<prompt> A PATIENT ON LITHIUM THERAPY DEVELOPED HTN,HE WAS STAED ON THIAZIDES FOR HYPEENSION .AFTER FEW DAYS HE DEVELOPED COARSE TREMORS AND OTHER SYMPTOMS SUGGESTIVE OF LITHIUM TOXICITY .EXPLAIN THE LIKELY MECHANISM ::THIAZIDE INHIBIT METABOLISM OF LITHIUMTHIAZIDE AXT AS AN ADD ON DRUG TO LITHIUMTHIAZIDE INCREASE THE TUBULAR REABSORPTION OF LiTHIAZIDE CAUSE LOSS OF WATER THERBY INCREASES Li LEVELS  <response>: DRUG INTERACTION OF LITHIUM : THIAZIDE DIURETICS INCREASE THE LITHIUM TOXICITY LOOP DIURETICS AND K SPARING DIURETICS -- NORMAL OR INC. LITHIUM OSMOTIC DIURETICS AND CARBONIC ANHYDRASE INHIBITORS WILL DECREASE THE LITHIUM LEVELS. REF : KD TRIPATHI 8TH ED 