<prompt> A young man presented with hyper parathyroidism. Which of the following radionuclide scan is done for parathyroid adenoma?Sesta MIBI scanIodine-123 scan99mTc-sulphur colloidGallium scan  <response>: The localization ability of Technetium 99m sestamibi scintigraphy is based on its preferential uptake by parathyroid cells, due to their high mitochondrial activity. Delayed images taken 2 to 3 h after injection are sensitive in up to 90 of single adenoma cases, with over 90 specificity. Sestamibi imaging is also effective in cases of double adenoma. However, it has significantly reduced accuracy in cases of four-gland hyperplasia. Ref: Singer M.C., Terris D.J. 2012. Chapter 43. Parathyroid Disorders. In A.K. Lalwani Ed, CURRENT Diagnosis Treatment in Otolaryngology--Head Neck Surgery, 3e. 