<prompt> Botulinum toxin acts on:Inhibition of release of neurotransmitterPost synaptic blockAt synapseReuptake inhibitor  <response>: Ref: KD Tripathi, 7th ed. pg. 99Release of Ach from nerve terminals occurs in small quanta--amount contained in individual vesicles is extruded by exocytosis.Two toxins interfere with cholinergic transmission by affecting release: Botulinum toxin inhibits release Black widow spider toxin induces massive release and depletionBotulinum toxin Botulinum toxin A and B are highly potent exotoxins produced by Clostridium botulinum that are responsible for botulism a type of food poisoning. These neurotoxic proteins cause long-lasting loss of cholinergic transmission by interacting with axonal proteins involved in exocytotic release of Ach. 