<prompt> Which of the following inflammatory mediator doesnt cause fever:Nitric oxideProstaglandinIL-1TNF-alpha  <response>: Pyrogens A pyrogen is a substance that induces fever. These can be either internal endogenous or external exogenous to the body. The bacterial substance lipopolysaccharide LPS, present in the cell wall of some bacteria, is an example of an exogenous pyrogen. Endogenous Pyrogens IL 1 TNF PGs Depyrogenation may be achieved through filtration, distillation, chromatography, or inactivation. 