Further investigation revealed that the stabilization of D-arginine comes from two factors: the stacking interactions by the guanidinium group and electrostatic stabilization by the c-alpha part in the D-Arginine. In case of L-arginine, due to mirror symmetry, the electrostatic stabilization is not favorable. Therefore, in case of L-arginine, the stabilization majorly occurred due to the interaction of the sugar -backbone towards the arginine side groups. As the D-arginine stabilizes the terminal base pairs through multitude of interactions, it prevents unfolding of the RNA. In case of L-arginine, the side interaction does not help the stabilization.