constipation, chronic
"Linzess 290 only worked for 3 days then I went right back to chronic constipation.  I continued to take it for about 2 months nevertheless.  No results.  I had terrible side effects -- bloating and cramps. Eventually turned back to old fashioned laxatives out of desperation. I'm still suffering from chronic constipation til today.  Change in diet and exercise has had no effect."