The adaptive immune system plays a crucial role in safeguarding the body against pathogen-infected and cancerous cells, by recognizing peptides bound to major histocompatibility complex (MHC) molecules on the cell surface . Researchers have gained valuable insights into the immune responses by characterizing the immunopeptidome, which encompasses the repertoire of MHC-bound peptides presented for immunosurveillance. The field of immunopeptidomics has made remarkable advancements in recent years, enabling the identification of T cell targets against tumors, autoimmune diseases, and pathogens .