<prompt> A newborn is found to have a defect in the central abdomen at bih. All of the following features are suggestive of Omphalocele as a diagnosis except thatThe defect is openAssociated with trisomy 13Associated with other congenital anomaliesUmbilical cord is at the apex of membrane  <response>: Omphalocele- larger defect, covered by a membrane, Higher association with anomalies, bowel usually normal.CONGENITAL OMPHALOCELEAn omphalocele is a herniation or protrusion of the abdominal contents into the base of the umbilical cord. In contrast to the more common umbilical hernia, the sac is covered with peritoneum without overlying skin. Immediate surgical repair, before infection, has taken place and before the tissues have been damaged by drying saline-soaked sterile dressings should be applied immediately or by rupture of the sac, is essential for survival.The majority ?75 of infants with omphalocele have associated congenital anomaliessyndromes, including Beckwith-Wiedemann syndrome omphalocele, macrosomia, hypoglycemia, and other chromosomal 29, including trisomies 13 and 18 and nonchromosomal 45 multiple and isolated congenital anomalies musculoskeletal, 24; urogenital, 20; cardiovascular, 15; and central nervous system, 9. The survival rate is approximately 80 overall, but in infants with isolated omphalocele, the survival rate is 90.Ref: Nelson Textbook of Pediatrics; 20th edition; Page no: 890 