(c) Isotopic Composition: Isotopic substitution can occur naturally or artificially in chemical compounds, leading to variations in molecular mass and properties. Isotopic composition accounts for the presence of non-natural isotopes or abundances. This ensures that the resulting InChI accurately reflects the isotope profile of the molecule, enabling precise identification and characterization. The InChI technical document briefly explains how InChI manages isotopes. After the above mentioned steps, the subsequent canonicalization steps are undertaken to ensure the generation of a unique canonical representation.