Nitrile and amide groups are all the key structures of natural products, biologically active molecules, agrochemicals, dyes, or materials science. In the past decade, nitriles were obtained from the conversion of oximes via dehydration, as well as substitution reaction involving cyanogen reagents. In addition, carboxylic acid derivatives and amines are traditionally applied for the synthesis of amides via a condensation reaction, which needs to happen in harsh conditions. Unfortunately, most synthesis were performed with toxic reagents and cumbersome experimental operation. Though the great progress made in the generation of nitriles from aldehydes and have well applied in the wide substrate scope of aldehydes, there are few suitable methodologies for the synthesis of both nitrile and amide from aldehydes and ketone respectively. Compared with traditional nucleophilic substitutions by using HCN or metal cyanides as well as recent popular oximation-dehydration strategy with the prepared reagents or additional alkali we designed an environmentally friendly alternative using triphosgene. This reagent is cheap and used without further preparation. In a recent report, the reaction site of oxime was used in the chemical detection of phosgene. Since then many researchers reported the synthesis of nitriles or amides from various oximes with phosgene or its substitutes (triphosgene and diphosgene). But most of these applications suffer from the effect of toxic phosgene overflow at alkaline conditions (such as adding TEA in the reaction system) and narrow substrate scope. Phosgene and its substitutes are important industrial feedstocks used in the productions of polyurethanes, polycarbonates, pharmaceuticals, insecticides, and aniline dyes. On the other hand, phosgene, and diphosgene are highly toxic lung irritation effects even at low conversions, for which have been used as chemical warfare agents (CWAs) during World War I and World War II. As a substitute for phosgene, triphosgene is non-volatile, and widely used in chemical synthesis. With the increasing demand for fossil resource-derived chemicals and fuels, the viewpoint of developing those alternatives from the catalytic transformation of renewable biomass has received global concern. Among the alternatives from biomass valorization, the production of 5-hydroxymethylfurfural (HMF) from hexoses is a versatile platform for the synthesis of furan-based chemicals such as furyl diamide, diamidine, diimidate, and diformylfuran. Therefore, oxidative depolymerization of lignin and lignin model compounds can obtain aromatic aldehydes and ketones such as vanillin veratraldehyde, acetovanillone, acetosyringone, and syringaldehyde. To further demonstrate the utility of our protocol, we used our one-pot strategy for the efficacious synthesis of 2,5-dicyanofuran from biomass-derived 2,5-diformylfuran. Besides, we also got fruitful nitriles and amides from lignin-derived monoaldehyde and aromatic ketone. Especially, capsaicin analogs such as nonivamide, capsaicin, and phenylcapsaicin (Figure ), as typical capsaicinoid compounds, which show prominent antiinflammatory, and anti-cancer properties, have been widely applied in cancer prevention . Capsaicinoids were usually prepared from vanillin by first reducing vanillin oxime to obtain vanillylamine and then further reacting with acyl chlorides (Schotten-Baumann) to form the final products. Figure . Examples of biologically active capsaicinoids. Alternatively, the synthesis of capsaicin analogs was to use our approach to prepare the intermediate 4-hydroxy-3methoxybenzonitrile (P1c-22), which can be easily used to obtain vanillylamine by hydrogenation reduction , with which reacted with different fatty acid derivatives to form the amide bond and generate the corresponding capsaicinoids, as showed in Figure .