Under the 𝒮 𝑚 ℬ 𝑛 partitioning approach to the Polytope Formalism of constitutional isomerism, the same set of connectivity permutations apply to the three distinct examples in Figs. . Consequently, for each of these examples in Figs. , the resultant number of families and species are identical and equal to 6 and 49, respectively. The different symmetry combinations of the site and bonder complexes will, however, lead to these species being distributed into different numbers of genera. In the limit where there is no site symmetry, the number of genera equals the number of species with each genus containing a single species (a "monotypic" genus). This will be discussed and demonstrated later. The examples in Figs. 5e and 5f feature molecular systems where the bonders are located inside the site complex. The example in Fig. is set up to describe tautomerism in free-base subporphyrin (free-base triphyrin[1.1.1]) where the bonders (Hatoms) can connect to any of the three sites (N-atoms). These sitesand the entire site complexexhibits D3h symmetry. Fig. shows a B2OF2-porphyrin complex partitioned as the 𝒮 4 ℬ 2 class to investigate the strepsisomerization 1 bond-walk mechanism. The four sites (N-atoms) and the macrocycle ("porphyrindiyl") exhibit D4h symmetry. The two bonders are the B-atoms with the O and F-atoms as spectators of the bonder complex.