Despite the progress in the fabrication and modification of synthetic vascular grafts over the years, many of these coatings have only been tested in vitro and if evaluated in animal models, have only shown promise for short-term applications. Novel strategies that exploit the regenerative biological pathways may lead to new synthetic vascular materials or/and coatings that permit vascularized, non-fibrotic tissue reconstruction. LIS coatings hold great promise as a surface modification strategy for vascular grafts, although further research on the stability and durability of the lubricant layer is necessary.