<prompt> Long term adverse effect of tamoxifen isWeight gainOsteoporosisVenous thrombosisBreast cancer  <response>: TAMOXIFEN - It is SERM - Actions Bone - formation of bone; decrease risk of osteoporosis Blood - HDL Breast -Decrease risk of breast cancer Liver - clotting factor leading to thromboembolism Endometrium - risk of endometrial cancer 