<prompt> Tuberous sclerosis is characterized by all ExceptMultiple renal cystArachnoid cystRenal angiolipomaRena cell carcinoma  <response>: Arachnoid cyst 1800, 2607- HI 7th CNS hamartoma can cause, seizure, mental retardation and autism Rena tuberous sclerosis occurs in three forms: renal cysts large and numerous renal angiomyolipoma Bilateral, multiple and renal cell carcinoma MulticentricCharacteristic Triad of Tuberous Sclerosis Epilepsy I seizure Mental retardation Subnormal intelligence Adenoma sebacium facial angiofibroma Tuberous sclerosis TS is an autosomal dominantTSC-1, TSC-2 gene Hamartin and Tuberin formSkin Cutaneous InvolvementNeurological featuresBenign Neoplasms Adenoma sebacium- facial angiofibroma Ash-leaf-shaped hypopigmented macule Shagreen patches - yellowish thickening of skin over lumbo sacral region of back Depigmented nevi Epilepsy, seizureMental retardation Hydrocephalus Presence of subependymal nodule with calcification on neuroimaging is characteristics Rhabdomyoma of myocardium Angiomyoma of kidney liver pancreas adrenal Ependymomas and childhood subependymal giant cell Astrocytoma Clinical features of systemic sclerosis Raynauds phenomenon Myopathy Sclerodactyly Esophageal dysmotility Sub cutaneous calcinosis Pulmonary fibrosis Skin thickening Isolated pulmonary arterial hypertension Melanin deposition Hyperpigmentation CHF Telangiectasia Renal crisis Arthralgia arthritis Third to fifth decade M.F. 1:3 