Two new applications, Extended Similarity Indices and the Structure-Activity Relationships Matrix (SARM) approach and its deep learning extension (DeepSARM) , were presented at the Colloquium by Quintana (Talk 12) and Bajorath (Talk 13), respectively. These applications support multiple procedures such as analog series identification (fragmentation?), analysis of de novo drugdesign signatures, similarity searching, and visualization of SAR and chemical spaces.