<qa>  What is the effect side of the brain?The clinical daily routine indicates that slowing the rate of administration of propofol can lead to a reduction of up to 50 in the dose of propofol required to achieve the onset of a clinical endpoint of anesthesia i.e. loss of consciousness when titrating to effect. Therefore, it has been concluded that a slow injection requires a smaller dose of propofol as the graded effect is weakened by fast injection. This conclusion contradicts pharmacologic considerations, that a fast injection would lead to a higher peak concentration and in consequence, to a higher peak effect at the effect side, the brain. 