As a representative example, the binding of m-1 to bromide was also investigated in other solvents (Table , entries 3-6). Acetonitrile, dichloromethane and an acetone/chloroform mixture led to a reduction of about 2 kcal/mol in binding strength, and approximately the same difference was gained when changing to toluene (with the association strength now exceeding 10 kcal/mol). This is generally in line with less polar solvents leading to stronger interactions, but (as previously observed in other cases ) it is not clear why THF is a comparably good and DCM a rather bad solvent. In accord with previous titrations by our group, the entropic contributions typically play a minor role for the overall Gibbs free energies of binding with neutral halogen bonding systems.