Our proposed algorithm succeeded in finding the correct mappings for all 241 reactions without optional postfiltering (indicated as 'no filter'). In 151 out of 241 cases (63%), our enumeration algorithm identified correct and unique mappings without postfiltering. We also applied two types of optional filters: a filter minimizing the number of bond cleavages and formations involving a hydrogen atom (i.e., the number of hydrogen atoms moving during the reaction, filter1), and a filter minimizing the number of bond multiplicity changes after applying filter1 (filter2). Filter1 considerably increases the number of cases with unique correct nonequivalent mappings from 151 (63%) to 195 (81%) by filtering multiple nonequivalent mappings. This filtering process incor-rectly excluded the correct mappings in only six cases. This result suggests that the number of hydrogen atoms moving during the reaction is an effective criterion for identifying chemically correct mappings in most reactions. Fil-ter2 further increased the number of cases with unique correct nonequivalent mappings to 224 (93%), while increasing the number of failure cases by only one. Additionally, after applying the filters, our framework rarely returned three or more nonequivalent mappings in this dataset.