The molar ellipticity of peptides were registered on a Jasco J-815 spectrometer (JASCO, Easton, MD, USA). Solutions of peptide hybrids were prepared in water solution, incubated at 37°C for 4h and then diluted to a final concentration of 0.20 mg/ml. CD spectra measurements were performed at 25°C, 30°C, 35°C, 40°C, 45°C, 50°C, 55°C and 60°C, at 190-260 nm wavelength and at a scan speed of 2 cm/min. The background of the solvent was subtracted. The results are presented as the relationship of mean residue molar ellipticity (MRME) [deg×cm 2 ×dmol -1 ] to wavelength . Measurements were performed in triplicate. In order to determine the peptides' denaturation temperatures, the molar ellipticity rotatory angle at a fixed wavelength of 196 nm, [θ]196, was measured as a function of temperature (max 100°C). CD temperature measurements were carried out up to a temperature of 100°C. Above this temperature, the cure was extrapolated with GraphPad Prism 8 software using the 4PL curve fit function. The denaturation temperature was determined as the temperature at which the change in ellipticity (θ) was half complete.