As an extensively used herbicide, atrazine (ATR) has drawn our attention as a model contaminant. The wide usage of ATR over the years for controlling broadleaf weeds in commercial crops has resulted in its accumulation in soils, groundwater, and crops. Given its role as an endocrine disruptor and its carcinogenic potential, the presence of ATR leads to enduring environmental concerns. Many approaches for ATR elimination have been deployed, such as physicochemical (e.g. adsorption), chemical (e.g. Fenton/Fenton-like reactions, electrochemical, and photocatalysis), and biological solutions. Under the umbrella of biological methods, laccases can catalyze reactions that are responsible for ATR degradation. For example, plant laccases as oxidases have shown to be capable of oxidizing the ethyl side of ATR. Fungal laccases generally have high redox potential which makes them more favorable than plant or bacterial laccases. Nevertheless, little is known about detailed studies of fungal laccase-mediated ATR degradation systems and underlying mechanisms. Therefore, ATR serves as an ideal model contaminant for understanding the environmental implication of BNNSs immobilized laccases.