The outcome of the simple temporal validation experiments presented in this section highlight the need to periodical retraining of the models such as those described herein, to ensure their usefulness for medicinal chemistry projects. None of the previously published studies for context prediction performed a temporal analysis, which indicates that they may be prone to similar deficiencies. While we highlight the limitations of only relying on historical data here, it also is important to stress that historical data might still be chemically relevant, and an old context could be just as effective as a new one. Indeed, most ligands can yield high product concentrations in the cases where the amine and halide are highly suitable for this type of reaction. Thus, it is not always needed to employ the more recent and supposedly more performant contexts for all planned synthesis, although as it is clear from Figure , that chemists tend to use more recent contexts.