The examples above demonstrate that chemical switching can be a useful strategy for regulating many different catalytic processes. Chemical switching can also take advantage of solution equilibria to tune reaction rates in a dynamic fashion. In cation tuning, different amounts or types of metal salts could be used to achieve different effects without requiring tedious synthetic modifications of the catalyst. Ideally, the chemical switch is only needed in catalytic amounts relative to the substrate (e.g., in cation switching) or is incorporated into the reaction product (e.g., in CHO and CO2 ROCOP). Some possible disadvantages of chemical switching are that the chemical reagents used are not traceless so they might need to be removed from the final product or they might not be compatible with subsequent steps in one-pot tandem or cascade reactions. Another potential limitation in cation switching is that the catalyst must be amenable to installation of secondary metal binding groups to achieve high cation responsiveness.