<prompt> Integrin is associated with all ExceptRollingAdhesionArrestTransmigration  <response>: The rolling leukocytes are able to sense changes in the endothelium that initiate the next step in the reaction of leukocytes, which is firm adhesion to endothelial sur- faces. This adhesion is mediated by integrins expressed on leukocyte cell surfaces interacting with their ligands on endothelial cells Fig. 2-5 and Table 2-2. Integrins are transmembrane heterodimeric glycoproteins that mediate the adhesion of leukocytes to endothelium and of various cells to the extracellular matrix. They are normally expressed on leukocyte plasma membranes in a low- affinity form and do not adhere to their specific ligands until the leukocytes are activated by chemokines. Integrins and Integrin Ligands ICAM-1 immunoglobulin family CD11CD18 integrins LFA-1, Mac-1 Firm adhesion, arrest, transmigration VCAM-1 immunoglobulin family VLA-4 integrin Adhesion Ref Robbins 9e p35_36 