Two series of PBS-DLS-PEG copolymers were synthesized via melt polycondensation using non-toxic magnesium-titanium butoxide catalyst. This catalytic system has been already used for different type of reactions, including polycondensation of poly(butylene terephthalate)(PBT)-based and poly(butylenesebacate)-based copolymers . In our previous work, we utilized a heterogeneous titanium dioxide/silica dioxide catalyst (C-94) for the two-step polycondensation process. However, when employing magnesium-titanium butoxide catalyst, significant reduction in both transesterification and polycondensation reaction times were observed. Specifically, the transesterification time decreased by 50%: from 80 to 40 minutes (see Table in Supplementary information), while the polycondensation time decreased by 28.6%: from 140 to 100 minutes. These findings underscore the superior catalytic efficiency of the magnesium-titanium butoxide catalyst, enabling a more rapid and efficient synthesis of the desired polymers compared to the heterogeneous catalyst C-94. These reduced reaction times have the potential to enhance productivity and cost-effectiveness in large-scale polymer production processes.