<qa>  What is allowed for residual localized 1.4 For patients with PD, change to second-1.3 For patients with maximal response as PR or SD, change to second-line chemotherapy. The regimens for second-line chemotherapy are at the discretion of the investigators. Local radiotherapy is allowed for residual localized 1.4 For patients with PD, change to second-line chemotherapy. The regimens of the latter are at the discretion of the investigators. 