We have demonstrated that metal coordination chemistry is able to assemble glycoconjugate ligands in such a way as to enhance antiadhesive effects from binding to pathogens' carbohydrate-binding proteins, in the case of P. aeruginosa and C. albicans (both WHO Critical Priority pathogens). Galactoside 1Gal has micromolar binding affinity for PA's lectin LecA, but while the ligand alone doesn't demonstrate biofilm inhibition for this bacterium in vitro, the Eu(III) complexes do so at subinhibitory concentrations (up to 47% for the 1:1 complex). DFT modelling suggested that this ligand shared structural properties with previously-reported anti-CA agents, and indeed 1Gal and its complexes with Ni(II), Zn(II) and Eu(III) also display antiadhesive effects on the fungus' interactions with human BECs in vitro, with the most effective agent again being the 1:3 Eu(III) complex. This lead complex inhibits or outcompetes >60% of yeast adhesion, and demonstrates clumping of the yeast cells. These results indicate that while carbohydrate epitopes target pathogens' carbohydrate-binding proteins, this may not directly translate into antiadhesive effects -this is pathogen specific, and activity may be obtained or modulated through choice of coordinated metal ions. Eu(III) complexes, in particular, show promise from this study and we are seeking to optimise these structure to allow for future use of these luminescent compounds for imaging, and to probe whether this activity is shared across the range of lanthanide(III) complexes, or if Eu(III) plays a unique role in the mode of action of these complexes. These promising results open up opportunities to develop further antiadhesive metal complexes, with variation in topology, ligand design and metal-centred activity, such as redox activity.