<prompt> Holt-Oram syndrome is characterized by?ASDVSDTGATAPVC  <response>: Holt-Oram syndrome: - Autosomal dominant disorder - Characterized by - skeletal abnormalities of hands and arms like: Hypoplastic absent thumbs, radii Triphalangism Phocomelia - Cardiac anomalies ASD 1st degree hea block TRIPHALANGISM phacomelia 