<prompt> Trastuzumab is directed againstHuman epidermal growth factor receptor 2Vascular endothelial growth factor APlatelet derived growth factorFibroblast growth factor 23  <response>: Trastuzumab is a humanized monoclonal antibody directed against the extracellular domain of the human epidermal growth factor receptor -2 HER-2 surface receptor and is effective treatment for HER-2-positive breast cancer Ref: Sabiston 20e, page: 840 