Given the specificity that deglucuronidation-through-inflammation affords, and the putative validity of aggregation-based nonspecific binding mechanisms, the standard practice of applying aggregate-dissociating detergents such as Triton X-100 is called into question for antiviral assays of phenols that are known or expected to act through the DTI mechanism. A revisiting of relevant results of in vitro assays in the literature where such a detergent was applied would be appropriate. However, such a modification to laboratory practice should be considered carefully as the tendency for an aggregation to bind assay-specific enzymes could still benefit from detergent application.