<prompt> Through which of the following does glucose mediated insulin release occur?ATP sensitive K channelscAMPCarrier mediatedReceptor phosphorylation  <response>: Glucose-mediated insulin release occurs through ATP sensitive K channels. Increased blood glucose concentration is the primary controller of insulin secretion. Inside the beta cells, glucose is conveed to glucose-6-phosphate and later ATP is generated. This ATP closes ATP sensitive potassium channels, leading to rise in K and depolarisation. This in turn causes opening of voltage gated Ca2 channels and influx of Ca. This ultimately leads to secretion of insulin exocytosis. Ref: Guyton and Hall 13th edition Pgno: 990 