The biocompatibility and biosafety of DIPT-ICF NPs were evaluated. The cytotoxicity of the DIPT-ICF NPs on human cancer cell Hela and human fibroblast cell 3T3 was first assessed through cell counting kit-8 (CCK-8). As shown in Fig. , even though the concentration was increased to 500 μg/mL, the cell viability was not notably affected after 24 h incubation. Additionally, the toxicity of the DIPT-ICF NPs was evaluated through a histological investigation of organs in vivo.