A variety of heteroaryl styrenes, such as 2-vinylpyridine, 2vinylpyrimidine, 2-vinylpyrazine, and the corresponding vinyl thiazole underwent the addition giving azetidines 4-7 in 55-74% yield. Reaction with substituted styrenes also worked well to provide the corresponding azetidines 8-12 in good yields. As a demonstration of the potential utility of this chemistry, we also explored the reaction with 5-vinyl thalidomide, which yielded a new E3 ubiquitin ligase recruiter building block 13 in 28% yield. More traditional Michael acceptors (methyl acrylate, methyl vinyl ketone, etc) furnished azetidines 14-20 in 47-70% yield. Reaction with CH2=CHSO2F gave product 21. To the best of our knowledge, this is the first example of preparing sulfonyl fluoride directly from non-activated amino acids. Reaction with vinyl sulfones, acrylonitrile, and a PO(OEt)2containing alkene gave the corresponding azetidines 22-26 in 29-53% yield. The MeSO2-moiety is common within approved drugs, and in this context, the MeSO2-substituted product 22 is especially interesting. The structure of sulfone 24 was proven by X-ray analysis. It is also worth noting the synthesis of P(O)Me2-substituted azetidine 27. In 2016, the FDA approved the anticancer drug Brigatinib, and since then the P(O)Me2containing building blocks have become common in medchem campaigns. Reaction with vinyl boronates gave the Bpin-substituted azetidines 28 and 29 in 34-45% yield.