Using various computational techniques to answer our hypothesis, I created a viable antibody candidate for H. pylori in this research work. Our most appropriate candidate antibody was 4a6y due to its high hydrogen bonds, low binding energy, and exceptional binding to the HpaA protein. I characterized the structure and binding of HpaA and antibody complexes using computational techniques. This will highlight the potential of 1IL1 antibody as a therapeutic agent because of its strong binding affinity, high hydrogen bond, and suitable binding site interaction.