• CD8 | Colon cancer CD8+ T cells play a crucial role in the immune response against colon cancer, particularly in the context of immuno-oncology. These cells are pivotal for anti-tumor immunity, and their presence and activity within the tumor microenvironment (TME) are associated with better clinical outcomes. CD8+ T cells can directly kill cancer cells through the release of perforin and granzymes, which induce apoptosis in target cells. They produce cytokines such as IFN-γ and TNF-α, which have anti-tumor effects and can enhance the function of other immune cells.