Although no significant differences were observed within each polymer series, the two different platforms based on pEtEtOx and pPrMeOx obviously show a different pattern of drug loading for CUR and PTX, respectively. The polymers containing pEtEtOx tend to load more CUR than PTX, while the polymers containing pPrMeOx solubilize more PTX than CUR. In previous work of Lübtow et al., it was shown that even different positioning of a methylene group between the polymer side chain to the polymer main chain (comparing A-pPrOzi-A and A-pBuOx-A) can lead to a surprisingly specific drug loading for CUR and PTX, respectively. Here, the difference in positioning is between the amide side chain to the backbone branch, but also leads to a similarly specific drug loading of A-pEtEtOx-A and A-pPrMeOx-A for CUR and PTX, respectively. Specifically, comparing to literature with the different isomers, the order for maximum LC for CUR is A-pPrOzi-A (≈54 wt %) > A-pEtEtOx-A (≈40 wt %) > A-pPrMeOx-A (≈29 wt %) ≥ A-pBuOx-A (≈24 wt %). In contrast, for PTX, the order for maximum LC is A-pBuOx-A (≈48 %) > A-pPrMeOx-A (≈32 %) > A-pPrOzi-A (≈25 %) > A-pEtEtOx-A (≈18 %). R-IBU (red), S-IBU (blue) and RS-IBU (purple). Polymer feed was 10 g/L. The data is given as means ± SD (n = 3, with the exception of A-p RS PrMeOx-A/CUR=10/10 (g/L) which is n = 5)