To mitigate these challenges, a subset of PubChem called PubChemLite was developed specifically to streamline NTS identification and interpretation . PubChemLite has been integrated into existing HR-MS workflows, such as patRoon and MetFrag . Although PubChemLite is familiar to many researchers already, the original 2021 article was primarily technical. This article explains PubChemLite for an environmental/exposomics audience and details extensions since the original publication, including the development of an open experimental CCS pipeline in PubChem, integration of predicted CCS values in PubChemLite to support IMS, and finally a new web interface ().