This work is computational and no lab work has been done on these molecules, unlike with Nirmatrelvir and related molecules . There are good similarities of the 2 proposed molecules with Nirmatrelvir structurally and in interaction; these molecules occupy the same location in the cavity as Nirmatrelvir and extend to other parts of it. The 2 molecules, and others in the presented set, appear ADME compatible, synthetically viable, editable without drastic change in docking, and soluble in different media as the other drug molecules in this work. Computationally, these are more Mpro target region specific than Nirmatrelvir, with increased binding, and low to mid-range binding to the liver enzyme CYP 3A4. There is a significant interaction energy increase and a gap reduction between Nirmatrelvir to Mpro versus CYP 3A4 from -2 kCal to zero.