<prompt> Which of the following is aldosterone antagonist?EplerenoneDeoxicorticosteroneFenoldopamFrusemide  <response>: Ans. a Eplerenone Ref. KDT 5thpg. 534; Katzung 9thpg. Chapter 11Eplerenone is a new, selective mineralocorticoid receptor antagonist without clinically significant androgen receptorblocking or progesterone receptor stimulating activities, which translates into absence of gynecomastia and impotence inmen and of menstrual irregularity in women. It is approved in treatment of hypertension.Mineralocorticoid receptors are expressed in many tissues, including: Kidney, Colon, Heart, Central nervous system hippocampus, Brown adipose tissue and Sweat glands not in liver.Educational points: Lithium demeclocyline are ADH antagonists. 