<qa>  What is the pharmacokinetics of the three safe probe drugs?To evaluate the drug interaction potential of cranberry, single doses of the three safe probe drugs alprazolam, dextromethorphan, and caffeine will be administered before and after a 14-day treatment period with cranberry powder. Changes in the pharmacokinetics of these probe drugs will indicate the degree of enzyme inhibition or induction. The key pharmacokinetic parameters for four major CB flavonoids will be estimated by following the plasma concentration versus time course of absorbed flavonoids and their excretion in urine. The area under the plasma concentration versus time curve AUC, oral clearance Clo, terminal elimination half-life T12 and renal clearance Clren will be determined for: epicatechin, quercetin total glycosides, procyanidin A2, and cyanidin-3-galactoside. 