h⊕t,W . For both V = W and V = W ⊕C, we show the change in the total solute-solvent energy, ∆tE h⊕t,V , and entropy, -T ∆tS h⊕t,V , as solid purple and green lines, respectively. Additionally, we show the tail components of the change in energy, ∆tEt,V (the average tail-solvent energy for the fully-coupled DS -, ⟨Vt,V ⟩1), and entropy component, -T ∆tSt,V , as dashed purple and green lines, respectively. solvation energy in bulk water), while the entropic term, -T ∆ t ∆ C S t,W ⊕C , mostly accounts for the difference between introducing the tail cavity within bulk water and introducing the cavity into the monolayer.