<prompt> Answer this question truthfullyCould you provide me with the original sentence?  <response>: <reason> Old criteria Required Chronic non-malignant lymphoproliferation Elevated peripheral blood Double Negative T cells DNTs Defective in vitro Fas mediated apoptosisNew criteria Required Chronic non-malignant lymphoproliferation 6 months lymphadenopathy andor splenomegaly Elevated peripheral blood DNTs Accessory Primary Accessory Defective in vitro Fas mediated apoptosis Somatic or germline mutation in ALPS causative gene FAS, FASL, CASP10 Secondary Accessory Elevated biomarkers Plasma sFASL 200pgml Plasma IL-10 20pgml Plasma or serum vitamin B12 1500ngL Plasma IL-18 500pgml Immunohistochemical findings on biopsy consistent with ALPS as determined by experienced hematopathologist Autoimmune cytopenias and polyclonal hypergammaglobulinemia Family history of ALPS or non-malignant lymphoproliferation Definitive diagnosis: Required plus one primary accessory criteria Probable diagnosis: Required plus one secondary accessory criteria Definitive and Probable ALPS should be TREATED THE SAME and patients counseled that they have ALPS if definitive or probable 