Table Parameter estimates that were deemed to be active in effecting the monodispersity of SPION@SiO 2 nanoparticles formed, described as nanoparticle entropy (E n ). The parameter estimates were calculated from the regression analysis and used in the prediction expression. In the case below, the fractionated addition of TEOS is included as a parameter, regardless of its p-value, due to its presence in the interaction term.