Using the default parameters for downsampling to a target of 25% membership (671 molecules), the initial population of 2683 was downsampled to 763 molecules. While the topography of the original chemical point cloud (Figures &) and the downsampled point cloud (Figures &) remain similar, and the distributions for selected descriptors is roughly scaled down (Figure ), a major discrepancy in the targeted membership from downsampling is apparent. A large portion of this discrepancy is due to 103 clusters having targeted memberships of zero, with one member being retained as the nearest neighbor to the cluster centroid. By using the visualization flag, a large amount of clusters can be noted in addition to many chemical singletons (Figures ).