Second, while Martini 3 lipids show compatibility with protein-lipid interaction patterns observed with Martini 2 lipids, further validation is needed. Martini 2 has been extensively tested for diverse protein-membrane systems, but forthcoming improvements in Martini 3 protein models, such as improved side chain thermodynamics and structural flexibility, will require re-evaluation of these interactions. A systematic assessment of the Martini 3 lipidome together with updated Martini 3 protein models will be essential to ensure compatibility across a wide range of systems. In this work, we have established a set of test cases that could be iterated in future parameterization work, and we encourage the broader Martini community to report both positive and negative results of the protein-lipid interactions studied.