<prompt> In pregnancy with increased MSAFP which of the following should be done:Repeat measurement of MSAFP at later dateUSGAmniocentesisTermination of pregnancy  <response>: MSAFP is a screening test. If it is raised, it should be followed by a diagnostic test, i.e. either USG or amniocentesis as discussed earlier, these days for diagnosis of NTD, USG has replaced amniocentesis, hence answer is USG. 