<prompt> Hepatospleenomegalv with Foam cells is characteristically seen in a Lysosomal disorder. This disorder is due to the deficency ofSphingomyelinaseHexosaminidaseBeta-GalactosidaseBeta-Glucosidase  <response>: A Sphingomyelinase Sphingomyelinase Converts Lipoproteins From Apolipoprotein Deficiency, sphingomyelinase: Also called Niemann-Pick disease, this is a disorder of the metabolism of a lipid fat called sphingomyelin that usually causes the progressive development of enlargement of the liver and spleen hepatosplenomegaly, swollen glands lymphadenopathy, anemia and mental and physical deterioration. Typical cells called Niemann-Pick cellsthat have a foamy appearance due to their storage of sphingomyelin are found in the bone marrow, spleen and lymph nodes. Neurological features of Niemann-Pick disease include mental retardation, spasticity, seizures, jerks, eye paralysis ophthalmoplegia and ataxia wobbliness. Physical growth is retarded. Gastrointestinal features include hepatosplenomegaly, jaundice, hepatic liver failure, and ascites fluid in the abdomen. Eye hallmarks of Niemann-Pick disease include the cherry red spot in the macula in the center of the retina, opacity of the cornea and brown discoloration of the lens capsule. Respiratory problems include pulmonary infiltration. Coronary artery disease occurs early. There is easy bruising. 