IPR012588 is the Exosome-associated factor Rrp6 N-terminal. Exosomes are nanocompartments that are involved in the degradation or processing of RNA, such as mRNA, rRNA, snRNA, and snoRNA. Exosomes are ubiquitous in archaea and eukaryotes, where they engage in interactions with bacteria and organelles.PNPase (polynucleotide phosphorylase) is a barrel-like structure that is composed of a hexameric ring of PH domains that functions as a degradation compartment and a cap containing an S1 domain/KH domain that binds RNA substrates (and occasionally accessory proteins) to regulate and restrict access to the degradation compartment. Exosomes come in two types in eukaryotes: cytoplasmic exosomes and nuclear exosomes. Cytoplasmic exosomes break down mRNA using 3'-5' exoribonuclease, while nuclear exosomes break down pre-mRNA (like nonsense transcripts) and rRNA, snRNA, and snoRNA.