Finally, it is important to acknowledge the inherent limitations of coarse-grained modeling, which also apply to the Martini 3 lipidome. For instance, the entropyenthalpy compensation limits the transferability of the lipid models to state points other than those used in the parametrization process. The entropy-enthalpy tradeoff also substantially complicates reproduction of certain delicate processes like bilayer pore formation, where free energy barriers are too high in Martini . While the reparametrized Martini 3 lipidome slightly improves this property over Martini 2 (Figure ), the free energy profile of pore formation is still significantly larger compared to atomistic models. Furthermore, although the current Martini lipidome can capture phase transitions quite well, in general, capturing temperature dependent behavior will remain challenging. A temperature-dependent approach, as suggested in earlier works , could mitigate some of these issues and improve the robustness of