<prompt> Antidote in Atropine poisoning is -FlumazenilPhysostigmineNaloxoneNaHCO3  <response>: Ans. is b i.e., Physostigmine o Atropine blocks cholinergic receptors. o So, for atropine overdose, we require a drug that increases cholinergic action, o Physostigmine increases the concentration of Ach. o Physostigmine counteracts central because it crosses BBB as well as peripheral symptoms of atropine toxicity other anticholinesterases like neostigmine and pyridostigmine counteract only peripheral symptoms as they cannot cross BBB - Physostigmine is the DOC. 