However, it is important to note that highly accurate self-docking does not necessarily imply accurate binding free energies, nor does it guarantee that the relative binding free energies between the native ligand and other new ligands will be precise. Nevertheless, obtaining highly accurate self-docking results is an encouraging indication of the reliability of the docking protocol. The table below presents self-docking results for all 16 systems using both the vinardo and dkoes scoring functions.