<prompt> Most common Enzyme Deficiency leading to childhood hypeension is17- Alpha hydroxylase21- Beta hydroxylase11- Beta hydroxylase3- Beta hydroxy steroid dehydrogenase  <response>: Most common enzyme deficiency causing hypeension in pediatric child group is APPARENTMINERALOCOICOID EXCESS. Apparent mineralocoicoid excess AME is an autosomal recessive disorder caused by deficiency of 11 beta hydroxysteroid dehydrogenase 2 11-beta HSD 2 enzyme which is encoded by a gene in chromosome 16q22. Congenital adrenal hyperplasia due to 11b-hydroxylase deficiency is a form of congenital adrenal hyperplasia CAH which produces a higher than normal amount of androgen,resulting from a defect in the gene encoding the enzyme steroid 11b-hydroxylase 11b-OH which mediates the final step of coisol synthesis in the adrenal. 11b-OH CAH results in hypeension due to excessive mineralocoicoid effects. It also causes excessive androgen production both before and after bih and can virilize a genetically female fetus or a child of either sex. Reference: GHAI Essential pediatrics, 8th edition 