Additionally ). Interestingly, D was one catalyst that was not on the Pareto front, only close to it, but our kinetic analysis highlights its superior performance, emphasizing the limited predictive capabilities of a reaction-energetics-only screen in SACs. Full kinetic screening of candidates might therefore reveal even better SAC candidates that are not on the reaction energetics Pareto front. Furthermore, our investigation reveals that the relative energetics and energy spans associated with methane oxidation for our selected codoped SACs, C and D, are comparable to the computed energy spans reported in macrocyclic molecular complexes 5 and metal-organic framework nodes . Given the favorable reaction energetics, kinetics, and TOF of C and D, we conclude that C and D are the most promising codoped SACs for methane-to-methanol conversion and merit further experimental exploration.