<prompt> Which of the following condition causes hyperuricemia due to both increased production and decreased excretion?PRPP Synthetase over activityGlucose-6-phosphatase DeficiencyHGP deficiencyRenal failure  <response>: Von Gierke disease cause hyperuricemia by both ways: Overproduction: Glucose 6 phosphatase deficiency leads to diversion of glucose-6-phosphate to HMP shunt - ribose-5-phosphate -PRPP - nucleotide synthesis - Uric Acid. Underexcretion: Accumulated lactic acid competes with uric acid for renal excretion. 