<prompt> Chediak-Higashi syndromeDisorders of specific immunityDisorders of complementDisorders of phagocytosisSecondary immunodeficiencies  <response>: i.e. Disorders of phagocytosis: 159-Ananthanarayan 8thCHEDIAK - HIGASHI SYNDROME: This is a genetic disorder characterised by decreased pigmentation of skin, eyes and hair, photophobia, nystagmus and giant peroxidase positive inclusions in the cytoplasm of leucocytes. The inclusion may be the result of autophagocytic activity. The leucocytes possess diminishedphagocytic activity. Patients suffer from frequent and severe pyogenic infectionsClassification of Primary immunodeficiency syndromeA. Disorders of specific immunityI. Humoral immuno deficiencies B-cell defectsa. X-linked agammaglobulinemiab. Transient hypogammaglobulinemia of infantsc. Common variable immunodeficiencies late onset hypogamma globulinemiad. Selective immunoglobulin deficiencies IgA, IgM or IgG subclassese. Immunodeficienceis with hyper-IgMf. Transcobalamin II deficiencyII. Cellular immunodeficiencies T-cell defectsa. Thymic hypopolasia Digeorge syndromeb. Chronic mucocutaneous candidiasisc. Purine nucleoside phosphorylase PNP deficiencyIII. Combined immuno deficiency B and T cell defectsa. Cellular immuno deficiency with abnormal immunoglobulin synthesis Nezel of Syndromeb. Ataxia - telangiectasiac. Wiskott - Aldrich syndromed. Immuno deficiency with thymomae. Immuno deficiency with short -limbed dwarfismf. Episodic lymphopenia with lymphocytotoxing. Severe combined immuno deficiencies1. Swiss type agammaglobulinemia2. Reticular dysgenesis of de Vail3. Adenosine deaminase ADA deficiencyB. Disorders of complementa. Complement component deficienciesb. Complement inhibitor deficienciesC. Disorders of phagocytosisa. Chronic granulomatous diseaseb. Myeloperoxidase deficiencyc. Chediak - Higashi syndromed. Leucocyte G6PD deficiencye. Jobs syndromef. Tuftsin deficiencyg. Lazy leucocyte syndromeh. Hyper - IgE syndromei. Actin - binding protein deficiencyj. Shwachmans diseaseSecondary Immuno deficiencies - arise when infections HIV, drugs immuno suppressive agents, corticosteroids, nutritional inadequacies Kwashiorkor, metabolic disorders protein losing enteropathies and malignancies CLL, Multiple myeloma, Hodgkins disease leads to defects in specific and nonspecific immunity. 