<prompt> Which of the following drug is associated with the highest cardiac moality?RofecoxibNicorandilLosaanMetoprolol  <response>: Coxibs are selective cox2 inhibitors- Basically, Coxibs are NSAIDS They wont cause gastric acidity as they wont exe their effect on cox-1 but as there is an increased chance of cardiac events like hea attack due to excess thrombosis Excess thrombosis is due to decrease in PGI2 and enhanced TXA2 Ref: KD Tripathi 8th ed. 