<prompt> A newborn presented with bloated abdomen sholy after bih with passage of less meconium. A full thickness biopsy of the rectum was carried out. Which one of the following rectal biopsy findings is most likely to be present?Fibrosis of submucosaHyalinization of the muscular coatThickened muscularis propriaLack of ganglion cells  <response>: Hirschsprungs disease:- Absence of ganglion cells- MC pa - rectum Sigmoid- Affected segment - Contracted Narrowed - Longer narrower the segment - More are SS of Intestinal obstruction Dx -Full thickness Rectal biopsy 