Metal-organic frameworks (MOFs) as high surface area materials are arguably one of the most ideal supports with chemical tunability, insolubility, recyclability, and so on. Besides, supported noble metal heterogeneous MOFs have formed a large number of effective catalysts used in practical applications. Recently, progresses in the applications of Pd-supported MOFs to propel catalyze organic transformations have been well documented. In addition, several MOFs loaded Pd have been developed to catalyze the reaction of vanillin HDO reaction. For instance, Samy El-Shall's group prepared palladium nanoparticles encapsulated in NH2-UiO-66 MOF and used the Pd@NH2-UiO-66 catalyst in the hydrodeoxygenation of vanillin at 90 C under 0.5 MPa H2 pressure. Zhang and co-workers fabricated Pd NPs supported on MOFs by an incipient-wetness impregnation method.