<prompt> A teenager girl with moderate acne is also complaining of irregular menses. Drug of choice with be-Oral jsotretinonOral acitretinOral minocyclineCyproterone acetate  <response>: In Acne with associated endocrinological abnormalities like polycystic ovarian syndrome PCOS manifests with obesity, hirsutism, androgenetic alopecia and acne. Oestrogens and antiandrogenscyproterone acetate, spirono lactone, flutamide and agents designed to inhibit the endogenous production of androgens by the ovaryoral contraceptives and gonadotropin releasing agonists or adrenal glandlow dose glucocoicoids are used Reference Harrison20th edition pg 1206 