Our protocol worked better than standard AutoDock Vina and DOCK 6 docking software Each docking software is associated with a unique docking algorithm and scoring function. Since we are visually selecting the final pose, the scoring function is not that important in our protocol. However, the search algorithm is of crucial importance. If the docking algorithm is not able to generate poses close to the correct binding pose (and score these well enough that they are retained by the algorithm), then there is no good pose to choose from and, the selected final pose(s) will have high RMSD.