<qa>  What is the primary endpoint?The primary endpoint is the change in mean flow velocity in the middle cerebral arteries measured by transcranial doppler. The secondary endpoints are the effects on the peripheral endothelium, hereby: 1 changes in the reactive hyperaemia index measured by EndoPAT2000, 2 changes in the ankle-brachial index, and 3 changes in endothelialinflammatory biomarkers in the blood. The primary and secondary endpoints are measured before and up till three hours after administration of exenatide. 