cleavage to produce hydrogen. The mobile robot (Figure ) acted as a substitute of a human experimenter by executing tasks and linking eight separate experimental stations, including solid and liquid dispensing, sonication, several characterization equipment and stations for consumables and sample storage. Remarkably, through a tedious ten-dimensional parameter search spanning 8 days, the robot achieved an impressive hydrogen evolution rate of approximately 21.05 µmol h -1 . Despite the initial investment and two-year development timeline, the versatility of this robotic system promises remarkable applications in materials, polymers, and chemical synthesis. Most automated synthesis platforms are based on expensive scientific equipment, require a large footprint and require extensive reconfiguration to adapt to new synthetic protocols. To address this issues Manzano et al. have developed a small-footprint portable chemical synthesis platform able to perform liquid and solid phase organic reactions (Figure ). The platform utilizes 3D-printed reactors that can be generated on-demand depending the targeted reaction, and features liquid handling, stirring, heating, and cooling modules for enhanced versatility. In addition, the platform is capable of performing inert and low-pressure atmospheres, separation steps, and pressure sensing for reaction monitoring. Its efficacy and robustness was affirmed through the successful synthesis of five small organic molecules, four oligopeptides, and four oligonucleotides, yielding high purities and impressive yields. Although, in the current configuration the platform lacks characterization modules and has lower throughputs in comparison to other automated platforms, it does offer a low-cost alternative that can be adapted to perform chemical reaction optimization.