The fitness criteria and their weight values (wv) applied here as preferences to select for children molecules were minimal docking-scores (wv = 4), molecular weights < than the 355 Daltons of PC190723 (wv= 2), cLog <2 (wv=1), and number of rings <3 (wv= 1). Each generation yielded 128 children molecules of which 8 survived to the next generation (default values). Usually, 50 to 150 generations per parent predicted ~ 0.6 to 1 % fitness to the multiple fitness criteria.