Benzoate which react with a reducing agent, Silicon Hydride (-SiH) present in PDMS surface as a constituent of the curing agent. This reaction leads to the evolution of nano-particles, e.g. that of Gold (AuNPs) and Silver (AgNPs), which alters the solid-liquid interfacial energy at the channel wall with consequent change in its deformation of the channel at the vicinity of its minimum wall thickness. In a similar experiment, we have monitored also physisorption of a solute from its aqueous solution on channel the surface.