<qa>  What is the second most common primary hepatic malignancy?Cholangiocarcinoma CCA is an epithelial cancer originating from the bile ducts with features of cholangiocyte differentiation. CCA is the second most common primary hepatic malignancy, and epidemiologic studies suggest its incidence is increasing in Western countries. Hepatobiliary malignancies account for 13 of the 7.6 million annual cancer-related deaths worldwide and CCA accounts for approximately 20 of the deaths from hepatobiliary malignancies Kubicka and Manns 2000; Kubicka 2004; Blechacz and Gores 2008; Malek et al. 2007. 