The co-evolution strategy was developed in several steps: i) select the best parent molecules and cavities for DWBEL co-evolutions targeting the simplified Vif blue Vif red sA3G model with know anti-Vifs or star-like home-designed molecules, ii) generate thousands of DWBEL non-toxic fitted-children targeting the cavity interfaces of the Vif blue Vif red sA3G model, iii) select the top-children displaying the higher affinity consensus docking between two very different docking algorithms (DWBEL and ADV), and iv) study the influence of RNA by comparing the consensus top-children by ADV blind-docking targeting Vif blue Vif red sA3G±RNA.