<prompt> A 12 year old girl with the mood and emotional liability has a golden brown discoloration in descement membrane. Most likely diagnosis is ?Fabrys diseaseWilsons diseaseGlycogen storage diseaseAcute rheumatic fever  <response>: Ans. is b i.e., Wilsons disease Emotional liability, tremors Neurological symptoms with brown discoloration of descemets membrane of coenea suggest the diagnosis of Wilsons disease. Wilsons disease ? o It occurs due to reduced mobilization of copper from lysosomes in liver cells for excretion into the bile. o Abnormal gene for Wilsons disease is on long arm of chromosome 13 AR. Clinical features ? o Younger patient likely to develop hepatic involvement. o Later on Neurologic manifestation like tremor, dystonia, behavioral changes also develops. o K-F rings may be absent in young patients with liver diseases but are always present in patient with neurologic symptoms. o Hemolysis may be an initial manifestation. Sensory changes never occur. Diagnosis ? o Decrease ceruloplasmin level o Liver biopsy 