<prompt> Which of the following is a Type 2 Hypersensitivity reaction?Chronic Kidney Rejection episodeAutoimmune Hemolytic anaemiaArthus reactionMitsuda reaction  <response>: Ref: Robbins E-Book, P 135 Choice A is type of type 4 Hypersensitivity reaction. Choice C is type of type 3 Hypersensitivity reaction. Choice D is type of type 4 Hypersensitivity reaction.Examples of type ii hypersensitivityDiseaseTarget antigenMechanism of diseaseClinicopathologic ManifestationsAutoimmune hemolytic anemiaErythrocyte membrane proteins Rh blood group antigens, I antigenOpsonization And phagocytosis of erythrocytes, complement mediated lysisHemalysis, anemiaAutoimmune thrombocytopenic purpuraPlatelet membrane proteins gplib-Illa integrinOpsonization And phagocytosis of plateletsBleedingPemphigus vulgarisProteins in intercellular junctions of epidermal cells desmogleinAntibody mediated activation of proteases, disruption of intercellular adhesionsSkin vesicles bullaeVasculitis caused by ANCANeutrophil granule proteins, presumably released from activated neutrophilsNeutrophil degranulation and inflammationVasculitisGoodpasteres syndromeNon- ecellagerous NCl protein of basement membrane in glomeruli and lungComplement and Fc receptor mediated inflammationNephritis, lung hemorrhageAcute rheumatic feverStreptococcal cell wall antigen; antibody cross reacts with myocardial antigenInflammation, macrophage activationMyocarditis, arthritisMyasthenia gravisAcetylcholine receptorAntibody inhibits acetylcholine binding and down regulates the receptors.Muscle weakness, paralysisGraves disease hyperthyroidismTSH receptorAntibody mediated stimulation of TSH receptorsHyperthyroidismPernicious anemiaIntrinsic factor of gastric parietal cellsNeutralization of intrinsic factor, decreased absorption of vitamin B12 Abnormal erythropoiesis, anemia 