<prompt> A new born presented with bloated abdomen sholy after bih with passing of less meconium. A full-thickness biopsy of the rectum was carried out. Which one of the following rectal biopsy findings is most likely to be present?Fibrosis of submucosaHyalinisation of the muscular coatThickened Muscularis propriaLack of ganglion cells  <response>: Delayed passage of less meconium, together with abdominal distension after bih suggests the diagnosis of Hirschprungs disease. Confirmation of diagnosis is based on lack of ganglion cells aganglionosis, in the myentric plexus together with hyperophic nerve fibres in the plexus. Ref: Bailey and Loves Sho Practice of Surgery, 24th Edition, Page 1154 