<prompt> Answer this question truthfullyWhat are the McDonald Criteria and which disease are they used to diagnose?  <response>: <reason> The McDonald Criteria are diagnostic criteria used for multiple sclerosis. The criteria include the presence of disseminated lesions in space, which must involve at least two of the following locations: corpus callosum, juxtacortical, and infratentorial. Additionally, the criteria include disseminated lesions in time, which require a T2 bright lesion that enhances active and any other T2 bright lesion that does NOT enhance indicating that the lesions are separated by time. 