Triterpenoid quinone methides derivatives have been reported as promising hits against L. donovani promastigotes, in particular, 20-epi-isoiguesterinol (RRKSDDREVOXSJD-TXARQUJHSA-N (Q27134610), IC 50 = 0.027 μg/mL or 0.064 μM) and isoiguesterin (RUVGAOXZLPFVKY-IPTPSVHJSA-N (Q27134609), IC 50 = 0.032 μg/mL or 0.079 μM) . One of them, isoiguesterin (Q27134609), is annotated with confidence by SIRIUS/CSI:FingerID and ISDB in Pristimera indica (Q11075650, Celastraceae) roots extract (feature #241 in PI mode) (query, Figure ). When looking at the MS 2 spectra of this feature (see GNPS dashboard visualization), one can observe a fragment at m/z 201.09 characteristic of the quinone methide moiety of these triterpenoids (Q7844276) . Using the recently developed MassQL language, it is possible to retrieve all features corresponding to a fragmentation spectrum in which this fragment is observed . This search revealed that among the 761 features of this extract (PI mode), 36 present this characteristic fragment with an intensity representing at least 50% of the most intense peak of the spectrum (MassQL query job available here). A visualization of the results of this query on the generated MN for the P. indica extract showed that these analogs are part of a cluster of potential structural analogs (Figure B) . At the structural annotation level, it is possible to use the Sachem cartridge to retrieve analogs of a compound of interest among other WD compounds . Such an analysis revealed that, among 99 different confident structural annotations, 10 structures have a Tanimoto similarity superior or equal to 0.8 to isoiguesterin (query, Figure ). This example shows how the ENPKG structure can be exploited to take advantage of raw or semi-interpreted data (spectral data in this example) or processed data (annotations) to investigate a research question rapidly.