While other non-thermal chemical drivers can target specific frequencies and bond vibrations, mechanochemistry can directly strain systems along particular reaction pathways, opening up a host of new reaction tools. As reaction barriers can be calculated from the energy needed to displace (strain) a system from the ground state configuration to the transition state configuration, it is only natural to think that strains that project along possible reaction coordinates can lead to driving otherwise unfavorable reactions. These mechanochemical reactions can be premeditated, such as utilizing single molecule force spectroscopy to apply strain to a specific covalent bond, or they can be extemporaneous where a downstream material process triggers stochastic intra-molecular strains that induce or influence chemical reactions. Subsequently, mechanochemical reactions can be dichotomized as mechamochemically driven or mechanochemically assisted, with the former being a bond deformation until breakage, and the latter as a bond strain accelerating or altering a thermally driven reaction. Shockwave induced reactions are a prime example of the latter, where the shock heats the material hundreds to thousands of kelvin and can induce large intra-molecular strains. Mechanochemistry is becoming widely relevant in engineering and industrial applications such as force responsive materials and mechanochemical green engineering. In fundamental chemistry, mechanochemistry is utilized for a wide variety of purposes such as for driving exotic and/or forbidden reactions, for developing new synthesis routes, and for minimizing the amount of energy and/or eliminating solvent needs to incur reactions. A striking example of this is mechanochemistry allowing for ammonia production under significantly lower temperature and pressure conditions. Significant theoretical work has explained experimental trends, yet there is still a significant knowledge gap in the fundamentals of strain influenced reactions, especially in batch processes and condensed matter. In condensed matter cases, many-body mechanochemistry comes into play, where the strains are non-linear, characterized by bending and twisting of functional groups. It is critical to understand how these deformations map their strain energy back onto the reaction coordinate, as the amount in which the strain drives the system towards the transition state can well determine the effective activation energy of the deformed system. 11,48 A simplified formulation for how mechanical strain can lower the activation barrier considered the force applied on some reaction coordinate