<prompt> Answer this question truthfullyWhat is peptic ulcer disease and which parts of the digestive system does it typically involve?  <response>: <reason> Peptic ulcer disease is a condition characterized by the formation of a solitary mucosal ulcer. This ulcer typically involves either the proximal duodenum 90 of cases or the distal stomach 10 of cases. Peptic ulcer disease is most commonly caused by infection with the bacteria Helicobacter pylori, but it can also be caused by long-term use of nonsteroidal anti-inflammatory drugs NSAIDs or other factors. Symptoms of peptic ulcer disease may include abdominal pain, nausea, vomiting, and weight loss. Treatment typically involves a combination of antibiotics to eradicate H. pylori infection, acid-suppressing medications, and lifestyle modifications. 