Overall the quality of the pose prediction degraded mildly when we considered the binding poses after MD. The mean and the median increased from 1.32 and 1.25 Å before MD to 1.75 and 1.70 Å , respectively after MD. Although the RMSD of 9 out of the 20 poses either improved or didn't change significantly after MD, the rest of them differed by at least 0.5 Å or more. This finding is not surprising since if the starting pose in MD is not stable, it is highly likely that the ligand will try to explore around the binding pocket during the simulation to find favorable and/or metastable binding modes. Also, the proteins are crystallized at very low temperatures, whereas we use room temperature in our MD simulations. This is also a possible contributor to the higher RMSD values achieved after MD for some of the ligands -thermal motion ought to result in some change in binding mode, but additionally, the low temperature binding mode might be different (perhaps only subtly) from that at room temperature.