Plants are an important resource for discovering new antiparasitic molecules, with the well-known example of artemisinin isolated from Artemisia annua . Because of their particular properties as distinct from synthetic compounds (generally with more sp 3 carbons, chiral centers, or oxygen atoms), NPs are more pertinent to biological targets and have higher hit rates in drug discovery screening programs compared to compounds of synthetic origin . However, obtaining new drug candidates from natural sources also comes with challenges: their structural complexity makes NPs difficult to synthesize, and the quantity and diversity of molecules in natural extracts (NE) make them challenging to comprehensively characterize.