First, as highlighted in the previous section, due to the absence of any key substructures inducing lysosomotropism, the substructures found important by the Fingerprint model might not be specific enough to di↵erentiate between lysosomotropic and non-lysosomotropic compounds. Furthermore, if lysosomotropism is mainly driven by logP and bpKa, then it will hard to find any substructure motifs that drive a logP/bpKa change which in turn modulates lysosomotropism. This is due to the fact the very same (small, because it only considers the neighbors up to two bonds apart) substructure detected by a fingerprint can have very di↵erent logP/bpKa values based on their decoration.