<prompt> Tubocurare affects which muscle first?Head and neckLimbsRespiratory musclesAbdominal muscles  <response>: Sequence of blockade : face - jaw- pharynx - larynx - respiratory including diaphragm - trunk muscle - limb muscle. Face muscles are involved earliest. 1in non-depolarising blocker d-Tc, earliest clinical sign is Ptosis and diploia 2In succinylcholine depolarising blocker ,First clinical sign is Fasciculation of eye lids. 