Synthetic chemists seek a better balance between performance and sustainability in chemical processes . Synthetic biologists and systems chemists analyze biotic reaction networks to understand or design new bio-inspired reactive systems . Scientists in these disciplines need a representation of chemical reaction data that explicitly accounts for the connectivity between chemical reactions. Moreover, with the emphasis shifting from individual reactions to reaction sequences, scientists' requirements increase accordingly, creating a pressing demand for route-level analytic based on quantitative descriptors and multi-parameter metrics. In addition to a general data model, they need tools (software, databases, etc.) to manipulate and investigate chemical sequences and networks.