Constellation plots have already been used to aid the visualization of chemical space for different practical applications. For example, the authors analyzed the results of a docking-based virtual screening of 2789 molecules from a commercial virtual library focused on inhibitors of DNA methyltransferase (DNMT). The docking scores were visually represented on the plot, enabling the rapid identification and grouping of analogs (e.g, "constellations") of compounds to be prioritized for further screening. Constellation plots have also been used to explore the SAR of 827 inhibitors of AKT1 obtained from a public database, and the structuremultiple-activity relationships -SmART-of 286 molecules experimentally tested as inhibitors of three DNMTs and assembled from public sources consistent cell-selective analog series of chemical compounds. This analysis was done through a systematic analysis of high-throughput screening data of 41,821 compounds consistently assayed against the same panel of 73 human cancer cell lines used by the National Cancer Institute of the United States. In that study, the most relevant analog series were identified as measured by a therein developed combined selectivity and consensus score. Also, all the 3,750 cores of the entire data set were used as queries or reference structures to virtually screen the entire ZINC 15 database identifying 82,409 purchasable analogs for 1,980 of the 3,750 cores. One more recent application of the constellation plots was to contribute to a comprehensive SAR analysis of 851 compounds tested as tubulin inhibitors and bioactivity data in different cancer cell lines. A total of 147 analog series were identified and analyzed in a constellation plot. Visual analysis of the plot (an interactive version of the plot was made freely available using DataWarrior, rapidly identified "bright" and "dark" regions in chemical space, i.e., analog series with overall high and low activity, respectively, as inhibitors of tubulin. The code to generate constellation plots is freely available at .