In the gel phase and dissolu on medium, the water concentra on con nues to overall trend upwards and the polymer concentra on trend downwards along the x-axis, for all me points up un l and including 10 min, consistent with water penetra on into the film and polymer dissolu on into the buffer. However, there are strong concentra on fluctua ons in these upwards and downwards trends along the x-axis for the buffer and polymer, respec vely. Furthermore, the RTV concentra on coefficient shows opposing fluctua ons in comparison to the polymer. These fluctua ons in the gel are evidence of water-induced drug-polymer phase separa on.