<prompt> Which of the following drug does not cross the blood-placental barrier?AtropineGlycopyrolatePhysostigmineHyoscine hydro bromide  <response>: Ref:KD Tripathi pharmacology 7th edition page.no: 19,116 Placental membranes are lipoidal and allow free passage of lipophilic drugs while restricting hydrophilic drugs. Glycopyrrolate is a quaternary ammonium compound. So it cant cross placenta and brainBBB. Other drugs can cross the placenta 