<qa>  What is a sign of severe clinical infection?4. Has an ulcer that meets any of the following criteria: a Shows signs of severe clinical infection, defined as pus oozing from the ulcer site; b Is positive for β-hemolytic streptococci upon culture; c Has 50 slough, significant necrotic tissue, bone, tendon, or capsule exposure; d Is highly exuding i.e., requires daily change of dressing 