We optimised four different scoring schemes to support users for probe triage and selection. As explained, the Probe Miner (PMIS) and P&D probe-likeness scores (PDPS) are datasupported. The other two scores are expert opinion-based and thus more subjective. These are abstracted from the Chemical Probes Portal Rating for use in Cells (CPOC) and in Organisms (CPOO). These represent a summed rating of chemical properties, primary targets, secondary targets and in most cases, expert judgments. The conceptual difference with datasupported scores is that these are calculated for compoundtarget pairs. Thus, a single compound can have multiple scores against each of its assigned targets. Users may thus select the most suitable of these pairings but the probes can also be used for intra-or inter-family selectivity. For comparability, all scores are normalized to between 0 and 100%.