<prompt> Ecadherin Gene deficiency is seen inGastric cancerIntestinal cancerThyroid cancerPancreatic cancer  <response>: ref Robbins 8e p96; 9e p297 Cadherins are derived from the calcium dependant adherence protein.it paicipate in interaction between cells of same type The linkage of cadherins with the cytoskeleton occurs through catenins .the cell to cell interaction mediated by cadherins and catenins play a differentiation and account for the inhibition of cell proliferation that occurs when cultured normal cells contact each other 