Compounds 1, 2, and 5 show ligand interactions with 5U09. The interactions between the ligand and protein are H-bonding and π-cation. Compound 2 has the lowest binding energy at -10.63 kcal/mol. However, compound 5 has the most stable ligand-protein complex with relative bindingfree energies of -87.92 kcal/mol and -75.94 kcal/mol. All five compounds show ligand interactions with 6KQI. The interactions between the ligand and protein are H-bonding and π-stacking. Compound 4 has the lowest binding energy at -9.75 kcal/mol. Compound 5 is the most stable ligand-protein complex with relative binding-free energies of -69.21 kcal/mol and -50.64 kcal/mol. All five compounds show ligand interactions with 7V3Z. The interactions between the ligand and protein are H-bonding and π-stacking. Compound 1 has the lowest binding energy at -10.66 kcal/mol. Compound 2 is the most stable ligand-protein complex with relative binding-free energies of -71.00 kcal/mol and -51.80 kcal/mol. All five compounds show ligand interactions with 5ZTY. The interactions between the ligand and protein are H-bonding and π-stacking. Compound 4 has the lowest binding energy at -10.44 kcal/mol. Compound 4 is also the most stable ligand-protein complex with relative binding-free energies of -77.48 kcal/mol and -63.08 kcal/mol.