<qa>  What is the primary efficacy endpoint of cyclophosphamide?Subjects will be followed up for 24 weeks after the end of chemotherapy. In this study, the primary efficacy endpoints are maximum tolerated dose MTD of cyclophosphamide in combination treatment with bortezomib and fludarabine, complete response rate CR CRu, overall response rate ORR. Main indicators will be evaluated every 2 cycles in the treatment period and every 12 weeks in follow-up period. 