<prompt> Even in large dosages used in malaria, quinine does not cause toxicity, because :It enters in fat cellsElevated plasma alpha acid glycoproteinDeposited in infected RBCsExcreted rapidly in urine  <response>: Ans. is b elevated plasma alpha acid glycoprotein. Patient with malaria can achieve high plasma level of quinine with few signs of toxicity because of the elevated plasma alpha 1 acid glycoproteins, produced during acute phase of infection. It prevents quinine toxicity through binding of most of the drug in the plasma.Peak plasma level which a person can achieve without producing toxicity.a. in severely ill patients -15-20 mglitreb. in persons without malaria - 10 mglitreAbout quinineIt is an erythrocytic schizonticideUsed for treatment of multidrug resistant strains of P. falciparumAssociated with a triad of dose related toxicitiesCinchonismHypotensionHypoglycemia 