A key consideration in XRD-CT is the way in which data are treated. XRD-CT requires good, welldistributed powders so that the reconstruction is not impacted by diffraction events from single crystals. These events manifest themselves in "streak" artefacts in the reconstructed images and distort them, hence we need an approach to counter this without compromising the information in the patterns. Organic materials, including glycolide, can be poor powders with larger particles present despite significant particle size reduction through milling. Typically, this problem is addressed via a mean-trimmed filtering approach which removes values above/below a specified limit, e.g. the top and bottom 10% of diffraction intensity at any given 2ϴ value. By this approach, the significant individual spots are removed whilst, crucially, maintaining the diffraction from the rest of the powder at the same 2ϴ range. This process leads to significantly improved image quality in the reconstructions.