<prompt> Person had severe pruritis while taking hot shower and presents with deep vein thrombosis. He also had JAK 2 mutation and hypeension. Which of the following is the most likely diagnosis of this patient?MyelofibrosisPolycythemia VeraCMLAML  <response>: The presence of JAK2 mutation indicates that it is an example of Myeloproliferative disorder. Polycythemia vera is strongly associated with activating point mutations in the tyrosine kinase JAK2. Clinical features: Headache, dizziness, hypeension,Intense pruritus and peptic ulceration possibly resulting from the release of histamine from basophils. Hot showers AQUAGENIC PRURITUS will result in degranulation of the basophils thus releasing histamines. 