<prompt> First Sign of Pubertal devlopment in female is -Enlargement of breastMenarcheAppearance of pubic hairAppearance of axillary hair  <response>: Ans. is Enlargement of breast o In male - Sequence of change 1. Growth of testes 3 ml in volume or thinning of scrotum 2-5 cm in longest diameter 2. Pigmentation of scrotum growth of penis 3. Pubic hair 4. Axillary hair o In female - 1. Breast bud - First sign 2. Pubic hair 3. Menarche 