<prompt> Answer this question truthfullyWhat is the historical context of gestational trophoblastic neoplasia?  <response>: <reason> In 400 BC, Hippocrates is considered to be referring to gestational trophoblastic disease when he describeddropsy of the uterus. In 6th century, Aetius of Amida, a physician at Justinians court came up with the termhydatid. Next mention ofmole is from 1276 when Margaret, Countess of Henneberg, delivered approximately 300 babies on Good Friday the Friday before Easter Sunday. In 1827, Marie Anne Victoire Boivin, a Parisian midwife, proposed her findings of this condition inNouvelles Recherches de la Mole Visiculaire News Searches of the Vesicular Mole. In 1840, William Wilton reported a case of invasive mole that was complicated by uterine perforation and fatal internal hemorrhage. In 1867, Richard von Volkmann, a German surgeon, also described a lesion resembling an invasive mole. In 1877, Hans Chiari, an Austrian pathologist, reported three cases of choriocarcinoma. He recognized the tumors as epithelial. In 1888, Max Sanger, a German obstetrician, proposed his theory that these tumors were actually sarcomas deciduoma malignum. In 1890, Pfeiffer, a student of Hans Chiari, re-examined Chiaris cases and added a fourth case. He named them alldeciduoma malignum. In 1891, Pestalozza from Italy, reported three cases of a malignant uterine tumor associated with pregnancy. He described these cases assarcoma hemorrhagicum sen infectiosum. In 1895, Felix Jacob Marchand, a German pathologist, reported two cases and he proposed that the tumors were epithelial. He traced their histogenesis to the coats of chorionic villi, hence the termchorionepithelioma. In 1903, John Teacher presented a detailed account of Marchands work along with two cases of his own and a literature review of 100 cases. He persuaded the Obstetrical Society of London that chorionepithelioma was derived from trophoblast. In 1910, Ewing coined the termsyncytial endometritis to describe the exaggerated reaction of the placental site following hydatidiform mole. Studies at the National Cancer Institute by Li et al 1956 - 1958 established the efficacy of methotrexate against trophoblastic tumors. 