To explore the practicability of this method and the applicability of the aziridines, the model aziridine 2 could be prepared on a 20 mmol scale in 95% yield. As shown in Scheme 4, aziridine 2 can undergo nucleophilic ringopening reactions with nucleophilic reagents like ptoluenethiol to yield cyclooctamine 40 in 71% yield (Scheme 4a). 20 Additionally, 2 can also undergo condensation with picolinic acid, followed by cyclization under the NaI/acetone conditions (Heine reaction) to form oxazole compound 41 in 73% total yield (Scheme 4b). 21 Furthermore, 2 can not only engage in Chan-Lam-Evans coupling with arylboronic acid compounds under copper catalysis but also react with vinyl bromides under palladium catalysis via Buchwald-Hartwig coupling (Scheme 4c, d) to produce 42 and 43 in 60% and 52% yield, respectively. 22,23