A recent study demonstrated the potential of a bi-functional compound containing the small molecule (+)-JQ1 warhead to induce the nuclear localization of cytoplasmic proteins 13 . (+)-JQ1 is a widely studied potent binder for members of the BET bromodomain family of proteins. While most of these proteins have primary roles in the nucleus , they can perform secondary functions in the cytoplasm, especially in the context of cellular signalling and stress responses . Thus, BET bromodomain proteins display an intermediary shuttling state between the nucleus and cytoplasm.