<prompt> Peripheral chemoreceptors responds to hyproxia by oxygen sensitive:Na channelCa2 channelK channelCI- channel  <response>: O2 levels are regulated almost entirely by peripheral chemoreceptors located in the carotid and aoic bodies; which in turn transmit appropriate signals to the respiratory center in the brain Carotid aoic bodies have GLOMUS CELLS multiple highly characteristic glandular - like cells that synapse directly with nerve endings. Glomus cells have O2 sensitive K channels that are inactivated when blood Po2 decrease markedly. HYPOXIA O2 sensitive K channels inactivated. Glomus cell depolarizes Voltage gated Ca channel open, increase intracellular Ca Neurotransmitter released, activates afferent neurons to CNS center of respiration. 