<prompt> Juvenile polyp is aHypeplastic typeHamartomatous polypInflammatoyr polypLymphoid polyp  <response>: Ans: b Hamartomatous polyp Ref: Robbins 7th ed Pg 857 All four options are non neoplastic benign lesions of intestine.Juvenile polyps:Focal hamartomatous malformations involving mucosal epithelium and lamina propriaUsually large rounded glistening lesions with stalks upto 2 cm in length.Usually in children 5 years of age. Around 80 occurs in rectum.Peutz Jeghers polypsHamartomatous polyps involving mucosal epithelium, lamina propria and muscularis mucosa.Peutz Jeghers syndrome - AD disorder. Multiple polyps throughout GIT, mucocutaneous pigmentation.ME: Arborizing network of connective tissue and well developed smooth muscle extends into the polyp and surrounds normal abundant glands lined by normal intestinal epithelium rich in goblet cells.- Increased chance of intussusception- No malignant potential of its own, but increased risk of Ca ovary, lung, pancreas, breast, uterus adenoma malignum, sertoli cell tumors of testes.Bridge:Juvenile polyposis syndrome.AD disorder with risk of adenocarcinoma along with mutations in SMAD4 DPC4 gene encoding TGF betaMutations of STKII LKbl on chromosome 19.Other hamartomatous polyposis1 Cowden syndromeAD, involving all 3 germ layers.Intestinal hamartomatous, facial trichilemmomas, acral keratosis, oral papillomasIncreased chance of thyroid and breast cancerMutation - PTEN gene on chromosome 10.2 Cronkhite Canada syndromeNm hereditary disorder; idiopathicGI hamartomatous polyps ectodermal abnormalities nail atrophy, alopecia 