We tracked the protocol work across move attempts for MolDarting the various HIV integrase ligands. The first column specifies the PDB code corresponding to the ligand under study. The second column tracks the average protocol work (in units of k B T ) and the standard deviation for 1,000 NCMC steps. The third and fourth columns follow the same format as the second but give the average protocol work for 10,000 and 50,000 NCMC steps respectively. Here we see that the protocol work roughly scales with ligand size, with the smallest ligand, 4CJV, having the lowest protocol work values. We looked at two possible sources that could lead to these MolDarting moves being rejected. One possible source of rejection is that the ligand falls outside the regions when MolDarting is being attempted, leading to these moves being rejected.