A commercial QqTOF platform, ZenoTOF 7600 system from SCIEX, was modified to add UVPD to CID and EAD fragmentation. Product ion spectra could be acquired for 168 pesticides in CID and EAD and 156 in UVPD at 266 nm. UVPD provided additional spectra information complementary to CID and EAD, which can be used for confirmatory analysis. Quantitative analysis could also benefit from different activation techniques with regard to selectivity, as fragmentation of co-eluting isobaric interferences would behave differently. A 213 nm more energetic laser has shown better fragmentation, and its application is under investigation. With the current software features LC-MS analyses can be performed either with DDA or DIA using a single activation method or in product ion mode (MRM HR) with all three activation techniques in the same acquisition with or without Zeno trapping. As proof of concept, the novel platform's performance and application were investigated with the screening of pesticides in juice and wine samples. DIA SWATH acquisition using CID was found to be a versatile approach for general screening where each analysis can be re-interrogated at any time, while the use of all three acquisition activation methods in a single LC-MS improves the identification of the analytes.