The presence of the tau protein at the "TAA" position in the promoter and enhancer, which incorporates the transposed telomeric fragment sequence, will alter the region's structure. This will interfere with RNA polymerase II's smooth binding to the promoter region and transcription initiation. This transposition mutation of the promoter and enhancer may not alter the exon sequence of the transcribed gene; however, it will impact the gene's transcription and result in low transcription efficiency. The tau protein telomeric transposition method can gradually inactivate multiple identical gene copies, rendering them incapable of transcription. Simultaneously, telomeric transposition shortens the telomeres of DNA, which prompts cells to progressively enter telomere shortening-induced cell senescence.