To test the accuracy of the MFCC-MBE(2) method for a broader test set of proteins, we considered the SEM5 SH3 domain (PDB-code 3SEM , 58 amino acids, 945 atoms), the immunophilin immunosuppressant complex FKBP-FK506 (PDB code 1FKF , 107 amino acids, 1,662 atoms) and mitochondrial matrix adenylate kinase (PDB-code 2AK3 , 226 amino acids, 3,628 atoms), which were previous used as test cases for quantumchemical fragmentation methods by Grimme and Antony as well as our research group . In addition, we consider the catalytic core domain of FIV integrase (PDBcode 4PA1 , 151 amino acids, 2,378 atoms), which was previously used as a test case by Wang et. al . The small proteins human insulin (PDB code 3I40 , 21 amino acids, 784 atoms) and the C-terminal domain of the ribosomal protein L7/L12 from escherichia coli (PDB code 1CTF , 68 amino acids, 1,005 atoms) were also included in our test set. For comparison, the already discussed ubiquitin (PDB-code 1UBQ , 76 amino ) reduces the error in the total energy significantly. In the cases of 3SEM, 1UBQ, 1FKF, and 4PA1, we were able to reduce the error by a whole order of magnitude.