One of the annotations merits a brief elaboration. In addition to the widely used though increasingly controversial PAINS filter matches, we have annotated all SAVI products with a score based on 275 rules for identifying potentially reactive or promiscuous compounds that might interfere with biological MN-10 assays. We believe that these rules, described by Bruns and Watson as being based on years of assaying experience at Eli Lilly, have more relevance and greater discriminatory and predictive power than the PAINS filters. All 275 rules have been implemented in CACTVS specifically in the context of the SAVI project (with help from Ian Watson), to produce an overall score called "Bruns and Watson demerit" (the lower the value the better).