To compare the e ect of hardware on partial charge generation, we charged the same conformers using AmberTools AM1-BCC charges on Intel and M1 Mac processors. We generated 50 conformers for each of the 6 molecules from the 15 PLB molecules (Section 2.6.1) using rdkit v2024.03.2 conformer generator 37 on an M1 Mac processor. These conformers were saved within multi-conformer molecules in the oeb.gz format. We loaded in the multi-conformer molecule oeb.gz files and charged each of the 50 stored conformers for each molecule using AmberTools AM1-BCC partial charges on an M1 Mac processor. We then replicated this process and loaded in the multi-conformer molecule oeb.gz files, then charged the same 50 conformers for each molecule using AmberTools AM1-BCC partial charges on an Intel processor. We compared the set of partial charges generated for each conformer on the M1 Mac processor versus the Intel processor using the metrics in Section 2.5.