<qa>  What is the potential toxicity of WBRT?The treatment management of single BM remains controversial. Indeed, even though it is widely accepted that local treatment increases the median survival time in patients having a good prognostic status, the adding of adjuvant whole-brain radiation therapy WBRT is currently subject to controversy, due to its potential toxicity. Yet, two randomized trials have demonstrated a clear increase in intra-cerebral recurrence and in death from neurologic origin in case of absence of adjuvant WBRT, without change in overall survival but overall survival was not a primary endpoint in any of these studies. 