<prompt> 1st line treatment for smoking cessation includesNoriptylineClonidineVareniclineBuspirone  <response>: Varenicline -ALPA 4 BETA 2 paial agonist for nicotinic receptors is the new 1st line treatment for smoking dependence. Ref: Essentials of postgraduate psychiatry By JN Vyas 1st ed Pg 351 