In terms of the induced dipoles, we found that the unphysical boundary polarization results in large errors along the outer boundary regardless of the type of molecular system. In aqueous solutions, the errors quickly diminish when moving away from the outer boundary due to the small polarizability of water. However, for the biomolecular environments, which contain highly polarizable parts, such as lipid molecules, we observed relatively large errors also deep inside the simulation box. The errors in the induced dipoles translated to substantial errors in the induced electrostatic potentials at the quantum subsystem and, thus, the capability to critically affect its properties. However, our results also showed that the errors in the potential tend to cancel out when considering the average of several statistically sampled configurations.