<prompt> Deficiency of the Intrinsic factor of Castle causes-Megaloblastic anemiaPernicious anemiaCooleys anemiaAplastic anemia  <response>: Pernicious anemia is a chronic disease resulting from deficiency of Intrinsic factor leading to impaired absorption of Vitamin B12. Megaloblastic anemia is due to deficiency of Cobalaminfolate. Reference: Atlas and text of Hematology, 3rd edition, pg:102. Exam preparatory manual for UGs by Ramdas Nayak page no: 259 