<prompt> Which of the following agents causing acute infectious diarrhea can be paired with the pathogenic mechanism of enterotoxic, enteropathogenic, enteroinvasive and enterohemorrhagic effects?Vibrio choleraeE. coliShigellaRotavirus  <response>: E. coli, a gram negative rod commensal in the gastrointestinal tract, has various pathogenic strains which cause illness on various ways. Enterotoxic E. coli ETEC causes the travelers disease; enteropathogenic enteroadherent E. coli EPEC causes childhood diarrhea, enteroinvasive E. coli EIEC causes dysentery-like disease, and enterohemorrhagic E. coli EHEC causes hemorrhagic colitis and hemolytic uremic syndrome in children. Normal individuals become ill when exposed to ceain pathogenic strains. The heat labile toxin of E. coli causes cAMP increase and increased excretion of electrolytes. The heat stable toxin stimulates guanylyl cyclase in the intestinal mucosal cells. Ref: Ray C.G., Ryan K.J. 2010. Chapter 33. Enterobacteriaceae. In C.G. Ray, K.J. Ryan Eds, Sherris Medical Microbiology, 5e. 