Accordingly, the model clearly shows that the growth of the COF-300 nanoparticles conforms better to an isotropic model that yields a maximum particle diameter of approximately 40 nm after 48 hours of reaction (Figure ). Note that the growth mechanism observed for COF-300 nanoparticles using the micellar approach is significantly different from that of sub-20 nm 2D COF nanoparticles, produced following the same methodology. While in the case of COF-300 the SAXS scattering profiles better fit to a three-layer spherical model, sub-20 nm 2D COF nanoparticles revealed an anisotropic growth mechanism characterized by an initial lateral growth, resulting in a disk-like structure, followed by an increase in particle size perpendicular to the disk plane and driven by the π-π stacking of 2D COF layers. Undoubtedly, the hydrophobic micellar core offers a unique platform to explore and understand the intricacies of COF-300 synthesis and growth, paving the way for unprecedented possibilities in the realm of 3D COF research and beyond. Note that understanding the growth mechanism of crystals is crucial for controlling their size, structure, and consequently, their properties and functions, including processability. For instance, we have successfully demonstrated that the utilization of the micellar approach enables the formation of stable colloidal solutions of COF-300 nanoparticles under mild conditions, a feature that can enable their processability across scales and on multiple substrates and conditions, owing to its aqueous nature. To provide concrete evidence supporting this statement, we have employed the colloidal solution for the direct functionalization of complex 3D motile microstructures with COF-300 nanoparticles to create the first magnetic 3D COF-based microscale robots (COFBOTs).