The TNKS2 case illustrates well the impact of manual intervention in generating appropriate poses when compared to those used for the P38α and PTP1B cases. Here, the reference results from Schindler et al and Gapsys et al studies do not outperform automated docking protocols in terms of agreement with experiment. This effect is likely due to the starting pose generation, where Schindler et al primarily relied on docking followed by a closer exploration of possible tautomers and multiple binding poses, yet no manual pose generation was attempted.