Rate constants were obtained from different methods, i.e., the brute force calculations, WE, GaMD-WE, and the DeepWEST method for transitions between metastable regions of interest (Table ). For the transitions between the central metastable region, α R to P II , the DeepWEST method outperformed both the WE and the GaMD-WE methods in estimating the rate constant. The rate constant for the DeepWEST method converged faster compared to the brute force value (Figure ). However, as observed in Figure , all the methods slightly overestimated the rate constant for the transition from P II to α R . In the transitions from α L to P II (Figure ), P II to α L (Figure ), α R to α L (Figure ), and α L to α R (Figure ), comparable convergence and accuracy of the kinetic rates were observed for the DeepWEST approach as compared to the WE and the GaMD-WE methods.