Radii of gyration values are determined in order to understand the compactness and dynamic stability of drug-DNA complexes . Radius of gyration was calculated through gmx_gyrate programme inbuilt in GROMACS software. The average radius of gyration for both the complexes falls between 1.275nm and 1.475nm, respectively. The collective radius of gyration variations is shown in figure . These variation results reveal that DNA in both the complexes remains compact for the whole 5000ps molecular dynamics simulation and hence claims for the stability of the complex . Hydrogen bonds are important parameters in the determination of specific binding sites in DNAligand interactions. Figure depicts the variations in the number of hydrogen bonds being formed and broken during the molecular dynamics trajectory for 5000ps. The same figure also shows that complex-1 forms a maximum of 4 H-bonds whereas complex-2 forms a maximum of 8 H-bonds. This suggests the stronger interaction between DNA and ligand in complex-2. Thus, the overall results of hydrogen bonds suggest that complex-2 could act as better antimicrobial agents on account of previous results. Root Mean Square Deviation RMSD is considered as the measure of the conformational stability of the complex during the course of molecular dynamics simulation . Here, our interest lies in examining the conformational stability and dynamical effect of ligand-DNA complexes and hence to determine the most stable complex amongst the two. The plots for RMSD of both drug-DNA complexes are represented in figure 16. In the variations shown below, the RMSD for both complexes are similar and thus both of them claim towards the stabilization of the complexes. However, complex-2 shows consistency in the variations which is missing in that ofcomplex-1 and this adds to the benefit of the results obtained in favor for complex-2.