<qa>  What can be seen as a potential indicator of the efficacy of MS management?With loss of mobility in multiple sclerosis MS comes an increase in amount and types of caregiver assistance, with a concomitant increase in burden for the caregiver. In fact, effect on caregiver burden can be seen as a potential indicator of the efficacy of MS management, suggesting that the caregiver is an appropriate and independent target for MS therapeutic strategies. 