<qa>  What is the maximum limit of normal of Aspartate Aminotransferase9. Clinically significant abnormalities of hematology or biochemistry as confirmed by repeat testing based on investigators discretion, including but not limited to, elevations greater than 2 times the upper limit of normal of Aspartate Aminotransferase AST, Alanine Aminotransferase ALT, Alkaline Phosphatase ALP or creatinine clearance less than 60 mlmin at screening via estimated Cockcroft-Gault formula: 