<prompt> Kallmans syndrome is associated with all of the following exceptAmenorrheaExcess stimulation of the HPO axisGenetic mutationAnosmia  <response>: When congenital GnRH deficiency is associated with anosmia or hyposmia an absent or grossly impaired sense of smell, the disorder is known as Kallmann;s syndrome. Two genetic mutations associated with Kallman;s Syndrome : KAL gene - X - linked inheritance Xp22.3 encoding anosmin - 1. Gene encoding FGFR1 Fibroblast growth factor - 1 receptor - autosomal dominant form. Anosmin - 1 is a neural adhesion molecule that promotes migration of GnRH neurons and olfactory neurons, from the olfactory placode into the hypothalamus during embryonic development. REF : Shaw book of gynecology 9th Ed. 