Following this, camphanediol and pinanediol, which are natural products either used in the cosmetics industry or the auxiliary ligand for the synthesis of chiral boron compounds, were selected as candidate mechanophores. Both have a "node", as the bridged ring helps to fix the conformation of O-C-C-O dihedral angle. We first conducted a series of EX-AFIR calculations, aiming at providing reliable activation force (F act ) values for camphanediol, pinanediol and their analogues, transand cis-cyclohexanediol. Shown in Figure is the computed ΔG ‡ τ -F τ curves for all the compounds mentioned above, where ΔG ‡ τ is force-coupled free energy barrier of C-C bond homolysis and F τ is force level. Camphanediol was found as the most reactive species under external forces. If the timescale is set to 0.1 second, the computed F act values of camphanediol, pinanediol, ciscyclohexanediol and trans-cyclohexanediol are 1850, 2320, 2970 and 3970 pico-newton, respectively.