<qa>  What is the most likely to have a less favorable response?Currently PEG-Interferon alfa-2b plus Ribavirin results in a sustained response in 54-61 of patients with Hepatitis C. Those with genotype 1and 4 and high viral loads are the most likely to have a less favorable response. The administration of induction dose interferon in combination with Ribavirin may yield an improved sustained response rate in these more difficult to treat patients with chronic Hepatitis C. 