<prompt> Burkitts lymphoma shows which translocation?8:149:2211:1414:18  <response>: ANSWER: A 8: 14REF: Wintrobes clinical hematology 12th edition page 1604.1605, LymphomaSee APPENDIX-29 below for TRANSLOCATION APPENDIX - 29TranslocationThe International System for Human Cytogenetic Nomenclature ISCN is used to denote a translocation between chromosomes. The designation t A; B pi; q2 is used to denote a translocation between chromosome A and chromosome B. The information in the second set of parentheses, when given, gives the precise location within the chromosome for chromosomes A and B respectively--with p indicating the short arm of the chromosome, q indicating the long arm, and the numbers after p or q refers to regions, bands and sub bands seen when staining the chromosome with a staining dyeTranslocationAssociated diseasesFused genesproteinsFirstSecondt 8; 14 q24; q32Burkitts lymphomac-myc on chromosome 8, gives the fusion protein lymphocyte-proliferative abilityIGH immunoglobulin heavy locus on chromosome 14, induces massive transcription of fusion proteintll;14 ql3;q32Mantle cell lymphomacyclin D1 on chromosome 11, gives fusion protein cell- proliferative abilityIGH Immunoglobulin heavy locus on chromosome 14, induces massive transcription of fusion proteint14; 18 fq32;q21Follicular lymphomaIGH immunoglobulin heavy locus on chromosome 14, induces massive transcription of fusion proteinBcl-2 on chromosome 18, gives fusion protein anti- apoptotic abilitiest11; 18 q21; q21MALT lymphomas t10; various q11; variousPapillary thyroid cancerRET proto-oncogene on chromosome 10PTC Papillary Thyroid Cancer- Placeholder for any of several other genesproteinst2: 3 ql3; p25Follicular thyroid cancerPAX8 - paired box gene 8 on chromosome 2PPARyl peroxisome proliferator-activated receptor y 1 on chromosome 3t8 ;21 q22; q22Acute myeloblastic leukemia with maturationETO on chromosome 8AML1 on chromosome 21t9;22 q34;qllPhiladelphiachromosomeChronic myelogenous leukemia CML, acute lymphoblastic leukemia ALLAbl1 gene on chromosome 9BCR breakpoint cluster region on chromosome 22t15; 17Acute promyelocytic leukemiaPML protein on chromosome 15RAR-tr on chromosome 17t12; 15 pl3; q25Acute myeloid leukemia, congenital fibrosarcoma, secretory breast carcinomaTEL on chromosome 12TrkC receptor on chromosome 15t9; 12 p24; pl3CML, ALLJAK on chromosome 9TEL on chromosome 12t12; 21 pl2; q22ALLTEL on chromosome 12AML1 on chromosome 21tl; 11 q42.1; ql4.3Schizophrenia t2; 5 p23; q35Anaplastic large cell lymphoma tll; 22 q24; qll.2- 12Ewings sarcoma t17; 22Dermatofibrosarcoma protuberans DFSP tl; 12 q21; pl3Acute myelogenous leukemia tX; IS pll.2- qll.2Synovial sarcoma tl; 19 qlO; plOOligodendroglioma and oligoastrocytoma 