Overall, we are convinced that an open communication (Open access / Open data / Open source ) and IP-free outcomes are of greatest importance, as previously advocated by Aled Edwards 101 and the Covid Moonshot . For example, leads from the Covid Moonshot have recently been advanced to find a broad-spectrum nM inhibitor for SARS-CoV-2 , but those authors opted to protect its use by patent applications (cf. 'Notes' section in ref. ). This will ultimately restrict access to therapies for low-and middle-income countries for decades to come. If we are to be more prepared for future pandemics, the greater the openness the better. More practically, we believe large and chemical diverse government-managed compound libraries should be readily available (such as the "Chimiothèque Nationale" 103 containing 80000 compounds and 15000 natural extracts), EU-OPENSCREEN´s unique compound collections containing over 96000 compounds 104 , NCATS library containing over 10000 compounds including about 3000 drugs 105 , to provide the first experimental activity/structural data, immediately and publicly shared, needed for computational researchers as a starting point.