From a synthetic standpoint, a systematic exploration of the coordination chemistry of any chosen HnTBC[n] should carefully examine the role of solvothermal conditions in the clusters that result from this chemistry. This synthetic approach clearly has the capability to deliver fascinating new species, but achieving a far greater understanding of the influence of these conditions over the calixarene (cluster support) and components that are found in the products will be vital to a) compiling a set of binding rules for any particular HnTBC[n], and b) tailoring the formation of desirable assemblies.