One example of how the ILSA modifications negatively interfere with result interpretation is with Target 7. Since the matching window 𝜖 was widened to account for two measured mass spectra drifting in opposing directions, the computed average RevMF score is comparable with both heroin and fluoxetine. Taking all metrics and results into consideration, an analyst should notice that the mass difference (Δ𝑚/𝑧) between the target m/z and the reference m/z is smaller for heroin than it is for fluoxetine, and that there are several other explained targets in the mixture that support the notion that heroin is a mixture component. That said, there is still room for improvement with ILSA scoring metrics and this is work we continue to pursue.