<prompt> Action of i. v. thiopentone is terminated by ?Rapidly renal excretionOxidationRedistributionConjugation  <response>: Ans. is c i.e., Redistribution Three proceeses are involved in the termination of action of barbiturates: the relative impoance of each varies with the compound. Redistribution: it is impoant in the case of highly lipid soluble thiopentone. After iv injection the action of thiopentone is terminated in 6-10 mins by redistribution while the ultimate disposal occurs by metabolism tl 2 of elimination is 9 hours. Metabolism: drugs with intermediate lipid solubility sho acting barbiturates are primarily metabolized in liver by oxidation, dealkylation and conjugation. Their plasma t12 ranges from 12 - 40 hours. Excretion: barbiturates with low lipid solubility long acting agents are significantly excreted unchanged in urine. The t12 of phenobarbitone is 80-120 hours. Alkalinization of urine increases ionization and excretion. 