The capacity for these new reactions to dramatically simplify the way quaternary-center containing molecules has been exemplified through 11 different case studies (see SI for complete listing), of which six examples are illustrated in Figure . Thematically what all of these examples have in common is a near exclusive reliance on polar bond analysis during the planning stages, especially carbonyl chemistry. As a consequence, the conventional routes to these mostly simple structures rely on extensive redox manipulations, function group interconversions, and a variety of pyrophoric reagents for various carbonyl reductions. In contrast, direct carbon quaternarization sidesteps these inefficient tactics through a modular LEGO-like transformations of commercially available building blocks (olefins and acids).