<prompt> Which of the following drugs is recommended for the treatment of heparin induced thrombocytopenia -AbciximabLepirudinWarfarinAlteplase  <response>: Ans. is b i.e., Lepirudin Heparin induced thrombocytopenia HIT o Heparin induced thrombocytopenia is an impoant adverse effect of heparin administration, usually caused by unfractionated heparin, but may also be seen with the use of low molecular weight heparin LMWH. o HIT may be of two types : Type 1 Non-immune mediated :- It is mild and heparin may be continued. Type 2 Immune mediated :- It is due to formation of antibodies against platelets. Paradoxical thrombosis can occur. Heparin must be discontinued immediately. Warfarin and LMW are contraindicated. Lepirudin a direct thrombin inhibitor is anticoagulant of choice. Alternatives are danaparoid, hirudin and Argatroban. 