<prompt> Scl-70 antibody is characteristics ofSLESclerodermaDermatomyositisSjogerns syndrome  <response>: Ref Robbins 7e p229 DNA topoisomerase I anti-Scl 70, is highly specific; it is present in as many as 70 of patients with diffuse scleroderma and in less than 1 of patients with other connective tissue diseases and is a marker for the devel- opment of more aggressive disease with pulmonary fibro- sis and peripheral vascular changes. The other ANA is an anticentromere antibody, found in as many as 90 of patients with limited scleroderma i.e., the CREST syn- drome; it indicates a relatively benign course. 