<prompt> Rain drop skull appearance is seenMultiple myelomaEosinophilic granulomaPagets diseaseSickle cell anemia  <response>: Ref. Grainger and Allisons Diagnostic Radiology. Page. 409 MULTIPLE MYELOMA RAIN DROP APPERANCE PUNCHED OUT LESIONS IN THE SKULLImp radiological features Expansile osteolytic lesions associated with soft tissue massesDiffuse osteolysis or generalised osteoporosisPeriosteal new bone formation is characteristically absentSpine diffuse lytic lesions 