<prompt> Blau syndrome is associated with mutation of:NOD2CARD 15 geneNOD 1CARD 1 geneNOD2CARD 10 geneNOD3CARD 12 gene  <response>: Ans: a NOD2CARD 15 geneRef: Harrison, 19th edition, Page 2215 and Genetic Home ReferenceBlaus syndromeCaused by mutations in CARD15 also known as NOD2, which regulates nuclear factor-xB activation.The protein produced from this gene helps defend the body from foreign invaders, such as viruses and bacteria, by playing several essential roles in the immune response, including inflammatory reactions.Inheritance - Autosomal dominant.Blaus syndrome is characterized by granulomatous dermatitis, uveitis and arthritis; distinct CARD15 variants predispose to Crohns disease.Recessive mutations in one or more components of the proteasome lead to excessive interferon signaling and the syndrome of chronic atypical neutrophilic dermatosis with lipodystrophy and elevated temperature CANDLE, a severe form of generalized panniculitis. 