<prompt> Distal Renal tubular acidosis is associated with the following EXCEPTNon-anion gap acidosisUrine pH 5.5HypercalciuriaHypokalemia  <response>: Ans. b Urine pH 5.5 Ref: Harrisons 17th edTable 278.2DISTAL RENAL TUBULAR ACIDOSIS hyperchloremic acidosis. minimum urine pH 5.5 in the presence of systemic acidosis. If doubt, an ammonium chloride loading test is performed Patients with distal RTA will not make urine pH 5.5. Hypercalciuria, an alkaline urine, and a low urine citrate level increase urine saturation with respect to CaP04. Calcium phosphate stones form, nephrocalcinosis is common, and osteomalacia or rickets may occur. RX: with supplemental alkali reduces hypercalciuria and limits the production of new stones. Incomplete RTA may develop in some patients who form calcium oxalate stones because of idiopathic hypercalciuria; the importance of RTA in producing stones in this situation is uncertain, and thiazide Rx is a reasonable alternative.INHERITED TUBULAR DISORDERSDiseaseMode of InheritanceRenal abnormalitiesExtra-renal abnormalitiesType 1 Bartters syndromeARSalt wasting; hypokalemia Type 2 Bartters syndromeARSalt wasting; hypokalemia Type 3 Bartters syndromeARSalt wasting; hypokalemia Type 4 Bartters syndromeARSalt wasting; hypokalemiaSensorineural deafnessType 5 Bartters syndromeADSalt wasting; hypokalemia Gitelmans syndromeARSalt wasting; hypokalemia; hypomagnesemia Pseudohypoaldosteronism Type ARHyperkalemia; salt wastingIncreased lung secretions and inf ADHyperkalemia; salt wasting Primary hypomagnesemiaARHypomagnesemia; nephrocalcinosisHypomagnesemia withARHypomagnesemia; hypocalcemiasecondary hypocalcemia Renal magnesium wastingADHypomagnesemia; hypocalciuriaAutosomal dominantADHypocalcemia; hypercalciuria; hypoparathyroidism hypomagnesemia Liddles syndromeADHypertension; hypokalemia; alkalosisPseudohypoaldosteronismADHypertension; hyperkalemia Type II Gordon syndrome Nephrogenic Dl Type 1XLRenal concentrating defect Nephrogenic Dl Type 2AR, ADRenal concentrating defect Nephrogenic syndrome of inappropriate antidiuresisXLHyponatremia Distal renal tubular acidosisARHyperchloremic metabolicSensorineural deafness acidosis; nephrocalcinosisB1 defect only; growth retardation ARProximal and distal RTA ADDistal RTA Proximal renal tubular acidosisARModerate hyperchloremic metabolic acidosisGlaucoma; band keratopathyCystinuriaARCystine stones; dibasic amino aciduria Hartnup diseaseARNeutral amino aciduria dementiaRash, dermatitis, ataxia;Dents diseaseXLProximal tubular dysfunction; nephrocalcinosisOsteomalacia; ricketsRenal glycosuriaARGlucosuria Hereditary hypophosphatemicARHypophosphatemia;Ricketsrickets with hypercalciuriahypercalciuria Vitamin D-dependent rickets type 1ARHypocalcemiaRickets 