and the flow rate of the reaction solution. As the reaction yield by organic microdroplet chemistry may be reduced under the standard reaction conditions by using the high flux strategy, the temperature and the sulfuric acid equivalent may be enhanced to improve the yield of vicinal diamine 2a in the scaled-up. As shown in Table , when the substrate 1a was ten-fold concentrated (0.05 mol L -1 ), the amount of the vicinal diamine 2a was enhanced by nearly ten times although the yield of this reaction was not good as the microdroplet reaction under the standard conditions (0.005 mol L -1 1a). When the microdroplet reaction was carried out at a raised temperature (50 °C), the amount of the vicinal diamine 2a was further enhanced by upscaling the flow rate of reaction solution to 300 μL•min -1 (Table , Entries 2-6). For example, a product 2a amount of approximately 3.0 mg min -1 (177 milligrams per hour) can be obtained by using 0.05 mol L -1 imidazoline derivative 1a at 300 μL min -1 (Table , Entry 6). When the concentration was continued to increase to 0.1 mol L -1 , the yield was good at low flow rates (15 μL•min -1 ) but was sharply decreased at high flow rates (Table , Entries 7-9). It indicated that the high flux strategy was incapable to further scale up the microdroplet reaction (at most 177 mg h -1 ). By utilizing the array sprayers and solvent recycling strategies, it is anticipated to readily enlarge the product amount to several grams per hour.