Circular Dichroism (CD) refers to the differential absorption of left-vs. right-circularly polarized light. Since CD spectrum is recorded as a function of wavelength, if a molecule lacks a chromophore or if the absorption occurs outside the relevant wavelength range, it is not possible to detect any CD signal. Thus, CD spectroscopy is usually considered together with UV-vis absorption spectroscopy. CD spectroscopy is particularly valuable in the analysis of self-assembled systems due to its ability to provide insights into the formation dynamics, absolute configurations, molecular conformations, and even molecular interactions. Typically, a CD spectral measurement yields two distinct spectra, as depicted in Figure . In the CD spectrum, the occurrence of a peak or valley is referred to as the Cotton effect. This effect is characterized by a distinct alteration in the circular dichroism around an absorption band (l0) in the UV-vis spectrum, while the chirality of the supramolecular assemblies determines the sign of the CD. Mirror images should be observed if the enantiomers are measured, thus successful determination of the absolute configuration of the system and enantiomeric excess (ee) value, if both the enantiomers are present. From the coordination-driven self-assembly aspect, usually, the ligands consist of aromatic sidewalls, enabling the stereo-specific information of the system to be monitored through CD spectroscopy. For a quantitative understanding, herein we describe two cases, i) chiral induction or resolution by stereospecific interaction between a racemic host and chiral guest, and ii) stereochemical communication.