<qa>  What is the maximum dose of anti-cytotoxic T-lymphocyte-associated antigen- Determine the maximum tolerated dose MTD of anti-cytotoxic T-lymphocyte-associated antigen-4 monoclonal antibody MDX-CTLA4 in combination with high-dose interleukin-2 IL-2 in patients with metastatic melanoma. Phase I is closed to accrual as of 4132004. 