<prompt> All are absolute contraindications for fibrinolysis exceptUpper GI bleedHistory of ischaemic stroke 6 months backSystolic BP 180 mm of Hg at presentationPregnancy  <response>: Clear contraindications to the use of fibrinolytic agents include A history of cerebrovascular haemorrhage at any timeA nonhemorrhagic stroke or other cerebrovascular events within the past year, Marked hypeension a reliably determined systolic aerial pressure 180 mmHg andor a diastolic pressure 110 mmHg at any time during the acute presentation,Suspicion of aoic dissection, and Active internal bleeding excluding mensesRelative contraindications to fibrinolytic therapy, which require assessment of the risk-to-benefit ratio, include Current use of anticoagulants international normalized ratio 2, A recent 2 weeks invasive or surgical procedure or prolonged 10 min cardiopulmonary resuscitation, Known bleeding diathesisPregnancyA hemorrhagic ophthalmic condition e.g., hemorrhagic diabetic retinopathy,Active peptic ulcer disease, and A history of severe hypeension that is currently adequately controlled. Because of the risk of an allergic reaction, patients should not receive streptokinase if that agent had been received within the preceding 5 days to 2 years.Ref: Harrison 19e pg: 1605 