<prompt> Itch sensation from skin is carried byA alphaA gammaC-nerve fibreCentral itch centre  <response>: C C-nerve fibre Itch Pathway: from Skin - C- Nerve Fibers - Dorsal Horn - Spinal Cord - Thlamus - Insula Itch or Pruritus, is the major symptom in skin diseases with a variety of etiologies and pathophysiologies. Significant progress has been achieved in understanding the pathophysiology of itch in the last 5 years. Neurophysiological experiments in humans and animals have revealed that itch is carried by specific C nerve fibers. Peripheral mediators other than histamine are involved in induction of itch. Mast cell tryptase seems to be an important mediator in itch by its activation of proteinase activated receptor 2 in the sensory nerves. 