<prompt> Answer this question truthfullyWhat are the natural history, complications, and prognosis associated with antiphospholipid syndrome?  <response>: <reason> The prognosis of antiphospholipid syndrome is as follows: It is associated with increased mortality and morbidity. The mean age of death is 59 years. Main causes of death in the order of percentage include the following: Thrombosis 31 Sepsis 27 Malignancy 14 Hemorrhage 11 Systemic lupus erythematosus involvement 8 Catastrophic APS 