Number : The number of hydrogen bonds and binding energy between adhesin-a HpaA-annexin interactions: Finally, to understand the HpaA protein interaction with the Annexin protein, I have also performed modeling of the HpaA-Annexin protein complex. Since the HpaA protein is present on the surface of the bacteria and the annexin protein is located on the surface of the human gastric cells, their interactions will be critical in understanding the bacterialhuman cell binding mechanism. AlphaFold3 was used to model the interaction structure. Since the HpaA protein 3D structure has been recently resolved, this interaction structure will also be the first HpaA Annexin protein complex. This research will be instrumental in understanding the interaction of these two proteins, which aid in the binding of H. pylori to human gastric cells.