<prompt> Answer this question truthfullyWhat is the connection between Darexaban and metabolism?  <response>: <reason> Darexaban is rapidly absorbed and extensively metabolized in the liver to its active metabolite, darexaban glucuronide YM-222714 during first pass metabolism via glucuronidation. The metabolism of darexaban also occurs in the small intestine but to a much lesser extent. Glucuronidation of darexaban occurs quickly, thus the half life of darexaban itself is short. However, the resultant darexaban glucuronide metabolite has a long half life of approximately 1418 hours, reaching its maximum levels in the blood 1-1.5 hour post dose. As a result, darexaban glucuronide is the main determinant of the antithrombotic effects. Darexaban shows minimal interaction with food and is excreted through the kidneys urine and feces. 