To apply DWBEL co-evolution algorithms, two minimal inputs were required, i) one parent 2D molecule (to randomly generate raw-children) and ii) a targeted protein cavity (to select for best-fitting children). Since there were no previous ligands described, nor target cavities identified for P.falciparum CSP, a previously designed home-library of 3-fold star-like small 2D molecules, with different central atoms, rings and arms (1-6 carbons) was employed for ADV blind-docking (Supplementary Materials / StarLikeLigands.sdf and DWBELhowto.mp4). Parent ligands (L) and their cavities (C) were identified by ADV blind-docking on the selected CSP model to start DWBEL co-evolutions.