<prompt> Thiazolidinedione is associated with increasedrisk of?Hea failurePulmonary fibrosisMyocarditisrenal dysfunction  <response>: Ans. is a i.e., Hea failure Thiazolidinediones adverse effects Plasma volume expansion, edema, weight gain, headache, myalgia and mild anemia. Few cases of hepatic dysfunction and some cardiovascular events have been repoed - CHF may be precipitated - they are contraindicated in liver disease and in CHF. Rosiglitazone has been found to increase the risk of fracture, especially in elderly women. Glitazones with insulin can precipitate CHF - avoid such combination. These drugs prevent type 2 DM in prediabetics. 