In this study, the influence of plasticizers on four poly(2-oxazoline) and poly(2-oxazine) based ABA triblock copolymers to decrease the fabrication temperature via MEW was studied. The addition of triethyl citrate and ethylene glycol resulted in printable polymer blends with improved fiber stacking for the blends comprising triethyl citrate. Through the addition of the model drug IND, the fabrication temperature could be decreased to 130 °C, reducing the risk of degradation of both, drug and polymer. The addition of triethyl citrate did support the fiber stacking of the drug loaded microfibers. Interestingly, the addition of the plasticizer influenced the dissolution profile of the scaffolds differently depending on the polymer used, despite the very similar chemical structure of different polymers. Our results provide a starting point to better understand and optimize drug loaded and rapidly dissolving microfiber scaffolds.