<qa>  What is the cause of pulmonary fibrosis?We will investigate genetic, molecular, cellular, whole animal models, and human specimens from patients with fibrotic lung disease to test our prediction: The pathogenesis of pulmonary fibrosis lung scarring is due to multiple hits that causes an inbalance of certain mediators proteins that are responsible for abnormal blood vessel formation, scar tissue formation with and without inflammation inside the lungs and impaired immunity of the patient. Each of the 3 projects in this proposal have a direct link to other projects and clinical core. The SCOR clinical core will identify and enroll patients with Interstitial Lung diseases ILD, including IPF. The clinical core will collect clinical data, as well as obtain fluids from lung washings and human lung tissue specimens. Each project will use human specimens as indicated in each of their specific aims to correlate their findings with response to therapy. 