<qa>  What is the oxidative stress in the plasma?- Intervention: 30 participants randomly assigned, to receive antioxidant vitamins C ascorbic acid and vitamin E d-alpha-tocopherol once a day or placebo for 12 weeks double-blind. In Study Period 2, all participants receive open active treatment. Outcome measures: improvement in plasma antioxidant levels, oxidative stress indicated by glutathione status, thiobarbituric acid reacting substances TBARS and carbonyl content of proteins and HPA axis response. Behavioral problems will be studied using Developmental behavior checklist and Teachers and Parent s Questionnaire, C. Keith Conners, also learning improvement will be analyzed using Wechsler Intelligence Scale for children at 0, 3, 6 months during the trial and 3 months after completing the treatment. 