<prompt> All of the following are invasive carcinoma breast exceptComedo carcinomaColloid carcinomaLobular carcinoma in situMedullary carcinoma  <response>: The comedo subtype is distinctive and is characterized by cells with high-grade nuclei with extensive central necrosis.The name derives from the toothpaste-like necrotic tissue that extrudes from transected ducts on application of gentle pressure ref : Robbins Basic Pathology, 9E,page-710 