<prompt> Answer this question truthfullyHow is Severe Combined Immunodeficiency SCID secondary to a defective Interleukin-2 Receptor IL-2R inherited?  <response>: <reason> SCID secondary to a defective IL-2R is inherited in an X-linked pattern, which means that the mutated gene is located on the X chromosome. As a result, the disorder primarily affects males, who have only one X chromosome. Females can also be affected if they inherit two copies of the mutated gene. If a female is a carrier of the mutated gene, there is a 50 chance that her male offspring will inherit the disorder. 