The proposed method is tested by fitting the four kinetic parameters (𝐴, 𝐸 𝑎 , ΔΔ𝐺 ‡ solv (298 K), ΔΔ𝐻 ‡ solv (298 K)) to the experimental data of liquid phase rate constants and calculating the rate constants with the fitted parameters. For each reaction, the four kinetic parameters are optimized by minimizing the following loss function: