The majority of modern methods for target-based drug discovery rely heavily on sensitive and accurate quantification of target-drug interactions. To achieve this, a multitude of experimental procedures has been developed, including general-purpose techniques, such as surface plasmon resonance, calorimetry, microscale thermophoresis (MST), and mass spectrometry. These techniques can probe interactions between proteins and ligands of diverse natures. However, the versatility of these approaches often comes at the cost of lower sensitivity compared to targetspecific techniques. The latter commonly require specific probes, such as fluorescently labeled or radioactive ligands, which associate with particular binding sites on the proteins of interest and can thereby report their interactions with the small ligands.