The activation energy distribution is shown in Figure . It demonstrates that backbones A, B, and D are distributed throughout a broad range of 0.8 to 44 kcal/mol, but backbone C is localized at the high activation energy range of 32.5 to 46.4 kcal/mol. The functional group impact on the activation energy is demonstrated in Figures . We discovered that -NMe 2 , -OMe, -OH, and -F, in this sequence, have the greatest impact on lowering the activation energies when directly bonded to the C atom of C=N=N. This effect is amplified when the aforementioned R-groups are simultaneously introduced to both substitution sites. As a result, backbones A and C have the highest and lowest sensitivity to substitution addition, respectively.