The L1 regularization penalizes the absolute difference between the optimized torsion parameters and their initialized values, |ΔΦ |. Usually, the regularization term prohibits large deviations from the initial parameters. However, over-fitting is less of a concern during bespoke parametrization, and so the default prior widths ( ) on the parameter restraints are increased (from 1.0 to 6.0) so as to not limit the maximum achievable accuracy of the optimization due to poor initial guesses.