<prompt> Which is not the action of TGF -Anti -inflammatoryProliferation of fibrous tissueAnaphylaxisInhibition of metalloproteinases  <response>: Transforming Growth factor beta:Transforming growth factor-βTGF-β is the most important cytokine for the synthesis and deposition of connective tissue proteins.It is produced by most of the cells in granulation tissue, including alternatively activated macrophages.The levels of TGF-β in tissues are primarily regulated not by the transcription of the gene but by the post-transcriptional activation of latent TGF-β, the rate of secretion of the active molecule, and factors in the ECM, notably integrins, that enhance or diminish TGF-β activity.TGF-β stimulates fibroblast migration and proliferation, increased synthesis of collagen and fibronectin, and decreased degradation of ECM due to inhibition of metalloproteinases.TGF-β is involved not only in scar formation after injury but also in the development of fibrosis in lung, liver, and kidneys that follows chronic inflammation.TGF-β is also an anti-inflammatory cytokine that serves to limit and terminate inflammatory responses. It does this by inhibiting lymphocyte proliferation and the activity of other leukocytes. 