Due to their optical properties, aromatic thiols, such as benzenethiol (BT), have become popular SAMs. SAMs formed with BT has been established as disordered, with inconsistent tilts of the phenyl ring, as both sp and sp 3 hybridised sulphur atoms existing in the monolayer. As with alkanethiols, if a long chain is substituted in the para-position, interchain interactions will increase leading to a more densely packed monolayer. Alternatively, benzenemethanethiol (BMT) which has an alkyl spacer group between the sulphur and phenyl group, forms a stable, orientated monolayer, similar to that of an alkanethiol. This is due to the favourable sp 3 hybridisation of the sulphur atom in BMT, causing a 104° angle with the surface to the S-C bond, respectively, and allowing a densely packed monolayer. Another common derivative of BT is aminothiophenol (ATP), which has an amine group, allowing attachment to a biorecognition element, as demonstrated by Billah et al. Vert recently, Białobrzeska et al. reported the development of an impedimetric biosensor for clinical diagnostics of SARS-CoV-2 based on selective nucleocapsid N protein detection. Researchers modified the gold surface with 4-ATP in order to obtain an amine functional surface. Then gluteraldehyde was used as a crosslinker to immobilise the anti SARS-CoV-2 nucleocapsid antibodies.