It is suggested in Ref. 1 that the requisite number of SCF cycles is likely to increase with molecular size. This may be true in principle, given that the energy gradient with respect to orbital rotations (FP -PF) is size-extensive, but in practice this seems not to be an issue in molecules with up to ∼ 100 atoms, provided that appropriate thresholds are used. Setting τ thresh = 10 -12 a.u., DFT/def2-TZVPD calculations on C 41 H 50 O 6 N 4 converge in 14-15 SCF iterations for τ SCF = 10 -8 E h , or 7-8 iterations if τ SCF = 10 -5 E h . These are typical values even for small molecules. Similar behavior as a function of τ thresh is observed for the coronene dimer, (C 24 H 12 ) 2 . For a 157-atom DNA intercalation complex that has become a standard benchmark for noncovalent interactions, and which has an overall charge of -2, we find that τ thresh must be tightened to 10 -12 a.u. for 6-311+G(2df,p) and def2-ma-TZVP, or 10 -13 a.u. for def2-TZVPD. Upon doing so, convergence is obtained in 16 SCF iterations using τ SCF = 10 -8 E h or 7-9 iterations for τ SCF = 10 -8 E h . We recommend τ thresh = 10 -12 a.u. for most applications, switching to τ thresh = 10 -14 a.u. if convergence difficulties arise.