It refer to a domain at the C-terminus of mitochondrial fission factor (Mff) and FATE1 as Mff-like (IPR039433). The presence of this domain is needed for Mff to interact with the dynamin-related GTPase Drp1, which helps mitochondria split. Conversely, FATE1 is responsible for regulating the ER-mitochondria distance and mitochondrial Ca2+ uptake.