A library of 1064 phytochemicals were made by downloading drug structures from Pubchem based on available literature. These molecules were tested for the possible anti-chemotherapeutic efficacy in response to selected target hotspot proteins of breast cancer using in-silico docking with the help of Maestro 12.4 version of Schrodinger Suite-2020-1. Molecular Docking study was performed to see the possible efficacy of these compounds for the selected five targets. The crystal structure of 5 potential target proteins: EGFR kinase domain (PDB ID-2J6M), Human estrogen receptor alpha ligand-binding domain (PDB ID-3ERT), FRB fragment of mTOR (PDB ID-4DRH), Progesterone receptor (PDB ID-4OAR), NUDT5 (PDB ID-5NWH) were downloaded from RCSB Protein data bank (RCSB-PDB).