Prior to predicVng the size-exclusivity of the potenVal solvents, we first validated the results of the solubility screening workflow by ensuring the scrambled 3 3 :13 -R POC mixture met a minimum solubility threshold of 200 mg + 1 mL. This concentraVon was selected as this was the solubility used in previous studies to compare PLs formed from the same scrambled POC mixture and corresponds to the 'good' solvent category in the HSPiP input set. See SecVons S2 and S3 for a detailed descripVon of syntheVc and analyVcal methods.