<prompt> Answer this question truthfullyWhat are the two primary ways that resistance to Penicillins and their derivatives can occur, and what are the specific mechanisms behind each way?  <response>: <reason> The two primary ways that resistance to Penicillins and their derivatives can occur are: 1 mutations in Transpeptidases, which are enzymes involved in cell wall synthesis, and 2 production of β-lactamases, which are enzymes that can break down the β-lactam ring structure found in these antibiotics. 