<prompt> Which of these is characteristic of amyloidosis?Beta pleated, metachromasis, PAS veCongophilic, beta pleated, PAS veBeta pleated, fibrillary, congophillicAlpha pleated, small fibrils  <response>: Ans. is c i.e., Beta Pleated, congophilic, fibrillary Amyloidosis o Amyloidosis refers to a variety of condition in which amyloid proteins are abnormally deposited extracellularly between the cells in various organs tissues. What is Amyloid ? o Amyloid is a protein that has an alteration in its secondary structure which impas it a paicular insoluble form, called the beta pleated sheet conformation. Chemical nature of amyloid material o Amyloid material is composed of two components ? 1 Major component 95 -- Fibril amyloid protein. 2 Minor components 5 P-component, proteoglycans and sulfated glycosaminoglycans. o Fibril amyloid protein is responsible for tissue dysfunction due to pressure effect, while P-component contributes to amyloid deposition by stabilizing fibril amyloid protein and decreasing their clearance. 