It is interesting to compare these results with the intuition of the chemists who have deep experience of this series and who are familiar with the SAR. A recurring observation was the sensitivity of the length of the ether linker between triazolopyrazine core and northwest phenyl group, with a spacer of two methylene units (between phenyl ring and oxygen) leading to far higher potencies than other lengths. The Davy Guan prediction involving the shorter linker, and the Molomics 1 prediction without the pendant phenyl ring, lie in the class of inactive compounds subject to human retrospective wisdom (i.e. the "I could have told you that" class). In contrast, the Exscientia compounds were thought by the human team to be likely to be potent, but only one performed well (i.e. the "that's odd" class). Lastly the Optibrium/Intellegens suggestion that included the tert-butyl pendant was thought by the human team to be a certain inactive, given what was known of variation in that part of the molecule, yet this compound displayed good potency and is a particularly useful outcome (i.e. the "I welcome our machine overlords" class).