<prompt> Answer this question truthfullyWhat are the phagocyte congenital defects?  <response>: <reason> Autosomal recessive AR transmission. It is caused by homozygous or compound heterozygous mutation in the cathepsin C gene CTSC on chromosome 11. Patients present with palmoplantar keratoderma, periodontitis, and premature loss of dentition. Acitretin if started at a early age can help patients have normal adult dentition. 