<prompt> Which of the following antiglaucoma medications are not safe in infantsTimololbrimonidineLatanoprostDorzolamide  <response>: Apraclonidine and brimonidine can cross blood brain barrier and can cause CNS depression and Apnea in neonates. therefore these are contraindicated in children less than 2 years of age Refer Goodman and Gilman 12e p1788,kdt 6e 168 