<qa>  What is the lowest dose of IL-2?In our current study, the lowest dose of IL-2 1 x 106 IU is similar to the doses used by Yee et al. in their adoptive I cell therapy. This dose has been shown to expand and maintain CTLs in both preclinical and clinical models. The highest dose 11 x 106 IU was chosen based on the expected toxicities from higher doses of IL-2 and our experience with this dose as a single agent in RCC. 