The first version of LANaPDB had out with the same workflow employed in the first version of the database. The process was made in the Python programming language, employing the RDKit and MolVS modules. The standard curation process of MolVS was implemented through the standardize function included in this Python module: removal of explicit hydrogens, disconnection of covalent bonds between metals and organic atoms (the disconnected metal is removed later), application of normalization rules (transformations to correct common drawing errors and standardization of functional groups), reionization (ensure the strongest acid groups protonate first in partially ionized molecules), and recalculation of the stereochemistry (ensures preservation of the original stereochemistry). From the molecules that are fragmented, i.e., the molecules that used to be connected with metals or other salts, just the largest fragment is kept and is tried to neutralize all the molecules of the database.