By formulating triplex origami design rules in terms of DNA geometry, the DNA sequence itself becomes arbitrary as long as it is sufficiently diverse. TFOs only recognize purines, however, and sequence diversity is less trivial with a two-base alphabet compared to a four-base one. Our scaffolds therefore encode polypurine regions spliced from custom DeBruijn sequences. Each 11-14 bp polypurine stretch embedded in these sequences is unique and follows several constrains which promote triplex formation over other, non-canonical secondary structures. This ensures two ease-of-use benefits. Firstly, one scaffold can be folded into myriad of different shapes (and vice versa). Secondly, none of these shapes requires staple sequence optimization.