<prompt> Superior orbital fissure syndrome involves which of the following cranial nerves?II, III, IV, V and VIIll, IV, and first division of V and VIVII and VIIIIX, X and XI  <response>: Ans. b III, IV, and first division of V and VI Ref: Harrison 18thJCh. 26Major Openings of the Skull BaseApertureContentsCribriform plateOlfactory nerves, ethmoid arteriesOptic canalOptic nerve-sheath complex; Ophthalmic arterySuperior orbital fissureCranial nerves III, IV, VI and VI ophthalmic nerve, Superior ophthalmic veinForamen ovaleV3 mandibular nerveForamen rotundumV2 maxillary nerveForamen spinosumMiddle meningeal arteryVidian canalVidian artery, Vidian nerveCarotid canalInternal carotid arterySympathetic plexusJugular foramen, pars nervosa; CN IX and inferior petrosal sinusJugular foramen, pars vascularisInternal jugular vein; CN X and XIStylomastoid foramenCN VIIHypoglossal canalCN XIISupraorbital Fissure:Structures that pass through it: Lacrimal nerve Frontal nerve Trochlear nerve Superior branch of oculomotor nerve Nasociliary nerve Inferior branch of oculomotor nerve Abducent nerve Ophthalmic veins Sympathetic nerves Cavernous Sinus content and veins drain with Rule of 3 3 Afferent veins: Sphenoparietal sinus Vault veins, Supf Middle cerebral Vein Brain, Ophthalmic vein 3 Efferent Veins: Superior petrosal sinus, Inferior Petrosal Sinus, Communicating vein to pterygoid plexus 3 Contents; Cranial Nerves III, IV, V1, V2 VI 3 Areas Drain into it: Vault Bones, Brain Cerebral Hemisphere, Orbit 3 Nerves: Motor III, IV,VI,Sensory V1,V2, Sympathetic 