Subsequently, further biological functions of BMP2 were identified . BMP4 presents a structure 80% homologous to that of BMP2 . Several studies have similarities in the properties of BMP2 and BMP4, on physiological and pathological processes . In terms of molecular interactions, it is known that BMP2 and BMP4 interact with BMP receptors type IA (BMPR-IA) (also known as ALK3), BMPR-IB (ALK3) and BMP type II receptors, although with different affinities .