<qa>  What is the effect of lapatinib on cardiac repolarization?This study will estimate the effect of lapatinib on cardiac repolarization QTc interval duration in subjects with advanced solid tumors. The study treatment period will occur over five days and an End of Study visit will be conducted on Day 8 or no later than 3 days beyond Day 8. Subjects will receive placebo that mimics lapatinib for 2 days as three separate doses given 12 hours apart 8 tabletsdose and lapatinib 2000mg for 2 days as three separate doses given 12 hours apart 8 tabletsdose. Subjects will not know when they are receiving placebo vs. lapatinib. Digital 12-lead ECG recordings will be extracted from continuous ECG recordings obtained via a Holter monitor to measure QTc interval duration. Triplicate ECG measurements of QTc interval will be taken at pre-specified times at Day 1 Baseline and pre-dose and up to 24 hours after the third dose of placebo or lapatinib on Study Days 2 and 4. Pharmacokinetic sampling will occur immediately following each pre-specified QTc measurement in subjects dosed with placebo or lapatinib. Subjects who complete participation in this study, if they are eligible, will be offered the option to continue treatment with lapatinib, either alone or in combination with other oncology drugs in pre-selected anticancer regimens, in a continuation protocol, EGF111767. 