<prompt> A 60-year-old woman presents with generalized edema, skin ulceration and hypeension. Urine examination shows subnephrotic proteinuriaPost-streptococcal GlomerulonephritisEssential Mixed CryoglobulinemiaMembranoproliferative Glomerulonephritis MPGNFocal SegmentalGlomerulosclerosis FSGS  <response>: Answer is B C Essential mixed cryoglobulinemia: The presence of skin ulceration on clinical examination in a female patient around the 6th decade ors a diagnosis of Essential Mixed Cryoglobulinemia over MPGN. Neveheless if Essential Mixed Cryoglobulinemia were not amongst the options MPGN would be the single best answer of choice. Membranoproliferative glomerulonephritis is a responsible for 80 of all renal lesions in essential mixed cryoglobulinemia. 