<qa>  What is the total bilirubin count?Neutrophil count 1.5 x 109l , platelets 100 X 109l serum creatinine 1.5 x ULN. Total bilirubin count 2 x ULN Alkaline Phosphatase 2.5 x ULN 5 x ULN if there are hepatic metastases Aspartate aminotransferase ASTSGOT and alanine aminotransferase ALTSGPT 2.5 x ULN 5 x ULN if there are hepatic metastases, 10 x ULN if there are bone metastases Creatinine clearance 30 mlmin Surgery within 4 weeks prior to enrollment in the study. Any investigational drug during the 4 weeks prior to enrolment. Uncontrolled active infection Any medical or psychological disorder which, in the opinion of the investigator, does not allow the patient to conclude the study or sign the informed consent 