On average, the PLIFs generated from DiffDock-L poses were less similar to those derived from the measured protein-ligand complexes than the PLIFs generated from Vina poses (Table ). Vina produced at least one pose with high PLIF similarity to one or more measured protein-ligand complexes for 29.75% of the active compounds (of each target), while for DiffDock-L, this value was 21.90%. A PLIF similarity of 1.00 was observed with Vina and DiffDock-L for 7.28% and 4.99% of the active compounds, respectively.