The PMIS, ranging from 0 to 1, combines partial scores for 1) potency, 2) selectivity 3) activity in cells, 4) SAR data 5) availability of an inactive analogue and 6) a PAINS score. Nevertheless, probe suitability is not prescribed by the score value but by so-called minimum quality criteria. These include 100 nM potency in biochemical assays, 10-fold target selectivity, and 10 µM potency in cell-based assays (but not necessarily evidence of intra-cellular primary target engagement). The Probe Miner set of 3,187 compounds meeting these criteria thus have a PMIS between 0.38 and 0.85. A more detailed description is given in the Probe Miner publication. The PDPS, scaled from 0 to 1, incorporates partial scores in common with PMIS but adds in orthogonal probes. The comparison of both scoring schemes is shown in Table . Unlike the Probe Miner selectivity score, P&D also highlights target sub-family selectivity beyond just single proteins. The probelikeness of a compound is closely related to the PDPS value.