Telomere repeat-binding factor dimerisation (IPR013867) undergoes dimerization. Telomeres are responsible for safeguarding the extremities of chromosomes from degradation and end-to-end fusion, as well as preventing the activation of the DNA damage checkpoint. Among vertebrates' telomeres, telomeric repeat binding factor (TRF) proteins TRF1 and TRF2 are the most important parts that keep them stable. Two related human TRF proteins, hTRF1 and hTRF2, form homodimers and directly bind to telomeric TTAGGG repeats via the myb DNA binding domain at the carboxyl terminus (IPR001005). Telomere length regulation is a function of TRF1, while telomere protection is a function of TRF2.