depression
"I had taken many SSRI antidepressants and none helped my depression. I finally insisted that I try something different. Desipramine works on norepinephrine and that made a big difference. My apathy was gone, no severe anxiety like I'd had from Prozac and Paxil. I knew it was working when I started cleaning my house even though my mood had not improved yet. SSRIs may be newer but not better."