The robustness and high site-selectivity showcased suggest it can be used as a precision tool to perform late-stage modifications of biologically-relevant scaffolds (Fig. ). Unactivated alkenes derived from ethyl lactate, methyl paraben, estrone, vitamin-E, phenyl alanine, indomethacine, ibuprofen, oxaprozin were converted into the corresponding β-chloroketones 69-76 (Fog. 4A). In (-)-β-Caryophyllene, featuring both endocyclic and exocyclic double bonds, the acyl radical addition took place selectively at the endocyclic one, affording the chloroketone product 77 as a mixture of diastereomers.