The molar volume of drugs and polymers obtained by YMB method was higher than HnV (Figure ). The SPs of the drug library were obtained by HnV method using equation 1 to 6 and for YMB methods, the drugs SMILES were obtained by drawing the structures in ChemDraw followed by further processing in HSPiP software. The δd, δp, δh and δT of all the drugs generally followed similar trend irrespective of method i.e. HnV or YMB with the single exception of Genistein, where δd, δh and δT were found higher in case of HnV method (Figure ). Overall, the HSPs values obtained by YMB are slightly lower than HnV, except for δp,