<prompt> K secretion from the loop of Henle is decreased byFurosemideThiazideSpironolactoneAcetazolamide  <response>: Potassium-sparing diuretics act in the collecting tubule to inhibit Na reabsorption and K excretion. Spironolactone is a synthetic steroid that antagonizes aldosterone at intracellular cytoplasmic receptor sites. The spironolactone-receptor complex is inactive. That is, it prevents translocation of the receptor complex into the nucleus of the target cell and, therefore, it cannot bind to DNA. This results in a failure to produce proteins that are normally synthesized in response to aldosterone. These mediator proteins normally stimulate the NaK-exchange sites of the collecting tubule. Thus, a lack of mediator proteins prevents Na reabsorption and, therefore, K and H secretion.Ref: Lippincotts Illustrated Reviews: Pharmacology, 5th edition, Page No: 286 