Cannabinoids are substances that are found in cannabis and can interact with the endocannabinoid system. One of the most well-known cannabinoids is Tetrahydrocannabinol (THC). This substance interacts with the endocannabinoid system and affects different parts of the body. This system contains two receptors: CB1 and CB2. Whereas CB1 receptors influence motor control, thinking, motor coordination, and related functions, CB2 receptors usually influence the gut, kidneys, pancreas, and related organs . The CB1 receptors are located in different parts of the CNS such as the cerebral cortex, amygdala and hippocampus. THC is known to affect dopamine, a neurotransmitter needed for motor control, arousal and more. Dopamine is a monoamine neurotransmitter, which is known to play a role in executive function, motor control, motivation, arousal, reinforcement, and reward. Dopamine release can be stimulated by conducting pleasurable behaviors. This causes the adrenal gland, which is located above the kidneys, to release dopamine. There are four major dopaminergic pathways, the mesocortical pathway, the nigrostriatal pathway, the tuberoinfundibular pathway and the mesolimbic pathway . Dopamine has a number of essential functions in the brain. In particular, dopamine released from the midbrain plays a crucial role in the mammalian central nervous system. Dopamine is known to have a total of 5 receptors which are divided into two main functional categories.