<qa>  What was the first dose of the subjects in each cohort?In each cohort, the initial 2 subjects were 1 study drug recipient and 1 placebo recipient on Day 1 sentinel subjects. Subjects 3 to 5 and 6 to 8 were dosed after Day 7 a minimum of 24 hours apart between the subgroups. Each subject was dosed at least 1 hour apart in the same subgroup. If necessary, dosing of the rest of the subjects was delayed pending review of any significant safety issues that may have arisen during the post-dose period involving the first or second subgroups in that cohort. The subsequent cohort was dosed at least 3 weeks after the prior cohort. 