<qa>  What is the name of the prior malignant tumour in past 5 years?Pregnant or nursing woman Prior administration of systemic immunotherapy, chemotherapy exception: 5-FU as adjuvant treatment 12 months following conclusion of treatment Evidence of allergic reaction to any of the treatment components Clinically relevant myocardial disease or history of myocardial infarction in the past 12 months Documented or suspected cerebral andor leptomeningeal metastases. Prior malignant tumour in past 5 years, except history of basal cell skin carcinoma or pre-invasive cervical carcinoma. 