A similar ration between the three reaction types, that is the predominance of association 336 reactions was also found for CRN-T despite the smaller number of compounds and reactions. While Chemoton allows for the autonomous construction of CRNs, the large uncertainty of quantum chemistry methods for predicting absolute values of rate constants still remains. To exemplify issues with absolute rate constants for the CRNs studied here, we have depicted two sets of the experimental and quantum chemical rate constants, k exp O 3 and