03) Biosynthesis of the highly oxygenated tetracyclic core skeleton of Taxol. Yang, C., et al. The paper titled "Biosynthesis of the Highly Oxygenated Tetracyclic Core Skeleton of Taxol" presents several significant advancements in understanding the biosynthesis of paclitaxel (Taxol), specifically in elucidating the biosynthetic pathway of its complex oxygenated tetracyclic core skeleton. Here are the main advancements and findings in technical detail: