<prompt> Genetic abnormality in case of late adenoma to carcinoma in Ca colon:APCK-rasDCCp53  <response>: The most frequently mutated tumor suppressor gene in human neoplasia is p53 TP53, located on chromosomes 17p. Mutations in p53 are present in 75 of colorectal cancers and occurs, rather late in the adenoma-carcinoma sequence. FEARON - VOGELSTEIN ADENOMA CARCINOMA MULTISTEP MODEL 