<prompt>  Sickle Cell anaemia all are true exceptThe shift from HbF to HbS occurs due to point mutation.Microvascular occlusion is a severe complication of SCADeoxygenation of RBC can lead to extensive membrane damageAdults but not children; with sickle cell disease are functionally asplenic, making them susceptible to infections caused by encapsulated bacteria, such as pneumococci. 