<qa>  What is the maximum tolerated dose?Patients with untreated measurable metastatic esophageal cancer were included in this trial. Patients received this combination chemotherapy repeated every 28 days until progression disease. Starting dose dose level 1 were docetaxel 50 mgm2 on day 1, fixed dose intravenously cisplatin 15 mgm2day and continuous infusion 5-FU 800 mgm2day on day 1-4. DLT was defined as follows according to NCI-CTC version 2.0; Grade 4 neutropenia lasting for more than 4days, Grade 4 anemia and thrombocytopenia, Grade 3 neutropenia accompanied fever 38C , and Grade 3 non-hematological toxicity except for nausea, appetite loss , general fatigue. Maximal Tolerated Dose MTD is determined when the incidence of critical toxicity exceeds 50 at a certain dose level. Response rate will be calculated according to RECIST criteria. 