<prompt> Profound mitotic delay occurs when the doses are:SmallerLargerIntermediateNo effect of doses  <response>: Radiation is especially damaging to rapidly dividing cell systems, such as skin and intestinal mucosa and hematopoietic tissues. Irradiation of such cell populations causes a reduction in size of the irradiated tissue as a result of mitotic delay inhibition of progression of the cells through the cell cycle and reproductive cell death usually during mitosis.The three mechanisms of reproductive death are:DNA damage Bystander effectApoptosisNote: Large dose of irradiation causes mitotic delay. 