In addition, the design of the reward, that is, the evaluation function for molecular design and the DSS score, may also have areas for advancement. Careful setting of the evaluation function in molecular design is required because it directly affects the molecule to be designed; therefore, a suitable design for DyRAMO should be explored. Although multi-objective optimization was formulated using the Dscore in this study, other optimization strategies using weighted sums or Pareto solutions may also be promising. In this study, most of the reliability levels were low when the number of target property variables was high, as shown in Fig. and Table . This reflects the difficulty of the problem itself, but it could be improved by refining the molecular design model, careful setting of the molecular design, and modifying the DSS scores.