In total 147 compounds have been evaluated in this study. The most significant molecules -those that contribute most to an understanding of the SAR -are reported below, but all molecules are described in the Supplementary Information and may additionally be found in the online project infrastructure (). Twenty-four compounds were donated by the Drugs for Neglected Diseases initiative (DNDi) for which the experimental data have been published. An additional 36 compounds were contributed from Northeastern University, the experimental details for which may be found in a separate publication that has been recently accepted; 17 the compound identities are delineated in the Supplementary Information -Biology, Tables and.