The results of the SAMPL9 host-guest challenge demonstrate that in general binding free energy predictions for WP6 hosts were more accurate compared to bCD and HbCD. We also observe an inexpensive (although not ranked) and simpler approach, based on binding affinity predictions through docking, outperform all methods for WP6. In this section, we will discuss the results and performance of ranked methods, identify the top performing approaches, compare ranked methods where appropriate, and discuss successes and apparent limitations. In addition, we will compare similar methods when appropriate (including non-ranked and reference calculations), and conduct a sensitivity analysis of changes in method protocol to accuracy.