Hypothesizing that changing the right side of the molecule would impact its potency, we downloaded a library of commercially available amines from ChemSpace and did virtual synthesis using our VIRTUAL CHEMIST workflow on Forecaster. This workflow enables us to prepare virtual combinatorial chemical libraries with the chemical schemes and the libraries of molecules provided to the program. A catalog of commercially available amines and XZ-9 were input into the program and generated the coupled products by peptide coupling. The coupled products were then docked into the active site of PL pro using FORECASTER. KH-6a and KH-6b were chosen to be synthesized based on visual inspection of the docking poses (Scheme 6). Scheme 6. a) DCC, DCM, rt, 16 h, 66%; b) K2CO3, MeOH, rt, 1 h, 91%; c) EDC•HCl, DMAP, DCM, rt, 20 h, 77%; d) LiI, pyridine, 160 °C, 30 min, microwave, then EDC•HCl, DMAP, rt, 24 h, KH-6a) 7%; KH-6b) 7%.