The original 101,017 small molecules were made available to participants in a training set of 70,710 compounds with activity data and a test set of 30,307 compounds without activity data. A public performance score based on a subset of the test set was published immediately after submission. The competition was evaluated using the performance score based on the remaining test set data, which was made public only after the end of the challenge. The two evaluations involved the creation of two sets, the leaderboard set and private set, which combined contained a total of 30,307 test set compounds. Randomly stratified sampling was used to ensure that the same fractions of low, medium, and high soluble compounds were present in the training, leaderboard, and private sets. The challenge participants were limited to one submission per day and per team, and each participant was required to join only one team during the challenge, which ran from September 19th to December 31st. As a result, each team had a maximum of 102 submissions at their disposal. Our team submitted a total of 18 predictions during the competition, which were evaluated based on the performance score of the leaderboard set. After the challenge ended, participants were allowed to submit new predictions, and the scores for both the leaderboard and private test sets were made available immediately. These scores were used for the majority of the analyses reported below.