In conclusion, we have advanced a strategy that can be used to establish the chemical principles that underlie electronic quantum coherence loss in molecules. Previously inaccessible fundamental questions such as how chemical functionalization or solvent character con-tribute to the overall electronic decoherence, or how to develop chemical strategies to rationally modulate the decoherence can now be systematically addressed. The strategy is based on reconstructing spectral densities from resonance Raman experiments on molecular chromophores in solvent, and using the theory of decoherence functions to decompose the overall decoherence dynamics into contributions by individual solvent and vibrational modes, thus establishing decoherence pathways in molecules.