<prompt> A child has microcephaly, Blue eyes, Fair skin, and Mental retardation, Ferric chloride test is positive. What is the likely diagnosis -Phenylketonuria PKUHomocystinuriaTyrosinosisAlkaptonuria  <response>: Ans. is a i.e., Phenylketonuria Clinical manifestations of phenylketonuria o Normal at bih o Symptoms occur after 1 months - i Mental retardation --- Not present at bih, develops gradually. ii Neurological signs -4 Irritability, tremors, convulsions, hyperkinesis and muscular hypeonia Exagerated reflex. iii Blond hair, blue iris, fair skin. iv Musty or mousy body odour. v Vomiting vi Microcephaly vii Enamel hypoplasia Growth retardation 