The selective oxidation reaction performed with mixed-metaloxide heterogeneous catalysts enables the transformation of abundant light-alkanes (e.g., ethane, propane and n-butane) into the valuable products olefins and oxygenates. However, the initial alkane might undergo multiple reactions on the surface of the catalyst in the presence of oxygen molecules (O2), Here, the values in parenthesis are the standard reaction enthalpies. Selectively forming the desired products, and, in particular the value-added oxygenate, is therefore a challenge.