The inherently complicated conformational landscape of RNA includes a myriad of structural motifs such as pseudoknots, triple helices, multibranch loops, internal loops, bulges, and hairpins A mounting body of evidence suggests that conformational transformations in RNA structures are often required for normal cellular function . Dynamic RNAs, however, pose a unique challenge to current experimental techniques used in structural biology in characterization of atomistic details. The conformational landscape of RNA encodes unique structures, which give rise to a diverse RNA structural ensemble . In addition, interactions with macromolecules such as proteins and small molecules can perturb the native conformations and alter the overall structure . Indeed, conformational dynamics discovered within RNA hairpin structures have recently been shown to play an important role in downstream biology with lowpopulation states affecting biological outcomes . These ensembles offer both intriguing and unique targets for structure-based drug design . Collectively, these observations challenge the assumption that the global minimum conformation of the apo state is the primary target and suggest that conformations of local minima hold the key to improve selectivity while targeting RNA with small molecules .