The AdSoS method is a novel adaptive-resolution scheme, which distinguishes itself from previous approaches by relying on a continuum of CG models of increasing graining levels, that are entirely defined by a scaling of the reference FG model. Thus, the increase in graining is not obtained by grouping atoms or molecules into beads, but by scaling the atomic parameters of the FG solvent molecules. This approach relies on the fact that in empirical term-based force fields, the potential energy is a sum of terms (e.g. covalent, pairwise non-bonded) each characterized by a well-defined dimensional scaling.