<prompt> The eponymus Trisomy 18 isCri du chat syndromePataus syndromeDowns syndromeEdwards syndrome  <response>: D Edwards syndrome EXAMPLES OF CHROMOSOMAL DISORDERSChromosomesResult2n 46, XXNormal female2n 46, XYNormal maleNUMERICAL ABNORMALITIESTriploidy 3n, tetraploidy 4nSpontaneous abortionParthenogenesis 2n from same parentSpontaneous abortionAneuploidy 2n specific chromosome Trisomy 21 47, XY,21Downs syndrome characteristic facies, IQ usually 50, congenital heart disease, reduced life expectancyTrisomy 18 47, XY, 18Edwardssyndrome characteristic skull and facies, frequent malformations of heart, kidney and other organsTrisomy 1347, XY,13Pataus syndrome cleft lip and palate, polydactyly, small head, frequent congenital heart diseaseSex Chromosome Aneuploidies Phenotypically male 47, XXYKlinefelters syndrome infertility, gynaecomastia, small testes47, XYYXYY male usually asymptomatic, often tallPhenotypically female 47, XXXTrisomy X usually asymptomatic, 20 mentally handicapped45, X0Turners syndrome short stature, webbed neck, primary amenorrhoeaSTRUCTURAL CHROMOSOME ABERRATIONSInherited 46, XY, del5pCri du chat syndrome, deletion of short arm of chromosome 545, XY,t14;21Fusion of 14 and 21, no essential chromosomal material lost NORMAL, but balanced carrier of abnormal chromosome46, XY, t14;21Fused 14;21 chromosome has segregated into gamete with normal chromosome 21, and fertilisation has generated trisomy 21 Downs syndromeAcquiredOccur in over 50 of haematological malignancies; also common in other neoplastic cells46, XY, t9,22Philadelphia chromosome chronic myeloid leukaemia46, XY, t2,8 or t8,14 or t8,22Burkitts lymphoma 