are highly oxidized, rearranged tetranortriterpenoids that have garnered significant attention from the synthetic community due to their complex structure and potent biological activities. C-seco limonoids are an important class of these natural products where cleavage of the C-ring of a steroidal precursor provides distinct core structures. Hundreds of these limonoids have been isolated to date. Compounds such as nimbolide (1), nimbin (2), 10 salannin (3), and azadirachtin (4) typify the structural and oxidative diversity present in the family. In addition to structural variety, these compounds demonstrate myriad biological activities. Many C-seco limonoids have been found to possess potent antifeedant, anti-cancer, and antimetastatic activity. As such, significant effort has been dedicated to advancing these natural products as potential therapeutics.