. With the assumption that model structures and ideal structures represent two different minima for any ligand, RMSD values of the conformers produced by DeepConf, Auto3D or RDKit against bioactive conformations are a good indicator to show the success of the conformer generation algorithms. However, this is only one part of the problem and the energy difference between model and ideal structure also needs to be distinguished by the algorithm. For this reason, we have also analyzed the results by comparing relative energies among conformers (Table ).