<prompt> All of the following are seen in active chronic hepatitis B except -IgM against core antigenTotal core antibodyHbeAgHbsAg  <response>: Hepatitis B core antigen Hepatitis B core antigen HBcAg is not found in the blood, but antibody to it anti-HBc appears early in the illness and rapidly reaches a high titre, which subsides gradually but then persists. Anti-HBc is initially of IgM type, with IgG antibody appearing later. Anti-HBc IgM can sometimes reveal an acute HBV infection when the HBsAg has disappeared and before anti-HBs has developed . Ref Davidson edition23rd pg874 