However, templates are not always successfully applied. In Figure , two aromatic hydroxyl carrier fragments are involved within the same analogue species whilst query species 1 only contains one. This causes the template application to fail as there are too many reacting fragments. In other cases, involved carrier fragments in the same analogue species may be too far apart, resulting in the final fragment unable to be aligned with the query species. After accounting for template failure, 9,980 reactions remain, 4.2 % of the original analogue reaction set.