To a reaction vial containing a substituted amine (0.25 mmol, 1.25 eq.) was added triethylamine (5 eq.) dropwise in one portion and the contents were stirred at 75 o C until a clear solution was obtained. Methanol (0.5 mL) was added to the mixture in those cases where a clear solution was not observed after 5 min. 2,4-Dichloro-5-phenylthieno[2,3-d]pyrimidine (0.2 mmol, 1 eq.) was added in one portion and the solution stirred at 75 o C and the reaction was monitored by TLC over 12-24 h for consumption of thienopyrimidine. The reaction contents were cooled to room temperature, transferred into a separatory funnel containing water (30 mL) and CH2Cl2 (15 mL). The organic layer was extracted, washed with brine, dried over anhydrous sodium sulfate, and evaporated to yield a crude product that was purified by flash chromatography using a gradient elution of ethyl acetate/hexane.