<qa>  What is the maximum creatinine clearance of the serum?3. Clinically significant laboratory abnormalities, including, but not limited to: Positive Hepatitis B surface antigen or Hepatitis C antibody, Positive HIV test, Serum alanine aminotransferase ALT greater than or equal to 2.0 x ULN, Serum creatinine greater than or equal to 2.5mgdL or calculated creatinine clearance less than or equal to 30mLmin. 