To better reveal the rising trends in this research area, we analyzed the presence of certain key concepts in the TPDs-related research in the relevant publications. Although the cumulative number of publications having 'molecular glue' as a key concept is relatively small compared to others (Figure ), its rate of increase in the last couple of years is significantly higher (Figure ), characterizing it as a trending concept in the field of the small molecule drugs and their mode of action. Percentages are calculated with yearly publication numbers for each key concept, normalized by the total number of publications for the same concept in the same time period.