Current output signals can be used to transduce the effects of the Ψo and CT with real advantages to multiplex the signal from many sensors. We calculated the transduction from a FET with a Fin of high-aspect-ratio geometry described in some of our previous works . We observed in the calculations that the current varies for different AAs depending on the type of immobilization (by the amino or carboxylic terminals). Here, we show the signal transduction of carboxylic immobilized A, R, C and D in the form of 2 nd gradient of the current with respect to the pH shown in fig. . The zero-crossover point of D between the minima and maxima correlates with the isoelectric point of the AA but the same doesn't hold for C due to a consistent increase in current without any significant charge transition for a larger range of pH as the difference in corresponding pK values for protonation and deprotonation (for C) is quite small as compared to D. As for the case of A, the current keeps on increasing till it reaches a saturation point leading to a maximum followed by a minimum of δI 2 /δpH 2 . A similar characteristic δI 2 /δpH 2 is followed by R with a right shift in the curve toward higher pH values due to decreased slope of potential with reduced current per pH sensitivity. Such signal transduction of the AAs is helpful in sensor array multiplexing that can enhance the scope of multi-AAs fingerprint detections while fine-tuning the device characteristics to negate the drift problem .