The enrichment map analysis gives curated signatures of protein sets generated from omics-scale experiments . Proteins involved in our immune system network were analyzed by using g:GOSt () to obtain significant annotations (false discovery rate -FDR < 0.001) related to the Kyoto Encyclopedia of Genes and Genomes (KEGG) signaling pathways, Reactome signaling pathways, and WikiPathways . Consequently, g:GOSt annotations were analyzed with the EnrichmentMap Pipeline Collection software to generate a biological process interactome network, which was visualized through the Cytoscape software v.3.7.1 .