New small molecule inhibitors with novel chemical scaffolds and potent inhibition are required. Herein, using a knowledge-based approach, we identified two 7-aminoalkoxy-quinazolines: 12 and 13, with nanomolar inhibition of DNMT1 in enzymatic inhibition assays (30 y 80 nM, respectively). Notably, both compounds showed better inhibitory activity than the positive control, SAH (340 μM). Both molecules showed less inhibition of DNM3A (4.87 and 14.69 μM), and none of them inhibited DNMT3B.