Notably, such a small difference was also documented for the other two parameters, radius of gyration Rg and end-to-end distance Re, in the case of PLGA16 and PLGA64 samples, regardless of the mapping type (Table ). Multiple factors could contribute to explain this minor discrepancy. According to the 4:1 MARTINI mapping scheme (v2.2), 4 heavy atoms in the atomistic model are represented by one bead in the coarse-grained model. In our model, a standard size CG bead maps instead the 5 heavy atoms of the group XL. Additionally, the standard size MARTINI bead has a larger radius than the chemical group XG that it accommodates. This in turn causes a slight interpenetration of neighboring CG beads when their bond length is assigned to map the atomistic distance between XG and XL COMs, promoting an artificial increased beads affinity and a partial collapse of the chain. Finally, the methyl group in the LA monomer likely disfavors chain packing as the experimental increased density of PLGA with the glycolic content suggest , but this effect is expected to smooth when the system is modeled at CG resolution. As an alternative, a smaller size bead (S type) was employed to map the XG monomer. When PLGA chains were built using a dimeric SNa-Na unit, the resulting density values for pure PLGA16 and PLGA64 coarse-grained samples were approximately equal to ≈1.1, which is 0.1 g cm -3 lower than the estimated values from atomistic simulations of similar systems configurations (see Table ). Next, the solubility of PLGA in selected solvents was assessed. According to the Flory theory, as detailed in the Methods section, the size of a polymer chain in a dilute solution depends on the solvent: the polymer swells if the polymer-solvent interactions are dominating (good solvent condition); while the polymer collapses if the polymer-polymer interactions are dominating (poor solvent condition).