Prior to this study, no reported computational studies reported that hesperidin, a citrus peel natural product, may inhibit SARS-CoV-2 helicase, although computational docking experiments by Adem et al. and Mosquer-Yuqui et al. identified hesperidin as a potential treatment . Adem et al. used Molegro Virtual Docker 7 to analyze 80 flavonoid compounds binding to M pro and found hesperidin had the highest predicted binding affinity . Similarly, Mosquer-Yuqui et al. screened 92 phytochemicals from Andean medicinal plants against SARS-CoV-2 M pro and RNA-dependent RNA polymerase (RdRp) using molecular docking . Unlike Adem et al., they subsequently simulated the interactions of the top-ranked natural products, including hesperidin, using GROMACS MD. Hesperidin was also suggested as an antiviral candidate by other studies . For example, Meneguzzo et al. reported that hesperidin had a high binding affinity to ACE2 and could block SARS-CoV-2 entry via this receptor (Figure ), outperforming drugs already recommended for human Covid-19 trials 27 . There are also no prior reports of predicted activity of cabotegravir against the SARS-CoV-2 helicase, although Petersen et al. predicted that cabotegravir might bind to M pro using a combination of molecular docking and MD calculations . Similarly, no studies have reported conivaptan as having potential helicase activity, although Gul et al. predicted conivaptan would have activity against SARS-CoV-2 RdRp 29 . Potential conivaptan binding to the SARS-CoV-2 nsp9 replicase was found by Chandel et al. using a combination of Autodock screening followed by MD simulations . Several other recent computational studies have also reported potential binding of conivaptan to various SARS-CoV-2 targets (see summary in Piplani et al.) .