Various previous studies can further illustrate the good performance: ddCOSMO was used to solvate viral capsides of up to 7 million atoms in less than 1 hour , ddPCM was used to solvate a system of ∼625k atoms in ∼5 hours on a single core , and finally ddLPB was tested against the TABI-PB and the APBS finite difference method LPB solvers, finding that it performs similarly for loose accuracies and that outperforms both when a higher accuracy is requested .