<prompt> Which of the following statements about the pathology in Alzheimers disease is not true:Neuritic Plaques are formed of amyloid proteinNeurofibrillary tangles NFT are made of tau proteinNFTs appear extracellularly before intracellular appearanceNumber of NFTs correlates with dementia  <response>: Answer is C NFTs appear extracellularly before intracellular appearance:NFTs are typically seen intracellularly within the soma and proximal dendrites of neurons. Neurofibrillary Tangles NFTs are intracellular accumulations of hyperphosphorylated tau proteins.Neurofibrillary Tangles are Intracellular AccumulationsNeurofibrillary Tangles are intracellular accumulations of hyperphosphorylated microtubule binding protein tau.Paired helical filaments of tau protein NFTs form intracellularly within the soma and proximal dendrites of neurons.These cytoskeletal protein tangles NFTs, initially impede cellular metabolism and axosplasmic transpo leading to impaired synaptic function and eventually to neuronal death.These neurofibrillaty tangles may be seen as extracellular tangles after degeneration of the neuron as evidence of the neuronal cells demiseNeurofibrillary Tangles are intracellular accumulations that may appear extracellularly alter degeneration of neuron neuronal deathHistopathological Hallmarks of Alzheimers DiseaseAmyloid Plaques ExtracellularAmyloid Neuritic Plaques are formed by extracellular accumulation of beta amyloid deposits within the neutropilNeuritic or Senile I3-amyloid plaques are an early histopathological sign of Alzheimers disease that occur rarely in healthy subjectsThe amyloid 13-protein accumulated in single neuritic plaques is toxic to surrounding structures and adjacent neurons.Clinicopathological studies have shown that amyaid burden does not directly correlate with severity or duration of dementia.Neurofibrillary Tangles IntracellularNeurofibrillary tangles arc formed by intracellular accumulation of hyperphosphorylated microtubule binding protein tau.NFTs occur in many neurodegenerative diseases and or a group of diseases called laupathies.These include Frontotemporal dementia, Picks disease etc. The cooccurance of fi-amyloid plaques with NFTs suggests a diagnosis of AD.The NFTs are toxic to the neurons and neurons with NFTs eventually die and degenerate leaving a residual ghost tangle, in the extracellular space reminding of the pyramidal cell body in which it was initially formed.Clinicopathological studies have shown that dementia correlates more strongly with NFTs than with senile plaques 3-amyloid 