Overall, 2b, 2c, and 2d were converted by all variants with good activity, achieving conversions up to 90%. Interestingly, the O-methylation of the para-hydroxy groups of the methoxy-substituted substrates vinyl guaiacol 2c and canolol (4-vinyl syringol) 2d proceeded with much higher activity compared to 2a and 2b, leading up to 90% conversion. The presence of methoxy groups in 2d and 2c could favor the stabilization of the substrate in the pocket.