precisely, the smaller [𝑆 ] respect to the second Michaelis constant 𝐾 , the larger is the decrease of the maximum current compared to that predicted for a canonical MM mechanism involving the same first step when 𝑄 ≡ 𝑃. However, any Lineweaver-Burk plots established for sufficiently large 𝐾 /[𝑆] values will have different significance than they would for a true MM mechanism. This is fully evident upon examining the equation ( ) of the linear asymptote of Eq.( ) that is reached at large 𝐾 /[𝑆] values (compare Eq.( )