<prompt> Werner disease is associated with?-Intestinal polypsMultiple cancerLax jointsPremature ageing  <response>: DNA repair mechanisms are defective in diseases such as Werner syndrome and ataxia-telangiectasia. Werner syndrome WS, also known as adult progeria, is a rare, autosomal recessive disorder which is characterized by the appearance of premature aging. Werner syndrome is named after the German scientist Otto Werner. 