<prompt> A patient presents to a physician with jaundice. Physical examination reveals a nodular, enlarged liver. CT of the abdomen shows a cirrhotic liver with a large mass. CT-guided biopsy of the mass demonstrates a malignant tumor derived from hepatic parenchymal cells. Infection with which of the following viruses would most likely be directly related to the development of this tumor?Epstein-Barr virus EBVHepatitis B virus HBVHuman herpesvirus type 8 HHV 8Human papillomavirus HPV  <response>: The tumor is hepatocellular carcinoma, which usually develops in the setting of cirrhosis due to a variety of damaging agents, including hepatitis B virus HBV infection, alcohol use, and hemochromatosis. Must know: EBV is associated with Burkitts lymphoma and nasopharyngeal carcinoma. HHV 8 a member of the herpes family is associated with Kaposis sarcoma. HPV human papillomavirus is associated with cervical, penile, and anal carcinoma. Ref: Ray C.G., Ryan K.J. 2010. Chapter 13. Hepatitis Viruses. In C.G. Ray, K.J. Ryan Eds, Sherris Medical Microbiology, 5e. 