An analytical technique capable of being deployed in a point-of-care format at the patient's bedside could address the logistical challenges of using HPLC. Thin layer chromatography (TLC) is an interesting alternative approach that has been used for drug quantification for many years. It can be performed without the complex fluid flow systems of HPLC and has been shown to achieve comparable results to HPLC down to nM concentrations by scrapping the separated bands of drug off the TLC plate for subsequent quantification by solution-based fluorimetry. Advances in imaging technology have now made it possible to quantify the DOX bands directly on TLC plates through image analysis of the fluorescent bands via consumer smartphones and other devices. Despite its simplicity, and ability to be partially automated for high throughput applications , the TLC process has never been adapted for use in a bedside clinical setting due to the required organic solvents used in developing the plate and the hazardous silica dust material on the plate itself. Currently, the TLC technique is only performed in laboratories with ventilated fume hoods with quantification requiring additional expertise in chemical processing.