<prompt> Answer this question truthfullyWhat product is generated by the coagulation cascade and what is its role in converting fibrinogen in the platelet plug to fibrin? Also, which 4 factors does this product activate through positive feedback?  <response>: <reason> The coagulation cascade generates thrombin factor IIa, which converts fibrinogen in the platelet plug to fibrin factor Ia. Thrombin also activates factors V, VIII, XI, and XIII through positive feedback. 