For each of these conformations, we draw the amine bound diagonally across the ab-plane and vertically, or columnbound, along the c-axis. See Figure . The S-shaped, diagonally bound motif is known to be the ground-state configuration, as reported in . While this known ground-state conformation looks somewhat perplexing and could be considered difficult to guess, the metal node-node distance in the unit cell of Zn 2 (dobpdc) in the ab-plane is known to be about 10.4 Å, which aligns well with the 8.5 Å separation of the primary amines in norspermine. Indeed, performing a conformer search with Spartan 66 and constraining the terminal amine distance will discover the S-shaped configuration. Drawing a hypothetical functional- ized motif with unknown crystallographic structure is difficult, and knowledge of the base framework and amine must be incorporated.