<prompt> Niemann Pick disease is due to deficiency ofGalactokinaseGalactosidaseSphingomyelinaseHexosaminidase A  <response>: C Sphinomyelinase EXAMPLES OF SPHINGOLIPIDOSESDiseaseEnzymeDeficiencyLipid AccumulatingClinical SymptomsTay-Sachs diseaseHexosaminidase ACer--Glc--GalNeuAc GalNAcMental retardation, blindness, muscular weakness. GM2 Ganglioside Fabrys diseasea-GalactosidaseCer--Glc--GalGalSkin rash, kidney failure full symptoms only in Globotriaosylceramidemales; X-linked recessive.MetachromaticleukodystrophyArylsulfatase ACer--GalOSO3Mental retardation and psychologic disturbances in adults; demyelination. 3-SulfogalactosylceramideKrabbes diseaseb-GalactosidaseCer GalMental retardation; myelin almost absent. Galactosylceramide Gauchers diseaseb-GlucosidaseCer GlcEnlarged liver and spleen, erosion of long bones, Glucosylceramidemental retardation in infants.Niemann-Pick diseaseSphingomyelinaseCer P--cholineSphingomyelinEnlarged liver and spleen, mental retardation; fatal in early life.Farbers diseaseCeramidaseAcylSphingosineHoarseness, dermatitis, skeletal deformation, mental retardation; fatal in early life. 