There are several possible reasons for why the cached data reweighting did not speed up the training of the force field parameters. A breakdown for which percentage of the different types of properties were able to be computed from cached simulation data, as well as a breakdown of how much time was needed to estimate those properties by either simulation or reweighting cached simulation data, is shown in Figure . The overhead associated with attempting to reweight data points which then ultimately had to be simulated is included in green. c) The total time to complete each iteration when only employing direct simulations.