At room temperature, progressive changes in the chemical shift of the well-resolved host proton resonances (H1, H3, H6, H5, see Fig. and SI Section 5) on guest addition reveals binding with a fast exchange regime, in contrast to reports of 1/TIPS-β-CD binding in cyclohexane/benzene which observed slow exchange. Some preference for binding of (S)-1 at room temperature is observable in binding response of H1, consistent with reports in other solvents. Consistent with reports of 1/TIPS-β-CD binding in cyclohexane or benzene, a Job's plot suggests 2:1 host:guest binding (see SI Section 5), however, observing chemical shift changes at multiple host protons, we did not find exclusively monotonic responses, inconsistent with the concerted 2:1 binding model applied elsewhere. Instead, we applied a more orthodox stepwise 2:1 binding model to fit binding (see SI, Section 5), finding increased first and second binding constants for (S)-1 (estimating K11 as 0.22 M and K12 as 2000 M), relative to (R)-1 (estimating K11 as 0.08 M and K12 as 1220 M ). A Rotating Frame Overhauser Effect Spectroscopy (ROESY) NMR spectrum of the (R/S)-1 recognition by and TIPS-β-CD in the same conditions (see SI, Section 5) further demonstrates inclusion, with interactions between the aromatic protons of 1 and cavity protons (H-3 and H-5) of TIPS-β-CD observable.