<prompt> Metaclopramide all are true except -Increase gastric emptyingD2-agonistActs on CTZLong term use can cause parkinsonism, galactorrhoea and gynaecomastia  <response>: Ans. is b i.e., D2-agonist o Metaclopramide is D2-antagonist not agonist.Metoclopramideo Metoclopramide is aprokinetic drug -Promotes gastrointestinal transit and speed gastric emptying by enhancing coordinated propulsive motility.o It has more prominent effect on upper GIT - increases gastric peristalsis, while relaxing the pylorus and the first part of duodenum - speed gastric emptying. Tone of lower esophageal sphincter LES is increased and gastroesophageal reflux opposed.o It has less prominent effect on lower GIT - increases intestinal motility to some extent, but has no significant action on colonic motility,o Metoclopramide is an effective antiemetic.o Mechanism of action.1. 5-HT4 agonism - stimulation of 5-HT4 receptor in GIT enhances the release of ACH from myenteric plexus - Main prokinetic action of metoclopropamide is due to this action.2. D2 antagonism - Blockade of D2 receptor in CTZ is mainly responsible for antiemetic effect. D2 receptor blockade in GIT is responsible for some prokinetic action also.3. 5-HT3 antagonism - At higher concentration.o Uses - As an antiemetic, as a gastrokinetic in GERD, in dyspepsia.o Adverse effects - Sedation, dizziness, loose stools, muscle dystonia especially in children are the main side effects. D2 - blocking action may cause extrapyramidal symptoms Akathsia, Parkinsonism and hyperprolactinemia galactorrhea, gynacomastia. 