<prompt> Calculate the loading dose of a drug whose systemic bioavailability will be 20, Vd-200L and target concentration is 5gmL1g5g12.5g25g  <response>: In pharmacokinetics, a loading dose is an initial higher dose of a drug that may be given at the beginning of a course of treatment before dropping down to a lower maintenance dose Loading dose- 1000205 Ref: KD tripathi 8th ed 