One dominant scaffold with the higher affinities were predicted to each of the best targeted central and lipid cavities, each one of them with hundreds of atom variations. To identify which one of those will show experimental anti-channel activities, there are no other computational methods. We are assuming that those with the higher affinities, would have more probabilities to bind. However, there are no evidences that the higher affinities will have better binding properties than some other with lower affinity. Furthermore, the strategies explored here only identified an small number of scaffold possibilities. The chemical space has many other that remain unexplored.