Hybrid molecular docking combines the strengths of both global and local docking approaches. It initially employs global docking to explore potential binding sites across the target surface. Then, it refines the search using local docking techniques to focus on the most promising regions, enhancing the accuracy and efficiency of the docking process ( ). For example, the hybrid global docking example is LigDockCSA ( ), which combines conformational space annealing (CSA) with AutoDock's energy function. It has an 84.7% success rate, compared to 80.5% for GOLD and 81.7% for AutoDock. Also, the success rate of LigDockCSA becomes 89.4% with the help of conformational entropy ( ). The examples indicate that hybrid molecular docking provides more accurate results.