Our work ow is based on merging customer requests with plate layouts to arrive at a nal plate design. SMILES 9 strings of reactants and products are exported from our ELN 10 as an Excel le and imported into our Google Sheet application (Figure ). In there, other data points such as Inchi Key, molecular weight and formula are automatically generated using a FASTAPI wrapper for RDKit 12 and isospec++ 13 . After specifying additional metadata such as customer guidance and type of (side-) reaction, the request is processed and a Google Slides presentation generated. As a next step, users can build and design screening plates (Figure ). They can choose up to three substance categories to be placed in rows or columns and start either from a blank design or a standard plate. For each substance category, individual compounds can be selected as well as the number of variations of the same compound. The latter can be used to compare the performance of different batches, molar equivalents or ways of dosing. The system provides all permutations in rows and columns for the user to include in the plate design. There is also the possibility to screen more than twelve members of a substance category and the tool will alert users if there are no dosing heads or bottles of any selected substance available in the gloveboxes or on the solid dosing robot. In a third sheet called FileGenerator, we combine the plate with a reaction and choose for each component how it should be dosed and how much (Figure ). While the eld is automatically pre-lled based on the presence of density information, the operator can also choose from solutions registered for this compound. The sheet also provides a choice of different batches and indicates for each batch whether it's available for dosing. It will automatically ag intended amounts, if the total weight needed to run the plate exceeds what is available in the glovebox. Finally, the user has to de ne reaction temperature, time, goal and procedure before saving the plate. During that process, all data is saved to different data tables, the corresponding presentation updated and the les needed for solid-dosing, liquid-handling, LC(MS) and plate setup are written to Google Drive.