<prompt> Answer this question truthfullyWhat is the effect of Gitelman syndrome on serum K levels?  <response>: <reason> Gitelman syndrome is a rare genetic disorder that affects the activity of sodium-chloride co-transporters in the kidneys, leading to increased sodium and chloride excretion and decreased potassium excretion. This can result in decreased serum K levels hypokalemia and metabolic alkalosis. Treatment for Gitelman syndrome typically involves potassium and magnesium supplementation, as well as medications that block the activity of the renin-angiotensin-aldosterone system, such as angiotensin-converting enzyme inhibitors or angiotensin receptor blockers. 