To streamline the workflow of running replica exchange simulations, post-processing to decorrelate time series data and write replica/state trajectory files, and performing structural and thermodynamic analysis operations, we have provided templates in cg_openmm for setting up Signac 66 flow projects. Signac is a Python-based workflow manager, which allows the user to specify project operations and their dependencies using Python decorators. Ranges of force field and model parameters of interest are specified in a project's init.py script, and Signac manages the parameter scan directory structure, job data, and job submission on high-performance computing (HPC) clusters with minimal human input. Moreover, the Signac framework is highly scalable to very large parameter scans.