Figure illustrates the synthesis strategy of micitide 982 (1). The most challenging aspect of the synthesis of micitide 982 (1) lies in the construction of the highly strained atrop-Tyr-Trp linkage composed of three amino acid residues. Recently, we reported the atroposelective total synthesis of cihunamide B. In the total synthesis of cihunamide B, a biaryl linkage was established early in the synthesis, followed by the construction of the highly strained atrop-Trp-Trp linkage through atroposelective Larock macrocyclization towards the end of the synthesis. We believed that this strategy of creating the biaryl linkage early in the synthesis could be applied to the synthesis of the highly strained atrop-Tyr-Trp linkage in micitide 982 (1).