Interestingly, the large entropic penalties observed in DC-SIGN binding appeared to have diminished and replaced with a small favourable entropic term. Overall, these results indicate that DC-SIGNR binding exhibits a smaller favourable enthalpy term than that observed for DC-SIGN, although this has been partially compensated by a small favourable entropic term, leading to only slightly smaller binding ΔG 0 s than those of DC-SIGN.