Next, we explored the compatibility of our trifluoromethylamination protocol with various classes of electrophiles. The NCF3 fragment, bearing different protecting groups, was successfully installed in benzylic and allylic motifs in only 2 hours at 80 ºC (Scheme 1, entries 24-26). Notably, our methodology proved also compatible with the direct introduction of isotopically labeled 15 NCF3(PG) fragments by starting from a 15 N-labeled precursor (Scheme 1, entry 27). For this transformation, both the generation of the anion and the substitution step were performed in batch, highlighting the generality of our approach, which extends beyond flow setups. Next, both primary and secondary alkyl iodides underwent efficient trifluoromethylamination, albeit requiring the use of silver triflate and extended reaction times (Scheme 1, entries 28-30, see Supplementary Information for detailed reaction conditions). Nitrogen-containing heterocycles and acetyl-protected galactosyl bromide (Scheme 1, entries 31-33) were also obtained in moderate to good yields. Finally, we applied this protocol to various API intermediates, including those derived from densely functionalized Ticagrelor, a Lonazolac analogue, Pitavastin, and Umifenovir (Scheme 1, entries 34-40), demonstrating its compatibility with complex molecular architectures and its ability to incorporate different Nprotecting groups.