<prompt> A highly ionized drugIs excreted mainly by kidneyCan carry placental barrier easilyIs well absorbed from intestineAccumulates in cellular lipids  <response>: Ionized molecules cannot cross the biological membranes .therfore they are less likely to be absorbed . Entry of the molecules through blood brain barrier and blood placental barrier is also restricted .these drugs cannot be reabsorbed in the nephron,thus are excreted by the kidney . Refer kDT 7e p29 