<prompt> Tangiers disease is characterized by:Low or absence of HDLLow LDL concentrationRaised chylomicronsDeficiency of LPL  <response>: Tangiers disease Familial alpha-lipoprotein deficiencyHypo alpha lipoproteinemia. Defect in ABC-A 1 receptors which helps in giving cholesterol from peripheral tissue to HDL. HDL is not properly formed- HDL Other lipoproteins are normal. Apo A1. Cholesterol accumulates in reticulo endothelial system CF : Peripheral neuropathy, Hepatosplenomegaly Large orange yellow tonsils. 