<qa>  What is the standard dose of pemetrexed for systemic administration?The standard dose of pemetrexed for systemic administration is 500 mgm2. However, because pemetrexed has not been previously studied for direct administration into the chest, the initial cohorts will receive a slightly lower dose to ensure this method of administering pemetrexed is safe. Once safety has been established at lower doses, the investigators will feel confident that pemetrexed intrathoracic doses that are slightly higher than the standard systemic dose 500 mgm2 can be given safely. In animal models, these higher doses resulted in a systemic concentration of pemetrexed which is correlated with systemic toxicities that is potentially lower after intracavitary infusion than after systemic administration 2. These higher doses may result in superior long-term clinical outcomes. 