However, to the best of our knowledge, none of these systems was investigated with respect to GBM treatment. Interestingly though, polysorbate 80 coated, ATV-loaded poly(lactic-co-glycolic acid)-b-PEG (PLGA-PEG) nanoparticles have been designed to investigate the influence of the coating on the transport of ATV to the brain. Important to note, both -coated and uncoated nanoparticles -were able to penetrate the BBB in vivo reaching maximum brain-concentration 1 h post-intravenous injection. Pioneering work by Kabanov and co-workers revealed that several amphiphilic polymers can facilitate transport of small molecules and proteins across the BBB.