The entire sequence of tau protein contains mitochondria-related domains, as illustrated in Table . Tau protein is upregulated and ubiquitously expressed under microenvironmental stress, such as hypoxia or low glucose conditions, as indicated by the HIG1, Calcium uniporter protein C-terminal, and Mff-like domains. The mitochondrial calcium transport and calcium uptake pathways direct it to the mitochondria. The Tim10-like and Tim44-like domains, the mitochondrial outer membrane transport complex Sam37, and the clustered mitochondria protein N-terminal all point to the idea that tau protein gets into the mitochondrial interior through the inner membrane sorting apparatus and the outer membrane of the mitochondria. The DNA-directed DNA polymerase family B mitochondria domain evidences that the tau protein can inserttelomeric fragment sequencesinto the mitochondrial DNA genome .