TPhP, TPyP and TBAP all have multiple low-energy conformers, which required us to expand our CSP and ESF map methodology to consider the ensemble of possible conformers to ensure that the crystal packing arrangements are comprehensively sampled and that experimentally realizable structures are not missed. For conformationally flexible molecules, it is not obvious which form will crystallize experimentally; indeed, observed crystal structures are sometimes based on molecular conformers that have high energies in the gas phase. This means that a wide range of conformers must be considered during CSP.