To thoroughly investigate the difference in the limit of quantitation on a larger scale, a broad variety of chemicals were included in the study. Comparisons between HRMS and QQQ measurements have been reported in the literature, but these targeted only a limited range of chemicals, e.g., flame retardants (polybrominated diphenyl ethers, PBDE) , illicit drugs , and small molecules used in the clinic ). In our study, the LOQ of the QQQ was on average 6 and 9 times lower for urine and solvent, respectively, than HRMS. Most previous studies reported similar, or slightly lower, LOQs for QQQs . Only observed significantly lower LODs (10-100 fold) with QQQ for PBDEs with a maximum of four bromides in fish. The equipment used in all these studies differed from our selected configuration.