<prompt> Gluten sensitive enteropathy is strongly associated with:-Blood group BHLA-DQ3HLA-DR4HLA-DQ2  <response>: Gluten sensitive enteropathy CELIAC SPRUE have a definitive association with HLA DQ2 DQ8 Also associated with other immune diseases including type 1 diabetes, thyroiditis Sjogren syndrome Diagnosis of celiac sprue is done by: Multiple intestinal biopsies - Villous atrophy, crypts hyperplasia along with lymphocytic infiltration Detecting antibodies like anti-TTG antibody ; anti-endomysial antibody Skin biopsy showing destruction to dermal papillae by IgA resulting in Dermatitis herpetiformis Normal villus in the small intestine Atrophy of the villi, lengthening of the crypts, and a heavy chronic inflammatory infiltrate in the lamina propria. Dermatitis herpetiformis showing vesicles with erythema on the extensor surface of the forearm. 