<prompt> Answer this question truthfullyWhat is the effect of the loss of the VHL tumor suppressor gene in renal cell carcinoma?  <response>: <reason> The loss of the VHL tumor suppressor gene in renal cell carcinoma leads to increased IGF-1, which promotes growth. The VHL gene is responsible for producing a protein that helps regulate cell growth and division. When this gene is mutated or lost, it can lead to the development of renal cell carcinoma, a type of kidney cancer. Loss of the VHL gene can also result in increased levels of insulin-like growth factor 1 IGF-1, which is a hormone that promotes cell growth and division. This can contribute to the growth and progression of renal cell carcinoma. 