The last case study undergoes a more complex reaction mechanism (Figure ). An intermediate step in the Waferin synthesis route contains an extended electron rearrangement as shown in Figure , referred to as enolate chemistry. The result of this is a potentially endergonic reaction profile as the enolate cascade disrupts the conjugated system present in the reactants, leading to a loss of aromaticity. Hence, it is intriguing to determine whether the model can predict the precursors at all. Furthermore, it is of interest if the model can provide the electron movement path as a reason for its prediction. ). However, it fails to highlight the electron movement path (subplot b compared to Figure ). It is therefore likely that this disconnection was chosen due to a lack of other alternatives.