Veber's rules , GlaxoSmithKline's (GSK) 4/400 rule and Pfizer 3/75 rule (Table ). Having physicochemical properties in the limits of either Lipinski's, Veber's or GSK rules is usually related with a good NPs contain complex structures and are large and diverse, therefore, compared with synthetic drugs, it is not easy that they satisfy most of the criteria of Lipinski's Ro5 or the other drug-likeness parameters mentioned above. Nevertheless, it is shown in the violin plots that a broad range of the LaNaPDB compounds satisfy most of the rules of thumb of Table for the physicochemical properties of pharmaceutical interest.