<prompt> False about lymphoma in AIDS patientsIntranodalExtranodalHighly aggressiveLess responsive to treatment  <response>: Ans: d less respon.... Ref: Harrison 17th ed p. 1188, 1189The treatment response for lymphoma in AIDS patient is as high as 72Lymphoma in AIDSClinical features High grade Lymphadenopathy Extranodal involvement- most common site is CNS Disseminated diseaseThree main categories of lymphoma are seen in patients with HIV infection:- Grade III or IV immunoblastic lymphoma Burkitf s lymphoma Primary CNS lymphomai Immunoblastic lymphoma 60 of the cases of lymphoma in patients with AIDS. High grade Seen in older patients One variant - body cavity lymphoma lymphomatous pleural, pericardial, peritoneal effusions in absence of intranodal or extranodal masses. HHV-8 DNA sequences in these malignant cellsii Burkitts lymphoma small noncleaved cell lymphoma 20 of cases Seen in 10-19 years old Characteristic c-myc translocations from chromosome 8 to chromosome 14 or 22 Only 50 of HIV associated Burkitts lymphoma are EB V-positive.iii Primary CNS lymphoma 20 of cases No age predilection EBV positive Seen in later stage of HIV, so poorer prognosis.Response to treatment is as high 72.Note:-Multicentric Castlemans disease is a HHV-8 associated lymphoproliferative disorder.Lymph node biopsies show onion skin appearance hyaline vascular 