The G4MP2 energies used for this study were calculated in the gas phase at zero kelvin, which may not be reflective of the chemical environment at various synthetic conditions. Solvation effects, for example, could substantially alter a molecule's predicted stability and reactivity. Additionally, certain molecules may demonstrate enhanced stability as dimers or larger clusters, rather than monomers, primarily due to noncovalent intermolecular interactions that play a crucial role in their stability. E min does not capture this effect, as it is solely based on quantum mechanical evaluations of monomers, leaving out the potential impact of dimer formation on stability.