<qa>  What is the frequency of symptoms on more than one-third of days for at least 3 months- Estimated frequency of symptoms on more than one-third of days for at least 3 months prior to screening eg, wheezing, breathlessness, chest tightness, cough, nocturnal awakening despite treatment with high dose ICS and long-acting β2-agonist LABA, with or without continuous oral corticosteroids 