At this stage, a pivotal asymmetric proton transfer was required to restore the stereochemistry at C10. Towards this end, Deng's pioneering asymmetric proton transfer methodology performed flawlessly. Thus, treatment of 22 with 10 mol% of Cinchona alkaloid-derived quinoline-N-oxide 23 cleanly effects the desired 1,3-isomerization producing conjugated butenolide 24 in nearly quantitative yield (gramscale). Concerned that racemization might occur during a required reduction/deprotection sequence, determination of enantiopurity was delayed. With the near-complete carbon skeleton of 1 in hand, the oxazoline ring that served essential roles (aldehyde surrogate, directing group) was disassembled in chemoselective way. This one-pot sequence was accomplished by: (1) quaternization of the oxazoline moiety (MeOTf), (2) treatment with lithium triethylborohydride (Super Hydride®), and (3) subsequent PPTS-mediated hydrolysis of both the intermediate oxazolidine and allylic-MOM-ether to afford aldehyde 25 in 65% yield (gram-scale); this material's enantiopurity was determined as being 91% e.e., suggesting that Deng's methodology indeed proceeded asymmetrically and the subsequent transformations resulted in negligible enantio-erosion. This constituted a formal total synthesis of (-)-1, as Trauner reported there to be no further enantio-erosion during the required final steps. 2e The reported end-game protocol was applied (Appel reaction followed by diastereoselective NHK macrocyclization) to deliver > 600 mg of 1 in a single pass. Although these last two reactions are known, it is worth noting that we have now performed each of them on gram-scale, observing only slight variations in isolated yield and reported diastereoselectivity. The route described herein to access 1 could, in principle, be executed by two chemists in about 10 days starting from commercial materials.