Reside contact maps provide another means to compare crystallographic and MD-based interaction networks (Figure )). Here we plot crystallographic contact maps and MD-based ones analyzed using a 10% cutoff. Generally, interactions within α-helices and β-sheets are constant between the two. In contrast, more dynamic regions displayed greater variation in the contacts found and their relative conservation scores, particularly interactions between neighboring 𝛼-helicies or within loops and linker regions. These observations support the notion that the conserved interactions within secondary structural elements can be reliably described with either of the methods, but the analysis of crystallographic structures alone might be insufficient to capture more dynamic interactions.