bipolar disorde
"This pretty much saved my life. I've been on EVERYTHING (or so it seems) for major depressive disorder and when I was about 32 something wasn't adding up and I was diagnosed BP2. I tried Lamictal and I couldn't handle the headaches. The other BP medications all seem to cause weight gain so I'd stop taking them. I got a new doctor who said if I tried lithium she would give me a little Topiramate to help offset the hunger the lithium caused. Well, the topiramate seemed to help the BP2. So I've slowly worked up to 150/day topiramate along with wellbutrin and Lexapro. It's a GODSEND. 

Side effects: when titrating up at any point, tingly fingers or feet for a week but then goes away. Take at night because can make you sleepy. Hope FDA approves!"