<prompt> Classical phenyl ketonuria is caused by deficiency ofPhenylalanine transaminasePhenylalanine hydroxylaseTyrosine transaminaseTyrosine hydroxylase  <response>: Phenylalanine hydroxylase 470 - RS 7th 366 - U.SPHENYLKETONURIA - 5 types of hyperphenylalaminemiasHYPER PHENYLALANINEMIASTypeConditionProbable enzyme defectTreatmentIClassical phenyl ketonuriaPhenylalanine hydroxylaseLow phenylalanine dietIIPeristent hyperphenyl alaninaemiaDecreased phenylalanine hydroxylase enzymeNone but temporary dietery therapyIIITransient mild hyperphenyl alaninaemiaMaturational delay of phenyl alanine hydroxylase enzymesSame as Type IIIVDihydropteridine reductase deficiencyDeficient or absent dihydropteridine reductaseDOPA, 5- 0 H tryptophan, carbidopaVAbnormal dihydrobiopterin functionDihydrobiopterin synthesis defectSame as type IV Alkaptonuria - homogentisate oxidase deficiency enzyme Type I Tyrosinaemia - Fumaryl acetoacetate hydrolase enzyme deficiency Type II Tyrosinaemia - Hepatic transaminase enzyme deficiency Hereditary tyrosinaemia - pOH - phenyl pyruvate oxidase enzyme deficiency 