Nerve growth factor (NGF) is a protein that prevents viral reactivation in neurons . NGF deficiency works as a stressor on neurons. It may share a similar second messenger with heat or cold stress-induced reactivation of latent HSV-1 . The analysis of the immunological biomarker profile during acute Zika virus infection found that CXCL10, a chemokine linked with brain injury, was overexpressed . Numerous viruses physically connect to and internalize cells via growth factor receptors and convey receptor tyrosine kinase signals for replication . It has been demonstrated that inhibiting the NGF receptor TrkA pharmacologically inhibits influenza virus multiplication . Through TrKA signaling, NGF promotes HIV-1 replication in primary macrophages . The improvement of HIV-1 reproduction by NGF occurs during the late stages of the HIV-1 replication cycle and is accompanied by an increase in viral transcription and output . Human rhinovirus (HRV) induces an increase in the NGF/TrkA pathway in airway epithelial cells. It enhances viral replication by enhancing HRV entrance via ICAM-1 receptors and inhibiting nasopharyngeal cell death . NGF is a critical component in the survival of bronchial epithelial cells during infection with a respiratory syncytial virus . After nerve growth factor deprivation, the primary sympathetic neuron culture includes latent HSV. It demonstrates the critical role of the nerve growth factor in extending the incubation period of HSV .