-StarShapedLigands.dwar Contains small star-shaped tripartite molecules manually designed by 2D drawing different central atoms / rings and sizes and 3-6 carbon arms ended by alanines. The designed 2D molecules were manually drawn in MolSoft. To conserve their 2D geometries during ADV docking, optimal conformers were generated by the DW / mmff94s+ force-field algorithm The best ADV conformer docking to gpGVHSV R4-TrD interface contacting all the A,B,C chains of the trimer, was conformer number 30 (cn30). The cn30 conformer was input parent and cavity for DWBEL co-evolution. Files *.dwar can be opened in DW, freely available at -549Children-gpGvhsv.dwar. This *.dwar DW tables contain 549 top-3D conformers selected by their ADV affinities by 4-runs. The table is provided with threshold slider-filters to their DW_BEL and ADV docking-scores, Molecular weights and logP properties, to select for particular threshold combinations. Files *.dwar can be opened in DW, freely available at -nearby11.py. To compare the cavities preferentially targeted by thousands of new children-conformers, the percentages of docked cavities in gpGVHSV were approximated with the PyMol-Python script nearby11.py. The different gpGVHSV cavities were defined by their three most characteristic amino acids as: Bc (around the bottom-cavity at the end of the TrD helix) = 317D and/or 320S and/or 335K, R4-TrD (around the R4-TrD α-helix interface) = 67E and/or 304H and/or 307T and Sc (around the trimer side-cavities) = 296T and/or 366S and/or 411Y. The script calculated the percentages by the formula, 100 * number of children in each virtual cavity / total numbers of children docked. Copy all files into the same directory ( *.py, gpGVHSV and output_number.pdbqt). Open the gpGVHSV file in PyMol and load the Python script by PyMol/File/Run Script/*.py.