Despite the challenges, MOF-based SERS substrates have proven to be a versatile, robust, and powerful tool, benefiting from the unique properties of MOFs with the exceptional sensing performance of SERS. The interdisciplinary nature of this research, merging chemistry, materials science, nanotechnology, and plasmonics, with other fields like diagnostics, is a thrilling aspect of this field, which holds the potential for pushing one step forward the limits of VOC detection.