<prompt> Which of the following drugs is preferred for management of depression associated with insomnia?MiazapineVenlafaxineSeralineDesipramine  <response>: In a depressed patient with significant insomnia, miazapine appears to be the most effective therapy. Miazapine is Atypical antidepressant MOA: Blocks a2 auto- on NA neurons and hetero on 5-HT neurons receptors enhancing both NA and 5-HT release. SSRIs commonly cause insomnia and avoided in patients with significant insomnia. 