Table summarizes the force constants obtained from the experimentally measured ψ-and C--O angle distributions. It is important to note that fibril misalignment introduces additional uncertainty in determining the force constants for the C--O bond angles, but not the Ramachandran ψ-angles. The effect of this greater uncertainty is that the apparent force constants determined experimentally for the C--O bond angles are lower than in actuality. This means that the structural con-straints applied in the MD simulations are relaxed and allows a greater ensemble of fibril structures to be sampled in the trajectories, effectively reducing the apparent resolution of our structural models.