Pose-scoring functions are well-known to provide limited accuracy due to their neglect of many important (but expensive-to calculate) terms. Docking results therefore usually include many hits of dubious performance and cannot be used "as is". Their results are, however, enriched in potential binders, which considerably speeds the detection (through more expensive methods) of promising ligands. The unbinding events that we observed in the molecular dynamics simulations of two of the three highest-scoring candidates are therefore not surprising. Those unproductive simulations suggested, however, that the iodine-substituted oxoindol group might be used to improve the binding of potential drugs targeting PLPro.