To demonstrate the PMF convergence acceleration, we studied the dissociation of the salt bridges interface within the CD2CD58 complex. This system, made of several salt bridges and hydrogen bondings interactions, was already studied by some of us. Although it has been shown that PFFs allow a better description of the salt bridges interactions, their computational cost has long hindered the study of such large system. Since the portability of Tinker-HP on multi-GPU and the global acceleration of the PFFs, reaching such system is now easily achievable. To start this study we took the same CD2CD58 complex as in our previous work but we solvated it in a waterbox of 100 × 100 × 100 Å. Counterion were added to neutralize the system. We used the AMOEBABIO18 PFF. The system was minimized with a RMS of 1 kcal/mol in the NVT thermodynamic ensemble with the Bussi thermostat. Temperature was set to 300 K while pressure was set to 1 atmosphere. We used the multiple-time-step BAOAB-RESPA1 with a 10 fs timestep with the Hydrogen Mass Repartionning scheme (HMR) and Smooth Particle Mesh Ewald (SPME) algorithm to compute electrostatic and polarization interactions with a real space cutoff of 7 Å and a Van der Waals cutoff of 9 Å. The convergence criteria for polarization was set to 10 -5 .