Figure (a) amIGM maps with different 𝛿𝑔̅ inter isovalues (bolded texts) showing the average intermolecular interactions of a solvated phenol and aqueous environment during a period of MD simulation. The phenol and all waters in the simulation box are defined as the two fragments for the amIGM analysis. 𝑠𝑖𝑔𝑛(𝜆 ̅ 2 )𝜌̅ is mapped onto the 𝛿𝑔̅ inter isosurfaces using the same coloring method in Fig. but with range of -0.05 to 0.05 a.u. Reprinted from Ref. with permission. (b) mIGM map for a randomly selected frame from the MD trajectory, waters are shown in transparent style if any of its atom is within 3 Å of the phenol.