A broad range of strategies have been proposed for the incorporation of growth factors and bone morphogenetic proteins into biomaterials and their release or presentation, for tissue engineering and regenerative medicine applications . Hence, self-assembled monolayers, hydrogels and polyelectrolyte multilayers can capture or allow the coupling of BMP-2 and other growth factors and cytokines, for example using hyaluronic acid backbones or histidine tags, to regulate cell adhesion and motility, neural stem cell maintenance, as well as osteoblast differentiation and bone regeneration . Whilst these approaches are not directly aiming at mimicking the binding of growth factors by glycosaminoglycans (GAGs), they were found to be effective and allow the control of a broad range of other parameters, such as matrix stiffness, patterning and the presentation of other ligands for cell membrane receptors, such as integrins . Sulfated GAGs such as heparin, heparin sulfate and chondroitin sulfate, which have the capacity to bind a range of growth factors, have been introduced in a broad range of biomaterials designs, including for the coating of fibres, the backbone of hydrogels, the formation of polyelectrolyte multilayers, or in engineered monolayers, for the capture of growth factors including basic fibroblast growth factor, TGFb and vascular endothelial growth factor .