Recent developments in analyzing SP(A)R include constellation plots. Briefly, constellation plots are 2D graphs that combine the clustering of compound datasets based on chemical scaffolds (in particular, analog series) and the distributions or mutual relationships of analog series based on fingerprint representations. Recently constellation plots were used to analyze the SAR of a large dataset of small molecules tested in a panel of cell lines using high-throughput screening. The authors identified a consistent cell-selective analog series of chemical compounds and proposed statistics to quantify cell promiscuity and consistency .