The results described here, identified one new chemotype predicting exceptionally low docking-score ranges with high specificity while conserving its targeting to the inner-cavity of the trimer α-helices of Omicron variants. The results remain to be confirmed after chemical synthesis (perhaps similar to those recently reported would allow experimental validation. The TTT-children were generated from the TTT parent (Figure ). The 4076-and 9990 TTT-children top-lead chemotypes were chosen as parents for additional evolutions. Six 9990-children were selected as top-leads (lower part of the Table ). Each of the child numbers were automatically assigned by the DW generation order during the 9990 evolutionary docking. Added note. Targeting the fusion-competent one-up Omicron 7to4 model inner-cavity , increased to 150-490 nM (500-1000-fold) the corresponding ADV binding-scores predicted and the docked top-lead complexes were displaced from the center to one of the sides of the inner-cavity.