<prompt> Most serious side effects of amphotericin B:Hepatic damageRenal damageCardiotoxicityHypochromic anemia  <response>: Ref: Sharma Sharma 3rd ed. P 783Adverse Drug reactions of Amphotericin B The most common, most serious and long term side effect of amphotericin B is Nephrotoxicity renal tubular necrosis This nephrotoxicity presents with hypokalemia, hypomagnesemia secondary to renal tubular acidosis, azotemia and even irreversible damage if the dose exceeds 5g. In order to prevent the nephrotoxicity, prior hydration with 1L of normal saline is recommended. Liposomal preparation has lesser risk of nephrotoxicity Hypochromic normocytic anemia is common and thrombocytopenia and leukopenia although less common but has been noted. Intrathecal administration: Arachnoiditis and seizure Hepatic impairment and Jaundice Infusion related toxicity chills, tachypnea, fever, vomiting, hypotension, anaphylaxis 