Hundreds of drug-like non-toxic low-µMolar affinity children with high vapor pressures have been computationally predicted by improvements of previously described hit compounds by targeting Anopheless ORCO monomer new cavities by DWBEL co-evolution, EPI MPBPVPWIN™ VP predictions and ADV docking. The new candidates cross-docked the same α-helices than previously reported to bind ORCO antagonists, but with ~ 10-100 fold higher docking affinities. These high number of candidates may offer further research to in vivo evaluation of their possible anti-mosquito activities. Combinatorial chemical synthesis may help to provide the required chemicals for experimental evaluations. The recent availability of ultrasearch technologies targeting extralarge chemical spaces generated by virtual combination of fragments for easier chemical synthesis, is encouraging. Alternatively, chemical analogues to test for any of their possible high-docking affinities could be also searched for experimental purposes.