As a next step, we applied the methods previously tested to a broad range of proteins, which we assembled by considering test cases studied previously with quantum-chemical fragmentation methods as well as a search of the protein data bank for suitable proteins with a size that is still amenable to a supermolecular DFT calculation. In agreement with our results for smaller polypeptides, the eb-MFCC scheme leads to unacceptably large errors. For 1AA3 and 1CTF, the error amounts to 42 and 18 kJ/mol per amino acid, while for 3I40, 1UBQ, 1A1W, 1FKF, 1A1X, and 4PA1 we find errors between 5 and 14 kJ/mol per amino acid. For 3SEM, the error is close to zero, which must be due to fortunate error cancelation in this specific case. As already observed previously , the inclusion of two-body contributions in the eb-MFCC-MBE(2) scheme is able to reduce the error significantly, and we find errors between 1.0 and 4.7 kJ/mol per amino acid, with the exception of 3SEM, for which the error remains close to zero.