Aldehydes and ketones are important intermediates in the synthesis of pharmaceutically active agents, antioxidants, agrochemicals, and fine chemicals. 2-Butanone (methyl ethyl ketone, MEK), which can be obtained by the selective oxidation of 2-butanol (2-BuOH), is typically used as a solvent, or it is employed for producing 2-ethyl hexanol, 2-ethyl hexanoic acid and polyvinyl butyral, and for manufacturing plasticizers, rubber accelerators and synthetic resins. The commercial production of MEK is typically based on the dehydrogenation of 2-BuOH over Cu and Zn catalysts (occurring under harsh reaction conditions). Some processes based on the oxidation of 2-butene and isobutyl benzene have been proposed, but they are not available on a commercial scale. However, the production of MEK through the oxidation of 2-butanol is gaining interest because it offers the opportunity to reduce the environmental impact of the production of MEK and to work in mild conditions. The oxidation of 2-BuOH to MEK has been studied involving catalysts such as Pt nanoparticles supported on γ-Al2O3 33 and Au nanoparticles. Spinel-based systems have also been studied: the maximum catalytic activity for the reaction over manganese oxide on different oxide supports was observed in alumina-and zirconia-supported catalysts, where the spinel Mn3O4 was present. Another manganese-containing spinel, MnCo2O4, was tested as a catalyst for the selective oxidation of 1-butanol to butyraldehyde; however, the process formed significant amounts of undesired acetaldehyde and propionaldehyde.