Moving to water-assisted PT, we computed the reaction pathway with one (1w) and two bridging water molecules (12w). In addition, we also studied the reaction with the bridging water bonded to a second water acting as a hydrogen bond donor (1dw) and acceptor (1aw), as a prototype to study the influence of a water-wire mechanism on the ∆G ‡ (see Fig. ). As shown in Table , the ∆G ‡ values for the one-water bridged pathways 1w, 1dw