From the total number of compounds contained in Nat-UV DB (227 compounds), 112 scaffolds were identified, of which 52 (52/112; 46%) are unique. Namely, Nat-UV DB contains scaffolds (52) that have not been reported previously in other Latin American datasets, and that are not present in the scaffolds collection of approved drugs (Figure ). The most representative unique scaffolds of Nat-UV DB are shown in Figure -B, highlighting the presence of derivatives of limonoids, butyrolactones, flavones, pentacyclic triterpenes, etc. The full list of unique scaffolds is available in the Supplementary material. There are previous reports of two Mexican natural products databases (Table ), but the BIOFACQUIM database is the unique one associated with collected geographical data. Interestingly, 74 compounds contained in this dataset were collected in the state of Veracruz (Mexico). This explains that 32 (32/112; 28%) scaffolds are shared in both databases (Figure ). Also, 17 (17/112; 15%) scaffolds are shared between Nat-UV DB and UNIIQUIM, while 53 (53/112; 47%) scaffolds are shared between Nat-UV DB and the LaNaPDB. Finally, 24 (24/112; 21%) scaffolds were shared between Nat-UV DB and the approved drugs collection. In other words, Nat-UV DB contains some natural product scaffolds (60/112; 54%) that have been identified previously in Mexico and other Latin American countries or have been used as a drug.