<prompt> Answer this question truthfullyWhat does the term anemia of chronic disease mean?  <response>: <reason> The most important differential is whether the patient has ACD alone or ACD with ongoing iron deficiency anemia ACDIDA. The following parameters will distinguish the two: Soluble transferrin receptor levels sTfR andor the sTfR- ferritin index sTfR and the sTfR- ferritin index are normal in uncomplicated ACD, while both are elevated when IDA is also. Percentage of hypochromic red cells and reticulocyte hemoglobin may help. 