Second, Wesolowski and coworkers explored replacing the averaging over several FDE calculations for each snapshot by performing a single FDE calculation using an averaged solvent electron density . This way, the number of required quantum-chemical calculations of the molecular property of interest can be drastically reduced. It was shown that for the solvatochromic shift of the n → π * excitation of acetone in water, the effects of such an approximation are negligible. This observation was confirmed for the vertical excitation energies of protonated retinal Schiff bases in protein environments . Such a strategy was further explored by analyzing the solvent fluctuations and by comparing different methods for the construction of the average solvent density . Recently, the effect of averaging over different structures of the solute was also explored within such schemes .