To further explore possible improvements of docking affinities to 24C, larger numbers of 24L-derived fitted-children were generated by DWBEL. Results showed that despite the higher numbers generated by 6 DWBEL runs compared to 2 runs (Supplementary Materials / 6970CSP.dwar and 1301CSP.dwar), the fitted-children predicted similar affinity rank profiles with maximal affinities at low nanoMolar ranges (Figure , red circles and black-edged red circles).