Representative 3-step, tandem sequence. As the scope of reactions feasible under aqueous micellar conditions continues to broaden, 73 so too do the benefits of telescoping, yielding significant efficiencies in both "time" and "pot" 75 economies. These advantages, alongside organic waste reduction, have become focal points in recent scholarly reports and analyses highlighting the imperative of optimizing reaction methodologies for both sustainability and productivity. In Scheme 11, a 3-step tandem sequence is illustrated that employs some of the more commonly used reactions in the pharmaceutical industry. Hence, an initial Pd-catalyzed amination between 4nitroaniline and a highly functionalized aryl fluorosulfate derived from ezetimibe (12a) was carried out to afford the corresponding secondary amine. The resulting crude mixture was acidified using conc. HCl to pH 3-4, after which the mixture was subjected to nitro group reduction using carbonyl iron powder (CIP) in the same pot. The resulting aniline, used crude after filtration away from the CIP, was subjected to amide bond formation upon treatment with the thioester 78 of N-Boc t-leucine (used previously en route to nirmatrelvir), to afford product 40 in 64% isolated yield over 3 steps.