<prompt> Screening test for sclerodemaAnti-nuclear antibodyUl-Ribonucleoprotein antibodyAnti- L.K.M. antibodyAnti- topoisomerase antibody  <response>: Answer- A. Anti-nuclear antibodyANA is the screening method of choice for systemic rheumatic disease such as systemic lupus erythyematous SLE, mixed connective tissue disease, Sjogren syndrome, scleroderma, CREST syndrome, rheumatoid ahritis, polymyositis, dermatomyositis. 