Multi-step reactions are trivial to conceive in SAVI; but daunting in their prospective sizes. For example, taking just the output of the click chemistry transform (transform ID 2875, Copper[I]catalyzed azide-alkyne cycloaddition), which produced 1 million molecules, as input for a second step (i.e. combining them with the standard BB compounds), yielded more than 50 billion reactant pairs. Taking the entire 1 billion current SAVI output set instead as new BBs can be estimated to yield 1 trillion actually accepted reactions. Techniques such as targeted growing into this huge space of 3reactant, 2-step, SAVI syntheses will be needed, which will be the topic of future reports.