The objectives for the AutoGDE design include automation of gas and liquid handling, coupling to analytical detection of reaction products, and simplifying the exchange of working electrodes to enable future automation of sample loading and unloading. This last aspect required the greatest departure from traditional GDE experimentation, which relies on manual assembly of fasteners and gaskets to maintain hermetic seals during operation. While modern and future robotics may rival the dexterity of human GDE assemblers, we aimed to simplify the mechanical insertion of a GDE sample into the electrochemical cell as well as the establishment of an operational gas-electrolyte-catalyst boundary. Toward this end, we commenced with a cell design composed of 3 custom fixtures corresponding to the core components of a GDE electrochemical cell: the counter electrode (CE), working electrode (WE), and gas handling (GH) fixtures.