To assess the accuracy of the MFCC and MFCC-MBE(2) schemes for the calculation of protein-ligand interaction energies, we consider a test set of seven protein-ligand complexes. This test set was assembled by considering examples of protein-ligand complexes previously studied with fragmentation methods (1STP ) or other computational approaches (2PK4 , 2IFB , and 1TOW ). These were complemented with additional test cases (1AAL, 1ABA, 1A6F and 4A4E) that we chose from a search of the protein data bank for protein-ligand complexes featuring protein and ligand sizes that still allow for full quantum-chemical reference calculations. Our test set consists of a 30-51 disulfide mutant of basic pancreatic trypsin inhibitor in complex with a phosphate ion (PDB-code: 1AAL ), the human plasminogen kringle 4 in complex with ε-aminocaproic acid (PDB-code: 2PK4 ), oxidized bacteriophage T4 glutaredoxin (thioredoxin) in complex with a MES-buffer molecule (PDB-code: 1ABA