To confirm that the host is stable during electrocatalysis, we analysed host 5-functionalized ITO substrates before and after electrochemical measurements (with HGC-bound guest 2). We observed no peak shifts or decreased intensities for the carbon, phosphorus or sulfur signals pertaining to host 5 between the two measurements (Figure ) indicating that there is no oxidation on any part of the host structure. To demonstrate the stability also under challenging conditions for most classically anchored catalysts, CV cycling at pH 10 under strong oxidative bias was performed (Figure ), showing only a slow decrease of the guest redox features. Analysis of the sample surface by XPS showed a modest decrease of carbon, sulfur and phosphorus related to surface-bound 5 (Fig S36 ), indicating that the majority of the surface binding sites remained stable under such harsh conditions on the order of hours. The stability of host 5 under catalytic conditions implies the potential use of this immobilization strategy for different molecular electrocatalysts, with the option of electrode recycling. This also implies that the stability of the anchoring group for surface binding can be decoupled from catalyst design and separately optimized on the host, which presents a promising new approach to developing and improving new ways of coupling molecular electrocatalysts with different electrode surfaces.