pain
"My experience with Actiq was like a miracle.  I get many, very severe migraines, especially when I am in a stressful, rushed situation.  Some of these occasions are holidays, birthdays, etc.  I would try to prepare ahead of time, but frequently I would get a migraine.  When a bad migraine doesn't abate after the usual rescue and pain management medicines, I would take Actiq, without it I can't participate with my family to help with any preparations, spend any time with them, and can't even sit down to have a meal with them.  After several times of a ruined holiday or special times with family, they either forget you or resent you.  Children don't understand at all.  So, the next time there's a special event, you get nervous thinking of it."