The percent conversion to the product over reaction time is shown in Figure with the reaction using DABCO as catalyst in grey and M19 in orange. As described in subsubsection S6.2, the rate constants k are obtained by fitting to data points within the first 1.5 h of the reaction due to the incorporating of deuterium into the α-position of MA over the course of the reaction as described by Plata and Singleton . The deuterium incorporation can be seen in Figure The α-deuteriated MA is expected to yield the product significantly slower due to the kinetic isotope effect and the involvement of this atom in the rate-determining step of the reaction in TS3. The predicted conversion can be calculated using Equation S3 and is shown as dashed lines in Figure . The corresponding third-order rate constant k