Hansen solubility parameters (HSPs) provide a method to quanVtaVvely assess the likelihood one molecular compound will dissolve another and have seen previous success across a variety of applicaVons, ranging from pharmaceuVcals, to polymers, and materials chemistry. For example, HSPs have been used to idenVfy solvents that opVmise the dispersion of nanomaterials such as graphene, to select green extracVon solvents for bioacVve compounds, to predict the dispersion of nanoparVcles in polymeric films, to predict miscible mixtures for cocrystal formaVon of a drug and conformer, and to correlate the solubility parameters that govern self-assembly in molecular gels. Typically, however, HSPs are used to raVonalise and predict the solubility behaviour of small molecules, polymers, and parVcles, rather than discrete large molecules such as candidate POCs. In addiVon, the requirement for solvent size-exclusivity to form type II PLs may affect the overall solubility and present a unique challenge. Therefore, here, we wanted to explore the applicability of HSPs to PL solubility predicVon.