Heat maps for modifications versus disease targets show little correlation between the disease and the modifications on the therapeutic RNA (Supplemental Figure and). The strongest associations between modifications and disease targets are for age-related macular degeneration and pancreatic cancer, and these associations appear to be related to the types of RNA that target these diseases. Age-related macular degeneration (Table ) and pancreatic cancer (Table ) are targeted by aptamers, which are extensively modified. However, overall, there is little correlation between the type of RNA and the targeted diseases (Supplemental Figure ), suggesting any RNA can be explored to target any disease.