<prompt> Cardiotoxicity of bupivacaine -Depressed pacemaker activityToxic compound damaging myocardial cellsDepressed neural control on heaVascular thrombosis and Myocardial ischemia  <response>: Ans. is a i.e., Depressed pacemaker activity o Local anaesthetics block cardiac sodium channels and thus depress abnormal cardiac pacemaker activity, excitability, and conduction. At extremely high concentrations, local anaesthetics can also block calcium channels. 