This is not surprising because we do encode the sequence in an abstracted manner in the physicochemical KiSSim fingerprint bits. However, some kinases show deviating relationships, of which some can be rationalized such as the CaMKK2 and DRAK2 relationship shown also in profiling data. Thus, the addition of structural information in the KiSSim fingerprint allows us to cluster more distantly related kinases. This aspect of the KiSSim tree is of interest because it predicts novel information on kinase similarities.