<qa>  What is the MSK-IMPACT assay?Note: The MSK-IMPACT Integrated Mutation Profiling for Actionable Cancer Targets assay is a next generation genomic profiling performed on formalin-fixed, paraffin-embedded FFPE tumor tissue in a CLIA-certified Molecular Diagnostic Service laboratory. IMPACT provides full exon coverage of 410 cancer related genes and can detect base substitutions, small indels, copy number alterations and selected gene re-rearrangements. In some cases, additional assays such as Sanger Sequencing or fluorescence in situ hybridization FISH may be required to confirm specific results detected on IMPACT. Patients at MSK will have this assay to determine eligibility. Use of other validated next-generation sequencing techniques for eligibility may be considered, provided they are performed in a CLIA-certified laboratory and are approved by the MSK Principal Investigator. 