A group of scientists from the public and private sector intend to launch a benchmarking initiative to accelerate the development of computational methods to predict small molecules that bind to proteins. The initiative will comprise an experimental and data hub(s), which will support a community of predictors. All data, including chemical structures, will be made available without restriction on use. The initiative intends to attract funding from industry, governments, and foundations to support the infrastructure, and challenge-specific funding, in order to give diseasefocused funders the opportunity to target the community-wide effort to proteins of interest to them. An organizational meeting is being arranged, with the intention to launch the first CACHE challenge in early 2022.