NPD was then applied to idenNfy the presence of any new and/or modified species between the DS and four commercial DP. NPD as an additional function of the MAM monitoring phase that allows the comparison of reference material and samples using retention time, m/z and intensity threshold parameters. NPD can be used to detect new, modified, or missing components, and potentially identify impurities or modifications in samples when compared to reference material and vice versa. NPD is based on a non-targeted MS search that compares full MS data of the reference material with the analyte of interest. The NPD analysis requires to adjust and opNmize some general se}ngs which would be sopware specific. Most criNcal parameters such are RT window, tolerance (ppm) and peak intensity threshold, to reduce the detecNon of false posiNves or negaNves, always depending on the quesNon to be answer.