Potassium is required for the enveloped RNA virus spikes protein to undergo conformational modifications when fusion . Dengue virus capsid protein binding to liver lipid droplets (LD) is potassium ion-dependent and is mediated by LD surface proteins . Dengue fever virus (DENV) capsid protein (C) interacts with very-low-density lipoprotein (VLDL),exploiting the cell's high potassium content . It is not with low-density lipoprotein (LDL). This contact is potassium-dependent and involves the DENV C N-terminal region, similar to the DENV C-lipid droplet (LDs) interaction previously discovered . The production of DENV lipid virus particles may be the ideal vehicle for releasing the new virus into the extracellular environment. The viruses are ultimately reaching the new target cell. Infection with the Bunya virus is also prevented by modulating potassium channels . Bunia virus infection via the envelope requires an increased potassium ion concentration [K + ]. The mechanism of virus transport via mature endosomes is regulated by the cell's K + channel(39). K + channel blockers limit Hazara virus (HAZV) infection, suggesting the K + channel as a potential anti-bunia mechanism. When type 1 immunodeficiency virus (HIV-1) infects CD4 + cells, the intracellular potassium (K + ) concentration increases . A low K + medium limits the production of HIV-1 proteins, whereas a high K + medium promotes the synthesis of HIV-1 proteins . Before hemolysis of Newcastle disease virus (NDV) , potassium is rapidly released from the cell, increasing the cell's cation permeability, then cell swelling and lysis . Potassium may play a role in the Ebola virus protein's conformational structural alterations. The unusual tissue bleeding or spurting symptoms observed in Ebola patients. It may be due to cell enlargement and lysis produced by an osmotic pressure imbalance of the K + cation.