<prompt> A 55years male presented with dry mouth, rheumatoid arthritis with high titre of anti SS-A and SS-B antibodies, diagnosed a case of minor salivary gland tumour. The earliest histologic finding inEndothelial cellsBasophilsLymphocyteEosinophils  <response>: Lymphocytes 235-36-Robbins 7th 148- Basic pathology 8th Clinical features and investigation suggest diagnosis is Sjogrens Syndrome SJOGRENS SYNDROME - Triad Dry eye Keroconjunctivitis Dry mouth XerostomiaSicca Rheumatoid arthritis Two antibodies directed against two ribonucleoprotein antigen SS-A Ro and SS-B La. These antibodies are thus considered serologic markers of the disease Sjogren syndrome is in all likehood initiated by CD4 Tcells Associated with EBV, Hepatitis -C, HTLV-1 The earliest histologic finding in both the major and minor salivary glands is periductal andperivascualar lymphocytic infiltration may form pseudolymphoma Biopsy of the lip to examine minor salivary glands is essential for the diagnosis of Sjogrens syndrome 