<prompt> Aspirin is contraindicated in?FeverPeptic ulcerUnstable anginaMyalgia  <response>: Ans. is b i.e., Peptic ulcer Contraindications of Aspirin Peptic ulcer Prostaglandin has cytoprotective function for gastric mucosa by inhibiting acid secretion and promoting secretion of mucus. Aspirin inhibits synthesis of cytoprotective PG -3 bleeding perforation may occur. Children with chicken pox influenza Aspirin can cause Reyes syndrome hepatic encephalopathy. Acknowledging this aspirin should not be given to children 12 years, e.g. in JRA. Bleeding tendencies By its antiplatelet action, aspirin can exacerbate bleeding. Chronic liver disease Long-term therapy with high dose aspirin can cause insidious onset hepatic injury. 