In Step 3 of the manufacturing process, the MR84909 solution is acidified with hydrochloric acid solution (9.33 wt%, 1610 kg, 5.35X, 7.00 equiv.) and the resulting aqueous phase containing the MR84909 hydrochloride salt is held at 15-25°C to affect a Boc-deprotection reaction. The mixture is sampled for HPLC analysis to determine the level of residual MR84909 (acceptance criterion not more than 1.0% a/a). Upon achieving a passing IPC result, the mixture is extracted with 2-MeTHF (513 kg, 1.71 X) and the organic phase is separated and discarded. The resulting aqueous phase is adjusted to approximately pH 9 by addition of potassium carbonate solution (30.0 wt%, 1840 kg, 6.12 X).