In the unbiased runs comprising 2 NPs, the hydrophobic SASA changes abruptly upon dimerization (see Figure ). Figure shows the percentage decrease of the hydrophobic SASA upon dimerization for all MUS, MUS:OT 2:1 and 1:1 NPs. There is a clear trend: the more OT in the shell, the less the hydrophobic SASA reduction upon dimerization.