The presence of individual fragments in one case implies that certain molecular structures cannot be generated in another case, which could potentially lead to sub-optimal candidate molecules. To assess the impact of individual fragments (with the weighted amounts of 40% and 16%, respectively) from one case on another, an analysis is conducted on the designed elite molecules across all six runs. It is noteworthy that, on average, about eight candidate molecules designed in the bench-535 mark case will never be generated in the augmented case, because these candidates can only be constructed with the fragments exclusive to the fragment library of the benchmark case.