<prompt> Answer this question truthfullyWhat is the underlying biological mechanism of hemothorax?  <response>: <reason> The pathogenesis of hemothorax include Three mechanisms of bleeding in haemothorax:Torn adhesion between the parietal and visceral pleurae. Rupture of neovascularized bullae as a complication of subpleural emphysematous blebs. Torn congenital aberrant vessels branching from the cupola and distributed in and around the bulla in the apex of the lung.Ehlers-Danlos syndrome EDS forms part of a spectrum of genetically based connective tissue disorders that includes osteogenesis imperfecta. Vascular Ehlers-Danlos syndrome EDS IV is characterized by an alteration in the COL3A1 gene. This gene encodes type III collagen and The alteration of this type of collagen produces aneurysms and ruptures of vessels and organs that can lead to haemothorax.OslerWeberRendu disease, also known as hereditary hemorrhagic telangiectasia HHT, is an autosomal dominant disease characterized by multiple cutaneous, systemic, andor pulmonary arteriovenous malformations AVMs. Bleeding from pulmonary lesions usually occur as hemoptysis and rarely as spontaneous haemothorax. There is an association between Osler-Weber-Rendu disease and bilateral heterochronic spontaneous hemothorax.Coastal exostosis or Osteochondroma is an autosomal dominant hereditary abnormality and the most common benign thoracic bone tumor. It often presents singly or in multiple sites that can cause laceration of the lung and hemothorax.Hemophilia A is a X-linked hereditary disorder of blood clotting that caused by the development of an inhibitor against coagulation factor VIII FVIII. Hemophilia A manifests with early muscle and subcutaneous bleeding and rarely with haemothorax.Glanzmann thromboastenia is an autosomal-recessive bleeding disorder characterized by a lifelong bleeding tendency due to abnormalities of the platelet integrin αΠbβ3 glycoprotein GP IIb; CD41IIIa; CD61. Glanzmann thromboastenia usually presents with mucocutaneous bleeding such as easy bruising, purpura, gingival bleeding, epistaxis, menorrhagia, haemarthrosis, haematuria, intracranial and visceral hemorrhage are rare but even rarer is Spontaneous Haemothorax.Type I neurofibromatosis NF-1 or Von Recklinghausens disease VRD is an autosomal dominant disease. This entity can affect any organ system and is characterized by skin tumors and abnormal cutaneous pigmentation. Pathogenetic mechanisms for vasculopathy associated with VRD are: I direct vascular invasion from adjacent tumors; and II vascular dysplasia with thickening and concomitant reduced the strength of the vessel wall and an aneurysm formation. There are other hereditary entities such as LoeysDietz syndrome, familial thoracic aortic aneurysm syndrome, or ShprintzenGoldberg syndrome that are predisposed to aortic dissection and haemothorax. 