Method TFE MLR was an empirical method that used a multi-linear regression (MLR) made from experimental log P values from 60 sulfonamides obtained from PubChem and DrugBank . The dataset was mainly composed of sulfonamide drugs and smaller molecules with other classical functional groups. The following descriptors were used to create the MLR: the frequency of functional groups, hydrogen bond acceptors, hydrogen bond donors, molar refractivity, and topological polar surface area. The functional group frequency was calculated with an in-house script from a modified function of Open Babel , the rest was obtained from supplied Open Babel properties.