The reaction continues with the cleavage of the C-OCH SPRINT metadynamics reveals also the existence of a distinct pathway (mechanism b), displaying analogies with the previous one, presented in Fig. . In this case the reaction proceeds through the following main steps: the initial formation of a SV (I-II) with a dangling carbon atom pointing towards the methanol; the double-functionalization of the dangling carbon by -H and OCH 3 groups originated by different methanol molecules (II-III); the healing of the SV with release of a CH 3 O -(IV-V); H migration between the Graphene layers (V-VI) until binding to the lower layer (VI).