<prompt> Answer this question truthfullyWhat is the natural progression or development of Hereditary Nonpolyposis Colorectal Cancer?  <response>: <reason> If left untreated, hereditary nonpolyposis colorectal cancer progression occurs rapidly and is then followed by sentinel organ cancers or metastasis. Other organ cancers include: Genitourinary tract malignancies Endometrial carcinoma: 30 - 50 lifetime risk Ovarian tumors Urinary tract cancer Small bowel cancer: lifetime risk 5 Duodenum 45 Jejunum 29 Ileum 12 Not specified 14 Gastric cancer CNS tumors glioblastomaMore advanced stages are characterized by multiple organ metastasis.The 5-year relative survival of patients with hereditary nonpolyposis colorectal cancer is approximately 79.3. Complications that can develop as a result of hereditary nonpolyposis colorectal cancer are sentinel organ tumors, such as:Endometrial cancer. Gastric cancer Ovarian cancer Urinary tract cancers Small bowel cancers Central nervous system tumorsOther complications of hereditary nonpolyposis colorectal cancer are usually related to the colorectal surgery. 