A similar asymmetric catalyst design platform is CatVS/Q2MM (Box 3), primarily focused on organometallic catalysts. Like VIRTUAL CHEMIST/ACE, CatVS/Q2MM is an MM-based method and was first benchmarked on known metal-catalyzed reactions (see Box 3), followed by its application in a "real-world" scenario, which yielded stereoselective ligands for the Rh-catalysed asymmetric hydrogenation of enamides (discussed in more detail in the Evaluation of the Models, Methods, and Applications section).