Drug sensitivity in cell culture SKOV3-ip1 and SKOV3-TRip2 cells were plated at a density of 3 × 10 3 and 6 × 10 3 respectively in 96 well plates. The next day, cells were treated with increasing concentrations of paclitaxel (Adipogen, Life Sciences, UK) for 72hrs. Complete media with no drug was used as a control. For cell viability measurements, cell culture media was removed and replaced with 100 μL of 0.5 mg/mL MTT dissolved in complete cell culture media. Plates were protected from the light and incubated for a further 4hrs at 37 o C. The MTT solution was removed and replaced with 100 μL dimethyl sulfoxide (DMSO). Absorbance was measured at λ = 570 nm using a Multiskan FC Absorbance Plate Reader (THERMO-LABSYSTEMS). Viable cells were calculated as a percentage of the control group treated with no drug. Dose-response curves were generated and from them half-maximal growth inhibition (EC50) values were determined using GraphPad Prism (sigmoidal dose-response, fixed slope; v.8.0).