On the other hand, the pipeline-ascent approach should be used if only structural diversity is needed. This approach receives the lowest Δabins in the bins test. Finally, the pipeline-mix approach should be used if the user wishes to avoid re-optimizing duplicate structures and want to obtain global minimum structure with less computational resources. The pipeline-mix approach with x = 0.8 and Q = 0.2 outperforms all other approaches in terms of the overall parameter and is chosen as the default setting for the clustering approach pipeline in CONFPASS. ). We recommend using the pipeline-mix approach with x = 0.8 and Q = 0.2, the default setting for CONFPASS. This usually gives a distribution of low energy conformations and also finds the global minimum conformation quickly.