<prompt> Pick the true statement about major criteria of Jones in acute rheumatic fever.Carditis is the earliest clinical manifestation seen in acute rheumatic feverSydenham chorea is a late manifestationInvolvement of small joints is a characteristic featureSubcutaneous nodule are seen on flexor aspects of the limbs  <response>: Major criteria Jones criteria for Acute Rheumatic fever Carditis Clinical andor subclinical Ahritis Polyahritis only Monoahritis or polyahritis or polyahralgia in moderate to high-risk populations Chorea Erythema marginatum Subcutaneous nodules There is a latent period of 3 weeks 1-5 weeks between the precipitating group A streptococcal infection and the appearance of the clinical features of ARF. The exceptions are chorea and indolent carditis, which may follow prolonged latent periods lasting up to 6 months. Syndenhams Chorea - commonly occurs in the absence of other manifestations, follows a prolonged latent period after group A streptococcal infection, and is found mainly in females. ARF almost always affects the large joints--most commonly the knees, ankles, hips, and elbows--and is asymmetric Subcutaneous nodules occur as painless, small 0.5-2 cm, mobile lumps beneath the skin overlying bony prominences extensor surfaces. 