Structurally, the SARS-CoV-2 coronavirus is an enveloped virus with a helical nucleocapsid that contains one of the largest positive single-stranded RNA genomes (ca. 30 kb). The virions have ellipsoidal and spherical shape with average diameter ranges between 65 nm to 97 nm . The viral envelope is comprised of a bilayer lipid membrane that is speckled with glycoprotein spikes (S), that give the virus its crown-like appearance , membrane (M) protein, and envelop (E) glycoprotein. (Figure ). The virion contains another structural protein, known as nucleocapsid (N) phosphoprotein, which is a basic RNA-binding protein that complexes and protects the genome .