<prompt> Amoxicillin clavulanic acid is active against the following organisms EXCEPT :Methicillin resistant Staph. aureusPenicillinase producing Staph. aureusPenicillinase producing N. gonorrhoeaeβ-lactamase producing E. coli  <response>: Staphylococcus aureus develops resistance to methicillin by acquiring altered penicillin-binding proteins that have low affinity. No Beta-lactam antibiotic is effective against MRSA.Clavulanic acid is an inhibitor of β-lactamase. It can restore the sensitivity of penicillins against the organisms who have developed penicillinases. 