<prompt> True about Dyskeratosis congenita -a Pancytopeniab Nail dystrophyc Hyperkeratosisd X linkede Leukoplakiaabcdbcdeacdeabde  <response>: Dyskeratosis congenitaIt is characterised by mucous membrane leukoplakia, dystrophic nails, reticular hyperpigmentation and the development of aplastic anemia during chidhood.The X-linked variety is due to mutations in the DKC1 dyskeratin gene; the more unusual autosomal dominant type is due to the muatation in hTERC, which encodes an RNA template, and hTERT, which encodes the catalytic reverse transcriptase, telomerase; these gene products cooperate in a repair complex to maintain telomere length.Clinical features associated with dyskeratosis congenita are :-Skin pigmentary abnormalities Nail dystrophy LeukoplakiaEpiphora Cognitivedevelpomemt delayPulmonay diseaseDental carriestooth loss Esophageal strictureHair lossgrey hair sparse eyelashes Hyperhydrosis Intrauterine growth retardation 