Recently, a very remarkable DNA nanorobot has been introduced that not only can respond to stimuli but also can do the first act autonomously and remotely to study the mechanical activation of membrane proteins. The challenges in understanding mechanotransduction, which is the conversion of mechanical forces into biological signals in cells have led to presenting the 'Nano-winch', an innovative molecular actuator based on DNA origami, capable of simultaneously manipulating multiple mechanosensitive receptors in parallel. The Nanowinch can exert low-piconewton forces on cell membranes in autonomous and remotely activated modes, which allows for the study of cellular mechanical processes. The article also demonstrates the application of the Nano-winch in observing the opening of a force-responsive gated channel protein in a single-channel bilayer experiment. The Nano-winch is a customizable tool that can be used to explore various mechanotransduction circuits on living cells without requiring instrumentation .