<prompt> Ataxia telangiectasia is associated with all of the following exceptRecurrent sinopulmonary infectionsLymphatic reticular malignanciesIncreased fraction of IgA immunoglobulinsInsulin resistance  <response>: Although B lymphocytic development is normal most patients are deficient in serum IgA and IgEAtaxia telangiectasia:An autosomal recessive genetic disorderMutation of AT gene located on chromosome 1111q 22-33A defect in DNA repair, increased number of chromosomal breaksAlfa-fetoprotein and carcinoembryonic antigen levels are increasedManifestations are:AtaxiaOculocutaneous telangiectasiasMalignanciesHodgkins lymphomaAcute leukemiaImmunodeficiency Endocrinal Ref: Harrison; 18e; p3344 