The combination of irreversible inactivation and multivalent glycan involvement suggests that the binding of lectins at multiple glycan sites causes conformational disruption of the Spike resulting in viral entry inhibition. This is similar to what has previously been reported for CV-N in the inhibition of HIV infectivity where a post-attachment role at a stage after CD4 binding was implicated . In turn, the capacity to cause irreversible inactivation, taken with the finding that lectin-driven inhibition of infection occurs with several SARS-CoV-2 variants, including Omicron, supports the potential of lectins for disease treatment. Indeed, such a usage is currently being evaluated .