<prompt> Wernickes encephalopathy can be prevented by:IV salineLarge amounts of glucoseThiamine supplementImipramine  <response>: C. i.e. Thiamine supplement The patient is having Wernickes disease chronic alcoholism, ataxia, opthalmoplegia Wernickes DiseaseIt is a common preventable disorder occurring Wt deficiency of thiamineQ, most commonly associated with poor nutritional habits of people with chronic alcohol abuseQ. But other causes of malnutrition eg starvation, hyperemesis gravidarum, prolonged intravenous hyperalimentation, gastric placation surgery, gastric carcinoma, hemodialysis, cancer AIDS can cause thiamine deficiency.Thiamine is a cofactor of transketolase, pyruvate dehydrogenase a-keto glutarate dehydrogenase. So its deficiency produces a diffuse decrease in cerebral glucose utilization I t mitochondrial damage and glutamate accumulation resulting in excitotoxic damage. Pathologically periventricular i.e. around 3rd -4th ventricle aqueduct lesions with petechial hemorrhages in acute cases and atrophy of mamillary body in chronic cases is seen. Amnesia is related to lesions in dorsal medial nuclei of thalamus, or medial temporal lobe hippocampus coex. 