Discussion of peptide binding trends. To gain further insight regarding the selection of each preferred peptide sequence, the surface properties of the MONs were compared with those of the consensus peptide. Based on related studies, we hypothesized that three different factors could be important for binding: 1) electrostatic interactions, 2) hydrophobic interactions, 3) specific R-group interactions (Figure ). Experimental and calculated data to test the relative importance of each type of interaction are presented in Table .