We will again test M06-2X and ωB97M-V as representative functionals, using a variety of basis sets, and the corresponding interaction energies are listed in Table 6. The basis sets are standard except for minimallyaugmented ("ma") and heavy-augmented ("ha") versions of the Karlsruhe basis sets, which were introduced in Ref. 88. Due to the size of these complexes, we use the average of CP-corrected and uncorrected DFT/def2ma-QZVP interaction energies to estimate the DFT/CBS limit for the ligand-protein complexes. By examining the entries for def2-ma-QZVP in Table , one can see that the two values that are averaged lie within 0.8 kcal/mol of one another when ωB97M-V is used, and within 1.2 kcal/mol for M06-2X. This provides some measure of the uncertainty in establishing the DFT/CBS limit.