<qa>  What is the primary objective of JS-001?The secondary objectives are to: 1 characterize the single-dose and multi-dose pharmacokinetic PK profile of JS-001, 2 characterize the immunogenicity of JS-001; 3 assess the dose-efficacy relationship of JS-001 single agent, and 4 preliminarily evaluate biomarkers associated with the efficacy of JS-001. 