The final attempt at determining possible combinations would be to look for combinations that are only connected by interaction information from WikiPathways but without regard to pathway boundaries (Figure ). The idea of this last approach was to find new potential combinations by extending the network with connections to other pathways that are not associated with the gene products or proteins that are the identified targets. This type of expansion, however, is likely to be much too far removed from the biological explanation using the mathematical model. This did turn up a far greater number of predictions at 7545 synergistic predictions, with 2223 edges and 315 nodes. This means that the network becomes more and more connected the further the network is expanded. If extended too far, then the entire WikiPathways graph will connect all pathways and nodes to each other and almost every combination of drug targets is possible.