Complementary to structural fragments relevant for rdk5-LC40-RF, the top 10 pairs with a certain topological distance (e.g. 1 for AT SC1v) . As AT S0Z and AT SC1v describe small distances, they highly correlate with the molecular weight of a compound, thus low drug feeds lead to lower values for mixture descriptors of this kind. Larger topological distances consider interactions between more distant atom pairs and can detect differences e.g. between monomers (see below). Furthermore, we previously used the important descriptor SpM AD_Dt of the detour matrix, describing all atom-atom distances within a molecule , for predicting drug-lipid interactions, showing distinct values of this feature for symmetric molecules .