depression
"I have been on bupropion for about a year, 150mg taken every morning.  I noticed a difference on day 2.  Everything was just normal.  Not bad normal, but good normal, like you woke up after having a really good sleep - and like a weight or pressure has been lifted.  It's really hard to describe.  Everything seems better. I kid you not.  Music sounds clearer, looking around outside, it looks clearer...like I am out of a fog.  So...I tried an experiment while I went on vacation.  Didn't take anything for 2 weeks.  My mood slowly returned to negative.  Little things ticked me off, that shouldn't have.  I decided to go back on.  Same effect on the next day, mood lifted.  It gives me slight insomnia, but also takes away some appetite. Great."