<prompt> Sirolimus is more likely than cyclosporine to cause :HypertensionOsteoporosisRenal insufficiencyThrombocytopenia  <response>: Cyclosporine and tacrolimus cause nephrotoxicity as an adverse effect.Sirolimus rapamycin results in bone marrow suppression and thus may cause anemia, thrombocytopenia and leukopenia. 