ASDs with different RTV to PVPVA ra os (at 20 % w/w intervals from 0 to 100 % drug loading) were prepared using solvent evapora on. Mixtures of RTV and PVPVA (total 1 g) were prepared at different RTV to PVPVA weight ra os (0:100, 20:80, 40:60, 60:40, 80:20 and 100:0) were prepared and dissolved in 5 mL of methanol (20 % w/v solid content) in 14 mL glass vials. The solu ons were mixed using a vortex mixer and an ultrasonic bath sonicator (5 minutes) to ensure complete dissolu on. The solu ons were then cast onto a glass or aluminum substrate, depending on the subsequent analysis technique. The cas ng was performed in low humidity environment (20% rela ve humidity or less) to avoid immediate phase separa on in the films. For X-ray powder diffrac on (XRPD), polarizing light microscopy (PLM), and spontaneous Raman spectroscopy, 50 µl of each mixture was cast onto 18x18 mm square cover glasses (No. 1, EUKITT®, ORSAtec). For modulated temperature differen al scanning calorimetry (mDSC), the solu ons were cast directly into Tzero aluminum pans (TA Instruments, Switzerland). For SRS microscopy, ⌀35 mm glass bo om dishes with ⌀14 mm microwell and No. 1.5 cover glass (MatTek, USA) were used. A small droplet of the solu on was cast onto the center of the microwell. All samples were then immediately placed in a vacuum oven at room temperature for approximately 44 hours for residual solvent removal and to prevent water sorp on. Subsequently, the samples were stored in a dessicator over silica gel at room temperature un l measurement.