For the following analysis on EN-ZYMES22, all values are at the CBS (3,4) level. The reference values we presented for these models in 2019 were based on DLPNO-CCSD(T 0 ) with the older, noniterative triples correction, so as well as an initial comparison of CPS (5,6) and TightPNO to CPS (6,7), figure 5 also compares DLPNO-CCSD(T 0 ) to DLPNO-CCSD(T) with iterative triples as used herein. Looking first at the DLPNO-CCSD(T)-based approaches, we see that CPS (5,6) (MAD of 0.29 kcal/mol and largest deviation by magnitude of -0.71 kcal/mol) is again less accurate than standard TightPNO (MAD of 0.17 kcal/mol and largest deviation of -0.33 kcal/mol), but the MADs are relatively small, and both MDs are very similar. The (T 0 ) triples correction increases the deviations of standard TightPNO and the two CPSextrapolated alternatives, with DLPNO-CCSD(T 0 )/CPS (6,7) having an MAD of 0.2 kcal/mol and largest deviation of 0.57 kcal/mol compared to DLPNO-CCSD(T)/CPS (6,7). While the difference between the triples corrections is not significantly large here, we still prioritise the use of the newer (T 1 ) correction as it is theoretically more rigorous.