Whereas the conformation of polymer brushes, including polycationic systems, has been the topic of many studies, little is known of the morphology of polymer brush-DNA or RNA complexes. It is well established that weak as well as strong polyelectrolyte brushes are inherently responsive systems. Their solution morphology is strongly impacted by environmental parameters such as pH, ionic strength, temperature, and the presence of small molecules . In particular, the pH, solvent and ionic strength response of weak polybase brushes such as PDMAEMA, poly(diethylaminoethyl methacrylate), their parent acrylates and copolymers, and strong polyelectrolyte brushes such as PMETAI have been extensively investigated via ellipsometry and neutron reflectometry . Neutron reflectometry has also been applied to the characterisation of surfactant infiltration within polyelectrolyte brushes, demonstrating the change in morphologies achieved depending on surfactant concentrations, brush thickness and pH of the medium . This technique was also applied to the elucidation of the morphology of brushes upon a-lactalbumin infiltration, although the impact of brush architecture and environmental parameters were not studied .