<prompt> In Hereditary spherocytosis an inherited abnormality is seen in which of the following red blood cell component-A-globin chaina-globin chainPhosphatidylinositol glycan ASpectrin  <response>: HS is caused pathogenic mutations that affect ankyrin , band 3, spectrin , or band 4.2. Which causes insufficiency of membrane skeletal components. Ref :Robbins pathologic basis of disease ; south east asia edition ;pg:633 