abnormal uterine bleeding
"I'm reading all these reviews and I'm puzzled.  I've been on Depo for nearly 17 years, with a few breaks and this month is the first time I've ever even spotted.  I've never had a period or cramping the rest of the time I've been on it.  I do think it's attributed to some minor weight gain.  I'm actually wondering if there was a bad batch of this out out within the last year, considering all these reviews about bleeding are so recent?"