<qa>  What is the critical overlap of circuitry implicated in negative symptoms?Overlap of Reward Circuitry and Areas Implicated in Negative Symptoms As indicated above, dopaminergic hypofunction in the PFC is strongly implicated in the pathophysiology of negative symptoms. The presentation of reward or stimuli that predict reward stimulates the phasic activation of dopaminergic neurons in the midbrain Shultz 2000 that innervate the PFC. Hence there is a critical overlap of circuitry implicated in negative symptoms and circuitry that subserves reward processing. This overlap supports the use of reward paradigms to explore the functional integrity of mesocortical DA inputs and PFC function. 