A t-SNE dimensionality reduction was performed in the dataset to track which molecules have higher solubilities. As seen in Figure , the DES conformed by acetylcholine chloride and imidazole showed low solubilities compared with choline chloride and ethylen glycol mixtures. Nonetheless, some DESs exhibit a high solubility, such as Triethylenglycol and Allytriphenylphosphonium bromide. The points with higher solubilities can be isolated to generate a set of suitable HBA and HBD molecules to generated novel DESs. With these powerful techniques, the search space for promising DES can be reduced to explore its industrial applicability or for future exploration with the GNN-MG model.