As accurate prediction of the correct bindingposes during virtual screening is essential for the reliability of the screening process. Our protocol was applied to a set of five different PL-pro inhibitors with a range of binding affinities; as shown in table (1). There are the ligands from holo-structures of PDB IDs: 7JIV, 7JRN, 7RZC, 7SDR, and 7TZJ, targeting the catalytic binding site of Pl-pro. The ligands were screened