It cannot be too firmly emphasised, however, that the deprotection of protected carboxyl moiety of any kind is pretty much incompatible with the above NInC hybrids, and the difficulty in finding a compatible PG for the carboxyl moiety is somewhat dependent on incompatibility of the hydrazone linker with the former's deprotection conditions such that these difficulties prompted the possibility of bypassing the carboxyl moiety protection with a PG altogether. To this end, it quickly became apparent that a masked benzaldehyde i.e. phenyl 1,3-dioxolane at C-3 of the InC species can later be deprotected together with any of the pertinent carboxyl's PG to reveal the intermediary InC 26, ready for the attack by 1 to yield the modified NInC hybrids. Starting from pbromobenzaldehyde and ethylene glycol in anhydrous THF and catalytic amount of trifluoromethanesulfonic acid, the masked acetal 24 was accomplished in excellent yields, i.e. 85-90%. Once again, 8 came in handy and was coupled to the thus obtained acetal 24 to furnish the protected InC ethyl ester 25 in good yields i.e. 65-70%, the ensuing utilisation of acid/base dichotomy rendered telescoping both acetal and ester hydrolyses in one step, so as to obtain the desired InC 26 in good yields i.e. 67-70% (Scheme 5), and as always, excellent purity, as evidenced by H NMR (ESI S50 †).