<qa>  What is the best option for patients with unresectable mCRC who receive bestMetastatic colorectal cancers are generally not curable. Median overall survival for patients with unresectable mCRC who receive best supportive care BSC is five to six months. Palliative treatment with systemic chemotherapy is the best option prolonging survival and maintaining quality of life. Patients who are exposed to all active drugs can sometimes extend survival past two years. 