Our results indicate that the correlation between experimental and predicted results is on par with the FEP+ method, achieving a Pearson correlation coefficient of 0.73, a Kendall τ of 0.46, and an RMSE of 2.61 kcal•mol -1 (comparable to FEP+: Pearson correlation coefficient of 0.76, Kendall τ of 0.24, and RMSE of 2.87 kcal•mol -1 ).