Polymer brushes are increasingly being utilised for a broad range of biomedical applications , ranging from tissue engineering and implant coatings, to cell patterning for cell-based assay development, or to regulate physico-chemical properties and the biofunctionalisation of biosensors. To a large extent, an essential brush property shared by most of these applications is the ability to regulate protein interactions and diffusion to substrates from which brushes are tethered. Hence, the exceptional protein resistance of polymer brushes enables to control their specificity of binding for biorecognition or to promote cell adhesion , whereas other brushes modulate the mechanism of adsorption and ultimate conformation of bioactive proteins . In many cases, the ability of brushes to modulate protein-surface interactions and adsorption is associated with neutral brushes that do not promote strong interactions with other macromolecules.