In this section, we focus on a handful of reactions that are often used to exemplify the rules of thumb and test the computational calculations (Table ). Most of the experimental data has been obtained by Cabri and co-worker 17 for the reactions shown in Figure . Our methodology generally predicts the β selectivity for the neutral reaction pathway mechanism, except when the alkene substituent is 2-pyrrolidone where the energy difference between the two intermediates is less than 3 kcal/mol ≈ 12.6 kJ/mol. Thus, for the reasons discussed in the previous subsection, we generally are not able to predict the alkene substituents that give rise to a mixture of regioisomers under neutral conditions.