<prompt> PEGLOTICASE IS USED FOR TREATMENT ?CPPDREFRACTORY RHEUMATOID AHRITISCHRONIC TOPHACEOUS GOUTANKYLOSING SPONDYLOSIS  <response>: PEGLOTICASE IS A RECOMINANT URICASE 3RD LINE AGENT ,GIVEN IV INFUSION EVERY 2WKS CI - IN G6PD DEFFICIENCY , METHYLHEAMOGLOBINEMIA REF: KD TRIPATHI 8TH ED 