This can be interpreted such that in most cases, the molecule synthetic difficulty reduces in the hybrid reactions pool compared with the organic synthesis or synthetic biology ones alone. It also suggests that although the addition of the biological dataset only adds 0.36% data into the chemical dataset (Figure in terms of the number of reactions), in overall, it adds value by 3.4% to the organic synthesis to reach better synthetic results (by comparing the expected costs of molecule medians of 4.3 and 4.15 in organic and hybrid synthesis respectively): it is able to improve the redox efficiency and find more opportunities for synthetic shortcuts among molecules via hybridising the reactions pools.