Table . Binding orientations of guests g1 (methylcyclohexanol) and g2 (rimantadine) with cyclodextrin hosts. Binding orientations of guests complexed with hosts determined by NOESY NMR by the Gilson lab . The orientations are summarized here to cross check with binding mode(s) used by SAMPL7 participants and ascertain the binding mode(s) which may contribute to accurate binding affinity predictions (or lack thereof). In some cases, experiments did not allow determination of a binding mode; such cases are labeled ND. Secondary Secondary charging method, host conformer, guest pose, water model, etc.) to ascertain its impact on predictions. In previous challenges, participants were allowed multiple ranked submissions; the shift to a single ranked submission per participant is new to SAMPL7.