<prompt> True statement about acute hepatitis :In HCV, genotype 2 3 are most prevalent worldwideAnti-HCV antibody never present in 10 casesHEV-commonest cause of acute hepatitisHAV-more common in adult than children  <response>: Ans : B Anti-HCV... Age: Infection with HAV is more frequent among children than in adult-Park 21st190In patients with hepatitis C. an episodic pattern of aminotransferase elevation is common. A specific serologic diagnosis of hepatitis C can be made by demonstrating the presence in serum of anti-HCV. When contemporary immunoassays are used, anti-HCV can be detected in acute hepatitis C during the initial phase of elevated aminotransferase activity. This antibody may never become detectable in 5-10 of patients with acute hepatitis C, and levels of anti-HCV may become undetectable after recovery albeit rare from acute hepatitis C. In patients with chronic hepatitis C, anti-HCV is detectable in 95 of cases- Harrison 18th2551The average time from exposure to seroconversion is 8-9 weeks, and about 90 of patients are anti-HCV-positive within 5 months- Robbins 7th895Prevalence of hepatitis : HAV Worldwide, HBV Worldwide, HCV Probably worldwide, HDV Endemic area HEV Only developing countries- India, Asia, Africa, and Central America- Ananthanarayan 8th547TableThe B hepatitis is the most widespread the most important type of viral hepatitis Ananthanarayan 8th538HCV GENOTYPE Greenwood Microbiology 16th508There are six main genotypesl-6 a no. of commoner subtypes a, b, c1b:Commonest genotype worldwide. Older age group, risk factors generally ill-defined2a,b,c:Foundpredominan tly in older HCV-infected individuals from Mediterranean countries far east3a: Widely distributed in intravenous drug users, particularly from Europe 