In addition to physical validity, we aimed to understand how closely the generated docking poses resemble the protein-ligand interaction patterns observed in measured structural data. To achieve this, we compiled an extensive set of 2501 protein-ligand complexes for the 43 targets of interest from the PDB (see Methods for details and Figure for the number of protein-ligand complexes collected for each target). We subsequently generated the PLIFs for all these measured protein-ligand complexes and those created through docking (see Methods for details). This process allowed us to compare the PLIFs derived from both measured and generated protein-ligand complexes.