<prompt> Acrodermatitis enteropaihica is seen in deficiency ofMolybdenumZincSeleniumChromium  <response>: Ans. b Zinc Ref. Robbins 7h461; Table 9.24; H-17th Table 71-2Robbins 7thp. 461Essential features of zinc deficiency are: Distinctive rash, often around the eyes, nose, mouth, anus and distal parts. Anorexia, often accompanied by diarrhoea Growth retardation in children Impaired wound healing Hypogonadism with i reproductive capacity. Altered immune function Impaired night vision related to altered vitamin A metabolism Depressed mental function Increased incidence of congenital malformation in infants of Zn-deficient mothers.Micro and macroelementslementDeficiencyToxicityTolerable Upper Dietary Intake LevelBoronNo biologic function determinedDevelopmental defects, male sterility, testicular atrophy20 mgd extrapolated from animal dataCalciumReduced bone massosteoporosisRenal insufficiency milk-alkali syndrome, nephrolithiasis, impaired iron absorption2500 mgd milk-alkaliCopperAnemia, growth retardation, defective keratinization and pigmentation of hair, hypothermia, degenerative changes in aortic elastin, osteopenia, mental deteriorationNausea, vomiting, diarrhea, hepatic failure, tremor, mental deterioration, hemolytic anemia, renal dysfunction10 mg d liver toxicityChromiumImpaired glucose toleranceOccupational: renal failure, dermatitis, pulmonary cancerNDFluorideDental cariesDental and skeletal fluorosis, osteosclerosis10 mgd fluorosisIodineThyroid enlargement, T4, cretinismThyroid dysfunction, acne-like eruptions1100 gd thyroid dysfunctionIronMuscle abnormalities, koilonychia, pica, anemia, work performance, impaired cognitive development, premature labor, perinatal maternal mortalityGastrointestinal effects nausea, vomiting, diarrhea, constipation, iron overload with organ damage, acute systemic toxicity45 mgd of elemental iron GI side effectsManganeseImpaired growth and skeletal development, reproduction, lipid and carbohydrate metabolism; upper body rashGeneral: Neurotoxicity, Parkinson-like symptoms Occupational: Encephalitis- like syndrome, Parkinson-like syndrome psychosis, pneumoconiosis11 mgd neurotoxicityMolybdenumSevere neurologic abnormalitiesReproductive and fetal abnormalities2 mgd extrapolated from animal dataSeleniumCardiomyopathy, heart failure, striated muscle degenerationGeneral: Alopecia, nausea, vomiting, abnormal nails, emotional lability, peripheral neuropathy, lassitude, garlic odor to breath, dermatitis Occupational: Lung and nasal carcinomas, liver necrosis, pulmonary inflammation400 gd hair, nail changesPhosphorousRickets osteomalacia, proximal muscle weakness, rhabdomyolysis, paresthesia, ataxia, seizure, confusion, heart failure, hemolysis, acidosisHyperphosphatemia4000 mgdZincGrowth retardation, taste and smell, alopecia, dermatitis, diarrhea, immune dysfunction, failure to thrive, gonadal atrophy, congenital malformationsGeneral: Reduced copper absorption, gastritis, sweating, fever, nausea, vomitingOccupational: Respiratory distress, pulmonary fibrosis40 mgd impaired copper metabolism 