<prompt> Mode of inheritance of Leber hereditary optic neuropathy is?Mitochondrial DNA damage disorderLipid storage disorderNucleotide Excision Repair disorderLysosomal storage disorder  <response>: Ans. is a i.e., Mitochondrial DNA damage disorder Important mitochondrial disorders are Pearson syndrome, Leigh syndrome, MELAS, Keamssayre syndrome KSS, Leber hereditary optic neuropathy LHON, Chronic progressive ophthalmoplegia CPEO, Neurogenic weakness with ataxia and retinitis pigmentosa NARP, infantile myopathy and lactic acidosis IMLA, and myoclonic epilepsy with raggedred fibres MERRF. The organ mostly affected are CNS neurological, myocardium, skeletal muscle, kidney and liver, i.e. organs which have large number of mitochondria. 