Several brodifacoum-derived libraries were then generated by different criteria. A higher relative weight (x4) was chosen for best fitting to the brodifacoum-cavity to select those with higher affinities. To reduce the numbers of children with undesirable unspecific properties, those with lower hydrophobicity were preferred using logP values <3 but limited by selecting a relative weight of only x1. Preferentially lowering the children hydrophobicity should contribute to reduce hydrophobic-dependent toxicities and unspecific off-target effects, facilitate their handling by increasing aqueous solubilities and most probably, could favor bait taste. To explore and optimize possible affinity effects on the generated children, the "create compound like: approved drugs or natural products" (DWdependent), the different molecular weight preferences (user-dependent), and the number of runs (user-dependent), were varied.