Thus, the nanobubble structure becomes unstable, and one would obtain a micellelike structure. Above, we distinguish two different situations, both leading to compressed amphiphile monolayers that can stabilize bulk nanobubbles. However, they applied to different situations. For the first one, the one-component rigid monolayer model, it may apply to systems with insoluble surfactants of a single type (e.g., lipid). In this case, the bulk size is mainly controlled by the spontaneous radius of curvature, 𝑅 , which is directly related to the shape of an amphiphilic molecule (the packing parameter of amphiphilic molecules). For trace organic contaminant-stabilized bulk nanobubble systems, for which most bulk nanobubbles are experimentally reported, we prefer the second situation, i.e., the multi-component soft monolayer. In this model, the multicomponent monolayer is featured with a lower bending constant. Under the condition of 𝜅~ 𝑘 𝑇, at which thermal and bending energy are of comparable contributions, the persistence length 𝜉 or bubble size would have a size around 100nm. In case of 𝜅 ≪ 1𝑘 𝑇 the nanobubbles would become unstable and micelle-like structures are preferred.