<qa>  What is the common cause of a disproportionate increase in CV risk in CKD?Traditional risk factors inadequately explain the disproportionate increase in CV risk in CKD. Hypovitaminosis D is common in CKD and associated with increased CV mortality. In animal experiments, vitamin D reduces LV mass LVM and improves systolic function. In dialysis patients, observational studies show that vitamin D therapy reduces CV mortality and improves diastolic function. However, benefit of native vitamin D repletion on cardiac structure and function has not been investigated in humans. 