<prompt> True about minimal change disease is:Peak incidence is between 2-4 years of ageRenal failure is usually present in adolescentSteroids are not effective medications for treatment.It is characterized by selective proteinuria  <response>: Ans. A. Peak incidence is between 2- 4 years of ageIn minimal change nephrotic syndrome MCNS approximately 80 of total cases of nephrotic syndrome in children, the glomeruli appear normal or show a minimal increase in mesangial cells and matrix.Findings on immunofluorescence microscopy are typically negative, and electron microscopy simply reveals effacement of the epithelial cell foot processes. More than 95 of children with minimal change disease respond to corticosteroid therapy.A diagnosis other than MCNS should be considered in children 1 yr of age, with a positive family history of nephrotic syndrome, andor the presence of extrarenal findings e.g., arthritis, rash, anemia, hypertension or pulmonary edema, acute or chronic renal insufficiency, and gross hematuria. 