In order to demonstrate the utility and correctness of our GPU implementation of the MI and GC estimator, we repeat a previous study by Lange et al. , where GC estimates using MI were first applied to a set of biochemical systems. One of these systems was the B1 domain of Protein G. Lange et al. examined the correlated motions of protein G using both GC and the linear (Pearson) correlation, showing that linear correlation predicted a number of key relationships within protein G intramolecular motion, but that a GC description revealed all the same relationships and more. Their original results are replicated in this study and displayed in Figure .