We show that TiTannic gels are stable and well-tolerated, and elicit a mild but persistent foreign body reaction. Through mass spectroscopic analysis of tissue samples, we show that titanium accumulation in distal tissues remains low over the 14-week study period. Finally, we show that TiTannic gels exhibit more sustained release (from <1 day to >10 days) compared to a commonly used in vivo gelation system (i.e., Pluronic F127 hydrogels) when loaded with the clinically used corticosteroid dexamethasone. Taken together, these results provide a solid foundation for further exploration of TiTannic gels in biomedical areas such as drug delivery and regenerative medicine.