An interferon regulatory factor 2 binding protein 1&2, also known as interferon regulatory factor (IPR022750), functions as a zinc finger. There are two types of interferon regulatory factor 2 binding proteins: IRF-2BP1/2 and IRF-2BP-like, which is also known as IRF-2BPL or C14orf4. They are nuclear transcriptional repressors that bind to the C-terminal repression domain of IRF-2 and stop basic transcription and enhancer activation. Familial mutations in IRF2BP2 cause common variable immunodeficiency (CVID).