migraine prevention
"I have chronic daily migraines, and have tried several medications for migraine prevention, including Depakote, Elavil (amitriptyline), nortriptyline, and propranolol.  The Depakote, amitriptyline and nortriptyline were too sedating.  The propranolol worked well, but I had too increase the dosage over time to the point where my blood pressure became too low.  Right now a combination of Topamax at 50 mg and propranolol extended release at 60 mg works best for me.  There are few adverse effects.  The Topamax does cause some frustrating cognitive difficulties but I think I can live with them, considering the relief it gives me from the migraines."