<prompt> The most common site of GIST is -IleumEsophagusColonStomach  <response>: Gastrointestinal stromal tumors GISTs GISTs are the most common mesenchymal neoplasm of gastrointestinal tumor.GIST represents a distinct group of gastrointestinal tumors that originate from the interstitial cells of cajal which control gastrointestinal peristalsis.GISTs can occur anywhere in the gastroinstestinal tract; the most common site being the stomach followed by the small intestine.Stomach 50-70Small intestine 20-30Colon rectum 5-15Esophagus 5 