Knowing allostery can give critical new perspectives for the progress of allosteric drug discovery and development ( ). Among the essential roles allostery plays in many biological processes are those of enzyme catalysis, signal transmission, and gene regulation. Allostery is the phenomenon wherein activity occurs at a distance when a disruption at one point inside a macromolecule causes functional changes at another. Several processes can lead to the modulation of protein activity by allosteric mechanisms: effectorbinding interactions involving small molecules, liquids, DNA/RNA, or proteins; covalent modifications including phosphorylation; and photoabsorption ( ).