<prompt> Brushfield spot in iris is seen in-NeurofibromatosisDown syndromeTtoberous sclerosisToxoplasmosis  <response>: Brushfield spots are small, white or grayishbrown spots on the periphery of the iris due to aggregation of connective tissue. Seen in Down syndrome patients of European descent. Other ocular features in Down syndrome: Epicanthal folds Mongoloid slanting of eye Myopia Keratoconus Esotropia Congenital Cataract Blepharitis In Neurofibromatosis, Lisch nodules are seen. 