The following examples are studies focused on designing vaccines against Middle East respiratory syndrome (MERS) , Hepatitis C virus (HCV) , human immunodeficiency virus (HIV) , Neo-Coronavirus (NeoCoV) , Human cytomegalovirus (HCMV) , Kaposi Sarcoma 90 , as well as infections like dengue , chikungunya or those caused by Taenia solium , Klebsiella oxytoca , Klebsiella pneumoniae or Mycobacterium tuberculosis . What is also worth mentioning in the context of next-generation vaccine design is the potential use of TLR agonists as vaccine adjuvants. Since TLR agonists are capable of stimulating innate immune responses, which also trigger adaptive immune responses, they can likewise be used to improve vaccine efficacy .