 Completed Enrollment for HST-001 Phase 1a2b Trial for Androgenic Alopecia in Men with Topline Data Expected 4Q20 Filed IDE for HST-002 for Treatment of Moderate to Severe Nasolabial Folds Appointed Susan A. Knudson as Chief Financial OfficerSAN DIEGO, Aug. 13, 2020 GLOBE NEWSWIRE -- Histogen Inc. NASDAQ: HSTO, a clinical-stage therapeutics company focused on developing potential first-in-class restorative therapeutics that ignite the bodys natural process to repair and maintain healthy biological function, today reported financial results for the second quarter ended June 30, 2020 and provided an update on its clinical pipeline and other corporate developments.Key Second Quarter 2020 Highlights and Subsequent Updates Filed Investigational Device Exemption IDE for HST-002. In April, Histogen filed an IDE application with the U.S. Food and Drug Administration FDA for the initiation of a Phase 1 clinical trial of HST-002 as a dermal filler for the treatment of moderate to severe nasolabial folds. If the application is approved, Histogen plans to initiate the clinical trial in fourth quarter of 2020. Closed Reverse Merger with Conatus. In May, Histogen closed the reverse merger transaction with Conatus. The transaction included approximately 13.0 million in cash resources, which when combined with existing resources, is expected to fund Histogens current operating plan into the second quarter of 2021. The combined company changed its name from Conatus Pharmaceuticals Inc. to Histogen Inc. and began trading on the Nasdaq Capital Market under the ticker symbol HSTO on May 27, 2020. Appointed Susan A. Knudson as Chief Financial Officer. In May, Ms. Knudson joined Histogen as its Executive Vice President and Chief Financial Officer. With over 20 years of experience in the biopharmaceutical industry, she brings a wealth of financial and corporate strategy expertise to Histogen. Ms. Knudson most recently served as Chief Financial Officer at Pfenex Inc. and prior to Pfenex, she held the position of Chief Financial Officer of Neothetics, Inc. Completed Enrollment for HST-001 Phase 1a2b trial for Androgenic Alopecia in Men with Topline Data Expected in the fourth quarter 2020. Histogen announced that it initiated the trial in June, completed enrollment in July and expects to report topline results in the fourth quarter of 2020. Entered into Common Stock Purchase Agreement for Up to 10 Million. In July, Histogen entered into a common stock purchase agreement for up to 10 million with Lincoln Park Capital Fund, LLC. Upon execution of the purchase agreement, Lincoln Park made an initial purchase of 1.0 million of common stock. Throughout the second quarter of this year, we focused on transforming Histogen into a leading restorative therapeutics development company through the completion of the reverse merger, obtaining a NASDAQ listing, strengthening the executive team and advancing our innovative therapeutics pipeline, said Richard W. Pascoe, Histogens President and Chief Executive Officer. In the remaining months of 2020, we will focus on achieving a number of near-term clinical and regulatory value-inflection points, such as filing an IND for our HST-003 program focused on knee cartilage repair, initiating a Phase 1 trial for HST-002 for the treatment of moderate to severe nasolabial folds and reporting topline results from our HST-001 Phase 1a2b trial for androgenic alopecia in men. Moreover, I want to take this opportunity to commend the entire Histogen team for their tireless efforts, in the midst of a global pandemic, to position the company for success in 2020 and beyond.Expected Second Half 2020 Milestones Submit HST-003 IND for the regeneration of cartilage in the knee Initiate HST-002 Phase 1 trial for the treatment of moderate to severe nasolabial folds, if IDE is approved Report topline data for HST-001 Phase 1a2b trial for androgenic alopecia in menFinancial Highlights for the Second Quarter 2020Revenues for the three months ended June 30, 2020 and 2019 were 0.1 million and 1.4 million, respectively. The year-over-year decrease of 1.3 million was primarily due to a decrease in the fulfillment of supply orders of CCM to Allergan and one additional customer.Cost of revenues for the three months ended June 30, 2020 and 2019, were 0 million and 0.5 million, respectively. The decrease of 0.5 million for the three months ended June 30, 2020 as compared to the three months ended June 30, 2019 was due to a decrease in fulfillment of supply orders of CCM to Allergan and one additional customer.For both the three months ended June 30, 2020 and 2019, we recognized costs of professional services of 0.1 million related to our Allergan License Agreements.In-process