<prompt> A 22 years old woman presented with recent onset of hirsutism and voice change. What is the best test to be done?Urine 17 ketosteroidsBlood FSH and LH levelsBlood testosterone levelsBlood thyroxine and TSH levels  <response>: Ans. C. Blood testosterone levelsa. Testosterone is bound to serum hormone binding globulins SHBG.b. SHBG production in liver is inhibited by androgens and increased by Oestrogen and thyroid hormone.c. Low Oestrogen and thyroid hormone cause fall in SHBG level and this results in some testosterone being released in blood circulation as free T which causes hirsutism.d. Testosterone level 6nmoll is seen in ovarian tumor and hyperthecosis.e. In PCOD, LH level exceeds 10ul;T2.5nmolL and SHBG30nmoll. 