The introduction of fluorine into target molecules significantly alters their physichemical and biochemical properties, including dipole moment, hydrogen bonding, lipophilicity, and metabolic stability . Currently, approximately 20% of pharmaceuticals and 30-40% of pesticides on the market contain fluorine. Among the various organofluorine entities, trifluoromethyl alkanes and gemdifluoroalkenes are particularly important and commonly found in bioactive molecules (Figure ) .