 Shares in AC Immune ACIU are surging 56 in Thursdays pre-market trading after the biopharma announced the initiation of the second highest dosing group in the its Phase 1b2a clinical trial evaluating ACI-35.030 for the treatment of Alzheimers disease AD.The decision to advance to the higher dosing group follows encouraging interim safety, tolerability and immunogenicity results from the initial dosing group.Immunization with anti-Tau vaccines has become an important strategy for the treatment of AD and other neurodegenerative diseases characterized by Tau pathology, says AC Immune.ACI-35.030, which is being developed in collaboration with Johnson Johnsons JNJ Janssen Pharmaceuticals, Inc., is the first AD vaccine candidate designed to generate a specific antibody response against pathologic phospho-Tau pTau proteins in the brain. This can potentially reduce the spread and seeding of Tau pathology throughout the brain.Prof. Andrea Pfeifer, CEO of AC Immune SA, commented: The fact that ACI-35.030 shows encouraging safety and immunogenicity at the lowest dose in this elderly patient population is highly meaningful and we look forward to quickly enrolling this next dosing group.She continued: Tau-targeted approaches may have a much broader therapeutic window to potentially disrupt, slow or prevent disease progression at both early and advanced disease stages. Pathological pTau occurs early in the disease process, years before accumulation of Tau deposits. Therefore, our pTau-targeting approach holds significant promise for the treatment of AD at different disease stages.This Phase 1b2a trial is a randomized, multicenter, double-blind, placebo-controlled clinical study with a primary objective to assess the safety, tolerability and immunogenicity of different doses of ACI-35.030 over a 48-week treatment phase in 24 patients with early AD. Other endpoints will assess clinical and cognitive parameters as well as additional immunogenicity and safety parameters.Alzheimers disease is a devastating neurodegenerative disease of the central nervous system which is responsible for 60-80 of all cases of dementia and progressively destroys the cognitive abilities of those who develop the disease.HC Wainwright analyst Andrew Fein has a buy rating on ACIU with an 11 price target 53 upside potential. We believe a disconnect remains for fully appreciating AC Immunes AD platform as reflected by its market capitalization, which we believe can be realized as upside following potentially validating data anticipated later this year he commented on July 9. See ACIU stock analysis on TipRanksRelated News: Boston Scientific Mulls Billion-Dollar Snake Venom Sale- Report Becton, Dickinson Score Fed Contract For Covid-19 Rapid Test Systems Akebia Initiates Vadadustat Study In Covid-19 Patients More recent articles from Smarter Analyst: Tesla Car Registrations In California Sink 48 in Q2 - Report Novartis To Sell Covid-19 Drugs At Zero-Profit To Low-Income Countries Zoom Launches Its Own Video-Conferencing Hardware For In-Home Use Google Shifts Business Apps To Accommodate Stay-At-Home Workforce 