Ritonavir's use in blocking the metabolism of other drugs is well known. However, its large effect of 'stuffing the waste basket until full' of CYP 3A4 (and other CYP liver enzymes) so that that a molecule can not be cleared by the liver has the disadvantage of blocking a variety of normal liver functions and of other drugs/small molecules. This a reason that the drug Paxlovid is FDA approved only for high risk groups, i.e., those individuals with predisposition to severe Covid-19, who can accept the risk of Ritonavir. This disadvantage could be eliminated or alleviated by finding other potential small molecule candidates that don't require Ritonavir or other drugs to inhibit ordinary bodily function. A single node of 64 cores with a total of 128gb of RAM was used at the GACRC for the Ligand GA calculations . The total computing time of Ligand GA was ~150 hours with 33 iterations of the Ligand GA genetic algorithm. In order to understand the complexity consider 30 non-isomeric molecules each with 128 stereoisomers. In the Ligand GA fitness function, the non-isomeric molecule is expanded onto all stereoisomers, each of which have to be docked. The fitness function included ADME penalties.