<qa>  What is the chemiluminescent immunometric assay?vi Analysis of Biomarkers for Inflammation, Cardiac fibrosis and Cardiac Function: : Chronic inflammation will be quantified by serum levels of high sensitivity C-reactive protein hsCRP using a chemiluminescent immunometric assay Immulite 2500 at 0,20 and 40 weeks. Serum samples stored at -700 C and batch analysed for PICP RIA- Framos Diagnostica, MMP1 and TIMP 1 ELISA- Amersham at University of Pamplona and Plasma NT proBNP will be measured by the Elecsys proBNP immunoassay on the Roche Elecsys 1010 immunoassay analyzer at baseline and at study completion. 