<qa>  What is the name of the type of biliary abnormalities that are known?6. Patients with severe hepatic impairment or unstable liver disease as defined by the presence of ascites, encephalopathy, coagulopathy, hypoalbuminaemia, oesophageal or gastric varices, or persistent jaundice, known biliary abnormalities with the exception of Gilberts syndrome or asymptomatic gallstones 