<qa>  What is the main reason for the gap in the literature?While there is a literature, albeit small, examining the effects of caffeine on cognition and brain activity in healthy individuals, such research reports are all but non-existent in SZ based on extensive searches with both PsycINFO and PubMed. This gap in the literature is particularly notable given the rates of caffeine consumption observed within SZ. The sole studies to address how caffeine might impact cognitive processes in SZ have done so within animal models employing MK-801 a potent NMDA receptor antagonist infused mice. Within this behavioural model of SZ, chronic treatment with caffeine improved measures of long term memory, while reducing MK-801-induced perseverative errors in one study, while another study found no effects of chronic caffeine on cognition in mice given a significantly higher dose of MK-801. 