The TTT-children predicted two main chemotype top-leads displaying one common central core of 6-atoms and three variable atom branches containing one 6-carbon ring each. The results confirmed that any other possible cores displaying lower numbers of atoms were again not selected by the evolutionary docking when extending random variations to any of the atoms of the initial parent. One of the top-lead 6-atom chemotypes contained cores with two Nitrogens (Figure ). Red spheres, Oxygens. Blue spheres, Nitrogens and yellow spheres, Carbons. Their unique identification numbers were automatically assigned by their generation order from the parent during evolution. Horizontal dashed gray line, DW docking-score of the TTT-parent. Gray, TTT-parent profile fitted to <500 Dalton, logP<2, ring-count <4, Nitrogens<6, Oxygens<6 Blue, TTT 4976-children profile fitted to <550 Dalton, logP<2, ring-count<4, Nitrogens<3, Oxygens <9 Green, TTT 9990-children profile fitted to <550 Dalton, logP<2, ring-count<4, Nitrogens<3, Oxygens <9 predicted lower DW and ADV docking-scores, lower hydrophobicities, and higher specificities, despite their slightly higher molecular weights (Table ). The 9990child predicted a higher number of hydrophobic contacts and one Hydrogen bond compared to the TTT-parent (no Hydrogen bonds) and to the 4796-child (two Hydrogen bonds) (Table ).