In the present work, we assess if synthetic accessibility scores can reliably predict outcomes of retrosynthesis planning. We also analyze if synthetic acces-sibility scores can speed up the retrosynthesis planning by reducing the size of the search space. Specifically, we analyze the outcomes and runtime of the retrosynthetic tool AiZynthFinder on a specially prepared compounds database. We assess if four scores: SAscore, SCScore, RAscore, and SYBA (cf. Table ) properly predict the results of retrosynthesis planning and the search complexity. To do this, we analyze the AiZynthFinder partial solutions search trees. Moreover, by in-depth analysis of these search trees, we assess if synthetic accessibility scores can speed up retrosynthesis planning by better prioritizing partial synthetic routes.