In turn, data from new identified compounds will participate to the completion of existing databases, thereby improving our understanding of the diversity of specialized metabolites biosynthetic pathways. This knowledge will contribute to optimizing the production of high added value compounds in the pharmaceutical industry, as seen in the case of artemisinin production in Artemisia annua through the up-regulation of amorphadiene synthase (multiplying yield by 2.3). Finally, the past and present habits in natural product chemistry research and publishing have led to issues, such as poorly defined chemical composition of plants. Insufficient description and standardization in the natural product practices, coupled with the irresponsible and inefficient management of experimental reference data, can render further research unreliable due to inherent inconsistencies in the substance reporting. This has contributed to the relative neglect of pharmacological studies on natural substances. Additionally, it is essential to enhance the user-friendliness of tools to encourage phytochemists to persevere with better practices.