In this work, we attempt to optimize the loading and subsequent release capabilities via structural modification without comprising the direct exposure to the desired nanostructural morphology, that may facilitate cellular integration. This is achieved by the electrochemical fabrication of a novel double layer (bottle neck-like) structure (Scheme 1) whereby the first layer has the desired reduced pore diameter to control the initial burst release and encourage cellular integration but opens into a second layer with a much larger diameter that performs as the primary storage vessel. This layer is capable of accommodating more drug molecules, hence improving the loading capacity and in totality influences the release performance. The double layer modulated thickness was fabricated based on the previous works reported on TiNT and NAA that reported on the use of alternating the anodic voltage and consequently the current density resulting in a disruption of the immediate electrochemical equilibrium, resulting in a change in morphology within the anodic structure, and for the first time this phenomenon observed in TNT and NAA has been reciprocated in ZrNT [ ]. The drug release performance from this double layer structure was compared with structures bearing constant tubular length and pore-diameter.