<qa>  What is the effect of neoadjuvant regimens on the response rateTo evaluate the effect of both neoadjuvant regimens on clinical and pathological response rate in particular relief of dysphagia, improvement in health related quality of life HRQL, endoscopic regression, and CT-PET evidence of tumour response, tumour regression grade, node-positivity, post-operative pathology, disease-free survival, time to treatment failure, toxicity, post-operative complications and Health Related Quality of Life HRQL. 