Next, we worked with various GÌC complexes described above (G = 5-12) with the goal of crystallizing C as an inclusion complex, where the presence of the guest would sustain the cage in the C form. These trials, too, proved unsuccessful: C filled with hydrophobic guests typically afforded non-diffracting thin films upon water evaporation, whereas diffusing acetone induced guest release, which facilitated C→T isomerization and consequently crystallization of T (and/or free guest). Evaporation of water from aqueous solutions of 11ÌC and 12ÌC or introducing acetone to these solutions resulted in thin films. Given the structural similarity of C and the Fujita cage (Figure ), we also attempted to cocrystallize C and its inclusion complexes with the Fujita cage, hypothesizing that the readily-crystallizing Fujita cage might promote the formation of crystalline C; these attempts also failed. After numerous attempts, single crystals of C suitable for X-ray diffraction were obtained by very slow (over two months) water evaporation from an aqueous solution of 10ÌC. As expected, 10's sp 3 - hybridized carbon atom resides in the center of C's cavity, with the four hydroxyl groups protruding through the cage windows. Interestingly, whereas the cage retained its overall Td symmetry, it underwent a local desymmetrization upon crystallizing (Figure ). Specifically, one of its TImB "walls" changed the rotation direction, and the resulting cage consisted of three panels rotating in the counter-clockwise direction and one panel rotating in the clockwise direction (see the cartoon in Figure ). No other form of the cage was found in the single crystal of 10ÌC. We speculate that while less energetically favorable, this unexpected conformer of cage C optimizes packing in the crystalline state.