<prompt> Tensile strength of wound after laparoscopic cholecystectomy in a 30 years old woman depends upon:Replacement of type 3 collagenExtensive crosslinking of tropocollagenMacrophage activityinvasionGranulation tissue  <response>: The recovery of tensile strength results from the excess of collagen synthesis over collagen degradation during the first 2 months of healing, and, at later times, from structural modifications of collagen fibers cross-linking, increased fiber size after collagen synthesis ceases. 