with both fingerprints (Figure ). Moreover, TMAP performed better than t-SNE in the NPs cluster creation with both fingerprints. A interactive version of the scatter plot created with TMAP from MAP4 fingerprints (Figure ) is freely available at . To open the interactive map, download the file and open it in web explorer. Since TMAP performed better than t-SNE, and MACCS keys (166-bits) and MAP4 fingerprints showed a similar efficacy in the TMAP, the comparison of LaNaPDB with the reference databases was made with TMAP and MACCS keys (166-bits) fingerprint (Figure ). It can be observed that LANaPDB overlaps with COCONUT in well-defined areas, nevertheless, the approved drugs are more dispersed and some of them overlap with compound in LANaPDB (Figure ).