<prompt> Risk of breast cancer is highest inLobular carcinoma in situProliferative disease without atypiaProliferative disease with atypiaAtypical ductal hyperplasia  <response>: Atypical ductal or lobular hyperplasia are proliferative disease with atypia. Lobular carcinoma in situ carries the highest riskHISTOLOGIC DIAGNOSIS ESTIMATESRRNonproliferative disease1.0Proliferative disease without atypia1.3-1.9Proliferative disease with atypia3.7-4.2Proliferative disease with atypia and strong family history4-9LCIS 7Ref: Sabiston 20e, page: 832 