Tables 3-5 summarize the number of unique and common fragments and "Fragments RO3" for the CRAFT, LANaPDB, and COCONUT libraries, as compared to the reference fragments collections. Table indicated that CRAFT has a high percentage of unique fragments (94.76% -99.75%) and "Fragments RO3" (81.82% -99.43%) as compared to COCONUT, LANaPDB, ChemDiv, Enamine, Maybridge, and Life Chemicals. COCONUT (63, 5.24%) was the database with the highest percentage of fragments in common with CRAFT. Similarly, CRAFT and COCONUT have 32 (18.18%) "Fragments RO3" in common. In contrast, LANaPDB shared the fewest structures with CRAFT. CRAFT has a high percentage of 99.75% (1,199) fragments and 99.43% (175) "Fragments RO3" not present in LANaPDB.