<prompt> Shock is clinically best assessed by -Urine outputCVPBPHydration  <response>: Shock: Inadequate delivery of oxygen and nutrients due to poor tissue perfusion to maintain normal tissue and cellular function Mean arterial pressure 60 mm Hg in previously normotensive patients Systemic vascular resistance rises leading to decreased cutaneous blood flow and autoregulation is critical in sustaining cerebral and coronary blood flow. 