<prompt> Sunder, a young male was diagnosed as sufering from acute myeloid leukemia. He was staed on induction chemotherapy with dosorubicin based regiments. Induction regimen was successful. Two months later, he presents to OPD with swelling of both the feet and breathlessness on climbing the stairs. He also complains the he had to wake up many times because of breathlessness. Which of the following is most likely responsible for this patients symptoms?Restrictive cardiomyopathyHyperophic cardiomyopathyDilated cardiomyopathyPericardial fibrosis  <response>: Ref: Katzung 11e p952 Anthracyclines daunorubicin, doxorubicin, eirubicin and idarubicin can cause severe cardiotoxicity manifesting as dialted cardiomyopathy and arrhythmias. The anthracycline chemotherapeutic agents doxorubicin, daunorubicin, epirubicin and idarubicin form free radicals in the myocardium. Their most severe side effect is a cumulative doserelated dilated cardiomyopathy. It presents with symtoms of left and right ventricular CHF. 