Since the groundbreaking discovery of penicillin in the last century, small molecule antibiotics have been widely used for preventing or treating bacterial infections in humans and animals . As a consequence, large quantities of antibiotic substances have been released into wastewater, contaminating groundwater, rivers, and the sea . Exposure to antibiotics in water bodies Synthetic peptides displaying the amphiphilic amino acid pattern Pro-X-(Phe-X)5-Pro, in which the backbone consists of hydrophilic amino acids (X) alternating with hydrophobic phenylalanine residues and prolines at the termini, were shown to adopt β-sheet fibril organization . Specifically, a cationic Pro-Lys-(Phe-Lys)5-Pro variant (denoted PFK), designed for the templating of metallic gold nanofibers and as a drug delivery vehicle , was shown to adopt β-sheet-based fibrillar structures . Importantly, the alternating lysine/phenylalanine sequence of PFK may mimic PSMα3 catalytic activities.