<qa>  What is a history of major upper gastrointestinal disease?- A history of recent within one year of screening major upper gastrointestinal GI disease above the jejunum, including, but not limited to, peptic ulcer, esophageal disease or active GI bleeding, or ever had surgery of the upper GI tract other than pyloroplasty. A history of abnormalities of the esophagus which delay esophageal emptying, such as stricture or achalasia 