This highlighted the material potential for clinical applications such as maxillary floor augmentation (Figure ). Noteworthy is that the encapsulation of drugs in the dispersed nano-objects as well as in the hydrogel matrix has enabled a synergistic effect to be achieved, overcoming the challenges of loading two drugs in a single NPs, or the independent fate of two drugs when administered simultaneously but individually. Polymers capable of responding to temperature changes allow the administration of hybrid hydrogels in the form of a liquid formulation that quickly transforms into a semisolid material.