In this study, the researchers used BDDPEs to detect biological species (norepinephrine and serotonin) and heavy metals (Pb and Cd) using μPADs, demonstrating the potential of BDDPEs as point-of-care sensors. This study marks the first fabrication and electrochemical characterization of BDDPE for μPADs. The researchers highlighted its advantageous properties, such as a wide solvent window, low background currents, and resistance to surface fouling. Additionally, the BDDPEs can be easily fabricated and integrated with ePADs, and their cost-effectiveness makes them more amenable to disposable and portable platforms than conventional BDD electrodes. The researchers demonstrated the applicability of BDDPEs by detecting biological species and heavy metals in both ePAD and μPAD formats. For instance, the ePAD device was capable of simultaneous detection of NE and 5-HT in wide concentration ranges and with low limit of detections. The researchers overcame electrode fouling from 5-HT electrooxidation through anodic electrode treatment, enabling multiple measurements with one electrode.