<prompt> Significance of difference between two proportions is best studied by:t testChi square testANOVARegression coefficient  <response>: Ans: B Chi square test Ref: Textbook of Preventive and Social Medicine, K Park,20th edition, page no:755.Explanation:CHI-SQUARE TESTChi-square x2 Test is the best method for testing the significance of difference between two proportions.It has the advantage that it can also be used when more than two groups are to be compared. 