To demonstrate the applicability of the ACE framework to more complex reactions, we modelled the reaction between tropone and cyclohepatriene, R2, and monitored its product distribution. This reaction has been previously studied by Houk and co-workers using quasi-classical reaction dynamic simulations. The reaction has been found to involve an ambimodal TS that leads to three distinct products: one [8+2] and two [6+4] cycloadducts (Fig. , top).