This computational study also highlighted an interconnected conformation in which hydrophobic Dxm molecules could coalesce at 30 °C, while a more extended conformation was obtained at 4 °C (Figure ). Such dual-sensitive polymer prodrug hydrogel was able to be retained in the synovial cavity for at least one month, enabling a sustained drug release by slow dissolution of the polymer scaffold and release of water-soluble polymer prodrugs before being processed by phagocytic synoviocytes. It has been shown to sustainably improve joint inflammation and pain in a rodent model of inflammatory arthritis and osteoarthritis.