Because the absence of any ORCO-volatile compound 3D complex solved monomer structures, to generate parents and docking cavities for DWBEL co-evolutions, previously identified volatile compounds 23 21 were selected for ADV blind-docking. Four volatile compounds of molecular weights between 116 to 222 g/mol were selected from the most recent ORCO Aedes sp antagonists identified by computationally prediction and in vivo confirmed assays 23 21 . ADV blind-docking to the Anopheles ORCO monomer model predicted ~ docking affinities of: 214 µM (Hexanoic), 65 µM (Geraniol), 55 µM (Nilalylacetate) and 6 µM (Nerolidol). More data of the selected volatil compounds were provided at the Supplementary Materials / HGNN.dwar.