<prompt> All the following factors predispose to Aoic dissection , exceptSystemic hypeensionTakayasus aeritis1 at trimester of pregnancyMarfans syndrome  <response>: Ref Harrison 19 th ed pg 1541 Aoic dissection is the major cause of morbidity and moality in patients with Marfans syndrome or Loeys- Dietz syndrome, and similarly may affect patients with Ehlers-Danlos syndrome. The incidence also is increased in patients with inflamma- tory aoitis i.e., Takayasus aeritis, giant cell aeritis, congenital aoic valve anomalies e.g., bicuspid valve, coarctation of the aoa, and a history of aoic trauma. In addition, the risk of dissection is increased in otherwise normal women during the third trimester of pregnancy. Aoic dissection also may occur as a consequence of weight lifting, cocaine use, or deceleration injury. 