We started from the structure of the α subunit of Na v 1.7 reported by Shen et al. (PDB ID: 6J8I). This is an inactivated state structure with the mutation Glu406Lys and the following missing residues: residues 1 to 113 (N-terminal), residues 418 to 725 (DI-DII linker), residues 973 to 1174 (DII-DIII linker), residues 1769 to 1988 (C-terminal) as well as residues 826 to 830 (VSDII). We added residues 826 to 830 using the SWISS-MODEL webserver. No significant conformational differences were found between the remodeled structure and the original structure (see Supporting Information). We did not add the missing linkers between domains because their addition led to incorrect structures due to both the length of the missing section and their lack of secondary structure.