This study adopted motif search, and molecular docking methods to study the SARS-CoV-2 virus protein. The results showed ORF7a had the domains of ABC transporter: ATP binding domain and transmembrane domain. The ABC transport domain of ORF7a transported molecules such as metal ions, heme, and had a multi-drug efflux function. ORF7a also has lipopolysaccharide synthesized domains. The extracellular ORF7a with the N-terminus and C-terminus cut off still has the BPI11/LBP domain (CELYHYQECVR) and two ATP-binding motifs ("HYQEC" and "TYEGNS"). Extracellular ORF7a can bind to CD14 molecules like LBP.