<qa>  What is the gene for TNF-alpha controlled by?TNFeradeTM is a replication deficient adenovirus vector containing the gene for TNF-alpha controlled by a chemoradiation inducible promoter. This allows the expression of TNF-alpha to be greatest in the area receiving radiation. TNF-alpha is a cytokine that has been shown to have potent anti-cancer activities but, due to systemic toxicity, could not be delivered at effective doses. TNFeradeTM Biologic is a novel way of selective delivery of TNF-alpha to tumor cells. 