<prompt> Which of the following is not a feature of Minimal change disease?HypertensionEdemaProteinuriaResponsive to steroid therapy  <response>: Ans. is a i.e., Hypertension Minimal change disease lipoid nephrosis Minimal Change Disease is the most common cause of Nephrotic syndrome in children. Edema and Selective proteinuria are features of nephrotic syndrome. Fever may be present on account of increased susceptibility to infection. Minimal change disease prsents with insidious onset of nephrotic syndrome in children below 6 years of age. Hypertension is not a feature of nephrotic syndrome and is rare in Minimal change disease. Hematuria a finding of nephritic syndrome is also rare. Pathological findings include :1. Light microscopy - No abnormality2. Electron microscopy - Obliteration loss and fusion of foot processes of epithelial cells.3. Immunofluorescence - No deposits of immune reactants4. Serum complements - Normal levels Urine shows lipid cast, hyaline cast, no RBC or WBC. Minimal change disease has very good prognosis with excellent response to steroids. 