<prompt> All of the following are true of Reye;s syndrome, exceptIt frequently complicates viral infectionsProthrombin time is prolongedDisease may be precipitated by salicylatesDeep jaundice is present  <response>: Reye;s Syndrome Fatty Liver with EncephalopathyAcute illness, encountered exclusively in children 15 yearsOnset usually follows an upper respiratory tract infection, especially influenza or chickenpoxCharacterized clinically by:VomitingSigns of progressive CNS damageSigns of hepatic injuryHypoglycemiaCause is unknown, although viral agents and salicylates have been implicated however, this illness can occur in absence of exposure to salicylatesThe liver is enlarged, but jaundice is characteristically absent or minimalMoality rate in Reye;s syndrome is approx. 50HistopathologyLaboratory findingsMorphologically, extensive vacuolization of the liver and renal tubulesMitochondrial dysfunction with decreased activity of hepatic mitochondrial enzymes with structural alterations of mitochondria in the liver, brain, and muscle In fatal cases, the liver is enlarged and yellow with striking diffuse fatty micro vacuolization of cells.Major extra-hepatic changes are fatty changes of the renal tubular cells, cerebral oedema and neuronal degeneration of the brainRaised aminotransferases PT3Hypoglycemia Metabolic acidosisElevated serum ammonia levelTreatmentInfusion of 20 glucose and fresh frozen plasma IV. mannitol to reduce cerebral oedemaRefer: Harrisons Principles of Internal Medicine, 18thedition, pg no: 147, 1463 1465 