Five GA runs are performed with different starting populations of 100 molecules taken randomly from a subset of tertiary amines of the ZINC database . Figure shows the evolution of the ts-score of the best-performing molecule in the population over 100 generations for five separate GA runs. In each run, the score drops drastically by up to 10 points in the first four generations. This jump can be largely attributed to the increase of the SA score component of the overall score The azetidine moiety is present in one of the runs starting populations but does not survive after the first evolutionary step. Instead, the azetidine ring is rediscovered by the GA (via mating operations) as a catalytic motif and virtually outcompetes all other motives as 498 out of the final 500 molecules from five runs contain the azetidine moiety. The first time a molecule containing an azetidine ring performs best in the population is marked with a black cross in Figure . Although the azetidine ring is discovered as preferable binding motive within 25 generations, substantial improvement of more than 5 points are archived by the GA over the following 75 generations.