Although this paper is a tutorial on the GA methodology and not the quantum chemical methods, we explored if the molecular conformations had an effect on the polarizability, optical bandgap, and solvation energies in water and hexane. The Conformer-Rotamer Ensemble Sampling Tool (CREST) was used to sample accessible conformers of the champion hexamer discovered for all three chemical properties. The number of stable conformers for the hexamer champions for polarizability, optical bandgap, and solvation energy ratio were 1, 6, and 169 conformers, respectively. The polarizability, optical bandgap, and solvation energies in water and hexane were calculated using GFN2-xTB, sTD-DFT-xTB, and ALPB implicit solvation model in xTB, respectively, for all stable conformations of the 3 hexamers. Analysis of the distribution of polarizabilities found that the conformation has a negligible effect on the polarizability, with the average range in polarizability among conformers to be 0.18 Å 3 . Evaluating the optical bandgap conformed bandgap was a little trickier, due to limitations in calculating very small with sTD-DFT-xTB or lack of excitations under 5 eV. Only one hexamer yielded all valid optical bandgap calculations, and this gave a range of 0.085 eV among conformers, again showing the conformation has a minimal effect (ESI Figure ). The average range in solvation energy in water and hexane was 0.0049 E h and 0.0014 E h , respectively. Thus, exhaustive conformer sampling has minimal effect on these chemical properties and is not necessary for the purposes of this GA.