The coupling between chemical transport and reaction kinetics is crucial for sustaining metabolic processes and cellular function within the renal system. This ensures that the rates of enzymatic reactions are synchronized with the delivery of substrates and removal of metabolites. Disruptions in this balance can profoundly impact renal function and contribute to disease states. For instance, impaired diffusion kinetics can exacerbate oxidative stress and inflammation, accelerating renal tissue damage . In DN, elevated glucose levels accelerate non-enzymatic glycation of proteins, which affects their diffusion and subsequent biochemical interactions. This coupling underscores the importance of balanced transport and reaction mechanisms in preventing disease progression.