In this section, we extend our computational analysis to a larger variety of molecular structures to evaluate the validity of the two parameters discussed above, i.e., localization and (pseudo)symmetry of the FMOs, that we propose as controlling photoinduced cyclization in hexatriene-based chromophores. Here we focus attention on the analysis of molecular chromophores experimentally investigated by other groups as molecular photoswitches (Figure ). This section does not aim to provide an exhaustive compilation of previous works, but rather to gather a representative set of systems in order to test our simple orbital rules.