GNPS I , an innovative way of exploiting GNPS spectral library, was developed during this work (Section 4.6). It revealed able to significantly enhance the annotations available on which our recommendation is based. Beyond MS2DECIDE, we foresee that this methodology could serve as an inspiration for routine annotation of NP extracts. We are not aware of other teams using iterative approaches such as ours to query GNPS and we highly recommend it to maximize the extraction of usable data from this valuable source. Its use in our case permitted to triple the number of hits returned by GNPS (Supplementary Section 2).