<qa>  What is the dose of IgGAM conjugate?Demographic and clinical data will be collected by the investigator age, weight, sex, acute and chronic diseases present at inclusion, GCS, APACHE II, SAPS II, arterial blood gases, SOFA score, lab data such as Hb, WBC, hepatic and renal function, blood sugar, Procalcitonin Patients will be randomized into two groups treaties and controls: patients in Group of the treaties will be submitted to infusion of IgGAM conjugate Pentaglobin at dosage of 250 mgkg IV 5 mLkg per day rate of 0.4 mLkgh, for 72 hours. The controls will receive equal amount of physiological NaCl solution 0.9 as placebo. Neither the patient nor the staff nurses and MD will be aware of the group and of the treatment applied double blind trial. IgGAM solutions or NaCl 0.9 are provided by the hospital pharmacy in similar bags. 