In this work, we stand on the shoulders of giants in the force field development community, and it would be impossible to provide a complete list of all those whose work we have benefitted from. However, we are particularly indebted to the AMBER force field community, from which we derived the initial small molecule force fields which provided the starting point for this work. We thank the Open Force Field Consortium for funding, including our industry partners as listed at the Open Force Field website. We gratefully acknowledge Owen Madin and Karmen Condic-Jurkic for helpful discussions, along with all current and former members of the Open Force Field Initiative and the Open Force Field Scientific Advisory Board. We thank Vytautas Gapsys for assistance with the binding free energy calculations and for the insightful discussions.