<prompt> Which anaesthetic modality is to be avoided in sickle cell disease?General AnaesthesiaBrachial Plexus BlockIntravenous Regional AnaesthesiaSpinal Anaesthesia  <response>: IV regional anaesthesia is useful for rapid anesthetization of an extremity upper or lower. A rubber bandage is used to force the blood out of the limb and a tourniquet is applied to prevent the re-entry of blood.This causes risk of massive hemolysis due to low oxygen tension or hemolytic crisis due to low blood flow.All the other given methods above don;t carry that risk. 