Each system utilised an initial simulation cell of size L x × L y × L z = 10 × 10 × 200. This size was settled upon after performing calculations for a series of different box sizes to ensure finite size effects are ruled out. Further information regarding these effects can be found in the Supporting Information. For the dodecane-water system, the initial simulation setup was constructed such that each of the two components were placed in either half of the simulation cell. Periodic boundary conditions were adopted in all three dimensions. In this case, the oil-water system comprises two interfaces, one at z ≈ L z /2 and one at z ≈ 0. In the final result, whilst equal in number of beads, water and dodecane occupy slightly different volumes due to their different densities. All simulations to determine the interfacial tension values were performed initially under a NPT ensemble at starting reduced density of ρ = 3.0.