Electrocatalysis has only recently become a practical tool for organic synthesis through a vibrant renaissance building off the pioneering work of Perichon, Shono, Little, Yoshida, Moeller, , and others. Electrochemical oxidation or reduction allows precise tuning of reaction conditions to match substrate needs and limit side reactions from classical reagents that operate in fixed potential windows. The electrocatalytic strategy represents an eco-friendly and economically sustainable method because it provides a more selective source of electron transfer as opposed to chemical reagents, generates less waste, and works under mild conditions. Electrochemistry and electrocatalysis have advanced significantly over the last ten years, with improvements in instrumentation facilitating implementation in both academic and industrial settings. An academic-industrial collaboration between our labs at Bristol Myers Squibb and Baran's lab was established to advance Ni electrocatalysis in the context of drug discovery. The collaboration with Baran's lab quickly led to the identification of general platforms for electrochemical Ni-catalyzed C(sp 2 )-C(sp 3 ), C(sp 3 )-C(sp 3 ), and C-O cross-couplings.