inhibitor synthesized with an IC50 value of 0.25 µM while moving the phenyl to the para-position (27) reduced potency by 3-fold. The improvement on AC1 potency for the 3-phenyl analog 26 also led to modest AC8 inhibition with 37% at the AC1 IC90, which was improved from the halogenated derivatives but not as selective as the 3-ethyl analog 20. To summarize, it appears that increasing lipophilic bulk is generally beneficial to AC1 activity, particularly at the meta-position while it is