<prompt> A couple with Rh female and Rh-male went for counseling of pregnancy. What should be advised -No treatment is neededVaccine to mother on first babyVaccine to first babyVaccine to father  <response>: Ans. is a i.e.. No treatment is needed o Hemolytic disease of newborn is seen in couples when the female is Rh -ve and male is Rh ve; since the female has capacity to develop antibodies against the D antigen if fetomaternal hemorrhage takes place incase when the fetus is Rhve. o But if mother is Rh then her immune system is already tolerant to D antigen and thus even if fetomaternal hemorrhage occurs and the fetus is Rh no antibodies are developed and there is no risk for the fetus of subsequent pregnancies to develop hemolytic disease of newborn. So no treatment is required by the couple in question. 