The guests proposed in SAMPL7 have been reported to bind native -CD, mono-3-carboxyproponamido--CD, and -CD substituted with an amine at the 3 position (secondary face). Rimantadine (Figure ) binds beta-CD and mono-3-carboxyproponamido-CD with its cationic ammonium group projecting out from the secondary face . On the other hand rimantadine prefers the primary orientation when binding -CD with an amine at the 3 position. Both 4-methyl-cyclohexanol (g1) and rimantadine (g2) (Figure ) may bind to the new -CD derivative hosts (MGLab9 through MGLab36 Figure ) in either of the three orientations.