Returning to our discussion on the entropic component of the total synergistic effect, -T ∆ C S DS -,W ⊕C (z), (in the context of Fig. ) we can see the relative contribution of the difference in head group water-desolvation (between the ACWI and the AWI) compared to the difference between transferring the solute cavity from bulk water into the C 12 E 6 monolayer (ACWI) and transferring the cavity from bulk water into the vacuum (AWI). Since -T ∆ el ∆ C S vw⊕el,W ⊕C (z) is net-attractive, we see that the cavity effect overpowers the water-desolvation effect.