<prompt> Most potent stimulus for bile secretion isCholecystokininGastrinSecretinBile acid  <response>: Bile is secreted in two stages by the liver: 1 The initial portion is secreted by the principal functional cells of the liver, the hepatocytes; this initial secretion contains large amounts of bile acids, cholesterol, and other organic con-stituents. It is secreted into minute bile canaliculi that originate between the hepatic cells. 2 Next, the bile flows in the canaliculi toward the interlobular septa, where the canaliculi empty into terminal bile ducts and then into progressively larger ducts, finally reaching the hepatic duct and common bile duct. 