Overall, the results from the sensitivity analysis highlight the influence of assumptions on the financial and environmental sustainability of the POU technologies. The identification of key drivers can also guide technology developers in areas to focus on for research and improvement. For instance, when deploying POU chlorination using WaterGuard or similar products as a source of NaClO, then the desired dose of NaClO will be an important factor to consider while adjusting for cost and environmental impacts. The cost of the AgNP CWF is primarily impacted by labor to manufacture the filters, suggesting that exploring mass production methods may further reduce costs. Lowering the unit cost is a key area for improving the cost of both UV systems. The negative Spearman's rank correlation of GWP impact of lamp and LED lifespan on GWP indicates that enhancing lifespan can increase environmental sustainability. These key drivers can provide a potential pathway for technology developers and manufacturers to improve the sustainability of these POU technologies.