In the partitioning studies, seven organic solvents were selected. These solvents are immiscible with water to ensure that bi-phasic partitioning conditions could be met: octanol (OCTL), cyclohexane (CYHL), ethyl acetate (ETAC), heptane (HP), methyl ethyl ketone (MEK), tert butyl methyl ether (TBME) and dimethylformamide (DMF). Comparison of cyclohexane-water vs. heptane-water logD can show the effect of conformational flexibility . We can learn about how modeling accuracy is affected by homogeneous and heterogeneous organic solvent phase by comparing the prediction performance for cyclohexane -water and heptane-water logD values to octanol-water logD values. Comparative evaluation of ethyl acetate, MEK, and TBMEwater logD predictions can lead to conclusions about how models handle solvents with different polarity and hydrogen bond acceptor groups.