Wang et al., investigated the impact of ligandoriginated isomerism and ligand functionalization on gas adsorption of NbO type MOFs. Using two methoxy-functionalized diisophthalate linkers, differing in the orientation of the central part of the linker and consequently, the position of the methoxy groups, they characterise two isoreticular MOFs ZJNU-58 and ZJNU-59, which show different gas uptake and selectivity performance. The orientation of the linker in ZJNU-59 creates a narrower pore size which increases the van der Waals potential overlap thus strengthening the interaction between gas molecules and the framework.