<qa>  What is the therapeutic response to docetaxel?Biologic markers to be assessed: Docetaxel Taxotere may produce a therapeutic response by induction of programmed cell death or by inhibition of cell division. Hence, apoptosis by TUNEL assay and other regulatory molecules p53, bcl-2 and bax will be measured. Proliferation will be assessed by measuring Ki67. From animal models, antiangiogenic effects with docetaxel Taxotere have been described, and this would be assessed in these clinical samples by measuring VEGF and microvessel counting CD31. Remaining frozen tissue will be snap frozen and stored temporarily in liquid nitrogen for microarray analysis. 