<prompt> True about HUS -ThrombocytopeniaSchistocytes seen in peripheral bloodCaused by E coliAll  <response>: Ans. is a i.e., Thrombocytopenia; b i.e., Schistocytes seen in peripheral blood; c i.e., Caused by E. coli Following information have been added in 811 of Robbins o Hemolytic uremic syndrome is classified into two types: Typical epidemic, classical, diarrhea-positive HUS -- occurs in children. HUS described in previous explanations is typical HUS Atypical non-epidemic, diarrhea-negative -- occurs mainly in adults. Most of the patients have deficiency of complement regulatory proteins, factor H most common, Factor I, and CD46 membrane cofactor protein. Other conditions that cause atypical HUS are antiphospholipid syndrome, pregnancy or postpaum period, systemic sclerosis, malignant hypeension, chemotherapeutic mitomycin, cyclosporine, cisplatin, gemcitabine, irradiation to kidney. o HUS patients with neurological symptoms has normal ADAMTS 13 which distinguish it from TTP in which ADAMTS 13 is deficient. o Chronic disease of kidney is confined to atypical HUS or TTP not in typical HUS and kidney may show reduplication splitting of basement membrane double contours or tram tracks and onion-skinning of vessels. 