CBD is phyto-cannabinoid used for the treatment of epileptic seizures and in neuropathic pains . CBD solubility was below our limit of detection, and therefore practically insoluble in plain water (Table ). According to Ra calculation, the order of compatibility is pBuOzi > pPentOx > pPrOzi > pBuOx (Figure ). In general, the POzi based triblocks were found to be better solubilizer for CBD. The formulation results also revealed A-pBuOzi-A to be the best solubilizer for CBD, i.e. 3.3 g/L CBD (at 4 g/L feed), (LC ≈ 25 wt.% and LE ≈ 82%). However, with the further increase in CBD feed, a dramatic decrease in solubility was observed (i.e 0.1 g/L soluble CBD at 6 g/L feed) (Figure ). Berrocoso et al. reported the CBD loaded PEG-PLGA nanoparticles with the LC of 12 wt.% . Instead of A-pPentOx-A, as estimated by Ra calculation, the second best solubilizer was found to be A-pPrOzi-A (3 g/L soluble CBD at 4 g/L feed). The maximum achievable soluble CBD with A-pBuOx-A triblock was around 2 g/L at 8 g/L CBD feed. The A-pPentOx-A was found to be the least efficient solubilizer and gave only 1 g/L soluble CBD at 2 g/L feed. At 10 g/L CBD feed, all the four triblock formulations precipitated and, the soluble CBD level fell below 0.2 g/L. The results obtained by compatibility estimation are partially consistent with the formulation results.