To elucidate the MOF-phospholipid interactions we developed a series of experiments to determine which structural features of the MOFs interact with the phospholipids. The topology and structure of MOFs is determined by two features, the Lewis acidic metal centres and the organic bridging ligands containing multiple Lewis basic sites. Both metal centre and ligands were varied in producing a series of 11 known metal organicframeworks to investigate how these features impact MOF-GUV interactions.