<prompt> LE cell is seen in ?Lupus erythmatosusLupus vulgarisHNPCCMedullary carcinoma of thyroid  <response>: Ans. is a i.e., Lupus erythematousus In SLE, antinuclear antibodies AN Ps can not penetrate intact cells. However, nuclei are exposed, ANA can bind to them. In tissues, nuclei of damaged cells react with ANAs, lose their chromatin pattern, and become homogeneous, to produce lupus - erythematous LE bodies or hemotoxylin bodies. When these LE bodies are engulfed by phagocytic cells neutrophil or macrophagemonocyte, the phagocytic cells are called LE cells. 