The non-filtered data (yellow, Form I; red Form II) reveals an increase in the presence of larger crystallites in the center of the tablet, those for Form I start to appear at 211 MPa reaching a maximum at 283 MPa before diminishing at 440 MPa. This indicates that at higher compaction pressures the original powder particles are annealing together to form larger particles when subjected to compression. Glycolide is a van der Waals solid which may facilitate this process due to the weaker, more malleable intermolecular interactions. This phenomenon is similar to the behavior observed in other van der Waals solids like benzene when solidified under pressure. Particle agglomeration, dominated by solid bridge formation, has also been reported during the compression of micronized small-molecule APIs like furosemide and griseofulvin blended with excipients. Although the author did not discuss the single-crystal-like nature of the agglomerates, Potharaju noted that the agglomerate size increased steadily with increasing compression force, paralleling the observed trend for glycolide Form I.