It should be noted that neither RI_PEG_LM nor RI_PEG_DL is enough to predict RI on ILbased SP alone without the use of other MD. It means that the selectivity and the retention mechanism for IL-based SP is considerably different from such on polyethylene glycol. Fig. shows the dependence of prediction accuracy on the number of MD when RI_PEG_LM or RI_PEG_DL is used (SEQ_ADD MD selection method, 200 repeats). For both MD in all repeats, these MD are always selected in the first iteration. It is clearly seen that the use of these MD alone does not allow achieving reasonable accuracy and it works well together with other MD.