research and development expenses for the three months ended June 30, 2020 and 2019 were 7.1 million and 2.3 million, respectively. In the three months ended June 30, 2020, we incurred 7.1 million for in-process research and development acquired in connection with the reverse merger with Conatus and in the three months ended June 30, 2019, we incurred 2.3 million for in-process research and development related to the acquisition of HST-003 and HST-004 from PUR Biologics LLC.Research and development expenses for the three months ended June 30, 2020 and 2019 were 1.4 million and 1.0 million, respectively. The increase of 0.4 million for the three months ended June 30, 2020 was primarily due to an increase in development costs for our product candidates.General and administrative expenses for both the three months ended June 30, 2020 and 2019 were 1.6 million. The three months ended June 30, 2019 included success-based fees of approximately 0.8 million related to 7.5 million of license revenue received in the three months ended June 30, 2019 for which there was no comparable expense incurred in the three months ended June 30, 2020. This decrease for the three months ended June 30, 2020 was offset by increases in personnel related expenses, legal and accounting fees in the three months ended June 30, 2020.Cash and cash equivalents as of June 30, 2020 were 10.4 million. Histogen believes that its existing cash and cash equivalents and cash inflow from operations will be sufficient to meet Histogens anticipated cash needs into the second quarter of 2021.About Histogen Inc.Histogen Inc. is a clinical-stage therapeutics company focused on developing potential first-in-class restorative therapeutics that ignite the bodys natural process to repair and maintain healthy biological function. Histogens innovative technology platform utilizes cell conditioned media and extracellular matrix materials produced by hypoxia-induced multipotent cells. Histogens proprietary, reproducible manufacturing process provides targeted solutions across a broad range of therapeutic indications including hair growth, dermal rejuvenation, joint cartilage regeneration and spinal disk repair. For more information, please visit StatementsThis press release contains forward-looking statements within the meaning of the safe harbor provisions of the Private Securities Litigation Reform Act of 1995 and other Federal securities laws. For example, we are using forward-looking statements when we discuss Histogens future operations and its ability to successfully initiate and complete clinical trials, obtain clinical trial data, and achieve regulatory milestones and related timing, including those related to the submission of a HST-003 IND for regeneration of cartilage in the knee, the initiation of a HST-002 Phase 1 trial for the treatment of moderate to severe nasolabial folds and the reporting of topline data for the ongoing HST-001 Phase 1a2b trial for androgenic alopecia in men; the nature, strategy and focus of Histogens business; the sufficiency of Histogens cash resources and Histogens ability to achieve value for its stockholders; and the development and commercial potential and potential benefits of any of Histogens product candidates, such as HST-001, HST-002 and HST-003. Histogen may not actually achieve the plans, carry out the intentions or meet the expectations or projections disclosed in the forward-looking statements and you should not place undue reliance on these forward-looking statements. Because such statements deal with future events and are based on Histogens current expectations, they are subject to various risks and uncertainties and actual results, performance or achievements of Histogen that could differ materially from those described in or implied by the statements in this press release, including: the uncertainties associated with the clinical development and regulatory approval of Histogens product candidates, including potential delays in the commencement, enrollment and completion of clinical trials, such as the planned HST-002 Phase 1 trial for the treatment of moderate to severe nasolabial folds and the reporting of topline data for the ongoing HST-001 Phase 1a2b trial for androgenic alopecia in men; the potential that earlier clinical trials and studies of Histogens product candidates may not be predictive of future results; risks related to business interruptions, including the outbreak of COVID-19 coronavirus, which could seriously harm Histogens financial condition and increase its costs and expenses; and the requirement for additional capital to continue to advance these product candidates, which may not be available on favorable terms or at all. 