<qa>  What must be resolved before the first dose of study drugs?4. Subjects must have completed chemotherapy, targeted therapy, investigational therapy, other immunotherapy, prior radiotherapy, or major surgery requiring general anesthesia at least 28 days before administration of the first dose of study drugs. Subjects undergoing minor surgical procedures and biopsies that do not require general anesthesia may begin receiving study therapy if sufficiently recovered as determined by the treating investigator. Clinically significant toxicity experienced during any prior therapy must be resolved or stabilized before the first dose of study drugs. 