<qa>  What is a subject with a clinical abnormality or laboratory parameters not specifically- Healthy as determined by a responsible and experienced physician, based on a medical evaluation including medical history, physical examination, laboratory tests and cardiac monitoring. A subject with a clinical abnormality or laboratory parameters which isare not specifically listed in the inclusion or exclusion criteria, outside the reference range for the population being studied may be included only if the Investigator, in consultation with the GSK Medical Monitor MM if required, agrees and documents that the finding is unlikely to introduce additional risk factors and will not interfere with the study procedures. 