<qa>  What is the best present combination chemotherapy, radiotherapy, and surgery?New treatment strategies are needed to improve the clinical outcome in breast cancer patients at high risk of recurrence. Even with the best present combination chemotherapy, radiotherapy, and surgery, disease recurrence and death is at least 60 in this population. Thus, new strategies are needed to improve survival. Recent advances that may improve clinical outcome include the use of taxoids paclitaxel and docetaxel, a new class of cytotoxic agents, with reported higher response rates than standard anthracycline-based chemotherapy. 