Hypoxia is associated with an elevated incidence of Alzheimer's disease (AD). Aβ production and tau phosphorylation are influenced by hypoxia at numerous locations . In addition, hypoxia elevates the concentrations of inflammatory molecules (IL-β1, IL-6, and TNF-α), which have also been linked to neurodegeneration. Chronic hypoxia induces neuroinflammation by activating microglia, the resident immune cells in the brain, and increasing reactive oxygen species and proinflammatory cytokines. These features are common to many degenerative central nervous system (CNS) diseases . The activation of several kinases associated with tau hyperphosphorylation in neuronal cells, including ERK, GSK3β, and CDK5, is enhanced by hypobaric hypoxic exposure . Tau hyperphosphorylation in the hippocampus and diminished memory are observed in rats that have been subjected to hypoxic stress .