<prompt> Granular layer is absent in:Ichtyosis vugarisX linked ichthyosisEpidermolytic hyper keratosisLamellar ichthyosis  <response>: A i.e. Ichtyosis vugaris Icthyosis vulgaris - Icthyosis vulgaris is autosomal dominant disorderQ, occurring due to reduced or absence of filaggrin protein and granular layerQ. It presents with dry scaly skin resembling fish reptile or crocodile skin Ka sauroderma. AD means one parent should also manifest disease. It is a congenital condition which is not present at bih but develops during first year of life. - Diy looking large mosaic like scales most commonly over anterior extensor surface of legs. Major flexors axillae, groins, popliteal cubital fossa are always and face is usually spared; though cheeks forehead may be rarely involved. Condition improves in humid summers and deteriorates in winter. It may be associated with atopic diathesis, keratosis pilaris, hyper linear exaggerated palm sole creases, and occasionally, keratoderma. 