Controlling nucleation and growth processes and understanding the mechanisms involved, is one of the most challenging tasks for advanced materials synthesis, and it has been tackled from different perspectives and for different cases, such as sol-gel-based materials, zeolites, and later extended to MOF materials. For Classical Nucleation Theory (CNT), the initial process towards the formation of a crystal is nucleation (the reader is referred to the numerous reports specifically discussing nucleation and growth theories and the short summary provided in the SI file). Nucleation is highly influenced by synthetic conditions and is typically addressed in terms of the supersaturation of the system. Supersaturation is ultimately related to the chemical work ∆µ resulting from molecular transportbased phenomena taking place, which can be written as ∆µ = k B T ln (C/C 0 ), where k B is the Boltzmann constant, T is the absolute temperature, and C and C 0 are the concentration of supersaturated and saturated solutions respectively. Due to such a strong influence of temperature and concentration on the above-discussed processes, and to be able to establish a straightforward comparison between experimental data, solvothermal synthesis (i.e., experiments carried in hermetic vessels, at temperatures higher than the solvent boiling temperature) will not be included in the present analysis. In addition, the data was filtered under the condition of times longer than 10 minutes to guarantee a homogenization in the mixing and completion of the first nucleation stages, such as Crystalline Primary Particle formation (vide infra). Synthesis procedures including chemical modulators (i.e., species affecting the availability or coordination environment of at least one of the MOF constituents and influencing the nucleation and growth process) have also been widely used to alter the ZIF-8 synthesis; since they affect the underlying mechanisms of ZIF-8 formation in fundamentally different ways (and therefore not easy to capture through a ML approach), reports in which chemical modulators were used will not be included in our analysis.