We assessed the plausibility of structures generated for CRN-E in analogy to the computational benchmarking process with experimental evidence for the detected reaction products. Table shows that the exploration for CRN-E found the the key compounds pertinent to the ozonolysis reactions, namely the ozonide, formaldehyde, methyliumperoxolate, α-hydroxymethylhydroperoxide, and hydrogen peroxide. Chemoton successfully deduced the intermediates of the 1,3-dipolar cycloaddition mechanism summarized in Figure without any human intervention. We note that water, which is essential for the reaction of the alkyliumperoxolate (3 in Figure ), was not included at the start of the exploration but generated by Chemoton. Lastly, water was found to be involved in 59 reactions, thus demonstrating the consistency of the autonomous exploration procedure.