Overall, considering the synthesis, stability, and deprotection, SES and oNB-R proved to be the most useful SPGs (Table ). SES was the most stable across all conditions tested and could be synthesized from the aryl bromide via copper coupling or nickel dual photocatalysis. SES was amenable to most sulfinate coupling chemistry, further demonstrating its utility. SES, however, had harsher deprotection conditions with TBAF at elevated temperatures. oNB-R on the other hand, had stability across most conditions and had extremely mild and orthogonal deprotection conditions. PMB-R was a useful SPG in basic conditions but showed instability under harsher conditions. PMB-R, however, has a selective and unique deprotection method. SMOPS, the most common SPG used, had limited stability across numerous reaction conditions. It also cannot