Conclusion, we have established a mild, simple and convenient method for synthesis of ester compounds by using DBU in anhydrous DMSO at ambient temperature. This methodology was very effective in synthesis of ester in presence of other sensitive functional groups such as trithiocarbonate, dithiobenzoates, nitrile, halo groups. The reaction was found to be general applicable to aliphatic and aromatic compounds. The notable advantage of this methodology is mild conditions, industrially applicable, tolerance to a wide range of functionalities. We believe this will find significant application in the field of organic synthesis.