<prompt> Answer this question truthfullyWhat is the underlying mechanism of Creutzfeldt-Jakob disease?  <response>: <reason> On gross histopathological analysis, the brain tissue appears spongy with areas of perforation within the brain tissue.CJD is associated with the build-up of abnormal prion proteins.The following microscopic findings may be present in CJD: Presence of florid plaques, defined as round, packed deposits of abnormal prion protein in variant CJD Spongiform changes Neuronal loss Astrocyte proliferation Deposition of prion protein throughout the brain 