<prompt> The therapeutic efficacy of antihypertensive drugs is blunted by NSAIDs because they:Cause sodium excretionIncrease the clearance of antihypertensive drugsDecrease the absorption of antihypertensive drugsDecrease the synthesis of vascular prostacyclin  <response>: PGE2 and PGI2 cause renal vasodilation, natriuresis and increased water clearance due to inhibition of the action of ADH.Loop diuretics act partly by increasing the stimulation of COX; therefore NSAIDs attenuate the diuretic action of these drugs. 