As evidenced in Appendix A.1.2, SynTemp exhibited superior robustness compared to CGRTools 24 in AAMs comparison. We then utilized SynTemp to integrate state-of-the-art tools utilizing partial ITS graphs comparison to refine the accuracy and reliability of AAMs. This evaluation involved an assessment of four state-of-the-art tools (RXNMapper 0.3.0, GraphormerMapper 1.75, LocalMapper 0.1.4, and RDTool 2.4.1) alongside two ensemble strategies, applied across five distinct datasets. For technical details on the benchmarking procedure and the choice of tools, we refer to Appendix A.1. The results are summarized in Figure .