<qa>  What is the ability to sustain effective therapy over time?Participants are randomly assigned to receive risperidone Risperdal, olanzapine Zyprexa, or molindone Moban for 8 weeks. After 112005, no additional patients will be assigned to olanzapine treatment. Patients with significant improvement and without side effects continue maintenance therapy for another 44 weeks. Participants who show significant negative symptoms after 8 weeks may be started on a mood stabilizer or antidepressant. Weight gain, metabolic changes, neurocognition, functional outcome, psychotic symptoms, extrapyramidal side effects, and the ability to sustain effective therapy over time are assessed. 