In order to investigate the scope and generality of ketene formation from cannabinoid acetates, we studied ∆ 8 -THC-OAc and CBD-(OAc)2 under the same dabbing conditions used for CBN-OAc. The NMR spectra (Supporting Information) of the condensates collected in the impinger from ∆ 8 -THC-OAc and CBD-(OAc)2 display the characteristic doublet at 4.43 ppm for the benzylacetamide methylene, showing that ketene formation is general to dabbing the cannabinoid acetates under the conditions reported herein. The relative levels of ketene produced by ∆ 8 -THC-OAc, CBD-(OAc)2 and CBN-OAc were 1.0 : 13 : 3.6, respectively. To determine if ketene can form upon vape pen usage as well as under dabbing conditions, we vaped a commercial formulation containing ∆ 8 -THC-OAc in a pre-filled, as-received vape pen cartridge. Evidence for ketene formation was also observed in the cartridge vape pen experiments, as shown in Figure .