<prompt> Earliest change in atherosclerosis isFatty streaksFibrofatty plaqueCalcificationGelatinous lesions  <response>: A. i.e. Fatty streaks 385- 86 - Harsh Mohan 5th 349 - Basic pathology 8thATHEROSCLEROSIS - is an intima- based lesion organized into a fibrous cap and an atheromatous gruel- like core and composed by smooth muscle cells, endothelial cells inflammatory cells, lipids and necrotic debris Atherosclerosis is a slowly evolving lesion usually requiring many decades to become significant. However acute plaque changes eg rupture, thrombosis or hematoma formation can rapidly precipitate clinical sequalae so-called - Clinical Horizon Early lesions in the form of diffusal internal thickening, fatty streaks and gelatinous lesions Earliest light microscopic changesin MI is- Waviness of the fibresMorphological features, pathogenic events and clinical complications Most common cause of aortic aneurysm is - Athero sclerosis Most common site for MI is - Anterior wall of left ventricles Granulation tissue appears in acute MI - At 1 weeks Calcification of the aortic valve is seen in - Aortic stenosis Me - Collums patch is diagnostic of - Rheumatic endocarditis Osiers node, Janueway and Roth spot seen in Subacute Bacterial endocarditis Most common change in atherosclerotic vessel is - Dystrophic calcification Atherosclerosis LDL is present in LDL monocytes 