We have observed a rich variety of morphological and topological transitions in DOPC GUVs induced by MO-LCNPs in the Im3m cubic phase. These LCNPs fuse into the GUV membrane, increasing the excess membrane area and seeding the membrane with enhanced topological Gaussian curvature energy that lowers the energy barrier to the observed fission, fusion and tubulation processes. The interplay between these different morphological changes is summarised in Fig. .