<prompt> Wilsons disease is diagnosed by?Increased serum ceruloplasminDecreased liver copperIncreased urinary copper excretionDecreased urine copper excretion  <response>: ANSWER: C Increased urinary copper excretionREF: Harrisons Internal Medicine 17th ed Chapter 354. Wilson Disease Useful Tests for Wilson DiseaseTestUsefulnessNormal ValueIn Heterozygous CarriersIn Wilson DiseaseSerumceruloplasmin180-350 mgLLow in 20Low in 90KF ringsAbsentAbsentPresent in 99 if neurologic or psychiatric symptoms present.Present in 30-50 in hepatic presentation and presymptomatic state24-h urine Cu0.3-0.8 mol 20-50 gNormal to 1.3 mol 80 g1.6 mol 100 g in symptomatic patients 0.9 to 1.6 mol 60 to 100 g in presymptomatic patientsLiver Cu0.3-0.8 molg 20-50 g tissueNormal to 2.0 mol 125 g3.1 mol 200 g obstructive liver disease can cause false-positive resultsHaplotypeanalysisSiblings only0 Matches1 Match2 Matches 