In neurons, tau protein can bind to DNA and localise to the nucleus . The protein is organised into constitutive heterochromatin and co-localizes with the nucleolar protein nucleolin and human AT-rich α satellite DNA sequences . Through its interactions with microtubules and chromatin, tau contributes to the integrity of chromosomes . By interacting with certain DNA sequences in the nucleolus and pericentromeric heterochromatin, tau protein is able to localise to specific regions of the nucleus . The role of tau in transposon activation and additional accelerated ageing have been associated with increased quantities of nuclear tau . Some RNA genes' heterochromatinizationand/or nucleolar organisation are facilitated by nuclear tau protein .