With the aim to investigate the capability for post functionalization on the periphery of AL(DIPY)3 complexes and introduction of polar groups or palladium-catalyzed coupling reactions were tested (Scheme 2). First, ester hydrolysis of the 4methoxycarbonylphenyl derivative 13k was conducted straightforward yielding the corresponding carboxylic acid 16 in 95% yield. The presence of carboxylic acid groups can facilitate the biological applicability since they increase the solubility in more polar solvents. Moreover, the introduction of carboxylic acid group can act as an anchor side for further modification, such as bioconjugation.