Finally, we applied the bond-based correction method to Strecker's synthesis of the essential amino acid L-phenylalanine, the tautomerization reactions of the nucleobase guanine, and the alkaloid Theobromine (Fig. ). These molecules have between 9 and 13 heavy atoms and are significantly different from QM9 molecules. We considered the scenario in which only the neutral intermediates are involved, and the catalysis is ignored although for Strecker's synthesis, the reaction proceeds by catalysis, and the intermediates involved in the reactions could be charged. The corrected reaction energies calculated using both SCF and post-SCF methods are provided in Table . The reaction energies after the correction are similar in most of the cases irrespective of the SCF method applied to compute the DFT reaction energies although the accuracies vary between functionals. It is evident that the correction to ∆E P BE moves the reaction energies closest to the G4MP2 values compared to B3LYP-D and M06-2X. Nonetheless, the bond-based correction method improves the reaction energies for all the three functionals irrespective of the SCF method used to compute the molecular energies. Therefore, in general, our correction approach provides G4MP2-like accuracy at a much lower cost for both SCF and post-SCF DFT methods. The fact that the post-SCF energy dependent-method is equally effective to provide accurate reaction energy will increase the scope of the applicability and extensibility of this work. Lastly, although the linear regression was performed using only reactions of the A ↔ B type, these examples indicate that the error correction is also applicable for reactions of types A + B ↔ C and A + B ↔ C + D.