After energy minimization of these structures with Protein Preparation Wizard 65 (see settings above), WaterMap simulations were carried out using the default parameters, which involved analyzing water molecules within a 10.0Å radius of the SII-P bound ligand. The simulations were run for a duration of 2.0 ns. 3D illustrations of the WaterMap results were made with PyMOL (The PyMOL Molecular Graphics System, Version 2.5.4 Schrödinger, LLC).