<prompt> Answer this question truthfullyWhat are the historical background and symptoms of Amyotrophic lateral sclerosis?  <response>: <reason> ALS is a neurodegenerative disease that ultimately leads to paralysis. Patients may have a positive history of:Weakness start proximally distally in upper or lower limbs. Twitching Cramping Gradually Stiffness also develop in affected muscles Difficulty swallowing speech. DroolingCommon symptoms of ALS include:Muscle weakness Muscle stiffness Gait disturbances Dysarthria dysphagia with bulbar-onset ALS. Respiratory difficulties 