Once we established the signal amplification strategy and obtained their model kinetics, we then sought to incorporate this strategy into a macromolecular-crosslinked hydrogel system for naked eye SH-analyte detection. We crosslinked DMA with BAC to form cube shaped polymer hydrogels with a crosslinker concentration of 4.6 mg/mL (3.5 wt% crosslinker). The obtained gels had a water content of 98 ± 0.81 wt%, dimensions of approximately 1.3 x 1.2 x 0.5 cm (L/W/H) and had been copolymerized with methacryloxyethyl thiocarbamoyl rhodamine B (0.001 wt%) as colour indicator to enable visualization of hydrogel degradation (Figure ).