While investigating the mechanochemical response of epoxy resins with the CoGEF method, we observed that the CoGEF prediction can strongly depend on the initial conformation and the density functional used. Therefore, in this contribution we present an evaluation of the functional dependence of the CoGEF method covering a broad spectrum of different mechanochemical reactivities and force ranges. The results indicate that multiple reactions or reaction cascades can become accessible at the high energetic regions typically observed in 1D-CoGEF calculations.