Stringent regulations apply to the production and marketing of pharmaceuticals, to ensure that any adverse effects from their use are identified and minimized. Typically, full characterization of all active pharmaceutical ingredients (APIs), excipients, and impurities is required for components in excess of 0.1%. H solution-state NMR spectroscopy is widely used for characterization and quantification purposes in these cases. Chemical shift information and scalar coupling constants are frequently used in NMR spectroscopy to aid molecular structure elucidation. However, for complex systems such as pharmaceutical formulations, H NMR spectra are often complicated by low chemical shift dispersion, signal multiplicity patterns, and the concentration disparity between major compounds and impurities, which combine to cause significant spectral overlap and hinder spectral analysis. H NMR spectra are particularly complicated by the presence of intense signals from non-deuterated solvent (such as H2O), where the high dynamic range between the intense solvent signal and weak solute signals makes the latter difficult to observe. Pharmaceutical formulations, metabolomic samples and biological samples are routinely analyzed in non-deuterated solvents either to mimic in vivo conditions, to retain signals from exchangeable protons, or to avoid perturbing the system of interest (for example to avoid denaturing proteins). 1 H NMR spectra can be simplified by acquiring spectra containing only chemical shift information, using 'pure shift' experiments. These increase spectral resolution by collapsing multiplet structure into a single line at the chemical shift of each proton environment. There are multiple types of 1D 1 H pure shift experiment which differ in the treatment of active (observed) and passive (coupled) spins. A J-refocusing element, comprised of a hard 180° radiofrequency (RF) pulse and an active spin refocusing (ASR) element, when placed in the middle of an evolution time refocuses the scalar coupling evolution of active spins while allowing the chemical shift to evolve. High sensitivity pure shift spectra can be obtained using a homonuclear band-selective decoupling (BS) ASR element. Broadband homonuclear decoupled spectra can be acquired using the Zangger-Sterk (ZS), bilinear rotation decoupling (BIRD), or pure shift by chirp excitation (PSYCHE) ASR element, but all three have an intrinsic sensitivity penalty. For samples prepared in non-deuterated solvents, additional manipulation of the nuclear magnetisation is necessary to suppress the large solvent signal. For samples with strong signal intensities, radiation damping becomes a significant problem and can cause intense artifacts throughout the spectrum acquired if adequate solvent suppression is not performed. A common solution to this problem is to use presaturation, to saturate and remove the large solvent signal(s). Although presaturation methods achieve good solvent suppression, signals from nuclei in chemical exchange with the solvent are also saturated, so are strongly attenuated. This unwanted signal suppression is also observed with the NOESY-presaturation method, which has recently been combined with pure shift techniques. Furthermore, presaturation requires a long, lowpowered continuous wave RF pulse applied during the recovery delay of the NMR experiment in order to saturate the solvent resonance, which can lead to an undesirably long experiment time.