General procedure for the synthesis of alcohols 21. The substituted acetophenone was dissolved in tetrahydrofuran (20 mL) at -78 °C and 1.2 equivalent of Grignard or organolithium was added dropwise using a syringe. The resulting mixture was stirred for 1 hour at -78 °C and gradually warmed to room temperature overnight. The reaction was quenched with saturated ammonium chloride and the resulting solution was extracted with ether (3 x 20 mL). The mixture was washed with brine, the organic phase was separate, and dried with anhydrous sodium sulfate. The product was then purified using column chromatography.