All SMILES from the reaction entries collected to this point were processed with the ChemAxon-based Structure Checker pipeline. If any reaction component failed the structure checking the reaction was rejected. SMILES were then standardised using the ChemAxon-based Standardizer pipeline. SMILES of all the reaction components were converted into InChIs using ChemAxon. A reaction was rejected if any of the reaction components failed the conversion into InChI. The reaction schemes were then represented by strings of sorted reaction components as InChIs. The reaction records were deduplicated by retaining only the unique InChI-based reaction strings. The filtration, standardisation and de-duplication afforded 1.78M reactions.