Flavonoids are a family of over eight thousand unique compounds that provide several advantages to plants. These compounds are responsible for some pigment and aroma of flowers and fruits, thereby attracting pollinators. Various flavonoids also protect plants from both biotic and abiotic stressors, 9,12, providing Fig. : flavonoid aglycones discussed in the present work A) hesperetin B) diosmetin C) quercetin Due to the ongoing pressing need for further COVID treatment strategies, we review the pharmacokinetic and putative frequent-hitting behavior of polyphenols' as a class with an eye toward ascertaining 1) their potential as an antiviral 2) whether or not polyphenols simultaneously should pose risks to ordinary healthy cellular processes.