Antifungal agents are becoming less effective primarily due to the emergence of antifungal resistance among various fungal pathogens, which can be intrinsic (primary) or acquired (secondary) through mechanisms such as altered gene expression. Key resistance mechanisms include the development of efflux pumps that reduce drug concentrations at the site of action, mutations in target enzyme genes (like ERG11 for azoles) that prevent effective binding of antifungal agents, and the ability of some fungi to mutate and bypass the metabolic pathways targeted by these drugs . Given the growing challenge of antifungal resistance, there is an urgent need to explore alternative and sustainable strategies to combat fungal infections.