Both sire, and its derived programs such as BioSimSpace, are challenging to package and distribute. Being written in C++ presents challenges with respect to maintaining binary compatibility with other libraries, especially across multiple versions of Python and multiple operating systems. A design goal is that sire is easily installable, without compilation, on Windows, Linux and MacOS. In the past, this forced us to maintain our own binary Python distributions which were shipped as single "one-click" installer files. Fortunately, in 2012 Anaconda Python was released, and by 2016 conda-forge was in widespread use. Through 2017-2020 as part of the BioSimSpace project, we undertook the work needed to move to creating conda-forge compatible sire and BioSimSpace packages. Today, for each release, conda packages are built against the then-latest versions of all of sire's and BioSimSpace's dependencies from conda-forge. These are built for three versions of Python (currently 3.9, 3.10 and 3.11) for Windows, MacOS and Linux. Packages are built using GitHub Actions, with compilation there taking between 90-120 minutes to complete per package. The build is too long and complex to be supportable by conda-forge, and therefore sire and BioSimSpace packages are built by us and uploaded to the OpenBioSim conda channel on anaconda.org 55 .