Fig. shows the thermodynamics of DS -binding to the AWI. In our discussion of the E DS -,W (z) decompositions (Fig. ), we emphasized that the DS -head group remains relatively well-water-solvated as a result of interfacial adsorption to the AWI (also see the SI), and so the thermodynamics mostly reflects the effects of desolvating the DS -tail group (see our discussion of DS 0 adsorption below). Therefore, based on the analysis presented in 55, in the process of DS -adsorption to the AWI, the energetic component mostly quantifies the change in the DS --water LJ interactions as a result of desolvation, while the entropic component mostly quantifies the effect of removing the DS -tail group cavity from the bulk water. In this case, the entropic component overpowers the energetic penalty, and the net free energy change is attractive, thus favoring surface adsorption.