<qa>  What is the maximum amount of time from prior cytotoxic therapy?3. less than 28 days from prior cytotoxic therapy except 23 days from prior temozolomide, 14 days from vincristine for GBM: 14 days from irinotecan or topotecan, 42 days from nitrosoureas, 21 days from procarbazine, irinotecan or topotecan administration; 