In addition, the SterimolC1-R Bmin term is directly correlated with enantioselectivity, which highlights the importance of substrates bearing bulky substituents near the cyclohexane ring to increase the interactions with the chiral catalyst pocket. Overall, this predictive model explains well the role of the bulky amide substituents and the reduced enantioselectivities obtained when using smaller and/or stronger electron-withdrawing substituents.