It is inherent to the template-based approach that novel chemistries are not able to be predicted, as the precedent arises from extraction of a specific sub-graph from the underlying dataset. Therefore, the model learns to predict existing chemistry exhibiting a similar sub-graph to the queried compound. 'Ring Breaker' is capable of predicting and suggesting ideas for the synthesis of unprecedented ring systems. For each prediction, the patent id or Reaxys id corresponding to the template used has been given as a precedent. In all cases the probability 'p(x)' of predicting the template for the given compound has been shown, where 'x' refers to the predictions rank i.e. 'p(1) = 0.983' means the first prediction with an associated probability of 0.983. In cases where the precursors have been highlighted in a box, the predicted disconnection matches that reported in the literature. c) shows one of the reactions that are precedented for a benzene ring system, however is applied in a different context, on the pyridine. The N atom of the pyridine is outside of the templates scope and so the template can be applied in this context in silico.