<prompt> All of the following statements about methotrexate are true EXCEPT:It is cell cycle specific and kills cells in the S phaseIts toxicity primarily affects bone marrow and epithelial structuresFolic acid reverses its toxic effectsIt is the drug of choice for choriocarcinoma  <response>: Folinic acid leucovorin is used to reverse the adverse effect of methotrexate. Folic acid is ineffective. All other statements are true 