As the described H-bonds might be crucial for explaining differences in drug loading capacities, these were analyzed in more detail. The ratio between CUR-B and CUR-A H-bonds is highest for the case of the A-pPrOzi-A systems (Figure ), in line with higher drug loadings within the core (see above). RDF analyses provide further insight into the differences between the systems regarding these Hbonds (Figure ). Lifetimes between systems containing the same A or B blocks can be expected to differ, as changes in hydration, local drug concentration in core and shell areas and the size of the interfacial area between A and B blocks (where drugs are in contact with different types of repeat units) depend on the structure of the whole ABA-triblock copolymer but affect disruption of the investigated H-bonds. In conclusion though, the findings for the B blocks (Figure ) corroborate previous fluorescence upconversion studies, in which greater interaction lifetimes were also detected for pBuOx-based structures, which were interpreted as a result of lower CUR mobility. Our MD experiments corroborate that micelles bearing pPrOzi hydrophobic domains with a much higher LC actually establish weaker interactions with the cargo than pBuOx.