<prompt> A female patient presented with a firm mass of 2 x 2 cms in the upper outer quadrant of the breast. She gives a family history of ovarian carcinoma. The investigation that needs to be done to assess for mutation is :p53BRCA-2Her 2Neu geneC-myc gene  <response>: Ans. is b BRCA 2 In women with hereditary breast - ovarian cancer, two susceptibility loci have been identified:BRCA -1 - located on chromosome 17 andBRCA - 2 - located on chromosome 13 - Harrison, 15e, p620 