In this work, we introduce cg_openmm, a Python-based framework for setup, execution, and thermodynamic analysis of coarse-grained foldamer replica exchange molecular dynamics (REMD) simulations, and analyze_foldamers, a companion Python package for structural analysis of coarse-grained foldamers. These software packages serve as the foundation of a broader effort to understand heteropolymer secondary and tertiary structure formation as a function of molecular parameters.