<qa>  What is the name of the type of cardiac problems that the physician judges could be detrimental to subjects4. Patient with grade IIIIV cardiac problems as defined by the New York Heart Association Criteria. i.e. congestive heart failure, myocardial infarction within 6 months before baseline Patient with any condition that the physician judges could be detrimental to subjects participating in this study; including any clinically important deviations from normal clinical laboratory values or concurrent medical events Previous treatment 