motion sickness
"I have tried meclazine as a prophylactic to motion sickness while fishing in the Gulf of Mexico with mixed results. 

The first time out was a complete failure with severe nausea and vomiting accompanied by diarrhea. The second time was a little better, no diarrhea and limited vomiting but quite acute nausea. 
Won't use it again for this purpose, probably won't go out on the gulf anytime soon either,

No noticeable side effects with either event."