<prompt> Central dot is seen inPrimary sclerosing cholangitisLiver hamaomaCarolis diseasePolycystic liver disease  <response>: Carolis disease Clinical features Symptoms include cholangitis 64, poal hypeension 22, and abdominal pain 18 More common in males Septa containing poal veins protrude into the lumen of the ecstatic bile ducts central dot sign The main and often the only symptom of bacterial cholangitis secondary to carolis disease is fever without abdominal pain and jaundice Frequent episodes of cholangitis indicates poor prognosis Most stones are pigmented in carolis disease Ref: Sabiston 20th edition Pgno :1511 