Among the engines, Auto3D and CREST had the capability to perform clustering as part of their conformation generation process, whereas Balloon and ETKDG did not include this clustering step. Consequently, after generating conformations using Balloon and ETKDG, we applied the Autograph clustering algorithm to cluster the resulting conformational ensemble. This allowed for an analysis of the conformations and their subsequent evaluation in terms of capturing the global minima. The number of conformations generated by Balloon and ETKDG prior to the clustering step can be found in Table -S64 in the SI. The inclusion of a clustering step in Auto3D and CREST eliminated high energy conformations giving a short list of conformations to consider. On the other hand, Balloon and ETKDG produced a significantly higher number of conformations due to the lack of this pruning step. It is worth noting that the number of conformations generated by Balloon was lower than that of ETKDG.