But the BespokeFit variant of the FF further improves all of the reported statistical measures. In particular, the correlation between the calculated and experimental binding free energy is improved from 0.72 0.87 0.35 to 0.93 0.97 0.84 and the confidence interval is significantly narrowed. These data also indicate that our choice of fragmentation scheme has generated torsion parameters that transfer well from the fragment to the parent, without introducing any irregularities into the FFs.