<qa>  What is the resulting outcome of a progressive hormone-refractory disease?- Progressive hormone-refractory disease after orchiectomy or gonadotropin-releasing hormone analog andor anti-androgen treatment within 12 months of screening based on 1 of the following: Transaxial imaging tumor progression, Rise in 2 consecutive prostate-specifec antigen PSA values obtained at least 7 days apart or Radionucleotide bone scan progression 