In the FBGA, the final score of individual i is equal to the first factor in Equation 1 which only depends on Ei. In the GBGA, this score is multiplied with a modified synthetic accessibility (SA) score, which also ranges from 0.0 to 1.0 as shown in Equation . Here, the modified SA score is the mean of the two SA scores of the ligands which are calculated as described by Ertl and Schuffenhauer and further modified using a modified Gaussian function as proposed by Brown et al. with the parameters µ2 = 2.230044 and 2 = 0.6526308 as used by Gao and Coley. Therefore, the final score in both GAs ranges from 0.0 to 1.0.