<prompt> Answer this question truthfullyWhat are the symptoms associated with pyruvate dehydrogenase deficiency?  <response>: <reason> Pyruvate dehydrogenase deficiency presents with neurologic defects and lactic acidosis. This is because the lack of pyruvate dehydrogenase activity impairs the ability of the body to convert pyruvate to acetyl-CoA, leading to an accumulation of pyruvate and a subsequent increase in lactic acid production. The neurologic defects associated with this condition can include developmental delay, intellectual disability, seizures, and abnormal muscle tone. 