<prompt> Regarding termination of drug action:Drugs must be excreted from the body to terminate their actionMetabolism of drugs always abolishes their pharmacologic activityHepatic metabolism and renal excretion are the two most important mechanisms involvedDistribution of a drug out of blood stream terminates the drugs effects  <response>: - Drug action may be terminated either by liver metabolism or by renal excretion. It is not necessary to be excreted from the body.- By metabolism of the drug, most drugs will be inactivated, but some may be activated.- Some drugs give their action after distribution into the tissues. 