Marine invertebrate-derived natural products (NPs) play a crucial role in their survival by providing chemical defense against the hostile marine environment. These compounds also exhibit a wide range of biological activities, including antimalarial, antitumor, anti-inflammatory, and antimicrobial properties. Significantly, a number of bioactive compounds from marine invertebrates have been successfully developed into clinical drugs, such as ziconotide, eribulin, and plitidepsin .