<prompt> Which of the following is the first line drug for follicle induction in infeility in PCOSClomiphene citrateGnRH agonistCombined oral PillsLetrozole  <response>: Letrozole is the Drug of choice- Induction of ovulation in a case of PCOS; Mode of action- Aromatase Inhibitor Decrease Estrogen production--Inhibit Negative feedback on FSH -- increases FSH -- increase stimulation of follicles Letrozole preferred over Clomiphene citrate because decreases chances of multifetal pregnancy increased live bih rate OHSS : Rare with it Given for 5 days D5-D9 Sta with 2.5mg Max dose 7.5mg 