The Synthetic Accessibility Score (SAscore) is a metric used to evaluate how easily a drug-like molecule can be synthesized. It rates molecules on a scale from 1 to 10, with the score based on historical synthetic data and molecular complexity. The score is determined by considering fragment contributions and applying a complexity penalty, using data derived from PubChem's extensive molecule database. The SAscore has been validated against expert chemists' estimations, showing a strong correlation (r2 = 0.89). This method leverages big data to streamline and enhance the process of assessing the synthetic feasibility of molecules in molecular design.