The standard binding free energies across all host-guest systems with detectable binding range over 10 kJ/mol, but the binding enthalpies range much more widely, from -38.3 kJ/mol to -12.6 kJ/mol. The change in enthalpy favors binding in all cases, though. The small range of the binding free energy and the large range of the binding enthalpy imply the presence of entropy-enthalpy compensation within the dataset. This results, frequently observed in many other systems but, arguably, not yet fully understood , is illustrated in Figure , where the present data are displayed along with those from a prior ITC study from our lab.