Given that each IDAC tells us how well a solute molecule interacts with the solvent with respect to how well it interacts with itself, Fig. can potentially also give us some idea whether a given force field underestimates or overestimates the intermolecular forces between solvent and solute. The diagonal line in Fig. corresponds to the cases where the simulation agreed with the experiment. If a point is located below the diagonal line, the force field potentially underestimates solute -solvent interactions relative to solute -solute interactions. On the other hand, if a point is located above the diagonal line, the force field potentially overestimates solute -solvent interactions relative to solute -solute interactions. Having an extensive set of IDAC values allows us to look for systematic errors in the force field and how it describes particular functional groups and solvents, as has been done