<prompt> Use of tiotropium is contraindicated in:Bronchial asthmaHypertensionUrinary retentionPeptic ulcer disease  <response>: SPIRIVA HANDIHALER tiotropium bromide inhalation powder is indicated for the long-term,once-daily, maintenance treatment of bronchospasm associated with chronic obstructive pulmonary disease COPD, including chronic bronchitis and emphysema. SPIRIVA HANDIHALER is indicated to reduce exacerbations in COPD patients 