The United Nations has recognized safe sanitation as a universal right 1,2 and set the goal to attain universal coverage of safe sanitation services by 2030. However, the world is not on track to achieve this target. One driving force influencing sanitation coverage is rapid global urbanization coupled with increasing population density in peri-urban areas, urban fringe areas, and informal settlements that lack conventional or safe sanitation infrastructure. Significant challenges exist for extending infrastructure services such as sewer, water, and grid electricity to these areas, which leaves low-resource and vulnerable populations at risk for unsafe sanitation. In 2020 it was reported that the use of onsite sanitation (e.g., septic tanks, improved latrines, decentralized wastewater systems) was just as common as sewered sanitation in these settings (43% population coverage by each). Despite its importance to communities, onsite sanitation is often constructed and operated with limited regulatory oversight and can experience high loadings (i.e., usage) which can overwhelm system capacity -posing a risk to local water resources and public health. Non-sewered sanitation (NSS) systems are prefabricated, integrated treatment units with the potential to meet strict wastewater treatment standards. NSS systems can be used to extend safe sanitation to rural areas where sewered connections are not feasible, in temporary or permanent settlements, and in locations with geographical challenges (e.g., flood-prone, highwater table, isolated areas).