Remarkably, the current state of the automated laboratory landscape shows notable parallels to the early era of computer development in the 1950s and 1960s, where a multitude of specific devices, processing units, and workflows were developed with little flexibility and interoperability. Historically, this has inspired the development of standardized, portable operating systems (OS), which form the backbone of modern computer technology, and have enabled the widespread adoption of computer systems. The UNIX OS, arguably the most prominent class of operating systems, are based on three simple design concepts: (i) the development of small functional units for specific tasks, (ii) the robust inter-operation of these units and (iii) their inter-communication through plain text streams. Based on this UNIX philosophy, we propose ChemOS 2.0 (Figure ), a versatile, adaptable and portable "Operating System" for automated laboratories, fostering a holistic approach to operate and orchestrate various experimental and computational units. In analogy to computational operating systems, standardized plain-text communication protocols allow not only for the flexible integration of new software and hardware units, but enable the seamless interaction with human researchers. At the heart of our architecture is the integration of a fog computing device, offering improved efficiency and faster decision-making within the laboratory. Much like a traditional OS kernel, the fog computing device manages data, coordinates components, and empowers the lab to operate autonomously. We first describe the general architecture of ChemOS 2.0 along with its main design elements. Second, we demonstrate the applicability of ChemOS 2.0 in our own laboratory, showcasing the full orchestration of a complex materials discovery workflow towards novel gain materials for organic solid-state lasing devices.