<prompt> Answer this question truthfullyIs there a significant risk of hemolytic disease of the newborn associated with maternal Lewis antibodies during pregnancy?  <response>: <reason> No, there is not a significant risk of hemolytic disease of the newborn associated with maternal Lewis antibodies during pregnancy. While Lewis antibodies can be present in some pregnant women, they are not typically associated with hemolytic disease of the newborn, which is a condition where a mothers antibodies attack and destroy her babys red blood cells. Instead, hemolytic disease of the newborn is most commonly associated with Rh incompatibility between the mother and baby, where the mother is Rh-negative and the baby is Rh-positive. In some cases, other blood group incompatibilities can also lead to hemolytic disease of the newborn, but these are generally less common than Rh incompatibility. 