The heme theory found through calculations that ORF3a would attack hemoglobin(102). Some perplexing signs are now regarding oxygen supply and hemolysis in COVID-19 patients whose red blood cells are attacked. COVID-19 patients are still able to dance and sing despite low blood oxygen saturation. However, this situation will not last long, and as a result, hypoxia will worsen, and the condition will deteriorate rapidly. It is referred to as the "happy hypoxia paradox"(103). The Hb oxygen dissociation curve represents the relationship between blood oxygen partial pressure and hemoglobin oxygen saturation. P50 denotes the oxygen partial pressure at which hemoglobin is 50% oxygen saturated. When the oxygen affinity of hemoglobin increases, the dissociation curve of oxyhemoglobin shifts to the left. It lowers P50, thereby decreasing tissue oxygen delivery. It has been reported that in some COVID-19 patients, the oxygen dissociation curve does not shift to the left or right(104). The mixed-effects model (with pH and PCO2 as covariates) revealed that SARS-CoV2 had a small but significant effect on the PO2/SO2 relationship and appeared to be less sensitive to PCO2 in COVID-19 patients(105). In comparison to other pneumonia patients, there is no evidence of hemolysis. These researchers believe that there has been no significant change in hemoglobin's oxygen-carrying capacity(106). That hemoglobin's affinity for oxygen has remained constant(107). The problem is referred to as the "oxygen dissociation curve problem." The oxygen affinity of hemoglobin in COVID-19 patients are the subjects of intense academic debate(108).