<prompt> Adult dose of Clozapine is150 mg250 mg300 mg500 mg  <response>: C 300 mg Clozapine: Indicated for reducing risk of recurrent suicidal behavior in patients with Schizophrenia or Schizoaffective disorder in patients who are judged to be at chronic risk to re-experience suicidal behavior Also indicated for treatment-resistant Schizophrenia in patients who fail to respond adequately to standard antipsychotic treatment 12.5 mg PO once daily or 12hr initially; increased daily in increments of 25-50 mgday, if well tolerated, to achieve target dosage of 300-450 mgday by end of 2 weeks On occasion, may have to be increased to 600-900 mgday to obtain acceptable response Maintenance: Generally, patients who respond should continue maintenance treatment on their effective dose beyond the acute episode 