<qa>  What is the main objective of this study?2. There is significant individual variation among the healthy population in endogenous thrombin generation due to known and unknown polymorphisms within coagulation proteins. We predict that host variables in thrombin generation will contribute to susceptibility to DIC and poor outcome during sepsis. A secondary objective of this study is to determine if host coagulation variables predispose to the morbidity and mortality associated with sepsis. 