Of the top 10 selected solvents, six were found to solubilise the POC mixture at the 200 mg + 1 mL threshold and remain liquid on dissoluVon (2-methylphenol, 2-ethylphenol, 1-phenylethanol, 2-methyl-1phenyl-2-propanol, and 2-phenyl-1-propanol), one was found to solubilise the POC in a 200 mg + 1 mL sample at a slightly elevated temperature and remained liquid on cooling to room temperature (diphenyl ether -a low melVng solid), one was found to solubilise the POC at 200 mg + 1 mL but solidified on cooling (2,6-dimethylphenol), and the remaining three solvents (3-phenyl-2-propen-1-ol, 1-phenyl-3-methyl-3pentanol, 4-methyl-2,6-dimethoxyphenol) either did not fully dissolve the POC or underwent gelaVon (Table ). Overall, this led to a success rate of 70% when considering the solvents that solubilised the POC in a 200 mg + 1 mL sample. While this is slightly lower than the 84% accuracy of the HSP method when validated using previous experimental data (Table ), we believe this is a promising result, especially given we were only screening against a minimum threshold solubility over absolute solubiliVes. This promising results moVvates future exploraVon of this solubility predicVon method for porous liquid soluVons. The six solvents that formed highly soluble mixtures and remained liquid at room temperature were taken forward for size-exclusivity predicVon.