<prompt> False regarding Alzheimers disease AD is:Number of senile neural plaques correlates increases with agePresence of tau protein suggest neurodegenerationNumber of neurofibrillary tangles is associated with the severity of dementiaExtracellular inclusion lesion can occur in the absence of intracellular inclusions to make pathological diagnosis of AD  <response>: Please remember that the neuropathological diagnosis of Alzheimers disease requires extensive presence of both senile plaques extra cellular deposits and neurofibrillary tangles intracellular inclusion Alzheimers disease: Pathophysiological Findings: Diffuse atrophy, Flattened Coical Sulci Dilated Cerebral ventricles Primarily involve Parietal and temporal Lobes Atrophy stas In Medical Temporal Lobe EntorhinalPerirhinal Coex Hippocampus and spreads to Lateral Medial parietal Lobes, Lateral Temporal Lobes Lateral Frontal Coex Microscopic Findings: 1 Senile plaques or Neuritic plaques or Amyloid plaques Extracellular in location Ab protein 2 Neurofibrillary Tangles: Intracellular Deposits Tau proteins Neuropathological Diagnosis of AD : Extensive presence of both Senile plaques NFT 3 Granulovacuolar Degeneration Hirano bodies Eosinophilic Inclusions - Abnormalities In Cytoplasm of Hippocampal Neurons Can be present in Elderly without dementias 