<qa>  What is the most important factor associated with low CD4CD8 ratio?Anti-HIV drugs cut down the number of serious infections that people with HIV get. However, some subjects taking anti-HIV drugs do not achieve adequate cluster of differentiation 4 CD4 recovery and decrease in elevated cluster of differentiation 8 CD8 cells. Such patients with a low CD4CD8 ratio remain at risk for developing acquired immune deficiency syndrome AIDS and non-AIDS-related complications. Two of the most important factors associated with low CD4CD8 ratio include: the persistence of HIV on ART and inflammation. 