<prompt> Orotic aciduria is due to deficiency of-DecarboxylaseIsomeraseTyrosinaseHomogentisate oxidase  <response>: Oroticaciduria is a rare, Autosomal recessive disorder. It is the most common metabolic error in Pyrimidine Synthesis. OP Orotate Phospho Ribosyl Transferase Decarboxylase are bifunctional enzymes in pyrimidine synthesis. There are two types of Orotic acidurias: Type I : Both enzymes deficient i.e. OPOrotate Phosphoribosyl Transferase and OMP Decarboxylaseit is a bifunctional enzyme Type II - Only one enzyme deficient mostly OMP decarboxylase 