<prompt> Which of the following is associated with 20 risk of chromosomal anomalies?Cleft lipGastroschisisOmphaloceleSpina bifida  <response>: Omphalocele is a membrane-covered herniation of abdominal contents into the base of the umbilical cord; the incidence is 2 per 10,000 live bihs 0.02. Over 50 of cases have either an abnormal karyotype or an associated syndrome. The sac may contain liver and spleen as well as intestine. Prognosis varies with the size of the lesion, with the presence of pulmonary hypoplasia and respiratory insufficiency, and with the presence of associated abnormalities. Ref: Thilo E.H., Rosenberg A.A. 2012. Chapter 2. The Newborn Infant. In W.W. Hay, Jr., M.J. Levin, R.R. Deterding, J.J. Ross, J.M. Sondheimer Eds, CURRENT Diagnosis Treatment: Pediatrics, 21e. 