On the contrary, the SARS-Cov-2 Mpro showed a significant perturbation after about 10ns when complexed with lamellarin K , which corresponds to the detachment of the ligand from the pocket due to instability. This was also confirmed by visualizing the trajectories using virtual molecular dynamics (VMD) and investigating the ligand's RMSD, which showed extreme instability and substantial deviation, indicating the loose motion of the ligand in the system unbounded to the protein . Regarding any further analyses, the lamellarin K ( )-Mpro complex will be ignored.