Previously SAMPL challenges have included a variety of host-guest systems, but the majority of SAMPL hosts have been in the cucurbituril and Gibb deep cavity cavitand (often called "OctaAcid") families thanks to the contributions of Lyle Isaacs and Bruce Gibb's labs. There have been several analogs of these two families since host-guest systems first appeared in SAMPL3. SAMPL7 includes several analogs in the cyclodextrin family thanks to Michael Gilson's lab.