For instance, the RMSD values reported for the G2S model, which was trained on E2 and SN2 reaction data from the QMrxn20 database, are not directly comparable to those of OA-ReactDiff, which was trained on the Transition1x dataset. The differences in dataset size and molecular diversity make such comparisons unreliable. Furthermore, inconsistency in training strategies further complicates comparisons. For example, one version of TSNet 121 underwent pre-training on the QM9 dataset before being fine-tuned on a small dataset of SN2 reactions, while another version was trained from scratch using the Isomerisation dataset.