<prompt> Answer this question truthfullyCan you provide an overview of Extramammary Pagets disease?  <response>: <reason> Treatment depends on the stage at diagnosis. Chemotherapy with either 5-fluorouracil, imiquimod, or combination of paclitaxel and trastuzumab has been evaluated for the treatment of extramammary Pagets disease.Surgery is the first line treatment for extramammary Pagets disease.There are no primary preventive measures against extramammary Pagets disease.Secondary prevention strategies following extramammary Pagets disease include an annual complete physical examination, proctosigmoidoscopy and punch biopsy of any new lesion. Colonoscopy should be carried out at every two to three year intervals. 