Since, multiple reports have demonstrated the ability of TSEMO to optimize multiobjective optimizations for the synthesis of organic molecules (see examples in Table , entries 3-5, 6-8). A particular noteworthy development is the application of TSEMO for the optimization of synthetic routes composed of two and more successive reaction steps or telescoped reactions . Sagmeister et al. reported the optimization of a two-step telescoped synthesis of the active pharmaceutical ingredient edaravone (Table , entry 9). In this study, a self-optimizing flow reactor was used to run the optimization of seven continuous variables including three variables for the first step and four variables for the second step reaction. The optimization had the objective of maximizing the yield of the imine intermediate ( ) obtained after the first reaction, the STY of 52 and minimizing the overall used equivalents of the reagents. After 85 iterations, a maximum yield of 95% for the synthesis of 51, and a maximum STY of 5.42 kg/h for the synthesis of edaravone were achieved. Setting an objective that limited the quantities of reagents led to the discovery of unexpected reaction conditions where the sub-stoichiometric amount of triethyl amine was sufficient to promote the second reaction step decreasing the waste produced during synthesis.