<prompt> True about alpha-1 antitrypsin deficiency, isare -a Autosomal dominantb Pulmonary emphysemac Diastase resistant hepatic cellsd Hepatic cells are orcein stain positivee Associated with berry aneurysmbccacad  <response>: α1 -anti-trypsin deficiencyα1 -anti-trypsin deficiency, is an autosomal recessive disease marked by abnormally low levels of serum of this major protease inhibitor PiDeficiency of the enzyme leads to pulmonary emphysema panacinarLiver is characterised by :Presence of round to oval cytoplasmic globular inclusions in hepatocytes which on H and E stains acidophilic and indistinctly demarcated from surrounding cytoplasm.They are PAS positive and diastase resistantIn most part, only distinctive feature is globules infrequently-fatty change, mallory bodies.Neonatal hepatitis with cholestasisFatty change steatosisCirrhosis may develop which can transform into heptocellular carcinoma.Following information has been added in 8the of Robbins In addition, cutaneous panniculitis, arterial aneurysm, bronchiectasis and wegners granulomatosis can occur in α1- antitrypsin deficiency. 