Instead, models obtained here with Representation 2 produce a more relevant modeling compromise, allowing to better approach all experimental objectives across phase states and producing improved phase transition temperatures with respect to the lipid models in Martini 3.0.0 4 (Fig. ). In particular, the automated search of bonded parameters for the versatile building blocks of Representation 2 highlights that reproducing in Martini simulations the tilt angle of lipid bilayers in the Lβ' phase is possible. This is not trivial, as to our knowledge only one example of such CG simulations exists, where bonded parameters were manually optimized initially with the goal of obtaining a relevant modeling of the tilted ripple phase (Pβ') for DPPC specifically, without considering the impact on the modeling of other lipid types (FF parameters are unavailable for this study). We envision that further working on the CG representation, potentially by slightly tweaking bead choices to further enhance the balance of bonded and non-bonded interactions in between lipid heads and tails, may allow to describe tails tilting in the Lβ' phase for relevant saturated lipids in the Martini framework.