seizures
"I have been on many anti-epileptic medicines over the course of 30  years: Dilantin, Mysoline, Klonopin, Depakote, Topamax, Lamictal, etc. While Keppra did a good job of controlling the myoclonic jerks which I often experience, it was way too sedating when combined with Topamax. It wasn't uncommon for me to sleep twelve hours a day. 

The real problem with Keppra was the mood swings, depression, anger and suicidal thoughts. It's no secret that a link exists between epilepsy/seizure disorders and some (all) of these issues; however, in my case these feelings and emotions definitely intensified while taking Keppra."