The synthesis of CPPs has been experimentally challenging due to the strain energy needed to close the ring. Vögtle et al. attempted to synthesize CPPs from macrocycles formed by arene and cyclohexane units to therefore reduce the strain energy of the system. However, the first synthesis of CPPs was afforded only by Jasti et al. in 2008, followed by the first selective synthesis of CPPs by Itami et al. using a modular approach to build [n]CPPs with n≥12. Other successfully strategies (Yamago et al. ) use a square-shaped tetra platinum biphenyl complex as an intermediate to selectively synthesize the [8]CPP molecule. In the above mentioned works, it was possible to obtain CPPs in the milligram-scale, with Jasti et al. producing the first gram-scale synthesis. The smallest CPP synthesized up to day is [5]CPP, which shows the great success achieved so far in overcoming the strain energy.