The practical implementation of this model reaction definition has been performed using the atom and bond types developed in the Topologically Automated Force-Field Interactions (TAFFI) methodology,, which was initially designed for force-field development but has also been successfully applied in property prediction models and is a maintained code-base for molecular adjacency operations within our group. A brief introduction of the central features of the TAFFI atom types and the modifications on atom and bond types, as well as the definition of the reaction type are present in the SI (Section 1). For a more detailed description of TAFFI, we direct readers to the original publication.