<qa>  What is the name of the type of heart disease that is clinically significant?Clinically significant cardiovascular disease such as uncontrolled hypertension with systolic BP greater than 160 mmHg or diastolic blood pressure greater than 95 mmHg, unstable angina, New York Heart Association grade II or greater congestive heart failure, cardiac arrhythmia requiring medication, clinically significant peripheral artery disease, grade II or greater peripheral vascular disease, myocardial infarction. 