The calculated binding energies of the top-scoring antiviral drugs, dolutegravir, cabotegravir, bictegravir, tipranavir and RSV-604 are similar (in the range of -38.8 to -42.2 kcal/mol by MMPBSA and -36.2 to -45.9 kcal/mol by thermodynamic cycle). Some of the highest-ranked antiviral agents had also been identified as good binders in other in silico docking studies, providing a degree of validation that our computational Although the main aim of this study was to show that our computational methods are useful for rapidly identifying repurposed drugs likely to exhibit SARS-CoV-2 activities, we have also analyzed the binding of key repurposed drugs (Table ) to the helicase active site. Figures show LigPlot diagrams of the main interactions between four of the drugs and the binding site. They elucidate how the drugs bind to the active site of the helicase enzyme. Supplementary Figure shows a superimposition of the drugs with the most favourable binding energies in the active site of the helicase.