<prompt> In which of the following disorders is administration of barbiturates contraindicated inAnxiety disordersAcute intermittent porphyriaKernicterusRefractory status epilepticus  <response>: Contraindications of barbiturates: Acute intermittent porphyria- Barbiturates exacerbate it by inducing microsomal enzymes d aminolevulinic acid synthetase and increasing porphyrin synthesis. Liver and kidney disease Severe pulmonary insufficiency e.g. emphysema Obstructive sleep apnoea Uses of barbiturates: Anxiety disorders Epilepsy Kernicterus Congenital nonhemolytic jaundice : Phenobarbitone induces conjugation of bilirubin and hastens clearance of jaundice. 