Figure shows scaffolds frequency in DS on the left side, while the scaffolds structure is shown on the right. The frequency of scaffolds found for DS varies according to DS size (Figure ). Nevertheless, the first five most frequent scaffolds represent around seventy percent of the total, highlighting a variety of types of biological activity in that scaffolds. In LasR scaffolds, it is found that five first have molecules with activity, being the most frequently agonist activity, which is shown in figure ); rings of six members connected between them through a small chain with amide, are the most relevant for this DS.