<qa>  What is the centrally-acting compound that is clinically appreciable?- Subject is receiving concomitant therapy with: centrally-acting anorectic agents; monoamine oxidase inhibitors; any centrally-acting compound with clinically appreciable amount of serotonin agonist or antagonist properties, including serotonin reuptake inhibition; atomoxetine, or other centrally-acting noradrenergic agonist; cyproheptadine, andor cytochrome P450 CYP 2D63A42B6 inhibitorssubstrates. 