In the case of SAA, the trapping probabilities are relatively high for SOM I, III, and IV. These systems exhibit a relatively low water diffusion (please compare to Figure ), which correlates with a higher probability of the molecules being trapped. In contrast, a low trapping probability is visible for SOM II, which is most likely connected to the high diffusion of SAA in this system, caused by the higher water diffusion. The strong influence of the diffusion of water on SAA is directly reflected in the probability of SAA being trapped in the SOM matrix, where water diffusion and trapping probability are anti-correlated. The results further indicate that the molecules do not follow a continuous diffusion, but rather go through sequential intervals of trapping and free diffusion. This behavior can only be observed using domain sampling methods such as MD simulations, which are facilitated by the coarse-grained representation of the molecules.