<prompt> Clozapine was the first antipsychotic drug. Which of the following is an indication for the use of Clozapine?Resistant schizophreniaAkathesiaFirst drug to be used for schizpophreniaUsed for schizophrenia with depression  <response>: Clozapine has been approved for, Patients with schizophrenia who have failed to respond adequately to typical neuroleptic drugs treatment-resistant schizophrenia Patients who are intolerant of typical neuroleptic drugs because of EPS or tardive dyskinesia Patients who are at high risk for suicide Ref: Meltzer H.Y., Bobo W.V., Heckers S.H., Fatemi H.S. 2008. Chapter 16. Schizophrenia. In M.H. Ebe, P.T. Loosen, B. Nurcombe, J.F. Leckman Eds,CURRENT Diagnosis Treatment: Psychiatry, 2e. 