Analyzing capillary blood samples was recently shown to be possible via microneedle-based systems due to their direct and minimally-invasive whole-blood extraction approach. As a minimally invasive technique, the microneedle insertion is almost painless and devoid of discomfort, ensuring a positive patient experience during the sampling process. Moreover, the tiny needle minimizes tissue trauma, thereby reducing the likelihood of complications such as hemolysis and the risk of infection throughout their use . The direct detection of capillary whole blood can eliminate the need for traditional laboratory equipment for the smaple manipulion and pre-treatments, thereby enhancing healthcare accessibility and facilitating point-of-care testing.