<prompt> Principal cause of death in renal transplant patientUraemiaMalignancyRejectionInfection  <response>: Ref cambells urology,8e p346-349 The graft rejection response is initiated mainly by host T cells that recognize the foreign HLA antigens of the graft, either directly on APCs in the graft or indirectly after uptake and presentation by host APCs. Types and mechanisms of rejection comprise the following: Hyperacute rejection: Pre-formed antidonor antibodies bind to graft endothelium immediately after transplanta- tion, leading to thrombosis, ischemic damage, and rapid graft failure. Acute cellular rejection: T cells destroy graft parenchyma and vessels by cytotoxicity and inflammatory reactions. Acute humoral rejection: Antibodies damage graft vasculature. Chronic rejection: Dominated by aeriosclerosis, this type is probably caused by T cell reaction and secretion of cytokines that induce proliferation of vascular smooth muscle cells, associated with parenchymal fibrosis. Principal cause of death is due to infection and inflammation 