In conclusion, the findings were compared to two popular and successful predictive methods, UNIFAC and MOSCED. Comparison to these models allows us to assess the viability of taking the SMx models into further chemical engineering applications. A recent 2019 study conducted by Brouwer and Schuur , previously showed MOSCED was the top performing model in an comparative study to predict limiting activity coefficients at 298.15 K. Our comparison further confirms that MOSCED is the top performing model in comparison to UNIFAC and the SM12 universal continuum solvent model, yet it is limited by the number of compounds and systems it can model. UNIFAC and the SM12 universal continuum solvent model are comparable in performance among the three reference sets. This suggests that the SMx models have potential to be used and tested in chemical engineering applications such as the prediction of phase equilibrium There is also opportunity for synergy between SM12, UNIFAC, and MOSCED.