Given that temperature accelerated dynamics necessarily employ high temperatures, one might hypothesize that CTY-TAD takes a considerable computational effort to identify entropically hindered reactions, i.e. a positive contribution to activation free energy. The analysis of the ĖF data set does not support this idea, as CTY-TAD finds as many reactions as PESmapping with negative activation entropy, i.e. which have a positive contribution to activation free energy (see Tab. 2 and Fig. ).