Although signal overlap complicated the analysis of the NOESY spectra for peptide 15c, we identified H N -H N cross-peaks (or overlapping potential cross-peaks) between all neighboring H N atoms and between all H N atoms and aromatic side chains (Figure ). In contrast, for p3 in water, only H N -H N contact between Arg1 and Arg2 and contacts between H N of Arg1 and Dip7 side chain, as well as between H N and the side chain of Dip5, were detected (Figure ). For p3 in the presence of DOPC/cholesterol liposomes mimicking mammalian membrane (Figure ), only a few contacts between backbone HNs and aromatic side chains were found, including Arg1-Dip7 and intra-residue contacts between Trp6 and Dip7. For 15c, a similar network of contacts was detected in water and in the presence of DOPC/cholesterol liposomes. These included sequential H N -H N contacts between Arg1-arg2, arg4-dip5, and dip5-Trp6; contacts between H N atoms and aromatic side chains of dip5, Trp6, and dip7 as well as between Arg1 and the side chain of dip7 (Figures and).