<prompt> Which of the following metabolic abnormality is seen with long term use of loop diuretics?Metabolic acidosisMetabolic alkalosisHyperkalemiaNone of the above  <response>: By inhibiting salt reabsorption in the TAL, loop diuretics increase delivery to the collecting duct. Increased delivery leads to increased secretion of K and H by the duct, causing hypokalemic metabolic alkalosis. This toxicity is a function of the magnitude of the diuresis and can be reversed by K replacement and correction of hypovolemia. Ref: Katzung, 11th edition, Chapter 15. 