The majority of applications lay in the food and consumer products space (n=19 studies), followed by air (n=15), soil/sediment (n=13), dust and human samples (each, n=10) and then water (n=9). Fundamentally therefore, it seems that researchers have assumed that at exposome relevant concentrations, a large component of chemicals can be separated via a chromatographic approach and be ionized/fragmented via HRMS technology. It should be noted that slight deviation from the optimal experimental conditions may have extreme impact on the measurable subspace explored by the used method. 12,36,37,83,84 There are several such examples where more generic methods fail to cover highly relevant chemicals in the exposome chemical space (e.g. PFOA or glyphosate).