Loading of liposomes with hydrophobic compounds often achieves high entrapment efficiencies (>90%) in a simple thin-film hydration process . Indeed, hydrophobic compounds preferentially position themselves within the hydrophobic environment present in the liposomal bilayer. In contrast, hydrophilic molecules are easily dissolved in the aqueous phase (aqueous core of the liposomes and surrounding aqueous media). The large volume of hydration used to fabricate liposomes generally leads to low entrapment efficiencies, resulting in large discrepancies (2.1 -72%) being reported for hydrophilic peptides and proteins .