The transcription factor IIIC subunit 5 HTH (IPR019136) is involved. An important DNA-binding protein called transcription factor IIIC (TFIIIC) acts as a moving platform for the assembly of preinitiation complexes at classification III genes. It is the Tfc1/Sfc1 subunit, also known as the tau 95 subunit, and it occupies a critical position in TFIIC. It has both upstream and downstream effects on the TFIIIC-DNA complex, reducing its instability. Once TFIIIC binds to promoter elements within tDNA genes, it guides the assembly of TFIIIB on DNA, which in turn recruits RNA polymerase III (pol III) and initiates multiple transcription cycles.