This study aimed to discuss the overall state of research based on NPs from plants in Colombia's coffee region. To this end, we performed a bibliometric analysis to summarize the advances in this field documented in English in the last years in two databases Web of Science (WoS) and Scopus. This article summarizes and analyzes the results of the number of annual publications, geographical distributions, publishing journals, publication affiliations, citations, keywords, and critical research points in this realm.