The time required by the various calculation steps is reported in figure . The time required to assemble the adjoint RHS is negligible with respect to the rest; the next steps, in terms of cost, are the computation of the RHS and of the forces, which also show a perfectly linear scaling regime. Finally, the most expensive steps are the two linear systems; these also show a slightly super-linear scaling regime due to an increasing number of iterations for the largest systems. For the primal linear system of ddCOSMO, the analysis shows that the number of iterations depends on the globularity of the molecule; see [105]. As shown in a few examples in [106, Section 5], biological molecules like proteins and DNA often have a chain-like structure and are thus not globular, and a constant number of iterations can be expected, but with some natural variation as some molecules are more globular than others that explains this performance.