Figure (a)-(c) shows reaction optimization results, also in Appendix G. As shown in Figure , the MO-E-EQI identified Pareto front efficiently and showed a very clear trade-off between STY and E-factor. The Pareto front consisted of 20 solutions, with STY ranging from 2.66 g/(L•min) to 195.04 g/(L•min) while the E-factor ranged from 2.89 to 8.47. All the data on this Pareto front highlighted compromised solutions between STY and E-factor, which means that STY cannot be improved without worsening E-factor and vice versa.