<prompt> Protein that precipitates on heating to 45 C and redissolves on boiling isBence Jones ProteinGamma globulinAlbuminMyosin  <response>: Bence-Jones; Protein An abnormal protein occurs in blood and urine of people suffering from a disease called multiple myeloma a plasma cell tumour. Defined as monoclonal light chains present in the urine of patients with paraproteinaemic states. Either monoclonal k; or l; light chains are excreted in significant amounts in about 50 percent cases of multiple myeloma. It has a molecular weight 45000 and has sedimentation coefficient of 3.5 S. Sometimes the chains excreted may be a dimer; of L-chains. Identification--Heat Test The protein is identified easily in urine by a simple Heat Test. On heating the urine 50 to 60oC, Bence-Jones; proteins are precipitated, but when heated fuher it dissolves again. Reverse occurs upon cooling. Best detected by zone electrophoresis and immunoelectrophoresis of concentrated urineRef: Textbook of medical biochemistry, MN Chatterji, 8th edition, page no: 104 