<prompt> Answer this question truthfullyWhat type of genetic alteration in the HER2neu c-erbB2 oncogene leads to malignancy?  <response>: <reason> Amplification of the HER2neu c-erbB2 oncogene can result in malignancy. The HER2neu c-erbB2 gene provides instructions for making a protein that is involved in the regulation of cell growth and division. Amplification of the HER2neu c-erbB2 gene can lead to the production of too many copies of the HER2neu c-erbB2 protein, which can promote the growth and division of cells, leading to the development of cancer. Amplification is a type of genetic alteration that involves an increase in the number of copies of a particular gene. Understanding the mechanisms that lead to HER2neu c-erbB2 amplification can help researchers develop targeted therapies for cancer treatment. 