By systematically mapping the kinetic modulation for all probe-modulator pairs, we generated a matrix of rate modifications (Figure ). This matrix represents an MD-derived estimate of β-matrix of mutually-catalytic interactions in the GARD model (see Methods). The results clearly demonstrate that the most affected lipid probes are SDS and DDA, having their exit rates diminished by all lipid modulators with varying powers and linearity scores, while other lipids experience very mild catalysis. Notably, the highest kinetic influences in the matrix occur mutually between SDS and DDA, reflecting the cooperativity observed in their accretion profiles (Figures and).