Trichophyton mentagrophytes, Microsporum gypseum, and Microsporum canis are pathogenic dermatophyte strains that N. sativa extract has shown antifungal action against. In an in-vivo investigation, mice were infected with Candida albicans a pathogenic yeast present in the human gut microflora which was then treated with an aqueous extract of black seeds. The extract showed inhibiting activity towards fungal growth activity in them On performing a different treatment experiment for Candida-related infection with Nigella sativa extracts, the antifungal effect was assessed by measuring the zone of inhibition. These results indicated that the methanolic extracts of Nigella sativa had a strong antifungal effect followed by the chloroform extract and the aqueous extract showed no zone of inhibition. )