<prompt> Burkholderia cepacia is intrinsically resistant to:DoxycyclineTMP-SMXPolymyxin BMeropenem  <response>: Burkholderia cepacia complex strains are intrinsically resistant to a wide range of antimicrobial agents including Aminoglycosides, Polymyxin, First and Second generation cephalosporins and Carboxypenicillins. TMP-SMX, Meropenem and Doxycycline are the most effective agents in vitro and may be staed as first-line agents. Burkholderia cepacia: Gram Negative, rod-shaped, motile bacteria with obligate aerobic characteristic Recognized as an antibiotic-resistant nosocomial pathogen in ICU patients Cause of the ;Cepacia syndrome; in CF patient Rapidly fatal syndrome of respiratory distress and septicemia Intrinsically Resistant B.cepacia complex strains are intrinsically resistant to a wide range of anti microbial agents Susceptible Antimicrobial agents that are effective agianst B.cepacia complex in vitro include Aminoglycosides Polymyxins Polymyxin B First and Second generation of Cephalosporins Carbocypenicillins Trimethoprim-Suplhamethoxazole Co-trimaxazole Carbapenems Meropenem Cephalosporins Third generation e.g., Ceftazidime Ureidopenicillins Fluroquinolones Doxycycline or Minocycline Chloramphenicol Ref: Harrison;s ; Ananthanarayana 10th edition156 