Finally, Table demonstrates that similar to the base Sage FF, the final relaxed geometries using the Sage+BespokeFit parametrization remain close to the QC relaxed structures after full optimization with all restraints relaxed (with maximum RMSDs around 0.6-0.7 Å). The relaxed MM coordinates are also affected by the other valence and non-bonded terms in the force field, and so again perfect agreement with QM is not expected.