<prompt> Most commonly used local anaestheticsDibucaineBupivacainePrilocaineTetracaine  <response>: BupivacaineBupivacaine is 2nd most commonly used local anaesthetic after lidocaineBupivacaine has the highest local tissue irritancy amongst local anaestheticsIt is the most cardiotoxic local anaestheticLevobupivacaine The S- enantiomer of bupivacaine is less cardiotoxic and less prone to cause seizureConcentrations used for bupivacaine are:- Nerve block :0.5, epidural: 0.25-0.5 and spinal: 0.5 Maximum safe dose is 2mgkg without adrenaline and 3mgkg with epinephrineRefer: stoeltings pharmacology and physiology in anaesthetic practice, 5th edition, pg no.294 