DW cluster analysis of the children structures of library C identified, at least, 4 main scaffolds which contained representative molecules of 3, 4 or 5 molecular rings (Figure ). A graphic representation of the 150 children docked to rat VKORC1, predicted coverage of the top of the VKORC1 cavity. Most of the 150 children were slightly rotated to the opposite part of the brodifacoum hydroxycoumarin head and included similar but smaller hydrophobic tail cavities than brodifacoum (Figure ). The amino acid interactions of the corresponding 4 representative molecular scaffolds, showed maximal numbers of Hydrogen and hydrophobic bonds to amino acids of the rat VKORC1 cavity and numerous newly predicted amino acid contacts (Table , green rectangles).