The search images as saved in MRC format were converted to TIFF format using mrc2tif software. Then the converted images were imported into ImageJ software with the Threshold values to be adjusted until the whole crystals were fully detected (colored in red, Figure ). In ImageJ, the "Analyze Particles" function was used to automatically integrate, the crystal and each outline of integration (colored in black, Figure ) was manually inspected to ensure that only the crystal area was integrated. The crystal area was calculatedSupplementary and summed for each composition (see above), as 𝑆 𝐶𝑜𝑚𝑝 and 𝑆 𝑇𝑜𝑡𝑎𝑙 for ratio analysis.