 Energy-dependent physical and biophysical constraints 10 RNA-Mediatedaccumulation of mutationsamino acid substitutionantigenic changescancer etiologycancer preventionchromosomal rearrangementsCorrelationcorrelation experimentsCytosisendogenously produced reactive oxygen speciesenergyenergy as informationepithelial-mesenchymal transitionEshel Ben-JacobEugene Kooninextremely fast decoherencefeedback loopsinfluenza virusinformation processing systemsinteractionmatterMethylationmicrobesmicrobial worldmicroRNAsMiguel Lopez-Lazaronatural productsnegative entropyodorolfactionother life formspheromone signalingphotosynthetic energy transferquantized energyquantum coherencequantum effects on base pairingquorum sensingRegulation of miRNAreproductionreproductively fit individualssense of smellsomatic mutation theorysunlightthermodynamic imbalancesTime Perceptionviral latencyvirus worldvirusesWatson-Crick-like mispairsWen Zhou 