<prompt> A inhalation anaesthetic agent was used in a surgery which caused high output renal failure. The agent is:MethoxyfluraneDiethyl etherEnfluraneHalothane  <response>: Methoxyflurane was the most potent inhalation agent, but its high solubility and low vapor pressure yielded longer inductions and emergences. Up to 50 of it was metabolized by cytochrome P-450 CYP enzymes to free fluoride F-, oxalic acid, and other nephrotoxic compounds. Prolonged anesthesia with methoxyflurane was associated with a vasopressin-resistant, high-output, renal failure that was most commonly seen when F- levels increased to greater than 50 micro molL. Ref: Butterwoh IV J.F., Butterwoh IV J.F., Mackey D.C., Wasnick J.D., Mackey D.C., Wasnick J.D. 2013. Chapter 8. Inhalation Anesthetics. In J.F. Butterwoh IV, J.F. Butterwoh IV, D.C. Mackey, J.D. Wasnick, D.C. Mackey, J.D. Wasnick Eds, Morgan Mikhails Clinical Anesthesiology, 5e. 