To test our predictions, we experimentally investigated the solubility of limonene and benzaldehyde in organic solvent/water mixture systems. Datapoints marked in blue (Fig. ) are the organic solvents that we selected for experimental validation. We selected the solvents that are within the miscible area, commercially available, and to represent a distribution of their predicted solubility (i.e., not only the highest ranked organic solvents). We chose the volume percent of the organic solvent/water mixture systems for experimental testing as described in the methods section of the supporting information. Briefly, for a given organic volume percent (V%) in water the concentration of limonene or benzaldehyde was increased until the solution became cloudy (i.e., the cloud-point method). Examples of experimental solubility determination by the cloud-point method are shown in Fig. . We found that 80 mM limonene in 75V% acetic acid/water (Fig. ) and 140 mM benzaldehyde in 15V% acetic acid/water (Fig. ) produced clear solutions whereas 20 mM increment in both limonene (Fig. ) and benzaldehyde (Fig. ) concentration gave cloudy solutions. Consequently, we noted the highest concentration of both limonene and benzaldehyde without any cloudiness for maximum solubility in the acetic acid/water mixture as 80 mM and 140 mM, respectively. To account for the potential variability of the experiment, we conducted a total of three measurements for each case of molecule of interest and each V% of organic solvent/water mixture. While for some mixtures we observed minor variability, for most cases the observed solubility was the same. The recorded solubility values are given in Table .