Cellular and extracellular mechanical properties alterations take place upon aging. Fibroblast senescence is associated with a change in actin -from a faction that can be polymerized and depolymerized upon cell motility, to f-actin fibers, which are likely to impact cell motility and cell-cell communication. Motility changes are of significant importance for the innate immune system aging, in which neutrophils from aging individuals induce substantial tissue damage upon migration to sites of inflammatory signaling. The nucleoskeleton also undergoes changes upon aging, with the nuclear lamina becoming destabilized and concomitant extrusion of chromatin into the cytoplasm triggering the SASP in senescence. Lastly, extracellular matrix also changes with aging, which greatly affects cell performance. Enhanced rigidity and loss of elasticity, as a result of glycation crosslinking between collagen molecules, can be in charge of multiple age-related disease conditions such as hypertension with related kidney and neurological disorders. The field of biomechanics is thus considered highly relevant to the physiology aging and anti-aging strategies. 105