In other words, polarizable force fields add additional complexity to the physical model used in describing these systems, potentially providing additional accuracy but with additional computational cost. However, for some host-guest systems, this may be particularly important for several physical reasons. First, these systems often exhibit strong electrostatic interactions in a buried, relatively hydrophobic environment, meaning that the precise degree of polarization and environmental shielding may be a key determinant. Polarizability may affect the strength of charge-charge interactions, and may strongly modulate the shielding effect of the environment. Additionally, the hydrophobic effect can be a key determinant of binding, and this is also likely strongly modulated by polarization of the water and host.