ankylosing spondylitis
"I have lived with Ankylosing Spondylitis since I was 14 (49 now).  Did okay with NSAIDS until about 10 years ago when it began to really get bad.  Started Humira 2 years ago.  It took about 4 months to really help my back.  Unfortunately lately it seems to be losing it's effectiveness.  Hopefully this is just a blip in treatment."