<prompt> Most common complication of modified ECTIntracerebellar BleedFracture spineBody acheAmnesia  <response>: Electro convulsive therapy seizure increases production of brain derived neurotrophic factor BDNFQ. Madsen proposed generation of new neurons in the hippocampus may be an impoant neurobiological element underlying the clinical effects of ECT. ECT is most commonly indicated -85 of all ECT and most effective in treatment of major depression with psychosis delusions or suicidal tendencyQ. ECT is indicated in psychotic delusional depressionQ because nihilistic delusions may induce suicidal tendency, whereas ECT is not indicated in neurotic depression dysthynia, cyclothymiaQ. ECT may be useful in MDP bipolar in decreasing duration of depressive episode. ECT is not or less useful in chronic conditions like chronic schizophrenia with negativ symptoms espQ. Use of ECT is not the first line choice of treatment in mania schizophrenia lithium anti psychotics are mainstay of treatment. Panic disorder is also treated with drugs not ECT. REF : Oxford text book of psychiatry 3rd Ed. 