Alessio iulli -Centre for Targeted Protein Degradation, School of Life Sciences, University of Dundee, Dundee DD15JJ, U.K.; orcid.org/0000-0002-8654-1670 Email: a.ciulli@dundee.ac.uk Author Contributions A.S. led the conceptualisation, design and synthesis of the compounds, performed the biological assessment, and preliminary NMR studies. C.J.D. contributed to the initial compound design and assay supervision. L.W. carried out 2D NMR studies and assignments. A.C. supervised the project. A.S. and A.C. co-conceived the study, and cowrote the manuscript with input from all co-authors. All authors have reviewed and approved the final version of the manuscript.