Amyloid fibril-catalyzed β-lactam hydrolysis furnishes a useful platform for degradation of antibiotic substances in water (Figure ). Notably, we demonstrated that the catalytic properties were retained even upon binding and display of the PFK fibrils upon silica beads. As such, the PFK fibril-bead constructs can be readily employed in conventional column filtering apparatuses, allowing both degradation and removal of varied water-soluble β-lactam antibiotics, and recycling of the PFK-bead system for repeated applications. Overall, the use of synthetic, easy to prepare, and environmentally benign catalytic amyloids for eliminating water-soluble β-lactam antibiotics is a promising technology addressing the major environmental and health challenge of antibiotic water contamination.