The simulations were performed considering different cutoff radii R c . For the FG reference systems (s max = 1, both slab and spherical geometries), R c was set to 1.2 or 1.4 nm (in some cases also 2.4 nm). In the scaled setup (s max = 1.5 and 2.0), the values considered are R c = 1.8 nm for s max = 1.5, and R c = 2.0, 2.4 or 2.8 nm for s max = 2.0. The use of larger cutoff distances in the AdSoS setup (relative to the value of 1.4 nm typically employed in FG simulations with GROMOS) is rendered necessary by the linear scaling of distances (Table ), which leads to an effective interaction range reduced to R c /s max in the CG region. Note that even if raising R c in proportion to s max offsets the computational gain of AdSoS on a per molecule basis, the approach remains very advantageous because the number of solvent molecules is considerably reduced compared to a FG system filling the same volume.