<prompt> Which virus is implicated in Burkits lymphoma?EBVHTLVHPVHHV8  <response>: Refer: Robbins Pathologic Basis of Disease, 8thedition, pg no: 314, 607Burkitts lymphomaThere are three clinical types:African endemic Burkitt lymphoma.Sporadic nonendemic Burkitt lymphoma.Aggressive lymphomas associated with HIV.These 3 types are histologically identical.ImmunophenotypeThese are tumors of mature B cells.It express surface IgM, CD19, CD20, CD10 and BCL6.Molecular PathogenesisAll forms of Burkitt lymphoma are associated with translocationsof the c-MYC gene on chromosome 8.The translocation partner is usually the IgH locus t8;14 butmay also be the Ig k t2;8 or y t8;22 light-chain loci.All endemic tumors are latently infected with EBV, which is alsopresent in about 25 of HIV-associated tumors and 15 to20 of sporadic cases. 