and bis(triphenylphosphine)palladium(II) chloride (0.1 eq.) were weighed into a 100 mL flask. THF/H20 (4:1) were then added to the flask. The reaction mixture was carried out under the argon atmosphere at 75 °C for 24 h. After completion of the reaction (observed by TLC), the reaction mixture was cooled to room temperature and then extracted between 2M NaOH (100 mL) and EA (3 × 100 mL). The organic phases were combined, dried over anhydrous Na2SO4, and filtred. The filtrate was concentrated under reduced pressure, and the reaction mixture was purified by flash chromatography using