<qa>  What is the CNS symptoms grade 2 or higher for patients with GBM?Any CNS deficits. For patients with GBM, CNS symptoms grade 2 or greater. Subjects with significant or uncontrolled cardiovascular disease eg, uncontrolled hypertension, peripheral vascular disease, congestive heart failure, cardiac arrhythmia, or acute coronary syndrome within 6 months of starting study treatment or heart attack within 12 months of starting study treatment. 