RMLPs have been applied to reactions from small molecule gas phase scattering, to more complicated organic chemistry, and even to multiconfigurational photochemical processes. Meuwly's group has shown that RMLPs for single reactions can surpass classical reactive FFs in terms of accuracy . They parameterized classical MS-ARMD and a PhysNet model at the same QM level for a number of reactions and found that the PhysNet model achieves chemical accuracy while MS-ARMD usually have RMSEs higher than 1 kcal/mol. RMLPs for single reaction systems usually focus on a good coverage around minimum energy pathways (MEP) so that key properties such as reaction barriers and reaction rates can be accurately predicted.