We use the droplet microarray (DMA) as a platform for miniaturized high-throughput experiments. The DMA is an array of hydrophilic spots on a superhydrophobic background created by photolithography. It has proven as a potent platform for miniaturized chemistry and biology. Combinatorial library synthesis through a polymer-based solid-phase synthesis strategy to achieve synthesis of various structural motives has been realized and demonstrated for on-chip synthesis and screening. Our experimental synthesis workflow is based on the preparation of nanoliter sized hydrogels in the hydrophilic spots of DMA. For the analysis of those gels we use a non-contact method to measure UV-light induced timedependent degradation of soft polymers on a nanoliter scale through fluorescence microscopy.