MicroRNAs (miRNAs) are small noncoding RNAs that typically have around 22 nucleotides in length . MiRNAs have shown potential to serve as biomarkers for diagnosing cancer, since the expression of several miRNAs varies between normal and tumorous tissue . In a study of 10,841 laryngeal cancer cases, Broseghini and co-workers found that 69 miRNAs are upregulated in the tumor and 95 miRNAs are downregulated in tumor compared to normal mucosa-the downregulated miRNAs are putative tumor suppressor miRNAs . MiRNAs are found to be linked to several cancers because they can affect mRNA translation through the repression of specific mRNAs during translation or accelerating the destruction of mRNAs, which can trigger cancers, and it has been shown that specific miRNAs are linked to the occurrence of tumors . Since miRNAs are stable in bodily fluids like blood, urine, and saliva, they offer a minimally invasive means of assessing disease states and therapeutic efficacy . Studies analyzing mice with miRNA overexpression or ablation have shown causal links between miRNAs and cancer development . Thus, these studies show the importance and relevance in studying miRNA as biomarkers for laryngeal cancer diagnosis.