During the treatment process, mice body weight and tumor volume in different treatment groups were measured and recorded every other day. After treatment, tumor photos of different groups were shown in Fig. . Additionally, mice were imaged at 0, 7 and 14 days to monitor treatment effect (Fig. ). The tumor in EH@Ag2S +US group were obviously smaller than in other treatment groups, and the tumor growth was significantly inhibited. The EH@Ag2S +US group showed the most significant antitumor treatment effect, and tumor growth inhibition (TGI) index reached 98.4% compared with the PBS group as the grave and higher than the other groups (Fig. ).