Studies have shown that charged nanochannels exhibit selective transport of molecules based on the surface charge and its interaction with the transported species. Notably, the release exhibited a marked dependence on pH, showcasing a highly quantitative response. However, a striking shift occurred at pH 5.0, significantly increasing CV+ release, MCM-Z (68%), and MCM-ZD (74%). These results highlight the pH-tuned delivery potential of these materials for applications like controlled molecule delivery. This pH-controlled release mechanism highlights the potential of charged nanochannels for controlled delivery applications. for MCM-Z, regardless of temperature (37-47°C). These findings suggest that both materials exhibit promising pH-controlled release properties, with potential applications in drug delivery systems where targeted release at specific acidic tumor environments is desired.