<prompt> Most emetogenic anti CA drug:5 FUMethotrexateCisplatinAll  <response>: Ref: Katzung 14th ed. pg. 956; KDT, 6th ed. pg. 828 Cisplatin is a platinum coordination complex that is hydrolyzed intracellularly to produce a highly reactive moiety which causes cross linking of DNA by platinum compound. It is a highly emetic drug. Antiemetics are routinely administered before infusing cisplatin. DOC for cisplatin induced vomiting: Ondansetron Major se of cispltin: Ototoxicity and nephrotoxicity. 