pain
"I've been on fentanyl patches for a couple of years - 150 (100   50) for degenerative disc disease and in the past few months they have been working less well, starting about 22 hours into the 2nd day (so, almost at day 3).  The 3rd day is the worst and it's almost (not quite) as bad as what happens if I forgot to change it on the 3rd day (which only happened once or twice!)  Apparently the medicines are just running out and I start feeling more nauseous and exhausted, and my arms feel like they are going to fall off (I don't normally have pain in my arms.)

The pain relief on day #1 is outstanding and I get all my housework, chores done, and spend lots of time being ACTIVE with my kids on day 1."