<prompt> In comparing the de novo synthesis of IMP and UMP, which one of the following best represents commonalities in the pathways?Both Require PRPP - yes; Both Require Folate Derivatives - no; Both Require Glutamine - yes; Both Require Glycine - no; Both Require Aspartic Acid - yesBoth Require PRPP - yes; Both Require Folate Derivatives - no; Both Require Glutamine - no; Both Require Glycine - no; Both Require Aspartic Acid - yesBoth Require PRPP - yes; Both Require Folate Derivatives - yes; Both Require Glutamine - yes; Both Require Glycine - no; Both Require Aspartic Acid - noBoth Require PRPP - no; Both Require Folate Derivatives - yes; Both Require Glutamine - no; Both Require Glycine - yes; Both Require Aspartic Acid - yes  <response>: De novo purine and pyrimidine biosynthesis occurs in the liver and, to a limited extent, in the brain.In pyrimidine biosynthesis, carbamoyl phosphate, produced from glutamine, CO2 , and ATP, reacts with aspartate to form a base that, after oxidation, reacts with phosphoribosyl pyrophosphate PRPP to form a nucleotide. This nucleotide is decarboxylated to form UMP. In purine biosynthesis, the base is produced on ribose-5-phosphate, which is generated from PRPP. Glycine is incorporated into the precursor, and tetrahydrofolate derivatives donate carbons 2 and 8 as IMP is formed. Glutamine is a nitrogen donor for both purine and pyrimidine biosynthesis. Aspartate is required for both UMP and IMP synthesis. Aspartate is also required in the conversion of IMP to AMP. 