<prompt> Answer this question truthfullyWhat is the effect of Gitelman syndrome on serum Mg2 levels?  <response>: <reason> Gitelman syndrome is a genetic disorder that affects the function of the thiazide-sensitive sodium-chloride cotransporter in the kidneys, leading to increased sodium and chloride excretion and decreased magnesium reabsorption. As a result, individuals with Gitelman syndrome often experience decreased serum Mg2 levels hypomagnesemia, as well as hypokalemia and metabolic alkalosis. Treatment for Gitelman syndrome typically involves magnesium and potassium supplementation, as well as a low-sodium diet and thiazide diuretics to help manage symptoms. 