This trend aligns with the broader success of therapeutic peptides, where most approved drugs are derivatives of endogenous hormones or other natural peptides, obtained by targeted modification approaches . As illustrated in Figure , nature offers a rich repository of active compounds. Detailed characterization of their mechanisms of action enables the rational optimization of their properties, transforming them into effective therapeutic agents. This approach mirrors the successful "sharpening" of natural compounds into novel drugs, highlighting the potential of AMPs as a robust tool against the growing threat of antibiotic resistance. Here, further advancements in experimental observation technology will bring advancements, since they will lead to a close-up of experiments and simulations, resulting in more sensitive and reliable data and predictions.