<qa>  What are the most important clinical entities of the tumors?Gastroenteropancreatic neuroendocrine neoplasia GEP-NEN were considered for years as rare tumors. In last years however, their incidences are increasing 3,65 100.000 year Lawrence et al., 2011; Friling et al, 2014. These tumors are important clinical entities: 1 40-95 of tumors have metastasized at diagnosis, 2 evidence-based data dealing with the therapeutic strategy and screening are still scarce. 