Spatial control in catalysis refers to the localization or separation of a catalyst from other species in reaction media. There are a myriad of reasons for which spatial control is desirable, ranging from mitigating incompatibility between reagents/catalysts, to simple heterogenization of a catalyst to be recycled, Spatial control may be realized in numerous fashions, with the bulk of this work centered around confining catalysts within compartments, and immobilizing catalysts onto supports. The last few decades have witnessed an outburst in exploring the spatial control of molecular catalysts, with several reviews outlining the intricacies and caveats of localizing catalysts. Here, we will briefly discuss the motivations and working principles for spatial control, all within the context of ultimately integrating catalysts to carry out catalytic transformations that are not trivial for purely homogeneous molecular catalysts. Two major forms of spatial control are compartmentalization and surface immobilization, which will be the main focus of this section. We will also discuss the generation of local concentration gradients as another form of spatial control that may be loosely encompassed within compartmentalization.