Catalyst design. The use of computers for asymmetric catalyst design has been a very promising field for two decades. For example, as early as 2003, Kozlowski and co-workers developed a model based on interaction fields (see Box 2) for dialkylzinc addition to aldehydes catalyzed by β-amino alcohols and applied it to identify novel catalysts. However, unexpectedly, twenty years later, while more validated methods are now available to the organic chemistry community, the applications to new catalysts design by groups other than the developers are still scarce.