<prompt> If rate of elimination is directly proportion to plasma concentration the order of kinetics is -ZeroPseudo-zeroFirstSecond  <response>: Ans. is c i.e., First o The rate at which elimination take place is subjected to important influences that are referred to as order of kineticso There are two orders of such elimination.1. First order kinetic Linear kinetics2. Second order kinetic Non-linear kineticso Order of kinetic depends on the following formula.Rate of elimination a Plasma concentrationordero So, in zero order kineticRate of elimination a Plasma Cone0, i.e. 1. That means rate of elimination is constant. Constant amount of drug is eliminated per unit time. Elimination is independent of plasma concentration. As plasma cone, increases clearance decrease because elimination is constant CL Rate of elimination Plasma Cone.. Half life increase - As the concentration increases, clearance decreases so time required to reduce the plasma concentration to half will increase.o In first order kineticRate of elimination a Plasma Cone That means rate of elimination is proportional to plasma concentration. Constant fraction of drug is eliminated per unit time. Clearance remains constant because, as the plasma concentration increases, rate of elimination increases proportionately CL rate of elimination Plasma Cone. Half life remains constant because time required to reduce the plasma concentration to half, is same rate of elimination changes proportionately with plasma concentration.o The drugs whose kinetics changes from first order to zero order at therapeutic concentration are said to follow pseudo - zero order kinetics or mixed order kinetics or saturation kinetics.o Drugs showing zeropseudo-zero order kinetics: Phenytoin Tolbutamide Theophylline Warfarin Alcohol Salicylates Aspirin 