Curcumin loaded nanoparticles were prepared by using Single emulsion Solvent evaporation technique. In this method PLGA [Poly (lacticco-glycolic acid)], Curcumin which is active drug, Dichloromethane (DMC) and Polyvinyl alcohol (PVA) are employed to create Curcumin nanoparticles with potential application in drug delivery systems. Initially, 100-200 mg of PLGA polymer was dissolved in 5ml of Dichloromethane (DCM). Following this 10 or 20 mg of Curcumin powder was added to the polymer solution. This combination was then subjected to intermittent vortexing for over 30 minutes that ensures thorough mixing. Vortexing ensures that the hydrophobic Curcumin is dispersed with the organic phase, this is vital for encapsulation efficiency. Viscosity and concentration of the drug component does affect the duration. The prepared mixture was subsequently added to 10ml of aqueous PVA solution in a glass tube. Further this blend was mixed vortex for 10 seconds at high speed. In order to achieve emulsification, the resulting mixture was treated with a probe sonicator at 40% amplitude for 7 minutes while being cooled in an ice bath. By sonication we are able to reduce the droplet size, that directly influences the final particle size of the nanoparticle. Ensuring the sonication parameters such as intensity and duration are as per the parameters is very important to prevent over heating which might degrade Curcumin. After emulsification the solution was transferred into 30ml of a 0.5% aqueous PVA solution which is then stirred magnetically. To remove DCM the emulsion was subjected to high-speed magnetic stirring at 800 rpm for 3 hours leaving behind nanoparticles stabilized by PVA. A closed system with controlled evaporation may improve reproducibility. Further the nanoparticles were isolated by centrifuging at 20,000 rpm for 15 minutes. High speed centrifugation effectively separates the nanoparticles from the aqueous medium. Proper care must be taken to prevent aggregation due to high centrifugal force. However, if aggregation occurs adjust the centrifugation speed or add surfactants. The nanoparticles were washed three times using distilled water to eliminate residual components which might otherwise affect the biocompatibility. Finally, the nanoparticles pellets were resuspended in 5 ml. of distilled water.