Metal-based compounds have a broad range of applications in different scientific areas from chemical catalysis to clinical applications. The synthetic accessibility and the creation of low-toxic metal-based compounds open new perspectives for their use in modern therapeutic and diagnosis proposes. Nevertheless, pharmacokinetics and pharmacodynamics properties will be the main challenge to solve during future decades, for example, reducing the high rate of ''off-target" interactions and improving their subcellular and tissue selectivity, in addition to the limited bioavailability. Despite the challenges, medicinal inorganic chemistry has contributed to the creation of a broad list of metallodrugs used for multiple clinical applications from diagnosis to treatment of chronic and infectious diseases.