LinChemIn is a software package written in Python 3. The source code is available to the scientific community at and is open to external contributions through standard git workflows. LinChemIn depends on a handful of common and reliable third-party python modules. For instance, RDKit is the chemoinformatics workhorse of this application, while graph arithmetic leans mostly on NetworkX . We actively manage the package dependency map, aiming at a low coupling with applications or modules that are not compatible crossplatform (e.g., GraphTools) or that bring potentially conflicting second-tier library dependencies (e.g., RXNmapper). We rely on dedicated REST APIs (Application Program Interfaces) or format-controlled I/O to deal with such cases.