Only immunodominant anti-N-terminal and/or anti-repeat Abs were protective in mice models, in contrast to anti-N-terminal or anti-SP Abs Comparison of ~ 200 mAbs induced by circumsporozoite immunization suggested that only those with anti-repeat affinities at low nanoMolar ranges would inhibit malaria infections . Among those mAbs, the mAb850 (targeting N-terminal junction and repeats) induced spiral repeat conformations (conditional-folding?). The picoMolar affinities of mAb850 inhibited P.falciparum in vitro and infection in mice, suggesting new epitopes for vaccine improvements. Anti-TSR Abs are very rare, most probably due to their masking before proteolytic cleavage . The Cterminal shield-like protection and the absence of SP on the surface of circumsporozoites could further explain their low immunogenicity.