<prompt> Low TIBC is seen in:Anemia of chronic diseaseIron deficiency anemiaFanconi anemiaAplastic anemia  <response>: Ans. a Anemia of chronic diseaseRef: Robbins pathology 9th ed. 652In anemia of chronic disease, response to inflammatory cytokines, increasingly IL-6 the liver produces increased amounts of hepcidin.Hepcidin, in turn, causes increased internalization of ferroportin molecules on cell membranes which prevents the release from iron stores.Since stores of iron are un-utilized, serum ferritin is increased. TIBC levels are the inverse of serum ferritin.Low serum iron and ferritin levels with an elevated TIBC are diagnostic of iron deficiency. 