In the solvent-scaling approach, the CG representation of a given FG solvent model is defined as a "blown up" version of this FG model. The transformation is controlled by the scaling parameter s, which defines the amount of (isotropic) stretching in the effective size of the molecule along each Cartesian dimension. The value s = 1 corresponds to the original FG model, while values s > 1 lead to a continuum of CG models with increasing graining levels N G = s 3 . In the context of a molecular solvent, the number N S of interaction sites is preserved as well as their angular geometry, while the effective size is increased via a scaling of the bond lengths and van der Waals radii. The parameter scaling also affects the atomic masses and partial charges.