As mentioned earlier, the W5 WATERGATE and PSYCHE pulse sequence elements have been combined previously, by concatenation, for benchtop NMR. Although such methods can provide excellent solvent suppression, placing the WATERGATE block before the PSYCHE element (see Supporting Information, Figure ) causes extra, unwanted scalar coupling evolution. This leads to signal discontinuities in the constructed interferogram that Fourier transform to give large undesirable chunking sidebands (see Supporting Information, Figures ). A possible remedy would be to use the perfect-echo version of WATERGATE in a concatenated WGn/W5n-TSE-PSYCHE experiment (see Supporting Information, Figures and). This would give lower SNR than PSYCHE-iWG, but could be preferable in the presence of strong coupling.