Expression of the cSeNP in an E. coli model system produces molecular contrast in electron and fluoresence microscopies, as well as cellular contrast in X-ray imaging (where resolutions are not molecular.) This paper demonstrates a 'proof of concept' using the E. coli, a workhorse laboratory model-organism. What is true in E. coli, often translates to more complex model and experimental systems. We are presently working to extend these findings to more complex model systems such as Drosophila.