<prompt> Answer this question truthfullyWhat are the factors that increase the risk of developing Polycythemia vera?  <response>: <reason> Risk factors in the development of polycythemia vera are: Old age 65 years older mutations can accumulate in hematopoietic stem cells over time, resulting in a higher probability of a JAK2 mutation. Family history of polycythemia vera First-degree relatives of patients with polycythemia vera have a 5 to 7-fold higher risk for development of a myeloproliferative neoplasm. The cumulative risk of developing myelofibrosis is 6 at 10 years, 14 at 15 years, and 26 at 20 years from the initial diagnosis of polycythemia vera. Ashkenazi Jewish descent 