<prompt> Co-translational inseion is seen withTransloconChaperonsUbiquitinMannose 6- P  <response>: The signal hypothesis states that protein is inseed into ER membrane at the same time its mRNA being translated on polyribosomes known as co-translational inseion . This is translocation endoplasmic reticulum. Components: N terminal signal peptide: Polyribosomes SRP SRP-R Sec 61 translocon TRAM TRAP proteins Reference: Harper; 30th edition 