<prompt> Answer this question truthfullyWhat are the possible causes or conditions that can result in chronic neutrophilic leukemia?  <response>: <reason> ABBREVIATIONSNA: Not available, NL: Normal, FISH: Fluorescence in situ hybridization, PCR: Polymerase chain reaction, LDH: Lactate dehydrogenase, PUD: Peptic ulcer disease, EPO: Erythropoietin, LFTs: Liver function tests, RFTs: Renal function tests, LAP: Leukocyte alkaline phosphatase, LAD: Leukocyte alkaline dehydrgenase, WBCs: White blood cells.Myeloproliferative neoplasms MPN Clinical manifestations Diagnosis Other features Symptoms Physical examination CBC Peripheral smear Bone marrow biopsy Other investigations WBCs Hb Plat- elets Leuko-cytes Blasts Left shift Baso- phils Eosino- phils Mono- cytes Others Chronic neutrophilic leukemia CNL Asymptomatic Constitutional symptoms Bleeding Infection Splenomegaly Heptomegaly Purpura Anemia related Minimal NL NL NL LDH B12 levels Uniforme and intense hypercellularity with minimal to none fibrosis Neutrophil toxic granulations and Dohle bodies FISH Imaging for hepatosplenomegaly Associationed with polycythemia vera and plasma cell disorders Leukocytosis with chronic neutrophilia Chronic myeloid leukemia CML, BCR-ABL1 Asymptomatic Constitutional Hyperviscosity andor anemia related Bleeding Infection Splenomegaly 4676 Purpura Anemia related Priapism 2 NA NL Hypercellurarity with granuloscytosis and erythrocytosis Fibrosis FISH for t9;22q34;q11.2 Reverse transcriptase quantitative PCR RQ-PCR for BCR-ABL Granulocytic dysplasia is minimalabsent May present with blast crisis Absolute leukocytosis median of 100,000μL Classic myelocyte bulge thrombocytopenia indicates advanced stage Polycythemia vera PV Constitutional Thromboembolism and bleeding Pruritus after a warm bath PUD related Facial ruddiness Related to underlying cause Splenomegaly Renal bruit NL or None - or NL or NL Serum ferritin Folate levels B12 levels NL Hypercellularity for age with tri-lineage growth Myelofibrosis in up to 20 of patients Radioisotope studies Serum EPO levels LFTs RFTs Imaging studies May transform into myelofibrosis or leukemia Primary myelofibrosis PMF Constitutional Anemia related Bleeding Infection Abdominal Pain Hepatosplenomegaly Petechiae ecchymoses Abdominal distension Lymphadenopathy Erythroblasts - Absent NL NL LAP LAD Uric acid B12 levels Variable with fibrosis or hypercellularity JAK2 mutation CALR mutation MPL mutation Bone marrow aspiration shows a dry tap Variable with leukocytosis or leukopenia Essential thrombocythemia ET Headache Dizziness Visual disturbances Priapism Acute chest pain Splenomegaly Skin bruises NL or None - or absent NL NL NA NormalHypercellular JAK2 mutation CALR mutation MPL mutation Thrombosis Hemorrhage Pregnancy loss Chronic eosinophilic leukemia, not otherwise specified NOS Constitutional Rash Rhinitis Gastritis Thromboembolism related Hypertension Eczema, mucosal ulcers, erythema Angioedema Ataxia Anemia Lymphadenopathy Hepatosplenomegaly Present B12 levels LDH Hypercelluar with eosinophilic precursors, eosinophils, and atypical mononuclear cells FISH Cytogenetic analysis of purified eosinophils and X-chromosome inactivation analysis Heart failure Lung fibrosis Encephalopathy Erythema annulare centrifugam MPN, unclassifiable Similar to other myeloproliferative neoplasms Similar to other myeloproliferative neoplasms Variable or or or May resemble other myeloproliferative neoplasms megakaryocyte proliferation with variable hypercellularity in granulocytic or erythrocytic cell lines NA Similar to other myeloprolifeartive neoplasms but do not fulfil the criteria to be classified to a specific type Mastocytosis Constitutional Pruritus Flushing Urticaria Blisters Hypotension PUD Bleeding Bronchoconstriction Mastocytosis exanthema Blistering Swelling Lymphadenopathy Bleeding Fibrosis None - NL NL Alkaline phosphatase LDH or Multifocal dense infiltrates of mast cells with atypical morphology in 25 Cytogenetic analysis for c-KIT receptor mutations Serum tryptase levels 24-hour urine test for N-methyl histamine and 11-beta- prostaglandine Skin most commonly involved Susceptibility to anaphylaxix Osteoporosis Myeloid lymphoid neoplasms with eosinophilia and rearrangement of PDGFRA, PDGFRB, or FGFR1, or with PCM1 - JAK2 Asymptomatic Constitutional Rash Cough breathlessness Peripheral neuropathy encephalopathy Fever Lymphadenopathy NL - NL None NL Myeloid expansion with eosinophilia FISH shows t8;13 and