<qa>  What is the effect of thalidomide treatment on HIV replication?In patients with chronic HIV infection, HIV replication and abnormalities in immune function persist following treatment with highly active antiretroviral therapy HAART. Specifically, costimulatory T cell interactions are impaired. The immune modulatory drug thalidomide was recently found to costimulate T cells. Pharmacologic T cell costimulation may compensate for the T cell deficiencies in people with HIV disease and improve immune function. This study will test whether thalidomide treatment enhances HIV and cytomegalovirus CMV-specific immunity in patients with HIV and CMV, and will evaluate the effect of thalidomide on HIV replication. 