postmenopausal symptoms
"I've been using the estradiol patch for about a year. I just went from 0.025/mg weekly to 0.025/mg twice weekly. I have gotten several different forms (large round, regular clear, small clear) of the patch and have never had a problem with patches not adhering to my skin. The adhesive residue comes off with cotton ball and alcohol. You CANNOT use any lotion, cream or oil on the area where the patch is used. 
I did have to increase my dose because my symptoms took a spike, but the patch works well once about two weeks after starting."