Overall, the two models rank the 8,434,707 compounds differently with a Spearman's rank order correlation coefficient of -0.083. The number of AMS hits identified by the RF-C and Similarity Baseline models for different compound budgets. The RF-C performance is better than the Similarity Baseline for all compound budgets, and the gap increases with the budget. The budget is the number of top-ranked compounds evaluated. The total hits are the actives that would be found by screening only those compounds.