For the other properties that were considered in the following, only one system (LHA1) was used to present the results, as there were no signifi- cant differences when the different compositions were compared. As mentioned earlier, parameters for bonded interactions between different fragments were calculated using DBI. Further details about this approach can be found in section S1 of the supporting information. Figure shows the average values of the time evolutions of the bonds, angles, and dihedral angles between fragments. For the water content x water = 0.425, the average values for each bonded interaction are compared between the mapped and coarse-grained systems. The same plots for models with different water contents are shown in Figure . No significant differences or trends are visible when comparing models with different water contents. To achieve a better representation, the standard deviations are not shown. A good correlation is visible for all the bonded interactions. For some distributions of dihedral angles that run periodically over the [-180 • , 180 • ] interval, the deviations of the mean from the reference can be very large. Therefore, to achieve a better comparison, 360 • were added to the negative dihedral angles in such cases. Generally, the correlations show the applicability of DBI to these models, although only the average values are shown here, which does not yield information about the form of the potentials. Deviations could mainly be caused by cross-correlations between the bonded in-teractions, which are neglected using this approach. To achieve further fine-tuning, iterative matching could be applied, which would conversely increase the parametrization effort for each SOM model. In general, a trade-off between the parametrization effort, the simplicity of the model, and its performance has to be made. The current parametrization of bonded interactions can be regarded as achieving a good compromise in this regard. In this case, more accurate parametrized fragments are used as basic building blocks, with fixed parameters for the bonded interactions, and less accurate parametrized interactions between the fragments, which are relatively easy to obtain. Ideally, if they were available, generic bonded interaction parameters between the fragments would be applied, so that they would be completely independent of an atomistic trajectory. We are currently working on a tool that can convert atomistic VSOMM2 models into a Martini 3 representation using generic bonded interaction parameters, without the need for a reference trajectory.