Due to the toxicity of the natural products and analogs thereof following deprotection, the ensuing steps were conducted on a smaller scale. BCl3-mediated deprotection of the Bn and Boc groups proceeded smoothly to deliver (+)-6 (dcSTX) in 77% yield, culminating in a formal total synthesis of numerous STX family members. For instance, slight modification of Kishi's procedure afforded 1 in 80% yield . Of the seven steps used to prepare 1, five form key skeletal bonds resulting in an ideality of 71% .