Classic molecular dynamics (MD) simulations have proven to be a useful tool for gaining a deep microscopic understanding of the structural and dynamical properties of liquids at interfaces with carbon-based layered materials, in particular methanol confined between graphite surfaces. Mosaddeghi et al. revealed that at high-pressure and confinement conditions the methanol molecules organize in a hexagonal arrangement with CO bonds perpendicular to the graphite surfaces. In the absence of one of these conditions, the hexagonal arrangement is destabilized and the methanol molecules organize with their CO bonds oriented parallel to the graphite surfaces.