In the present work, we search for simply synthesizable small-molecule NO photodonors with intense absorption in visible region. Several BODIPY-based NO photodonors have been already reported, as mentioned above. We have previously studied several hindered nitrobenzenes, linked to the BODIPY core in meso-position , but the NO release was undetectable. Mesomethylene BODIPYs have especially remarkable properties and have been used in various applications, including photolabile protecting groups . We hypothesized that this scaffold could be superior as light-harvesting moiety for N-Nitroso NO photodonors.