BLI measurements were performed as described before. Purchased analogues of the fragment hits (Table ) were measured in concentrations reaching from 2000 to 3.9 µM, merged compounds (Table ) from 2000 to 15.6 µM and the synthesized compounds (Table ) from 2500 to 4.9 µM with association 30-45 s, disassociation 60 s, and baseline 30 s steps. KD values were determined as the average of three experiments for compound 120, 122 and 124 and two experiments for 118 and 123. Reported errors are standard errors.