It is important to mention the use of NOAH supersequences to acquire different 2D NMR data within the same experiment. The time savings provided by these sequences are a consequence of the use of a single recovery time (parameter d1 on Bruker spectrometers) for all the modules (individual pulse sequence). These new sequences are receiving considerable attention from the NMR community specially for structure elucidation, but also for metabolomics (complex mixture) samples. A combination of a selective enhanced HSQC together with a TOCSY module yields data useful for library matching and confirmation by spin systems identification (using COLMARm) in around 60% of the total time required for the acquisition of both experiments independently; we can also advocate for the benefits of these from our own experience. This sequence can be downloaded from the genesis web portal () 23 as gns_noah2-SpT (seHSQC + TOCSY as suggested at ). Following the same rational described here, data acquired using the same NOAH supersequence gns_noah2-SpT could also be used for applications to MADByTE. There is virtually no sensitivity loss for using this experiment due to its specific construction and spin dynamics. Briefly, the HSQC data is collected using only the magnetization from 1 H directly linked to C, while the magnetization from 1 H directly linked to 12 C (~99%) is kept safe for the TOCSY module to produce comparable data. This isotopic magnetization selection is enabled by the zz-filter (or ZIP sequence) implemented in the HSQC module. Other combinations are being tested to combine different modules to enable the acquisition of HMBC, HSQC, and TOCSY (or HSQC-TOCSY) data within the same NOAH supersequence.