Fungal enzymes, such as laccases, peroxidases, and cytochrome P450s, have been increasingly recognized for their significant role in the biodegradation of xenobiotics. Among these enzymes, laccases have attracted growing attention in the bioremediation study due to their high reactivity and substrate versatility. Yet, a major setback of applying free laccase is the fast loss of enzymatic catalytic performance and stability when encountering environmental factors such as varied pH and fluctuating temperatures. To address that, the enzyme immobilization technique has been employed, which entails attaching, crosslinking, or entrapping enzymes onto a solid substrate or within a porous support matrix. Undergoing immobilization is expected to render several advantages over free laccases: (1) improved tolerance to harsh environmental conditions, including extreme temperatures and pH levels; (2) easy recovery of enzymes from treated wastewater or contaminated sites; (3) retained and augmented catalytic ability for targeted compound degradation. To successfully synthesize powerful immobilized laccases, selecting the appropriate supporting materials is a crucial aspect. We envision that boron nitride nanosheets (BNNSs), also known as "white graphene", are promising for laccase immobilization. BNNSs consist of a few atomic thickness layers of bulk hexagonal boron nitride (hBN) and resemble structures of graphene, with B atoms and N atoms substituting for C atoms. BNNSs offer several advantages for enzyme immobilization and environmental applications. BNNSs showed higher surface areas than hBN (BNNSs: ~2,600 m 2 g -1 ; bulk hBN: ~10 m 2 g -1 ). Additionally, the remarkable chemical stability of BNNSs makes them suitable for use in a wide range of environments. Their high biocompatibility reduces concerns of secondary contamination. In order to enable better enzyme attachment on BNNSs, the exfoliation and functionalization process during the BNNSs synthesis is necessary for increasing BNNSs solubility and providing covalent binding positions.