It can be seen that the rejection is solely the artifact of using made up inventory information. If the inventory status in the scenario shown in Figure had come from a real inventory status, then it can be seen that increasing the search depth could not have affected this information for a given substance. Therefore, the status of substance YEWFMQPTEIBRFH-UHFFFAOYSA-N would be starting material in both scenarios. Accordingly, the SynGPS algorithm would determine that the reaction ASPR 1001638987 is unnecessary, as its product is available from inventory and consequently it would have resolved this cycle, and deemed the synthesis route as viable.