Table . Tensin related domains and motifs of E protein We obtained the Andes and Hantaan protein sequences from the Uniprot database for this work. This collection contains complete sequences for the membrane glycoprotein Envelope E, RNA polymerase L, and nucleocapsid protein N. As a result, I investigated whether these three proteins possess PTEN action. Tensin-related sequences were acquired from the Uniprot database. Then, using the local MEME tool, the Hantavirus proteins were compared to the Tensin-related proteins to identify conserved domains. Due to many motif fragments, we had combined motif fragments according to protein and domain. This approach was used to analyze both the Andes and Hantaan viruses. According to the search findings, E, L, and N contain C2 and lipid phosphatase motif fragments. However, only the E motif fragment contains Tensin-related sequences that match the "HCXXGXXR" motif. The PTEN structure of E is active based on the facts.