These different research results indicate ORF7a has a variety of biological activity. So it requires in-depth study of its structure and function. The activity regulation of CD14 + monocytes is usually associated with endotoxin (lipopolysaccharide, LPS). The ABC transporter-dependent mechanism of lipopolysaccharide biosynthesis is a widespread form . In humans, 14 ABC-related genes have been reported to be causally related to human diseases, including persistent and hyperinsulinemic hypoglycemia . The SARS-CoV 7a protein is a type I 122-aa membrane protein . The extracellular domain has a typical 7-strand β sandwich fold and a flexible and unstructured region of the immunoglobulin superfamily . The ORF7a protein of SARS-CoV-2 has a similar three-dimensional structure, with residues 80-83 spanning the aa lumen domain . These cavities suggest that ORF7a may have the function of transmembrane molecular transport. Therefore, we believe that ORF7a may have the function of ABC-transporter.