The standard model predicts some of the ring forming reactions that appear in the 'Ring Breaker' predictions with a lower rank, as would be expected due to the greater number of transformations on which the standard model is trained. The additional reactions on which the standard model is trained offer alternative approaches to access ring systems that do not necessarily involve ring formations, such as functionalization of the core scaffold (Figure ). These approaches can be used for known ring systems, however, for novel systems that have not been observed before, the ring system must be built from basic building blocks. The prediction ranked number seven for the ring system in Figure is based on a template extracted from the reaction shown in Figure . The template predicted by the model is precedented for a benzene ring and applied on a pyridine for which the nitrogen atom falls outside the templates scope, thus the template can be applied in a different context in silico.