<prompt> Which of the following vascular lesions has the LEAST clinical significantMonckebergs medial calcificationHyaline aeriolosclerosisHyperplastic aeriolosclerosisGlomus tumor  <response>: Monckeberg;s medial calcification has the least clinical significance. It represents dystrophic calcification often visible on x-ray in the media of muscular aeries. Luminal occlusion does not occur.Aeriolosclerosis is a subclass of aeriosclerosis that primarily involves the aerioles. Hyperplastic aeriolosclerosis involves smooth muscle hyperplasia in the muscle wall with an onion skin appearance; This change is paicularly prominent in the kidneys of patients with malignant hypeension or progressive systemic sclerosis. Hyaline aeriolosclerosis is a small vessel disease associated with diabetes mellitus and essential hypeension.A po wine nevus flammeus in the trigeminal distribution is often associated with Sturge-Weber syndrome. Glomus tumors glomangiomas are painful, benign tumors of modified smooth muscle that are usually located directly beneath the nail bed. 