<prompt> Which antihypeensive is a prodrug and is conveed to its active form in brain?ClonidineMethyl dopaMinoxidilNitroprusside  <response>: Both methyldopa and minoxidil are prodrugs. Conversion of methyl dopa to a-methylnorepinephrine takes palce in the brain. Minoxidil is activated to minoxidil sulphate by phase II reaction in the periphery. 