Concerning protein classification, enzymes represent nearly half of the classified and annotated proteins, with more than 25 million data points, and membrane receptors 21% with more than 11 million (Figure ). Family A G protein-coupled receptors represent 37% of proteins annotated with a second level class (Figure ), consisting in more than 9 million datapoints, proteases 23%, more than 5 million, and kinases, long thought undruggable targets, represent 18% of the data with more than 4.5 million datapoints.