<qa>  What is the name of the significant renal, hepatic, neurologic, cardiovascular,- History or presence of significant renal, hepatic, neurologic, cardiovascular, hematologic, metabolic, cerebrovascular, respiratory, gastrointestinal, or other significant medical condition, including autoimmune or collagen vascular disorders aside from organ-specific autoimmune disease limited to the thyroid that in the investigators opinion could interfere with the study or require medical treatment that would interfere with the study 