<prompt> Answer this question truthfullyWhat is the history and what are the symptoms of Cryoglobulinemia?  <response>: <reason> Symptoms vary depending on the type of cryoglobulinemia and the organs involved. Symptoms of cryoglobulinemia may include: Difficulty breathing and coughRenal involvement is more common in type II than in type III. Nephrotic range proteinuria with edemaPurpura or skin ulcerAbdominal painNonspecific constitutional symptoms Fever Arthralgia, specifically affecting metacarophangeal, proximal phalangeal, knees and ankles. It worsens with exposure to the cold. Myalgia FatigueBlurring loss of vision Diplopia Confusion 