<prompt> Thrombotic thrombocytopenic purpura is a syndrome characterized by -Thrombocytosis, anemia, neurologic abnormalities, progressive renal failure and fever.Thrombocytopenia, anemia, neurologic abnormalities, progressive hepatic failure and feverThrombocytosis, anemia neurologic abnormalities, progressive renal failure and feverThrombocytopenia, anemia, neurological abnormalities, progressive renal failure and fever  <response>: Ans. is d i.e., Thrombocytopenia, anemia, neurological abnormalities, progressive renal failureand fever o Thrombotic thrombocytopenic purpura is a disorder of 1vessel wall characterised by lesions in arteriolar walls in various organs that initiate formation of localised platelet thrombi and fibrin deposits at various sites.Clinical pentad of TTPo Microangiopathico Thrombocytopeniao Decreased renalo Disturbed neuro-o FeverHemolyticdue to consumptionfunction duelogical function Anemia Coombs negativeof plateletsdeposits in theCharacteristically HaemolysisRenaland non focal e.g.diffuse Fragmentation of RBCsVasculature. Confusion Increased LDH elevated Aphasia due to intra-vascular Alteration in hemolysis consciousness Testes of coagulation are generally normal :-o Normal PTo Normal APTTo Normal Fibrinogen concentrationo Normal Fibrin degradation products 