Overall, the uncertain and random ligand selection sampling covers broadly the chemical library and provides better overall description of the chemical space. However, to efficiently identify most potent binders other strategies, e.g. greedy or narrowing, are preferred. As we are not primarily interested in accurate description of medium and low affinity compounds, we can choose to sacrifice the accuracy of the general dataset quantification and proceed with those strategies that are capable to best uncover the most potent compounds.