<prompt> Which of the following mutations in a tumor suppressor agent causes breast carcinomaP43P53P73P83  <response>: Ref Robbins 9e p294 Mutation in p53 tumor suppressor gene is strongly associated with breast cancer,as well as many other sarcomas and carcinomas .this condition is called li Fraumeni syndrome Li-Fraumeni syndrome is a rare, autosomal dominant, hereditary disorder that pre-disposes carriers to cancer development This syndrome is also known as the sarcoma, breast, leukaemia and adrenal gland SBLA syndrome. The syndrome is linked to germline mutations of the p53 tumor suppressor gene, which encodes a transcription factor p53 that normally regulates the cell cycle and prevents genomic mutations. The mutations can be inherited, or can arise from mutations early in embryogenesis, or in one of the parents germ cells 