Using the sequential addition strategy, reactions that require different catalyst loadings for the first and second coupling can be performed by introducing additional equivalents of either catalyst after the completion of the initial coupling. Through this method, 1-iodo-3-phenylpropane and ethyl 4-bromobutyrate could be sequentially coupled with 1-bromo-4-iodo-2-methoxybenzene in 84% yield through the addition of 4 mol% bpy Ni after the initial coupling (Entry 3). Additionally, an unsubstituted bromo(iodo)arene, 1-bromo-4-iodobenzene, was coupled with benzyl chloride and ethyl 4-bromobenzoate in 70% yield through the addition of 5 mol% Co Pc after the initial coupling (Entry 4). Further, in some cases, it is possible to perform these transformations in a single-step, as demonstrated by the coupling of 1-bromo-4-iodo-2-methoxybenzene with benzyl chloride and 1-bromo-3-phenylpropane with high regioselectivity to generate the desired product in 76% yield (see Eq 1 and SI for further details), which extends the practicality of the method.