We performed CF-SMD simulations for a simple system of NaCl with water molecules (Figure ). NaCl was initially bound, and a constant force was applied to the center of each ion to enhance its dissociation. Figure shows that the dissociation time was distributed at each constant force. We predicted the dissociation time without a constant force (Table ). Further, we performed an equilibrium MD simulation (i.e., MD simulation without any external force) to compare the predicted time with the dissociation time at equilibrium, as a reference, (black triangle in Figure ) and provided a free-energy profile of the Na-Cl distance (Figure ). For further comparison, we produced a free-energy profile that provided the locations of the energy minima and activation barriers, which can be compared with the fitting parameters (Figure ). The global energy minimum was 0.26 nm; the activation barrier was ≈ 0.37 nm; the second minimum was ≈ 0.55 nm; the second barrier was ≈ 0.6 nm; the activation barrier height 𝛥𝐺 01 ‡ was ≈ 6.0 𝑘 % 𝑇. The distance from the global minimum to the activation barrier, 𝑥 01 ‡ , was ≈ 0.1 nm. Since we referred to the computational setting in an earlier study , the free-energy profile was almost identical to the previously reported profile.