User-friendly open-source tools: In medicinal chemistry, using virtual-screening (VS) software is crucial but challenging. Open-source tools often require programming knowledge and are rarely updated, limiting their adoption by chemists with limited computational skills. Commercial tools, while user-friendly, are expensive and inaccessible to smaller academic groups. Our analysis shows that commercial tools do not necessarily perform better on our datasets. To address these issues, we introduce DockM8, a user-friendly framework that requires minimal programming expertise and uses open-source components. This approach makes virtual screening more accessible and challenges the idea that higher cost equates to higher quality. DockM8 aims to provide an easy-to-use VS workflow with extensive documentation for operation and installation on various platforms. It includes a basic graphical user interface to minimize coding and command-line usage.