<prompt> Granuloma formation is seen with which hypersensitivity reaction?TypelType2Type3Type4  <response>: Ans d: Ref: ROBBINS 7th edition- 217Cell mediated or Delayed type hypersensitivity Involve activated T cells. It includes:a Delayed hypersensitivityMajor mechanism of defense against various intracellular pathogens Characteristic lesion is granuloma -Activated macrophagesepitheliod cells surrounded by a collar of lymphocytes giant cellsb T cell mediated cytotoxicityMechanism: Cytotoxic T cells kill virus infected cells of tumor cells Eg of Type IV HS Tuberculin test, lepromin test, Frei test, Fairleys test Typel lepra reaction Contact dermatitis Temporal arteritis Jones mote reaction cutaneous basophilic HSN 