The MiMiC framework relies on a loose-coupling approach that allows the external programs to run concurrently using their own parallelization scheme, which can be based on, e.g., MPI, OpenMP, or GPGPU. Indeed, as detailed above (see subsection 2.2), the pure QM and MM contributions are computed by CPMD and GROMACS, respectively, using their own parallel strategies. Moreover, the bonded and van der Waals QM/MM contributions, which are treated at the MM level, are also computed by GROMACS. On the other hand, the electrostatic QM/MM interactions are directly computed by MiMiC and here we describe their parallelization which is based on a hybrid MPI/OpenMP approach.