efficiently with excellent e.r. under milder conditions (Fig. , entry 6). After the optimal reaction conditions were identified, the robustness of the method was evaluated (Fig. ). Overall, very good yields and high enantioselectivities of 99.5:0.5 e.r. were obtained irrespective of the substitution pattern at the amide substrate or the 4-hydroxyalkynoate tolerating also heterocyclic systems . In addition to the highly selective formation of the chiral C-N axis, spirocyclic motifs could also be efficiently integrated . The robustness of the enantioselective cobalta-electrocatalysis was mirrored by enabling the desymmetrization of phosphinic amides under slightly altered reaction conditions (Fig. ). The electrocatalysis proved to be versatile and enabled different enantioselective transformations. The bidentate ligand L1 thus allowed for the enantioselective dehydrogenative C-H etherification and a variety of acyclic chiral phosphinic amides 44-47 was obtained with high enantioselectivities (Fig. ). Besides C-O formation, desymmetrizations were also achieved by C-H/N-H activation for alkyne annulations. In addition to internal alkynes (Fig. , 49-51), terminal alkyne phenylacetylene could be used, and the product 48 was isolated with high enantio-and regioselectivity. Moreover, the cascade alkyne C-H/N-H activation with 4-hydroxyalkynoates occurred by C-C, N-H and C-O formation, delivering various fused polycyclic P-stereogenic compounds 52-59 with high enantiomeric purities (Fig. ), while spirocyclic scaffolds with variable ring sizes were assembled in an efficient manner . The reactions proceeded not only highly stereoselectively, but also with outstanding regioselectivities furnishing a single regioisomer. The absolute configuration and connectivity were unambiguously established by means of X-ray diffraction analysis (Fig. ). It is noteworthy that the cobalta-electrocatalysis could be performed by renewable forms of solar energy using a commercially available photovoltaic cell (Fig. ). These findings highlight the fluctuation robustness and hence the potential towards coupling with the HER for a decentralized GHE.