Ethyl acetate extracts were analyzed using UHPLC-HRMS/MS-CAD-PDA. Prior to analysis, too apolar compounds of the extracts were removed by C 18 solid phase extraction (SPE 1,000 mg/12 ml, Finisterre, Teknokroma, Barcelona, Spain). About 10 mg of extract was loaded on the cartridge, followed by elution with 10 ml of methanol (MeOH). The prepared extracts were dried under nitrogen flux. For UHPLC-PDA/HRMS 2 /CAD analysis, extracts were diluted in MeOH at a 5 mg/mL concentration. Chromatographic separation was performed on a Waters Acquity UPLC system interfaced with a Q-Exactive Focus mass spectrometer (Thermo Scientific, Bremen, Germany), using a heated electrospray ionization (HESI-II) source. Thermo