In our study, the PDMS membrane is used to connect a reactor with two compartments [Fig. (C)], whose contents differ only in the absolute configuration of the chiral catalyst describing a mirror system. At the start of the reaction (t0), each compartment is physically identical and filled with the same quantity of racemic non-polar substrate (A/ent-A) and reactants, avoiding any osmosis phenomenon. Over time, each enantiomer of the substrate will be able to cross the membrane and eventually reach the compartment containing the enantiomer of the catalyst that ensures its fastest transformation in the polar enantioenriched product (B/ent-B), which will no longer be able to return to the other side due to its higher polarity. One key point is that each enantiomer of the catalyst should face the racemic mixture of the precursor and full conversion is desirable and expected, at the difference of a classical KR process.