Catalyst scavenging has been demonstrated as a way to purify hyperpolarized solutions of the catalyst molecules . Using physicochemical manipulations to purify the target molecule from solution as demonstrated here has a number of notable advantages: (1) it is in principle a much faster chemical process, meaning less polarization is lost due to relaxation; (2) the target molecule can be purified of all contaminants, rather than only the catalyst molecules; (3) the dissolution solution can be chosen to yield a final solution at physiological conditions, and; (4) the pure material can be redissolved at an arbitrary concentration, up to its solubility limit, which can lead to significantly higher molar polarization in the final solution.