We examined the overlap between the top K RF-C compounds and the top K Similarity Baseline compounds from Enamine REAL for thresholds K ranging from 50 to 100,000. The overlaps in prioritized compounds varied from 19% to 34% (Table ). These overlaps in predicted Enamine compounds are even lower than the 54% overlap the two methods had in the AMS dataset (Table ), most likely because of the much larger size of the Enamine synthesize-on-demand library. show the Tanimoto distance distributions of the inactive and active screened compounds using the initial hit criteria. Tanimoto distance is 1 -Tanimoto similarity.