In this study, we have demonstrated the applica on of SRS microscopy, augmented with SFG and confocal reflec on measurements, for label-free and chemically-specific imaging of fast-paced phase changes in ASDs exposed to aqueous media. We were able to (semi-)quan fy the drug, polymer and water distribu ons, both within the films and the dissolu on medium. Phase phenomena that were imaged in real me include the water penetra on front (represen ng the glass-gel interface), matrix swelling, dissolu on, bulk and surface-directed AAPS within the film (including surface enrichment of the drug), and LLPS within the dissolu on medium. These phenomena were strongly affected by drug loading. Overall, SRS microscopy with fast spectral focusing is well suited for qualita ve and quan ta ve insights into waterinduced ASD phase phenomena, with chemical, solid-state, temporal and spa al resolu on. These insights should facilitate ASD formula on development, especially since there is poten al for quan ta ve imaging of more chemically complex ASDs containing mul ple APIs and/or excipients.