<qa>  What is the IC?Biopsies: After having signed the IC and having evaluated that the patient is potentially a candidate for the clinical trial, the patient will be biopsied under echographic guide. Three needle cores will be obtained to a make the final diagnosis, b measure PRAPRB isoform ratio by western blot WB, c measure ER and PR by immunohistochemistry IHC and store the paraffin block for biomarker staining and, d perform tumor transcriptome. Biopsy core will be flash frozen at -80 C for molecular studies and the others fixed in 10 buffered formaldehyde for diagnosis determination and PR IHC following routine hospital guidelines. 