To increase the affinity accuracies, the DWBEL non-toxic fitted-children were ADV docked using 45x45x45 Å grids centered to the PyMol centerofmass of Vif8 and star30. The smaller and re-centered grids restricted the docking search to those conformers targeting the Vif red sA3G cavities. Compared by an arbitrary 46 nM threshold, the results predicted the highest affinities for 38.0 and 58.8 % of the Vif8-and star30-derivatives, respectively (Table ).