<prompt> A patient presents with dysphagia of 4 weeks duration. Now he is able to swallow liquid food only. Which of the following is the one investigation to be done?Barium studiesUpper GI EndoscopyCT ScanEsophageal manometry  <response>: Carcinoma Esophagus: Barium swallow is the first investigation for an esophageal disease presenting with dysphagia it can show irregular filling defect with or without proximal dilatation, annular lesion appear as constricting bands Barium Swallow A barium swallow is recommended for any patient presenting with dysphagia. The esophagram gives an overview of anatomy and function It is able to differentiate intraluminal from intramural lesions and to discriminate between intrinsic from a mass protruding into the lumen and extrinsic from compression of a structures outside the esophagus compression The classic finding of an apple-core lesion in patients with esophageal cancer is recognised easily Endoscopy and biopsy is the investigation of choice for CA Esophagus For adequate assessment, both barium swallow and endoscopy are required. Ref: Sabiston 20th edition Pgno: 1028 