In this study, we find that msesMD constitutes a potentially useful tool in overcoming energy barriers to sample rare minima that are usually accessed at very long timescales. The msesMD method reasonably reproduces free energy surfaces obtained by multi-microsecond unbiased MD simulations and is approximately five times faster in achieving this, acquiring 245 ns in 5 days, relative to the 25 days required to generate 10 s MD simulations using hydrogen mass repartitioning; this is obtained using four Infiniband connected 24 core Haswell E5-2680 nodes (msesMD) and three Nvidia K20 GPU nodes (unbiased MD). It is noted that without the use of HMR, the unbiased simulations would have doubled the calculation time. Indeed one could envisage the use of msesMD in tandem with HMR in order to further lower simulation times.