According to the findings from dehydrogenase activity, GSH, and ATP measurements, 5i and 5m caused the most profound cell impairment. In SH-SY5Y cells treated with both 25 and 100 µM 5i and 5m, we found significant decreases in dehydrogenase activity (p < 0.001), GSH (p < 0.001), and ATP (p < 0.001) levels after 24 and 48 h of treatment compared to untreated cells. These results are supported by photomicrographs of SH-SY5Y cells treated with 25 µM 5i and 25 µM 5m, showing a large extent of cell damage (Figure ) where SH-SY5Y cells exhibit spherical shape and cell density lower than in untreated cells.