inflammatory conditions
"I have Major Depressive Disorder and have been through a lot to get the right combination of anti-depressants to actual help me. I was put on Prednisone for systemic inflammation. The second day my mood just dropped. It felt like I had no anti-depressants in my system at all. It was awful. My PCP and therapist helped me through the worst part, but I don't think I will ever take Prednisone again. My taper was finished yesterday and today the pain is back. I rather deal with the physical pain than the depression. Nasty side effect. On the bright side; it did help with the inflammation and pain, even though it was temporary."