<qa>  What is the dichotomous approach established by Rasmussen et alThe neuropsychological assessment is performed at preoperative baseline, after 5-7 days and at three months follow up, and in some studies additionally at 1year, 2 year and 5 year follow-up. Postoperative cognitive dysfunction POCD will be classified using different calculation methods, primarily the dichotomous approach established by Rasmussen et al. in the International Study on postoperative cognitive deficits ISPOCD. This calculation method defines POCD as a reliable change in pre- and postoperative cognitive performance difference scores of each individual in the surgical patients cohort as compared to the changes in a non-surgical control group reliable change index in either a composite score including cognitive test parameters from all tests in the cognitive test battery or in at least two of the chosen cognitive test parameters. Additional calculation methods like g-factor, GCP and arbitrary definitions e.g. 20.20- rule will be used for detailed methodologic evaluation. 