<prompt> Answer this question truthfullyWhat are the natural history, complications, and prognosis associated with splenic marginal zone lymphoma?  <response>: <reason> Large B-cell lymphoma Autoimmune complications such as: Autoimmune hemolytic anemia Immune thrombocytopenic purpura ITP Lupus anticoagulant C1-esterase inhibitor deficiency Acquired von Willebrand disease 