The activation of compound 10 to the corresponding heteroaryl chloride 11 was performed in the same manner as described above. However, to avoid the use of column chromatography on scale, it was found that quenching of the phosphorus oxychloride and related phosphate analogues using an inorganic base such as sodium hydroxide or carbonate allowed for an efficient removal of these species. The crude solid obtained after solvent removal could then be triturated in iPrOH increasing its purity to above 98%. Using this new isolation protocol, the compound 11 was isolated in 96% corrected isolated yield, a considerable increase from the 78% yield obtained via column chromatography on silica gel. The final SNAr reaction with (R)-3-(1-aminoethyl)-2methylbenzonitrile hydrochloride was performed using the same protocol described above.