In pyGlobOpt, we extend the capabilities of our prior ABC algorithm to allow for an asynchronous parallel workflow. Now, we generate and relax structures concurrently as soon as resources become available. The parallelization is controlled by two primary user inputs n @AB DEFGH and n DEFGH AIJ KLHMIN , which determines the number of messages passing interface (MPI) ranks in total and the number of ranks provided to optimize each system. The total number of concurrent systems, n MOMEP is calculated as Eq 6, upon launching the algorithm, n MOMEP structures are created and refined.