<prompt> Which of the following antihypertensives is not given in pregnancy? AllMS May 2015. May 2014Enalaprila-methyldopaLabetalolNifedipine  <response>: Ans. a. Enalapril Ref: Goodman and Gilman 12e pe p736Enalapril is not given in pregnancy.ACE inhibitors inhibit the conversion of angiotensin-I to the potent vasoconstrictor angiotensin-II. They can cause severe fetal malformations that include hypocalvaria when given in the second and third trimesters. Because of this, they are not recommended during pregnancy. Angiotensin-receptor blockers act in a similar manner but instead of blocking the production of angiotensin-II, they inhibit binding to its receptor. They are presumed to have the same fetal effects as ACE inhibitors and are also contraindicated. - Goodman and Gilman 12e pe p736Antihypertensives to be avoided in Pregnancy Mnemonic: SAANDSodium nitroprussideQACE inhibitorsQARBsQNon-selective beta blockersQDiureticsQ 