<prompt> Mediator of acute inflammation not derived from the cell is D. REPEAT Feb 2014HistamineKininsLeukotrienesCytokines  <response>: Chemical Mediators of InflammationAka permeability factors or endogenous mediators of increased vascular permeability.They are broadly classified into 2 groups:i. Mediators released by cells.ii. Mediators originating from plasma.Chemical Mediators of Acute InflammationA. Cell-Derived Mediators1. Vasoactive aminesHistamine5-hydroxytryptamineNeuropeptides2. Arachidonic acid metabolites Eicosanoidsi. Metabolites via cyclo-oxygenase pathwayProstaglandinsThromboxane A2ProstacyclinResolvinsii. Metabolites via lipo-oxygenase pathway5-HETELeukotrienesLipoxins3. Lysosomal components from PM Ns, macrophages4. Platelet-activating factor PAF5. CytokinesIL-1TNF-αTNF-βIFN-γChemokines6. Free radicalsOxygen metabolitesNitric oxideB. Plasma-Derived Mediators Plasma Proteases Products of:1. The Kinin system.2. The Clotting system.3. The Fibrinolytic system.4. The Complement system. 