The results indicate a significant dependence of this chemistry on the sustained power applied during the reaction, with higher wattage or longer residence time conditions resulting in noticeably lower yields. Remarkably, one reaction condition exhibited optimal performance at the lowest "turned on" power output, specifically molecule 9 at 2 W optical output. This outcome, which defies conventional expert intuition, further highlights the challenging nature of prediction in this context. Additionally, during the optimization of molecule 9, various CF3 sources were screened, including trifluoromethyl thianthrenium triflate and Umemoto's reagent, serving as a test case to evaluate discrete variables. Notably, the algorithm determined that Umemoto's reagent was the optimal choice for this transformation.