In recent years, the development of synthe7c ion transporters has become an area of great interest, due to the key role of transmembrane transport in metabolic processes in living organisms. Various diseases are linked to deficient or poorly regulated anion transport and synthe7c ion transporters hold therapeu7c poten7al for such channelopathies. Addi7onally, synthe7c anion transporters have also been employed to disrupt homeostasis of cancer or bacterial cells. For both types of applica7ons, precise control over the ac7va7on of the anion transport is desirable. Examples of s7muli-responsive transport systems have been reported, star7ng with pH-controlled anion transporters, 9,10 and followed by numerous transporters that are controlled or ac7vated by light and redox reac7ons and that have been discussed in three recent reviews. Dynamic Covalent Chemistry (DCvC) is a well-established concept for the synthesis and in situ modifica7on of organic structures and supramolecular systems by covalent bonds which become reversible under specific condi7ons. Examples of such reversible bonds include imines, acylhydrazones, disulfides, boronic acids, ortho-esters, and tetrazines. DCvC has already been used in various applica7ons, such as drug delivery, gene transfec7on, thiol-mediated uptake, dynamic self-assembly of amphiphiles, or in other smart biomaterials. However, applica7ons of DCvC in well-defined molecular structures for ion transport applica7ons are rare. An imine-based system has been employed to transport Ca 2+ ca7ons through a chloroform phase in U-tube experiments. Ion channels have been formed by the DCvC of acylhydrazones to obtain helical structures or by linking two cyclodextrin units via disulfides inside the membrane. Bravin and Hunter have shown that the lipid membrane of ar7ficial liposomes can be used as a template, amplifying the concentra7on of lipophilic product in a dynamic combinatorial library based on thiols and Michael receptors. In a follow-up study, the same DCvC was used to transport thiols into liposomes for the ac7va7on of a caged enzyme encapsulated inside vesicles, demonstra7ng transmembrane signal transduc7on. Finally, imine forma7on was used to enhance the transport of amino acids by synthe7c anions transporters.