<prompt> Major source of collagen in cirrhosis?Kupfer cellsIto cell Hepatic stellate cellHepatocyteCanalicular cell  <response>: Ans. is b i.e., Ito cell hepatic stellate cellPerisinusoidal stellate cells Ito cells play a role in the storage and metabolism of vitamin A and are transformed into collagen producing myofibroblasts when there is inflamation of the liver.These cells are the major source of collegen in cirrhosis. 