24-para-Toluene-sulfoxy-5-Cholane-3-ol (3) Dissolved the 5-cholane-3-24-diol (2.5 g, 6.9 mmol) in THF (15 ml) and cool to 0 o C. Added 1.8 mL (1.4 g, 13.8 mmol, 2.0 eq) of triethylamine and followed by 2.63 g (13.8 mmol) of 4-Methyl-benzenesulfonyl chloride. Stirred and maintain at 4 o C for 72 h. Remove the solvent on rota evaporator. Extracted with ethyl acetate (100 mL X 2) and washed with 10% NaHCO3 solution, brine solution, dried over MgSO4 and filter. Concentrated under reduced pressure on rota evaporator to give a residue which was purified by column chromatography by using 30% ethyl acetate in hexane, to obtained 1.0 g of product in 50% yield. During this time, precipitate is formed, and solution is turned to red in color. Removed the DMF solvent on rota evaporator to get residue and quenched the residue with water. Extracted with ethyl acetate to remove excess of reagents. Filtered the aqueous layer to remove urea side product formed and unreacted acid compound. To aqueous layer (contains essentially pure product) add ammonium hexafluoro phosphate to get precipitate, concentrated the aqueous layer to half of its volume and cool in freezer to and filtered to get 250 mg of solid product in 95% yield. Ruthenium, bis(2,2'-bipyridine-kN1,kN1')dichloro (11): To a solution of 2.5 g (9.5 mmol,1.0 eq) of RuCl3.3H2O and 2.75 g (61 mmol, 6.4 eq) of LiCl in 25 ml DMF was added 2.94 g (19 mmol, 2.0 eq) bipyridine at room temperature. Heated at reflux for 45 minutes, while continuously check the tlc for emission under uv lamp. Cool to RT. Poured into 100 mL of acetone. After cooling in freezer for 24 h, ppt is formed. Filtered and washed with water and acetone until pale color appeared. After 2 h dry in vacuum, obtained 1.9 g of product in 40%