In conclusion, we have completed the total synthesis of nimbolide (1) in 11 steps from α-methyl-(R)-carvone (13). Our strategy relied on a diastereoselective borylative Heck cyclization to forge the trans-decalin present in 1 and a stereoretentive SN1 etherification to bring together two complex fragments. We expect that these approaches developed herein will be valuable for the synthesis of nimbolide analogs and other highly oxidized C-seco limonoids. Furthermore, studies to expand the synthetic utility of this borylative Heck reaction are underway and will be reported in due course.