<prompt> All of the following factors tend to increase the volume of distribution of a drug EXCEPT:High plasma protein bindingLow ionization at physiological pH valuesHigh lipid solubilityHigh tissue binding  <response>: - Factors affecting drug distribution Lipid solubility - Higher the solubility, higher the distribution Ionization at physiological pH - Higher the ionization, lower the distribution Degree of plasma protein binding - More the binding, less the distribution Affinity for different tissues - Higher affinity, higher distribution Regional blood flow - More the flow, more the distribution Fat: lean body mass ratio changes with age - Increases with age Disease like CHF, uremia, cirrhosis 