Although there have been advances in the application of hydroxyapatite nanoparticles as a component in drug delivery systems, some gaps in the field need to be filled. No work was found that used hydroxyapatite nanoparticles as a drug load system for artemisinin. Additionally, no literature evaluated the role of Euclea natalensis metabolites in the surface of hydroxyapatite nanoparticles on drug load and release.