The University of British Columbia, Massachusetts General Hospital, the University of California, and the University of Cambridge have the largest number of published articles in scientific journals (Figure ). Patenting activity is dominated by corporate players as compared to academics (Figure ). F. Hoffmann-La Roche, AstraZeneca, Pfizer, and Vertex Pharmaceuticals have the highest number of patent applications among the companies (Figure ), while the University of California, General Hospital Corporation, and Harvard College lead among the non-commercial organizations (Figure ). More than a half of the documents related to polyQ diseases in the CAS Content Collection are associated with Huntington's disease, followed by SCA3, SCA1, and SBMA (Figure ), which roughly correlates with the worldwide prevalence of these diseases (Table ). With respect to the substance classes, the largest part belongs to the organic & inorganic small molecules (Figure ). We further explored distribution of the various polyQ disease-related concepts in the published documents (journals and patents) (Figure ).