All the selected chalcones exhibit drug-like physicochemical properties according to results in tables 4.1, having a molecular weight (MW) of less than 600 gmol -, less than 12 hydrogen bond acceptors (nHA), and less than 7 hydrogen bond donor (nHD). The designed chalcones had ess than 6 rings (nRing), fewer than 11 rotatable bonds (nRot), and less than 15 heteroatoms (nHet) .