The comparison of this chemical space indicates that our self-developed HTE reactions encompass a breadth of chemical coverage comparable to that of the virtual space, which is recognized for its extensive coverage in reaction modeling. Although the does not capture the entire chemical space historically explored by chemists, it represents a robust and comprehensive starting point due to its open-access nature. This facilitates the replication of our study and underscores that our strategies to select substrates are effectively aligned with ensuring practical applications, which would benefit the development of a robust model.