The biocompatible MOFs, MOF-177 and CaBDC, demonstrated the ability to immobilize GUVs formed with negatively charged lipid mixture at 2 hours (Fig. ) and for a maximum duration of up to 6 hours (Figure , S20). Although these MOFs exhibited limited stability, their ability to effectively anchor GUVs within this time frame is still noticeable. The capacity of these MOFs to interact with phospholipid membranes, even temporarily, suggests their usefulness in situations where short-term anchoring is required to facilitate the controlled release of therapeutics. These results underscore the promise of leveraging MOFs like CaBDC and MOF-177 in the development of advanced drug delivery platforms, where compatibility with biological system and effective membrane binding are crucial. An interesting finding of our study was the effect of MOFs on the viability of GUVs. In control experiments where GUVs were electroformed in the absence of MOFs, the vesicles remained viable for up to 4 days when stored at 4°C. Whereas, in all cases where MOFs were included, GUVs gradually dissolved after 12 hours. This reduction in viability underscores the influence of MOFs on GUV stability, suggesting that while MOFs can effectively immobilize and interact with GUVs, they also effect membrane curvature and cause the degradation of the vesicles over time.