<prompt> What is the mechanism of action of Fluconazole?Inhibits fungal mitosisInhibits lanosterol 14 demethylaseInhibits squalene epoxidaseInhibit ß1,3 glucan synthase  <response>: Ref. KDT. Page. 793FluconazoleThey inhibit the fungal cytochrome P450 enzyme lanosterol 14-demethylase and thus impair ergosterol synthesis leading to a cascade of membrane abnormalities in the fungus.lower affinity for mammalian CYP450 enzymes and lesser propensity to inhibit mammalian sterol synthesis causes less side effectsIt is a water-soluble triazole having a wider range of activityIndications include cryptococcal meningitis, systemic and mucosal candidiasis in both normal and immunocompromised patients, coccidioidal meningitis and histoplasmosis 