<prompt> The peripheral smear of Hereditiary spherocytosis will show spherocytes -Usually of same size as RBCsReticulocytosis absentAnemia is negligibleSmaller size than RBCs  <response>: Various mutations involving membrane skeletal proteins weakens interactions bw proteins and cause red cells to lose memb fragments . This causes decrease in size of the spherocytes compared to normal RBCs Ref: Robins 9e pg:632 