<qa>  What is the cutaneous toxicity expected with this modulated schedule?At the same time, lower cutaneous toxicity is expected with this modulated schedule due to the possibly increased cellular repair. Pharmacokinetics data of Cetuximab we found on the population: Vmax 4.38mgh 15.4, Km 74gml, central compartment volume Vl 2.83 l 18.6, peripheral compartment volume 2.43 l 56.4 and intercompartmental clearance 0.103 lh 97.2. Those parameters remain unmodified also during prolonged therapies. Administrated doses have been found to be adequate to cell wall receptors saturation. 