To provide both high accuracy, efficiency, and flexibility for complicated multi-component solutions, here we report a first-of-a-kind hybrid approach that encompasses dynamic coupling of an AIMD representation of the solute with a cDFT description of the solution. The approach enables us to model the effect of chemical changes on the mesoscopic densities and vice versa, in which molecules or ions of interest are treated at the DFT level of theory and the rest of the system at the cDFT level of theory. The approach uses an embedding method, where the interactions between the AIMD and cDFT densities are carried out through electrostatic, correlation, cavitation, and dispersion formulas. For electrostatic coupling, there are several ways to implement the coupling between AIMD and cDFT where the electric field from cDFT interacts with the AIMD solute and charge densities. We used an approach modeling the AIMD electronic density as augmented point charges because it was shown to work with the COSMO solvation model, and QM/MM simulations. In a recent study, we simulated the interface between calcite (104) and aqueous electrolytes (RbCl and MgCl 2 ) with this hybrid AIMD/cDFT approach to investigate the driving forces behind cation and anion ordering at this solid-water interface. The results reveal the significance of coupled polarization and ion correlation interactions giving rise to the electric double layer (EDL) structure, demonstrating the efficacy of our hybrid AIMD/cDFT approach for complex system geometries. In the current work, we applied this hybrid model to compute solvation energies for various molecules and ions and compared our results to those obtained from the widely used continuum solvation model, SMD, 8 as well as to experimental data to explore the main interactions that drive the solvation process. With our model, we also examined the impact of the solvent on a prototype S N 2 reaction of the nucleophilic attack of a chloride ion on methyl chloride in solution and analyzed the energy barrier of the reaction pathway, which revealed the nature of the solvent effect on the reaction.