Our group recently detected a putative mic BGC in the cyanobacterium Microcystis aeruginosa LEGE 91341 (NCBI: JADEXY000000000) encoding a dimetal carboxylate halogenase homolog (Fig. ). Here, we report the discovery of twelve new microginins (compounds 1-12, Fig. ) from this strain, including mono-and di-chlorinated, as well as non-halogenated congeners. The mic BGC from M. aeruginosa LEGE 91341 was heterologously expressed in E. coli using DiPaC, leading to the production of several of the microginins found in the cyanobacterium but also of new variants. Our work confirms that mic is the microginin BGC and opens the door for accessing novel microginin diversity, namely through the expression of additional variants of mic BGCs captured from (meta)genomic data or by engineering the mic pathway. Furthermore, this study reinforces the usefulness of the DiPaC strategy for cyanobacterial NRPS/PKS BGC deorphanization.