The force RMSE is significantly lower than RMSEs obtained for isotropic CG models using the MS-CG method with a similar coarse-graining level and is comparable to the RMSE for a multi-site CG benzene model with many-body interactions. The optimized CG pair potential is shown as a function of intermolecular distance for several relative orientations of benzene dimers in Figure and for more relative orientations in the SM (section SVI B).