<prompt> D-dimer is the most sensitive diagnostic test forPulmonary embolismAcute pulmonary oedemaCardiac tamponadeIdiopathic pulmonary fibrosis  <response>: The quantitative plasma D-dimer ELISA rises in the presence of DVT or pulmonary embolism because of the breakdown of fibrin by plasmin.The sensitivity of the D-dimer is 95 for pulmonary embolism.This test is less sensitive for DVT80 than for PE because the DVT thrombus size is smaller.But this assay is not specific.Levels increase in patients with MI,pneumonia,sepsis,cancer,post operative period in the second and third trimesters of pregnancy. Reference:Harrisons medicine-18th edition,page no:2172. 