To further demonstrate the versatility of our developed process, we next evaluated its application for the carbonylation of the light alkane homologous series (C1-C4), which represents the most challenging task for our flow protocol. Indeed, carbonylation of gaseous alkanes requires the cleavage of some of the strongest C(sp )-H bonds and, in addition, the subsequent coupling of two gaseous components are required for this transformation. As we have demonstrated, alkyl radical capture with CO can occur rapidly for soluble alkanes.