<prompt> Which local anaesthetic has highest protein binding capacity?LignocaineTetracainePrilocaineProcaine  <response>: Ans. B. Tetracaine. Ref. Clinical Anesthesia by Paul 5thpg. 458; Table 17-2sPhysicochemical Properties of Clinically Used Local Anesthetics:LOCAL ANESTHETICpKa IONIZEDat pH 7.4PARTITION COEFFICIENTLIPID SOLUBILITY PROTEIN BINDINGAMIDES Bupivacaine8.1833,42095Etidocaine7.7667,31794Lidocaine7.97636664Mepivacaine7.66113077Prilocaine7.97612955Ropivacaine8.18377594ESTERS Chloroprocaine8.795810not avail ableProcaine8.9971006Tetracaine8.5935,82294Additional Educational points: Speed Of Onset Is Related To - pKa Duration of action is related to - protein binding Potency is related to - lipidRelative Potency of Local Anesthetics for Different Clinical Applications: BUPIVACAINECHLORO- PROCAINELIDOCAINEMEPIVACAINEPRILOCAINEROPIVACAINEPeripheral nerve3.6NA12.60.83.6Spinal9.61111NAEpidural40.51114Dose-Dependent Systemic Effects of LidocainePLASMA CONCENTRATION mcgmLEFFECT1-5Analgesia5-10Lightheadedness Tinnitus Numbness of tongue10-15Seizures Unconsciousness15-25Coma Resp arrest25CVS depression 