OpenBabel. The ligands where then prepared by detecting their root and Torsion tree. The proteins were prepared by deleting all heteroatoms, water molecules, polar Hydrogen were added. In order to know where the ligand would bind optimally the grid was specified to be the whole protein. The Docking was done in Autodock Vina (Trott and Olson 2010) that considered 9 different conformations of the ligand in each docking. The Docked results were obtained as PDBQT and txt. Files.