<prompt> The Drug of Choice for Sydenham chorea isHaloperidolSodium valproateDiazepamPrednisolone  <response>: D Sodium Valproate?SYDENHAMS CHOREA:oSydenhams chorea SCChorea minorRheumatic chorea RCSt Vitus s Dance:-Major diagnostic criteria for rheumatic disease-Most common acquired chorea during childhood-Characterized by rapid, uncoordinated jerking movements primarily affecting the face, hands and feet.?Treatment of Chorea:oMay be difficult to treat.oTaper or discontinue any medications that can cause or worsen chorea.oIn adults, the mainstay of treatment in adults is Neuroleptics, including Haloperidol Pimozide.oIn children the incidence of side effects in children is high.oTherefore, treatment is usually:-Benzodiazepine, particularly Clonazepam, Diazepam or Clobazam.-Valproate Is the drug of choiceoSydenham chorea generally responds to dopamine-blocking agents - Valproic acid carbamazepine.oBenzodiazepines facilitate the action of GABA and valproate enhances the action on GABA, hence these agents are used to treat choreaoBut it is self limited, and treatment generally restricted to those with severe chorea.oSydenham chorea with recurrence in lateral life as pregnancy Chorea gravidarum or treatment with sex hormones.?Treatment Hyperkinetic Movement Disorders:oDystonia:-Anticholinergic, baclofen, botulinum toxin, globus pallidus internus DBS.oHemifacial spasm:-Botulinum toxinoEssential tremor:-Propranolol, primidone, topiramate, botulinum toxin, ventral intermediate nucleus DBS.oTics Tourettes syndrome:-Fluphenazine, risperidone, botulinum toxin.oChorea huntingtons Disease:-TetrabenazineoMyoclonus:-Clonazepam, levetiracetam, piracetam, sodium valproate.oTardive dyskinesia:-Withdrawal of the causative treatment, tetrabenazine for tardive stereotypy, chorea, tremor, botulinum toxin for tardive dystonia.GENETIC NON-GENETIC CAUSES OF CHOREAGenetic causesNon-genetic causes Huntingtons Disease Sydenhams chorea Neuroacanthocytosis Metabolic causes Benign hereditary chorea Chorea gravidarum Wilsons disease Drug induced chorea Dentatorubropallidolusian atrophy Senile chorea Spinocerebellar ataxia type 2 Vascular chorea McLeod Syndrome Infective causes?CAUSES OF CHOREA:oDrugs:-Levodopa in Parkinsons patients-Oral contraceptive pills-Many psychiatric drugsoVascular disease of the basal ganglia:-Atheroma-Systemic lupus erythematosusoDegeneartive disease:-Huntingtons diseaseoPost-infectious:-Sydenhams choreaoOther causes: Thyrotoxicosis 