The first small-angle X-ray scattering (SAXS) experiments for TX-100 micelles, concluded that the TX-100 micelles were best described as oblate ellipsoids, but the authors admitted that their model did not describe the data at high q values where the internal micellar structure is expected to contribute. Similar conclusions were obtained using small-angle neutron scattering (SANS) . Stubičar et al. later performed more SAXS measurements under different conditions and reported that models with sharp boundaries between the hydrophobic and hydrophilic parts would not accurately describe the data, exposing limitations of the core-shell model for this system. A spherical model that assumed the intermixing of the octylphenyl group with the EO chains was found to be most compatible with the pair-distance distribution functions (P (r)). This was later corroborated by 2D NOESY and 1 H NMR findings, where Yuan et al. claimed that the TX-100 micelles were spherical and that the EO chain must coil, bend, and align along the surface of the hydrophobic core when forming the micelles. Denkova et al. also found that there was no distinct boundary between hydrophobic and hydrophilic moieties, and Giorgio et al. , based on their 2D NOESY data, suggested that molecules should be arranged in at least two layers.