<prompt> All of the following enzymes are regulated by calcium or calmodulin, exceptAdenylate cyclaseGlycogen synthaseGuanylyl cyclaseHexokinase  <response>: Ca2 is needed for the direct activation of enzymes such as lipase pancreatic, ATPase and succinate dehydrogenase. Calmodulin mediated action of Ca2: Calmodulin is a calcium-binding regulatory protein. Ca-calmodulin complex activates ceain enzymes e.g. adenylate cyclase, Ca2 dependent protein kinases, glycogen synthase, glycerol-3-phosphate dehydrogenase ref DM Vasudevan 8th ed page 492 box 34.2 