<qa>  What is the heightened risk of cardiovascular disease determined by?1.1. Body weight 50 kg or Body Mass Index BMI 18 or 30 kgm2 at screening. 1.2. A heightened risk of cardiovascular disease, as determined by: an estimated ten year risk of fatal cardiovascular disease of 5 at screening, as determined by the Systematic Coronary Risk Evaluation SCORE; history, or evidence at screening, of clinically significant arrhythmias, prolonged QT-interval or other clinically relevant ECG abnormalities; or a positive family history of cardiac events in 1st or 2nd degree relatives 50 years old. 