The hydration free energy and differences in hydration free energy between fluorinated and nonfluorinated amino acids are presented in SI Table ; also presented are the Coulombic and LJ components of the hydration free energy. Values for ethylglycine (ETG), valine (VAL), isoleucine (ILE), leucine (LEU) and all fully fluorinated amino acids (E3G, V3S, V3R, V6G, I3D, I3G, L3S, L3R, L6D)