The obtained PROTACs were docked at proteins' active site and the PROTAC-protein interactions were calculated via the web server PLIP . According to PLIP study: The control formed 14 hydrophobic bonds, four hydrogen bonds, and one π-cation bond. PROTAC I formed 10 hydrophobic bond, 2 hydrogen bonds, 3 π-cation bond, a halogen bond, and a salt bridge.