The efficiency and robustness of the xTB methods are particularly appealing facets in the integrated approaches, where the chemical problem is addressed through the Divide and Conquer strategy. The core idea is to divide the molecular system into several regions or layers, each calculated at a certain level of theory and merged into a multiscale model. Such models usually target cases where conventional abinitio theories are not feasible. The one prominent example of the integrated model is the ONIOM (Our Own N-layered molecular Orbital and molecular Mechanics) method. The simple variant of the ONIOM method is a two-layered scheme: the system is partitioned into inner and outer regions. The inner region, usually of higher interest, is treated with a more accurate theory. The environment, or outer region, is accounted for by calculating the inner region and the entire molecule at a lower level of theory and then subtracting the former from the latter. It is crucial that, while the inner region can be treated with ab initio methods (assuming a reasonable cutoff size), the lowerlevel theory must also sufficiently describe the entire system to ensure sufficient accuracy. In this context, the use of xTB methods becomes particularly advantageous due to their broad parametrization.