The volume distribution (Vd) of the selected hybrid compounds were found to be between 0.38 L/kg to 4.513 L/kg according to results in Table . This results fall in The proper Vd is in the range of 0.04-20 L/kg. An individual drug's propensity to either stay in the plasma or disperse to different tissue compartments is represented by the volume distribution (Vd), a pharmacokinetic parameter. It establishes a connection between the overall amount of drug in the body and its plasma concentration at a particular moment. This parameter is affected by physiological plasma volume, physiological tissue volume, PPB, and tissue binding. The distribution process is the movement of the medicine between the intravascular (blood/plasma) and extravascular (intracellular & extracellular) compartments of the body. In every area of the body, drugs coexists in balance between a protein-bound and free form. Drugs in the blood will ultimately be metabolized by the liver and kidneys and evacuated from the body .