Since particles are highly diluted during purification, we propose centrifugal filter devices (CFD) with a 10 kDa membrane of regenerated cellulose for concentration. A cut-off of 10 kDa corresponds to 1 nm pore sizes, ensuring full particle retention. To validate the suitability of these CFDs to concentrate C/S particles, we performed concentration experiments with C/S particles diluted in water (red) and eluent (blue), respectively (see Figure ). In this context, we use the absorbance at 641 nm to measure the C/S particle concentration and recovered 63% for particles diluted in water. Particle losses occur due to irreversible adsorption of particles on the membrane rather than due to 20 nm particles passing the filter pores of 1 nm diameter. We observe two overlapping mechanisms in the sodium azide solution: particle loss due to irreversible adsorption and C/S disassembly. Please note that C/S disassembly in salt solution is heavily time-dependent, as documented in Figure . We suggest a disassembly mechanism in which charged ions diffuse into the gaps between core and satellite particles and, thus, disturb the electrostatic assembly between the two species. While PEGylation is an appropriate approach to prevent degradation of particles during the AFFF run , the PEG shell is not complete and rigid enough to avoid ion-induced disassembly. With this, we demonstrate the importance of fast AFFF runs and keeping the ionic strength as low as possible. Additionally, a combination of a silica and PEG shell should be taken into consideration to avoid ion-induced disassembly.