In literature, several methods for reaction structure completion were published. Grzybowski et al. manually curated around 100,000 generalised reaction rules with complete understanding of reaction participants and stoichiometry. Their templates are now linked with commercial software SYNTHIA TM and can guide retrosynthesis and analyse carbon efficiency based on mass conservation. However, human development of reaction rules is far from the aspiration of exploring a very large chemical space of feasible molecules and reactions. On the other hand, the automatically extracted templates 7 are also not reliable for reaction completion, since most of these templates were generalised from open-source USPTO reaction dataset 2 in which the reactions were not complete. A "golden dataset" with complete reactions could be an ultimate solution. However, such large-scale reaction dataset does not exist today.