<prompt> Which of the following agent is NOT used in management of bronchial asthma: March 2012, March 2013Phospho-di-esterase inhibitorsSteroidsBeta agonistsCholinergic drugs  <response>: Ans: D i.e. Cholinergic drugs Drugs and uses Methylxanthines theophylline, aminophylline, doxophylline etc. acts by 3 distinct cellular actions. i Release of calcium from sarcoplasmic reticulum, ii inhibition of phosphodiesterase and iii blockade of adenosine receptors. Coicosteroids benefit in asthma by reducing bronchial hyper-reactivity, mucosal edema and by suppressing inflammatory response to antigen: antibody reaction or other trigger stimuli. Beta agonistssympathomimetics causes bronchodilatation through beta2 receptor stimulation --n increased cAMP formation in bronchial muscle cell relaxation. Cholinergic drugs will precipitate asthma, by causing bronchoconstriction instead anticholinergic drugsatropine is used, which causes bronchodilatation by blocking cholinergic constrictor tone. 