<prompt> Answer this question truthfullyWhat are the ways to distinguish drug-induced lupus erythematosus from other diseases?  <response>: <reason> As a reminder, rheumatologic conditions tend to declare themselves over time, as opposed to immediately displaying all the classic clinical manifestations of the disease.There is an inherited difficulty in distinguishing true drug-induced autoimmunity from an exacerbation of pre-existing autoimmunity or unmasking of a second autoimmune disease. It will become even more important to recognize medication-induced lupus syndromes given the expanding list of medications associated with DIL.Here are possible differentials to DIL:Idiopathic systemic lupus erythematosus Systemic sclerosis scleroderma Rheumatoid arthritis Connective tissue diseases Granulomatosis with polyangiitis Fibromyalgia Lichen planus Chronic radiation dermatitis Rosacea Psoriasis Dermatomyositis Granuloma annulare Actinic keratosis 