<prompt> Which antimalarial drug is known to cause neuropsychiatric reaction as its adverse effect?ArtesunateArtimisninQuinineMefloquine  <response>: Ans. d. Mefloquine Ref H-17th1288.Acute reversible cognitive dysfunction and neuropsychiatric reaction manifested by confusion, psychosis, convulsions, or encephalopathy is a SE known with Mefloquine. Approximately 1 in every 10,000 recipients develops it.MEFLOQUINE Mefloquine 250 mg of salt weekly, adult dose has been the antimalarial prophylactic agent of choice for much of the tropics because it is usually effective against multidrug-resistant falciparum malaria and is reasonably well tolerated. SE include:- Mild nausea,- dizziness,- fuzzy thinking,- disturbed sleep patterns,- vivid dreams, and- malaise The role of mefloquine prophylaxis dunng pregnancy remains uncertain; in studies in Afnca, mefloquine prophylaxiswas found to be effective and safe during pregnancy.Also Know:Neuropsychiatric side effects are known with: Efavirenz therapy Anticholinergics Aminophylline and salbutamol. Baclofen and dantrolene NSAIDs Corticosteroids Oestrogens, progesterone and its analogues and OC pills Opioid and opioid antagonists Antimigrane sumatriptan and Antiepileptics Calcium- channel blockers Sodium nitroprusside Cycloserine 