For in vitro experiments different cell lines were used. HeLa (human cell line derived from cervical cancer cells). Cells were cultured in DMEM media (glucose 1000 mg/L) supplemented with 10% fetal bovine serum (FBS), 1% of 2 mM L-glutamine and 1% antibiotics (100 units/mL of penicillin and 100 μg/mL of streptomycin). Cells were passaged using 0.05% trypsin/EDTA when they reached 80% confluence. Cells were grown at 37 ºC with 5% CO2. All work performed with human cells follow the ethical principles and EU Directive 2004/23/EC.