showed signs of toxicity at the highest tested concentration (1 mM). For the other compounds, no detrimental effects could be observed in the larvae over the monitoring period. These data contribute to our understanding that metal complexes need not be considered as generally toxic. Nevertheless, factors such as the metabolism, excretion and/or accumulation of the various metal complexes and their metabolites will still need to be studied more rigorously in models if they are to be advanced into the preclinical pipeline. Of note, the maximum concentration reached in the larvae in these assays is anticipated to be significantly lower than the concentrations measured in the in vitro toxicity/haemolysis assays. Pt2-treated larvae showed CFUs comparable to the DMSO control, indicating that no significant biological effect was achieved by this compound at the tested concentration (Figure ). On the other hand, a significant reduction in CFUs was detected for the control compound fluconazole (1.1 log10) and for compound Pt1 (0.7 log10). These data indicate that Pt1 is able to reduce the fungal burden in a living organism. Together with the data on its promising antibacterial properties, Pt1 and its related compounds seem to be a promising starting point for a novel class of antimicrobial agents.