Figure : In 2 out of 3 pictured molecules, lig 215 and lig 25, we see smaller ranges of q bond di erences when charging with OpenEye AM1-BCC ELF10 as opposed to Amber-Tools AM1-BCC. In these molecules, we see a smaller range of G using the less variable charging method, OpenEye AM1-BCC ELF10. In lig E27, OpenEye AM1-BCC ELF10 and AmberTools AM1-BCC have a similar maximal range of q bond di erence, but OpenEye AM1-BCC ELF10 charging results in fewer bonds with variability above 0.02 e.