An additional aspect was considered, which relates to the description of the two clusters, namely, the effect of the use of a bigger replicated region. In Figure , we show the CCSD spectra obtained, again for two selected structures, adopting an inner polarizable region of 12 Å polarizable LoProp water molecules both alone and together with an outer nonpolarizable region up to 25 Å of SPC water molecules to mimic bulk-water effects. Clearly, the inclusion of more water at the MM level does not have a huge effect.