In summary, the OSDAs with cyclic structures or shorter alkyl chains are more likely to stabilize in pockets at the corners of the pores. In contrast, the OSDAs with long chain groups tend to have a space-filling role and steric effects are dominant. When OSDAs bearing long carbon chains are used (more than five aliphatic carbons per side chain), layered structures are obtained as the OSDA partially fills the pores as well as the interlayer space. In addition, MOFs with interpenetrated structures appear to be obtained when diamines are used as OSDAs.