<prompt> At physiological pH DNA is ?AcidicNegatively chargedAmphipathicAll of the above  <response>: Ans. is d i.e., All of the above DNA is amphipathic Amphipathic molecule is one which contains both polar hydrophilic and nonpolar hydrophobic regions in its structure, i.e. the pa of molecule is water soluble and pa is water insoluble. In DNA helix Hydrophilic polar deoxyribose-phosphate of each chain is on outside of molecule. Hydrophobic nonpolar bases are stacked in. Thus DNA is regarded as amphipathic in nature. DNA is negatively charged and acidic Phosphate group lies on outside of molecule of DNA. Each phosphate group has a negative charge at physiological pH, making DNA a negatively charge anion at physilogical pH. Histones are strongly cationic and can bind non-specifically to strongly aniomic DNA Harper At physiological pH DNA is negatively charged, and is associated with positively charged basic histones Ronald Hofmann. o Anionic molecules are acidic in nature. 