<qa>  What is the effect of romidepsin on female subjects?7. All females of childbearing potential must use an effective barrier method of contraception either an intrauterine contraceptive device IUCD or double barrier method using condoms or a diaphragm plus spermicide during the treatment period and for at least 1 month thereafter. Male subjects should use a barrier method of contraception during the treatment period and for at least 3 months thereafter. Female subjects should avoid the use of estrogen-containing contraceptives, since romidepsin may reduce the effectiveness of estrogen-containing contraceptives. An in vitro binding assay determined that romidepsin competes with β-estradiol for binding to estrogen receptors. 