In contrast with this successful determination of the molecular origin of changes in hydration dynamics, the jump model cannot rationalize the slower dynamics observed in DNA at the O2(C) sites on the floor on the minor groove for the GCGC sequence (ρ jump (GCGC)/ρ jump (GGGG) ≃ 1.3), as the computed TSEV factor (with or without ions) predicts the reverse ordering (ρ T SEV (GCGC)/ρ T SEV (GGGG) ≃ 0.8). This shows the limits of our Jump Model which was not designed to work in such confined and restrained environments. Rationalizing at the molecular level the sequence-dependence at slow sites on the DNA minor groove would deserve additional investigation in future work.