(Sunnyvale, CA, USA). Nanoparticle Tracking Analysis was performed with NanoSight NS300 using 3.2 Dev Build 3.2.16 software (Malvern Instruments Ltd, Malvern, United Kingdom). Antibody Aptamer Conjugates were purified using proFIRE instrument (Dynamic Biosensors GmbH, Munchen, Germany). Spectrophotometric characterizations were performed with Multiskan SkyHigh instrument from Thermo Scientific. Silica-Coated Gold Nanoparticles with an outer silica shell of 3 nm, were purchased from CD Bioparticles (Shirley, NY, USA). Gold nanoparticles of 40 nm of diameters were purchased from DCN (Carlsbad, CA, USA). Sample containing gold nanoparticles were sonicated using Omni Ruptor 250-Watt Ultrasonic Cell Disruptor (OMNI International, GA, USA).