Palladate 2 was subsequently tested as a catalyst substitute across a selection of cross-coupling methods (Scheme 2). Parallel reactions were conducted using either the literature catalyst or an admixture of 2 plus the relevant ligand and yields were determined by 1 H or F NMR spectroscopy using an internal standard. The room temperature Buchwald-Hartwig amination of p-chlorotoluene and a dibutylamine using Ruphos + 2 formed product 5a in high yield (99%) as compared to the reference case (94%) using the [Pd(α-Me-napththyl)µ-Br]2 precatalyst developed by Gooßen. Amination of an arylthianthrenium salt with morpholine was similarly effective using RuPhos and 2 (88%) as a substitute for Pd2dba3 (86%) to form product 5b. A weak base amination method also effectively formed 5c from the drug amoxapine in 55% isolated 30 yield using PAd3 and 2 versus the analogous reaction using isolated OAC 1 (63%). Examples of C-O and C-C cross-coupling reactions further highlight the versatility of the approach. Coupling of a chloroquinoline electrophile with cyclohexanol generated 5d in 59% yield using Mor-DalPhos and 2 as opposed to the use of [Pd(cinnamyl)µ-Cl]2 (54%). 31 A base-sensitive Suzuki-Miyaura coupling using 2,4,6-trifluorophenylboronic acid generated product 5f in 97% yield using P(t-Bu)3 and 2 as a substitute for the isolated OAC (P t Bu3)Pd(4-C6H4CF3)Br (99%). Lastly, aqueous micellar cyanation of the Merck informer compound X8 using Zn(CN)2 and admixture of Xantphos and 2 was equally effective as (Xantphos)Pd-G3 (81%). A few additional examples can also be found in the ESI (Tables and), such as amination using IPr as ligand, or cyanation of Merck informer compound X6.