In the 21st century, the plague has been reported from Asia, Africa and America as the pathogenic strain is endemic to animal populations and the recent outbreak in Uganda, the Democratic Republic of Congo, China and Madagascar indicates the major health concern . Though plague has a significant disease history, no highly efficient vaccine with long-lasting support has still been developed. Moreover, the recent emergence of antibiotic-resistant strains poses a serious threat to global public health and biodefense , , . All these aspects trigger biotechnological interest among the scientists with an integrated in silico approach to study Y. pestis for new drug synthesis and vaccine development.