Briefly, the polymer and drug solutions (prepared in organic solvent) were mixed in desired ratios (the targeted polymer concentration was kept constant at 10 g/L while the drug concentration was increased from 2 to 10 g/L) followed by solvent removal and the subsequent hydration of resultant thin-film by deionized (DI) water. A total of 1260 formulations were prepared with the in-house developed formulation assembly capable to make 24 thin films in one session (Figure ). The (dissolved) drug in the micellar formulation was quantified by HPLC, after removal of (if any) non-solubilized drug by centrifugation. All the HPLC related details i.e. standard curve, elugrams and HPLC method can be found in Figure -S28. The aqueous solubility of pristine drugs was also determined and the results are presented in Table . For the ease of readers and for better comparison, the theoretical compatibility profiles (obtained by Ra calculation) and the practical formulation results are discussed together, individually for each drug with respect to four amphiphilic triblock copolymers. Additionally, the solubility of drugs in formulations is presented in g/L to better compare with the solubility of pristine drugs (determined in-house), however for maximum solubility achieved for each drug, the corresponding loading capacities and loading efficiencies are also presented.