In this study, we characterize the wetting behavior of water and its mechanistic origins on six chemically distinct commodity polymers (Fig. ): polytetrafluoroethylene (PTFE), polyethylene (PE), polyvinyl chloride (PVC), poly(methyl methacrylate) (PMMA), Nylon 66 (N66), and polyvinyl alcohol (PVA). By comparing results across different polymers, we broadly elucidate the role of surface chemistry, while additional selected systems are prepared to contrast behavior in crystalline versus amorphous (Fig. ) as well as atactic versus isotactic (Fig. ) systems. Across all systems, a variety of nanoscale hydrophobicity metrics are computed and compared to macroscopic experimental observations to assess the utility and relevance of characterizing hydrophobicity at the nanoscale with MD simulations.