<prompt> Gene of wilsons disease is -ATP 7AATP7BADP7AADP7B  <response>: Ans. is b i.e., ATP 7B o Wilson disease is an autosomal recessive disorder caused by mutation of the ATP7B gene, resulting in impaired copper excretion into bile failure to incorporate copper into ceruloplasmin.Wilson diseaseo This autosomal - recessive disorder is marked by the accumulation of toxic levels of copper in many tissues and organs, principally the liver, brain and eye.Clinical features of Wilsons disease-Organs involvedSymptoms producedHepatico The liver often bears the brunt of injury in wilson disease with hepatic changes ranging from relatively minor to massive damage which are - Fatty change, acute hepatitis, chronic hepatitis, cirrhosis, massive liver necrosis acute fulminant hepatitis,o All forms of hepatitis are seen in wilson s disease chronic active hepatitis also seenCN.So In brain, the toxic injury primarily affects the basal ganglia particularly the putamen which demonstrates atrophy and cavitation.o The involvement of basal ganglia produces extrapyramidal symptoms which are - Dystonia, incoordination, tremor dysphagia, dysarthria, chorea.o Memory loss, migraine headaches and seizures too can occur.o Patients can have difficulty in concentrating on tasks but cognition is usually not impaired,o Remember that Sensor- abnormalities and muscular weakness are not seen in this disease.Psychiatrico HO of behavioral disturbances within five years of the onset of the disease. 3 Features are diverse and include loss of emotional control temper tantrums, crying bouts Depression, hyperactivity, loss of sexual inhibition.Occularo Kayser Flescher ring green to brown deposits in the descmenfs membrane in the corneao Sunflower cataractBloodo Hemolytic anemia in severe hepatic failure hemolytic anemias may occur because large amounts of copper are released. The association of hemolysis and liver disease makes wilson disease likely diagnosis.Otherso Urinary excretion of glucose, phosphates, amino acids, urates 