Lipoplexes which are the other vesicle types for delivering condensed oligonucleotides can be composed of ionizable lipids to relieve the toxicity of vehicles and prevent inflammation due to positive charge and make a more efficient endosomal escape, as well. By adding special lipids, selective organ delivery could be also possible . Nonetheless, liposomes and polymeric nanoparticles encounter drawbacks such as instability, quick drug release, restricted drug loading capacity, poor biocompatibility, and unsuitability for large-scale manufacturing . In terms of nucleic acid delivery, the possibility of partial degradation of the drug after complexation with the cationic polymers, colloidal instability of lipoplexes and polyplexes in the extracellular compartment of the body, reticuloendothelial system (RES), extravasation, possible problems regarding biodistribution or organ and cellular targeting are among the challenges in designing a suitable delivery system . There are also some toxicologic concerns with current organic and inorganic medical nanoparticles .