For the exoOAg3 and clip-g1 systems, the automatic pipeline in YANK (while additional simulation options remained the same) was used to determine individual and unique alchemical paths. Ideally, this should improve replica exchange overlap, thus improve sampling. Despite using unique alchemical protocols (with additional lambda windows) for these systems the sampling did not improve and the free energy was not convincingly converged or inaccurate even after simulations up to 30ns per iteration.