Characteristic protons from Gem (see peaks m, n and o in Figure ) were clearly visible on the 1 H-NMR spectrum, resulting in a drug loading of 2.7 wt %. Similar rROPISA experiments were carried out in the presence of BMDO (f BMDO,0 = 0.66), with f GemMA,0 = 0.033 (G2) and 0.067 (G3). It produced the expected structures, as assessed by 1 H-NMR (Figure ), with ~10-12 mol % BMDO units inserted and drug loadings of 3.1 vs.10 wt %, respectively. In terms of degradation of the nanoparticle dry extracts, while G1 resulted in no decrease in M n after degradation under accelerated conditions due to the absence of BMDO, G2 and G3 showed a clear shift in SEC traces towards lower M n values, representing a -56 and -68 % decrease in M n , respectively (Figure ).