<prompt> Which of the following drugs is a direct inhibitor of clotting factor Xa?ApixabanArgatrobanFondaparinuxAspirin  <response>: All the drugs ending with XA BAN are direct Xa inhibitor XaBlocker Impoant ones are :- 1 Rivaroxaban 2 Apixaban 3 Edoxaban 4 Betrixaban b Argatroban - Direct thrombin inhibitors. synthetic non-peptide compound which binds reversibly to the catalytic site of thrombin but not to the substrate recognition siteArgatroban uses --- Tx of Thrombosis and for PCIPCI Per cutaneous Intervention in HIT patients HIT Heparin induced thrombocytopenia c Fondaparinux - Indirect thrombin inhitor. Penta-saccharidewith specitic sequence that binds to AT -III with high affinity inducing an irreversible conformational change to selectively in actively factor Xawithout binding thrombin Fondaparinux use - prophylaxis and Tx of DVT PEPulmonary Embolism as well as ACS Acute coronary syndrome dAspirin - Thromboxane synthesis inhibitor Aspirin use - CAD Coronary Aery Disease, Stroke. 