The inclusion of SEA predictions expanded these interactions to 9711 ones (> 4-fold increase), now comprising 422 and 330 compounds, and for 1047 human and 180 microbial proteins, respectively. This expansion resulted in the generation of new interaction hypothesis for 125 chemical class vs target class combinations with no previously published interactions. Within these combinations, there a total of 1150 new hypothesis for fast, focused tests in uncharted chemobiological spaces. It is worth noting that most of the research in gut microbial metabolites is being focused in GPCRs and nuclear receptors, but here we provide lots of hypothesis for alternative, underexplored target classes like "Enzyme other", "LGIC", "Ligase", "Transferase", etc., in combination with well described or underexplored chemical classes ("Organic acids and derivatives", "Nucleosides, nucleotides, and analogues", "Benzenoids", etc.) In addition, for other 116 combinations the interaction counts have increased, corresponding to 6422 additional new hypotheses for chemical class vs target class combinations with at least one published interaction.