Scientists typically use COCONUT to look up individual structures by name or by structure searches. COCONUT's advanced search page allows users to draw a chemical structure in a structure editor and perform a dereplication through an exact match search. One can also perform a substructure or a similarity search. Apart from structure names or structure representations like SMILES, other textual data can be searched in COCONUT. For example, all compounds reported for a given organism or assigned a specific chemical class can be retrieved. Furthermore, all natural products linked to a specific scientific article or other literature references can be queried.