The simplest version of a cheminformatics tool bot has been operating on @souyakuchan account [10] since 2017 in the form of a bot that draws a 2D structural formula image for replies containing a SMILES or an IUPAC name . The retrosynthesis bot was implemented in December 2020 for the blog event called Drug Discovery (dry) Advent Calendar 2020 hosted by @souyakuchan.