<qa>  What is the preponderance of affective disorder in women?A recent preliminary trial by Bebchuk et al, 2000, demonstrated that adjunctive tamoxifen improved in manic symptoms in seven patients. A limitation of their trial was that they failed to standardise the other treatment agents used, which included lithium, antidepressants, anxiolytic and anti-psychotic medications. Mania in women is also noted to have cyclic variations, which is poorly documented and largely anecdotal. This needs further study, and since there is a preponderance of affective disorder in women, we propose conducting a study in women with active symptoms of mania. 