Most biological processes are influenced or even governed by electrostatic effects. Structure-function correlations in general and ligand-receptor interactions in particular are heavily dependant on accurate electrostatic calculations. Just as the electrostatic contribution to the solvation / desolvation process has proved to be of paramount importance. However, the need for discriminatory case studies has not received the attention it deserves. The PB and GB models, provide very performant tools for modelling the effect of the solvent around the protein and they are widely used techniques for binding affinity estimation. The electrostatic contribution is modeled here as a dielectric linear response to the electric field generated by the atomic charges. There have been several previously reported promising results with excellent correlations with experimental data .