In the next set of simulations, we created a box with reflective walls using hard potentials and a binary mixture of Lennard-Jones particles. With this design, we eliminated the wall-particle attractive forces, and therefore, the energy effect from the walls on the distribution of particles. Now, both types of particles energetically tend to attract each other in the box, but entropically prefer to locate close to the wall. When particles are of the same size, the ones that have relatively high attractive forces form clusters, and the others with lower attractive forces, within the time frame of our simulation, distribute evenly in the box (Fig. and Supporting Information, Fig. ). To detect the entropy effect, we designed a binary mixture of particles with the same attractive forces, but significantly different in volume. We found that the population of larger particles in regions adjacent to the walls is substantial as this accompanies an increase of the entropy (Fig. and Supporting Information, Fig. ). Fig. implies that the entropic force that emerges from the depletion effect attracts particles toward the wall outcompete the energy effect that is the cause of particles aggregation in the box. We observe that the particles with low particleparticle attractive forces have a high tendency toward the wall owing to entropic forces. We found that, when we used single-type particles with high attractive forces, the energy effect outcompetes the entropy effect in the formation of clusters. On the other hand, particles with low attractive forces, in a one-component system, preferably accumulate adjacent to the wall. These results indicate that the entropy effect outcompetes the energy effect in favoring particles to a position adjacent to the wall in a weakly associating system. The simulations with hard spheres and Lennard-Jones wall also led to an accumulation of particles especially larger ones next to the wall (Supporting Information, Figs. and)