The SA Synthesizable-Wrong fragments D, E, and F in fig. for which SA Score wrongly predicts molecule as synthesizable, have distinctly different influential features from SA Unsynthesizable-Wrong fragments A, B, and C. The SA Synthesizable-Wrong fragments have features which SA Score either underestimates destabilizing effects or overestimates stabilizing effects. Surprisingly, the aziridine group (fragment F) appears in a significant 34% of SA Synthesizable-Wrong molecules. Aziridines, hetero cyclic and cyclopropane compounds with one nitrogen atom, are important intermediates in organic chemistry due to the synthetic routes enabled by their ring-opening reactions. The aziridine fragment isolated here, however, corresponds specifically to N-substituted aziridines, which are more difficult to synthesize because most of their azirdination pathways require high-energy precursors serving as both the oxidant and nitrogen source. While E min has no knowledge of the aziridination pathways, its ability to correctly predict synthesizability may be due to ring-strain and in determining if the N-substituents are sufficiently electron-withdrawing. The isoaxozole (fragment E) and furazan (the 5-membered ring in molecule D1) parents in fig. are synthesizable, as are many of their derivatives. Unlike SA Score, E min can tell when substituents reduce a ring's aromaticity, which is a well studied phenomenon; 47 this phenomenon is relevant for molecules D1, E1, and E2.