<prompt> Proptosis is not seen inGraves diseaseSarcoidosisPituitary adenomaMyxoedema  <response>: Ans. is d i.e., Myxoedema Proptosis occurs in thyrotoxicosis not in hypothyroidism Choices Logic Graves Cytokines appear to play a major role in thyroid-associated ophthalmopathy There is infiltration of the extraocular muscles by activated T cells; the release of cytokines such as IFN-alpha and TNF results in fibroblast activation and increased synthesis of glycosaminoglycans that trap water, thereby leading to characteristic muscle swelling Sarcoidosis Approximately 20, of patients with ophthalmic findings of sarcoid have soft tissue involvement of the orbit or lacrimal gland and present as a mass lesion with proptosis, ptosis, or ophthalmoplegia. Pituitary adenoma Macro-adenoma associated with pituitary apoplexy can lead to proptosis. 