<qa>  What is a high bleeding risk defined as?- No high bleeding risk. A high bleeding risk is defined as a platelet count below 40 x 109L or APTT of more than 60 seconds or a PT-INR of more than 2.0 or a recent major bleeding or significant active bleeding i.e. requirement for more than two units of packed red blood cells as a transfusion within 24 hours of initiation of CVVH. 