<qa>  What is the effectiveness of cryoprotection of onycholysis secondary to DocetThe effectiveness of cryoprotection of onycholysis secondary to Docetaxel is not well established in this population breast cancer in the adjuvant setting and is based solely on a publication Scotté that does not contain the same therapeutic modalities dose significantly higher. The few studies available have heterogeneous populations, nonrandomized, retrospective or with a small sample. 