<prompt> Answer this question truthfullyWhat is the effect of Liddle syndrome on serum K levels?  <response>: <reason> Liddle syndrome is a rare genetic disorder that affects the activity of epithelial sodium channels in the kidneys, leading to increased sodium reabsorption and potassium excretion. This can result in decreased serum K levels hypokalemia and metabolic alkalosis. Liddle syndrome is typically treated with medications that block the activity of epithelial sodium channels, such as amiloride or triamterene. 