<qa>  What is the maximum tolerated dose?Patients with pre-treated measurable metastatic gastric cancer were included in this trial. Patients received this combination chemotherapy repeated every 28 days until progression disease. Starting dose dose level 1 were CPT-11 80 mgm2 on day 1 and 15, Paclitaxel 60 mgm2 on day 1 and 15. DLT was defined as follows according to NCI-CTC version 2.0; Grade 4 neutropenia, thrombocytopenia25000, Grade 3 neutropenia accompanied fever 38C , and Grade 3 non-hematological toxicity except for nausea, vomit, appetite loss , general fatigue, alopecia. Maximal Tolerated Dose MTD is determined when the incidence of critical toxicity exceeds 50 at a certain dose level. Response rate will be calculated according to RECIST criteria. 