<qa>  What is the goal of this study?The objectives of this study are 1 to compare Artacent to standard of care SOC in the treatment of non-healing lower extremity ulcers and 2 to evaluate the impact of treatment on patient quality of life. Health economic outcomes will also be collected. The proportion of patients receiving Artacent who have wound closure with 12 weeks will be compared to those patients receiving SOC only will be compared. A comparison of time to wound closure will also be compared between the two populations. 