<qa>  What is the ligand for P-, E-, and L-selectSelectins have been implicated in the pathogenesis of ischemiareperfusion IR-induced kidney injury and resultant DGF. PSGL-1 is a ligand for P-, E-, and L-selectin. It has been reported that that YSPSL rPSGL-Ig blocks P-selectin and, to a lesser degree, E- and L-selectin. Both sPSGL-1 and YSPSL rPSGL-Ig have been shown in animal models to reduce both cytokines and tissue damage associated with ischemia reperfusion and to improve renal function post-transplant. Therefore, the current phase III clinical study is designed to assess the safety and efficacy of YSPSL rPSGL-Ig in preventing DGF in patients undergoing cadaveric kidney transplants and to determine a dose for future pivotal studies. 