Biased MD simulations have been developed to calculate the kinetics of molecular events, e.g., ligand Gaussian accelerated MD , metadynamics , and steered MD (SMD) . Here, we focus on the SMD simulation. It uses an external force applied to a system to enhance physical processes, such as molecular dissociation events. Thus far, several variants of the SMD simulation have been devised: dissipation-corrected targeted SMD , adaptive-steered MD , and random acceleration MD . For further details, Katya Ahmad et al. have recently published a comprehensive review .