<prompt> HMG-Co-A Reductase is associated withType 2 DiabetesFamilial HypercholesterolemiaGauchers diseaseAbetalipoproteinemia  <response>: B Familial Hypercholesterolemia HMG-CoA reductase or 3-hydroxy-3-methyl-glutaryl-CoA reductase or HMGR is the first enzyme of the HMG-CoA reductase pathway, the metabolic pathway that produces cholesterol and various other biomolecules. HMG-CoA reductase is a polytopic, transmembrane protein that catalyzes a key step in the mevalonate pathway which is involved in the synthesis of sterols, isoprenoids and other lipids. HMG-CoA reductase is the rate-limiting step in cholesterol synthesis and represents the sole major drug target for contemporary cholesterol-lowering drugs. 