<prompt> IL-1 is activated byCaspase 1Caspase 3Caspase 5Caspase 8  <response>: Pyroptosis is associated with release of cytokine IL 1 Microbial products that enter the cytoplasm of the cell are recognised by cytoplasmic immune receptors and activates a multiprotein complex called INFLAMMASOME Inflammasome will activate CASPASE 1 also called Interleukin 1 beta conveing enzyme and releases the active form of IL 1 Several NORs NOD like receptor signal INFLAMMASOME Gain of function in NLR can cause periodic fever syndromes called AUTO INFLAMMATORY SYNDROMES They respond to IL-1 antagonists IL 1 activates fibroblasts to synthesize collagen and stimulates the proliferation of mesenchymal cells IL 1 also stimulates Th17 responses Initiator caspase in Intrinsic pathway of apoptosis - IL 9 Initiator caspase in Entrinsic pathway of apoptosis - IL 8, 10 Executioner caspase of apoptosis IL 3 IL 7 Ref:- Robbins Basic Pathology 9th Edition; Pg num:- 59,86,188 