Ethylene is one of the most important bulk platform chemicals with an annual global production of 214 million tons in 2021. The industrially established primary production method is steam cracking of hydrocarbon feedstock, followed by separation and purification. In the C2 product stream after the de-ethanizer column it is necessary to reduce the acetylene content down to below 1 ppmv on the industrial scale by selective hydrogenation to ethylene. Such an acetylene removal unit (ARU) can be integrated directly after the de-ethanizer, where the C2-cut contains excess hydrogen and methane (front-end) or after the subsequent de-methanizer (tail-end). Currently the tail-end process is more commonly applied as reaction control is more convenient due to control of the hydrogen/acetylene ratio. The high hydrogen fraction under front-end conditions can decrease the ethylene selectivity and increase the risk of hot spot formation or even reactor runaway and thus, renders the process control more challenging. With a suitable catalyst and safe operations, the excess amount of hydrogen in the front-end integration is advantageous because then a higher conversion of acetylene as well as the suppression of oligo-and polymeric byproducts ("green oil" / C4+ hydrocarbons) can be achieved. Additionally, this reduces catalyst deactivation and results in a longer catalyst lifetime. Furthermore, with the front-end method the removal and subsequent addition of hydrogen becomes obsolete because the hydrogen produced during steam cracking is used within a more efficient process integration. For both process options the state-of-the-art catalysts are palladium/silver nanoparticles supported on alumina pellets. However, due to the importance of the reaction, there has been a lot of research with focus on enhancing catalytic properties for palladium catalysts or even developing new catalysts. Here metal-organic frameworks (MOFs) with their chemical versatility, high surface area and pore size variability, offer the possibility of directing selectivity and enhance the activity of the selective acetylene hydrogenation. Recent studies on this reaction with specially designed MOFs for the separation of acetylene and MOFs as catalysts, e.g. with open Fe III sites, show promising results. Research on palladium catalysts supported on MOF structures has also been in the focus with Pd supported on MOF-5 , Pd/UiO-67 , Pd@Mil-53 or Pd@ZIF-L . To the best of our knowledge, no studies on acetylene hydrogenation with favourable Pd 2+ nodes as part of a MOF itself have been reported, yet. [Pd(2-pymo)2]n (2-pymo = 2-pyrimidinolate) is the only currently known MOF using these kind of nodes and was first reported by Navarro et al. Its catalytic performance has already been studied on the olefin hydrogenation of 1-octene and cyclodecene, the oxidation of alcohols, for the Suzuki-Miyaura cross-coupling reaction of arenediazonium tetrafluoroborate salts with arylboronic acids and for phenylacetylene semi-hydrogenation in water. The reported data show promising results especially for the selective catalytic hydrogenation but also the possibility of the reduction of Pd 2+ to Pd 0 under reductive conditions, resulting in the collapse of the structure. In this work, we explore the outstanding performance of the [Pd(2-pymo)2]n MOF for the selective catalytic hydrogenation of acetylene under industrially relevant reaction conditions. The advantages of defined isolated palladium sites in a metal-organic-framework structure are proven. Additionally, we demonstrate how the stability and long-term catalytic performance can be significantly increased by supporting of the MOF particles and enabling a synergetic effect comparable to strong metal support interactions.