Our method has several novel features and clear advantages over existing CSP methods and protocols for predicting molecular crystal polymorphs. First, our method uses a novel algorithm that systematically and efficiently explores the vast space of possible crystal packing parameters, overcoming the exponential scaling challenge of multi-parameter sampling for Monte-Carlo or other stochastic methods. Second, our method effectively balances the accuracy and throughput for candidate structures ranking by using a hierarchical approach that incorporates different levels of accuracy and computational cost, from empirical force fields to DFT calculations. Third, our method leverages the power of a pretrained, transferable MLFF which predicts the relative stability of different polymorphs with sufficient accuracy to require only a practical number of DFT calculations. The pretrained MLFF can be further customized on a per molecule basis with molecule specific DFT calculations to further improve the reliability and further decrease the number of expensive periodic DFT calculations. Considering the well documented high accuracy requirements of successful crystal structure ranking, neither of the current MLFF models used in this work are of sufficient accuracy to completely remove the need for periodic DFT refinement.