<prompt> All of the following are features of Zollinger Ellison syndrome except -Intractable peptic ulcersSevere diarrhoeaBeta cell tumours of the pancreasVery high acid output  <response>: Ans. is c i.e., Beta cell tumours of pancrease Gastrinoma or Zollinger Ellison syndrome is a non b cell neuroendocrine tumour of the pancreasIt secretes gastrinPathophysiology of GastrinomaGastrinoma - Increase secretion of gastrin - marked gastric acid hypersecretion - peptic ulcerPancreatic Neuroendocrine Tumors Gastrinoma non b cell tumourGastrinDuodenum 70 Pancreas 25 other sites 560-90Pain 79-100Diarrhoea 30-73GERD 30-35Peptic ulcerInsulinoma b cell tumourInsulinPancreas 99 Insulinomas are distributed equally on head body and tail of pancrease 10Symptoms of hypoglycemiaSymptoms relieve on administration of glucoseVIPOMA Vomer-Morrison syndrome,pancreatic cholera,WDHAVasoactive intestinalpeptidePancreas 9040-70Watery diarrhoea 90-100Hypokalemia 80-100HypochlorhydriaDehydration 83Flushing 20GlucagonomaGlucagonPancreas 100 usually occurs singly in pancreatic tail50-80Dermatitis migratory necrolytic erythema 67-90Glucose intolerance 40-90Weight loss 66 to 96Anemia 33-85Diarrhoea 15-29Thromboembolism 