The segregation between polar and apolar domains generates multiple activation barriers for the aggregation of nanoparticles in ionic liquids due to the unfavorable superposition of layers of opposite nature when the particles get closer to each other, with the height of the main barrier before contact being larger than 60 kJ/mol and even secondary barriers can be higher than the thermal energy. Those barriers can provide kinetic stability to colloidal dispersions in ionic liquids without the need for additives.