<prompt> Defect in folding of the protein result in which of the following clinical disease:-KuruMigraineHypothyroidismMyopia  <response>: Ans. is a Kuru .Prion diseases are known to occur because of defect in the secondary-tertiary protein structure due to defect of folding of the peptide chain.Kuru is a prion disease.Other prion diseases are:Creutzfeldt-Jakob diseaseScrapie in sheep.Bovine spongiform encephalopathy in cattle.Note:Prion stands for proteinaceous infectious particle.It contains no nucleic acid. 