, and free energy is supplied to the motor by the fuel-to-waste conversion. The chemical gating in the fueling reaction arises due to the steric crowding in transition states of the proximal co-conformers (1 evolve towards a stationary state in which the concentrations of all the motor species (i.e., all co-conformations and chemical states of the motor) are constant in time, as are the thermodynamic properties of the system. The entropy production rate (the entropy changes in the system and in the reservoirs per unit time) denoted Σ measures how far from equilibrium the motor operates and has to be non-negative by virtue of the Second Law of Thermodynamics. When multiplied by temperature (T ) it corresponds to the amount of free energy that is instantaneously dissipated by the motor (T Σ). In a stationary state, the only kind of state that will be considered in this paper, all the free energy from the conversion of the fuel-to-waste is dissipated by the motor: T Σ = I F (µ F -µ W ) ≥ 0, where I F is the rate at which the fuel is consumed by the motor (we neglect the fuel-to-waste background reaction). This indicates that a non-null chemical potential gradient between fuel and waste species (we consider the case where µ F > µ W ) is necessary to drive the system out of equilibrium, and produce directed motion. However, this expression gives no information as to how free energy is consumed nor the amount of dissipation specifically devoted to sustain directional motion of the components.