After preparing the VHL ligands (VH032, MeVH032, and cisVH032) and required linkers (Scheme S1), the homo-FerroTACs were assembled around the 1,1'-dicarboxylic ferrocene core in a convergent manner, as depicted in Scheme 1. The 1,1'-ferrocenedicarboxylic acid was converted to its corresponding acyl chloride and combined with the appropriate amines 7a-c to give AS1, cisAS1, and AS2, respectively. A different synthetic approach was used for the hetero-FerroTACs AS3 and AS4, as shown in Scheme 1. Asymmetric mono-functionalisation was achieved through HATU-mediated amide coupling with an excess of 1,1'-ferrocenedicarboxylic acid. The resulting intermediate 1 underwent further amide coupling with the corresponding amino-pomalidomide derivatives 8 and 9, yielding compounds AS3 and AS4 in moderate yields. To facilitate the asymmetric functionalization and synthesis of hetero-FerroTACs (Scheme 2), we introduced an alkyne handle on the ferrocene core following an established literature procedure. The ferrocene building block was synthesised starting from the methyl ferrocene carboxylate to produce the 1,1'-carboxy-ethynylferrocene 2 in 74% overall yield, through riedel-rafts acylation followed by a Vilsmeier-type formylation and a final elimination step. After activation with HATU and subsequent addition of pomalidomide-( ) and JQ1-aminoderivatives (10 and 11, Scheme S1), the intermediates 3, 4, and 5 were obtained, respectively. Using a copper(I)-catalysed a ide-alkyne cycloaddition uAA protocol, 1,2,3-triazole moieties were formed as linker connections by reacting VHL-PEG3-azido 6c with the previously described ferrocenylethynes yielding compounds AS5, AS6, and AS7, respectively.