<prompt> Practically all antineoplastic drugs can produce the following toxic effects exceptDepression of leucocyte countCardiomyopathyMucositisOligozoospermia  <response>: GENERAL TOXICITY OF CYTOTOXIC DRUGS 1 Bonemarrow :- Depression of bone marrow results in granulocytopenia, agranulocytosis, thrombocytopenia, aplastic anaemia. Infections and bleeding are the usual complications. 2 Lymphoreticular tissue Lymphocytopenia and inhibition of lymphocyte function results in suppression of cell mediated as well as humoral immunity. Because of action 1 and 2 damage to epithelial surfaces, the host defence mechanisms are broken down - susceptibility to all infections is increased. 3GIT:- Diarrhoea, shedding of mucosa, haemorrhages occur due to decrease in the rate of renewal of the gastrointestinal mucous lining. Drugs that prominently cause mucositis are-- bleomycin, actinomycin D, daunorubicin, doxorubicin, fluorouracil and methotrexate. Nausea and vomiting are prominent with many cytotoxic drugs. This is due to direct stimulation of CTZ by the drug. 4Gonads:- Inhibition of gonadal cells causes oligozoospermia and impotence in males; inhibition of ovulation and amenorrhoea are common in females. Ref:- kd tripathi; pg num:-859 