<prompt> Cardiomyopathy is caused byActinomycin DDoxorubicinMitomycin CMitoxantrone  <response>: Ref: Katzung 14th ed. pg. 964-65; KDTy 6th ed. pg. 826-27 Doxorubicin and daunorubicin are anti-tumor antibiotics. Activity of Daunorubicin is limited to acute leukemia while doxorubicin is effective in several solid tumors. MOA: Cause breaks in DNA strands by activating topoisomerse II and generating quinolone type free radicals. Doxrorubicin and daunorubicin both these antibiotics produce cardiotoxicity as a unique adverse effect. Actinomycin D Dactinomycin It is a very potent antineoplastic drug, highly efficacious in Wilms tumour and rhabdomyosarcoma Prominent adverse effects are vomiting, stomatitis, diarrhoea, erythema and desquamation of skin, alopecia and bone marrow depression Mitoxantrone: Recently introduced analogue of doxorubicin with lower cardiotoxicity, probably because it does not produce quinine type free radicals. Though cardiomyopathy can occur, major toxicity is marrow depression and mucosal inflammation. Mitomycin C: This highly toxic drug is used only in resistant cancers of stomach, cervix, colon, rectum, bladder, etc Bone marrow and GIT are the primary targets of toxicity. 