Then, the new scheme for the construction of orbital maps will be explained (Sec. 2.2) and changes in the multi-level prescreening procedure compared to previous work will be described (Sec. 2.3). In order to find suitable prescreening parameters, the influence of different pair selection thresholds will be examined in Sec. 3.2 for organometallic reactions. The performance of the resulting pair-selected multi-level DLPNO-CCSD(T 0 ) method for the calculation of reaction energies and barrier heights will be mainly demonstrated in Sec. 3.2 for organometallic reactions and in Sec. 3.4 for various organic reactions. Within the latter section, the influence of core orbitals as well as the basis set will be further analyzed and the behavior of the error with respect to canonical CCSD(T) will be discussed for a smaller test set of proton transfer reactions. In addition to that, the applicability for studying full potential energy surfaces and large weakly interacting systems will be investigated in Sec. 3.3 and in Sec. 3.5, respectively.