Many studies demonstrated the ability of cells to adapt their cytoskeleton and, if needed, the nucleus morphology as a response to the surface microtopographies . This ability is often exploited to align and guide the growth of nerve and muscle cells through substrate microstructures like wells or grooves. For instance, Peng et al. proposed a micro/nanostructured PLGA conduit for nerve regeneration, which enhanced the migration rate and the cell guidance ability of immortalized neuron progenitors compared to flat PLGA membranes. Similar to microfibers or grooves, microchannels represent also a major category of microstructures and their geometry affects cellular behavior, as demonstrated by Esch et al. . Esch and colleagues grew HUVECs on square and semi-circular microfluidic channels in static conditions and under flow, finding that the expression of VE-cadherin that regulates cell-cell interactions were similar in the two geometries. However, vinculin, responsible for focal adhesions, was less present in square channels than in semicircular ones, suggesting that the latter promotes better cellsurface communication.