<prompt> All are true regarding Crohns disease except:InfertilityRisk of CaMedical treatment includes antibiotics, probiotics and TNF alpha blockersASCA-negative  <response>: Ref: Harrison s Principles of Internal Medicine, 18th edition, pg 2486 Explanation: Crohns disease- MC site-terminal ileum with rectal sparing, skip areas It is transmural, hence more of fistula formation More of systemic symptoms, pain, abdominal mass Toxic megacolon - Perforation Intraabdominal abscess, fallopian tube scarring - infertility Intestinal obstruction, massive hemorrhage, malabsorption, severe perianal disease Cobblestoning on endoscope Response to antibiotics and recurrence after surgery ASCAanti-saccharomyces cerevisiae antibody-positive Treatment - Antibiotics, corticosteroids, sulfasalazine, mercaptopurine, azathioprine, methotrexate. cyclosporine, tacrolimus Anti-TNF: Infliximab, adalimumab. certolizumab pegol Anti-integrin: Natalizumab Risk of Ca increases with duration severity of the disease See the following table 