ibromyalgia
"I have had been diagnosed with fibromyalgia for 14  years.  I am sensitive to all the medications usually recommended to treat it:  Lyrica, Cymbalta, Savella, amitryptiline and gabapentin.  They all give me agonizing headaches and make my brain feel like it's going to blow up.  So my doctor started me on Tramadol 6 years ago....and what an amazing thing, the pain was much better.  After all that time, I am now on the maximum dose per day and I know I am physically dependent.  But it is still the only medication that I can take long term that takes the edge off my fibro pain enough for me to function and work full time.  I have also developed osteoarthritis and it helps with that, too.  The only NSAID I can tolerate is naproxen."