<prompt> True statement regarding Barretts esophagus: September 2011Patient present with severe symptomsNormal pH profileIncreased risk of squamous cell carcinomaMetaplastic change in the lining mucosa of the esophagus  <response>: Ans. D: Metaplastic change in the lining mucosa of the esophagusBarretts esophagus is a metaplastic change in the lining mucosa of the esophagus in response to chronic gastro-esophageal refluxEsophageal cancer:Impoant predisposing factors:- Excess alcohol- Smoking- Chronic achalasia- Tylosis- Barretts esophagus- Plummer Vinson syndromeFeatures:- Progressive dysphagia MC- Weight loss- WeaknessEsophagoscopy is diagnosticChemotherapy:- Limited role- Cisplatin- Bleomycin- 5-FluorouracilMC type: Squamous cell CaMC site: Lower endMC site of adenoCa: Lower end.MC site of squamous cell Ca: Middle third 