Induced pluripotent stem cells (iPSCs) were obtained from a PD individual carrying the LRRK2 G2019S variant. An isogenic control (IC) was engineered from the same line using CRISPR-Cas9 technology , , . Neuronal cultures enriched in midbrain dopaminergic neurons were generated following the Reinhardt et al. protocol , , details can be found in S1.4.1 and Table . At day 29, cells were treated for 24 hours with bisphenol S (BPS) (Sigma, 43034), at two different concentrations (100 µM and 500 µM), using dimethyl sulfoxide (DMSO) (Sigma, D2438) as a vehicle, before staining and imaging. Details about the mitochondrial membrane potential and mitophagy assays can be found in S1.4.2 and S1.4.3, respectively.