We evaluated our method based on PDBbind splits and metrics of basic GNN methods architectures reported by Li et al. [39]. SR-BIND compares well to all GraphDTA and GNN-based methods (Table ) . This result suggests that, compared to the distance between specific protein and ligand atoms, the molecular topology of the ligand plays a relatively minor role. It must noted that the various GraphDTA Methods do not use geometric information but rely on the more readily available amino acid sequence information for representing the protein.