<prompt> Which of the following least likely to cause increase in bradykinin production?PerindoprilBenzprindoprilIrbesaanAll of the above  <response>: Ans c i.e. Irbesaan AT-II antagonists e.g. lrbesaan do not inhibit ACE rather they block AT-II receptor. o Therefore, they do not interfere with degradation of bradykinin and substance P bradykinin and substance P are degraded by ACE. o For the same reason AT-II antagonists do not cause cough angiodema caused by ACE inhibitors 