<prompt> All of the following statements about the methotrexate are true exceptIt is a cell cycle specific and kills in the S phaseIts toxicity primarily affects bone marrow and epithelial structureFolic acid reverses its toxic effectsIt is a drug of choice for choriocarcinoma  <response>: Ref-KDT 6e p823 Folic acid is used to reverse the adverse effect of methotrexate. Folic acid is ineffective. All of the statements are true as discussed earlier 