Using the simple alkane stability score model to predict the stability scores of experimental small molecules across five categories, we observe from the pairwise accuracy results (Fig. ) that it correctly ranks molecular stability in at least 81% of pairs across different classes. This surprisingly high performance can be attributed to most pyrolysis processes below 900 • C without catalysts or reagents following a free radical elimination mechanism that is similar to alkane pyrolysis regardless of the specific degradation reaction kinetics. This suggests that relative stability tends to depend more on structural molecular features, such as length and branching that are accurately captured in the alkane dataset, than elemental composition.