 WILMETTE, Ill. and BELOIT, Wis. and MORGAN HILL, Calif., Aug. 19, 2020 GLOBE NEWSWIRE -- Monopar Therapeutics Inc. Nasdaq: MNPR Wilmette, IL and NorthStar Medical Radioisotopes, LLC Beloit, WI, who are collaborating on the development of urokinase plasminogen activator receptor targeted radio-immuno-therapeutics uPRITs for the potential treatment of patients with severe COVID-19, today announced a partnership with Aragen Bioscience, Inc. Morgan Hill, CA, a leading contract research organization focused on accelerating preclinical biologics product development. Aragen will perform studies aimed at selecting a lead candidate uPRIT to advance into IND-enabling development for severe COVID-19. Aragens expertise in this specific area of preclinical research should accelerate selection of a lead uPRIT based on the MNPR-101 antibody scaffold to advance toward the clinic, said Andrew Mazar, PhD, Chief Scientific Officer of Monopar.We are pleased to partner with Aragen on this important phase of the uPRIT program, said James T. Harvey, PhD, Senior Vice President and Chief Science Officer of NorthStar. Using rigorous criteria to select the uPRIT candidate to advance into IND-enabling studies is a crucial part of our COVID-19 program.uPRIT has great therapeutic potential for severe COVID-19 patients, said Axel Schleyer, PhD, MBA, Chief Executive Officer of Aragen. We are excited to partner with Monopar and NorthStar on this important endeavor.The aim of this partnership is to identify the uPRIT with the optimal urokinase plasminogen activator receptor binding profile, enabling selective delivery of a cytotoxic radioisotope to just those aberrantly activated immune cells that produce the cytokine storm that causes severe lung injury, multiple organ damage, and death in severe COVID-19 patients.About Monopar Therapeutics Inc. Monopar Therapeutics is a clinical-stage biopharmaceutical company primarily focused on developing proprietary therapeutics designed to extend life or improve the quality of life for cancer patients. Monopars pipeline consists of Validive for the prevention of chemoradiotherapy-induced severe oral mucositis in oropharyngeal cancer patients; camsirubicin for the treatment of advanced soft tissue sarcoma; and a late-stage preclinical antibody, MNPR-101, for advanced cancers and severe COVID-19. For more information, visit: NorthStar Medical Radioisotopes, LLC NorthStar Medical Radioisotopes is a global innovator in the production and distribution of radioisotopes used for medical imaging and therapeutic purposes. NorthStar is a company committed to providing the United States with reliable and environmentally friendly radioisotope supply solutions to meet the needs of patients and to advance clinical research. The Companys first product is the RadioGenix System technetium Tc 99m generator, an innovative and flexible platform technology initially approved by the U.S. Food and Drug Administration in February 2018. For more information, visit: Aragen Bioscience, Inc. Aragen Bioscience, Inc., a wholly owned subsidiary of GVK BIO, is a leading contract research organization based in the San Francisco Bay Area. Aragen Bioscience offers a diverse set of in vitro and in vivo services for the discovery, cell line development, production, characterization, activity and efficacy assessment and development of biologic and diagnostic products. For more information, visit: Statements Statements contained in this press release regarding matters that are not historical facts are forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. The words may, will, could, would, should, expect, plan, anticipate, intend, believe, estimate, predict, project, potential, continue, target and similar expressions are intended to identify forward-looking statements, although not all forward-looking statements contain these identifying words. Examples of these forward-looking statements include statements concerning Aragens ability to select a lead candidate uPRIT, based on the MNPR-101 antibody scaffold, into IND-enabling development and toward the clinic for severe COVID-19, that uPRIT has great therapeutic potential for severe COVID-19 patients, and the partnerships ability to identify the uPRIT with the optimal binding profile that enables selective delivery of a cytotoxic radioisotope to just those aberrantly activated immune cells that produce the cytokine storm that causes severe lung injury, multiple organ damage, and death in severe COVID-19 patients. The forward-looking statements involve risks and uncertainties including, but not limited to, the lack of any clinical activities to date with respect to MNPR-101, the requirement for additional capital to complete preclinical and clinical development, potential for commercialization, not being able to couple MNPR-101 to a therapeutic radioisotope, the conjugate not being able to kill aberrantly activated cytokine-producing immune cells, the conjugate not being able to use uPAR to gain entry into these cells and release this cytotoxic payload to kill these cells while sparing normal tissue, not being able to ensure volumes of this radioisotope can be manufactured and scaled up to meet potential demand, uncertainties about levels of demand if and when a treatment is available for commercialization and the significant general risks and uncertainties surrounding the research, development, regulatory approval and commercialization of therapeutics. Actual results may differ materially from those expressed or implied by such forward-looking statements. Risks are described more fully in Monopars filings with the Securities and Exchange Commission. All forward-looking statements contained in this press release speak only as of the date on which they were made. Monopar, NorthStar and Aragen undertake no obligation to update such statements to reflect events that occur or circumstances that exist after the date on which they were made. Any forward-looking statements contained in this press release represent Monopars, NorthStars, and Aragens views only as of the date hereof and should not be relied upon as representing its views as of any subsequent date.CONTACTS:For Monopar Therapeutics Inc.: Investor Relations: Kim R. Tsuchimoto Chief Financial Officer NorthStar Medical Radioisotopes, LLC.: Investor Relations: Paul Estrem Senior Vice President and Chief Financial Officer Aragen Bioscience, Inc.: David Lustig 