<prompt> Gum hyperplasia is seen with: March 2009AMLCMLALLCLL  <response>: Ans. A: AML Gingival hyperplasia is secondary to infiltration of the gingival tissue with leukemia cells. Gingival hyperplasia was observed in acute myelogenous leukemia AML with a frequency of 3 to 5. Gingival hyperplasia is most commonly seen with the AML subtypes acute monocytic leukemia M5, acute myelomonocytic leukemia M4, and acute myelocytic leukemia M1, M2. Tumors with monocytic differentiation often infiltrate the skin leukemia cutis and gingiva; this probably reflects the normal tendency of the monocytes to extravasate into tissues. 