Although there are numerous examples of Hofer-Moest reactions, the vast majority of cases have been reported on benzylic or α-heteroatom substituted acids (e.g. amino acids) for generating stabilized carbocation. Unactivated secondary carboxylic acids such as 59 is, in fact, a challenging substrate under conventional Hofer-Moest conditions. Encouraged by efficient decarboxylation of 59 under rAP-Kolbe conditions, generalization of the reaction was pursued. Interestingly, the decarboxylation efficiently proceeded even with slow alternating polarity of 5 seconds, and graphite electrodes gave the best result (68%). Although superiority of graphite electrodes in Hofer-Moest reaction is well-documented, the effect of alternating polarity in this reaction is hitherto underexplored. Careful studies to understand the role of slow alternating polarity indicated that modulation of electrode local pH, a similar scenario to rAP-Kolbe reaction, still operates to facilitate decarboxylation. Yet, no alternating polarity resulted in mostly no conversion or decomposition, highlighting the crucial role of switching electrode polarity. The optimized conditions are applicable to all class of carboxylic acids across primary, secondary and tertiary acids with good functional group tolerance. Most significantly, this reaction can be readily scaled