<prompt> S. aureus causes a wide variety of infections, ranging from wound infection to pneumonia. Treatment of S. aureus infection with penicillin is often complicated by theInability of penicillin to penetrate the membrane of S. aureusProduction of penicillinase by S. aureusProduction of penicillin acetylase by S. aureusLack of penicillin binding sites on S. aureus  <response>: Staphylococci are Gram-positive, non-sporeforming cocci. Clinically, their antibiotic resistance poses major problems. Many strains produce 13-lactamase penicillinase, an enzyme that destroys penicillin by opening the lactam ring. Drug resistance, mediated by plasmids, may be transferred by transduction. 