<prompt> A 35 year old athlete has height 184 cm., arm span 194cm., pulse rate 64min., BP 14864 mm Hg. Chest ausultation reveals long diastolic murmur over right 2nd intercostal space on routine examination. The probable diagnosis is :Aortic regurgitationAtrial septal defectEbstein anomalyCoarctation of aorta  <response>: Ans. is a Aortic Regurgitation Tall athelete with long arms and long diastolic murmur of aortic regurgitation over right 2nd intercostal space suggests the diagnosis of Marfans syndromeMarfans syndrome: It is characterised by a triad of Abnormality.Long thin extremities frequently associated with other skeletal changes.Reduced vision as the result of dislocation of lensesAortic Aneurysms that typically begin at the base of the Aorta. if the dilatation occurs at the root of the Aorta it can lead to Aortic regurgitation .Marfans Syndrome : Characterstic findingsSkeletal changes of Marfans syndrome :Patients are usually tallHave long limbsThe ratio of upper segment to lower segment is usually 2 SDs below the mean for age, race sex.Arachnodactyly fingers are long and slender spider like in appearancePectus Excavation, Pectus Carinatum. Scoliosis, Kyphosiscardiovascular changesMitral valve prolapse Mitral valve prolapse progresses to Mitral valve Regurgitation Aortic Aneurysm occurs it can lead to Aortic Regurgitation, Dissection of Aorta Rupture. Ocular changesDislocation of the LensElongation of globe MyopiaRetinal detachment. Associated changesSpontaneous pneumothoraxInguinal incisional herniasStriae may occur over the shoulders buttocks. 