<qa>  What is the working significance level for all statistical evaluations in this part of the study?The statistical parameters for controlling the overall response rates and for testing the CR rates are chosen in the following way: The working significance level for all statistical evaluations in this part of the study will be set to alpha0.05. The expected CR rate after R-CHOP is according to the observations about 50; a clinical relevant improvement by R-FC would be a CR rate of 65. Such an improvement should be detected by the one sided Fisher test with a power of about 95. According to these parameters about 246 observations for each treatment would be necessary. To control the overall response rates, a difference of 85 to 95 will be clinically so relevant that initial randomisation should be terminated with a probability of about 95. Overall response rates will be controlled by a restricted sequential procedure. 