The interest in the development of metal complexes for medicinal applications increased in the middle of the 20 th century after the discovery of the anticancer properties of cisplatin . Metal-based drugs are attractive due to their great versatility in terms of metal center, oxidation state, coordination number, in addition to the nature and geometric orientation of the ligands . As the use of platinumbased drugs is limited due to shortcomings as the occurrence of chemoresistance and side effects associated to their high toxicity , this encouraged the research of compounds based on other metals as alternative to platinum anticancer therapeutics , . Parallel investigations aimed to enlarge the purpose of metal complexes with the identification of additional pharmacological properties, such as antibiotic and antiparasitic .