When only the intermolecular components of the ligand non-bonded interactions (Coulombic or Lennard-Jones (LJ)) are removed, this is often termed "decoupling", while "annihilation" may refer to removal of both the inter-and intramolecular components. However, the terminology of Gilson et al. is used here: 38 "decoupling" denotes removal of of the ligand intermolecular interactions while enforcing receptor-ligand restraints, irrespective of how the intramolecular interactions are treated.