Indeed, there is a potential correlation between CNVs, neurological diseases, and aging. In centenarians and middle-aged individuals, the number of CNVs increases significantly, and genomic instability increases with age. CNVs may impact telomeres, potentially impacting human lifespan. Complex longevity traits may result from genome structural alterations, such as CNVs, that alter gene expression . The primary source of variation among human individuals is the deletions and duplications of chromosome segments (copy number variation, CNV). Furthermore, CNV has the potential to influence human evolution and the development of numerous diseases, including mental illness, developmental disorders, and cancer . Recurrent copy number variation (CNV) happens when homologous recombination (HR) happens between repeated sequences. Non-recurrent CNV, on the other hand, happens when non-homologous recombination mechanisms happen all over the genome .