The omnipresence of the pyridine moiety in natural products, pharmaceuticals, organic materials, and catalysts accentuates its privileged character; examples relevant to this work are shown in Figure . Given this importance, many metal-catalyzed pathways, such as C-H activation, 8 rearrangement, ring-expansion, 10 multicomponent reactions, 11 and molecular editing approaches have been developed for its synthesis. Transition metal-catalyzed intramolecular [2+2+2] annulations by coupling two alkynes with nitriles, which take advantage of using tethered diynes (Scheme 1B) to reduce the entropic penalty have been proven as an effective route to pyridines. Since the pioneering work of Wakatsuki and Yamazaki on CpCo(I)-catalyzed reactions, 15 this cycloaddition has been extensively explored with the aid of various transition metal catalysts, including cobalt, nickel, 17 iron, 18 ruthenium, 19 rhodium, and iridium, 21 in addition to stoichiometric variants using exogenous metal additives. Relevant to this work, the intramolecular cyclization of two different alkynes could be achieved as well by tethering either the two alkynes or one alkyne with the nitrile moiety , thus allowing to control chemoselectivity. Intermolecular transition metal-catalyzed cycloadditions between nitriles and alkynes also represent a straightforward but less explored atom-economical approach for synthesizing multisubstituted pyridines (Figure ). However, following this strategy, only the coupling of two identical alkynes is possible. To the best of our knowledge, the intermolecular coupling between two different alkynes and a nitrile was only accomplished in a stepwise fashion using stoichiometric amounts of Cp2ZrEt2 and NiCl2(PPh3)2 by Takahasi and co-workers 24a or using titanium alkoxide by Sato and co-workers. 24b Thus, a catalytic strategy to realize a three-component cross-annulation of two different alkynes with nitriles would consist of a valuable expansion of the current state of the art, allowing the synthesis of diverse pyridine scaffolds.