<prompt> What is the effect of progesterone on lipids normally?Lowers LDL, increases HDLLowers HDL and LDLLowers HDL and increases LDLIncreases LDL and HDL  <response>: Progesterone stimulates lipoprotein lipase activity and seems to enhance fat deposition. Progesterone and analogs such as MPA have been repoed to increase LDL and cause either no effects or modest reductions in serum HDL levels. Progesterone itself increases basal insulin levels and the rise in insulin after carbohydrate ingestion, but it does not normally alter glucose tolerance. Ref: Levin E.R., Hammes S.R. 2011. Chapter 40. Estrogens and Progestins. In L.L. Brunton, B.A. Chabner, B.C. Knollmann Eds, Goodman Gilmans The Pharmacological Basis of Therapeutics, 12e. 