To comply with government's regulations (e.g., USP <232> in the United States), the pharmaceutical industry must ensure that heavy metals are below their toxic levels in active pharmaceutical ingredients (APIs). Among heavy metals, palladium is the most frequently used transition metal in chemical synthesis and must be below 10 ppm in APIs, according to USP <232>. Therefore, process chemists must develop a specific and highly efficient palladium-scavenging protocol for each API to meet the safety regulation. This is accomplished through screenings of dozens of potential workup protocols and scavengers, among other purification techniques. This process generates several dozens of samples in which to quantify palladium. Meanwhile, new scavengers continue to emerge, adding options to explore.