<prompt> Which among the following statements is wrongLight chains are synthesised in slight excess normally in plasma cellsQualitative assessment of M component can be done by electrophoresisM components are detected in chronic myeloid leukaemiaIn 20 myelomas, only light chains are produced  <response>: Qualitative assessment of M component is done by immune electrophoresis. Electrophoresis is used for quantitative assessment of M component. M component can also be detected in other lymphoid malignancies, CML, Can breast, colon cancer , non neoplastic condition like cirrhosis, sarcoidosis, rheumatoid ahritis, myasthenia gravis. Ref : Harrisons Principles of Internal Medicine, 21st Edition, p 710-712. 