NB NPs. Will be 4.2 mg TPE-Py and 4.7 mg of α-CD were completely dissolved in 0.5 mL tetrahydrofuran (THF), and then TPE-Py was added to α-CD drop by drop for continuous ultrasound for 10 minutes. After that, 5.2 mg of PTX-NB and 20 mg of DSPE-PEG2000 were completely dissolved in the above solution and then poured into 10 mL of deionized water and sonicated continuously for 10 min. Then stir at room temperature in the fume hood overnight to remove THF from the solution. As a control, other NPs were prepared by assembling PTX, PTX-NB, and TPE-Py⸦ α-CD with DSPE-PEG2000.