<qa>  What is the reason for comparing the effects of the two doses of protein?Since we do not know whether different doses of the NY-ESO-1 protein may result in varying degrees of immune stimulation, we will be randomizing that is, at the flip of a coin or, in other words, by chance you may receive either the lower dose of NY-ESO-1 protein 100 μg or the higher dose 400 μg. There is a 50:50 chance that you will receive the lower versus the higher dose. At this time we have no way of knowing whether there will be any real difference in the effects between these doses. In either case you will be receiving the NY-ESO-1 protein. In all studies to date, only the 100 μg dose has been used. There is no reason to think that the higher dose will be toxic, nor is there any reason at this time to think that the higher dose will be more effective at the immunological level, although it may be, which is the reason for comparing the effects of these two doses of protein. 