In this study, we have compared ∆∆G values obtained using RESP charges for ligands with those using AM1-BCC charges. For this, we use the same two mutually exclusive subsets of 30 randomly selected ligand pairs that have been used to study the effect of REST2. Figure displays the results obtained using both these charge models. Overall, the performance is almost the same with MUEs and RMSEs differing only by 0.01 kcal/mol and 0.07 kcal/mol, respectively, and r p differing by 0.01 for the combined set of 60 ligand pairs. When the two subsets are assessed separately, the performances are comparable for the 'rand2' subset with RMSE and r p slightly different for the two charge models. For the 'rand1' subset, AM1-BCC charges perform slightly better in terms of RMSE and r p than RESP. However, we cannot simply conclude that AM1-BCC charges are better than RESP charges based on this.