While several methods for quantification of task distance have been devised, the concept of task distance has yet to be thoroughly explored in certain scientific domains, including areas related to small molecule research and, more specifically, bioactivity prediction. In this context, a relevant question is how much information available on small molecules interacting with a protein (e.g., measured bioactivities) is transferable to another protein. Answering this question requires reliable measures of the distance between tasks, which include bio-macromolecular targets and bioactivity (drug-target interaction) datasets.