A key area at the center of this integration is the use of nanoporous/nanotubular structures of metal oxides, as vessels for controlled and targeted release of drugs, biomolecules, etc. . Such nanostructured materials have attracted attention due to their chemical stability , enhanced wettability , biocompatibility, mechanical robustness, and their tendency to bio-mimic the ECM (extra-cellular matrix), promoting osseointegration to name a few functionalities[ ]. In addition to a large inner volume, nanotubular structures consist of distant inner and outer surfaces that can be further modified with a range of drug molecules and proteins to elicit additional responsivity ]. These structures are particularly useful in orthopedic implant systems where both structural and chemical coating of the implant may effectively address problems of inflammation, poor osseointegration, and bacterial infection affecting implant systems[ ].