<qa>  What is the standard therapy for patients with multiple myeloma?Autologous peripheral blood stem cell PBSC transplantation is now considered standard therapy in patients 65 ans with multiple myeloma. The Intergroupe Francophone du Myelome conducted a randomised trial of the treatment of multiple myeloma with high dose chemotherapy followed by either one or two successive autologous stem cell transplantation. The probabilities of event-free-survival and overall survival were doubled with a double transplant. The benefits were greatest among patients who had not had a very good partial response to the first transplant. 