<prompt> True about pendred syndrome -Diffuse colloid goiterNodular goiterMental retardationAll  <response>: Ans. is a i.e., Diffuse colloid goiter; b i.e., Nodular goiter; c i.e., Mental retardation Pendred syndrome o It is an autosomal recessive disorder o Goiter with sensory neural deafness is seen in pendred syndrome. o Goiter is due to several mutation in TPO gene which lead to defective organification and congenital hypothyroidism. o Hearing loss is usually present at bih but goiter appears after pubey. o Goitre is usually soft and diffuse and later life become nodular. o It is due to defect in a sulfate transpoer protein common to thyroid gland and cochlea. 