<prompt> Hirschsprungs disease isIs inherited in an Autosomal recessive fashionIs due to unopposed parasympathetic activity in the affected segment of the bowelHas an equal incidence in girls and boysIs seen more frequently in children with Downs syndrome than in the general population  <response>: Is seen more frequently in children with Downs syndrome than in the general population. polygenic inheritance, malefemale. Increase in sympathetic activity is due to absence of parasympathetic ganglions in the plexi of Auerbach and Meissner. 