<prompt> Pagets disease is associated with ___:Decrease in bone mineralizationIncreased bone resorptionIncrease in bone turnoverIncreased degradation of collagen  <response>: Ans. C. Increase in bone turnoverPagets disease is characterized by increased bone turnover with enlargement and thickening of the bone, but the internal architecture of new bone is abnormal and so the bone is unusually brittle.Pagets disease is also called osteitis deformans.It manifests in 4th and 5th decade Males.The pathologic process in Pagets disease is initiated by overactive osteoclastic bone resorption followed by a compensatory increase in osteoblastic new bone formation.The presence of inclusion bodies resembling paramyxovirus in the pagetic osteoclasts suggests that the viral infection may contribute to the clinical features of Pagets disease.This results in a structurally disorganized mosaic of woven and lamellar bone.The following radiological image of Pagets disease shows widened diploic space and there are ill-defined sclerotic and lucent areas throughout. The cortex is thickened and irregular. 