Other noteworthy approaches to approximate the full CCSDT method include the CCn family of methods, the nCC family, and CCSDT-n methods. CCSD(T) has become known as the "gold standard" method in quantum chemistry due to its lower computational expense, scaling O(N 7 ) as opposed to the O(N 8 ) required in a full treatment of triples, and accuracy resulting from a favorable error cancellation through the neglect of higher order triples terms that is observed in many systems. A canonical CCSD(T) computation is still prohibitively expensive for molecules larger than 30 atoms using typical computing resources. Because of this, it remains a popular area of research to devise the fastest approximations to canonical CCSD(T) without impacting accuracy. These include but are not limited to density-fitting (DF)/resolution of the identity (RI) , rank reduction (RR) , tensor hypercontraction (THC) , clusterin-molecule (CIM) , projected atomic orbital (PAO), as well as pair natural orbital (PNO) approaches. Pair natural orbital (PNO) approaches have increased in popularity in recent years due its asymptotic linear-scaling cost, afforability for larger molecules, as well as being systematically convergent to canonical CCSD(T) through the tightening of parameters. The latter include, in particular, the domain-based local pair natural orbital (DLPNO) approach of Neese and coworkers, which relies on the "cascaded" 67 formation of PNOs through sparse PAOs, giving them their efficiency. The DLPNO-CCSD(T 0 ) algorithm in the ORCA software package has been used to run a computation on 350-atom linear alkane in the def2-TZVPP basis (1252 atoms, 20678 basis functions), while the DLPNO-CCSD(T) algorithm, available in both ORCA and Psi4, has been performed on a whole insulin peptide in the def2-SV(P) basis (787 atoms, 6458 basis functions). For reader clarity, DLPNO-CCSD(T 0 ) represents the initial implementation of DLPNO-CCSD(T) that does not account for the contribution of off-diagonal local molecular orbital (LMO) Fock matrix elements, and is also known as the semicanonical approximation. Since these LMOs do not represent canonical Hartree-Fock orbitals, the contribution of their off-diagonal elements need to be iteratively accounted for to match canonical CCSD(T) values, which is performed in the iterative DLPNO-(T) algorithm. These computations prove that these algorithms can be performed on systems orders of magnitude larger than what is achievable with canonical CCSD(T). Such methods include the DLPNO-CCSD(T) algorithm in ORCA, 68 Psi4 69 , and SERENITY; the PNO-LCCSD(T) method in Molpro; and the LNO-CCSD(T) method in MRCC. The errors of the local approximations relative to canonical CCSD(T) are controllable through the proper selection of parameters. These errors have been shown to be proportional to system size (i.e. "size extensive") .