Herein, we report the successful rROP of DOT with acrylamide (AAm) via RAFT copolymerisation to produce a small library of industrially and biologically relevant water-soluble copolymers where the molar mass and DOT-content can be efficiently tuned. Owing to the integration of labile thioester linkages along the copolymer backbone, these copolymers can be readily degraded under basic, aminolytic, physiological, and commercially available conditions. The copolymers reported here offer exceptionally degradable alternatives to the hydrophilic polymers currently used in the biomedical, water treatment, and agricultural industry. The RAFT copolymerisation of DOT with AAm and NIPAAm was investigated (Scheme 1). Copolymers were synthesised in DMSO:H 2 O mixtures (9:1, v:v), targeting different degrees of polymerisation (DP n = 157-625) with various initial molar fractions of DOT (f DOT = 0.00-0.14). The reaction kinetics were investigated for the copolymerisation between DOT and AAm with a total DP n of 315 and a f DOT of 0.05 (Figure ). Both monomers reached high conversions (> 85 % conversion) in 4 h (Figure ), indicating the successful insertion of DOT units into the copolymer. As observed previously, DOT is polymerised faster than AAm (k p = 0.020 min -1 and 0.012 min -1 for DOT and AAm, respectively). The increased polymerisation rate of DOT compared to AAm results in a copolymer with an uneven distribution along the backbone. Furthermore, good correlation between the initial DOT monomer feed (f DOT = 0.05) and the mole fraction of DOT in the final copolymer (F DOT = 0.06) was observed.