For the rate constants that involved the higher energy region α L , however, GaMD-WE performed better than WE. Figures and highlight GaMD-WE having the rate constants that go from α L to either primary metastable state α R or P II converge faster with smaller error bars (see Table ) compared to WE. GaMD-WE simulations with equal weights, on the other hand, did not perform better than either WE or GaMD-WE. As for the reverse rate constants that go from either primary metastable state α R or P II to α L , GaMD-WE and WE have comparable performances with GaMD-WE slightly underestimating both rate constants as seen from Figures and and Table . GaMD-WE simulations with equal weights performed marginally better than GaMD-WE by underestimating the rate constants lesser. This might be due to having higher weights for the regions of interest than GaMD-WE.