Hybrid hydrogels with their diverse chemical composition and variety of interactions offer a versatile platform with great potential in biomedical applications. In this section we have highlighted some examples in key areas, emphasizing how the contribution of each component led to improved performances. To offer an overall view of the work carried out to date, Tables and provide a comprehensive compilation of successful studies with in vivo validation in animal models. In addition, Tables and present promising hybrid hydrogels which, although evaluated so far only using in vitro biological models, have shown clear evidence of biological relevance.