<prompt> Which is true hermaphroditism?45 X045X04646XX46XY47XY47XX  <response>: Ref. The Short Textbook of Pediatrics. Pg 749 HermaphroditismTrue hermaphroditism is a genetic condition in which affected individuals have both mature ovarian and testicular tissue. The entity is due to chromosomal and genetic cause .Both the testis and the ovarian tissue are present in an individual and in different combinations .Ovotestis on each side commonestTestis on one side ,ovary on other .Testis or ovary on one side and ovotestis on the other .It is probable that fertilisation by a sperm carrying one X chromosome , which contains some male determinant material from Y gives rise to this condition .The common presentation is ambiguity of external genitalia .The internal structure depends on the degree of differentiation of associated gonad on that side .75 develop gynecomastia and nearly 50 menstruateINVESTIGATIONS :Sex chromatin is usually positiveKaryotype is usually 46 XX70 ,rest are 46 XY and rarely mosaic XXXYConfirmation is done by gonadal biopsy 