Recent reports showed that the outer lipid membrane of liposomes templates the formation of AuNPs-vesicle adducts and the extent of AuNPs aggregation, the compactness of the aggregate, and the colloidal stability of the outcoming hybrids can be finely controlled by varying the vesicle concentration and composition. The vesicle bilayer induces the formation of AuNPs-vesicle adducts, offering precise control over AuNPs-vesicle aggregate formation, compactness, and colloidal stability through modulation of vesicle composition and concentration. The formation of such AuNPs-vesicle hybrids combines the biocompatibility and encapsulation capabilities of lipid scaffolds with the diverse properties of inorganic NPs, such as electric, optical, magnetic, and catalytic functionalities. In addition, this synthesis method alows the introduction of targeting functionalities by conjugating antibodies to the liposomal surface through covalent and non-covalent interactions, resulting in multifunctional nanomaterials with potential simultaneous applications in diagnostics, imaging, and immunotherapy.