Comprehensive frameworks for DNA origami technology methodologies have been established, covering origami design, synthesis, functionalization, and characterization. Different software tools like caDNAno, ATHENA, and Adenita have been employed for the design of DNA origami structures. Among these, Adenita stands out as it is the sole software capable of accommodating other biomolecules such as drug molecules, lipids, or proteins alongside DNA in the design process . Recently, a versatile computer-aided iterative design pipeline for DNA assemblies has been reported. This framework enables the efficient construction of large, complex assemblies with precise control over geometry, mechanical properties, and dynamics. The combination of top-down automation and bottom-up control will boost the design potential of intricate DNA assemblies, while also reducing the time required for their creation .