<qa>  What was the average dose of E2 in Turner syndrome teens?Pharmacokinetic study of transdermal E2 in Turner syndrome teens showed absorption of E2 by first order kinetics 9. Steady state was achieved approximately 9 hrs after application of a 37.5 μg patch, and serum concentrations reached a mean of 52.9 17.8 SD pgml. This demonstrates a rise in plasma estradiol of about 1 pgml 3.67 pmoll for every 1.0 μg applied to the skin, similar to package insert data in adults. This would suggest that a starting dose of 5-10 ug transdermal E2 daily approximates the 133-266 μg monthly amount of E2 delivered by the 0.2-0.4 mg monthly injections of E2 cypionate. 