Among all cancer types, lung cancer is prevalent and account for at least 18% of all cancerlinked mortalities . Cigarette smoking constitutes the major risk factor for the development of lung cancerwith approximately 90% of lung cancer cases linked to cigarette Ssmoking alone . Consequently, smokers are prone to developing cancer cells and resisting cancer treatment than non-smokers . Essentially, lung cancer can be classified into two main types namely, small cell lung cancer (SCLC) and non-small cell lung cancer (NSCLC), with the latter accounting for approximately 85% of all lung cancer cases . There have been advances in studying oncogenes and mutation of tumor suppressor genes toward the development of drug candidate for treating lung cancer . Among the targeted genes, a rat sarcoma viral oncogene homolog, KRAS is implicated in many lung cancer cases .