To assess whether 38 could reduce pain sensitization we evaluated the analog in a mouse model for inflammatory pain with CFA as previously published. Compound 38 was injected intraperitoneally (i.p.) at a dose of 5.6 mg/kg and was compared to 5.6 mg/kg morphine (positive control) and vehicle (negative control). Mechanical allodynia was quantified by von Frey filament testing recorded pre-CFA injection (no allodynia), 24-hr post-CFA injection (0 min, allodynia), and over a period of 2 hours post-treatment with 38 or morphine. Compound 38 displayed modest, yet statistically significant, anti-allodynic effects in this inflammatory pain model at 1-hour posttreatment compared to the 0 min (allodynic) time point (Figure ). Morphine produced a more pronounced anti-allodynic effect throughout the time course. A B