8-Aminoquinoline (8AQ) and 8-Hydroxyquinoline (8HQ) and their derivatives have found a great variety of applications in chemistry, from dyes to pharmaceuticals. 8AQ has also found application as a precursor for the synthesis of new potential therapeutic agents such as N4tetradentate copper ligands named TDMQ or bis-8-aminoquinoline derivatives Drug discovery and development is a very complex process demanding the implementation of multiple tools to test biological activity and safety of use. For example, to predict the transformations of drugs in the human body, it is important to investigate the redox activity of these drugs and to find a correlation between oxidation and reduction processes and pH. Typically, voltammetric techniques can be used to track such changes in vitro (e.g. cyclic voltammetry (CV), differential pulse voltammetry (DPV), or square wave voltammetry (SWV)). However, voltammetric methodology was seldom used as a tool for quantitative relationship studies between the chemical structure and biological activity of electroactive drugs based on 8AQ or 8HQ. So far, most articles concern the electrochemical properties of primaquine (PQ, an antimalarial drug) and its metabolites or prodrugs. Electrochemical studies were also conducted for Dibucaine, Hydroxychloroquine and Clioqinol. The newest studies combining spectroscopic techniques with voltammetry for a PBT2 (5,7-dichloro-2-[(dimethylamino)methyl]-8-hydroxyquinoline) analogue, an experimental drug candidate against Alzheimer's disease, showed why PBT2 shows insufficient effectiveness against this most common neurodegenerative disease. To better understand the electroactivity of drugs, it is useful to use model systems that represent the key structural motifs of the drugs i.e. conduct measurements for the core of their structure. Seminal works on HQ focus on both oxidation and reduction processes were investigated in order to study reversibility and free radical species formation. For 8HQ a two-electron irreversible anodic process controlled by diffusion was reported. Zima and colleagues also suggested the formation of various free radical species that form redox active dimers facilitating further oxidation processes leading to quinonoid-type compounds.