<prompt> Lacunar cells are seen inLymphocyte predomninat HLLymphcyte depleted HLNodular sclerosisMixed cellularity  <response>: Hodgkins LymphomaHodgkin lymphoma encompasses a group of lymphoid neoplasmsArise almost invariably in a single lymph node or chain of lymph nodes and spread characteristically in a stepwise fashion to the anatomically contiguous nodes. Hence staging is impoant.Its characterized by presence of noeplastic giant cells called as Reed-Sternbergs cell with two nuclear lobes, large inclusion-like nucleoli and abundant cytoplasm.Classification1.Nodular sclerosis2.Mixed cellularity3.Lymphocyte rich4.Lymphocyte depleted5.Lymphocyte predominanceCharacteristics of different subtypes of Hodgkin lymphomaSubtypeMorphology Background infiltrateImmunophenotypeNodular sclerosisLacunar cellsOccasional RS cellsT cells, esinophils, macrophages, plasma cellsCD15 CD30 EBV-Mixed cellularityMononuclear cells Hodgkin cell RS cellT cells, esinophils, macrophages, plasma cellsCD15 CD30 EBV 70Lymphocyte richMononuclear cells Hodgkin cell RS cellT cells richCD15 CD30 EBV 40Lymphocyte depletedFrequent RS cellsPaucity of background reactive cellsCD15 CD30 EBV 90Lymphocyte predominanceFrequent LH popcorn cellsFollicular dentritic cells and reactive B cellsCD15- CD30- EBV- CD20Note: 1 LH - lymphocytic and histiocytic variant of Hodgkin lymphoma seen in Lymphocyte predominant subtype. 2 CD 15 and 30 are the classical markers of Hodgkin lymphoma 3 Lymphocyte predominant is different from the other 4 subtypes of Hodgkin lymphoma. Hence called as a NONCLASSICAL variant.4 Prognosis Excellent - Nodular sclerosis, Mixed cellularity, Lymphocyte-rich, Lymphocyte predominant Less orable- Lymphocyte depletedRef: Robbins 8e p618, 7e p422-423 