<qa>  What is defined as any disease that would put the safety of the subject at risk?- Other DiseasesAbnormalities: Subjects with historical or current evidence of clinically significant cardiovascular, neurological, psychiatric, renal, hepatic, immunological, endocrine including uncontrolled diabetes or thyroid disease or haematological abnormalities that are uncontrolled andor a previous history of cancer in remission for 5 years prior to Visit 1 localized carcinoma of the skin that has been resected for cure is not exclusionary. Significant is defined as any disease that, in the opinion of the investigator, would put the safety of the subject at risk through participation, or which would affect the efficacy or safety analysis if the diseasecondition exacerbated during the study. Any physical or mental abnormality which would affect the patient carrying out exercise tests including peripheral vascular disease should be excluded at the investigators discretion. 