Second, we apply the method alongside MSMD simulations to enhance the binding of organic probe molecules in occluded binding pockets. We study two systems with occluded binding pockets, T4-lysozyme (T4L99A) and major urinary protein 1 (MUP1). Simulation studies of the former show that the binding of benzene requires multi-microsecond long simulations which are unfeasible in a real world setting. Using GCNCMC, we can overcome these time scale limitations by inserting molecules directly into the binding site; we can do this in a prospective manner by assuming that benzene could bind anywhere on the protein and setting the region in which GCNCMC moves can occur accordingly. We compare the sampling between our GCNCMC-enhanced MSMD simulations to classical MSMD simulations.