<prompt> Carcinoembryonic antigens CEA is increased in all exceptLung cancerBreast cancerColon cancerOsteogenic sarcoma  <response>: Carcinoembryonic antigenCEA is a cell surface glycoprotein discovered by Gold and Freedman. It is normally produced by colonic epithelium. Its serum 12 life is up to 10 days and is cleared by liver through Kupffer cells. So its 12 life prolongs in cholestasis and hepatocellular dysfunction. Normal level is 2.5 ngml. Level 5 ngml is significant. Even though it is a widely used tumour marker, it has got low sensitivity. CEA is primarily associated with colorectal cancers, but it can also increase significantly in pancreatic, gastric, lung, breast carcinomas. Often its level also increases in nonmalignant conditions like pancreatitis, hepatitis, obstructive jaundice, BPH. Reference : page 906 SRBs manual of surgery 5th edition 