<prompt> Mutation in COL4A5 chain the diagnosis ?Alpos syndromeGood pastures syndromeHereditary Non-polyposis colon cancerKeroderma pigmentosum  <response>: Ans. is a i.e., Alpos syndromeo Manifestations of Alpos syndrome are due to abnormal a3 COL4A3, a4 COL4A4, or a5 COL4A5. o This is due to mutations of :i COL4A5 in classic X-linked formii COL4A.3 or COL4A4 in autosomal forms. 