Looking at the cancellous bone, macrophages do not have a clearly defined role in healing, however their interactions with osteoblasts suggest an indirect yet significant impact. Those interacting macrophages labeled as osteomacs reside in bone lining tissues in a subsurface anatomic location (within three cells of the bone surface). In sites of bone remodeling, they form an organized "canopy" structure around the osteoblasts, enhancing mineralization and performing "maintenance" of mature osteoblasts. Osteomacs are recognized for their role in anabolic bone modeling, specifically associated with sites of intramembranous ossification .