To investigate solid solutions with ChemDASH, the methodology has been advanced to allow for variable compositions to be investigated in a single ChemDASH run. Our variable composition version of ChemDASH (vc-ChemDASH) allows for the composition of the structure to be changed at a given ChemDASH step rather than the swapping of atoms already in the structure. The aim of allowing changes in composition is to use information of spinel configurations in similar compositions to efficiently explore both composition and configuration space. In the initial testing presented herein, solid solutions between the ZnFe 2 O 4 and MnFe 2 O 4 spinel structures are explored using this methodology. This phase space is a good initial test of this methodology as these two systems are both known to be most stable in their normal spinel configurations and the two end members are known to be stable and form a solid solution.