<prompt> Thrombomodulin-thrombin complex produces its anticoagulant effect by-Inactivating factor V and VIIIInactivating protein CInactivating protein SInactivating factor VIII  <response>: Thrombomodulin Present on the endothelial cells and binds to thrombin and activates protein C, which inhibits clotting by proteolysis of factor Va and VIIIa. Ref: RAM DAS NAYAK 2nd Ed. Pg 89 