Considering that there could be some metastability in the simulated transition from lamellar to the inverse hexagonal phase, we also pre-constructed inverse hexagonal phases and measured the lattice distance Dhex across different hydration levels (Figure ,C). At 295 K, Martini 3 simulations results in smaller lattices distances compared to Martini 2, which is in better agreement with experimental data . Increasing the temperature to 320K, results in a decrease in the lattice distance for 12 to 16 waters per lipid, which has also been observed experimentally .