The absolute free energies of the solids were calculated from trajectories of simulation boxes with 64 ASA molecules, 100 OPLS methanol molecules, and 864 argon atoms with periodic boundary conditions. ASA's unit cell was obtained from Mercury CSD 3.8 and the fcc argon crystal was obtained from the literature . Simulation box sizes were chosen to be approximately between 2 nm and 3 nm to ensure that box sizes were large enough that atoms and their periodic copies were not within cutoff distance of one another. α-methanol's crystal was obtained from the Supporting information of Aragonès et al. We used Amber14's ambertools and ParmEd to generate the ASA's and argon's solid state input files. All atoms but one were subjected to harmonic constraints in the x, y, and z coordinates. A single atom was kept fixed in space to act as the reference point for the calculations, as explained in the Introduction.