<prompt> Answer this question truthfullyUnder the category of acute leukemia, what is meant by megakaryoblastic leukemia?  <response>: <reason> Clonal proliferation of early megakaryoblasts in the bone marrow results in acute megakaryoblastic leukemia AMKL. It has a bimodal onset of presentationoccurs both in the pediatric age group 4 years and adults. In childhood, it is more prevalent in patients with Down syndrome. While it is rare in adults, approximately 0.6 243603 reported in the GIMEMA trial. Cases of AMKL secondary to chronic myelogenous leukemia and essential thrombocytosis have been reported in the medical literature. 