<prompt> All of the following genes may be involved in development of carcinoma of colon ExceptAPCBeta-CateninK-rasMismatch Repair Genes  <response>: .Detection of mutations in congenital conditions like von - Hippel - Lindau disease vHL gene; haemochromatosis HFE gene; colorectal carcinomaAPC gene.Familial gastric cancer in associated with mutation of e-cadherin gene 90 risk. It causes hereditary diffuse gastric cancer. Relatives of such family show mutation of this gene. Whether prophylactic total gastrectomy is needed or not in these high risk individuals is a debate. ref:SRB;s manual of surgery ,ed 3,pg no 777 