 New contraindication applies to a subset of patients with primary biliary cholangitis PBC with decompensated cirrhosis, a prior decompensation event, or with compensated cirrhosis who have evidence of portal hypertension New contraindication applies to a subset of patients with primary biliary cholangitis PBC with decompensated cirrhosis, a prior decompensation event, or with compensated cirrhosis who have evidence of portal hypertension 