<prompt> All are seen in primary extraglandular Sjogrens syndrome except -Rheumatoid arthritisRaynauds diseaseLymphomaSplenomegaly  <response>: Ans. is a i.e., Rheumatoid arthritis o Primary Sjogren syndrome is not associated with other autoimmune disorders, e.g. Rheumatoid arthritis,o Sjogren syndrome occurs in elderly 50-60 yrs female.o Primary Sjogren syndrome Sicca syndrome has two types of clinical manifestationsSjogren SyndromeInvolvement of exocrine glandExtraglandularo Exocrine glands are the primary targeto Most common glands involved are -1. Lacrimal glands - dry eyes Keratoconjunctivitis sicca2. Salivary glands - dry mouth Xerostomiao Occurs in 13 rd patientso Raynauds phenomenono Vasculitiso ArthralgiaArthritiso Lymphadenopathyo Lymphomao Splenomegalyo Lung involvemento Kidney involvemento Peripheral neuropathyo Myositiso Liver involvemento In Sjogren syndrome, there is increased risk of development of marginal B-cell lymphoma.o Amongst the extraglandular manifestations, ArthralgiaArthritis is most common.Remembero The biopsy of the lip to examine minor salivary glands is essential for the diagnosis of Sjogren syndrome.o The characteristic decrease in tears and saliva is the result of lymphocytic infiltration and fibrosis of lacrimal and salivary gland.o Anti SS-A Ro and anti SS-B La antibodies are the serological markers of Sjogren syndrome. 