The working principle of these techniques is very similar to each other: phospholipids aggregate in solution in the form of thin films or larger vesicles and are then disassembled into much smaller vesicles. On the other hand, the polymeric fragment of hybrid nanocarriers is synthesized by techniques such as hot-high-pressure homogenization , nanoprecipitation , and emulsion solution-based production techniques . Since the fundamentals of some techniques, such as nanoprecipitation, are discussed in detail in the following sections, they are not discussed in this section. In the next step, these two components are combined in two ways: a) by adding polymer particles to the dried phospholipid film or b) by adding preformed polymeric nanoparticles to phospholipid vesicles formed during hydration of the thin lipid film . These two protocols have two important aspects in common: in both protocols, the self-assembly between the lipid layer and the polymeric nanoparticles is driven by electrostatic interactions . More crucially, both processes require vortexing or sonication at a temperature above the phase transition temperature of the phospholipid for CSHNs to form.