Chemical space visualization occupied by compounds in DS, based on ECFP4 fingerprints (being this chosen because have a better resolution than others), show agonist and antagonist molecules to be close in space, due to that type of compounds are similar between them, according to the results previously shown . In the lower right corner of the plot, molecules with five-membered rings are shown, usually lactonic and thiolactone rings. In this region of the chemical space, can be found compounds of LasR and RhlR DS, agonist and antagonist of LasR are closer to each other than molecules of RhlR since the spatial location is given by the structure. In the upper right corner of Figure , molecules with triphenyl scaffold are found, characteristic of LasR DS.