<prompt> About first-order kinetics, the true statement isClearance remains constantFixed amount of the drug is eliminatedHalf life increase with doseDecreased clearance with increasing dose  <response>: Most of the drugs follow 1st order kinetics in 1st order kinetics-clearance is constant and, elimination is not saturable, and the rate of drug elimination is directly propoional to the concentration. This is usually referred to as first-order elimination Reference: Katzung Pharmacology; 13th edition; Chapter 3; Pharmacokinetics Pharmacodynamics: Rational Dosing the Time Course of Drug Action 