Organogenic elements in this period also grew in diversity and number of compounds, and this not only occurred for the typical organic chemistry combinations of elements (CHNO, CHO, CHNOS and others reported in ), which spanned most of the chemical space of those times , but also by their combination with lanthanoids (SI Fig. ), as evidenced in the production of organometallic compounds, as well as halides and oxides (). Although compounds of noble gases were reported as early as 1952 for Kr and Xe , the trio {Ar, Kr, Xe} became a family only by 1958 through the synthesis of some of their clathrates with formula A*2B*17H 2 O, where A is one of Ar, Kr, Xe, and B is one of the organic solvents: acetone, methyl dichloride, chloroform, and carbon tetrachloride . Similarities among these elements were further strengthened by the synthesis of some of their fluorocompounds . The inclusion of Ne occurred in 1997, through the production of atomic clusters of noble gases . This is yet another example of how known periodic patterns oriented the research in the chemistry of elements.