<prompt> True regarding multiple myeloma is all. except :Bone painLytic lesionIncreased alkaline phosphataseTaerate resistance acid phosphatase positive  <response>: Answer is C Increased alkaline phosphatase Serum Alkaline phosphatase is usually normal even with extensive bone involvement because of absence of osteoblastic activity - Harrisons 16th 659 Bone pain is the most common symptom in myeloma Q Bone lesions are lytic in nature and are rarely associated with osteoblastic new bone formation. Therefore Radioisotope bone scanning is less useful in diagnosis than plain radiography c No hot spot is seen on bone scan Q Alkaline phosphatase marker of osteoblastic activity is not raised. 