<prompt> Answer this question truthfullyWhat is the medical treatment for POEMS syndrome?  <response>: <reason> Patients with isolated bone lesion without bone marrow clonal plasma cells involvement can be treated with radiotherapy. Patients with a disseminated disease more bone lesions andor bone marrow plasmacytosis are the candidates for systemic therapy. Systemic therapy includes corticosteroids, autologous stem cell transplantation ASCT, induction therapy, alkylator-based therapy, thalidomide, lenalidomide, bortezomib, and bevacizumab. 