Upon ingestion, glycyrrhizic acid is almost 100% hydrolysed down to its aglycone, glycyrrhetic acid (see above). The latter therefore is a bioavailable form for the body cells. In this regard we have separately docked the aglycone into the E channel. It did form a very similar docking pose as the original glycoside; the Vina score (-10.2 kcal/mole) was also very close to -10.6 kcal/mole for the parent drug (Fig. ).