<qa>  What is the name of the group that will receive PO BID?This study is a randomized, placebo-controlled, single blind clinical trial. Seventy patients with ESRD on chronic HD and a functioning AVF will be recruited. The following data will be documented on each patient: 1-Agegenderracebody weightcause of ESRD 2-Vintage of HD 3-Time since access was placed 4-Type and place of access and blood flow rate of access 5-History of prior access problems 6-Comorbid conditions Hypertension, coronary artery disease, Diabetes Mellitus, Bleeding problems, peripheral vascular disease. 7-Current medications Coumadin, Erythropoiesis stimulating agents, heparin, other antiplatelets, digoxin, statins. Patients will be randomized into two groups to receive: Group 1: Ticagrelor 90 mg PO BID Group 2: Placebo drug PO BID. 