<prompt> Bullous disease in which autoantibodies are formed against antigens of epidermal intercellular junctionsPemphigus VulgarisEpidermolysis bullosaDermatitis herpatitisBullous pemphigoid  <response>: Bulla development in pemphigus vulgaris is due to Acantholysis, this is disruption of intercellular attachment leading to intraepidermal bullae. Autoantibodies against desmosomal protein-desmoglein-3 mediate the pathogeneis. 