Aiming to achieve precise tumor therapy, the combination of multiple responsiveness in a single hybrid hydrogel has been also reported. As an example silica-coated Fe3O4 NPs grafted on GO were used as magneto and photothermal agents when incorporated within a thermosensitive PNAGA matrix (PNAGA-Fe3O4@SiO2-GO) containing also Dox-loaded MSNs (Figure ). The efficient conversion of magnetic field and NIR light into heat, locally increased the temperature allowing: permission. Copyright 2020 Elsevier.