Lastly, results showed that BO is susceptible to noise, and proactive actions are recommended to reduce measurements noise, e.g. by duplicating experiments if possible. On the other hand, BO is more robust to smaller batches, with comparable performance (< 1 log unit) with batches of 48 peptides to full batches (96 peptides). In complement, we observed that more elaborate batch strategies, such as CL batch strategies, that encourage sequence diversity within each batch, perform worse than the simple top-k batch strategy. Pursuing sequence diversity may, in fact, be counterproductive as the molecular landscape is not smooth, but paved with multiple activity cliffs, resulting in missed promising peptide sequences.