While capsaicin has been a TRPV1 agonist that has been more thoroughly studied, resiniferatoxin has proven to be a much more potent TRPV1 agonist, being over 1000 times more effective in neuropathic pain treatment . The long-lasting desensitization of TRPV1 with resiniferatoxin allows for a long-lasting analgesic effect, and with studies proving TRPV1's association with inflammation as well, resiniferatoxin might very well be able to reduce inflammation in its activation of TRPV1, as well.