In a short note, George Whitesides addresses lucidly the probability of life . He writes that no one yet knows how to bridge the gap between mixtures of compounds to the networks of interconverting molecules that make up living cells. He then claims that origin research should best take a bottom-up approach, i.e. pursuit of prebiotic catalytic networks of simple, easily available molecules. One caveat mentioned is that early networks may be too kinetically unstable to withstand extreme environmental conditions. The recently expounded scenario of spontaneous formation of mixed amphiphile assemblies, e.g. nanoscopic micelles, along with the documented potential for the emergence of self-reproducing mutually catalytic networks within such assemblies , strengthens the validity of the bottom-up approach. Such scientific slant does not necessitate the imperative involvement of extant biological building blocks in life's origin, and allows the exploration of other molecules and assemblies thereof, such that have the best potential to create catalytic networks capable of primal evolution . The compositional persistence conferred by the attractor dynamics portrayed herein may help overrides the network kinetic instability caveat, lending further credence to the catalytic network origin scenario.