The mean wall times for complete self-consistent field (SCF) calculations of the PNP systems using models A-D are given in Table . For models A and B, a cutoff radius of 14 Å was Comparing models C and D, i.e., using the entire simulation box without and with MIC, respectively, it is clear that using the MIC results in a minor overhead. The slightly increased cost comes from the additional operations needed to calculate the distance between minimum images (eq 7). Therefore, considering the gain in accuracy, the most cost-effective option is to use the MIC. Compared to the cutoff models, it is clear that model A is by far the cheapest. For the systems investigated here, model A is about 2.5-3.0 times faster than model C, whereas model B is only 1.2-1.4 times faster. However, the reduced computational cost is not for free as it may result in inaccuracies, in particular for model A, as detailed above.