General procedure E for the dehydration of primary amides. Cyanuric chloride (1 mmol, 1 equiv.) was dissolved in ice cooled DMF (dry) and stirred for 10 min before the primary amide (1 mmol, 1 equiv.) was added dropwise as a solution or suspension in DMF (dry). After addition, the reaction was allowed to reach 25 °C and was stirred overnight. The reaction was quenched with sat. NaHCO3 solution and extracted with EtOAc (4 × 15 mL). The combined organic phases were washed with brine, dried over Na2SO4, filtered, and concentrated under reduced pressure to afford the nitrile.