<prompt> Translate the following text to EnglishIngawa mbinu hii imesababisha maendeleo makubwa katika kuelewa jinsi matibabu yanavyofanya kazi, inaweza kuwa haiwezekani katika mazingira ya ulimwengu halisi ya idara ya dharura na inaweza kuzalisha masomo na uhalali mdogo wa nje.  <response>: While this approach has led to great strides in under-standing how treatment works, it may not be practical in the real-world setting of the emergency department and may generate studies with little external validity. 