<prompt> Pathological feature characteristic of Parkinsons disease is?Neurofibrillary tanglesAmyloid plaqueLewy bodiesAll of these  <response>: Lewy bodies REF: Robbins 7th edition page 1351, 1391 In Parkinsons disease, on microscopic examination, there is loss of pigmented catecholaminergic neurons in these regions associated with gliosis. Lewy bodies may be found in some of the remaining neurons. These are single or multiple, cytoplasmic, eosinophilic, round or elongated inclusions that often have a dense core surrounded by a pale halo Major microscopic abnormalities ofAlzeimers disease are neuritic senile plaques, neurofibrillary tangles and amyloid angiopathy NEURODEGENETATIVE DISEASES ASSOCIATED WITH AGGREGATED PROTEINS: Disease Protein Normal structure AggregateInclusion Location Prion disease Prion protein PrP a helix random coil 3-pleated sheet, proteinase K-resistant Extracellular Alzheimer disease Amyloid precursor protein a helix random coil 3-pleated sheet, amyloid fragment of APP Extracellular Tauopathies and Alzeimer disease Tau microtubule binding protein 3 4 repeat isoforms Hyperphosphorylated aggregated proteins Intracellular Parkinsons disease a-Synuclein Random coil, Repeats Aggregated, Lewy bodies Cytoplasmic Multiple system atrophy a-Synuclein Random coil, Repeats Aggregated glial cytoplasmic inclusions Cytoplasmic Huntington disease Huntingtin Trinucleotide repeats Insoluble aggregates Nuclear Spinocerebellar ataxia Ataxins Trinucleotide repeats Insoluble aggregates Nuclear 