Rapid modernization were the most important contributors to water pollutants for the duration of the world. nowadays, pharmaceutical residues detected in the μg/L-ng/L variety in surface water,groundwater, and consuming water resources are considered as emerging contaminants due to the extended opportunity of improvement of superbugs. A recent newspaper article has pointed out the presence of superbugs in the river Ganga, a primary river in India. some other article has highlighted the pollution due to antibiotics in rivers everywhere in the international, with the concentrations often exceeding the threshold limits. nearly 90% of the antibiotics are excreted in their determined form from the human body, which subsequently reaches the sewage treatment plants . The considerable assets of antibiotic residues because of the anthropogenic activities are partially treated or untreated effluents from sewage treatment flowers, hospitals, and pharmaceutical manufacturing industries.Fluoroquinolones, carbapenems, and cephalosporins are the maximum generally said class of antibiotic residues in the effluent treatment vegetation of India. Ampicillin belongs to the fluoroquinolone magnificence of antibiotics, and they're used to treat a variety of bacterial infections. Their presence in water bodies has been suggested in the range of 5,000-31,000 μg/L and 251,000 μg/L, respectively . The predicted No-impact concentration-minimal Inhibitory concentration (PNEC-MIC) for the prevention of growing resistance is postulated based on the technique endorsed by Bengtsson-Palme and Larsson and by way of the Antimicrobial Resistance (AMR) Industry Alliance (2018). The PNEC for ampicillin is 0.4 μg/L . The capacity adverse results of those antibiotic residues are vegetation irrigated with contaminated water ends in bio-accumulation within the food chain (from the farm to the table and then into the human body), the aquatic existence is affected due to quandary of the mild penetration, sewage drains get clogged with the bacterial biofilms due to the accumulation/sorption of antibiotic residues onto the sewage sludge, and the switch of pathogenic (antibiotic-resistant) genes into wholesome microbes promote an growth in superbugs . therefore, there is a pressing want to deal with these wastewaters. diverse physical, chemical, and organic remedy methods like membrane strategies, reverse osmosis; activated carbon, chlorination; cardio, and anaerobic strategies had been in existence for the remedy of pharmaceutical wastewaters. The fundamental drawbacks of these remedy methods are clogging of membranes, carbon regeneration, obstacle of size exclusion range, disposal problems (physio-chemical remedy), biomass accumulation, sluggish technique, and requirement of long startup intervals (biological treatment). due to the poor degradability of antibiotics and the unsuitableness of wastewater remedy plants to deal with that pollution, there's a need for the improvement of opportunity sustainable remedy methods . Photocatalysis, with the potential to degrade the organic contaminants in water and wastewater, serves this cause . Semiconductor-based totally photocatalysis is one of the superior oxidation processes (AOPs) for the removal of organic contaminants via the generation of powerful oxidizing marketers . TiO2 is the maximum broadly used photocatalyst as it's far effectively available, non-poisonous, chemically, and mechanically solid. but seen light usage because of the huge bandgap of 3.2 eV is a prime quandary. the usage of seen mild active photocatalysts is gaining importance in recent times, which may be executed through engineering the bandgap of semiconductors through doping. diverse metals (transition-Fe, Cu, Co, Zn, Mn, Mo, Ni, W; rare earth-Ce, Gd, European, Y; and others-Li, Ge, Si, Sn, Pb,) or non-metals (B, C, N,S, P) help in narrowing the bandgap for effective usage of visible light, and gives splendid chemical stability .it's miles glaring that the presence of rising pollution mainly antibiotic residues in water bodies and the ensuing linkage to the increasing antimicrobial resistance is of great challenge and on this context, it'd be suited to have a seen mild photocatalyst that is simultaneously effective for each photo-degradation in addition to disinfection. preserving this goal in mind, the dopants are narrowed down to cerium (Ce) and boron (B) for the reasons said below. uncommonearth metallic doping like cerium results in the narrowing of the bandgap and promotes the adsorption capacity for this reason, enhancing photocatalytic hobby by way of providing better touch between pollutant and photocatalyst. Ce-TiO2 photocatalysts had been suggested for the degradation of phenol, chlorophenol, polyvinylpyrrolidone, and methylene blue and disinfection of Staphylococcus aureus. some of the various non-metal dopants, B ions occupy both the substitutional and interstitial lattice positions of TiO2, the former position facilitates in narrowing of the bandgap, introduction of new power ranges and transferring of the absorption part closer to visible light even as the latter role promotes effective electron-hollow separation and reduces the recombination rate. it's also a powerful disinfectant . B-TiO2 photocatalysts were suggested for the degradation of p-nitrophenol, Orange II azo dye, and disinfection of Staphylococcus aureus and Escherichia coli. other than those, photocatalytic degradation of antibiotics (ampicillin) and dyes (Rhodamine B, RhB) had been suggested via the use of l. a./Cu/Ze trimetallic nano photocatalyst BiOBr/BiFeO3, and Sr/Ce/AC bimetallic nanocomposite respectively. numerous strategies for the synthesis of doped photocatalysts like sol-gel, hydrolysis, hydrothermal, solvothermal, and co-precipitation have been pronounced. The EDTA-citrate technique affords a higher catalyst yield and additionally improves the properties of the catalyst debris. EDTA forms a hoop structure with a maximum of the metallic ions and enables the molecular level of mixing. there's little or no or no literature on the synthesis of Ce-TiO2 ,Ag-TiO2 and B-TiO2 using this method. The photocatalytic degradation of ampicillin by means of TiO2 was studied , and a few researchers have mentioned the usage of doped TiO2, BiOBr and Fe debris . A summary of the research carried out on the photocatalytic degradation of ampicillin is provided in tables S9 -S10 of supplementary. in this manuscript, the photocatalytic degradation of ampicillin under sunlight with the use of a series of B,Ag and Ce-doped TiO2 photocatalysts synthesized by the EDTAcitrate approach has been finished at the side of the photocatalytic disinfection of E.coli. The precise stress MTCC 9541 used for the disinfection examination is remoted/derived from the river Ganga in view of the full-size antimicrobial resistance present in this river .