<qa>  How many volunteers will be randomly assigned to four groups?A total of 32 volunteers will be randomly assigned to four groups n8 and subjected to a standard controlled human malaria infection CHMI delivered by five Pf-infected mosquitoes 3D7 clone. Treatment is subsequently initiated to induce gametocytaemia treatment 1, DT1 and to clear pathogenic asexual parasites whilst leaving gametocytes unaffected treatment 2, DT2. At the end of the study, treatment of all parasite stages is provided following national treatment guidelines end treatment, ET. 