<prompt> Tangier disease is characterised by:Extremely low circulating level of plasma cholesterolLow level of LDL but high HDL levelExtremely low level of triglyceridesVery high level of triglycerides  <response>: Tangier disease is a very rare autosomal dominant form of extremely low plasma HDL-Cholesterol caused by mutations in the gene encoding ABCA1. Reference: Harrisons Principles of Internal Medicine, 18th Edition, Page 3154 