 Additional patients dosed in RDEB, MPS IIIA and MPS IIIB clinical programs General alignment with CHMP on plans for EU registration of ABO-102 for MPS IIIAData from RDEB and MPS III programs presented at recent medical meetingsStrengthened leadership team with appointment of experienced Chief Commercial Officer and two independent Board members Conference call on Tuesday, August 11, 2020 at 8:30 a.m. ETNEW YORK and CLEVELAND, Aug. 10, 2020 GLOBE NEWSWIRE -- Abeona Therapeutics Inc. Nasdaq: ABEO, a fully-integrated leader in gene and cell therapy, today announced financial results for the second quarter 2020 and recent business progress.During the past several months, Abeona has delivered on our goals in clinical development, manufacturing, and regulatory affairs toward bringing urgently needed treatments to patients with RDEB and MPS III, said João Siffert, M.D., Chief Executive Officer of Abeona. Notably, new patients have been treated in our RDEB and MPS IIIA clinical programs, and we expect additional patient enrollment across our clinical programs in the coming weeks. Concurrent with the increased clinical activities, we resumed internal manufacturing operations at our Cleveland campus in June. We have made significant advancements in process development for retrovirus and AAV manufacturing in-house, anticipated to start in late-2020 and early-2021, respectively. In addition, we recently reached general alignment with the CHMP on our proposed path toward a European marketing authorization application for ABO-102 in MPS IIIA, anticipated in 2023. Looking ahead to the potential commercial launches of EB-101 in late-2022 and ABO-102 the following year, we have also strengthened our leadership team, bringing on board a Chief Commercial Officer with significant relevant experience and expertise.Second Quarter and Recent HighlightsEB-101 Autologous, Gene-Corrected Cell Therapy A second patient was treated in Abeonas EB-101 pivotal Phase 3 VIITALTM study for recessive dystrophic epidermolysis bullosa RDEB after enrollment resumed in June 2020 following a pause due to the COVID-19 pandemic. Additional patients are expected to be treated in the coming weeks, with completion of enrollment in the VIITAL study expected in early-2021. Two posters were presented at the Society for Pediatric Dermatology 45th Annual Meeting. The first poster highlighted data showing that EB-101 treatment of large RDEB wounds resulted in up to five years of durable healing, which was associated with long-term pain relief. A separate poster characterized the significant disease burden of RDEB on patients and their families.ABO-102 and ABO-101 AAV-based Gene Therapies In July 2020, Abeona held a kick-off meeting under the European Medicines Agencys EMA PRIority MEdicines PRIME program, which included members of the Committee for Advanced Therapies CAT and the Committee for Medicinal Products for Human Use CHMP of the EMA. The Company presented its plan toward registration of ABO-102 for MPS IIIA Sanfilippo syndrome type A, taking advantage of the PRIME designation that offers a path for accelerated assessment of promising therapies targeting unmet medical needs. Based on the PRIME meeting, along with previous input from the CHMP and the Pediatric Committee PDCO of the EMA, Abeona anticipates submitting a marketing authorization application for EU conditional approval of ABO-102 for MPS IIIA in 2023. The Company continues to seek guidance from the FDA on the U.S. regulatory path for ABO-102 in MPS IIIA, but acknowledges that the FDA is currently focused on matters related to COVID-19 and other life-threatening conditions, as reflected in its issued guidance in May 2020. Total enrollment to date in the ABO-102 Transpher A study for MPS IIIA is 17 patients, including 11 patients dosed in cohort 3. Total enrollment to date in the ABO-101 Transpher B study for MPS IIIB Sanfilippo syndrome type B is 9 patients, including 2 patients dosed in cohort 3. Abeona anticipates completing enrollment in both the Transpher A and Transpher B studies by the end of 2020. Updated positive interim data from the Transpher A and Transpher B studies were presented at the American Society of Gene Cell Therapy 23rd Annual Meeting. The findings support previously reported data showing preservation of neurocognitive skills among three young patients treated in dose cohort 3 of the Transpher A study. Improvements in multiple disease-specific biomarkers, denoting clear biologic effects, and a favorable safety profile in MPS IIIA and MPS IIIB patients after treatment with ABO-102 and ABO-101, respectively, were observed in both