Organism names and HGNC gene symbols were mapped on accession codes from the Papyrus version 05.5 protein table. Moreover, the proteins' taxonomy was retrieved and mapped for all unique UniProt accession codes using the UniProt API via the UniProtMapper package. The two Escherichia coli strains present in the dataset were aggregated under one single Escherichia coli organism. The number of variants and bioactivity data points were subsequently calculated at different taxonomy levels.