<prompt> A 55 years aged chronic alcoholic male, presented with irrelevant talks, tremor and sweating. He had his last drink 3 days back. What will the probable diagnosis?Delirium tremensKorsakoff psychosisPost-Acute withdrawal syndromeDiscontinuation syndrome  <response>: The description of symptoms is related to the condition Delirium Tremens Delirium Tremens Alcohol Withdrawal Delirium AWD: Most severe form of ethanol withdrawal manifested by, Altered mental status Global confusion Autonomic hyperactivity Sympathetic overdrive Mechanism: Alcohol abuse affects neurotransmitter systems in brain mainly by, Loss of GABA inhibitory mechanism - Reduces chloride ion influx. Alcohol acts as NMDA receptor antagonist - Withdrawal increases the excitatory neurotransmitter. The clinical manifestations of ethanol withdrawal are combination effects of GABA NMDA receptor activity. Thus causing tremors, diaphoresis, tachycardia, anxiety in severe cases Seizure. REF: DAVIDSONS 10TH ED 