following sections we detail the enhancements and capabilities of atomate2, emphasizing its improved usability and flexibility, which we anticipate will significantly benefit the next wave of HT DFT calculations.