<qa>  What type of disease would affect patients compliance?- Severe, uncontrolled medical condition that would affect patients compliance or obscure the interpretation of toxicity determination or adverse events, including active severe infection, uncontrolled diabetes, angiocardiopathy heart failure class II NYHA, heart block II grade, myocardial infarction, unstable arrhythmia or unstable angina within past 6 months, cerebral infarction within past 3 months or pulmonary disease interstitial pneumonia, obstructive pulmonary disease or symptomatic bronchospasm. 