<prompt> A 50 years old male with type 2 diabetes mellitus is found to have 24-hour urinary albumin of 250 mg. Which of the following drugs may be used to retard progression of the renal disease?HydrochlorothiazideEnalaprilAmilorideAspirin  <response>: Antihypeensive drugs in Diabetes MellitusACE inhibitors enalapril or angiotensin receptor blockers are the first line of therapy in hypeensive individuals with type 2 DM.They have no known adverse action on glucose or lipid metabolism.Minimize the development of diabetic nephropathy by reducing renal vascular resistance and renal perfusion pressure-the primary factor underlying renal deterioration in these patients.Refer: Harrisons Principles of Internal Medicine, 18th edition, pg no: 2054-2058 