Although the cited examples have shown some applica7ons of DCvC in the context of lipid membranes or ion transport, to the best of our knowledge, controlling the transmembrane transport of ions by employing dynamic covalent chemistry (DCvC) within lipid bilayers has not yet been demonstrated. One of the challenges to be overcome has been the need for a dynamic covalent func7onal group that is sufficiently stable in the lipid/aqueous environment, while at the same 7me achieving an exchange equilibrium within the 7mescale on which the stability of the liposomes can be ensured. While imines showed very rapid hydrolysis in membrane environments and the exchange rate of acylhydrazones was too slow for our purposes, we recently discovered that azines can be used as a func7onal group in DCvC. Azines showed good stability in the presence of water and fast exchange (< 1h) in the presence of acid as catalyst. Here we show that DCvC of azines can be used within lipid bilayers to ac7vate and tune the transmembrane transport of chloride by synthe7c receptors.