<qa>  What is the primary or secondary malignant tumor of the central nervous system?1. Patients must have: a Histologic or cytologic confirmation of adenocarcinoma of the prostate; or b A histologically confirmed, treatment-naïve, locally advanced breast cancer that express either estrogen receptor ER or progesterone receptor PR and are negative for ErbB2 by Immunohistochemistry IHC andor fluorescence in situ hybridization FISH gene amplification; or c Suspected supratentorial malignant primary or secondary malignant tumor of the central nervous system CNS. 