Figure shows a visual representation of the chemical space of NP and commercial "Fragments RO3" libraries generated with TMAP using MACCS keys. Figure large region of the space followed by ChemDiv, Life Chemicals, Enamine, LANaPDB, and CRAFT. This is in line with the quantitative diversity analysis that shows that CRAFT was the fourth most diverse "Fragments RO3" library according to MACCS keys and Morgan2 (Figure ). Figures S6, S7 and S7 show a visual representation of the chemical space of the "Fragments RO3" libraries using t-SNE, MACCS keys, Morgan2 and Morgan3 (Figure , S7, and S8 in the Supporting Information). The visualization with Morgan2 (Figure ) is very similar to the one generated with Morgan3 fingerprints (Figure ). In agreement with the TMAPs (Figure ), "Fragments RO3" of COCONUT cover a large surface of the chemical space generated with MACCS keys (Figure ), Morgan2 (Figure ), and Morgan3 (Figure ). regions than "Fragments RO3" of Maybridge, ChemDiv, Enamine, and Life Chemicals. These results mean that although the CRAFT fragments are synthetic and NP inspired, they retain similar structural features from NP-fragments, and is to be expected to overlap with the chemical space of NP-fragments like COCONUT and LANaPDB. In general, t-SNE and TMAP had similar results. Still, the advantage of TMAP in contrast with t-SNE is preserving all information about the chemical structures of fragments as possible.