Any QSRR study requires a large enough data set of retention values (retention time (RT) or RI) of diverse compounds, and the diversity of data sets affects the results . To the best of our knowledge, such data sets are not available for IL-based SP. For each of SP, the data about the retention are available for a very small number of compounds. Usually these are data about test mixtures for determination of polarity or solvent parameters, or data about several very similar compounds. To the best of our knowledge, there are very few works about the RI prediction and QSRR for IL-based SP, and all of them are focused on one specific class of chemical compounds. In Ref. , QSRR for polychlorinated biphenyls and IL-based SP are considered. There are also some works that predict the chromatographic properties of IL based on their structure, rather than predict the retention for a given IL based on the structure of the analyte. We focus on the latter task: to predict the retention of diverse compounds on a given IL-based SP.