<qa>  What is the first time a patient has been treated with symptomatic brain metastases1. Patients with untreated or symptomatic brain metastases. Patients with treated, asymptomatic brain metastases are eligible if there has been no change in brain disease status for at least four 4 weeks, no history of cerebral oedema or bleeding in the past four 4 weeks. Steroids will be allowed. Anti-epileptic therapy will be allowed if no changes are anticipated within the initial 14 days of treatment QTC-evaluation. 