The associated diseases include ulcerative colitis, Crohn disease, multiple benign and malign tumors, Lynch and Hirschsprung disease, and several additional inflammatory and metabolic diseases. As a matter of fact, the associated disease most significantly overrepresented in this subset of 454 targets in a Fisher exact test, among all set of all associated diseases in PHAROS, is "ulcerative colitis" (Benjamini-Hochberg adjusted pvalue = 2e-78), followed by "malignant colon neoplasm" (adjusted p-value = 6e-54) , "cancer" (adjusted p-value = 9e-47), and "colorectal cancer" (adjusted p-value = 2e- 35). By including some additional targets recently identified to be of biological relevance in the microbial-host communication, although yet to be associated with intestinal diseases, this results in a set of 467 "high-priority" proteins where to focus experimental efforts. These interact with a total of 392 metabolites. The largest share of metabolites in this "high priority" set correspond to "Organic acids and derivatives", followed by "Benzenoids", "Fatty Acyls", and "Organoheterocyclic compounds". In turn, the target classes most abundant in this set are "Other", "7TM1", "Protease", "Oxidoreductase", and "Enzyme other". A total of 2804 predicted interactions are present in this "high priority" set, thus providing a large number of hypothesis to test through fast, focused in vitro assays.