<prompt> Which diuretic could be considered appropriate for combining with ACE inhibitors -SpironolactoneEplerenoneHydrochlorothiazideAmiloride  <response>: Ans. is c i.e., Hydrochlorothiazide ACE inhibitor and diuretics o ACE inhibitors cause hyperkalemia, therefore they can be combined with furosemide or thiazide diuretics which cause hypokalemia and nullify the hyperkalemic effect of ACE inhibitors. o On the other hand potassium sparing diuretics spironolactone, eplerenone, ami 1 oridc, triamterene are contraindicated as they cause hyperkalemia and aggrevate the hyperkalemia caused by ACE inhibitors. 