We repeated the relative binding free energy calculations on the data set described in previous work. Comparing to the Schrödinger FEP/OPLS 2.1 force field, GPU TI with AMBER FF14SB and the GAFF force field performs reasonably well on this data set, with errors above those seen using the FEP/OPLS 2.1 force field. For the 330 mutations, AMBER has MUE and RMSDs of 1.17 kcal/mol and 1.50 kcal/mol, which is comparable to Schrödinger's 0.90 kcal/mol and 1.14 kcal/mol. For the 199 ligands, most of the binding free energy values are within 2 kcal/mol, except 18 ligands and 5 ligands for AMBER and Schrödinger, respectively. Future work will explore the use of replica exchange and other new features in AMBER to enhance the sampling (both in λ-space and orthogonal degree of freedom), compare capabilities of the next generation GAFF2 and possibly other force fields, and test procedures for creating benchmark quality results with meaningful error estimates that can be used as a baseline for other comparisons.