Hence, the inclusion of isobutane in the water lattice does not result in lattice defects (similar to the case of cyclopentane discussed in Figure ), but in the meantime creates spatial obstacles that impede the inter-cage hoping of CO 2 molecules. This theoretical rationale is supported by the NMR results which showed the reduced dynamics of CO 2 molecules in the mixed CO 2 /isobutane hydrate. Interestingly, Moon et al. recently found that proton irradiations could be used to create additional lattice defects in the THF hydrate structure for enhancing the hydrogen encapsulation in the mixed H 2 /THF hydrate. This experimental finding by Moon et al. provides another piece of solid evidence for the defect-enabled acceleration of gas enclathration in the water lattice.