However, there are indications that the transition state is somewhat affected as well. The association and dissociation phases of the residence show almost complete symmetry (Supp. Figure ), pointing to cohesive modes of interaction. As HIP shifts are observed at the very beginning and end of the residence (i.e. the shallow depth of probe penetration into the cluster) , these findings further strengthen the assertion that the modes of interaction for both monomeric entry and exit are highly similar with a definitive transition state that is sensitive to compositional changes.