<qa>  What is the first cycle of docetaxel chemotherapy?Clinical study: A diagnostic core biopsy will be performed prestudy, and tissue obtained from this will be available for analysis. Other required baseline investigations, including CBC, kidney function tests, liver function tests, EKG, and pregnancy tests, are part of the standard of care. Docetaxel Taxotere 100 mgm2 is to be administered on day 1. A core biopsy is to be performed one day after chemotherapy day 2 and on days 8, 15 and 22. On day 22, after repeat core biopsy, a second cycle of docetaxel Taxotere chemotherapy 100 mgm2 will be given. Docetaxel Taxotere will be given three-weekly for a total of four cycles. Primary surgery will then be conducted, if operable, following completion of neoadjuvant treatment. Adjuvant AC doxorubicin 60 mgm2 and cyclophosphamide 600 mgm2, every three weeks for four cycles will then be administered. Adjuvant radiotherapy will be considered following completion of AC chemotherapy. Patients whose tumors were ER andor PgR positive would be commenced on tamoxifen for five years after completion of AC chemotherapy. 