To the best of our knowledge, the strategy to use mixtures to optimize SF syntheses of Au NPs has not been reported before. It is here hypothesized that a small amount of glycerol helps to achieve size control towards smaller NPs by playing a role in the initial steps of the synthesis by favoring a faster formation of the NPs. Therefore, we explore for the first time to the best our knowledge the possible benefits of using [mono-alcohol + polyols] mixtures as the source of reducing agents for the RT SF colloidal syntheses of Au NPs, with a focus on high mono-alcohols content.