<prompt> In sebaceous glands accumulation of sebum leads to -MilliaAcneEpidermoidcystMilliria  <response>: Ans. is b i.e., Acne o Acne results from a change in the keratinization process. Ducts of pilosebaceous glands have their opening into hair follicles and hair follicles open on skin surface by their hair follicle opening. Therefore blockage of hair follicle opening results in blockage of the pilosebaceous gland. This is the main pathogenic factor in acne vulgaris,o Three basic defects lead to the development of acne vulgaris : -i Increased sebum secretionii Follicular plug at hair follicle opening.iii Bacterial infection.Increased hormonal secretion at pubertyespecially testosterone dihydrotestosteroneIncreased activity of pilosebaceous glandsIncreased lipid-rich sebum secretionProliferation of PropionibacteriumInduced by lipid-rich sebumPropionibacterium produces lipaseLyses of TG release of FFAFFA cause increased follicular keratinizationFollicular plugObstruction of hair follicle openingObstruction to the flow of sebumAbout other optionso An epidermoid cyst is a keratin-containing cyst lined by the epidermis. It develops due to the proliferation of surface epidermal cells into the dermis,o Mi Ilia is a miniature epidermoid cysto Milliria arises due to blockage of sweat glands. 