Chemical reaction optimisation is a challenging and resource-intensive yet essential process in chemistry. Chemists explore combinations of various reaction parameters (e.g., reagents, solvents, catalysts) to simultaneously optimise multiple objectives such as yield and selectivity. In process chemistry, reaction optimisation faces more rigorous demands on reaction objectives than in academic settings, encompassing additional economic, environmental, health, and safety considerations . These factors often necessitate the use of lower-cost, earth-abundant, and greener alternatives, such as replacing traditional palladium catalysts with nickel , and selecting solvents that adhere to pharmaceutical guidelines . Optimal reaction conditions satisfying these stringent criteria are often substrate-specific and challenging to identify generally for a given set of reactants.