Normal-phase HPLC was carried out on an Agilent 1100 series system (USA) equipped with a G1379A degasser, G1313A binary pump, G1367A well plate auto sampler, G1316A temperature-controlled compartment and a diode array detector. For chiral analysis a Daicel (Osaka, Japan) CHIRALPAK® AD-H column (particle size 5 μm, dimensions: 4.6 x 250 mm) was used: 4.6 nm diameter and 250 mm length. Injection volumes of 10 μL were used and the DAD detector recorded absorbance at 254 nm. Substrates and products were eluted over 20 minutes using an isocratic method 10:90 (Hexane:IPA 0.1% DEA). Peaks were assigned by comparison to to chemically synthesized standards or analysis of MS data and the peak areas were integrated using Agilent OpenLab software.