However, there was only one distribution in this case, differently than what was observed for Dhaykol at similar API concentration (Figure ). Above 26.67% (w/w) of BTB, the Figure shows the relationship between BTB concentration and mean score values for each map. There was a linear increase of score values until 15% (w/w). The score values did not increase after 26.67% (w/w) BTB. Thus, when BTB concentration was higher than 26.33% (w/w) an API overload seemed to occur, since a major part of BTB was the surface instead of mixed with the excipients. However, because of the good solubility with the liquid excipient, there were no clusters in the chemical maps. Instead of this, BTB went to the sample surface and homogeneously spread out. This characteristic affected the calculation of DHI, which showed lower values for these samples. Therefore, it is of utmost importance during the model building to compare the DHI with the visual evaluation of the chemical images. While the sample with 26.67%