No key substructures which induce either lysosomotropism or non-lysosomotropism were found here. In the MMPA, we do not identify any dominant chemical substructures which determine lysosomotropism in our data. Similarly, while examining the Fingerprint model with X-FP, the important bits usually encode sp3 -hybridized carbon substructures and basic nitrogen substructures. We hypothesise that these substructures influence lysosomotropism by a↵ecting the overall physicochemical properties of the compounds instead of causing specific chemical structurebased activity.