<prompt> In the well fed state, major fate of glucose-6-phosphate in tissues is:Storage as fructoseStorage as glyceraldehyde-3-phosphateEnters HMP shunt via ribulose-5-phosphateStorage as glycogen  <response>: The uptake of glucose into the liver through GLUT 2 is independent of insulin.In the well fed state, the concentration of glucose entering the liver increases, so does the rate of synthesis of glucose-6-phosphate.This is in excess of the livers requirement forenergy-yielding metabolism. So, it is used mainly for synthesis of glycogen.In both liver and skeletal muscle, insulin acts to stimulate glycogen synthase and inhibit glycogen phosphorylase.Harper 30th edition pg -148 