Dierent templates have a focus on dierent reaction classes as can bee seen from Fig. . Template 2 (cobf ) derived from the cyclohexane system exhibits a good performance in discovering epoxides and OH-transfer reactions. Template 3 can be regarded as the most all-around and robust template owing to its complex composition. Template 4 (ccbb w/o switching function) and template 5 (ccbb) derived from cyclohexane and n-butane system, respectively, exert their eects on accelerating C C bond ssion. Both are implemented to improve the diversity of this kind of reactions in paran and naphthene systems. Template 6 (ccbf ) was also obtained from the n-butane system in order to promote the formation of methyl-cyclopropane and cyclobutane. Its capability in discovering the same reaction class in cyclohexane system has been successfully proven by the template tests.