<prompt> All are alkylating agents except:CyclophosphamideLomustineBusulfanZalcitabine  <response>: ANTICANCER DRUGS: CLASSI FICATION A. Drugs acting directly on cells Cytotoxic drugs 1. Alkylating agents Nitrogen mustards: Mechlorethamine Mustine HCl Cyclophosphamide, Ifosfamide, Chlorambucil, Melphalan Ethylenimine : Thio-TEPA Alkyl sulfonate : Busulfan Nitrosoureas :Carmustine BCNU, Lomustine CCNU Triazine :Dacarbazine OTIC 2. Antimetabolites Folate antagonist:Methotrexate Mtx Purine antagonist:6-Mercaptopurine 6-MP, 6-Thioguanine 6-TG, Azathioprine, Fludarabine Pyrimidine antagonist:5-Fluorouracil 5-FU, Cytarabine cytosine arabinoside 3. Vinca alkaloids:Vincristine Oncovin, Vinblastine 4. Taxanes :Paclitaxel, Docetaxel 5. Epipodophyllotoxins:Etoposide 6. Camptothecin analogues:Topotecan, Irinotecan 7. Antibiotics: Actinomycin D Dactinomycin Doxorubicin Daunorubicin Rubidomycin Mitoxantrone Bleomycins, Mitomycin C 8. Miscellaneous:Hydroxyurea, Procarbazine, L-Asparaginase, Cisplatin Carboplatin Imatinib B. Drugs altering hormonal milieu 1 . Glucocoicoids: Prednisolone and others 2. Estrogens: Fosfestrol,Ethinylestradiol 3. Selective estrogen receptor modulators : Tamoxifen, Toremifene 4.Selective estrogen receptor down regulators: Fulvestrant 5. Aromatase inhibitors: Letrozole, Anastrozole,Exemestane 6. Antiandrogen: Flutamide,Bicalutamide 7. 5-alpha reductase inhibitor: Finasteride,Dutasteride 8. GnRH analogues: Nafarelin,Triptorelin 9. Progestins: Hydroxyprogesterone acetate, etc. ESSENTIALS OF MEDICAL PHARMACOLOGY K.D.TRIPATHI SIXTH EDITION PAGE NO:819,820 