FtsZ. The Filament Temperature Sensitive Z-ring proteins of bacterial cell division (i.e., Staphylococcus aureus) are important targets to develop novel antibiotics against increasing resistances . The reference antistaphylococcal PC190723 inhibitor binds FtsZ but at low µM ranges , often causing pharmacological problems and bacterial gene resistances . TXderived drugs/prodrugs (Taxis pharmaceuticals, Monmouth Junction, NJ, USA) are being developed to overcome such issues, but no affinity improvements have been yet reported . Previous attempts to find new FtsZ docking candidates by large computational screening, identified ~ 100 new inhibitors of bacterial cell division but only at µM affinities . PC190723-derived DW-BEL children at nanoMolar affinities were described in our previous work , including some validations by bacterial eNTRY globularity rules for drug bacterial cell wall penetration . Toxicity Risk was not available.