<prompt> A child is brought to you with history of mental retardation. On examination you find that he also has dolichocephaly, low set ears, micrognathia, clenched hands with overlapping fingers, simian crease and rocker bottom feet. Which is the commonest cardiac lesion you would expect to find in this patient?ASDVSDPDAPulmonary stenosis  <response>: This is a case of Edwards syndrome Trisomy 18. The commonest cardiac lesion in this condition is VSD followed by PDA and ASD. Multiple valvular regurgitant lesions may also be seen in Edwards syndrome. Ref: Pediatric Clinical Methods by Meharban Singh, 3rd Edition, Page 176 