<prompt> Which of the following regarding sickle cell disease is false?Single nucleotide change results in change of Glutamine to ValineSticky patch is generated as a result of replacement of a nonpolar residue with a polar residueHbS provides resistance against malariaBinding of deoxyHbA terminates fiber polymerization  <response>: In HbS, the nonpolar amino acid valine has replaced the polar surface residue Glu6 of the β subunit, generating a hydrophobic sticky patch on the surface of the β subunit of both oxyHbS and deoxyHbS.Ref: Harpers illustrated biochemistry. 30th edition page no: 56 