The bulk synthesis protocol relies on conversion of aniline to a diazonium intermediate followed by azo coupling involving the conjugate base of β-naphthol, Figure . The incompatible nature of reaction conditions for these transformations -acidic, followed by basic -necessitates two distinct reaction steps. Translating the bulk mixing steps to aerosol release instructions initially results in the sequence in Figure , where the addition of each reagent is abstractly represented as release events on a dedicated timeline.