<prompt> All of the following statements are true about sickle cell disease EXCEPT:Patient may require frequent blood transfusionsAcute infection is the most common cause of moality before 3 years of ageThere is positive correlation between concentration of HbS and polymerisation of HbSPatient presents early in life before 6 months of life  <response>: - Patients of Sickle cell anemia rarely presents before 6 months age as abundance of HbF inhibits polymerisation of HbS. CLINICAL FEATURES OF SICKLE CELL ANEMIA: Hand foot syndrome dactylitis of bones of hands, feet Priapism erectile dysfunction Stroke retinopathy- loss of visual acuity blindness Auto splenectomy dt splenic INFARCTS Spleen becomes non palpable Chronic hemolysis - pt may require frequent blood transfusions Renal Involvement- papillary necrosis hyposthenuria cardiomegaly Infections mainly by encapsulated bacteria . - Fever in a child with sickle cell anemia is a medical emergency, require prompt medical evaluation and delivery of antibiotics because of increased risk of bacterial infection and subsequent high moality rate. - Positive correlation is seen bw concentration of HbS polymerization of HbS 