Among all the consensus strategies explored (as reported in Table ), averaging the ranks of compounds obtained with DiffDock-L+Gnina and Vina+Gnina performed the best. With an average BEDROC score of 0.38 and an average EF1% of 19.33 across the 43 targets, this consensus approach surpassed the VS setups using either DiffDock-L or Vina individually. The consensus scoring method achieved, on average, the highest ratio of active scaffolds (21%) among the top 1% of ranks. Additionally, it increased the number of targets for which BEDROC scores of ≥ 0.5 were reported from 12 (the highest number achieved by the individual VS setups) to 17.