<prompt> Signal pathways activate transcription factors for their transpo into the nucleus by all exceptDetachment of the transcription factor from a complexing protein can unmask a nuclear localisation signalPhosphorylation of impoin protein increases its binding affinity for transcription factorsPhosphorylation of the transcription factor can increase its impoin binding affinityDephosphorylation of the transcription factor can increase its impoin binding affinity  <response>: Impoin carrier molecule is not activated Reference: Harper; 30th edition 