<prompt> Epitheliod granuloma is caused byNeutrophilsCytotoxic T cellsHelper T cellsNK cells  <response>: ref Robbins 7e p 83 CD 4 hepler cells are involved in granuloma formation as it secreted lFN - gamma, IL 2 ,IL 12 Histiocytes specifically macrophages are the cells that define a granuloma. They often, but not invariably, fuse to form multinucleated giant cells Langhans giant cell. The macrophages in granulomas are often referred to as epithelioid. 