Synthetic biodegradable polyesters such as polycaprolactone (PCL) based fibers show potential for medical applications in tissue regeneration, drug delivery, and artificial vascular grafts . Although the physical and chemical properties of PCL are well-studied, there is limited research on biomolecular and cell interactions with its surface. Understanding these interactions is crucial for evaluating the interaction of biological systems with PCL-containing materials. Protein adsorption is an important parameter for medical materials that come into contact with bodily fluids, such as blood, plasma, or serum, and significantly affects cellular response and biodegradation .Protein adsorption at the biomaterial-blood interface can influence the host response to materials, including coagulation, complement activation, and platelet activation . It is becoming apparent that blood composition is dynamic and highly dependent on the type of disease and its pathogenesis . In the case of kidney failure, it is well known that a reduction in glomerular filtration rate leads to the retention of metabolites (i.e., uremic toxins) in the blood . This work is a first step in understanding the effect that blood-borne uremic toxins (UTXs) has on plasma protein adsorption and subsequent hemocompatibility of these materials.