In contrast, exogenous addition of VEGFA (10 μg/mL) to cell culture medium stimulated tubule formation (Fig. ). Collectively, these studies support the hypothesis that TGP-377 affects phenotype via the miR-377-VEGFA circuit (Fig. ). This study further shows that sequence-based design of SMIRNAs via Inforna is a powerful approach to design bioactive compounds targeting RNA to affect a biological pathway specifically.