Default values amount to d 0 = 0, n = 6, and m = 12. The adjustable parameter r 0 describes the turning point of the switching function and is chosen to be 1.5 Å here, cf. Fig. . This value should be reached for typical reaction coordinate values near a TS. Ultimately, along the CVs, Gaussian bells pile up during the simulation so that the bias can adapt itself to the barriers of the relevant transitions, as is shown in Fig. . The height and width of the Gaussian pulses, as well as the deposition rate inuence not only the eectiveness, but also the eciency of the acceleration, which is represented by the parameters HEIGHT in unit kcal/mol, SIGMA, and PACE in number of time steps, respectively.