<prompt> Vaccine for post splenectomy infection is given against all except :Streptococcus pneumoniaHaemophilia influenzaNeisseria meningitidesE.coli  <response>: Splenectomy : Most serious sequela is overwhelming postsplenectomy infection OPSI, with meningitis, pneumonia, or bacteraemia OPSI is typically caused by polysaccharide-encapsulated organisms, such as Streptococcus pneumoniae, Neisseria meningitidis Hemophilus influenzae When elective splenectomy us planned, vaccination against encapsulated bacteria should be given atleast 2 weeks before surgery If spleen is removed in emergency, vaccination should be given as soon as possible Vaccines should be given for Streptococcus pneumoniae, Hemophilus influenza type B Meningococcus In addition to above given 3 vaccines, annual influenza immunization is also advised as influenza has been implicated as a risk factor for secondary bacterial infections Booster injections of pneumococcal vaccine should be given every 5-6 years Harrison says Routine Chemoprophylaxis with oral penicillin can result in the emergence of drug-resistant strains and is not recommended Ref: Sabiston 20th edition Pgno : 1564 