In general, it is now evident that, such morphology transition is usually driven by presence of certain level of hydrophobic environment in the whole system assembling together, which in the case of A-pBuOx-A triblock copolymer is provided by a specific threshold drug concentration while in the case of A-pPentOx-A triblock copolymer, the hydrophobicity of pPentOx block is sufficient to induce this transition which is further substantiated with the drug addition leading to rapid formulation agglomeration. The direct comparison of A-pBuOx-A and A-pPentOx-A micellar formulations utilizing the analytical tools like solid state NMR and SANS can give us much deeper understanding of polymer drug interactions resulting in specialized micellar architecture, however such analysis is beyond the scope of current contribution.