<prompt> Answer this question truthfullyWhat is Kartagener syndrome and what is the underlying genetic defect that causes it?  <response>: <reason> Kartagener syndrome is a rare genetic disorder that is inherited in an autosomal recessive manner. It is characterized by a triad of symptoms, including situs inversus reversal of the organs in the chest and abdomen, chronic sinusitis, and bronchiectasis a condition in which the airways in the lungs become damaged and widened. These symptoms are caused by immotile cilia, which are hair-like structures that line the respiratory tract and help to move mucus and other substances out of the lungs. In Kartagener syndrome, the immotile cilia are due to a defect in the dynein arms, which are responsible for the movement of the cilia. This defect can lead to recurrent respiratory infections, as well as fertility problems in some cases. 