On average, the PLIFs generated from DiffDock-L poses were less similar to those derived from the measured protein-ligand complexes than the PLIFs generated from Vina poses (Table ). DiffDock-L produced at least one pose with high PLIF similarity to one or more measured protein-ligand complexes for 22% of the active compounds (of each target), while for Vina, this value was 30%. A PLIF similarity of 1.00 was observed with DiffDock-L and Vina for 5% and 7% of the active compounds, respectively.