<qa>  What is the clinical trial of upfront bone marrow transplantation?This is a clinical trial of upfront bone marrow transplantation for patients with SAA who do not have a fully human leukocyte antigen HLA matched donor. The trial uses a conditioning regimen which has been successful in the refractory and relapsed setting to maximize engraftment and post transplant therapy to minimize graft versus host disease GVHD. This would be used here in patients who have not yet undergone immunosuppressive therapy for their SAA or are thought to be unlikely to respond to immunosuppressive therapy for SAA. 