To enable these large-scale CpHMD simulations, we first generated CpHMD parameters for the titratable groups of SNAC and non-standard amino acids following standard best practices as detailed in the Supplemental Methods section. All of our CpHMD parameters are provided in Supplementary Table and Supplementary Figs. 8-13. Furthermore, to mimic the localized SNAC-buffered environment around the tablet, which is less acidic than the rest of the stomach, 5