<qa>  How many patients will be required to be refractory to Carfilzomi- Patients may have received prior Carfilzomib sensitive, relapsed and refractory all eligible but must be 4 weeks from last dosing of Carfilzomib. In the expansion cohort, at least 10 patients will be required to be refractory to Carfilzomib refractory defined as having evidence of disease progression while receiving Carfilzomib or within 60 days of stopping Carfilzomib therapy. 