While a large number of transforms may give power to a retrosynthetic toolwhich after all is intended to provide synthetic route suggestions for any molecule a user may submitthis is entirely unnecessary and was in fact undesirable at the inception of SAVI as we were looking for well-established chemistries that are easy, reliable, safe, high-yield etc. We therefore initially chose just over ten transforms from the knowledgebase with an emphasis on ring-forming reactions (Table ), as well as to provide a test set for implementation of the CHMTRN/PATRAN parser, development of the SAVI algorithms, and initial proof of principle of the feasibility of the entire approach. We used the internal quality annotations in the transforms (such as TYPICAL*YIELD, RELIABILITY, CONDITION*FLEXIBILITY etc.) to filter for overall "good" transforms. We focused on transforms that create novel molecules by making significant new bonds, some of which encode ring-forming reactions. In the SAVI production runs that created the data described here we did not use functional group interchange (FGI) transforms, including the newly written Balz-Schiemann Fluorination (ID 6030) and Nitro Reduction to Primary Amine (ID 6040), which have significant expansion potential, being applicable to 96,314,519 and 89,415,518 of the 1.75 billion SAVI products, respectively. They, and potentially other FGI transforms from the original LHASA transform set, may be used for future broadening of the SAVI database.