<prompt> A mother with 10 weeks pregnancy and who had previously delivered a baby with open neural tube defect which statement is true :Sodium valproate causes open neural tube defectRisk of recurrence is 10Amniocentesis should be doneGive multivitamin  <response>: Ans. is a i.e Sodium valproate causes open neural tube defect Sodium valproate used during pregnancy. has produced neural tube defects in the offspring; therefore should be avoided. Therefore option a is correct The risk of recurrence of anencephaly is 5 after one affected child and 13 after two affected children.deg Therefore option b is incorrect. Diagnostic protocol in case of patients who have had a child with neural tube defect : In such patients At 16 weeks of gestation - Level II ultrasound Maternal serum alpha feto protein MSAFP. Based on the results of these two investigations : the need for amniocentesis is decided. 