such as nucleosides, nucleoside monophosphates, and nucleoside diphosphates, these reagents are able to add three phosphate units to form nucleoside triphosphates, tetraphosphates, and pentaphosphates, respectively. Our group has sought to further expand this methodology of well defined, isolable oligophosphorylation reagents to introduce a varying number of phosphate units in one transformation. To that end, we have reported a tetraphosphorylation reagent and its utility to synthesize nucleoside tetra-and pentaphosphates. Here we further develop this strategy by reporting a potent diphosphorylation reagent and subsequent synthesis of NTP derivatives, a dinucleoside tetraphosphate, and a nucleoside pentaphosphate.