The catalytic dehydrogenation of light alkanes can convert abundant and low-cost hydrocarbons to high value-added chemicals. In this way, it is possible to meet the demand of compounds in the chemical industry and facilitate the transition from petroleum to natural and shale gas, which contains large amounts of ethane and propane feedstocks. In addition, ethylene is a key building block to synthesize various downstream products, being the chemical substance with the largest production per year. The most active pure metal catalyst for light alkanes dehydrogenation to obtain light alkenes, such as ethylene or propylene, is platinum. However, platinum tends to fully dehydrogenate hydrocarbons. Consequently, coke deposits are built on top of the catalyst, hindering any further reactions. Furthermore, small nanoparticles and nanoclusters of platinum tend to sinter into larger particles, leading to a decrease in the catalytic performance. In metal nanoclusters most or all of the catalytic metal is reactant-accessible, hence improving the use of precious metals. Nevertheless, the thermodynamic instability of such small nanoparticles is more pronounced and they are more likely to sinter. Great efforts have been devoted to fight these deactivation mechanisms. For example, the use of a chlorine atmosphere to redisperse the catalyst or applying an overcoating oxide layer. The regeneration of the catalysts can be also done by periodically oxidizing the coke away at high temperatures. However, the high temperatures trigger sintering.