Under the optimized conditions, we further explored the substrate scope for the hydrogenation and HDO reaction over Pd@MOF. The C=O and -NO2 bonds of aldehydes, ketones, and derivatives of nitrobenzene were selectively and effectively transformed, affording the corresponding aromatic hydrocarbons in excellent yields (Table and Table ). Firstly, lignin-derived aldehydes and ketones were selectively hydrogenated, affording corresponding alcohols in good yields (Table ). For example, the hydrogenation reduction conversion of monosubstituted aldehydes, such as phydroxybenzaldehyde and p-anisaldehyde (Table , entry 1 and entry 2), afforded the corresponding alcohol products with excellent yields above 95%. As to substituted biomass aldehyde, vanillin transformed to vanillyl alcohol in moderate yields due to the excessive reduction of part of the product alcohol to p-methyl guaiacol (Table , entry 3). In addition, 3,5-dimethoxybenzaldehyde can be effectively converted into a hydrogenated product with excellent yields (95) (Table , entry 4).