In summary we have developed grafted multivalent coiled-coil peptides for the selective inhibition of the anti-apoptotic cancer protein MCL-1, which can potentially serve as therapeutic PPI inhibitors. For the future, our study indicates that grafting and multivalent coiled-coil strategies might be most effective using dimeric scaffolds. Nonetheless, this offers the prospect of designing homo-and heterodimeric coiled coils that recruit two copies of one protein target or two different proteins, for example a target and effector to act as "molecular glues" for proximityinduced pharmacology.