<qa>  What is the dose of sodium valproate?Phase 1, The Acute Phase. Index medications schedule. Following randomization, during the first 8-week phase, the index manic episode will be treated with either adjust lamotrigine or sodium valproate will be started at 25 mg po daily and will be increased biweekly until a maximal dose of 200 mgday. Dose escalation schedule: weeks 1-2 25 mg po qd, week 3-4 25 mg po bid, weeks 5-6 50 mg po bid, weeks 7-8 100 mg po bid. The dose could be decreased to as low as 50 mgday to reduce side effects other than rash. The sodium valproate treatment will be initiated with a loading dose of 20 mgkg, and the dose will be adjusted in 250 mgday increments to achieve a therapeutic level of 100-120 mcgkg. 