Employing this equation, this contribution to the redox free energy is equal to 0.01 eV and 0.04 eV for native regions 1 and 2, and 0.07 eV for both defect systems. Compared to the respective absolute value, these contributions are negligible, thus leading to final estimates of 6.82±0.18 eV and 6.94±0.21 eV for two native fragments, and 5.73±0. As shown in the Redox Properties subsection, the reorganization free energy, λ, of the region 1 native and defect systems, is 1.01 ± 0.17 eV and 1.14 ± 0.18 eV respectively, while for region 2, λ amounts to 1.18 ± 0.17 eV for the native system and 1.17 ± 0.18 eV for the 8oxoG-containing system.