Among the ADM1 parameters, only 𝑘 𝑎𝑐 (i.e., the maximum specific growth rate of acetoclastic methanogens; 𝐷 ∈ [0.16, 0.20], 𝑝 < 0.0001) was found to have significant impacts on fluidized bed systems' LC and CI. In comparison, 𝐾 𝑎𝑐 (i.e., the half saturation coefficient of acetate) had significant impact on packed bed systems' rCOD (𝐷 = 0.13, 𝑝 < 0.01) but not on LC or CI. rCOD was also mildly sensitive to variations in 𝑘 𝑑𝑖𝑠 (i.e., the 1 st -order kinetic rate constant of particulate disintegration; 𝐷 = 0.12 or 0.16, 𝑝 < 0.01), but the effects were not strong enough to drive the LC or the CI of COD removal given uncertainty in other technological assumptions and design decisions. Nevertheless, these parameters should be prioritized for ADM1 calibration in future work to provide more accurate evaluations of the COD removal and methane production performance and to enable overall sustainability assessments of encapsulated anaerobic systems for similar applications. reasonable maxima) for bead lifetime and 𝑘 𝑎𝑐 (Figure ), and the HRT that yielded the lowest CI for packed beds was determined across the uncertainty space for bead lifetime and bead-to-water diffusivity ratio (Figure ). HRT was bounded between 1 hr and 5 days and fluidized-bed bead volume fraction was constrained between 0.03 and 0.25. To maximize specific interfacial area for mass transfer, both systems were assumed to use 1-mm beads, which is the lower bound for bead sizes seen in wastewater-related applications in the literature. For packed bed systems, loose packing (i.e, voidage = 0.45) was assumed.