Second stage: screening was carried out with the online service admetSAR 2.0 to obtain the pharmacokinetic properties, acute oral toxicity, as well as the potential liver and kidney damage of the molecules chosen in the first stage. At this point, the molecules that presented adequate parameters of bioavailability, maximum two inhibitory interactions of the CYP450 . The three-dimensional structure of the crystal of the enzyme trypanothione reductase of Trypanosoma cruzi cocrystallized with its endogenous ligand trypanothione and the flavin adenine dinucleotide coenzyme (FAD) was downloaded from the Protein Data Bank repository with the code 1BZL . The preparation of the protein was carried out with the Molegro Virtual Docker program , water molecules were removed, druggable cavities were detected, and the catalytic site of the A chain was selected for docking molecular studies with a search sphere of 10 Å radius, with the coordinates X: 24.21, Y: 9.46, Z: -4.01 and a grid of 0.20 Å.