The right panel of Figure presents the hydrate distributions of the pyruvic acidcontaining clusters. Generally, we observe the highly hydrated clusters to be favored when the binding free energy is very negative and we observe the (PA) 1 (Na + ) 1 (w) 0-5 clusters to favor hydration the most. Similar conclusion is reached when studying the hydrate distributions obtained at 273.15 K and 258.15 K and at 50% relative humidity (available in the Supporting Information).