<qa>  What is the maximum dose of cyclophosphamide and doxorubiPatients will be off study if Gr III toxicity persists 3 weeks after due day. Patients are allowed to use H3-blockers in the subsequent courses for severe nausea and vomiting. If gastrointestinal toxicity is still Gr III during the next course, doses of cyclophosphamide and doxorubicin should be reduced by 25 in the subsequent courses. If no further episodes of severe reaction, the doses can be escalated, 12.5 each time, and back to 100. 