The number of unique fragments indicates a higher degree of structural diversity. The PNs databases are diverse with respect to the reference databases. Similarly, CRAFT shows diversity, although it shares more fragments and "Fragments RO3" in common with COCONUT than with other libraries. The reason for this could be that overlapping the fragments that comprise CRAFT are PN-derived. This diversity is clearly reflected in CRAFTs' library, which incorporates a wide array of structural frameworks derived not only from natural and semisynthetic compounds, and synthetic products. The library includes compounds featuring fused-ring systems, encompassing a broad spectrum of structures that spans from commonly found ring systems (e.g. pyridine) to innovative bicycles (e.g. pyrazolo[1,5-c]pyrimidine). Such a varied collection of scaffolds underscores the library's potential for occupying a wide range of the available chemical space. More specifically, CRAFT fragment library revealed a total of 122 distinct scaffolds, highlighting the rich structural diversity within the library. Among these, the top five scaffolds after benzene are furo[3,2-b]pyridine 1, pyridine 2, indazole 3, imidazo[1,2-a]pyridine 4, and piperazine 5 (Figure ). These scaffolds represent important structural motifs commonly encountered in bioactive molecules. Notably, other significant scaffolds included 1H-pyrazolo[3,4-c]pyridine 6, and 2,6-naphthyridine 7 (Figure ), which exemplifies novel scaffolds synthesized previously by our group. Further analysis indicated that only 10 of the 122 scaffolds were non-heterocyclic, while 88 contained nitrogen within their core structure, suggesting a strong emphasis on heterocyclic chemistry. Moreover, 77 of these scaffolds were fused, further supporting the hypothesis that many of them closely resemble natural product structures, which are often characterized by fused-ring systems. This unique composition not only broadens the chemical diversity of the library but also explains why it demonstrates a higher overlap with the COCONUT database compared to other chemical libraries, providing a richer source for exploring bioactive and functional molecular scaffolds.