<prompt> Not true about thalidomide:Causes phocomeliaNot tested in pregnant animals before introductionStill has restricted clinical useHas no antiangiogenesis action against tumour  <response>: Ans. D Has no antiangiogenesis action against tumourRef: KDT 6e p84, 834Thalidomide was banned in 1960 because of its teratogenic effect of phocomelia seal like limbs. It has anxiolytic, adjuvant analgesicantipyretic properties and has been found to counteract cancer associated cachexia.Its mechanism of action is by suppressing TNF and or by modulating IL-2.Recently it has been reintroduced as antineoplastic drug due to its anti-angiogenesis action. 