To overcome these obstacles and align with the FAIR (Findable, Accessible, Interoperable, and Reusable) framework , we present Pan-ReDU, as a major update to ReDU . Pan-ReDU represents an effort to harmonize sample metadata across multiple repositories (MTBLS, NMDR, and GNPS/MassIVE) and integrate them with their respective raw data files. This also includes a software ecosystem and infrastructure, enhancing accessibility for both small-scale and large-scale metabolomics data reanalysis across three, and potentially more, data repositories in the future (Figure ).