<prompt> Streptokinase and Urokinase are contraindicated in:Intracranial malignancyPulmonary EmbolismAV fistulaThrombophlebitis  <response>: Answer is A Intracranial malignancy Malignant Intracranial Neoplasm is an absolute contraindication for Thrombolysis Streptokinase Urokinase. Contraindications and Cautions for Fibrinolytic Use in STEMI: Absolute Contraindications Relative Contraindications Any prior intracranial hemorrhage History of chronic severe poorly controlled hypeension Known structural cerebral vascular lesion Severe uncontrolled hypeension on presentation e.g., aeriovenous malformation SBP 180 Hg or DBP 110 Hg Known malignant intracranial neoplasm History of prior ischemic stroke 3 months, dementia, or known primary or metastatic intracranial pathology not covered in contraindications Ischemic stroke within 3 months Traumatic or prolonged 10 min CPR or major surgery 3 wk Except acute inschemic stroke within 3 hr. Recent within 2-4 week internal bleeding Suspected aoic dissection Non compressible vascular punctures Active bleeding diathesis excluding menses For streptokinaseanistreplase: prior exposure 5 days ago or Significant closed head or facial trauma within 3 mo. prior allergic reaction to these agents Pregnancy Active peptic, ulcer Current use of anticoagulants the higher the INR, the higher the risk of bleeding 