Children generations of ~500 -2000 new molecules were obtained per parent depending on the parent. The raw children results were filtered by absence of any DW toxic properties including mutagenesis, tumorigenicity, reproductive interference, irritant, and nasty functions. The DW docking-scores were ranked in negative relative units (the more negative, the higher binding).The resulting children molecules were saved as *.dwar files for complete evolutionary data storage and to *.sdf (vs3) files by File/Save Special/SD-File, selecting Docked Protonation: Structure column, Docking pose: Atom coordinates and including Cavity and Natural Ligand, for visualization opening in PyMol and using the PyMol split_states command.