Spt4 (cd07973) is a transcription elongation factor.The three transcription elongation factors, Spt4, Spt5, and Spt6, conserved in eukaryotes, regulate the chromatin structure and are essential for transcription. We widely recognize the general transcription elongation factors Spt4, Spt5, and Spt6 for their positive and negative regulation of transcription in critical regulatory and developmental functions.