The bias potential from WTMetaD-IB AL can be used to speed up the free-energy WTMetaD simulation. While this bias potential is not directly proportional to the actual free energy, it serves as a good starting point for WTMetaD. Specifically, the bias generated after the 16 th iteration from WTMetaD-IB AL was used as the initial bias in the WTMetaD simulation, referred to as WTMetaD+inherited bias (WTMetaD+IB) simulation. This accelerated convergence while maintaining the accuracy of WTMetaD started from the unbiased surface (Fig. ). The free energy barrier computed by WTMetaD+IB is 28.4 ± 0.4 kcal mol -1 , which is consistent with standard WTMetaD (Fig. ). However, careful selection of the initial inherited bias is needed to avoid instabilities caused by the accumulation of a large biasing potential, which could push the system toward irrelevant regions of the PES.