The quality of a docked pose was assessed by computing the root-mean-squared deviation (RMSD) of the coordinates of the atoms of the ligand's docked pose with respect to the coordinates of the ligand's atoms in the crystallographic pose. To ensure we correctly accounted for symmetry when computing the RMSD between two conformers, we identified symmetrically equivalent permutations of the atomic indices of a molecule by performing a substructure match of the molecule against itself using RDKit version 2019.09.1. We then applied these permutations to the indices of the atoms and re-computed the RMSD of the docked and crystallographic structures for each permutation. The lowest computed RMSD value was then taken as the RMSD of that docked pose.