Current synthetic nanomotors fall far short in autonomy and sophistication when compared to their biological counterparts. Biological motors exhibit impressive energy conversion, selfregulation, adaptability to environmental changes, along with intricate collective behaviors like bacterial chemotaxis, properties that the artificial nanomotors aim to replicate. To advance the design of synthetic active systems, it is crucial to integrate more functionalities and establish a "division of labor" among specialized components. Similar to "Systems Biology," which involves interactions across various length scales from cells to tissues to entire organisms, the concept of "Systems Materials" can be applied to interacting materials, ranging from the molecular scale to the macroscale (Fig. ). For instance, how does nanoscale motion of components lead to macroscale effects? Understanding the behavior of interacting units requires an integrated systems approach that considers the individual components, their energy sources, and the medium in which the system operates.