<prompt> Anaplasia in Wilms tumor is evident by -Increased mitosisPleomorphic nucleiLarge nucleusAll  <response>: Ans. is a i.e., Increased mitosis; b i.e., Pleomorphic nuclei;ci.e., Large nucleus o It is very simple. Anaplasia anywhere is characterized by :- i Loss of polarity ii Hyperchromasia iii Increased nuclear cytoplasmic cell ratio increased nucleus size iv Pleomorphism v Increased number of mitosis which is atypical o The presence of anaplasia in Wilms tumor correlated with underlyingp53 mutations and emergence of resistance to chemotherapy. 