To further test how the new AMC-xTB model fares in cluster configurational sampling, we tested the independent and improvement workflow for several previously studied (acid) 4 (base) 4 cluster systems. Hence, the workflow is tested on clusters up to twice the size of those used in the reparameterization. and) and two new multi-component AM clusters sampled in the same way as Knattrup et al. (d and e). Gibbs free energies are calculated at the ωB97X-D/6-31++G(d,p) level of theory with the quasi-harmonic approximation (cutoff of 100 cm -1 ) and vib. frequencies scaled by 0.996 in accordance with Kubečka et al. Figure shows the difference in binding free energy for the lowest free-energy configuration found by employing the independent and improvement workflows for the (SA) 4 (EDA) 4 , (SA) 4 (AM) 4 , and (SA) 4 (AM) 1 (MA) 1 (DMA) 1 (TMA) 1 clusters compared to Kubečka et al. and the (SA) 1 (MSA) 1 (NA) 1 (FA) 1 (AM) 4 and the new (SA) 1 (MSA) 1 (NA) 1 (FA) 1 (AM) 1 (MA) 1 (DMA) 1 (TMA) 1 clusters sampled in this work. The SA-AM clusters have been extensively studied previously and are therefore believed to be well-sampled using the original configurational sampling procedure and thereby difficult to improve. Still, the new CREST+AMC-xTB methodology manages to find cluster structures lower in free energy by 0.21 kcal/mol compared to the previous works.