<prompt> Which anesthestic modality is to be avoided in sickle cell diseaseGeneral anesthesiaBranchial plexus blockIntravenous regional anesthesiaSpinal anesthesia  <response>: Refer :Sho textbook of Anesthesia by Ajay Yadav 2e p 148 Prevention of conditions that our sickling is the basis of Peri operative management Supplemental oxygen is recommended Circulatory stasis can be prevented with hydration Normothermia is desirable The use of tourniquet and hence Biers block is contraindicated 