To rigorously test the model performance, we examined four radical precursors (8, 10-12) as an experimental validation set. As shown in Figure , the experimental yields are in excellent agreement with the predicted yields, demonstrating the validity of our model. Accurate DFT calculations of the full pathway for >100 substrates would be computationally intractable for the time scales necessary for retrosynthetic analysis. With the model reported herein, dozens of substrates can be evaluated in less than a day, whereas full analysis by DFT of a single substrate requires weeks.