Unsurprisingly, little literature exists on the delivery of mRNA with MOFs, possibly due to the fragility of mRNA compared to its shorter counterparts (siRNA and miRNA). Furthermore, no studies have delivered mRNA using MOFs in vivo. mRNA is extremely fragile, readily susceptible to intramolecular catalysis of strand breakage, oxidation, or reactions with impurities such as aldehydes, metals, and peroxides, and degradation by ubiquitous RNases, rendering the mRNA inactive. To our knowledge, the coprecipitation and delivery of mRNA by MOFs remain underexplored, and our work seeks to fill this gap.