In this process, a nanomaterial is coated with an analyte and a library of polymers (Figure ). Next, non-binding polymers are first washed away, and subsequently, higher affinity polymers are removed from the nanomaterial surface, amplified, and used in the next selection round. Over an iteration of multiple rounds (Figure ), it is possible to select highaffinity binders from libraries with up to 10 10 polymers. When comparing the sensor responses of sequences selected in the presence and absence of an analyte, Jeong et al. found that those sequences that were selected in the presence of the analyte exhibited better sensor responses (Figure ).