Here, an important question may be raised: can the model exhibit robust transferability in a new system, and do the structural weight parameters learned from PDBbind remain effective? To answer this question, we first assessed the model on a dataset compiled by Mohammad et al., which contains 16 primary SARS-CoV-2 inhibitors . These inhibitors exhibit structural diversity but share similar core scaffolds, with binding free energies (BFEs) ranging over 5 kcal/mol. Notably, some inhibitors differ structurally by just a halogen atom, posing a challenge to the model's discriminative capacity.