In the past two decades, there has been a growing interest from the materials science and nanotechnology communities in the possibility to modulate the electronic, mechanical, and chemical properties of 2D carbon-based materials by inducing changes in their atomic topology. Two main approaches have been adopted: doping and strain application. High-pressure conditions have been shown to strongly alter the topologies of multilayer graphene, leading in some cases to the formation of new 2D materials with unique electronic and mechanical properties. For example, under high pressure, few-layered graphene systems immersed in liq-uids/solids have been observed to undergo transitions into thin diamond-like structures and/or exhibit chemical doping. Recent studies based on Diamond Anvil Cell (DAC) experiments 2 have provided evidence for the formation of a new "diamodene" phase from bilayer graphene (BLG) in ice at 5-10 GPa. A chemical-induced scenario has been proposed, where the functionalization of BLG layers by water molecules (-OH and -H groups) at 5-10 GPa triggers the formation of C-C interlayer bonds.