Fiber meshes are highly tunable and amenable to the development of an alternative to membrane dialysis materials. Protein adsorption at the blood-material interface plays a crucial role in directing the host response to biomaterials. However, the buildup of uremic toxins in the blood of patients with kidney failure complicates the adsorption of proteins, never mind the enzymatic reactions that drive the host response to these surfaces. To this end, PCL-based fiber meshes were exposed to platelet-poor plasma with and without uremic toxins to understand the proteinsurface interactions. It was observed that PCL surfaces adsorbed large amounts of proteins, likely due to the hydrophobicity of the unmodified surfaces. Moreover, the presence of uremic toxins led to a significant increase in adsorbed protein. However, despite more protein adsorbed to the surfaces, this did not translate to increased rates of clot formation, suggesting that adsorbed proteins are likely unable to undergo enzymatic activation. This is further supported by the relatively strong adsorbed fibrinogen bands but relatively weak cleavage response. Finally, the high levels of C3 activation and IgG adsorption indicate that these unmodified PCL surfaces may elicit a strong humoral immune response. This is the first step in understanding how uremic toxins affect protein-surface interactions, which is crucial to the design of personalized medicine approaches for treating patients with kidney failure.