The synthesis of hydrazone is a simple and straightforward reaction that we used to demonstrate the use case of performing calculation using GPT-4. In the general procedure of hydrazone synthesis, the amount of aldehyde is given in moles and equivalent to accommodate the various aldehyde species. Using 4-fluorobenzaldehyde as a test case, GPT-4 successfully outputted the correct molecular weight and calculated the correct mass of 4-fluorobenzaldehyde, see Fig. . Note that the identified step 3 involves both temperature and stirring information as these two steps are described in one sentence with no additional ramping instruction, like case study 1. Despite the identified single-step action, the output from second prompt successfully transcript this step to HeatCool and Stir operations. The complete response generated by GPT-4 and the experiment design XML are in ESI † Table .