Leveraging the scaffold-level ensemble statistics allows for the incorporation of progressibility information directly into the selection of individual molecules in a fragment screening library, where nEVPS serves as a simple and interpretable proxy for progressibility. Ideally, progressible fragments should exhibit the highest possible nEVPS and a high nEXIT, with the latter indicating a greater potential for substitutions and compound decorations to establish SAR around a scaffold. Additionally, a higher %Exploited is preferable, as shown in the context of Figure .