Like many other CSP approaches, we separate the sampling of molecular conformational degrees of freedom from that of the lattice degrees of freedom. To validate the conformer generation method, the CSP test set was enriched with examples from the CSD drug subset with 9 or fewer rotatable bonds from Z'=1 crystal structures. In total, the dataset consists of 430 experimental crystal conformers. The RMSD of the results from the conformer generation protocol are presented in Table in SI. The conformer generation protocol reliably samples conformations within a RMSD of 0.40 Å compared to the experimental ASU for all molecules in the Z'=1 CSP test set. Due to the exhaustive nature of our method, high quality conformers are always generated across the chemical space tested, even for large flexible molecules.