Exonuclease (IPR013520) is an RNase T/DNA polymerase III exonuclease. Numerous exonuclease proteins, such as the epsilon subunit of DNA polymerase III and RNase T, contain this domain. RNase T, responsible for the terminal turnover of tRNA, removes the terminal AMP residue of uncharged tRNA. DNA polymerase III, a complex multi-chain enzyme responsible for most of the replicative synthesis in bacteria, also exhibits 3' to 5' exonuclease activity.