<qa>  What is the study hypothesis that methotrexate and SMP-114 are more effTo compare the efficacy of SMP-114 120 and 240 mgd versus placebo in terms of the percentage of patients meeting the American College of Rheumatology criteria for 20 improvement in RA ACR20 at week 24. The study hypothesis would be to demonstrate that the use of methotrexate and SMP-114 is more efficacious than Methotrexate alone. 