The present investigation found that tau protein synthesis directs the RAN sequence, following the fragment downstream of the transposed telomeric fragment. The dimeric tau protein binds to the transcription factor structural region. The guide RAN sequence places one subunit in the complementary intron region, and the "TAA" position of the TATA-BOX or enhancer (Homeobox, MADS-box, HMG box) houses the other subunit. Mutations in the intron region of genes that act on the Aging Device, such as point mutations, insertions, or deletions, clearly compromise the localization of the dimeric tau protein. In other words, the Aging Device function of the tau protein is unable to perform telomere transposition at the gene, resulting in a lack of reduction in the number of gene copies. If a intron mutation (e.g., point mutation, insertion or deletion mutation) occurs, the dimeric tau protein will abnormally localize in the intron region of genes that do not act on the Aging Device. In other words, the aberrant inactivation of certain genes will result from telomere transposition in genes that do not interact with the Aging Device.