<prompt> Mycosis fungoides mainly affectsB-cellsPlasma cellsT cellsMacrophages  <response>: Ans. c T-cells. Ref. Robbin, Pathology, 6,h656, 670, 1191 Harrisons Medicine 18thTable 12-8.MYCOSIS FUNGOIDES CUTANEOUS T CELL LYMPHOMA SEZARY SYNDROME It is anindolent disorder of peripheral CD4T-cells. It is an indolent lymphoma with several years of eczematous or dermatitic skin lesions before the diagnosis. The median age of onset is in the mid-fifties. It is more common in males and in blacks. Patients are usually adults with cutaneous patches, plaques, nodules or generalized erythema. Characteristically 3 phases are known:- Premycotic - plaque -tumor phase. The skin lesions progress from patch stage to plaque stage to cutaneous tumors. In advanced stages, the lymphoma can metastasize to lymph nodes and visceral organs. Lymphoma involves erythroderma and circulating tumor cells is known as Sezarys syndrome. Localized early stage mycosis fungoides can be cured with RT, often total-skin electron beam irradiation More advanced disease has been treated palliative with:- Topical glucocorticoids, Topical nitrogen mustard,- Psoralen with ultraviolet PUVA, Phototherapy,- Interferon, Antibodies, Fusion toxins, and- Systemic cytotoxic therapy. 