When comparing the Vina and Vinardo scoring functions, Vinardo consistently favors conformations with even smaller DFT conformational strains than Vina. This effect, although small, is consistent and can be explained by our earlier observation that Vinardo generally estimates weaker intermolecular energies than Vina. Weaker intermolecular interactions can compensate less for intramolecular strains. Despite these small differences, it might be beneficial in practice to perform both QFVina and QFVinardo docking and combine the results.