shows no significant evidence for drift of the free energy estimate, but we take it to mean that there is no drift of the free energy estimate ("The Fallacy of the Transposed Conditional"). Furthermore, like all equilibration detection methods we are aware of, this method requires that initial simulations have been run on a timescale comparable to that of the initial transient; very slow equilibration will not be apparent from very short simulations. Our workflow likely depends on the correlation between slow initial relaxation and large inter-run uncertainty, which means that sufficient sampling time is allocated to the bound vanish legs to allow the initial transients to be detected and removed. In addition, the method is sensitive to parameters such as the number of t-tests performed and the number of replicate runs.