<qa>  What is the aim of this study?Recently, a special emphasis has recently been directed to the potential role of vitamin D and some regulatory peptides e.g. adipokines and follistatin and their associated metabolic roles and genetic factors in the development of PCOS and its related co-morbidities. The aim of this study is to compare the effect of vitamin D supplementation therapy and Metformin therapy on plasma concentrations of adipokines ghrelin, resistin and adiponectin, follistatin and activins in participants diagnosed with PCOS. 