Single-atom nanozymes (SANs), a type of nanozyme characterized by atomically dispersed active sites, process ultrahigh enzyme-like activity and excellent chemical stability, endowing them with unique catalytic performance . Recently, Fe-based SANs with dispersed Fe atoms, known as Fe-N-C-based SANs, have shown superior peroxidase-like characteristics . The excellent catalytic performance of Fe-N-C SANs for H2O2 makes them widely used in various sensor applications, such as the detection of glucose, uric acid, lactate, herbicide and butyrylcholinesterase, as reported in our previous studies .