<prompt> Answer this question truthfullyHow do Tyrosine Kinase inhibitors work to target downstream signaling pathways involved in growth, and what are the most important pathways that they target?  <response>: <reason> Tyrosine Kinase inhibitors work by targeting downstream signaling pathways involved in growth. The most important pathways that they target include: PI3KAkt, which leads to increased Bcl-2 expression anti-apoptosis; JAKSTAT, which wouldve led to increased cell proliferation; RasMAPK, which wouldve led to increased cell growth; and SrcFAK, which wouldve led to increased cell motility invasion and decreased cell adhesion migration. 