while an IDAC calculation also involves a transfer between environments, it is a transfer between two condensed phases, which usually is associated to a much smaller change in polarization of the solute molecule in comparison to transfer from the gas phase, as in the case of hydration free energies. IDAC values thus could potentially be an even better way to test how a force field represents a condensed-phase environment than hydration free energies, and potentially a better source of parameterization data.