<qa>  What is the SEACAT 01 protocol?Resistance of Plasmodium falciparum to anti-malarial drugs is a serious impediment to malaria control. In the South East African Combination Anti-malarial Therapy SEACAT evaluation, there is an evaluation of the phased introduction of combination anti-malarial therapy CAT in Mozambique, Swaziland and South Africa. In order to facilitate formulation of effective regional drug policy and provide a database for decision-making on the implementation of CAT, it is essential that the in vivo response to CAT be investigated. This will be achieved through the SEACAT 01 protocol which is a component of the SEACAT evaluation described in another file on this website. However, in selected Mozambique sites where the intensity of malaria transmission is high, a direct parallel group comparison of monotherapy SP with CAT artesunate, AS, plus SP will be conducted according to a specific amendment Amendment 4 to the SEACAT 01 protocol. Amendment 4 is presented in this separate file on the website for clarity. 