The physico-chemical properties and primary structure parameters of the 7 polyproteins RdRp region of the SARS-CoV-2 virus isolate is given in Table . RdRP forms an important part of the viral genome where in the RNA viruses its function is to catalyze the synthesis of the RNA strand complementary to a given RNA template. The isolates SI200040-SP orf1ab polyprotein and the isolate SI200121-SP orf1ab polyprotein had 2 reading frames as compared to the rest of the isolates which had 3 reading frames. The presence of multiple reading frames suggests the possibility of overlapping genes as seen in many virus and prokaryotes and mitochondrial genomes. This could affect how the proteins are made. The number of amino acid residues in all the polyproteins were the same expect one isolate SI200040-SP which had one amino acid more than the other polyproteins. The extinction coefficients of the two isolates SI200040-SP orf1ab polyprotein and the isolate SI200121-SP orf1ab polyprotein was much higher compared to the rest of the polyproteins.