tourette's syndrome
"After 3 days of taking Clonidine (50mcg twice a day) I can't bare to continue. I've had little to no relief from my tics and the side effects surely outweigh any minor benefit. 

Side effects have included: dry mouth, increased thirst, irritable, mood swings, extreme feelings of anger, constipation, nausea, drowsiness, nightmares, feeling like I'm in a constant almost disassociated state, and dizziness.

My vocal tics before starting this medication were generally only at a normal speaking level of voice and I could usually tell when I was about to tic but they have increased to loud yelling with little or no premonitory urge.
I would like to have tried this drug for longer but due to the side effects I will not be continuing it."