In this work, we also introduced the first library of standard charged and zwitterionic phospholipids to be used with the HhPF method. In fact, our ∂-HyMD is, by design, a flexible tool that can be easily applied to diverse systems. Future work will be focused on the enrichment of this core library with other biologically relevant lipids, including sphingolipids, sterols, and glycosylated systems (phosphorylated inositol phospholipids, lipopolysaccharides). A further step will be in the use of this same approach for the calibration of sequence-specific peptide models, and of nucleic acids, with the final objective of producing a consistent force-field for simulations of complex multiphase biological systems. Changing the mapping and including the optimization of the bonded