The standard hydrothermal procedure for the synthesis of this MOF shows that, although synthesized in pure water, a higher temperature (i.e., 180 • C) is required to dissolve the porphyrin and allow it to react with the aluminium precursor. Using a mixture of water and another organic solvent could help the porphyrin to dissolve, whilst retaining the high heat capacity of water which seems to be required to form the MOF. Solvothermal reactions with different H 2 O:DMF ratios (i.e., 20:80%, 50:50%, and 80:20%) were carried out (see supplementary information for experimental details) and the optimal results were obtained with a 80:20% H 2 O:DMF ratio (Table and Figure ). DMF is a common solvent for MOF synthesis, due to its high dielectric constant and relatively high boiling point. It is interesting to look in some detail at the second generation of experiments that were proposed by SyCoFinder's algorithm. In the first generation, DMF was included as additional organic solvent, yet the second generation of reactions did not include any experiments with DMF. This is due to the fact that the crystallinity of samples with DMF are poor, and the other solvents yielded higher crystallinity. The analysis of the data shows that the solvent type, which we characterize by the boiling point, is one of the key variables that determine the crystallinity. The data also show that, although the type of solvent is important, the quality of the crystals does not linearly correlate with the boiling point. Yield might be better described by this factor: higher boiling point solvents (i.e., DMSO) show a much lower yield, while lower boiling point solvents (i.e., EtOH) show a higer one (Figure ).