Protein-protein interactome network. The PPi network with zero node addition and a highest confidence cutoff of 0.9 was created using the human proteome of the Cytoscape StringApp, which takes into account experimental and in silico interactions . The degree centrality of a node represents the number of edges the node has in a network, and the betweenness centrality measures the number of times a node lies on the shortest path between other nodes . The centrality indexes were calculated using the CytoNCA app , and the network was visualized through the Cytoscape software v.3.7.1 . Human proteins physically associated with the SARS-CoV-2 proteins, and adaptive and innate immune system proteins were differentiated by colors in the PPi network.