<prompt> All of the following are good prognostic factors for pediatric acute lymphoblastic leukemia, except:CNS disease at diagnosisInitial WBC count of 50000cummHyperdiploidyt12;21  <response>: Favorable prognostic markers include Age between 1 and 10 years, A low white cell count at diagnosis, Hyperdiploidy, Trisomy of chromosomes 4, 7, and 10, and the presence of a t12;21. Several factors are associated with a worse prognosis: Infancy, older age at diagnosis presentation in adolescence or adulthood Translocations involving the MLL gene Higher WBC count at diagnosis peripheral blood blast counts greater than 100,000cumm Presence of CNS disease at diagnosis Hypodiploidy 