<prompt> Answer this question truthfullyWhat is the meaning of transplant lymphoproliferative disorder?  <response>: <reason> It is understood that post transplant lymphoproliferative disorder is the result of B cell proliferation induced by Epstein-Barr virus EBV infection. 90 to 95 percent of patients with post transplant lymphoproliferative disorder shows positive serologic of infection especially with Epstein-Barr virus EBV infection. Membrane proteins associated with EBV plays a major role in contribute to B cell growth and survival. LMP-1-Latent membrane protein 1 LMP-2A-Latent membrane protein 2 EBNA-2 Epstein-Barr nuclear antigen 2 and EBNA-LP Epstein-Barr nuclear antigen 2 ladder proteinPost transplant lymphoproliferative disorder arises from germinal center or post-germinal center B cell s B-PTLD, which are normally involved the production of antibodies and durable memory B cells. The pathogenesis of post transplant lymphoproliferative disorder is also characterized by the production of interleukin-10.The overexpression of bcl-2 has been associated with the development of post transplant lymphoproliferative disorder. On gross pathology, characteristic findings of post transplant lymphoproliferative disorder, include: Resemblance to large cell lymphomas Palpable lymphadenopathy based on the level of involvementOn microscopic histopathological analysis, characteristic findings of post transplant lymphoproliferative disorder, include: Resemblance to large cell lymphomas Large lymphoid cells with a diameter 2x a resting lymphocyte 