In this study, we address the imperative need to quantify the contributions of the nucleophilicity-swing and pH-swing mechanisms. The first two sections lay the foundation for this exploration. Firstly, we provide a thermodynamic overview elucidating the interplay between these mechanisms, emphasizing how the dominance of one over the other necessitates specific molecular engineering considerations in the material discovery cycle. Secondly, we delve into a case study focusing on BTMAPAQ, extracting both thermodynamic and kinetic insights for its three isomers. This case study highlights that, beyond thermodynamics, the kinetics of these mechanisms can differ, thereby influencing the dynamic interplay between them. Building on these foundational sections, we introduce two in situ experimental methods for quantifying the contributions of these mechanisms in the system. The first method relies on discerning the voltage signature differences between the quinone and the quinone-CO2 adduct. The second method introduces a powerful non-invasive, in situ method based on fluorescence microscopy, offering the capability to distinguish between the oxidized, reduced, and adduct species and quantify their concentration with sub-second time resolution at single digit micrometer resolution through their fluorescence signatures, demonstrating a highly promising technique for studying such electrochemical systems.