<prompt> Trastuzumab all are true EXCEPT -Shows better response in combination with paclitaxelUsed in metastatic breast cancerCauses upregulation of HER2neuDo not causes bone marrow toxicity  <response>: Ans. is c i.e., Causes upregulation of HER2neu o It has been suggested that trastuzumab induce some of its effects by down regulation of HER2neu not upregulation o Currently transtuzumab is approved for HER2neu overexpressing metastatic breast cancer in combination with paclitaxel as initial treatment or as monotherapy following chemotherapy. o Herceptin use is associated with infusion-related hypotension, flushing and bronchoconstriction, and skin rash but no bone marrow toxicity. 