Ten model replicates were trained for each protein descriptor benchmarked with random seeds 1234, 2345, 3456, 4567, 5678, 6879, 7890, 8901, 9012, and 9999. The statistical significance of the differences in performance when using different protein descriptors was calculated by performing an independent T test of the average performance metrics in the pool of model replicates. Differences were considered significant when p-value < 0.05.