<prompt> Answer this question truthfullyWhat are koilocytes and what is their significance in the diagnosis of infections?  <response>: <reason> Koilocytes are cells that have characteristic perinuclear halos, which are hallmarks of human papillomavirus HPV infections. HPV is a common sexually transmitted infection that can cause a variety of clinical manifestations, including genital warts, cervical cancer, and other types of cancer. The identification of koilocytes in a tissue sample is an important diagnostic feature of HPV infection and is used to guide clinical management and treatment. 