 Approximately 85 of Clinicians Surveyed Likely to Prescribe Oral Parathyroid Hormone PTH to Treat Moderate to Severe Osteoporosis Oral PTH Described by Clinicians as Potential Game-Changer that Addresses Substantial Unmet Need with Possibility of Improving Patient Compliance and Comfort Potential to Significantly Expand the Multi-Billion Dollar Global Market; More than Half of Clinicians Likely to Increase Usage of PTH to Treat Osteoporosis if an Effective Orally Delivered Product is Available BOSTON and JERUSALEM, July 22, 2020 GLOBE NEWSWIRE -- Entera Bio Ltd. NASDAQ: ENTX, a leader in the development of orally delivered large molecule therapeutics, announced today the results from two primary market research studies of clinicians who treat osteoporosis patients. The studies were conducted by a third-party firm with a goal of gaining a better understanding of the perceived value and potential market penetration of an orally-delivered parathyroid hormone product in the treatment of osteoporosis. The survey populations were comprised of clinicians who frequently prescribe osteoporosis products including endocrinologists, gynecologists, orthopedists, and general practitioners, with over 70 of their osteoporosis patients having moderate to severe osteoporosis. One study surveyed clinicians in the U.S., Canada, and Europe, and the second surveyed clinicians in Japan. In the two studies, physicians were presented with a description of an oral PTH product that provides similar efficacy and safety of injectable PTH without the need for daily subcutaneous injections. The responses to the prospect of prescribing an oral PTH were overwhelmingly positive, driven by expected improvements in patient compliance, ease of administration, and without injection site discomfort. Physicians also considered reduced costs to patients and payers to be important features. Enteras EB613 oral PTH is currently in Phase 2 clinical development for the treatment of osteoporosis, a multi-billion dollar global market.We are very pleased with the data from this important global market survey which very clearly validates the value proposition of our lead drug candidate, EB613. Due to the high cost, inconvenience, and pain associated with injectable osteoanabolic products, which are currently the standard of care for treating moderate to severe osteoporosis, it is estimated that only 5 of patients with severe osteoporosis actually receive treatment for their disease, stated Entera CEO Adam Gridley. The results of this market analysis confirm Enteras view that an oral PTH tablet meets an unmet physician and patient need and can potentially grow the number of patients receiving treatment. Remarkably, approximately 45 of the participating physicians indicated the oral PTH would be their first line treatment choice for their patients with severe osteoporosis.The study conducted in the U.S.CanadaEurope included 100 clinicians with roughly 80 of the respondents from North America and 20 from Europe. Two-thirds of the clinicians were rheumatologists or endocrinologists with the balance equally split between orthopedists and general practitioners. The study conducted in Japan included 75 clinicians, approximately three-fourths of which were orthopedists. In both studies, patients treated by the physicians were predominantly female, and by progression of disease, the distribution of the patients was approximately 21 with earlymild osteoporosis, approximately 48 with moderate osteoporosis, and approximately 31 with severe osteoporosis. Clinicians in both studies were in general agreement that a safe and effective oral PTH may greatly reduce the use of PTH injectables for the treatment of osteoporosis, drastically changing the market by increasing patient comfort and compliance. Key findings from the physician surveys included: United States and Europe n100Japan n75 Oral PTH as preferred method of treatment for severe osteoporosis patients relative to other options5857 Likely to prescribe oral PTH treatment for osteoporosis8489 Likely to increase prescribing levels for Osteoporosis patients if an effective oral PTH treatment is available5678 Oral PTH is compelling7981 s are those clinicians with a positive response to using an oral PTH product that could provide similar efficacy and safety of injectable PTH Dr. Arthur Santora, Enteras Chief Medical Officer, added, A majority of clinicians stated the availability of an oral PTH with the attributes presented to them would grow their practice and some of the clinicians surveyed summed things up succinctly when they stated an oral PTH would be a game changer. The data show the potential of an oral PTH to have a transformative impact on the treatment of osteoporosis by serving as a possible first line therapy, enabling doctors to treat patients with moderate to severe osteoporosis who are currently untreated by offering a much needed alternative to needle-phobic and cost-constrained patients. We believe the promising feedback from physicians currently involved in the care of high fracture risk patients with current osteoporosis medications may result in a rapid market adoption of the first oral PTH product. Our goal is for Entera Bios EB613 oral PTH to be that product. We expect to complete patient enrollment in our Phase 2 study of EB613 in the third quarter of 2020 with a goal of moving into Phase 3 by late 2021 or 2022. About Entera Bio Ltd.Entera is a leader in the development of orally delivered macromolecule therapeutics for use in areas with significant unmet medical need where adoption of injectable therapies is limited due to cost, convenience and compliance challenges for patients. The Companys proprietary, oral drug delivery technology is designed to address the technical challenges of poor absorption, high variability, and the inability to deliver large molecules to the targeted location in the body through the use of a synthetic absorption enhancer to facilitate the absorption of large molecules, and protease inhibitors to prevent enzymatic degradation and support delivery to targeted tissues. The Companys most advanced product candidates, EB613 for the treatment of osteoporosis and EB612 for the treatment of hypoparathyroidism are in Phase 2 clinical development. Entera also licenses its technology to biopharmaceutical companies for use with their proprietary compounds and, to date, has established a collaboration with Amgen Inc. For more information on Entera Bio, visit Looking StatementsVarious statements in this release are forward-looking statements under the securities laws. Words such as, but not limited to, anticipate, believe, can, could, expect, estimate, design, goal, intend, may, might, objective, plan, predict, project, target, likely, should, will, and would, or the negative of these terms and similar expressions or words, identify forward-looking statements. Forward-looking statements are based upon current expectations that involve risks, changes in circumstances, assumptions and uncertainties. Forward-looking statements should not be read as a guarantee of future performance or results and may not be accurate indications of when such performance or results will be achieved. 