Dwell Time Analysis From the pair-pair interactions described above, we can additionally determine a dwell time for how long a specific interaction was present. A molecular simulation trajectory makes this straightforward, as we are tracking across trajectory frames for how long a pairwise interaction lasts before breaking. The python implementation depends on evaluating if a specific contact comes within 6 Å. Realizing that most interactions are short, we report the time-weighted cumulative distribution for these interactions, to better represent how long a specific interaction will last.