Electronic and other weak bonding factors strengthen interaction forces by introducing multiple hydrogen bonds, covalent binding, additional van der Waals forces, or multivalent binding. Here we focus on the antiviral strategy of interfering with interactions involving host-guest sites to enhance the protective immune response against Sars-Cov2. However, although drugs targeting host proteins may be potentially cytotoxic or impact the human immune system, their appeal cannot be ignored . Implementation of this medicinal chemistry strategy is expected to pave a direct way to discovering new drugs effective against current and future threats due to emerging and re-emerging viral pandemics.