<prompt> Which of the following statements about fluconazole is most accurate?It is highly effective in the treatment of aspergillosisIt does not penetrate the blood-brain barrierIts oral bioavailability is less than that of ketoconazoleIt inhibits demethylation of lanosterol  <response>: Fluconazole Azoles act by inhibiting the enzyme lanosterol-14-a-demethylase resulting in reduced ergosterol synthesis. It has very good CNS penetration and oral bioavailability. It is not very effective against aspergillosis voriconazole is the drug of choice. 