Applications of sDFT to molecular dimers and clusters are reviewed in Sections 5.1 and 5.2, respectively. The use of FDE for modeling solvent effects on molecular properties and novel strategies for choosing the frozen electron densities of the solvent in such studies are discussed in Section 5.3. Novel developments for applying sDFT/FDE to a wide variety of bulk systems -including liquids and solids -as well as their interfaces are presented in Sections 5.4 and 5.5. For an earlier review on sDFT advances for condensed-phase systems, including aspects of excited states, dynamics, and many-body interactions, we also refer to Ref. . Applications of FDE for local impurities in bulk systems and for molecules adsorbed on surfaces are reviewed in Section 5.6. Finally, extensions for applying sDFT/FDE to biomolecules are discussed in Section 5.7.