Cyclohexanone oxime is an important feedstock in the nitrogen industry as it can undergo Beckmann rearrangement to make caprolactam, the monomeric unit of Nylon-6. With the annual global market of Nylon-6 anticipated to be as high as 8.9 million tons by 2024, the production capacity of cyclohexanone oxime should also be expanded accordingly. To date, the majority of cyclohexanone oxime is produced by the nucleophilic addition-elimination reaction between cyclohexanone and hydroxylamine (NH2OH), which is typically generated via hydrogenation of NOx on palladium catalysts or oxidation of ammonia (NH3) by O2/H2O2 (Figure ). However, these chemical processes generally require harsh reaction conditions (e.g. high temperatures and/or pressures, strong acidic/alkaline solutions), and therefore are challenged by a series of environmental and safety concerns. More specifically, the hydrogenation route is limited by the requirements of pressurized H2 gas, strong acidic conditions, as well as precious metal catalysts. Moreover, transportation and storage of concentrated NH2OH also faces challenges, including the risk of explosion. On the other hand, NH3 oxidation utilizes NH2OH generated in-situ as needed. Yet, this synthetic route still demands elevated temperatures, high pH, and an excess of H2O2 as oxidant, which also has transportation and storage issues. Hence, there is a strong desire for an alternative strategy to produce cyclohexanone oxime under mild conditions.