<qa>  What is the main reason males and females of child-producing potential must use adequate contra- Sexually active males and females of child-producing potential, must use adequate contraception intrauterine devices, hormonal contraceptives contraceptive pills, implants, transdermal patches, hormonal vaginal devices or injections with prolonged release or diaphragm always with spermicidal jelly and a male condom for the study duration and at least six months afterwards 