<qa>  What is the term for 24 hour urine protein excretion?Nephrotic range proteinuria that persists despite angiotensin antagonist therapy ACE inhibitor or ARB for at least on month, unless intolerant. If patients have not started ACE inhibitor therapy before they are referred to NIH, we plan to start lisinopril 5 mg daily. We will advance the dose of ACE inhibitor as tolerated. Nephrotic range proteinuria, defined as 24 hour urine protein excretion greater than or equal to 3.5 gd, must be documented in at least two 24 hour urine collections obtained during the month prior to initiating sirolimus. Incomplete urine collections based on inadequate creatinine excretion will be excluded. 