<prompt> Prognostic factors of Ca. breast include all except:Erb B2EstrogenProgesteroneEcadherin  <response>: Ans: d E cadherin Ref: Robbins, 7th ed, p. 1147E cadherin is a glycoprotein that acts as glue between epithelial cells. Loss of cadherin favours malignancy by allowing easy disintegration of cells leading to local invasion metastasis. Even though reduced cell surface expression of E cadherin is associated with many types of carcinomas including Ca breast, its not mentioned as a prognostic factor major minor for the same.Prognostic factors - Ca. breast:Major:1. Invasive insitu - invasive poor prognosis2. Distant metastasis - poor prognosis3. Lymph node mets - Axillary LN status is the single most important prognostic factor in the absence of mets4. Tumour size - 2nd most important prognostic factor in the absence of mets5. Locally advanced disease - invading skin skeletal muscles - poor prognosis6. Inflammatory carcinoma - poor prognosisMinor:1. Histological subtype - No special type is poorer than special types like tubular, mucinous, medullary etc.2. Tumour grade - Scarff Blood Richardson system Higher the grade, poorer the prognosis3. Hormone receptors -Estrogen receptor, Progesterone receptor 80 respond to therapy.Either E or P 40 respond to therapyEstrogen -, progesterone - 10 respond to therapy4. Her 2neu Human epidermal growth factor receptor C erb B2Over expression is associated with poor prognosis 