We have addressed the thermodynamics of solid-liquid interface formation through extensive DFT-MD simulations and detailed entropy analyses within the 2PT formalism. Through this approach, we were able to several thermodynamic quantities, such as free energies, entropies, adhesion works, and surface tensions for a range of relevant metal-water interfaces (FCC(111) Pt, Pd, Au, Ag, Rh, and AuPd) for the first time to our knowledge. To understand the atomistic origins of these thermodynamic quantities, we have correlated them with both structural and energetic quantities.