In 2019, Nitschke group reported the exclusive formation of a pair of T-symmetric truxene-derived Zn4L4 tetrahedral enantiomers. These enantiomers have faces and vertices which possess a single stereochemical orientation. The ethyl chains that surround the inner cavity allow the smallest hydrocarbon guests (CH4 and C2H6) in solution to bind and may also deform easily enabling gaseous guests to diffuse into the cavity.