<prompt> In the management of pulmonary emboli, alteplase -PA is infused for:-1-3 hours4-6 hours7-9 hours10-12 hours  <response>: Alteplase : Also known as -PARecombinant tissue plasminogen activator Has more affinity towards plasminogen bound to fibrin Due to sho duration of action, it is given by continuous iv infusion. The doses are: For MI: 15 mg iv bolus followed by 50 mg over 30 min and then 35 mg over next 60 min. For Pulmonary embolism: 100 mg iv over 2 hours For Ischemic stroke: 0.9 mgkg iv over 60 min Note : Tenecteplase can be given as a single bolus dose for coronary thrombolysis. 