Determination of Rink Amide resin loading 10 mg of resin was weighed into an Eppendorf tube, to which 800 µL of DMF was added. After allowing the resin to swell for 15 min, 200 µL of piperidine was added to the suspension; at this point the tube was vortexed and allowed to stand for 15 min at room temperature. Afterwards, the tube was centrifuged and 100 µL of the supernatant transferred to a 1 cm path-length cuvette and diluted with 900 µL of DMF. The absorbance at 301 nm was measured versus a blank, which was prepared with the same procedure but without the use of the resin. The concentration, c, of dibenzofulvenepiperidine adduct released from the resin was determined by applying the Lambert-Beer law [ A= c ], where A is the absorbance value, is the path length (1 cm) and is the extinction coefficient of the dibenzofulvene-piperidine adduct (7800 mL/mmol*cm, λ = 301 nm). Average values resulted from three independent experiments. Finally, the loading, L, was calculated using the formula: