While the Shannon entropy may not be a perfect tool for analyzing this issue, we find it helpful here. For a particular transition, a value of 0 indicates all predictions agreed as to the sign of the free energy change (whether positive, negative, or neutral), while values greater than 0 reflect an increasing level of disagreement in the sign of the prediction. 32 of the microstates had a H value of 0, 21 had a values that ranged from 0.5-0.7, and 3 microstates had values greater than 0.9 (the highest level of disagreement).