<prompt> Treatment of tetanus isClindamycinDoxycyclineMetronidazolePenicillin  <response>: If possible, the entry wound should be identified, cleaned, and debrided of necrotic material in order to remove anaerobic foci of infection and prevent fuher toxin production. Metronidazole 400 mg rectally or 500 mg IV every 6 h for 7 days is the preferred antibiotic. An alternative is penicillin 100,000-200,000 IUkg per day, although this drug theoretically may exacerbate spasms. Harrisons Principles of internal medicine,20th edition, page 1199 