The World health organization (WHO) report, 2020 on cancer has been disclosed that .1 million people around the world had cancer, and 9.6 million died from the disease in year 2018. It was also reported that by 2040, number of cancer patients becomes nearly double, with the greatest increase in low-and middle-income countries (LMIC), where chances of cancer are more than two thirds when compared to the worlds. Cancer is the basis of about 30 % of all premature deaths among adults aged 30-69 . According to National Breast Cancer Statistics (NBCS) report in 2020, an estimated 276,480 new cases of invasive breast cancer would be diagnosed in women in the Unites State (U. S.) as well as 48,530 new cases of non-invasive (in situ) breast cancer till year 2040. Breast cancer (BC) is most common among women's and remains a public-health issue on a global scale . Breast cancer alone is expected to account for 40 % of all cancer diagnosed in women . High morbidity and mortality rate due to cancer has motivated huge scientific interest in discovery of newer anticancer agents from natural sources . A variety of risk factors for breast cancer have been well-established by epidemiologic studies including family history of cancer, genetic traits, ethnicity, and race, as well as variable exposures of substances such as alcohol consumption, exogenous hormones, physical inactivity, and certain female reproductive factors . On the basis of molecular background, breast cancer is basically classified into three main subtypes: i) Hormone receptor-positive [estrogen receptor (ER)+]; ii) human epidermal growth factor receptor (EGFR) 2 (HER2)-positive; and iii) triple negative tumors . Initially, it was assume that estrogen receptors are responsible to stimulate the growth of breast cancer . Further studies on breast cancer revealed that progesterone receptors (PR) also play an important role in the normal development of breast during puberty and can stimulate the overgrowth of breast which leads to breast cancer . EGFR belongs to ErbB family, having tyrosine kinase receptors with growth promoting effects. It was found that this protein is expressed in several carcinomas and over expression of EGFR is a common feature of the malignant phenotype in human tumors .