Consider first the case of SM36 in figure . In water, the local density in the first solvation shell around the solute sulfone S, sulfoxide (ring) S, and amine N are all greater than bulk, with the largest density around the sulfoxide S. As a solvent, dimethyl sulfoxide (DMSO) is well known for its strong hydrogen bond accepting ability, so this result is not surprising. Consider next the case of neat 1-octanol. The local density in the first solvation shell around the solute sulfone S, sulfoxide (ring) S, and amine N are again all greater than bulk. Here the largest density is around N, followed by the sulfoxide S and then the sulfone S. With the addition of water, in water-saturated 1-octanol the change in local density around N is insignificant, however, we notice a large change in local density around the sulfoxide and solfone S, with the sulfoxide having the largest increase. We also point out the larger width of the peak around the sulfoxide S, which is indicative of the larger population of solvent O. We therefore find that the presence of water increases the local density of solvent O around the solute sulfone and sulfoxide S.