Figure illustrates representative chemical structures that have been obtained from natural resources collected in the state of Veracruz, which are distinguished by their structural diversity , and their great applicability domain in medicine (e.g. to develop antimicrobial and anticancer drugs), cosmetology (e.g. to develop skincare molecules), nutrition (e. to develop nutraceuticals), agriculture (e.g. to develop biopesticides and insecticides), and many other applications . In the present scientific context, it is possible to establish highly efficient virtual screening protocols using chemoinformatics methods, natural product databases have covered a worldly interest in the past 20 years . Multiple commercial and open-access natural product databases are available as valuable resources for molecular design. It is expected that databases will continue to grow in number and type. For example, focusing their creation on the organization of data and information on natural products based on their reported biological activity, chemical characterization method, geolocation, natural source, commercial availability, etc . Web applications like COCONUT 2.0 (the COlleCtion of Open NatUral producTs) is an an excellent resource freely available at to unify and standardize multiple natural product databases , which facilitates the systematic filtering of multipurpose data useful for chemoinformatic and natural products research.