We have seen that the difference in affinity between cis and trans conformers among the different systems is the main factor determining the final reaction acceleration using Equation1, this being shown by the nearly perfect exponential correlation between a and the relative probability of finding the 2 cis conformer with respect to the 2 trans conformer in solution and in the different encapsulation complexes (Figure5d). The trend suggests that small incremental stabilizing effects on this conformation, e.g. by changing affinity and size of the co-guest, could result in potentially outstanding enhancements of reactivity for guest 2, keeping all other parameters constant.