Notably, 3Dmol.js can also be programmatically utilized in Python through an IPython interface called py3Dmol within Jupyter notebooks. Command line interfaces (CLIs) enable users to interact with programs via the command line, although some of these programs may also feature a graphical user interface (GUI). Certain software applications offer multiple interaction methods, such as Blender and PyMOL. Blender and PyMOL are desktop applications that provide both a command line interface and a Python application programming interface (API). Regarding their underlying technology, Jmol relies on a specialized Java-based graphics engine, while 3Dmol.js is a JavaScript library that utilizes WebGL, a JavaScript implementation of the versatile graphics library known as OpenGL , for rendering graphics. Blender and PyMOL have their cores developed in C and also employ OpenGL for rendering.