The acid dissociation and distribution coefficient measurements prepared for this study were entirely solubility-based. Solubility workflows are easily adaptable to the current automated platforms available for sample preparation and high throughput chromatography for determining drug concentrations in a variety of solutions. Utilizing an HTE approach ensured that a multitude of drug substances and solvent systems could be analyzed in a rapid manner, with limited availability of raw materials. The conventional shake-flask method continues to remain as the gold standard for traditional distribution coefficient measurements, despite the high drug substance demand for experiments involving large volumes of solvents . The automated method presented here, for determining logD, has similarities to the shake-flask method yet was performed at a significantly lower volume. However, instead of manually shaking the flask, the sample vials were vortexed for no less than 30 minutes, and then allowed to reach equilibrium.