Using the enzyme commission (EC) number and the UniProt ID, we classified all complexes of CSKDE95 and CS244 by protein family. The distribution of complexes among families is similar in both benchmark sets (Figure ), with a majority of hydrolases. These proteins are crucial in various biological processes, such as breaking down nutrients into smaller units for digestion. The transferases class is the second most represented one and contains a majority of kinases (75% in CSKDE95 and 87% in CS244), which are frequently targeted for anti-cancer therapies as they regulate cell activity. Besides these two predominant protein families, the two benchmark sets contain a large variety of diverse targets.