The Protase of COVID 19 made 221 pocket similarity above 0.6, and a total of 47 drugs, after docking the cut was made on less than (-8.0) and the top result must be on the predicted binding site, only 9 of them were able to achieve this ( Chlortetracycline, Dequalinium, Gemcitabine, Raltitrexed, Roflumilast, Sildenafil, Suvorexant, Citicoline, Vardenafil ) table (4). It's worth mentioning that tetracycline and doxycycline did bind to the predicted binding site but did not make the cut.