As mentioned above he concept behind the QFVina and QFVinardo docking schemes is to decouple the complex tasks of finding physically feasible low-energy conformations and accurately estimating conformational ranks and strain energies from the docking process. These tasks are handled separately using more reliable QM calculations, which have a better chance of achieving these goals accurately. Once such QM-based conformation libraries are prepared, the AutoDock Vina program can be used for docking by considering all conformations of all ligands in the given QM conformational database as rigid ligands, serving as an alternative to flexible ligand docking. The protein target can be either rigid or flexible, as in traditional AutoDock Vina docking; however, this first version of the software focuses on rigid protein docking.