The rapid analysis speed of GlyCombo could enable exciting new directions which have been realised in other MS applications such as proteomics and metabolomics. At an average search time of 7.5 milliseconds per precursor, real-time instrument acquisition methods could be devised which have been demonstrated to improve analytical depth and real-time method optimisation . Additionally, as downloading raw files and mzML conversion took longer than the combinatorial search itself, repository-scale reanalysis could prove a promising alternative, enabling iterative reanalyses for new insights . GlyCombo's ability to search for precursors with mass errors over 5 Da makes it ideal for data-independent glycan analysis, where precursors are isolated within windows up to 48 Da wide, potentially matching hundreds of glycan compositions to a single MS2 spectrum.