<prompt> Ophthalmia neonatorum within first 48 hours of birth is caused byAdenovirusNeiserria gonorhoeaeCandida albicansChlamydia trachomatis  <response>: Ans. b Neisseria gonorrheae Ref: Parsons, 18th ed140DIFFERENTIAL DIAGNOSIS OF NEONATAL CONJUNCTIVITIS OPHTHALMIA NEONATORUMCauseOnsetFindingsCytologylab tests1Toxic AgNO3- Silver nitrate Credes prophylaxisWithin hoursHyperemiaSlight watery to mucoid discharge. Negative culture2Gonococci gonococcal conjunctivitis2nd-4th day of lifeAcute purulent conjunctivitisIntracellular gram-negative diplococci.Positive culture on blood and chocolate agar3Other bacteria Pseudomonas aeruginosa, Staphylococcus aureus, Streptococcus pneumoniae; Haemophilus4th-5th day of lifeMucopurulent conjunctivitisCulture on bloodagar4Chlamydia inclusion conjunctMtis... most common5th-14th day of lifeMucopurulent conjunctivitisGiemsa-positive cytoplasmic inclusion bodies in epithelial cells.Negative culture.5Herpes simplex virus5th-7th day of lifeWatery blepharoconjunctivitis. Corneal involvement.Systemic manifestations.Multinucleated gaint cells, cytoplasmic inclusion bodies.Negative cultureEducational Points:Intact corneal epithelium cannot be penetrated b any organism EXCEPT- Neisseria gonorrhoeae Neisseria meningitides Cornybacterium diphtheriaeConjunctivitis FeaturesAcute mucopurulent conjunctivitis Staph, is commonest causative organism.Ophthalmia neonatorum Chlamydia is most common causative organism 7-10 days Presents at birthin a hour of birth Chemical Treatment is Credes prophylaxis with 1 silver nitrateLigneous conjunctivitis Membranous but repeated conjunctivitisAngular conjunctivitis Caused by Moraxella. Treatment is zinc oxideFollicular conjunctivitis Trachoma, drug induced,New Castles conjunctivitis Epidemic keratoconjunctivitis sicca adenovirusAcute herpetic conjunctivitis occurs in young children infected from contagion of carrierVernal conjunctivitis Spring catarrh Bulbar and palpebral conjunctivitis Bilateral and recurrent Ropy discharge Cobble stone palpebral conjunctiva Gaint papilla Horner-Trantas spots Maxwell-Lion sign Pseudogerontoxon Treatment with steroids, acetyl cysteine and topical NSAIDEducational point: Sulphacetamide eye drops used for ophthalmia neonatorum. 