There are now approved RNA medicines for cardiovascular, metabolic, liver, infectious, neurological, and neuromuscular, kidney, and eye diseases with many more in the research phase. Although there are many types of therapeutic RNAs, ASOs dominate the approved drugs followed by siRNAs. CRISPR and AOC therapeutics currently have high research interests still in preclinical stage. The top RNA medicine companies such as Moderna, Ionis, BioNTech, Alnylam, and Sirnaomics all specialize in one type of RNA but research and treat as many as nine different diseases. RNA therapeutics have the potential to treat a wide range of diseases from the most common to the extremely rare.