To round out the SAR we investigated the addition of a methylene between the carbonyl of the amide and the pendent phenyl group on AC activity. Two analogs, 3-F ( ) and 3-methyl (36) substituted phenyl rings, were combined with the methylene insertion. However, in each case it was observed that the methyl insertion reduced AC1 potency by about 10-to 20-fold compared to the matched molecular pair for each analog. To summarize, the SAR for AC1 potency and AC8 selectivity favored small, alkyl substituents over halogenated analogs for both activity metrics. Increased alkyl branching generally led to both reduced activity against AC1 and selectivity over AC8. Polar functional groups were tolerated but displayed reduced AC1 potency with the exception of the 4-hydroxy, which was the only substituted phenyl analog to display a complete loss of AC1 activity.