<prompt> Inherited defect in the extracellular glycoprotein called fibrillin-1 results in which disease?Hereditary spherocytosisMarfan syndromeMarfan syndromeDuchenne muscular dystrophy  <response>: Robbins basic pathology 9th edition page no 220,Headingmarfans syndrome Marfan syndrome is a connective tissue disorder of autosomal dominant inheritance, the basic biochemical abnormality is a mutation affecting fibrillin. Fibrillin is encoded by FBN1gene, which maps to chromosomal locus15q21. Mutations in the FBN1gene are found in all patients with Marfan syndrome. 