Three hit compounds (9, 13, and 39) were found to bind adjacent to the active site entrance. Hit compound 9 was tested as the racemate, but only the S-enantiomer could be fitted to the electron density. This binding site is a small cavity on the surface of the FabF protein next to where the caged ring system of platencin is located (Figure and Figure ). The cavity is formed by residues from both chains.