CRMP-2 has largely been studied in the context of neurological diseases due to its role in microtubule assembly and axon growth. Indeed, C-terminal truncation of CRMP-2 has been linked to neurodegeneration, and the cleavage site was later localized to S517. As the function of CRMP-2 in lung tissue has only recently begun to be characterized, this novel truncation at C439 may assist in elucidating its role.