The implementation of the RAIS teaching-learning and evaluation strategy enhances the entrepreneurial skills of students by forming companies that undertake a project to create a product. This approach encourages collaborative and cooperative learning, as well as collective intelligence, by urging students to combine efforts, capacities, and competencies to achieve a collective outcome. RAIS encourages self-managed and autonomous learning to shape individuals who are capable of learning to learn and learning to apply knowledge, equipped to continuously seek new information. Additionally, this strategy motivates students, developing skills and abilities in creativity and innovation that are crucial in the professional realm of chemical engineering and for conducting applied research. This enables a shift from the traditional structure of lectures and written assessments, allowing education in scientific fields at the university to align with the current global trend of education based on inter-and transdisciplinary projects and teams.