P. falciparum protozoan species causing malaria, are transmitted by Anopheless and related species of mosquitos. Malaria infections start by intradermal inoculation of 10-100 gliding elongated unicellular circumsporozoites , which traverse surrounding cells to reach mammalian blood vessels and circulate to mammalian organs. Migratory circumsporozoites invade hepatocytes, become rounded and replicate to produce thousands of merozoites . Merozoites scape hepatocytes to penetrate blood erythrocytes , and further replicate causing clinical infections . Malaria affects millions of human infants in tropical regions causing deathly diseases.