<qa>  To determine the complete remission CR cytogenic complete remissionI. To determine the complete remission CR cytogenic complete remission CRc morphologic complete remission with incomplete blood count recovery CRi rate of carboplatin and topotecan; flavopiridol, mitoxantrone and cytosine arabinoside and sirolimus, mitoxantrone, etoposide and cytosine arabinoside in adult patients with refractory or relapsed acute myeloid leukemia AML. 