<prompt> Which of the following anaesthetic agent leads to increase in ICTThiopentoneKetaminePropofolSevoflurane  <response>: Ref: Katzung, 11th ed. pg. 437; KDT, 6th ed. pg. 376 Ketamine is the only intravenous anesthetic that possesses analgesic properties and produces cardiovascular stimulation. It causes dissociative anesthesia which is characterized by profound analgesia, immobility, amnesia and feeling of dissociation from ones own body and the surrounding. It has bronchodilator effect therefore considered as Induction agent of choice in asthma patient. In addition, it also causes: Hallucination Delusion and illusion Profound analgesia Ketamine increases all pressures like: BP hypertension, Heart rate, Cardiac output Intracranial tension it increases cerebral blood flow Intraocular pressure IOP It is contraindicated in intracerebral masshaemorrhage, MI, schizophrenia, EpilepsyMOA of Ketamine: It acts by blocking NMDA receptor of glutamate.Side effect of other given options: Propofol: Apnea, Decreases BP and HR Thiopentone: Laryngospasm, Shivering Delirium Etomidate: Adrenocortical suppression 