<prompt> Oligospermia caused by aEURMethotrexateHydroxychloroquineLeflunomideD-peniollamine  <response>: Methotrexate Transient but reversible oligospermia has been repoed in males receiving high dose methotrexate for cancer chemotherapy. Defective oogenesis or spermatogenesis Occurs in methotrexate therapy 