Xenotransplantation in zebrafish embryos: Xenotransplantation experiment was performed as described previously. Briefly, MOLT-4 cells were labeled with Vybrant™ CFDA SE Cell Tracer Kit (Invitrogen) following the manufacturer's instructions, and then were suspended in PBS at a density of 1 × 10 8 cells/ml. Approximately 1 nl cell suspension (around 200 cells) was injected into the perivitelline space of embryos at 32 hpf. Injected embryos were first incubated at 28°C for one hour. Only embryos with good engraftment were selected for treatment with DMSO (control group), AUY922 (500 nM) or 5b (500 nM) for 48 hours at 35°C. This temperature enables the maintenance of embryos with grafted cells without compromising zebrafish development. Drug-treated embryos were dissociated by passing through a 40-µm cell strainer (Greiner Bio-One) and then analyzed using a BD LSR II flow cytometer. Fold change of engrafted MOLT4 cells was calculated to mean of DMSO-treated embryos. GraphPad Prism software (version 7) was used for graphing and statistical analysis.