<prompt> Syndrome of apparent mineralocoicoid excess is due to?Increased aldosterone productionLack of inactivation of aldosteroneIncreased coisol productionLack of Inactivation of coisol to coisone  <response>: Coisol can stimulate mineralocoicoid receptors. But renal inactivation of coisol occurs to form coisone and thereby BP remains normal. SAME Syndrome of Apparent Mineralocoicoid Excess leads to lack of this inactivation. The resultant increase in coisol leads to excess activation of mineralocoicoid receptor and results in hypeension. 