Again, we first run 100 meta-MD simulations for each of the 20 reactant pairs with the primary parameter set (k push =0.05, α = 0.3, s = 0.8), which results in a total of 588 elementary reactions (average of 29.4 per reactant). Among these reactions are 16 of the 20 target reactions but R129, R2191, R10077 and R7854 (Table ) are not found. The lower success rate compared to unimolecular reactions (16/20 vs 23/26 for this parameter set) is likely due to the increased number of reactions per reactants (29.4 vs 17.3 reactions per reactant on average). For a reactant system with only a single viable path (low-barrier single-step product) we expect a high probability that at least one of the 100 meta-MD simulations will go to that product. However, for a reactant system with, say, 29 low-barrier single-step reactions there is a good chance that at least one of the 29 reactions will not be found by meta-MD in any of the 100 simulations. Assuming all 29 reactions are found with equal likelihood there is only a 40% chance that 100 meta-MD runs will find all 29 reactions, compared to a 96% chance for 17 low-barrier reactions.