For each PFHxS definition, a breakdown by major categories of annotation content has also been provided (see inset of Figure for the example of EU REACH), including whether literature, use and manufacturing, safety and hazards, toxicity or patent information is available in PubChem, or whether the chemical was added only recently (CID date 2022 or 2023). In total, 598 CIDs are covered under the Stockholm Convention PFHxS definition , 303 with patent, 108 with use, 43 with safety or toxicity, 15 with literature information and 76 recent entries (from 2022 or 2023). The EU REACH definition contains 710 CIDs total, 346 with patent, 113 with use, 44 with safety/toxicity, 25 with literature information and 80 recent CIDs (see Figure ). The section exploring the difference between the definitions contains 112 CIDs in total, of which relatively few have either use, literature or safety/toxicity information (only 14 CIDs total).