<qa>  What is the main study parameters used for evaluating the short term safety and tolerability?The main study parameters used for evaluating the short term safety and tolerability will be vital signs heart frequency, blood pressure, cardiac ischemia before and until 15 minutes after administration of the study drug and the need for intervention. Furthermore , biochemistry and haematology taken as part of standard clinical care will be assessed, and the occurrence of Serious Adverse Events SAEs until 7 days on the ICU or until discharge from the ICU, whichever occurs earlier. 