In order to further validate the best distance scoring model trained with SDF fingerprints, we have performed the systematic analysis of retrosynthesis predictions for 50 random molecules from the test set. In accordance with the high top-1 accuracy of the SDF model (0.60), for 30 out of 50 molecules, the top-scored route was observable from literature experimental studies. Out of the other 20 molecules, in the case of 15 the top-1 scored route is deemed to be a good, often shorter, alternative. For example, the suggested plausible 2-step synthesis of a thiazole derivative is deemed superior to the 4-step experimental observable from the literature (molecule 23, routes 1 and 29, Figure and). When combined with the 30 correctly predicted experimentally observable routes, this results in 45 of 50 synthetically feasible routes, or 90% which is better than the current state-of-the-art SOA performance . For the other 4 out of 20 molecules where the model failed to correctly predict the route extracted from the literature the top-scored synthesis route appeared to have a plausible disconnection strategy but required certain modifications of the individual steps to make the route efficient. Thus, the predicted route towards the bis-amide shown in Figure (molecule 18, route 2) is plausible but a one-step shorter synthesis route from a commercially available des-chloro analogue is more efficient and similar to what is reported in the literature . For one out of 50 molecules, the model failed to either predict the experimentally reported route or suggest a good or plausible alternative as the top-ranked prediction (Figure , molecule 8, route 5). Here, the synthesis strategy has to be significantly changed, and both steps of the current route are likely to fail. Doing further expert chemistry analysis of the second-best suggestions, we have formulated the following route approximate route feasibility scale based on the predicted value of the distance.