Based on reports demonstrating higher levels of P2Y12R positive microglia in Trem2 -/-mice, we anticipated a higher tracer uptake due to increased target expression in these mice. TACs from dynamic PET imaging in Trem2 -/-mice (n = 8) revealed the lowest tracer uptake in comparison to WT and microglia-depleted mice during the initial phase, whereas the later plateau phase was characterised by elevated tracer retention in the Trem2 -/-mouse model compared to PLX mice. This effect is significant 25 -60 min p.i. (30% higher accumulation in Trem2 -/-, p = 0.0362). However, no significant difference was observed comparing WT and Trem2 -/-mice.