<prompt> Prions are best killed by -Autoclaving at 121degC5 formalineSodium hydroxideSodium hypochloride  <response>: Ans. is c i.e., Sodium hydroxide o Incineration is apparently the only way of disinfecting prion-contaminated materials or tissues,o Boiling or irradiation have no effect and even routine autoclaving at 1210C is not reliable. Therefore, where there is a risk of exposure, surgeons use disposable instruments.o To sterilize reusable instruments, WHO currently recommends combined use of a strong solution of sodium hydroxide and extended autoclaving at 134degC.Autoclaving at 134C for 5 hrs or treatment with 2 N NaOH for several hours is recommended for sterilization ofprions . -- Harrison 