The conformational properties of aqueous alanine dipeptide in the AdSoS scheme under spherical geometry can be compared to the FG reference based on the Ramachandran map of the backbone φ and ψ torsional angles (Fig. ). The three simulation schemes are in excellent agreement, which suggests that the conformational properties of the solute are adequately captured in the Ad-SoS setup. Note that transitions to the left-handed helix were never observed within the 100 ns simulation times for all setups. A much longer simulation time might be necessary to cross this barrier. 117 shown in the margins. The CG system (orange) refers to s max = 2.0 and R c = 2.4 nm. The CG+B system (green) has the same parameters as the CG system with the additional correction potential.