As shown in Figure , the wingless-related integration site (Wnt) pathways play a complementary role in bone remodeling by regulating osteoblastogenesis . Wnt is a family of 19 glycoproteins that can activate the canonical Wnt/β-catenin pathway, the non-canonical Wnt/Ca 2+ pathway, and the Wnt/planar cell polarity pathway . Wnt ligands, such as osteoclast-derived Wnt-3a and Wnt-10b, activate the canonical pathway by binding to low-density lipoprotein receptor-related protein 5 or 6 (LRP5/6) and the Frizzled coreceptor . This increases β-catenin levels, upregulating osteoblastic genes . The canonical pathway promotes mesenchymal stem cell differentiation into preosteoblasts by inhibiting their differentiation into adipocytes and chondrocytes .