The sobEDA method described above does not include effect of geometry distortion of fragments due to interaction, does not taking solvation effect into account, and ignores any thermodynamic effects. However, in some situations these factors play nonnegligible roles. For example, distortion energy of fragments is critical in the analysis of interfragment interaction at a series of points along the path of chemical reactions, as highlighted by the known distortion-interaction analysis; polar solvent environment significantly weakening interaction between solute molecules with obvious polarity; Entropy penalty effect markedly hinders complexation between molecules when temperature is not quite low. Since these factors can be straightforwardly evaluated via any mainstream quantum chemistry as follows by users, they are not explicitly considered in the standard definition of sobEDA.