Extending the kinetic model from SIR to SIRV helps the students to understand the later stages of disease prevention and experience kinetic model selection. Comparing the Rt and Re values help the students to distinguish the second-order reaction and the quasi-first order reaction models for the same reaction mechanism, which echoes what they have learned in the class well. Comparison between the mortgage model, the COVID-19 kinetics, and the conventional chemical reaction kinetics allow the students to compare the units in different systems, especially on the rate constants, thus helping them to understand the purpose of such analysis and the prediction task better. The real-time Rt values correlate with the social events the best thus provides more prediction abilities, but their value is dependent on various conditions such as models, assumptions, data availability, and data accuracy. Overall, applying what they have learned in chemistry classes to a real-world problem motivates the students to learn and practice various skills.