<qa>  What is the effect of guanfacine on cocainealcohol craving?This study aims to test the preliminary efficacy of 3.0 mg of guanfacine GFC daily versus placebo in cocaine andor alcohol dependent individuals. This proposal is a laboratory and treatment outcome study to examine the effects of guanfacine on brief exposure to stress, drug cues and neutral situations on cocainealcohol craving, mood and neurobiological reactivity in a sample of cocaine andor alcohol dependent individuals. Guanfacine will be beneficial for reduction in stress and drug cue induced craving and related arousal. In a sample of 60 cocaine andor alcohol dependent men and women, we propose to examine a differences in measures of cocaine craving, emotion state, hypothalamic-pituitary-adrenal HPA activation, physiological arousal and plasma catecholamine response to stress imagery and to drug cue imagery as compared to neutral imagery; b reduction in cocainealcohol abstinence symptoms; and c improvement in cocaine and alcohol treatment outcomes as measured by increasing abstinence, reduction in cocainealcohol use and increased treatment attendance. Hypothesis 1: Guanfacine will decrease stress-induced cocaine craving, negative emotions and related arousal in the laboratory as compared to placebo. Hypothesis 2a: As compared to the PLA group, the GFC group will show significant reductions in protracted withdrawal symptoms as measured by the CSSACIWA during the 9-week treatment period. 