Laccase immobilization on activated BNNS-Arg (BNNS-Arg@Lac). One mL purified natural laccase (nlaccase) (purified method in supporting information) was mixed with 100 mg EDC/NHS-activated BNNS-Arg in 10 mL 0.1 M Na-PO4 buffer (pH 3). The solution was stirred overnight at 30 °C, collected, and then vacuum-filtered. The solid sample was washed with DI water for non-immobilized nlaccase and dried at room temperature in the fume hood. After that, the generated BNNS-Arg@Lac activity was analyzed by 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) assay (see supporting information). The process of synthesizing BNNS-Arg@Lac was shown in Figure .