hypoestrogenism
"The gyno put me on 8 mg estradiol for 3 days, then 4 mg which quickly brought my non existent estradiol levels back to normal and stopped the horrible joint pains and anxiety. I had to lower the dose to 2 mg and even that is making me very, very tired. It also caused muscle atrophy! I used to be very lean and athletic now my body is soft and fatty. But....I sleep better and feel very relaxed. I'm 40 years old - and my hypothalamus doesn't make enough hormones. In addition I take 50 mcg vaginal tablet once a week - it shrank my clitoris! I also take a small dose of testosterone but the estradiol seems to overpower that. My libido is still gone."