We selected 5 molecule sets, where each molecule set contains ligands from one of five di erent targets from the Open Force Field Project's ProteinLigandBenchmark (PLB) repository, to use in our study. Four of the five molecule sets -HIF2a, P38a, PTP1b, SHP2 -were chosen based on poor performance in previous benchmarks performed by the Open Free Energy Project suspected to be caused by di erences in partial charge assignment across repeats. The final molecule set, tyk2, was chosen due to the fact that it is normally wellperforming with small variation across identical repeats. Open Free Energy's benchmarks of these systems resulted maximal variations of 0.38 kcal/mol across repeats for each molecule in the tyk2 set. These combined systems resulted in a set of 126 molecules.