<prompt> How will you decrease aminoglycoside toxicity?Total dose ODTotal dose BDLow dose ODLow dose BD  <response>: Ans. is a i.e., High dose OD Authoities recommend giving a single total daily dose regime for aminoglycosides for patients with normal renal function. This is based on the following considerations: 1 Aminoglycosides exe concentration dependent bactericidal action and a long post antibiotic effect, therefore higher plasma concentrations attained after the single daily dose will be equally or more effective than the divided doses. 2 With the single daily dose the plasma concentration will remain subthreshold for ototoxicity and nephrotoxicity for a longer period each day allowing washout of the drug from the endolymph and renal coex, thus decreasing the toxic effects. 