<prompt> Which of the following condition is associated with increased VMA?RhabdomyosarcomaPheochromocytomaNephroblastomaRCC  <response>: Ans. is b i.e., Pheochromocytoma Vanillylmandelic acid VMA is an end-stage metabolite of the catecholamines, epinephrine, and norepinephrine. Urinary VMA, along with other catecholamine metabolites, including homovanillic acid HVA, metanephrine, and normetanephrine are elevated in patients with tumors that secrete catecholamines eg, neuroblastoma, pheochromocytoma, or other neural crest tumors. These tests are used to diagnose neuroblastomas, and to monitor treatment of these conditions. Elevated values of homovanillic acid HVA, vanillylmandelic acid VMA, and other catecholamine metabolites eg, dopamine may be suggestive of the presence of a catecholamine-secreting tumor. 