Altogether, these data suggest that differences in the host-guest equilibrium in such systems in is mainly controlled by the interactions/affinity between the guest (2) and the effective host cavity, thought of as that accessible for the guest considering the cage and the presence of eventual encapsulated co-guests. From the calculated G, we could also estimate the host-guest affinity constants (K enc ) for all the host-guest systems (Table ). It is worth noting that the K enc for the 2 cis conformers are in general orders of magnitude higher than those of the 2 trans complexes. In particular, this is evident for the 2 • 3 ⇢ 1 complexes.