<prompt> Which hormone is secreted from stomach that control intake of food:OrexinInsulin like growth hormoneCholecystokininGhrelin  <response>: D i.e. Ghrelin - Ghrelin, is released by stomachs, especially during fasting and stimulates appetites orexigenic. - CCK, Peptide YYPYY secreted from entire gitract but especially from ileum colon, glucagon like peptide secreted by intestines dt presence of food and insulin produced in response to GLP are gastrointestinal hormonal factors, which suppress feeding i.e. cause satiety anorexigenic. Whereas, ghrelin another gastrointestinal hormone produced mainly by stomach is orexigenic i.e. increase appetite. - Growth hormone GH also ka somatotropic hormone or somatotropin exes much of its effects through intermediate substances called somatomedins secreted by liver and to a much less extent, other tissues. Because many effects of somatomedins on growth are similar to those of insulin, therefore somatomedins are also called insulin like growth factors IGFs. Out of 4 somatomedins isolated, the most impoant is somatomedin C or IGF-1 and pygmies of Africa Levi-Lorain dwarf have congenital inability to synthesize significant amount of IGF-1. - Orexin hypocretin producing neurons occur in hypothalamus. Orexins A and B increase feeding appetite whereas, brains from humans with narcolepsy have fewer orexin producing neurons in hypothalamus. - Cholecystokinin CCK is secreted by I cells of upper small intestine jejunum and decreases feeding antiorexigenic aorexigenic, inhibits gastric emptying, and stimulates secretion of pancreatic juice rich in enzymes, contraction of gall bladder, secretion of glucagon insulin and small intestine colonic motality. It is a gastrointestinal hormone synthesized released mainly by oxyntic cells of stomach Guyton P or D1 cells of fundus of stomach. It is also produced by the intestine epsilon cells of pancreas in small amounts. Ghrelin acts to stimulate hunger appetiteQ. So blood levels rise during fasting, peak just before eating and then fall rapidly after a meal orexigenic. In this way, it is counter pa of hormone leptin, produced by adipose tissue, which induces satiation i.e. is anti-orexigenic when present at higher levels. - Ghrelin is also produced in arcuate nucleus of hypothalamus and has marked growth hormone stimulating activity i.e. it stimulates GH secretion from anterior pituitary gland by acting directly on receptors in pituitary. - G protein coupled ghrelin receptor formerly ka growth hormone secretagogue GHS receptor is expressed in arcuate nucleus, lateral hypothalamus, vagal afferent cell bodies vagal afferent endings through out gastrointestinal tract. - It has an impoant role in neurotrophy, paicularly in hippocampus and is essential for cognitive adaptation to changing environment and process of learning. 