General Considerations: All reagents were obtained commercially unless otherwise noted. Solvents were purified by passage under 10 psi N2 through activated alumina columns. Infrared (IR) spectra were recorded on a Thermo Scientific™ Nicolet™ iS™5 FT-IR Spectrometer; data are reported in frequency of absorption (cm -1 ). H NMR spectra were recorded at 400, 500, or 600 MHz. Data are recorded as: chemical shift in ppm referenced internally using residual solvent peaks, multiplicity (s = singlet, d = doublet, t = triplet, q = quartet, m = multiplet or overlap of nonequivalent resonances), integration, coupling constant (Hz). C NMR spectra were recorded at 101 MHz or at 126 MHz. Exact mass spectra were recorded using an electrospray ion source (ESI) either in positive mode or negative mode and with a time-of-flight (TOF) analyzer on a Waters LCT PremierTM mass spectrometer and are given in m/z. TLC was performed on pre-coated glass plates (Merck) and visualized either with a UV lamp (254 nm) or by dipping into a solution of KMnO4-K2CO3 in water followed by heating. Flash chromatography was performed on silica gel (230-A 250 mL round-bottom flask was charged with a stir bar, 1 (10 g, 84.7 mmol, 1 equiv.), and MeOH (100 mL). Subsequently, morpholine (8.0 mL, 8.08 g, 92.8 mmol, 1.1 equiv.) was added at room temperature, and the reaction mixture was stirred for 14 hours. Following this time, the reaction was concentrated under reduced pressure using toluene as an azeotrope (50 mL x 3) to remove excess morpholine. Then, CH2Cl2 (100 mL) and acetone (25 mL) were added to the crude product, and the mixture was cooled to 0 °C using an ice-water bath. 2,2-dimethoxypropane (20.2 mL, 17.2 g, 165 mmol, 2 equiv.) and camphorsulfonic acid (6.6 g, 28 mmol, 0.33 equiv.) were added sequentially. The reaction mixture was warmed to room temperature over a period of 3 hours. Following this time, the reaction was quenched by addition of Et3N (8.0 mL) and concentrated under reduced pressure. The resulting residue was purified using a gradient of 0 to 50% EtOAc/hexanes on silica gel to yield 2 (white solid, 18.2 g, 74.2 mmol, 88% yield).