Fragments fulfilling the RO3 showed noticeable differences. For example, LANaPDB's "Fragments RO3" (Figure ) had the most fused bicycles and macrocycles (sixteen different and unique fragments with 0.01 % each one and around ten atoms). LANaPDB's fragments had more bridged bicycles (three different and unique fragments with around 0.01%) than LANaPDB's "Fragments RO3."