It has also been shown that during hydrothermal curing carbon-carbon bonds can form and contribute to formation of solvent stable particles at 190 °C. As a control experiment we hydrothermally cured LNPs under the same conditions at 150 °C. Interestingly, these particles also showed good solvent and pH stabilty, however, they showed colloidal stabilty by time and aggregated while cured HLNP did not show any sign of aggregation in 6 months (Figure ).