<qa>  What is the degree of gene expression modulation by atorvastatin?Objectives: Overall: To determine if atorvastatin modulates gene expression in peripheral blood mononuclear cells in a dose dependent manner in a cohort of subjects at risk of vascular disease. Specific: To determine if: 1 Inflammatory genes are specifically and temporarily modified by atrovastatin in a dose dependent manner; 2 A previously defined panel of 78 genes is included among the genes modified by atorvastatin; and 3 Gene expression changes correlate the degree of gene expression modulation by atorvastatin with the degree of lipid lowering and other inflammatory parameters such as high sensitivity C-reactive protein. 