<prompt> The following is not a feature of malignant transformation by culturedcIncreased cell densityIncreased requirement for growth factorsAlterations of cytoskeleton structureLoss of anchorage  <response>: Ref biology of the cell p357-364 Both normal cells and cancer cells can be cultured in-vitro , however they behave quite differently normal cell: show replicative senescence .is cells pass through limited number of cell division before they decline in vigor and die it may caused by inability to synthesise telomerase 