<prompt> The development of resistance to conventional treatment has led WHO to recommned the use of combination therapies containing aemisinin derivative aemisinin-based combination therapies also known as ACTs. All of the following combination therapies are recommended if such resistance is suspected, except -Aemether plus lumefantrineAesunate plus quinineAesunate plus pyrimethamine-sulfadoxineAesunate plus mefloquine  <response>: Ans. is b i.e. Aesunate plus quinine The WHO recommended ACTs aemisinin-based combination therapies o Aemether lumefantrine o Aesunate sulfadoxine-pyrimethamine o Aesunate amodiaquine o Aesunate mefloquine o Dihydroaemisinin piperaquine. 