Since neither the Vina nor Vinardo scoring functions produce reliable low-energy structures or conformational rankings in flexible ligand docking, the outcome depends largely on luck, determining how many false positives and false negatives are present in the docking project. This is why I developed the QFVina docking scheme, where accurate and reliable DFT-D4 conformational strain energies are obtained from the input conformations. Combining this with the Vina intermolecular (and implicitly desolvation) scoring could significantly reduce both the number of false positives and false negatives, providing a more reliable docking hit list.