By adapting a general-purpose reactor design disclosed by Sedelmeier for use in our laboratories and using the conditions in Scheme 1, we have had considerable success running lithiation-electrophile trapping sequences in flow across a variety of synthetic and medicinal chemistry projects, enabling access to building blocks whose syntheses are impractical under batch conditions. To date, we have used tee mixers with an internal diameter of 500 μm but these mixers require fast flow rates for effective mixing which is crucial for good conversion. Therefore, material demand is relatively high (at least 5 mmol of each starting material) when 500 μm tee pieces are used (see following section). This can be an obstacle to using flash flow lithiation and trapping chemistry on a small scale because many precursors in a medicinal chemistry program are high value materials that require multi-step syntheses and are only available in small quantities. So, reducing the minimum quantities of material required for lithation-trapping in flow is an attractive proposition. Doing so will enable access to the intermediates required to complete a synthesis from limited amounts of starting material and also allows for more efficient initial investigations of flow conditions for a given substrate.