The determination of API partitioning in aqueous and organic media is one of the key steps in developing new synthetic routes and to determine the bioavailability of the drug substance upon administration to the patient . When investigating new chemical processes, the partitioning of impurities and active ingredients is sometimes the costliest unit operation in chemical development . For this reason, the determination and modeling of this parameter during the early phase of drug development can accelerate and simplify the control strategy for process quality and robustness.