In this total synthesis, the mixture of atropisomers 25 and 28 (1:1 mixture) generated via Larock macrocyclization was directly utilized in subsequent reactions leading to the formation of lapparbin (1). Consequently, it was initially anticipated that lapparbin (1) would be synthesized as an atropisomeric mixture (1:1). However, intriguingly, contrary to initial expectations, the 1 H NMR spectrum of the synthesized lapparbin (1) exactly matched the isolated lapparbin (1) reported by Oh and Kim et al. (see the Supporting Information). This experimental observation suggests that during the transformations of Larock cyclized products 25 and 28 into lapparbin (1), atropisomer convergence occurred. Specifically, while the cyclized products 25 and 28 are atropstable enough to be isolated at room temperature due to the high rotational barrier of the atropisomeric axis, it is hypothesized that Sa atropisomer convergence occurred during the removal of the bulky TES group and the phenolic Me group in the transformations into lapparbin (1) This implies that the axle chirality (Sa) of lapparbin ( ) is thermodynamically stable. Notably, the conversion of both atropisomers 25 and 28 into lapparbin (1) without loss suggests that the Larock macrocyclization strategy is highly efficient. To further elucidate the specific process at which atropisomer compounds following Larock macrocyclization. However, obtaining a clear NOESY spectrum was challenging due to the rotamers and conformational isomers characteristic of peptide compounds, which obscured the spatial correlations of the protons.