Finally, it should be noted that the physical properties included in the training set (densities and enthalpies) are themselves relatively 'cheap' to simulate, requiring only short simulations (on the order of a nanosecond) to converge their ensemble averages. The real advantage of reweighting will likely come when applied to more expensive physical properties, including solvation free energies and binding free energies which take on the order of hours to simulate, but would take only minutes to reweight. The framework is set up to, in the future, be able to support reweighting such properties through the robust workflow engine and flexible plugin architecture.