<prompt> Answer this question truthfullyWhat is the physiological process underlying the sensation of itch?  <response>: <reason> The following table shows some of the mediators, receptors and drugs related to itching :Mediators Receptors Drugs Histamines Histamine receptors H1R, H2R, and H4R Antihistamines Opioid peptides μ-receptor, κ-receptor Naloxone, Naltrexone, Nalfurafine Platelet-activating factor PAF PAF receptor Rupatadine, Apafant Bradykinin Bradykinin receptors B1R and B2R Icatibant, Bromelain Leukotrienes LTs Leukotriene receptors Zafirlukast, Pranlukast, Montelukast Substance-P NK receptor NKR1 Aprepitant, Fosaprepitant, Casopitant, Vestipitant, Orvepitant, Lanepitant, Dapitant, L-733, 060 5-Hydroxy tryptamine 5-HT 5-HT receptors 5-HT2 and 5HT3 Paroxetine, Fluoxetine, Mirtazapine, Ondansetron IL-2, IL-3, IL-4, IL-6, and IL-10 IL-2 and IL-6 receptors Cyclosporine, Dupilumab, Lebrikizumab Cannabinoids Cannabinoid receptors CB1 and CB2 receptors Palmitoylethanolamine PEA Calcitonin gene related peptide CGRP CGRP receptors CALCRL and RAMP1 Erenumab, Fremanezumab, Galcanezumab Proteases Proteases-activated receptors PARs, PAR14 Leupeptin, E6005, E-64, Chymostatin 