<prompt> A patient presents with Endocrinopathy, fibrous dysplasia of bone and hyperpigmentation. Diagnosis is?McCune Albright syndromeAddisons diseaseAlagille syndromeLynch syndrome  <response>: Ans. a McCune Albright syndromeRef: Robbins 9thpg 1206-1207McCune-Albright syndromeGeneticsIt is due to GNAS mutation - continuous activation of stimulatory G proteinPatho physiologyIncreased production of hormones by glands regulated by the G protein systemClinical featuresPrecocious puberty, Polyostotic fibrous dysplasia, unilateral Cafe au lait spots 