<prompt> Main cytokine involved in erythema nodosum leprosum reaction isIL 2Interferon gammaTumour necrosis factor alphaMacrophage colony stimulating factor  <response>: Erythema nodosum leprosum rection is type II lepra rection .In this modules over skin are seen This is a type III hypersensitivity reaction . Main cytokine involve is TNF -alpha DOC - gluco-coicoids 