Basically, only the information about the examples of proteases potentially involved in cleavage is available. To our best knowledge, there are no in silico studies attempting to explain this process. We are aware that one of the obstacles may be the size of the system and that no accurate structure predictions of the TLR-protease complex have been available so far. However, we hope that with the increase of the computational resources and the possibility to predict the structure of complexes using e.g. AlphaFold Multimer, this issue will be soon addressed.