Because the tendency of binding-scores to decrease with increasing molecular size and hydrophobicity, the LELP ligand efficiency was calculated from the predicted ∆G values to normalize the docking-scores with respect to the number of non-hydrogen atoms (molecular weight) and logP lipophilicity (hydrophobicity) The graphic comparison between LELP values of children versus their DW docking-score rankings predicted ligands below the average LELP of the parent PC190723 (the closest to 0, the higher efficiency). Those children ligands maintaining their DW docking-scores below < 30 nM and LELP below 3.5 were selected as leads for further analysis (Figure , gray rectangle).