This framework has the potential to drive significant advances in fields where activated events exploration play a central role, including heterogeneous catalysis, reactive surface rearrangements, enzymatic catalysis, and asymmetric catalysis. Furthermore, it may offer insights into fundamental scientific questions such as prebiotic chemistry-including the Urey-Miller reactions-as well as environmentally and technologically relevant processes, including atmospheric and combustion chemistry, and pyrolysis. Likewise, it can be applied even to non-chemical activated events such as ligand-protein unbinding and polymorphic transitions in crystals, where new phases are not known a priori.