<prompt> In Wilms tumor the following leads to emergence of resistance to chemotherapy:Nephrogenic restsMonophasic morphologyAnaplasiaCapsular infiltration  <response>: Wilms tumor : 5 of tumors reveal anaplasia- Large, hyperchromatic, pleomorphic nuclei and abnormal mitoses . The presence of anaplasia correlates with underlying p53 mutation -Emergence of resistance to chemotherapy. 