chronic pain
"Very similar to MS Contin before manufacturer added a second drug-release regulating feature to the matrix. I found that every 12 hours allowed too low a trough in between doses, so my dose was divided into thirds for a  every 8 hour schedule.  I continued to work throughout the titration and stayed productive for a decade. Now I'm toast.  Any steady-state pain strategy will eventually change your body chemistry for ever, so it important to exhaust  all short-acting, prn "as needed" strategies first.  Be honest with your Doctor, it goes a long way."