). Due to the good photostability and the presence of readily derivative carboxylate groups on these molecules, they may serve as fluorescent probes and warrant further investigation. To further illustrate the potential application of this approach, readily available BFR 4 was efficiently converted to tetrasubstituted alkene 5 under the standard conditions. Subsequent reduction and chlorination steps yielded compound 6, which could then be further transformed into the anti-cancer drug Etacstil 8 via a Heck reaction followed by hydrolysis, or into Toremifene and Ospemifene via documented cross coupling reactions (Fig. ).