This work explores abaucin-derived chemical spaces by designing ondemand-libraries fitting their probable docking-cavities. Abaucin is a recently discovered antibiotic specifically targeting the lipoprotein transport LolCE of Gramnegative A.baumannii. For potential antibiotic study purposes, a new library of ~ 4000 abaucin-children molecules were computationally generated and selected by best fitting to the corresponding abaucin-LolCE docking-cavity.