The total permeation events for photosynthetic metabolites are aggregated in Fig. , with animations for individual metabolites through a single hexamer shown in SI Animations 2-6. Gaseous compounds (CO2 and O2) have many more observed transitions in our simulations than the anionic compounds, suggesting that gases are more permeable across the synthetic carboxysome shell than other anionic metabolites. Transition . Aggregated metabolite transition events, broken down by metabolite and pathway. Three pathways are possible for each metabolite, transitioning through the hexamer pore (red), the pentamer pore (blue) or the interface between hexagonal or pentagonal protein subunits.