To give an idea of the data sparsity across variants in the different subsets, variant coverage was calculated and reported as defined in the section Common subset design. To summarize the bioactivity distribution information, the mean and standard deviation pChEMBL value for each variant was calculated. Moreover, the difference in mean pChEMBL value with respect to the WT was calculated for each variant by subtracting the variant's mean pChEMBL value from the WT's mean pChEMBL value.