<prompt> Anti-Saccharomyces cerevisiae antibodies are seen in?Crohns diseaseSclerodermaSLESjogrens syndrome  <response>: ANSWER: A Crohns diseaseREF: Harrisons Internal Medicine 17m edition chapter 289. Inflammatory Bowel DiseaseAnti-Saccharomyces cerevisiae antibodies ASCA, along with perinuclear antineutrophil cytoplasmic antibodies pANCA, are among the two most useful and often discriminating markers for colitis. ASCA tends to recognize Crohns disease more frequently, whereas pANCA tend to recognize ulcerative colitis 