From the KDE plots, there seems to be three distinct groups based on distributions of PDB proteins (narrow compact range with Porod exponent > 3.0), copolymer backbones and PEG-SCNPs (with extended conformation and Porod exponent ≤ 2.0), and EPO-SCNPs and WDCL-SCNPs (favor compactness with a broad range of flexibility and intermediate Porod exponent from 2.0-3.0). The data also indicates that peptidic side chains seem to shift copolymer behavior closer to that of proteins in terms of both Rg/Rh and Porod exponent (Figure ).