The complexity of TLRs has consequences in the relatively weak understanding of the structural basis of their modes of action. Therefore, significant effort is required to comprehend TLR dynamics, both at the level of particular domains, full-lenght receptor and the dimerisation process. Here, in the first part, we gave an outline of the studies that examined the effect of certain mutations on the receptor's dynamics. In the second part, we summarised the works that focused on the characterisation of the dynamical properties and conformational changes of fulllength TLRs.