<prompt> A 26 years old female suffers from PPH on her second postnatal day. Her APTT is prolonged while bleeding time and prothrombin time and platelet count are normal. Likely diagnosis is:Acquired haemophilia ALupus anticoagulantDICInherited congenital hemophilia  <response>: This is a case of acquired hemophilia A. Approximately 50 percent of acquired hemophilia A patients have an underlying condition, such as an autoimmune disorder e.g., rheumatoid ahritis or systemic lupus erythematosus, malignancy, pregnancy, or a history consistent with a drug reaction. Patients with acquired hemophilia A have a prolonged aPTT caused by decreased or absent factor VIII activity in the intrinsic pathway of blood coagulation. The diagnosis of acquired hemophilia A is made by the demonstration of a solitary prolonged activated paial thromboplastin time aPTT that fails to correct on mixing with equal volumes of normal plasma 50:50 mix. The prothrombin time PT, thrombin time TT, and fibrinogen activity are all normal. Specific factor assays then are performed to determine whether a specific coagulation factor inhibitor or a lupus anticoagulant is present. Ref: Lollar P. 2010. Chapter 128. Antibody-Mediated Coagulation Factor Deficiencies. In J.T. Prchal, K. Kaushansky, M.A. Lichtman, T.J. Kipps, U. Seligsohn Eds, Williams Hematology, 8e. 