Transcription initiation factor TFIID subunit 12 (IPR003228) is the transcription initiation factor. TFIID is one of several general transcription factors (GTFs) that are involved in the precise initiation of RNA polymerase II transcription in eukaryotes. The other GTFs are TFIIA, TFIIB, TFIIE, TFIIF, and TFIIH. TFIID significantly influences the recognition of promoter DNA and the assembly of the pre-initiation complex. TATA binding protein (TBP) and at least 13 TBP-associated factors (TAFs), individually or collectively involved in activator-dependent transcription, compose the human transcription initiation factor TFIID.