 Ọrụ Sibutramine na-arụ ọrụ site nịmalite Serotonin na Norepinephrine etoju na ụbụrụ, ọ na-emepụta ọgwụgwọ ya site na mgbochi nke norepinephrine NE, serotonin 5-hydroxytryptamine, 5-HT, na nkwụsị nke nta, reuptake dopamine na synapse ahụ. 