depression
"Do not take if you are on Methotrexate and leflunomide for rheumatoid arthritis. It over rides the arthritis medication and makes you become inflamed again and you will have to go back on steroids. I only took this medication for three days and it made me sleep for 15 hours on the first night, the second night it over rode my arthritis medication and made my arthritis flare up and I couldn't sleep and the third night I didn't sleep and had a major migraine."