In this work, we use a ligand exchange process to synthesize a series of ZnSe(L) LHs to elucidate the extent to which ligands can protect these compounds from degradation in ambient conditions, and to suggest a mechanism by which they degrade. ZnSe(L) with the linear ea, ba, ha, oa, da, dda, eea, and boa ligands can be successfully produced by ligand exchange with high (> 90%) exchange yields. In contrast, cyclic amines bza and amch exhibit modest extents of ligand exchange. On exposure to humid environments, the longer alkylamine ligands slow degradation compared to the shorter ligands.