DW-BEL algorithms generated large numbers of random raw children and selected those fitting the protein-ligand-cavity of the corresponding target/parent pairs by co-evolution with additional user-defined preferences. For that, each individual 2D parent structure was opened from an *.sdf file with DW/File/Open, selected and copied to DW/Chemistry/BEL/Root generation compounds/from the clipboard. In these studies, each parent molecule was employed without any selection of substructures to protect them from being changed (lazo tool). Then, each of the target / parent complexes coded into *.pdb files without CONECT lines, was opened into the DW/BEL/Add Criterion/ Docking score/Load Protein Cavity From PDB-File, to select for the target docking cavity. Other user-selected Add Criterion -> were included.