To summarize the route to enyne 22, a highly enantioselective conjugate borylation of an easily accessible cyclohexadienone sets the stage for all subsequent transformations to occur with both high chemo-and diastereoselective control. From an efficiency and scalability perspective, it traverses through 3 isolated intermediates from inexpensive p-cresol and can be conducted at noncryogenic temperatures on multi-gram scale. This route thus represents one of the most processfriendly paths to date to a fully synthetic A-ring VitD module.