<prompt> All are TRUE about diuretic associated hypokalemia, EXCEPT:Loop diuretic cause more hypokalemia than thiazide diureticsIncrease in distal tubular Na delivery and distal tubular flow rate results hypokalemiaSecondary hyperaldosteronism also plays a roleThiazides causes hypocalcuria  <response>: Diuretic use is an impoant cause of hypokalemia. Thiazides cause more profound hypokalemia than loop diuretics. MUST KNOW: Mechanisms of hypokalemia in diuretic use: Increases distal tubular Na delivery and distal tubular flow rate in addition to secondary hyperaldosteronism. Thiazides have an effect on plasma K concentration greater than that of loop diuretics. It is due to thiazide-associated hypocalciuria versus the hypercalciuria seen with loop diuretics. It reduces the lumen-negative potential difference and attenuating distal K excretion. ALSO NOTE: High doses of penicillin-related antibiotics nafcillin, dicloxacillin, ticarcillin, oxacillin, and carbenicillin can increase K excretion. Aminoglycosides, amphotericin, foscarnet, cisplatin, and ifosfamide cause renal K and magnesium wasting, leading to hypokalemia and hypomagnesemia Ref: Harrison, Edition-18, page- 352. 