<prompt> CD-15 helps in assessment of which of the following:March 2010Adult T-cell leukemiaHodgkins diseaseMycosis fungoidesLarger granular lymphocytic leukemia  <response>: Ans. B: Hodgkins diseaseCD15 3-fucosyl-N-acetyl-lactosamine is a cluster of differentiation antigen - an immunologically significant molecule. CD15 is a carbohydrate adhesion molecule not a protein that can be expressed on glycoproteins, glycolipids and pro teoglycansCD15 mediates phagocytosis and chemotaxis, found on neutrophils; expressed in patients with Hodgkin disease, some B-cell chronic lymphocytic leukemias, acute lymphoblastic leukemias, and most acute nonlymphocytic leukemias. It is also called Lewis x and SSEA-1 stage-specific embryonic antigen 1 and represents a marker for murine pluripotent stem cells, in which it plays an impoant role in adhesion and migration of the cells in the preimplantation embryo. It is synthezised by FUT4 fucosyltransferase 4 and FUT9. 