<prompt> Which of the following glycosaminoglycans does not contain Uronic acid?Hyaluronic acidKeratan SulfateDermatan sulfateHeparin  <response>: Keratan sulfate: Seen in costal cailages, cornea, nucleus pulposus and wall of the aoaComp: No URONIC ACIDHyaluronic acid: Sulphate free, not covalently bound to protein, seen in bacteriasForms the ground substance of connective tissue; Seen in the vitreous humor of eye and synol fluidComp: N-acetyl glucosamine glucuronic acidDermatan sulfate: N-acetyl galactosamine L-iduronic acidWeak anticoagulant propey. Also called b-heparinHeparin: Anticoagulant and lipid clearing agent. synthesis in the liver. Produced by mast cellsnote-intracellular GAGAlso found in lungs, thymus, spleen, skin. A-glycosidic linkages seenComp: GlcN glcUAIDUA5-epimerase conves GlcUA to IDUANH2 at C2, OH at C6, GlcUA, and IDUA are sulfatedIt occurs in combination with proteinsserine and gly proteoglycans Harpers Biochemistry; 30th edition 