The workflow highlighted in Section 2 was applied to three case studies of increasing complexity: paracetamol synthesis (Section 3.1), agomelatine synthesis (Section 3.2) and lersivirine synthesis (Section 3.3). With steps 1 to 13 elaborated previously, the final step of the workflow involves ranking the condition-filtered impurity reaction list by maximum relevance and number of hits. Impurities with only one hit were removed, as this was judged to be insufficient justification.