The ADV blind-docked results predicted seven high-affinity L conformers that were named according to the identification number of star ligands: 20L, 21L, 23L, 24L, 25L, 28L, and 30L. Conformers 21L, 23L, 24L, 28L and 30L (Figure , orange and red), cross-docked CSP N-to C-terminal cavities (24 and 30 crossdocked the N and C-terminal α-helices), while 20L and 25L targeted only CSP C-terminal cavities (Figure , cyan). The L conformers did not predicted any docking to possible cavities within any of the CSP NANP-repeats. As expected, the highest affinities to CSP of the L conformers were low, reaching only ~ µM ranges. Nevertheless, the L conformers mentioned above defined possible CSP parents and cavities to start DWBEL co-evolutions to generate newly derived conformers predicting higher affinities.