A wide collection of diseases are associated with aging. Figure illustrates the distribution of documents in the CAS Content Collection related to such age-associated pathologies. Among these major diseases are cancer, diabetes, and hypertension. Inflammation, cardiovascular diseases, and cognitive disorders are also highly represented (Figure ). Figure presents the annual trend in the number of documents related to the age-associated diseases. A steady growth in the number of recent publications have been documented with respect to inflammation and neurodegenerative disease including dementia and depression. Indeed, chronic lowgrade inflammation (inflammaging) has been identified as playing an increasingly important role in the rate of aging and has recently emerged as a challenging and promising new domain of aging-related research. Neurodegenerative diseases, although originating from different primary causes, all share a hallmark of neuroinflammation. 537