Of the 94 bile acids included in the targeted method, 35 were quantified in the CSF samples (Table ). An overview of these results is given in Figure , significant results are marked with an asterisk. The identification of BAs in CSF implies a possible source either through systemic circulation uptake or local synthesis within the brain . While a previous study quantified BAs precursors in the CSF of AD patients , to our knowledge this is the first time that BAs are quantified in CSF in the context of MCI and AD.