Aptamers are short, single-stranded nucleotides that bind to specific targets such as proteins, molecules, or cells with high precision . Aptamers have low immunogenicity and are more stable, which distinguishes them from traditional antibodies . They also have higher versatility which allows them to target a wide range of molecules. SELEX (Systematic Evolution of Ligands by Exponential Enrichment) technique is used to select aptamers from a large pool . The sequences are bound, separated, and amplified in rounds in order to isolate the sequences that bind to the target call. Such synthetic production enables consistent quality and accurate modifications. The use of aptamers offers new solutions in medical, environmental, and drug developments. In molecular biology and drug development, docking is a computer method that forecasts the receptor-ligand interactions. To determine the strength and stability of the connection, the procedure entails creating a range of potential orientations and conformations for the small molecule inside the target protein's binding site. These poses are then assessed using a scoring algorithm. By forecasting the binding affinity and efficacy of possible drug candidates, this method assists in identifying and developing novel medicines.