 Accolade Inc. said late Thursday it has agreed to buy Innovation Specialists LLC, which does business as 2nd.MD, a leading expert medical opinion and medical decision support company based in Houston, for 460 million. The deal is expected to close by the end of February, and under the terms of the agreement, Accolade will pay 230 million in cash, 130 million in Accolade stock, and up to 100 million of Accolade stock payable upon certain revenue milestones after the closing. 