A number of different strategies have been developed to shift photoswitch responses bathochromically and up to the near infrared (NIR) spectral region. They include photophysical methods such as two-photon absorption, upconversion, or sensitization as well as intrinsic tailoring by substitution approaches, or developing novel photoswitch motives with suitable core-chromophores altogether. Currently, however, there seems to be a limit at the 1000 nm short wavelength infrared (SWIR) boundary, beyond which viable photoswitching cannot feasibly be realized. We have recently reported on the perianthracenethioindigo (PAT) chromophore, which enables all-red light and NIR photoswitching via direct excitation. Its highly advantageous property profile includes NIR absorption up to 850 nm, large photochromism with maxima separations of more than 140 nm, strong color contrast between bright green and deep blue, good quantum yields, and high thermal stability of the metastable state. Subsequently we have demonstrated utility of the unique photoresponse of PAT by combining it with another indigoid chromophore and realizing the first all-visible orthogonal photoswitching. Fully path-independent enrichment of either of the four possible switching states could be achieved and additionally also a functional fluorophore could be added to the mixture without disturbing orthogonality of the photoswitching. This combinatorial system was then applied for multi-photochromic polymers and all-photonic molecular computing.