To accurately reflect the diversity among bacterial strains and species, it is crucial to develop more sophisticated bacterial membrane models, informed by lipidomics studies. Incorporating cyclopropane-containing acyl chains, branched acyl chains, lysyl lipids, and glycolipids in varying proportions enables the modeling of different bacterial species and strains, distinct phases of the cell cycle, and the states associated with AMP susceptibility or resistance. Similarly, the extraordinary variability of lipopolysaccharides (LPS), with their numerous resistance-inducing modifications, must be captured to study their role in adaptive mechanisms. These enhanced models would also facilitate investigations into membrane domains, which play critical roles in various cellular processes , including AMP-induced domain formation as a mechanism of membrane disruption .