This analysis showed that the 1B/3B with SLC gave better results than 1B/3B without SLC, but also compared to MT and AA resolution. For GSN, B1 and GFP, the SLC values that lead to the best results are generally between 0.08 -0.1 with SC of 0.7 nm 2 -0.8 nm 2 . Instead, for the 12mer RNA, a SLC greater than 0.1 with SC between 0.8 nm 2 and 1 nm 2 is more in agreement with the reference. panel: logarithm of the SAXS profile of a representative, randomly selected, GSN frame calculated using 1B mapping (blue), 1B mapping with the best combination of SLC (0.08) and SC (0.6 nm 2 ) found for this frame (orange) and using WAXSiS (black). Bottom panel: residuals of 1B (blue) and 1B with SLC (orange) using the WAXSiS intensity as reference. B) Upper panel: logarithm of the SAXS profile of a representative, randomly selected, 12-mer RNA frame calculated using 3B mapping (blue), 3B mapping with the best combination of SLC (0.120) and SC (1.0 nm 2 ) found for this frame (orange) and using WAXSiS (black). Bottom panel: residuals of 3B (blue) and 3B with SLC (orange) using the WAXSiS intensity as reference. All the SAXS intensities were calculated for 101 𝑞 values, up to 0.3 Å -1 .