<prompt> Drug induced lupus can be identified by:Anti-histone antibodiesDouble stranded DNA antibodiesAntinuclear antibodiesAnti-SM antibodies  <response>: Anti-histone antibodies are positive in 50-100 of the patients with drug induced lupus. The drugs most commonly associated with DIL are: ? Procainamide ? Hydralazine ? Quinidine ? Isoniazid So anti-histone antibodies are the single best answer of choice. Ref: Harrisons Principles of Internal Medicine, 16th Edition, Page 1961; Systemic Lupus Erythematosus By Robe G. Lahita, George Sokos, Jill P, Buyon, Takao Koike. 