The ability to obtain high yield of BINOL is interesting in its own right, as the compound is a Class III atropisomer with high barrier to rotation. Further, it is a commercially important material with application as a resolution agent for API, a chiral ligand, and a feedstock for production of many other chiral ligands and acids. Attention turned to development of a DKR for the highly elaborated API, MRTX1719 (Figure ). Operating in batch mode, a yield of 37% could be obtained in a single crystallization. A second crystallization could be run increasing the total yield to 60%, after recovering the mother liquors and heating at reflux for 24-48 hr to regenerate the desired epimer. Further crystallizations were not run because impurities were formed in the epimerization, and the manual operation was tedious and producing less material at each turnover.