<qa>  What is the AST andor ALT?1. Clinically-significant inadequate hematological, hepatic and renal function, defined as: Neutrophil count 1.5 x 10 9L and platelet count 100 x 109L; bilirubin 1.5 x upper limit of normal ULN; aspartate transaminase AST andor alanine aminotransferase ALT 2.5 x ULN or 5 x ULN if patient has documented liver metastases; and serum creatinine 1.5 x ULN 