Although, currently, TFA does not have as well-established health advisories or regulatory limits other PFAAs , it is likely that new advisories/limits will be introduced in the coming years as more research on the impacts of TFA emerges. With the projected exponential increase in TFA concentrations in the environment , food and in humans, the question is not if TFA can exceed a planetary boundary, but which irreversible health or Earth system impacts would be first observed at a planetary scale, and where thresholds of TFA emissions should be set to limit the severity of such impacts.