<prompt> Answer this question truthfullyWhat role does the heart play in mixed connective tissue disorder?  <response>: <reason> A. Kasukawa criteriaMCTD will be diagnosed when all 3 conditions are fulfilled. B. Sharp criteria Definite diagnosis requires 4 major criteria with positive anti-U1 RNP greater than 1:4000 and a negative anti-Sm Ab. U1 RNP is the specific RNP protein associated with this syndrome.Probable diagnosis requires either 3 major criteria or 2 major criteria which must come from the first 3 major criteria listed and 2 minor criteria plus an anti-U1 RNP greater than 1:1000.Possible diagnosis requires 3 major criteria without serologic evidence of disease or, if anti-U1 RNP is greater than 1:100, 2 major criteria or 1 major and 3 minor criteria.Major criteria are severe myositis, pulmonary involvement diffusing capacity of lung for carbon monoxide 70 of normal, pulmonary hypertension, proliferating vascular lesions on lung biopsy, Raynaud phenomenon or esophageal hypomotility, swollen hands or sclerodactyly, and highest observed anti-U1 RNP 1:10.000 with negative anti-Sm Ab.Minor criteria are alopecia, leukopenia 4000 WBCmL, anemia 10 gdL for females, 12 gdL for males, pleuritis, pericarditis, arthritis, trigeminal neuralgia, malar rash, thrombocytopenia 100.000mL, mild myositis, and history of swollen hands.C. Alarcon-Segovia and Villareal classification and diagnostic criteria Serologic criterion is a positive anti-RNP at a titer of 1:1600 or higher. Clinical criteria at least 3 are edema of the hands, Raynaud phenomenon i.e., 2 or 3 color changes, acrosclerosis, synovitis, and myositis laboratory or biopsy evidence. 