<prompt> Which of the following is the chief mediator associated with resetting the hypothalamic temperature set point at a higher level, resulting in fever?PGF2 alphaPGE1PGE2PGI2  <response>: Ans. c PGE2Ref: Robbins 9thpg 99The increase in body temperature is caused by prostaglandins that are produced in the vascular and perivascular cells of the hypothalamus.In the hypothalamus, the prostaglandins, especially PGE2, stimulate the production of neurotransmitters that reset the temperature set point at a higher level. 