We experimented with 32-replica systems for both Vendi sampling and Replica sampling, initializing all replicas in the β-stranded state. We find that the Vendi sampler effectively used the Vendi force to break the hydrogen bonds between the amide nitrogen and carbonyl oxygen atoms stabilizing the β-stranded states, resulting in several replicas transitioning to the left-handed state within the first 1.0 ns (Fig. &). In contrast, the Replica sampler relies on thermal fluctuations to cross this free energy barrier. Replica sampling, further requires an approximate three-fold larger simulation effort to equilibrate the average relative state populations within the accuracy of the baseline estimate. This demonstrates Vendi sampling's enhanced capacity for climbing the large energy barrier and discovering the left-handed minima quickly. The increased mode coverage during the early stages of the simulation facilitated faster convergence to the true free energy difference, as illustrated in Figure . It also important that our sampler encourages mixing across modes in the MD trajectories. We observe that while the Vendi force is applied over the first 15 ps of the simulation, the Vendi Sampler provides much better mixing in the MD simulation (Fig. ,B&C). The Replica sampler would mostly transition to the left-handed state later in the simulation (Fig. ,E,&F), by which time the Vendi sampler had already converged. We observe that the Vendi sampling average across trials converges within one standard deviation of the estimated true free energy difference in 15 ns less than the replica sampler (Fig ). We see from the marginal free energy show in Fig and the reference free energy surface in Fig Supp . S2A that the Vendi sampler is fitting the Chignolin folded state probability better.