<prompt> Juvenile CML is characterized by all EXCEPT:Increased HbFPhiladelphia chromosomeImmature granulocyteNucleated RBC  <response>: -JMML is a childhood mixed MDSMPD that includes childhood leukemias previously classified as CMML, juvenile CML, and infantile monosomy 7 syndrome. - Remember: presence of bcrabl fusion Philadelphia chromosome is not compatible with a diagnosis of juvenile myelomonocytic leukemia JMML. Diagnostic criteria of JMML: Category -1 - Age 13yrs - Splenomegaly - Absolute monocyte count 1000cu mm - Blasts in peripheral bloodmarrow 20 - Absent philadelphia chromosome BCR ABL fusion gene Category -2 - Somatic mutation in RAS PTPN11 - Clinical diagnosis of NF-1 Monosomy-7 Categoty - 3 - Circulating myeloid precursors - Leukocytes 10,000cu mm - Elevated fetal Hb, HbF - clonal cytogenetic abnormalities 