<prompt> Cource of a disease process without any intervention is the definition of -Spectrum of diseaseEpidemiology of diseaseNatural history of diseaseIceberg phenonenon  <response>: Ans. is c i.e., Natural history of disease o Natural history of disease signifies the way in which a disease evolves over time from the earliest stage of its prepathogenesis phase to its termination as recovery, disability or death, in the absence of treatment or prevention. 