Network construction for case studies Given a chemical library, hypothetical synthetic routes are proposed using ASKCOS and SPARROW. Synthetic routes are generated with the ASKCOS MCTS tree builder with the maximum price per gram for starting materials is set to be 120 USD by querying the ChemSpace () API. SPARROW is used to downselect routes using weighting factors of 50, 1, and 1 for reward-weight, start-cost-weight, and reaction-weight, respectively.