Controlling the extent of molecular similarity between generated molecules and given parent molecules may be necessary in some instances. Therefore, we explored prompts Q, R, and S(Figure ) to achieve varying levels of Tanimoto similarity. The LLM is able to effectively distinguish these levels, from the descriptive prompt keywords "barely similar (very low Tanimoto similarity)" giving the lowest median Tanimoto similarity of 0.09, "moderately similar (moderate Tanimoto similarity)" yielding the highest median of 0.63, and "marginally similar (low Tanimoto similarity)" producing an intermediate median of 0.37. The median Tanimoto similarities for the base prompts A -D ranged from 0.67 -0.69. Hence, with the controlling prompts Q, R, and S, the LLM is able to quantify different levels of similarity to the given parent molecules based on the keywords used in the prompt.