Herein we report the detailed analysis and further investigation of the antifungal metal complexes screened within CO-ADD. From the large number of active and non-toxic metal complexes identified in our library, the most active ones were tested against an extended panel of relevant fungal strains. A selection of compounds with the best activity profile were then evaluated for toxicity in the in vivo insect model G. mellonella. We showed that most compounds had no toxic effect in this model at the tested concentrations. Finally, two non-toxic antifungal metal compounds were further studied in an in vivo G. mellonella efficacy (infection model) assay.