Reasonable geometries can already be obtained with a simple AC(1)-QM/MM treatment at essentially the same cost as a gas phase calculation. The level of accuracy is higher for systems without intermolecular hydrogen bonding. Cohesive energies can be obtained as well, but are significantly overbinding due to the simple description of electrostatics. The inclusion of two-body corrections (and implicit inclusion of higher order electrostatic interactions), leading to the AC(2)-QM/MM scheme, shows a significant improvement compared to the one-body level. While cohesive energies are still systematically overestimated with respect to experimental results, a systematic trend is observed. In comparison with plane-wave results, an overbinding in the range of 16.5 to 5.6 kJ•mol -1 for all 23 benchmark systems can be found, which seems to be a quite consistent behaviour of our model. Our results seem to indicate that most of the error is due to BSSE, which accumulates through the two-body corrections.