Silicon oxide microchips (SOµC) can be produced by employing photolithographic processes providing great platforms for digging into the complicated nature of cellular processes. In contrast to chemically fabricated microparticles, it has been demonstrated that by the utilization of microelectronic-based approaches, micrometric-sized particles of various materials, shapes, and sizes achieve lower polydispersity in the aqueous media . They can provide new insights into both individual cell activities and their population dynamics. Moreover, the biocompatibility of these types of microchips allows them to integrate effortlessly into biological environments without causing adverse interactions. Their uniformity, easy identification, and long-term existence within cells make them invaluable tools for studying intricate biological systems and achieving long-term results. Furthermore, their versatility appears through, as they may be customized with specialized functionalities to meet a variety of research objectives. It has been also shown that they are able to interact with living cells , applying for the cells tracking the micrometric tags , and employing the functionalized microchips as the intracellular pH sensor . Cuboids silicon oxide microchips (3×3×0.5 µm 3 ), among other microchips types, offer a straightforward platform for immobilizing biomedical compounds because the observation of these microchips is easy even under bright-field microscopy . Additionally, as previously described, the cell internalization of these microchips is relatively harmless, and they are able to stay inside of cells for extended periods which facilitates the long-term tracking potentiality. Based on our research experience, the physicochemical properties of compounds can be maintained after conjugation with these types of microchips .