actinic keratosis
"I have used Efudex for years on my severely sun-worshiped skin.  I could never tolerate more than 7-10 days, and never got great success. I tried Tolak once, with much better success.  The mode of delivery, inactive ingredients or something made a big difference, and I tolerated it almost 4 weeks. 1X a day app and something about it makes side effects milder, yet results better.  I ended up getting much better results than I ever got with Efudex.  I see some people here are discouraged that they don't get inflamed as soon as they do with Efudex, but the milder reaction allowed me to stay with it much longer.  I did get a severe reaction after the 3rd week, but excellent results.  Will use again....no more Efudex for me."