Submission TFE-NHLBI-TZVP-QM was a QM-based physical method that used the Def2-TZVP basis set for all calculations. Calculations were performed in either Gaussian 09 or Gaussian 16. Structures were optimized with the B3LYP density functional and were verified to be local minima via frequency calculations on an integration grid with harmonic frequencies. Details of solvation handling were not included in the method description.