<qa>  What is the randomized, open-label, multicenter study?OUTLINE: This is a randomized, open-label, multicenter study. Patients are stratified according to performance status 0 vs 1 vs 2, metastatic disease M0 vs M1, prior pelvic radiotherapy for pelvic recurrence yes vs no, and participating center. Patients are randomized to 1 of 2 treatment arms. 