Nanoparticles can be decorated with polycationic brushes that can capture genetic materials to be delivered upon internalisation, presenting different core chemistries for imaging or to control degradation . These nanomaterials, once loaded with oligonucleotides or plasmid DNA, can then be delivered to cells for evaluation of transfection efficiencies . A range of different brush design parameters have been found to play crucial roles in regulating transfection efficiencies. Hence the grafting density and thickness of brushes was found to modulate the binding and infiltration of oligonucleotides and, in turn, the knock down efficiency of siRNAs .