incubation. An example of the results after hemin and H-Tyra incubation for 16 hours is shown in supplementary figs. 35,36. This relates to the enhanced aggregation of hemin in the medium as explained previously in the dimerization study section. However, some changes were observed, especially at the incubated 20 μM solutions of H-Tyros and H-Styr. Here, a decrease in • NO concentration was observed following the injection of 8 μM from each solution (supplementary figs.