<prompt> All are true about Primary sclerosing cholangitis exceptAssociated with ulcerative colitisPredisposition to cholangiocarcinomaPredisposition gallbladder cancerMost common presentation is jaundice  <response>: Primary sclerosing cholangitisThis condition often presents in young adults with mild non-specific symptoms, and biliary disease is suggested by the finding of abnormal liver function tests. Rarely, the first presentation is with jaundice due to biliary obstruction.Although the aetiology is unknown, a genetic predisposition is likely, owing to its association with ulcerative colitis UC. In patients with primary sclerosing cholangitis PSC and UC, the condition usually progresses even if the diseased colon is removed.There is a strong predisposition to cholangiocarcinoma CCA and gallbladder cancerRef: Bailey and love 27e pg: 1167 