At the same time the elements cobalt, ruthenium, silver, europium, iridium and platinum are well represented in both datasets. While this can partly be explained by the high submission rates for compounds containing some of these elements, it perhaps suggests a trend in the activity patterns of metal-containing compounds. Increasing the number of tested metal complexes will be the only way to further support or contradict this finding. These 21 complexes were tested against an extended panel of eight Candida and Cryptococcus strains. We used the same panel for the extended testing of a series of cobalt complexes (including Co1) in an earlier study. The panel comprises strains with different resistance profiles, including clinical isolates which are resistant to multiple classes of antifungal drugs. We also repeated the cytotoxicity and haemolysis assays with the new batch of compounds to verify earlier results and measure any possible adverse effects at higher concentrations (up to at least 100 µM).