DNA nanotechnology has opened a new era in smart diagnosis, bioimaging, and treatment, thus designing smart delivery vehicles with DNA nanomachines. DNA nanomachines, which are nanostructures that can move at the nanoscale , offer unique advantages like easy synthesis, thermal stability, and functionality . They are promising for applications in biosensors, drug delivery, and molecular computation . Several types of DNA nanomachines have been designed with nanoscale control and biocompatibility, including DNA walkers , DNA motors , DNA gears , DNA nanocages , and DNA tweezers . In recent years, there has been a notable increase in research and development efforts focused on dynamic DNA origami devices, which exhibit the capacity to switch among multiple stable or semi-stable states. These structures vary in the way they are triggered, the number of states they can access, their speed, and whether the transitions can be reversed .