<qa>  What is the target of the trial?- The study will be conducted as a two-stage optimal design Simon 1989. With alpha0.10 and beta0.10 as acceptable error probabilities, the trial will target 30 as the desirable proportion of patients who are still without progression by radiographic criteria at approximately 6 months p10.30, and will be considered inadequate if only a fraction consistent with 10 are without progression by the same evaluation time p00.10. Initially 12 patients will be enrolled and followed for progression. If 2 or more of the first 12 patients reach 6 months without progression, then enrollment will continue until a total of 35 evaluable patients 37 total patients to allow for a small number of inevaluable patients have been entered. 