Spodoptera litura polyhedrosis virus (SpltMNPV)'s chitin-binding domain, GP37, efficiently binds purified crab shell chitin . In Herpes simplex virus type 1, the chitin binding domain encoding gene Ha83 is required for budding virus production and inclusion body assembly . To facilitate the production of chitin in Chlorella cells, the Chlorella virus, or Chlorella virus, contains a gene encoding a catalytic chitin synthase . Chitin was found to be strongly adsorbed to tobacco mosaic virus during experiments on infected tobacco plant fibers to determine the virus-releasing enzyme activity of crude mushroom extracts . Also, a concentrated phosphate buffer can release at least some of the adsorbed virus .