To achieve precisely controlled and widely applicable integrated catalytic systems, it is imperative to enrich and update the toolbox available by adding emerging methods for spatial and temporal control. As a complement to artificial catalysis, biocatalysis is also an indispensable, and often provides exquisite selectivity. Thus, the construction of hybrid catalyst systems that involve biocatalysis and artificial spatialtemporally controlled catalysis are exciting new directions for integrated catalysis. Finally, when implementing integrated catalysis, engineering aspects such as reactor design are also crucial to ensure that the anticipated results can be achieved.