<prompt> Answer this question truthfullyIn a chronic smoker who develops hypertension, hyperglycemia, and weight gain, what is the probable diagnosis?  <response>: <reason> The probable diagnosis is Cushings syndrome, which is a disorder that occurs when the body is exposed to high levels of cortisol hormone for an extended period of time. In chronic smokers, Cushings syndrome is often caused by the ectopic production of adrenocorticotropic hormone ACTH from a small cell lung cancer. Symptoms of Cushings syndrome may include hypertension high blood pressure, hyperglycemia high blood sugar, weight gain, muscle weakness, and mood changes. The treatment for Cushings syndrome depends on the underlying cause, and may include surgery, chemotherapy, radiation therapy, or medications to lower cortisol levels. 