<prompt> Answer this question truthfullyWhat is the effect of Liddle syndrome on serum Na levels?  <response>: <reason> Liddle syndrome is a genetic disorder that leads to increased reabsorption of sodium in the kidneys, resulting in increased serum Na levels hypernatremia. This is due to a gain-of-function mutation in the genes that encode for the epithelial sodium channel ENaC in the renal tubules. The increased activity of ENaC leads to excessive sodium reabsorption and potassium excretion, which can cause hypertension and hypokalemia. Treatment for Liddle syndrome typically involves the use of ENaC inhibitors, such as amiloride, to reduce sodium reabsorption and normalize serum electrolyte levels. 