Schneider et al. generated a negative PDMS mold by casting PDMS on an SU-8 coated silicon wafer. They used this negative PDMS mold to produce an epoxy-based master mold for creating microfluidic channels made of TPE/PC using hot embossing approach . with permission from ACS. (e) Silicon mold with photoresist patterns and plexiglass frame. The setup was used to cast PDMS master molds for hot embossing COC and creating microchannels. Reprinted from Ref. with permission from Elsevier.