<qa>  What is a randomized, double-blind, placebo controlled trial of venlaThe study evaluates the benefits of a promising antidepressant medication for the treatment of persons with traumatic brain injury TBI and major depressive disorder MDD. The study is a randomized, double-blind, placebo-controlled trial of venlafaxine a serotonin and norepinephrine reuptake inhibitor, also known as Effexor. Venlafaxine has been well established in the treatment of MDD in healthy individuals and is a recommended depression treatment agent for persons with TBI. By using a rigorous scientific methodology, this study will be an important first step in advancing the treatment of depression in this population beyond general impressions to proven treatments. 