AD pathology is highly heterogeneous, involving most prominently polymorphic amyloid deposits including senile, cored plaques as well as diffuse plaques . In clinical diagnosis, a binary assessment of highly aggregated amyloid assemblies is typically performed using Congo Red (CR or thioflavin). The advent of a new class of amyloid probes, luminescent conjugated oligothiophenes (LCO), offer conformation specific detection of polymorphic amyloid structures, which revealed age-dependent changes in conformational amyloid polymorphism within individual plaques, conformation specific properties of prions, and, most recently, variability in Aβ aggregate structures between plaques of AD subtypes (e.g. fAD, sAD) .