<prompt> Cryptococcus is least likely to cause infection of -SkinBoneBrainKidney  <response>: Kidney is not involved in Cryptococcosis Clinical manifestations of Cryptococcosis: - Pulmonary cryptococcosis is the first and the most common presentation - Chronic meningitis - Skin lesions are commonly seen with C.neoformans var. neoformans serotype D - Osteolytic bone lesions. 