Magnetic Hyperthermia-Induced In Situ Drug Amorphization in Tablets. Tablets were prepared based on the formulation design space (Table ) constructed using DoE to investigate factors for magnetic hyperthermia-induced drug amorphization. Table summarizes the tablet compositions, process conditions and the observed degree of amorphization. The tablet containing 30 wt% celecoxib and 20 wt% Mn0.5Fe2.5O4 exposed to AMF for 15 min (tablet 26, Table ) showed maximum amorphous content induced by in situ amorphization, and is thus presented here in detail (Figure ). Figure shows the temperature profile of this tablet and the thermal images recorded with IR camera at four time points are shown in Figure . The tablet surface temperature rapidly increased from room temperature to 154 °C within the first three minutes of AMF exposure. The tablet temperature further increased to a maximum (Tmax) of 165 °C after 6 minutes and was maintained there for the remaining time of AMF exposure. As the SPIONs are homogenously distributed in the matrix, hyperthermia results in uniform heating of the entire tablet, as shown here by the mono-colored thermal images (Figure ). The uniform heating ensures complete drug amorphization in the tablets. This is a clear advantage of magnetic hyperthermia-induced amorphization over the previously reported laser-radiation approach. The latter can only be applied to thin tablets due to the limited penetration depth of the laser. Some of the tablets showed deformation after AMF exposure due to water evaporation and increased polymer mobility above the Tg of PVP (here Tg = 80 -85 °C). A significant decrease in viscosity of the polymer has been observed at approximately 15-25 °C above the Tg of the polymer, enabling the drug dissolution and amorphization process. Here, the onset temperature for drug amorphization was determined by differential scanning calorimetry (DSC) and was found to be 103.6, 117.7, and 117.6 °C for a drug load of 30, 40, and 50 wt% respectively (Tg + (15-25) °C depending on wt% of celecoxib). At temperatures > Tg, the polymer viscosity decreases leading to a drastic increase of molecular mobility in the network. Thus, the drug dissolves easily into the polymer and in situ amorphization is initiated. The AMF-exposed tablet in Figure significantly exceeded the onset temperature required for amorphization of celecoxib and was maintained above that temperature for an adequate time, thus ensuring an efficient in situ amorphization by hyperthermia.