To develop and validate the proposed workflow, we first selected a representaVve pore carrier to serve as an iniVal case study. Of the candidate hosts for type II PLs, porous organic cages (POCs) present an example of an ideal molecular moVf for PLs for several reasons: (i) POCs are discrete molecules containing a permanent cavity accessible through windows, and (ii) POCs possess an inherent soluVon processibility and maintain their pore structure upon dissoluVon. Owing to these factors, POCs have formed the basis of a substanVal number of type II PLs to date. However, complicaVng the computaVonal challenges, POCs generally possess fairly low solubiliVes overall. A number of design strategies have therefore been employed to increase their solubility enabling high concentraVon PLs to be realised, with the most popular being the formaVon of staVsVcal 'scrambled' distribuVons of POCs with mixed vertex funcVonality to disrupt the solid-state packing and increase the solubility in a range of size-excluded solvents (Figure ). In addiVon, one parVcular 'scrambled' POC, 3 3 :13 -R (Figure ), has previously been screened in a wide range of solvents using both brute-force manual measurements and simulaVons, as well as highthroughput experimental screening, 9,10 leading to a family of type II PLs by varying the size-excluded solvent (Figure ), and also providing iniVal data for the solubility screening workflow here.