<prompt> PV examation is contraindcated inPlacenta previaCord prolapsedRupture membraneCPD  <response>: Placenta previa 244- Dutta 7thPLACENTA PREVIAVaginal examination must not be done outside the operation theater in the hospital, as it can provide further separation of placenta with torrential hemorrhage and may be fatal. It should only be done prior to termination of pregnancy in the operation theater under anesthesia, keeping everthing ready for casarean section The regimen used for expectant management of placenta previa is- Macafee Johnson regimenExpectant Management of placenta previa Rest Absolute bed rest for up to 72 hours after bleeding stops Careful monitoring clinical Laboratory USG every 2-3 weeks Blood transfusion and Hematinics maintain Hb atleast 10 gdl and Hematocrit of 30 Antenatal steroids for foetal maturity Between 24-34 weeks of gestation Anti D immunoglobulin to all RH negative womenUse of Tocolysis controversial May be justified in selected cases but their use is not supported by strong evidenceCervical Encirclage - Not currently recommended insufficient evidence First sign of magnesium toxicity is loss of deep tendon reflex Bile acids represent best markers for intrahepatic cholestasis of pregnancy Ursodiol uricodeoxycholic acid is treatment of choice for Intrahepatic cholestases in pregnancy Methotrexate is absolutely contraindicated during pregnancy class xand lactation due to its potential for spontaneous abortion and teratogenecity Transplacental transmission is rare with both Herpes simplex and Hepatitis B 