<prompt> Which antidiabetic drug is used both for type I II DM -SulphonylureasMetforminAcarbosePramlinitide  <response>: Ans. is d i.e., Pramlinitide Pramlinide is the only approved drug, beside insulin, to be used in both type-I and type-2 DM. Pramilinitide This is a synthetic amylin analogue Amylin is a polypeptide produced by pancreatic 3-cells which reduces glucagon secretion from a-cells and delays gastric emptying. Pramlintide attenuates postprandial hyperglycemia and exes a centrally mediate anorectic action. It is given by subcutaneous route and is used in both Type 1 and Type 2 DM. 