Euclea natalensis roots are rich in naphthoquinone and pentacyclic terpenoid and present 51 ethnomedical uses documented in the literature . Previously, E. natalensis roots were used as a template, resulting in the hydroxyapatite nanoparticles of nearly spherical particles instead of rod-like shapes . Euclea natalensis has the potential to modify the morphology and functionalize the hydroxyapatite nanoparticles, leading to an enhanced drug release system for antimalarial drugs.