The reactor platform consists of two Vapourtec R2 modules for controlling flow rates, a Vapourtec R4 reactor module for controlling reactor temperature, a Gilson GX-271 liquid handler for dispensing and collecting reaction material and LC-MS analytical equipment (Shimadzu/Waters) for reaction outcome determination. For each reaction, with the experimental conditions determined through LHS or algorithmically, the liquid handler dispenses 2 mL slugs of the starting material (in this case, the chloroacetanilide 15) pre-dissolved in the selected solvent into the sample loop for pump A -this solution also contains biphenyl as an internal standard. The selected catalyst/ligand combination in the same solvent is then loaded into the sample loop for pump B, and the solvent of interest is loaded into pump C for dilution. The reaction is conducted with a constant 0.09 M reactor concentration, yielding the corresponding product (in this case, the oxindole 16), which is thereby analyzed utilizing a 4-way switching valve for on-line LC-MS. Using this methodology, experiments can be run using only minimal amounts of reaction material for each experiment as we are utilizing reaction slugs. This experimental workflow is illustrated in Figure .