<prompt> A patient of cirrhosis with liver failure comes to you for stem cell transplantation your method will be?Transfer of stem cells from other persons liverTaking patient skin stem cell and transferring into liverTranfer hepatocytes from the same person for regenerationTransfer hepatic progenitor cells HPCs of same person for regeneration  <response>: Ans. d Transfer hepatic progenitor cells HPCs of same person for regenerationRef: Nature Cell Biology 17, 971 -983 2015Hepatocytes and cholangiocytes self-renew following liver injury. But after severe injury like cirrhosis and acute liver failure hepatocytes are increasingly senescent. In this case there are two options: first diseased-donor liver and living- donor transplantation, in which a just portion of a healthy donors liver is used for transplantation or second hepatic progenitor cells HPCs, which contribute significantly to restoration of liver parenchyma, regenerating hepatocytes and biliary epithelia, highlighting their in vivo lineage potency. The best option is D among the options. 