<prompt> A 4-year-old child presented with a palpable abdominal mass in the right flank region which was painless and slowly increasing in size along with some episodes of fever and hematuria. On examination, hypeension was noted. CT scan of the abdomen was done. The patient was operated and the mass was resected. The gross specimen and the HPE examination are given below. All of the following drugs are approved for the above condition except: -DoxorubicinDactinomycinVincristineBleomycin  <response>: This is a case of Wilms tumour. Wilms tumor is often associated with mutations in the WT1 gene, CTNNB1 gene, or AMER1 gene CT image shows a mass in the right kidney. Gross nephrectomy specimen shows a Wilms tumor pushing the normal renal parenchyma to the side. HPE image shows the characteristic three components: Malignant small round blue cells 2x the size of resting lymphocyte blastema component Tubular structuresrosettes epithelial component Loose paucicellular stroma with spindle cells stromal component The median age at diagnosis of this kidney tumor see the image below is approximately 3.5 years. Clinical findings include the following: Asymptomatic abdominal mass in 80 of children at presentation Abdominal pain or hematuria 25 Urinary tract infection and varicocele less common Hypeension, gross hematuria, and fever 5-30 Hypotension, anemia, and fever from hemorrhage into the tumor; uncommon Respiratory symptoms related to lung metastases in patients with advanced disease; rare Drugs approved for chemotherapy are: - Cyclophosphamide Vincristine Doxorubicin Dactinomycin 