<prompt> Which of the following if combined with Rivastigmine, decreases its efficacySelective serotonin reuptake inhibitorsReversible inhibitor of MAO-ATricyclic antidepressantsAtypical antidepressants  <response>: Rivastigmine is used in Alzheimers disease. It inhibits acetylcholinesterase and increases the level of ACh.Tricyclic antidepressants have strong anticholinergic actions. Therefore, these can reduce the efficacy of Rivastigmine.Depression is commonly seen in patients with Alzheimers disease. The anti-depressants that are used should have minimum anticholinergic activity, therefore SSRI or MAO-inhibitors are preferred. 