<prompt> More than 90 patients of CREST syndrome with the limited cutaneous form of this disorder make which of the following autoantibodies?Anti-centromereAnti-DNA topoisomerase lAnti-double-stranded DNAAnti-Golgi  <response>: All forms of scleroderma are thought to have a strong autoimmune component, and glucocoicoids and azathioprine are used to suppress the inflammatory complications of scleroderma. Other drugs that can be used in therapy include penicillamine, which inhibits collagen cross-linking, NSAIDS for pain, and ACE inhibitors to protect the kidney if hypeension or renal damage occurs. The anti-centromere antibody is quite specific for CREST syndrome 96 of cases, and is only seen in a minority of patients with diffuse scleroderma mainly those with Raynauds phenomenon and rarely in systemic lupus erythematosus and mixed connective tissue disease.Also know:Anti-DNA topoisomerase I , also called anti-Scl-70 occurs commonly 64-75 in diffuse scleroderma, but only rarely in CREST syndrome.Anti-double-stranded DNA is fairly specific for systemic lupus erythematosus, although it only occurs in 50-60 of lupus cases.Anti-Golgi antibodies are seen most often in systemic lupus erythematosus and Sjogren syndrome. Ref: Hellmann D.B., Imboden Jr. J.B. 2013. Chapter 20. Musculoskeletal Immunologic Disorders. In M.A. Papadakis, S.J. McPhee, M.W. Rabow Eds,CURRENT Medical Diagnosis Treatment 2013. 