<prompt> Lactic acidosis is a side effect ofChlorothiazideMetforminCyclosporinePentamidine  <response>: B Metformin LACTIC ACIDOSIS: occurs when the rate of production of lactic acid from pyruvate in muscle, skin, brain erythrocytes exceeds the rate of removal by liver kidney. Causes of Lactic Acidosis: Group A Due to poor tissue perfusion Shock from any cause, Respiratory failure, Severe anaemia, Mitochondrial enzyme inhibitor Cyanide or CO Group B Due to aerobic disorder Diabetes mellitus; Hepatic failure; Renal failure; Severe infection cholera, malaria Malignancies; Seizures Drugs biguanides such as metformin, salicylates, isoniazid, sorbitol, AZT analogues, fructose Toxins ethanol, methanol, Congenital enzyme defect 