<prompt> BCRABL gene mutation is seen in?ACMLBAMLCCLLDALLBCAD  <response>: Chronic Myeloid leukemia o Chronic myeloid leukemia is a stem cell disease that is characterized by leucocytosis with granulocyc immaturies, basophilia,splenomegaly and disnct chromosomal abnormality - Philadelphia Ph chromosome. It is one of the chronic myeloproliferave disorders.Pathogenesis of chronic mveloid leukemia o CML is an acquired disease of haemopoiec stem cell and Ph chromosome is demonstrable in erythroid,myeloid and megakaryocyc precursors. Philadelphia chromosome BCR-ABL fusion gene Philadelphia chromosome is formed as a result of reciprocal translocaonbetween long arm of chromosome 22 and chromosome 9 i.e. 9:22 ABL proto-oncogene from chromosome 9 is translocated to chromosome 22 where BCRis present and results in formaon of BCR-ABL fusion chimeric gene BCR ABL gene is hallmark of CML. 