In this article, we created a novel biocompatible hydrogel based on precursors functionalized Dex-Mal and HA-SH through the Michael Addition. Both were characterized using NMR, which indicated that they were synthesized successfully. The hydrogels were characterized by gelation time, swelling studies, viscoelastic properties, degradation rate. According to gelation time study, the best formular is 2% Dex-Mal and 2% HA-SH. As a consequence, this formular was used for the remaining studies. The swelling study shows that the hydrogels have good flexibility to mimic extracellular matrix. The degradation study shows that the hydrogels will be degraded completely after 9 days. The viscoelastic study shows that the hydrogels are formed by Michael Addition are elastic solid. Based on the above evidence, this novel biocompatible hydrogel could be potential for the biomedical applications.