<qa>  What is the cost of treating CVC related BSI estimated to be in excess of 2The use of central venous catheters CVC is paramount to the care of critically ill children. Thus, in the pediatric intensive care unit PICU, these catheters are widely used in situations when more than peripheral venous access is necessary. This central access allows the delivery of fluids, e.g, blood, medications, etc. as well as serves as a means to withdraw blood. It has been estimated that more than 250,000 nosocomial bloodstream infections occur each year, with 90 of these associated with the use of CVCs. More recently, the National Nosocomial Infection Surveillance System NNIS reported during 1992-2001 CVC-associated bloodstream infections BSI in ICU settings occurred at rates of 2.9-11.3 BSI per 1,000 catheter days. The cost of treating CVC related BSI has been estimated to be in excess of 28,000 per catheter. In the adult medical literature, there is strong evidence supporting use of antiseptic or antibiotic coated catheters to reduce the cost of hospitalization for CVC related infections. Cost-benefit studies have suggested that if the baseline incidence of CVC BSI is 0.4 BSI per 1000 catheter days, 59,000 will be saved, 7 cases of BSI will be avoided, and 1 death prevented for every 300 anti-septic impregnated CVCs used. 