<prompt> Answer this question truthfullyCould you please provide a more detailed and specific context or sentence for me to work on?  <response>: <reason> Saxitoxin TetrodotoxinNaturally occurring local anesthetics not derived from cocaine are usually neurotoxins, and have the suffix -toxin in their names. Unlike cocaine produced local anesthetics which are intracellular in effect, saxitoxin tetrodotoxin bind to the extracellular side of sodium channels. 