In this work, we apply the modified procedure and after each alteration of the training set we repeat the MD selection (see Fig. ). This approach allows for the evaluation of accuracy of the approach in general, rather than the accuracy of one randomly selected MD set. The evaluation of the reproducibility is made for all three IL, but the detailed results are shown only for Bis4MPyC6, unless otherwise specified. The corresponding data set contains 123 compounds of various classes. All conclusions regarding the comparison of the MD selection methods in terms of reproducibility and accuracy are the same for any of the considered IL.