<qa>  What is the NCI common toxicity criteria?Safety profile: Safety will be analysed in each treatment group. Patients having received 1 treatment doses are evaluable for toxicity. Evaluation will be performed on the safety population having received treatment, assignment to treatment groups as treated. Clinical and laboratory toxicitysymptomatology will be graded according to NCI common toxicity criteria, version 3.0. The adverse events which are not reported in NCI common toxicity criteria will be graded as: mild, moderate, severe, life threatening. 