The BTA9881-derived (BTA) top-children predicted maximal ADV affinities of ~ 0.00001 nM (Figure , red), 3-4-logs higher than those predicted from any of the other drug-parents (Figure Representative F nearby amino acids of selected BTA top-children confirmed the contacts with the 3 α-helix chains of BTA but targeting more amino acids and predicting hydrogen bonds, all of which may explain their higher affinities (Table ). Similar crossdocking of central α-helix cavities were also previously described in other viral trimers, such as those from SARS-CoV2 33 and VHSV, a fish rhabdovirus .