Binding to the surface of the natural born dendritic box 1 induces a structural change releasing the trapped DMF from the dendrimer, and is thus an example of a dendritic box with a key. This concept could be utilized for drug-delivery, but further investigations are needed. All organic extracts were dried over anhydrous magnesium sulphate unless otherwise stated. All yields reported refer to isolated materials judged to be homogeneous by TLC and 1 H-NMR spectroscopy, unless otherwise stated.