The PDB molecular file format is the standard format for storing chemical topologies in most polymer and biopolymer research communities. However, loading a file from PDB presents a challenge to parameter-typed, direct chemical perception force fields, as PDB files only pro-6 vide atom elements, coordinates, and connectivity, and lack complete chemical information and charges. As pictured in Figure , overcoming this limitation for large molecules involves fundamentally different loading steps when compared to small molecules. Figure A typical workflow for simulating small molecules (blue arrows) which can be accomplished by existing bond order guessing and partial charging tools, as well as the formalized typical workflow for large molecules (red arrows) that uses template-based approaches.