Most of the services provided by the chem, convert, and depict modules can be accessed using SMILES as an input format for molecular structures. Where a specific functionality provided by the microservice can be achieved in a similar manner with RDKit, CDK, or Open Babel, the user has the option of employing the toolkit of their choice via an additional parameter. The chem module offers routines for structure manipulation and standardisation, descriptor calculation, and chemical classification. The standardize functionality is used via a POST method for the purpose of standardising molecules represented by MOL format tables through the ChEMBL structure curation pipeline. The convert module enables users to convert SMILES representations into other formats of their choice, using the GET method. Meanwhile, the depict module allows users to generate customised 2D depictions of molecular structures, offering options for coloured or black and white output images. The stereochemical annotations on the 2D depictions are generated using the Cahn-Ingold-Prelog (CIP) priority rules. To accomplish this, the Java package centres is used in conjunction with CDK. Additionally, the depict module is able to produce interactive 3D models of input structures. Figure A, B illustrates the application of the depict module to generate a 2D depiction with CIP annotations in colour on a scale of 512 x 512 pixels and with a 52° rotation. The depicted image with CIP annotations can be generated directly by using this call to the API: