Second, in TR-AdResS, the TR region does not interact at all with the AT region, i.e. it provides no solvation contribution to a solute located in this region. This is not the case for AdSoS, where the scaled solvent in the SG and CG regions provide (by construction of the scaling) appropriate solvation contributions to such a solute (see Fig. The original article provided the theory along with an initial application of AdSoS considering a pure monoatomic solvent (no solute) in a slab geometry. The goal of this article is to extend the AdSoS scheme to more practically relevant situations, involving: (i) a molecular dipolar solvent (e.g. water); (ii) a radial geometry (i.e. spherical rather planar layers); and (iii) the actual inclusion of a solute (e.g. solute water molecule, dipeptide, ion, or ion pair).