<qa>  What is the effect of antiretroviral therapy on the naive T-Part 2 seeks to answer whether infection of naïve T-cells is established early in infection and what the effect of antiretroviral therapy is on this subset of T-cells. We will initially examine the relative proportion of CD31 recent thymic emigrants and CD31- naive CD4 T-cells in infected acute n15 and chronic n15 infection and uninfected n15 individuals compared with healthy controls. We will then prospectively test individuals prior to and at 3, 6, 12, 18 and 24 months following intiation of HAART Highly Active Antiretroviral Therapy in individuals with acute n10 and chronic n10 HIV infection. Immunophenotyping will detemine the proportion of naïve T-cells that are CD31 and those that are CD31-. Naïve and memory T-cell subsets will again be purified and total and integrated HIV DNA will be quantified using real-time PCR. 