As evidenced in Figure , the most recurrent EVP in this dataset is [2,5,7] followed by [2,5] and [2,3,5]. In turn, the dEVP with the highest probability, namely the number of simultaneous substitutions, is tri-substitution, followed by disubstitution (Figure ). This gives an idea of the most studied substitution patterns and, interestingly, suggests that there are potentially underrepresented combinations of R-groups that can be useful to explore. For instance, the plot in Figure shows that EVPs [3,5] and [3,5,7] are underrepresented, indicating a potential starting point for designing new analogs.