<prompt> Folinic acid is specifically indicated forAnaemia associated with renal failurePernicious anaemiaCounteracting toxicity of high dose methotrexateProphylaxis of neural tube defect in the offspring of women receiving anticonvulsant medication  <response>: Methotrexate toxicity:- Folinic acid Leucovorin, citrovorum factor, 5-formyl-THFA is an active coenzyme form which does not need to be reduced by DHFRase before it can act. Methotrexate is a DHFRase inhibitor; its toxicity is not counteracted by folic acid, but antagonized by folinic acid. Ref:- kd tripathi; pg num:-611 