The versatile biological and pharmacological activities of mangiferin and its derivatives in a range of medicinal situations, including cancer, diabetes, hypertension, depression, microbial infection, etc., have attracted a great deal of attention from researchers. Mangiferin shares a molecule that can be easily modified chemically, and by adding small chemical modifications, their pharmacological activity can be varied, even their efficiency. A significant amount of research work is in progress, and many patent applications have been filed for the physiologically active substances that contain the pharmacophore mangiferin.