<prompt> Hypophosphatesia contraindicated treatment is:Vitamin DCalcium chelating agentEnzyme replacementRenal dialysis  <response>: Ans: a Vitamin DRef: Harrison, 18th ed. Pg. 3141In hypophosphatasia hypercalcaemia and hypercalciuria are common. So in contrast to rickets osteo- malacia, calcium and vitamin D supplementation should be avoided.Hypophosphatasia Caused by deficiency of TNSALP tissue nonspecific alkaline phosphatase Mutation in HOPS gene infantile hypophosphatasia gene on chr lp36. CF-- Polyhydramnios IUD- Infantile - Failure to thrive, rachitic deformities, functional craniosynostosis, raised ICT, pneumonia.- Childhood- Premature loss of deciduous teeth hall mark of disease- Rickets and osteomalacia- Adult - Metatarsal Stress fractures and femoral pseudofractures Inv- Low ALP, hypercalcaemia, hypercalciuria. , normal high phosphorus- PTH, 25D, 1,25 D3 - Normal- High phosphoethanolamine and pyridoxal 5-phosphate specific Rx- Calcium vit D supplementation should be avoided- Low calcium diet- Glucocorticoids- Calcitonin 