<prompt> In first step of Heme synthesis, what is required?FeFolateGlycineHistidine  <response>: Stage I: Synthesis of d-Amino Laevulinic Acid d-ALA Intramitochondrial Biosynthesis begins with the condensation of succinyl CoA; active succinate and glycine to form a-amino-b-Ketoadipic acid. the a-amino-b-ketoadipic acid then undergoes decarboxylation to produce d-ALA. Both the reactions are catalyzed by the enzyme d-ALA- synthetase, which requires pyridoxal-P B6-P and Mg as coenzymes. In liver cells, the synthesis occurs in the mitochondrion. Pantothenic acid is also required at this stage is a constituent of CoA-SH.Ref: Textbook of medical biochemistry, MN Chatterji, 8th edition, page no: 541 