<prompt> The genes involved in CA stomach are all exceptSupression of p53 geneC-kit mutationAPC genek-ras mutation  <response>: Ans. is B C-kit mutationRisk factors for gastric carcinomaA Environmental factors : H. Pylori infection, dietary factors nitritesnitrate, smoked and salted foods, lack of fresh fruitsvegetables, deficiency of vitamin C E, cigarette smoking, and low socioeconomic status.B Host factors : Chronic gastritis causing hypochlorhydria or intestinal metaplasia, partial gastrectomy, gastric adenoma, Barretts esophagus, and Menetrier disease.Intestinal metaplasia is the most significant precursor lesion for Gastric cancer.C Genetic factors : Blood group A, Hereditary nonpolyposis colon cancer syndrome HNPCC and Familial gastric cancer syndrome E-cadherin mutation. Genes and genetic alterations involved in gastric carcinoma arei Intestinal type gastric cancer: K-ras mutation, APC mutation, pS2 methylation, HMLH1 methylation, p16lNK4a methylation, p 73 deletion and C-erb B-2 amplification.ii Diffuse type gastric caner: CDH1 gene E-Cadherin mutation, K-sam amplification.iii For both type: Telomerase reduction telomerase shortening, hTERT expression, genetic instability, overexpressionof the cyclin E CDC25B E2F1 genes,p53 mutations, reduced expression, CD44 aberrabont transcripts, and amplification of the C-met Cyclin E genes.Decreased risk of stomch cancer is seen witho Vitamine C Eo Aspirino Diet high in green leafy vegetables and citrus fruitso Beta - Carotene 