Since the reaction simulation is capped by both molecular weight and the number of generations that can be explored for computational reasons, the analysis in Figure is biased in various ways. Furthermore, since kinetics are not considered in the CRNR, the relative importance of highly connected species cannot be assessed using these methods. This ranking thus only illustrates that small achiral aldehyde and ketone functional group-containing intermediates likely have the greatest power to enable stereochemical amplification in the FR.