or with slow dissolution and/or membrane diffusion rates are likely to exhibit drug interactions brought on by P-gp inhibition in the gut that are clinically significant. There are exceptions for some drugs that are taken at high doses (over 50 mg), however, these drugs are either big (>800 Da) or produced in formulations that take a long time to dissolve. Cyclosporine, paclitaxel, and saquinavir hard-gel capsules are a few examples of such drugs .