Considering the nonplanar structure of metallacarboranes, which enables the 3D arrangement of substituents, as well as their high interaction capacity and their affinity to large, flexible, and open enzyme active sites, metallacarborane-based compounds may be well suited to target nucleic acidbinding proteins. Furthermore, in contrast to other bulky scaffolds, such as C60 fullerenes or carbon nanotubes, metallacarboranes are indifferent to DNA, enabling selective protein binding. No such metallacarborane-based compounds are known yet, so further studies must be conducted to test this hypothesis.