We developed a computational model of the replication mechanism which considers the key components of the system: precursors (simplified by only considering the trimers), hexamer replicators (the most commonly observed ring size in our experimental systems) and fibers formed by the assembly of hexamers. The model was developed for a system of two building blocks (A and B). The model includes how trimers from solution bind to fibers, the conversion of these trimers into hexamers, and the assembly of these hexamers on the exposed fiber end (Figure ). We also modelled the system replicating without binding of precursors to the replicator assemblies, by setting all the rate constants related to precursor binding to 0 and by allowing hexamers to be formed directly from the trimers in solution. We focused on the initial stages of replication, where only a small amount (10%) of precursors is consumed. This approach avoids that replication becomes limited by precursor availability. In line with that, reactions are modeled only in their forward direction.