Through further iterations, the categorical variables were exploited: DMSO and DPEPhos, with the most forcing continuous parameters: 60 minutes residence time with 10 mol% catalyst loading at 150 °C. These were determined to be the optimal conditions as found by the self-optimization workflow, giving the product in 82 % yield in 10 experiments using only 450 mg of the starting material, 23. Despite this functional change, the algorithm was still able to determine the optimal conditions utilizing previous data and quickly found that although a similar reaction task was present, further exploration of the parameter space was necessary. This further shows the adaptability of the MTBO approach to wider substrate scopes with different functionalities. This experimental data is displayed at the end of this section in Figure (green dashed line).