<prompt> Uveoscleral outflow is increased by -TimololBimatoprostMannitolDorzolamide  <response>: Ans. is b i.e., Bimatoprost Mechanism of action of pharmacological agents in POAGAgentMechanism of actiono b-blocker Timolol, Betaxolol, levobunolol, carteololo Prostaglandins latanoprost, bimatoprost, travoprosto Alpha agonists Non-selective Epinephrine, Dipivefrine Selective a-2 Aproclonidine, Brimonidineo Carbonic anhydrase inhibitors Dorzolamide, Brinzolamide, Acetazolamideo Cholinomimetics Pilocarpine, physostigmine, carbachol, echothiphateo Hyperosmotic agents Mannitol, glycerolo Decreased aqueous secretion from ciliary epitheliumo Increased uveoscleral aqueous outflowIncreased uveoscleral aqueous outflowDecreased aqueous secretiono Decreased aqueous secretion due to lack of HCO3-o Increased aqueous outflow due to opening of trabecular meshwork due to ciliary muscle contractiono Reduce vitreous volume and deepen anterior chamber 