<qa>  What is the main cause of the development of syndrome X?Overweight and obesity are rapidly becoming one of the most pressing health problems. Obese subjects face an increased risk for cardiovascular events that is closely related to a cluster of metabolic disturbances i.e. insulin resistance, hypertension, dyslipidemia and impaired fibrinolysis, collectively referred to as syndrome X. The actual mechanism underlying development of syndrome X has not been elucidated. Increased TNF-alpha activity has been proposed as a key factor. 