Hierarchical clustering dendrograms were computed to visualize similarities and differences between 3DDPD descriptors and dynamic behavior (represented by MD's RMSF) across targets. Python package Scipy was used to compute hierarchical clusters based on the Euclidean distance between non-null bits of 3DDPD or RMSF vectors. The accompanying representation of the descriptor or RMSF includes null bits that are derived from their mapping to the GPCR class A MSA. Plotting was done in Python using the package Matplotlib .