It is well established that PTEN plays a critical function in regulating immune cells' signal transduction . Abnormal PTEN signaling changes the immune system's interaction with the tumor, resulting in immune suppression and tumor escape. PTEN regulates many proteins involved in immune signaling pathways and immune cell growth . PTEN is required for the formation and control of adaptive immune cells. The majority of PTEN's functions are involved in the control of the PI3K signaling pathway. IFN-activates macrophages by downregulating miR-3473b and upregulating phosphatase and tensin homologs . miR-3473b targets PTEN to decrease macrophage activation and inflammation, boosting Akt/glycogen synthase kinase 3 signaling and IL-10 production . This study discovered that the E protein contains a mechanism similar to that of PTEN. This system's involvement with the PI3K signaling pathway also affects the signaling of immune cells, impairing macrophage activation and the inflammatory response.