To showcase the model's potential, it was applied to the NORMAN SusDat database. For this, the 2DAPC and reduced PubChem fingerprints for a total of 91737 chemicals with a molecular weight below 1000 Da from SusDat were calculated. These fingerprints were then used to calculate the leverage of each chemical with the RPLC classifier training set, as explained in the next section 'Applicability Domain Calculations', and to apply the RPLC classifier model to each of the SusDat chemicals. To visualize the coverage of each class (i.e., 'inside', 'maybe', and 'outside' the RPLC subspace), the molecular weight was plotted against the XLogP, which were obtained from the descriptor calculations of PaDEL.