In this CRN, the intermediates are nodes that on average have a higher contribution than other species to the connectivities in the graph, given that their degree (𝑘 4-9 =7.1) is higher in comparison to the degree of the reactants (𝑘 1-3 =5.3) (Fig. ). The node 10 has an artificially high value (k10=10) because it summarizes several species as products. The degree for nodes 11 and 12 that represent the flow components, S (k11=3) and W (k12=10), reflects the inflow of the three reactants and outflow of ten species. That the node for Tr (i=4) has the highest degree (k4=12) reflects the fact that the design of the CRN is built around the key enzyme Tr (see conceptual model in Fig. ). A different pattern emerges when we considered the cci (Fig. ). On the node for Tg (i=1), for instance, cc1=0.2 as 1/5 of the wedges can create the feedback triangle representing the conversion of Tg into Tr (via the auto-activation, Tg  Tr, and autocatalytic steps, Tg + Tr = Tr•Tg  2 Tr). For Tr•Tg, node 7, cc7=1/4 is slightly higher because it has the same number of triangles but one less wedge. The cci for 4, species Tr, is significantly lower (cc4=1/10) as this node has neighbours that are not shared with 1 and 7. Overall, we observed two distinct responses: A cci for any node is (i) non-zero for species that are involved in the positive feedback loop (Tg, Tr, and Tr•Tg), and (ii) zero for species that are not involved in the positive feedback loop. Notably, the auto-activation step was included as a side reaction in the massaction model of the enzymatic oscillator as it was required to provide the initial activation of Tr. In this case, the auto-activation, plays a critical role as well, because it is required to complete the feedback triangle between 1, 4 and 7, making the numerator of cci non-zero.