<prompt> Answer this question truthfullyWhat are the factors that lead to septic arthritis?  <response>: <reason> Gram-negative bacilli account for 10 to 20 of septic arthritis causes. 10 of patients with nongonococcal septic arthritis are due to polymicrobial cause of infections. Anaerobes are also can cause septic arthritis in few cases. Most common cause of septic arthritis in children age 2 years are Haemophilus influenzae in immunized children, Staph. aureus, group A Streptococcal infections and Kingella kingae. The source of infection in most of the cases 50 often from the skin, lungs or bladder.Common microorganisms causing septic arthritis includes: Staphylococcus aureus Streptococcal pyogenous Streptococcal agalectae Streptococcal pneumonia Neisseria gonorrhoeae Escherichia coli Staphylococcus epidermidis Haemophilus influenzae Pseudomonas aeruginosa SalmonellaPeptostreptococcus Bacteroides fragilis Fusobacterium species Borrelia burgdorferi Brucella Mycobacterium tuberculosis Mycoplasma hominis Fungal infection such as Blastomycosis Cryptococcus Coccidioidomycosis Sporotrichosis CandidaMicroorganism or other infectious disease Associated risk factors Key clinical clues Staphylococcus aureus Rheumatoid arthritis Diabetes mellitus HIV patients Healthy adult with skin lesions and previously history of damaged joint e.g, rheumatoid arthritis or prosthetic joint Streptococcus pyogenes Streptococcal pneumonia Autoimmune diseases Chronic skin infections Trauma Healthy adults with spleenic dysfunction Groups B Streptococcal infection Immunocompromised patients Diabetes mellitus Malignancy Severe genitourinary or gastrointestinal infections Healthy adults with spleenic dysfunction Neisseria gonorrhoeae Complement deficiency Systemic lupus erythematosus Male homosexuality low socioeconomic status Healthy young and sexually active adult with Tenosynovitis Skin lesions such as vesicular pustules Complement deficiency C5-9 deficiency Culture negativity on synovial fluid analysis Gram-negative bacilli Pseudomonas Escherichia coli History of intravenous drug abuse Extremes of age Immunocompromised patients Immunocompromised patients Recent history gastrointestinal infections such as infectious diarrhea caused by Shigella, Salmonella, Campylobacter, or Yersinia Haemophilus influenzae Unimmunized children Anaerobes Diabetes mellitus Patients with prosthetic joints Immunocompromised hosts Recent history of gastrointestinal infection Mycobacterium spp. Recent history of travel to endemic areas Immunocompromised patients Recent history of travel to endemic areas e.g. India, South Africa, Mexico etc. Incidious onset of monoarthritis Fungal infection such as Blastomycosis Cryptococcus Coccidioidomycosis Sporotrichosis Immunocompromised patients Immunocompromised patients Incidious onset of monoarthritis Mycoplasma hominis Recent history of urinary tract procedure Immunocompromised patients Recent history of urinary tract procedure Viral arthritis Immunocompromised patient Polyarthritis Fever Rash HIV infection History of multiple sexual partners History of IVDA Sterile, acute synovitis or reactive arthritis Lyme disease History of recent visit to endemic Lyme area History of erythema migrans History of recent visit to endemic Lyme area Reactive arthritis Recent gastrointestinal genitourinary infection Recent gastrointestinal genitourinary infection Enthesopathy Skin lesions Uveitis Conjunctivitis Endocarditis History of endocarditis Damaged heart valves Congenital heart diseases Fever New onset of heart murmur Septic and sterile synovitis Septic joint more common in IVDA 