In confirmation of compelling evidence which casts doubt on the reliability of the quoted biological data for this set of novel NInC hybrids, the in vivo antibacterial assays of these novel NInC hybrids together with their corresponding fragments and carboxylate ester analogues, all merit a full consideration. In addition, whilst this version of these novel NInCs, may, though it need not of necessity, not be clinically relevant, it is hoped that further optimisation of these potential leads, on the basis of these studies, paves the way for next-generation nitrofuranyl antibacterial drug conjugates.