followed by SILCS/LGFE/TIP3P/GCMC-MD. For this challenge performance was variable with RMSE metric range from 2.43 to 6.64 kcal/mol, while correlation metrics for all methods were relatively poor. Only two methods achieved a coefficient of determination over 0.50. The few methods that achieved high correlation still had low binding free energy accuracy, which was a strong indicator of systematic errors. The FM method had a measure of success with its hybrid approach (MD-based with QM reweighting) method using force-matched PM6-D3H4 parameters for the CB8 guests.