<prompt> All of the following statements about Aprepitant are true, except:Agonist at Neurokinin receptor NK1Crosses the blood brain barrierMetabolized by CyP3A4 pathwayAmeliorates nausea and vomiting of chemotherapy  <response>: Ans is a i.e. Agonist at Neurokinin receptor NK1 Aprepitant is an antiemetic substance that belongs to a class of drugs called substance P antagonists. o The compound mediates its effect by blocking the neurokinim 1 NK1 receptor. o Aprepitant crosses the blood brain barrier. o Aprepitant is used for chemotherapy induced nausea vomiting CINY, and post- operative nausea vomiting PONV. o After absorption aprepitant is bound extensively to plasma proteins 95; it is metabolized avidly, primarily by hepatic CYP 3A4 and is excreted in the stools. 