Given the long history of herbivory in animals (and associated polyphenolic compound ingestion), and the high prevalence frequency of the β-glucuronidase-coding gene GUSB across vertebrates, this mechanism could be a long-ago evolved broad response under selection pressure of viral pathologies in ancestral species. It would be worthwhile for future investigators to probe the genetic basis for neutrophilic β-glucuronidase expression and its orthology across vertebrate species in order to better localize how this response evolved.