The supporting information file contains comparison between the training simulations and multi-eGO ones for all the showed systems, extended convergence plots for all the TI and VMetaD calculations performed, the representation of binding and unbinding pathways for LYZ:BNZ, the e0 selection details for SRC:DAS, SRC:PP1, and Aβ42:10074-G5; supporting tables with the parameters for all the TI performed on the four systems. Finally, we added 4 movies showing the binding events from multi-eGO simulations in the four complexes.