<prompt> Acantholysis is due to destruction of :EpidermisSubepidermisIntercellular substanceBasement membrane  <response>: Ans. is c Intercellular Substance It is loss of cohesion bw epidermal cells due to destruction of intercellulare substance. IgG Antibodies are formed against the intercellular substance.Acantholysis occurs in stratum Basale in Pemiphus VulgarisAcantholysis is demonstrated by Nikolskys signAcantholytic cells are demonstrated by Tzanck smear 