Both enhancements were run for 100 iterations, with a maximum time limit of 150 seconds, and a branching factor of 50. For primary testing, AiZynthFinder version 4.3 was used. The literature benchmark for the 50K ChEMBL dataset was 73% using the default parameters. We were able to replicate this with AiZynthFinder 3.7. We also tested version 4.3 with the same benchmark dataset, with two controls: iteration number and computational clock-time, and we used the ZINC and eMolecules stock files. The proportion of solved molecules was 76.4%.