<qa>  What should participants undergo a 24-hour urine collection?12. Participants with clinically significant proteinuria. Urine protein should be screened by urinalysis. Participants discovered to have a urine protein: serum creatinine ratio greater than or equal to 1 should undergo a 24-hour urine collection, which must be an adequate collection and must demonstrate 1000 mg protein24 hr to allow participation in the study. 