Both cases demonstrate the feasibility of enantioconvergent decarboxylative C(sp )-C(sp 3 ) cross-coupling using reactive primary radical species. The Fu's group realized the asymmetric decarboxylative Negishi cross-coupling reaction of α-amino acid-derived NHPI esters (Figure ). Subsequently, the Baran's group further demonstrated asymmetric decarboxylative Negishi-type alkylation of α-oxy carboxylic acids (Figure ). These two methodologies showcase the potent combination of decarboxylation of α-heteroatom-substituted carboxylic acids with organometallic reagents in an enantioselective pathway.