In summary, while both TMA and ADTA have been studied widely for decades, CSP calculations indicated that there were promising unknown porous crystal structures for both molecules. A number of these predicted phases were subsequently discovered in the laboratory using a HT method to rapidly screen hundreds of different crystallization conditions. This integrated CSP / experimental screening strategy greatly accelerated the discovery of these new materials: indeed, they would likely have remained undiscovered without such techniques. CSP can tell us whether to look and, if so, what to look for: this is a huge advantage over 'blind screening' approaches.