We next wanted to push this approach by demonstrating that complex reaction mechanisms involving the sequential generation of multiple radical species are compatible with a solvent-minimized methodology. To this end, we selected the cross-electrophile coupling of aryl and alkyl bromides mediated by a XAT agent, such as tris(trimethylsilyl)silane (TTMSS). 12 Our model reaction system included 1a and Bocprotected 4-bromopiperidine (2e) as the coupling partners, sodium carbonate as a base, [Ir1] as the photocatalyst, and [Ni1] as the nickel co-catalyst, Figure . Using 2 equivalents of 1,2-dimethoxyethane (DME) as a LAG agent and a 2-hour reaction time, we found that auxiliary loadings of 12, 15, or 18 equivalents of sodium sulfate afforded similar yields (56-61%), while the use of 21 equivalents of auxiliary led to a moderate decrease in yield (44%). The removal of the LAG agent also led to a significant reduction in yield (31%), while increasing the LAG loading from 2 to 3 and 4 equivalents gave comparable yields (61-64%).