<qa>  What is the PEP-NG?Specific aims are at three levels. 1 To design an interface for the PEP-NG with: a desirable characteristics for both older adults and primary care providers; and b minimal user burden. 2 To show that APRNs will increase: a knowledge concerning potential drug interactions arising from older adults self-medication practices; b self-efficacy for teaching older adults about potential drug interactions; c self-efficacy for communicating with older adults about self-medication; and to d demonstrate satisfaction using the PEP-NG with clients. 3 To show that older adults using the PEP-NG will: a increase knowledge concerning potential drug interactions arising from self-medication practices; b increase self-efficacy as to how to avoid potential drug interactions arising from self-medication practice; c reduce self-reported adverse behaviors associated with potential drug interactions; 4 improve prescription medication adherence; d achieve target blood pressure readings; and demonstrate e satisfaction with the PEP-NG and f the APRN provider relationship. User-sensitive inclusive design methods will be used to develop and test the patient data interface. After beta-testing the PEP-NG in the primary care laboratory, the PEP-NG will be piloted by 10 APRNs affiliated with ProHealth primary care practices. Repeated Measures Analysis of Variance RM ANOVA with one within subjects factor TIME will be performed on APRNs outcome measures at time 0, immediate post-instruction, and 3 and 6 months later. APRNs will each recruit 24 clients 240 total meeting study criteria. The PEP-NG software will randomly assign each APRNs clients to either control data collection only and experimental data collection plus educational intervention with targeted messages. Client outcome will be assessed at 0, 4, 8, 12, and 52 weeks and analyzed as a mixed ANOVA with NURSE and GROUP as between-subjects factors and TIME as a repeated-measures factor. Healthcare utilization will be compared between the 2 groups after 52 weeks and a cost-benefit analysis conducted. 