<qa>  What is the goal of this work?The goal of this work is to critically test the hypothesis that there exists a different profile of bile acids BAs in patient with type 2 diabetes mellitus T2DM compared with normal controls. Through confirmation of different profile of BAs in T2DM, investigator will suggest modulation of specific bile acids as a new possible treatment target in patients with T2DM. Investigator also expect the specific BAs signature will be used to screen T2DM before hyperglycemia. 