<prompt> Granuloma formation is seen in Hypersensitivity reaction typeIIIIIIIV  <response>: IV: 74- Harsh Mohan 6th editionType IV: Delayed Hypersensitivity Cell Mediated ReactionExamples1. Reaction against mycobacterial infection eg tuberculin reaction, granulomatous reaction in tuberculosis, leprosy2. Reaction against virally infected cells3. Reaction against malignant cells in the body4. Reaction against organ transplantation eg transplant rejection, graft versus host reactionType I Anaphylactic, atopic Type II Cytotoxic Type III Immune- Complex, Arthus reaction1. Systemic anaphylaxis administration of antiseraATS and drugs Penicilline 1. Cytotoxic antibodies to blood cells Auto immune haemolytic anaemia, Transfusion reactions, Erythroblastosis foctalis, ITP, Leucopcnia, drug induced penicillin, methyl dopa, rifampicin I. Immune complex glomerulonephritisII. Goodpastures syndromeIII. Collagen disease SLE, RAIV. PANV. Drug induced vasculitis2. Local anaphylaxis hay fever, bronchial asthma, food allergy, cutaneous, angioedema 2. Cytotoxic antibodies to tissue components Gravis disease, M.gravis, male sterility, Type I DM, Hyper acute reaction against organ transplant 