The ability of the coacervates to encapsulate curcumin was assessed. Curcumin is a compound that is commonly taken as a dietary supplement due to its health benefits and low bioavailability from food sources. To increase its bioavailability, curcumin can be administered in emulsions or along with piperine, a compound that blocks its metabolism in the body. We investigated the ability of the coacervates to encapsulate curcumin as well as piperine. Curcumin was shown to be effectively encapsulated in the coacervates with a high encapsulation efficiency percent (%EE) of 96±3% due to its low water solubility (Figure ). Piperine, which is ~26 times more water-soluble than curcumin according to the ALOGPS software, was encapsulated less effectively with an %EE value of 41±6%. Nevertheless, the lower %EE for piperine can still increase the bioavailability of curcumin and these values indicate that the peptide coacervates could serve as a useful means to provide curcumin as a dietary supplement.