As seen in Table , no C2-deuteration occurs in the absence of palladium. Selectively C3-deuterated indoles can thus be obtained in quantitative yields by treatment with CD3CO2D under palladium-free conditions (Scheme 5). The products from this palladium-free method did not require purification by column chromatography, which resulted in high C3-deuteration values (75-98%) across the board.