It is part of a group of proteins called the initiator rep protein (IPR046828). These proteins are very important for the actinomycete integration and conjugation elements (AICEs). This family includes the replication initiator protein from Streptomyces (RepSA), which is essential for the replication of pSAM2. Origin recognition complex subunit 5 C-terminal (IPR047088) ORC1-6 encodes the six-subunit ATP-dependent DNA-binding complex known as the origin recognition complex (ORC). ORC binds chromatin at replication origins throughout the cell cycle, making it a fundamental component of eukaryotic DNA replication. ORC is essential for DNA replication initiation and is responsible for its direction throughout the genome. In order to acquire a replication license for chromosomes before DNA synthesis during the S phase, pre-RC assembly is necessary during G1.