The amino alcohol nucleophile (0.25 mmol) was dissolved in 0.5 mL of H 2 O and the pH of the solution was adjusted to 9.5. G>P (0.025 mmol) was then added, the pH was readjusted to 9.5, and the solution was heated at 40°C unless otherwise stated. The progress of the reaction was monitored by P-NMR spectroscopy.