<prompt> In which of the following disorders, administration of barbiturates is contraindicated?Anxiety disordersAcute intermittent porphyriaKernicterusRefractory status epilepticus  <response>: Ans. B Acute intermittent porphyriaRef: KDT 8e p427Barbiturates induce the rate limiting enzyme d-aminolaevulanic acid synthase in porphyrin synthesis. This increased synthesis of porphyrins can precipitate acute attack of AIP. 