In previous work 11 we demonstrated how surfacesolvent interactions have the ability to affect the surface roughness as well as the solvent behaviour at the crystal surface, which, in turn will play an important role in the processes of incorporation or detachment of growth units from the crystal surface. Moreover, internal conformational rearrangements of the solute are typically present, and can be dependent on both the crystal face and the solvent. The combination of these effects has an impact on the mechanism of detachment, and on the role of conformationally or orientationally disordered configurations along that pathway. To understand more about the role of the non-crystal configurations found through the analysis of the FE profile, illustrated in Fig. , the detachment trajectories are investigated in more detail.