<prompt> True about mitochondrial inheritanceAn offspring bom to an affected male will be affectedAn offspring born to an affected female will be affectedAn offspring born to an affected female will be normalAll of the above  <response>: Ans. b An offspring bom to an affected female will be affected Ref. Nelson paediatrics, Ch. 80. p. 496Mitochondrial Inheritance An individuals mitochondrial genome is entirely derived from the mother. Sperm contain few mitochondria, most of which are shed upon fertilization. Mitochondrial disorders exhibit maternal inheritance; a woman with a mitochondrial genetic disorder will have only affected offspring of either sex, while an affected father will have no affected offspring. Common manifestations include developmental delay, seizures, cardiac dysfunction, i strength and tone, as well as hearing and vision problems. Examples include- NARP- MELAS myopathy, encephalopathy, lactic acidosis, and strokelike episodes,- MERRF myoclonic epilepsy associated with ragged red fibers,- Kearns-Sayre syndrome ophthalmoplegia, pigmentary retinopathy, and cardiomyopathy. Cells may contain a mixture of mutant and normal mitochondria, referred to as heteroplasmy. 