<prompt> Which of the following malformation in a newborn is specific for maternal insulin dependent diabates mellitus ?Transposition of great aeriesCaudal regressionHoloprosencephalyMeningomyelocele  <response>: Caudal regression syndrome or sacral agenesis which is very rare is the congenital defect which is specific for maternal insulin dependent diabates mellitus. It is the abnormal fetal development of the lower spine--the caudal paition of the spine. Reference : page 243 Textbook of Obstetrics Sheila Balakrishnan 2nd edition 