The biodegradation profile of the obtained amphiphilic hybrid networks was evaluated by performing hydrolytic and enzyme-catalyzed degradation. In the case of hydrolytic degradation, samples (disk diameter 1.2 cm cut using a manual puncher) were placed in 5 ml simulated body fluid (SBF) that was prepared in the laboratory and the pH was adjusted to 7.43 in a 12-well plate and then kept on a shaker in an incubator at 37 °C. Hydrolytic degradation was carried out for 7 weeks. Poly(ε-caprolactone) (PCL) (Capa 6430) was used as a positive control for hydrolytic and enzymatic degradation studies.