After vectorizing the SMILES of all parent and progeny drugs using Mol2Vec and ESR representations discussed above, we first visualized their distributions in multidimensional spaces constructed using t-distributed Stochastic Neighbor Embedding (t-SNE) implemented in Sci-Kit learn module . Two-dimensional projections of these spaces are shown in Figure and evidence different distributions, though sharing some similarities. For example, area densely occupied by compounds currently tested for COVID-19 (red circles) is also rich in drugs in Phase 3 clinical trials (orange circles). Another observation is that analogs of Emtricabine, Azvudine and Ribavirin antivirals tend to form similar clusters in both projections.