<prompt> True statement about clonidine are all except ?Increases parasympathetic outflowDecreases sympathetic outflow by blocking central alpha receptorUsed in hypeensionPrazosin is used to antagonize side effects of clonidine  <response>: Ans. is d i.e., Prazosin is used to antagonize side effects of clonidine Clonidine is an a-2 agonist, while prazosin blocks the a-1 receptors. o Clonidine enhances vagal tone parasympathetic outflow which can cause bradycardia. o The major haemodynamic effects result from stimulation of a2a receptors present mainly postjunctionally in medulla -- decrease sympathetic outflow -- fall in BP and bradycardia. o Clonidine is used in hypeension. 