From a design perspective, it is desirable for several combinations of side-chain and linker to be compatible with a given ligand body. To provide a metric for whether this design flexibility exists for the surveyed systems, the percentage of (un)stable ligands that were only (un)stable with a specific linker or side-chain were calculated (Table ). For all side-chains and linkers, the unique (un)stable rates are <2.5%, with most approaching 0%. This suggests that the selection of these components is relatively flexible and that the overall stability trend for a given ligand is more strongly constrained by the body chemistry than the side-chain and linker choices.