<prompt> Mechanism of action of PaclitaxelIt prevents polymerization of tubulinIt enhance polymerization of tubulinCauses DNA breaks by affecting DNA topoisomerase II functionCause DNA breaks by affecting DNA topoisomerase I  <response>: It enhance polymerization of tubulin 774-KDT 825-KDT 6thMechanism of actionA. Vinca-Alkaloids Vincristine, Vinblastine - These are mitotic inhibitors bind to microtubular protein- tubulin prevent its polymerization and assembly of microtubules, causes disruption of mitotic spindle and interfere with cytoskeletal functions.B. Texanes Paclitaxel, Docetaxel - complex diterpintaxane. It enhances polymerization of tubulin cytotoxic action of Paclitaxel emphasizes the importance of tubulin-microtubule dynamic equilibrium.C. Epipodophvllotoxins Etoposid - plant glycoside, it is not mitotic inhibitor but arrest cells in the G2 phase and causes DNA breaks by affecting DNA topoisomerase II functionsD. Camptothecin analogues Topotecan and Irinotecan. They act in a manner similar to etoposide, but interact with a different enzyme DNA topoisomerase I 