In the subsequent stage, 5mg/ml of Curcumin is incorporated into the Calcium Nitrate Solution after which this solution is subjected to continuous stirring for 1 hour, allowing Curcumin to interact with the prepared ACP particle. During this step, Sodium Hydrogen Phosphate is gradually introduced into the mixture to facilitate effective loading of Curcumin into the nanoparticle. The stirring is continued for an additional 15 minutes at 30º C which ensures uniform distribution and integration of the Curcumin nanoparticles. The resulted suspension is then subjected to centrifugation that isolates the ACP -Curcumin nanoparticles, which can then be utilized for various biomedical approaches. The Co-precipitation approach is simple, cost effective and has a precise control over nanoparticle. However, the nanoparticle which are synthesized with the help of Co-precipitation method contains a large amount of adsorbed water and it is only applicable to charged species which limits its threptic application . Schematic diagram for preparation of curcumin nanoparticle by Co-Precipitation Method is shown in figure .