The model accurately predicted the mono-atropoisomer with the UL1 ligand with an error of 0.08 kcal mol -1 only. To further test this hypothesis, the enantioselectivity for the methyl-substituted quinolinamide was predicted with the same UL1 ligand. A significant increase in enantioselectivity was predicted by the model which later was found in agreement with the experiments, showcasing the successful extrapolation of the developed model from mono to dual atroposelectivity (Scheme 4C).