<qa>  What are the main causes of transplant loss?Cardiovascular complications and chronic rejection are chief causes of transplant loss1,2. After renal transplantation patients are still characterized by their pre-existing arteriosclerotic changes 3. Endothelial dysfunction and disturbed distensibility of great arteries are independent predictors of cardiovascular morbidity 4,5. Additionally the activation of sympathetic nervous system leads to dysfunction of vessel wall6,7. There are important therapeutic options in improvement of endothelial function 8. 