<prompt> First purine nucleotide, which is synthesized in purine biosynthesis ?AMPGMPIMPUMP  <response>: The biosynthesis of purine begins with ribose-5-phosphate, derived from pentose phosphate pathway PPP. First intermediate formed in this pathway, 5-phosphoribosyl-pyrophosphate PRPP, is also an intermediate in purine salvage pathway. REF: Lippincott book of biochemistry 6th ed. 