<prompt> All are true regarding Prostaglandins except:LT cause vasoconstriction and decreased vascular permeability20 carbon unsaturated fatsProstacyclin inhibits platelet aggregationProstaglandins cause uterine muscle contraction induce labor  <response>: Ans-ARef: Harpers illustrated Biochemistry,28th editionExplanation:Synthesis from arachidonate See figure on the next pageFUNCTIONSProstacyclin PGI2Inhibit platelet aggregationVasodilatationPGF:Uterine muscle contractionInduce laborBronchoconstrictorPGE:BronchodilatorCauses inflammationThromboxaneSynthesis: plateletFunction: platelet aggregationAspirin - Inhibits TXA2 - Platelet aggregationAspirin is used in the treatment of myocardial infarctionLeukotrienesThe site of synthesis: leukocytes, platelets, macrophagesSlow reacting substance SRS-ALeukotrienes-C, D, EFunctions: InflammationVasoconstrictionBronchoconstriction 