POCT integrated with capillary-driven microfluidic devices has gained widespread attention over the last decade . Traditional microfluidic devices usually require an external pump to drive fluid flow throughout the system . In contrast, capillary forces can be induced by the surface tension of the solution to drive the flow and devices exploiting capillary forces can operate in the absence of an external pump . As a result, POCT systems based on capillary-driven microfluidics have been implemented in various applications, such as the detection of heavy metals, pesticides, bacteria, viruses, biomarkers, and biomolecules . The most popular examples include pregnancy and COVID-19 test kits . These devices provide rapid results (typically within 15 min), require only a single drop of the running buffer for onestep analysis, are inexpensive, user-friendly, and portable but the flow control throughout the device must be accurate . With the aim of simplifying the device operability and improve its performance, we proposed a solution based on the lamination of multiples layers of transparent PET film and double-sided adhesive ( DSA) tape . This sensor facilitates automated fluid flow for washing the excess of targeted analytes and their detection by means of binders specific for C-reactive protein ( CRP) , but can be adapted to accommodate other capture elements specific for CRP or, potentially, any other (soluble) biomarkers.