<prompt> In the fed state, major fate of glucose-6-phosphate in tissues is:Storage as fructoseStorage as glyceraldehyde-3-phosphateEnters HMP shunt via ribulose-5-phosphateStorage as glycogen  <response>: Ans. D. Stored as GlycogenRef: Harper 31e page 136,137The uptake of glucose into the liver GLUT 2 is independent of insulin.In the well fed state, the concentration of glucose entering the liver increases, so does the rate of synthesis of glucose-6-phosphateThis is in excess of the livers requirement for energy-yielding metabolism. So it is used mainly for synthesis of glycogen.In both liver and skeletal muscle, insulin acts to stimulate glycogen synthetase and inhibit glycogen phosphorylase. 