<prompt> Drug effective for most trematodes and many cestodes-PraziquentalPirenzipineNiclosamidsPyrantel palmoate  <response>: Ans. is a i.e., Praziquantal Praziquental o Praziquantal is the DOC for treatment of all trematodes and cestodes except for fasciola hepatica DOC bithionol and hydatid disease DOC albendazole, Neurocysticercosis DOC is albendazole. o It acts by causing leakage of intracellular calcium from the membrane --9 contracture paralysis. o At relatively higher concentrations, it causes vacuolization of the tegument and release of the contents of tapeworms and flukes followed by their destruction by the host -3 this action appear to be more impoant in case of schistosomes and flukes. o Despite systemic absorption praziquantel exhibits no systemic toxicity. 