<prompt> Neurofibrillary tangles with senile plaques are seen in -Parkinsons diseaseAlzheimers diseaseSchizophreniaTuberous sclerosis  <response>: Neurofibrillary tangles with senile plaque are characteristic of Alzheimers disease. You should keep in mind that neurofibrillary tangles are not unique to Alzheimers disease; they also occur in own syndrome, dementia pugilistica punch drunk syndrome, Parkinson - dementia complex, hallervorden - Spatz disease, and Normally in old age. However, in these conditions, neurofibrillary tangles are without senile plaques. 