The thermodynamic approach was shown to be particularly successful for our hydro- V m can serve as a proxy for crystal lattice energy. We also explain why one featurization approach may be better than the other in different circumstances (in this case, the class of molecules being studied) which can provide guidance on what types of models to use for a specific use case. Future work could include 1) more rigorous tuning of the hyperparameters in the random forest models, and 2) identifying more readily available features that describe macroscopic properties and incorporating them in a melting point prediction model and 3) applying the mordred-calculated featurization and thermodynamic featurization to the same subset of molecules to conduct a rigorous examination of the differences between the models.