<prompt> PPV23 is not recommended in?Pts with Sickle cell diseaseImmunocompromised patientsPost-splenectomyPts with Diabetes mellitus  <response>: Polysaccharide non-conjugate vaccine PPV 23 contains capsular antigens of 23 serotypes. Dose: 0.5 ml , route: IM preferred, can be given SC also Children under 2 years of age immunocompromised individuals do not respond well to the vaccine. Pneumococcal conjugate vaccine PCV7- for use in children 23 months and younger. PCV 23 recommended for selected groups like: Children above 2 yrs of age and adults. Post-splenectomy Sickle-cell disease pts. Chronic diseases of hea, lung, liver or kidney. Diabetes mellitus Alcoholics Generalized malignancies, organ transplants etc. 