As evident from the above discussion, the studies reported on (H 2 O) m (H 2 S) n mixed clusters are limited to structure determination and their BEs calculation. Furthermore, the evolution of HB energies has been carried out only in the smaller clusters (mostly in dimers). In order to understand the physical phenomenon at the molecular level, a deeper comprehension of individual HB strength is indispensable. Importantly, there is no direct information available in the literature about the energetics of these individual HBs and cooperativity in these clusters. By employing the cardinality principle, Deshmukh and Gadre developed a molecular tailoring approach based (MTA-based) method for the estimation of individual intramolecular HB energy (IHBE) in a variety of systems. This MTA-based methodology was further extended by Deshmukh et al., for estimating the individual HB energy and cooperativity in various molecular clusters. Patkar and Deshmukh utilized this method for estimation of self-and cross-associated HB energies in mixed molecular clusters. In order to explore the energetics of individual HBs in (H 2 O) m (H 2 S) n mixed clusters, we employed the molecular tailoring approach (MTA) based method in the present study.