<qa>  What is the definition of a state of adequate sedation?AQUAVAN. Injection and midazolam HCl will be administered to induce a state of adequate sedation, defined as a Modified Observers Assessment of AlertnessSedation OAAS score of 4 or less. Supplemental doses will be administered to increase depth or duration of sedation. Supplemental doses will not be administered if the Modified OAAS score is 2 or less or if there is no purposeful response to stimulation. The depth of sedation will be measured by the Modified OAAS scale, a validated measure. Patient and Investigator assessments will be used to confirm the depth of sedation provided met the goals of sedation, reduction of anxiety and reduced awareness. 