<prompt> Female presents with history of color change from pallor to cyanosis on exposure to cold in fingers. This condition is mostly associated with?SclerodermaLeukemiaLung infectionsHepatosplenomegaly  <response>: A. i.e. Scleroderma Raynauds phenomenon i.e. coldvibrationemotional stress-exposure Vt pallor -- cynosis finally erythemaQ of digits, ear tip of nose is almost always present along with skin sclerosis and is often earliest featureQ of Systemic sclerosis Scleroderm. It may precede extensive skin internal organ involvement by week-months in diffuse SS to years in limited cutaneous SS. 