Beside this, Ar is involved in one of the only two bits dealing with higher distances (d9). This might suggest that aromatic rings can be located away from the core group of hydrogen-bond mediated interactions. Moreover, the first two ErG bits are almost 10 times more important than the others, meaning that these two first features dictate the vast majority of selectivity recognition: indeed, between CRBN and VHL we cover almost 91% of any training or test dataset (see Figure ).