Mycotoxins are natural toxins produced by fungi, and are adventitiously introduced into poultry and food-supply chains to threaten human health. In particular, worldwide contamination of agricultural products by ochratoxin A (OTA, Fig. ), which is a potent carcinogen with nephrotoxicity and heptatotoxicity, is a serious concern in grains, beans (including coffee), and wine. Inhibition of mycotoxin synthesis has been studied to solve these issues, but the more practical method is to efficiently detect the chemicals at the boundaries of the food supply. However, foods contain various chemical compounds that hinder their detection using conventional techniques, including spectroscopy or mass spectrometry: The detection of OTA requires sample clean-up prior to analysis. For example, coffee beans contain a large number of fatty ingredients that take in various phytochemicals such as 5~10wt% of chlorogenic acids, 11 1~2wt% of caffeine, lignans, alkaloid trigonelline, vitamin B3 (niacin), and other quinic acids. As such, the facile and efficient separation of OTA from highly contaminated food matrices will be of great importance in analytical chemistry benefiting human health. The use of immunoaffinity, aptamers, metal-organic frameworks, microporous MgO, mesoporous silica, graphene oxides, nanocarbon materials, DNA, and other polymer nanoparticles has been studied extensively to achieve high affinity toward OTA. However, the non-specific adsorption can be significant in aqueous solutions as in the case of bovine serum albumin (BSA), which could hinder the efficient separation of OTA from heavily contaminated food matrices. Thus, the development of non-aqueous molecular interactions with OTA is desired for efficient and facile separation.