Sustainability analysis of any treatment technologies evaluates their environmental, social, and financial impacts. Quantitative Sustainable Design (QSD) is a structured methodology used for accelerating and supporting the research, development, and deployment of technologies. QSD integrates concepts from sustainability science and engineering to facilitate the creation and implementation of sustainable solutions. A critical step in QSD is defining the problem space, which includes the selection of variables or parameters that influence sustainability, i.e., decision variables, technological parameters, and contextual parameters. Previous studies on the sustainability of PFAS treatment technologies primarily focus on GAC and IX. PFAS Length Single Use IX Resin