Utilizing the built-in MEME tool, we compared the sequences of Dynamin and GTP+GDP-binding proteins from the Uniprot database with the monkeypox virus protein F13. Table displays the search results for the Tr-type and GB1/RHD3-type domains found in the F13 protein of the monkeypox virus. The Tr-type A-C and GB1/RHD3-type A-D motifs overlap with the GTPase domain of dynamin. The presence of the Mg2+-GTP binding site, Asn132, in GB1/RHD3-type A suggests that this activity is primarily responsible for the GTP/GDP-binding region of the F13 protein's G domain. Since Tr-type B has a lot of serine and overlaps with PK-Tyr-Ser-Thr A, it is likely that Tr-type activity is role of the change in shape caused by the hydrolysis of GTP to GDP.