Biomarkers detection have become an essential tool in medical research and practice, aiding in the diagnosis of diseases, monitoring treatment effectiveness, and identifying potential drug targets. However, modern-day medical diagnostics still faces significant challenges, such as limited sensitivity and specificity, high cost, technical complexity, low sampling-to-detection cycle turnover and more, which can impede their efficacy and practicality in patient care . Despite the remarkable advances in medical diagnostics, there is an ongoing enormous need to address these challenges, in order to enhance their applicability in the medical industry. Biomarkers, as quantifiable indicators of biological processes, hold significant potential in providing essential information on the health status of patients.