<prompt> Dysplasia is characterized by all exceptHigh nuclear to-cytoplasmic ratioLoss of architectureDNB Nov. 13 PatternPleomorphismInvasion  <response>: Robbins basic pathology 9th edition page no 166 When dysplastic changes are marked and involve the entire thickness of the epithelium, the lesion is referred to as carcinoma in situ, a preinvasive stage of cancer. 