To exemplify a real reaction under these conditions, we will use the thermal decomposition of a high explosive (HE), namely, 1,3,5-triamino-2,4,6-trinitrobenzene (TATB). HE materials make an ideal test case as they undergo a wide range of mechanochemical reactions due to shock heating, react on MD timescales for a wide range of temperatures, are moderately complex molecular structures, and have easily controllable normal modes that are mechanochemically influential. We will compare the theory presented here to molecular dynamics simulations using the many-body steered MD method (MBsMD) to control the intra-molecular strain level. All strain and total energies in both MD simulations and theoretical solutions will be presented in units of kelvin, assuming a classical specific heat, to better compare to the no mechanochemistry case.