<prompt> Answer this question truthfullyCould you provide a definition or explanation for extramammary Pagets disease?  <response>: <reason> On gross pathology, a plaque with an irregular border and erythematous or white skin lesion are characteristic findings of extramammary Pagets disease. On microscopic histopathological analysis, Pagets cells large cells with abundant amphophilic or basophilic, finely granular cytoplasm, large centrally-located nucleus with prominent nucleolus and signet ring cells are characteristic findings of extramammary Pagets disease. Extramammary Pagets disease arises from keratinocytic stem cells or from apocrine gland ducts. Approximately 25 range 9-32 of the cases of extramammary Pagets disease are associated with an underlying in situ or invasive neoplasm. The neoplasm most likely to be associated with extramammary Pagets disease is an adnexal apocrine carcinoma, which usually represents infiltration of the deeper adnexa by epidermal Pagets cells. 