<prompt> Answer this question truthfullyCould you provide me with the context and intended audience for this question?  <response>: <reason> The pathogenesis of ARVD involves apoptosis with fatty and fibro-fatty infiltration of the right ventricular free wall leading to heart failure and ventricular arrhythmias.This variant 604400 is associated with a mutation in the TMEM43 gene 612048 on chromosome 3p23 region. 