<qa>  What is the tube placed into a large vein that is used to administer medications?Patients will be enrolled in the study after all study specific-entry criteria are met and informed consent is obtained. Patients will be required to attend regular clinic visits to receive study medication and have their status monitored. Patients will also be required to have radiologic tumor assessments performed at multiple times throughout the study. A detailed explanation can be provided by the study physician Investigator conducting this study. Trabectedin 580 mcgm2 once weekly for 3 consecutive weeks Treatment A or 1,300 mcgm2 once every 21 days Treatment B will be given to patients as a 3-hour intravenous i.v. infusion via a central venous catheter which is a tube placed into a large vein that is used to administer medications. All patients will be given dexamethasone 10 mg i.v. 30 minutes before each trabectedin infusion. Patients may receive multiple cycles of trabectedin in the absence of disease progression. 