To assess the practical use of the mixed fine-tuned model in synthesis planning for drug-like targets, we constructed a multi-step retrosynthesis prediction tool using neural-guided A* Search, based on the algorithm used in Retro*. The two drug-like targets included CZS-035 and ADD (Figure ), for which syntheses were reported in 2023. The exact reactions employed in these synthesis are therefore absent in our training set, which contains reactions from patents and literature up to 2022. For comparison, we also built an analogous multi-step retrosynthesis tool employing the baseline single-step model, maintaining identical search settings.