To date, most stimuli-responsive drug delivery systems predominantly focus on enhancing bioavailability and selective cytotoxicity in oncology and improving the delivery of nucleic acids. Few reports exploit a stimuli-responsive system for ondemand or pulsatile delivery . In two reports organic solvents (e.g. ethanol) were employed for preparation of the stimuli-responsive system. Ge et al., for example, synthesized polypyrrole (PPy) nanoparticles by emulsion polymerisation.