and 8c, Table , Supporting Information) can facilitate the adaptation of the peptides to the membrane environment and their incorporation into the membrane. In contrast, a minor modification, such as the single-residue D-stereoisomer 7a compared to the parent p1, does not result in sufficient changes in the distribution of surface hydrophobic properties and/or backbone conformations, as anticipated. In summary, predicting toxicity changes solely based on surface hydrophobicity mapping and/or backbone conformation populations appears highly challenging (Figure , Table , Supporting Information).