Metal-organic frameworks (MOFs) have generated much interest for decades owing to inherent large surface areas, uniform but tunable cavities and modifiable structure, which make them be promising catalysts. NH 2 -MIL-125(Ti) was a kind of good photocatalyst which have already enabled good photocatalytic applications under visiblelight. Recently there have been some reports that demonstrated the applications of NH 2 -MIL-125(Ti) for organic transformations. Although NH 2 -MIL-125(Ti) and its modified photocatalytic material have been widely employed to achieve the selective catalytic oxidation of alcohols or amines to aldehydes or imines, few reports on the transformation of alcohols directly to carboxylic acids in visible irritation can be found elsewhere. In this case, the MOF catalyst remains a lot of potential in the synthesis of carboxylic acids but there exists a fundamental challenge.