<prompt> Dantrolene is used in treatment ofMalignant hyperthermiaNeuroleptic malignant syndromeThyrotoxicosis-induced hyperthermiaAll of the above  <response>: Ans. d All of the above Ref. Harrisons Internal Medicine 17th edition, p. 121 Tripathi, p. 347DANTROLENE It inhibits Ry R Ca channel receptors and thus prevents the release of Ca2 from the sarcoplasmic reticulum of skeletal muscle. Uses:OrallyIVReduces spasticityMalignant hyperthermiaIn UML LesionsLeptic malignant syndromeMultiple sclerosisSerotonin syndromeCerebral palsyThyrotoxicosis-induced hyperthermia Dose of Dantrolene for Hyperthermia - 1-2 mgkg iv 6 hrly for 24-48 hrs. Adverse effects:u Muscle weakness, Diarrhea, Hepatotoxicity.Neuroleptic malignant syndrome NMS-- a se of antipsychotic drugs; Cf-rigidity, myoglobinuria, autonomic instability, hyperpyrexia. Treatment:dantrolene, D2 agonists e.g., bromocriptine.Malignant hyperthermia-- rare, life-threatening hereditary condition in which inhaled anesthetics except nitrous oxide and succinylcholine induce fever and severe muscle contractions. Treatment: dantrolene.Also know: other Se of inhalational anaesthetics: Hepatotoxicity halothane, nephrotoxicity methoxyfiurane, proconvuisant enfturane, expansion of trapped gas in a body cavity nitrous oxide.Educational Points:DiseaseKey featureHyperthermia-Hypothalamic set point not elevatedMalignant Hyperthermia -Halothane SchSerotonin Syndrome -SSRIs and when MAO inhibitors or TCA are given 