• Remark. When treating the topological completeness as a specific motif type (i.e., a "null" type), the topological completeness prediction and the motif prediction can be solved jointly as a |X |classification problem. However, this naïve strategy suffers from a severe data imbalance issue -the number of "null" types in the data is much larger than the other motif types, which does harm to the model performance. Therefore, we treat them as two motiflevel prediction tasks in our model.