appears highly sensitive to the external temperatures at values of -8°C and -10°C. The reason for this lies in the temperature-dependency of the nucleation rate. Nucleation events become rarer with increasing vial temperature, which explains the exponentially increasing nucleation times in Figure (a). Since the temperature-dependency of nucleation is highly non-linear, nearly no nucleation events are observed above a certain temperature, while faster rates are observed for lower storage temperatures. Thus, for low storage temperatures, most nucleation events take place early in the process during the initial cooling towards the storage temperature. For -10°C and -8°C, however, most nucleation events occur after vials have reached the vicinity of the storage temperature, thus explaining why the distribution in 13 (b) narrows down in these cases. Such behavior may be inferred from Figure ) as well, that clearly shows that for a storage temperature of -10°C some vials nucleate after reaching the storage temperature, while all vials nucleate during the initial cooling in the case of -20°C.