<prompt> The chronic granulomatous disease is-A leukocyte function defectAssociated with formation of multiple granulomasA benign neoplastic processA parasitic disease  <response>: Chronic granulomatous disease CGDo It is a group of disorders of granulocyte and monocyte oxidative metabolism,o InheritanceX-linked Most commonAutosomal recessiveo Phagocytosis is normal but leucocytes do not undergo degranulation following phagocytosis,o The diminished H.CL production appears to be the major reason for the defective bactericidal defect.o Mutation in the genes for the four proteins that assemble at the plasma membrane account for all patients with CGD:Two proteins from the heterodimer cytochrome b - 558 in the plasma membrane.Two other proteins interact with cytochrome after cel! activation to form NADPH oxidase required for hydrogen peroxide production.o The bacteria involved in recurrent infections are catalase positive pyogenic pathogens such as staphylococci and coliforms. Catalase negative pathogens such as streptococci and pneumococci are handled normally.o There is excessive inflammation with granulomas formation,o CFs Suppurative lymphadenopathyGingivitisAphthous ulcerationSeborrheic dermatitisObstruction of the gastrointestinal or genitourinary tract by granulomas.Autoimmune complications:Immune thrombocytopenic purpura ITPJuvenile rheumatoid arthritis JRA.o Test for the diagnosis4. Nitroblue tetrazolium P4B T test5. Dihydrorhodamine, DHR oxidation test6. Immunoblot for NADPH oxidase components 