The 1,583 and 30 reaction barrier estimates for the systematic and meta-dynamics approach, respectively, take about 29 minutes and 2 minutes, respectively, on the same cluster. The final DFT refinement step involves 64 and 15 molecules for the systematic and meta-dynamics searches, respectively. However, this can be reduced to six DFT refinements by pre-screening using GFN1-xTB as described above, although in that case the new reaction is not discovered by the systematic approach. In conclusion, our best estimate is thus that the three lowest barrier-reactions can be identified for DFT refinement in about 18 minutes using the meta-dynamics approach and in about 35 minutes using the systematic approach on 100 cores.