<prompt> Answer this question truthfullyWhat is the pathophysiology of ARVD12?  <response>: <reason> The pathogenesis of ARVD involves apoptosis with fatty and fibro-fatty infiltration of the right ventricular free wall leading to heart failure and ventricular arrhythmias.This variant 611528 is associated with a mutation in the JUP gene 173325 on chromosome 17q21. 