Compound QC (Quality Control) Analysis. Purification of the compounds was carried out either using pre-packed silica gel cartridges (Biotage or ISCO) or reverse-phase HPLC (Highperformance liquid chromatography) with C18 columns, >95% purity for all the active compounds tested in the biological assay has been confirmed by analytical HPLC. 1 H NMR (proton nuclear magnetic resonance) spectra were recorded in acetonitrile-d3 or methanol-d4, on Bruker NMR spectrometer with 400 or 500 MHz 1H Larmor frequency. NMR chemical shifts (δ) were quoted in parts per million (ppm) and are reported relative to residual nondeuterated solvent signals. Coupling constants are reported in Hertz (Hz). Splitting patterns are indicated as follows: br, broad; s, singlet; d, doublet; t, triplet; q, quartet; dd, doublet of doublets, m, multiples.