We find that, for the overwhelming majority of manuscripts, only mandatory data requirements are met. This suggests that the positive promotion of FAIR principles by the cheminformatics community has had little effect amongst mainstream researchers to date, and journals/publishers have a key role to play in driving an improved data-sharing practice amongst researchers in organic chemistry. Significant culture change is required to develop author familiarity with FAIR data principles and promote their application. This cultural change must be supported by mandated sharing of key data types, promotion of common file formats, and support for researchers to reduce the burden of curation. Mandates for deposition, standardized data formats, and centralized repositories are all necessary to enable compliance with FAIR principles .