The synthesis of CyP-OBu is depicted in Scheme 1. Starting from the MOM-protected aryl-gpyrone 2 previously described, the alkyne 3 was prepared in 47% yield via aldolization/crotonization reaction in presence of vanillyl butyl ether 1 and sodium ethoxide. A subsequent acidic deprotection of aryl-g-pyrone moieties provided the target CyP-OBu derivative in excellent yield, which was fully characterized by NMR spectroscopy and HRMS, confirming its molecular structure. Scheme 1. Synthetic strategy for the CyP-OBu preparation.