<prompt> Most common site of perforation of tympanic membrane in acute suppurative otitis media is:Anterior superior quadrantAnterior inferior quadrantPosterior superior quadrantPosterior inferior quadrant  <response>: In acute suppurative otitis media, 85 of cases show a small perforation in antero-inferior quadrant of pars tensa. Perforations in this location were associated with smooth margins, good drainage of pus, and a orable clinical course. Hence this area is termed as perforation zone. Only 15 of perforations occurred in other locations, most typically the posterior-superior quadrant. 