In order to devise a way to get rapid access to a large number of structurally different PNPs, we analyzed the full library of 3.5 million synthetic small molecules and screening libraries, which are available and widely sourced by the scientific community from Enamine 17,18 for PNP content (Enamine-PNPs), as a proxy for potential future bioactive compounds. We assessed the spatial complexity of the Enamine library using the recently developed normalized Spatial Score (nSPS), and evaluated the bioactivity of a selected subset of PNPs obtained from Enamine in the unbiased morphological cell painting assay (CPA). The analysis revealed that 32% of the Enamine library are PNPs. Their predominant fragment composition and combinations resemble those of PNPs identified in the recently released ChEMBL 32 dataset.