We also benchmarked the recombinant sets with the help of the MOSES platform. This tool is designed to support the evaluation of generative models for molecular structures. It computes an array of metrics and compares the generated output to the characteristics of the data used to train the model . Whenever possible 30000 molecules were sampled. As expected, all molecules passed the validity test based on valency and bond consistency. Checks for uniqueness were skipped since the cut-and-join algorithm is implemented in a way to not save duplicates. The novelty check, comparing canonicalized SMILES, confirmed that there is little to no overlap between the input database and the recombination products. The full table of MOSES metrics for the different recombinants can be found in Additional file 4.