It is evident that there are a plethora of materials, metrics, and software tools to incorporate QC in the core laboratory. Still, there are much needed advancements on the horizon that will make this even easier by improving interoperability and universality of QC. For instance, as the mzQC standard is finalized and adopted (), it will become easier to compare, combine, and track QC metrics from different software tools into custom QC reports fit for the laboratory, study, or analysis, as well as deposit this information alongside experimental data. In terms of "universal" QC, a radical concept discussed in depth during a 2022 Lorentz Center Workshop on proteomics and machine learning 114 , is that one day researchers will be able to generate realistic synthetic data matching every sample, analytical procedure, and instrumentation in order to evaluate the quality of any dataset without commercial QC standards, making each sample its own QC sample. Such integrated models for synthetic data generation may still be a few years away from being implemented in core laboratories, but once they are, they will immediately provide a framework for computing a large number of informative QC metrics based on the analysis results. Until we reach this point, the availability of a wide range of QC materials across QC levels coupled with QC software should enable any proteomics mass spec core to generate QC metrics of their complete process, helping troubleshoot when needed, and lending confidence in delivered results.