<prompt> Latest most recent oral direct thrombin inhibitor is -XimelagatranIndraparinuxDabigatranFondaparinux  <response>: Ans is c i.e. Dabigatran o Ximelagatran was the first oral direct thrombin inhibitor approved; however, it was subsequently withdrawn from the market because of repos of liver failure. o Recently a new oral direct inhibitor, dabigatran, was approved for use in Europe for prevention of various thromboembolism in patients who have undergone hip or knee replacement surgery. 