<prompt> Active replication in Hepatitis B infection is indicated by?HBeAgHBsAgHBcAgAnti-HBsAg  <response>: o HBeAg is an indicator of active intrahepatic replication and high infectivity.o It is a qualitative marker of HBV replication.Serologic and virologic markers of HBV infection1. HBs Ago First virological marker detectable in the serumo HBsAg presence precedes elevations of serum aminotrans ferase activity and onset of clinical illness,o HBsAg become undetectable 1-2 months after the onset of jaundice and rarely persists beyond 6months,o In chronic HBV infection, HBsAg remains detectable beyond 6 months.2. HRcAgo It is not demonstrable in the circulation because it is enclosed within the HBs Ag coat,o HBc Ag remain in the hepatocyte, where it can readily be detectable by immunohistochemical staining.3. HBeAgo HBe Ag appears concurrently with or shortly after HBs Ag.o HBe Ag is an indicator of active intrahepatic replication and high infectivity.o It is a qualitative marker of HBV replication.o HBs Ag carrier mothers who are HBe Ag positive almost invariably 90 transmit hepatasis B infectionTo their offspring, where as HBs Ag carrier mothers with an HBe rarely 10 to 15 infect theiroffspring.o HBe testing is indicated primarily during follow up of chronic infection.4. And HBc Ago Appears w ithin the first 1 to 2 weeks after the appearance of HBs Ag.o In acute or recent infection IgM an HBc is detected.o IgG an HBc indicates remote infection.5. An HBsAgo It becomes detectable in blood when HBs Ag disappears,o An HBs Ag is protective antibody.o It is the only serological marker, present after immunization.6. An HBeAgo Disappearance of HBe Ag is followed by the appearance of anHBeAg.o Its presence indicates low infectivity and virus replication.7. HBVDNAo it is the quantitative marker of virus replication 