<prompt> Metoclopromide -Inhibits cholinergic smooth muscle stimulation in the Gastrointestinal tractIncreases lower esophagial sphinctor pressureStimulates D2 receptorsEnhances colonic motility  <response>: Ans. is b i.e., Increases lower esophageal sphinctor pressure Effects of metoclopramide on GIT Metoclopramide has 5-HT4 agonistic and D2 antagonistic activity in GIT. o These two actions result in enhanced cholinergic smooth muscle stimulation. o Metoclopramide has prominent effect on upper GIT i Increases gastric peristalsis ii Relaxes pylorus and first pa of duodenum iii Tone of lower esophageal sphinctor is increased o Metoclopramide has no or minimal effect on lower GIT -- increases intestinal motility to some extent, but has no action on colonic motility. 