<prompt> Antinuclear antibody specific for SLE isAnti ds DNAAnti nuclear antibodiesAnti centromere antibodyAnti histone Ab  <response>: Systemic lupus erythematosus SLE is a multisystem autoimmunedisease of protean manifestations and variableclinical behavior. Clinically, it is an unpredictable, remittingand relapsing disease of acute or insidious onset thatmay involve viually any organ in the body; however, itaffects principally the skin, kidneys, serosal membranes,joints, and hea.Antibodies to doublestranded DNA dsDNA and the so-called Smith Sm antigen can be detected by ELISA or multiplex flow methods and are specific for SLE.Robbins Basic pathology,9th edition,pg no.127 