In this article, we evaluate the relevance of generic CG models for the determination of the NMR relaxation rate R 1 for protons of spin quantum number I = 1/2, for which the primary relaxation mechanism is dipoledipole interaction. To do so, a model polymer system made of short PEG chains in water is used. Two types of simulations are employed, AA and G-CG, and their respective values of R 1 are compared. In addition, in order to differentiate between the effects of using a model with reduced number of degrees of freedom (i.e., a CG model) on the NMR relaxation rate measurement, and the known discrepancies between AA and G-CG models, R 1 was also measured from monomers center-of-mass (CoM) in the AA simulation. The latter yields the same reduced level of detail as the G-CG simulations, but with exactly the same molecular dynamics as the AA. We discuss the differences in R 1 between the AA and the CG/CoM models by splitting the signal into intramonomer, intermonomer, and intermolecule components. Finally, we propose a method to correct the values of R 1 obtained from CG models, allowing us to directly compare R 1 results from CG simulations with results from NMR experiments.