<prompt> In which of the following tumors alpha fetoprotein is elavatedChoriocarcinomaNeuroblastomaHepatocellular carcinomaSeminoma  <response>: Alpha fetoprotein AFP is a normal component of plasma protein of the human foetus secreted by yolk sac and embryonal hepatocytes which reduces 2-3 weeks after bih and persists as a low value level. Normal value is up to 10 ngml of plasma.It is an impoant tumour marker for HCC and more often HCC with cirrhosis between 100-1000 ngml. It also increases in hepatoblastoma, non-seminomatous testicular tumours and some ovarian tumoursyolk sac tumour .It also increases slightly in benign conditions of the liver only upto 100 ngml if at all. It is useful in diagnosing omphalocele, ataxia telengiectasia, neural tube defects. Reference : page 594 SRBs manual of surgery 5th edition 