The mobility of all lipid molecules is also affected by their interactions with SMAC molecules, particularly, the total lipidic Mean Squared Displacement (MSD) is reduced by increasing amounts of SMAC:lipid contacts (see figure in supplementary information). In the stabilized fusion pore, the amount of SMAC:lipid contacts increases together with the radius of gyration of all SMACs (see figure S7 in supplementary information), while the ensemble average of SMAC self-interactions monotonically decreases over time (see figure S8 in supplementary information). These effects combined support the premise that establishing steady state SMAC:lipid contacts promotes SMACs to isolate and to increase their conformational exploration space.