<qa>  What is the current dogma?The existing dogma is that patients receiving highly active antiretroviral therapy HAART to treat their HIV infection must take at least 95 of prescribed doses in order to maintain full suppression of viral replication. This belief is largely based on a single study that was performed between 1997 and 1999 Ann Int Med 2000;133:21-30. The vast majority of patients in this study were receiving regimens based on either indinavir, nelfinavir, ritonavir, or saquinavir. All of these agents have relatively short half-lives, and therefore must be taken on time two or three times per day. Newer medications such as lopinavirritonavir Kaletra feature much more favorable pharmacokinetic profiles. On the basis of improved pharmacokinetics, there is reason to believe that regimens built around such agents may be more forgiving of missed medication doses. 