<prompt> Which of the following are alkylating agents:CyclophosphamideIfosfamidePaclitaxelMethotrexate  <response>: ALKYLATI NG AGE NTS These compounds produce highly reactive carbonium ion intermediates which transfer alkyl groups to cellular macromolecules by forming covalent bonds. The position 7 of guanine residues in DNA is especially susceptible, but other molecular sites are also involved. Alkylation results in cross linking abnormal base pairing scission of DNA strand. Cross linking of nucleic acids with proteins can also take place. Mechlorethamine Mustine HCL Cyclophosphamide Ifosfamide Chlorambucil Melphalan Thio-TEPA Busulfan Nitrosoureas DacarbazineDTIC ESSENTIALS OF MEDICAL PHARMACOLOGY K.D.TRIPATHI SIXTH EDITION PAGE NO:821,822 