PNT (PS51433) is a PNT (or pointed tip) domain that is highly conserved and is present in Ets transcription factors, such as mammalian Ets-1, Ets-2, Erg, Fli-1, GABPalpha, and Tel, as well as Drosophila Pnt-P2 and Yan). Protein-protein binding is the function of the PNT domain. The ETS family is responsible for a variety of functions, such as the regulation of cell differentiation, cell cycle regulation, cell migration, cell proliferation, apoptosis, and angiogenesis. Studies have linked numerous ETS to cancer, including cases of gene fusion. For instance, Ewing's sarcoma is the result of the ERG (ETS Related Gene) transcription factor fusing with the EWS gene.