We used TanimotoCombo and TFD to identify molecules with dissimilar geometries in order to potentially identify molecules with parameter inconsistencies. We assign a "difference flag" to a molecule pair (in a "molecule pair", the comparison is made across force fields) when it yields a TFD value over 0.20 and a TanimotoCombo value over 0.50. These pairs visually exhibit different minimized geometries that may be indicative of parameterization differences. Out of 26,984,560 possible molecule pairs involving any pair of force fields, the combination of the SMIRNOFF99Frosst and GAFF2 force fields yielded the largest number of difference flags (305,582, Table )). This indicates that these force fields are quite different. In contrast, the combination of MMFF94 and MMFF94S yielded the smallest number of difference flags at 10,048 difference flags, indicating that these two force fields are the most similar among those being compared. These numbers are sensible given the history of these force fields -GAFF2 has undergone considerable recent reparameterization and SMIRNOFF99Frosst inherits parameters from parm@Frosst , a sibling force field of GAFF, while reducing the number of parameters with an entirely different form of chemical perception . In contrast, MMFF94 and MMFF94S are identical aside from their treatment of some nitrogen atoms consequently their optimized conformers should be rather similar, as reflected in our scores. Thus, these results match what would be expected from the parameterization history of these force fields. We also label molecule pairs with highly similar geometries. To do this, we assign "similarity flags" to molecule pairs that yielded TFD values under 0.18, indicative of similar geometries (Table ). In order to visualize the number of molecule pairs with each flag, we plot TFD versus TanimotoCombo for all molecule pairs. We highlight regions flagged as similar and different along with regions outside the interest of this analysis (Figure ). Figure likewise shows that the vast majority of molecule pairs were rated similar by both TFD and TanimotoCombo.