<prompt> Severe combined immunodeficiency is seen with:Pre B- CellPre T CellBothNK Cell  <response>: Ans. c BothRef Microbiology by Ananthanaray an and Paniker 9th ed. 174 Severe combined immunodeficiency SCID syndrome has impairment of both humoral and cell mediated immunity B and T cell defect. Inheritance pattern of SCID is X-Iinked recessive Autosomal recessive.Clinical Manifestation of SCID Oral candidiasis in infants Recurrent infection with candidia albicans, RCarinii, CMV, varicella. Organs like lymph nodes, tonsils, peyers patches are absent. Very small thymus gland Poor survival rate. 