<qa>  What is the current or history of any clinically significant cardiac abnormalitiesdysfunction- Current or history of any clinically significant cardiac abnormalitiesdysfunction, including but not limited to: angina, congestive heart failure, myocardial infarction, pulmonary hypertension, complex congenital heart disease, cardiomyopathy, significant arrhythmia, uncontrolled hypertension, a history of use of antianginal or anti-arrythmic agents for cardiac conditions, prolonged ECG QTc interval 470 ms for males or 480 ms for females by either the Bazett or Fridericia formula at the screening visit, personal or family history of Torsade de pointes. 