<qa>  What is the history of serious systemic disease?- History of serious systemic disease, including active infection, uncontrolled hypertension diastolic blood pressure 100 mmHg on two consecutive occasions, unstable angina, congestive heart failure, or myocardial infarction within 6 months prior to Day 1, or unstable symptomatic arrhythmia requiring medication subjects with chronic atrial arrhythmia, i.e., atrial fibrillation, paroxysmal supraventricular tachycardia, or controlled hypertension are eligible 