We evaluate the performance of different optimization environments on a highly branched dendrimer, composed of 657 atoms in total (figure ). We optimized the atom and residue graphs on a random subset of 15 bonds using each optimization environment and global-best particle swarm optimization. We performed 20 parallel optimizations in each case and repeated the entire workflow 20 times, resulting in a total of 400 generated conformations for each combination of graph and environment (figure ).