A variety of tools have been developed to generate conformers, including BALLOON , Confab , FROG2 , MOE , OMEGA and RDKit . The search algorithms implemented in these tools can be broadly classified as either systematic or stochastic. A systematic method deterministically enumerates all of the allowed torsion angles for each rotatable bond in the molecule, and always outputs the same conformer with the lowest energy. This approach is restricted to molecules with a small number of rotatable bonds because of the combinatorial explosion of states as more search dimensions are added. Stochastic methods such as Monte Carlo simulated annealing , distance geometry and genetic algorithms , sample random values for the torsion angles, sometimes restricted to predefined ranges. Since the method is dependent on random numbers, the output conformation may vary, but they permit problems with higher dimensions to be handled.