level. In all cases, we found a lower free energy compared to our previous study, by as much as up to -12.9 kcal/mol. The only exception is the n = 10 cluster, where we found a structure 3.6 kcal/mol higher in free energy. Again it should be noted that this is within the error margin of the applied B97-3c method. The (SA) n (DMA) n (n =2-8) clusters have previously been studied by DePalma et al. Again we fully optimized the structures at the B97-3c level to allow a direct comparison. In all cases, we find significantly more stable clusters by up to -27.2 kcal/mol for the (SA) 8 (DMA) 8 cluster. Table in the supporting information shows our improvements for the (SA) n (AM) n (n =6-15) and the (SA) n (DMA) n (n =2-8) systems in detail. This validates that our new approach is significantly more accurate than previously. In the previous study of the SA-AM clusters by Engsvang and Elm, it was found that an ammonium ion was encapsulated in the cluster at the (SA) 7 (AM) 7 cluster size. Here we find that this first occurs for the (SA) 8 (AM) 8 cluster. It should be noted that this difference is caused by the different levels of theory used to obtain the structures (GFN1-xTB and B97-3c). Interestingly, our approach resulted in a (SA) 10 (AM) 10 structure with two encapsulated AM ions, slightly higher in free energy compared to the structure reported previously, which featured a single encapsulated AM ion. This illustrates that while our new sampling approach is significantly more reliable, it is not perfect and care should be taken for systems with many degrees of freedom.