<prompt> All of the following statements about Lebers Hereditary Optic Neuropathy LHON are true except:Mutation in mitochondrial DNA,MT-ND4 geneFluorescein angiography shows leakage from the microangiopathic vesselsUsually affects males between the ages of 15 -35 yearsChalky white optic disc  <response>: Leber hereditary optic neuropathy LHON Rare ganglion cell degeneration. Papillomacular bundle is paicularly affected. Caused by maternally inherited mitochondrial DNA point mutations, MT-ND4 gene. Affects males between the ages of 15 -35 years, although in atypical cases the condition may affect females and present at any age between 10 -60 years. Diagnosis- Bilateral optic neuropathy, irrespective of age. Signs are:- Preceded by swelling of the optic nerve head Hyperemic disc - Chalky white optic disc Dilated capillaries on the disc surface circumpapillary telangiectasia these may extend onto adjacent retina telangiectatic microangiopathy. Swelling of the peripapillary nerve fibre layer Pseudo-oedema FA shows no leakage from the disc or microangiopathic vessels. 