<qa>  What is the name of the microbiome interplay between the bladder and vagina?While almost nothing is known about urinaryvaginal microbiome interplay, even less is known about immune response modulation in the bladder and vagina. However, estrogen reduces the subsequent urinary tract infection UTI rate in hypoestrogenic women affected by recurrent UTI, and estrogen induces urothelial antimicrobial peptide AMP expression. Since AMPs exhibit microbicidal activity, stimulate inflammation, and facilitate epithelial barrier homeostasis, estrogen may work through AMPs as mediators to optimize microbial equilibrium. 