CSP typically relies on an exploration for the local energy minima on the high-dimensional energy surface as a function of the structural variables that determine the packing of a molecule into a crystal . The structures corresponding to each local energy minimum are usually considered as possible polymorphs, with the assumption that the lowest energy predicted structures correspond to the most likely candidates to be observed experimentally. One limitation of the output of such methods is that, while they provide the geometry and energy of each potential structure, no information is gained about the depth of each energy minimum, nor possible transition paths and energy barriers between structures. This is currently a limiting factor in the analysis of the results of CSP.