<prompt> Answer this question truthfullyWhat is the relationship between CMV and mononucleosis?  <response>: <reason> CMV can cause mononucleosis, which is characterized by symptoms such as fever, sore throat, and fatigue. However, unlike the more common form of mononucleosis caused by the Epstein-Barr virus EBV, CMV-induced mononucleosis is heterophile negative. This means that the antibodies produced in response to CMV infection do not cross-react with the antibodies produced in response to EBV infection, which are typically used to diagnose mononucleosis. Instead, a diagnosis of CMV-induced mononucleosis may require additional laboratory testing, such as detection of CMV-specific antibodies or viral DNA. While CMV-induced mononucleosis is generally self-limited and resolves within a few weeks, it can cause more severe disease in immunocompromised individuals. 