In this paper, an amino-acid-based, next-generation organic nanozyme (OA nanozyme) is proposed, which possesses peroxidase-like catalytic activity. The modified organic-compoundbased nanozyme fabrication strategies, via single-chelation/polymer entanglement, have successfully generated small nanoparticles (mostly within 100nm of physical diameter) with partially mimicked cofactor mimetics (e.g., Fe-N sites), and morphological homogeneity. The OA nanozyme possesses decent substrate affinity (e.g., Km = 0.009 mM, H2O2), and compatible biocompatibility, validated by high cell viability, indicating low biotoxicity and sustainable profiles. OA nanozyme incorporated with the customized colorimetric sensing platform enables the fast (up to three minutes) detection of allergic molecules detection (e.g., histamine), with a decent LOD (21.37 pgmL -1 ) and with selectivity among a mixture of up to seven agrichemical and biomolecules. This OA nanozyme is envisioned to enhance the diversity of organic nanozymes and contribute to an allergic molecule sensing system for further applications in agricultural and food safety.