<prompt> Streptokinase and urokinase are contraindicated in-Intracranial malignancyPulmonary embolismAV fistulaThrombophlebitis  <response>: Ref: R Alagappan - Manual of Practical Medicine 4th Edition.pg no:188-189 Agents without fibrin specificity: 1. Streptokinase - 1.5 million units IV infusion over 60 minutes 2. Urokinase Because of the development of antibodies, patients who were previously treated with streptokinase should be given an alternate thrombolytic agent. Contraindications for Thrombolytic Therapy Absolute contraindications: Active bleeding Defective haemostasisRecent major trauma Surgical procedures 10 days Invasive procedures 10 days Neurosurgical procedure 2 months GIgenito-urinary bleeding 6 months StrokeTIA 12 months Prolonged CPR 10 minutes HO CNS tumour, aneurysm, AV malformation Active peptic ulcer Aoic dissection Acute pericarditis Active inflammatory bowel disease Active cavitary lung disease Pregnancy Relative contraindications: Systolic BP 180 mm Hg Diastolic BP 110 mm Hg Bacterial endocarditis Haemorrhagic diabetic retinopathy HO intraocular bleeding Chronic warfarin therapy Severe renal or liver disease Severe menstrual bleeding 