In general, accurately ranking host-guest systems was rather difficult for most methods, even for methods that had the best error metrics. Methods had greater success at predicting the tightest binding guest for the WP6 host. Accurately predicting weaker binders remains a challenge for almost all methods as has been the case in previous SAMPL iterations. Interestingly, no method correctly predicted the tightest or weakest binders for bCD or HbCD hosts. Given that the dynamic range of experimental measurements (from strongest to weakest) for the bCD-phenothiazine dataset was less than 2 kcal/mol, greater BFE accuracy would be needed to accurately rank the complexes.