<prompt> What is the rationale behind xenobiotic metabolism by CYP enzymesIncrease in water solubilityIncrease in lipid solubilityConversion to an active metabolitesMakes it suitable to evaporate through skin surface  <response>: Refer Katzung 12thp53,54 The aim of xenobiotic metabolism is to increase water solubility so that these compounds can be excreted in urine 