Based upon our previous research into chlorine-fluorine exchange in sulfur chlorides, we decided to leverage flow technology for these transformations. We anticipated that a packed bed reactor filled with an alkali fluoride would be well-suited for generating the targeted trifluoromethyl-heteroatom anions (Figure , reactor design). This design increases the efficiency of the multiple fluoride additions due to the increased surface area and improved mixing between the organic intermediates and the insoluble fluoride salt. Importantly, this approach offers enhanced safety as all formed intermediates are contained within the microfluidic system. Additionally, by integrating a reaction module downstream of the CF3X anion generator, we enable its seamless incorporation into electrophiles, thereby providing a divergent and streamlined platform for the derivatization of molecules bearing heteroatom-CF3 motifs.