<prompt> Answer this question truthfullyWhat combination drug is indicated in the treatment of Cystic Fibrosis for patients who have two copies of the F508del mutation in the CFTR gene?  <response>: <reason> In the treatment of Cystic Fibrosis, the combination drug lumacaftorivacaftor is indicated for patients who have two copies of the F508del mutation in the CFTR gene. 