Determining the composition of mixtures of compounds is a common and essential task that can be challenging as the components may have similar physical and chemical properties. There are several methods for determining the composition of mixtures, including chromatography, spectroscopy, and mass spectrometry . In recent years, MicroED has emerged as a promising technique for identifying and quantifying the components of complex mixtures, offering high resolution and sensitivity. Crystallization naturally distinguishes between different isomers, including constitutional, conformational, geometric, diastereomer, and enantiomer isomers, based on their crystal structure properties . Even without solving the full crystal structure, the unit cell parameters and space group can describe the crystal structure and its content. This means that most compounds can be distinguished by their unit cells, making compositional analysis of crystalline samples possible without collecting a full set of crystallographic data. Since determining the unit cell parameters is one of the first steps in structure determination and does not depend on solving the phase problem or collecting high-resolution data, this approach can be used even when the diffraction qualities of the compounds are limited.