In 1999, Mohan and Mishra carried out a molecular structure activity relationship study focused on nonsteroidal anti-inflammatory drugs within revealed a localized negative region around the carboxylate oxygen, while the positive region was observed to be localized around the cyclopropyl group and the piperazine ring. The anti-bacterial activity of all the synthesized complexes when compared to sparfloxacin against all selected strains are confirmed. Linezolid is an antibiotic employed for treating infections caused by Gram-positive bacteria that have become resistant to other antibiotics. The MESP analysis shows that the maximum and minimum values of linezolid are located at the carbonyl oxygen and the hydrogen of the NH regions, respectively. Recently, MESP is utilized to understand the binding field of SARS-CoV-2 S-protein: human ACE2 interface complex (PDB ID: 2AJF) . The proline portion (bottom region) is observed as electron-rich (blue area) while the histidine portion (top region) appears as electron-deficient (red area). This suggests the highly polar binding domain for the SARS-CoV-2 S-protein: human ACE2 interface.