These results demonstrate that the attractive interactions in the touch and lock modes can be independently controlled by altering the ligand bundle order and solvent size. Finally, we tested the combined effects of both modulation methods. We used a DB fragment to reduce the order of the dNR ligand bundles (i.e., mDB-dNR) to weaken the attraction in the touch mode and employed tol as the solvent to weaken the attraction in the lock mode. Figure compares the PMFs of NC pairs for dNR in hex, mDB-dNR in hex, and mDB-dNR in tol.