Rimantidine binds exothermically to all of the hosts tested here, and its binding enthalpies are 2-5 times greater (more negative) than those of methylcyclohexanol for the corresponding hosts. However, rimantidine binding is disfavored by negative entropy changes in all cases, in striking contrast to methylcyclohexanol, for which the entropy change uniformly favors binding. The combination of rimantidine's more favorable binding enthalpies and more unfavorable binding entropies, relative to methylcyclohexane, suggests further entropy-enthalpy compensation, and this is confirmed by the scatter plot in Figure (orange points).