The modified DFTB3 Hamiltonian significantly improved the description of the hydride transfer reaction in Ccr, reproducing the reference DFT activation barrier within 0.1 kcal/mol. Our detailed analysis revealed that while the primary effect is on the transition state region, systems forming charged intermediates like an enolate still present challenges due to inherent limitations in DFTB3's electronic structure description. Nevertheless, for DHFR, which does not involve enolate intermediates, our approach provided excellent agreement throughout the entire reaction profile without further adjustments.