<prompt> 4yr old boy presenting with cryptorchidism, sho stature on auscultation, harsh ejection systolic murmur is heard in pulmonary area. What is the hematological abnormality found in this condition?Transient Myeloproliferative disorderJuvenile Myelomelanocytic leukemiaPseudo Pelger Huet anomalyBurkitt lymphoma  <response>: The history given in the question is suggestive of Noonan syndrome which is associated with Juvenile Myelomelanocytic leukemia; JMML. JMML BCRABL negative entity Regarded as MDSMPN syndrome Seen in children aged 4 years An aggressive disease characterized by proliferation of granulocytic and monocytic series. Peripheral blood: Leukocytosis with neutrophilia, monocytosis, nucleated red blood cells Bone marrow: Hypercellular with granulocytic hyperplasia; Monocytes, 5-30; Megakaryocyte decreased; Blasts promonocytes 20 Dysplasia, not prominent; Reticulin fibrosis Associated with Neurofibroma type 1 NF 1 Noonan syndrome Trisomy 8 mosaicism 