<prompt> All are true about Gap junction except:Permits amino acids upto 1000 Da mol wt.Opening of gap junction does not depend on trans membrane voltageHalothane closes gap junction reversiblyGap junction is made up of connexon is made ut of six identical connexins  <response>: Ans: B Opening of gap junction does not depend on trans membrane voltage Ref:Pal GK, Functional Organization of Cell, In:Textbook of Medical Physiology, 2nd ed. Ahuja Publishing House, 2011; 3: 19Pollard TD, Earns haw EC, Intercellular Junctions. In: Cell Biology, 2nd ed. 37 : 573-79Explanation:Gap Junctions - NexusMade up of connexons - trans-membrane proteinEach connexon is made up of six identical connexins proteinAllow upto 1 KDa molecules Eg:Ions Electrical synapse2nd messengersPeptidesOpening depends onTrans mb voltH, Ca ionProtein kinaseEg. Skin, GIT. Heart. Skeletal muscle. Glial cellOleamide, a fatty acid amide produced by the brain, blocks gap junctional communication and induces sleepOrganic alcohols heptanol and octanol and general anesthetics ihalothane can also close gap junction channels reversibly: also nonspecificSigns and Symptoms for Different Classes of Shock Class IClass IIClass IIIClass IVBlood loss mLUpto 750750-1,5001,500-2,0002.000Blood loss blood volumeUpto 15!5-3030-4040Pulse rale100100120140Blood pressure mm HgNormalNormalDecreasedDecreasedPulse pressure mm HgNormal or increasedDecreasedDecreasedDecreasedUrinary output mLhr3020-305-15NegligibleCNSMental StatusSlightly anxiousMildly anxiousAnxious and confusedConfused and lethargicMutations in Connexin Subunit HumanCx-26b2 - Dominant and recessive mutations with deafness; skin diseaseCx-30b6 - Recessive deafness; skin diseaseCx-31b3 - Recessive deafness; skin diseaseCx-32b1 - X-linked point mutations, defective myelin, peripheral nerve degeneration; deafnessCx-43a1 - DeafnessCx-50a8 - Cataracts in lens of the eye 