However, unlike the MOD1 combination, there is no increase in the proportion of lassoed conformations (14.6% vs. 3.7%). This combination of auxiliary and thioester promotes the most pronounced increase in the pre-tadpole set (3.5% to 6.5%). To understand the reason for increased pre-cyclic structures observed for MOD1, a cluster analysis was performed again with the DBSCAN algorithm and identified the most probable conformations in pre-lasso (Figures and) and pre-tadpole (Figures regions.