<qa>  What is one of the top three causes of preventable death and disease in the US?Alcoholism is among the top three causes of preventable death and disease in the US Mokdad et al., 2004; Room et al., 2005. Stress plays an important role in the development of alcoholism and in high vulnerability to alcohol relapse. This study will provide a greater understanding of the mechanism by which stress and alcohol consumption interacts to influence development of compulsive alcohol seeking and vulnerability to stress-induced drinking, and the results will have significant implications for the development of new prevention and treatment interventions for alcoholism. 