<prompt> A child with recurrent hypoglycemic attack and hepatomegaly is likely to haveVon Gierkes diseaseNeonatal diabetesNeonatal hepatitisGalactosemia  <response>: Recurrent hypoglycemic attack with hepatomegaly is seen in Type I glycogen storage disease Von Gierke disease.Glycogen storage diseases Glycogen storage diseases result from a hereditary deficiency of one of the enzymes involved in the synthesis or sequential degradation of glycogen.Clinical features depend on the type of enzyme deficiency and organ involvement.Glycogen storage diseases can be divided into:-1 Hepatic form Liver glycogenolysisThe liver is the key player in glycogen metabolism.It contains enzymes that synthesize glycogen for storage and ultimately break it down into free glucose, which is then released into the blood.So, An inherited deficiency of hepatic enzymes that are involved in glycogen metabolism leads toi Storage of glycogen in liver Hepatomegaly.ii Reduction in blood glucose Hypoglycemia.Examples of liver glycogenoses are -Type I glycogenosis Glucose - 6 - phosphatase deficiency Von Gierke disease.Type III glycogenosis Debranching enzyme defType IV glycogenesis Branching enzyme defType VI glycogenosis Liver phosphorylase def2 Myopathic form Muscular glycogenosesIn skeletal muscle, as opposed to the liver, glycogen is used predominantly as a source of energy.This is derived from glycolysis, which leads ultimately to the formation of lactate.So, enzyme deficiency leads to -Glycogen deposition in muscleMuscle cramp after exerciseThe exercise-induced rise in blood lactate levels owing to block in glycolysisThere may be myoglobinuriaExamples are -Type V glycogenosis phosphorylase deficiency McArdle disease.Type VII glycogenosis phosphofructokinase def3 Miscellaneous typesAssociated with glycogen storage in many organs and death in early life.Examples -i Type II glycogenosis Acid maltase deficiency Pompes disease 