<prompt> Which of the following is not a feature of APLA?Haemolytic anemiaFalse positive VDRLThrombocytopeniaDecreased PT with increased APTT  <response>: Antiphospholipid syndrome APS It is an autoantibody-mediated acquired thrombophilia characterized by recurrent aerial or venous thrombosis andor pregnancy morbidity. Catastrophic APS CAPS is defined as a rapidly progressive thromboembolic disease involving simultaneously three or more organs, organ systems, or tissues leading to the corresponding functional defects. Patients with APS often possess antibodies recognizing Treponema pallidum PLcholesterol complexes, which are detected as biologic false-positive serologic tests for syphilis BFP-STS and Venereal Disease Research Laboratory VDRL tests. Lupus anticoagulant LA Antibodies recognize b2GPI or prothrombin PT and elongate aPTT, implying that they interfere with the generation of thrombin by prothrombin . Prolongation of the clotting times is an in vitro phenomenon, and LA induces thromboses in vivo. Other two antibodies are Antibodies against cardiolipin aCL and Antibodies against b2GPI anti-b2GPI. Clinical Features of Antiphospholipid Syndrome Venous Thrombosis and Related Consequences Deep vein thrombosis Livedo reticularis Pulmonary embolism Superficial thrombophlebitis Thrombosis in various other sites Aerial Thrombosis and Related Consequences Stroke Cardiac valve thickeningdysfunction andor Libman-Sacks vegetations Transient ischemic attack Myocardial ischemia infarction or angina and coronary bypass thrombosis Leg ulcers andor digital gangrene Aerial thrombosis in the extremities Retinal aery thrombosisamaurosis fugax Ischemia of visceral organs or avascular necrosis of bone Multi-infarct dementia Neurologic Manifestations of Unceain Etiology Migraine Epilepsy Chorea Cerebellar ataxia Transverse myelopathy Renal Manifestations Due to Various Reasons Renal AeryRenal VeinGlomerular Thrombosis Fibrous Intima Hyperplasia Osteoaicular Manifestations Ahralgia Ahritis Obstetric Manifestations Referred to the Number of Pregnancies Preeclampsia Eclampsia Fetal Manifestations Referred to the Number of Pregnancies Early fetal loss 10 weeks Late fetal loss 10 weeks Premature bih among the live bihs Hematologic Manifestations Thrombocytopenia Autoimmune hemolytic anemia Ref: Harrison;s Principles of Internal Medicine; 20th edition; Chapter 379 Antiphospholipid Syndrome; Page no: 2135 