constipation, chronic
"I rated Linzess a 9 because it works, but it is STILL a drug, with unknown long term effects.  I have decided to take that risk for quality-of-life reasons.  I have been on it for 18  months (145mg once a day), and it works very well for me.  I got headaches at first, but that subsided.  I gained 5 pounds, but that may be due to other factors.  I used to take Aloe 450 capsules twice a day - DON'T DO IT.  That resulted in the worse case of melanosis coli my Gastro has ever seen; time will tell if it is reversable.  I had severe constipation and crippling gas pain for 30  years before diagnosis of IBS.  With Linzess, I have normal BMs 80% of the time (diarrhea 10% and constipation the other 10%).  Gas pains are rare (usually when stressed)."