Later, the tertiary structure can be predicted, often by the I-TASSER . However, the obtained models still need further refinement. For that, ModRefiner 77 and GalaxyRefine 78 are common choices. At this stage, it is evident that the way to obtain a structure of this type of modulator is quite demanding. Molecular docking to the immune receptors is similar to blind docking, meaning that there is a predefined binding site. The ClusPro server is able to perform such computations. Further investigation of the dynamical properties is usually performed using Normal Mode Analysis (NMA) rather than all-atom MD simulations. However, the latter one (if used) can provide better and more detailed insight. A simulation of a possible immune response, which usually concludes the in silico part, is often performed using the C-ImmSim tool .