CoFe2O4 was found to be inactive in the oxidation of 2-butanol: no MEK was found in the liquid products, and no appreciable decrease in the concentration of 2-butanol was detected. Moreover, no CO2 was detected in the gas phase. When testing ZnCo2O4 and NiCo2O4, very small amounts of MEK (corresponding to 0.3% and 0.5% yields respectively) were detected in the liquid products for the entire duration of the catalytic tests. At the same time, a non-negligible decrease in the concentration of 2-butanol was observed, and CO2 was detected in the gas phase. On the other hand, MnCo2O4 proved to be the best among all tested catalysts, reaching up to 15% yield to MEK, and outclassing Co3O4 by far. Comparing the conversion of 2-butanol and the concentration of CO2 in the gas-phase with those observed for Co3O4, it appears that MnCo2O4 is superior to Co3O4 also in terms of selectivity to MEK. The catalytic performances of MnCo2O4 proved to be stable during the seven days of catalytic testing.