Chat GPT successfully determine the smiles of Tylenol (Acetaminophen), hence it can be used to covert one file format to another. The Chat GPT answer was "The chemical name of Tylenol is Acetaminophen and its molecular formula is C8H9NO2, its Simplified molecular-input line-entry system (SMILES) notation for Tylenol is "CC(=O)NC1=CC=C(C=C1)O". This notation represents the atoms and their connections in the molecule." 3. Generation of input files for gaussian and other software: Chat GPT successfully produces the input file for gaussian software. The input file is shown in Figure . 6. Can give FASTA sequence but cannot compare the FASTA sequence: In this case ChatGPT was unable to suggest the FASTA sequence. However, to suggests that the fasta sequence can be obtained from the UniProt database.