Within a fixed-charge model, if charges are derived from quantum chemical approaches, as they have been in many present day fixed-charge classical force fields, it is reasonable that the resulting charges should have some dependence on the choice of conformer used for charging. Specifically, both the HF/6-31G* RESP charge model and the AM1-BCC semi-empirical framework which is trained to be somewhat like it, quite reasonably result in conformer-dependent charges. Shouldn't the charges used for downstream modeling (such as that done here) thus exhibit significant conformer-dependence? In other words, quantum chemistry is conformer-dependent.