<prompt> A 75-year-old man presents to his GP for a routine check-up. On examination the GP hears a high-pitched diastolic murmur, heard loudest at the right sternal edge and on expiration. Given the likely diagnosis, which of the following is NOT a risk factor for this condition?Ankylosing spondylitisMarfans syndromeHolt Oram SyndromeInfective endocarditis  <response>: Aoic regurgitation, High pitched diastolic murmur heard in case of AR Best heard on the left side. Option A: MC cardiovascular disease in Ankylosing spondylitis A.R. Option B: Marfan syndrome is a Risk factor. Option C: ASD skeletal defectsAbsent radius bone - Holt Oram Syndrome In ASD shunt murmur is absent, in ASD it is flow murmur Mid diastolic murmur Option D: Inf. endocarditis- bacteria will invade the valve leaflet will contribute to developing Diastolic Murmur. 