<prompt> Bone marrow examination of a 2 year old child with massive splenomegaly and pancytopenia showed cells with wrinkled paper appearance of cytoplasm. What could be the possible diagnosis?Niemann Pick diseaseGaucher diseaseAcute LeukemiaHereditary spherocytosis  <response>: Given scenario suggests Gaucher disease Gaucher disease is the most common lysosomal storage disorder with a defect of lysosomal enzyme acid b glucosidase. Gaucher cells are lipid laden macrophages that show a characteristic histologic appearance of wrinkled tissue paper of cytoplasm. 