The Protein Data Bank (PDB ID = 1FJE) was the source of the receptor's threedimensional structures . The aptamer's main nucleotide sequence underpinned structural predictions. Vfold2D first determined this sequence's secondary structure . After obtaining the nucleotide sequence, it was converted to a secondary structure, and the images are in Figure . After predicting the secondary structure, the tertiary structure was modeled using Vfold3D . ChimeraX visualized the 3D structures that were obtained . These 3D structures were docked on nucleolin protein by the HDOCK software . The complete singular structure of DNA-bound nucleolin protein was obtained from AlphaFold 3 , a deeplearning model that predicts the 3D models of the protein and DNA.