tourette's syndrome
"Prescribed clonidine in December when my motor tics had become debilitating. One pill three times a day didn't accomplish much. My neurologist upped my dose to 5 pills 3 times a day and my tics ceased completely within 10 days. When my life gets really stressful the tics come back, but a few days at 2 pills 3 times daily and they usually subside. Side effects with 3x5 daily were significant...could not stay awake for more than an hour or two at a time (couldn't drive) and the dry mouth (cotton mouth) was terrible,  but the tics went away.   Side effects with 3x2 daily are similar, but not as severe."