A rationale for the effect of confinement on the phase behaviour of metastable liquids is provided by developing a model for crystal nucleation in confined volumes analogous to the modified liquid droplet (MLD) model developed by Reguera et al. to describe depletion effects on the thermodynamics of nucleation of liquid droplets Consider a two-component supersaturated solution, 𝓁. The chemical potential of solute 𝑖 in solution can be written as,