By combining the structural and kinetics insights, we reveal the intrinsic link between the engineered lattice defects and gas enclathration kinetics. The lattice defects enable the pathway for gas migration into the ice lattice and promote the gas hydrate formation. This concept provides a universal pathway to interpret the effects of dopants on gas enclathration. In light of our concept, the underdosed polar molecules (dopants) create defects as open channels for gas diffusion in the host water lattice for promoting gas encapsulation while the overall integrity of the host structure is maintained. In contrast, overdosed dopants cause excessive defects and destroy the gas hydrate structure. That's why methanol with dosages from 10 to 30 wt% is widely used as an inhibitor of gas hydrate formation to avoid the risk of gas hydrate plugging of oil and gas pipelines in the petroleum industry.