The O 2 -GEN framework offers several key advantages over existing methods. The incorporation of a 3D pre-trained backbone allows the model to capture the complex structural relationships and electronic properties of OOMs, leading to more novel generation and accurate predictions. VPs method provides a fast and maneuverable way to generate molecules, endows the flexibility of O 2 -GEN in both global and local generation modes, and provides researchers with a powerful tool for fine-tuning molecular properties. This is particularly valuable in the context of organic optoelectronics, where small structural modifications can have a profound impact on device performance. The ability to generate molecules with specific properties, such as precise energy levels or absorption maxima, opens up new possibilities for the design of tailored materials for specific applications.