<prompt> Which of the following drugs is not used in treatment of bird flu?OseltamivirRibavirinZanamivirPeramivir  <response>: Ans. b. Ribavirin Ref: Harrison 19ep1214; Goodman Gilman 12ep1609, 1615; Katzung 12ep886, 887; KDT 7e p798, 804, 6e p777Oral ribavirin is used for chronic HCV infection, not the bird flu.Oral ribavirin in combination with injected pegIFN alfa-2A or -2B has become standard treatment for chronic HCV infection, -- Goodman Gilman 12e p1615Ribavirin is a nucleoside analogue with activity against influenza A and B viruses in vitro. Its efficacy against influenza when administered as an aerosol is reportedly variable, and it is ineffective when administered orally. Its efficacy in the treatment of influenza A or B has not been established. -- Harrison 19e p1214Ribavirin is used primarily to treat hepatitis C, viral hemorrhagic fevers and RSV.The neuraminidase inhibitor peramivir, a cyclopentane analog, has activity against both influenza A and B viruses. Peramivir received temporary emergency use authorization by FDA for intravenous administration in November 2009 due to the HINI pandemic. -- Katzung 12e p887Specific Antiviral Therapy for influenzaNeuraminidase inhibitors zanamivir, oseltamivir peramivir are used for both influenza A BQAmantadine rimantadine are used for influenza AQOseltamivir DOC for bird flu H5N1Q Treatment of uncomplicated influenza A or B in healthy adults.Zanamivir Administered by inhalational routeQ Treatment of uncomplicated influenza A or B in healthy adultsQ.Peramivir Administered IVQ Activity against both influenza A B virusesQLaninamivir Long acting neuraminidase inhibitorQ Effective against oseltamivir resistant virusQAmantadine Active against influenza A onlyQRimantadine Longer acting than Amantadine, active against influenza A onlyQDrug of Choice in Viral DiseasesDiseaseDrug of Choice Viral hemorrhagic fever Lass virus, Rift valley fever, Congo Crimean hemorrhagic fever. Hanta virus Respiratory syncytial virus in high risk patients MeaslesRibavirinQ Seasonal influenza Avian influenza bird fluOseltamivirQ Oseltamivir resistant influenzaZanamivirQ Prion diseaseFlupirtineQ Herpes simplex VaricellaAcyclovirQ Acute herpes zosterValacyclovirQ Cytomegalovirus retinitisGancicyclovirQ 