<qa>  What type of disease is deteriorated due to age, uncontrolled epilepsy orPatients or subjects with severe uncontrolled medical problems e.g. cardiovascular disease, severe rheumatoid arthritis, active joint deformity of arthritic origin, active cancer or renal disease, any kind of end-stage pulmonary or cardiovascular disease, or a deteriorated condition due to age, uncontrolled epilepsy or others. 