In general, the reactions performed in 2-MeTHF also form the aforementioned side products, but gratifyingly when the reactions were run in the 15 -20 V range in 2-MeTHF, only trace amounts of side reactions from quinoline 1 were observed (see Supporting Information Table ). Thus, 2-MeTHF as the reaction solvent in this system offers several clear advantages, namely: 1) the ability to run the process at -40 °C rather than -78 °C, 2) improved stereoselectivity with the temperature increase, 3) lower reaction volumes, 4) considerably less impurity formation, and 5) 2-MeTHF can be easily dried via azeotropic distillation, a clear advantage over THF. All of which greatly improve the prospects of manufacturing BDQ