We applied Molecular Darting to an HIV integrase system with a set of diverse ligands. We chose HIV integrase in this study since this protein has three distinct binding sites ligands potentially bind to, leading to a plethora of potential binding modes that were hard for methods to discriminate between in a previous blind challenge. By using MolDarting we aimed to sample the various binding modes in the three binding sites in a single simulation. The ligands we tested were chosen from the SAMPL4 dataset to include a diverse set of ligands as well as a diverse set of three poses in each binding site, for a total of 9 different binding modes (Section 3.1.3).