o Sonoporation involves ultrasound waves creating temporary pores in the cell membrane, facilitating the uptake of CRISPR components. It has been used experimentally in tissues like muscle and tumor tissues. It has also shown promise in delivering therapeutics across the bloodbrain barrier. Non-invasive, limited to tissues accessible by ultrasound. • In general, viral vectors (AAV, lentivirus, adenovirus) and some non-viral vectors (LNPs, polymer nanoparticles) have been explored more than other methods of delivery. • Among the physical methods of delivery, electroporation co-occurs to a higher extent as compared to all other methods for most diseases except for liver diseases. • Some of the highest correlations are between ocular diseases and AAV, cancer and lentiviral vectors, and liver and cardiovascular diseases and lipid nanoparticles.