<prompt> In apoptosis, the nucleus is destroyed byEndonuclease fragmentationKaryolysisPhagocytosisNecrosis  <response>: In HE-stained tissue sections, the nuclei of apoptotic cells show various stages of chromatin condensation and aggregation and, ultimately, karyorrhexis Fig. 1-21; at the molecular level this is reflected in fragmentation of DNA into nucleosome-sized pieces. Ref Robbins 9e p 18 