<prompt> A 19-year-old female presented with fever, cough shoness of breath and diffuse chest pain. She gave a history of reduced water intake since yesterday. On examination, Hypeension Tachycardia SpO2 is 80 on room air BL wheezing in lower lung zones Lab findings revealed anemia, leukocytosis, reticulocytosis, thrombocytosis, increased serum bilirubin. Peripheral blood smear Chest x-ray CT scan of chest Which is the most appropriate therapy in the above condition: -HydroxyureaSildenafilIV ceftriaxoneStreptokinase  <response>: This is a case of acute chest syndrome in a patient of sickle cell anemia. Presents as acute fever, cough, chest pain and wheezing in a background of sickle cell anemia. X-ray and CT are suggestive of subsegmental atelectasis of right lower lobe. Management: - Transfusion to maintain hematocrit 30 Emergency exchange transfusion Hydroxyurea is the mainstay. 