Subsequently, the substrate scope of this C-H biarylation was explored (Figure , right). The results revealed that this C-H biarylation could be applied to various biaryl iodide derivatives. In order to synthesize non-natural derivatives of tyrosine, C-H biarylation was attempted using a substrate in which the OMe group was replaced by a methyl group. As a result, compound 39 was successfully obtained in 70% isolated yield. Furthermore, the reaction was applicable to the synthesis of compounds 40 and 41, which are fluorinesubstituted compounds playing an important role in the field of medicinal chemistry.