<qa>  What is the strategy of SNB as good as DBB?The following research questions will be explored: Do sequential nephron blockade SNB and dual blockade of the renin-angiotensin-aldosterone system plus bisoprolol DBB constitute good therapeutic options in the reduction of peripheral blood pressure of patients with RH? Which therapeutic option is able to reduce the central BP of resistant hypertensive patients? Is the strategy of SNB as good as DBB? Objectives: This study will compare two antihypertensive treatment regimens in RH patients of the Medical School in Sao Jose do Rio Preto. It aims to demonstrate the therapeutic efficacy of SNB against DBB in RH patients, and to assess the side effects, and adherence to therapy over 20 weeks of treatment. 