In an effort to synthesize sugar esters-based mangiferin derivatives, in the solution of ram mangiferin with dioxane, ethyl propionate, and in the presence of the immobilized lipase enzyme in a water bath at 60 °C for 24 hours, the reaction mixture was further concentrated with the help of a rotary evaporator that provided a residue that was subjected to purification with column chromatography using chloroform : methanol as eluent to provide the desired compound 1. Scheme 6. Synthetic route and its sugar ester derivative of mangiferin Synthesis of second sugar ester-based derivative of mangiferin, using raw mangiferin mixed with acetone and Propionic acid in the presence of immobilized lipase lipozyme in a water bath with thermostat control table at 60 °C for 24 hours, the reaction mixture was further concentrated with the help of a rotary evaporator that provided a residue that was subjected to purification with column chromatography using chloroform : methanol as eluent to provide the desired compound 2.