<prompt> A 21 year old male presented with sho stature lack of secondary sexual characteristics. He has been operated for brain tumor 12 years ago underwent cranial radiation. Which of the following is true regarding acquired hypopituitarism due to radiation?At a dose of 50 Gy of radiation, only 5 of patients will manifest hypopituitarism.The majority of patients who develop hypopituitarism after cranial radiation, do so within a year of treatment.Growth hormone is the most common hormonal deficiency.Older adults are at highest risk from radiation-induced hypopituitarism.  <response>: Cranial irradiation may result in long-term hypothalamic and pituitary dysfunction. At a dose of 50 Gy of radiation, up to two-thirds of patients develop hormone insufficiency The development of hypopituitarism occurs over 5-15 years after cranial radiation Growth hormone deficiency is most common, followed by gonadotropin and ACTH deficiency Children and adolescents are at highest risk from radiation-induced hypopituitarism 