Stimuli-responsive transformation is a notable characteristic functionalizing the phospholipid bilayers for transportation. The deformation of the membranes regulates substance transportation in both directions, i.e., exocytosis, as the transportation from the intracellular to the extracellular environment, and endocytosis, as the uptake of substances from the extracellular to the intracellular environment. The two-dimensional architecture of the phospholipid bilayers also provides media for embedding proteins. The membrane-embedded proteins are the central molecules performing membrane-mediated signal transduction by sensing external signals to regulate cell growth and differentiation.