Overall, CIME dealt well with datasets of up to 20,000 compounds and 1,000 fingerprints. Beyond these thresholds, we experienced longer loading times (i.e., ¿= 5 minutes). The results are better if fingerprints are not handled by the system; that is, the projection is precalculated and stored in the SDF. Not having fingerprints uploaded or computed by CIME resulted in a considerable drop in memory usage in both back-and front-end. We tested datasets of up to 100,000 compounds with only 1 fingerprint to simulate this scenario in our benchmark, where CIME generally handled the datasets well, with only LineUp's initial loading being slow at 5-20 seconds when over 60,000 compounds were used.