In this technique of preparing Curcumin nanoparticle, a polymer is dissolved in an organic solvent like acetonitrile or ethyl acetate and the suspension of Curcumin is carried out directly in polymeric solution after which it is allowed to homogenise properly. Through centrifugation Curcumin nanoparticles are collected. This procedure can be briefly explained as firstly starting material in this case Curcuminoids are extracted from turmeric and are used as active compounds. These Curcuminoid compounds are unstable under heat, light and oxidative conditions and they have poor water solubility Chitosan which is a natural polysaccharide with good biocompatibility and film firming properties with Gelatine B which is a protein that exhibits excellent binding properties are used togethers to encapsulate the Curcuminoids. Coacervation process is carried out in which the Chitosan and Gelatine B interact, forming microdroplets around the Curcuminoids forming a protective matrix. Crosslinking agents such as Glutaraldehyde for Gelatine B or TPP for Chitosan are added to stabilize the nanoparticles. After which allow the reaction to proceed for a specific duration of time under continuous stirring. Separate and collect the nanoparticle by centrifugation at high speed 10600 rpm. There after give the nanoparticle washing of distilled water or ethanol so that the unreacted material is removed. Lastly the separated Curcumin nanoparticles are freeze dried to remove water by sublimation after which the Curcumin nanoparticles are obtained.