The DUDE-Z molecule library was smaller and less diverse than the D4 and AmpC libraries and did not undergo this diversity analysis. DUDE-Z virtual actives were limited to the top 100 as opposed to the top 10k, and the DUDE-Z Goldilocks library, which averages 3.6 molecules per scaffold, did not accurately represent the diversity typically found in ultra-large screening libraries like ZINC-22, which averages 46.7 molecules per scaffold.