<prompt> Enzyme does not act byForming non-covalent interactionsCatalyzing the reactionIncreasing activation energyIncreasing the rate of reaction  <response>: Enzyme decreases the activation energy thus they increase the rate of reaction. Mostly in Enzyme-Substrate ES interactions, non covalent interactions are formed Hydrogen, Hydrophobic Ionic bonds. Gibbs Free Energy graph for enzyme catalyzed and enzyme uncatalyzed reaction. On X- axis, reaction progress taken i.e. S getting conveed to P. For any spontaneous reaction, S has more free energy as compared to P. For S to be conveed to P, first S has to acquire Activation energy DG uncatalyzed and reach high energy state Transition state. Only then it can be conveed to P. 