The latest studies identified and tested new classes of polymers such as polyester, polycellulose, and fluoropolymer as new candidate materials for a new generation of ECMO membranes. Fluoropolymers such as PTFE and PVDF (or PVDF-co-HFP) demonstrated to be highly promising due to their hydrophobic, oleophobic, and low surface energy properties which inhibit undesirable protein adsorption and prevent the cascade reaction of immune response and blood coagulation . In work, the PVDF-co-HFP membrane coated with Hyflon AD60X (a fluoropolymer with extremely low surface energy) showed competitive performance in terms of blood oxygenation, low protein adsorption, and absence of hemolysis, compared to commercial polyolefin membranes (PMP). However, processing PTFE polymer into a thin, hollow fiber shape is still technically challenging due to its high melt viscosity.