Naproxen-PEG ester conjugates were successfully synthesized via Steglich Esteri cation. As logP is a metric suitable for examining the ability of a drug to permeate the cell membrane and perform its function, it is important that pharmaceuticals have a logP within the therapeutic range. It has been determined that the optimal logP value ranges from 0-310. Therefore, the conjugation of PEG to naproxen was successfully performed to lower the logP of naproxen to promote therapeutic e cacy. Naproxen-PEG conjugates exemplify increased release behaviors in acidic and neutral aqueous environments and chromatographic examination shows an increase in polarity and decrease in logP.