Experimental data in ethanol at 298K (log(S EtOH,exp )) are available for 44 solutes. These data are used in Eq. 3, together with the model predictions of ∆G solv,298K , to calculate the solid solubility of those solutes in 76 different solvents for a total of 785 datapoints. A comparison between the model predictions and experimental measurements is given in Figure (right, red). The overall predictions for log(S X,298K ) improve to a RMSE/MAE of 0.29/0.16 log(mol/L). Using experimental data in other common solvents (methanol, acetonitrile, ethyl acetate, and toluene) as a reference gives similar results that are presented in the supporting information (Figure ). In Figure , values for log(S X,298K ) calculated using log(S EtOH,exp ) are indicated in red. The calculated solid solubility shifts towards the parity line compared to the calculations that use the model predictions for log(S aq,model ). In general, using experimental data for the solid solubility in one solvent as a reference in Eq. the same solute. However, one should note that the experimental data used as a reference often originate from the same source as the other experimental data that are used to evaluate the model performance. As a result, some consistent errors specific to the experimental unit or procedure are compensated for and the model performance might be overestimated. This is demonstrated in the supporting information (Figure ) by using experimental aque- ).