The measurable exposome chemical space is the subspace of chemicals that can be measured via existing analytical strategies, in particular GC and/or LC-HRMS. A recent review by Manz et al., hightlighted that the majority of human exposome-related studies that employed HRMS-based NTA used LC-MS only (51%), followed then by GC-MS only (32%), ≈16% used both techniques together and 1% used direct injection-HRMS without any separation. Of 76 HRMS-based studies reviewed in total, there was no consistency in application of different analytical platforms across chemical classes or the environmental compartment studied.