<prompt> All of the following statements about unfractionated heparin are true except:-It is a powerful anticoagulant only in vivoProtamine sulfate is the antidoteIt should not be given by intramuscular routeIt acts by inhibiting factor IIa and Xa  <response>: Heparin Warfarin 1. Route of administration parenteral IV, SC Oral 2. Onset of action Rapid Delayed 1-3 days 3. Activity In vitro and in vivo In vivo only 4. MOA Activates Antihrombin III Activation of II, VII, IX, X 5 Monitoring by aPTT PT 6. Antagonist Protamine sulphate Vit. K1 Phytonadione 7. Placental barrier Does not cross placenta Fetal warfarin syndrome 8. Use To initiate therapy For maintenance 