<prompt> Gitelmans syndrome resembles the effects of which of the following drugs?ThiazideFurosemideSpironolactoneAmiloride  <response>: Ans. is a i.e., Thiazide Gitelmans s syndrome Gitelmans syndrome is due to mutations in the thiazide-sensitive Na-Cl co-transporter, NCCT, in the distal convoluted tubule DCT. Defects in NCCT in Gitelmans syndrome impair sodium and chloride reabsorption in the DCT and thus resemble the effects of thiazide diuretics. It remains unclear how this defect leads to severe mag- nesium wasting. Gitelmans syndrome is more common than Bartters syndrome and has a generally milder clinical course with a later age of presentation. It is characterized by prominent neuromuscular symptoms and signs, including fatigue, weakness, carpopedal spasm, cramps, and tetany. Gitelmans syndrome is distinguished from most forms of Bartters syndrome by the presence of severe hypomagnesemia and hypocalciuria. 