<prompt> Answer this question truthfullyWhat are the natural progression, potential issues, and predicted outcome of cutaneous follicle center lymphoma?  <response>: <reason> Transformation of systemic follicular lymphoma FL into aggressive non-Hodgkins lymphoma is associated with poor prognosis and has been reported with a wide range of frequency range between 1070. While the annual risk of transformation of systemic follicular lymphoma FL is 3. 