<prompt> A young male patient presents with LDL 600 mgdl, triglycerides 160 mgdl. What would be the most likely finding on physical examination?Tendon xanthomaLipemia retinalisEruptive tuberous xanthomasXanthelesma  <response>: Ans. is a i.e. Tendon xanthomas Increased LDL cholesterol and triglycerides in the normal range suggests the diagnosis of hypercholesterolemia.These disorders are characterized by mutation in the L.D.L. receptors.Most patients presents with cutaneous xanthomas on the hands, wrists, elbows, knees, heels or buttocks.Arcus cornea is present and some patients have xanthelasmas.Total cholesterol level is usually 12.93 mmolL 500 mgdl and can be 25.86 mmolL 1000 mgdl.The triglyceride level is usually normal.NoteNorma L.D.L.Desirable - 130 mgdlBorderline high - 140-160 mgdlHigh risk - 160 mgdlNormal triglyceridesDesirable - 150 mgdlBorderline high - 150-200 mgdlHigh - 200-500 mgdlThe most common physical feature to look for in these patients is tendon xanthomas.They may also show xanthelasmas but,Tendon xanthomas are pathognomonic for hypertriglyceridemia 