<prompt> Answer this question truthfullyWhat is the explanation for the abnormal functioning of cells in Langerhans cell histiocytosis?  <response>: <reason> Development of Langerhans cell histiocytosis is the result of multiple genetic mutations. Genes commonly involved in the pathogenesis of Langerhans cell histiocytosis include:BRAF BRAF V600E gene mutation located on Chromosome 7 MAP2K1 gene mutation located on Chromosome 15Less common genetic mutations involved in the pathogenesis of Langerhans cell histiocytosis include: ARAF gene mutation located on the X-chromosome ERBB3 gene mutation located on chromosome 12The aforementioned genetic mutations, which occur among patients of Langerhans cell histiocytosis, will lead to constitutive activation of downstream extracellular signal-related kinase ERK and mitogen-activated protein kinase MEK. Induction of ERK activation is a universal feature that is found in most of the cases of Langerhans cell histiocytosis. The MAPK ERK pathway also known as the Ras -RAF-MEK- ERK pathway is a cascade of proteins that transmit cellular signal from receptors found on the surface of the cell to the nucleus, this ultimately results in the activation of cellular DNA production. 