The drawbacks of all techniques are that (1) the compound needs to be synthesized in a substantial amount, (2) different equipment needs to be available, and (3) the determination of solubility in different solvents needs a lot of expertise and time. The ability to predict solubility accurately could offer a lot of benefits to the current process of manually determining the solubility of new compounds. First of all, the laborious and time as well as resource-consuming measurements could be replaced by suitable predictions (at least in parts), and secondly, predictions could help to design potentially interesting molecules -preventing the synthesis of compounds that do not obtain the expected properties.