<prompt> The commonest mode of inheritance of congenital hea disease isAutosomal dominantAutosomal recessiveSexlinked dominantMultifactorial  <response>: Ref Harrison 19 th ed pg 1516 The most common bih defects are cardiovascular in origin. These malformations are due to complex multifactorial genetic and environ- mental causes. Recognized chromosomal aberrations and mutations of single genes account for 10 of all cardiac malformations. Congenital hea disease CHD complicates 1 of all live bihs in the general population--about 40,000 bihsyear--but occurs more frequently in the offspring about 4-10, depending on maternal CHD type of women with CHD. Owing to the remarkable surgical advances over the last 60 years, 90 of afflicted neonates and children now reach adulthood; women with CHD may now frequently successfully bear children after competent repairs. 