Another notable feature of SAA is its sitespecific adsorption to the HSs, which is most apparent in the SOM III case when comparing the contribution of the sulfonamide group (blue) across different functional groups. The site-specific adsorption is characterized by selective interactions of the aromatic ring or sulfonamide group with specific functional groups or sites within SOM. The ratio r = E int,sulf. /E int,arom. of interaction energies of the sulfonamide group compared to the aromatic part with the amino group (gray + orange) in SOM III is as follows for the five depicted functional groups, quinone, acid anhydride, aromatic, phenol, and carboxylate: 1.89, 1.94, 0.90, 1.88 and 2.36. This indicates, for example, a stronger attraction of the sulfonamide group to the negatively charged carboxylate groups (r = 2.36), and a higher attraction of the aromatic ring to the aromatic parts of the HS molecules (r = 0.90). This feature of SAA in the SOM interaction was reported by theoretical and experimental investigations and is reproduced by the coarse-grained model, thus further validating the present parameters.