This study discovered that Zika E/TrkA endosomes are carried retrogradely into the cell body. In other words, ZIKA infection results in the transmission of a significant number of TrkA signals to the neuron's cell body. Thus, retrograde transport of Zika E/TrkA may result in aberrant activation of Trk receptor signals, including those of the Ras, Rap-1, and Cdc-42-Rac-Rho families, as well as those of the MAP kinase(72), phosphatidylinositol 3-kinase (PI3K)/Akt, and phospholipase-C-(PLC-) regulated pathways. As a result, ZIKA infection can impair neuronal growth and maintenance of phenotypes.