PNPs have been synthesized and investigated for bioactivity before, probably driven by intuitive inclusion of NP structures in compound library design, and they define a major fraction of currently known bioactive compounds. They are strongly enriched in compounds in phases 1-4, i.e. in clinical exploration and in the market. In light of this broad historical use and success, rapid access to PNPs, preferably without the need to develop multi-step complexitygenerating asymmetric transformations, is of high relevance to future medicinal chemistry and chemical biology programs.