<prompt> Which of the following indicate Ca breast -Serous dischargeRecent retraction of nippleUlceration of nippleCracked nipple  <response>: Recent retraction of the nipple may be of considerable pathological significance. A slit-like retraction of the nipple may be due to duct ectasia and chronic periductal mastitis, but circumferential retraction, with or without an underlying lump, may well indicate an underlying Ca.Although ulceration of nipple may occur in Ca breast but may occur in other conditions also.The cracked nipple may occur during lactation and be the forerunner of acute infective mastitis.Various degrees of cellular and architectural atypia Atypical hyperplasia occurs in Ca in situ and breast Ca. 