The coaction between transport mechanisms and reactions kinetics is complex and crucial for maintaining musculoskeletal homeostasis. For instance, the rate of lactate clearance through diffusion can influence muscle fatigue and recovery. Impaired diffusion of oxygen leads to a shift in metabolic pathways, favoring anaerobic glycolysis and the accumulation of lactate. This metabolic shift can disrupt muscle contractility and contribute to fatigue and pain . Furthermore, enzymatic activities controlling the degradation of extracellular matrix components are contingent upon effective transport mechanisms, revealing a critical link between transport phenomena and tissue integrity in conditions like tendinopathy . Kinetic processes such as mineralization and resorption in bones depend on the timely transport of calcium and phosphate ions to and from bone surfaces . The kinetics of cytokine signaling in inflammatory diseases is also tightly linked to their effective transport through the synovial fluid and interstitial spaces . The coupling of transport and reactions also influences the dynamic balance of osteoblast and osteoclast activities regulated by signaling molecules like receptor activator of nuclear factor kappa beta ligand (RANKL) and osteoprotegerin, where the transport and local concentrations of these molecules determine bone remodeling rates . Disruption in the transport or reaction rates can lead to pathological states, as seen in rheumatoid arthritis where synovial inflammation and altered cytokine transport induce joint destruction.