HRMS analysis were conducted on a Waters XEVO G2-XS quadrupole time-of-flight (QTof) mass spectrometer instrument. Mass to charge (m/z) ratios are shown in Daltons. LCMS analysis has been carried out using one of the following methods:  10 min Formic: Ionisation mode: Positive Electrospray. Acquity UPLC CSH C18 column (100 mm x 2.1 mm, 1.7 μm packing diameter) at 50 °C, 0.8 mL/min flow rate. Gradient elution with the eluents as water containing 0.1% volume/volume (v/v) formic acid and (B) MeCN. The UV detection was a summed signal from wavelength of 210 nm to 350 nm. Injection volume: 0.2 µL.