<prompt> Pathognomonic of thalassemia major :Conjugated hyperbilirubinemiaRaised HbA2Raised HbFSevere anemia  <response>: Ans. c Raised HbF. Robbin, Pathologic Basis of Diseases 5th600; 6th615THALASSEMIAA characteristic finding on Hb electrophoresis in thalassemia minor increases in HbA0, which may constitute 4 to 8 of the total Hb normal, 2.5 - 0.3.HbF levels may be normal or slightly increased.In thalassemia major HbF is markedly increased and indeed constitutes major Hb while HbA2 levels may be normal, low or high.Patients with b-thalassemia major require intensive transfusion support to survive. Patients with b-thalassemia intermedia have a somewhat milder phenotype and can survive without transfusion. The terms b-thalassemia minor and b-thalassemia trait describe asymptomatic heterozygotes for b-thalassemia. 