<prompt> Intractable seizure in a 7-day-old child with skin rash, Increased ammonia and lactate can be diagnosed asOrganic acidemiaPhenylketonuriaUrea cycle anomalyME LAS with lactic acidosis  <response>: Mutation in mitochondrial DNA, result in disease 1.Mitochondrial myopathies 2.MERRF syndrome - myoclonus epilepsy with ragged red fibers 3.MELAs syndrome - mitochondrial encephalomyopathy with lactate acidosis and stroke like pisodes, Intermittent vomiting, proximal muscles weakness 4.LHONLeber hereditary optic neuropathy-acure or subacute loss vision in men around the age of 20 5.K. SS - Kearns - Sayre syndrome - progressiwe external ophthalmoplegia, pigmentary retinopathy and cardiac conduction defects presenting in childhood. Organic acidemias - The intermediate metabolitess are all organic acids and deficiency of any degrading enzymes except transaminases, causes acidosis, In such msvance the organic acids before the enzymatic block accumulate 