 I-Lapatinib powder 231277-92-2 hplc 98 Yenza ama-Reagents we-R D Imikhiqizo Abanye I-Lapatinib powder i-231277-92-2SKU: 231277-92-2. Isigaba: AbanyeI-AASraw inokukwazi ukuhlanganisa nokukhiqiza amandla kusuka kugramu ukuya ku-mass mass ye-Lapatinib powder 231277-92-2, ngaphansi komthethonqubo we-CGMP kanye nesistimu yokulawula ikhwalithi.Lapatinib powder isiqophi UkugundaI-Lapatinib powder Izinhlamvu eziyisisekeloIgama: I-Lapatinib powderFormula Yamamolekhula: C29H26ClFN4O4SI-Melt Point: I-136-140 CI-Raw Lapatinib powder ku-Antineoplastic Agent cycleIgama elijwayelekile: I-Lapatinib powder la PA tin ibIgama logama: TykerbUkusetshenziswa kwe-Raw Lapatinib powderI-Lapatinib powder iyimithi yokwelapha esetshenziswa ngomunye umuthi capcitabine ukuphatha abantu ngomdlavuza webele oye wanda kwezinye izindawo zomzimba okuyi-HER2 enhle izicubu ezikhiqiza inqwaba yamaprotheni okuthiwa i-epidermal growth factor receptor-2 , futhi ngubani osevele enesinye imithi yomdlavuza webele.I-Lapatinib powder nayo isetshenziselwa uhlobo lwezokwelapha okuthiwa i-letrozole yokwelashwa kwabesifazane be-postmenopausal abane-hormone receptor positive, umdlavuza webele we-HER2 omuhle wezinyosi lapho i-hormonal therapy iboniswa khona.I-Lapatinib powder iyimithi yokwelapha esetshenziswa ekwelapheni umdlavuza webele. Isetshenziselwa ukuhlanganiswa neminye imithi yokwelapha uhlobo oluthile lomdlavuza webele olusakazekele kwezinye izingxenye zomzimba futhi olungaphenduli kwezinye izifo zomdlavuza.I-Lapatinib powder ingeqembu lezidakamizwa okuthiwa i-kinase inhibitors elisebenza ngokuvimbela isenzo seprotheyini ethile esho ukuthi amaseli omdlavuza aphindwe.Le mithi ivela efomini yethebhulethi futhi ithathwa kanye ngosuku ngalunye esiswini esingenalutho.Imiphumela emibi evamile ye-Lapatinib powder ihlanganisa izandla ezibomvu, ezibuhlungu nezinyawo, isifo sohudo, ukuqhuma, nokucabangela.Iyiphi isilinganiso seLatatinib powderUkusebenzisa i-Adult Dose for Cancer Breast-I-CANCER ihlanganiswa ne-capecitabine ye-HER2-POSITIVE ehlangene ne-capecitabine: 1250 mg ngomlomo kanye ngosuku ngezinsuku ze-1 kuya ku-21 ngokuqhubekayo ngokuphinda imijikelezo yezinsuku ze-21 kuze kuqhubeke ukuguquka kwesifo noma ubuthi obungavumelekile.I-HORMONE RECEPTOR-POSITIVE, I-HER2-POSITIVE METASTATIC BREAST CANCER ehambisana ne-letrozole: 1500 mg ngomlomo kanye ngosuku.-Ukuthola ulwazi lomkhiqizo womkhiqizo we-capecitabine nezincomo ze-letrozole dosing.-Iziguli ze-metastatic ze-metastatic zeHER2-positive kufanele zibe nokuqhubeka kwezifo ku-trastuzumab ngaphambi kokuqala ukwelashwa nalesi sidakamizwa ngokuhambisana ne-capecitabine.Ukusebenzisa:-Ukuhlanganiswa ne-capecitabine yokwelashwa kweziguli ezinomdlavuza ophuthumayo noma we-metastatic wezinambuzane ezinama-tumors overexpress HER2 nalabo abaye bathola ukwelapha kwangaphambi kokufaka i-anthracycline, itekane, ne-trastuzumab.-Ukuhlanganiswa ne-letrozole yokwelashwa kwabesifazane be-postmenopausal abane-hormone-positive positive metastatic umdlavuza webele we-hormone receptor-positive okuyinto ephazamise kakhulu i-HER2 receptor okuboniswa ngayo ukwelashwa kwe-hormonal.Ukulungiswa Kwama-Renal DoseIdatha ayitholakali mayelana nokulungiswa kwesilinganiso; Kodwa-ke, i-pharmacokinetics yalesi sidakamizwa cishe ayithintekile ngenxa yokuthi okungaphansi kwe-2 yesilinganiso esilawulwayo isuswa yizinso.Ukulungiswa kwesibindi UkulungiswaUMSEBENZI WOKUPHILA UKUPHILA UKUPHATHISA IMPILO YEZEMPILO I-CHILD-PUGH A B: Idatha ayitholakali.UKUPHUMA OKUPHILA KWE-HEPATIC IMPAIRMENT CHILD-PUGH C: Nciphisa umthamo:-HER2-Positive Canast Metastatic Breast Cancer ehambisana ne capecitabine: 750 mg ngosuku.