Nonetheless, NGT has limitations. It's performance relies on the underlying CSL quality and representativeness. Biases in the CSL could be reflected in the generated compounds, potentially limiting the exploration of diverse chemical spaces. Using comprehensive and unbiased CSLs remains crucial. Further, the current exploration/exploitation balance might not be optimal for all scenarios. Depending on the target and available data, focusing more on diverse exploration for initial hit discovery or targeted exploitation for lead optimization might be desired. Related, our current implementation focused on constraint satisfiability whereas some scenarios may require optimization of one or several endpoints. Despite these limitations, NGT represents a significant step forward in utilizing ultra-large CSLs for hit discovery with guarantees of synthesizability.