This study investigates the activity of 6-gingerol against key Candida albicans fungal proteins involved in specific biological functions, including Sterol 14-alpha demethylase, which is responsible for sterol biosynthesis ; N-myristoyltransferase, essential for protein biosynthesis ; Aspartic protease, a virulence factor ; Geranylgeranyltransferase type-1 subunit alpha, critical for metabolite synthesis ; and Dihydrofolate reductase, also involved in metabolite synthesis . By interfering with these crucial proteins, 6-gingerol may inhibit fungal growth, disrupt metabolic pathways, and reduce virulence, showcasing its potential as a novel antifungal agent.