To develop robust methods that work for different oracles, we tested our optimized configuration against both oracle functions, ROCS and ADV (Figure ). Overall, RL-AL optimized drastically improves the oracle call efficiency relative to the RL-baseline, from 35±6 and 818±43 (23 fold increase) to 37±8 and 2 459±273 (75 fold increase) hit scaffolds found over 30 000 oracle calls, for ROCs and docking respectively (Figure ). The solution diversity is slightly reduced, 0.251±0.018 and 0.286±0.005 for RL-AL compared to 0.178±0.003 and 0.162±0.002 for the baseline, which is more than compensated by the much higher number of hit scaffolds found.