It was envisaged that exposure of synthetically versatile acyl 1,2-isoxazolidines to the general reaction conditions would afford diverse amino aldehydes (4a-d), with the formyl handle enabling subsequent (bio)conjugation. Product 4a was generated in 62% yield and it was possible to unequivocally establish the molecular connectivity by single crystal X-ray analysis (Figure , CCDC 2173021). By analogy, the naphthyl derivative 4b, the diene 4c and the p-CF3 derivative 4d were generated by direct N-O cleavage of the starting acyl isoxazolidines (up to 79% yield). To access the C4 series, which may be considered as masked GABA precursors, acyl 1,2-oxazinanes were leveraged as convenient starting materials. However, isolation of the product aldehydes proved challenging and therefore they were generated in situ and used directly in a subsequent transformation.