Before we use the KiSSim fingerprints for an all-against-all comparison, we confirmed two important properties: First, the KiSSim fingerprint distances for structures describing the same kinase are significantly lower than for structures describing different kinases (here based on DFG-in structures only). Second, the fingerprint distances for structures in the same DFG conformation are lower than for DFG-in/out structure pairs (here based on spatial features only).