The solvent-scaling approach offers a number of advantages compared to traditional coarsegraining: (i) the CG parameters are immediately related to those of the FG model (no need to parametrize a distinct CG model); (ii) nearly ideal mixing is expected for CG variants with similar s-values (ideal mixing holding in the limit of identical s-values); (iii) the solvent relaxation timescales should be preserved (no dynamical acceleration typical for coarse-graining ); (iv) the graining level N G can be chosen arbitrarily (and need not be an integer); and (v) in an adaptiveresolution scheme, this level can be varied continuously as a function of the position (without requiring a bundling mechanism), and the variation occurs at a constant number of particles per molecule (no occurrence of fractional degrees of freedom in the buffer layer).