<prompt> Which of the following statement is true regarding Atazanavir:-Effective against only HIV-1Resistance is due to mutation in codon 50 isoleucine to valine substitutionDecrease cholesterol and triglyceride levelsCombination with ritonavir do not have any advantage  <response>: Atazanavir is effective against both against HIV 1 and HIV 2 but NNI are effective only against HIV 1. They do not decrease cholesterol and triglyceride levels. Combination with ritonavir have an advantage due to the phenomenon of Ritonavir boosting. The resistance is due to mutation in codon 50 isoleucine to valine substitution. 