Three different solvent extracts were prepared by incubating three sets of 10 Instamorph pellets in 5 mL analytical grade methanol (~30 mg/mL) for 24 h at room temperature in combusted borosilicate glass vials with PTFE/F217 lined caps. Methanol was chosen because it can extract polar compounds 1,2,5 without dissolving PCL. After extraction, half of the extracts (2.5 mL) were evaporated under a gentle stream of nitrogen at room temperature and reconstituted in 100 µL of molecular biology grade dimethyl sulfoxide (DMSO) for high-throughput screening bioassays. Additionally, 1.5 mL of an extract was exposed to a gentle stream of nitrogen at room temperature until dryness and reconstituted in 100 µL analytical grade dichloromethane (DCM) for non- targeted analyses by GC×GC. An extraction blank without plastic was also prepared for the bioassays and the GC analyses. Specifics of each extract are provided in Table .