In the literature, different dissolution behaviors were described when adding a plasticizer to a polymer-drug blend. For some polymer-drug-plasticizer blends, the addition of the plasticizer resulted in faster drug release, probably due to weakening of the polymer-polymer interaction. For other systems, no influence was observed, or even the inverse behavior, where the addition of a plasticizer resulted in longer dissolution time. This makes it difficult to predict the influence of the plasticizer on the polymer blend and its dissolution. Here, polymers of the same polymer class but with different hydrophobicity of the polymer middle block were used, revealing different influence of the plasticizer on the printed scaffolds in the dissolution tests, which makes it necessary to investigate the influence of the plasticizer for every blend separately.