<prompt> Answer this question truthfullyWhat does the term minimal change disease mean?  <response>: <reason> Minimal change disease MCD is considered a disease of childhood. It is responsible for up to 70-90 of nephrotic syndrome in patients less than 10 years of age, and up to 50 of older children. Among children, several studies have shown a male predominance with approximately 2:1 male to female ratio. 