<prompt> Pulseless disease is -Giant cell aeritisTakayasu aeritisKawasaki diseasePolyaeritis nodosa  <response>: Ans. is b i.e., Takayasu aeritisTakayasu aeritis o Takayasu aeritis is gran u lomatous vasculitis of large and medium aeries.o It is characterized principally by ocular disturbance and marked weakening of pulses in the upper extremities -- Pulseless disease.o It is also characterized by a strong predilection for aoic arch and its branches -- Aoic arch syndrome. o It is more common in Adolescent girls and young women.o Morphological changes in vessel wall are same as in giant cell aeritis.Clinical presentationSymptoms are mainly according to the involved vessel -Subclan aery :o Most commonly involved vesselo Symptoms are - Arm claudication, lower BP and weaker pulse in upper limb then in lower limb, Raynauds phemomenon. Common carotid - Visual disturbances, stroke, TIA, syncope. Abdominal aoa or coeliac aery or superior mesentric aery -- Abdominal pain, nausea, vomiting Renal -- Hypeension, Renal failure Aoic root -- Aoic regurgitation, CHF Veebral Visual disturbances Iliac - Leg claudication Pulmonary -- Pulmonary hypeension, dysnea, chest pain. Coronary Angina, MI Constitutional symptoms -- As with other vasculitis malaise, fatigue, anarexia and weight loss are common. Elevated ESR and Anemia as with other vasculitis 