To examine and demonstrate the dual modeling approach further, the two-step synthesis of an API was performed. benznidazole (7) is used for the treatment of Chagas disease (American trypanosomiasis) and is on the World Health Organization (WHO) list of essential medicines. The API is synthesized by alkylation of 2-nitroimidazole (4) with ethyl bromoacetate (5) to form ethyl ester 6 (Figure ), followed by TBD-catalyzed amidation with benzylamine (2a) (Figure ). Both transformations would benefit in terms of process intensification by developing a continuous flow protocol. The alkylation step also provides an opportunity to demonstrate the utility of the dual modeling approach for a different reaction type.