To demonstrate the capability of Loxodynamics in capturing chemical reactivity, we selected two prototypical reactions: the S N 2 nucleophilic substitution of chloromethane by a fluoride anion and the gas-phase Diels-Alder reaction between ethylene and 1,3-butadiene. These reactions exemplify key aspects of reactivity, including simultaneous bond rearrangement (synchronous bond breaking and formation) and significant differences in the shape of the reactant and product basins as well as asymmetric barrier heights in the forward and reverse directions.