Taken together, our results strongly suggest that BO can be used to efficiently explore the peptide sequence landscape with minimal experimental effort (i.e., reduced number of peptides that need to be synthesized and tested), contributing to a more efficient and sustainable drug discovery process. In the future, to make the optimization pipeline fully operational and suitable for real-world applications, additional extensions and other crucial molecular and pharmacological properties, such as solubility, synthesizability, and proteolytic resistance, might need to be considered.