<qa>  What is the rate of active rheumatoid arthritis according to American College- Active rheumatoid arthritis according to the American College of Rheumatology of at least six months duration with six or more swollen and six or more tender joints of 28 joints and Erythrocyte Sedimentation Rate ESR 22 mmh andor C-Reactive Protein CRP 10 mgL 1 mgdL. 