<prompt> Keratoconj u ncti vitis sicca is -Sjogrens syndromeSLEDermatomyositisRA  <response>: Ans. is a i.e., Sjogrens syndrome Sjogrens syndromeo It is an autoimmune chronic inflammatory disease with multi-system involvement.o It typically occurs in women between 40 and 50 years of age.o Its main feature is an aqueous deficiency dry eye - the keratoconjunctivitis sicca KCS.o In primary Sogneni syndrome patients present with sicca complex - a combination of KCS and xerostomia dryness of mouth.o In secondary Sjogren s syndrome dry eye andor dry mouth are associated with an autoimmune diseae, commonly rheumatoid arthritis.o Its pathological features include focal accumulation and infiltration by lymphocytes and plasma cells with destructin of lacrimal and salivary glandular tissue. 