<qa>  What is the major symptom of gastrointestinal disorder with diarrhea?- Significant gastrointestinal disorder with diarrhea as a major symptom example Crohns disease, ulcerative colitis or Grade 2 diarrhea of any etiology at baseline. Active hepatobiliary disease with the exception of patients with Gilberts syndrome, asymptomatic gallstones, liver metastases, or stable chronic liver disease as determined by investigators assessment. 