The S-TVSA process shows a different ranking of parameter importance. For this process configuration, the superheating level of the steam and steam purge flow rate are the key process variables to optimise. The most important adsorbent parameter overall is the H2O-CO2 co-adsorption parameter. However, the CO2 LDF constant is still among the most important adsorbent parameters, alongside the CO2 isotherm affinity parameter, the heat transfer coefficient and, only for productivity, the pellet density, which directly impacts the adsorbent bed density. Meanwhile, the least important adsorbent properties are the heat capacity, the maximum CO2 capacity isotherm parameter, and the CO2 heat of adsorption. These first observations critically show that the design of an optimal adsorbent is very much process-dependent and goes well beyond finding the adsorbent with the highest equilibrium uptake.