A diverse set of water cluster-probe configurations was obtained from the process described in the previous section. Figure shows all benchmark binding energies (BE) obtained for the dimethyl ether molecule and all of the different water clusters. Due to its relatively simple structure, the discussion will be focused on this probe. The BE data cover an energy range from -0.19 kcal/mol to -8.42 kcal/mol. A careful inspection of the geometries of the complexes associated with Figure led us to identify six different classifications of noncovalent interactions, summarized and defined in Figure . This classification can be extended to the rest of the complexes formed with all probes. Analogous graphs for the remainder of the organic molecules can be found in the SI. They all display a similar pattern and the same type of noncovalent interactions. The only exception is dimethylamine, which presents an additional interaction when the probe donates an HB (N-H) to an oxygen atom in a water cluster; this interaction is usually found to contribute ca. -2 kcal/mol to -3 kcal/mol to the BE.