In the presence of catalytic amounts of piperidine and refluxing ethanol, the reaction of compound 4 with 1,3-diphenylpropane-1,3-dione (5) produced the condensed product 1,6dihydro-1-(5-methylthiazol-2-yl)-2-phenyl-4-styrylpyridin-3-yl)(phenyl)methanone derivative . A nitrile absorption band at 2250 cm -1 and two potent carbonyl bands at 1681 and 1660 cm -1 were visible in the infrared spectra of compound 7. As well as an aromatic multiple signal at δ 7.23-8.19 caused by phenyl ring and vinyl protons, were detected in the 1 H NMR spectra of compound 7. Additionally, a molecular ion peak at m/z (%) 499.26 (13.23) was visible in the mass spectrum associated with the substance. Additionally, while refluxing ethanol with a catalytic quantity of piperidine, the cyanoacetamide derivative 1 and furan-2-carbaldehyde (8) combine to form the (E)-2-cyano-3-(furan-2-yl)-N-(5-methylthiazol-2-yl)acrylamide (9) (Scheme 1). The IR spectra of the latter product showed two absorption bands near 2218 and 1624 cm -1 , respectively, induced by the nitrile and carbonyl groups, as well as an absorption band at 3406 cm -1 caused by the NH group. Additionally, a peak in the mass spectrum at m/z 259.20 (25.39) coincided with the molecular ion. Additionally, this investigation expanded to look into the sensitivity of compound 1 to nitrogennucleophilic reagents. Thus, only one isolable product, 6-amino-1,2-dihydro-1-(5-methylthiazol-2-yl)pyrazolo[5,1-c][1,2,4]triazole-3-thione (13), was produced when compound 1 interacted with an equimolar quantity of thiocarbohydrazide (10) in refluxing ethanol (Scheme 2). The thiocarbohydrazide (10) was simply added to the CN group in compound 1 to produce the intermediate 11, which was then followed by the elimination of water to produce the intermediate 12. This was then converted into compound 13 by the loss of ammonia. Compound 13's IR spectra showed two absorption bands at 3457 and 3272 cm -1 , which are typical of the NH2 group, and one absorption band at 3205 cm -1 , which is typical of the NH function. Two D2O-exchangeable signals for NH2 and NH protons were visible in compound 13's 1 H NMR spectrum at δ 3.98 and 8.67, respectively. Additionally, a molecular ion peak was visible in the mass spectrum of the substance at m/z (%) 252.58 (28.00). The reaction between Nbromosuccinimide (NBS) and the cyanoacetamide derivative 1, in the presence of ammonium acetate, produces 2-bromo-2-cyano-N-(5-methylthiazol-2-yl)acetamide as the end product. The IR spectrum of the isolated product 14 indicates the presence of three bands of absorption near 3400, 2268, and 1698 cm -1 that are diagnostic for the NH, nitrile, and carbonyl functions, respectively. Additionally, according to its 1 H NMR spectra, a singlet signal at δ 3.31 due to a CH-Br proton is displayed as well as its mass spectrum demonstrated a peak for a molecular ion at m/z 260.41 (22.01%), Scheme 2.