<prompt> Non immune hemolytic anemia occurs in -SLEP. vivax infectionCLLCML  <response>: Ans. is b i.e., P. vivax infection Non-Immune hemolytic anemia In non-immune hemolytic anemia, hemolysis occurs without formation of antibodies against RBCs. o Combs test is negative, therefore it is also known as Coombs negative hemolytic anemia. o Causes are : - ID Drugs -- Ribavarin Toxins -- Snake venum, plant poisons such as aesculin. Mechanical trauma to RBCs -- prosthetic hea valve, thrombosis in microcirculation. Microangiopathic hemolytic anemia : ? Thrombotic thromhocytopenia purpura TTP, Hemolytic uremic syndrome HUS, D1C, HELLP syndrome. Infections : - Babesiosis, Malaria, Clostridiun perfringens sepsis. Hereditory spherocytosis, Thalassemia, SCA, Paroxysmal nocturnal hemoglobinuria, Liver disease. 