Further, we compare our results with two relevant works in the field. A similar concept of strategic molecules for the design of biomedical applications are so-called privileged scaffolds. These molecular frameworks are formed of geometries, which are suitable to be coupled with different side chains. We suggest that highly ranked privileged scaffolds, due to their Shannon entropy, should be a subset of strategic molecules, as these might represent molecules at important junctions in the network. With regard to the highest ranked five scaffolds (see Figure ), the isolation forest algorithm identifies four of these and a related structure to the fifth one. Quinoline, diphenylmethane, diphenylether, and