<prompt> Blood transfusion is indicated in the following condition with sickle cell anaemiaFrequent sickling episodesTwin pregnancyPoor obstetrical outcomeAll of the above  <response>: Indications of Blood transfusion in Sickle Cell AnemiaFrequent sickling episodesTwin pregnancyPoor obstetrical outcomeSevere anaemiaBlood transfusion replaces the abnormal cells with normal red cellsThe objective of transfusion is to keep the hematocrit value above 25 and concentration of HbSunder 50 Prophylactic transfusions during pregnancy remain controversial 