<qa>  What is the minimum of ULN?- Must have adequate renal and hepatic function documented by a serum creatinine 1.5 x the institutional upper limit of normal ULN, serum bilirubin 1.5 x ULN and liver enzymes AST, ALT, or alkaline phosphatase 2 x ULN 5 x ULN if hepatic metastasis within 21 days prior to registration. 