Going from native βCD to H26DM-βCD leads in all cases to either an improvement in affinity or an essentially unchanged affinity, with a change in the mean binding free energy from -21.5 to -23.3 kJ/mol, and the greatest improvement, ~4 kJ/mol, observed for PMT. Although promazine and chlorpromazine differ only in the replacement of a hydrogen by a chlorine, chlorpromazine binds more tightly than promazine in all cases, with a maximal improvement, relative to promazine, of 4.6x in the case of H6M-βCD. Finally, we note that our result for the binding free energy of CPZ with βCD, -22.7 kJ/mol, agrees closely with a prior ITC measurement (-22.4 kJ/mol) .