The half-lives of 32,421 acyclic alkanes -all structural isomers up to C 17 H 36 -were simulated with Cantera, based on their depth-wise pruned networks (See section 1.3 of the SI). Although the absolute accuracy of these half-lives aren't at issue in the current study, it is still necessary to establish that qualitatively correct stability trends are reflected in the data for later testing of whether various ML architectures can generalize the implicit stability trends. Experimental kinetic data compiled by Sundaram and Froment for the pyrolysis of ethane, propane, n-butane, iso-butane provide several points of comparison (Fig. ). This data was used to replace the quantum chemistry based reaction data in the pyrolysis networks of ethane, propane, n-butane, and iso-butane (See Section 3 of the SI) to resimulate the half-life for comparison with the purely computational results (Fig. ). Both the experimental and simulated half-lives recapitulate established trends that increasing alkane length (comparing ethane, propane, and n-butane) and branching (comparing n-butane and iso-butane) reduce half-lives. Additionally, sensitivity analysis was performed on both the experimental and computational kinetic data with 1000 simulations done for each reaction network where random uncertainties from a normal distribution centered at zero and standard deviation of 3 kcal/mol were introduced in all activation barriers. The overlapping shaded region in Fig. imply that the experimental and computational half lives are within this uncertainty range.