<prompt> Infliximab is directed against:Tumor necrosis factor-a TNF-aInterleukin-1 IL-1Interleukin-12 IL-12Intercellular adhesion molecule ICAM  <response>: Ans. is a i.e., Tumour necrosis factor Infliximabis a cytokine inhibitor acting against Tumour necrosis factor TNF-aInfliximab is a chimeric antibody which consists of variable region of a murine mouse antibody to TNF-a and constant Fc region of a human antibody. Uses - It is reserved for patients with severe rheumatoid arthritis who have failed to respond to adequate trials of at least two DMARDs.Crohns colitisAlso knowThe role of another cytokine inhibitor EtanerceptIt inhibits the activity of TNF-aIt is a dimeric fusion of Two TNF receptors joined to constant Fc domain of human IgG, molecule.Unlike infliximab, it is an entirely human moleculeUsesRheumatoid arthritis patients who have failed to respond to adequate trials of at least two DMARDs.Juvenile rheumatoid arthritis Psoriasis 