<prompt> Which of the following is an indication for the use of folinic acid?Prophylaxis of neural tube defects in the offspring of women receiving anticonvulsant medicationsCounteracting toxicity of high dose methotrexate therapyPernicious anemiaAnemia associated with renal failure  <response>: Prophylaxis of neural tube defects require treatment with folic acid. Methotrexate toxicity can be prevented by 5-formyltetrahydrofolate folinic acid. Pernicious anemia requires the therapy with vitamin B12. Anemia associated with chronic renal failure is treated with erythropoietin. 