The difference between the sets of ASDs at different drug loading can be largely explained by the differences in the solid-state form of the drug. At 50wt% drug loading, all ASDs are fully amorphous, whereas at 80wt% drug loading, a significant amount of residual crystalline drug is present. As amorphous IND has a higher aqueous solubility and consequently dissolution rate compared to its crystalline form, due to its higher free energy , the corresponding fully amorphous ASDs show faster dissolution compared to the partially crystalline ones. An additional factor likely contributing to the higher drug release at 50wt% drug loading, is the larger influence of the highly soluble polymer at the 50wt% compared to 80wt% drug loading.