Fragmentation with Conjugated Caps), MTA (Molecular Tailoring Approach) , GEBF (Generalized Energy Based Fragmentation) are examples as overlapping fragmentation methods. In these methods, the overcounted fragments are cancelled out to calculate the energy of the derivative subsystems. MFCC utilizes this methodology implicitly. Bottom-up approaches, based upon many-body interactions, first create small non-overlapping fragments to calculate the interactions between them. FMO (Fragment Molecular Orbital), In this article, we used an amalgamation of the two above-mentioned methods where after fragmenting the molecule based on simple chemical intuitions, we calculated the longrange vdW interaction energies between them via dipole-coupled quantum Drude oscillators.