<prompt> Most common type of Hodgkins lymphoma :Nodular sclerosisMixed cellularityLymphocyte predominantLymphocyte depleted  <response>: Ans. a Nodular sclerosisRef. Robbins pathology 9th ed. 607-610types of Hodgkins lymphomaNodular sclerosisIs the most common subtype and is composed of large tumor nodules showing scattered lacunar classical RS cells set in a background of reactive lymphocytes, eosinophils and plasma cells with varying degrees of collagen fibrosissclerosisMixed cellularityMost common format seen in India; also the commonest in HIV positive patients. Biopsy shows classic. Reed Sternberg cells Lymphocyte depletedIs a rare subtype, composed of large numbers of often pleomorphic RS cells with only a few reactive lymphocytes which may easily be confused with diffuse large cell lymphoma. Many cases previously classified within this category would now be reclassified under anaplastic large cell lymphomaLymphocyte-richGoodbest prognosisNodular lymphocytic predominantExpresses CD20 and is classified as considered a form of non- classical Hodgkins.Microscopic examination of the lymph node biopsy reveals complete or partial effacement of the lymph node architecture by scattered large malignant cells known as Reed-Sternberg cells RSC admixed within a reactive cell infiltrate composed of variable proportions of lymphocytes, histiocytes, eosinophils, and plasma cells.The Reed-Sternberg cells are identified as large often bi-nucleated cells with prominent nucleoli and an unusual CD45-, CD30, CD 15- immunophenotype. In approximately 50 of cases, the Reed-Sternberg cells are infected by the Epstein-Barr virus.Characteristics of classic Reed-Sternberg cells include large size 20-50 micrometers, abundant, amphophilic, finely granularhomogeneous cytoplasm; two mirror- image nuclei owl eyes each with an eosinophilic nucleolus and a thick nuclear membrane chromatin is distributed close to the nuclear membrane. 