<qa>  What is the fundamental role of the RAAS in cardiovascular disease?Aldosterone and cardiovascular disease: The fundamental role of the RAAS in cardiovascular disease is apparent from the results of many large ACE inhibitor trials. In patients with chronic heart failure and in those with or at high risk of coronary artery disease, ACE inhibitors improve survival, functional status and hospitalisation. These beneficial effects have been attributed to prevention of the multiple adverse effects of ANG II. More recently, evidence has accumulated in support of an important role for aldosterone. 