Many people have struggled with mental health challenges during the COVID-19 pandemic and incidence of depression has increased in the US during the pandemic . Additionally, there is evidence that people with psychiatric disorders are at increased risk for COVID-19 infection , and that COVID-19 infection is associated with new diagnoses of psychiatric illnesses . Increased demand for the antidepressant drug sertraline has caused shortages throughout the U.S. . Sertraline levels increased in our analysis of daily sludge samples (Figure ). In our weekly sample analysis, the levels of three additional antidepressants (citalopram, amitriptyline, and doxepin), one antidepressant metabolite (desmethylcitalopram), and the antipsychotic drug clozapine increased (Figure , Table , Table ). No trend was observed for an additional 3 antidepressants and 3 anticonvulsant drugs (Table , Table ).