<prompt> A 45year-O1d male has rhinitis, bronchial asthma, eosinophilia, and systemic vasculitis. What is the probable diagnosis?Goodpasture syndromeCryptogenic fibrosing alveolitisChurg-Strauss syndromeSarcoidosis  <response>: Churg-Strauss syndrome,also referred to as allergic angiitis and granulomatosis,is characterised by asthma,peripheral and tissue eosinophilia,extravascular granuloma formation,and vasculitis of multiple organ systems.The pulmonary findings in Churg-Strauss syndrome are severe asthmatic attacks and the presence of pulmonary infiltrates.The characteristic laboratory finding in viually all patients with Churg-strayss syndrome is a striking eosinophilia,which reaches levels1000 cellsmicroL in 80 of patients.Approximately,48 of patients with Churg-Strauss syndrome have circulating ANCA that is usually antimyeloperoxidase. Ref:Harrisons medicine-18th edition,page no:2793. 