On a broader level, we demonstrate the versatility of benchtop heteronuclear NMR spectroscopy as a quantitative analytical tool for the mechanistic investigation of complex reaction mixtures, and we envision this workflow might be applied to the investigation of other mechanistically complex chemical systems or to flow chemistry for real time reaction monitoring on scale, ultimately providing access to rapid reaction optimization for medicinally relevant small molecule scaffolds. Such studies are currently underway in our laboratory.