In the first part of this perspective, we introduce how the different approaches, that are used to create nanosensors affect the scalability and develop categories for high throughput methods (synthesislimited/selection-limited). In Section 2, we discuss the main building blocks that are required for nanosensors and how they in turn affect the throughput. Section 3, provides examples that showcase progress in synthesis-limited approaches as well as open questions and challenges for the future. In this context, we also provide a detailed summary of corona phase molecular recognition approaches and discuss how selection-limited approaches can further increase throughput. Finally, we provide our 1.