<prompt> Answer this question truthfullyWhat are some other first-line antidepressants that can be used when major depression does not respond to an initial SSRI?  <response>: <reason> Other first-line antidepressants that can be used when major depression does not respond to an initial SSRI include different SSRI, SNRI, Bupropion, Mirtazapine, and Serotonin modulators e.g. vilazodone. 