All chemicals were purchased from Sigma-Aldrich. Solvents used for the reaction or purification of the product were purchased from Across Organics, VWR, Penta and Eurisotop in the case of deuterated solvents. Deuteration experiments were performed on a customised stainless deuterium manifold system (RC Tritec AG, Teufen, Switzerland) using deuterium gas (99.8 atom% D, Sigma-Aldrich). Flash chromatography was carried out on a CombiFlash ® NextGen 300+ instrument (Teledyne ISCO, Lincoln, Nebraska). 1 H and 13 C NMR spectra were recorded on a Bruker Avance II spectrometer at 300 MHz and 75 MHz, respectively, at 25 °C. NMR spectra were calibrated to the signal using the residual nondeuterated solvent (2.50 and 39.52 ppm for DMSO-d6). LC-MS analyses were performed on the Waters Alliance HPLC system with a Water SQ Detector 2 quadrupole mass detector using ESI ionization mode.