In the last decades, surface enhanced Raman spectroscopy (SERS) has been widely recognized as a powerful and versatile analytical tool for multiple applications ranging from environmental science to biology and nanomedicine. The unique advantages of SERS, including its exceptional sensitivity, specificity and access to biochemical information, have positioned SERS-based techniques as powerful optical diagnostic tool, enabling a valuable alternative to conventional diagnostic methods like fluorescence-based spectroscopy. Nowadays, it is well known that the Raman signals of molecules adsorbed on nanostructured metallic surfaces are enhanced of several orders of magnitude (from 10 2 to 10 10 depending on the type of substrate) due to the local enhancement of the electromagnetic field resulting from the Localized Surface Plasmon Resonance effect. Among various metallic nanoparticles (NPs), gold nanoparticles (AuNPs) emerge as the most efficient substrates for ultrasensitive SERS detection. These NPs can be functionalized with Raman-active dye molecules (Raman Reporters, RRs), characterized by narrow Raman peaks, thereby forming "SERS tags", which serve as contrast agents in bioimaging applications, and function as sensing probes targeting minute analyte concentrations in diluted liquid samples . Furthermore, the aggregation of NPs into fractal architectures introduces additional enhancement, creating localized hotspots at NPs' junctions. Despite the great potential, the fabrication of SERS tags, particularly those containing NPs, is still extremely challenging. The main challenge in the fabrication of SERS tags composed of NPs relies on the retaining of i) colloidal stability, ii) biocompatibility, and iii) tag specificity after the surface functionalization with RRs. Consequently, Raman tags based on NPs' clusters necessitate a delicate balance of the RRs/stabilizer ratio to ensure a robust SERS signal without inducing uncontrolled aggregation. Although numerous strategies have been proposed for fabricating efficient SERS tags with high targeting efficiency and SERS intensity, as well as long-term colloidal stability, these methods often involve time-consuming and multiple-step syntheses, leading to NP aggregates lacking in reproducibility and structural stability, usually dependent on the RR chemical structure. In summary, a simple, reproducible, and versatile strategy for developing RRs-AuNPs clusters as SERS probes is still lacking.