The "Quantum Interacting Dimer" (QUID) benchmarking framework was developed here to redefine the state of the art in QM-based modeling of ligand-pocket motifs. Currently, QUID contains 170 structurally and chemically diverse large molecular dimers (42 equilibrium and 128 non-equilibrium) of up to 64 atoms, including the H, N, C, O, F, P, S, and Cl chemical elements, encompassing most atom types of interest for drug discovery purposes. This diversity enables a single dimer to exhibit multiple types of steric effects and NCIs simultaneously, including, but not limited to, π-π stacking, hydrogen, and halogen bonds.