<prompt> Answer this question truthfullyWhat is the first step of heme synthesis, and what are the reactants, products, enzyme, and cofactor involved?  <response>: <reason> The first step of heme synthesis involves the combination of glycine and succinyl-CoA to form δ-aminolevulinic acid via the enzyme δ-aminolevulinic acid synthase, with vitamin B6 as a cofactor. 