Finally, to collect more statistics on the characterized polymer-drug interactions, smaller model systems were built via packmol (~ 5 nm box lengths) and simulated for at least 2 µs. These were modeled with shorter homooligomers (hexamers), as well as drug and water atom densities in accordance with core and shell areas derived from the first replicas of the full micelle after 1.75 µs of simulation. Even though these correspond to conditions during the equilibration phase at elevated temperatures, differences in hydrogen bond autocorrelation functions between repeat units, collected for the whole trajectories, qualitatively agree with findings for larger systems (Figure ). Overall, A blocks showed longer lifetimes for the case of lower drug loadings (Figure ), whereas, within the core, H-bonds formed via pBuOx B blocks showed slower decays compared to systems containing pPrOzi (Figure ). Differences in absolute values can result from the usage of shorter, inherently more flexible hexamers.