CSIC reactions are also employed for the construction of fused aromatic systems. For instance, N-arylation with 2chloronicotinonitrile 101 of mesylated methylamine was utilized to obtain sulfonamide 102. It is worth noting that upon the first step, a partial conversion of 102 into the cyclic product 103 of the CSIC reaction occurs. However, a complete conversion of 102 to 103 was achieved using NaH in THF, resulting in a 60% yield. Further acid hydrolysis of the enamine fragment led to the formation of ketosultam 104 (Scheme 13). Scheme 13. Synthesis of fused pyridosultams 1.66 and 1.67