<prompt> Keshans disease due to deficiency of:SeleniumIronCopperZinc  <response>: Ans. a. SeleniumIMPORTANT MINERALS--FUNCTIONS AND DEFICIENCY MANIFESTATIONMineralFunctionsDeficiencyCobaltChromiumConstituent of Vit B12 Potentiate the action of InsulinMacrocytic anemia Impaired glucose toleranceFluorideIodineConstituent of Bone and teeth Thyroid hormone SynthesisDental cariesThyroid enlargement, T4, cretinismMolybdenumCofactor for. Xanthine oxidase. Sulfite oxidase. Aldehyde oxidaseSevere neurologic abnormality, xanthinuriaSeleniumCofactor for. Glutathione peroxidase. Deiodinase. Thioredoxin reductase. Antioxidant along with Vit. EKeshans disease cardiomyopathy, heart failure, striated muscle degenerationZincCofactor for. Carbonic anhydrase. Carboxypeptidase. Lactate dehydrogenase. Alcohol dehydrogenase. Alkaline phosphateGrowth retardation, decrease taste and smell dysaesthesia, alopecia, dermatitis, diarrhea, immune dysfunction, failure to thrive, gonadal atrophy, congenital malformation, impaired would healingManganeseCofactor for. Arginase. Carboxylase. Kinase. Enolase. Glucosyltransferase. Phospho gluco mutase. Required for RNA polymeraseImpaired growth and skeletal development, reproduction, lipid and carbohydrate metabolism, upper body rash 