Conventional docking of the 1.56 billion Enamine REAL lead-like library was carried out with Schrödinger Glide v9.0 in High-Throughput Virtual Screening (HTVS) mode. Van-der-Waals radii of nonpolar ligand atoms were scaled to 0.8 with a charge-cutoff of 0.15 e (default) and nonplanar amide conformations were penalized in both targets. Additionally, for GAK, the hydrogen-bonding constraint on the hinge-region amide of Cys126 was used. With HTVS mode, the OPLS_2005 forcefield was used, and a single pose per ligand was collected after subjecting 5 poses to post-docking minimization.