However, the water penetra on was slower for the ASD with 40% drug loading than for the 20% drug loading, with the interface now appearing at approximately -68 µm and -90 µm from the original interface at 1 and 2 min, respec vely (also see Figure , in the Suppor ng Informa on). In addi on, the discrete increase of water content at this interface was slightly lower, at about 8%. At later me points, the glassgel interface had again penetrated into the film beyond the field of view. Overall, compared to the 20% drug loading, the water concentra on in the film is lower and, conversely, the polymer concentra on in the buffer is also lower.