<prompt> Low Vd meansThe drug has low half lifeThe drug does not accumulate in tissuesThe drug has low bioavailabilityThe drug has weak plasma protein binding  <response>: The volume of distribution V relates the amount of drug in the body to the concentration of drug C in blood or plasmaVd amount of drug in bodyconcentration of drug CDrugs with low volumes of distribution have much lower concentrations in extravascular tissue than in the vascular compament.Katzung Pharmacology 12th edition Pg: 38 