<qa>  What is the purpose of the single centre, open label, dose escalation study?This single centre, open label, dose escalation study is designed to assess safety including adverse events, vital signs, ECGs, and clinical laboratory tests, and pharmacokinetic pharmacodynamic parameters in healthy volunteers. Subjects will attend for 3 sessions: session 1 is a single intravenous IV infusion over a short time period to confirm the safety of a single dose of GSK2315698 over a wide dose range, sessions 2 and 3 will investigate IV infusion regimens over 24 hours induction phase followed by maintenance phase. The dosing regimen will be adjusted adaptively to optimise the induction and maintenance phases of the dosing regimen. amyloidosis. 