The coupled-cluster method using singles, doubles, and perturbative triples [CCSD(T)] is the gold standard of single-reference quantum chemistry, for both thermochemistry and non-covalent interactions, yet this benchmark-level accuracy comes at near-intractable cost for systems with more than 10-20 non-hydrogen atoms. Efforts to develop localized-orbital approximations to canonical coupled-cluster theory are experiencing a renaissance, and among several competing approaches the domain-based local pair natural orbital (DLPNO) approximation has emerged as the most widely used variant, owing to its implementation in the ORCA software. The fidelity of the DLPNO approximation has been exhaustively evaluated for small systems, including for noncovalent interactions. However, there have been only a few systematic tests for non-covalent interactions in large systems. Neglect or approximation of distantpair interactions is known to degrade the accuracy in such cases. As a result, the accuracy of the DLPNO approximation decreases with system size, at least for thermochemical calculations. For benchmark-quality * ) herbert@chemistry.ohio-state.edu accuracy, results must be extrapolated to the canonical limit in which no amplitudes are neglected. Even so, recent work has demonstrated discrepancies exceeding 10 kcal/mol between localized-orbital approximations to canonical CCSD(T) as compared to fixednode diffusion Monte Carlo calculations. (See Ref. 49 for an up-to-date summary of state-of-the-art benchmarks.) Some of the relevant CCSD(T) benchmarks were obtained with the DLPNO approach while others used an alternative, localized natural orbital (LNO) implementation of CCSD(T), which is available in the MRCC program. All of these CCSD(T) benchmarks have been extrapolated to the complete basis set (CBS) limit, yet sizable discrepancies remain in multiple cases.