Most importantly in our context, however, these approaches were all retrosynthetic in nature, i.e. trying to answer the question for a given molecule, "can it be synthesized?" or "how do I make it?" It seemed reasonable to turn this question on its head and instead ask: "what can we easily and cheaply synthesize?" and only then "go fishing" (with all the modern CADD approaches) for bioactive compounds in such a large pool of easy-to-synthesize molecules. The forward-synthetic approach ("let's just make some molecules/libraries"), while not always clear to distinguish in existing software from retrosynthetic processing, started up nearly as early with tools such as AHMOS, CAMEO, AIPHOS etc. With this approach, one can for example a priori limit the number of reaction steps to just one, i.e. the simplest possible chemistry. The central point of SAVI is to avoid any synthetic heroics. Likewise, by giving the task of creating new molecules to the computer, one may reduce anthropogenic biases in chemical reaction choices , thus hopefully covering chemical space better.