The optimization campaign is initialized with 55 input conditions, suggested from Sobol sampling to ensure good coverage of the design space. After synthesis, the 𝑇 𝑔 and styrene incorporation of the terpolymer were determined to form the dataset of experimental input and output conditions for training surrogate models. Thereafter, two iterations of BO, consisting of 20 samples and 14 samples respectively, were performed. In total, 89 terpolymer samples were synthesized at the end of the optimization campaign. All relevant data, including the detailed experimental procedure, 𝑇 𝑔 and styrene incorporation of all terpolymer samples are included in the Supporting Information (SI).