In summary, the Andersson model of water clusters provides a reliable and thermodynamically consistent way to account for the hydrophobic effect of water, that additionally can explain the anomalous properties of pure water.[8] However, it requires access to correctly optimized water clusters and the temperature dependent populations of these structures. BIOVIA COSMOtherm allows to include the hydrophobic effect based on proprietary corrections of hydrogen bond interactions of monomeric water. By doing so, it does not require any further input from the user. The solubility minima are found in most cases with excellent agreement to experiment.