The electrostatic energy component, ∆ el E el,W ⊕C (z), is repulsive as a result of surface adsorption, and quantifies the electrostatic component of DS -head group water-desolvation due to adsorption (see the SI). The electrostatic entropy component, -T ∆ el S el,W ⊕C (z), is attractive, which similarly reflects DS -head group water-desolvation given that there is a greater destructuring of the surrounding water due to moving DS - from the bulk to the ACWI compared to moving DS 0 from bulk to the interface. Note that in taking the difference, -T S el+vw,W ⊕C (z) + T S vw,W ⊕C (z), we mostly remove the contribution due to transferring the solute cavity from bulk water into the C 12 E 6 monolayer, which is more or less similar between DS -and DS 0 surface adsorption processes.