Simulated performance and system sustainability varied widely across the 3,552 distinct combinations of decision variables and technological assumptions. Simulated steady-state rCOD varied from 14.5% to 93.8% across designs, with the 5th and 95th percentiles being 35.7% and 85.7%, respectively. Projected LC and CI had right-tailed distributions spanning 32.4 to 81,363 USD•tonne -1 COD removed and -80.0 to 18,347 kg CO2eq•tonne -1 COD removed, respectively (Figure ). Only 108 out of 3,552 designs were able to achieve negative CI for COD removal, whose LCs ranged from 32.4 to 848 USD•tonne -1 COD removed, lower than 65% of the evaluated designs. Therefore, specific combinations of design decisions had synergistic benefits for both financial viability and environmental sustainability.