The predicted ADMET properties and descriptors for the compounds are presented in Table . The aqueous solubility (QPlogS) is critical for the estimation of absorption and distribution of the compounds within the body and ranges between -5.45 and -11.05. A majority of the tested cannabinoids have solubility values out of the recommended range (compounds 2, 3, 4, 5). Cannabinoids with the ether functional group displayed poor solubility. QPlogHERG is another parameter that is out of the recommended range for compounds 1, 2, 4, 5. It is predicted that at halfmaximal inhibition, HERG K channel blockage can lead to arrythmia and cardiac adverse events . Most other descriptors are within the recommended range by QikProp ADMET software for 95% of known oral drugs . These results suggest that some of the tested cannabinoids exhibited acceptable physiochemical properties. These findings underscore the importance of thorough preclinical evaluation to ensure the safety and efficacy of novel cannabinoids before clinical use. Figure and 6 below visualizes the physiochemical characteristics of the pyrocannabinoids. In a previous study , non-clinical safety study was conducted on hydrogenated derivatives, with the cannabinoids failing hERG, but passing the Nav/Cav repolarization testing, passing the cardiac safety assessment. The score of the pyrocannabinoids generated by Schrödinger, are similar to the scores generated by SWISSADME as shown in SI figure and. The use of these software generates usable pharmacodynamic and physiochemical scores that describe the compounds properties, which is of importance and interest when identifying support for the synthesis of analogs treating diseases where the physicochemical characteristics can either increase or decrease efficiency of the drugs towards their desired targets. All cannabinoids as shown above in figure , are lipophilic and insoluble which although they pass the Lipinski rule of 5 minus one rule, challenges would need to be overcome which studies of making cannabinoids water soluble have been conducted .