<prompt> What is the best prognostic marker of CA penis:age 40 yrslesion size 2 cmprevious circumcisionabsent inguinal LN metastasis  <response>: The most important prognostic and treatment-related factor in penile ca is the presence and degree of nodal disease. Smiths Urology writes Survival in penile carcinoma correlates with the presence or absence of nodal disease.Five-year survival rates for patients with node-negative disease range from 65 to 90. For patients with positive inguinal nodes, this rate decreases to 30-50 and with positive iliac nodes decreases to less than 20. In the presence of soft-tissue or bony metastases, no 5-year survivors have been reported. 