We find that nucleation starting with iodine oxides can provide cluster formation poten-tials that are more in line with the observed trends in nucleation found by He et al. (2021), compared to nucleation by only iodine oxyacids. It was found that, while the iodine oxide pathway does not reproduce the absolute values, it does reproduce the trend relative to sulfuric acid-ammonia nucleation, at equivalent concentrations, better than the pure iodine oxyacid pathway. The impact of relative humidity on the nucleation rate is found to be relatively small, where the difference between 34% RH and 73% RH is a factor of two in the nucleation rate. Therefore, the primary effect of relative humidity is through the hydrolysis of the iodine oxides, however additional calculations of the hydrates and the hydrolysis rates are needed to be certain of the exact mechanism.