Enzyme immobilization on membranes is a particular case which deserves attention, as it additionally offers the possibility to perform biocatalytic reactions along with membrane separation, in a one-pot fashion. For example, the removal of a product can favorably shift the biocatalytic reaction equilibrium toward product formation and hence increase the reaction yield. Also, membranes can be used to introduce one of the reagents at a controlled rate, to avoid enzyme inhibition. The coupling of biocatalytic reaction with membrane operation in so-called "enzyme-membrane-reactors" (EMR) has the potential to intensify biocatalytic processes. Typically, membrane separations require only a limited amount of energy with respect to other unit operations . Furthermore, membrane-reactors display relatively easy reactor operation and modulation, as well as straightforward scale-up to large systems 8, 30-32 . Thus, integrated hybrid processes allowing to simultaneously perform flow biocatalytic reactions and product separation (e.g. to drive the equilibrium) or controlled substrate addition, are of particular interest for the pharmaceutical industry, as they can help reducing the need for additional downstream steps typically required to obtain pure APIs .