• Targeting the pathogen genes required for replication or entering or infecting the host cells or • Altering the host genes required by the pathogen to cause infection or • Modifying the genes responsible for drug resistance or susceptibility CRISPR-based antimicrobials have a unique advantage over other conventional antimicrobials because they can destroy microbes based on their genomic sequence. This is particularly useful in situations where only a small number of microbes within a genus must be targeted and eradicated, which is tough to do with existing antimicrobial strategies. Table enlists numerous studies conducted for exploring CRISPR based therapeutics as antimicrobial agents.