Unlike the MIF and PDE2a systems, these complexes equilibrated quickly, meaning that the accelerated convergence afforded by the adaptive protocol did not provide a substantial advantage (Figure ). However, the fact that the adaptive protocol produced equivalent results to the non-adaptive protocol on an "unseen" test set suggests that it is robust and that our "optimal" parameters are likely to perform well for other systems. Furthermore, the adaptive protocol performed sensible optimisations without any human intervention, for example reducing the number of λ windows for the restrain stage from 12 (which produced very high overlap) to 2. A more detailed analysis is given in Section S22.