The effective volume of any CG particle 𝑖 can be calculated from two representations, CG and AA. For the CG representation, the calculation of effective volume 𝕍 𝑖(𝑃) 𝐶𝐺 is completely identical to eq.( ). For the AA representation, the effective volume 𝕍 𝑖(𝑃) 𝐴𝐴 can be calculated by numerically integrating the elementary volume encircled by the zero-potential surface. A faster approach is to compute the radius of all spherical zero-potential surfaces for all AA members and take the volume encircled by their unions. These two approaches are named as EX1 and EX2, respectively. The repulsive volumes calculated by EX1 and EX2 are given by eq.( ) and eq.( )