Here ∆G 0 bind is the binding free energy of the guest molecule in complex with native β-CD and α is the slope of such a model in units of kcal/mol/DS. Fitting eq 4 separately for up and down to the free energies of binding presented in Figure gives r 2 values between 0.70 and 0.93 with parameters for the linear models presented in Table in the supporting information. In Figure the slopes from the linear models as a function of the log(P ) values of the molecules taken from Table is shown. The slopes for molecules in the down orientation and down orientation, respectively. From Figure there appears to be a linear connection between the presented slopes and log(P ). Linear models of the slopes as a function of log(P ) has r 2 values of 0.97 and 0.96 for up and down, respectively, and are shown in Table in the supporting information. These models are thus able to predict the slopes of Figure based only on the molecules log(P ) value.