wire and introduced using an intravenous catheter ; only limited examples have been reported in which, as is true for continuous glucose monitors , such devices have been adapted to microneedles suitable for performing measurements in the dermis . And while these demonstrations represent a significant advance in in vivo molecular monitoring, all prior reports have been limited to rats, the overwhelming majority of which were anesthetized during study. It is unclear how well such devices function in ambulatory animal studies, and even more uncertain in human subjects as no human data has been reported thus far.