The work focused in the most important mosquito malarian vector Anopheles coluzzii (Anopheles gambiae sensu strictu). Anopheles was chosen for the ORCO amino acid sequence model (XP-312379).The 478 amino acid sequences of Anopheles and Aedes (NP_001345400) ORCOs differ only by 12.8 % and their 3D models by 0.126 Å). The amino acid changes implicated in anti-ORCO bindings are restricted to residue 162 L or F for Anopheles and Aedes, respectively. The present studies were focused to the Anopheles ORCO. The corresponding 3D structure was modeled in SWISS Model using the 6C70.pdb from Apocrypta bakeri ORCO as template . Their monomers were isolated in PyMol and targeted for DWBEL and ADV.