<prompt> All of the following statements about Non Small Cell Carcinoma of Lung NSCCL are true, Except:Contralateral mediastinal nodes are a contraindication to surgical resectionSingle Agent Chemotherapy is preferred for patient 70 years with advanced diseaseSquammous Cell Carcinoma is the most common NSCCL amongst Asian populationGefitinib is most effective for female smokers with adenocarcinoma on histology  <response>: Answer is D Gefitinib is most effective for female smokers with adenocarcinoma on histology: Gefitinib is an oral small molecule Tyrosine kinase Inhibitor that inhibit signalling EGFR approved for the treatment of patients with NSCCL. Data to suppo the use of Gefitinib in NSCCL are however diminishing and Gefitinib is most effective in females who have never smoked with adenocarcinoma on histology. Single agent cgemotherapy is prefered for elderly patients 70 years American Society of Clinical Oncology ASCO recommends the use of single agent chemotherapy for elderly patients 70 years with a poor performance status 2003 Guidelines It has however now been stressed 2009 Guidelines that age alone should not be used to select chemotherapy for patients with advanced NSCLC. Physiological Age not chronological age and performance status should be considered when selecting the chemotherapy regimen. Chemotherapy for Advanced Stage IV NSCLC Young patient Good performance status PS 2 Double agent chemotherapy is preferred for first line therapy Platinum based combinations are preferred over non platinum based combinations Elderly patient Poor performance status PS 2 Single Agent Chemotherapy is preferred to reduce potential toxicity from chemotherapeutic agents. Vinorelbine or docetexal are often used for single agent chemotherapy in the elderly with a poor PS. Gefitinib is most effective for females with adenocarcinoma histology who have never smoked Gefitinib is an acceptable second line agent for treatment of patients with advanced NSCLC with adequate performance status when the disease has progressed during or after first line platinum based chemotherapy. Clinical Features that correlate with responsiveness to Gefitinib Harrison Female Sex Never smoking status Adenocarcinoma Histology Asian Ethinicity Contralateral Mediastinal nodes are a contraindication to Surgical Resection ALB. In otherwise fit individual, direct extension of tumour into the chest wall, diaphragm, mediastinal pleura or pericardium or to within 2 cm of the main carina does not exclude surgery. Though surgically resectable, patients with N2 ipsilateral mediastinal nodes may require neoadjuvant or adjuvant therapy. Contraindication to surgical resection in NSCLC Davidson Distant metastasis M1 Invasion of central mediastinal structures including hea, great vessels. trachea and oesophagus T4 Malignant pleural effusion T4 Contralateral mediastinal nodes N3 FEV, 0.8L Severe or unstable cardiac or other medical condition Squammous Cell Carcinoma is the most common histological subtype of Lung Cancer in Asia Including India Most common lung cancer worldwide is adenocarcinoma Most common lung cancer in India Asia is squammous cell carcinoma Most common lung cancer in women is adenocarcinoma Most common lung cancer in smokers is squammous cell carcinoma Most common lung cancer in nonsmokers is adenocarcinoma Most common lung cancer in young patients is adenocarcinoma Most common lung cancer to metastasize is small cell carcinoma 