Specifically, amprenavir has a free energy of -7.29 kcal/mol and modestly inhibits replication of SARS-CoV-2 in vitro . Outside of clusters A, G, and U, other antiviral drugs include influenza neuraminidase inhibitors peramivir and oseltamivir, HIV non-nucleoside reverse transcriptase inhibitor doravirine, and HCV NS5B polymerase inhibitor sofosbuvir, which displayed activity against SARS-CoV-2 .