<prompt> About Transfusion-Related Acute Lung Injury TRALI, whiat is false ?Anti-HLA antibodies are seenImplicated donors are frequently multiparous womenLeucocytes aggregate in the pulmonary vasculatureDevelops signs of non cardiogenic pulmonary edema  <response>: Transfusion-Related Acute Lung Injury TRALI is among the most common cause of transfusion related fatalities. The recipient develops symptoms of hypoxia PaO2FiO2 300 mmHg and signs of noncardiogenic pulmonary edema, including bilateral interstitial infiltrates on chest x-ray, either during or within 6 h of transfusion. Treatment issuppoive, and patients usually recover without sequelae. TRALI usually results from the transfusion of donor plasma that contains high-titer anti-HLA class II antibodies that bind recipient leukocytes. Anti-HLA class I and anti-human neutrophil antigen HNA antibodies can be involved as well. The leukocytes aggregate in the pulmonary vasculature and release mediators that increase capillary permeability. Testing the donors plasma for anti-HLA antibodies can suppo this diagnosis. The implicated donors are frequently multiparous women. The transfusion of plasma and platelets from male and nulliparous women donors reduces the risk of TRALI. Recipient factors that are associated with increased risk of TRALI include smoking, chronic alcohol use, shock, liver surgery transplantation, mechanical ventilation with 30 cm H20 pressure suppo and positive fluid balance. Ref - Harrisons 20e p814 