The "seven pillars" of oxidation catalysis indicate the several factors contributing to reactivity in oxidation reactions: 1. lattice oxygen, 2. metal-oxygen bond strength, 3. host structure, 4. redox properties, 5. multifunctionality of active sites, 6. site isolation, and 7. phase cooperation. 18, 19 In the case of vanadiumbased oxide catalysts, selectivity has been also related to surface enrichment of one of the metal ions in the presence of reaction feed containing steam and the associated surface potential barrier, 20, 23, 24 highlighting that the catalyst dynamics also plays a role. Due to the multiple requirements and the intricacy of the underlying processes, the theoretical description of selective oxidation and the search for new catalysts is extremely challenging. Alternative approaches for modeling and designing new catalysts are thus required. Here, we propose a combination of standardized experiments and AI to address this problem.