<prompt> Cobicistat is used along with which of the following antiretroviral drug?IndinavirDarunavirRitonavirSaquvinavir  <response>: B i.e. DarunavirRef: commediaFilespdfsmedicineshivtybosttybost_pi.pdfExplanation:CobicistatMechanism - Inhibitor of cytochrome P450 CYP 3A enzymes.Indicated as a pharmacokinetic enhancer i.e., booster of the HIV-1 protease inhibitors atazanavir and darunavir in adults.RitonavirActs as pharmacokinetic booster by inhibiting CYP3A4.Used at lower dose for this purpose.Combinations of darunavir, lopinavir, fosamprenavir, and atazanavir with ritonavir are approved for once daily administration. 