<prompt> Which of the following has the potential of undergoing Spontaneous malignant transformation?OsteomalaciaAlbrights syndromePagets disease of bonesOsteogenesis imperfecta  <response>: Complications of the Pagets disease include stress fractures and secondary sarcomas. Poor mechanical properties of pagetic bone results in incomplete stress fractures. Fractures occur most commonly in the femur followed by other stress-bearing bones such as tibia, humerus, spine, and pelvis. Osteosarcomas and to a lesser extent, chondrosarcomas and fibrosarcomas are the most serious complications of Pagets disease. Prognosis of polyostotic Pagets disease is less favourable than monostotic disease. Patients with polyostotic disease are at higher risk of complications.Reference: Shafers Textbook of ORAL PATHOLOGY Eighth Edition page no 471,473 