One of the earliest papers on the use of paper-supported electrochemical devices for heavy metal detection was published by the Whitesides group in 2010. They demonstrated the sensing of heavy metals through anodic stripping voltammetry, which has since been further investigated by other researchers. However, the interactions between heavy metals and cellulose groups in the paper can introduce challenges to the measurement process, and this work aims to better understand and mitigate their negative impact. By improving our understanding of these interactions, new approaches can be developed to create more effective paper-based sensors for heavy metal detection.