<prompt> Answer this question truthfullyWhat factors contribute to the risk of delayed puberty?  <response>: <reason> The most potent risk factor in the development of delayed puberty is hypothalamus - pituitary - gonadal HPG axis disturbance. Other risk factors are including genetic, endocrinologic, and environmental which may disturb the HPG axis.Common risk factors in the development of delayed puberty may be genetic, endocrinologic, and environmental. Common risk factors in the development of delayed puberty include: Family history of delayed puberty Genetics Chromosomal disorders Eating disorders Chronic illnesses Malnutrition Excess exercise Acquired gonadal disorders Pituitary surgery prior to puberty Chemotherapy Radiation therapy Sickle cell disease HemosiderosisLess common risk factors in the development of delayed puberty include: Congenital pituitary structural abnormalities Congenital testicular disorders Adrenal hypoplasia Histiocytosis Sertoli Cell only Syndrome Del CastillonSyndrome 