<prompt> ANCA is found in all exceptWegeners granulomatosisChurg-Strauss syndromeMicroscopic PolyangitisBacterial Vasculitis  <response>: D Bacterial vasculitis ANTI-NEUTROPHIL CYTOPLASMIC ANTIBODIES ANCA are antibodies directed against certain proteins in cytoplasm of neutrophils. It is of two types:i Cytoplasmic c ANCA: Refers antibodies against proteinase-3 in azurophilic granules. It is found in - wegers granulomatosisii Perinuclear p ANCA: Refers antibodies against myeloperoxidase major target, elastase, cathepsin G, Lactoferin, Lysozyme. ANCA is found in: PAN, Microscopic polyangitis, Churg-Strauss syndrome, Crescentic GN, Good-pastures syndrome Non vascular causes like rheumatic and non-rheumatic autoimmune diseases, IBD, drugs, endocarditis, bacterial infections in patient of cystic fibrosis, primary sclerosing cholangitis etc. There are three primary diseases that are consistently associated with ANCA: Wegeners granulomatosis, microscopic polyangiitis, and glomerulonephritis. The antibodies are assumed to be involved in the generation andor progression of lesions and clinical signs. Classically, c-ANCA is associated with Wegeners granulomatosis; p-ANCA is associated with microscopic polyangiitis arid focal necrotizing and crescentic glomerulonephritis. However, in recent years ANCA targeted against other autoantigens have been identified. Patients with a number of other diseases, such as ulcerative colitis and Ankylosing spondylitis, will commonly have ANCA as well. However in these cases there is no associated vasculitis, and the ANCA are thought to be incidental or epiphenomena rather than part of the disease itself. Churg-Strauss syndrome is associated with p-ANCA directed against MPO. 