To evaluate the wettability of S-309309, S-309309 alone or mixed with a water-soluble polymer was compressed to form tablets and then the water contact angle of each tablet was evaluated. The results are listed in Table . The contact angle of all tablets containing S-309309 and a water-soluble polymer was significantly lower compared with that of the tablet of S-309309 alone, indicating that the wettability of the tablets was improved by including a water-soluble polymer. Talukder et al. reported the contact angles of the poorly soluble drugs ibuprofen, nifedipine, and carbamazepine with 0.5% Hydroxypropyl cellulose (HPC) solution and water. It was found that the contact angles of 0.5% HPC solution on the drug surfaces were lower than the corresponding contact angles for water.