In this regard, Multi-Component Reactions (MCRs) have demonstrated their potential for the formation of chiral compounds with high molecular diversity and complexity. Through the formation of a metal carbene, diazo compounds can react as nucleophiles and electrophiles at the same carbon center, allowing the formation of multiple chemical bonds in a single step. Recently, fluorinated diazo compounds, such as 2,2,2-trifluorodiazoethane (HN2CCF3, 1), have been used in the synthesis of trifluoromethylated compounds. Nevertheless, enantioselective methods have been mostly limited to cyclopropanation. In the case of MCRs, there are only examples of the use of amines as nucleophiles to access aziridines, triazolines or 1,2-diamines. To the best of our knowledge, the use of alcohols as nucleophiles in asymmetric MCRs with fluorinated diazo compounds has never been reported.