<prompt> The commonest mode of inheritance of Von Willebrands disease :CodominantAutosomal recessiveAutosomal dominantX-linked recessive  <response>: Answer is C Autosomal dominant There are 3 major forms of Von WilleBrands disease and with one exception i.e. type III all forms are inherited as autosomal dominant trait- Harrison 16th676 Von WilleBrands disease is the most common hereditary coagulation disorder characterized by a quantitative or qualitative defect in Von Willebrands factor Factor VIII circulates in blood as a complex with vWF Propey VWF Factor VIII Gene Located on chromosome XII Located on -2 X chromosome Inheritance Autosomal dominant Q Sex linked Synthesis Endothelial cells. megakaryocytes platelets not in liver cells 2 In liver cells - Function Facilitate the adhesion of platelets to subendothelial collagen V. W. disease Activation of factor X in coagulation cascade. Hemophillia Disease 