<prompt> Favourable prognosis for AML with ?t8,21Deletion 5qPreceeding MDSAge 2years  <response>: Ans. a i.e., t8,21 Monsomies eg. -5 or -7 carry poor prognosis. Prognostic factors of AML There are many prognostic factors for AML of paicular note are : - Age : - Age greater than 65 years or less than 2 years has been associated with poor prognosis independent of cytogenetics. AML evolving from prior myelodysplastic syndrome MDS is associated with poor prognosis. Leukocytosis andor an elevated peripheral blast count are associated with poor prognosis. Cytogenetics : - AML prognosis is currently separated into three broad categories based on cytogenic results:- o Favourable : inv 16, t 15:17, t 8 : 21. Intermediate : Normal, 8, 21, 22, del 7q, del 9q, Abnormal 11 q23. Unorable : - -5, -7, complexes with 5 chromosomes involved, del 5q, abnormal 3q, abnormal 17p. 