<qa>  What is the main reason for the lack of randomization techniques?All studies published to date addressing the role of systemic antibiotics and M3 removal have one or more major methodological flaws in study design characterized as :1 no or ambiguous definition of the outcome variable, 2 inadequate sample size, 3 non-uniformity of protocol design, 4 lack of randomization techniques and 5 poor-follow-up monitoring. Clearly, there is a need for a definitive, rigorous, well-designed placebo-controlled randomized clinical trial to ascertain the efficacy of systemic antibiotics in preventing postoperative inflammatory complications after M3 removal. 