An additional analysis was carried out on the QM/MM MD data in order to identify intermolecular DNA-protein interactions within the two G-rich QM regions. Multiple interactions were identified for region 1 systems (SI Table ). Few DNA-protein interactions were identified with respect to the G-rich region 2, despite the fact that this region of DNA remained near to the histone residues throughout the entirety of the simulation (SI Table ). This finding indicates two G-rich regions of different structural exposure within the NCP, with region 1 being more buried and region 2 being more weakly coupled to protein residues in its vicinity, and thus more exposed, respectively. This demonstrates that even local differences in intermolecular interactions within the NCP do not alter the large impact that 8oxoG has on the redox properties of NCP DNA, and thus even more strongly points to the recognition of 8oxoG in chromatin being possible via a DNA-mediated charge transfer (CT) scheme.