<prompt> Which of the vitamin deficiency lead to lacticacidosis?RiboflavinThiaminNiacinPanthotheic acid  <response>: Thiamin The role of thiamin diphosphate in pyruvate dehydrogenase means that in deficiency there is impaired conversion of pyruvate to acetyl CoA. In subjects on a relatively high carbohydrate diet, this results in increased plasma concentrations of lactate and pyruvate, which may cause life-threatening lactic acidosis.- Harper Biologically active form of Thiamin vitamin B1 is Thiamin pyrophosphate or Thiamin diphosphate. Thiamin diphosphate is the coenzyme for 3 multi-enzyme complexes that catalyze oxidative decarboxylation reactions: a. Pyruvate dehydrogenase complex which conves pyruvic acid to acetyl CoA b. Alpha-ketoglutarate dehydrogenase complex in the citric acid cycle which conves alpha-ketoglutarate to succinyl CoA c. Branched-chain keto-acid dehydrogenase involved in the metabolism of leucine, isoleucine, and valine. Thiamin diphosphate is also the coenzyme for transketolase in the HMP pathway of glucose metabolism. 