Last, in figure we consider the case of SM39. For this case the ring sulfur is now in a sulfone group. The results are similar to SM36 in that in water-saturated 1-octanol the local density around both sulfone groups increases as compared to neat 1-octanol. However, the relative increases is less than that observed for SM36. While the value of log 10 P o * /w 1 is greater than log 10 P o/w 1 for both SM36 and SM39, the increase is greater for SM36 than SM39. Comparing the partial charges used by the force field for the ring sulfoxide group in SM36 and ring sulfone group in SM39, the O and S partial charges are -0.54 and +0.29, respectively for sulfoxide, and -0.59 and 1.06, respectively, for sulfone. While the O carries a similar partial charge in both cases, the local O=S dipole will be larger in the sulfoxide group than each of the O=S dipoles in sulfone. As a result, the sulfoxide group is a stronger hydrogen bond acceptor.