<prompt> Answer this question truthfullyWhat condition is suggested by neuropathology showing spongiform degeneration and vacuole formation in grey matter structures e.g. caudate, putamen without inflammation?  <response>: <reason> Neuropathology showing spongiform degeneration and vacuole formation in grey matter structures e.g. caudate, putamen without inflammation is suggestive of Creutzfeldt-Jakob disease. 