<prompt> Long-term tamoxifen therapy may cause:Endometrium CaOvary CaCervix CaVagina Ca  <response>: Long-term tamoxifen therapy is a predisposing factor for endometrial hyperplasia and cancers.Malignancies caused by Long-term tamoxifen therapy:Carcinoma endometrium-it is the most common carcinoma associated with it.Uterine sarcoma.Rarely liver cancer with a long-term high dose.Non-malignant effects of tamoxifen on uterus:Endometrial hyperplasiaEndometriosisFibroid uterusOvarian cystsMenstrual irregularities or amenorrhea. 