These findings highlight the intricate relationship between PEG incorporation, the pivotal role of wettability and copolymer composition in enzymatic degradation, providing essential insights for tailored polymer design . The breakdown in weight averaged molecular mass is reflected in the morphological properties, as it will be further discussed in the subsequent SEM section, exploring the correlation between these molecular and morphological changes. and narrows the polydispersity index as showed in chromatograms in Figure . The balance between hydrophobicity and hydrophilicity in the polymer structure is crucial for facilitating enzymatic degradation using lipases . Lipases, distinguished by a hydrophobic binding domain and a catalytic active site, engage in heterogeneous enzymatic reactions which involve two pivotal steps: initial adsorption, where hydrophobic enzyme domains adhere to the polymer's solid substrates through hydrophobic interactions, followed by hydrolysis, where ester groups are enzymatically hydrolyzed at the catalytic domains .