<prompt> . Primary biliary cirrhosis is positive forPANCAAnti-mitochondrial antibodyAnti nuclear antibodyAnti-microsomal antibody  <response>: Primary Biliary CirrhosisPBC - A progressive autoimmune liver disease characterised by non suppurative, inflammatory destruction of intra hepatic bile ducts. Characteristic autoantibody detected in primary biliary cirrhosis is antimitochondrial antibody Consequences: bile duct destruction-impaired secretion of bile, cholestasis, and inflammatory reaction in the poal tract-hepatic damage, fibrosis- cirrhosis and liver failure. SYSTEMIC AND GENERAL PATHOLOGY RAMDAS NAYAK PG NO 461 IMAGE REF: 