<prompt> Answer this question truthfullyHow does the cord factor of Mycobacteria tuberculosis contribute to the formation of granulomas, and what is the mechanism by which it achieves this contribution?  <response>: <reason> The cord factor of Mycobacteria tuberculosis contributes to the formation of granulomas by activating macrophages. This activation occurs through the induction of TNF-a, which is a cytokine that triggers the formation of granulomas. The cord factor achieves this contribution by binding to and activating Toll-like receptor 2 TLR2 on the surface of macrophages, leading to the production of TNF-a and other cytokines that drive the formation of granulomas. 