We noticed that N protein could form a multimer, S protein could form a trimer structure, and E could form a pentameric channel structure. The ORF3a protein and ORF8 protein can form a dimer structure, respectively. The dimer of ORF3a protein (or ORF8 protein) has a groove structure. The Ig-like sites of the ORF3a protein do not fully overlap with the MHC-like areas (Table and). However, Table shows that the MHC II and MHC I of ORF3a are located at the "CWKCR" heme-binding area and upstream and downstream. But the sites of MHC structures are not near the groove structure on the ORF3a crystal structure view (PDBID: 6xdc). Therefore, ORF3a is unlikely to have the ability to bind antigen peptides.