Previous approaches to CS oligosaccharides and associated building blocks have utilised trichloroacetimidate (TCAI) D-GlcA donors, namely a pre-glycosylation oxidation strategy. Whilst proven and undoubtedly useful, issues due to low reactivity of uronate donors and the possibility of donor-derived side product formation (e.g., orthoesters or Ntrichloroacetamides) are notable considerations. Here we instead opted to explore a postglycosylation oxidation approach (D-Glc to D-GlcA) using thioglycoside donors (shelf-stable and generally synthesised in fewer steps than TCAI donors). Previously, Lei and co-workers established a post-glycosylation oxidation strategy to synthesise CS-E oligosaccharides using TCAI donors to access a key disaccharide for iterative synthesis. 27