<qa>  What is the first and only ingenol mebutate product approved by the FDA inPicato ingenol mebutate gel is the first and only ingenol mebutate product approved by the FDA in 2012 for the topical treatment of AKs on the face and scalp 0.015 formulation and on the trunk and extremities 0.05 formulation. A generic ingenol mebutate gel, 0.05 has been developed for the topical treatment of clinically typical, visible, and discrete non-hyperkeratotic, non-hypertrophic AK lesions of the trunk or extremities. 