Finally, numerical parameters like tight SCF convergence or tight PNO thresholds yield limited accuracy gains relative to their computational expense. Tighter SCF settings generally incur only a small increase in run time, whereas tighter PNO thresholds can significantly prolong calculations. Consequently, we recommend normal PNO settings and either normal or tight SCF for most DLPNO-CCSD(T)-F12d calculations. While F12 corrections generally add over 50% to the run time compared to non-F12 variants, the resulting accuracy benefits typically warrant the extra cost. Without F12, DLPNO methods tend to struggle with ions, though they remain adequate for neutral molecules if at least a triple-zeta basis set is used (see Supporting Information).