<prompt> The site of action of the loop diuretic furosemide is:Thick ascending limb of loop of HenleDescending limb of loop of HenleProximal convoluted tubuleDistal convoluted tubule  <response>: Ans. a. Thick ascending limb of loop of Henle Ref: Goodman and Gilman : 12e p678The site of action of the loop diuretic furosemide is thick ascending limb of loop of Henle.DiureticSite of actionMechanism of actionCarbonic anbydrase inhibitorsProximal tubuleInhibit Na and HCO3 - absorption due to carbonic anhydraseQOsmotic diureticsLoop of HenleReduce renal medullary tonicityLoop diureticsThick ascending limb of loop of HenleInhibit Na - K 2CI- symporterQThiazidesEarly distal tubuleInhibit Na - Cl- symporterQAmilorideLate distal tubule, Collecting ductInhibit epithelial sodium channels ENaCQTrimaterenceLate distal tubule, Collecting ductInhibit epithelial sodium channels ENaCQAldosterone receptor antagonistsLate distal tubule, Collecting ductAntagonize the Na and H2O reabsorption due to aldosterone 