depression
"I have suffered depression since childhood, also obsessive compulsive disorder and starting in my 20's major depressive disorder w/ psychotic features and massive anxiety.  I have been on many of the SSRI's and they even tried me on lithium on one occasion, but it seemed to do nothing.  One anti depressant that did work for me for 2 years was Nefazadone,  it made me feel normal and even above the normal line.  I am also diagnosed with dysthymia.  One day the nefazadone quit working and I went into a major depression for months.  I currently am on a high dose of Venlafaxine, 300 mg a day, but it is working.  About a half hour after taking my morning meds I start to feel a lot better, and anxiety is nearly gone."