Different from Doyle et al.'s model that used 120 descriptors as input, our model only needs 13 descriptors (Figure ) in this HTE scenario. Also, compared to the previous fingerprint-based MFF or DL-based rxnfp methods, 17, Reaxtica not only shows satisfactory performances on most of the test sets (Table ), but also displays better robustness (average test set R 2 = 0.75).