The hydrodynamic diameter (Dh) of unloaded, CUR loaded and IBU loaded polymer micelles were analysed by DLS. Interesting to note in this context, as determined by pyrene assay, both A-pEtEtOx-A and A-pPrMeOx-A series polymers exhibit a rather high CMC (1.1-3.6 g/L, i.e. 1.2-4.1 × 10 -4 M), compared to their isomers A-pBuOx-A (8 mg/L, 1× 10 -6 M). The triblock copolymers were dissolved in PBS (polymer concentration 10 g/L) , filtered (0.45 µm) and measured by DLS at 25 °C. The DLS profiles of the micelles were bi-or multimodal with broad size distribution, indicating the formation of heterogeneous particle populations (Fig. ). Comparing the size distribution by intensity, volume and number (Fig. ), it becomes clear that for M A-pEtEtOx-A and M A-pPrMeOx-A mainly small self-assemblies (presumably micelles) of Dh ≈ 5 nm along with very few, much larger particles (apparent Dh ≤ 250 nm) are present.