Some reports indicated that silver nanoparticles exert their antifungal activity through disruption of the cellular envelope, causing plasma membrane damage with subsequent cell leakage. Moreover, it is noteworthy that C. albicans, but not C. parapsilosis, C. tropicalis or C. glabrata was shown to be able to convert Ag(I) ions into less toxic silver nanoparticles, thereby evading the antifungal effect of silver. Further studies into more derivatives seem warranted due to the high levels of activity observed in Ag1 and Ag2.