<qa>  What is the total duration of study subject participation?Subjects will return to the study center the day they are screened and as close to the same day of the week as practical during Weeks 1 baseline, 2, 3, 4, 5, 6, 7, 8 end of treatment and 10 post-treatment for examinations and specimen collection, as well as evaluation of reactions to study treatment. At the end of the 8-week drug administration period, patients will again be admitted to an in-patient facility for 72 hours. As before, patients will have an initial night to acclimate to the facility, followed by a 24-hour measurement of cortisol secretion in blood and urine. In the morning, following and ending the 24 hour basal cortisol secretion, patients in the four successive groups A, B, C, and D, will receive their last dose of medication. They will also give their last blood and urine samples over the next 24 hours for additional safety sample collection. The total duration of study subject participation will be 11 weeks. 