To investigate the influence of the excitation intensity on the SNR, we varied this parameter from 0.1 µW/cm² to 1 W/cm², creating a 2D contour plot. We specifically analyzed the conditions under which the SNR exceeds 20 dB, which indicates a signal 100 times stronger than the background noise (Figure ). For the Si detector, this threshold is reached at an excitation intensity of 0.1 mW/cm² for wavelengths ranging from 700 to 1050 nm. In contrast, InGaAs detectors require intensities above 10 mW/cm² to achieve the same SNR value. Although the optimal excitation intensity range for Si-photodiodes is relatively narrow, they appear to achieve a higher SNR overall, even at lower excitation intensities. Notably, the emission range of (6,5)-SWCNTs falls well within this optimal range, further enhancing their utility in biosensing applications. An approach to further increase the SNR in the context of in-vivo applications is to modulate the excitation wavelength, which filters the fluorophore emission. 43