<prompt> Increased vascular permeability in acute inflammation is due to -HistamineIL 2TGF betaFGF  <response>: Ans. is a i.e., Histamine EFFECTS OF VARIOUS MEDIATORSo Various effects of inflammatory mediators areIncreased vascular permeability Histamine, serotonin 5-hydroxytryptamine, anapkylotoxins C3a, C4a, C5a, PAF, leukotrienes LTC4, D4, E4, bradykinin. PAF is the most potent one to increase permeability.ChemoattractantC5a most potent, IL-8, LTB4, PAF, bacterial products, Lymphokine, Kallikrein. C5a is the most potent chemoattractant.Vasodilatation Histamine, prostaglandins PG D2, PGE2, prostacyclins PGI2, serotonin. Nitric oxide, bradykinin.Vasoconstriction Leukotrienes LTC4, D4, E4, Th rom boxane A2.Bronchoconstriction Leukotrienes LTC4, D4, E4, PFA, histamine, bradykinin. Leokotrienes LTC4, D4, E4 are most potent bronchoconstrictors.Pain Prostaglandins, bradykinin.Fever pyrogens IL-1, TNF-al IL-6, prostaglandins, interferon. 