Structurally, they are classified into three main categories; type I involving the majority of reported lamellarins and process a fused fully substituted central pyrrolic moiety of 14phenyl-6H- benzopyrano pyrrolo[2,1-a]isoquinoline ring system. Type II bears a simpler non fused trisubstituted pyrrole of 3,4-diarylpyrrole-2-carboxylate ring system. Type III are some water-soluble sulphated derivatives of type I fused lamellarins. Biomimetically, lamellarins pyrrolic alkaloids could be biosynthetically derived from a sequential enzymatic transformation of aromatic amino acids like tyrosine and 3,4-dihydroxyphenylalanine (Figure ) . Pharmacologically, lamellarins pyrrole alkaloids (LPAs) displayed a myriad of intriguing powerful biomedical potentialities including, cytotoxicity and topoisomerase I-mediated DNA cleavage antitumor activities , mitochondrial function inhibitors ,