MOFs have been extensively explored for their vast potential. and remain at the cutting edge of research, with their deployment in the life sciences applications still on the horizon. The ability to immobilize GUVs using micron-sized MOF and GUV adducts without significantly compromising the structural integrity of the membrane is a standout aspect of this study, paving the way for prospective biomedical applications. We have adopted a straightforward and reproducible method to efficiently immobilize GUVs with aluminium, zinc, copper, iron, zirconium and calcium containing MOFs using saturated, unsaturated, and negatively charged lipid mixtures. The results revealed that CuBDC, HKUST-1, UiO-66, MOF-808, MIL-100(Al), and MIL-100(Fe) supported GUV formation and immobilization, which can be utilized in advanced bioimaging and tailored for advanced drug delivery applications. GUVs remained anchored to the zirconium and copper MOF surfaces for a remarkable period of 12 hours. The GUV yield in MIL-53 MOFs was comparatively higher than MIL-100 frameworks but the former showed fewer GUV immobilization.