<prompt> Breast Ca most important prognostic factorLymph node statusSize of tumorSkin involvementPeude orange  <response>: Metastasis to ipsilateral axillary nodes predicts outcome are surgery more powerfully than tumor size does.The single most important predictor of 10 and 20-year survival rates in breast cancer is the number of axillary lymph nodes involved with metastatic disease. 