<prompt> NSAIDS cause gastric ulcer because-They inhibit COX - 2 enzymeThey inhibit mucus productionThey increase HCI productionThey delay gastric emptying  <response>: Ans. is b i.e., They inhibit mucus production o Normally, gastric mucosal PGs are produced by COX - 1. o Prostaglandins function as natural ulcer protectives by enhancing gastric mucus and HCO3- production, as well as by improving mucosal circulation and health. The ulcerogenic action of NSAIDs may be due to loss of this protective influence. o PGE analogues are cytoprotective at low doses and inhibit gastric acid secretion at higher doses. NSAIDs inhibit prostaglandin secretion and thus antagonizes its cytoprotective effect. o Misoprostol is used in NSAIDs induced ulcers. 