In this proof-of-concept study, we have presented the first exploration of incorporating an organometallic moiety in PROTAC linkers to act as a molecular hinge enabling dynamic conformational changes. By introducing ferrocene into homo-and hetero-PROTAC systems (FerroTACs), we demonstrate its potential to enhance protein degradation by facilitating the rational design of molecular chameleons and improving cellular uptake. Conformational analyses using NMR spectroscopy indicate the shielding of amide protons through IMHB and intramolecular interactions in an apolar solvent, supporting our hypothesis that the flexible rotation of ferrocene might enable dynamic conformational changes and fostering more compact conformations that likely enhance cellular permeability. Cellular studies show that FerroTACs are well-tolerated in cellular contexts and effectively induce target degradation via a PROTAC-like mechanism, with degradation activity comparable or enhanced relative to reference analogues. The NanoBRET VHL-engagement assay further validated the improved cellular permeability, and the compounds' lower dependency on efflux mechanisms was shown. This study thus highlights ferrocene as a versatile and innovative chemotype for PROTAC design, providing benefits in linker optimisation, conformational flexibility, and improved permeability. Future work will explore the potential of this strategy for difficult-todegrade targets, such as those with low PROTACtability, and investigate its applicability to additional E3 ligase-target combinations, to expand the scope of bifunctional degrader. Additionally, significant emphasis will arise on expanding linker chemical space by incorporating alternative metal-based systems and advanced designs that might allow control of the cis-trans conformational equilibrium, unlocking future applications in chemical biology and bioconjugation.