Polymeric materials are ubiquitous in the modern economy due to their broad range of properties and mass production from commodity feedstocks. However, this utility came at the cost of severe scalable chemical recycling technology. Ring-closing depolymerization (RCD) is process which the ceiling temperature (Tc) of a polymeric material is exceeded to favor selective reversion to monomer under thermal or catalytic conditions (Fig. and Fig. ). Many systems which utilize RCD have focused on designing custom monomers with unique structural features to influence ∆Hp and ∆Sp, and hence the Tc. Specifically, these features often include geminal disubstitution, incorporation of bridged or fused ring systems, and increasing transannular strain. In addition to monomer design, careful selection of an appropriate catalyst, solvent, and other reaction parameters can lower the Tc and favor depolymerization. Despite these advances, it remains challenging broadly to assess potential depolymerization ability across numerous polymer classes solely based on monomer structural features-hampering the efforts to use RCD in systems where highly optimized monomer structures have already been developed. While computational and machine-learning models have been developed for predicting the ∆Hp for ring-opening polymerization (ROP) which can help inform the propensity for RCD, we sought to develop a more holistic approach to better understand the complex interrelationships between monomer structural features and reaction parameters in RCD. Here, we developed a computational framework to aid in understanding the effects of solvent-monomer interactions on the kinetic barriers to depolymerization as applied to a variety of aliphatic 6-membered cyclic carbonates. Given the ease of accessibility of highly functionalized 6-membered carbonates from abundant feedstocks and their broad range of applications, understanding the propensity of these systems to undergo controlled RCD will provide needed insight into fundamental reactivity trends. In contrast to cyclic lactones, there is significantly less known on the structural influences in 6membered carbonates over their thermodynamic polymerization parameters (∆Hp, ∆Sp), making it difficult to ascertain a priori the effect of functional group modifications on the Tc, let alone the depolymerization reaction kinetics. Indeed, there are only a handful of reports investigating depolymerization of 6-membered aliphatic polycarbonates or other ring-sizes in general.