Although these methods clearly afford important and convenient new methods for arylative C-C bond-formation, the catalytic asymmetric arylative radical cross-coupling is still confronted by several challenges: (a) the scope of the radical precursors is typically limited to activated alkyl halides; (b) almost all the asymmetric three-component variants involve vinylarenes as acceptors to enable the radical relay event, thereby restricting the scope of the reaction and thus its impact and utility in the context of target molecule selection; (c) Despite the fact that these mostly used chiral bisoxazoline ligands or anionic N-ligands can provide good stereocontrol in the arylation step, the inherent redox potential window of copper and nickel-based complexes poses a limitation on the scope of radical precursor. In accord with our work on developing light-mediated copper-catalyzed cross-coupling reactions, we reasoned that ligand tunability and/or visible light irradiation would probably provide new opportunities for developing generally applicable copper catalytic system for multicomponent arylative radical cross-coupling (Figure ). This enabling catalytic system would allow to address the inherent complexities associated with balancing efficiency of each step and chemo-and stereoselectivity control. Herein, we disclose the implementation of this design strategy into an experimental reality, by developing a general copper/bisoxazoline catalytic paradigm to enable the enantioselective three-component arylative radical cross-coupling of vinylarenes and 1,3-enynes (Figure ). This protocol features redox-neutral conditions, excellent substrate scope of readily available starting materials and high functional group tolerance to provide facile and divergent access to a variety of enantioenriched and high-value (hetero)aryl-substituted molecules. Note that our arylative protocol provides the first example of 1,3-enyne-based asymmetric arylative radical cross-coupling.