To probe the possibility of experimental realization of our theoretical prediction, we focus on the currently available plasmonic nano-cavity parameters for the cavity frequency and field strength. We further scanned all possible polarization directions. Interestingly, we can find finite regions in the configuration space of polar angle and azimuthal angle which make the ortho-or para-substituted species more stable than the meta-substituted intermediate, with the largest stabilization energy of 6.43 kcal/mol (11.24 k B T at room temperature) for ortho and 1.97 kcal/mol (3.42 k B T ) for para. The relative probability of forming the ortho-and para-substituted species is P ortho /P meta = exp[-(E ortho -E meta )/k B T ] = ∼7×10 5 for ortho and P para /P meta = 30 for para. This implies that with the nano-cavity, and fully isotropic orientations of the molecule inside, one should expect to generate a non-meta substituted product, demonstrating that coupling to cavity can make the non-standard product which can not be easily obtained otherwise. More importantly, we have explicitly shown that coupling to a photonic cavity will will dramatically change the selectivity. Furthermore, from an experimental perspective, detection of these anomalous products will provide conclusive evidence of the cavity-mediated effects in the ground state.