Current research shows that DNA and RNA aptamers have a median K d value of 32.8 nM and 19.7 nM respectively. This novel method of modifying nucleic acids displayed here has been producing aptamers in the range of 1-3 nM, and giving an improvement in affinity of up to 3.3-fold. The experimental validation using the EGFR binding assay has been backed up with computational modelling, which provides a structural basis for the changes in affinity and could be used to further refine the aptamers. A typical SELEX process takes 2-3 months for selection and sequence identification. After the development of the methods described herein, it is possible to synthesise an aptamer library in one week, perform FABS in one day, followed by four weeks of sequence analysis, (for which RoboOligo is invaluable). This novel method could improve the success of aptamer discovery processes and general drug discovery process, making them more cost and time effective. Outside of the aptamer field, this method has the potential to impact drug discovery processes with this new method of synthesising and screening large drug candidate libraries rapidly.