The carrageenan-induced paw edema in rats was used as a model to investigate the in vivo anti-inflammatory activity of mangiferin and benzoyl mangiferin (1) had considerable efficacy at a dose of 20 mg/kg for measures ranging from 30 to 360 minutes in rats with paw edema generated by carrageenan, as compared to the control group. Table . demonstrated a significant reduction in paw edema after 120, 180, and 360 minutes for mangiferin, benzoyl mangiferin (1), and acetyl mangiferin (3) at 10 mg/kg and 20 mg/kg, respectively. Nevertheless, compared to the tested samples, the normal dose of diclofenac (20 mg/kg) likewise yielded comparable and superior outcomes. After 360 minutes of tests, the percent protection was discovered to be 28.17 to 37.09.