By defining model reactions through fixed-depth condensed reaction graphs, we achieved mean absolute errors of approximately 5 kcal/mol in activation energy predictions across a diverse set of organic reactions. The development of four sampling schemes further showed how model reaction transition states can be leveraged to accelerate the discovery of transition states for larger molecular systems, with the most sophisticated scheme (SS-IV) achieving chemical accuracy even for complex stereochemical transformations and still reducing costs by ∼80% relative to direct TS localization.