<prompt> A 24-year-old unmarried women has multiple nodular, cystic, pustular and comedonic lesions on face, upper back and shoulders for 2 years. The drug of choice for her treatment would be:AcitretinIsotretinoinDoxycyclineAzithromycin  <response>: Ans. b. IsotretinoinIndicators of isotretinoinIsotretinoinTargets all pathogenic mechanisms of Acne IndicationsNodulocystic acne QSevere, refractory AcneAcne fulminansAcne conglobataContraindicationsWomen of reproductive age groupHypertriglyceridemiaDyslipidemiaDosage0.5-1 mgkgday up to a cumulative dose of 120- 150 mgkgSevere nodulo cystic acneSevere acne variants like acne fulminans, pyoderma facialeFailure of conventional therapyModerate to severe acne frequently relapsingAcne severe enough to result in psychological distressInflammatory acne 