For validation under point-of-care conditions, we determined the glucose concentration in a human blood sample using the internal standard addition method with the GOx-based sensors and the integrated AOx-based O2-scavenger (Figure ). The blood was tested without any treatment except for the addition of specific glucose concentrations (5 to 10 mM) as internal standards. Due to the presence of chloride ions in the sample matrix (blood), which shift the potential of the pseudo RE of the SPEs, we set the applied potential to a higher value (0.6 V vs pseudo RE) than for the measurements in buffer. Without the O2 scavenger, the obtained charges are low and non-linear with respect to glucose concentration. In contrast, in the presence of the integrated O2-scavenger, the electrical charges are about 3 times higher and proportional to the glucose concentrations. The value obtained from this measurement is 0.187 mM. This demonstrate that the O2 scavenger is effective for suppressing O2 interference even in complex sample matrices such as blood, qualifying it for point-of-care sensing applications. scavenger (blue dots) Eapp = 0.6 V vs. pseudo RE for 10 minutes. Glucose (5, 7, and 10 mM) was added to the blood. The screen-printed electrodes were modified with Os-complex modified polymer (50 wt%), GOx (40 wt%), and PEGDGE (10 wt%) with total loading 200 μg cm -2 . The scavenger containing AOx (40 U mL -1 ), CAT (4000 U mL -1 ) and paraformaldehyde (saturating concentrations ~50 mg mL -1 ) is integrated within the capillary channel of the SPE. Data are the average of n = 3 repetitions and error bars show standard deviation.