We find that the distribution peaks at a low similarity score of 0.39. Even when recomputed with 12000 molecules, it peaks below 0.6, with no significant peak at 1.0. This plot is shown in Figure of the SI. Compared to a previous method that dealt with generating varied molecules , this distribution implies substantial variation in our molecules. However, at this stage (before any training), only 24% of the molecules were found to be synthesizable as classified by SYBA .