We believe this work proposes a ground-breaking approach to protein sequencing since the aminoacid recognition depends on three orthogonal properties (the proton affinity, the dielectric constant and the length of the AAs) different in all the AAs that can be measurable with any FET with two combined measurable quantities (Ψo and CT). In particular, it is worth mentioning the perspectives of two kinds of FETs: high-K dielectric semiconductor FETs and graphene FETs. The use of High-K dielectrics in the interface gives better chances to measure because it improves the capacitance coupling of Ψo with the output current, improving the fidelity of to the surface potential and decreasing the noise. Furthermore, graphene biosensors can be advantageous because of the direct coupling of the surface potential with the Dirac point bringing the capacitance coupling to the quantum limit. The quantum coupling of the surface potential with the Dirac points improves also the sensitivity to resolve very few molecules approaching a single molecule, almost independently of the size of the sensor. Also, graphene is a material insensitive to pH , which avoids the interference described in our article. Novel approaches and the revival of classical techniques of solid phase degradation of peptides together with the advance of microfluidic techniques to manipulate minimal quantities of peptides, open perspectives to improve the current state-of-theart of protein sequencing.