As part of our overarching strategies to synthesize a diverse range of diarylated-based bioactive compounds (1-8, Figure ), encompassing diarylmethane and diarylketone derivatives, we identified organophosphonium salts (i.e., 11) as versatile core scaffolds for these molecules (Figure ). Organophosphonium salts, characterized by the presence of C-+ P moieties, particularly organophosphorus-based Wittig salts, are among the most widely utilized reagents in organic synthesis for constructing C-C double bonds. In recent years, innovative methods for functionalizing the C-+ P bond have emerged, employing organophosphonium compounds in novel ways to enable the formation of new chemical bonds such as C-O, C-N, C-S, and C-C bonds. These advancements underscore the importance of exploring additional methods for the synthesis and functionalization of organophosphonium species. Such efforts hold the potential to significantly expand the toolbox for derivatizing noble organophosphonium salts and facilitate the creation of new molecular connections. (12) and diarylketones (14). (C) Our proposed approach: The synthesis of phosphonium salts and their modification through a C(sp 3 )-+ P bond reduction and oxidation, enabling the production of unsymmetrical (deuterated) diarylmethanes (12, 13) and diarylketones (14).