Dissolved organic matter (DOM), another critical component in environmentally relevant systems, can also affect the oxidation of organic contaminants via interactions in solution or after DOM adsorption onto mineral surfaces (i.e., after the formation of organo-mineral associations, OMAs). Previous studies have shown the oxidation kinetics of phenolic compounds by Mn oxides (birnessite) can change in the presence of soil or water derived DOM. For example, Swenson et al. showed that slower degradation rates result from competitive sorption between phenol and DOM coupled to reductive dissolution of birnessite. Conversely, they suggested that the cross-coupling reactions at the surface of DOM-MnO2 association promote the degradation of phenolic compounds where enhanced DOM association led to formation of DOM-phenoxy radical species (via a one-electron-transfer between phenolic moieties of DOM and MnO2). In other case, Liu et al. reported that a DNA macromolecule due to very high adsorption affinity mainly via its backbone phosphate, can block active sites of MnO2 leading to suppressed oxidation of fluorescent peroxidase substrates. The inhibitory impact of organic association also is derived by surface passivation, where the pre-degradation of one organic constituent lower abiotic degradation of another which is associated to the dissolution/reduction mechanism. Proteinaceous materials derived from plant and microbial sources are a major active component of DOM in soils, sediments and aquatic environments. Proteins have a high adsorption affinity to diverse mineral surfaces, such as iron (oxy)hydroxides, layer aluminosilicates, manganese oxides and other natural and engineered surfaces. Generally, proteins unfold upon adsorption (e.g., loss of α-helices with conversion to turns), thus increasing the overall adhesive strength by the addition of hydrophobic interactions to electrostatic binding that leads to the formation of stable organo-mineral associations (OMAs). Surface alteration by sorbed biomolecules may influence retention, transformation, and bioavailability of other organic constituents in natural systems. Although investigations of glyphosate's degradation on bare mineral surfaces are plentiful, the role of OMAs in governing the dynamics of both sorption-desorption and transformation of xenobiotics like glyphosate remains largely unexplored. Research utilizing heterogeneous organo-mineral associations will help us acquire a more realistic perspective of glyphosate's fate in the environment.