<qa>  What is the second measure?- NOTE: rising PSA, defined as at least two consecutive rises in PSA to be documented over a reference value measure 1; the first rising PSA measure 2 should be taken at least 7 days after the reference value; a third confirmatory PSA measure 2nd beyond the reference level should be greater than the second measure, and it must be obtained at least 7 days after the 2nd measure; if this is not the case, a fourth PSA is required to be taken and be greater than the second measure; measurable disease is not required 