<prompt> All of the following are true about pyruvate dehydrogenase deficiency, EXCEPTMutation in the E1 component of PDH is the most commonDecrease in blood lactateKetogenic diet rich in leucine is given as a treatmentRise in pyruvate  <response>: PDH complex deficiency results in : Rise in pyruvate Upregulating other reactions of pyruvate metabolism reduction to lactate by NADH-requiring LDH leading to lactic acidosis. The most common form of PDH complex deficiency is caused by mutations to E1. 