<prompt> Gene instability associated with malignancy is seen in -Klippel fiel syndromeAtaxia telangiectasiaMarfang syndromeEDS  <response>: Ans. is b i.e., Ataxia telangiectasiaSyndromes of defective DNA repair have such a high level of chromosomal instability that they are known as chromosome-breakage syndromes or chromosomal instability syndromes. 