Particularly, the type of salt and its concentration can alter the solubility of a solute (e.g. in what is known as the Hofmeister effect) . Such salt dependence also interacts with the choice of water model. Particularly, one computational study reported surprising differences in the salt dependency of binding enthalpy (comparing TIP3P, SPC/E, TIP4P-Ew, and OPC water models) during MD simulations for cucurbit uril host with a neutral guest . Despite the system being non-ionized, the salt concentration (and the choice of sodium and chloride parameters) affected the behavior and thermodynamics of water, raising issues regarding selection and adjustment of water models for charged groups . Incorrect ionic behavior (i.e. dielectric constant, dipole moment, solvation, and excessive ion-pairing and/or ion pairing strength) has been shown to be due to unbalanced force field parameters .