To further investigate the performance of the implicit-solvent models, the IR spectra of 2-methoxyethanol in five different solvents were predicted, and the OH vibrational frequencies were compared against experimental data from Ref. . Note that only the frequencies were predicted, which were analyzed using a Boltzmann weighting according to the predicted free energies of the conformers. The intensities resulting from a changed dipole derivative were assumed constant. The predicted OH vibrational spectra and the comparison of the frequencies against experiment are shown in Fig. . While the predicted frequencies of the QM calculations with SMD and openCOSMO-RS are very similar to each other independent of the solvent, the calculations with QM-GNNIS show larger solvent effects, which is in agreement with experiment. Note that the absolute values of the computed versus experimental wavenumbers are shifted by approximately ∼200 cm -1 for all methods. We hypothesize that this shift is a result of the level of theory used as it is well known that frequencies computed with DFT methods often suffer from a constant offset . From Fig. , we conclude that the QM-GNNIS model seems to capture key effects from the interaction between the solvent and the OH group of 2-methoxy-ethanol that give rise to a difference in the vibrational frequency unattainable by the other implicit-solvent models. This finding is especially striking as new conclusions can be drawn based on these results that provide an alternative explanation for the solvent-specific frequencies. In the original publication Ref. , the authors surmised that the difference in frequency resulted from an opening of the intramolecular hydrogen bond and concluded that the frequency shift was directly linked to the 'open' versus 'closed' pseudo-five-membered intramolecular ring. Our results, however, indicate that it is rather the subtle differences of the closed ring conformers in conjunction with the direct effect of the solvent interacting with the OH group that shift the vibrational frequency. This observation highlights the proposed QM-GNNIS model as a versatile approach that can accurately predict the solvent-dependent conformational ensemble of molecules while also providing access to experimental properties such as IR frequencies.