<prompt> Chronic kidney disease is defined as the presence of a diminished GFR for at least1month3months6months12months  <response>: Chronic kidney disease previously called chronic renal failure is defined as the presence of a diminished GFR that is persistently less than 60 mLminute1.73 m2 for at least 3 months, from any cause, andor persistent albuminuria.It may present with clinically silent decline in renal excretory function in milder forms, and in more severe cases, by prolonged symptoms and signs ofuremia. It is the end result of all chronic renal parenchymal diseases.Ref: Robbins and Cotran Pathologic Basis of Disease; 9th edition; Chapter 20; The Kidney; Page no: 898 