<qa>  What is the name of the study that aims to address the effects of stimulant therapy?The prevalence of overweight and obesity, insulin resistance, hyperglycemia, dyslipidemia and type 2 diabetes mellitus T2DM are increasing in children. Increased adiposity and related reductions in insulin sensitivity are major risk factors for the development of hyperglycemia, dyslipidemia, T2DM, and cardiovascular disease. Reductions in lifespan attributable to obesity impact younger individuals most measurably. Antipsychotic medications are extensively used in children, with certain agents producing greater increases in weight and adiposity than other commonly used drugs in this age group. Increased use of atypical antipsychotics in children has been stimulated by reported efficacy for behaviors such as aggression that can occur in a variety of disorders. However, no previous randomized clinical trial has sensitively quantified the metabolic effects of widely used atypical antipsychotics. This study would address clinically relevant questions concerning both the safety and efficacy of these agents in antipsychotic-naïve aggressive children with conduct disorder, with permitted co-morbidity for a variety of psychiatric conditions including attention deficit disorder, bipolar disorder, high functioning pervasive developmental disorder, autism and schizophrenia. The project aims to describe and compare the outcome of 12 weeks of prospective, randomized treatment with olanzapine, risperidone or aripiprazole on insulin action in skeletal muscle, liver and adipose tissue, insulin secretion, abdominal fat mass, total body and fat-free mass, resting metabolic rates, efficacy for symptoms of aggression and non-metabolic adverse events. Children aged 6-18 will be studied, exploring effects of stimulant therapy and age-related differences in vulnerability to treatment-induced adverse metabolic changes. Aims are addressed by measuring glucose and lipid kinetics with stable isotope tracers, area-under-the-curve for post-load insulin and c-peptide during frequently sampled oral glucose tolerance tests, body composition with dual energy x-ray absorptiometry and magnetic resonance imaging MRI, indirect calorimetry and standardized assessments of efficacy and adverse events. Treatment effects will primarily be analyzed using repeated measures analysis of covariance ANCOVA, controlling for baseline adiposity and other key risk variables. Relevant data are critically needed to target clinical therapy and basic research, identify medical risks, and guide regulatory decisions in this vulnerable population. 