In this paper, we firstly established the detailed procedures for the synthesis of new hemin derivatives aiming at enhancing the properties of hemin in aqueous solution. This was achieved by hemin conjugation to aromatic residues at the terminal -CH2COOH via amide bond formation (1) and-CH=CH2 groups of the porphyrin macrocycle via cross-metathesis reaction (2). Method 1 caused a modulation of the aggregation behaviour of the resulting conjugates and enhanced their resistance to the oxidative degradation. However, method (2) enhanced the aggregation of the resulting conjugate structure.