To compare the chemical diversity of Nat-UV DB with the reference data sets, we employed the consensus diversity (CD) plot which is a simple two-dimensional graph that helps to visualize and compare the diversity of several compound data sets considering multiple representations such as chemical scaffolds, and fingerprint-based diversity . In this study, the CD plot was generated using the median paired similarity (ECFP4-1024 bits)/Tanimoto; x-axis) and the median paired scaffold similarity (Bemis-Murck representations using ECFP4-1014 bits/ Tanimoto; y-axis) . Both are established and are representative metrics of the scaffold and fingerprint-based diversity . Subsets of the compounds were retrieved from control data sets (Table ). The workflow implemented in KNIME software is available in the Supplementary material.