Although the synthesis of (-)-1 is the shortest route disclosed thus far, one potential critique is that the chirality purchased from glycidol derivative 14 is ablated (18 to 21) and then reinstalled through asymmetric proton transfer (22 to 24). However, attempts to utilize derivatives of 18 in direct coupling almost always led to 21 and, from an efficiency standpoint, offered no advantage in step count as the TBS group needed to be removed and the primary alcohol functionalized further.