As a result, the approach of patterning fluidic features atop the multi-ridge ATR crystals is most amenable to an open channel architecture. In the sole work that was successful in sealing the channels on top of the top-side patterned device, the world-to-chip interface dominated the space requirements, leaving very little space for channels and analyte monitoring. In the current work we propose a different strategy, whereby the ATR crystal is embedded into the microfluidic device. As we show, isolating the sensing to a specific region on the resulting spectrofluidic device reduces wasted sensing surface area previously used for structural support of the device. This unlocks significant potential for on-chip chemical sensing applications by removing limitations on device sealing, world-to-chip interfacing, fluidic manipulations, and device complexity. We demonstrate the freedom in microfluidic device design by incorporating multi-ridge crystals into 4 fundamentally different device architectures. In addition, we couple the devices with the previously mentioned aperture scanning accessory to conduct proof-of-concept measurements in assaying, continuous scanning during dynamic changes to flow conditions, visualization of concentrations gradients, and to follow on-chip reaction kinetics.