For the best means to develop such a model, we maintained an open mind. Available to us was a dataset of analogues with their associated activities, whether against the parasite or derived from biochemical (ion-regulation and/or ATPase) assays. Many of these compounds were from OSM Series 4, and there were also candidate antimalarials from other, structurally unrelated, series. It was possible to include "presumed inactives": randomly-selected molecules from commercial catalogues that were unlikely to display activity. A homology model (vide supra) was available that might permit a more target-based approach. Acknowledging these varied resources, we opted not to prescribe the approach to be taken and instead, in 2014, approached the scientific community simply with the need for a model that would allow us to predict the activity of hypothetical compounds. All data from OSM research projects are freely available to anyone online, representing an ideal starting point for such an open competition.