Furthermore, most power law models extend , and most mass action kinetics models extend or . Therefore, model extensions generally retain the signaling interactions of the original models. Sections 5.2 and 5.3 address the evolution of signaling molecule representations since these foundational models. Table and Supplementary Material Table itemize the temporal mathematical models that follow the power law approach. Table and Supplementary Material Table focus on those that follow the mass action kinetics approach. Table and Supplementary Material Table include those temporal models that cannot be readily categorized as following either approach. Note that spatiotemporal models are also classified by approach in the Supplementary Material Tables .