The P-score equation is inspired from the rescaling normalization equation 45 where the range of all descriptors should be normalized so that each descriptor contributes proportionately to a final score. The P-score gives an evaluation of each binding mode by the normalization of the ensemble of all descriptors; time (t) and average interaction energy (ΔE FMO ), rather than using a single descriptor (residence time (t) or interaction energy (ΔE FMO ).