<prompt> In Tuberous sclerosis all are seen except:EpendymomaAdenoma sebaceumGiant cell astrocytomaSub ependymal nodules  <response>: Ans. A. EpendymomaTuberous sclerosis is a neurocutaneous syndrome. Neurologic findings: Tubers and the presence of subependymal nodules SENs and subependymal giant cell astrocytomas SEGAs Cutaneous findings: The best-known cutaneous manifestation of TSC is adenoma sebaceum, which often does not appear until late childhood or early adolescence Cardiac findings: Cardiac involvement is usually maximal at birth or early in life; mostly rhabdomyomas. Ophthalmic findings: some these lesions are actually retinal astrocytomas that tend to become calcified over time Renal findings: Renal manifestations of TSC are the second most common clinical feature; 4 types of lesions can occur: autosomal dominant polycystic kidney disease lesions, isolated renal cysts, angiomyolipoma AMLs, and renal cell carcinomas Dental findings: Pitting of the dental enamel is invariably present in the permanent teeth of patients with TSC; gingival fibromas, mixed dentition primary and permanent teeth, and in 3 of children with only primary teeth Gastrointestinal findings: Hamartomas and polyposis of the stomach, intestine, and colon may occur Hepatic findings: Hepatic cysts and hepatic AMLs, typically asymptomatic and non-progressive Skeletal findings: Sclerotic and hypertrophic lesions of bone 