<prompt> What is TRUE about clomiphene?Enclomiphene is anti-estrogenicPregnancy rate is comparable to placeboSignificantly increases sperm counts in oligospermic men1 - 2 increase in rate of twin pregnancy  <response>: Clomiphene citrate Trans enclomiphene 62: anti-estrogenic Cis zuclomiphene citrate 38 : mildly estrogenic This Primarily acts at the receptor in Hypothalamus rather than the Ovarian and Pituitary axis. Blockade increases the stimulus to the pituitary to produce more FSH. -Antagonises the beneficial actions of estrogens on the endometrium and hence a supplementation of estrogen is required in patients on higher doses of clomiphene for ovulation induction -6-12 increase in rate of twins Oligospermia relief is not the best benefit of Clomiphene...statistically, because roughly 10-15 only are benefited with this in oligospermia reversal. 