<qa>  How many subjects had an objective tumor response?A pilot study has been conducted in subjects with advanced HCC with portal vein invasion for which effective therapeutic methods have not been established. This was a single-center, open-label study of localized concurrent chemoradiation therapy CCRT for locally advanced HCC patients with portal vein invasion. A total of 40 subjects with advanced HCC with portal vein invasion were enrolled. The subjects were treated with a total of 45 Gy of external beam radiotherapy 1.8 Gy per session, 5 sessions a week, for 5 weeks, with hepatic arterial infusion of 5-flourouracil 5-FU during the first and last 5 days of radiation therapy 5-FU 500 mg infusion for 5 hours through the pre-inserted chemoport. Eighteen 45 subjects had an objective tumor response at 1 month after completion of localized CCRT. The 3-year survival rate was 24.2 and median overall survival was 13.1 months. 