<prompt> Colon carcinoma is associated with all except:RbMismatch repair genesAPCb-catenin  <response>: - Rb gene mutation is associated with Retinoblastoma of eye not Colon cancer. Genetic risk factors of colon cancer: HNPCC Lynch syndrome CEO syndrome caused dt defect in DNA mismatch repair genes resulting in microsatellite instability - Cancer. FAP caused dt defect in APCb-catenin pathway resulting in- increased adenomatous polyps - increased risk of colon cancer Etiology Molecular defect Target gene Transmission Familial adenomatous polyposis APCWNT pathway APC Autosomal dominant Hereditary nonpolyposis colorectal cancer DNA mismatch repair MSH2, MLH1 Autosomal dominant Sporadic colon cancer APCWNT pathway APC None Sporadic colon cancer DNA mismatch repair MSH2, MLH1 None 