We believe that the development of multiscale high-pressure simulation techniques will become increasingly important in the future. Since the strain applied to a macroscopic object does simply correspond to the strain exerted on the constituent molecules, multiscale models are promising tools to improve the comparability between experiments and calculations. Moreover, the differentiation between isotropic and anisotropic compression is crucial, e.g., to gain an understanding why compression can lead to bond rupture at the molecular level. Following up on the possibilities for improvement of high-pressure simulation methods will make sure that the fascinating field of computational high-pressure chemistry continues to thrive.