The dependence of the anoxic reaction rate on the thiol and radical initiator concentrations showed that the catalytic TON of the reaction reached 2.5×10 3 after optimization (Fig. and Table ), with an initial turnover frequency (TOF) of 1.1 s -1 . Although the TOF was one order of magnitude smaller than that of the enzymatic reactions, the catalytic TON and TOF are higher than those of other radical systems (Table ), including Br -/S2O8 2- at higher reaction temperatures. This shows the potential of the current thiyl systems at lower reaction temperatures.