<prompt> which of the following is not true regarding tri cyclic antidepressentit is safe in bipolar depression as it does not cause switch to maniait causes sedationit causes weigh tgainit causes giddiness  <response>: TCA MECHANISM This is an antidepressant with three rings. It acts by blocking the transpoers of neurotransmitters resulting in increased neurotransmitters in synapse DRUGS AMITRYPTILLINE IMIPRAMINE CLOMIPRAMINE DESIPRAMINE NORIPTILLINE DOXEPINE USE AMITRYPTILLINEPAIN WITH DEPRESSION IMIPRAMINECHILDHOOD ENEURESIS CLOMIPRAMINEOCD SIDE EFFECTS ANTI HISTAMINERGIC sedation, weight gain ANTI MUSCURANICdryness of mouth ANTI ADRENERGIChypotension, giddiness SWITCH TO MANIA when used in BIPOLAR DEPRESSION Ref. kaplon and sadock, synopsis of psychiatry, 11 th edition, 955 