<prompt> Lysosomal Storage disorders are associated withNon-disease-specific physical findingsLoss of functionEnzyme assays not usefulGenetic testing is helpless  <response>: B Loss of function Lysosomal storage disorders LSDs are inherited diseases characterized by lysosomal storage and dysfunction. Loss of lysosomal function is associated with severe neurodegeneration, which is the prominent pathological hallmark of LSDs. Physical findings are disease-specific, and enzyme assays or genetic testing can be used to make a definitive diagnosis. 