LBP is a catalyst that catalyzes the binding of LPS to CD14. The N-terminal region is first combined with LPS to form an LPS monomer LBP complex (similar to the substrate enzyme complex), and then the C-terminal region of LBP and CD14 binds to form the LPS/LBP/CD14 complex. LBP escapes from the complex of 3 molecules and enters the next cycle to create the LPS/CD14 complex . One way is to stimulate monocytes, macrophages, and neutrophils through the LPS/LBP complex receptor (membrane CD14, mCD14) on the cells' membrane to secrete and produce TNF, IL-1, And IL6, and other cytokines, enhancing cell adhesion function and creating inflammation reactions . Another way is soluble CD14 (soluble CD14, sCD14) activates and damages endothelial cells and epithelial cells, and other cells that do not contain mCD14, resulting in a series of biological effects such as inflammation and blood coagulation .