With our mixing elements nominated, the reactor systems illustrated in Figure were assembled for further evaluation. For convenience, we opted for a variant of the HTM-ST chicane mixer, the HTM-ST-3-1, which has longer static mixing paths with an additional input that could be used for an electrophile input in place of the 250 μm Tee piece utilised for the reactor described in Figure . As a means to further reduce internal reactor volume, pre-cooling loops were shortened to 10 s each, a decision that was rationalised through previous work on similar substrates and the data in Table , which show a conservation in reaction profile across cooling times. As an aside, a pre-cooling time of 10 s delivered satisfactory performance at a bath temperature of -55 °C in the test reactions used (see supplementary information). These data, coupled with those in Table led us to assemble the reactors depicted in Figure . When compared with other reactor systems reported in the literature (Table ), we note that both the chip and Tee-based reactors in We then determined the lowest volume of aryl halide stock solution necessary for a reliable lithiationtrapping synthesis in both reactors shown in Figure by determining the yields (via HPLC) of two model reactions as a function of the aryl halide injection volume. In designing the experiment, we opted for aryl halide-electrophile combinations that formed a homogeneous solution upon workup. This allowed analytical samples to be afforded by simple dilution and minimised the yield losses associated with a more involved workup.