<prompt> Patient with pruritic lesion over Left shoulder showing cigarette paper atrophy and poikiloderma with generalized lymphadenopathy. Histopathologv exmanination of lesion shows CD4 positive sezary leutzner cells. What is the dermo- epidermal manifestation of this disease?Pautriers micro abscessPin point ulcersDischarging sinusMiliaria  <response>: Ans. is a i.e., Pautriers micro abscess o Patient with pruritic lesion over Left shoulder showing cigarette paper atrophy and poikiloderma with generalized lymphadenopathy. Histopathologv exmanination of lesion shows CD4 positive sezary leutzner cells - points to the diagnosis of Mycosis fungoides.HistplogicaLfeatures of mycpsis fungoideso Histological hallmark is the presence of sezary-Lutzner cells CD4 positive.o These sezary-Lutzner cells form band like aggregates within superficial dermis and invade epidermis as single cells and small clusters, referred to as pautrier microabscess,o There is pronounced infiltration of sezary-lutzner cells into epidermis which is referred to as epidermotropism.o In more advanced nodular stage these malignant T cells sezary cells lose their epidermotropic tendency and grow deeply into the dermis, and eventually seed lymphatics and peripheral circulation. 