does not significantly modify the UV-Vis spectrum of the molecule. Only modifications involving the quinolone ring were reported to influence the absorbance spectra. Thus, it is possible that an electrochemical oxidation of TDMQ20 is taking place during the first steps of oxidation (+0.45 V, Figure ), affecting the aliphatic chain of TDMQ20 (Scheme 1), adsorbing the molecule to the carbon WE surface, without affecting its UV-Vis spectra. This hypothesis can be confirmed by Bidim-SEC, comparing the information provided by normal and parallel configuration. By correcting the absorbance in normal configuration, An, with the absorbance in parallel configuration, Ap, (describe in details in SI) using the optical path-lengths as follows: