The protein enrichment profiles of stereoprobe can be visualized using quadrant plots (Figure ), where the positions of proteins on the x and y axes reflect enantioselective and diastereoselective enrichment, respectively, and the size of the dot represents the degree of competitive blockade of this enrichment by the corresponding non-alkyne stereoprobe. In total, 118 proteins were quantified as being stereoselectively enriched by 3-amino stereoprobes, with 20 of these proteins being stereoselectively liganded by competitors (Figure ). The 3-amino stereoprobes stereoselectively enrich an overlapping but mostly distinct set of proteins in comparison to 3-aryl stereoprobes (Figure ), pointing to the impact of varied functional groups around the azetidine core in impacting stereoprobe binding and reactivity with distinct protein pockets. The 3-amino and 3-aryl stereoprobes also differed in their respective degrees of stereoselective liganding by competitors, in that far fewer proteins were liganded by the 3-amino stereoprobes (Figure ). This outcome is potentially consistent with the much lower proteomic reactivity of the 3-amino stereoprobes observed by gel-ABPP (Figure ).