To evaluate whether the mixed fine-tuned model could extrapolate to unknown systems, we extracted 1.5k heterocycle ring-forming reactions from 47 papers published in 2022 (here referred to as Recent dataset). While the model was, unsurprisingly, unable to predict the exact reported reactions, it provided chemically valid ring-breaking predictions for 30.4% of the molecules. This indicates that while the reported reactions are new, potentially more efficient or greener routes than those reported already, many of the heterocycles formed were already synthetically accessible (Figure ). Interestingly, the routes suggested by our model often resembled the ground truth (6Ai.-iii.). For example, both the mixed fine-tuned model and literature suggested the same Friedländer synthesis for quinoline (Figure .).