<prompt> HPV-related cervical intraepithelial neoplasia can be diagnosed by the presence of which of the following histologic features?Central, basophilic intranuclear cellular inclusionsCowdry type A intranuclear cellular inclusionsEnlarged multinucleated cellsCytoplasmic vacuolization and nuclear enlargement of cells  <response>: Human papilloma viruses HPV has one of Histologic feature in the form of cytoplasmic vacuoles and enlargement of Nucleus with hyperchromasia called as Koilocytosis. Altered keratinisation paicularly Hyperkeratosis and dyskeratosis is also seen. Cervical intraepithelial Neoplasm CIN occurs at the transitional zone. E6 and E7 proteins are involved in CIN pathogenesis. Option 1: Intranuclear basophilic inclusion bodies: Cowdry type B in Adenovirus Owls Eye Appearance in Cytomegalovirus. Option 2: Cowdry type A intranuclear inclusion Bodies: Herpes simplex or varicella zoster viruses. Option 3: Enlarged multinucleated cells are a special class of giant cell formed by the fusion of monocytesmacrophages, associated with foreign bodies ie, introduced exogenous materials or tissue response to infection. They also appear in autoimmune, neoplastic, and genetic disorders. 