<prompt> All of the following are true regarding clofazimine exceptIt is cidal to Mycobacterium lepraeIt has a very long elimination half lifeIt discolours skin and sweatIt has additional antiinflammatory propey  <response>: Clofazimine Clo It is a dye with leprostatic and antiinflammatory propeies. Mechanism of action of clofazimine:- Interference with template function of DNA in M.leprae Alteration of membrane stucture and its transpo function. Disruption of mitochondrial electron trans po chain. Clofazimine is used as a component of multidrug therapy MDT of leprosy. Because of its antiinflammatory propey, it is valuable in lepra reaction. PHARMACOKINETICS Clofazimine is orally active 40-70 absor bed. It accumulates in macrophages and gets deposited in many tissues including subcutaneous fat, as needle-shaped crystals. However, entry in CSF is poor. The t 12 is 70 days so that intermittent therapy is possible Adverse effects:- Skin:- The major disadvantage is reddish-black discolouration of skin, especially on exposed pas. Discolouration of hair and body secretions may also occur. Dryness of skin and itching is often troublesome. Acneform eruptions and phototoxicity have been noted. Conjunctival pigmentation may create cosmetic problem. Ref:- kd tripathi; pg num:-781,782 