<qa>  What is the classification of Toxicity according to?Toxicity will be graded according to National Cancer Institute Common Terminology Criteria for Adverse Events CTCAE v4.02. Assessments of the antitumor activity of the combination will be performed at the end of Cycle 2 and every 2 cycles thereafter using standard techniques such as computerized tomography CT or magnetic resonance imaging MRI for patients with measurable disease. Response will be evaluated using Response Evaluation Criteria in Solid Tumors RECIST v1.1. Patients who experience no unacceptable toxicity or disease progression, may receive additional 28-day cycles for up to 1 year. 