The exploration runs conducted with PESmapping do not show a correlation between activation energy and the average computation time for a reaction. This is due to the fact that the CVHD energy bias effectively lowers all activation barriers, regardless of their initial height (see Fig. ). The individual computing times per reaction are considerably shorter than those from CTY-TAD. However, PESmapping simulations run completely in parallel and, as mentioned above, one out of nine parallel runs do not produce a reaction at all, which means that obtaining results quickly comes at the cost of unsuccessful excess computation time. The maximum runtime for PESmapping jobs is shown at 2 hours with a dashed line. Due to the hyperdynamics acceleration, the waiting times are scattered within an order of magnitude over a broad range of activation energies. The activation energies and their estimations as estimated with constrained and calculated with full ReaxFF/CHO2016 optimization are shown in Tab. 2 and shown in Fig. . The error in the estimation can vary significantly depending on the type of reaction. On average, estimated reaction enthalpies for barrierless reactions in the ĖF dataset are 38.5 kcal mol -1 lower than the actual optimized value. In contrast, the activation energies for reactions with a TS are underestimated by only 8.6 kcal mol -1 on average.