<prompt> A 40-year-old male complains of weakness, weight loss, and abdominal pain. On examination, the patient has diffuse hyperpigmentation and a palpable liver edge. Polyahritis of the wrist and hips is also noted. FBS is 185 mgdl. The most likely diagnosis is?Type I DMPancreatic carcinomaAddisons diseaseHemochromatosis  <response>: Hemochromatosis Hemochromatosis is a disorder of iron storage that results in deposition of iron in parenchymal cells. The liver isusually enlarged, and excessive skin pigmentation is present in 90 of symptomatic patients at the time of diagnosis. Diabetes occurs secondary to direct damage of the pancreas by iron deposition. Ahropathy develops in 25 to 50 of cases. Other diagnoses listed could not explain all the manifestations of this patients disease process. Addisons disease can cause weight loss and hyperpigmentation but does not affect the liver or joints; it is associated with hypoglycemia rather than diabetes mellitus. 