<prompt> Presence of nephroblastomatosis in a biopsy specimen from Wilms tumor of left kidney indicates high possibility ofDenys-Drash syndromeMutation in insulin like growth factorIncreased risk of tumor in right kidneyLymph node metastasis  <response>: Presence of nephrogenic rests nephroblastomatosis in resected specimen indicates an increased risk of developing Wilms tumor in contralateral kidney. Nephrohlastomatosis also ka nephrogenic rests or nodular renal blastema, refer to the abnormal persistence of embryonal renal tissue. These are supposed to be precursor lesions of Wilms tumor. These are seen in renal paraenchyma adjacent to tumors in approx. 25 to 40 of unilateral and 100 of bilateral tumors. Presence of nephrogenic rests in resected specimen indicates an increased risk of developing Wilms tumor in contralateral kidney. So these patients will require frequent and regular radiological surveillance with CT scan for many years. Ref : Nelson Pediatrics 18e p2140-2143 