<prompt> ANCA is NOT associated with which of the following diseases :Wegeners granulomatosisHenoch schonlein purpuraMicroscopic PANChurg Strauss syndrome  <response>: Answer is B H.S. Purpura : H.S. purpura is not associated with any antinuclear cytoplasmic antibody ANCA. It is an example of ANCA negative vasculitis. ANCA Antineutrophilic cytoplasmic Antibodies arc Antibodies directed against ceain proteins in cytoplasmic granules of Neutrophil monocytes. These are two major categories of ANCA based on different targets for the antibodies. ANCA Antineutrophic cytoplasmic antibodies: ANCA is of 2 types C-ANCA Cytoplasmic proteinase 3q is the target antigen Wegeners Granulomatosisq 90-95 P-ANCA perinuclear myeloperoxidaseQ is the major target antigen Microscopic PAN microscopic polyangitis Churg-Strauss syndrome Crescenteric glomerulonephritise Good pasteurs syndrome 