<prompt> Zero order kinetics is independent of:Plasma concentrationClearanceVolume of distributionHalf life  <response>: Plasma concentration REF: Katzungs pharmacology 10th edition page 38 See APPENDIX-33 for Chemical kinetics of drugs Drugs may follow zero order, first order or second order kinetics. It depends on following formula: Rate of elimination a degrl Thus for zero order kinetics, rate of elimination is independent of plasma concentration. 