Nowadays, there is a growing interest in the development of a universal vaccine for the influenza virus which should be effective against multiple strains of influenza and novel pandemic viruses in the future. Despite several benefits of these UIVs, there might be some unintended consequences on the population. Recently, a study utilized mathematical modeling techniques to find out such consequences. Results indicated that a potential universal immunization program might increase the vulnerability of the population to escape the vaccine variants which could permit a larger pandemic in the population. To reduce these potential risks, the UIV vaccines must be deployed optimally i.e. it should be a mixture of both conventional as well as multiple antigen targets (universal targets). Moreover, it should also be able to cover a sufficient population .