Because any computational docking screening method based solely in maximizing affinities, generates highly unspecific molecules by progressively increasing their molecular weights and hydrophobicities , ligand efficiency parameters have been included for filtering traditional screening results. For instance, Ligand Efficiency (LE), Ligand Efficiency Lipophilic Prize (LELP) and many others have been previously proposed . Our previous work already introduced alternative co-evolution with low molecular weight / hydrophobicity criteria during DW-BEL to reduce such trends . Therefore, such criteria have been also employed in the present work for similar purposes.