The differences in target coverage (i.e. as "P" in DARCP) shown in Fig. are noteworthy and persists despite the ChEMBL/BindingDB selective mirroring. As for PMID coverage it would be useful to know which types of selectivity were responsible for this divergence in connectivity. For BindingDB some unique proteins are likely to be patent-only but exploring further causes of complementary target coverage are outside the scope of this work.