<prompt> Amyloid stroma is seen with?Papillary carcinoma ThyroidMedullary carcinoma ThyroidFollicular carcinoma ThyroidAnaplastic carcinoma Thyroid  <response>: Ans. b Medullary carcinoma thyroidRef: Robbings pathology 9th ed. 1099MEDULLARY CARCINOMA THYROID Accounts for approximately 7 of malignant tumour of thyroid It arises from ultimo-branchial bodies from the para- follicular C cells derived from thyroid follicles. It contains amyloid stroma Familial medullary carcinomas occur in 25 of patients Marfanoid habitus, Amyloid disease also occur in patients with familial medullary cancer. Medullary carcinoma occurs in association with MEN syndrome. All patients with medullary carcinoma of thyroid should be screened for RET proto-oncogene. Medullary Carcinoma thyroid secretes calcitonin, this does not cause hypocalcemia 