<qa>  How many patients will participate in the study?In this study a total number of 80 patients with diagnosed migraine according to the criteria of the International Headache Society HIS Cephalalgia 1998; 8 Suppl7 :1-98 will participate. Patients who will be enrolled should be either male or female over 18 years of age, they should satisfy the migraine prophylactic medication criteria, and will agree to sign the written informed consent for the anonymous and confidential use of their medical data with their participation in the study. 