Indeed, QUBE was originally developed to provide, by construction, a compatible protein and small molecule force field for computer-aided drug design, where an accurate surface electrostatic potential of the protein is crucial. In this regard, the absolute binding free energies between the L99A mutant of T4 lysozyme and six benzene analogs have been recently computed using QUBE with a mean unsigned error of 0.85 kcal/mol, which compares very favorably with OPLS-AA/M (1.26 kcal/mol). Although further work is required to establish this accuracy across a significantly wider range of protein-ligand complexes, the promise of these initial biomolecular simulation results indicate a viable pathway toward improved protein dynamics and interactions using quantum mechanical bespoke force fields.