There is significant research still ongoing in identifying novel biomarkers and mutations involved in the onset of AD and PD. Developing disease models is critical in understanding disease biology and pathology, and CRISPR has shown promising utility in the same. Few of the examples are -cellular model of AD with disease-causing mutations in APP and PSEN1; 275 mouse model for AD with tau knock-out 276 and a monkey model for PD with PINK1 deletion. 277