<prompt> Which of the following medications is contraindicated in patients with allergy to sulphonamides -LevobunololBimatoprostBrinzolamideBrimonidine  <response>: Ans. is c i.e., Brinzolamide Acetazolamide, Dorzolamide and Brinzolamide are sulfonamide derivatives which act by inhibiting carbonic anhydrase carbonic anhydrase inhibitor. Being sulphonamide derivatives they are contraindicated in patients with allergy to sulphonamides. 