However, even with this imposed limitation on the virtual transformations, some transformations afford more than one product, on average, per starting material. The ratio of unique products generated to the number of starting molecules for each transformation was determined as shown in the heatmap in Figure for the Enamine database. This increases the number of both known and unknown products generated in these transformations. However, the increase in the number of unknown products generated is generally higher than the increase in the number of characterized products in these cases. As such, the number of uncharacterized compounds a transformation generates can be a misleading metric. With this in mind, we sought to identify a more objective metric of the value of different virtual skeletal edits.