dUCT-v2 is the most effective at solving a random molecule for all time constraints and iteration values, and dUCT-v1 is the most useful for finding routes to a molecule which is solvable, within a given time. For an exemplar target molecule, almotriptan, dUCT-v2 found more routes than UCT (Table ) and only dUCT-v2 found the two most sustainable routes. We conclude that our MCTS enhancements significantly improve the number of routes found per molecule, the computational clock-time to solve a molecule, and percentage of solved targets.