<prompt> Mediators of inflammation are all except aEURTNFIFNProstaglandinsInterleukinsMyeloperoxidase  <response>: Myeloperoxidase Ref: Robbins 8e p. 57 7e p. 63, 74, 751 Mediators of inflammation :- The vascular and cellular reactions of both acute and chronic inflammation are mediated by chemical factors known as mediator of inflammation. Mediators originate either: - 1. From plasma Complement proteins, Bradykinin 2. From cells Cells derived mediators may he preformed and are stored in secretory granules or they may be synthesized denovo in response to a stimulus. Preformed mediators Histamine, Serotonin, Lysosornal enzymes. Newly synthesized -- Prostaglandins, Leukotrienes, platelet activating factors, nitric oxide, reactive oxygen species,cytokines TNF, IL-I. Myeloperoxidase is not an inflammatory mediator. It is an enzyme of neutrophil which catalyzes the conversion of CI-, Br. and and SCN to the corresponding acids HOC1, HOBr etc.. These acids are potent oxidants and help in destroying the invading organisms. Mediator Source Vascular Vascu leakage Chemotaxis Other Histamine serotonin Mast cell, platelets - Bradykinin Plasma substrate - Pain C3,, Plasma protein Liver Opsonic fragment C5, Leucocyte adhesion Prostaglandins Mast cells from membrane phospholipid Potentiate other mediators - Vasodilation, Pain, Fever Leukotriene BP Leucocytes - Leucocyte adhesion activation LenkotrieneQ C4, 14, E4 Leucocyte Mast cells Bronchocuntriction, Vasoconstriction Oxygen Metabolites Leucocytes - Endothelial damage, Tissue damage PM Leucocytes mast cells Bronchoconstriction Leucocyte priming IL-le and TNF Q Macrophages, others - Acute phase reactions, Endothelial activation Chentokines Leucocytes, others - Leucocyte activation Nitric oxide Macrophages Vasodilation cytotoxicity endothelium 