t8;22 May present or evolve into acute myeloid or lymphoblastic leukemia Leukocytosis 30 - 59 × 10 9 L B-lymphoblastic leukemialymphoma Constitutional Anemia related Bleeding Infection Bone pain Pallor Petechiae Organomegaly Lymphadenopathy NL or 25 NA or or or Auer bodies Hypercellular with blast infilteration with or without myelodysplasia Cytogenetic analysis Flow cytometry FISH May present as extramedullary disease Myeloid sarcoma Myelodysplastic syndromes MDS Constitutional Anemia related Bleeding Infection Pallor Petechiae Organomegaly Variable - Macro-ovalocytes Basophilic stippling Howell-Jolly body Hypercellular normocellular bone marrow with dysplastic changes Cytogenetic analysis Flow cytometry Leukemia transformation Acquired pseudo-Pelger-Huët anomaly Acute myeloid leukemia AML and related neoplasms Constitutional Anemia related Bleeding Bone pain Joint pain Infections Infection related Pallor Leukemia cutis Bruising petechiae Lymphadenopathy Hepatosplenomegaly NL or NA or or or Potassium Uric acid Phosphorus Calcium LDH Increased immature myeloid cells with dysplasia Cytogenetic analysis Flow cytometry FISH Common in Down syndrome Blastic plasmacytoid dendritic cell neoplasm Cutaneous symptoms brownpurple nodular lesions on face, scalp, lower limb trunk Brownviolaceous bruise like lesions Lymphadenopathy Splenomegaly NL NL NL NL Neutropenia Malignant cells Immunohistochemistry or flow cytometry for CD4 CD56 TdT expression positive May develop chronic myelomonocytic leukemia CMML Myelodysplastic myeloproliferative neoplasms MDSMPN Chronic myelomonocytic leukemia CMML Constitutional Anemia related Bleeding Infections Bone pain Leukemia Cutis Organomegaly Bruising 20 NL LDH Myelodysplastic and myeloproliferative feature Cytogenetic analysis Flow cytometry Overlapping of both, MDS and MPN Absolute monocytosis 1 × 10 9 L defining feature MD-CMML: WBC 13 × 10 9 L FAB MP-CMML: WBC 13 × 10 9 L FAB Atypical chronic myeloid leukemia aCML, BCR-ABL 1- Asymptomatic Constitutional Hyperviscosity andor anemia related Bleeding Infection Splenomegaly 4676 Purpura Anemia related Priapism 20 2 of WBCs NA NA NA Granulocytic hyperplasia with prominent dysplasia Cytogenetic analysis Flow cytometry Granulocytic dysplasia is prominent Absence of BCR-ABL or PDGFRA, PDGFRB, or FGFR1 rearrangements WBC 13 × 10 9 L Juvenile myelomonocytic leukemia JMML Infections Anemia related Hepatosplenomegaly Lymphadenopathy Rash NA NA NA Serum Iron B12 levels Hypercelluar with myeloid cells in stages of maturation Cytogenetic analysis Flow cytometry Polyclonal hypergammaglobulinemia MDS MPN with ring sideroblasts and thrombocytosis MDSMPN-RS-T Constitutional Anemia related Thrombosis Variable NL or NL - NL NA NA Serum Iron Hypercellularity with dyserythropoiesis and increased megakaryocytes Cytogenetic analysis Flow cytometry Large atypical megakaryocytes Ringed sideroblasts SF3B1 mutation T-lymphoblastic leukemia lymphoma T-lymphoblastic leukemia lymphoma Constitutional Anemia Related Bleeding Superior vena cava syndrome Lymphadenopathy Mediastinal mass Pleural effusions Tracheal obstruction Pericardial effusions 25 blasts Leukemia 25 blasts Lymphoma or or or LDH Positive for TdT Hypercelluarity with increased T cells precursors Cytogenetic analysis Flow cytometry FISH May involve brain, skin, and testes. Provisional entity: Natural killer NK cell lymphoblastic leukemialymph Constitutional Anemia Related Bleeding Superior vena cava syndrome Lymphadenopathy Mediastinal mass Pleural effusions Tracheal obstruction Pericardial effusions or or or LDH NA Cytogenetic analysis FISH Flow cytometry Similar to T-cell lymphoblastic leukemia but may have more aggressive clinical course. Diagnosis is usually based on presence of CD56 expression, and T-cell -associated markers such as CD2 and CD7. B-cell markers are absent. Provisional entity: Early T-cell precursor lymphoblastic leukemia Constitutional Anemia Related Bleeding Superior vena cava syndrome Lymphadenopathy Mediastinal mass Pleural effusions Tracheal obstruction Pericardial effusions or or or LDH Hypercelluarity with increased T cells precursors Cytogenetic analysis FISH Flow cytometry Similar to T-cell lymphoblastic leukemia but is more aggressive clinically and cell are characterized by cytometry as CD1a , CD8 , CD5 dim, and positivity for 1 or more stem cell or myeloid antigens. Gene expression indicates more immature cells as compared to other subtypes of T-cell neoplasms. 