Reactions that break strong carbon-carbon bonds are of fundamental importance. For example, C-C bond activation is emerging as a fundamental transformation that can be used to achieve skeletal modification of organic molecules, offering a novel approach for synthetic disconnections. Reactions that break C-C bonds also underpin our global energy sector. Catalytic cracking of C-C bonds in hydrocarbon feedstocks, such as crude oil, converts high molecular weight alkanes to more valuable alkenes and medium-length hydrocarbons (e.g. C7 to C9 alkanes). Breaking C-C bonds is, unsurprisingly, very challenging. C-C bonds are ubiquitous but strong and non-polar. The bonding orbitals associated with C-C bonds are often sterically congested, making them kinetically inaccessible. Take for instance, the bonds found in alkanes: The C-C bond of CH3-CH3 has a homolytic bond dissociation energy of 90.1±0.1 kcal mol -1 . Chemoselectivity further complicates C-C bond activation, with surrounding C-H bonds often the first sites to react.