 The FDA has granted Orphan Drug Designation to Aldeyra Therapeutics Incs NASDAQ: ALDX ADX-2191 methotrexate for intravitreal injection for primary vitreoretinal lymphoma PVRL. PVRL is a rare ocular lymphoid malignancy consisting of a subset of primary central system lymphoma PCNSL and the most common type of intraocular lymphoma. 