To explore the structure electroactive relationships (SeAR) between the PTZ analogues represented by 2-CPTZ and CPZ, we sought to develop a modular synthesis of R1 and R2 point variables during a related medchem campaign (Scheme 2). Scheme 2. General synthesis of novel PTZ containing structures to explore linker length and amine effect. Summary of initial oxidation potentials observed in PTZ analogues derived from cyclic voltammetry measurements.