In fig. , E min has the second highest AUC at 0.839, followed closely in accuracy by SYBA Score and RA Score. Meanwhile, SA Score is the most accurate with an AUC of 0.89 while SC Score has the lowest AUC of 0.648. Similar synthesizability studies by Gao et al and Voršilák et al 18 also tend to observe SA Score to be highly accurate and SC Score to be less accurate. We note that while E min is not a significantly better synthesizability predictor of compared to other scores, its meaning is straightforward to interpret. This attribute makes E min suitable for quantitative comparisons in addition to qualitative comparisons.