The objective of this study is to establish a new index for the stability of layered intercalation compounds. Considering the intercalant as the complex center and the host as the ligand, layered intercalation compounds are similar to complexes. We explored the possibility of applying discussion on the stability of complex compounds. Various quantitative formulas, including the HSAB principle, have been proposed for the determination of the stability of complex compounds. Among them, Xu et al. reported a highly quantitative regression equation eq. 2 for the reaction energy of complex compounds: 2.303𝑅𝑇 log𝐾 ML = 𝛼 * ML ∆𝐺 °f,M 𝑛+ + 𝛽 * ML 𝑟 M 𝑛+ + 𝛾 * ML ∆𝐺 °s,M 𝑛+ -𝛿 *