A potential realistic drug-like molecule cannot be found by docking score, i.e. binding interaction, alone. There are other considerations, such as tolerability in the body, synthesizability also at scale, and interactions of the molecule in the course of ingestion/injection towards the target protein(s), transport in the blood system, permeability in different media and through membranes, and observance of excessive binding to proteins in the biochemical pathways. ADME heuristics guided by Lipinski's Rule of 5 and others , are a good measure of many of these, and almost all orally ingested small molecule drugs satisfy these guidelines. In addition to ADME requirements from Lipinski's Rule of 5, other constraints can be included from amino acid specific localization of ligand atoms, individual atomic binding scores, chemical fragments and substructure, pseudo-atoms, hydrogen bond constraints, etc… Only ADME constraints are used in conjunction with GOLD PLP docking scores in this work.