We begin this section by noting that this technique, shown in Figure , has prevailed over the evaporation of emulsifiers. In this modified technique, which combines the nanoprecipitation technique with the concept of self-assembly, the main aspect is that the active molecules and the polymers are dissolved in a water-miscible solvent such as acetone , ethanol , or acetonitrile . Then, this solution is added to the aqueous solutions of lipids (e.g., PEG -conjugated or -unconjugated phospholipids) with continuous stirring, whereupon the lipid molecules and polymer particles spontaneously self-assemble in the solution (the lipid concentration in the solution should be high enough to surround the polymer core) .