<prompt> Most common syndrome associated with cleft palatePierre Robin sequenceStickler syndromeTreacher Collins syndromeDowns syndrome  <response>: Although most clefts of the lip and palate occur as an isolated deformity, Pierre Robin sequence is an impoant association. This sequence comprises isolated cleft palate, retrognathia and a posteriorly displaced tongue glossoptosis, which is associated with early respiratory and feeding difficulties. Stickler ophthalmic and musculoskeletal abnormalities, Shprintzen cardiac anomalies, Down, Ape and Treacher Collins syndromes are other common syndromes where cleft lip and palate are frequently encountered.Ref: Bailey and love pg: 689 