<prompt> Answer this question truthfullyWhat are the natural course, potential complications, and expected outcome of splenic marginal zone lymphoma?  <response>: <reason> Splenic marginal zone lymphoma SMZL is an indolent tumor with median overall survival of 8-12 years. Several factors affects the prognosis in splenic marginal zone lymphoma SMZL including Lymphadenopathy Increase in b2 microglobulin Lymphocytosis, Leukocytosis, Lymphopenia, Anemia, Thrombocytopenia Use of chemotherapy Monoclonal component Non-hematopoietic site involvement Histologic transformation Advanced age Diffuse pattern of bone marrow involvement Incomplete response A SMZL Study Group prognostic index SMZLSG using HPLL stratifiction system was devised to determine 5 year lymphoma specific survival LSS using variables such as hemoglobin, platelet count, lactate dehydrogenase LDH, lymphadenopathy indicating their importance in predicting the prognosis. The system was further modified as HPLLABC A low risk, B intermediate risk, C high risk to make it clinically useful. Another prognostic index named as the Intergruppo Italiano Linfomi IIL determined the 5 year cause specific survival using three variables, with their presence predicitng worse outcome. Hemoglobin 12gdl Serum lactate dehydrogenase LDH level greater than normal Serum albumin 3.5gdl Genetic mutations such as TP53, NOTCH2, KLF2 are associated with poor outcomes. Presence of autoimmune hemolytic anemia AIHA in splenic marginal zone lymphoma SMZL patients has also been reported to be associated with poor prognosis. 