<qa>  What is the primary recruitment venue for the Neurology clinics?All patients trios both parents patient with IIS trio with IIS retrospectively identified to have been treated with ACTH according to FDA-approved protocol will be eligible for inclusion in this study regardless of age, sex, ethnicityrace, or socioeconomic status. The principal recruitment venues will be Neurology clinics, in-patient service and Medical Genetics Clinics at Childrens Hospital Colorado and University of Colorado Health Sciences Center UCHSC 