Fig. Unbinding rates or k off (s -1 ) for seven host-guest complexes obtained from experiments, QMrebind-reparameterized force field and the generic force field parameters employed in SEEKR2 simulations. Experimental k off rates for β -cyclodextrin complexed with naphthylethanols were measured using laser flash photolysis . For the other host-guest complexes, the ultrasonic absorption method was employed . The horizontal axis is represented in a logarithmic scale, allowing for better visualization of k off rates that span several orders of magnitude.