<qa>  What is the maximum dose of methadone used in Arm 2 of this protocol?Risks to participants. Participants on methadone may experience side effects of sedation, constipation, or mild euphoria. The risks of overmedication will be reduced by gradually increasing the dose of methadone over the first week. The methadone dose used in Arm 2 of this protocol, 100 mg, is within the limits allowed by the FDA guidelines and within the dose range used in methadone clinics in Baltimore. For Arm 3 of the protocol, there is no ceiling methadone dose. Methadone doses will be adjusted by the MRP as clinically indicated based on participant feedback, withdrawal signssymptoms, reported cravings, and urine toxicology results. If a patient shows signs of intoxication, the MRP will reduce the methadone dose until evidence of intoxication has subsided. Methadone will be discontinued if a participant experiences severe side effects. Participants who are withdrawn from methadone will experience opiate withdrawal symptoms, but these symptoms will be minimized by the long detox period of 8 to 12 weeks. Other risks are the inconvenience of carrying and using the EDs, and possible embarrassment from providing urine samples under observation, and concern about the collection of GPS data. 