<prompt> The detection rate of Down syndrome with first-trimester screening with NT, PAPP-A, and hCG is64-7080-8494-9699  <response>: Selected Down Syndrome Screening Strategies and Their Detection Rate: Screening test Detection rate Quadruple screen 80-82 First-trimester screen NT alone 64-70 NT, hCG, PAPP-A 80-84 Integrated screening 94-96 Sequential screening Stepwise 92 Contingent 91 Cell-free DNA 91 