<prompt> Amyloid-rich stroma was seen on HE stain of a thyroid nodule as shown below. What would be the diagnosis?Medullary thyroid carcinomaSystemic amyloidosisThyroid lymphomaPapillary thyroid carcinoma  <response>: Medullary Carcinoma of thyroid MCT Arise form para follicular C Cells Derived from - Ultimobranchial bodies Secretes - calcitonin Level of calcitonin is raised Level of calcium is normal Clinical Features Midline swelling in anterior pa of neck Characteristic features Raised calcitonin History of diarrhea Presence of amyloid stroma Positive family history of Pheochromocytoma Hyperparathyroidism due to association with MEN 2A MEN 2B 