Regarding the hydrophobicity of the compounds, they covered a wide spectrum demonstrating a logPo/w between -0.33 to 4.99. Yet, they all lied below the value of 5 which is the cut-off value for oral bioavailability according to Lipinski's rule of five. On the other hand, all the 15 compounds were poorly to moderately water soluble except for compound 10 which was predicted to be more soluble than the other 14 batzelladines.