However, the use of higher RC schemes also results in a decrease in the number of available reference species that can be used to construct the isodesmic reactions. Consequently, the calculated enthalpies of formation become more dependent on the uncertainties of the remaining reference species. As a result, a trade-off emerges: As we move to higher RC schemes, the uncertainty due to the computed enthalpy of the reaction decreases, but the uncertainty due to the individual reference species increases. While we have included the uncertainties of the reference data in the database we compiled, the present manuscript focuses primarily on the general evaluation of the IDR approach and its comparison with BAC methods. A more sophiscated uncertainty and sensitivity analysis that involves Monte Carlo simulations or alternative weighted optimization methods is beyond the scope of this work.