New and highly interesting compounds are the π-conjugated cage compound 1 (Figure ), its cations up to the hexacation 1 , and related compounds, which were reported by Wu and co-workers and considered to be "3D globally aromatic". This bicyclic macrocycle consists of three equally long -conjugated arms, and in its neutral form was computationally found to possess one Hückel aromatic cycle with 38π-electrons while the lack of aromaticity in the other two cycles is a result of the C2 symmetric structure and poor conjugation in the third bridge. Yet, when the structure of 1 was enforced to D3 symmetry, it was reasoned that the aromaticity involves the complete molecule. The same was found for 1 which has a D3 symmetric global minimum. Since the macrocycle 1 has 56 -electrons, i.e., a 6n + 2 number (n = 9), and exhibits three diatropic ring-currents, it was concluded that 1 is 3Daromatic when D3 symmetric. This also applies to the hexacation which has 50 -electrons, a 6n + 2 number with n = 8. Additionally, Casado and Martín considered 1 and its hexacation 1 in terms of spherical aromaticity, and argued that the hexacation with 50 -electrons follows Hirsch's 2(n + 1) 2 rule for spherical aromaticity with n = 4. However, this rule applies to electron systems that can described as uniformly distributed spherical electron gases for which the wavefunctions are described by the angular momentum number l (l = 0, 1…) and where each energy level is 2l + 1 degenerate. Yet, despite that the -electron counts of 1 and 1 6+ in D3 symmetry are in accord with, respectively, the 6n + 2 and 2(n + 1) 2 rules, this symmetry provides for only double degeneracy. Furthermore, in D3 symmetry 1 and 1 6+ must exhibit three equivalent cyclic paths as their electronic structures must be symmetry-adapted. Earlier, a set of compounds related to 1, the dithiopheno-bridged octaphyrins 2 and 3 (Figure ), were explored by Kim and co-workers. These compounds showed two diatropic ring currents with 26 and 34 -electrons, respectively, a feature that the authors described as dual aromaticity. Yet, the authors also used the term bicycloaromaticity, a concept introduced by Goldstein in 1967 to describe through-space aromatic (homoaromatic) interaction in charged bicyclic macrocycles with puckered structures. Results from 1 H NMR spectroscopy showed that the ring currents of 2 are diatropic, and the aromatic character was further corroborated by Sundholm and co-workers through computations of magnetically induced current densities. Clearly, most molecules are three-dimensional, but the mere combination of a 3D molecular geometry along with (aspects of) aromaticity is not a sufficient condition for 3Daromaticity. As a first example, helicenes are aromatic molecular scaffolds with 3D structures, however, they are not 3D-aromatic. Neither is an octahedral supramolecular scaffold with isolated aromatic compounds. Both are examples of 2D-aromatic systems embedded in 3D scaffolds, i.e., a 3D-aromatic system that cannot be reduced to a set of 2D-aromatic moieties.