We fitted the dissociation time data using Bell's and DHS models (Figure ). To evaluate the accuracy of the predicted dissociation rates without a constant force, we compared those predicted by the DHS model with the rates 𝑘 +,, 01 calculated by long-time equilibrium MD simulations in an earlier work 4 . Our dissociation rates agreed well with those reported in an earlier study (Table ). For 1D7H (DMSO-bound), our dissociation rate was 96.52 × 10 2 s )* , whereas that of the earlier work was 59 × 10 2 s )* . For 1D7I (DSS-bound), our dissociation rate was 75.71 × 10 2 s )* , while that of the earlier work was 21 × 10 2 s )* . For 1D7J