Similar conclusions have also been discovered from direct on-the-fly ab-initio molecular dynamics simulations in Ref. 380. In this work, the deprotection reaction of 1phenyl-2-trimethylsilylacetylene (PTA), experimentally studied in Ref. 108 (see Fig. 19b) was investigated in the gas phase inside the cavity. The direct numerical simulations reveal that the cavity mode mediates the vibrational energy transfer between different vibrational modes, resulting in a shorter bond distance for the breaking bond during the reaction, thus in principle, suppressing the reaction. Interestingly, there is a resonant effect where the reactive bond distance will reach its minimum length when the cavity frequency matches the vibrational frequency of this bond. Future work is needed to investigate if such an effect still survives in the condensed phase (when considering the solvents) as well as if the bond shorting effect is equivalent to the reaction rate constant reduction.