generalized anxiety disorde
"I have been dealing with depression since 1990 and run the whole inventory of SSRI's available.  Prozac was effective the first 2 years then became ineffective. The only drug that has helped me for an extended period of time was Paxil.  Paxil eventually became ineffective after 5 years. So the wonder drug Cymbalta comes on the scene and I thought I had finally found the magical cure. I've been on 60 mg of Cymbalta for about a year and once again the roof is caving in and very abruptly. This past week I've been suicidal for 3 days.  Why? The circumstances in my life that so often can trigger anxiety or depression are the same as always.  How can an SSRI become instantaneously ineffective?  I'm not raving about Cymbalta any longer."