 Lead program ORIC-101 on track for multiple interim data readouts in 2021 and CD73 inhibitor ORIC-533 on track for IND filing in first half of 2021 Licensed exclusive worldwide development and commercialization rights to a potential best-in-class PRC2 inhibitor; IND filing expected in second half of 2021ORIC to host conference call today at 4:30 p.m. ETSOUTH SAN FRANCISCO, Calif. and SAN DIEGO, Aug. 05, 2020 GLOBE NEWSWIRE -- ORIC Pharmaceuticals, Inc. Nasdaq: ORIC, a clinical stage oncology company focused on developing treatments that address mechanisms of therapeutic resistance, today reported financial results for the quarter ended June 30, 2020.Since the beginning of the year, we have realized substantial progress advancing our wholly owned, internally developed pipeline, said Jacob Chacko, M.D., president and chief executive officer. Looking forward, we see a number of important events as we continue to execute against our strategic plans. We expect to select the recommended Phase 2 dose and initiate the expansion cohorts in both of our ongoing ORIC-101 clinical studies in the second half of the year. Additionally, we are preparing for the development of our newly licensed, potential best-in-class PRC2 inhibitor, ORIC-944, which along with ORIC-533, we anticipate as IND candidates for 2021.Second Quarter 2020 and Other Recent Highlights Licensed Exclusive Worldwide Rights to PRC2 Inhibitors: In August 2020, ORIC licensed exclusive worldwide development and commercialization rights to a potential best-in-class PRC2 inhibitor, ORIC-944, from Mirati Therapeutics, Inc. Under the terms of the agreement with Mirati, ORIC paid to Mirati a one-time non-cash payment of 20 million in shares of ORIC common stock. The number of shares issued was based on a price of 34.00 per share, representing a premium of 10 to the 60-day trailing volume weighted average trading price of ORICs common stock. ORIC is not subject to any future milestone or royalty payment obligations to Mirati. Preclinical Data on ORIC-101 Presented at AACR: In June 2020, ORIC presented three poster presentations at the 2020 American Association for Cancer Research AACR Annual Virtual Meeting II. Key findings of the presentations included: A transcriptional signature of glucocorticoid receptor GR activity was identified in a panel of 32 cell lines across triple negative breast cancer, non-small cell lung cancer and pancreatic ductal adenocarcinoma, which translated from preclinical models to human tumors; ORIC-101 overcame GR-mediated resistance to chemotherapeutic agents including taxanes, antimetabolites and platinum agents, in both in vitro and in vivo efficacy studies spanning a variety of solid tumors; and Transcriptional and histological profiling showed that ORIC-101 reversed GR-activated pathways involved in drug resistance and reversed in vivo markers of epithelial-to-mesenchymal transition, antiapoptosis, and hypoxia. Preclinical Data on CD73 Inhibitor Program Presented at AACR: In June 2020, ORIC presented two poster presentations at the 2020 AACR Annual Virtual Meeting II. Key findings of the presentations included: ORICs CD73 inhibitors demonstrated suppression of adenosine production in vitro across multiple cell types and rescued activation of CD8 T cells exposed to AMP with greater potency than competitor compounds; ORIC-533 was shown to result in sustained inhibition of adenosine production after drug washout, consistent with its slow off-rate, and differentiating from other CD73 inhibitors; ORIC-533 potency in high AMP environments distinguishes it from other compounds, with activity in AMP concentrations as high as 1 millimolar, which may better reflect certain tumor microenvironments; and Daily oral delivery of ORICs CD73 inhibitors significantly inhibited tumor growth, with corresponding in vivo reduction of adenosine levels in tumors, and immune modulation consistent with decreased immunosuppression. Expanded and Strengthened its Board: In June 2020, the company appointed Lori Kunkel, M.D., to its board of directors. Dr. Kunkel brings more than twenty-five years of experience in oncology and immunology drug development and commercialization. Completed 138 Million Initial Public Offering: On April 28, 2020, the company completed its initial public offering IPO, selling 8,625,000 shares of common stock, which included the full exercise by the underwriters of their option to purchase up to 1,125,000 additional shares, at 16.00 per share. Gross proceeds from the IPO, excluding underwriting discounts and commissions and other estimated offering costs, were 138.0 million.Anticipated Milestones ORIC expects to select the recommended Phase 2 dose for its two ongoing ORIC-101 combination trials in the second half of 2020 and to report interim data from one of the trials in the first