The lack of congruent release at 20 wt% drug loading, is in contrast to the results of Indulkar et al and Yang et al , who obtained congruent release for RTV-PVPVA ASDs in pH 6.8 buffer at 20% drug loading (based on HPLC analysis of the dissolu on medium), and iden fied the limit of congruency to be approximately 25% RTV loading. However, substan al experimental and sampling differences were present between their and our setups, including compacts vs film, different dissolu on setup geometries and flow dynamics (including s rring vs no s rring), and 37 °C vs room temperature. Evidence that temperature significantly alters the congruence limit already exists, as Krummnow et al 10 , who also inves gated phase separa on and release from spray-dried RTV-PVPVA ASDs at 25 °C (in s rred pH 7 dissolu on medium and using UV detec on), observed incongruent and dispropor onately low drug release already at 20 wt% drug loading. This is in line with our observa ons. More generally, we also need to emphasize that our (semi-)quan ta ve analyses were not validated, and peak posi on shi s of the PVPVA signal in the film versus buffer phases (Figure ) could have affected rela ve concentra on predic ons in the buffer rich phase.