<prompt> Answer this question truthfullyWhat is the potential complication that can arise in patients with Chronic Myeloid Leukemia, and what is the underlying mechanism that leads to this complication?  <response>: <reason> Patients with Chronic Myeloid Leukemia are at risk of developing a complication known as blast crisis, which is characterized by a rapid increase in the production of myeloblasts. This complication occurs when the malignant cells in the bone marrow undergo further genetic mutations that lead to a loss of differentiation and an increase in proliferation. Blast crisis is a serious complication that can be difficult to treat and is associated with a poor prognosis. Therefore, it is important for patients with CML to be closely monitored for signs of disease progression and to receive appropriate treatment as early as possible. 