<prompt> Answer this question truthfullyCan PCI be performed on lesions that are angulated or tortuous?  <response>: <reason> Severe vessel tortuosity and the presence of eccentric angulated lesions have long been identified as significant predictors of percutaneous coronary intervention PCI failure, as well as worse clinical outcomes . Challenges in the treatment of angulated lesions and lesions in tortuous segments includes difficulty in delivering the interventional equipment and the increased risk of vessel dissection and vessel perforation. 