We can speculate on how this might affect the desalination performance of temperature swing solvent extraction, TSSE, one of the applications of switchable amine solvents. 5,8,32 DIPA in contact with a brine at low temperature will take up water from the brine. Our results suggest that initially, this is done through direct hydrogen bonds between the water and the DIPA. Such close coordination between individual water and DIPA molecules is likely to exclude charged salt ions, meaning that water can be extracted from the brine. It is interesting to speculate on what happens when a sufficient amount of water is absorbed into the DIPA-rich phase, allowing inverse micelles to form. On the throughput side, this helps the TSSE process, since more water can be moved out of the brine in each cycle. However, since the water structure at the center of the inverse micelles resembles nano-phase-separated water, we might speculate that salt could also be accommodated into the micelles, a phenomenon that could give rise to the salt selectivitywater productivity tradeoff seen in TSSE. A better understanding of the structure of amine-water-salt mixtures can help us to develop and select solvents that optimize the balance between throughput and selectivity. Similar arguments apply to the case where solvents are being used for ion extraction from water.