Using the cov-only method, which considers the covalent link from the docking initialisation -similarly to AD and GOLD -, gives success rates approximately 10% higher than GOLD/PLP, while the switch method gives an even superior success rate (78%, Supporting Information, Table ). The success rate of 56% obtained with the non-cov method of AC is comparable with the ones obtained with other docking codes using their covalent docking feature. AC also shows the smallest drop in success rate between dockings starting from the native or a random conformation of the ligand (5%), as compared to GOLD (7%) and AD (14%) highlighting its good sampling capabilities (Supporting Information, Table ).