The quinazolinone ring systems are attractive fused heterocyclic scaffolds as they are structural cores of many alkaloids and pharmaceuticals with wide range of important biological activities. Most of the natural products and active molecules with a quinazolinone backbone exhibited a wide range of pharmacological activities such as antibacterial , antimalarial , anti-inflammatory , anticonvulsant , antidiabetic and biological functions such as cytosolic phosphorylation inhibitors , ligands for benzodiazepines and GABA receptors in the central nervous system , DNA binding agents . The appealing architecture and significant biological activities of these quinazolinones have received remarkable attention in the synthetic community and many useful synthetic routes and strategies have been developed for the generation of highly functionalized quinazolinones. Among these quinazolinones, N-aminoalkyl quinazolinone serves as important components of various pharmaceutically important compounds (Figure ). For instance, Pegaharmalines A is a bio-active alkaloid bearing a N-aminoalkyl quinazolinone skeleton, which exhibited significant antitumor activities . Compounds containing N-aminoalkyl quinazolinone C shown potent sedative-hypnotic and central nervous system depressant activities . However, methodologies on effective construction of N-aminoalkyl quinazolinone has been much less accessed, and novel and efficient protocol for effective synthesis of N-aminoalkyl quinazolinones are in high demand. Regarding the importance of N-aminoalkyl quinazolinones, we aimed for a novel and simple strategy to construct highly functionalized N-aminoalkyl quinazolinone compounds with high chem-and regio-selectivity. Notably, Minisci type of reactions have emerged as powerful and efficient methods for providing direct access to the functionalized quinazolinones for the recent years, and this strategy was mainly focused on direct C2-H functionalization of quinazolinones. In 2021, Phipps and coworkers reported an asymmetric aminoalkylation reaction of quinolines through Minisci reaction pathway using simple alkylamides as the aminoalkylation reagents under oxidative reaction conditions. We envisioned a visible-light promoted direct coupling reaction of quinazolinones with simple alkylamides under an oxidative reaction conditions to approach highly functionalized N-aminoalkyl quinazolinone products. Herein, we disclose a novel protocol for highly effective and direct construction of N-aminoalkyl quinazolinone derivatives employing tert-Butyl peroxybenzoate (TBPB) as oxidant in combination with visible-light irradiation condition. (Scheme 1).