<prompt> Earliest abnormality of diabetes nephropathy is-HyperfiltrationMicroalbuminuriaHypeensionProteinuria  <response>: At the onset of diabetes, renal hyperophy and Glomerular hyperfiltration are present . Earliest abnormality is Glomerular hyperfiltration and earliest manifestation is abluminuria. In 40of patients with diabetes who develop diabetic nephropathy ,the earliest manifestation is an increase in abluminuria detected by sensitive radioimmunoassay. Microalbuminuria appears 5-10 yrs after the onset of diabetes. Ref:Harrison 20 th edition pg no 2145 