<prompt> Earliest symptoms showing improvement from the classical triad of Wernickes encephalopathy to thiamine therapy is:AtaxiaOphthalmoplegiaConfusionAll improve simultaneously  <response>: Wernickes encephalopathy - Long term use of alcohol lead to thiamine deficiency . Wernicke encephalopathy, caused by vitamin B1 deficiency, is not diagnosed in about 80 of cases. Classical triad Global confusion Ophthalmoplegia - mcc 6th nerve palsy Ataxias After thiamine therapy 1st one to improve is ophthalmoplegia followed by global confusion 