Recent studies leveraging scanning transmission electron microscopy (STEM) instrumentation for nanobeam electron diffraction have illustrated the complex, imperfect substructures of molecular nanocrystal lattices . Our identification of beam-induced reorientation suggests that bends in these lattices can be induced to propagate by electron beam irradiation. Interestingly, an abundance of pre-existing bends does not guarantee beam-induced reorientation, as illustrated by the bend contours we visualized in beam-insensitive Co(II)porphyrin crystals that did not migrate in response to 2 e -/Å 2 of electron beam exposure, but required much higher fluence to move. Instead, we hypothesize that, as incident electrons damage a beam-sensitive nanocrystal, its constituent misoriented domains move with respect to each other, and that the degree to which a crystal experiences reorientation may depend both on its beam-sensitivity and its degree of imperfection.