<prompt> Indomethacin reduce the diuretic action of furosemide byPreventing prostaglandin mediated heamodynamic actionsBlockade of furosemide action in loop of henleEnhancing water reabsorption in distal tubuleIncreasing aldosterone secretion  <response>: NSAIDS inhibit specifically PGE2, PGI2 synthesis in renal tubules effecting the hemodynamic changes done by Prostaglandins for water, sodium reabsorption Ref: katzung 12th ed, Autocoids. 