<prompt> Answer this question truthfullyWhat does the physical examination for pseudoxanthoma elasticum involve?  <response>: <reason> In order to make a diagnosis, the patient must have two major criteria from two separate categories or one major criterion plus one or more minor criteria.Major criteriaSkin - Yellow papulesplaques on the lateral neck or body, skin biopsy showing increased calcification with clumping of elastic fiber from affected skin Eye - Peau dorange changes, angioid streaks confirmed by angiography Genetics - Presence of a pathogenic mutation of both alleles of ABCC6, a first-degree relative who meets criteria for definitive pseudoxanthoma elasticumMinor criteriaEye - One angioid streak shorter than one disk diameter, comets in the retina, one or more wing signs on the retina Genetics - A pathogenic mutation in one allele of the ABCC6 gene 