Despite the utilization of diverse delivery methods for nucleic acid drugs in cancer therapy , there remains significant potential for exploring DNA nanotechnology in this context. We envision that leveraging the adaptability of both the drug and its carrier could facilitate the development of bio-nanorobots endowed with dynamic capabilities and computational potency, enabling precise content delivery and release. Before exploring our prospects for a bio-nanorobot transporting oligo drugs, we conduct a review of advancements in DNA dynamic nanodevices and DNA computation studies.