Data from each assay were normalized plate-wise to corresponding intra-plate controls as noted above. The same controls were used for the calculation of the Z' factor, a measure of assay quality control. Concentration-response curves were fitted and classified as described previously . IC50's were calculated using Prism software (version 8.1.2, GraphPad Software, Inc.), sigmoidal dose-response (variable slope). We used the Palantir Technologies (Washington, DC) data integration platform, which is configured to ingest all HTS results generated at NCATS and harmonized this data with other sources such as ChEMBL and OrthoMCL. All qHTS screening results are publicly available at PubChem. The chemical structures were standardized using the LyChI (Layered Chemical Identifier) program (version 20141028, ) .