Given the nature of using distributions to analyze the molecular binding interaction of a ligand to a protein it is appropriate to comment on the thermal statistical interpretation . Many protein ligand experimental IC50 results, correlated with GOLD scores as well as energy estimates from AutoDock and AutoDock Vina, show that a GOLD PLP score difference of 6.5 translates to about 1 kcal, with 1 kcal generating a x10 in binding affinity.