<prompt> Most common route of transmission of hepatitis C:IV drug abuseSexual contactFactor 8 concentrateFeco-oral route  <response>: Screening of donated blood for HCV antibody has decreased the risk of transfusion-associated HCV infection Persons who inject illegal drugs with non-sterile needles or who sno cocaine with shared straws are at highest risk for HCV infection. In developed countries, most new HCV infections are related to intravenous drug abuse IVDA. 