<qa>  What is the name of the active central nervous metastases?4. Known active central nervous metastases. Subjects with previously treated brain metastases may participate provided they are stable without evidence of progression by imaging for at least four weeks prior to the first dose of trial treatment and any neurologic symptoms have returned to baseline, have no evidence of new or enlarging brain metastases, and are not using steroids 10 mgday pf prednisone or equivalent 