<prompt> Causative factor acne are following except:AndrogenOily foodBacterial proliferationHypercornification of duct  <response>: Acne is a chronic inflammatory disease of the pilosebaceous units, skin structures consisting of a hair follicle and its associated sebaceous gland Major factors are involved in the pathogenesis: - Hormonal factors androgens, Insulin resistance, Insulin growth factor-1IGF-1 - IL-1a activity - Lenoleic acid - Increased sebum production ka Seborrhea, - Hypercornification of the pilosebaceous duct, - Abnormality of the microbial flora especially colonization of the duct with Cutibacterium acnes. - The activity of bacteria C.acnes within the comedones releases free fatty acids from sebum, causes inflammation within the cyst, and results in rupture of the cyst. 