We found it surprising that the Tanimoto similarities T (c p , c g ) were so similar within the groups A-D and F-H, despite very different language specifying how the changes should be made. This indicates that the magnitude of the variation (e.g., "similar" or "completely different") can be somewhat decoupled from the mechanism by which the modification is enforced (e.g., ". . . by tweaking only the side chains"). If it holds in general, this behavior will make LLM-driven molecular modification an extremely versatile tool for materials design in the future.