Chen et al. performed a structure-based VS of the ZINC database. Based on the scoring results, including shape, chemical-feature, and drug-like properties, they identified potential agonists targeting the TLR2 heterodimer and modulating the TLR2/1 response. For the most promising candidates, which shared a motif of an amine conjugated with an acid substituent, they tested their activity in vitro. The results revealed that two compounds showed a high TLR2 activation effect and that one compound -ZINC6662436 (SMU127) -stimulated the NF-κB) B and promoted tumour necrosis factor-α in human macrophage and mononuclear cells. Also, the in vivo results