An even more extensive scaffold network approach was published recently by named "Molecular Anatomy" . While the aforementioned approaches mostly rely on one single scaffold definition, respectively, nine different scaffold types of different abstraction levels were introduced here. All of them can be dissected analogously into parent scaffolds and linked in a network representation. This way, common substructure patterns can be identified on a higher abstraction level than with scaffold networks and more relevant similar compounds determined. This may be helpful for analysing HTS data or preparing structure activity relationship (SAR) studies of scaffolds and their side chains. However, this type of scaffold network including also more abstract scaffold representations has an even stronger tendency to grow very quickly with an increasing number of included structures and hence to quickly become unfathomable without sensibly limiting the display.