On the Drug Repurposing Hub both fingerprints achieve lower median Jaccard-Tanimoto similarities, especially PH3. This might be due to the smaller dataset size and higher scaffold diversity compared to COCONUT (62% instead of 24%), which generally lowers all median Jaccard-Tanimoto similarities for all fingerprints. Another factor could be a larger range of pharmacophoric arrangements between the drugs considered for the analysis, consistently with the broad range of therapeutic targets of the molecules of this library. In that case, this pattern would affect PH3 more since it considers triplets instead of pairs, which leads to a higher number of potential combinations.