<prompt> True statement regarding Hirschsprungs disease?Giant ganglia are presentMucosa is involved and show foldingsManometry excludes the diseaseRectal biopsy is contraindicated in infants  <response>: Ans. is c i.e., Manometry excludes the diagnosis o Anorectal manometry is a useful screening procedure for the diagnosis of Hirschsprungs disease. A normal response in course of manometric evaluation precludes diagnosis of Hirschsprungs disease. o However the confirmation of diagnosis in case of Hirschsprungs disease is done by rectal biopsy. 