(2) If the central angle is orthogonal or parallel to all other angles, an order parameter value of -1 or +1 is obtained. If the distribution of angles is completely random, such a parameter becomes 0. We adapted the algorithm by weighing the average by the amplitude of the angles, calculated as the amplitude of peaks in Fig. over baseline. We weigh first by the amplitude of all surrounding angles (θj) and then by the amplitude of the selected central angle(s) (θi) (Eq. 3) WOP = 2 * 𝑐𝑜𝑠 2 (𝜃 𝑖 -𝜃 𝑗 ) -1.