<prompt> Michaelis Menten Hypothesis states thatRate of enzymatic reaction is independent of substrate concentrationRate of non enzymatic reaction is proportional to substrate concentrationKm is the enzyme substrate complex association constantEnzyme substrate complex formation is essential in enzymatic reaction.  <response>: Michaelis-Menten Theory Enzyme-Substrate Complex Theory Enzyme combines with a substrate to form a transient Enzyme-Substrate Complex which immediately break into Enzyme and products. 