The system then heals the SV via the return of the Graphene atom displaced in step I-II to the original position, bonded to C u1 and C u2 and carrying the functional metoxy group with it. This leads to the formation of trans func-Figure . Mechanism a for the trans-functionalization at the BLG-methanol interface at 6.8 GPa observed in SPRINT metadynamics simulations. On the top, snapshots associated with the main steps of the reaction mechanism (the color code is the same as in Fig. ).