<qa>  What is the minimum PSA of the Subjects with Stage III or Stage IV prostate cancer?10. Subjects with Stage III or Stage IV prostate cancers who have received and not responded to radiation therapy, surgery if applicable and hormonal therapy, and are hormone-refractory. Subjects must have two consecutive PSA values, at least 14 days apart, each 5 ngml and 50 above the minimum PSA observed during castration therapy or above the pretreatment value if there was no response. 