Particular advantages of the MFCC scheme include the fact that it uses chemically intuitive fragments (i.e., the amino acid residues), its straight-forward implementation in combination with numerous quantum-chemical methods, and the possibility to execute the fragment calculations in an embarrassingly parallel fashion. The specific choice of conjugate caps ensures that all resulting fragment and cap molecules are chemically sensible and mimic the corresponding parts of the protein. However, the MFCC scheme is not exact and introduces errors compared to a supermolecular calculation for the full protein.