<prompt> Renal cell carcinoma-Invades Renal VeinHematuria usually absentArises from proximal convoluted tubuleMore common in females  <response>: RCC commonly arise from the poles of the kidney as a solitary and unilateral tumor,more often in upper pole.The tumor has slight male preponderance2:1.One significant characteristic is the presence of tumor thrombus in the renal vein which may extend into the vena cava.The clinical features include a triad of gross hematuria ,flank pain,palpable abdominal mass. From Textbook of pathology HarshMohan ,7th edition pg no:681,682 