The utility of DCC as hit-identification strategy in drug discovery has been demonstrated for a range of biological macromolecules as targets, including enzymes, receptors, nucleotides, and transmembrane proteins. While two-body DCC scenarios harnessing interaction of reversibly formed library members with one templating biomolecule are well-established, applications with multiple templates are rare. Examples of multiple templates include an allosteric binding-guided DCC where macromolecular cyclic library members were assembled around one template, while encapsulated in γ-cyclodextrin as second template and a multiprotein DCC approach where multiple proteins were introduced as templates of one DCL to simultaneously identify selective binders for each template. To the best of our knowledge, application of DCC to the development of bivalent molecules directed and driven by ternary complex formation of library members with two templating proteins remains unprecedented.