<prompt> Answer this question truthfullyWhat is the specific tumor suppressor gene that is commonly associated with the development of Juvenile Polyposis Syndrome, Colon Adenocarcinoma, and Pancreatic Cancer when mutations occur?  <response>: <reason> Mutations in the SMAD4 gene also known as DPC4 are commonly associated with the development of Juvenile Polyposis Syndrome, Colon Adenocarcinoma, and Pancreatic Cancer. 