<prompt> Inhalational anesthetic with highest respiratory irritation isSevofluraneHalothaneNitrous OxideDesflurane  <response>: Desflurane, a fluorinated inhalational anesthetic agent - is highly irritant on the tracheobronchial tree - making it unsuitable for use as the primary anesthetic for induction of anesthesia. Among the fluorinated inhalational anaesthetics, Desflurane and Isoflurane are respiratory irritants; Sevoflurane is devoid of tracheobronchial irritation.Ref:- Goodman Gilman Pharmacological Basis of Therapeutics 13th Ed; Pg num:- 395 