In the trifluoromethylthiolation campaign (Figure ), five reaction parameters and two objective functions were optimized simultaneously. The photochemistry was conducted in the Signify Eagle Reactor, which utilizes PFA tubing with a 0.8 mm I.D. and a total volume of 2.85 mL. To provide the necessary light source, a chip-on-board (COB) UV LED system with a tunable light intensity ranging from 0 to 144 W of optical power was employed. The screening chemical space encompassed five continuous parameters: Phth-SCF3 concentration, H-donor equivalents, TBADT photocatalyst loading, residence time and light intensity. The objective functions chosen for optimization were either yield [%] or simultaneously the yield [%] and throughput [mmol h ] of the SCF3-bearing molecules. To ensure fair comparisons between different reactor systems, we chose to convert the productivities into space-time yield (STY) (g•L -1 •h -1 ). This normalization factorizes the reactor volume, allowing for a more equitable assessment of performance across varying reactor sizes.