Bootstrapping with replacement and random subsampling were performed 5000 times for every scenario described above, and the per residue scores obtained from each sample was compared to the top 100 residue scores obtained using all 20 unique replicas with the two correlation metrics: the Spearman's rank, and the Pearson correlation coefficient. The 5000 correlation scores obtained for each scenario were used to construct gaussian kernel density estimates using a bandwidth of 0.02.