<prompt> Esophageal carcinoma is NOT predisposed by?AchalasiaSclerodermaCorrosive IntakeBarretts esophagus  <response>: Scleroderma is not a predisposing factor for carcinoma esophagus. Predisposing factors for carcinoma esophagus: For adenocarcinoma: Chronic gastric reflux Barretts esophagus For squamous cell carcinoma: Alcohol Cigarette Mucosal damage from physical agents: long term ingestion of hot liquids, lye caustic ingestion, radiation induced strictures and chronic achalasia Other ingested carcinogens: Nitrates, nitrites, nitrosamines, smoked opiates and fungal toxins in packed vegetables. Plummer-Vinson-paterson-kelly syndrome esophageal web glossitis Iron deficiency Tylosis palmaris et plantaris congenital hyperkeratosis and pitting of palms and soles Human papillomavirus Bulimia repeated microtrauma due to vomiting, may contribute to the malignant transformation of the esophageal tissue Esophageal diveicula Ref: Harrison 17e, Page 570 ; Schwaz 9e, Page 862 ; Sabiston 18e, Page 1091 