A curative method for the evaluation of parasitemia established by Ryley and Peters was adopted . The curative evaluation of parasitemia was evaluated using percentage chemo-suppression. The method was used to evaluate the curative activity of the compounds against established malaria infection. At the highest dose of 100 mg/Kg, compounds (I) and (II) significantly (p < 0.05) reduced parasitemia levels producing percentage chemo-suppression of 69.75% and 72.16% respectively as indicated in table . This model was chosen for the study because it evaluates the possible prodrug effect of the compounds. Compounds are considered active when the reduction in parasitemia is ≥ 30%. Consequently, based on these criteria, compounds (I) and (II) can be presumed as having good antimalarial activity. However, the standard drug chloroquine showed better antimalarial activity with 95% inhibition of the parasitemia.