<prompt> A person is diagnosed to have familial type IIa hyperlipoproteinemia. What is the basic defect in this type of hyperlipoproteinemia?Lipoprotein lipase deficiencyDefective LDL receptorAbnormal activity of Apo EOverproduction of LDL  <response>: Familial type IIa hypercholesterolemia is associated with a defect in the LDL receptor or with a mutation in ligand region of apo B-100. These patients have elevated levels of cholesterol and LDL which in turn result in atherosclerosis and coronary hea disease. Type I hyperlipoproteinemias is associated with lipoprotein lipase deficiency or apo C II deficiency causing inactive LPL. Type III hyperlipoproteinemias is due to abnormality in apo E. Type IV hyperlipoproteinemias is due to overproduction of VLDL. Ref: Botham K.M., Mayes P.A. 2011. Chapter 26. Cholesterol Synthesis, Transpo, Excretion. In D.A. Bender, K.M. Botham, P.A. Weil, P.J. Kennelly, R.K. Murray, V.W. Rodwell Eds, Harpers Illustrated Biochemistry, 29e. 