Another surprising observation was that, while overlap with historical compounds is reassuringly low, Table indicates there are still nine of these undesirables in Probe Miner, four in the MLP, and two in the high-quality SGC Probes. The first of these, Bromosporine (UYBRROMMFMPJAN-UHFFFAOYSA-N), was designed to be a pan-bromodomain inhibitor and could be usefully family-selective. The second, GSK-J1 44 (AVZCPICCWKMZDT-UHFFFAOYSA-N), an inhibitor of the KDM protein family is not cell-permeable. The SGC Probes resource has noted this and consequently now recommends a pro-drug of GSK-J1, GSK-J4 (WBKCKEHGXNWYMO-UHFFFAOYSA-N) for cell-based assays.