Scale-up experiments were conducted to demonstrate the practicality of this phosphonylation protocol. With lower loading of the photocatalyst (1 mol%), -aminophosphonates (3, 68, 16) were obtained in excellent yields on gram scales (Scheme 3A) within the same timeframe (12 h). The benzoyl group (Bz) could be easily removed by hydrolysis in aqueous hydrochloric acid, along with the hydrolysis of the phosphonate, affording aminophosphonic acid 69 in quantitative yields. Additionally, the phosphonate could be transformed into phosphonamide 70 by a three-step one-pot process (Scheme 3B).