<prompt> Which of the following is required in the formation of the structure of Haemoglobin?CopperTyrosineHistidineLeucine  <response>: The Beta-chain of Hb begins with valine and histidine. Both these amino acids are impoant in the synthesis and structure of heamoglobin. Alignment according to helical designation makes homology evident: Residue F8 is the proximal heme-linked histidine, and the histidine on the distal side of the heme is E7. The iron atom is linked by a coordinate bond to the imidazole nitrogen N of histidine F8. The E7 distal histidine, on the other side of the heme plane, is not bonded to the iron atom but is very close to the ligand-binding site. Ref: Natarajan K., Townes T.M., Kutlar A. 2010. Chapter 48. Disorders of Hemoglobin Structure: Sickle Cell Anemia and Related Abnormalities. In J.T. Prchal, K. Kaushansky, M.A. Lichtman, T.J. Kipps, U. Seligsohn Eds, Williams Hematology, 8e 