The input material is the substrate, and the output material is a fraction of the substrate that has been transformed or that has undergone a turnover process during the catalytic cycle to yield the product. Now the question is: how many catalytic cycles were able to transform a given fraction of the substrate polymers? What is the number of molecules of the product yielded from such transformations? Another question that arises is: does it mean that the number of substrate molecules that underwent the turnover processes is the same as the number of catalytic cycles? The answer to the third question is no. The reason is that unbinding of the enzyme substrate complex, ES, may be preceded by either deactivation of the activated ES (ES # ) or the latter proceeds to the enzyme product complex, EP, and finally dissociates into free E and P; the two scenarios are depicted as Preprint submitted to ChemRxiv, Jun 05, 2023