<prompt> Histological benign lesion can be fatal ifInduce organ dysfunctionTransform to carcinomaMetastasize to different organsAll of the above  <response>: CharacteristicsBenignMalignantDifferentiation Well differentiated; structure may be typical of tissue of origin Some lack of differentiation with anaplasia; structure is often atypicalRate of growth Usually progressive slow; may come to a standstill or regress; mitotic figures are rare normal Erratic may be slow to rapid; mitotic figures may be numerous abnormal Local invasion Usually cohesive expansile well-demarcated masses that do not invade or infiltrate surrounding normal tissuesLocally invasive, infiltrating the surrounding normal tissues; sometimes may be seemingly cohesive expansile Metastasis Absent Present; the larger and more differentiated the primary , the more likely are metastases 