<prompt> Commonest site of lytic lesion in multiple myeloma isVeebral columnFemurClaviclePelvis  <response>: The bones most commonly affected in multiple myeloma in descending order of frequency are veebral coloumn,ribs, skull, pelvis, femur, clavicle and scapula Ref:Robbins and Cotran Pathologic basis of disease.South Asia Edition volume 1.Page no.599 