Natural products (NPs) possess structural properties that confer them a privileged status in drug discovery. However, such properties also entail significant challenges for NPs chemists . NPs are characterized by more sp 3 carbons, chiral centers, or oxygen atoms than synthetic compounds, and while explaining their relevance to biological targets and higher hit rates in drug discovery screening programs, this complexity also explains the difficulties encountered in their chemical synthesis . At the natural extracts (NEs) level, the complexity arises from the vast array of structurally diverse compounds, each at varying concentrations, constituting the NE mixture. This complexity poses a significant challenge in determining the precise composition of NEs.