<qa>  What is the most likely to be generated in minimum disease states?There are data on the use of tumor vaccines in advanced PC. Gjerertsen et al. used a K Ras peptide and GM-CSF in 48 patients with advanced PC. 50 of patients showed a peptide specific CTL response Gjertsen, Buanes et al. 2001. Those that had an immune response had an increased overall survival, The data from phase I and II clinical trials was based on heavily pretreated patients with metastatic disease. The majority of clinical responses have been disease stabilization. The data in B cell lymphoma vaccines suggests that immune responses are more likely to be generated in minimum disease states Bendandi, Gocke et al. 1999. 