As a next step, we sought to validate our tetrazole models using the trigger hypothesis, which states that the bulk decomposition of an energetic material is dominated by the initial decomposition of the explosophore with the lowest activation energy prior to the initiation of an exothermic chain reaction. We explored this idea in the context of the ditetrazole HEMs in our dataset: in cases where an HEM contained two non-identical tetrazole units, we hypothesized that the molecule's bulk Tdec would be closely related to the lower predicted Tdec of either of the two tetrazole explosophores. As such, we used our statistical model for Tdec (Figure ) to generate predictions for an external test set of 12 non-symmetric ditetrazoles and selected the lower of the two predicted values as the predicted Tdec for the HEM. This model predicted nine non-symmetric ditetrazoles with a mean absolute error of 25 °C (Figure and 5C, green entries). This result serves as a good external validation for our original models and verifies the applicability of the trigger hypothesis for prediction of tetrazole decomposition temperature.