In 2006 Kozmin et al. reported the first example of hydroamidation of internal alkynes . They found that AgNTf2 can promotes the addition of second-amides or carbamates to the triple-bond of siloxy-alkyne successfully in the room temperature within 30 min (Scheme 1a). In this reaction, the E-configured Markovnikov product is exclusively obtained. The authors also found that the commonly used ynamides and simple internal alkynes are inactive in the same condition. Based on deuterium label experiment, the author proposed a silver induced nucleophilic addition mechanism (NUA mechanism, Scheme 1b). In this mechanism, the silver(I) coordinated with siloxy-alkyne 1 to form π-complex INTA, the amide 2 then nucleophilic attack the siloxy-alkyne 1 to form Z-INTB. Proton transfer of Z-INTB lead to final product Z-3. The nucleophilic attack step is thought to be rate determine step (RDS).