<prompt> McArdles disease is due to the deficiency of:Glucose 1 phosphataseGlucose 1, 6 diphosphataseGlucose 6 phosphataseMyophosphorylase  <response>: Ans: D Myophosphorylase Ref: Harpers illustrated Biochemistry,28th edition,Chapter 19,pp 160Explanation:McArdles diseaseType V Glycogen storage diseaseDeficiency: muscle phosphorylasemyophosp- horylasePremature chain termination, incorrect folding etc can cause loss of catalytic activitySkeletal muscle is affectedExercise-induced muscular pain, cramps, progressive weakness, myoglobinuriaNo increase in blood lactate after exerciseGlycogen storage disordersDisorderAffected TissueEnzyme defectType 0LiverGlycogensynthaseType I; Von GierkesLiver, kidney, intestineGlucose-6-phosphataseType II; PompesAilLysosomal alpha glucosidaseType III; ForbesLiver, muscle, heartGlycogendebranching enzymeType IV; AndersonsLiverBranching enzymeType V; Mc ArdlesMusclesmuscle phosphory laseType VI; HersLiverLiver phosphonlaseType VII; TaurisSkeletal muscle, RBCMuscle and Liver PFK 