In a recent all-atom MD simulation study, Boccalini et al. used enhanced sampling methods to investigate how the conformational ensemble of an RNA hairpin is reshaped in a crowded peptide environment that mimics a biocondensate . RNA secondary structure is substantially destabilized in the condensate and extended non-native conformations are adopted. The driving forces for this conformational rearrangement are the preferential solvation of the RNA nucleobases through hydrogen bonds and stacking interactions with the surrounding peptides, which can be modulated via the peptide sequence, e.g., arginine-rich versus lysine-rich peptides [66].