The COVID-19 pandemic has affected many aspects of daily life beyond the direct effects of the virus, and we hypothesized that these changes would be visible in the organic chemical signature of wastewater. Our objectives were to characterize temporal variation of chemical contaminants in sewage sludge during the COVID-19 outbreak and associated lockdown and to relate our findings to the health and activities of local residents as well as broader global trends. We used both targeted and suspect screening methods to cover a broad range of contaminants including common analytes such as pharmaceuticals and illicit drugs , but also more unusual compounds for wastewater epidemiology studies such as disinfectants, UV-filters, and pesticides. Previous studies evaluating chemical concentrations in wastewater during the COVID-19 pandemic have focused on limited numbers of analytesprimarily licit and illicit drugs . Additionally, to our knowledge, this study is the first to report trends in wastewater concentrations for chemicals with direct significance to the COVID-19 pandemic including hydroxychloroquine and disinfectants. Samples were taken at the East Shore Water Pollution Abatement Facility, New Haven, CT USA, where SARS-CoV-2 concentrations and cased data have already been measured and published . Daily collection of primary sludge samples and analysis for SARS-CoV-2 RNA began March 19, 2020 and has continued through 2020 .