Illustration of an idealized COF-based Xe/Kr separation. A column is packed with COF adsorbent material. The Xe/Kr mixture is fed to the column. The COF selectively adsorbs the Xe, letting the Kr pass through the column. After the adsorbent is saturated with Xe, heating or pulling vacuum desorbs the Xe in the COF and regenerates it for another cycle of adsorption.