Nitric oxide (NO) is one of the major pro-oxidant molecules, necessary for multiple physiological processes . Its functions are mediated mainly by its nitrosylating effects for specific proteins or the oxidation/nitration of others following Generally, • NO is a small diatomic molecule and its biological half-life in vivo is less than a second. Moreover, because it is less soluble in water than in non-polar solvent, the cell membranes have high permeability to • NO, where it can perform different functions . In addition, the • NO molecule is characterized by its low ionization potential, where its unpaired electron in the outer μ* anti-bonding orbital can easily be lost . Hence, • NO molecules can interact with other molecules containing unpaired electrons, representing a strategy for quenching • NO and controlling its levels in the body. Naturally, this occurs via • NO-scavenging by cell-free oxyhemoglobin, myoglobin and oxymyoglobin . Accordingly, through the delivery of certain molecules able to scavenge • NO, the migration of TNBC cells can be modulated.