<prompt> Answer this question truthfullyWhat are the epidemiology and demographics associated with toxic megacolon?  <response>: <reason> The precise incidence of toxic megacolon is unknown in general population. The incidence of toxic megacolon in the associated disorders including ulcerative colitis, Crohns disease and Clostridium difficile is: 1000-2500 in 100,000 cases of the ulcerative colitis. 4400-6300 in 100,000 cases of the Crohns disease. 400-3000 in 100,000 cases of the Clostridium difficile.The mortality rate of toxic megacolon associated with clostridium difficile is approximately 38-80. Patients of all age groups may develop toxic megacolon. There is no racial predilection described in toxic megacolon. Toxic megacolon affects men and women equally. 