<prompt> BRCA1 gene is located on?Chromosome 12Chromosome 21Chromosome 17Chromosome 22  <response>: BRCA1 gene is located on the chromosome 17. Mutations in the BRCA1, BRCA2, account for 80 of cases of familial breast cancer. In addition to breast cancer, women with BRCA1 mutation have a substantially higher risk of epithelial ovarian cancers men have a slightly higher risk of prostate cancer. Likewise mutation in the BRCA2 gene increase the risk of breast cancer in both men women as well as cancer of the ovary, prostate, pancreas, bile ducts, stomach melanocytes. Ref: Robbins Basic Pathology ed 8 pg 205. 