<prompt> Rapidly progressive glomerulonephritis is characterized histologically byFibromuscular hyperplasia of the renal aeryCrescents in the glomeruliNeutrophils in the interstitiumSplitting of the basement membrane by mesangial cells  <response>: The finding of crescents within the Bowmans space of many glomeruli is diagnostic of rapidly progressive crescentic glomerulonephritis RPGN. RPGN may be subdivided into three types based on the immunofluorescence IF staining pattern. Type I RPGN reveals linear staining of IgG and C3. The majority of these patients are found to have Goodpastures disease anti-GBM disease. Type II RPGN reveals immune complex deposition granular staining. These patients may have other glomerular or systemic diseases, including post-streptococcal GN, membranoproliferative GN, IgA nephropathy Bergers disease, and SLE. Type III RPGN reveals minimal immune changes and is referred to as pauci-immune crescentic GN. Antineutrophil cytoplasmic antibodies ANCAs, which are found in some patients with vasculitis, are found in many of these patients with pauci-immune GN. ANCAs are either perinuclear P-ANCAs, against myeloperoxidase or cytoplasmic C-ANCAs, against proteinase 3. P-ANCAs are found in patients with microscopic polyaeritis and idiopathic crescentic GN, while C-ANCAs are found in patients with Wegeners granulomatosis, a disorder that is characterized by acute necrotizing granulomas of the respiratory tract, focal necrotizing vasculitis, and diffuse necrotizing GN Reference: Robbins Cotran Pathologic Basis of Disease, 9edition 