<prompt> Which of the following clinical situations is associated with an increase in predominantly conjugated direct bilirubin?Physiologic jaundice of the neonateKernicterus Following Rhesus IncompatibilityGilbes SyndromePancreatic head tumor  <response>: Of the conditions listed, only pancreatic head tumors are associated with an increase in conjugated direct bilirubin obstructive jaundice. Increased levels of unconjugated direct bilirubin result from hemolysis over liver defects that impair uptake or conjugation mechanism in liver cells Gilbes syndrome, Crigler- Najjar syndrome positive. Unconjugated bilirubin may cross the immature blood brain Barrier of the newborn and cause Kernicterus. The physiologic jaundice of the newborn observed during the first week of bih is usually mild and due to relatively immature liver conjugation. Ref: Cothren C., Biffl W.L., Moore E.E. 2010. Chapter 7. Trauma. In F.C. Brunicardi, D.K. Andersen, T.R. Billiar, D.L. Dunn, J.G. Hunter, J.B. Matthews, R.E. Pollock Eds, Schwazs Principles of Surgery, 9e. 