Now that of the mechanical stereogenic units of simple [2]catenanes and [2]rotaxanes have been delineated and concepts developed to allow their stereoselective synthesis, it is reasonable to propose that, 62 years after such systems were first discussed, we have finally reached the end of the beginning of the study of mechanical stereochemistry. Such molecules have already been used as the basis of molecular machines, 14d enantioselective sensors and catalysts, and chiroptical switches, 39 work which will only accelerate as methods to synthesize them improve. Moreover, we suggest it is time now to set our sights beyond these simple structures and develop methodologies for the systematic synthesis of structures whose stereochemistry arises due to the presence of additional crossing points 40 or larger numbers of interlocked components 41 so that the potential benefits of such architectures can be explored.