<qa>  What was the initial glucose distribution volume?Methods and Results: Ten participants 251 years; BMI 231 kgm2; fasting glucose 832 mgdL received either placebo or 3 pmolkgmin BNP 32 intravenously for 4h. One hour after beginning the BNPplacebo infusion, a 3h intravenous glucose tolerance test 0.33 gkg glucose 0.03 Ukg insulin at 20 min was performed and plasma glucose, insulin and C peptide were frequently measured. BNP increased the initial glucose distribution volume 131 BW vs. 111, P0.002, leading to an overall reduction of glucose concentration P0.001 especially during the initial 20 min of the test P0.001, accompanied by a reduction of the initial C peptide levels 4.30.4 ngmL vs. 4.90.3, P0.015. BNP had no impact on beta cell function, insulin clearance or insulin sensitivity. 