One way to integrate a bio-feedstock into chemical supply chains is through production of bulk chemicals or of molecules easily transformable into bulk chemicals. However, a wrong choice may lead to system-level problems, such as incompatibility of scales (availability of feed vs demand for bulk chemicals), increased demand for 'waste' triggering increased production of other materials, and so on. Another option is to synthesise molecules that can be used in especially short multi-step reactions, that is to directly access complex molecular functionality from bio-feedstocks and avoiding building it up in the conventional petrochemical supply chain. Both possibilities may ensure a high contribution of the biobased molecules in the overall chemical supply chain. Either way, we can say that a biofeedstock should enter a reaction network in an optimal location -be transformed into strategic molecules.