<prompt> A patient of glaucoma with bronchial asthma presents to the emergency with status asthamaticus, causative agent might have. beenPilocarpine eye dropTimolol eye dropBetaxolol eye dropLevobunolol eye drop  <response>: B i.e. Timolol eye drop B2 receptors are responsible for bronchodialation, therefore blocking B2 would aggravate asthma and Timolol is nonselective beta blocker i.e. blocks B1 B2 both Topical nonselective 0 blockers e.g. timolol are contraindicated in asthma Q, COPD, CHF, sinus bradycardia AV blocks where as selective pi blockers e.g. betaxolol are CI in sinus bradycardia atrioventricular blocks only. 