Various SPARQL queries were executed to explore parts of the data and utilise the interoperability of RDF by performing federated SPARQL queries with the AOP-Wiki, which contains more extensive information about the AOPs that are initiated by some of the ENMs. First, general information is queried about the presence of ENM types, their physicochemical characteristics, and the MIEs that were annotated for all ENMs. One of the MIEs, DNA damage (), was selected as a use-case for further exploration because the RDF contains sufficient information for this case, but DNA damage as MIE or KE is a rather specific effect and not a side product of various mechanisms of action. Using the RDF, the MIE of DNA damage was linked to material types and physicochemical characteristics, and potential AOs that can be caused by DNA damage were explored by including information contained in the AOP-Wiki RDF (33).