Another recent study discussed the development of a novel impedimetric immunosensor design for detecting dengue virus (DENV) IgG antibodies using plant-derived antigenic glycoprotein. The electrochemical immunosensor platform was constructed using a screen-printed carbon electrode (SPCE) modified with a graphene/titanium dioxide (G/TiO2) nanocomposite to enhance the electrode's electrochemical performance and specific surface area. The researchers used a plant-derived dengue envelope domain III (EDIII) protein as the antigenic probe protein in their immunosensing strategy. The immunosensor demonstrated high sensitivity towards DENV IgG in a wide linear working range (62.5-2000 ng/mL) and a limit of detection of 2.81 ng/mL under optimised sensing conditions. The immunosensor showed high specificity for distinguishing DENV IgG from antibodies of other infectious diseases, including the closely related Zika virus (ZIKV). To verify the reliability of the immunosensor in serological diagnosis, the team challenged it against serum samples and compared the results to conventional enzyme-linked immunosorbent assay (ELISA). Based on its remarkable performance throughout the study, the team proposes the devised immunosensor as a reliable and practical diagnostic tool for serological detection of dengue in realistic applications. In summary, the development of an impedimetric immunosensor based on the G/TiO2 nanocomposite modified electrode platform for detecting DENV IgG was reported. The researchers optimized various sensing parameters to improve sensitivity and selectivity, using a plantbased cEDIII peptide as a probe. The immunosensor demonstrated high sensitivity towards DENV 1-4 IgG detection, with a limit of detection of 2.81 ng/mL within a linear working range of 62.5 ng/mL to 2 μg/mL. Additionally, the immunosensor exhibited high specificity for discriminating DENV IgG against antibodies of other infectious diseases, including the similarly structured ZIKV. The immunosensor was stable and had an acceptable shelf-life, with only a minute signal decrease over 15 days. The researchers also investigated the analytical performance of the immunosensor in detecting dengue antibodies in serum samples with the aid of an optimised blocking protocol. The immunosensor produced distinctive readings to identify DENV IgG-positive samples in a wide working range from a dilution factor of 1:500 up until 1:32,000, and the results were comparable to readings from conventional ELISA assays. The key elements of the immunosensor offer attractive merits on their own, including the large specific area and excellent catalytic properties of G/TiO2 nanocomposites, the scalability and low cross-reactivity of plant-based cEDIII, and the rapid response, miniature size, and low costs of electrochemical biosensors. Combining all these qualities, a promising analytical tool with good sensitivity and specificity could be developed for dengue diagnosis, which holds great potential to be further developed into a point-of-care diagnostic assay for clinical use.