<prompt> Principle building block in fatty acid synthesis:Acetyl CoAPalmitoyl CoAMalonyl CoAOleate  <response>: Ans. a Acetyl CoA Principle building block in fatty acid synthesis: Acetyl CoA Cofactors required: NADPH, ATP, Mn2 and HCO3 Source of Acetyl CoA: From mitochondria after aerobic glycolysis and Fatty acid oxidation Site of FA synthesis: Liver, Kidney, Brain, Lungs, Adipose tissue, Lactating breast Organelle: Extra-mitochondrial system in cytosol Enzyme: Acetyl CoA carboxylase-rate limiting enzyme Fatty acid synthase 