<prompt> A patient presents with a unilateral ca breast of 4 cm size with skin ulceration involving the nipple. On palpation axillary lymph nodes are positive. Management would involve:Breast conserving procedureSimple mastectomyModified radical mastectomyPalliative treatment  <response>: Here this patient is having Stage III disease T4, N1 or N2, M0 according to the TNM table given above. Hence the management would be - Neoadjuvant chemotherapy MRM adjuvant radiation therapy chemotherapy antiestrogen therapy 