Two mycotoxins with high contamination levels, ZEA and OTA, were selected as case studies. The complex structural features of ZEA and OTA lead to various biotransformation possibilities under the action of enzymes. Therefore, we comprehensively predicted the potential toxin biotransformations of OTA and ZEA based on reaction rules in ToxinDB (Fig S6 ) 13 . To rationally select the optimal detoxification reactions for ZEA and OTA detoxification, we evaluated the feasibility, safety, and economics of these enzymatic biotransformations (Table ) and finally selected lactone bond hydrolyses and amide bond hydrolyses for the detoxification of ZEA and OTA, respectively (Tables and).