Aryl-and alkenyl-substituted alkynes were also broadly compatible with the annulation, giving a similar series of products; however, a general lower efficiency was noted for arylsubstituted alkynes, consistent with previous observations with bulky alkynes in this area. Scheme 2. Example scope of the annulation process. a Determined by 1 H NMR assay using 1,4-dinitrobenzene as an internal standard. b Using 10 mol% Pd(dppf)Cl2. c Using Pd(OAc)2 (5 mol%), NaOAc (2.5 equiv), LiCl (2 equiv), DMF, 65 ºC.