<prompt> Insulin secretion is normally stimulated byGLP-1GLP-2VIPAdrenergic receptor  <response>: Insulin secretion is normally stimulated by GLP-1. Glucagon like peptide-1 GLP-1 and glucose-dependent insulinotropic peptideGIP are called incretins and potent stimulators of insulin secretion. They also inhibit glucagon secretion. They are released in the gastrointestinal tract after a person eats a meal. They then cause an anticipatory increase in blood insulin in preparation for the glucose and aminoacids to be absorbed from the meal. Factors affecting insulin secretion Stimulators Inhibitors Glucose 2-Deoxyglucose Mannose Mannoheptulose Glucagon Somatostatin Aminoacids- leucine arginine Intestinal hormones- GIP, GLP-1, gastrin, secretin, CCK K depletion Acetlycholine parasympathetic stimulation Leptin b-adrenergic stimulators Theophylline Sulfonylureas a-adrenergic stimulators norepinephrine, epinephrin b-adrenergic blockers propanalol Diazoxide Thiazide diuretics Phenytoin Alloxan Microtubule inhibitors Taxanes, Vinca, alkaloids Insulin Ref: Guyton and Hall 13th edition PGno: 991 