<prompt> Answer this question truthfullyWhat gene mutation is responsible for familial melanoma, and what is the resulting effect on the tumor suppressor gene?  <response>: <reason> What gene mutation is responsible for familial melanoma, and what is the resulting effect on the tumor suppressor gene? Familial melanoma is commonly a result of mutations in CDKN2A on chromosome 9, which causes loss of p16 tumor suppressor gene. 