Our consensus interpretation of this statement is that, at least for cyclic compounds and compounds with more than one stereocenter, a unique digraph must be generated for each center in question. This includes double-bond as well as axial stereochemistry and is true whether the center in question is in the ring or not. Temporary auxiliary descriptors are assigned solely on the basis of this digraph and may or may not be the "final" descriptors ultimately used to describe those centers using their own digraphs. Figure shows an example (VS279) where only a minority of the auxiliary descriptors are the same as the final descriptors for the corresponding atoms. Generation of a complete digraph, including all auxiliary descriptors, including seqcis and seqtrans, is required prior to Rule 3. The entire sequence of all rules must be carried out for each auxiliary center on the same digraph. Generation of auxiliary descriptors must start from the highest sphere, proceeding toward the root. In this way, all auxiliary descriptors in higher spheres than the one being determined are already assigned. This is sufficient, as the descriptor for an auxiliary center does not depend upon any descriptor between it and the root. The auxiliary center ligand leading to the digraph root can always be ranked by Rule 1a exclusively, as auxiliary centers are offset from the root of a digraph, and so the path back to the root is always unique in connectivity and atomic numbers.