shows here the interest of integrating data from inactive samples in the analysis. By looking only at common annotations in active extracts, rotenoids and fatty acids derivatives are highlighted (Figure B, first TMAP from the left). However, by looking at the specificity of these compounds, we can observe that only the rotenoids are specific to the cluster of active extracts, while fatty acids are spread among a large number of samples and thus less likely to be responsible for the activity (Figure B, second TMAP from the left). It is also possible to spot rotenoids as specific of these active extracts using the CANOPUS chemical class annotations (Figures and). Indeed, these six active extracts present a count of rotenoid annotations superior to 40, while no other sample presents a count superior to 12 (query). The specific presence of these compounds common to most of these six active extracts suggests they are responsible for this activity. In addition, a search of ChEMBL reported anti-T. cruzi, T. brucei, or L.