<prompt> All of the following are true of ss thalassemia major, exceptSplenomegalyTarget cells on peripheral smearMicrocytic hypochromic anemiaIncreased osmotic fragility  <response>: In thalassemia major there will be marked splenomegaly,hypochromic microcytic anemia and target cells in peripheral smear. osmotic fragility decreases. Reference: GHAI Essential pediatrics, 8th edition 