A sensitivity analysis is conducted to explore the effect of regional differences on CNC production by placing CNC plants in Alberta (CA), Wisconsin (US), Tianjin (CN), and Sweden (EU). These regions currently host commercial-scale CNC producers as shown in Figure . In the analysis of different regions, electricity is sourced from the local grid mix; raw materials are preferably produced locally, or transported from other regions if no relevant data is available in the database. No production information was found for NaOH in the Ecoinvent database. To resolve this, we used the global market for NaOH (a market process is recommended when production process cannot be specified ). Overall, the regional differences are summarized in Table . + RoW: when an activity exists in globally and locally, rest-of-world (RoW) refers to the global minus all local geographies in Ecoinvent .