Developing amorphous solid dispersions is another popular approach to enhance solubility, supported by over 20 commercially available products based on solid dispersions. Solid dispersions are commonly manufactured by spray drying and hot melt extrusion (HME). HME becomes challenging when the melting point of the drug exceeds 220 °C. Because the melting point of S-892216 anhydrous crystal is 243 °C, employing HME likely presents high risks. However, we found that, at the concentration of 10% w/w, S-892216 drug substance dissolved in acetone, a commonly used solvent for spray drying. Therefore, we chose spray drying to manufacture solid dispersions. After selecting the polymer candidate and drug content (Table and Fig. ), we prepared solid dispersion powders with various polymers, including PVPVA, using a spray dryer and confirmed that solid dispersion powders remained amorphous throughout storage (Fig. ). The component and composition of the developed solid dispersion suspension is shown in Table .