Influenza viruses are a serious health hazard for human health that cause numerous deaths every year and also impact the economy of the world . Three to five million influenza virus cases appear every year worldwide . Influenza viruses lead to pandemics which result in illness, financial losses as well as several deaths. Influenza viruses rely upon the genes of host organisms to multiply and replicate. By utilizing RNAi screens these host genes required for replication might be found, which might be useful for reducing the virus multiplication and ultimately the pandemics (Orr-Burks et al., 2021). Influenza virus is responsible for causing seasonal pandemics which affect the respiratory tract. Influenza A viruses mostly occur in humans. Influenza virus initiates its entry into the host cells when its HA protein binds to sialic receptors of humans which causes the virus to merge properly into the cell membrane of humans.