The importance of features of our models investigated via SHAP analysis suggests that a hydrophobic cargo is suited for loading with these micelles if it contains a sufficient amount of polar elements in the form of e.g. hydroxyl groups, ethers or substituted rings, presumably due to interactions with the amide moieties of the polymeric delivery system. These may be established directly through hydrogen bond donor groups or, more indirectly, through bridging water molecules, as it has been shown that these polymeric micelles contain significant amounts of water .