As mentioned above, there were hundreds of alternative children, in contrast to those predicted by more traditional screening of chemical banks. Such amount of alternatives could allow to rapidly screen all the different alphafold human Kir sequences to select for those specific for each of the human Kir variants. Additionally, large numbers of candidates could be used to extract those computationally recognizing known mutations, molecular target variations, and/or off-targets, etc. Something similar was employed with other protein /ligand pair examples for instance to select anticoagulants affecting both rats and their resistant mutants but not humans or monkeypox Tecovirimat-resistant variants .