For predicting the solvation free energy of neutral solutes using COSMO-RS, an RMSE of 0.67 kcal mol -1 was previously estimated for both aqueous and non-aqueous solvents. To Figure shows that the error between neutral solvation energies is significantly higher than the RMSE of 0.67 kcal mol -1 reported previously. The overall MAE / RMSE was 1.09 / 1.57 kcal mol -1 , driven by the high representation of data in water. Although RMSEs in DMSO and NMP are lower than the previous 0.67 kcal mol -1 benchmark, they represent only a very small portion of the data. The RMSE values in water, DMF, methanol, and ethanol are much larger; in DMF, the RMSE exceeds 2.1 kcal mol -1 .