depression
"I have been on Tramadol (50mg 3x per day) for about 6 years now.  For the first few years is was a miracle cure.  I have struggled with depression/anxiety/impulse and obsessive disorders my entire life.  This made me finally feel free and human for the first time ever.  The only downfall was after a few years, the effects wore off, and slowly my depression/anxiety began to creep back in.  I took a break from it for a few months (warning: withdrawing from Tramadol is reallllly uncomfortable).  I went back on it after my Dr assured me it was a good med (even long term) for fibromyalgia/depression, etc.  I'm up to about 4/day now.  It still helps, but not nearly as much in the beginning."