<prompt> Translate the following text to EnglishWagonjwa wenye utegemezi mkubwa wana sehemu kubwa ya athari za matibabu zinazohusiana na pombe, lakini inakadiriwa kuwa wagonjwa kama hao hutokeza sehemu ndogo tu ya matatizo yote yanayohusiana na pombe.  <response>: Patients with severe dependence have a disproportionate share of alcohol-related medical consequences, but it is estimated that such patients generate only a fraction of all alcohol-related problems. 