Despite the vast array of MOF structures and the virtually limitless modifications possible, our analysis of the dataset generated for this review, reveals that just 38 different MOFs were explored as/in SERS substrates, but only 10 of them served in 70% of the reported works, as summarized in Figure . The most frequently used MOF appears to be ZIF-8, probably due to its straightforward (and versatile) synthesis, robustness, and hydrophobic microporosity, which makes it ideal for the adsorption of non-polar molecules. This importantly highlights the incipience of the field and the still unexplored potential that it represents.