<prompt> Answer this question truthfullyWhat is the underlying disease process of neuroblastoma?  <response>: <reason> On microscopic histopathological analysis the presence of round blue cells separated by thin fibrous septa are characteristic findings of neuroblastoma. Other findings of neuroblastoma on light microscopy may include: Homer-Wright rosettes rosettes with a small meshwork of fibers at the center Neuropil -like stroma paucicellular stroma with a cotton candy-like appearanceOn electron microscopy neuroblastoma is characterized by:Dendritic processes with longitudinally oriented microtubules Membrane bound electron-dense granules that contain catecholamines Presence of desmosomes Absence of glycogenOn immunohistochemistry neuroblastoma is characterized by:Protein gene product PGP 9.5 ve Monoclonal antibody NB84 ve Synaptophysin ve CD99 marker -veBased on the degree of the cellular maturity and composition, neuroblastoma may be classified into three subtypes according to the International Neuroblastoma Pathology Classification which include: Subtypes Description Undifferentiated Neuroblastoma Completely formed by neuroblasts with no maturity of ganglion cells Poorly Differentiated Neuroblastoma Mostly formed by neuroblasts with less the 5 maturing ganglion cells Differentiating Neuroblastoma Predominantly formed by neuroblasts but with more than 5 mature ganglion cells 