<prompt> A patient with necrotizing pancreatitis undergoes CT guided aspiration, which results in growth of E-coli on culture. The most appropriate treatment is:Culture appropriate antibiotic therapyERCP with sphincterotomyCT guided placement of drainsExploratory laparotomy  <response>: Exploratory laparotomy The presence of secondary pancreatic infection suspected in patients whose systemic inflammatory response fever, WBC count or organ dysfunction fails to resolve, CT-guided aspiration of fluid from pancreatic bed for performance of Grams stain culture analysis is of critical impoance. A positive is Grams stain or culture or identification of gas within pancreas on CT-scan, mandate operative intervention. 