We computed several metrics to assess the success of a method and compare methods by accuracy and correlation statistics with experiment. However, the usefulness and interpretability of statistical performance measurements obtained depend on experimental dynamic range, experimental error, and number of data points. Accurate predictive models become more difficult to build or assess when experimental dynamic range is small or if there are large experimental uncertainties. In SAMPL9 host-guest challenge, bCD dataset has a low dynamic range, thus we obtain a realistic or upper-limit of model performance by quantifying the experimental uncertainty using the equation: