In Figure the hydrophobic core region in the SAXS electron density profile (59 Å) corresponds with the inner peak-to-peak distance in cryo-ET and SPA profiles in Figure and p (66 Å and 63 Å, respectively). Previously the hydrophobic core region for a similar polymer, PBd23-PEO16, was simulated to be 63 Å. Although the PBd23-PEO16 polymer used in the previous study is slightly larger than PBd22-PEO14 used here, there is good agreement between these previous simulations and our experimental peak to peak measurements from cryo-ET and SPA.