pain
"I've found that Nucynta (Palexia in Europe) has been a great for me.  I've had lumbar pain on and off for 35 years.  For the last seven years it's been chronic, sometimes incapacitating.  I was on the hydrocodone ladder (5, 7.5, 10), (x4, x6, x8,  per day) until a doctor where I work said "Whoa!  That's way too much Acetaminophen.  It's dangerous."  He prescribed Tramadol.  It helped somewhat - and had an upper limit (for me) of about 300mg/day before nausea set in.  A year and a half ago he suggested I try Palexia (the trade name in Europe).  What a difference it made!  Some tolerance (not much) and no dependence I can discern, nothing like the "codones".  Easy to lay off it whenever.  For me it's great!"