<prompt> The following has least anti-cholinergic side effects:ClomipramineDesipramineImipramineTrimipranine  <response>: Ans: B Desipramine Ref: Kaplan Sadoeks Synopsis of Psychiatry. 10th edition. P.1109 and Kishore-Komar R et at. Desipramine relieves postherpetic neuralgia. Clin Pharmacol Then 1990 Mar; 473:305-12Explanation:Desipramine has the least anticholinergic and sedative effects of the tricyclic anti-depressant agents.All are tricyclic amine used to treatDepression Unipolar. NOT Bipolar since the risk of switch is highOCD ClomipraminePain syndromes AmitriptalineNocturnal enuresis ImipramineAcid peptic disease DoxipinMechanism of action: They block the transporter proteins of Nor-epinephrine and Serotonin, thereby elevating the level of both at synaptic cleft -enhanced activity of these neurotransmitters - mood elevationreduction of anxiety.Side-Effects are:Anticholinergic Side-EffectsDry mouthTachycardia QT intervalHeart blockConstipationPrecipitation of angle-closure glaucomaOrthostatic hypotensionThe other drugs related to them are:Tetracyclics-Amoxapine. Mirtazapine, Mians- erineMonoamine oxidase inhibitors MAOIs1. Irreversible monoamine oxidase inhibitors: Selegi1ine, Tranycypromine2. Reversible monoamine oxidase inhibitors: Moclobemide. Pirlindole 