<prompt> Chromosomal mutation in low grade transitional cell cancer of bladder is?P53Rb geneFGFR3HRAS  <response>: Ans. c FGFR3Ref: Robbins 9th968Noninvasive high-grade urothelial carcinoma is associated with loss of the TP53 and RB tumor suppressor genes while Noninvasive low-grade papillary urothelial carcinoma is associated with gain of function FGFR3 and HRAS mutations. 