<prompt> Type 1 diabetes mellitus is associated with-Male genderOld ageGestational diabetesHLADR3  <response>: Type 1 DM is the result of interactions of genetic, environmental, and immunologic factors that ultimately lead to T-cell mediated autoimmune destruction of the pancreatic beta cells and insulin deficiency. Type 1 DM, which can develop at any age, develops most commonly before 20 years of age. Most individuals with type 1 DM have the HLA DR3 andor DR4 haplotype. There is little or no sex bias within either Type I insulin-dependentalthough most autoimmune diseases dispropoionately affect females or Type II non-insulin-dependent diabetes mellitus. Reference : page 2403 Harrisons Principles of Internal Medicine 19th edition 