Over the course of optimization (Table ), a small amount of hydroxyselenylated product formed in select reactions, and this compound was stable to silica gel chromatography. We thus wondered if we could optimize the formation of this product (Scheme 3). Absent a tether, we were unsure whether perfect regiocontrol could be achieved with such a reaction. Amazingly, a simple replacement of 10-camphorsulfonic acid with 1 equivalent of NaHCO3 led to a complete reversal of product selectivity, now exclusively favoring hydroxyselenylated compound. Importantly, this product was a single regioisomer, stable to chromatographic purification, and easily isolable in pure form.