Phase/LigPrep and Glide from Schrödinger Suite 2023-4 were used for SMILES to 3D structure conversion and the docking calculations. SpaceLight version 1.3.0 and FTrees 6.11.0 from BioSolveIT were utilized in the chemical similarity searching of the nonenumerated chemical spaces. The similarity threshold for SpaceLight was set to 0.5 and a value of 0.9 was used for FTrees calculations. The maximum number of retrieved compounds was set to 10,000 for both tools. With these settings, the search time for each query varies from a few minutes to little more than an hour. This variation comes mainly from the differences in queries, not the hardware.