<prompt> The clinical sign of hyaline membrane disease generally first appearsIn the first 6 hours of lifeBetween 12 and 24 hours of lifeBetween 36 and 48 hours of lifeAfter 48 hours of lilfe  <response>: Clinical features of HMD Respiratory distress occurs within the first 6 hours of life.Clinical features include -Tachypnea o Decreased air entry a BP may falla Retraction o Fatigue o Oliguria If untreatedGrunting o Pollor o IleusCyanosis Mixed respiratory metabolic acidosis 