Cabezudo and co-workers have proposed the scaling-down of protein-water interactions to stabilize Martini 3 TM peptide states . The fact that they successfully employed this strategy reinforces that, indeed, a hydrophobcity/hydrophilicity imbalance is at play. The same strategy can, in principle, be applied to the coiled coil dimer systems: weakening protein-water interactions would certainly drive a stronger dimerization. It is unclear, however, whether a blanket scaling would be able to correct the apparent rejection of hydrophobic contacts seen in Figure .