<prompt> Drug used for the chemoprophylaxis of leptospirosis is -DoxycyclineAmpicillinAmoxicillinCefotaxime  <response>: Ans. is a i.e., Doxycycline Prevention or leprospirosis No vaccine is available for human leptospirosis. Preventive strategies, including chemoprophylaxis with doxycycline, have been variably effective in different settings. Antibiotic chemoprophylaxis with Doxycycline 200 mg per oral once a week, can be considered for anticipated short-term, well-defined exposures, such as those incurred during military training or specific adventure travel with, for example, fresh-water swimming. Long-term antibiotic prophylaxis has not been shown to be effective in preventing infection in high-transmission endemic settings. General sanitation approaches e.g., rodent control and avoidance of swimming in potentially contaminated places e.g., for recreational use are recommended, but these measures are difficult to apply consistently.Treatment and Chemoprophylaxix of Leptospirosis in AdultsIndicationRegimenTreatmentMild leptospirosisDoxycycline 100mg PO bid orAmoxicillin 500mg PO tid orAmpicillin 500mg PO tidModeratesevere leptospitosisPenicillin 1.5 million units IV or IM q6h orCettriaxone 1 gd IV orCetotaxime Ig IV q6hChemoprophylaxis Doxycycline 200mg PO once a week or Azithromycin250 mgPO once or twice a weekAll regimens are given for 7 days. 