<prompt> A 24 year old male was brought to emergency depament with complaints of nausea and vomiting, sweating, secretions from the eyes,anxiety,yawning, . What shall be the probable diagnosis ?Organophosphate toxicityCannabis toxicityOpioid withdrawalLead toxicity  <response>: OPIOID WITHDRAWAL After withdrawal of the drug for 12 hours and lasts about a week. Clinical feature Yawning is the most common feature. Grading MINOR: Dilated pupils, piloerection, yawning, rhinorrhoea, myalgia, cramps, lacrimation, anorexia. MODERATE: Restlessness, insomnia, hypeension, tachycardia, tachypnoea, diaphoresis. MAJOR: Vomiting, diarrhoea, hyperactive bowel sounds, hypotension. Death is caused by cardiac arrest following an arrhythmia and ventricular fibrillation. Rx- Methadone 25 to 50 mg twice daily helps recovery. 