A cross-linking strategy was further included to (i) stabilise the nanocarrier, (ii) avoiding premature release of cargo, and (iii) incorporating stimuli-responsiveness. This additional cross-linking strategy serves as an additional trigger besides temperature for cargo release, through degradation of the responsive cross-links. These are important considerations when taking into account the immensely complex environment faced by nanocarriers upon in vivo administration. We employed a copper-catalysed azide-alkyne cycloaddition (CuAAC) crosslinking strategy, which remains one of the most popular "click" reactions for cross-linking and functionalisation in the biomaterial and biomedical fields due to high efficiency, specificity, and simplicity, to incorporate the necessary functional handles. Our covalent cross-linking strategy provided the fundamental advantage of keeping our nanogels intact above and below the LCST, which in turn allows fast and simple loading of cargo and subsequent purification.