Here, an integrated WATERGATE (iWG) pure shift experiment is introduced, and its performance is compared to that of previously published methods. The proposed pure shift iWG experiment enables retention of exchangeable proton signals, allows the use of short recovery delays for either fast data acquisition or acquisition of higher signal-to-noise ratio (SNR) spectra per unit time, and offers over a thousandfold reduction in solvent signal intensity. As the WATERGATE element is integrated into the pure shift experiment, no extra scalar coupling evolution occurs. The usefulness of the proposed method is demonstrated in the analysis of cyanocobalamin (manufactured vitamin B12), where WG enables exchangeable amide signals to be observed in the pure shift spectra, and atropine eye-drop solution (a pharmaceutical formulation), where the ultrahigh resolution afforded by the new solvent-suppressed pure shift method aids the identification and characterization of degradation impurities in the atropine formulation.