<prompt> Characteristic of mixed connective-tissue disease are all of the following except: March 2005HypogammaglobulinemiaMembranous glomerulonephritisPolyahritisCNS involvement  <response>: Ans. A: Hypogammaglobulinemia Manifestations of mixed connective-tissue disease MCTD can be variable. Most patients experience Raynaud phenomenon, ahralgiaahritis, swollen hands, sclerodactyly or acrosclerosis, and mild myositis. The following may be revealed by history or physical examination: Raynaud phenomenon Ahralgia ahritis Esophageal hypomotility Pulmonary dysfunction Swollen hands Myositis Rash Leukopenia Sclerodactyly Pleuritis pericarditis Pulmonary hypeension Membranous glomerulonephritis Lab investigations shows features of inflammation with elevated ESR and hypergammaglobulinemia 