For example, in Figure the main product temperature range for paracetamol synthesis was calculated as 1 -64 °C and no catalysts or special processes were specified. In the case of Figure , the impurity reaction is deemed valid it occurs within (overlaps with) the temperature range of the main product (ambient temperatures are assumed here to be 20 ℃), and does not require special processes or any catalysts. On the other hand, the impurity reaction shown in Figure and invalid example (filtered out) respectively.