Altogether eleven previously reported binding affinity models were selected for comparison, we make sure that the training set and division method used for these models are the same with ours. Here, the protein-ligand complexes in the refined set were split with a ratio of 9:1 according to the same seed of the SIGN model for training and validation. prediction tasks, QM7, QM8 and QM9 for Quantum Mechanical properties prediction tasks. Among these tasks, 3D ligand conformation could be chosen as the input data for the QM7, QM8 and QM9 datasets, while 2D molecular graph is the input for other seven datasets.