<qa>  What is the potential importance of Proposal for Treatment Indications of AripPotential Importance of Proposal for Treatment Indications of Aripiprazole The severe impairment of motivated behavior in patients with deficit syndrome schizophrenia is strongly suggestive of an abnormality in the neural circuits that mediate reward processing and the translation of reward salience to motivated behavior. To date there are no published fMRI studies of the functioning of reward circuits in subjects with deficit syndrome schizophrenia. We hypothesize that negative symptom schizophrenics will exhibit impaired fMRI estimated activation of reward circuitry compared to normal controls, and that aripiprazole treatment will normalize functioning of this circuitry. 