Different NCPs are connected by linker DNA composed of 38-53 base pairs. The structural properties of packed DNA in the NCP differ substantially from those of bare DNA . In view of the fact that in NCPs the electrostatic environment can differ largely from the one of free DNA, with DNA strands (presenting negatively charge phosphodiester backbones) tightly wrapped around highly basic (i.e. positively charged) histone proteins, the same could also hold for the electrochemical properties and thus the redox chemistry and ability to conduct holes of free (unpacked) DNA in aqueous solution, and the potential effect of a defect base could significantly differ when DNA is in its packed state. Some attempts to investigate DNA-mediated CT in chromatin have been reported in the literature. However, the resulting evidence is contradictory and inconclusive, possibly because of the variety of different donors and acceptors used in the respective experimental setups making it challenging to directly compare studies and disentangle effects due to the specific redox probes used from the effects due to intrinsic redox features of chromatin. Some of these works also suggest that the efficiency of hole transport and the potential of observing oxidative damage in G-rich sequences depends on the exact position within the NCP with respect to its exposure to the solvent or the histone environment. Additional investigations, which focus on the potential repair of 8oxoG or a uracil mismatch within the NCP, indicate a decrease in repair efficiency for defects within regions facing towards the interior histone proteins and away from the solvent-facing surface, up to an order of magnitude in the case of uracil mismatch repair. Evidence from many of these studies indicates that BER enzyme binding accessibility is greatly modulated by local chromatin structure.