 Shares of Applied DNA Sciences Inc. APDN, 311.16 shot up 84.0 in premarket trading, after they more than quadrupled in the previous session up 311.2 in the wake of the biotechnology companys announcement that it had initiated a validation of a monkeypox virus test. The two day rally comes after the stock tied its record-low close of 68 cents on Aug. 1, after first setting that record low on July 25. 