There are only several parameter sets that result in a decreased ∆∆G prediction accuracy for OpenFF-2.0 compared to OpenFF-1.0. Namely, changes in parameters describing sulphur-containing groups like thioethers (a38, b51) or sulfonamides (t145, t148) and torsions (t13 and t14) describing cyclopropyl groups appear to have a detrimental effect on binding affinity accuracy.