To get more nuanced insights into the impact of the acquisition functions in the capacity to traverse the chemical space, we analysed the physicochemical properties of the acquired hits over iterations. Different acquisition functions steer a screening experiment towards populations of molecules with different physicochemical properties than the starting set. An example experiment is shown (Fig. ), where, starting from the same set of molecules, the physicochemical properties of the acquired hits (e.g., total polar surface area and molecular weight) will progressively move towards different distributions over screening cycles based on the chosen acquisition function. This indicates that different acquisition functions can discover distinct chemistry, as captured by the analysed physicochemical properties.