<prompt> Which of the following is most common hemoglobinopathy?ThalassemiaSickle cell anemiaHaemoglobin CChristmas disease  <response>: Any disease in which a mutation causes structurally abnormal hemoglobin is called HemoglobinopathySickle cell disease is a common hereditary hemoglobinopathy caused by a point mutation in b-globin that promotes the polymerization of deoxygenated hemoglobin, leading to red cell distoion, hemolytic anemia, microvascular obstruction, and ischemic tissue damage.Thalassemia is not considered as a type of hemoglobinopathy as the mutation causes absent globins, not abnormal globins. Ref: Robbins 9e p635 