The main differences in the second global optimization method studied in this work is the criterion for making a new decision and the algorithm for perturbing the previous decision. In this method, the new solution obtained after perturbation and optimization is accepted if the energy estimate is strictly better than the previous one. Also, in the algorithm of perturbation of the configuration all elements (torsional angles, global rotation and tranfser) are changed at once. From now on, we will refer to this algorithm as Method 2, algorithm from as Method 1.