<prompt> Which of the following tumours have an increased elevation of placental alkaline phosphatase in the serum as well as a positive immunohistochemical staining for placental alkaline phosphatase -SeminomaHepatoblastomaHepatocellular carcinomaPeripheral neuroectodermal tumour  <response>: Alkaline phosphatase - There are four major sources of Alkaline phosphatase in the body. These are:-Liver Bone IntestinePlacentaSo the normal serum alkaline phosphatase consists of 4 isoenzymes secreted from the above-mentioned sites.Placental alkaline phosphatase is elevated in the following conditions -a Seminoma b Choriocarcinomac Third trimester of pregnancyAbout other options -In liver diseases and hepatocellular carcinoma the alkaline phosphatase elevated is of liver origin. Similarly the alkaline phosphatase elevated in bony diseases is due to some pathology in bone. 