In conclusion, we have synthesized two phenacyl bis-azide crosslinkers, which have been incorporated in dextran-based hydrogels to enable photosensitivity in the Cerenkov emission window. Crosslinker C1 photodegrades upon 254 nm light irradiation resulting in the complete dissolution of C1 crosslinked dextran hydrogels releasing loaded doxorubicin. However, the absorption spectrum of C1 has a too small overlap with the CL spectrum, and UV-A irradiation leads to drug disintegration. A redesign led to extended crosslinker C2. C2 crosslinked dextran hydrogels were loaded with BSA protein or human IgG antibody which was released upon 375 nm light irradiation. The release efficiency for BSA was 45% after 24 hours irradiation, and 96% for the IgG antibody after 9 hours of 375 nm light irradiation.