<prompt> A child presents with pellagra like dermatitis and aminoaciduria. Two siblings have the condition and it is absent in two sibling while it is absent in both parents. Which of the following condition is most likely?Hanups diseaseAlkaptonuriaPhenylketonuriaVon gierkes disease  <response>: Hanup disease also known as pellagra-like dermatosis and Hanup disorder is an autosomal recessivemetabolic disorder affecting the absorption of nonpolar amino acids paicularly tryptophan that can be, in turn, conveed into serotonin, melatonin, and niacin. Niacin is a precursor to nicotinamide, a necessary component of nad . Hanup disease is caused by alterations mutations in the SLC6A19 gene. Reference: GHAI Essential pediatrics, 8th edition 