Thus, 2010 -2011 became the borderline where the formation of the concept of nanotoxicology was formulated. The UK launched a voluntary reporting scheme for nanomaterials in 2008 that targeted manufacturers, importers, and users (Department for Environment . However, after 1 -2 years, such requirements from the USA, EU, Australia, and Canada authorities have become mandatory . This was facilitated by the understanding that not all concepts in chemical safety can be readily translated into nano-sized objects .