In the case of single objective optimization the acquisition function was the expected improvement; in the case of multi-objective optimization the acquisition function was the expected hyper-volume improvement. The quantile for splitting observations into 'good' and 'bad' trials was set at 25 %. This information is summarized in Table . The number of initial observations is less than the full 140 hyperparameter trials because a) some trials failed to converge an MSM, and b) in the case of Chignolin, some MSMs did not have a resolvable value of t 3 .