The discrepancy between the two patent sets can be rationalized by the time-period over which the data was collected. The USPTO dataset accounts for reactions published up to September 2016 whereas Pistachio includes reactions until 17th Nov 2017. Further differences in the Pistachio and the public USPTO set arise from the inclusion of ChemDraw sketch data, and text-mined European patent office (EPO) patents which are included in Pistachio. The sketch data may be missing agent and condition details, as they are 'as drawn', and do currently not incorporate information from the accompanying text. Therefore, species that contribute a changing atom or bond may be absent and would not be incorporated in the template extraction. As this information cannot be included in the templates, the reaction is discarded, and no template is extracted.