In the cell, miRNAs bind to the 3'-untranslated region of mRNAs and target them for degradation by the RISCs. Because a single miRNA binds to multiple mRNAs, miRNAs serve as regulatory check points. The cellular processes regulated by miRNAs include those involved in many diseases, such as cardiovascular disease, cancer, and disease-related metabolic pathways. 106, 107 Thus, they can serve as biomarkers for disease diagnosis, as potential drugs, or as attractive targets for other regulatory RNAs.