<prompt> What is the most common extra aicular manifestation of ankylosiing spondylitis?Anterior uveitisAoic regurgitationCataractInflammatory bowel disease  <response>: Extra aicular manifestations of ankylosing spondylitis Up to 40 of patients also have peripheral musculoskeletal lesions asymmetrical, affecting entheses of large joints, such as the hips, knees, ankles and shoulders.Fatigue is a major complaint and is common to all SpAs, but its cause is unknown. Acute anterior uveitis is the most common extra-aicular feature, which occasionally precedes joint disease Ref Davidson 23e p1030 