Figure shows the TMAP of LANAPDB generated from the MACCS keys (166-bit) fingerprint, and their comparison with the FDA-approved small-molecule drugs. The interactive version of the TMAP is freely available at (to open the interactive map, download the file and open it in a web explorer, zoom in option available with the mouse scroll). In the interactive version of Figure , it can be appreciated that the TMAP accomplished effectively the clustering of structurally similar compounds in "branches." Figure shows that all the countries and the approved drugs overlap with the Brazilian NPs. Therefore, Brazil is the country with the highest structural diversity of NPs according to the TMAP. Moreover, Figure shows that the compounds for each one of the seven Latin American countries are in general not focused on a certain region of the chemical space. Instead, they are distributed across the chemical space and, in many cases, clustered, forming branches of structurally similar compounds. Besides, all the Latin American countries partially overlap with the approved drugs in specific regions. Figure depicts the comparison of LANaPDB with COCONUT and the approved drugs.