<prompt> Earliest histological change in MI-Macrophage infiltrationNeutrophilic InfiltrationWaviness of fibersCoagulative necrosis  <response>: The microscopic appearance also undergoes a characteristic sequence of changes Typical features of coagulative necrosis become detectable within 4 to 12 hours of infarction. Wavy fibers also can be present at the edges of an infarct; these reflect the stretching and buckling of noncontractile dead fibers. Sublethal ischemia can also induce intracellular myocyte vacuolization; such myocytes are ble but frequently are poorly contractile. Robbins Basic Pathology,9th edition,pg no.383 