Data was collected at the IMCA-CAT beamline at the APS and processed using autoPROC and STARANISO . Molecular replacement was performed using PHASER of the CCP4 program suite using the AlphaFold 37 model of PfCLK3 kinase domain as a search model. Ligand restraints were generated using Grade2 . Iterative rounds of model building and refinement was performed using Coot 39 and BUSTER .