Particular T-cell surface markers (CD3, CD4, and CD8) on nucleic acids enrich T-cells with aptamers. Since aptamers are designed to bind selectively, they can isolate T-cells through a three-step process: aptamers are conjugated to magnetic beads, incubated in a cellular mixture, and separated by a magnetic field to isolate the bound T-cells. This method effectively targets specific cells and is cost-efficient in contrast to the previous cell separation techniques based on antibodies. In this research paper, we have advanced the idea that aptamers are an ideal way to enhance CAR T-cells. Despite promising results, the research done has some limitations. For instance, molecular docking simulations depend on the algorithms made from predefined data. Therefore, lab experiments should be performed as a next step to confirm the results further.