<prompt> Pyruvate utilisation is decreased in:Pernicious anemiaScurvyFolate trapBeri-beri  <response>: PDH complex requires five coenzymes - Vitamin B1, B2, B3, B5 and Lipoic acid. Vitamin B1 deficiency - Beri-beri Beri- beri - PDH activity - pyruvate to acetyl-CoA conversion - low pyruvate utilization Vitamins B1, B2, B3, B5 - decreased energy production and CNS problems brain cells depend upon this aerobic reaction 