Dietary supplements, such as vitamins, minerals, amino acids, essential fatty acids, flavonoids, plants and herbs, and accessory food ingredients, are considered valuable and safe materials for prevention and treatment of chronic and acute diseases. Interest in the therapeutic capacity of vitamin supplements, specifically vitamin D, for stimulating human longevity and reducing risk of aging-related pathologies is currently a hot topic in clinical studies. 501 Indeed, it has been reported that vitamin D and its metabolites can delay ageassociated diseases by lowering oxidative stress, strengthening innate immunity, preventing DNA damage and supporting DNA repair pathways, controlling mitochondrial and glucose metabolism, defeating cellular senescence, enhancing telomerase activity. These research findings imply that vitamin D consumption exhibits anti-aging properties. Recent systematic review have also reported that vitamin D intake notably lowers the risk of acute respiratory infections. Other vitamins such as B vitamins, K vitamins, and others, have been examined as dietary supplements that assist healthy aging. 500 Thus, vitamin B12, in combinations with bacopa, lycopene, and astaxanthin successfully alleviated cognitive decay associated with brain aging. Improving vitamin interventions by combining them with other health-supporting supplements might result in successful clinical utilization.