<prompt> tafadhali geuza maudhui haya ya swahili kwenda kwa kiingereza.karibu 4 ya wagonjwa walio na nsclc wana upangaji wa chromosomal ambao hutengeneza jeni la fusion kati ya eml4 echinoderm microtubule-associated protein-like 4 na alk anaplastic lymphoma kinase, ambayo husababisha shughuli za kinase zinazochangia ugonjwa wa kasinojeni na inaonekana kuendesha phenotype mbaya.  <response>: about 4 of patients with non-small cell lung carcinoma have a chromosomal rearrangement that generates a fusion gene between eml4 echinoderm microtubule-associated protein-like 4 and alk, which results in constitutive kinase activity that contributes to carcinogenesis. 