Rosette nanotubes (RNTs) were first developed in the early 2000s, and have subsequently shown to encapsulate and release various hydrophobic drugs in physiological environments. Although they are synthetic, RNTs are biomimetic and are self-assembled by a hierarchical and entropically driven process. The nanotubes self-assemble into stacked rings or a helical tube with building blocks of DNA-derived guanine (G) and cytosine (C) in a G∧C unit, as shown in Figure .