The described DW-BEL "non-toxic co-evolutionary docking" results predicted high numbers of TNT children with nanoMolar affinities, new chemotypes, high specificity and conservation of previously defined binding cavities. Because exploration of the vast chemical/chemotype space appear almost endless, further DW-BEL "co-evolutionary docking" criteria may possibly identify more candidates. For instance, it should be also possible to further explore novel artificially-build docking cavities (i.e., preliminary results with poly-benzene de novo ligands), co-evolving with alternative chemical synthesis pathwaypreferences, and/or discarding off-target affinities during co-evolution.