Further to this, analysis of the time evolution of the aggregate size distributions indicated that, in the reference AA GLYCAM-06j simulations, large disaccharide aggregates formed rapidly (< 50 ns) at the onset of production MD. The size of these large aggregates fluctuated over time to differing extents for each type of disaccharide, with the Glcβ(1→6)Glcβ system exhibiting the lowest volatility in aggregate size. In contrast, a high density of monomers and dimers were observed throughout the entire duration of each CG simulation, consistent across all disaccharide types, as well as in the CHARMM36 simulations. There was no evident trend towards the formation of larger aggregates throughout the time evolution of any CG simulation or CHARMM36 simulation, thus the dearth of large aggregates within the CG simulations is likely not a result of insufficient sampling and is instead indicative of lesser aggregation of disaccharides within both the Martini 2 and Martini 3 force fields compared to the overly aggregated GLYCAM-06j simulation.