MN938385.1 SARS-CoV-2 virus isolate SARS-COV-2 _HKU-SZ-001_2020 ORF1ab was used to study the protein sequence and structural details. These peptides were studied for their physio-chemical properties using the tool Protparam . The secondary structure analysis was done using Chou and Fasman algorithm with CFSSP . To generate the 3D structure from the fasta sequence, homology modelling was performed and the templates were identified. Structural information is extracted from the template, sequence alignment is used to define insertions and deletions. Protein ligand interaction profile with hydrogen bonding, hydrophobic interactions, salt bridges and π-Stacking was done with PLIP server Blind Docking with ligands of the homology models generated from template 2a5i of the PDB database and template 3e9s of the PDB database and the also the templates 2a5i and 3e9s was done by docking the ligands to the whole surface of a protein using Autodock Vina The ligands and the protein molecules were taken in PDBQT format for docking. The preparation of the ligand and protein files was done by converting the SDF format to PDB format using