To help quantify this, the observed reaction rate has been plotted against the lengthscale separation of the intermolecular and intramolecular beads in each system (Fig. ). The PEG-M1 and R4 mapping show breaking of all bonds within the timescale of the simulations, whereas no bonds are broken for the R2 and R3 mappings. The corresponding lengthscale separation (i.e. the ratio of the minimum separation at which intermolecular beads are observed, r inter , and the maximum separation at which bonded beads are observed, r intra , in the atomistic simulations and averaged over all bead types) shrinks as the CG resolution decreases, with the ratio < 1 indicating that the intramolecular and intermolecular beads can no longer be distinguished by the model. This lengthscale overlap can also be seen in the RDFs for intermolecular beads and bonded beads (Fig. ). PEG-M1 and R4 are more representative of commonly used coarse mappings of 3-5 heavy The lengthscale separation is given by the ratio of minimum separation at which intermolecular beads can be found (r inter ) and the maximum separation at which bonded beads can be found (r intra ). atoms per bead, but these coarser beads have overlapping intermolecular and intramolecular lengthscales and hence, exhibit unphysical behavior using the ML-only framework. The TL models correct this behavior because they directly incorporate bonding information via the bending, stretching and torsional potentials. Thus, transfer learning molecular information improves the pure ML models in low resolution CG situations where intramolecular and intermolecular lengthscale overlaps are severe.