barrett's esophagus
"I was on Prilosec for about 9 years for acid reflux. For me it was a miracle drug that gave me relief for acid reflux.  My dosage was continually increased till I was taking 4 20mg pills a day (probably a problem with my acid reflux increasing).  After having more problems, I had an endoscopy which showed I had Barrett's Esophagus.  I was prescribed Protonix (2 x 40mg pills/day).  So far Protonix has worked great.  For me it works better than the Prilosec did."