Underpinning this performance, physico-chemical properties of brushes that regulate biomacromolecular interactions and adsorption to the surface of corresponding coatings and nanomaterials appear key. Protein coronas have long been established to modulate cellular internalisation and the stability of colloidal suspensions, in turn impacting the transfection of gene delivery vectors . Understanding parameters regulating macromolecular interactions in complex solutions is critical to the control of protein resistance properties and the long term performance of coatings . Similarly, the adsorption of extra-cellular matrix proteins at the surface of biomaterials modulates a broad range of cell phenotypes, from cell adhesion and spreading to cell expansion and the retention of stem cell phenotype and pluripotency .