Despite the favorable pharmacokinetic properties of molecular glues, currently well-characterized molecular glues are limited. The understanding of their mode of action and design principles is still deficient, thus advanced research in the area is highly desirable. Advancement of the proximity-based platforms will be highly impactful for drug discovery. For instance, many disease-relevant undruggable proteins are known for having regions of intrinsic disorder 146 that cannot be targeted by conventional small molecule drugs, whereas molecular glues can make a significant impact. In binding to a disordered protein region, molecular glues induce order, thus conferring druggability. Therefore, careful screening using innovative approaches, may lead to a discovery of ligandable pockets in a variety of undruggable targets and could open the possibility to targeting intrinsically disordered regions of proteins, particularly such with a high degree of disorder, including transcription factors, adaptor/scaffolding proteins, and RNA binding proteins. Since the initial serendipitous findings of molecular glues, a bottleneck setback has been how to efficiently approach a molecular glue discovery and design. The currently applied methods mostly rely on intensive high-throughput chemical screening, followed by systematic validation and lead optimization.