Notably, even after carefully considering the various aspects of target data and fitting algorithms, one should be aware that fitting may not lead to a unique solution and that overfitting, e.g., by ignoring the inherent data uncertainty, targeting only one type of data, or severely overweighting one measurable, may lead to an incorrect ensemble being produced by the gray-box force field. Nevertheless, a force field that reproduces the high-quality experimental data with a robust connection to simulations has a higher likelihood of representing the correct, underlying physical behaviour.