Another future challenge is the description of the interfaces. The exchange of molecules between the different regions is governed by the structural and dynamic properties of the interfaces, which critically depend on the conformational ensembles of the involved biological macromolecules, and also on their radial and orientational distributions at the boundaries . von Bülow et al. showed that the chain expansion of IDPs at the interface is in between that of the bulk dilute and bulk dense phase . Furthermore, the orientation profiles of the IDPs across the interface show a general trend towards preferential orientation of the IDPs at the interface, with some variations. Interestingly, a strong thermodynamic driving force for PS is correlated with pronounced orientational ordering. Such studies could be extended towards multilayered multiphasic condensates to investigate the link between PS tendency, interface structure, and also the partitioning of small molecules . Furthermore, biomolecular condensates can have interphase electric potentials . Accurate modeling of the interfaces would require extensive sampling and models with accurate long-range electrostatics, possibly opening the way towards electrochemistry applications .