ORF8 is secreted into the blood of infected humans both in N-linked glycosylated ( 78 N) and unglycosylated forms, inducing the highest immunogenicity among the SARS-CoV-2 proteins, specially immunodominant is its amino-terminal α-helix . The ORF8 accessory protein has been proposed to modulate the recognition of viral antigens via antigen presenting monocytes, showing a stronger interaction with CD14+ monocytes using their NLPR3 receptor.