<prompt> Severe hepatotoxicity associated with steatohepatitis, most likely a result of mitochondrial toxicity, is being recognized with:ZidovudineDidanosineIndinavirAll  <response>: Severe hepatotoxicity associated with steatohepatitis, most likely a result of mitochondrial toxicity, is being recognized with increasing frequency with antiretroviral therapy with reverse transcriptase inhibitors e.g., zidovudine, didanosine or protease inhibitors e.g., indinavir, ritonavir. Reference: Harrisons Principles of Internal Medicine, 18th Edition, Page 2560 