Having established optimized conditions, we systematically investigated the generality of the hybrid palladium-catalyzed 1,4-difluoromethylamination of nucleophiles (Scheme 1). A diverse array of nitrogen-based nucleophiles underwent examination, revealing the robust versatility of the reaction across the spectrum of employed amine substrates. This encompassed Scheme 1. The scope of nucleophiles. [a] both benzisothiazole (13c), pyridine (14c), and thiophene (16c), all amenable to the standard conditions. Notably, both primary and secondary amine functionalities were accommodated, highlighting the transformation's versatile nature. Furthermore, the resilience of alcohols (19c and 22c), the NH group within amide (17c) and terminal alkyne (32c) was evident, as they remained inert to direct carbene-mediated engagement with Freon-22. Intriguingly, the nucleophilic scope extended to include both sulfur-and carbon-based nucleophiles. Employing a variety of sodium arylsulfinates featuring diverse electron-donating and