<qa>  What is the goal of this investigation?The aim of this investigation is to identify whether CTGF may play a role in the pathogenesis of CAN in humans. Our long-term objective is to determine whether CTGF and other cytokine mediators may be novel targets for the therapy of CAN. Our goals are to: 1. Determine the level of CTGF expressed in the urine and serum CTGF of recipients of kidney transplants; 2. Identify whether urinary or serum CTGF might be a marker of CAN and be utilized as a predictor for those at risk to develop the disease; 3. Identify other molecular messages and proteins that may identify the development of CAN, as potential future targets of treatment. 