The cyclization of the precursors with aliphatic R 2 and with phenylic R 1 also yielded the desired products 17h-17q in very good yields, showing the robustness of this reaction towards modifications. On the other hand, aliphatic alkynes, bulky isoindolinone alkyne and the methylacetyl alkyne were not tolerated and could not be converted to the desired products 17r-17u under the applied conditions (please see SI for unsucessful experiments).