<prompt> Wilsons disease is characterised by all except?The defective gene is ATP 7ANeurological features include Parkinsonian features and AtaxiaKayser-Fleischer rings and sunflower cataracts are typical eye findingsLiver biopsy is confirmatory for the diagnosis  <response>: Option 1 - ATP7A gene defect leads to Menkes disease. Option 2 - Wilson disease leads to copper accumulation leading to reduced concentration of Ceruloplasmin. Copper is deposited mainly in the liver and brain. Parkinsonism, ataxia, dystonia, subcortical dementia, seizures, psychosis and migraine are all neurological features. Option 3 - Kayser-Fleischer rings copper in Descemets membrane in eye and sunflower cataracts are typical eye findings. Option 4 - Eventhough reduced ceruloplasmin and raised urinary copper may suggest the possibility of Wilsons, the diagnosis is confirmed using a liver biopsy to estimate copper levels. 