<prompt> Recent drug for metastatic hormone receptorand HER-2 - metastatic breast cancer :PalbociclibIpataseibHerceptinBuparlisib  <response>: Palbociclib is a recent drug for metastatic hormone receptorand HER-2 - breast cancer. It works by inhibiting Cyclin-dependent kinase 46. Other examples of this class of drug includes: Ribociclib, Abemaciclib. These drugs are used along with letrozole aromatase inhibitor andor fulvestrant selective estrogen-receptor downregulator HerceptinTrastuzumabis used in Her-2 neu positive breast cancer. Ipataseib is an AKT Protein kinase B inhibitor used in metastatic triple-negative breast cancer. Buparlisib is a Phophatidyl-inositol 3 kinase PI3k inhibitor which is still in trial stages for treatment of metastatic breast carcinoma 