The development of therapeutic medications often relies on late-stage modification of complex or bioactive molecules. To demonstrate the versatility of our method, we subjected a series of natural product-and drug-conjugated substrates to standard reaction conditions. Notably, D-Glucose, D-Valine, Probenecid, Ibuprofen, Oxaprozin, and Pentoxifylline-derived allyl carboxylates reacted well, providing the desired products (2am-2ar) with yields ranging from 43% to 83%. Furthermore, derivatives of Cholic acid and Estrone showed good reactivity, producing products (2as-2at) with yields of 66% and 70%, respectively.