<prompt> Lisch nodule seen in:NeurofibromatosisTuberous sclerosisVon-Hippal Lindau syndromeTumour metastasis to brain  <response>: Neurofibromatosis 2457-H 16th 2607-H17th Neurofibromatosis Von Recklinghausens disease - cutaneous neurofibroma Cafe au lait spots Freckling in non-sun exposed areas such as the axilla, hamartoma of the iris termed Lisch nodules. Pseudoarthrosis of the tibia.Tuberous Sclerosis Bournvilleis diseaseCutaneous Lesions Adenoma sebaceus Facial angiofibromas Ash-leaf shaped hypopigmented macula Shagreen patch Yellowish thickening of the skin over lumbosacral region of the back Depigmented nevi Sub ependymal nodules Subependymal giant cell astrocytoma Rhabdomyomas of the myocardium and Angiomyomas of the kidney, liver, adrenal and pancreas.Von Hippel Lindav Syndrome - consist of retinal, cerebellar and spinal hemangioblastomas, Hypernephroma, renal cell carcinoma, pheochromocytoma, benign cysts of kidney, pancreas, epididymis or liver may occur. 