As the binding mode of dabrafenib in BRAF-V600E is experimentally known (PDB-ID: 4XV2), we take advantage of this complex for further calculations and use it as template for docking the dabrafenib metabolites. Unfortunately the experimental structure is not complete and for chain A the missing loop residues (432-448, 488, 489, 597-614, 627-631, 721-723) had to be modelled.