When exciting the SWCNTs at the E22 transition, they exhibit a large Stokes shift of about 400 nm. Therefore, the end of the abscissa corresponds to an excitation wavelength of 200 nm. In contrast, ICG and FITC have Stokes shifts of only 25 nm, which results in higher excitation background signals/cross-talk and shows an influence of the autofluorescence over the full Vis range (Figure ). The actual emission of FITC (~515 nm), is therefore highly influenced by autofluorescence noise, resulting in a SNR in the range of 10 dB. Conversely, ICG exhibits an emission peak in the NIR at 880 nm, which yields a higher SNR of 20 dB. Although SWCNTs possess a relatively low quantum yield of 1 %, 42 the simulation indicates an overall higher SNR of 56.7 dB. This enhanced performance can be attributed to the larger Stokes shift of SWCNTs, which allows filters to more effectively suppress the interfering excitation light.