<prompt> A 7-year-old male patient presented with ceain lesions on the face and the lumbosacral region. Patient also gave a history of frequent episodes of seizures for which NCCT head was done. Which of the following chromosomes is involved in the above disease: -22q17q9p9q  <response>: THIS IS A CLASSICAL CASE OF TUBEROUS SCLEROSIS. Image A is of Adenoma sebaceum over face Image B is of Shagreen patch over lumbosacral region. Image C is cranial CT showing Subependymal nodules in lateral ventricles. All these findings are characteristic features of TUBEROUS SCLEROSIS inherited in AUTOSOMAL DOMINANT manner. The gene involved is TSC1hamain on chromosome 9p34. 22q and 17q are involved in neurofibromatosis 2 and 1 respectively. Other impoant features of tuberous sclerosis: Ash leaf macule Koenens tumour periungual fibroma Renal angiomyolipoma Ash leaf macules Retinal hamaoma Pulmonary lymphangiomyomatosis. Vogts triad: epilepsy low iq adenoma sebaceum. Infantile spasm 