The photoactive material platform investigated here is based on poly(ethylene glycol) diacrylate (PEGDA) and is well characterized from the tissue engineering research perspective. PEG is a synthetic material with profound tunability in chain lengths, functionalization, and architecture. PEGDA is well characterized with known biocompatibility , tunable mechanics , and rapid reaction kinetics, which allow for it to be utilized across several tissues and applications . PEGDA is also one of the most used derivatives of PEG due to its ready photopolymerization and/or Michael-Type additions through the terminal acrylate functional groups. When polymerized in water, it becomes a covalent, permanent hydrogel . Furthermore, peptide-modified crosslinking agents can be introduced to allow for proteolytic degradability to meet downstream design criteria .