Figure . Regulation of deadenylation by the NOT9 subunit of the CCR4-NOT complex. The NOT9 subunit can either be bound to RBPs that recruit their specific subsets of mRNA for deadenylation or bind mRNA directly in a non-specific manner. The helical domain used by one of these RBPs to bind NOT9 was converted into a stapled peptide inhibitor that was able to inhibit both protein-protein and protein-RNA interactions simultaneously and impair the activity of the CCR4-NOT complex.