Traditional round-bottom flask chemistry is still the major strategy for reaction optimization; however, it is limited by the capacity of a human experimentalist and experimental set-up can vary between chemists, unintentionally introducing sources of error. Hence, we chose to employ high-throughput experimentation (HTE) to conduct experimental arrays in parallel, increasing the rate of data generation and improving reproducibility. To the best of our knowledge, this is the first application of this chemical transformation into a HTE setting.