In general, the complexity of various factors influencing the performance of photocatalysts modified with co-catalyst can be well exemplified on TiO2-based photocatalysts for light-driven aerobic oxidative degradation of organic pollutants. It has been suggested by Gerischer and Heller already more than thirty years ago and later confirmed by detailed mechanistic studies that the kinetics of photocatalytic oxidation of organic molecules at TiO2 particles is typically limited by the rate of oxygen reduction by photogenerated electrons which is significantly slower (by several orders of magnitude) than the oxidation of organic molecules by photogenerated holes. A faster consumption of photogenerated electrons by catalytically enhancing the rate of their reaction with dioxygen reduction is therefore expected to lead to diminished recombination and thus to process intensification, as has been demonstrated for TiO2 photocatalysts modified with Pt or CuOx and FeOx nanoparticles acting as co-catalyst for oxygen reduction. It is important to realize that any good co-catalyst for oxygen reduction should effectively extract electrons from TiO2 and enhance the surface catalysis, but, at the same time, it should not significantly block the light absorption by TiO2 and should not induce the formation of energetically deep interfacial trap states that would drastically diminish the reductive power of trapped electrons and act as recombination centers (Figure ). sites, we extend the concept to anatase TiO2 modified with Cu(II), Fe(III). In addition, we introduce, for the first time, anatase TiO2 modified with vanadate SACs, and showcase its superior photocatalytic performance with respect to benchmark state-of-the-art photocatalysts.