Profiling of the six properties of pharmaceutical relevance: MW. LogP, HBD, HBA, TSPA, and RB, revealed that all 11 compound libraries are suitable to be screened in drug discovery campaigns to identify molecules that eventually could be orally administered. It was found that, other than benzene, Nphenyl-benzenesulfonamide, 1H-indol, and N-phenylbenzamide, and 1H-benzimidazol were the most prevalent. The results of the fingerprint-based diversity indicated that SelleckChem is among the most diverse libraries. In contrast, ChemDiv and Asinex are the least diverse, relative to all other data sets.