Bioactivity. Finally, we wanted to answer a key question, -if 2-oxabicyclo[2.1.1]hexanes could indeed mimic the orthosubstituted phenyl ring in real-world bioactive compounds? Therefore, we measured the antifungal activity of the marketed fungicides Fluxapyroxad (BASF), Boscalid (BASF) and their saturated analogues 28-31. In strict contrast to medicinal chemistry, the use of racemic mixtures in agrochemistry is common; 23 therefore for the primary validation of the proof-ofconcept, we directly studied the biological activity of the available racemic compounds 28-31 (Scheme 4).