<prompt> First antibody to appear in hepatitis -IgM anti-HbeIgG-anti-HbeIgM-anti-HBcIgM anti-HBs  <response>: Anti-HBV appears in serum a week or two after the appearance of HBsAg. It is therfore the earliest antibody marker to be seen in blood? long before anti-HBe or anti-HBs. REF:ANANTHANARAYAN AND PANIKERS TEXTBOOK OF MICROBIOLOGY 9TH EDITION PAGE NO-546 