<prompt> Hb saturation with oxygen is mostly dependent onpO2pCO2HCO3-levelsHb  <response>: Increased pH decreased H, decreased temperature, decreased PaCO2, and decreased 2,3-DPG will increase oxygen binding to the haemoglobin Ref: Biochemistry by U. Satyanarayana 3rd edition Pgno : 198,199 