When such discrepancies arise, a common practice is to adjust weights of conformations generated from simulations to align with experimental observations. The reweighted ensemble is then utilized to make more accurate predictions. Several strategies 10, have been proposed for ensemble reweighting. One common philosophy behind these strategies is to make the reweighted ensemble as close to the original ensemble as possible while matching experimental data. Ensemble reweighting effectively combines information from simulations and experiments, offering a conservative approach to improve predictions for specific systems that have experimental data. However, it's important to note that the improvement in predicting accuracy achieved through this process is tailored to individual systems and does not transfer to other systems.