<prompt> Regarding breast cancer all are true except:Increased incidence with increase in ageMedullary carcinoma with high mitotic index has poorest prognosisInvolvement of subdermal lymphatics carries poor prognosisIncrease in incidence with estrogen exposure  <response>: Most impoant risk factor for malignancy: Increasing Age Most conspicuous sign of Breast Cancer: Peau D Orange- cause is lymphatic permeation by tumor cells -increase risk of lymph node metastasis - increases risk of distant metastasis Hyperestrogenemia like in nulliparity late first full-term pregnancy, early menarche, late menopause - increases risk of Breast Cancer Type of Breast Cancer with worst poorest prognosis - Inflammatory Breast Cancer Aka Mastitis Carcinomatosa 