Copolymers derived from N,N-dimethylacrylamide (copoly-DMA) have emerged as highly versatile coatings suitable for a wide range of applications . Notably, they have found extensive use in the development of microarrays and multispot biosensors on various substrates, as supported by relevant references . This class of copolymers offers rapid and durable surface adhesion , facilitating the covalent attachment of biomolecules while exhibiting excellent antifouling properties . The key precursor of these copolymers, N-acryloyloxysuccinimide (NAS), features a functional moiety that readily reacts with functional groups conducive to click-chemistry reactions, such as azide/alkyne reactions . Furthermore, click-chemistry reactions facilitate the biorthogonal orientation of immobilized probes .