Naproxen-conjugate displays a lower Rf value, indicative of more polar behavior and a successful decrease in logP. In addition, the Rm value was calculated in gure 5 using the measured Rf value. From this value, the logP could be analytically determined due to its relation to the Rm value . The measured logP value was compared to the calculated value using the ChemSketch program of ACD/Labs, Inc . Based on both the calculated and analytically determined logP value, the Naproxen-PEG conjugate displays a decrease in logP value compared to OTC Naproxen.