To establish other first solvation shells, one can either eliminate or insert water molecule(s) from the 17H 2 O configuration. While the elimination mechanism results in an unconnected noncovalent network, the insertion method is found to maintain the network and increase the number of hydrogen-bonds proportionally to the number of added H 2 O. In other words, at least a total of seventeen water molecules is required for a highly connected hydrogen bond network as shown in Figure . As an illustration of the insertion method, we doubled a single water molecule in pose A of the 17H 2 O configuration (yielding two water molecules in pose E) to obtain an 18H 2 O configuration (see the resulting hydrogen bond network Figure ).