<prompt> Whipples is disease is caused by:BacteroidesAcinetobacterH. pyloriTropheryma whippelii  <response>: Ref: Harrison 19th ed. P 1092-93 Whipples disease is a malabsorption syndrome caused by Tropheryma whippelii. It is an intracellular bacteria found in gut macrophages.Mnemonic: WHIPPLEWeight lossHyperpigmentationInfection with Tropheryma whippeliiPAS positive granules in macrophagesPolyarthritisLymphadenopathySteatorrheaIOC for Whipples disease is small intestinal biopsy.Most common heart valve involved in Whipples disease is aortic valve.Culture negative endocarditis is seen with duke criteria not being satisfied.CNS features are in form of cognition defect progressive to dementia.MC extraintestinal manifestation of Whipples disease is CNS feature of dementia.Current treatment is ceftriaxone for 2 weeks and oral doxycycline for 1 year. 