Many environmental contaminants, such as dichlorodiphenyl trichloroethane (DDT), hexachlorobenzene (HCB), dieldrin (HEOD), and polychlorinated biphenyls (PCBs), generated by industrial activities, pass through food chains, posing a risk of exposure to the general population . Chemicals with both a high lipophilicity and a high environmental persistency should be thoroughly studied for potential toxicity via bioconcentration and bioaccumulation, both of which should be assessed over lengthy durations of exposure. The bioconcentration and bioaccumulation of chemical compounds in aquatic and terrestrial organisms are significant criteria for ecotoxicological evaluation and hazard assessment . The few studies using QSAR methods also focused on the development of models to determine the BCF specifically for compounds containing a chlorine atom or atoms in their structure. The models developed were based on different quantitative super-structure/activity relationships (QSSAR) . These models have the potential to be valuable in forecasting the bioaccumulation capacity of novel compounds, a crucial aspect in evaluating their ecological implications. The limited number of studies that have explored the inclusion of compounds with chlorine atoms in their structure necessitates further research to enhance the precision and credibility of these models for a broader spectrum of chemical structures. This constitutes a significant objective of the analysis expounded in this paper.