The analysis depicts mostly no variation in the orientation shift along the residence, implying that increased modulator presence in clusters affects probe orientation equally at the transition state and at the bulk of the micellar residence. This is true except for chemistries involving LAU as probe or modulator. It appears that clusters with high LAU concentrations show more pronounced tangential orientations at the transition state, which continuously diminish throughout the probe residence. This behavior could again be clarified by the increased cluster compactness induced by the lipid (Figure and). High-LAU compactness could obligate probes to more forcibly disrupt the micelle during their transition and assume more tangential orientations. These changes may explain LAU-modulated detected kinetic effects. In sum, both dynamic analyses portray changes to lipid-cluster interaction modes, suggesting that although catalytic contributions are undeniably present, accretion kinetics are more influenced by compositionally-driven affinity modifications.