Essentially, the clustering coefficient and betweenness centrality show if (and when) the desired feedback loops are acting on the network. Fig. shows the appearance of the network measures cci and bci under a range of space velocities, sv-the parameter that determines the rate of inflow and outflow of species. The cci and bci cannot distinguish oscillations that are sustained or damped (Supplementary Information, Fig. ). To this end, we determined the intervals for their presence only for sv values within 0.02 h -1 < sv < 0.25 h -1 , the conditions wherein oscillations are sustained. We found that the trajectories of cc7 and bc5 follow the pattern of the local maxima of the oscillation in [Tr] (dashed line). Fig. shows the (dis)appearance of the connection with the intermediate inhibitor (i=5), highlighting the emergence of the reactions important for a short, or efficient, pathway in G2. In this case, the edges that are present when bc5 reached its maximum value indicate that the connections crucial for the negative feedback loop are made. Therefore, bc5 appears when the oscillation decreases. Oppositely, the clustering coefficient allows for examining the existence of the positive feedback. In the case of this CRN, it was built on three species forming a feedback loop, and Fig 5c indicates that it is present only in a narrow interval.