<qa>  What is the goal of this study?The aim of this study is to investigate associations between early structural cellular injury and microvascular alteration with progression of septic organ dysfunction according to total SOFA-Score an ICU-scoring system - the Sequential Organ Failure Assessment Score. Patients will be monitored for renal TIMP-2, IGFBP7, and intestinal biomarkers plasma i-FABP in conjunction with kidney and muscle vascular bed microvascular perfusion analysis assessed by contrast-enhanced ultrasonography CEUS. In parallel, a comprehensive analysis of patients immunological status will be conducted using an established, on-site immune monitoring panel. 