The Loewe-Additivity model is the mathematical starting point used to predict drug synergies . As part of the challenge data, we have information about the drug compounds and their targets. Therefore we can calculate whether the combination is synergistic or not . Since the conditions for this model are already well accepted and can be used to calculate drug synergies, this does not give many new or interesting combinations that have yet to be explored for potential synergistic effects. In this case, the established model is considered the standard that will be compared against the new models proposed. The decision was then made to try and extend the model to gene products and proteins that are biologically related, in order to find new combinations that could potentially be synergistic, without just grabbing every permutation of two drugs from the drugs used. This extension is done using biological databases such as WikiPathways, technologies like the Resource Description Framework (RDF), and SPARQL Protocol and RDF Query Language (SPARQL).