<prompt> Treatment of choice for chloroquine resistant malaria is :MefloquineSulfadoxine PyrimethaminePrimaquine ChloroquineChloroquine Pyrimethamine  <response>: Ans. is b. Sulfadoxine Pyrimethamine Under the recent National anti-Malaria Programme. the drug policy for malaria treatment is as follows-Any fever in endemic areas during transmission season without any other obvious cause may be considered as malaria and investigatedtreated accordingly.Drug resistance foci are prevalent in the country but chloroquine is still the safe, effective and cheap antimalarial drug and is simple to be administered.The best approach in malaria treatment is diagnosis and treatment on the same day.bPlasmodium falciparum predominant and drug resistance areasPresumptive treatment of all suspectedclinical malaria cases :Day 1 Tab. Chloroquine - 10 mgkg body weight 600 mg adult doseTab. Primaquine - 0.75 mgkg body weight 45 mg adult doseDay 2 Tab. Chloroquine - 10 mgkg body weight 600 mg adult doseDay 3 Tab. Chloroquine - 5 mgkg body weight 300 mg adult doseRadical treatment after microscopic confirmation of species :P vivax - Tab. Primaquine 0.25 mgkg body wt. 15 mg adult does daily for 5 days.P. falciparum - No further treatment required.In chloroquine resistant p. falciparum casesareaSingle dose of 25 mg kg bw tab. Sulfalene Sulfadoxine and 1.25 gg kg body wt. Pyrimethamine combination 3 tabs, adult does thereafter tab. Primaquine 0.75 mgkg body wt. These drugs should be given cautiously and not on the same day as both are known to precipitate haemolytic crisis in sensitive cases with G6PD deficiency.In low risk areasPresumptive treatmentDay 1 - Tab. Chloroquine 10mg kg body weight 600 mg adult doesRadical Treatment after confirmation of speciesP. Vivax - Tab. Chloroquine 10 mg kg body wt. single dose and tab. Primaquine 0.25 mgkg body wt. daily for 5 days.R falciparum - Tab. Chloroquine 10 mg kg body wt. plus tab. Primaquine 0.75 mg kg body wt. single dose.Severe and Complicated malaria - cases are to be hospitalized for treatment.Choice of antimalarial is quinine injection preferably, 10 mg kg body wt. IV drip in5 dextrose saline to be run over 4 hours, 8 hourly. Switch over to oral dose as early as possible and total duration of treatment should be 7 days including both parenteral and oral doses.Injectable form of Artemisinin derivative may be used for severe and complicated malaria only. The recommended injectable dosages are as follows :Artemisinin - 10mg.kg body wt. once a day for 5 days with a double divided does on first day.Artesunate - 1 mgkg body wt. IM or IV two doses at an internal of 4-6 hours on the first day followed by once a day for 5 daysArtemether - 1.6 mgkg body wt. IM, two doses at an interval of 4-6 hours on the first day followed by once daily for 5 days.Artether - 150 mg daily IM for 3 days for adults onlyTab. Mefloquine is to be used only in Pf. cases having proven resistance to chloroquine.Primaquine is not to be given to pregnant women, infants and glucose 6 phosphatase deficient persons. 