<prompt> Bisphosphonates are prescribed to a patient with the following adviceTake empty stomach with plenty of waterTake after mealsDiscontinue if gastritis developsDiscontinue if severe bone pain occurs  <response>: Ans. A Take empty stomach with plenty of waterRef: KDT 8th370Bisphosphonates are to be taken empty stomach in the morning with full glass of water and patient is instructed not to lie down or take food for at least 30 min. These measures are required to prevent contact of the drug with esophageal mucosa which result in esophagitis. 