Representative graph of n = 2 biologically independent experiments, each performed in triplicates. For mean ± SD see Table . and HDAC8 compared to the vehicle control group (Figure ). In contrast, the tubastatin A-based degrader AP4 caused no relevant HDAC1, HDAC4, or HDAC7 degradation but significant HDAC8 degradation, while AP1 induced no off-target degradation at all (Figure ).