<prompt> Dent disease is due to defect of?Sodium channelPotassium channelChloride channelCalcium channel  <response>: Dents disease or Dent disease is a rare X-linked recessive inherited condition that affects the proximal renal tubules of the kidney. It is one cause of Fanconi syndrome and is characterized by tubular proteinuria, excess calcium in the urine, the formation of calcium kidney stones, nephrocalcinosis, and chronic kidney failure. About 60 of patients have mutations in the CLCN5 gene Dent 1, which encodes a kidney-specific chlorideproton antipoer, and 15 of patients have mutations in the OCRL1 gene Dent 2. Dents disease often produces the following signs and symptoms: Rickets Extreme thirst combined with dehydration Nephrolithiasis kidney stones Hypercalciuria high urine calcium - 300 mgd or 4 mgkg per d with normal levels bloodserum calcium Aminoaciduria amino acids in urine Phosphaturia phosphate in urine Diagnosis is based on a genetic study of CNCL5 gene Ref: wikipedia 