5 M ODN6UV was incubated with HCT116 cell lysate (the final protein concentration is 100 g/mL) in buffer A at 37 °C for various time intervals. For the control group, 5 M ODN6UV was incubated with HCT116 cell lysate and 10 M E-64 in buffer A at 37 °C. The fluorescence intensity was measured at 450 nm on a microplate reader (INFINITE M1000 PRO). Excitation wavelength: 360 nm, emission wavelength: 450 nm, both slit widths were set as 20 nm.