MITE is designed to contain the (meta)data to allow semi-automated creation of entries in Rhea whenever the information required for this is available. Vice versa, entries in Rhea can be used as starting points for MITE entries, providing validated reaction pairs, which only need to be supplemented by the reaction SMARTS, reaction metadata, and references to the genomic context of the enzyme. This compatibility-by-design not only facilitates data exchange, but also fosters community building and collaboration between submitters to either of the two databases.