However, when the number of torsion points increases, the number of different conformations to assess exponentially grows. For instance, a simple flip (180° rotation) around a single bond creates 2 possible conformations to evaluate and if there is 6 such torsion points in a small molecule, a total of 2 6 =64 calculations (minima on PES) must be completed to find out the lowest energy (global minimum) and other low lying (local minima) structures. For that reason, most of the conformer generation algorithms use stochastic search algorithms rather than systematically evaluating all conformers.