The changes in these bond lengths and torsions are largely responsible for the more favorable ∆𝑈 𝑏𝑜𝑛𝑑𝑒𝑑 ‡ seen in BsCM. Interestingly, one finds that the average value of ∆𝑈 𝑛𝑜𝑛𝑏𝑜𝑛𝑑 ‡ is actually less favorable in the promiscuous PchB enzyme than in both water and BsCM. This is likely due to poorer substrate preorganization, as the chorismate mutase reaction is not the primary function of this enzyme.