Beyond micro-CT, the methods and tools presented in this work have the tial to be valuable in other imaging and microscopy contexts where tracking grey-level change in labelled regions is desirable. The methods and GRAPES python toolkit presented here are compatible with 2D images as well as images with anisotropic pixels/voxels. Thus GRAPES is compatible with other sources of image data used to study electrochemically active particles such as optical scattering microscopy and serial sectioning scanning electron microscopy . Furthermore, we believe this method could be useful for analysing data from more advanced synchrotron imaging techniques such as X-ray Absorption Near Edge Spectroscopy (XANES) imaging and K-edge subtraction imaging, where comparing grey-level change between datasets acquired with different monochromatic beam energies implies chemical information about the sample . We anticipate that the GRAPES toolkit could have use in other fields of research. For instance, the ability to process large datasets of particles makes it suitable for fields such as catalysis, where micro-CT and advanced imaging techniques are used to study the evolving structure and chemistry of active particles . These capabilities position the GRAPES toolkit and the underlying analytical frameworks demonstrated here as useful tools for tackling challenges in imaging and microscopy across scientific disciplines. two triple-layered aluminium pouch cell materials. The assembly was then dried for 24 hours at 80°C in a glass drying oven (B-585, BUCHI Ltd) equipped a ceramicreinforced tri-layered polyolefin separator membrane (Celgard 2325, Celgard, LLC.) and a nickel negative electrode terminal from MTI Corp. Following the drying process, the pouch was transferred to an argon-filled glove box for further assembly. Here, the lithium counter electrode from Goodfellows was positioned beneath the nickel terminal, after which two sides of the pouch were sealed using a vacuum sealing machine within the glove box. Before sealing the final edge of the pouch, an excess (200 µL) of 1.0 M lithium hexafluorophosphate in ethylene carbonate ethyl methyl carbonate with 2% by weight of vinylene carbonate additive (1.0 M LiPF6 in EC:EMC (3:7 v/v) + 2% VC, Soulbrain MI) was added. The pouch cell was left undisturbed for 24 hours to allow proper wetting of the electrodes by the electrolyte. Some gentle massaging of the cell was necessary during this time to aid in the distribution of the electrolyte.