<prompt> True about Michaelis-Guttman bodies?Calcium deposition in lysosomesLocated in inter-cellular spacesMay involve lungs and colon apart from urinary tractAll of the above  <response>: Ans. d All of the above Ref. Robbins pathology 7th 1027.MALAKOPLAKIAIt is a rare chronic inflammatory process that most often affects the bladder but can involve the GIT.It is diagnosed endoscopically, often as an incidental finding, and may appear as a mucosal plaque, a polypoid lesion, or even a stricture. Thus, it may be mistaken for a carcinoma.The diagnosis is essentially a histological one.- The characteristic lesion consists of collections of tissue macrophages which may contain inclusion bodies-- Michaelis-Guttman bodies.These are Gram-positive and thought to be glycolipid possibly breakdown products of microbes.Malakoplakia may occur with a carcinoma or secondary to malnutrition or immunosuppression. 