<prompt> Answer this question truthfullyWhat lysosomal storage disease is identified by the presence of macrophages that resemble crumpled tissue paper?  <response>: <reason> Gaucher disease is the lysosomal storage disease that is characterized by macrophages resembling crumpled tissue paper. In Gaucher disease, a deficiency of the enzyme glucocerebrosidase leads to the accumulation of glucocerebroside in the bodys cells and tissues, including macrophages. These macrophages take on a distinctive appearance under the microscope, with a crumpled tissue paper-like appearance due to the accumulation of glucocerebroside. This is known as a Gaucher cell. The presence of Gaucher cells can help to confirm a diagnosis of Gaucher disease. 