C-C bond activation has been achieved on the surface of heterogenous catalysts, within the active sites of enzymes, and under homogenous conditions using metal complexes. Reported reactivity typically employs a late transition metal (Rh, Ir, Pd, Pt) as part of the active site for C-C activation. Reactivity often follows classical mechanisms, divided into two broad classes: i) the direct oxidative addition of the transition metal to the C-C bond; ii) -alkyl elimination at a metal centre (Figure ); -Alkyl migration can be defined as a sub-class of -alkyl elimination, wherein the substrate remains intact on the transition metal throughout the pathway.