<prompt> Which is the drug of choice in Pagets disease?AlendronateSteroidsAllopurinolCalcitonin  <response>: Treatment of Pagets disease Mithramycin Plicamycin, an anti-neoplastic agent toxic to osteoclast was the first drug used for pagets disease. DOC is Bisphosphonates - Etidronate was used first, Alendronate , Risedronate is preferred now. Calcitonin is used for acute relief of paintemporary effect. 