<prompt> A 50-year-old patients pH- 7.05, HCO35 PCO212, BE30 mEqL. How much sodium bicarbonate to be given in first hour?100150250500 mLhours  <response>: Ans. a. 100Bicarbonate deficit can be calculated as follows:1st method by formula:HCO3- deficit0.5xbody weight in kgx24-HCO3- Half of the calculated deficit should be administered within the first 3-4 hours to avoid overcorrection and volume overload.2nd method: In general, severe acidosis pH7.10 warrants the IV administration of 50-100 mEq of NaHCO3 , over 30-45 min, during the initial 1-2 hours of therapy. 