The system including dapsone in the ZnI 2 framework (CSD Refcode: CENBUV) is an outlier in the subset. The framework has a calculated ∆E MOF =101.83 kJ/mol, an order of magnitude greater than typical values. In addition, the cell volume contracts by 15.76%, much greater than all other structures. The guest molecule in the experimental structure is clearly defined, with no constraints or restraints applied, and there is no mention of unusual observations relating to the framework by the authors. The framework geometry is unusual: a typical CS structure has a unit cell volume of 15,000-16,000 Å 3 whereas CENBUV has a volume of 12,000 Å 3 . The high framework strain could result from a combination of factors. Dapsone and other molecules with similar N-containing nucleophilic functional groups are known for interacting with and breaking down the CS framework ; the nucleophilic guest attacking the coordination network could therefore cause the framework to become unstable and collapse. In addi-tion, the high occupancy of the guest molecule, combined with the presence of water molecules and n-hexane solvent, could stabilise the high framework strain via strong interactions.