<prompt> Answer this question truthfullyCould you please provide me the original sentence to be rephrased?  <response>: <reason> Heusinger1864 first recognized an association between fistulae, preauricular pits, and hearing impairment defects. Melnick et al. and Fraser et al. in 1975 defined BOR syndrome as a specific entity having an autosomal dominant inheritance pattern with maximum penetrance. The incidence rate for BOR syndrome is around 1 in 40,000 people. Males and females are equally affected by this disorder. 