Comparing the top non-aniline containing D2B hits revealed that this brief in silico screening resulted in compounds with similar nanomolar M pro inhibition, at 50 and 52 nM respectively, compared to 45 nM and 61 nM, highlighting this framework's capabilities not only in uncovering potent compounds that would have been discarded in a traditional D2B pipeline but also as a valuable high throughput in silico screening module.