<prompt> DNA supercoiling is done byDNA polymerase IDNA polymerase IIDNA polymerase IIIDNA topoisomerase  <response>: Enzymes that catalyze topologic changes of DNA are called topoisomerases. Topoisomerases can relax or inse supercoils, using ATP as an energy source. DNA gyrase is a type of topoisomerase Harper30e pg: 362 