The number of possible networks is vast. For this dataset there are 16 14 =7. ). This protocol leads to significantly more accurate results with low uncertainty (R ∼ 0.9, τ ∼ 0.72, MUE ∼ 0.45 kcal•mol -1 , n = 22) and represents near optimal results that may be achieved with the RBFE protocol used here to process each edge of the network (Figure ). This optimal network allocated 22 edges to the TYK2 dataset.