<prompt> Answer this question truthfullyWhat is the history and progression of breast cancer in its natural state?  <response>: <reason> There is a theory that up to 22 of small radiographically detected breast tumors regress, based on an analysis in a large population. The study is supported by NCIs SEER data. The natural history of breast cancer is extremely variable ranging from indolent cancers to aggressive cancer s that can metastas ize with fatal consequences. 