<qa>  What is the frequency and severity of adverse events classified and graded with?I. Estimate and compare the probabilities of response rate objective response rate ORR, either partial or complete response defined by Response Evaluation Criteria in Solid Tumors RECIST version v1.1 criteria on each study regimen. Phase II study II. Estimate the frequency and severity of adverse events as classified and graded with Common Terminology Criteria for Adverse Events CTCAE v.4.0 in those patients who initiate their randomly assigned study treatment. Phase II study III. Estimate and compare ORR in each treatment group. Phase III study IV. Estimate the frequency and severity of adverse events in those patients who initiate their randomly assigned study treatment. Phase III study V. Estimate and compare mean patient reported outcome scores PROs as measured by National Comprehensive Cancer Network NCCN-Functional Assessment of Cancer Therapy FACT ovarian symptom index NFOSI-18 disease-related symptoms DRS. Phase III study VI. Estimate and compare the treatment groups on the basis of the PROs: treatment side effects TSE, functionwell-being FWB, fatigue Functional Assessment of Chronic Illness Therapy FACIT-fatigue F subscale and abdominal discomfort FACTGynecologic Oncology Group GOG-abdominal discomfort AD subscale. Phase III study 