<prompt> Multiple sclerosis is characterized by a loss of which lipidsPhospholipids and ceramideSphingolipids and ceramideSphingolipids and gangliosidesPhospholipids and sphingolipids  <response>: Phospholipids and sphingolipids Ceramide is an impoant signaling molecule for apoptosis and is a precursor for glycosphingolipids and gangliosides. Sphingolipids and phospholipids are structural lipids in membranes. Multiple sclerosis is a demyelinating disease in which both phospholipid and sphingolipid levels are decreased, unlike lipid storage diseases, which affect sphingolipid levels. Ref : 