In the case of the full pore, the interaction energy plays a large role. The general width (and loss of surface area) in the S-shaped, column bound configuration makes it a much less likely conformation in a full pore. Adjacent Sshaped, column-bound amines became crowded and detached (or nearly so) at one site. There are also strong interaction energies between all configurations when the pore is full, except for the linear, column configuration. This can be attributed to the compact nature of amine in this motif, as seen in Figure and the fact that the norspermine tends to have a position that is relatively unchanged between the single amine loading and the full pore.