<prompt> CA-125 is specific marker of:ChoriocarcinomaTeratomaEpithelial cell carcinoma of ovarySeminoma  <response>: Ans. is c, i.e. Epithelial cell carcinoma of ovaryRef: Shaw 15thed, p387; Williams Gynae 1sted, p722 CA-125 is a glycoprotein secreted by malignant epithelial tumors of ovary. Therefore it is a marker of epithelial cell carcinoma of ovary. CA-125 level correlates with volume of tumor and is elevated in 50 of Stage I tumor and 90 of tumors with Stage II or higher. CA-125 level is also useful for follow up after treatment. Level 35unitsml suggests residual tumor.Remember: Two best screening test for ovarian ca are measurement of CA-125 levels and transvaginal USG. CA-125 is raised in: - Ref: Harrison 16thed, p554Benign conditionMalignant condition Pregnancy PID Endometrioses Uterine fibroid About 1 of normal females Endometrial Ca Pancreas Ca Colon Ca Cervix Ca Fallopian tubes Ca Breast Ca Ovarian epithelial Ca MC cause Lung CaMnemonic: Endogenous Pneumocystis Carinii Causes TB Of Lungs In a postmenopausal women with an asymptomatic pelvic mass and CA-125 65Uml is very sensitive for diagnosis of ovarian epithelial tumor. Although CA 125 is raised in many cancers it is specific for epithelial ovarian cancer. 