<prompt> Amyloidosis is most commonly seen in DM -Maturity onset DMType I DMType II DMHypertension  <response>: C Type II DM 252- Robbins 8th 155 - Robbins - Basic pathology 9,h The two best example of localized amyloidosis are Alzheimers disease and Type II DM In type II DM it is the islet amyloid polypeptide AIAPP also known as Amylin. Amyloidosis in fundamentally a disorder of protein misfolding.Classification of AmyloidosisClinicopathologic CategoryAssociated Disease sMajor Fibril ProteinChemically Related Precursor ProteinSystemic Generalized AmyloidosisImmunocyte dyscrasis with amyloidosis primary amyloidosisMultiplex myeloma and other monoclonal plasma cell proliferationsALImmunoglobulin light chains, chiefly l typeReactive systemic amyloidosis secondary amyloidosisChronic inflammatory conditionsAASAAHemodialysis-associated amyloidosisChronic renal failureAb2mb2-MicroglobulinHereditary AmyloidosisFamilial Mediterranean fever AASAAFamilial amyloidotic severe types ATTRTransthyreinSystemic senile amyloidosis ATTRTranshyretin Localized Amyloidosis Senile cerebralAlzheimer diseaseAbAPPEndocrine Medullary carcinoma of thyroid A CalCalcitoninIslets of LangerhansType 2 diabetesAIAPPIslet amyloid peptideIsolated atrial amyloidosis AANFAtrial natriuretic factor On histologic examination, the amyloid deposition is always extracellular and begins between cells. Kidney - amyloid deposits are found principally in the glomeruli. Liver - amyloid deposits first appear in the space of Disse. They do not provoke an inflammation response. Protein involved in inter cellular connection is - connexin. MC employed stain for amyloidosis is - Congored with polarized light Pinch purpura is diagnostic of systemic primary amyloidosis. 