Mechanochemistry involves the chemical transformation or synthesis using mechanical force such as grinding, milling, or shearing. This technique often involves little to no solvent, lower reaction times, lower reaction temperatures, and high atom economy making it a highly desirable green chemistry method. In the past few decades mechanochemical synthesis has been expanded to several areas of chemistry such as inorganic, organometallic, organic, pharmaceutical materials, and inorganic-organic hybrid materials. The increased popularity and progress of mechanochemistry makes it an exciting area of chemistry yet, there is still much to learn about the fundamental aspects of reactivity of mechanochemical processes. Progress has been made to better understand process effects for example milling time, intensity, force, and temperature. In-situ and solid-state analysis have been used to widen the scope of understanding the mechanics of mechanochemical reactions. For example, in-situ measurements using thermography, x-ray diffraction, Raman spectroscopy, and a combination of these, have found great success.