GAPDH is found in Parkinson's Disease (PD)-associated aggregates, and its aggregation is promoted by electrophilic conjugation . Given its abundance and fold change in DNAJB8 co-IP recovery, it is possible that GAPDH is the feature observed by silver stain at 37 kDa (Figure ). Thermodynamically destabilized PARK7 variants are linked to familial Parkinson's disease , and PARK7 overexpression protects against chemical induction of Parkinson's phenotypes . Although a wide variety of mechanisms have been ascribed to PARK7, including chaperoning and proteolytic activities, the evidence is strong that it serves as an oxidative stress sensor that protects against cysteine oxidation , as well as a cellular deglycase preventing electrophilic protein damage.