To compare the different methods of adding assay context for bioactivity modeling, assay-aware PCM models were trained and evaluated for different protein families. As a control, a single task PCM model was trained on all agglomerated data without assay context. The assay descriptors were evaluated using a single task model with the additional input of the assay descriptor. We evaluated assay-based transfer learning using PCM multi-task models, with the tasks corresponding to assay clusters.