The ongoing decarbonization of electricity grids is limited by the cost and capacity of energy storage. Batteries with higher energy density and operational lifetimes are needed for applications ranging from grid storage to automotive transport. One strategy to improve the stability of Li-ion batteries is to fashion the cathode active material from micron-sized single crystals instead of polycrystalline aggregates. Single crystal layered materials such as LiNi 0.6 Mn 0.2 Co 0.2 O 2 (NMC-622) have demonstrated unprecedented cycling life in laboratory environments, theoretically enabling batteries which could operate for many decades. This is due to the lack of defects and grain boundaries which concentrate stress. Cracks nucleate and propagate from these features, leading to pulverization, lowered capacity, and an increase of internal resistance over time. Intracrystal heterogeneities and fracturing therefore limit the maximum useful cycling rate, the maximum cell voltage, and the stability of the surface. Manufacturing high-performance active materials at scale with controlled crystal quality is challenging. The fabrication of single crys-tal cathode materials typically involves several complex processing steps which must be optimized, including synthesis, annealing, grinding, and coating application. Most of the single crystal materials reported in the academic literature are fabricated at small scale (often without mentioning suppliers) with no straightforward or validated methods to evaluate the quality of the product. For new materials whose durability is measured in decades, it is completely impractical to validate aging through long-term cycling prior to commercial release, and heuristic approaches must therefore be developed which can predict future performance.