<prompt> The most common translocation seen in patients with Multiple Myeloma ist11;14t4;14t14;16t14;20  <response>: Answer is A t11;14 The most common translocation seen in patients with Multiple Myeloma is 01;14. The most common translocation seen in patients with Multiple Myeloma is t11;14q13;q32 involving the BCL1 locus on chromosome 11g13 and the immunoglobulin heavy IgH chain locus on chromosome 14q13 which leads to overexpression of Cyclin D1 - The Washington Manual of Surgical Pathology The two most common translocation seen in patients with Multiple Myeloma are t11;14and t4; 14. Both these translocations occur with almost similar frequencies, however the incidence of translocation 111; 14 appears to be marginally higher. Patients with t4; 14 fall within a poor prognosis subgroup, while those with 111; 14 have a standard risk - The Principles of Clinical Cytogenetics The two most common translocation seen in patients with Multiple Myeloma t11;14q13;q32 : Associated with standard prognosis t4;14 p16;q32 : Associated with aggressive behaviour and poor prognosis The most common translocation in multiple myeloma associated with a poor prognosis is translocation t4;14 