P53 can induce the phosphorylation of human 2N4R tau, causing neuronal death and other tauopathies. BRCA1 and p53 accumulations have been detected in neurons at the early onset of AD. Although gender and nationality do not seem to be significant factors, certain individuals of Asiatic origin appear to be differentiated. YKL-40 is a new protein under consideration as a brain cell injury biomarker and is increasingly detected in AD individuals between 50 and 70 years old. D-serine levels have been identified and measured in higher levels in the hippocampus and parietal cortex of AD patients and have been implicated as a potential risk factor. Four miRNAs, namely miR-31, miR-93, miR-143, and miR-146a, have been observed to be decreased in the serum of AD patients and are recently characterized as novel biomarkers of AD pathology and vascular dementia. Blood pressure has been proposed as a precursor marker for disease manifestation. High blood pressure can be observed decades before the appearance of disease, when senile plaques, neurofibrillary tangles, and hippocampal atrophy are already present. However, in the later life of an AD patient, low levels of blood pressure occur. The relationship between blood pressure and AD is still unknown, although high blood pressure seems to be a lower risk factor for AD patients.