<prompt> All are true about acetaminophen except:It is the most commonly used analgesicAbout 95 of acetaminophen undergoes detoxification by CYP2E1In severe doses liver failure may occurInjury to liver is produced by NAPQI  <response>: At therapeutic doses, about 95 of acetaminophen undergoes detoxification in the liver by phase II enzymes and is excreted in the urine as glucuronate or sulfate conjugates The injury produced by NAPQI N-acetyl-benzoquinoneimine involves two mechanisms: Covalent binding to hepatic proteins-Damage to cellular membranes and mitochondrial dysfunction, Depletion of glutathione, making hepatocytes more susceptible to reactive oxygen species-induced injury 