In CPI, the hazard-formative factors refer to the uncontrolled energy in the industrial process or the natural phenomena, which may be accidentally released . The uncontrolled energy takes different forms for different hazards, such as the ground motion caused by earthquakes, the hydrodynamic shock caused by floods, the thermal radiation caused by fires, and the blast wave caused by explosions . The hazardformative environment refers to various factors that cause the damage or failure of energy or dangerous substance restraint or restriction measures, such as human errors, equipment failures, and natural events . The hazard-affected objects determine the severity of the final accident loss, which are the bearing objects of hazards . The bearing objects of hazards usually include various system units of the MSMPS-CPI, humans, properties, and environments . The regional disaster system theory emphasized the irreplaceable overall functionality of the interactive mechanism between the elements in the system. After the occurrence of the primary hazard, the hazard-affected objects and the hazardformative environment are exposed to the hazard-formative factor, leading to a series of secondary hazards. With the expansion of the accident scenarios, two or more hazards may be combined in an isolated, simultaneous, or chain reaction manner, resulting in the formation of the multi-hazard coupling scenarios According to the extracted knowledge, five general forms of multi-hazard coupling effects are defined from the aspects of hazard-formative environment and hazardaffected objects, including Sequential, Synchronous, Primary Scenario, Impeding Recovery, and Change Condition. The details of the five coupling forms are stated as follows: