<qa>  What is a pre-menopausal female?- A female subject is eligible to participate if she is of non-childbearing potential defined as pre-menopausal females with a documented tubal ligation or hysterectomy; or postmenopausal defined as 12 months of spontaneous amenorrhea in questionable cases a blood sample with simultaneous follicle stimulating hormone FSH 40 MlUml and estradiol 40 pgml 147 pmolL is confirmatory. As a precaution a pregnancy test will be conducted prior to dosing; a positive test will lead to exclusion. 