In general a low overlap does not necessarily correspond to a high error: the Pearson correlation factors for the FPA overlap vs MAE is only -0.11. While the direct correlation is small there is a modest enrichment of low error predictions for molecules with high overlap (Figure ). For example, the MAE of molecules with overlaps between 0.8 and 1.0 is 0.55 while the MAE for molecules with negative overlaps is 0.82 Figure : The bits that make the largest contributions to the predicted logP value of molecule 3. Blue circle: central atom, yellow circle: aromatic atom, grey circle: aliphatic ring atom, star/light gray bond: atom/bond not directly part of the fragment but affecting connectivity.