Inuence of parameter HEIGHT Fig. shows the inuence of parameter HEIGHT on the key reactions for cyclic C 6 O 2 H- 2. As written above, template 2 will mainly yield epoxides for the cyclohexane case when working properly. We therefore check for how often 1,3-epoxycyclohexane is produced when varying parameter HEIGHT. For HEIGHT larger or equal to 3.2 kcal mol -1 , the desired product is obtained in more than 40 % of the samples with this reaction event, cf. Fig. . CPU time was saved by nearly 50 % compared to the case of 0.1 kcal mol -1 . A further increase in HEIGHT continued to lower computational costs without diminishing the recognition rate. Through a comparison regarding the average CPU time, it was shown that the bondbreaking process, cf. template 4 in Fig. , evolves an order of magnitude faster than the bond formation process. The latter one usually spends more time trapped in one well until sucient energies have been accumulated. To further study the increased proportion of the desirable product 3-butanal, we extend the bias potential range by 5 kcal mol -1 and 10 kcal mol -1 in our automatically generated CVs, facilitated by the extremely low CPU time needed, cf.