Beyond the ease of setting up complex libraries, this would also allow further decreasing the reaction scale with maintained reproducibility, surpassing the limitations of solid dispensing methods. 2) Reactions tolerant of moisture, allowing for direct use of reagents and large compound libraries without the need of rigorous drying. 3) Reactions tolerant to air atmosphere. 4) Commercially available reagents. 5) Compatibility with plastic reaction vessels. 6) Compatibility with non-volatile reaction solvents. The last 2 points are crucial for miniaturization and use of 384-and 1536-well reaction plate formats.