<prompt> Patient with hemophilia A have bleeding disorder because of:Lack of platelet aggregationLack of reaction accelerator during activation of factor X in coagulation cascadeNeutralization of antithrombin IIIRelease of Thromboxane A2  <response>: Hemophilia A - X- linked disorder -90 cases- deficiency of factor 8 -10 cases - functional defect of factor 8 -Intrinsic Pathway affected -Factor VIIIa complex is the most impoant activator of factor X required for conversion of prothrombin to thrombin. -In symptomatic cases there is a tendency toward easy bruising and massive hemorrhage after trauma or operative procedures 