The DNA's ability to form base pairs has brought numerous benefits to DNA nanotechnology. It is the most widely utilized molecular interaction in research studies and the design of DNA drug delivery systems. There are two methods based on this interaction, namely 'DNA tilebased' and 'DNA origami'. Due to some limitations, including being error-prone and timeconsuming of the former method, and also restrictions in controlling the stoichiometry and purity of DNA components in the designation of desired structures , the latter method has garnered greater attention which is introduced by Rothemund in 2006 .