To compare predicted and measured on-and off-targets, we use two kinase bioactivity datasets available through KinMap: The Karaman et al. and the Davis et al. datasets on KinMap contain inhibition profiles (K d values) for 38 and 72 kinase inhibitors across 317 and 442 kinases, respectively. The lower the K d value, the higher the binding affinity, which is used as a proxy for activity. We pooled data from both datasets by taking the union of all kinase-ligand pairs. If kinase-ligand pairs have bioactivity values in both datasets,