Correlation-based statistics methods provide a rough comparison of methods. Figure shows R 2 and Kendall's Tau values calculated for each method, sorted from high to low performance. It is not possible to truly rank these methods based on correlation due to the high uncertainty of each correlation statistic. Over half of the methods have R 2 and Kendall's Tau values equal to or greater than 0.5 and can be considered as the better half, however individual performance is largely indistinguishable from one another. For R 2 , two methods (EC_RISM, REF00_Chemaxon_Chemicalize), seem to have a greater ranking ability than the other methods.