<qa>  What is the CDAI determined by?6. Patients can be naïve to biologic therapy or have had exposure to TNF or biologic therapy see appropriate wash out schedule and be experiencing at least a moderate disease activity score as determined by a CDAI of 10 at Screening despite currently receiving Methotrexate therapy at a dose of 10-25 mgweekly for at least 12 weeks and at a stable dose for the past 4 weeks. 