This study offers robust validation and establishes a proof of concept for the use of fragment GCNCMC in the context of fragment-based drug discovery. Given GCNCMC's dual capability as a free energy estimator and a rapid and accurate pocket detection tool, fragment GCNCMC holds significant promise. As the method matures and evolves, we will apply it to more interesting and pharmaceutically relevant targets, particularly those that require protein conformational change and/or water displacement.