We note that owing to T's large windows, its hydrophobic cavity is more exposed to water than that of capsule C, which might entail its lower solubility and facilitate crystal nucleation, even in the presence of excess C. In the presence of these seeds, the C→T equilibration can be rapidly accelerated as T crystals continue to grow. We also note that cage C is chiral and speculate that the presence of two enantiomers might further hamper crystallization. One of these enantiomers is shown in Figure , with all of its four TImB panels "rotating" in the counter-clockwise direction.