<prompt> In which of the following condition normal anion gap metabolic acidosis is seen?DiarrhoeaRenal failureLactic acidosisDiabetic ketoacidosis  <response>: Alkali can be lost from the gastrointestinal tract in diarrhea or from the kidneys renal tubular acidosis, A. In these disorders, reciprocal changes in and result in a normal anion gap. In pure non-AG acidosis, therefore, the increase in above the normal value approximates the decrease in . Causes of non anion gap acidosis: Gastrointestinal bicarbonate loss Diarrhea External pancreatic or small-bowel drainage Ureterosigmoidostomy, jejunal loop, ileal loop Drugs Calcium chloride acidifying agent Magnesium sulfate diarrhea Cholestyramine bile acid diarrhea Renal acidosis Hypokalemia Hyperkalemia Drug-induced hyperkalemia with renal insufficiency Potassium-sparing diuretics amiloride, triamterene, spironolactone Trimethoprim ACEIs and ARBs Nonsteroidal anti-inflammatory drugs Other Loss of potential bicarbonate: ketosis with ketone excretion Cation exchange resins Ref: DuBose, T.D. 2012. Chapter 47. Acidosis and Alkalosis. In D.L. Longo, A.S. Fauci, D.L. Kasper, S.L. Hauser, J.L. Jameson, J. Loscalzo Eds, Harrisons Principles of Internal Medicine, 18e. 