<prompt> A 70 - year- old man was administered penicilline intravenously. Within 5 minutes, he developed genralised urticaria, swelling of lips, hypotension and bronchospasm. The first choice of treatment is to administer:chlorphenitramine inj.Epinephrine inj.High dose hydrocortisone tabletnebulised salbutamol  <response>: Ans. is b i.e. epinephrine injection Urticaria, swelling of lips, hypotension and bronchospasm within 5 minutes of i.v penicillin suggests anaphylactic reaction. Its a major problem with the use of penicillin.The tt of choice for anaphylaxis is i.v epinephrine. 