<qa>  What is the CKD defined as?3. Has severe CKD, defined as eGFR 15 mLmin1.73 m2 and 29 mLmin1.73 m2 based on the IDMS traceable15 MDRD equation, according to laboratory results at Screening non-HD patients only Part 1. Patients with a prior history of greater than 2 weeks of dialysis in the past and who have dialyzed in the 6 months prior to dosing on Day 1 will be excluded. Patients who have had temporary dialysis for acute kidney injury will be allowed at the discretion of the Investigator. 