<prompt> Which gene is involved in pathogenesis of Type 1 Diabetes mellitus?CTLA-4ABCD1HNF-1 AlphaHNF-4 Alpha  <response>: Polymorphism in promoter region of insulin gene, CTLA-4 contributes to susceptibility to type 1 Diabetes mellitus. The most common cause of type 1 diabetes mellitus is autoimmunity. Most patients have DR3 and or DR4 haplotype. 