Currently, the average cost of the sorbent material used for removing lipids and proteins from plasma or serum is $2.55 per sample when using a 96-well SPE commercial plate, while using dSPE reduces the cost down to $0.16/sample. Moving forward, packing the Sepra particle in a SPE format may provide a more concentrated sample and increased sensitivity, however this would increase sample preparation costs. For large-scale application, using a 96 multichannel pipetting robot for aspirating the supernatant may be convenient and beneficial to the observed precision of LMWM profiles, as it minimizes the risk of disturbing the sorbent pellet after centrifugation by ensuring a steady draw rate from a constant depth across the plate.