<qa>  What is the hypothesis that in-utero hyperandrogenism primes differentiatingPrimate studies have offered credence to the theory that genomic imprinting is influenced by environmental hyperandrogenism and the hypothesis of intra-uterine exposure to excess androgens as a cause of PCOS is gaining momentum Abbott et al, 2010. At birth, both mother and neonate are influenced by an identical hormone profile, and it is therefore expected that sebum excretion rates a correlate of androgen excess will be higher in those neonates born to mothers with PCOS when compared to those without. This would account for the observed familial transition of PCOS Legro et al, 1998; Vink et al, 2006, and support the hypothesis that in-utero hyperandrogenism primes differentiating tissues for later expression of the PCOS phenotype in adolescence. 