<prompt> Which organelle is involved in the case of sphinghomyelin deficiency:LysosomeNucleusMitochondriaCell membrane  <response>: Ans. a LysosomeRef: Harpers Biochemistry, 30th ed. pg. 251 Sphinghomyelin is a major neural tissue component, the core structure of which is formed by ceramide. It is the only sphingholipid without sugar. The common sphinghomyelin deficiency is Neiman-Pick disease. The organelle which is involved is the lysosomes which allow accumulation of sphinghomyelin. Signs symptoms of Niemen picks: Hepatosplenomegaly, decreased appetite, unsteady gait, ataxia, slurring of speech due to accumulation of sphingholipids in neural tissue. 