Regardless of the exergonicity of the reaction, this approach can be of utility, and it brings new targets from the kineticthermodynamic relationship that move away from the main expected variable by its very definition, reaction energy. The extent to which this may be applied in the development of new methodology will be ultimately determined by the understanding of how different factors affect the parameters that guide the nonlinear kinetic-thermodynamic relationship. The answers to these questions should lie closer to the chemical properties, as the meaning of θ, Emin and Eeq is intrinsically fundamentally distinct from heuristic interpolation. Full accommodation of asynchronous processes, which would initially seem to preclude the monotonic response in this model, is ongoing in our laboratory and would further broaden the scope of applicability.