The highest affinities were employed as the main selecting criteria for the top-children derivatives, because they may allow for lower concentrations and reduced side-effects if tested for possible biological activities. The number of raw-children corresponded to the DWBEL total randomly generated new molecules after 3 consecutive runs per parent. The number of Non-toxic Fitted-children corresponded to the children best-fitting the Vif red sA3G cavities. ADV corresponded to the number of Non-toxic Fitted-children predicting ADV blind-docking (45x45x45 Å grids) < 46 nM. %, calculated by the formula, 100 * number of ADV / number of Non-toxic Fitted-children. Bold %, percentage of Vif8-and star30-derivatives with the highest affinities.