The second most common neurological disorder which is affecting over 4 to 6 million people worldwide ia Parkinson's Disease . The disease is highly characterized by oxidative stress, increased lipid peroxidation and mitochondrial dysfunction . To study and observe the nature of P.D., the human neuroblastoma SH-SY5Y cell line has been used mainly in neuroscience studies. Derived initially as subclone of the neuroblastoma cell line SK-N-SH, SH-SY5Y, and these cells also share biochemical and functional characteristics in various ways .