<prompt> Bupivacaine toxicity causes -Renal toxicityPulmonary toxicityCardiotoxicityNone  <response>: Ans. is c i.e., CardiotoxicityBupivacaineo Bupivacaine is 2nd most commonly used local anaesthetic after lidocaine.o Bupivacaine has the highest local tissue irritancy amongst local anaesthetics,o It is the most cardiotoxic local anaesthetic.o Levobupivacaine The S- enantiomer of bupivacaine is less cardiotoxic and less prone to cause seizure,o Concentrations used for bupivacaine are : - Nerve block : 0.5, Epidural: 0.25 - 0.5 , and spinal: 0.5.o Maximum safe dose is 2 mgkg without adrenaline and 3mgkg with epinephrine. 