The simplicity, robustness and versatility of the recently developed "drug-initiated" / "grafting from" method has made it possible to design polymer prodrugs based on different drugs and with adjustable properties, enabling either nanoparticles/micelles or water-soluble polymer prodrugs to be obtained. The added value of RDRP regarding the "grafting from" approach is the possibility of adjusting drug loading notably by varying the polymer chain length, as well as chain-end functionalization to insert other molecules of interest (e.g., second drug, targeting ligand, fluorescent probe).