We report here some limited first attempts to generate large amounts of alternative ligands to Tecovirimat by DWBEL co-evolution in Alphafold modeled F13L pooled resistant mutants. The successful targeting of DWBEL to hypothetical Tecovirimat-resistant mutant cavities by co-evolution and blind-docking, required both high computer memories to apply toxicity risk assessments and specificity (molecular weight and hydrophobicity) to control their tendencies to increase during docking . The accuracy of the predictions was improved by preserving 2D geometries to select for DWBEL consensus with AutoDockVina (ADV), recently identified as one of the most successful docking predictors .