 Model-based drug developmentAdaptive designMyelodysplastic syndromePopulation pharmacokinetics-pharmacodynamicsPhase I clinical trialDepartment of Pharmacology, College of Medicine, The Catholic University of Korea, Seoul, Republic of KoreaPIPET Pharmacometrics Institute for Practical Education and Training, Seoul, Republic of KoreaCatholic Blood and Marrow Transplantation Center, Seoul St. Marys Hospital, The Catholic University of Korea, Seoul, Republic of Korea 