Aryl sulfonyl fluorides can also be obtained from the corresponding sulfonic acid, sulfonamide, sulfonyl chloride, or thiol. Sulfinate protecting groups (SPGs) represent a promising approach to overcome the limitations associated SF synthetic instability (Figure ). The protected sulfinate can be carried through the necessary synthetic transformations and then subsequently deprotected. This would allow for not only greater structural diversity, but also permit a more combinatorial approach to developing varied SF-containing structures.