<prompt> Isolated rise in aPTT is seen in?Von Willibrands diseaseFactor 7 deficiencyVitamin K deficiencyAnti phospholipid antibodies  <response>: Isolated rise of APTT are seen in APTT measures the activity of the intrinsic and common pathways of coagulation CAUSES Lupus anti-coagulant anti-phospholipid syndrome Heparin exposure Haemophilia A and B Factor VIII and IX deficiency respectively Factor XII deficiency Factor XI deficiency Contact factor deficiency e.g. pre-kallikrein not clinically impoant Aefactual incorrect amount of blood in the tube Ref Robbins 9e pg 54 