<prompt> Notch effect in embryogenesis is an example of which type of signalling?AutocrineParacrineEndocrineNone of the above  <response>: One cell type produces the ligand, which then acts on adjacent target cells that express the appropriate receptor. The responding cells are in close proximity to the ligand-producing cell and are generally of a different type. Paracrine stimulation is common in connective tissue repair of healing wounds, in which a factor produced by one cell type e.g., a macrophage has a growth effect on adjacent cells e.g., a fibroblast. It is also necessary for hepatocyte replication during liver regeneration and for Notch effects in embryonic development, wound healing, and renewing tissues. Ref: Robbins 8th edition, Chapter 3 