It is worthwhile pointing out that Reaction SPL is really more a (formal) language than a chemical reaction format. Its highly generic data schema permits one to craft "sentences" (SPL documents) that span a virtually unlimited breadth of the types of info they can describe. Other formats may be better, and morecompact, for their specific tasks but Reaction SPL can cover pretty much everything that can be conceived. SPL, based on the very generic model HL7, must be made more specific for, e.g., reactions, which is (at least conceptually) straightforward. In contrast, InChI for example is a very specific model, thus it is more difficult to broaden it to, e.g., general reaction descriptions. Nevertheless, it is useful to compare capabilities of specific formats for reaction handling and representation with the capabilities of Reaction SPL. We provide a tabular overview of this comparison in Table (in the supplementary material ZIP file).