The Results section shows that our method estimates the kinetics of the systems of interest, i.e., alanine dipeptide and chignolin, more quickly and more accurately than the WE method alone. Long-scale unbiased MD simulations or brute force methods are often used as a reference for evaluating the performances of new methods on model systems. Five independent brute force simulations each of 2 µs for alanine dipeptide and 4 µs for chignolin were performed to obtain the reference values of rate constants over aggregate simulation time. DeepWEST performs equally well and often surpasses the brute force and the hybrid GAMD-WE approach with the advantage of being computationally inexpensive and easy to implement while adding no statistical bias to the system.