constipation, chronic
"I can truly say this medication has changed my life!  I have had years of constipation and used suppositories and Mirilax on a regular basis.  Other oral medications were too harsh and cause me to throw up.  I tried Linzess a year go and I didn't give myself enough time to adjust to the medication, lots of diarrhea.  But my doctor encouraged me to try again and commit to it for a few weeks.  Sure enough the side effects tapers off and things are mostly regular .  It is very expensive and my doctor had to go through hoops to get the medication approved by my insurance."