The functional diversity of KARs is further expanded through RNA editing and alternative splicing . In particular, KARs expressing GluK1 are predominantly located in the hippocampus, Purkinje cells, cortical interneurons, and sensory neurons undergo these processes, producing four isoforms of the C-terminal domain and two N-terminal domain isoforms, GluK1-1 and GluK1-2. The GluK1 subunit is only found in the GluK1-1 form, with an extra 15 amino acids in the amino-terminal domain (ATD) . This variation may give KARs that carry its unique characteristics. The impact of this N-terminal splice inserts on the modulation of KARs by auxiliary subunits such as Neto proteins remains unexplored.