While oil-accumulating crops and microbial oil may appear as competing technologies, integrating microbial oil production within an oilcane and oil-sorghum biorefinery may result in impactful synergies. Due to the capital burden of supporting two biofuel pathways, configurations co-producing biodiesel and ethanol may not be market competitive when oilcane has an oil content below 5% (assuming no losses in biomass yield). By converting sugars to microbial oil instead of ethanol, both microbial and vegetative oils can be processed together and converted to biodiesel for better economies of scale. Lastly, the integration of microbial oil also presents opportunities for process intensification in oil recovery from both plant and microbial cells. For example, the high temperature (180°C) and pressure conditions in the liquid hot water pretreatment of bagasse aids the release of up to 70% of the remaining oil within plant cells and can potentially be leveraged to disrupt microbial cells for integrated oil recovery. Taken together, integrating microbial oil production at oilcane biorefineries may result in synergies in plant and microbial oil processing for a more sustainable production process.