Both compounds are poorly water soluble; the solubility of PTX is about 0.4 -4 μg/mL, 68 while the solubility of CUR is in the range of 1 -10 μg/mL, 69 depending on the polymorph. This poor solubility is one of the major problems for both compounds. Accordingly, both compounds have seen extensive efforts to improve their apparent solubility and thus, bioavailability. Among the plethora of drug delivery systems investigated for formulation of PTX and CUR, some POx and POzi based formulations stand out for their extraordinary high drug loading capacity and overall solubilisation for PTX and CUR. While CUR is achiral, PTX is chiral with multiple chiral centers but, to the best of our knowledge, does not have a known enantiomer. The formulations were prepared by the thin film hydration method. Briefly, ethanolic solutions of the polymer and drug were mixed in desired ratios, followed by ethanol removal.