<prompt> Many signaling pathways involve the generation of inositol trisphosphate IP3 and diacylglycerol DAG. These moleculesAre first messengersActivate phospholipase CAre derived from PIP2Cant activate calcium calmodulin-dependent protein kinases directly or indirectly  <response>: IP3 DAG are secondary messengers derived from PIP2 they are present in the cell membrane where IP2 crosses the cell membrane and DAG doesnot. Ref: KD Tripathi 8th ed. 