Generation of children by DW-BEL co-evolution and their affinity ranking by ADV blind-docking have been combined here to unrevealed new ORF8 ligands. This automatic generation by co-evolution rather than by selection among databank compounds, was preferred to predict new molecules with some possibilities to inhibit the interferences of ORF8 SARS-COV-2 protein to the human immune response. Results successfully identified some of the ORF8 docking cavities and predict some novel putative scaffolds with many ligand variations.