<prompt> Protein acts as buffer due to which propeyColloidBasicAcidicAmphipathic amphoteric in nature  <response>: Most biomolecules are amphipathic; that is, they possess regions rich in charged or polar functional groups as well as regions with hydrophobic character. Proteins tend to fold with the R-groups of amino acids with hydrophobic side chains in the interior. Amino acids with charged or polar amino acid side chains. Ref: Harpers Illustrated Biochemistry, 30E 2015 Pg No 8. 