Variation of all possible interactions among RNA-protein condensate constituents (RNA-RNA, RNAprotein, protein-protein) will also result in changes in physical and structural condensate properties. For example, phase separation may be prevented by exclusion of multivalency in RNA structures, which results in weaker protein-RNA interactions, resulting in RNP droplets becoming more fluid. On the other hand, abnormal accumulation of RNAs in the nucleus or cytoplasm as a result of aberrant LLPS might result in plaque formation and eventually lead to neurodegenerative diseases. Timely disaggregation of these proteins and associated RNAs is thus essential to prevent and/or treat such diseases. There are some natural intracellular methods present to avoid these situations and prevent aberrant cellular RNA accumulation, such as nuclear import receptors, which chaperone RBPs, preventing phase separation. Parallel therapeutic approaches to prevent aberrant cellular RNA accumulation includes addition of high concentrations of RNA, which prevents aberrant RBP LLPS by promoting strictly bimolecular RNA-RBP interactions (which inhibits phase separation) while inhibiting multivalent RNA-RBP interaction networks stretching across multiple components (which generally promotes phase separation). Although RNA participation in cellular LLPS has been well investigated, an integrative repository of these RNAs is currently lacking. For example, each disordered RBP has its own compendium of RNA binding specificities, but it is unknown both how RNA folding affects phase separation of RBPs and how multiple areas of structural complexity may combinatorially affect RNA structure and subsequent condensation. The role of subcompartmentalization or biphasic RNA droplets, which has been shown in vitro, also remains unknown. To fill these gaps, one tool that could be used are RNA databases, such as RPS, which reports RNA related to cellular phase separation. However, as RPS only focuses on 20 specific condensates, further expansion of such databases is necessary.