For a detailed explanation of how QM job run time is defined and determined, please refer to the Methods section. Note on model chemistry notation: Throughout this work, composite methods are labeled as "Single-Point Level//Geometry and Frequency Level," indicating that ∆H • f values are computed at the single-point energy level on geometries and frequencies obtained at the specified level of theory (e.g., DLPNO-CCSD(T)-F12d/cc-pVTZ-F12//ωB97X-D/def2-TZVPD). For single-step DFT methods, because the same level is used for geometry optimization, frequency calculation and single-point energies, we simply use the method name itself (e.g., ωB97X-D/def2-TZVPD). Each level of theory is denoted in a conventional "functional/basis" format, unless an alternative name (e.g., GFN2-xTB, G4) applies. Additionally, unless otherwise noted, all model chemistries include atom-energy and bond-additivity corrections, and thus "AEC" and "BAC" are omitted in the shorthand QM method name for brevity.