Instead, all structures in a given set are grouped into analog series based on methods like matched molecular pairs with additionally deriving precursor structures using the RECAP (Retrosynthetic Combinatorial Analysis Procedure) rules. This way, the scaffolds extracted as representatives of an analog series take synthetic accessibility into account, an important aspect in medicinal chemistry but mostly ignored in the approaches above. The analog series and their representative scaffolds can be visualised by R-group tables, mapped into coordinate-based chemical space , annotated with activity information to support SAR studies, or used to extract favourable lead structures for drug design campaigns .