• Accumulation of sphingolipids. Ceramides, a common class of sphingolipids, accumulate in aging muscle and reduce its function, impacting the functional capacity of older adults. • Dysregulation of cholesterol metabolism. Senescent cells pile up cholesterol in the lysosomes to support the senescence-associated secretory phenotype (SASP). 109 Furthermore, multiple other common physiological features of aging have been identified and examined in research publications: