<prompt> 1722. A patient presents with macroglossia and atrophy of tongue papilla. His Hb Is 11.5 and MCV is 100. What should be the next step in Investigating this patient ?B12 estimationBrush biopsy of the lesionFluconazole treatmentIncision biopsy  <response>: Deficiency of vit B12 folate presents with anemiamacrocytic megaloblastic anemia, glossitissmooth,beefy,red tongue.Hb level will be below normal range MCV wil be elevated.So this is a case of vit B 12 deficiency next choice of investigation is serum Vit B12 assay. Harsh mohan textbook of pathology sixth edition pg no 306 