First, we break down participation and submission statistics for SAMPL8. We received a total of 51 submissions from 11 different groups, with 34 for CB8 and 17 for GDCC. The challenge involved 18 ranked submissions total, 10 of which were for CB8 and 8 for GDCC, and which constitute our primary focus in analysis (see section 3.1). Five groups submitted predictions for both the CB8 and GDCC datasets, providing the opportunity to compare the reliability of these approaches across multiple hosts.