Chromatographic separation was achieved using an ACQUITY UPLC BEH C18 Column (130Å, 1.7 µm, 2.1 mm x 100 mm, Dublin, Ireland). Mobile phase A consisted of water supplemented with 0.1% formic acid (FA) and mobile phase B consisted of ACN supplemented with 0.1% FA. Analysis was performed with a flow rate of 0.5 mL/min using the following program: 0-12 min gradient of 10-80% mobile phase B, 12-14 min at 100% mobile phase B. Column temperature was maintained at 50 °C. The mass spectrophotometry study was performed with Agilent 6546 LC/Q-TOF operating in the positive ion mode.