<prompt> Drug of choice in Acute central anticholinergic syndrome is -NeostigminePhysostigmineTacrine4-amino pyridine  <response>: Ans. is b i.e., Physostigmine Physostigmine penetrates blood-brain barrier and antagonizes both central and peripheral actions of anticholinergics in acute anticholinergic poisoning belladonna poisoning. About other options o Neostigmine does not cross blood brain barrier. Thus it is ineffective for central anticholinergic actions. o Tacrine is used for chronic central anti-cholinergic syndrome Alzhiemers disease. 