During this task, researchers are faced with many challenges from compiling a representative subset of data for the diverse set of tasks seen in QSPR modeling to choosing the right method to obtain statistically sound results . However, even more fundamental problems such as the dominance of median predictions or combining data sources can plague benchmarking results. Therefore, even with the long history of the QSPR modeling field, it is clear that benchmarking methodologies are important, but not problem-free.