The above findings provided evidence that the presence of multiproduct reactions is deleterious in the context of the performance of finding synthesis routes to target molecules. The absence of ambiguous reactions yielded further improvement to the performance, albeit to much smaller degree. Yet, we asked the question, whether the original FG query that we used on our small-scale prototype database of ∼100K reactions, might be comparable to the performance of the SP query for synthesis graph query execution time.