<prompt> EMA-CO regime of chemotherapy is used in the treatment of?Gestational trophoblastic neoplasiaMalignant Ovarian germ cell tumorEndometrial carcinomaCA cervix  <response>: Ans. A. Gestational trophoblastic neoplasiaPatients with high-risk tumors high beta-hCG levels, disease presenting 4 months after antecedent pregnancy, brain or liver metastasis, or failure of single-agent methotrexate are initially treated with combination chemotherapy. EMA-CO a cyclic non-cross-resistant combination of etoposide, methotrexate, and dactinomycin alternating with cyclophosphamide and vincristine; cisplatin, bleomycin, and vinblastine; and cisplatin, etoposide, and bleomycin are effective regimens. EMA-CO is now the regimen of choice for patients with high-risk disease because of excellent survival rates 80 and less toxicity. 