Following the principles of microfluidic hydrodynamic focusing, we have developed a platform for the synthesis of liquid crystalline particles. Cubosomes (both Pn3m and Im3m) and hexosomes (p6mm) were produced on-chip with exemplary size control, ranging between 180 nm and 300 nm. This has profound implications for the field of soft-matter nanotechnology; size being a critical parameter in determining particle end-function. The process benefits from unique advantages associated with microfluidic technologies, including low energy consumption, minimal user input, and integration of downstream processing modules. The scalability of MHF for has previously been demonstrated via parallel assembly lines and aspect ratio changes in channel architecture, which will no doubt apply to this method should industry-scale synthesis be required. Samples were generated at rates of over 400 µl/min at 1.4 mM Crucially also, particles were stable at 37 °C and were comparable in crystallinity to those of a similar composition generated via probe sonication, without the need for elevated temperatures and high-shear conditions known to destabilise more sensitive biomolecular cargo.