<prompt> Paralysis of 3rd, 4th, 6th nerves with involvement of Ophthalmic division of 5th nerve, localizes the lesion to-Cavernous sinusApex of orbitBrainstemBase of skull  <response>: Paralysis of 3rd, 4th, 6th nerve and involvement of Ophthalmic division of 5th nerve - cavernous sinus thrombosis. Paralysis of 3rd, 4th, 6th nerve, Ophthalmic division of 5th nerve plus optic nerve signs - orbital apex syndrome. Ref: Khurana 7the p.428 