<qa>  What is the most advisable choice for GER management in symptomatic preterm infantsIn the last decade, GER pharmacological treatment has increasingly widespread in Neonatal Intensive Care Units NICUs. The provision of anti-histamine2 blockers and proton pump inhibitors in the preterm population, however, might lead to such adverse effects as an increased incidence of necrotizing enterocolitis and infections. Hence, to avoid a useless and potentially harmful pharmacological overtreatment, a step-wise approach, firstly promoting conservative strategies, is currently considered the most advisable choice for GER management in symptomatic preterm infants. 