We hypothesized the attachment of two glucose units to a glycerol scaffold through the primary alcohols would afford a branched configuration that can effectively attenuate π-stacking interactions, while simultaneously maximizing interactions with GLUT1. Of note, we chose to connect glucose through the anomeric center (as opposed to the C6 position) because this would lock the sugar into its pyranose form to increase the number of alcohols available for hydrogen bonding. Furthermore, modification of the C1 position has been shown to tolerate large cargo without decreasing GLUT1 interaction. We opted to install an azido group to facilitate attachment to alkynylated dyes (or other cargo) via click chemistry. We prepared a panel of three mvGlu-based aza-BODIPY dyes to determine the minimum number of mvGlu units required to inhibit aggregate formation, as well as to evaluate the impact of mvGlu placement (bottom versus top hemispheres of the dye). The chemical structures of the non-glycosylated control AB (AB-OMe2), mvGlu-AB1, mvGlu-AB2, and mvGlu-AB3 are shown in Figure . Synthetic details, including full characterization can be found in the SI.