For instance, some systems, such as proteins, are just too big; others have such low solubility that simulating crystallization directly from monomers in solution at experimental concentrations requires system' sizes that are simply beyond our reach (hence, the necessity to develop increasingly accurate coarse-grained representations of these systems). However, with continued advances in simulation techniques and an increased understanding of the factors that govern nucleation from solution, we believe that the next step will be to systematically extend nucleation studies to systems where the growth units are conformationally flexible organic molecules. In turn, this will enable accounting for crucial out-of-equilibrium effects in computationally-assisted material design.