In practice, the value of s is progressively increased from one (in the immediate vicinity of the FG solute) to a maximal value s max (sufficiently far from the solute). The solute itself is entirely described at the FG level (s = 1). Considering the scalings of Eq. ( ) and Table for the force-field parameters, it follows that the bond lengths in the solvent molecule are amplified by s I with no change in the angular geometry. Concerning the interaction parameters α i of solvent atom i (mass m, partial charge q, square-root dispersion coefficient c 6 and square-root repulsion coefficient c 12 ), the scaling is given by