As an extreme example case, we also attempt to generate a mapping from a full protein mutation transformation of ASP to TYR in TYK2 with 9349 atoms. Here Kartograf solved a mapping within 2 s, whilst the SIS-based algorithms were unable to converge to a solution within a 4 h limit (See Table ). It is noted that the Lomap approaches with the iso-morphic graph search, were designed with small molecules in mind.