<prompt> About Burkitts lymphoma- What is true aEURCD34 ve surface Immuno Globulin veCD34 ve surface Immuno Globulin -yeCD34 -ye surface Immuno Globulin -yeCD34 -ye surface Immuno Globulin ve  <response>: CD34 -ye surface immunoglobulin ve Ref: Robbins ghle p. 608-6091 Burkitts lymphoma Burkitts lymphoma is a B cell lymphoma - Burkitts lymphoma is a tumour of mature B cells germinal centre tumour. Immunophenotype of Burkitts lymphoma Burkitts lymphoma is a tutnour of mature B cells. - Therefore it will express all typical markers of mature B cells such as: -- Surface immunoglobulin sIgD - CD 19 -CD 20 - CD 10 - BCL 6 However - Unlike other tumour of germinal centre origin. Burkitts lymphoma always fail to express the antiapoptotic protein BCL-2. Molecular pathogenesis of Burkitts lymphoma forms of Burkitts lymphoma are associated with translocations of c-MYC gene on chromosome 8. - The translocation paner is usually the IgH locus. - cmyc gene on chromosome 8 - IgH gene on chromosome 14 t8:14 is the most common chromosomal translocation associated with Burkitts lymphoma 80 t8:14. The other translocations associated with Burkitts lymphoma - t 2;8 Kappa light chain - t 8;22 Lambda light chain Histology of Burkitts Pymphoma It is a tumour of mature B cells. The tumour exhibits a high mitotic index and contains numerous apoptotic cells, the nuclear remnants of which are phagocytosed by interspersed benign macrophages. These phagocytes have abundant clear cytoplasm creating a characteristic Starry sky pattern. Clinical features of Burkitts lymphoma Burkitts lymphoma is of three types - Endemic - Spordic - Subset of aggressive lymphoma occurring in patients with H.I.V. Both sporadic and endemic Burkitt lymphomas are found mainly in children or young adults. Most of the Burkitts lymphoma present at extranodal sites. Endemic Burkitts lymphoma present as - Mass involving the mandible and - Shows unusual predilection. for involvement of abdominal viscera paicularly kidney ovaries, adrenal glands. Sporadic Burkitts lymphoma - It often appear as mass involving the ileocecum and peritoneium. 