As an alternative, transmission electron microscopy (TEM) has thus proven invaluable for studying MOFs as TEM accommodates micro and nanocrystals, sidestepping the need for the larger crystals typically demanded by X-ray methods. While high-resolution TEM imaging and electron diffraction methods have been successfully used on MOFs , the beam-sensitive nature of many MOFs, such as ZIF-8, poses challenges. To help overcome this hurdle, TEM's low-dose imaging and cryogenic settings can be used to mitigate radiation damage. Microcrystal electron diffraction (MicroED), a specialized cryoEM technique within the TEM umbrella , brings additional advantages. This methodology has been applied to a wide variety of samples, from biological macromolecules to small molecules and materials. MicroED employs ultra-low electron doses and cryogenic conditions to preserve the native state of beam-sensitive samples and reduce the effects of radiation damage . Coupled with rapid data collection and electron counting cameras, these features facilitate high-resolution structure determination while minimizing radiation-induced alterations. MicroED was previously applied to ZIF-8, resulting in a 0.87Å structure from a single nanocrystal, thereby demonstrating the applicability of the technique to the study of beam sensitive MOFs .