At the time of writing (May 2024), NAPROC-13 had 24,722 compounds. While most entries in this webbased application originate from plant sources, it also includes some marine and microbiological NPs, reflecting recent revisions in their structures. It is noteworthy that the priority for entries in NAPROC-13 currently lies with substances whose structures have undergone revision. By geographical distribution, systematic introductions of NPs are limited to those from Panama and El Salvador. Most of the entries in NAPROC-13 come from various unspecified countries worldwide. For comparisons, we used the following as reference compound databases: the FDA set (update until 04 January 2023) with 2,324 unique compounds, and the Universal Natural Product Database -Subset A (UNPD-A), which includes the 14,994 most diverse compounds from NPs reported in the UNPD, selected using the MaxMin algorithm. In addition, a set of reported solvents of analysis for NAPROC-13 compound analyses was created from the original and curated database, as an approximation to the solubility of the chemical compounds in deuterated solvents. The COCONUT database was included as an approximation to the whole reported compounds of natural origin, to estimate the region of the chemical space of NPs that is covered by NAPROC-13. Compounds in NAPROC-13, UNPD-A, and FDA-approved drugs encoded as Simplified Molecular Input Line Entry System (SMILES) were standardized using the open-source cheminformatics toolkit RDKit, version 2023.09.4 and MolVS. According to a standardized protocol, Three types of molecular fingerprints with different designs were calculated: Molecular ACCes System (MACCS) keys (166-bits), extended connectivity fingerprint (ECFP) of 1024-bits with diameter 4 (ECFP4) and diameter 6 (ECFP6), and MinHashed atom pair fingerprint up to a diameter of four bonds (MAP4). Structural content and diversity