<prompt> Apparent volume of distribution Vd of a drug exceeds total body fluid volume, if a drug is:Sequestrated in body tissuesSlowly eliminated from bodyPoorly soluble in plasmaHighly bound to plasma proteins  <response>: Ans. A Sequestered in body tissuesRef: KDT 8the p24 Apparent volume of distribution Vd is more for drugs sequestered in tissues. Lipid insoluble drugs do not enter cells, Vd approximates ECF volume. 