<qa>  What is the name of the neoadjuvant combination chemotherapy regimen?During the last decade, chemotherapy in metastatic colorectal cancer mCRC has made considerable progress.However, approximately 25 of patients with colorectal cancer present with overt metastatic disease. In selected patients, synchronous or metachronous liver metastases LM can be resected in curative intention. Over the last 5 years there has been the recognition that preoperative, neoadjuvant, combination chemotherapy regimens, namely, 5-fluorouracilfolinic acid 5-FUFA in combination with either irinotecan or oxaliplatin can facilitate to downsize the initially unresectable LM and make the resection possible. The addition of targeted therapies might render them even more effective. 