<prompt> Mechanism of action of lovastatin ?HMG CoA reductase inhibitorDecarboxylase inhibitorActivate lipoprotein lipaseInhibits lipolysis  <response>: Ans. is a1 i.e., HMG CoA reductase inhibitor o HMG CoA reductase inhibitors statinsstatins are the most efficacious and best tolerated hypolipidemia drugs.They competitive inhibit conversion of 3-Hydroxyl-3-methylglutaryl coenzyme A HMG-CoA to mevalonate rate-limiting step in CH synthesis by HMG CoA reductase.Therapeutic doses reduce CH syntheses by 20-50.This results in compensatory increase in LDL-receptor expression on liver also- increased.Important members of this group HMG-CoA reductase inhibitory are -o Lovastatino Simvastatino Atorvastatino Rosurvastatino PonastatinAlways remember -o Most potent statin is rosuvastatin Atorvastatin Fluvastatin Lovastatino These drugs have no effect on lipoprotein ao Statin are most powerful LDL lowering agents. These drugs also lower T.G., VLDL and HDL slightly.o Statins also posses antioxidant, anti-inflamatory and antiproliferative properties in addition to lipid - lowering effects. These are known pleio tropic effects of statin,o Parvastatin also causes decrease in plama fibrinogen levels.o Food es the absorption of all drugs except parvastatin. All dmgs can be absorbed orally.o Lovastatin and simvastatin undergo extensive 1st pass metabolism and are administered as prodrugs,o Major adverse effects are myopathy hepatoxicity.o Statins are 1st line drugs for Type Ha, lib secondary hyperlipoproteinemia. 