The main challenge in ToF-SIMS quantification is the variation of yields for a given ion across different samples solely due to the chemical environment of each sample (i.e. the "matrix effect"). For instance, Figure shows that the normalized count for Ru +which is the count of Ru + ions detected divided by the total count of all detected ionsvaries across the four binary alloys, despite their identical loading of Ru in their mass composition (80 wt.%). The normalized count for Ru is particularly high for Ru-Pt and particularly low for Ru-Pd. The difference in Ru counts is mainly due to such matrix effects. This calls for further data treatment for the dataset to be exploitable.