However, the data-rich protein targets highlighted in this section emphasised the potential relevance of hidden variant data in bioactivity modelling and were therefore the focus for the rest of the analysis. In particular, we defined a set of 13 data-rich proteins (Table ) with the highest variant bioactivity percentages (i.e. equal or above 10%) that had simultaneously sufficient data for bioactivity modelling (i.e. equal or above 1,000 bioactivity data points) and that were subsequently analysed in more detail in the following sections.