Outside the differentiable training simulations, good agreement is also maintained between the converged APL and the experimental values, as reported in Table . In all cases, the error is around 0.03 nm 2 . Since the APL was computed naively by considering only the xy plane area, thus not considering membrane undulations, our values might underestimate the real APL. Therefore, values below the experimental values may be closer to the reference than they appear. These combined results indicate that the optimized parameters are transferable to larger systems and can be used for production runs.