<prompt> Type II hypercholesterolemia is due toDefect in scavaging function of HDLDefect in LDL receptorDefect in ABCA proteinDefect in all above  <response>: 2. Type II: Familial Hypercholesterolaemia FHC: A common disorder which has been extensively investigated.The disease is characterised by:Hyper b-lipoproteinemia LDL Associated with increased total cholesterol VLDL may be raised, hence total TG may be high. But plasma usually remains clear.Inheritance: Autosomal dominant; Frequency--0.2 percentEnzyme deficiency metabolic defect: There is no enzyme deficiency. Metabolic defects are:An increased synthesis of apo-B Defective catabolism of LDL. Deficiency of LDL receptors in fibroblasts demonstrated.Clinical features: a Xanthomas of tendinous and tuberous type have been described, b Corneal arcus, c Occasionally xanthelasma. Clinically most impoant is the increased incidence of atherosclerosis and premature cardiovascular diseases.Note: Type-II Pattern can develop as a result of hypothyroidism secondary hyper or lipoproteinemia.Ref: M.N. Chatterjea - Textbook of Biochemistry, 8th edition, page no: 451 