Cubosomes of both Pn3m and Im3m space groups, and hexosomes (plane group p6mm) were generated via compositional changes. We show that by adjusting flow rates used, excellent size control at low dispersity values can be achieved for the first time, aligning with typical trends for liposomal MHF. Particles were stable at 37 °C, required no additional post-processing steps and were characterised using a combination of dynamic light scattering, small angle X-ray scattering and cryo-electron microscopy. To investigate the loading efficiency of each particle type, two spectroscopic assays were included, using hydrophilic and hydrophobic cargo. Finally, to demonstrate the value of this unprecedented size control, we present a simple fusogenic study using two LLC size populations. Smaller particles were seen to deliver a fluorescent payload, whereas larger particles did not. Alongside this unique feature, we expect this platform to present an efficient and modular route toward rapidly prototyping LLC particles of diverse composition and morphology, essential for future uptake at an industrial level.