acne
"I'm 42 and began taking spironolactone and using Differin for adult acne about a year ago. It took almost 8 months to really make a huge difference, but I could see some changes in the inflammation and severity of my acne after about four months. My acne was worse along the jawline and under my jaw, and usually manifested as deep, sore nodules that never really came to a head. I still get some breakouts but the pimples are much smaller and more on the surface, and almost none of them are on my jawline. They also heal much more quickly. 

The only negative side effects I've had are increased urination and weight gain. I've put on almost fifteen pounds over the last year, mostly in the belly, hips, and thighs."