The selected molecules with potential bioactivity were and 279 since they have ideal properties in terms of gastrointestinal absorption, oral bioavailability, they are not substrate of glycoprotein P. Likewise, these compounds do not significantly affect the isoforms of CYP450 responsible for the metabolism of xenobiotics. The LD50 of these 5 molecules is in an equimolar dose with nifurtimox, which allows to have a wide range in a possible antichagasic therapeutic scheme. As a weighting factor for their selection, it was considered that they are not hepatotoxic or nephrotoxic compounds, compared to nifurtimox.