The incidence of all types of cancer is estimated to increase up to 2040, for all ages and sexes . Thus, more efficient measures should be tackled in prevention, diagnosis, and treatment. DNA's programmability and interactions with other molecules make it versatile and easily controlled. It has potential in tissue regeneration, disease prevention, and drug delivery. Meanwhile, the DNA origami method shows promise for designing and delivering drugs, particularly for oligonucleotide therapeutics that enable precision medicine for cancers and even rare genetic diseases. To optimize its utility, the production procedure of the DNA origami platforms should be streamlined by reducing the need for extensive purification of oligonucleotide strands. This could be achieved by reconfiguring the production method to occur intracellularly rather than via chemical synthesis.