<prompt> Answer this question truthfullyWhat type of genetic mutations may be associated with familial cases of ALS, and what is the result of these mutations?  <response>: <reason> What type of genetic mutations may be associated with familial cases of ALS, and what is the result of these mutations? Familial cases of ALS may be associated with zinc-copper superoxide dismutase 1 SOD1 mutations, which leads to free radical injury in neurons. 