Phosphorus is an essential element for life . In biological systems, phosphorus primarily exists in the form of phosphates consist of DNA, RNA, and other biomolecules. Among these biomolecules, adenosine triphosphate (ATP) is especially the fuel of life, taking an important role in cellular processes, such as energy supplying, molecule transporting and so on. In spite of phosphorus, sulfur is also an indispensable element for biological systems. Sulfur is found in certain amino acids, such as cysteine and methionine. In many proteins, disulfide bonds stabilize the three-dimensional conformation of proteins. Additionally, the thioester bond exists in acetyl-CoA which is a molecule that participates in many metabolic processes . The thioester linkage is also a high energy linkage, which is particularly reactive. It has long been speculated that thioesters might have played roles similar to ATP in prebiotic metabolism before phosphorus entered these processes. Computational approach has indicated that a phosphate-indenpendent network might exist in prebiotic metabolism . How phosphate entered the prebiotic metabolism is still a fundamental question in prebiotic metabolism . Given the nucleophilicity of sulfur , sulfur may preferentially react with phosphates to form the P-S bond to introduce phosphate into the reaction network.