<prompt> True for lithium:-Delayed absorptionNarrow therapeutic indexProtein boundCan be given safely in renal dysfunction  <response>: LITIHIUM Well absorbed orallypeal level in 2- 3 hours Not protein bounded Handled by kidney Very narrow therapeutic index Lithium concentration for optimizing therapy - 0.5 -0.8meql - bipolar disorder - 0.8 -1.2meql - acute mania - 1.5meqdl -toxicity SE - fine tremors - CNS toxicity - coarse tremors ,ataxia , hyperflexion, mental confusion - 2meql -muscle twitching , drowsiness ,convulsions ,coma Diabetes insipidus Weight gain CI - pregnancy - congenital defect Ebstein anomaly is associated with lithium exposure USE - bipolar disorders - Acute mania 