In summary, I present the synthesis of RDRP of beta-alanine via Zn-mediated RDRP for dye encapsulation and for model proof of concept of DOX-release. The benefits of group-free chemistry, handling, recovery, and reusability in addition to the ease of catalyst synthesis could make this simple synthesis protocol highly applicable for the synthesis of biohybrids in a number of exciting fields, such as material science and biomedical science. The stimuli responsive biohybrid that was synthesized could be helpful in the development of multi-stimuli responsive actuators for use in biomedical applications.