To be able to evaluate how much of GDB-13 can be reliably sampled from a model, it must be sampled at least 21 billion times. This has an unfeasible computational cost. For this reason, samples of 2 billion molecules were performed, which account for approximately 10% of the optimal sample size. After each sample, several tests were done: the database was checked for duplicates, for invalid SMILES, for non-canonical SMILES and was intersected with GDB-13, yielding 2 subsets: IN and OUT of GDB-13.