<prompt> Answer this question truthfullyWhat are the consequences of a deficiency in 21-hydroxylase?  <response>: <reason> Life-threatening causes include conditions which may result in death or permanent disability within 24 hours if left untreated. There are no life-threatening causes of 21-hydroxylase deficiency.Mutations in CYP21A1 and CYP21A2 gene on chromosome 6.Approximately 70 of disease associated with CYP21A2 is due to gene conversion and microdeletions in CYP21A1 gene. Approximately 25 to 30 are chimeric genes due to large deletions.Approximately 1 to 2 of cases are due to de novo mutations because of high variability of the CYP21A2 locus. Chromosome 6 uniparental disomy is a rare cause of 21-hydroxylase deficiency with an unknown prevalence. Mutation in CYPA21 gene 