<qa>  What is the name of the neuromediator that is characterized by a cholineBesides a non-specific serotoninergic dysfunction, no significant anomalies related to particular neuromediators have apparently been found as opposed to AD, which is characterized by a cholinergic deficit. In 1998, the discovery of mutations in the Tau gene in certain kindreds showing a dominant autosomal transmission of FTD, oriented research efforts toward the tau protein and provided new perspectives. Many studies have suggested the role of excitotoxicity. Abnormal aggregation of the tau protein has been observed in the brains of a majority of FTD patients familial and sporadic form. Excitotoxicity may be responsible for promoting this abnormal aggregation through modification of the expression and phosphorylation state of the tau protein. The hypothesis of this study is that an anti-excitotoxic neuroprotective treatment may slow the pathogenic process and therefore be an effective treatment for this pathology. 