2. Finding analogue routes to support new synthesis ideas, as shown in Fig. . In this example, we wanted to know if it was possible to link the alpha carbon of aldehyde group to the adjacent amine group. The single-step analogue route was found. Although it was not an intra-molecular reaction, the reaction information could be still useful, since the identified chemical transformation shared the same substructure with the target transformation. is able to find reported asymmetric reactions that lead to a target chiral substructure, instead of a specific chiral molecule. This approximate search approach improves the exploration rate of reaction data, since the number of asymmetric synthesis records of a specific chiral molecule are limited in many cases. To initiate the search, a user needs to provide a target chiral substructure cut from a chiral molecule to be synthesized. As shown in Fig. , specification of a chiral substructure is conducted by selecting atoms expanding from a chiral center. Selected chiral substructures can be of any size, as long as they afford chiral centre (i.e., at least a chiral centre surrounded by four atoms). Users can include molecular segments that are considered important or unique for asymmetric synthesis. Like "search analogue routes", relevance and number of results are determined by the chiral substructure and heuristics listed in Table . Reaction conditions and asymmetric catalysts of analogue reactions are helpful for design of new asymmetric reactions for experimental validations. Aiming to find synthetic routes to S-Zanubrutinib that would compare favourably to the patented route shown in Fig. , a long-range search (12-steps) was conducted first. Several interesting routes were found but not many feedstocks were in the class of 'renewable' molecules. Hence, a long-range search from renewable molecules to feedstocks found in the first round was performed. After examining these longrange routes, we wanted to shorten the synthesis length, improve yields, and avoid hazardous reagents, solvents, and intermediates. Searchers of analogue routes and chiral reactions were conducted for this purpose. Inspired by analogue routes and chiral reactions, we proposed new routes and reactions together with new intermediates. A few more searches were run to support the new design. Finally, we obtained a shorter, safer, greener route composed of the reported and newly designed reactions. The proposed route was then verified in the iDMT lab.