<prompt> Which of the following is not a pa of Dukes Criteria for infective endocarditis?SplenomegalyFever 100.40FIV drug userBlood culture positive  <response>: Splenomegaly, HemiplegiaBrain abscess and clubbingin SABE are complications of infective endocarditis and are not diagnostic criteria. Splenomegaly: occurs due to development of splenic abscess secondary to embolization of infected vegetations from valvular surface. Choice B and C are minor diagnostic criteria for infective endocarditis. Choice D is a major diagnostic criteria and helps in determining best antibiotic for the condition as well. Duke Criteria for infective endocarditis: Major criteria: 1 Echocardiograpghy: Vegetations nt 2 Blood culture ve: 23 ve for same organisms. For Coxiella burnetti 13 ve. 3 New onset murmur in pre-existing hea disease. Minor criteria: 1 Fever 38oC 2 IV drug abusers and other predisposing conditions 3 Vascular phenomenon like aerial emboli, mycotic aneurysm, SAH, ICH, Janeway lesions 4 Immunological: Roth spots, Osler nodes and P.S.G.N 