These observations leave open the question of the mechanisms by which NO production is increased and even the extent to which that increase can be attributed to surface catalytic reactions. To disentangle the NTP and catalytic contributions to N 2 oxidation, here we report N 2 oxidation experiments at N 2 /O 2 mixing ratios at which NTP-only and Pt-catalyzed NO yields are each vanishingly small. We demonstrate that introduction of a Pt catalyst positioned post-discharge from the N 2 -O 2 radio frequency plasma results in a substantial increase in NO production. To interpret and quantify this evident synergy between NTP and catalyst, we represent the experimental system as a series of coupled reactors to predict NO yields in the absence and presence of a Pt catalyst. We describe the plasma chemistry using a combination of vibrational heating of the diatomics and atomic nitrogen generation and parameterize surface reactions with density-functional-theory (DFT)-computed data. At O 2 mole fractions on the order of 10 The results highlight approaches to exploiting plasma-catalytic chemical synthesis as well as modeling strategies for identifying optimal plasma-catalyst combinations.