<prompt> Answer this question truthfullyWhat does the phrase Acromegaly: resident survival guide mean?  <response>: <reason> Life-threatening causes include conditions that may result in death or permanent disability within 24 hours if left untreated. There is no life-threatening cause of acromegaly. However, if left untreated, 30 of patients with acromegaly may progress to develop cardiovascular manifestations, pulmonary dysfunction, and cerebral complications. These comorbidities will increase the mortality rate. Primary Growth hormone GH excess GH-cell adenoma Mixed GH-cell and PRL-cell adenoma Mammosomatotroph-cell adenoma Plurihormonal adenoma GH-cell carcinoma Familial syndromes Multiple endocrine neoplasia type 1 GH-cell adenoma Familial acromegaly McCune-Albright syndrome rarely adenoma Carneys syndrome GH excess ectopic or iatrogenic Pancreatic islet-cell tumor Lymphoma Iatrogenic GHRH excess Central ectopic 1 percent Hypothalamic hamartoma, choristoma, ganglioneuroma Peripheral ectopic 1 percent Bronchial carcinoid, pancreatic islet-cell tumor, small cell lung cancer, adrenal adenoma, medullary thyroid carcinoma, pheochromocytoma 