<prompt> The pharmacokinetic propeies of a new drug are being studied in normal volunteers during phase I clinical trials. The volume of distribution and clearance determined in the first subject are 40 L and 2.0 Lhour, respectively. The half-life of the drug in this subject is approximately?261421  <response>: The half-life of a drug can be determined using the following equation: t12 0.693 x VdCl 0.693 X 402 13.86 14. Ref: Buxton I.L., Benet L.Z. 2011. Chapter 2. Pharmacokinetics: The Dynamics of Drug Absorption, Distribution, Metabolism, and Elimination. In L.L. Brunton, B.A. Chabner, B.C. Knollmann Eds, Goodman Gilmans The Pharmacological Basis of Therapeutics, 12e. 