Medicinal plants contain various phytochemicals, which vary based on species, geographical location, and the nature of the extracting solvent . Several studies suggest that aqueous plant extracts may effectively treat bacterial infections, sometimes demonstrating comparable or superior efficacy to certain antibiotics while potentially reducing the development of bacterial resistance . Drug repurposing also offers a promising strategy in the fight against resistant infections. This approach involves using known compounds or existing drugs to treat challenging, rare, resistant, or difficult-to-treat diseases . Two potent classes of bioactive compounds in medicinal chemistry, known for their diverse pharmacological activities, present a new opportunity to treat recalcitrant infections. For instance, the clinical inhibitory effects of riboprine and forodesine against SARS-CoV-2 replication are notable. These compounds exhibit triple synergistic inhibitory activities against the enzymes RdRp, ExoN, and adenosine kinase (ADK), making them effective against the virus . This paper proposes strategies to develop, modify, or optimize potent active compounds using a combinatorial synthetic method utilizing phytoconstituents present in plant extracts aiming to enhance the efficacy and reduce the resistance potential of existing or new compounds by employing ATR-FTIR, GC-MS and antibacterial results from related literatures.