General ester bond synthesis procedure (21). Solutions (0.2 M) of the respective acid chloride building block in THF and the amine building block in MeCN/DMF (9:1 v/v) were prepared, and 1 ml of each solution was transferred into individual wells in a 96-well plate. The residence time was set to 5 min and the temperature to 55 °C. A 0.75 ml portion of each solution was aspirated into the syringe pumps and diluted to 1 ml total volume with the running solvent (MeCN/THF, 50:50 v/v). After mixing both solutions in the reaction chip, the reaction mixture was pumped through the coil and 2 ml was collected in a 96-well plate.