The discovery and design of polar organic cocrystals face several fundamental challenges at both the molecular and practical levels. At the molecular level, organic compounds inherently tend to crystallize in centrosymmetric space groups, which lack the directional asymmetry necessary for polar properties. Our statistical analysis of the Cambridge Structural Database (CSD) reveals that only 13.9% of organic cocrystals exhibit polar symmetry, underscoring the intrinsic difficulty in achieving these arrangements. This challenge arises from the complex and often unpredictable interplay of molecular interactions that govern crystal packing and organization. While several key factors influencing cocrystal formation, such as hydrogen bonding patterns , supramolecular synthons , and the physicochemical properties of the constituent molecules, have been identified, specific principles governing the emergence of polar arrangements remain poorly understood.