This raises a natural question of how sorghum itself is able to avoid being poisoned by sorgoleone, as sorgoleone is so permeable across lipid bilayers. In part, the high barrier to desorb from a lipid bilayer may contribute. An intracellular concentration of sorgoleone within a root hair cell of 1 nM would correspond to a 1-10 M concentration in the membrane, based on the logP value of around 10 and the concentration definition from Eq. 5. This 1 nM concentration is well below the inhibitory concentration for sorgoleone in vitro. Thus, the intracellular concentration would be smaller, and so long as sorgoleone production is isolated to the root hairs, the flux to other tissues would be limited by the number of membranes that would need to be traversed and the capacity for these other membranes to soak up large quantities of sorgoleone.