<prompt> 53-year-old woman presents to her GP for a follow-up visit after having high BP on her last visit. She is again found to be hypeensive and was prescribed hydralazine, a b-blocker, and furosemide. The woman takes no additional prescription or over-the-counter medications. She complains of muscle aches, joint pain, and rash. Physical exam reveals a temp. of 37.7degC 100.0degF and a scaling erythematous rash on her face. The physician orders an autoantibody panel: Antinuclear antibodies ANA: Positive Anti-histone antibodies: Positive What is the most likely diagnosis?Systemic lupus erythematosusHydralazine-induced lupus erythematosusb-blocker-induced systemic lupus erythematosusFurosemide-induced systemic lupus erythematosus  <response>: Rash, ahralgias, and anti-histone antibodies suggest drug-induced systemic lupus erythematosus SLE. 95 of patients develop ahralgias or myalgias or ahritis in SLE Hydralazine is the causative drug in this case. Positive ANA is nonspecific, as there are many conditions, mostly infectious and autoimmune, that show positive ANARIM pattern is specific for SLE. Sensitivity of ANA for drug- induced SLE is 100, so if ANA is negative, drug-induced SLE can be ruled out. Drugs known to induce SLE- procainamide, chlorpromazine, isoniazid, methyldopa, minocycline, penicillamine, and diltiazem. Drug induced lupus is common in whites and has a less female predilection as compared to SLE Hematological abnormalities, kidney and brain involvement are infrequent and anti-dsDNA antibodies are rarely positive 