<prompt> First change of improvement noted after iron therapy is initiated -Decreased irritabilityReticulcytosisIncrease in serum iron levelsReplenishment of iron stores  <response>: Ans is a i.e., Decreased irritabilityWhen specific iron therapy is given, patients often show rapid subjective improvment, with disappearance or marked diminution offatigue, lassitude, and other nonspecificc symptoms e.g. irritability. This response may occur before any improvement in anemia observed Wintrobeso The earliest hematological evidence of response of treatment is an increase in the percentage of reticulocytes and their hemoglobin content.o So, Overall earliest indicator of improvement decreased fatigue, lassitude and other nonspecific symptoms Earliest hematological evidence of improvement --- Increased reticulocyte count. 