All the isolated compounds were devoid of any significant activities both on the antimicrobial (twelve strains) and cytotoxicity assays (two cell lines). Similar compounds have been reported to exhibit low to no activities in equivalent studies. Supported by the reported neurite outgrowth activity of other drimane sesquiterpenoids isolated from Cyathus africanus and C. stercoreus, we decided to assess drimane-type sesquiterpenoid compounds (1-6) for neurite outgrowth assay in rat pheochromocytoma cells (PC-12), a wellestablished model system. To measure the nerve growth factor (NGF) enhancing activity of compounds (1-6), PC-12 cells were treated with 5 ng/mL NGF in the presence or absence of the compound at a concentration of 5 µg/mL, respectively, and the mean neurite length was measured after 48 h of treatment (Figure ). Compounds 7 and 8 were not tested due to inadequate isolated amounts.