The parameters discussed so far (surface charge, entrapment efficiency, etc.) relate mainly to the performance and behaviour of drug delivery systems under in vivo and in vitro conditions. However, those discussed later in this section relate more to the structural composition of the nanoparticles (e.g., the presence of functional groups, the lipid layer around the polymer core, etc.). This, of course, should be interpreted as the internal composition has nothing to do with the fate of the nanocarriers. On the contrary, the effect of coating a lipid shell around the polymer core is the main reason why CSHNs were discovered in the first place.