<prompt> Methemoglobinemia is associated with:AicainePrilocaineBupivacaineMepivacaine  <response>: A unique systemic side effect associated with a specific local anesthetic is the development of methemoglobinemia after the administration of large doses of prilocaine. In general, 600-mg doses are required for the development of clinically significant levels of methemoglobinemia in adults. Ref: Millers anesthesia-7th ed, Chapter 30. 