Understanding the degradation profile of biomaterials is crucial for optimizing their performance and tailoring their application to specific clinical needs . Degradation characteristics influence important parameters, including the release kinetics of encapsulated therapeutics, scaffold integrity, cellular behavior, and ultimately, tissue regeneration outcomes . Therefore, a comprehensive investigation into the degradation profiles of polymer hybrids containing hydrophobic macromonomer, and hydrophilic PEGylated fibrinogen and methacrylated L-DOPA is essential to uncover their full potential for biomedical applications. amines can be also well observed in the range from 1250 to 1020 cm -1 . Therefore, the differences observed in this region confirm the hydrolysis of polyurethane into amine.