Polarization is a phenomenon where atoms and molecules induce changes in the electron distributions of other atoms and molecules they interact with . This effect grows stronger the stronger the electrostatic interactions and/or the more polarizable the atoms involved. Because of their strong electrostatics, then, the electrostatic interactions of charged groups can be particularly affected by polarization. Additionally, anions such as iodide and bromide are highly polarizable, including anions with phosphate or sulfate moieties which are present in a wide range of biomolecules . Phosphates and sulfates play important roles in biological functions, interactions, and are present in drug-like molecules . On the other hand, small cations have low polarizability but can still strongly polarize their environment when it is polarizable.