<qa>  What is the COP-R regimen?REDUCTION THERAPY: Patients receive the COP-R regimen comprising cyclophosphamide IV over 15 minutes, vincristine IV, and methotrexate and hydrocortisone intrathecally IT on day 0; rasburicase IV over 30 minutes every 12 hours on days 0 and 1 and then once daily on days 2-4 patients exhibiting hyperuricemia and clinical suspicion of B-cell non-Hodgkins lymphoma or B-cell acute lymphocytic leukemia also receive rasburicase on days -3, -2, and -1; leucovorin calcium IV or orally every 12 hours on days 1 and 3; and prednisone PRED or methylprednisolone MePRDL IV or orally on days 0-6. Patients too critical to proceed may receive another course of reduction therapy. 