<prompt> Which of the following statements about Fluconazole is most accurateIt is it effective in the treatment of AspergillosisIt does not penetrate the blood brain barrierIts oral bioavailability is less than that of ketoconazoleIt inhibits demethylation of lanosterol  <response>: Ref-KDT 6e p761 Azoles act by inhibiting the enzyme lanosterol-14-alpha-demethvlase.resulting in reduced ergosterol synthesis. It has very good CNS penetration and oral bioavailability. It is not very effective against aspergillosis voriconazole is thedrug of choice. 