Here, parameter p controls the weighting of the deviations from the reference states. A greater value of p provokes more localized events dominated by a small number of CVs with large distortions, whereas a smaller value of p leads to more concerted reactions inuenced by more of the n CVs. Due to the limited description of the conguration space by a single set of CVs, redenition of the CVs is generally required when the system reaches a new state after a transition, i.e. reaction. Therefore, a criterion of the occurrence of a transition and the following change in the reference state is needed, which is dened here based on the global distortion. In case of possible transitions, the global distortion should take a value equal to or greater than a predened value X cut .