In summary, we show that mechanochemical acceleration of thermal reactions can be successfully modeled via an extended version of the Arrhenius equation that treats the mechanical influence as an applied strain energy cast onto the normal modes of the molecule. These normal modes represent an orthonormal basis set in which to succinctly describe any intramolecular strain state. From this theoretical form, we derive the conditions in which, under a constant total input energy, it is preferable to utilize a mechanical strain to a purely thermal reaction. We show that perturbations in molecular shape can result in significant relative change in the kinetic rate constant, but that these changes become more disperse for large energy inputs where more preferable mechanochemical states exist.