<prompt> Arachidonic acid metabolites are all except:Prostaglandin G2Leukotriene C4ThromboxanesPhospholipase  <response>: The lipid mediators prostaglandins and leukotrienes are produced from arachidonic acid AA present in membrane phospholipids, and stimulate vascular and cellular reactions in acute inflammation. AA derived mediators, also called eicosanoids because they are derived from 20 carbon fatty acids; Greek eicosa 20 These are synthesized by two major classes of enzymes: cyclooxygenases which generate prostaglandins and thromboxanes lipoxygenases which produce leukotrienes and lipoxins Principal actions of Arachidonic acid metabolites in inflammation Action Eicosanoid Vasodilation Prostaglandins PGI2 prostacyclin, PGE1, PGE2, PGD2 Vasoconstriction Thromboxane A2, leukotrienes C4, D4, E4 Increased vascular permeability Leukotrienes C4, D4, E4 Chemotaxis, leukocyte adhesion Leukotrienes B4, HETE hydroxyeicosatetraenoic acid. 