<qa>  What is the escalation schedule for patients?Patients will be enrolled in cohorts of 3 according the dose escalationde-escalation rules specified. For the purposes of executing the dose escalation scheme, toxicity will be assessed until 4 weeks after treatment. Additional patient cohorts will not be enrolled until all toxicity evaluable patients treated at the current dose have completed the observation period. In addition, the investigators will pause after completion of the 800 mgm2, if the MTD is not reached, to assure that delayed toxicities dont manifest. If the MTD is not exceeded at the highest dose level, the escalation schedule may be expanded. 