<qa>  What was the effect of Zoledronic Acid given once as an intravenous infusionThe core study looked at the effect of Zoledronic Acid given once as an intravenous i.v. infusion compared to 60 days of oral Risedronate in patients with Pagets disease of bone. The effect was demonstrated in the reduction of serum alkaline phosphatase SAP. The extended observation period included participants of the core study who responded to treatment. 