oophorectomy
"Had ophorectomy 8 years ago. On second week started to have terrible hot flashes, couldn't sleep any more.  Doctor started me on all you can name before trying Premarin. Since Premarin got my life back. Several times again Doctor tried to decrease the dose and ween it, in order to complete stop. I went into deep depression crying all the time and back to nightmare again. So thanks to Premarin I'm a normal human being again. As a floor nurse on a cardiac floor have talked to several ladies in their seventies that still taking Premarin daily.  My actual dose for years has being 0.65 mg daily."