Glycans are highly abundant biomolecules found in all living organisms. They form dense layers on cell membranes, proteins, and other biomolecules, facilitating a wide range of biochemical reactions . The glycosylation processes are highly sensitive to various factors, such as environmental conditions, cell activities, nutrition, cell growth cycles, cell health, etc . To investigate glycan-mediated cellular processes, frequent monitoring of glycan changes in biological samples is essential. However, glycan analysis poses significant challenges due to their intricate structures, including complex isomeric forms, glycosidic linkages, and branched structures.