We employed the domain search method to determine that the Zika virus glycoprotein E has an NGF domain in this present study. E's NGF domain interacts with the TrkA endosome, promoting the fusion of the E and Axl receptors. The E/TrkA complex enhances Zika virus endocytosis via clathrin. Zika virus is delivered retrogradely to neuronal cell bodies via Rab5-mediated NGF/TrkA-like endosomal signals. E and TrkA separate during Rab7-mediated degradation of positive late NGF/TrkA-like endosomes. Through membrane fusion, the Zika virus is delivered into neuronal cell bodies.