The type of ligands chosen for docking will depend on the goal and it can be obtained from various databases, such as ZINC or/and PubChem, or it can be sketched by means of Chemsketch tool . For structure preparation ChemAxon MarvinSketch was used and different physicochemical properties of the ligands were collected from ChemSpider database All ligand compound saved as ligand01, ligand02, ligand03, ligand04 etc.