<prompt> PPIs are use used in -ZE syndromeNSAIDs induced peptic ulcerGastroesophageal refluxAll of the above  <response>: Ans. is d i.e., All of the above o PPI are the DOC for peptic ulcer gastric or duodenal, GERD, ZE syndrome, prevention of aspiratory pneumonia and NSAID induced gastric duodenal ulcers. Note - PGE1 analogue Misoprostol is specific drug for prevention and treatment of NSAID induced ulcer, but DOC is PPI. 