In contrast with Martini 2, Martini 3 displayed an interaction propensity between the peptides so low that no discernible predominant dimer structures were observed (Figure ). This did not change when the peptides' secondary structure was restrained by an elastic network instead of angle/dihedral restraints over consecutive residues (see Supplementary Figure ) -the elastic network alternative is able to maintain the helices supercoiled, though for peptides this short the structural difference is still small. Even when Martini 3 peptides did transiently come into contact, they did so mostly via regions other than the correct dimerization interface.