It is necessary to demonstrate a potential non-toxic propulsion mechanism capable of directing a multitude of microcarriers towards the cancerous site. It is possible to contemplate two distinct mechanisms for this purpose. As demonstrated before, motile sperms can propel microcarriers in the female reproductive tract without causing any observable tissue damage. Alongside, utilizing a synthetic microcarrier harness containing iron, can be propelled through any desired trajectory by applying an external magnetic field, is a secondary technique. Prior to presenting the magnetic guidance technique, we evaluated sperm motility in the presence of a high concentration of pre-existing cargoes with which the sperms interact, including Psomes, CU(βCD)2, CU(βCD)2-Psomes, HYAL, HYAL-Psomes, MMP-1, and MMPsomes. The normal decrease in motility observed in the sperm solution (TALP) after 6 hours of incubation at 38°C due to energy consumption indicates that these agents do not inhibit sperm motility. In addition, the results demonstrate an increase in sperm motility in the presence of Psomes in MMPsomes and CU(βCD)2-Psomes, indicating that payloads do not impact the propulsion mechanism (Figure ).