The Medicines for All Institute (M4ALL) has recently reported a significant improvement in the conversion of starting materials 1 and 2 in the BA reaction. It was proven that higher conversion could be achieved by replacing LDA with less hindered/stronger lithium amide bases obtained from pyrrolidine, morpholine, or N-methylpiperazine (Scheme 1b). This modification in the methodology provided a substantial increase in the yield of the mixture of the syn and anti-diastereomers (3+ent-3+4+ent-4) (78 to 97 % assay yield).