<prompt> Sphingolipids are chiefly accumulated in:CNSAdipose tissueCardiac muscleSkeletal muscles  <response>: CNS: Ref: 11-RS, 110-NMS 307-8 U.S 3rdSPHINGOLIPIDS: - They comprise another group of lipids found in biological membrane specially in the tissues of nervous system. There are three types of sphingolipids - sphingomyelin, cerebrosides, gangliosides about 6 of membrane lipids of grey matter cells in the brain and gangliosidesSPHINGOLIPIDOSISDiseaseLipid accumulatedPrimary organ affected1. Niemann-Pick diseaseSphingoymelinBrain, Liver, Spleen2. Gauchers diseaseGlucocerebrosideBrain, Liver, Spleen3. Krabbes diseaseGalactocerebrosideBrain4. Metachromic leukodystrophyb-Sulfagalactoserebrosidase ceramide trihexosideBrainKidney5. Fabrys disease6. Tay-Sachs diseaseGanglioside GM2Brain 