<prompt> Answer this question truthfullyWhat is the historical background or context of Waldenströms macroglobulinemia?  <response>: <reason> In 1936, Jens Bing and Axel Valdemar Neel, discovered a late and rare complication of Waldenstroms macroglobulinemia known as Bing-Neel syndrome BNS, who observed a case of 2 women, 56 and 39 years old, presenting with rapid neurodegeneration in the setting of hyperglobulinemia In 1944, Jan G. Gosta Waldenstrom, a Swedish doctor of internal medicine, first discovered Waldenstrom macroglobulinemia WM who reported an unusual presentation of fatigue, lymphadenopathy, bleeding from nose and mouth, worsening anemia, elevated sedimentation rate, low serum fibrinogen levels hypofibrinogenemia, hyperviscosity, and hypergammaglobulinemia in two patients due to increased levels of a class of an abnormal high molecular weight serum protein called macroglobulins In 1962, the first report on familial inheritance in WM was published, and since then many cohort studies as well as small case-control studies have been published showing familial aggregation of WM In 1994, a Revised European-American classification of lymphoid neoplasms REAL was published by International Lymphoma Study Group which placed WM in the category of lymphoplasmacytic lymphoma an indolent subtype of Non Hodgkins lymphoma and it is based on the morphology, immunophenotype, genetic and clinical features In 2001, WHO also classified the pathology of WM as lymphoplasmacytic lymphoma Waldenstrom macroglobulinemia based on REAL classification In September 26-30, 2002, a consensus group at the Second International Workshop on WM in Athens, Greece, defined WM as a distinct clinicopathologic entity with characteristics of bone marrow infiltration associated with IgM monoclonal gammopathy by WM and proposed a diagnostic criteria for WM In 2009, in Arkansas, a patient of Bing-Neel syndrome discontinued the treatment for BNS which included, intrathecal chemotherapy with several cycles of systemic chemotherapy followed by autologous BEAM transplant. In 2013, the patient was still asymptomatic when a follow-up report was published 