Next, the reaction was run under an inert atmosphere of argon (entry 6). All glassware and reagents were also rigorously dried. Little difference in the reaction outcome was observed when run in either open air or argon. This was an important and surprising finding indicating that the electrochemical polymerization does not require an inert atmosphere, which simplifies the process. In contrast, anionic polymerization of the trisulfide monomers is highly sensitive to moisture and oxygen, and requires tedious preparation of initiators. Notably, our attempted nucleophile-initiated anionic polymerization of the trisulfide monomers was unsuccessful and repeatedly resulted in recovered monomer (S21).