<prompt> Which of the following pathogenic mechanism is involved in the generation of sarcoidosis:Intra-alveolar and interstitial accumulation of CD4 T cellsIncreased levels of T cell-derived TH1 cytokines such as IL-2 and IFN-gIncreased levels of cytokines in the local environment IL-8, TNFAll of the above  <response>: Pathogenesis of sarcoidosis: Unidentified antigen - CD4 helper T cells - Non-necrotizing epithelioid granuloma Intra-alveolar and interstitial accumulation of CD4 helper T-cells. Increase in Th1 cytokines such as IL-2 and IFN-g, resulting in T cell proliferation and macrophage activation, respectively Increase in several cytokines in the local environment IL-8, TNF, macrophage inflammatory protein-1a that or recruitment of additional T cells and monocytes and contribute to the formation of granulomas. Significant elevation of angiotensin-conveing enzyme ACE in serum derived from activated macrophages. Impaired dendritic cell function. 