<prompt> Leptocyte in blood smears seen in?Sickle cell anemiaThalassemiaPost splenectomyUremia  <response>: Ans. b ThalassemiaRef: Robbins 9thpg 649-652Leptocytes are flattened red cells in which the volume-to- surface area ratio is decreased. Seen in iron deficiency anemia and thalassemia in which the red cells with a low mean cell hemoglobin MCH and mean cell volume MCV are unusually resistant to osmotic lysis. 