Remarkably stable aqueous suspensions of Gem-based polymer prodrug nanoparticles were successfully obtained in all cases over a period of more than 3 months. Interestingly, nanoparticles G1 and G2 showed similar sizes before and after dialysis (~60-80 nm), conversely to nanoparticles G3 (130 nm), presumably because of the high Gem content, as also observed with PtxMA (Figure , Table ). Importantly, insertion of BMDO units in the copolymer backbones did not affect the colloidal stability of nanoparticles in water (Figure and c). As shown by TEM, monodispersed spherical nanoparticles were obtained with average diameters matching the DLS data (Figure and e, Table ).