Unlike MC, the simulation of the transition state analog (TSA) with WT shows a stable complex during entire simulations. A consistent interaction is shown with R7 and Tyr108 which also shows more favorable interactions relative to MC. Therefore, in nutshell, the chorismate mutase has evolved in such a manner that the local electric field produced by enzyme reduces the entropic penalties of the transition state analog (TSA) and thus lowers the overall barrier of reactions.