CTZ is an imidazole derivative with antifungal activity. It is used for the treatment of various infections like pityriasis and vaginal yeast infection . The estimation with Ra displayed the following decreasing order of compatibility, i.e. pBuOzi > pPrOzi ≈ pPentOx > pBuOx (Figure ). Our experiments showed that the CTZ is essentially insoluble in plain water (Table ). The formulation experiments revealed A-pPentOx-A to be the best solubilizer for CTZ. At the highest tested feed ratio of 10 g/L, the formulation was completely clear and all of the added drug was solubilized (LC ≈ 50 wt.% and LE ≈ 100%) (Figure ). In contrast, the A-pPrOzi-A was found to be the least efficient in solubilizing CTZ and at all tested CTZ feed ratios, solubility fell below 0.2 g/L. Catenacci et al. recently reported the CTZ loaded hyaluronic acid capable to solubilize 0.018 g/L CTZ [71], 3.5 orders of magnitude lower compared to the apparent solubility achieved here. Again, the CTZ formulation results obtained are completely opposite to the compatibility estimation, where a similar level of compatibility for A-pPrOzi-A/A-pPentOx-A was observed. The A-pBuOx-A and A-pBuOzi-A showed intermediate solubilizing capacity for CTZ i.e. 2.6 and 4.4 g/L, respectively and with the increasing drug feed minor increase in solubility was observed.