<prompt> A 48 year old women was admitted with a history of weakness for two months. On examination, cervical lymph nodes were found enlarged and spleen was palpable 2 cm below the costal margin. Her hemoglobin was 10.5 gdl, platelet count 2.7 x lOL and total leukocyte count 40 x WfL, which included 80 mature lymphoid cells with coarse clumped chromatin. Bone marrow revealed nodular lymphoid infiltrate. The peripheral blood lymphoid cells were positive for CD 19, CD 5, CD20 and CD23 and were negative for CD 79 B and FMC - 7. The histopathological examination ofthe lymph node in this patient will most likely exhibit effacement of lymph node architecture by -A pseudofollicular pattern with proliferation centersA monomorphic lymphoid proliferation with a nodular patternA predominantly follicular patternA difiuse proliferation of medium to large lymphoid cells with high mitotic rate.  <response>: Lymphoid tumors: Cytologic classification: - undifferentiated stem cells; - histiocytes, reticular cells; - lymphoblastic, lymphocytic, poorly differentiated; - prolymphocytic and lymphocytic, lymphocytic, well differentiated; - Hodgkin-like; Anatomical classification: - multicentric; - thymic; - digestive; - cutaneous; - solitary. Lymphocytic leukemia. Plasmacytic tumors, multiple myeloma, plasmacytoma. Thymoma: - predominantly epithelial; - predominantly lymphocytic. At present, RAPPAPOs classification, WHO and other classifications are considered obsolete, being replaced by the classification proposed by KIEL and the National Cancer Institute classification . The classification of lymphoproliferative diseases of the International Lymphoma Study Group, corrected by the Revised European-American Lymphoma REAL system is under way. This classification compares KIELs classification to that proposed by the international group Classification according to anatomoclinical criteria acute leukemia: lymphoblastic, myeloid and undifferentiated; chronic leukemia: lymphoid, myeloid, and tricholeukocytic leukemia; malignant lymphomas: Hodgkins disease, non-Hodgkin malignant lymphomas, reticulosarcomas and lymphosarcomas. Classification according to pathophysiological criteria - Myeloproliferative syndromes: - chronic: primitive polyglobulia or Vaquezs disease or true polycytemia; chronic myeloid leukemia; essential thrombocytemia; essential myelofibrosis or myeloid splenomegaly and mastocytoma; - acute: acute myeloid leukemia; acute myelomonocytic leukemia; eosinophilic leukemia; basophilic leukemia; erythroleukemia; acute mega-karyocytic leukemia; undifferentiated leukemia; oligoblastia and aleukemia. - Lymphoproliferative syndromes: Waldenstroms macroglobulinemia; multiple myeloma or Kahlers disease, thymoma, fungoid mycosis; lymphoid leukemia and malignant lymphomas TUMORS OF LYMPHOID SYSTEM B-Cell Lymphoid Neoplasms 1.1 Precursor B-cell neoplasms 1.1.1 B-cell lymphoblastic leukemialymphoma 1.2 Mature B-cell neoplasms 1.2.1 B-cell chronic lymphocytic leukemialymphoma 1.2.2 B-cell lymphocytic lymphoma intermediate type LLI 1.2.3 Lymphoplasmacytic lymphoma LPL 1.2.4 Follicular lymphomas 1.2.4.1 Mantle cell lymphoma MCL 1.2.4.2 Follicular center cell lymphoma I 1.2.4.3 Follicular center cell lymphoma II 1.2.4.4 Follicular center cell lymphoma III 1.2.4.5 Nodal marginal zone lymphoma 1.2.4.6 Splenic marginal zone lymphoma 1.2.5 Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue MALT lymphoma 1.2.6 Hairy cell leukemia 1.2.7 Plasmacytic tumors 1.2.7.1 Indolent plasmacytoma 1.2.7.2 Anaplastic plasmacytoma 1.2.7.3 Plasma cell myeloma 1.2.8 Large B-cell lymphomas 1.2.8.1 T-cell-rich B-cell lymphoma 1.2.8.2 Large cell immunoblastic lymphoma 1.2.8.3 Diffuse large B-cell noncleaved, cleaved lymphoma 1.2.8.4 Thymic B-cell lymphoma mediastinal B 1.2.8.5 Intravascular large B-cell lymphoma 1.2.9 Burkitt-type lymphoma 1.2.9.1 High-grade B-cell lymphoma, Burkitt-like T-Cell and NK-Cell Lymphoid Neoplasms 2.1 Precursor T-cell neoplasms 2.1.1 T-cell lymphoblastic leukemialymphoma 2.2 Mature T-cell and NK-cell neoplasms 2.2.1 Large granular lymphoproliferative disorders LGL 2.2.1.1 T-cell chronic lymphocytic leukemia 2.2.1.2 T-cell LGL lymphomaleukemia 2.2.1.3 NK-cell chronic lymphocytic leukemia 2.2.2. Cutaneous T-cell neoplasms 2.2.2.1 Cutaneous epitheliotropic lymphoma CEL 2.2.2.1.1 CEL, mycosis fungoides type 2.2.2.1.2 CEL, pagetoid reticulosis Woringer-Kolopp type 2.2.2.2 Cutaneous nonepitheliotropic lymphoma 2.2.3 Extranodalperipheral T-cell lymphoma PTCL 2.2.3.1 PTCL, mixed lymphoid type 2.2.3.2 PTCL, mixed inflammatory type 2.2.4 Adult T-cell-like lymphomaleukemia 2.2.5 Angioimmunoblastic lymphoma AILD 2.2.6 Angiotropic lymphoma 2.2.6.1 Angiocentric lymphoma 2.2.6.2 Angioinvasive lymphoma 2.2.7 Intestinal T-cell lymphoma 2.2.8 Anaplastic large cell lymphoma ALCL Ref Davidson 23rd edition pg 1317 