Moreover, the CMMC model could be applied to screen a wide range of synthesis conditions to identify unconventional initial reactant loadings, delivering a MMA-rich polymer with similar thermal properties and with a sufficiently high Mn as well as a sufficiently low Mn after degradation by hydrolysis, mimicking natural disposal. Notably the designed drop in Mn (up to 25 times) is sufficiently high to create MMA segments that can be seen as oligomers, as experimentally confirmed.