The RDF between neo-neo is computed in pure water, water-urea, water-TMAO, water-Urea-TMAO using two different force-fields namely Netz and Garcia which is shown in Figure . It is clear from the plots the population of neo-neo contact pair (peak) follows the order: water-urea-TMAO> water-Urea> water> water-TMAO for Garcia's TMAO model. The order is as follows: water-Urea-TMAO> water-TMAO> water-urea> water when Netz force field of TMAO is used. The neopentane association at contact pair state is always higher in water-urea-TMAO mixture than other three solutions irrespective of the choice of TMAO's force-fields.