<prompt> A cardiologist wants to study the effect of an antihypertensive drug. He notes down the initial systolic blood pressure mmHg of 50 patients and then administers the drug on them. After a weeks tretment, he measures the systolic blood pressure again. Which of the following is the most aproprate statistical test of significance to test the statistical significance of the change in blood pressure -Paired t-testUnpaired or independent t-testAnalysis of varianceChi-square test  <response>: In the given question, a cardiologist wants to study the effect of an anti-hypertensive drug. So he will compare mean BP of 50 patients before and after administering the drug. Thus Paired t-test will be most appropriate test of significance 