Assessment on Screening Power. Screening power refers to the ability of a SF to accurately distinguish true binders from a pool of random molecules for a given target protein. A high-performing SF is typically trained on both known ligands and randomly selected decoys to better simulate the actual positive-to-negative ratio encountered in virtual screening. In this context, the enrichment factor (EF) calculated among the top 1% of ranked ligands across all datasets is commonly used as the evaluation metric.