The HMG box (IPR009071) is involved in DNA binding and may also be involved in protein-protein interactions. The HMG box (IPR009071) plays a crucial role in regulating DNA-dependent processes such as strand repair, replication, and transcription, all of which require the bending and unwinding of chromatin. Numerous are regulators of gene expression, as well as sequence-dependent and sequence-independent DNA recognition: SOX family of transcription factors; HMG1 and HMG2 non-histone components of chromatin. SSRP, a structural-specific recognition protein, is involved in transcription and replication. MTF1, a mitochondrial transcription factor, and UBF 1/2, a nucleolar transcription factor (upstream binding factor), are both involved in RNA polymerase I transcription. You can connect the HMG box to the sequence of the chondrocyte-specific enhancer of the human type I collagen gene. It can also connect to other SOX genes' binding sites. It also deforms DNA at an angle after binding. HMG-box transcription factors specifically inhibit the expression of target genes by recognizing the T(G/C)AATG(A/G)A sequence. The enhancer region on the Nos2 gene's promoter is capable of binding to HMGXB4.