<prompt> Gall blader stone formation in influenced by AJE -Clofibrate therapyHyperalimentationPrimary biliary cirrhosisHypercholesterolemia  <response>: Hyper alimentation - decreases gall bladder motility, promotes stasisPrimary biliary cirrhosis - decreases bile salt secretion into bileClofibrate therapy - increases biliary cholesterolthus these factors predispose to cholesterol stone formation.Predisposing factors for cholesterol gall stone formation are1. Demographicgenetic factorsPrevalence highest in North American Indians, Chilean Indians and Chilean Hispanics, greater in Northern Europe and North America than in Asia, lowest in Japan; familial disposition; hereditary aspects.2. ObesityNormal bile acid pool and secretion but increased biliary secretion of cholesterol3. Weight lossMobilization of tissue cholesterol leads to increased biliary cholesterol secretion while enterohepatic circulation of bile acid is increased4. Female sex hormonesEstrogens stimulate hepatic lipoprotein receptors, increases uptake of dietary cholesterol, and increase biliary cholesterol secretionNatural estrogens, other estrogens, and oral contraceptives lead to decreased bile salt secretion and decreased conversion of cholesterol to cholesteryl esters.5. Increasing ageIncreased biliary secretion of cholesterol, decreased size of bile acid pool, decreased secretion of bile salts.6. Gallbladder hypomotility leading to stasis and formation of sludgeProlonged parenteral nutritionFastingPregnancyDrugs such as octreotide7. Clofibrate therapyIncreased biliary secretion of cholesterol8. Decreased bile acid secretionPrimary biliary cirrhosisGenetic defect of the CYP7A1 gene9. Decreased phospholipid secretionGenetic defect of the MDR3 gene10. MiscellaneousHigh-calorie, high fat dietSpinal cord injury 