One of the primary objectives of this work is to utilize a minimal number of descriptors while ensuring they possess physical interpretability. To achieve this, we have used only six descriptors: polar surface area, hydrogen bond donors, hydrogen bond acceptors, the number of rotatable bonds, logP , and an electrostatic term which we call as the pol term (GB term summed with Coulomb electrostatic). The first five descriptors were calculated using the RDKit 46 package in Python, while the last descriptor is calculated as described below. The simplified polar energy is the sum of two terms, the Coulombic electrostatic energy, and a generalized Born energy term. The generalized Born energy term is calculated by the Generalized Born equation as follows