<prompt> Which of the following is feature of arsenic toxicity?Cirrhosis of liverNon-cirrhotic portal fibrosisHepatocellular carcinomaHepatoma  <response>: Ans. b Non-cirrhotic portal fibrosis C. HCC. Ref. Robbins pathology, 7th ed., pg 907; Table 18-8Hepatocellular damageExamplesAngiosarcomaVinyl chlorideNCPFArsenicMicrovesicular fatty changeTetracycline, salicylates yellow phosphorus, ethanolMacro vesicu lar fatty changeEthanol, methotrexate, amiodaroneCentrilobular necrosisBromobenzane, CCI4, acetaminophen, halothane, rifampinDiffuse or massive necrosisHalothane, isoniazid acetaminophen, methyldopa, trinitrotoluene,Amanita phylloides mushroom toxinHepatitis, acute and chronicMethyldopa, isoniazide, nitrofurantoin, phenytoin, oxyphenisatinFibrosis-cirrhosisEthanol, methotrexate, amiodarone, most drugs that cause chronic hepatitisGranuloma formationSulfonamides, methyldopa, quinidine, phenylbutazone, hydrala zine, allopurinolCholestasis with or without hepato cellular injury contraceptives, organic arsenicalsChlorpromazine, anabolic steroids, erythromycin estolate, oralContraceptives, organic arsenicals 