<prompt> Which apolipoprotein is responsible for Alzeihmers diseaseAPOE1APOE2APOE3APOE4  <response>: Familial AD and Apo-E4 gene: There is an association between patients possessing the apo E4 allele and the incidence of Alzheimer disease. Apparently, apo E4 binds more avidly to beta-amyloid found in neuritic plaques. Genes identified with AD are that coding for APP, presenilin-1 chromosome 14, presenilin-2 chromosome 1 or AD3 chromosome 14 or AD4 chromosome 1, and Apo-E4 gene chromosome 19. The presence of Apo-E4 gene is the major risk factor for AD. Apo-E2 gene reduces the risk of AD. Ref:- Harper 30e; pg num:- 275 