The optimization scripts of HiMap were modified to print the eigenvalues of the Fisher information matrices by using the R eigen function. The input weights chosen that were held constant were the first twenty lexicographically ordered ligands of the representative congeneric series analyzed in Fig. . We generated designs and calculated eigenvalues in triplicate for each combination of 𝑛 and 𝑘. We plotted continuous distributions based on the sampled data using kernel density estimation. The code for generating plots is eigen_val_hists.py and the raw data is jdata_n_20.txt .