<prompt> Proton pump inhibitors are most effective when they are given -After mealsSholy before mealsAlong with H2 blockersDuring prolonged fasting periods  <response>: Ans. is b i.e., Sholy before meals o Bioavailibility of all PPIs is reduced by food; they should be taken in empty stomach, followed 1 hour later by a meal to activate 1-1 ATPase and make it more susceptible to the PPI. o PPIs should be administered approximately 1 hour before a meal usually breakfast so that the peak serum concentration coincides with the maximal activity of proton pump secretion. 