<prompt> Initiating event of Endotoxic shockEndothelial injuryPeripheral vasodilata onCytokinin actionDecreased pumping of hea  <response>: The receptor for the endotoxin in humans is the TLR-4 located on the surface of antigen presenting cells. b. Binding to the receptor activates a cascade of enzymatic reactions which finally leads to the activation of the genes for the proinflammatory cytokines. Ref ganongs review of medical physiology 25e p465 