<prompt> Answer this question truthfullyWhat is hypolipoproteinemia, and what are the factors that cause it?  <response>: <reason> The following are the list of conditions which can cause low LDL C and low HDL C levels:Primary lipoprotein abnormalitiesHypoalphalipoproteinemia Apolipoprotein A-1 deficiency. Low HDL Hypobetalipoproteinemia and Abetalipoproteinemia. Low LDL and VLDL, but not low HDL Chylomicron retention disease Cholesteryl ester transfer protein CETP elevation Familial combined hypolipidemia does not increase risk of atherosclerosis LCAT deficiency Proprotein convertase subtilisinkexin type 9 PCSK9 loss of function or deficiency Adenosine triphosphate ATP-binding cassette transporter ABCA1 gene mutations Familial HDL deficiency. This is the most common cause of low HDL and coronary artery disease. Tangier diseaseSecondary causesAnemia Chronic inflammation Chronic liver disease Critical illness Hyperthyroidism Infection Malabsorption Malignancy 