The transferability of the ML-derived offsets to related simulation protocols was also assessed to evaluate the general applicability of the methodology. Figure summarises changes in metric ranks for all complete submissions that featured an FEP methodology (n=19 A number of submissions made use of empirical correction terms that account for known deficiencies of the GAFF force field. For instance submission 005 corrects the tendency of the GAFF forcefield to underhydrate hydroxyls. This source of error has been picked up by the ML-models as evidenced by the large offsets for mannose (Figure ). Consequently applications of the offsets to submission 005 overshoots the hydration free energy of this compound, which contributes to a noticeable loss of ranks in MUE/RMSD. Submission 006 also includes an additional polarisation correction term that partially cancelled the effect of the hydroxyl correction term. The offsets restore partially the correction, leading to improved rankings. A similar behavior is observed with submission 138 that used QM derived corrections to improve GAFF hydration free energies reported in submission 137, leading to redundancy with the ML-derived offsets.