Such manual approaches are becoming increasingly unsustainable, especially in light of recent advances in miniaturization and robotics which have enabled the intensive, high-throughput screening of enzymes and process conditions. Such technological advances foster the discovery of novel enzymatic systems and the (retro-)synthetic design of enzyme-catalyzed reaction cascades through integration of systematic data acquisition, data analysis, and simulation. In a fully digitalised biocatalytic laboratory, an electronic lab notebook supports researchers at the bench to plan experiments and to collect experimental data and metadata, all laboratory devices are connected by a common standard, various modelling and data analysis tools are combined to analyze the data , , and the results are uploaded to searchable repositories without manual intervention .