<qa>  What is a symptomatic manifestation of agitated states?- Subject has a current, controlled requiring a restricted medication or uncontrolled, comorbid psychiatric diagnosis with significant symptoms such as any severe comorbid Axis II disorder or severe Axis I disorder such as Post Traumatic Stress Disorder, psychosis, bipolar illness, pervasive developmental disorder, severe obsessive compulsive disorder, severe depressive or severe anxiety disorder or other symptomatic manifestations, such as agitated states, marked anxiety, or tension. 