<prompt> Answer this question truthfullyWhat is Ameloblastoma, and what are the factors that lead to its occurrence?  <response>: <reason> There are no established causes for ameloblastoma. It is thought that ameloblastoma may be the result of either decreased expression of matrix metalloproteinase-2 which helps in inhibition of the local invasiveness of ameloblastoma, or it is may be due to increased expression of α5β1 integrin which participate in the local invasiveness of ameloblastoma. 