This study provides insights into the performance of different conformation generation engines and their impact on global minima identification and accurate CCS prediction. Moreover, the findings will contribute to the development of more reliable computational workflows for conformational search and related applications in drug design. Based on our present observations conformational search tools have significant room for improvement for gas-phase ensemble prediction. To help in fostering improvements we created the open-source GPCL database, which currently contains the conformational ensembles of 20 small molecules.