Mass spectrometry is an analytic tool that is used to measure the mass-to-charge ratio of the present molecules. They detect the type, amount, structure, and chemical composition of the compound (Broad Institute, 2021). Although mass spectrometry is less sensitive in diagnosing COVID-19 compared to PCR and some of the other methods, it can identify the metabolomic, lipidomic, and proteomic profiles that are related to the diseases' profiles . However, the original purpose of this technology was not to replace DNA or RNA sequencing, but rather to provide an alternative to diagnosing the virus and its mutants with the proteins they produce .