<prompt> Which is the best way to manage a patient present with aspirin poisoningMake urine acidic with NH4G1Make urine alkaline with NaHCO3Treat with N-acetyl cysteineDo gastric lavage  <response>: Ans. b Make urine alkaline with NaHCO3Refi.KDT 6th ed. 16 Aspirin is an acidic drug, it readily crosses any acidic medium. To treat this toxicity, make the urine alkaline with NaHCO3. Now, this acid drug cant be reabsorbed from the basic medium, and it readily gets excreted from the body.Also Know In basic drug poisoning like amphetamine, we acidify the urine with NH4C1 to change the medium, which opposes reabsorption and hence excretion. N-acetyl cysteine is the DOC for paracetamol poisoning 