This study introduces an automated "unbinding kinetics" protocol that determines absolute residence time with minimal user intervention by utilizing RAMD and iMetaD. The workflow only requires a properly prepared structure of a protein-ligand complex and, in the case of membrane-bound proteins, a suitable thermalization protocol. The developed protocol is able to achieve 1.22 RMSE in log10(τ) on our set of 29 compounds spanning 10 orders of magnitude in residence time. Additional physically-motivated parameter tuning improved the accuracy up to 1.08 RMSE.