To demonstrate the utility of our new reaction system, we deployed the methodology towards the synthesis of the alkaloid natural product (±)-laudanosine 57. 57 has structural similarities to compounds in reaction scope investigations (e.g. 41). It is a metabolite of two approved drugs, atracurium and cisatracurium, and is naturally found in small amounts in opium. To prepare laudanosine, 3,4-dimethoxyphenethylamine 58 was protected with methyl chloroformate 59 to generate carbamate 60. This intermediate was simply purified by washing with water. Condensation and cyclisation with glyoxylic acid in acetonitrile with just two equivalents of trifluoroacetic acid afforded the required carboxylic acid 61 which was coupled with 4-(bromomethyl)-1,2-dimethoxybenzene 62 under the optimized conditions, using an adjusted water loading of 15 equivalents, to generate 63 in 83% yield. Finally, the carbamate functionality in 63 was reduced with excess LiAlH4 to generate the N-Me moiety found in (±)-laudanosine 57 in 93% yield. Our total synthesis of 57 in 67% overall yield over four steps compares favorably to the total syntheses by Jangir et al. (five steps, 43% overall yield) In conclusion, we have developed a new approach to generate Pictet Spengler-type reaction products via a visible-light mediated metallaphotoredox catalytic cycle. This operationally simple method tolerates a broad range of functionality of both coupling partners. More importantly, the new process is a distinct synthetic strategy that can generate bioactive products that would be difficult to access via existing methods.