As SMACs diffuse into the bilayers they experiment their own conformational changes. Figure describes the SMACs end-to-end distance as a function of time for different setups: (i) yellow and red lines correspond to yellow and red intra-organelle SMACs as shown in top-left and top-right snapshots at t=0 and t=3.5µs respectively and (ii) purple line corresponds to a (purple) SMAC solvated in water with no bilayers present. Remarkably, the yellow SMAC that remains outside the bilayers keeps a globular conformation (yellow line) just like the purple SMAC solvated in water without bilayers (purple line). On the other hand, the SMAC that penetrates the membrane (red molecule) and locates itself below the lipid-water interface, extends to its full length ≈9nm (red line) at t≈3.5µs.