<prompt> A 27-year-old man with HIV comes to the clinic with symptoms of pain every time he swallows odynophagia He is not on any antiretroviral therapy and otherwise feels well. Examination of the mouth and pharynx are normal. Which of the following is the most likely diagnosis?midesophageal cancerdistal esophageal cancerpeptic strictureCandida infection  <response>: Painful swallowing can be caused by Candida or herpes infection of the esophagus, or pill-induced esophagitis. Patients with immunodeficiency states eg, AIDS may have herpetic, candidal, or CMV esophagitis, as well as tumors lymphoma, Kaposi sarcoma. Candida infection is more common than the other etiologies listed, and therefore the most likely diagnosis. 