With the focus on advancing the understanding of chiral amine 11 to mediate the lithiation and 1,2-addition reactions, the impact of this component on the cost of the reaction was considered, and determined that it would be a significant cost-driver at stoichiometric levels. Therefore, a decrease in the molar equivalents of 11 was investigated (from the initial 1.5 equiv), and pyrrolidine was examined as co-base to offset the lower amount of 11 (Scheme 5). In this case, the sum of equivalents for both amines was fixed at 1.5 equiv as the amount of 11 was sequentially lowered. Higher yields of the syn + anti-diastereomers mixture were observed when the amount of lithium pyrrolidide was increased from 0 to 1.3 equiv (53 to 75 %, respectively). Nevertheless, a substantial deterioration of enantioselectivity was observed when the amount of chiral base 11 was reduced from 1.5 to 0.2 equiv. These experiments unfortunately concluded that the use of catalytic amounts of the expensive chiral transfer reagent 11 would not be feasible. Indeed, the previously cited literature on the use of chiral lithium alkoxides during the BA reaction also described the employment of excess of the chiral component (1.1 to 2 equiv) relative to quinoline 1, which corroborates our observation and led us to next investigate the impact of other process parameters on the reaction outcome. Scheme 5. Decrease of the equivalents amount of chiral base 11 while increasing lithium pyrrolidide