<qa>  What is the replication-defective recombinant adenoviral vectorAd.hIFN-β BG00001 is a replication-defective recombinant adenoviral vector containing the human interferon-beta hIFN-β gene. This Phase I study is designed to evaluate the safety and maximum tolerated dose MTD of two doses of intrapleural IP Ad.hIFN-β in subjects with pleural malignancies either metastatic or pleural mesothelioma. 