OM-pBAE formulations have low cell selectivity and high adsorption capacity for serum proteins leading to corona formation and systemic removal . This feature detrimentally affects their capacity to specifically target the disease sites in vivo and their selective transport across biological barriers. Several studies have explored modifying pBAEs with other polymers and lipids to achieve some degree of tissue selectivity . Most prominently, a recent study has reported the development of zwitterionic-grafted pBAEs that enable low opsonization and immunogenic response by rendering stealth properties to the pBAEs against serum protein adsorption . In this publication, the pBAE itself is used as the seed for reversible additionfragmentation chain-transfer (RAFT) polymerization. Inspired by this example, here we seek to design an alternative way that enables direct conjugation of the zwitterionic moiety without the need of an additional polymerization step.