The disruption of chemical species transport and reactions can significantly contribute to the pathogenesis of endocrine diseases. For instance, impaired rates of insulin transport into tissues where it is needed or faulty insulin receptors can lead to type 2 diabetes mellitus (T2DM), characterized by hyperglycemia and insulin resistance . Similarly, altered bulk flow due to vascular complications can exacerbate conditions like hypothyroidism and Cushing's syndrome by disrupting hormone delivery and clearance . In diabetes, the impaired transport and function of insulin disrupt glucose homeostasis, leading to metabolic (biochemical) and biomechanical instabilities. These disruptions can manifest as tissue damage, neuropathy, retinopathy, and cardiovascular complications, further compromising the endocrine system's stability .