<prompt> Answer this question truthfullyWhat is the pathophysiological mechanism behind Churg-Strauss syndrome?  <response>: <reason> HLA -DRB17, and HLA-DRB4 are associated with the development of eosinophilic granulomatosis with polyangiitis. HLA-DRB4 is correlated with increasing risk of development of vascular manifestations of the churg-strauss syndrome. Single- nucleotide polymorphisms in the Interleukin-10 gene IL10.2 haplotype have been associated in the pathogenesis of eosinophilic granulomatosis with polyangiitis. 