Despite similarities in the reported yield distribution of NiCOlit and HTE data, the underlying structure of the reaction data drastically differs. In HTE, all possible combinations of reactants and reaction conditions are explored (Fig. ). Due to time and cost constraints, chemists tend to perform a sparser exploration of the chemical space to achieve a faster convergence. Indeed, published reaction data is reported in two categories of tables or schemes: optimization and scope. Optimization refers to the reaction conditions meaning that most parameters except substrate and coupling partner are modified in order to achieve an efficient reaction (vertical dots arrays Fig. ). In a complementary fashion, scope refers to reactions with various substrates and coupling partners under optimized conditions (horizontal cross arrays Fig. ). Scope experiments are performed in order to demonstrate the robustness of the reaction. In the case of NiCOlit, we noticed that yield distribution of optimization data is similar to the HTE yield distribution and that scope data displays a distribution reminding that of Sci-Finder n (Fig. ). Exploiting optimization tables during data extraction allows to bypass the lack of low yields reactions in proprietary datasets, and could offer improved predictive performances.