The monkeypox virus infected humans in Basankusu, Democratic Republic of the Congo, in 1970. This patient represents the first documented case of human monkeypox in medical history . It was first detected outside of Africa during the 2003 outbreak of human monkeypox in the United States. The sequencing of MPXV isolates from the United States, West Africa, and Central Africa confirmed the existence of two MPXV clades . Human monkeypox virus disease is typically only found in Central and Western Africa until 2022. (or associated with international travel, or the importation of animals from these regions). Since January 1, 2022, 105 Member States in all six WHO regions have officially reported cases of monkeypox virus to WHO. WHO has received reports of 64,561 laboratory-confirmed and 3,154 suspected cases, including 26 deaths, as of 22 September 2022 ().