<prompt> Commonest cardiac lesion in tuberous sclerosis isSDVSDMitral stenosisRhabdomyoma  <response>: Tuberous sclerosis complex TSC is an autosomal dominant neurocutaneous syndrome with a high incidence of sporadic cases and variable clinical expression. It has an estimated frequency of 16000. Major manifestations of TSC include skin lesions in more than 95, autism and seizures in 85, kidney disease in 60, mental retardation in 50, and cardiac rhabdomyoma in 50.Mental retardation and autism are more in TSC patients who presents with generalized seizures including infantile spasms in the first 2 years of life. Reference: GHAI Essential pediatrics, 8th edition 