To demonstrate the utility of cg_pyrosetta to test structural hypotheses about foldamers, we investigate how side chain size in 1b1s models changes the model's minimum energy structures, energetics, and ability to form well-folded structures. We perform a series of folding searches to scan over a range of side chain sizes in a 1b1s model. This parameter scan was inspired from the wide range of side chain sizes observed in natural amino acids. The annealing schedule used for the side chain size parameter scan used the following annealing parameters: T i = 50 B , r a = 0.9, annealing was run for M = 50 cycles, and MC simulations at each temperature are run for N = 10000 steps. Each parameter set was repeated with 100 replicas, to identify a consensus minimum energy structure. Individual simulation replicas for the side chain size parameter scan took 50 ± 21 minutes to finish on single core processes, with variations occurring because of differences in minimization times for different models. In this scan, minimum energy clusters sampled from an average of 33.1