In spite of reaction acceleration driven by microdroplet chemistry, low product amount in microdroplets limits its application in organic and industrial synthesis. At present, three strategies have been adopted to scale up microdroplet reaction, namely, array sprayers, high flux and solvent recycling. In this experiment, high flux strategy was used to scale up the synthesis of vicinal diamine 1a in microdroplets due to its simplicity. The amount of vicinal diamine 2a was amplified by increasing the concentration of substrate 1a