The determination of betamethasone 17-valerate in pharmaceutical preparations has been studied using a variety of analytical techniques in the past. These techniques include spectrophotometry, high-performance liquid chromatography (HPLC), and liquid chromatography-mass spectrometry (LC-MS). Chromatographic techniques provide a high degree of sensitivity and selectivity, but they can also be costly to use and take a while to analyze . On the other hand, spectrophotometry is a commonly used analytical technique that provides a dependable and affordable way to measure the medication in pharmaceutical formulations.