Besides the scientific design of formulation composition, the development of solid protein formulations requires robust and efficient drying processes. In the past decades, traditional lyophilization technology has been widely utilized. It is known that lyophilization technology is a batch process and timeconsuming with very low energy usage efficiency. In recent years, advanced alternative drying methods, e.g., spray drying and lyosphere, are gaining increasing attention in addition to complimentary techniques like microwave drying to improve drying cycle times. However, biomolecules can still undergo assorted stress, e.g., temperature, shear stress, and interfacial stress, during drying steps which can induce unfolding, aggregation, and loss of functionality. For example, high temperature in spray drying can induce protein denaturation and rapid removal of water can introduce air-liquid interfacial stress and subsequently result in aggregation. Understanding the impact of formulation process conditions on the protein's structural and dynamic stability can aid in manufacturing solid protein formulation with robust storage stability.