FC relaxometry measurements of water solutions provide the relaxation rates of solvent nuclei, which are enhanced by their intermolecular interactions with the macromolecules present in the solution. In diluted water solutions of diamagnetic macromolecules, the dynamics of the water molecules on the coordination surface of the macromolecules, or transiently trapped into their cavities, is slowed down. Therefore, the proton dipole-dipole interactions of these molecules are modulated with a correlation time given by the shortest between their lifetime onto the macromolecule surface and the reorientation time of the macromolecule. In the presence of internal (local) dynamics, the time constant of the occurring faster mobility can also act as a limit for the correlation time. Chemical exchange allows for the propagation of the relaxation enhancement of these surface water molecules to the bulk, as well as of the exchangeable protons of the macromolecules. In the simple case that dipole-dipole interactions are modulated by stochastic fluctuations occurring with a correlation time 𝜏 𝑐 , the relaxation rates are given by 4