<prompt> Which of the following is fastest calcium lowering agentsCalcitoninPlicamycinEtidronateZoledronate  <response>: Refer CMDT 2010801 Bisphoshonates are the treatment of choice for hypercalcemia of malignancy but require 48-72 hours before reaching full therapeutic effect Calcitonin may be helpful to treat hypercalcemia before the onset of action of bisphoshonates 