The DNA templates considered here are represented in Scheme 1. The UBP is placed inside the DNA duplex in two possible ways. In one case DS-DN is incorporated into the middle of a 9-mer DNA duplex designated as MUD (5'-GCGCDSGCGC-3', Scheme 1). In the MUD structure a DS-DN pair has been placed with different orientations. The Non-Watson-Crick DNA models have been created through placement of the UBP as intercalated forms, denoted MUDSYN and MUDANTI. The parallel model, corresponding to a canonical Watson-Crick DNA duplex, is denoted MUDPAR.