<prompt> A 17-year-old girl was evaluated for complaints of weight gain, hair loss, constipation and weakness. Her free T4 level was low and TSH was increased. Which of the following is the most likely diagnosis?Graves diseaseMcCune-Albright syndromeTSH-secreting pituitary adenomaHashimotos thyroiditis  <response>: The patient is having symptoms of hypothyroidism and thryoid profile reveals primary hypothyroidism. Analyzing all options, Graves disease and McCune-Albright syndrome are associated with hypehyroidism. excludes a b In pituitary adenomaTSH-secreting pituitary tumor - increased TSH with increased T3T4 would be seen. option c excluded Primary hypothyroidism is dt defect in thyroid gland itself; associated with high TSH low free T4 levels. Hashimotos thyroiditis is a cause of primary hypothroidism. 