For the 5EK2 target, the self-docked native ligand yields a heavy-atom RMSD of 1.4 Å for dkoes (with an approximate binding energy of -8.63 kcal/mol) but only 0.41 Å for Vinardo (with an approximate binding energy of 9.31 kcal/mol). The smaller RMSD for Vinardo suggests that 9.31 kcal/mol may be a more reliable estimate among these four calculations. Nevertheless, all natural products listed for the 5XE1 and 5EK2 protein targets in the Table7-8 above appear to exhibit much stronger binding than the native ligands when evaluated by either scoring function.