<prompt> High plasma protein binding of a drug results inLess drug interactionHigh volume of distributionDecreased glomerular filtrationLowers duration of action  <response>: Most drugs bind to plasma proteins in a reversible fashion without translating into a pharmacological response. Plasma proteins are hence called Silent Receptors Acidic drugs bind to Albumin, Basic drugs to alpha1 acid- glycoprotein. Binding of the drug to plasma protein affects the pharmacokinetic handling of drug by the body. Ref:- HL KK Sharmas Principles of Pharmacology 3rd Ed; Pg Num:- 48 