pain
"I've only been using Nucynta for a couple of days, but so far it is working very well for me with very minimal side effects.  I have chronic sciatica and have been on and off of low does Hydrocodone for a couple of years now.  I've been taking 50mg of Nucynta 2-3 times a day.  This seems to work almost as well on the pain and just seems easier on my body.  It does make me a bit "loopy" and a little groggy, but no more than the hydrocodone.  I also have noticed that I'm not as hungry, which is not necessarily a bad thing!  I will be interested to see how it works over time and whether it continues to work well over a period of time."