gout
"Started taking allopurinol at age 54 after trying to manage Gout through lifestyle and diet for 14 years. Adopted vegetarian diet, limited use of alcohol and was not overweight. What finally "cracked" me  was a severe attack in one of my ankles, whereas previous attacks (about 1 / year) always struck the left toe joint. Attacks were typically prompted by severe exertion and dehydration. Uric acid level had crept up to 7.2 and stayed there. Started on a regiment of 300mg Allopurinol  and 10mg/colchicine.  It prompted an initial, minor flare-up, but none since. Stopped the colchicine after 6 months and am continuing the allopurinol 300mg once daily. Most recent uric acid level is 5.2 and have had no issues, or side-effects."