Having ruled out limitations specific to the membrane or WALP models, we are left to conclude that the pattern of Martini 3 protein-membrane affinities is offset in a way that favors the adsorbed state vs the TM state, while possibly also lowering the transmembranar-to-adsorbed energy barrier (the point when one of the peptide's polar ends is dragged across the hydrophobic bilayer core). Note that the same ejection behavior would not result from just the lowering of the energy barrier: were this the case, WALPs would as easily come back to the supposedly more favorable TM state, which is a transition we never observed (Figure ).