Compounds 10a,b,d. To a stirred solution of compound 9 (367 mg, 1.00 mmol) in toluene (10 mL) amine (1.50 mmol) and Na2CO3 (228 mg, 2.15 mmol) were subsequently added. The resulting mixture was heated to 80 °C in an oil bath, stirred at the same temperature overnight and concentrated under reduced pressure to dryness. The residue was dissolved in EtOAc (15 mL) and washed with saturated aq NaHCO3 (3  10 mL), 10% aq citric acid (3  10 mL), brine (3  10 mL), dried over Na2SO4, and evaporated under reduced pressure. Crude material was purified with reverse-phase HPLC to give pure product 10.