In addition, we performed an external validation of the models with purchased compounds. The selection process of choosing the compounds from the vendor is described in the Materials and Methods section. Out of the 127 compounds in this dataset, in the CPA -104 are non-lysosomotropic while the remaining 23 are lysosomotropic. The Descriptor model's balanced accuracy is 0.70 while its Cohen's kappa score is 0.29. The Fingerprint model's balanced accuracy is 0.62 and its Cohen's kappa is 0.16. The confusion matrices of these models' performances are shown in the Figure .