examined. Therefore, one needs to keep in mind that we still need in-depth studies revealing the differences in the mechanism of action in relation to different receptors. We believe that in the coming years, more groups will include analyses related to potential off-targeting effects, as well as that there will be an increase in interest in the screening of natural compounds databases for proposing novel small-molecule modulators. Regarding methods, we are expecting an increased contribution of AI-supported screening, especially in ligand-based screening.