<prompt> Statins are given at night because -HMG-CoA reductase activity is maximum in midnightStatins are maximally absorbed in nightStatins have more potency in nightConvenient for patient to remember  <response>: Ans. is a i.e., HMG-CoA reductase activity is maximum in midnight o Because HMG-CoA reductase activity is maximum at midnight, all statins are administered at bed time to obtain maximum effectiveness. However, this is not necessary for atorvastatin and rosuvastatin, which have long plasma t12. 