<prompt> Neural tube defects are associated with which drugs?EthosuximideValproic acidLamotrigineTopiramate  <response>: Ans. is b i.e., Valproic acid Adverse effects of Na valproate Anorexia, vomiting, loose motions and heart burn are common but mild. Dose related side effects are Drowsiness, ataxia, tumors. Alopecia, curling of hair, weight gain and increased bleeding tendency. Rashes and thrombocytopenia are infrequent hypersensitivity phenomenon. Fulminant hepatitis occurs rarely in children especially below 3 years of age. Pancreatitis is also reported in some cases. Used in pregnancy, it has produced spina bifida and other neural tube defects in the offspring and should be avoided. Young girls on Na valproate sometimes may show features of PCOD and menstrual irregularities. 