<qa>  What fraction of plasma will be purified from the plasma?At screening, plasma will be separated from patients venous blood 400ml aseptically and autologous immunoglobulin fraction will be purified from the plasma by chromatography using Protein A during the screening period. Patients will be randomized in a 1:1 ratio to receive weekly treatment with autologous immunoglobulin or placebo normal saline for 2 months will be administrated by intramuscular injection, once a week for 7 weeks total 8 injections. 