In our energetic analysis, we identify the smallest energy Z-score from the minimum energy cluster, which we term the energy gap Z-score of the model. If there are degenerate clusters due to the presence of mirror folded states, we exclude the energy gap Z-score between the identified mirror clusters. In the case of figure , cluster 0 and 1 are mirror clusters, as they represent both left-and right-hand forms of a helix. We expect a large energetic Z-score value between the minimum energy clusters and other higher energy clusters. For the example shown in figure , the energy gap Z-score from cluster 0 or cluster 1 to the next lowest energy cluster (cluster 3) is 3.98. Large energy gap Z-scores represent larger energy gaps between identified clusters. Finally, We note the structural and energetic overlap between degenerate clusters 0 and 1 also indicates good sampling of the configuration space of this model.