Here, we review the computational workflows and associated hit rates of the 23 teams who participated in CACHE #2. In an initial "hit identification" round (Round 1), each team selected up to 100 compounds from the Enamine catalog resulting in 1957 molecules that were procured and tested using Surface Plasmon Resonance (SPR), a direct biophysical binding assay. Each computational group was provided with experimental data on their respective compounds and asked to select up to 50 commercial analogs of their experimentally confirmed compounds of interest. The goal of this "hit expansion" round (Round 2) was to establish chemical series with multiple compounds experimentally confirmed to further build confidence in determining successful computational workflows. In parallel, all teams were asked to predict active molecules from the library composed of all Round 1 compounds collectively selected by all participants, a complementary evaluation mechanism where participants predict from the same library.