<prompt> The most definitive method of diagnosing pulmonary embolism is :Pulmonary aeriographyRadioisotope perfusion pulmonary scintigraphyEKGVenography  <response>: Answer is A Pulmonary aeriography: Selective pulmonary angiography is the most specific examination available for establishing the definitive diagnosis of PE.-Harriosn 16th1563 Most definitive investigation :Pulmonary angiography is an invasive procedure, and it is the most definitive procedure. It is however ceainly not the initial investigation of choice. The initial investigation of choice in a case of suspected pulmonary embolism is either a lung ventilation perfusion scan or a CT of the chest with intravenous contrast. CT scanning of the chest with intravenous contrast is the principal imaging test for diagnosis of PE. - Harrison Lung scanning VQ scan is now a second line diagnostic test for PE Most definitive specific test for PE Q Best initial imaging test for diagnosis of PEdeg Pulmonary angiographyQ CT scan with intravenous contrast Q Preferred choice, against a lung V-Q scan 