The results obtained by normalizing the number of known products in each transformation are shown in Figure . A smaller percentage (darker blue) signifies that fewer of the generated compounds already exist, indicating more impactful skeletal edits. This analysis reveals that the pyrazole-to-furan conversion (a tandem nitrogen-to-carbon and nitrogen-to-oxygen atom transmutations) is the transformation with the greatest potential to access the largest number of unknown compounds. Other potential transformations that would be highly impactful include the pyrazole-to-pyridazine and thiazole-to-pyridazine transformations.