<qa>  What is a history of therapy with split dose oral MTX?4. Received uninterrupted treatment with weekly MTX begun 3 months prior to enrollment, at a stable dose of 15 mg per week for at least 4 weeks prior to enrollment. A history of therapy with split dose oral MTX or parenteral MTX is acceptable only if the weekly MTX dose was always 20 mgweek during the 3 months prior to enrollment. 