Researchers have made significant progress in developing valuable and effective detection techniques based on the specific recognition of cancer biomarkers. Multiple methods have been explored including enzyme-linked immunosorbent assay (ELISA) , colorimetric assay , electrochemical assay , polymerase chain reaction (PCR) , surface plasmon resonance (SPR), surface enhanced Raman spectroscopy (SERS) , fluorescence methods , and others. However, despite intense efforts, cancer biosensors are yet to achieve satisfactory clinical diagnostic standards.