The notations N(T)/L(T)/HF, T(T)/L(T)/HF, and T(T)/N(T)/HF are adopted from Ref. 26. Moreover, in the Supporting Information, the results for pair-selected multi-level DLPNO-CCSD(T 0 ) are shown for additional threshold combinations. Naturally, decreasing the prescreening thresholds from 1 • 10 -5 to 5 • 10 -6 for the threshold combination in Tab. 2 reduces the MAD and SD with an increase in computational time. The performance of this threshold combination is similar to the pair-selected multi-level DLPNO-CCSD(T 0 ) approach as proposed in previous work combining TIGHTPNO and NORMALPNO settings, denoted as T(T)/N(T)/HF, with a selection threshold of 1 • 10 -3 (Fig. ). In contrast, the threshold combination in Tab. 2 performs similarly to the approach from previous work using a combination of TIGHTPNO and LOOSEPNO settings