<qa>  What is the recommended dose preceding the MTD?Cohorts of 3-6 patients receive escalating doses of IL-2 until the maximum tolerated dose MTD is determined. The MTD is defined as the dose at which at least 2 of 3 or 2 of 6 patients experience dose-limiting toxicity. The recommended dose RD is the dose preceding the MTD. Additional patients are treated at the RD. 