<prompt> Skin pigmentation Icthyosis like side effects are seen inRifampicinClofazimineDapsoneSteroid  <response>: Ichthyosis - Fish like scaling dt severe dryness in patient - Causing skin to break Two types - Congenital Acquired I.vulgaris - Autosomal Dominant, MC type Deficiency - Filaggrin Involves Extensors Leprosy - Involvement of ANS No sweating - dry skin X linked ichthyosis - X-linked Recessive defect with steroid sulphatase Extensor Flexors involvement Clofazimine - Causes darkening and dryness of skin Lamellar ichthyosis - Autosomal Recessive Defect with Transglutaminase Whole body involvement When infant born is covered with Membrane called collodion membrane then baby ka collodion baby. Most severe type Ichthyosis - Harlequin ichthyosis - Autosomal Recessive- Due to ABCA-12 gene defect 