half of 2021 and from the other trial in the second half of 2021. ORIC expects to file an Investigational New Drug IND Application for ORIC-533 with the Food and Drug Administration FDA in the first half of 2021. ORIC expects to file an IND Application for ORIC-944 with the FDA in the second half of 2021.Second Quarter 2020 Financial Results Cash and Cash Equivalents: Cash and cash equivalents totaled 196.6 million as of June 30, 2020, which includes the gross proceeds of 138.0 million from the companys IPO in April 2020. The company expects its current cash and cash equivalents will be sufficient to fund its current operating plan into the fourth quarter of 2022. RD Expenses: Research and development RD expenses were 7.7 million for the three months ended June 30, 2020, compared to 5.0 million for the three months ended June 30, 2019, an increase of 2.7 million. For the six months ended June 30, 2020, RD expenses were 15.0 million compared to 10.3 million for the same period of 2019, an increase of 4.7 million. The increases were primarily due to the continued advancement of the ORIC-101 and ORIC-533 programs and higher personnel and related expenses, including non-cash stock-based compensation. GA Expenses: General and administrative GA expenses were 3.4 million for the three months ended June 30, 2020, compared to 1.3 million for the three months ended June 30, 2019, an increase of 2.1 million. For six months ended June 30, 2020, general and administrative expenses were 5.3 million compared to 2.4 million for the same period in 2019, an increase of 2.9 million. These increases were primarily due to higher professional services and related costs to operate as a public company, and higher personnel costs, including non-cash stock-based compensation.Webcast and Conference Call ORIC will host a webcast and conference call today, August 5th, at 4:30 p.m. ET. To participate in the conference call, please dial 866 393-4306 domestic or 734 385-2616 international and refer to conference ID: 5167646. Please join the conference call at least 15 minutes early to register. A live webcast will be available in the Investors section of the companys website at The webcast will be archived for 60 days following the presentation.About ORIC Pharmaceuticals, Inc.ORIC Pharmaceuticals is a clinical stage biopharmaceutical company dedicated to improving patients lives by Overcoming Resistance In Cancer. ORICs lead product candidate, ORIC-101, is a potent and selective small molecule antagonist of the glucocorticoid receptor, which has been linked to resistance to multiple classes of cancer therapeutics across a variety of solid tumors. ORIC-101 is currently in two separate Phase 1b trials of ORIC-101 in combination with 1 Xtandi enzalutamide in metastatic prostate cancer and 2 Abraxane nab-paclitaxel in advanced or metastatic solid tumors. ORICs other product candidates include 1 ORIC-533, an orally bioavailable small molecule inhibitor of CD73, a key node in the adenosine pathway believed to play a central role in resistance to chemotherapy- and immunotherapy-based treatment regimens, and 2 ORIC-944, an allosteric inhibitor of the polycomb repressive complex 2 PRC2 via the EED subunit, being developed for prostate cancer. Beyond these three product candidates, ORIC is also developing multiple precision medicines targeting other hallmark cancer resistance mechanisms. ORIC has offices in South San Francisco and San Diego, California. For more information, please go to Note Regarding Forward-Looking StatementsThis press release contains forward-looking statements as that term is defined in Section 27A of the Securities Act of 1933 and Section 21E of the Securities Exchange Act of 1934. Statements in this press release that are not purely historical are forward-looking statements. Such forward-looking statements include, among other things, statements regarding ORICs development plans and timelines; the potential best-in-class nature of ORIC-944; plans underlying ORIC-101 clinical trials and development; the expected timing of reporting interim data from the ORIC-101 clinical trials; plans underlying ORIC-533, ORIC-944 or any other development programs; the planned filing of INDs for ORIC-533 and ORIC-944; the potential advantages of ORICs product candidates; the period over which ORIC estimates its existing cash and cash equivalents will be sufficient to fund its current operating plan; and statements by the companys president and chief executive officer. Words such as believes, anticipates, plans, expects, intends, will, goal, potential and similar expressions are intended to identify forward-looking statements. The forward-looking statements contained herein are based upon ORICs current expectations and involve assumptions that may never materialize or may prove to be incorrect. 