Additionally, the support assists pure Pt clusters in reducing the CO binding strength to values comparable to equimolar PtGe clusters in gas-phase, which can be reduced further by Ge alloying. Within the 2D materials considered in this work, we show that this effect can be exploited to the point that the interaction with CO is not even favorable, as it is found in the case of Pt5Ge5/germanene, therefore completely inhibiting the CO poisoning on the catalyst.