<prompt> Which of the following is the drug of choice for treatment of peptic ulcer disease ?OmeprazolePirenzepineRanitidineSucralfate  <response>: Ans. is a i.e., Omeprazole o PPI are the DOC for peptic ulcer gastric or duodenal, GERD, ZE syndrome, prevention of aspiratory pneumonia and NSAID induced gastric duodenal ulcers. Note - PGE1 analogue Misoprostol is specific drug for prevention and treatment of NSAID induced ulcer, but DOC is PPI. 