<prompt> Chloroquine related eye disease risk is high in all except -Total cumulative dose 460 gDaily dose 3 mgkg or 250 mg dayIn patients with kidney dysfunctionIntake for 2 years  <response>: Ans. is d i.e., Intake for 2 years Chloroquine is used to treat malaria and certain connective tissue disorders.Chloroquine has serious irreversible toxic effects on the retina resulting inDecreased visual acuityBlurred visionDiplopiaImpaired colour visonDecreased night visionVisual filed defectsThe chloroquine maculopathy begins insidiously and its features include: - - Fine mottling of the maculaArteriolar narrowingPeripheral retinal pigmentationLoss of the foveal reflexIn advances cases Depigmented macula is surrounded by pigmented ring maculopathy - Bulls eye.Chloroquine retinopathy is dose related and usually only develops after cumulative dose of3002,Oral dose of250 mgday for 3 years significantly increases the risk of maculopathyRisk factors for chloroquine maculopathyDaily dose 3 mgkgday or 250 mgdayCumulative dose 460 gmsDuration of treatment 5 yearsEvidence of renal and hepatic insufficiency 