The SAMPL8 host-guest challenge was organized similar to SAMPL7, allowing participants to submit their "top" predictions as a ranked submission for any or all of the datasets (CB8 and GDCC), but a submission for either dataset was required to include all guests. Only ranked submissions were considered for the main analysis of the challenge. Additional submissions were allowed, but needed to be denoted as non-ranked. Non-ranked submissions gave us an opportunity for benchmarking and provided additional methods for cross comparison, while still allowing each participant only one opportunity to formally compete in the challenge. All participants formally submitted blind predictions prior to the challenge deadline. In addition, two members of our team (MA and JS) conducted blind reference calculations which were submitted informally in the non-ranked category.