<prompt> Most common site of metastasis in Ca colon isLiverLungBoneBrain  <response>: One-third of patients will have liver metastases at the time of diagnosis and 50 will develop them at some point, accounting for the majority of deaths. The lung is the next most common site; metastasis to ovary, brain, kidney, and bone is less common.Ref: Bailey and love, page: 1262 