<prompt> Answer this question truthfullyWhat is the management of Picks disease?  <response>: <reason> A number of case series have now been published looking at the pathological basis of frontotemporal dementia. As with other syndromes associated with FTLD, a number of different pathologies are associated with FTD:Picks disease 3-repeat Tau inclusions Other tau-positive pathology including FTDP-17, corticobasal degeneration, progressive supranuclear palsy FTLD with ubiquitin positive, tau- and alpha-synuclein negative inclusions with and without motor neuron degeneration recently characterized by nuclear and cytoplasmic staining of TDP-43 protein Dementia lacking distinctive histology In rare cases, patients with clinical FTD were found to have changes consistent with Alzheimers disease on autopsy Evidence suggests that FTD selectively impairs spindle neurons, a type of neuron which has only been found in the brains of humans, great apes, and whales 