For compounds 9 and 13, difference electron density was found in both pockets present in the dimer while for compound 39 sufficient electron density to justify placement of a ligand was only found in one of the pockets. Common to all binding modes for the compounds in this group is a F -π interaction between the fluoroaryl of the hit compounds and the surrounding phenyl alanine residues 203 and 400. The distances between the F atom and the nearest ring carbon and the centre of the aromatic ring are ~3.2 Å and ~4.4 Å, respectively. Moreover, hit compounds 9 and 39 establish an additional hydrogen bond interaction with their carbonyl groups and the side chain oxygen of Thr271. Fragments binding in the fatty acid binding site