We will also present our theoretical findings on the planning of designs. These results are integral to the features included in HiMap and should inform design decisions. For example, we show how the number of edges in a design should scale with the number of ligands to avoid accumulation of errors. To our knowledge, the question of how 𝑘 should vary with 𝑛 for alchemical designs is largely unexplored. So, we aim to provide both an accessible tool to users and theoretical insights that researchers can apply beyond the scope of HiMap.