<prompt> Which disorder is most likely associated with erythroid hyperplasia in the bone marrow?Anemia of chronic diseaseThalassemia minor7 to 10 days after a GI bleedIron deficiency  <response>: Erythroid hyperplasia in the bone marrow is a response of the erythroid series to erythropoietin stimulation. These stimuli include hypoxemia e.g., chronic, obstructive pulmonary disease, anemia less than 7 gm dl, a left-shifted oxygen dissociation curve e.g., carbon monoxide poisoning, a bleed more than 5 to 7 days, and testosterone. Anemia of chronic disease, thalassemia minor, and iron deficiency have problems in hemoglobin synthesis, so these would not be expected to have a reticulocyte response. In chronic renal disease, there is a decreased concentration of erythropoietin, which results in a normocytic anemia and no reticulocyte response. Ref - Harrisons internal medicine 20e pg 391, 391f, 684, 696 