<prompt> Drug of choice for central diabetes insipidus is:DesmopressinLeuprolideThiazide diureticsInsulin  <response>: Ans. A DesmopressinRef: CMDT 2010996Desmopressin is treatment of choice for central diabetes insipidus.It acts selectively at V2 receptors to increase urine concentration and decrease urine flow in a dose-dependent manner.It is also more resistant to degradation than AVP and has a three to fourfold longer duration of action.Desmopressin can be given by IV or SC injection, nasal inhalation, or oral tablet. 