The proteins examined include Sirtuin1 (PDB: 4ZZI), Mammalian target of rapamycin (PDB: 3FAP), Activated mammalian protein kinase (PDB: 5EZV), Klotho (PDB: 5W21), Mitogenactivated protein kinase (PDB: 1KV2), and Aryl hydrocarbon receptor (PDB: 5NJ8). These proteins' cellular localization (mainly in the nucleus and cytoplasm) influences their interactions with vitamin D, which affects their role in aging pathways. Understanding these interactions is crucial for elucidating how these proteins contribute to vitamin D homeostasis and its biological effects across key pathways related to cellular repair, metabolism, and stress responses. The in-silico approach aims to provide precise atomistic details of vitamin D's interaction and aging proteins. Molecular dynamics and electronic structure calculations complement this by predicting the solvation-free energy of vitamin D in water and a range of polar protic, polar aprotic, and non-polar organic solvents to characterize the interactions of vitamin D in bulk aqueous solution compared to an inbound state.