Alterations in the Purine metabolism pathway may contribute to cancer development and progression by influencing key cellular processes. For example, dysregulation of enzymes involved in this pathway, such as adenosine deaminase (ADA) and purine nucleoside phosphorylase (PNP), has been shown to promote tumor growth and metastasis in certain types of cancer. These enzymes are involved in the degradation of purine compounds, and their dysregulation can lead to accumulation of purine metabolites, which can potentially disrupt cellular processes and promote cancer cell survival and proliferation. Moreover, the Purine metabolism pathway has been implicated in the regulation of immune response and inflammation, which can play a critical role in cancer development. Purine metabolites, such as adenosine, can modulate immune response by acting as signaling molecules that regulate immune cell function and inflammation. Dysregulation of Purine metabolism can disrupt the balance of purine metabolites, leading to altered immune response and inflammation, which can promote cancer cell survival and facilitate tumor growth.