<prompt> In which of the following condition there are congenital anomalies of the middle ear?Tuner syndromeDown syndromeKlinefelter syndromeAlpo syndrome  <response>: Congenital anomalies of the middle ear may be associated with other general congenital deformities. There are a number of branchial arch syndromes, e.g. Pierre Robins craniofacial dysostosis, Downs and Treacher Collins syndromes. If there is an external ear abnormality it should raise suspicion of an underlying middle ear deformity. Middle ear deformity can be assessed by high-resolution CT scanning, if the inner ear is normal, reconstructive surgery of the middle ear can be successful. 