A recent study demonstrated the potential of a bi-functional compound containing the small molecule (+)-JQ1 warhead to induce the nuclear localization of cytoplasmic proteins. 14 (+)-JQ1 is a widely studied potent binder for members of the BET bromodomain family of proteins. 15 While most of these proteins have primary roles in the nucleus , they can perform secondary functions in the cytoplasm, especially in the context of cellular signalling and stress responses. Thus, BET bromodomain proteins display an intermediary shuttling state between the nucleus and cytoplasm.