Overall, these simulation results are very promising, but prompt further investigation. The tremendously improved docking scores require rigorous testing to rule out possible docking artifacts. The case of Tyrosyl highlights target specific problems which require either a specialized scoring function or a different approach to generate the custom chemical libraries considering charges of resulting molecules. Furthermore, the synthetic accessibility needs a more thorough investigation, since this is a major bottleneck of evolutionary algorithms and generative methods in general in CADD. Finally, we noticed a ten times increased overlap within individual runs as well as between runs. This might point towards a smooth energetic landscape converging towards similar molecules, which would also partially explain the highly improved docking scores. Again, this also requires further investigation that, however, are outside the scope of this contribution.