We refer to situations when two or more methods produce the same prediction as ensemble predictions. Of the 19,074 test spectra in set 1, there were 18,734 for which ensembles of two or more of the predictions were in agreement. Of the 162 examples in test set 2, there were 118 ensemble predictions. Tables and summarize the results of the 32 ensemble scenarios that may arise for both the organic molecule and small molecule drug test sets, respectively. There are too few occurrences of many scenarios listed in Tables and to make general comments about algorithm performance. However, the results suggest that having equivalent predictions across multiple methods can be a powerful tool for an analyst. This is particularly true when all three predictions are the same, regardless of the classifier index values. When classifier values are greater than their corresponding thresholds and all three predictions are in agreement, the predicted molecular mass was correct, save a few instances where the labelling of the query spectrum itself can be brought into question (e.g., the analyte molecule may have degraded at the inlet).