<prompt> Which of the following is a phase II drug metabolism reaction associated with a genetic polymorphismGlucuronidationAcetylationReductionOxidation  <response>: BIOTRANSFORMATION Metabolism Biotransformation reactions can be classified into: aNonsyntheticPhaseIFunctionalization reactions: a functional group is generated or exposed-- metabolite may be active or inactive. b SyntheticConjugation Phase II reactions: an endogenous radical is conjugated to the drug-- metabolite is mostly inactive; except few drugs, e.g. glucuronide conjugate of morphine and sulfate conjugate of minoxidil are active. Acetylation:- Compounds having amino or hydrazine residues are conjugated with the help of acetyl coenzyme-A, e.g. sulfonamides, isoniazid, PAS, dapsone, hydralazine, clonazepam, procainamide. Multiple genes control the N-acetyl transferases NATs, and rate of acetylation shows genetic polymorphism slow and fast acetylators. Ref:- kd tripathi; pg num:-22,24 