One journal that has pioneered a first approximation to DARCP flow into PubChem is the British Journal of Pharmacology (although the links are technically indirect) . The annotation task was initially done by editors but since 2016 authors have been incorporating GtoPdb ligand and target identifiers in their text that became clickable out-links in the published HTML and PDF versions. This has the additional advantage of setting up a virtuous circle of reciprocal connectivity with PubMed where DARCP curated by GtoPdb has been submitted to PubChem. This is outlined in Figure .