<prompt> A child with Thalassemia major has a history of treatment for cardiac arrhythmia due to iron overload. Now the child came for regular transfusion and while transfusion the child became anxious and developed complaints of backpain. What is the next management?ECGStop transfusion and look for clerical errorsContinue transfusion while monitoring for vitalsCheck for reddish discolouration of urine  <response>: b. Stop transfusion and look for clerical errors stylefont-size: 1.04761904761905em; font-family: Times New Roman, Times, serifRef: Transfusion reactions:Category 1: Mild reactionsSignsSymptomsPossible causeImmediate managementUrticariarashPruritis itchingAllergic Stop transfusion Assess patient An antihistamine may be required Transfusion may be restarted if no other signssymptoms are present If signssymptoms worsen treat as Category 2. Category 2: Moderately severe reactionsSignsSymptomsPossible causeImmediate managementFlushingUrticariaRigorsFeverRestlessnessTachycardiaAnxietyPruritisPalpitationsMild dyspneaHeadacheAllergic moderately-severeFebrile non-hemolytic transfusion reaction:-antibodies to white cells or platelets Antibodies to proteins including IgA Possible contamination with pyrogens and or bacteria Stop transfusion and maintain IV line with NSaline Contact Medical Officer Patient may require antihistamine andor paracetamol Further investigation and management according to clinical features If investigation required: complete Transfusion Reaction Form and send blood pack, form and samples to blood bank Category 3: Life-threatening reactionsSignsSymptoms Possible cause Immediate managementRigorsFeverRestlessnessHypotensionTachycardiaDark UrineUnexplained bleeding DICAnxietyChest painPain at infusion siteRespiratory distressLoinback painHeadacheDyspneaAcute intravascular hemolysis wrong bloodBacterial contamination and septic shockFluid overloadAnaphylaxisTransfusion related acute lung injury TRALI Stop transfusion and maintain IV line with N.Saline Contact Medical Officer Manage immediate needs:- Fluid for hypotension- Oxygen- Adrenaline for anaphylaxis- Diuretic for fluid overload Complete Transfusion Reaction Form and send blood pack, form and samples to blood bank Further management according to likely cause 