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"I have been on Depo on and off for a few years. I did experience some spotting but no heavy period. I have gained a good 15 lbs in the process. Coming off of Depo I gained an additional 10 lbs in 2 months or so. I had my last shot in October, it is now May and only had one short period that lasted for 3 days in March. When on Depo I have also experienced hair loss and difficulty sleeping, as well as a drop in my sex drive. "