It has been reported that high-fat diet loading in wild-type mice increased MGAT2 expression in the small intestine and increased MGAT activity. Furthermore, MGAT2 knockout mice showed suppressed weight gain, insulin resistance, blood cholesterol elevation, fatty liver formation, and energy consumption even under high-fat diet loading. In general, drug absorption in the gastrointestinal tract is often rate-limited by the dissolution of the drug from the dosage form. The wettability of a drug is an important property that affects its dissolution; wettability can be quantitatively evaluated by contact angle measurements. S-309309 has poor wettability, low solubility, and low stability under acidic condition, which are challenges for formulation development. Poorwettability and low-solubility drugs may not be absorbed sufficiently in the body, resulting in an ineffective blood concentration. In addition, excessive production of related substances in the body not only impairs the stability and efficacy of the drug, but also increases the risk to patient health.