<prompt> Neostigmine antagonizes non depolarising blockade by all of the following mechanism exceptDecreasing the breakdown of acetyl choline at the motor end platePreventing the KeffluxIncreasing the release of acetyl choline at the motor end plateDepolarization at the motor end plate  <response>: Refer Katzung 10e p 436 Neostigmine is an anti cholinerasterase. It inhibits the breakdown of ACh at the mother end plate This results in increased activity of ACh that causes depolarization of motor end plate by opening Nachannels . It posseses some direct agonistic activating on NM receptors resulting in depolarization 