The dynamic nature of the supramolecular equilibrium state, qualitatively shown in Figure , is quantitatively analysed in Figures . We e.g report the molecular traffic and flux along CG-MD (figures 2d(bottom), 2f(top), S3 S5, S7): the traffic indicates the sum of molecular binding and unbinding events (per monomer) during the CG-MD, while the flux indicates the cumulative difference between these binding and unbinding events (see Methods for details). After the equilibration stage (∼ 1 µs of CG-MD), the flux reaches a plateau while the traffic keeps increasing (see Figure ). This means that, at the equilibrium, the average size of aggregates remains stable (binding and unbinding events balance), while monomers/oligomers continuously exchange among different constructs. This manifests the intrinsically dynamic character of these systems at the equilibrium. Both S and R cases converge to the same traffic and flux profiles, indicating that they have reached the same dynamical equilibrium state.