<prompt> Chromophobe variant of renal cell is associated with -VHL gene mutationsTrisomy of 7 and 17 7, 173 p deletions 3p-Monosomy of 1 and Y -1, -Y  <response>: These tumors are unique in having multiple losses of entire chromosomes, including chromosomes 1, 2, 6, 10, 13, 17, and 21. Thus, they show extreme hypodiploidy. Because of multiple losses, the critical hit has not been determined. Ref: Robbins basic pathology 9th edition page548 