<prompt> In Beta thalassemia, the most common gene mutation is?Intron 1 inversionIntron 22619 bp deletion3.7 bp deletion  <response>: The most common mutation causing a thalassemia is intron 1 inversion b thalassemia- AR, caused due to reduced synthesis of beta chain of hemoglobin. b thalassemias are the consequence of various point mutations on the globin gene clusters. Thalassemia mutations in India Mutations Frequency IVS1-5G-C 48 619 bp deletion 18 IVS-1G-T 9 FR4142TCTT 9 FR89 G 5 Codonl5 G-A 5 Others 6 Total 100 