The solubility of solids in organic solvents plays a huge role in various chemical systems such as organic chemistry, environmental chemistry, organo(photo)catalysis, and (petro)chemical industry. Solid-solution equilibria are, for example, used in the design of flow batteries, purification units, extraction units, and liquid phase chemical processes. Specific to the pharmaceutical industry, the solubility of active pharmaceutical ingredients (API) in a variety of organic solvents is an important property in the development of new drugs. Many curated databases (e.g. the AqSol database 1 ) are available for the aqueous solid solubility of API's as this property is of interest in the initial screening process of potential drugs. Further in the drug development chain during lab-scale synthesis, purification, crystallization, and scale-up from batch to continuous processes, information on the solubility of the API's in organic solvents other than water is required.