<prompt> Which of the following is the characteristic of a highly ionized drug?High protein bindingCan cross placental barrier easilyRapidly absorbed from stomachExcreted mostly by the kidneys  <response>: A highly ionized drug is not reabsorbed by the tubules and is easily excreted by the kidneys because it is lipid insoluble. Ref: Dr J G Buch, 2010 Chapter 3, Pharmacokinetics, Clinically oriented pharmacology, Newdelhi, Page 13 