<prompt> Which anaesthetic agent does not affect blood flow to liver?HalothaneIsofluraneEnfluraneSevoflurane  <response>: - Total hepatic blood flow hepatic aery blood flow poal blood flow- Liver maintains total hepatic blood flow by autoregulation- All inhalational anesthetic agents disrupt dual blood supply of liver - Halothane completely disrupts dual blood supply- Halothane - acyl halide metabolite - Auto immune hepatitis - Enflurane also affects liver blood flow- Isoflurane, sevoflurane desflurane - maintain hepatic blood flow - Desflurane - Best in maintaining liver blood flow - Not metabolized by liver and kidney - Sevoflurane - Higher MAC- Decreases little amount of hepatic blood flow 