-Hormone Receptor-Positive, HER2-Positive Metastatic Breast Cancer kuhlanganiswe ne letrozole: 1000 mg ngosukuKUNYE NE-HEPATOTOXICITY OCCURS NGOKUKHAMBA: Ukuyeka unomphela ukwelashwa.Amazwana: Izincomo zokulungiswa kwezintambo zisekelwe kwizifundo ze-pharmacokinetic; ayikho idatha yomtholampilo etholakalayo.Ukulungiswa kweDoseUMTHETHO WOKUSETSHENZISWA NABASEBENZI BE-CYP450 3A4 NOMA NOMA KANYE NABASEBENZI BE-CYP450 3A4: Gwema ukusebenzisa okuhambisanayo uma kunokwenzeka. Izincomo zokulungiswa kwezintambo zisekelwe kwizifundo ze-pharmacokinetic; ayikho idatha yomtholampilo etholakalayo.UMTHETHO WOKUSETSHENZISWA NESIKHATHI SESIKHATHI SIKHXXUMUMA 450A3 INHIBITOR: Nciphisa umthamo ku-4 mg ngosuku; vumela isikhathi se-shuttle cishe seviki le-500 ngaphambi kokulungiswa okuqhubekayo kwalesi sidakamizwa kumthamo ophakanyisiwe owenzelwe uma i-inhibitor ingaqediwe.UMTHETHO WOKUSETSHENZISWA NESIKHATHI SE-CYP450 3A4 INDUCER: Umthamo we-titrate okhuphuka kancane ngokusekelwe ekubekezekeni; ukunciphisa umthamo emuva kwenzalo evamile yokunconywa uma i-inducer ivaliwe.-HER2-Positive Cancer Metastatic Breast Cancer kuhlanganise ne capecitabine: Ukwandisa umthamo kuze kube yi-4500 mg ngosuku.-Hormone Receptor-Positive, HER2-Positive Metastatic Breast Cancer kuhlanganiswe ne letrozole: Ukwandisa umthamo kuze kube 5500 mg ngosuku.IGREYIDI 2 noma UKUQALA OKUHLELA KWEZINDLELA ZOKWENZA IZINDLELA ZOKUPHILA LVEF NOMA UKUPHILA OKUHLELA UKUQALA KWEMISEBENZI YOKUSEBENZA KWAMAZIKO: Ukuyeka ukwelashwa; ingase iqalise kabusha ngesilinganiso esinciphile ngemuva kokungenani kwamaviki angu-2 uma i-LVEF ibuyele evamile futhi isiguli singenakwenzeka.-HER2-Positive Canast Metastatic Breast Cancer ehlangene ne-capecitabine: 1000 mg ngosuku-Hormone Receptor-Positive, HER2-Positive Metastatic Breast Cancer kuhlanganiswe ne letrozole: 1250 mg ngosukuIBANGA 3 NOMA IBHAYIBHELI 1 noma i-2 DIARRHEA EZIPHUMA EZIPHUMELEKAYO ukulinganisela ukuya ekomelweni eliphansi kwesisu, i-Grade 2 noma i-nausea enkulu noma ukuhlanza, ukunciphisa isimo sokusebenza, umkhuhlane, isisu, i-neutropenia, ukuphuma kwe-frank, noma ukuphelelwa amanzi: Ungase uphinde uvuselele umthamo ophansi lapho uhudo ixazulula ku-Grade 1 noma ngaphansi.-I-patient ye-HER2-positive ye-Breast Metastatic Breast Cancer inhlanganisela ne-capecitabine: 1000 mg ngosuku-Hormone Receptor-Positive, HER2-Positive Metastatic Breast Cancer Iziguli: 1250mg ngosukuIBANGA LE-4 DIARRHEA: Unqume unomphela ukwelashwa.EZINYE IZIKHAYA, IBANGA 2 noma ELIKHULU: Kungabheka ukuyeka noma ukuphazanyiswa kokulandelwa; ingase iqalise kabusha ngesilinganiso esivamile sokunconywa lapho ubuthi obuphuthumayo bubonakala kuGreyidi 1 noma ngaphansi.Uma i-TOXICITY RECURS: Nciphisa umthamo:Yeka indlela i-Lapatinib powder engasebenzi ngayo esebenza ngayoI-Lapatinib powder isetshenziselwa i-capecitabine Xeloda yokwelapha uhlobo oluthile lomdlavuza wesifuba ophuthumayo kubantu abaye baphathwa ngezinye izidakamizwa zamakhemikhali. I-Lapatinib powder iseklasini lemithi ebizwa ngokuthi i-kinase inhibitors. Isebenza ngokuvimbela isenzo seprotheyini engavamile ekhombisa amangqamuzana omdlavuza ukuba aphindwe. Lokhu kusiza ukuma noma ukunciphisa ukusakazeka kwamangqamuzana omdlavuza.Tshela