Importantly, molecular docking data on specific and similar binding by both lactyl-CoA and acetyl-CoA indicated a strong binding to the reported amino acid residues such as ARG1312, GLU1423, LYS1426, LYS1427, GLU1477, and ARG1478. These amino acid residues interact with several known natural and synthetic substrates including acetyl-CoA, lysyl-CoA, A-485, and I-CBP112. It is interesting to note that lactate did not have any binding affinity within the active site of HAT p300