The C2 domain activated the PKC pathway when the fusion of the Hantavirus membrane with the endosomal membrane. Dephosphorylation of PtdIns P3 by the phosphatase domain inhibited the PI3K signaling pathway. Hantavirus's membrane fusion process had been shown to disrupt lipid metabolism and endothelial cell remodeling in vascular endothelial cells. It increased the permeability of the blood vessels and resulted in renal and cardiopulmonary syndromes.