The other major question is how droplets of root exudate form in the first place. Imagining a scenario where there is initially no root exudate droplet present, the concentration for sorgoleone in the extracellular space will be equal to the concentration inside the root hair cell where sorgoleone is synthesized. While we observe that sorgoleone will aggregate quickly in solution (Fig. ), and that the energetic difference between a blob of sorgoleone in solution and sorgoleone in the membrane is small (Fig. ), we also see that sorgoleone droplets may reinsert into the membrane. Naturally, reinsertion needs to be avoided somehow, otherwise sorgoleone will never make it into the soil and carry out its allelochemical function. One can imagine that large droplets may have sufficient cohesive forces or that specific lipid moieties on the outer surface of sorghum root hairs may prevent reinsertion. Alternatively, specially shaped proteins or other structures, such as perhaps a lipophilic spire, may facilitate exudate droplet formation and act to prevent reinsertion (Fig. ). Yet another possibility is that while single sorgoleone molecules can traverse the plant cell wall in the root tips, the droplet would be prevented from returning to the plasma membrane.