<prompt> Answer this question truthfullyWhat are the symptoms of the late stage of Trypanosoma brucei infection sleeping sickness?  <response>: <reason> The late stage of Trypanosoma brucei infection sleeping sickness is characterized by CNS involvement and coma. Trypanosoma brucei is a parasitic infection that is transmitted by the tsetse fly and can lead to a variety of symptoms, including fever, headaches, joint pain, and fatigue. However, in the late stage of the disease, the parasite has crossed the blood-brain barrier and has invaded the central nervous system, leading to neurological symptoms such as confusion, seizures, and ultimately coma. 