In order to identify and differentiate the potential influences of Chem-I scrambling from EIMS, it is not trivial to identify if an increase in signal comes from molecules produced from the expected reaction, or if it is due to a fragment formed by Chem-I scrambling in the MS ionization chamber. Approaches to help distinguish between these effects can be varying the operation conditions (e.g., temperature, pressure), or composition of the reaction system (e.g., replacing reactant component with inert component). Also, by using the proper benchmark experiments, one should be able to get a relatively clear indication of whether Chem-I scrambling is involved in EIMS and if so, how much Chem-I involvement needs to be considered.