To further substantiate the release of ibuprofen and glycyrretinic acid in the cellular environment, we subjected cells treated with 2o-6k and 2n-6k to mass spectroscopy (Figure ). Our data showed that both drugs were detected in cells incubated with 2o-6k and 2n-6k for 10 hours, but at a lower concentration compared to those treated with free equivalent ibuprofen and glycyrretinic acid. The slower cellular uptake of polymeric 2o-6k and 2n-6k compared to their free counterparts was attributed to their hydrophilic nature and higher molecular weight. However, our results demonstrate that the hydrophobic drug moieties (ibuprofen or glycyrretinic acid) of 2o-6k and 2n-6k can be taken up by cells and released via the acid-triggered cleavage of acetal linkages in the acidic environment of endosomes, which are a nexus for endocytic pathways for foreign substances. Overall, these findings suggest that PEO-based drug carriers may have great potential for targeted drug delivery in various biomedical applications. Next, we explored the application of the PPM technique for synthesizing crosslinked PEO with degradability. We used dodecanedioic acid and performed PPM of PEO under identical conditions. The resulting product was a gel that was insoluble in acetone and water (as shown in Figure ). However, when the gel was treated with water, it gradually dissolved, and complete dissolution was achieved after 2 hours (as shown in Figure ). We are currently investigating the potential of this gel for use as a removable hydrogel patch and drug delivery.