<prompt> Which of the ATT drugs is not hepatotoxic?PyrazinamideINHRifampicinStreptomycin  <response>: Ans. is d i.e., Streptomycin Important educational points First line antitubercular drugs causing hyperuricemia - Ethambutol, pyrazinamide. Drugs causing peripheral neuropathy - streptomycin, INH, Ethambutol, ethionamide. Drugs causing hepatitis - INH, rifampicin, pyrazinamide, ethionamide. Optic neuritis - INH, ethambutol, ethionamide. First line antitubercular drugs which are not hepatotoxic does not require dose adjustment in liver diseases - streptomycin, ethambutol. Drugs not requries dose adjustment in renal failure - rifampicin, rifabutin rifapentine. Hypothyroidism can be caused by - PAS, ethionamide. Ethambutol and streptomycin do not cross BBB. Active against extracellular mycobacteria: Rifampicin Tuberculocidal, INH tuberculocidal, streptomycin tuberculocidal Active against intercellular mycobacteria: Rifampicin Tuberculocidal, INH tuberculocidal, Pyrazinamide tuberculocidal 