<prompt> Drug capable of causing ocular hypotension with apnoea in infants isLatanoprostBrimonidineApraclonidineAcetazolamide  <response>: Brimonidine Brimonidine, an alpha 2 selective adrenergic agonist used in treatment of Glaucoma has propensity to cause respiratory depression when used in children. Brimonidine is notorious in causing CNS depression and apnoea in neonates. Hence, its use in children 2 years of age is contraindicated. Brimonidine and Apraclonidine are Clonidine derivates - alpha 2 selective adrenergic agonist - reduce intraocular pressure by decreasing aqueous production. Unlike Apraclonidine, Brimonidine being lipophilic can traverse the blood brain barrier and induce CNS depression. Brimonidine is administered as topical eye preparation to reduce IOP in ocular hypeension and open angle glaucoma. Topical Brimonidine gel 0.33 is also used as a once daily treatment for persistent erythema of rosacea. Ref:- Goodman Gilman Pharmacological Basis of Therapeutics 13th Ed; Pg num:- 1260 