But another approach has recently attracted a lot of interest in the field of modern medicinal chemistry. In order to create a single hybrid entity with a dual mode of action, two physiologically active molecules (pharmacophores) must be combined. In comparison to the parent medications, these new hybrid compounds have the potential to increase efficacy, improve safety, be more affordable, and minimize the tendency to provoke resistance . The notion of hybridization has been shown to be a useful tool for creating novel antimalarial active ingredients .