Despite the significant interest in interfacial molecular orientation studies, there have been limited efforts to investigate the advantage of using waveguide constructs with incorporated plasmonic components to conduct polarized SERS. Waveguides are mediums that guide and propagate electromagnetic waves and can support both transverse electronic (TE) and transverse magnetic (TM) polarizations. The inclusion of plasmonic components on the waveguide increases the interfacial mean square electric field relative to the incident field, and the resulting plasmonic excitation can be controlled in both position and polarization . This design of plasmonic waveguide sensors is compatible with the design of current Raman-based planar biosensor chips.