<prompt> The apparent volume of distribution Vd of a drug exceeds total body fluid volume, if a drug is:Sequestrated in body tissuesSlowly eliminated from bodyPoorly soluble in plasmaHighly bound to plasma proteins  <response>: - The apparent volume of Distribution Vd Dose administered by IV routePlasma concentration.- Consider the body as a single compartment in which the drug gets homogenously distributed. So it can be defined as, The volume that would accommodate all the drug in the body if the concentration throughout was the same as in plasma.- In the case of lipid insoluble drugs, drugs do not enter the cells. So their V will be similar to ECF volume. - Drugs sequestrated in other tissues may have V much more than total body water or even body mass. 