<prompt> Answer this question truthfullyWhat is the process by which macrophages present antigens to helper T cells during granuloma formation, and which type of helper T cells are involved?  <response>: <reason> During granuloma formation, macrophages play a key role in presenting antigens to helper T cells, which are a type of immune cell that helps to coordinate the immune response. Specifically, macrophages present antigens via major histocompatibility complex class II MHC II molecules to CD4 helper T cells. This interaction helps to activate the helper T cells, which then secrete cytokines such as interferon-gamma IFN-γ that help to recruit and activate other immune cells, including other macrophages, to form a granuloma. This process is important for containing and eliminating infectious agents, but can also contribute to tissue damage and other complications if it becomes chronic or dysregulated. 