Most cheminformatics open-source programming toolkits have a rather high entrance barrier due to the abovementioned aspects. Also, the quality of available documentation and tutorials varies. This is especially critical for young researchers new to the field who have to spend a lot of setup time before being able to work on their research projects. Therefore, online tools for cheminformatics are becoming increasingly popular due to their usual ease of use, adequate documentation, and the fact that no or only little programming knowledge is required to use them . The use of web-based solutions or solutions that are driven by Application Programming Interfaces (APIs) offers a lower entrance barrier. In addition, these services are platformindependent and can be easily integrated with software utilities, databases, repositories, and cheminformatics data management workflows .