<qa>  What is the estimated glomerular filtration rate?This study explores the use of KBP-5074 in patients with advanced stages of Chronic Kidney Disease CKD including patients with severe renal impairment and those on hemodialysis HD and to assess the safety, tolerability, and pharmacokinetics PK of single doses of KBP-5074 in male and female patients with severe CKD defined as estimated glomerular filtration rate eGFR 15 mLmin1.73 m2 and 29 mLmin1.73 m2, based on the Modification of Diet in Renal Disease MDRD equation and a subset of patients requiring HD. 