However, there still is not an omnipotent chiral ligand or catalyst thus far because the slight changes in geometric, steric and electronic properties of chiral ligands or catalysts can cause dramatic variations of reactivity of substrates and enantioselectivity of products. Recently, we have developed a new kind of axially chiral cyclo-[1,1'-biphenyl]-2,2'-diol (CYCNOL) cores with adjustable dihedral angles by varying the chain length of the full-carbon 6,6'-tether (left one in Fig. ) , and CYCNOL-based phosphoramidite and diphosphine ligands and chiral phosphoric acid catalysts were effectively developed. Here, we design a novel kind of adjustable axially chiral [1,1'-biphenyl]-2,2'-diol (BIPHNOL) cores (right one in Fig. ). As shown in Fig. , our imaginations are as follows: variation of 2,2'-substituent groups would adjust types of chiral ligands and catalysts, variation of substituent groups at the 3, 3', 5, 5'-positions would adjust steric and electronic properties of chiral ligands and catalysts, and variation of 6,6'-substituent groups would adjust dihedral angles, steric and electronic properties of chiral ligands and catalysts.