Given the increased nucleophilicity and flexibility of alkylamines, we hypothesized that new MOFsupported multidentate ligand scaffolds could be accessed through SN2 alkylation of 2-CH2NH2-23% (Fig. ). In particular, alkylation is a common way to achieve polypyridyl ligand scaffolds. For example, double alkylation of the amine sites in 2-CH2NH2-23% with 2-(bromomethyl)pyridine should generate tridentate bis(2-pyridylmethyl)amine ligands, also commonly known as di-(2-picolyl)amine (DPA) (Fig. ). While polypyridylamine ligands are found throughout inorganic chemistry, particularly in the study of biomimetic dicopper and diiron-oxo and dioxygen chemistry, to our knowledge no polypyridylamine complexes have been previously grafted in a metal-organic framework.