In the same vein, combining these features offers an effective strategy for designing MOFs tailored for DAC application. For example, MOF named SIFSIX-18-Ni, which was demonstrated exceptional trace CO2 capture capabilities in humid conditions, incorporates three key features: azole linker, -CH3, and -EN. As shown in Supplementary Figure , SIFSIX-18-Ni consists of a tetramethyl bipyrazole organic linker (a methyl functionalized azole-based linker) and a SiF6 2-pillar (an electronegative functional group). The methyl groups on the organic linker act as water-blocking groups and the F atoms of the SiF6 2-pillar are working as nucleophile sites to interact with the electrophilic C atom of the CO2 molecule.