While double hybrids generally give better results than hybrids, the additional computational cost can be prohibitive for large active site models/QM regions; our most cost effective recommendations are therefore ωB97M-V/def2-TZVPP and ωB97X-V/def2-TZVPP, which give reliable and robust results across many different types of enzymes. We hope these recommendations help improve the results of computational mechanistic studies of enzymes, and help the ongoing efforts to flesh out the field of DFT benchmarking for transition metal chemistry.