<qa>  What is the dose limit toxicity for the first 2 strata?If neutropenia is the dose-limiting toxicity DLT for the first 2 strata, patients are further stratified according to concurrent G-CSF support yes vs no.Cohorts of 3-6 patients in each stratum receive escalating doses of temozolomide with G-CSF until the MTD is determined. The MTD is defined as the dose preceding that at which at least 2 of 3 or 2 of 6 patients experience DLT. Once the MTD is determined, 6 additional patients are treated at that dose. 