To navigate through chemical and biological spaces more intuitively, several researchers have developed methods that seek to improve the interpretation by representing molecules beyond individual data points. An example is the scaffold tree approach that graphically represents chemical space as a tree, where the leaves represent individual chemical compounds and the intermediate nodes represent scaffolds and sub-scaffolds . These representations allow a more consistent scaffold analysis in an SAR/SPR context and facilitate the identification of analog collections . To facilitate the visualization of large analog series Constellation plots have been proposed (see section 2.3) .