<prompt> A diagnosed case of psoriasis, taking MTX since last 15 yrs presents with jaundice and abnormal LFT. So, what will be the course of management:Stop Mtx, sta dapsoneMtx cyclosporineStop Mtx, sta steroidsStop Mtx, sta cyclosporine  <response>: Methotrexate is hepatotoxic drug- Therefore, abnormal liver function test jaundice in history- Next step- stop Mtx- Therefore, B is ruled out 3 systemic drugs used in psoriasis1. Mtx Teratogenic, hepatotoxic2. Cyclosporine nephrotoxic-3H HTN, Hyperiglyceridemia , Hyperichosis3. Acitretin- teratogenic, dyslipidemia. In psoriasis systemic steroids are CI Dapsone have no role. 