The highest accuracy values were obtained by eight models with the maximum F1 value: SVM5, SVM6, SVM13, SVM14, SVM21, SVM22, SVM29, and SCM30. The eight models share the same kernel type, rbf, but different "class weight" and descriptors. Four models were trained with ECFP4 and four with ECFP6. SVM21 and SVM22 (trained withECFP6) had the highest precision values, with maximum accuracy values. In contrast, SVM13 trained with ECFP4 had the maximum recall value. These results suggest that for the PPI inhibitors used in this work, ECFP4 is better to train models with high precision and ECFP6 is more appropriate to train models with high recall values.