The MSZW of these API solutions experimentally measured using the polythermal method was obtained from the literature. This method involves changing the temperature of the solution from a reference solubility temperature 𝑇 * at a predefined cooling rate and detecting the onset of nucleation at 𝑇 . The relationship between the reference solution temperature, temperature at which nucleation can be observed or detected is shown in Figure . In Figure , we also showed the line of supersolubility concentration, solubility concentration and their relationship with the MSZW, Tmax and the supersaturation at the MSZW, Cmax)