A further advantage of the OpenTrons OT-1 is the small footprint. The unit can be easily contained in a single fumehood and automated protocols run for every stage of the synthesis (stock solution preparation, reaction set-up/running, work-up, final sample solution preparation, and QC sample preparation). In contrast, a classical synthetic approach would require substantial levels of equipment and space to optimise the library synthesis and almost continual operation by the chemist/chemists in the project team.