The strong basic character of F -in anhydrous aprotic environments is known. It usually arises in systems where there is a weak interaction between the solvent/counterion and the fluoride anion, which drastically affect its reactivity. While most of fluoride sources, such as inorganic salts or tetramethhylammonium fluoride (TMAF), are not soluble in common organic solvents, higher tetralkylammonium cations are compatible with many solvents, including apolar ones. They, however, suffer limited stability toward the Hoffmann degradation, especially at high temperatures. Performing the reaction in a short time and at low temperatures becomes therefore of primary importance.