<prompt> Metoclopramide:Inhibit cholinergic smooth muscle stimulation in the gastrointestinal tractDecrease lower esophageal sphincter pressureStimulate D2 receptorEnhance colonic motility  <response>: Ans. D Enhances colonic motilityRef: Katzung 10e p1021; KDT 8the p713Metoclopramide is a D2 receptor antagonist that increases cholinergic activity by inhibiting presynpatic D2 receptors in GIT D2 receptor stimulation inhibits the release of ACh.It increase LES tone that is also responsible for anti-emetic action.It does not significantly increase colonic motility.But out of the four options, this is the best answer, because although not significantly but it can increase colonic motility, whereas other options are definitely wrong. 