<qa>  What is the alternative to providing controlled anticoagulation embraced by Regado BioscienceAn alternative approach to providing controlled anticoagulation embraced by Regado Biosciences is the utilization of an anticoagulating agent with medium-term duration of action 12 hours that can achieve clinically appropriate activity at relatively low doses, in combination with a second agent capable of specifically binding to and neutralizing the primary anticoagulant. Such a drug-antidote combination can ensure predictable and safe neutralization and reversal of the anticoagulant activity of the drug Rusconi et al., 2004; Rusconi et al., 2002. 