<prompt> Answer this question truthfullyWhat is the effect of handgrip on the murmur of hypertrophic cardiomyopathy?  <response>: <reason> The murmur of hypertrophic cardiomyopathy typically decreases with handgrip. This is because handgrip causes an increase in systemic vascular resistance, which leads to a decrease in the amount of blood that is able to flow through the left ventricular outflow tract. This decrease in blood flow results in a reduction in the intensity of the murmur, as there is less turbulence created by the blood flow obstruction. The decrease in murmur intensity with handgrip is a characteristic finding in hypertrophic cardiomyopathy and can be used as a diagnostic tool to differentiate it from other causes of left ventricular outflow tract obstruction. 