<prompt> Neostigmine antagonizes non-depolarizing blockade by all of the following mechanisms except.Decreasing the breakdown of acetylcholine at the motor end platePreventing the K efflux from the cellIncreasing the release of acetylcholine at the motor end plateDepolarization at the motor end plate  <response>: Ans. B Preventing the K efflux from the cellRef: Katzung 10the p436; KDT 8the p375Neostigmine is an anti-cholinesterase. It inhibits the breakdown of ACh at the motor end plate. This results in the increased activity of ACh that causes depolarization of motor end plate by opening Na channels increasing the influx of Na. It possesses some direct agonistic activity on NM receptors resulting in depolarization. In addition, a minor effect to increase the release of ACh at motor end plate is also present. 