<prompt> Which antihypeensive is a prodrug and is coveed to its active form in brain?ClonidineMethyldopaMinoxidilNitroprusside  <response>: Ref: KDT 6e p547 Although both methyldopa and minoxidil are produrgs, conversion of methyldopa to a-methylnorepinephrine takes place in the brain whereas minoxidil is activated to minoxidil sulphate by phase II reaction in the periphery. 