The difference between the pre-milling and post-milling plots are not as obvious as we have seen previously using this technique for the synthesis of metal-organic frameworks. In metal-organic frameworks a drastic change in the hydrogen environment occous as small molecules are converted to crystalline porous solids. In reactions i and ii the final products are still considered small organic molecules, meaning that only small and subtle changes in the T1-T2* 2D correlation plots are expected, and observed. In pathway i, the T1 goes from 38.4 s pre-milling to 13.0 s post-milling. In pathway ii, the T1 change is from 55.1 s (pre-milling without acetonitrile) to 38.4 s (dried product). The T2* values typically stay around the same value for all solid samples, usually between 4 and 11 µs. These observations are explained by Bloembergen-Purcell-Pound (BPP) theory where the T2*, governed by T2, reaches a minimum value expressed by very rigid samples, such as our solid reagents. BBP theory also explains the idea that more rigid samples have longer T1 values. This is well demonstrated in our comparison of benzil and 4,4'-dimethylbenzil. The more rigid molecule, benzil, has such a long T1 that it cannot be measured on a reasonable time scale. With the addition of methyl groups, the 1 H mobility is increased and the T1 is greatly decreased.