For a molecule of this size, the cost of hybrid DFT is dominated by Hartree-Fock exchange and only minor timing variations are observed amongst different functionals, despite the higher-quality grids that are needed for mGGAs. For medium-size molecules there is hardly any computational advantage to using B3LYP as compared to modern mGGAs, although that assess- ment can be skewed by timing data in low-quality basis sets. For example, a ωB97M-V/6-31G(d) calculation for C 41 H 50 O 6 N 4 is 3.3× more expensive (per SCF iteration) than a B3LYP/6-31G(d) calculation, but ωB97M-V/ def2-TZVP is only 1.2× more expensive than B3LYP/ def2-TZVP.