In conclusion, our study shows the potential of generative chemistry towards the development of novel antimalarials. Application of the JAEGER approach to other disease areas is relatively straightforward and is currently being explored. Further work also involves the modeling of multiple assays as well as ADME parameters to ensure off-target activities and pharmacokinetic parameters are explicitly accounted for. Algorithmic developments to improve computation time are also planned. Lgraph for tree reconstruction and graph assembly cross-entropy errors as defined in 16 , 2)