<qa>  What is the upper limit of normal liver function?5. Adequate liver function as evidenced by bilirubin less than or equal to 1.5 times the upper limit of normal ULN and alkaline phosphatase AP, alanine aminotransferase ALT, and aspartate aminotransferase AST less than or equal to 3 x ULN in the case of liver metastases less than or equal to 5 x ULN. In case AP is greater than 3 x ULN in absence of liver metastases or greater than 5 x ULN in presence of liver metastases AND subject also is known to have bone metastases, the liver specific AP must be separated from the total and used to assess the liver function instead of the total AP. 