In order to enable an up-to-date analysis of currently investigated bioactive compounds, we applied the NPFC tool to the latest version of the ChEMBL database (v32, released in 2023; 2.4 million compounds) as described in the experimental section. In the course of this analysis, it was found that the previously described version of the tool erroneously removed FCG duplicates when they were present in the same computing chunk, resulting in a significant under-representation of PNPs. Therefore, we report here the updated numbers for ChEMBL v32, confirming the expected increase of numbers for PNPs. Fig. shows the results obtained for the ChEMBL v32 dataset, deduplicated by InChIKeys of the standardized and racemic structures (2.1 million compounds). Within that dataset, 690,000 PNPs were identified, which is 32% of the listed bioactive compounds. In the analysis provided earlier, 340,000 PNPs had been identified, i.e. the fraction of PNPs in the ChEMBL database actually is significantly higher than previously estimated. In addition, 220,000 natural product like compounds (NPLs) and 39,500 natural products (NPs) were identified (fig. ). These numbers are similar/differ from the previously determined results, where 35,000 NPs were identified; the number of NPLs was not determined in our previous report.