Figure shows the highest scoring pose of 48:32 to Mpro, the molecular diagram, and the docking to Mpro and CYP 3A4. In CCDC GOLD, the sidechains of some of the amino acids in the cavity are allowed to rotate to some extent. In Figure an overlay of docked Nirmatrelvir to Mpro is shown with the protein from the docked 48:32 to Mpro. There is a small difference in the protein surface if the image is shown with the background protein of docked 48:32 to Mpro, but it is negligible. Figure shows the superimposition of both in the CYP 3A4 enzyme cavity. Molecule 48:32 has an almost Z2 or symmetry which is inherited from the same in the X-shaped cavity of the Mpro binding site. Were it not for an additional =O on one side it would be atomically reflective. This is in contrast to Nirmatrelvir which fills the legs of the cavity differently. The Ligand GA molecular evolution in finding optimal binders is guided by higher scoring molecules than the input population.