bonke abahlinzeki bakho bezempilo ukuthi uthatha i-Lapatinib powder. Lokhu kuhlanganisa odokotela bakho, abahlengikazi, abemithi kanye namazinyo.Uma uphethwe yisisu, ukuphonsa, izihlalo ezivulekile uhudo, noma abalambile, khuluma nodokotela wakho. Kungase kube khona izindlela zokunciphisa le mibi emibi.Izitofu ezilahlayo isifo sohudo zenzeke nePapatinib powder. Ngezinye izikhathi, isifo sohudo sibi kakhulu futhi ukufa sekuye kwenzeka. Khuluma nodokotela wakho.Uma unezihlalo ezivulekile uhudo, khuluma nodokotela wakho. Ungazami ukwelapha isifo sohudo ngaphandle kokuhlola kuqala udokotela wakho.Yenza umsebenzi wegazi uhlolwe njengoba utshele udokotela. Khuluma nodokotela.Kuzodingeka ube nokuhlolwa komsebenzi wenhliziyo ngenkathi uthatha i-Lapatinib powder. Khuluma nodokotela.Gwema i-grapefruit kanye nejusi lamagilebhisi.Uma uthatha digoxin, khuluma nodokotela wakho. Kungase kudingeke ukuthi umsebenzi wakho wegazi uhlolwe ngokuseduze uma uwathatha nge-Lapatinib powder.Le mithi ingalimaza ingane engakazalwa uma uyithatha ngenkathi ukhulelwe.Sebenzisa ukubeletha ongayethemba ukuvimbela ukukhulelwa ngenkathi uthatha i-Lapatinib powder.Uma ukhulelwe noma ukhulelwa ngenkathi uthatha i-Lapatinib powder, shayela udokotela wakho ilungelo.I-Lapatinib Raw PowderIngabe i-Lapatinib powder eluhlaza kunayo yonke imiphumela emibiKanye nemiphumela yayo edingekayo, i-Lapatinib powder ingabangela ezinye izinto ezingadingeki. Nakuba zonke lezi zemibala zingase zenzeke, uma zenzeke zingadinga usizo lwezokwelapha.Hlola nodokotela wakho ngokushesha uma kukhona okunye okulandelayo okumele kwenzeke ngesikhathi uthatha i-Lapatinib powder:Ukuphefumula okunzima noma okusebenzayoukushaya kwenhliziyo okusheshayo noma okungavamileisifo sohudo oluqinileukuqina kwesifubaukukhathala okungavamile noma ubuthakathakaUbuhlungu besisu noma isisu noma isisaizitshalo ezinobumbaukunciphisa ukudlaukushaywa noma ukukhwabanisa isikhumbaukulahlekelwa ukudlaukuvuvukala kwezinyawo noma imilenze ephansiamehlo aphuzi noma isikhumbaIsimo esingaziwaUkuqhaqhazela, ukukhipha, ukukhipha isikhumbaukhwehlelaumuzwa ovamile wokungahambi kahle noma ukugulaubuhlungu obuhlangene noma bomzimbaukukhukhumeza noma ukuvuvukala kwamajwabu amehlo noma eduze kwamehlo, ubuso, izindebe noma ulimiizilonda zesikhumba esibomvu, ngokuvamile ziyisikhungo esinomsunduamehlo abomvu, acasulayoizilonda, izilonda noma amabala amhlophe emlonyeni noma ezindebeniukuqina kwemfihlo yokwehlaEzinye imiphumela emibi ye-Lapatinib powder kungenzeka ukuthi ngokuvamile ayidingi ukunakekelwa kwezokwelapha. Le miphumela emibi ingase ihambe ngesikhathi ukwelashwa njengoba umzimba wakho ulungisa umuthi. Futhi, uchwepheshe wakho wokunakekelwa kwezempilo angakwazi ukukutshela ngezindlela zokuvimbela noma ukunciphisa ezinye zalezi zemibala. Hlola nge-professional care professional yakho uma ngabe kukhona eminye imiphumela emibi eqhubekayo noma ephazamisayo noma uma unemibuzo mayelana nabo:I-Acid noma isisu esisimuncuizindebe eziphahliweisifo sohudo omneneubuhlungu ezandleni noma emilenzeniubomvu, ukuvuvukala, noma isikhumba esibuhlunguukukala kwesikhumba ezandleni nasezinyaweniizilonda, izilonda noma izindawo ezimhlophe ezindebe, ulimi, noma ngaphakathi emlonyeniukungahambi kahle kwesisu, ukucasuka, noma ubuhlunguukuvuvukala noma ukuvuvukala komlomoukubetha kwezandla nezinyawoinkathazo yokulalaIndlela yokuthenga i-Lapatinib powder kusuka ku-AASrawI-Sorafenib 284461-73-0 