Only two of the five models that include dynamic IL-6 levels analyze its effect on bone cell dynamics during the bone remodeling cycle (Table ). IL-6 is included in in their study of the effects of PTH on bone dynamics, albeit in a simplified manner. Following , adapts to include IL-6 in the simulation of intermittent versus continuous PTH treatment. Whereas scales theoretical parameter values so that osteoblast counts remain below 1000 cells, performs a meta-analysis of various experiments to estimate parameter values statistically. This is an improvement over many other bone models that extract experimental values from multiple studies or rely on sparse and disparate clinical data sets.