As already noted in the Methodology Section, the trends described above are also recovered when electrostatic parameters derived from polarizable (AMOEBA) force field calculations are used to compute the electric fields (cf. Section S2 of the Supporting Information). Local distortions in the magnitude of the OLEFs are observed for some of the evaluation points directly adjacent to the atoms of the protein matrix, but most quivers are only slightly modulated; e.g., along the Fe2-Fe6 axis, the discrepancy in electric field magnitude between both descriptions amounts to a mere 10%. These findings underscore the robustness of our findings discussed above.