<prompt> Answer this question truthfullyIn patients with acute STEMI, which intervention is most likely to improve cardiovascular and overall long-term mortality?  <response>: <reason> The restoration of coronary blood flow, such as through percutaneous coronary intervention PCI or fibrinolysis, is the intervention that is most likely to improve cardiovascular and overall long-term mortality in patients with acute ST-elevation myocardial infarction STEMI. 