Taking in account the crucial role of SARS-CoV-2 (COVID-19 pandemic) and Zika main protases (Mpro) as infecting keys, alongside with the potent antiviral activities of the (MNPs) under examination, and as a part of our continuous program for identifying physiologically active marine natural products with potential antiviral leads , herein we report a comprehensive virtual screening of 39 lamellarins pyrrole derive marine alkaloids (LPAs) against SARS-CoV-2 and Zika main proteases (Mpro) using an integrated set of advanced computational and bioinformatics tools including (MDock), (MD) simulations and (SARs).