<qa>  What is the most common cause of posttransplant morbidity and mortality?Viral infections are a significant cause of posttransplant morbidity and mortality and two of the herpes viruses have the greatest impact: Epstein-Barr virus EBV and Cytomegalovirus CMV. CMV disease can manifest posttransplant as fever, leukopenia, or mild to severe organ involvement including pneumonitis, hepatitis, pancreatitis, colitis, meningoencephalitis, and rarely myocarditis. EBV can present posttransplant as infectious mononucleosis syndrome, hepatitis and, in the worse case scenario, a potentially fatal lymphoproliferative disorder called Post-Transplant Lymphoproliferative Disease PTLD. Moreover, subclinical CMV andor EBV viremia have been associated with deterioration in kidney function in kidney transplant recipients. Thus, the potential negative impact of these viruses on the lives of transplant recipients is profound and, unfortunately, the complications of these post-transplant viral infections are common and occur despite standard antiviral prophylaxis in the first year posttransplant. 