depression
"Took it for about 2 years - get ready for weight gain, loss of interest in everything, extreme tiredness, zero interest in sex. Sure, my "depression" symptoms felt a little better (but would have had at least the same result with healthy diet and exercise). It took the "bad feelings" away, but it also took the "good feelings" away. When I weened off Pristiq, every five seconds I felt like an electric shock in my brain (that's the best I can describe the feel) it was the worst 2-3 weeks of my life."