The component and composition of samples are shown in Tables and. S-892216 drug substance or amorphous solid dispersion, mannitol, microcrystalline cellulose, croscarmellose sodium, and magnesium stearate were mixed using a mortar and pestle. The mixture was sieved through a 20-mesh screen and, subsequently, compressed for dry granulation (slugging) using a single-station tablet press (Ichihashi Seiki Co., Ltd., Kyoto, Japan) with a flat-faced punch (diameter = 15 mm). The slug weight was adjusted to 500 mg and compressed at the pressure of 12 kN. The slugs were sized using a 20mesh screen. Magnesium stearate was added to the milled granules. The mixture was lubricated by hand shaking in a glass vial. The final blend was filled into empty capsules by hand or compressed using a single-station tablet press with a round-shaped punch (diameter = 8 mm).