to be toxic to Daphnia magna at concentrations of ~4-8 µM; though, bis(2,6diisopropylphenyl)carbodiimide was not tested. Additionally, this compound has been approved as an additive for plastics used in food-contact applications, indicating to an extent its perceived level of hazardousness. Searching other chemical databases for the potential compounds associated with PCL yielded some additional insights. Comparison to the PlastChem database revealed that the majority of compounds known to occur in PCL formulations and tentatively identified compounds in the extract are on the database's red list of chemicals that are not regulated internationally and considered hazardous by at least one criteria. Further comparison of the FACTORIAL bioassay results to the Attagene database of 6000+ compounds yielded no hits with similarity scores greater than 0.75 (Table ), suggesting the bioactivity was derived from compound(s) not in that