<qa>  What is the primary analysis of continuous data?Mean, median, standard deviation, and interquartile ranges will be determined for all continuous data. The primary analyses will include all randomized subjects based on intent to treat regardless of whether they completed the study. Additional analyses will be conducted based on subjects completing the protocol i.e. those withdrawn from the study prior to completing the protocol or receiving open-label ketamine will be excluded and those completing treatment. Statistical analysis of continuous data between groups will use the student T test or the Mann-Whitney U for parametric and nonparametric data, respectively. Statistical analyses of continuous data within a study group will use the paired student T test or the Wilcoxan Rank test for parametric and nonparametric data, respectively. Statistical analysis of proportions will use the Chi-square test or Fishers Exact test for parametric and nonparametric data, respectively, with appropriate corrections for small sample size. Pearson product or Spearman Rank Order will be used for correlation analyses of IL-1β or IL-6 with the results of the psychometric scoring tools. The study is designed to investigate the primary hypothesis and the related specific aims. All secondary hypotheses are exploratory to investigate consistency of data and analyses will be interpreted cautiously. 