For the nSPS, the distribution of both, the Enamine-PNPs and the selected CPA subset are shifted to higher complexity scores, relative to the full Enamine library (Enamine-All). This could be hinting at a general higher molecular complexity of the PNP structures (medians of nSPS values: Enamine-All:14.5, Enamine-PNP: 16.3, Enamine-PNP CPA: 17.6).