In our multicomponent droplet system, the NES-YK13-sfGFP acts as a scaffolding protein that maintains the droplet, and the monomeric fluorescent proteins (NES-YK13-mCherry and YK13-miRFP670-myc) are recruited into the YK-based droplet as client proteins. This scaffold/client concept is consistent with the mechanism of protein assembly behind natural liquid condensates . For instance, promyelocytic leukemia (PML) protein acts as a scaffold for the PML nucleus, while Sp100 and BLM client proteins partition into the structure . In stress granules, a client-enriched shell is formed around a core consisting of scaffolding proteins such as G3BP1 . The estimates from the reported coarse-grained MD calculations suggested the importance of the network connectivity between scaffolds in the maintenance of biomolecular condensates .