<prompt> unaweza kugeuza matini haya ya swahilikwa kiingereza?imeandaliwa wakati wa kifungu cha kwanza kupitia ini na malezi ya metabolite ya carboxyl, ambayo ina shughuli ya kutamka ya dawa zaidi ya losartan, na metabolites kadhaa ambazo hazifanyi kazi.  <response>: metabolized at the first pass through the liver to form a carboxyl metabolite, which has a more pronounced pharmacological activity than losartan, and a number of inactive metabolites. 