T013: Data acquisition from PubChem. PubChem is a database holding chemical information for over 100 million compounds. We demonstrate how to fetch data from PubChem's PUG-REST API , given the name or SMILES of a query ligand. For example, we show how to fetch molecular properties for a ligand of interest by name (aspirin) and how to query PubChem for the most similar compounds given a query SMILES (gefitinib).