Polymers derived from natural sources are widely selected as good candidates in biological and biomedical applications due to their biodegradability and excellent biocompatibility. In addition, these materials often mimic the composition of native tissues by providing structural support and/or biochemical cues to cells, thereby promoting their biological functions (i.e, adhesion, migration, differentiation, signaling). The main natural polymers used in the formulation of hybrid hydrogels include proteins (e.g., collagen (COL), gelatin (Gel)) and polysaccharides (e.g., chitosan (CS), hyaluronic acid (HA), alginate (ALG), dextran (Dex), cellulose derivatives, gums). COL refers to a family of structural fibrous proteins abundant in the extracellular matrix of connective tissue. They are composed of polypeptide chains coiled together to form a triple helix structure. Type I COL (COL I) accounts for approximately 90% of the COL content in the body and is widely distributed mainly in skin, tendons, ligaments and bones. It forms thick fibrous bundles that contribute to a high tensile strength. Beyond its mechanical properties, COL I exhibits excellent biocompatibility and biomimicry, creating an environment akin to physiological body conditions. As a result, and thanks also to its biodegradability, COL I promotes cell attachment and proliferation making it a material of choice for hybrid hydrogels designed for tissue regeneration and wound healing. Accordingly, COL I-based hydrogels have