The electrostatic interaction in the SCME model is described in terms of the intrinsic molecular moments of the isolated molecule and the response of the molecule due to the electric field originating from the other molecules (or other external perturbation). Each molecule i is ascribed, in the global reference frame, a dipole (µ i ↵ ), quadrupole (✓ i ↵ ), octupole (⌦ i ↵ ) and hexadecapole ( i ↵ ) moment tensors characterizing an isolated molecule, plus a dipoledipole (↵ i ↵ ), dipole-quadrupole (A i ↵, ) and quadrupole-quadrupole (C i ↵ , ) polarizability tensors describing the e↵ect of local electric field due, for example, to neighboring molecules.