<prompt> In which of the following pathological processes caspases are involved in?ApoptosisFatty changeHydropic degenerationCollagen hyalinosis  <response>: Apoptosis can be initiated by external signals that have features in common with those used by ligands such as TNF- or by an internal pathway activated by DNA damage, improperly folded proteins, or withdrawal of cell survival factors. Regardless of the mode of initiation, the apoptotic program is carried out by a large family of cysteineproteases termed caspases. The caspases are highly specific cytoplasmic proteases that are inactive in normal cells but become activated by apoptotic signals. Ref: Blumenthal D.K., Garrison J.C. 2011. Chapter 3. Pharmacodynamics: Molecular Mechanisms of Drug Action. In L.L. Brunton, B.A. Chabner, B.C. Knollmann Eds, Goodman Gilmans The Pharmacological Basis of Therapeutics, 12e. 