A common design principle in catalysis that can affect both reactivity 1 and selectivity is the identity of active species and metal ligation state. Ligands that dynamically change the metal coordination environment, i.e., hemilabile ligands, are often able to address the tradeoff between catalyst activity and stability because they can ligate and protect the transition metal while partially disengaging and making a catalytic site amenable for a reaction. Hemilabile ligands have been used to address major challenges in organic chemistry, such as reactivity selectivity tradeoffs in enantioselective , regioselective , and chemoselective 11 catalysis. While hemilabile ligands have been primarily used in homogeneous catalysis, their unique properties have also been utilized in nanoparticle , single atom , and heterogeneous catalysis in recent years.