To this end high and medium quality activity data was collected for human Aurora kinase A (AURKA) (UniProt accession O14965) and human Aurora kinase B (AURKB) (UniProt accession Q96GD4) from the Papyrus dataset. The dataset for AURKA consisted of 1 232 bioactivity data points with pChEMBL values ranging from 3.4 to 11.0. The dataset for AURKB consisted of 1 131 bioactivity data points with pChEMBL values ranging from 4.1 to 11.0. For the selectivity window model, an additional dataset was created with compounds with experimental Ki values for both of the targets . This dataset consisted of 849 relative affinity values ranging from -1.6 (indicating selectivity towards AURKA) to 3.0 (indicating selectivity towards AURKB).