The software HSPiP also provides a method to semi-empirically determine the HSPs values by dissolving the compound in a wide range of different solvents. Therefore, the solubility profiles of homo-/triblock copolymers were checked in 31 different solvents at concentration of 20 g/L by shaking at 25°C for 24 hours. The results were recorded as binary score of 0 and 1, corresponding to insoluble and soluble, respectively. These results were further incorporated into HSPiP software and experimental HSPs values were obtained.