<prompt> Answer this question truthfullyWhat is Pseudohypoparathyroidism type 1a, or Albright hereditary osteodystrophy, and how is it related to the Gs protein and PTH resistance?  <response>: <reason> Pseudohypoparathyroidism type 1a, also known as Albright hereditary osteodystrophy, is a rare genetic disorder that affects the bodys ability to regulate calcium and phosphorus levels. It is caused by a defective Gs protein in the kidney and bone, which is involved in the signaling pathway of parathyroid hormone PTH. This defect leads to end-organ resistance to PTH, which means that the body is unable to respond to the hormones signals to increase calcium and decrease phosphorus levels in the blood. As a result, patients with Pseudohypoparathyroidism type 1a may experience symptoms such as low blood calcium levels, muscle cramps, seizures, and bone abnormalities. Treatment for this condition typically involves calcium and vitamin D supplements, as well as other therapies to manage symptoms and prevent complications. 