<prompt> Which of the following is false regarding brittle bone disease?It is caused by defects in type 2 collagenPredominantly autosomal-dominant inheritance is seenBlue sclerae and deafness may be associatedBisphosphonates are useful in the treatment  <response>: Brittle bone disease is another name for osteogenesis imperfecta OI. It is due to defects in type 1 collagen, not type 2 collagen. There are 12 types of OI, with type 1 being the most common. Triad of fragile bones, blue sclera and deafness is known as van der Hoeve syndrome. Treatment includes bisphosphonate therapy and ohopedic rehabilitation. Ref: Nelson textbook of pediatrics 21st edition pgno: 3737 