In this work we have shown how styrene-maleic acid copolymers located in the intra-organelle space function as stabilizers of the fusion pore. We have conducted µs-length coarse-grained unbiased molecular dynamics to measure the life-time of the fusion pore in the presence of different amounts of SMACs, located in both intra and extra-organelle spaces, exclusively and simultaneously. We have shown that the amount of intra-organelle SMAC:lipid contacts that spontaneously form are the key in the stabilization mechanism, being extra-organelle ones inconsequential or even antagonistic to this end. As stabilized pores are less likely to proceed to the expansion regime , an event facing a major energy barrier , we propose SMACs as an artificial tool to stabilize the fusion pore by tuning its dynamics, to control exocytosis and to regulate vesicle cargo discharge.