Different types of mass spectrometers are used depending on the analytical strategy and the objectives of a certain study, as there is a tradeoff between sensitivity and resolution of the instruments. Targeted workflows typically use sensitive instruments equipped with low-resolution mass analyzers, e.g. triple quadrupole. In contrast, untargeted workflows use instruments with lower sensitivity but high resolution, achieved with mass analyzers such as quadrupole-orbitrap or quadrupole-time-of-flight, leading to increased accuracy of the measured m/z values, which is critical in aiding identification. However, with recent developments in mass spectrometry, the sensitivity of HRMS is nearing that of LRMS, notably for low molecular weight compounds such as xenobiotics .