<prompt> Anti-histone antibodies are diagnostic of?Drug induced LESystemic sclerosisMixed connective tissue disorderSicca syndrome  <response>: Ans is a i.e., Drug induced LE There is an extremely high frequency of antihistone antibodies drug induced LE.Generic antinuclear antibody-Most sensitive for SLEAnti ds DNA anti smith Sm-Most specific for SLEAnti histone-Drug induced lupusAnti-Ro Anti-La-Neonatal lupus with congenital heart block and sjogren syndromeAnti DNA Topoisomerase Anti Scl-70-Diffuse systemic sclerosis Diffuse sclerodermaAnti - centromere-Localized systemic sclerosis Localized scleroderma - CREST syndromeAnti Jo-1 Histidyl-t-RNA synthase-Inflammatory myopathiesAnti U1 RNP-Mixed connective tissue disease 