or MFCC-MBE(2) [Eq. ( )], respectively. In Figure , these errors are plotted as a function of the cutoff λ. The errors in the MFCC protein-ligand interaction energy (for which no cutoff is used) appear as dashed horizontal lines, whereas the errors in the MFCC-MBE protein-ligand interaction energy are shown as solid lines. Note that for λ = 1 Å, all fragment-ligand distances are above this threshold and the results thus coincide with MFCC.