<prompt> A 50-year-old male with a positive family history of prostate cancer has come to you for a screening test. The most sensitive screening test to pickup prostate cancer isDREPSADRE PSAEndorectal Coil MRI with T1W and T2W images  <response>: At the present time the data suggest that if screening is done, the combination of DRE Serum PSA is best. The diagnosis of Ca Prostate is established by TRUS-guided transrectal biopsy. Ref : Smiths Urology 17e p363 