Rapid, sensitive and accurate detection of highly contagious viruses (e.g. SARS-CoV-2) is urgently demanded for the prevention and control of virus pandemic . The advantages of AIEgen i.e. luminosity, photobleaching resistance and biocompatibility promote their applications in ultrasensitive detection of viruses . Xiong et al. demonstrated a dual-modality readout immunoassay platform based on AIEgen for detecting of viruses . The mechanism of dual-mode detection of virus is shown in Figure . A water-soluble multifunctional AIEgen (TPE-APP) with an enzymatic cleavage group was designed. The probe can be hydrolyzed by alkaline phosphatase (ALP) to form water-insoluble TPE-DMA aggregate and a highly redox species. On one hand, the TPE-DMA aggregate is intensively fluorescent. One the other hand, the redox species could reduce silver ion to generate a silver nanoshell on the surface of AuNP (AuNP@AgNP) that leads to the blue shift of the localized surface plasmonic resonance (LSPR) peak of AuNPs, displaying a pronounced color change from red to yellow and further to brown, which can be differentiated by naked eyes. By further taking advantage of effective immunomagnetic enrichment, enterovirus 71 (EV71) virus, as an example, can be specifically detected with a limit of detection concentration down to 1.4 copies/μL under fluorescence modality and in a broad range from 1.3 × 10 3 to 2.5 × 10 6 copies/μL with naked eyes. Most importantly, EV71 virions in 24 real clinical samples are successfully diagnosed with 100% accuracy. Compared to the gold standard polymerase chain reaction (PCR) assay, this immunoassay platform is not only much more convenient and cheaper, but also show excellent quantitatively capability, high sensitivity and strong anti-interference ability, paving great prospect for handy preliminary screening and high-accuracy in clinical diagnosis of viruses. Reproduced from Ref. with permission of American Chemical Society, © 2018.