<prompt> A patient came to eye OPD with ho dactylitis, anemia and growth retardation. In fundus there is sea fan neovascularization and salmon patches. What is the probable diagnosisSyphillisSickle cell anemiaToxoplasmaHistoplasmosis  <response>: The presentation is typical of sickle cell retinopathy Sickle cell Retinopathy SS genotype causes more severe systemic disease than SC and S-Thal genotypes, while the SC and S-Thal genotypes present with a greater incidence of ocular manifestations, including proliferative sickle cell retinopathy. The underlying systemic and ocular manifestations of SCD Sickle Cell Disease are a result of vaso-occlusive ischemia due to the blocking of blood vessels by sickle-shaped erythrocytes. Figure 1. Salmon-patch Figure 2. Sea fan formation with neovascularization. 