The types of AHAS inhibitors mentioned bind away from the catalytic site containing G511, V485, M513, and H643. This off-catalytic site binding of the 5 mentioned classes inhibitors is different than typical direct obstruction of an active site region on the surface or in the plant protein. Both types of inhibitors are observed also in therapeutics of human disease. The catalytic amino acids and the herbicide binding site are highlighted in green and red in the monomer depiction Figure .