Like in any other rhabdoviruses, the gpGVHSV is the only viral protein targeted by neutralizing host antibodies and the most used vaccine targeted . In salmonids, intramuscularly injected DNA-vaccines coding for gpGVHSV as well as for other gpG fish Novirhabdoviruses, have shown 80-100 % protection against homologous rhabdoviral challenges. The success of these prevention methods allowed the approval of the APEX-IHN DNA-vaccine for salmonid farming at North America . However, similar DNA-vaccines against other fish rhabdoviruses have not been equally protective (i.e., SVCV in carp). There are no high-affinity therapeutic drugs approved to stop rhabdoviral outbreaks in salmonid farms.