Two types of fingerprints were investigated as potential reaction representations, the differential reaction fingerprints (DRFP), and the differential Morgan fingerprints. Both belong to the family of circular fingerprints, where the chemical information of the surrounding atoms up to a radius r is encoded as a machine-readable representation. The DRFP algorithm creates a binary fingerprint based on the symmetric difference of two sets, containing the circular molecular n-grams generated from the molecules listed left and right from the reaction arrow, respectively. The Morgan fingerprints of the reaction SMILES were computed by subtracting the molecular fingerprints of the reactants from those of the products.