<prompt> Neurofibrillary tangles are seen in?Alzheimers diseaseLewy body diseaseNeurosyphilisShy dragger syndrome  <response>: ANSWER: A Alzheimers diseaseREF: Harrisons Internal Medicine 17th ed Chapter 365. DementiaAlzheimers disease most often presents with subtle onset of memory loss followed by a slowly progressive dementia that has a course of several years. Pathologically, there is diffuse atrophy of the cerebral cortex with secondary enlargement of the ventricular system. Microscopically, there are neuritic plaques containing A amyloid, silver-staining neurofibrillary tangles NFTs in neuronal cytoplasm, and accumulation of A42 amyloid in arterial walls of cerebral blood vessels.NFT also seen in supra nuclear palsy 