Numerous Ebola patients have an electrolytic environment deficient in potassium and require potassium supplementation via oral and intravenous routes . Children with severe Ebola virus disease have hypokalemia, which can be treated with intravenous and oral potassium . Patients with Ebola continued to experience diarrhea throughout their stay, resulting in significant loss of bodily fluids, necessitating ongoing IV potassium chloride infusions . Severe hypokalemia manifests in EVD by overall lethargy and tiredness, muscle necrosis, reduced respiratory function, and dysrhythmia induced by upper paralysis . While hypokalemia is common in people with Ebola, severe hypokalemia and hyperkalemia are uncommon . It shows a portion of potassium may be excreted in bodily fluids such as diarrhea and urine. The Ebola virus may also utilize another portion of potassium. When the Ebola virus enters the cell, potassium enters the vesicle by the cell's endocytosis. When the endosome releases virus nucleic acid, the endosome's potassium is released into the cytoplasm via potassium ion channels, which participates in the virus replication process. In other words, when the body is infected on a broad scale, a large amount of potassium is introduced into the cells. The results in an abnormally low potassium level in the blood. Beside, the Ebola virus proteins blocked potassium flow from the intracellular to the serum or body fluids along potassium gradient by the LCN type CS-α/β domain. Potassium is crucial in the virus's release process. The potassium may be release outside the cell to maintain the conformation of structural proteins such as S. When a large amount of virus is released into the blood or the body fluid, extraordinarily high blood potassium levels are likely to occur.