After endothelial cells interact with the LPS binding protein and soluble CD14 in plasma, LPS can directly activate the cells. Molecules such as tumor necrosis factor-α and interleukin 1 also activate endothelial cells, providing an indirect activate way for LPS-dependent endothelial cell activation . The vascular endothelium activated by lipopolysaccharides and cytokines observed during sepsis plays an essential role in organ inflammation and blood leukocyte recruitment. The increased mCD14 intensity expression on circulating monocytes may be vital to the increased inflammatory response observed in patients with the arterial disease . Activated monocytes also show an increased ability to attach to normal endothelial cells, one of the early stages of atherosclerosis . As we all know, arteriosclerosis matters in inducing hypertension. Therefore, if the endotoxin (LPS) of COVID-19 patients cannot be effectively controlled, hypertension may also be induced.