<prompt> During sleep which hormone is increased?SerotoninDopamineGABAAch  <response>: Ans. D Ach Awake state: Increase activity of norepinephrine- and serotonin-containing neurons locus coeruleus and raphe nuclei and reduced level of activity in acetylcholine- containing neurons pontine reticular formation. Reduced GABA release and increase histamine release is also there. REM state: Decrease activity of norepinephrine- and serotonin-containing neurons and increased level of acetylcholine containing neurons NREM sleep: Increased release of GABA and reduced release of histamineExtra Mile Serotonin: Old concept- necessary to obtain and maintain behavioral sleep permissive role on sleep Serotonin: recent concept-suggests that during waking, serotonin may complement the action of nor-adrenaline and acetylcholine in promoting cortical responsiveness and participate to the inhibition of REM sleep effector neurons of the brainstem inhibitory role on REM sleep Cortical Ach; Greatest during REM sleep waking and reduced during non-REM NREM sleep. 