Within the exposomics community the concept of exploration of the chemical space has been focused on building large chemical databases (e.g. PubChem). Additionally, recent works have used text mining approaches to further enrich these lists and thus expand the known chemical space. These tools have also enabled the classification of chemicals based on their functional groups or repeating units. The ultimate goal of these efforts has been the detailed characterization of the exposome chemical space. However, they are inherently limited to the registered and/or identified chemicals.