To this end, we first calculated the water permeability through membranes from all simulations in the NMRlipids Databank using the general workflow depicted in Fig. . The resulting non-zero values range between 0.3-322 µm/s with the mean of 14 µm/s and median of 8 µm/s. These values agree with the previously reported simulation results , but are on average larger than experimental values reported for PC lipids in the liquid crystalline phase, 0.19-0.33 µm/s . Using the workflow depicted in Fig. , we then plotted the observed permeabilities and their histogrammed values in Figs. as a function of temperature, membrane thickness, area per lipid, and acyl chain order. As expected, the permeability increases with the temperature, giving an average energy barrier of 14 ± 3 k B T for the water permeation from the Arrhenius plot in Fig. . On the other hand, the water permeability on average decreases when membranes become more packed, that is, with decreasing area per lipid and increasing thickness and acyl chain order (Figs. ). Permeation of water through bilayers depends on membrane properties also according to previous studies, but there is no established consensus on whether the area per lipid or bilayer thickness is the main parameter determining the permeability. Our analysis over the NMRlipids Databank, containing significantly more data than what was available in previous studies, suggest non-linear dependencies on both of these parameters. Clear dependencies of permeability on hydration level or the fraction of charged lipids, cholesterol, or POPE in the membrane were not observed (Fig. ).