Additionally, recent studies on non-fullerene acceptors show the lone pairs on the nitrogens in unit 539 can delocalize to further reduce the bandgap . The solvation ratio top monomers interestingly tend to contain sulfonyl groups, which are highly polar and hydrophilic. We also determined the most commonly used sequences in the top 10% by fitness for each property search (ESI Figure ). Although we did not find obvious trends in the top sequences for either optical bandgap or solvation ratio, the top polarizability sequences were all near-homopolymers and occurred with incredibly similar rates of incidence. This supports previous findings in our group that homopolymeric sequences tend to increase overall molecular polarizability (near homopolymer sequences occur often simply because they are statistically more likely to occur and have extremely similar actual polarizabilities compared to true homopolymers). While a more in-depth analysis of the chemical motifs found in our realistic GA trial is beyond the scope of this work, our preliminary findings support the utility of implementing our GA best practices when conducting searches for a range of different optimized chemical properties.