<prompt> Early indication of sexual maturation in females isMenarcheThelarchePubarcheGenital maturation  <response>: The onset of pubey is triggered by various genetic and environmental factors. The activation of the hypothalamic-pituitary-gonadal axis leads to the production of gonadotropins LH FSH and sex steroids estrogen testosterone. Pubey in girls stas with Breast development thelarche- 8-13yrs Appearance of public hairpubarche At last menstruation menarche- average at 12.6 yrs range 10-16 yrs Pubey in boys stas with Increase in testicular size9-14yrs Pubarche Lengthening of penis Spermarche production of sperms at 14-16 yrs Ref: Ghai, 9th edition, Chapter 5, Page 60. 