In terms of optimization steps, 10 Sobol iterations precede 40 Bayesian optimization iterations. All Sobol iterations were required to be completed before moving on to the Bayesian optimization iterations. Alternatively, setting the number of Sobol iterations to the default of twice the number of parameters and/or reducing min_observed_trials (i.e. able to evaluate second step trials before completing first step) may have been appropriate choices which we do not expect to significantly impact the findings in this study.