The Twin Star Network is more robust than the most edge efficient approaches but loses robustness quickly with an increased number of molecules: since the condition for disconnection is two edges being removed from a single molecule, the probability of this condition being met increases with the total number of edges removed. The N-Node Edges Network, the Redundant MST Network, and the Cyclic Network are more robust network approaches which rarely show disconnected graphs at an edge failure rate of 10% . However, the networks also start to break down with a 25% failure rate and increasing numbers of molecules. The two variants of the Maximal Network approaches were the most robust approaches in both failure rate cases. The Heuristic Maximal Network approach however gets disconnected with small numbers of molecules, which is expected as the method is only proposed for a very large number of molecules.