<prompt> In acute hepatitis B, all are raised exceptHBsAgIgM anti-HbCAnti HBsAbTotal anti-HbC  <response>: Anti-HBc total antibodies all classes of antibodies, ie IgG IgM also increaseThe serological pattern of Hepatitis B virus:HBe Antigen positive chronic hepatitisHBe Antigen negative chronic hepatitis Replicative phase Non replicative phase HBV DNA HBeAg Intrahepatocyte HBcAg DNA polymerase HBV DNA very low HBeAg very low Intrahepatocyte HBcAg --Anti HBe HBV DNA HBeAg --DNA polymerase Hepatitis B patternSerological markersAcute Hepatitis BIg M Anti HBcAg ; HBsAg Chronic Hepatitis B Ig G Anti HBcAg ; HBsAg Marker of vaccination Anti HBsAg Marker of remote infection Ig G Anti HBcMarker of infectivity HBeAg Ref: Ananthanarayan 9th edition, p546-548 