<prompt> What is the significance of increased nuchal translucency at 14 weeks of gestation?Oesophageal atresiaForegut duplication cystDowns syndrome Trisomy 21Edwards syndrome Trisomy 18  <response>: Nuchal translucencyNT is a term used to describe a sonolucent area in the nuchal region back of the neck of the fetus and is typically observed in the first trimester 10-14weeks. Increased NT refers to NT measurement of greater than 2.5mm. One third of fetus with increased nuchal translucency will have a chromosome abnormality, and 12 of these are Down syndrome. Ref: Williams Obstetrics 23rd Edition Chapter 13; Obstetrics, Gynecology Infeility By R Rajan Page 225-6; Textbook of Obstetrics By D. C Dutta, 6th Edition, Page 107. 