<qa>  What is the name of the study that demonstrates the association between polymorphisms inEpidemiological studies of genome wide association study GWAS, candidate gene association, and linkage disequilibrium suggest that AMD has a significant genetic component.7-10 Ample evidence supports the hypothesis that variance of genes involved in DNA repair,11-13 oxidative stress14, 15 and inflammation16-20 play a role in aging and age-related diseases. Many studies have documented the association between polymorphisms in complement factors CF, oxidative stress, apolipoprotein E ApoE, mitochondria and chaperone proteins genes and AMD.21-23 Single nucleotide polymorphism SNP in ApoE, ApoE or C2BF may protect AMD. On the other hand, SNP in CFH, AMRS2HTRA-1 or CX3CR1 gene may increase AMD risk.24 In this study, we would like to test whether the variations of biologically plausible genes or the modifying genes listed above are differentially distributed in AMD patients and normal populations. To this end, we choose genes that are believed to play a crucial role in the aging process and will analyze the frequency of SNPs specifically within the coding frames of biologically plausible genes responsible for aging and age-related diseases. 