activated, namely keratinocytes, dermal fibroblasts and cells of the immune system, including neutrophils, lymphocytes, and mast . From a biological and clinical point of view, the critical stage of wound healing is the closure of the epithelial gap, primarily associated with forming an epidermis (epithelialization) on the entire surface of the wound, and the reconstruction of the wound dermis . Skin repair is regulated and stimulated by growth factors, cytokines and the extracellular matrix, but the process, despite its complexity, cannot restore skin to the state it was in prior to injury .