<prompt> Macroglobulin is derived fromB cellsT cellsBothNK cells  <response>: Ref Robbins 9e p191 alpha-2-Macroglobulin a2M is a large 720 KDa plasma protein found in the blood. It is mainly produced by the liver, and also locally synthesized by macrophages, fibroblasts, and adrenocoical cells. In humans it is encoded by the A2M gene 