Wide enough to include the previously proposed disulfide target , the erizo and the erizo's targeted cavity were uploaded to DW-BEL. Co-evolutions rapidly began trimming, changing, adding and selecting the erizo's carbon atoms to generate thousands of children best fitting to any docking cavity located nearby those defined by the erizo (Figure , blue stars). Using this strategy, and thanks to the adaptability of the cavity during co-evolutions, two docking cavities were identified at the ORF8 asymmetric homodimer. The example described here in more detail, randomly generated 46822 raw-children (erizo's children) of which only 1409 were fitted-children (Figure , blue stars). One of the docking cavities was located at the AB interface (53 % of the fitted-children) while the other was located at its hypervariable A loop (Figure , down). Because the hypervariable A loop has been implicated in other protein-protein interactions, the AB ORF8 interface cavity was chosen for this first study. . The erizo's children targeting the AB interface cavity predicted maximal affinities ~ 100 nM (Figure , blue stars) and two main scaffolds. To explore for higher affinities, two top-children were selected (16153 and 46808), each representing one different scaffold (Figure , right 2D molecular geometries and Table , children).