<qa>  What is the effect of VEGF-inhibition by this drug on circulating levelsIV. Determine the effect of vascular endothelial growth factor VEGF-inhibition by this drug on circulating levels of VEGF and related cytokines that also contribute to HCC pathogenesis including bFGF, TGF-alpha, and IGF-II and on potential alterations of these levels on prognostic variables in these patients. 