In order to extend the capabilities of the impurity prediction and bias the predictor to find impurities from reaction intermediates, we introduced a reaction intermediate in the paracetamol synthesis route. Specifically, we split R2, H 2 reduction process, into R2A and R2B. R2A results in the production of para-hydroxoaminophenol from paranitrophenol, and R2B completes the reaction as earlier leading to the formation of para-aminophenol. However, we did not observe the production of any new impurities due to the reaction intermediate. We believe that this might be related to the reaction intermediate case not being a part of the training datasets, and thus, the predictor not having any explicit idea to predict the impurities. However, it is supposed that the introduction of intermediates in different reaction routes might result in interesting results.