The importance of atropisomers has been firmly established. They comprise a meaningful subset of organocatalysts and ligands and possess intriguing properties for materials. However, the prominence of this structural feature in biologically active compounds is perhaps its most important attribute, as a growing number of pharmaceuticals contain axial chirality. Many active research programs rightfully target atroposelective bond-forming methodologies as a result. In contrast, selective crystallization is an established and straightforward protocol for obtaining a single enantiomer or diastereomer. Crystallization is perhaps viewed less favorably than asymmetric synthesis, however, since a reduced yield is implied via at least 50% loss of the undesired epimer. In the case of atropisomers, the desired stereoisomer can be regenerated by effecting rotation about the axis of chirality, where heat is the typical impetus for epimerization. This process of recycling compound is iterative and the diminishing returns of each successive cycle render it tedious. Further, the growing heat-history of the sample tends to cause growth of impurities which can be difficult to purge. MRTX1719 (1a) is an emerging oncology therapy. It contains an axis of chirality about the bond linking the pyrazole and benzene rings (Figure ). Despite the dense functionalization surrounding the biaryl bond, the barrier to rotation is only 28.9 kcal/mol, equating to a half-life of 1 hr at 80 °C. Attempts to develop a stereoselective biaryl coupling were complicated by the nonnegligible rate of rotation about the bond which occur at the reaction temperature. Even if the coupling were selective, the compound would undergo epimerization simultaneously. Moreover, axially chiral benzonitriles are known to be particularly challenging substrates. Fortunately, a late-stage stereoselective crystallization was developed but a serious drawback was low yield (37%) at the end of the synthesis. Perhaps one might consider a dynamic kinetic resolution to solve this issue. In the scenario where one stereoisomer is selectively insoluble, one could first conduct a crystallization, and then renew the population of the depleted rotamer via epimerization. Further crystallization would drive the equilibrium to completion. Unfortunately, the conditions associated with crystallization (lowtemperature) and epimerization (high-temperature) are inherently at odds.