To overcome the remaining crystallinity of IND within the polymer matrix, the DSC measurements showed that simply remelting the extrudates resolved this issue. Apart from the amorphous character, a second parameter is critical to facilitate rapid dissolution -a high surface area. For this, highly porous microfiber meshes consisting of small diameter fibers offer a higher surface area compared to solid films and should be ideal for an accelerated drug release. As mentioned before, MEW has been chosen here to fabricate such controlled microfibrous scaffolds without the use of toxic solvents.