Examples of molecules classified as 'inside', 'maybe', and 'outside' were carbamazepine, sudan I, and coronene, respectively. When comparing the relationship between XlogP and r i , it is clearly observable that these parameters, even though relatively linear, are insufficient to determine if a chemical fits the RPLC subspace, figure . In figures S16,S17, and S18, the XlogP values of the chemicals with the same r i range vary between -10 to +10 units.