<prompt> Detection rate of down syndrome with first trimester screening with NT, PAPP-A and hCG is64-7080-8494-9699  <response>: Selected Down Syndrome Screening Strategies and Their Detection RateScreening testDetection rateQuadruple screen 80-82First trimester screenNT alone64-70NT, hCG, PAPP-A80-84Integrated screening94-96Sequential screeningStepwise92Contingent91Cell-free DNA91Ref: Williams Obstetrics; 25th edition 