<prompt> Antidote for organophosphorous poisoning is ?AtropineNeostigmineSuccinylcholineD-Tubocurarine  <response>: Ans. is a i.e., Atropine Pharmacological treatment of organonhosphatepoisoning Atropine o Atropine is the mainstay of treatment antidote of choice. o Atropine antagonizes the muscarinic parasympathetic effects of organophosphate excessive secretion and vasodilation, but does not antagonize nicotinic effects, i.e., neuramuscular blockers Atropine blocks muscarinic receptors, i.e., it is an antimuscarinic o Atropine antagonizes both peripheral as well as central nervous system effects of organophosphates. Cholinesterase regenerator compounds oximes o Pralidoxime is most commonly used oxime. o Unlike atropine, they antagonize both muscarinic and nicotinic effects. o They antagonize only peripheral effects, but not central effects except for diacetylmonoxime DAM which crosses BBB and antagonizes central effects also. 