Rubia cordifolia is one of the species on the genus of Rubia. which comprises 450 genera and 6500 species and includes trees, shrubs, and, infrequently, herbs; it falls into about 70 species distributed widely around the world, such as Western Europe, Northern Europe, Mediterranean Coast, Temperate Asia, Africa, Himalaya, as well as the regions from Mexico to Tropical America . Rubia cordifolia is a flowering plant distributed widely around the world, including the western and northern parts of Europe, the Mediterranean coast, temperate regions of Asia and Africa, as well as the regions from Mexico to Tropical America . It is a perennial, prickly climber with a stem, growing up to 12 m long. Leaves are highly variable, ovate lanceolate, 5-7 nerved, 2-10 cm long and 2-5 cm broad, occurring in whorls of 4-6.