In Table , we list the compute cost for each step of the polymorph prediction workflow for a representative set of molecules with increasing complexity. Our CSP workflow is significantly more computationally efficient than CPU costs reported previously by other approaches. To facilitate comparisons, we convert our GPU costs to CPU costs using a 1:10 conversion. For PF-998245, our CPU cost is 22.6K hours, whereas approximately 200K hours was reported in Ref . For rotigotine, our CPU cost is 26.5K hours whereas 125K CPU hours was reported in Ref . For XXXI, our computational cost is 93K CPU hours and 200 GPU hours, whereas most participants in the seventh blind test who successfully predicted the experimental structures used significantly more CPU hours. It should be noted that our calculations were limited to Z'=1 structure predictions, whereas these participants might have spent a lot of effort for higher Z' structure predictions, so these CPU hours might not be directly comparable.