<qa>  How many hemodialysis patients will be enrolled in the study?Seven hundred and four hemodialysis patients treated in Ege University Hospital Dialysis Unit and eight FMC Clinics will be enrolled into the study 3-year follow-up; percentage of yearly expected end-point 10;expected event-free survival rate for control group during three year is 72.9,a bilateral alpha risk equal to 5; an 90 power to detect an increase of 15 in event-free survival at the end of 3-year follow-up in favor of the each intervention group. Annual drop-out rate is estimated as 15-20. 