These results indicate the dependency of the activity cliffs with the descriptors used to quantify the similarity between pairs of peptides . For example, if one uses the volume of the accessible surface area instead of the MAP4 fingerprint as a descriptor, then the peptide pairs 2 -5 would no longer be considered activity/property cliffs. Namely, these results indicate that the anti-MRSA activity does not depend uniquely on the peptide sequence and the features encoded on MAP4 fingerprints. The anti-MRSA activity also depends on other criteria, like the tridimensional similarity and the physicochemical properties. We remark that the selection of the molecular representations is a crucial step to decoding correctly the P-SPR.