<prompt> Which of the following antiglaucoma medications can cause drowsinessLatanoprostTimololBrimonidineDorzolamide  <response>: Ans. is c i.e., Brimonidine Impoant systemic side effects of topical agents n-blockers : Bronchospasm, bradycardia, .cardiac output, hypotension, depression, impotence, altered lipid profile hypercholesterolemia. Sympathomimetics Non selective Dipivefrine, epinephrine :- Hypeension, arrhythmias Selective a-2 Brimonidine:- Drowsiness, fatigue, BP changes Selective a-1 a2 Apraclonidine :- Drowsiness, Headache, fatigue Chlinomimetics Pilocarpine :- Sweating, salivation, urinary frequency, diarrhea, bronchospasm. Carbonic anhydrase inhibitors Dorzolamide, brinzolamide :- Bitter taste, headache, asthenia, renal calculi. Prostaglandin analogues Latanoprost :- Headache, symptoms of UI. 