<prompt> Hereditary spherocytosis is due to deficiency of:September 2007SpectrinPyruvate kinaseCytokeratinIntegrin  <response>: Ans. A: SpectrinHereditary spherocytosis HS is due to a deficiency of a protein called ankyrin.Ankyrins are cell membrane proteins thought to interconnect integral proteins with the spectrin-based membrane skeletonThe ankyrin of red blood cells erythrocytic ankyrin is called ankyrin-Rankyrin-1 ANK1. 