<prompt> A 40 year old patient having history of taking Marijuana constantly since 20 years; now he comes to you with withdrawal symptoms. Which is the most frequently encountered symptom?YawningSeizuresIrritabilityNone  <response>: D NoneSubstanceIntoxicationWithdrawalTreatmentAmphetaminesrelease DAEuphoria, Anxiety, Hyper vigilance, Grandiosity, paranoia,Stereotyped behavior, tachycardia, pupillary dilationDepression, fatigue, unpleasant dreams, increased appetiteAnti psychotics or BenzodiazepinesBromocriptines amantadine, DesipramineCocaine prevent re-uptake of DA CaffeineRestlessness, agitation, insomnia, diuresis, GI disturbances, excitementHeadache, fatigue, drowsiness, nausea or vomiting 1-4 daysAvoid caffeine, analgesicsCannabis e.g., Marijuana, hashishImpaired motor coordination, anxiety, slowed reaction time, impaired judgment, conjunctival injection, dry mouth, increased appetiteNoneAbstinence and supportHallucinogens e.g., LSD, mescaline, KetamineHallucinations, illusions, anxiety, ideas of reference, de- personalization, pupillary dilation, tremors, uncoordinationNoneSupportive counseling, talking down, antipsychotics or benzodiazepinesInhalants glue, paint thinnerBelligerence, impaired judgment, nystagmus, uncoordination, lethargy, unsteady gait, crusting around nosemouthNoneEducation and counselingNicotineNone in usual doses but more depression 2X, impotency, traffic accidents, and more days lost from workIrritability, depressed mood and heart rate, increased appetite, insomnia, anxietyNicotine patch, education, bupropion, varenicline, bromocriptine; I trial success to quit 9-10 7-8 K for successOpiates Heroin, Codeine, OxycodonePupillary constriction, constipation, drowsiness, slurred speech, respiratory depression, bradycardia, comaFlu-like muscle aches, nausea or vomiting, yawning, piloerection, lacrimation, rhinorrhea, fever, insomnia, pupillary dilation 7-10 daysNaloxone short halflife; naltrexone longer half-life; clonidine ease withdrawal; methadone, LAMM Levo-ac-aretylmethadol: substitut e addictions, longer withdrawal period; buprenorphine detoxPhencyclidine PCP, angel dustAssaultive, combative, impulsive, agitated, nystagmus, ataxia, hypersalivation, muscle rigidity, decreased response to pain, hyperacusis, paranoia, unpredictable violence, psychosisNoneNon stimulating environment, restraints, vitamin C, benzodiazepine other antipsychoticsSedative hypnotics barbiturates, benzodiazepinesImpaired judgment, slurred speech, uncoordination, unsteady gait, stupor, coma, deathAutonomic hyperactivity tremors, hyperactivity; hallucinations, anxiety, grand mal seizures, deathBarbiturates: pentobarbital challenge test Benzodiazepines: slowly taper dose 