Originally launched in 2010, OpenMM is a GPU-resident simulation engine that specializes in efficiently running numerical Chapter methods on the GPU using either OpenCL, or more recently CUDA . OpenMM offers a robust C++ API allowing for lowlevel functionality additions as well as a Python API that enables users to rapidly begin generating simulation data. The docs are online and the source code is available on GitHub (). OpenMM is easily accessible via standard Python package managers such as Anaconda via the conda-forge channel.