In Eq. 5, T oven is the temperature of the oven in which the reactor is placed, d closest is the compositionaveraged closest interatomic bulk distance, and E sub b,C is the composition-averaged binding energy of subsurface carbon. The symbol ∧ corresponds to the "AND" operator. According to the SG rules, the full acetylene conversion can be associated with the temperatures of 100 and 150 • C and with systems presenting d closest and E sub b,C above certain thresholds. The relevance of the parameters d closest and E sub b,C indicates that bulk as well as surface properties of the metal NPs determine high conversion levels. In particular, the parameter E sub b,C highlights that the activity depends on the subsurface interaction with carbon. The candidate descriptive parameters obtained from the experimental characterization of the materials and the parameters reflecting the properties of the clean surface and the interaction of the surfaces and subsurfaces of the metal NPs with hydrogen do not appear in the description of the identified SG. Finally, we also note that the candidate descriptive parameter t OS , also offered in the SGD analysis, is not selected in Eq. 5. Indeed, we do not observe significant variation of X C2H2 as a function of t OS (see ESI for details). The 12 materials of the dataset are represented in the coordinates of the key materials-dependent parameters identified by SGD (d closest and E sub b,C ) in Fig. . In this plot, the bimetallic alloys, which are part of the SG, are shown as red circles. The monometallic systems, which are not part of the SG, are shown as black circles. The SG rules are represented by the dashed red lines and arrows, and the SG region is highlighted in red.