<prompt> Answer this question truthfullyWhat is the mechanism by which Hodgkin lymphoma due to EBV infection may promote the survival of mutant B-cells?  <response>: <reason> Hodgkin lymphoma due to EBV infection may be associated with the activation of NF-κB, a transcription factor that plays a key role in regulating the immune response and cell survival. NF-κB activation can help mutant B-cells evade apoptosis, or programmed cell death, which is a natural process that eliminates damaged or abnormal cells from the body. In Hodgkin lymphoma, the abnormal Reed-Sternberg cells that are characteristic of the disease are thought to arise from mutant B-cells that have evaded apoptosis and undergone further genetic changes. The exact mechanisms by which EBV infection promotes the survival of these mutant B-cells are not fully understood, but it is thought that the virus may interfere with the normal regulation of NF-κB signaling, leading to its aberrant activation and the promotion of cell survival. Diagnosis of Hodgkin lymphoma usually involves a combination of imaging tests, such as CT scans or PET scans, and biopsy of the affected tissue. Treatment options may include chemotherapy, radiation therapy, andor stem cell transplantation, depending on the stage and severity of the disease. 