<prompt> Most common side effect of haloperidol -HypotensionAkathasiaDryness of mouthTic disorder  <response>: Ans. is b i.e., Akathasiao 75 of patients experience extrapyramidal symptoms Akathisia, Parkinsonism, acute muscular dystonia with all classical typical antipsychotics.o Haloperidol is a typical antipsychotic.Important side effects of antipsychoticsI Based on pharmacological actions dose dependent1. CNSo Drowsiness, lethargy, mental confusion.o Increased appetite and weight gain due to H1 and 5HT2 blockade. It is least with haloperidol.o Seizures - with clozapine and olanzapine.2. CVSo Postural hypotension, palpitation, inhibition of ejaculation due to a blockade - maximum with chlorpromazine, thioridazine and clozapine - Goodman Gilmen 11the p. 463o Minimum hypotension - Aripiprazole - Goodman Gilmen llthep. 464.o QTprolongation and cardiac arrhythmia - Thioridazine, pimozide and ziprasidone.3. Anticholinergic side effects.o Maximum with thioridazine.o Clozapine causes hypersalivation despite anticholinergic property.4. Endocrineo Hyperprolactinemia is common with typical neuroleptics amongst atypical neuroleptics risperidone causes hyperprolactinemia - Amenorrhea, galactorrhea, infertility, impotence, gynaecomastia.o Worening of diabetes - Clozapine, olanzapine.5. Extrapyramidal disturbanceso These are major dose limiting side effects.o Maximum with haloperidol.o Least with clozapine among all antipsychotics.o Amongst typical antipsychotics, least with thioridazine.o Amongst atypical antipsychotic, resperidone has maximum tendency to cause extrapyramidal disturbances.o Different syndromes are :Parkinsonism, Acute muscular dystonia, Akathisia, Malignant neuroleptic syndrome, Tardive dyskinesia, Rabbit syndrome.II. Other side effects.o Corneal and lenticular deposites - chlorpromazine - Katzung 10the p. 467.o Retinal deposits - Thioridazine - Katzung 10the p. 467.o Blue pigmentation of exposed skin - Thioridazine,o Agranulocytosis - Clozapine.Because of the risk of agranulocytosis, patients, recieving clozapine must have weekly blood counts for the first 6 months and every 3 weeks thereafter.o Myocarditis - Clozapine.o Hypersensitivity - Cholestatic jaundice, skin rash, urticaria, contact dermatitis, photosensitivity,o Cataract - Quetiapine. 