<qa>  What is the purpose of the investigation?Ethical considerations This investigation will be performed in accordance with the principles of the Helsinki Declaration, and all patients will receive both oral and written information before informed consent to participate is obtained. It will be the investigators job to inform all patients until they completely understand all aspects of participation. At any time being the patient will be able to cancel participation also without any explanation in this investigation. The patient will receive the best possible treatment in any circumstance. 