<prompt> Which of the following conditions is associated with decreased E-cadherin?Invasive lobular carcinomaFibroidDuctal carcinomaIntestinal carcinoma  <response>: Ans. is a i.e., Invasive lobular carcinoma Cadherin-1 E-cadherin is a protein that is encoded by the CDH1 gene tumor suppressor gene. Loss of E-cadherin function or expression has been implicated in cancer progression and metastasis. E-cadherin downregulation decreases the strength of cellular adhesion within a tissue, resulting in an increase in cellular motility. This in turn may allow cancer cells to cross the basement membrane and invade surrounding tissues. E-cadherin is also involved in causation of breast cancer. When compared with invasive ductal carcinoma, E-cadherin expression is markedly reduced or absent in the great majority of invasive lobular carcinomas. Inactivation of CDH1 in 56 of lobular breast carcinomas. Complete loss of E-cadherin protein expression in 84 of lobular breast carcinomas.Also know Germline mutations in CDH1 are associated with familial gastric cancers, which are usually of diffuse type. 