Most of those top-children conformers were molecules centered around a benzene ring displaying ~ 3-fold star-like structures, with different atom small variations. Most top-children conformers predicted by the 1301 co-evolution were molecular scaffolds with 7 rings while those with 4-6 ring scaffolds were less abundant (Figure ). In contrast, most top-children conformers from the 6970 coevolution predicted 5 ring scaffolds while those with 6 rings were less abundant (Figure ). Despite their different number of rings, these top-children similarly cross-docked N-(SP) and C-terminal CSP α-helices (Figure ) targeting similar CSP amino acids (Table ).