<prompt> Indicate the drug which does not improve lower esophageal sphincter tone or prevent gastroesophageal reflux, but is used as the first line treatment of gastroesophageal reflux disease:Sodium alginatealuminium hydroxide gelOmeprazoleMosaprideMetoclopramid  <response>: Ref: KDT 6e p648 Treatment of GERD can be acomplished by Increasing GI motility with prokinetic drugs like metoclopramide and mosapride or By decreasing gastric acid secretion with PPIs like omeprazole. 