In recent years, the direct and selective conversion of alkanes into fine chemicals has garnered significant attention within the scientific community. This surge in interest stems from a growing desire to introduce sp -character into organic molecules, which matches more with the 3D-nature of protein targets, thereby enhancing their efficacy and reducing attrition rates. Moreover, direct activation of aliphatic C-H bonds allows practitioners to bypass the use of functionalized molecules, such as haloalkanes or organometallic reagents, enabling the direct use of feedstock materials into the late-stage modification of drugs, agrochemicals, and materials. Notably, gaseous hydrocarbons stand out as the most abundant, atom-efficient, and economically viable carbon-based feedstocks. Despite their prevalence, the C-H bonds present in these molecules exhibit extraordinary inertness, rendering conventional synthetic methodologies for converting gaseous hydrocarbons into functionalized derivatives often ineffective or lacking in selectivity (Scheme 1A). As a consequence, gaseous hydrocarbons are predominantly utilized as energy sources in combustion processes.