In the next step of the project, we tested the reaction with substituted sulfamides 2 and 3. The Nmethylmorpholine solution was used to treat the reaction mixture in all cases. The reaction led to the formation of Biginelli-like products types 9 and 10. It should be noted that in the case of N-substituted product type 9 or 10 the NMR spectra has sophisticated character due to the slow inversion of the substituent at N(6) atom. We observed a similar picture for classical Biginelli products from N-aryl substituted ureas . Recording the spectra at elevated temperatures (up to 80 ⁰C) the spectral pattern becomes simplified and in accordance with proposed structure 9 or 10 (see SI, figures S6-5). In two cases the structure of the product was unambiguously proved by X-ray diffraction study. Significant pyramidalization of N( ) atoms (354 and 349° for Me and Ph substituents) could be highlighted among structural features of products. Compared with parent sulfamide 1 the reaction proceeds much slower, especially for Ph-substituted 3. In the case of these substituted sulfamides, we isolated the product 9ab from classical ethyl acetoacetate 4a for "good" p-methoxybenzaldehyde 5b as well as the product 9de based on "bad" acceptor aldehyde 5e. But despite the achievements, product types 9 and 10 were also prone to hydrolysis. Thus in the case of bromo-substituted aldehyde 5d, the corresponding product of hydrolysis 11dd was isolated in an almost pure state (Scheme 2). Scheme 2. Three component cyclization leading to thiadiazines using sulfamides 2 and 3.