<prompt> Which is Less nephrotoxic?IodixanolDiatrizoateMetrizoateIoxaglate  <response>: Contrast Agents with High Iodine:paicle ratio tends to be less nephrotoxic Iodixanol is Isoosmolar contrast agent , Nonionic Dimer with Iodine :Paicle Ratio of 6:1 and tends to be less nephrotoxic than the other iodinated compounds given here Contrast-induced nephropathy CIN Classically defined as a serum creatinine increase of at least 25 or an absolute increase in serum creatinine of 0.5mgdL after using iodine contrast agent without another clear cause for acute kidney injury within 48-72hrs of Intravenous contrast Markers of CIN Serum Cystatin C levels Neutrophil Gelatinase associated lipocalcinNAGL eGFR60mlmin For prevention- Maintain Hydration 