<prompt> Appearance of which of the following correlates with high levels of hepatitis B virus replication -HBsAgHBeAgAnti HBcIgM Anti HBc  <response>: Ans. is b i.e., HBeAg Serological marker and lab diagnosis Serological markers for HBV infection are1 HBs Ag surface antigen or Australia antigen: It is the first marker which appears in the serum. It is the epidemiological marker for HBV infection.2 HBc Ag core antigen: It is not demonstrable in serum because it is enclosed by HBsAg coat.3 HBe Ag envelope antigen: It is marker of active replication and high injectivity. It is qualitative marker of replication. HBs Ag carrier mothers who are HBe Ag positive almost invariably 90 transmit hepatitis B infection to their offspring, where as HBs Ag carrier mothers with anti HBe rarely 10 to 15 infect their offspring.4 Anti-HBc Ag: It is the first antibody appears in serum. IgM anti-HBc Ag is a marker of acute or recent infection. IgG anti-HBc Ag indicates remote infection.5 Anti-HBs Ag: It is protective antibody. It is the only serological marker present after vaccination. After an infection, its presence indicates recovery and end of period of communicability.6 Anti-HBe Ag: Its presence indicate stopage of replication and low infectivity.7 HBV DNA: It is quantitative marker of HBV replication. HBe Ag - Qualitative marker of replication. HBV DNA - Quantitative marker of replication. HBs AgAnti HBs AgHBe AgAnti HBe AgAnti HBc AgAcute HBV high infectivity- IgMAcute HBV low infectivity- IgMChronic HBV high infectivity- IgMChronic HBV low infectivity- IgMRecovery--IgMImmunized-- 