The kinase inhibitor SRF is used for the treatment of renal and hepatocellular carcinoma . It is practically insoluble in plain water (Table ). According to Ra, the hydrophilic pMeOx should exhibit a higher compatibility with SRF than hydrophobic blocks. For the hydrophobic blocks, the order of compatibility was found to be pBuOx > pPrOzi > pPentOx > pBuOzi (Figure ). On the contrary, the formulation results showed that the best solubilizer for SRF is A-pPrOzi-A giving a solubility of 5.6 g/L at 8 g/L SRF feed (LC ≈ 36 wt.% and LE ≈ 70%) (Figure ). A-pBuOzi-A, the higher homologue of A-pPrOzi-A appeared to be least efficient solubilizer for SRF and solubility fell below 0.7 g/L at all the employed feed of SRF. The A-pPentOx-A appeared to be the second best solubilizer (4.1 g/L) while A-pBuOx-A, being best solubilizer for paclitaxel and many other drug herein, could solubilize SRF only to 1.6 g/L Overall, no correlation was observed between the estimated compatibility and formulation results.