<prompt> MOST common mutation seen in heriditary hemochromatosis is:C282YH63DTFR2SLC11A3  <response>: The most common mutation in hereditary hemochromatos is a homozygous G to A mutation resulting in a cysteine to tyrosine substitution at position 282 C282Y. Another relatively common mutation H63D results in a substitution of histidine to aspaic acid at codon 63. Mutations like transferrin receptor 2 TFR2 mutation and ferropoin 1 gene, SLC11A3 mutation are rare. Ref: Harrisons principles of internal medicine, 18th edition, Page: 3162 