There are many reasons that support the use of tetracycline family most importantly 1\they are predicted by many computational repurposing studies that predicted that tetracycline family to have an inhibitory effect on COVID-19 replication proteins, in addition to that tetracyclines have immune modulation effect. This study through pocket similarity and docking predicted that chlortetracycline to have bound to the site similar to the site that the drug bind to in the original target, and because the drug has an inhibitory effect on the original target and the pocket of the original target and the COVID19 protein are similar this lead to the fairly accurate assumption that chlortetracycline will function the same in COVID19 protein. Both tetracycline and doxycycline were predicted by PocketMatch but only Cholorcycline was able to bind to the pocket with a binding affinity less than -8.0 due to the inaccurate docking protocol, finally I recommend the tetra family for further research.