depression
"I sometimes have mood problems, which I believe are related to blood sugar issues because when I am careful to not consume refined sugars, I feel much better. I also experience joint pain because of the decades of physical labour.

I have been taking SAMe for more than 15 years, 200 mg every morning before breakfast.

It affects me in a subtle way, It seems to pick my mood up a bit. I can't take it at night before I go to bed because it makes my brain overactive and I can't sleep.

Lately, I've been searching the Internet for information about the long term side effects because I am a little worried about taking this substance regularly for such an extended period of time. The dosage is low (200 mg daily), but still, 15 years is a long time"