The present work focuses on the synthesis and stabilization of both cobalt-rich (FeCo2O4) and iron-rich (CoFe2O4) spinel over support material. We have employed a combined state-of-the-art theoretical and experimental approach to achieve a fundamental understanding to design potential catalysts. The complex metal oxide nanoparticles supported over SiO2 grown on SiC and mesoporous silica result in a highly active and stable catalyst. To the best of our knowledge, this is the first attempt to examine the catalytic activity of both cobalt-rich (FeCo2O4) and iron-rich (CoFe2O4) spinels for this reaction. Hence, the present study enables us to design a highly active and stable catalyst for high-temperature reactions.