Polarizable force fields have shown some promise in prior SAMPL challenges. In the SAMPL6 host-guest challenge, a method using the AMOEBA force field was employed on CB8 with 14 guests ranging from small organic molecules to larger drug-like compounds, including approved drugs. The initial results had an ME and RMSE of 2.63 and 3.62 kcal/mol respectively, and interestingly, this method was able to correctly identify questionable host-guest complex ratios of CB8 with guests 11 and 12 .