1. This could be due to the 4PA branch containing intermediates that are more similar to the target, compared to the branch from BPA. One of the routes that was similar to the benchmark route is shown in Fig. . The exactly same route was not found because of the difference in definition of "single step reaction" among research groups. For example, steps 6 and 7 in the benchmark route, Fig. , were considered as a single step in step 8 of the route shown in Fig. . Most "single step" reactions are actually "one pot" reactions. Nevertheless, comparing the identified route, Fig. , and the reported route, Fig. , one can conclude that synthetic strategies of both were very close. Fig. . An example of routes found through 12-steps search; this route is similar to the one reported in patent, see Fig. .