<qa>  What is the cost of statin therapy?20 million Americans are actively treated with statins at an annual cost of 16 billion dollars. Statins are effective therapeutic agents for reducing LDL cholesterol and have documented effectiveness. However, a significant subset of patients 5-18, cannot tolerate lipid lowering statin therapy due to intolerable muscle-related symptoms characterized by muscle pain andor weakness. These symptoms affect quality of life and lead to poor adherence. 