221 formols (compounds containing the ROCH 2 OH motif) were also found in the network, as was just one with a methylenedioxy motif (R 1 OCH 2 OR 2 ). Such formols form readily from reactions of HCHO with various nucleophiles, but the formation of amine and amide formols was not included in the reaction model as these compounds often form reversibly and with low equilibrium constants, and there is little available data to benchmark how common such structures are in real reactions.