In summary, we have developed an iron-catalyzed threecomponent reaction that utilizes N-vinylphthalimide as a lynchpin. The reaction tolerates a variety of aryl Grignard reagents and fluoroalkyl bromides. The use of a removable phthalimido group can provide an efficient strategy to prepare highly valuable g-difluoroalkylated amines. The reaction can also extend to different ring sizes of N-vinyl lactams, N-vinyloxazolidinone and N-vinylacetamide. Further studies to develop catalytic asymmetric synthesis are in progress in our lab and will be reported in due course.