studies.Manufacturing Activities In June 2020, Abeona fully resumed operations at its state-of-the-art GMP manufacturing facility in Cleveland, Ohio, manufacturing EB-101 drug product for the Phase 3 VIITALTM study. The Company initiated process development at the facility that will enable production of the retrovirus used for EB-101 manufacture, allowing for increased control of the supply chain and product quality, as well as reduced costs. Abeona also resumed process development activities to enable in-house manufacturing of commercial supply of ABO-101 and ABO-102.Corporate Update The Company further strengthened its leadership team with the appointment of Michael Amoroso as Chief Commercial Officer, and the addition of George Migausky and Paul Mann as independent members of its Board of Directors. In addition to their Board service, Mr. Migausky serves as Chairman of the Companys Audit Committee and Mr. Mann serves as a member of the Audit Committee.Second Quarter Financial ResultsCash, cash equivalents and short-term investments totaled 107.9 million as of June 30, 2020, compared to 129.3 million as of December 31, 2019. Net cash used in operating activities was 9.5 million for the second quarter 2020.Research and development RD spending was 6.1 million for the second quarter of 2020 and 12.9 million for the six months ended June 30, 2020, compared to 16.3 million and 28.0 million in the comparable periods in 2019. The decrease in RD expenses was primarily due to decreased manufacturing, clinical and non-clinical development activities arising from the effects of the COVID-19 pandemic, and cost savings associated with the decision to internally manufacture retrovirus for the EB-101 program.General and administrative GA expenses were 5.5 million for the second quarter of 2020 and 12.0 million for the six months ended June 30, 2020, compared to 5.6 million and 11.3 million in the comparable periods in 2019. The increase in GA expenses for the six months ended June 30, 2020 was largely due to increases in salary and related costs partially offset by decreased professional fees.Net loss was 13.0 million for the second quarter of 2020 and 61.2 million for the six months ended June 30, 2020, compared to net loss of 23.9 million and 42.5 million for the comparable periods in 2019.Conference Call DetailsAbeona Therapeutics will host a conference call and webcast tomorrow, Tuesday, August 11, 2020 at 8:30 a.m. ET, to discuss its second quarter 2020 financial results and provide an update on the companys business. To access the call, dial 844-369-8770 U.S. toll-free or 862-298-0840 international and provide conference ID 18965539 five minutes prior to the start of the call. A live, listen-only webcast and archived replay of the call can be accessed on the Investors Media section of Abeonas website at The archived webcast replay will be available for 30 days following the call.About Abeona Therapeutics Abeona Therapeutics Inc. is a clinical-stage biopharmaceutical company developing gene and cell therapies for serious diseases. Abeonas clinical programs include EB-101, its autologous, gene-corrected cell therapy for recessive dystrophic epidermolysis bullosa in Phase 3 development, as well as ABO-102 and ABO-101, novel AAV-based gene therapies for Sanfilippo syndrome types A and B MPS IIIA and MPS IIIB, respectively, in Phase 12 development. The Companys portfolio of AAV-based gene therapies also features ABO-202 and ABO-201 for CLN1 disease and CLN3 disease, respectively. Abeonas novel, next-generation AIMTM capsids have shown potential to improve tropism profiles for a variety of devastating diseases. Abeonas fully functional, gene and cell therapy GMP manufacturing facility produces EB-101 for the pivotal Phase 3 VIITALTM study and is capable of clinical and commercial production of AAV-based gene therapies. For more information, visit Forward-Looking Statements This press release contains certain statements that are forward-looking within the meaning of Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended, and that involve risks and uncertainties. These statements include statements about the Companys clinical trials and its products and product candidates, future regulatory interactions with regulatory authorities, as well as the Companys goals and objectives. We have attempted to identify forward looking statements by such terminology as may, will, believe, estimate, expect, and similar expressions as well as other words or expressions referencing future events, conditions or circumstances, which constitute and are intended to identify forward-looking statements. 