Among various high-yield conditions during the condition optimization of diol oxidation, Experiment Designer selected the conditions used in 35 th experiment for scaling up (Fig. ). The choice of reaction conditions was made based on the preference to the high product yield, short reaction time, and low catalyst and reagent costs. The 35 th experiment used a 45-minute reaction time, Cu(OTf)2 catalyst, and 1.34 equivalent DBU base, achieving a high yield of 94.5% (Fig. ). To showcase LLM's ability to facilitate reaction scale-up, Experiment Designer accurately calculated the stoichiometries of the reagents based on selected the reaction condition to produce 1 gram of the desired product (Fig. ). We conducted the scale-up experiment according to the stoichiometries proposed by Experiment Designer.