The discussed principle of mechanistic transferability has also been employed outside of CPA catalysis, with a focus on amine-based hydrogen-bond donors, for example imidodiphosphorimidate type catalysts for the construction of THF and THP rings (Figure ). Werth and Sigman In the authors' perspective, the exploitation of the concept of mechanistic transferability is a promising avenue for the application of ML in enantioselective organocatalysis, as combining data from multiple reactions enlarges datasets. As such, it is an important stepping stone towards the development of more generally applicable models.