<prompt> Fluconazole is more effective than itraconazole in the following systemic fungal diseasePulmonary histoplasmosisCryptococcal meningitisNon-meningeal blastomycosisDisseminated sporotrichosis  <response>: Ref-KDT 6e p763,764 Fluconazole has maximum CNS penetration whereas itraconazole has limited entry in the brain. Therefore fluconazole is preferred over itraconazole for the treatment of cryptococcal meningitis. For all other conditions listed in the question, itraconazole is first choice drug. 