<prompt> pKa of lidocaine:8.18.97.87.6  <response>: Lidocaine hydrochloride is very soluble in water and alcohol and soluble in chloroform, but it is insoluble in ether. Lidocaine hydrochloride has a pKa of 7.86. Gebauer et al. developed a method for the study of lidocaine and oxycodone stability in a rectal gel.The dissociation constants pKa for popular local anesthetics used in dentistry are:Mepivacaine 7.6Etidocaine 7.7Lidocaine 7.9Prilocaine 7.9Bupivacaine 8.1Tetracaine 8.5Procaine 9.1Ref: Monheims Local anesthesia 1st ed page no 130 