This synthetic approach formed the basis for what is now known as the "emulsionsolvent evaporation technique." Since then, this technique has undergone numerous modifications, the most important of which involves surfactants. In this process, these amphipathic molecules play a unique role in reducing the surface tension between organic and aqueous phases, thereby mixing two otherwise immiscible phases. However, scientists wondered if phospholipids could play the same role. Interestingly, not only did phospholipids appear to function analogously to surfactants in this process, but the encapsulated polymer particles were also surrounded by a phospholipid layer, creating CSHNs. Over time, the repertoire of phospholipids was expanded to include those with cationic, anionic, and