The simplicity of forming P3N-ligands allowed for several to be constructed the screening of which led to the most effective catalyst following its chelation to a (presumably reduced) palladium(II) salt (Pd(OAc)2). As seen in Table , several secondary amines were selected and converted to the corresponding homo-or mixed-P3N ligand (i.e., L1 -L7). A model Sonogashira reaction between aryl halide 1 and alkyne 2 leading to product 3 was used to determine the best match between the ligands in Table and the intended use in Pd-catalyzed couplings. Clearly, (n-Bu2N)3P (entry 4) appeared to be the most effective, affording product 3 in high yield. The preparation of (n-Bu2N)3P (L7), made using this 6:1 ratio of amine to PCl3 in dry ether (three equivalents of n-Bu2NH used for removal of the HCl by-product) initially involved a purification via distillation under vacuum and at high temperatures. However, it was soon realized that purification was not needed, as the newly formed ligand was ready for immediate use.