The Tyrosine kinase 2 (TYK2) and the hypoxia-inducible factor 2 alpha (HIF2A) test set coordinates and experimental data were derived from the protein-ligand benchmark (PLB) 0.2. The systems cover ring-breaking, R-Group changes, and ring size changes. In the case of TYK2, all molecule changes are localized in the same molecule region and all atoms have a very high overlap, making the system a very well-behaved system (Figure ).