<prompt> Which of the following NSAID has good tissue penetrability with concentration in synovial fluidKetorolacDiclphenac sodiumSulindacPiroxicam  <response>: Diclofenac sodium 178 - KDT 193-KDT 6th DICLOFENAC - SODIUM - Well absorbed orally 99 protein bound, metabolized and excreted both in urine and bile However it has good tissue penetrability and concentration in synovial fluid is maintained for 3 times long period than in plasma, exerting extended therapeutic action in joints PIROXICAM - It is reversible inhibitor of COX, lowers PG concentration in synovial fluid and inhibits platelet aggregation prolonging bleedmg time KETOROLAC - It is highly plasma protein bound and 6 excreted unchanged in urine major metabolic pathway is glucoronidation SULINDAC - At lower doses is a selective extrarenal PG synthesis inhibitor - does not antagonize the diuretic and anti hypertensive action of thiazides, P blockers and ACE inhibitors or alter renal functions 