<prompt> Good prognostic factor in ALL:Age 10HyperdiploidyMLL gene rearrangementst1:19  <response>: B i.e. HyperdiploidyRef: Robbins Pathologic Basis of Disease, 8th edition and Nelson, Textbook of Pediatrics Explanation:Common Chromosomal Abnormalities in the Acute Leukemias of ChildhoodDiseaseSubtypeChromosomal AbnormalityInfluence on PrognosisALLPre-BTrisomy 4 and 10Favorable t12;21 Pre-Bt4;11Unfavorable Pre-Bt9;22Unfavorable B-cellt8;14None GeneralHyperdiploidyFavorable GeneralHypodiploidyUnfavorablePrognosisMost children with ALL can now be expected to have long-term survival, with the survival rate 80 at 5 years from diagnosis.Important Prognostic FactorsChoice of appropriate risk-directed therapy.Type of treatment chosen.Type of ALL.Stage of disease.Age of the patient.Rate of response to initial therapy favorable if the patient responds in 1 month.Poor Prognostic IndicatorsAge 1 year or 10 years at diagnosis.Leukocyte count of 100,000pL at diagnosis; or aSlow response to initial therapy.Hypodiploidy.Philadelphia chromosome.MLL gene rearrangements.Translocations .Favorable Prognostic IndicatorsRapid response to therapy.Hyperdiploidy.Trisomy of specific chromosomes.Rearrangements of TELAML1 genes. 