<prompt> Which of the following is classified under Grade II acute cholecystitis according to the Tokyo Consensus Guidelines?Presence of multiorgan dysfunctionWBC count 11000mm3Mild local inflammationDuration of complaints 72 hours  <response>: Tokyo Consensus Guidelines for severity grading of acute cholecystitis: Grade I mild acute cholecystitis Acute cholecystitis in a healthy person with no organ dysfunction and mild inflammatory changes in the gallbladder Grade II moderate acute cholecystitis Associated with any one of the following:1. Elevated WBC count 18000mm32. Palpable tender mass in the right upper abdominal quadrant3. Duration of complaints 72 hours4. Marked local inflammation gangrenous cholecystitis,pericholecystic abscess, hepatic abscess, biliary peritonitis,emphysematous cholecystitis Grade III severe acute cholecystitis Associated with any one of the following: 1. CVS dysfunction- Hypeension requiring treatment with dopaminenorepinephrine 2. Neurological dysfunction- Decreased level of consciousness 3. Respiratory dysfunction- PaO2FiO2 ratio 300 4. Renal dysfunction- Oliguria; creatinine 2.0mgdL 5. Hepatic dysfunction- PT-INR 1.5 6. Haematological dysfunction- Platelet count 100000mm3 