The long-term goal of the project is to collect, unify, and standardize the Latin American NP collections available in the public domain into one public database. In this study, we report significant advances towards this goal by the assembly of the first version of the unified database herein called Latin American Natural Products Database (LANaPD). We report its curation, standardization, and a comprehensive analysis of nine compound databases, totaling 12,959 unique molecules. As part of this study, analyzed the structural content (scaffolds and ring systems), structural diversity, and complexity of the compounds in LANaPD. We also represent coverage in the chemical space of compounds in LANaPD using the concept of chemical multiverse .