With this small and efficient library at hand, showing the promise of the "sociability-first" concept, we will transfer it to various other libraries. Using the entire REAL Space allows for even more diverse fragments and follow-up compounds and the design of more extensive libraries suitable for higher-throughput methods. Furthermore, this concept can be easily applied to libraries specialising on different concepts and screening techniques (covalent binders, natural product-likeness, high sp 3 -fraction, minifrags or 19 F fragments). Fluorinated and covalently modified analogues are readily available from Enamine's in-stock screening collection.