Ngai et. al. extended their tandem acyl radical addition-cyclization strategy to synthesize a useful "tetralin" scaffold, crucial in various bioactive and pharmaceutical compounds, using CuI and rac-BINAP as catalyst and ligand, respectively (Figure ). Substrate electronic and steric properties exhibited negligible influence on reactivity with product yields ranging from 40% to 89% (Figure ). In 2022, Ngai and co-workers also demonstrated a [4 + 1] annulation reaction utilizing the versatile photocatalytic activity of in situ generated Cu(I)-BINAP catalysts, presenting a streamlined approach for synthesizing α,β-unsaturated-γ-lactams; 118 a structural motif prevalent in natural products (e.g., ascosali pyrrolidinone A) and pharmaceutical compounds (e.g., imrecoxib). Leveraging the nucleophilicity of acyl radicals, the authors demonstrated their addition on acrylamides in the presence or absence of alcohol or water additives furnish a diverse array of -alkoxyl, -hydroxy, and -hydrogen α,β-unsaturated--lactams (Figure ). Moreover, the authors extended the utility of the α,β-unsaturated-γ-lactams towards synthesizing useful molecular scaffolds, by carrying out a series of product post-functionalization reactions (Figure ).