Acetophenone is an organic compound that is used in the synthesis of many organic pharmaceuticals, and it is also a precursor for many resins and fragrances. A condensation of acetophenone and aldehyde gives a very important class of organic compounds known as chalcones. Chalcones offer a wide range of medicinal properties, including antiplasmodial activity . Acetophenones form part of the most active fragment of the chalcones and other classes of organic compounds. Modifications on the acetophenone ring improve its activity. Some acetophenones used in the synthesis of chalcones have been modified through the addition of electron-withdrawing or donating substituents such as methoxy, hydroxy, chlorine, and alkyl to give different pharmacological activities. The presence of electrondonating groups on the acetophenone ring, according to Li et al. is advantageous to antimalarial activity. Structure-activity relationship (SAR) evaluation shows that the size and hydrophobicity of the attached substituents on the acetophenone are critical parameters regulating the activity of the ring .