<prompt> Huhle cells seen in ?Papillary carcinomaHashimoto ThyroiditisGranulomatous thyroiditisThyroglossal cyst  <response>: Ans. is b i.e., Hashimoto ThyroiditisPathological features of Hashimotos thyroiditis 1. Cross featuresDiffuse symmetrically enlarged thyroidAlthough the gland is symmetrically enlarged, the accentuation of lobulations may make the gland appear lobular on gross examination.Capsule is intactCut surface is pale, yellow firm and lobulated.2. Microscopic featuresAtrophy of thyroid follicles atrophic folliclesExtensive lymphoplasmocytic infiltrate with abundant small lymphocytes and plasma cells with destruction of follicles.Oncocytic metaplasia Huhle cell metaplasia - The surviving follicular epithelial cells are commonly transformed into large cells with abundant pink cytoplasm and are known as Huhle cells.Oncocytic metaplasia Huhle cell metaplasia is also known oxyphilic change in epithelial cells and is considered the hallmark of Hashimotos thyroiditis.Varying degree of fibrosis and foci of squamous metaplasia within atrophic follicles.Interstitial connective tissue is increased and may be abundant. 