We have presented here an overview of the most important aspects of the PSI after 20 years of efforts, including its current operation, the current status of existing standards, ongoing work for standards in progress, and synergies between the PSI and community groups. These activities demonstrate the commitment of the PSI in accelerating the pace of biomedical research by facilitating the dissemination and reuse of data and interoperability of software. There are many ongoing standards in development, and it is perhaps worth reiterating that greater community participation is always welcome, since such greater participation leads to better standards. As the PSI completes these standards, new needs will emerge as the field advances. Already there is growing interest in standardization around the rapidly emerging high-throughput affinity-based protein quantification platforms, and some initial discussions have taken place at PSI workshops, although a clear plan has not yet emerged.