<prompt> Taysachs disease is due to the deficiency ofHexosaminidaseLysozomal enzymeGalactocerebrosideCeramidase  <response>: A Hexosaminidase Tay-Sachs disease TSD, GM2 gangliosidosis, Hexosaminidase A deficiency or Sphingolipidosis is a genetic disorder, fatal in its most common variant known as Infantile Tay-Sachs disease. TSD is inherited in an autosomal recessive pattern. Disease occurs when harmful quantities of a fatty acid derivative called a ganglioside accumulate in the nerve cells of the brain. Gangliosides are lipids, components of cellular membranes, and the ganglioside GM2, implicated in Tay-Sachs disease, is especially common in the nervous tissue of the brain. 