Due to the complementarity of 13 C NMR and LC-HRMS 2 , their combined use can potentially increase the number of detected compounds and significantly enhance the confidence level in their identification. Consequently, various strategies have been developed recently, such as online (e.g., LC-MS-SPE-NMR) and offline approaches (e.g. multiblock).(3) However, the former requires bulky and expensive equipment (i.e., ensuring compatibility of experimental conditions), while the latter enables in-depth data exploration but requires advanced expertise in chemometrics.