<prompt> Which vitamin deficiency is responsible for neonatal seizure -PyridoxineVitamin CThiamineCobalamin  <response>: Ans. is a i.e., Pyridoxin o Pyridoxine Vitamin B6 dependency with seizures is an autosomal recessive condition. o It is due to GABA deficiency in the brain, which is presumbly caused by decreased activity of GAD glutamic acid decarboxylase. o Administration of large doses of pyridoxin usually results in a dramatic improvement of both seizures and EEG abnormalities, as pyridoxin acts as a cofactor for GAD and improves its activity. 