<prompt> All are true about Wilsons disease exceptIncrease in liver CuIncrease in urine CuIncrease in CeruolplasminIncrease in serum Cu  <response>: Refer Robbins page no 849 Free copper dissociates and is taken up by hepatocytes. In the liver copper binds to an a2-globulin apoceruloplasmin to form ceruloplasmin, which is secreted into the blood. Excess copper is transpoed into the bile. Ceruloplasmin accounts for 90 to 95 of plasma copper. Circulating ceruloplasmin is eventually desialylated, endo- cytosed by the liver, and degraded within lysosomes, after which the released copper is excreted into bile. This degradationexcretion pathway is the primary route for copper elimination. The estimated total body copper is only 50 to 150 mg 