<prompt> Increased intra-cranial tension is related to:Hyotension and tachycardiaHypertension and tachycardiaHypertension and bradycardiaHypotension and bradycardia  <response>: Ans. c Hypertension and BradycardiaRef: Harrison 18th edition, chapter 25 Cushings reflex a hypothalamic response to brain ischemia wherein the sympathetic nervous system is activated which causes increased peripheral vascular resistance with a subsequent increase in BP. The increased BP then activates the parasympathetic nervous system via carotid artery baroreceptors, resulting in vagal-induced bradycardia. The brain ischemia that leads to cushings reflex is usually due to the poor perfusion that results from increased ICP due to head bleeds or mass lesions. Cushings reflex leads to the clinical manifestation of Cushings triad. Cushings triad hypertension, bradycardia, and irregular respirations Cheyne-Stokes breathing. Cushings triad signals impending danger of brain herniation, and thus, the need for decompression. Consider administering mannitol, hyperventilation, and elevation of the head of bed as temporizing measures 