To conclude this discussion, the contribution of each term of the dissolution enthalpy in Eq. 7 is further analyzed. The dissolution enthalpy is calculated using the four thermodynamic processes involving C p,s , ∆H sub,298K , C p,g , and ∆H solv,T , respectively. The individual contribution of these terms to the predicted solid solubility is plotted as a function of temperature for four solute/solvent pairs and presented in the supporting information (Figure ). From the the plot, it can be seen that the contribution from the C p,s and C p,g terms (heating of the solid-and gas-phase solutes) is much smaller than that of the ∆H sub,298K