However, its stability decreased significantly when transferred to the neutral condition, to below the stability of the neutral polymorph (Figure b, Table ). Arguably, this shift of fibril stability is caused by the higher solubility of αSyn in the neutral pH compared to the acidic one leading to (partial) fibril dissociation upon the pH jump. Similar destabilization of αSyn fibrils upon change in pH was observed by others and could be an important phenomenon occurring in vivo . Discussion: