<prompt> Answer this question truthfullyAmong cephalosporins, which generations have the broadest spectrum of activity?  <response>: <reason> The 4th cefepime and 5th ceftaroline generations of cephalosporins have the largest spectrum of activity. These generations of cephalosporins have the ability to target both gram-positive and gram-negative bacteria, including those that are resistant to other antibiotics. Cefepime, a 4th generation cephalosporin, is commonly used to treat infections in hospitalized patients, such as pneumonia, urinary tract infections, and sepsis. Ceftaroline, a 5th generation cephalosporin, is effective against methicillin-resistant Staphylococcus aureus MRSA and other resistant bacteria. The broad spectrum of activity of these cephalosporins makes them useful in treating serious infections caused by a wide range of bacteria. However, the use of broad-spectrum antibiotics should be carefully considered to avoid the development of antibiotic-resistant strains of bacteria. 