Organofluorine compounds are ubiquitous in our modern world, offering widespread benefits in sectors as diverse as materials, agrochemicals, and pharmaceuticals. For over two centuries, the industrial process of harnessing fluoride from fluorspar has been reliant on the use of H2SO4 to generate large quantities of extremely corrosive and dangerous HF. Recently, mechanochemical methods have been reported to represent an alternative approach for activating CaF2 using K2HPO4 to generate 'Fluoromix' in the solid state which can then be used to synthesize fluorochemicals directly. This novel process bypasses HF, and offers an alternative to the current paradigm for fluoride utilization. Notwithstanding such work, there still exists little fundamental understanding of the nucleophilic reactivity of Ca-F entities at the molecular level (particularly in solution), primarily due to CaF2 having a high lattice energy (∆UL = 2640 kJ mol -1 ) and poor solubility in organic solvents. Such investigations could assist in developing methodologies which exploit the nucleophilicity of molecular fluoride-containing complexes.