All BD were performed using the Browndye 2 program. As with OpenMM, all simulations were prepared and controlled through the SEEKR API. Interior dielectrics were set to 4, while exterior dielectric constants were set to 78. All atomic positions, charges, and radii were reused from the previous SEEKR-MMVT study. The APBS program was used to compute electrostatic grids. Desolvation forces and hydrodynamic interactions were enabled for all calculations, and other physical quantities (such as viscosity, solvent radius, etc.) were left at their defaults.