<prompt> Secondary structure of prion proteins in prion disease like Creutz feldt-Jakob disease CJD isBeta sheetsBeta bendBeta turusAlfa helix  <response>: Beta sheets Prions are caused by human prion related protein PrP a glycoprotein rich in a helix. PrP is endogenous to the host and in most people, the PrP protein folds normally leaving the person healthy. Rarely, a mutation in the PrP gene will allow the protein to be made incorrectly and it will fold incorrectly making a PrPsc prion. Which is a Rlycoprotein rich in ,beta sheets. Remember PrP -- Made up of a helixo PrPse -- Made up of 13 shee Pathoeenesis of Prions disease Normal endogenous human protein human prion related protein PrP It is a glycoprotein rich in a helix and it folds normally Mutation in the PrP protein Folds improperly and result in PrPsc protein It is a glycoprotein rich in sheets PrPsc comes in contact with PrP PrP too will fold uncorrectly resulting in more PrPsc Aggregation of PrPsc Destruction of nervous tissue Prion disease 