<qa>  What is the cause of uncontrolled asthma?2. Subject has a history or presence of uncontrolled andor clinically important pulmonary including uncontrolled asthma, cardiac, hepatic, renal, gastrointestinal, endocrine, hematologic, immunologic, neurologic such as Alzheimers or Parkinsons patients, psychiatric including depression andor anxiety disorders or biliary disorders. 