Before variant bioactivity analysis, the Papyrus and ChEMBL datasets were integrated. Firstly, only the Papyrus entries originating from the Christmann subset were considered, filtering out de facto any Papyrus data point with ChEMBL as a source, avoiding duplicates. ChEMBL compounds were given Papyrus-like identifiers (connectivity). Then, the average pchembl_value was calculated for unique target_id-connectivity pairs. For data points with no pchembl_value, the most common activity label was kept. Finally, the VEBD for analysis was constrained to only targets with at least one variant annotated other than the WT.