For Garcia TMAO ff, the order is ΔGcavity (w)<ΔGcavity (w-ta)<ΔGcavity (w-ua)<ΔGcavity (w-ua-ta) whereas the order is following for NetzΔGcavity (w)<ΔGcavity (w-ta)~ ΔGcavity (w-ua)<ΔGcavity (w-uata). Independent of the force field employed, the cavity generation is toughest in urea-TMAO solution and is easiest in pure water. Depending on the chosen model for TMAO molecule, the cavity formation in urea solution is more difficult or equally difficult relative to that in TMAO solution.