The grid spacing, level of theory, and software used were the same as Section 3.1, and there are now 576 total points on the torsion grid due to the increased dimensionality. The scan is initiated from a single structure near the energy minimum where (φ, ψ) = (-83 • , 62 • ). While the results appear similar in the low-energy region near the starting structure, there are major differences in the more distant regions of the energy profiles. Namely, the serial scan results include several high-energy "islands" in excess of +25 kcal/mol, whereas the TorsionDrive scan results have much lower energies in these regions. The sequential scan results also contain more sharp differences in the energy between adjacent grid points, for example near (+90, +90) • in Figure (c), whereas the TorsionDrive energy profile is smoother. Some of the most significant differences between the potential energy surfaces are highlighted by the starred regions, indicating that both sequential scans visited higher-energy local minima compared to the wavefront propagation scan. These results show that serial scanning poses an increased risk of providing incorrect or insufficient data compared to wavefront propagation scanning for parameterizing force fields in simulations.