For each detected similar compound 𝑠 " ∈ 𝑆, all reactions 𝐽 that produce the compound 𝑠 " in KEGG reaction database are found. For each reaction 𝑗 ∈ 𝐽, excluding cofactors and free metabolites from the reaction participants, one-to-one wiring (reactant 𝑟 ",$ -to-compound 𝑠 " ) reactions with only metabolites involved in efficient carbon flux are determined, and defined as a referenced analogue reaction 𝑗. The full list of one-to-one wiring reactions can be found in Section S3 of ESI.