<prompt> Gastric carcinoma is associated with all EXCEPT -Inactivation of p53Over expression of C-erbOver expression of C-metNone  <response>: Ans. is Noneo In the course of multi-step stomach carcinogenesis, various genetic and epigenetic alterations of oncogenes, tumor-suppressor genes, DNA repair genes, cell cycle regulators and cell adhesion molecules are involved. o Genetic alteration in gastric cancer include:i Intestinal type gastric cancer: K-ras mutation, APC mutation, pS2 methylation, HMLH1 methylation,p16m4 methylation, p 73 deletion and C-erb B-2 amplification.ii Diffuse type gastric caner: CDH 1 gene E-Cadherin mutation, K-sam amplification.iii For both type: Telomerase reduction telomerase shoening, hTE expression, genetic instability, overexpressionof the cyclin E CDC25B E2F 1 genes, p53 mutations, reduced expression, CD44 aberrabont transcripts, and amplification of the C-met Cyclin E genes.Coming to question:o All the given four genetic alterations may be associated with stomach cancer.o However among the given options K-ras is best answer as it is associated with gastric cancer in minimum percentage amongst given options:Source: Textbook of mechanism of carcinogenesis and cancer preventionK-ras mutation 10p53 mutation -- 30-60C-erb B-2 amplifcation - 20C-met amplifciation 20 