<prompt> Therapeutic index is a measure ofPotencyEfficacySafetyPotency efficacy  <response>: c Safety,Ref: Lippincott, 6th ed., pg. 35The therapeutic index TI of a drug is the ratio of the dose that produces toxicity to the dose that produces a clinically desired or effective response in a population of individuals:TITD50ED50Where TD50 the drug dose that produces a toxic effect in 50 the population and ED50 the drug dose that produces a therapeutic or desired response in 50 the population. TI is a measure of a drugs safety, because a larger value indicates a wide margin between doses that are effective and doses that are toxic. 