We evaluated the current method with drugs or drug-like compounds spiked with known amounts of palladium. Presumably because the spiking was performed 4-5 days prior to the assays, the current method underestimated palladium concentrations on average. It is important to note that the method showed the expected relative concentrations of palladium, which may fulfil users' needs in high throughput screenings of palladium scavenging to determine the relative efficiency of the scavengers. With 14 synthetic samples prepared by palladium-catalyzed reactions, we compared the current method with ICP-MS. In this case study, unlike the mock samples spiked with known amounts of palladium, the current method slightly (but not significantly) overestimated palladium concentrations on average. Nonetheless, the relative concentrations of palladium boded well with ICP-MS. We believe these results are remarkable, considering that the samples were not digested. If we develop a protocol to fully restore the palladium reactivity under the reaction conditions through digestion (e.g., microwave digestion ), the accuracy may be further improved.