depression
"I'm on the second week and I do not feel as sad and anxious. Upset stomach for a couple of days but is wasn't too bad. I was diagnosed with being homozygous for the 1298C MTHFR mutation. Anyone dealing with depression should be tested. The problem with having this mutation is you have a problem with methylation so you can't make enough dopamine and seratonin.  Also you have a problem with norepinephrine and which causes anxiety.  Defects on the 677 /MTHFR gene can cause bipolar and schizophrenia.   To help with methylation need to take Methyl B12 and folate (not folic acid)... people with these defects can't process folic acid. That is why Dr.'s add Deplin to prescribed medicines.  "