<prompt> MIC hazard of chorionic villous biopsy is:Limb abnormalitySpina bifidaDowns syndromeAbortion  <response>: Ans. is d, i.e. AbortionRef. Williams Obs. 23e, p 300; Dutta Obs. 7e, p 107It must be quite surprising for some you that why I have not marked option a i.e. Limb abnormality as the answer.This is because Williams Obs. 23e, p 300 says--Early reports of an association between CVS and limb reduction defects, oromandibular defects and cavernous hemangiomas have been disproved.When CVS is performed after 9 weeks, Kuliev and Colleagues 1996 reported the incidence of limb-reduction defects to be 6 per 10,000 - the same as the background incidence.The frequency of oromandibular limb hypogenesis however was increased after CVS when the procedure was performed before 9 weeks.Therefore, It can be concluded--MC complication caused by CVS, if performed before 9 weeks is oromandibular and limb defects otherwise MC complication of is CVS is increased chances of fetal loss abortion. 