<prompt> A 32 year old male is diagnosed of having acute myeloid leukemia. His total WBC count was less than normal initially. Which of the following factor has a bad prognosis in AML?Monosomies of chromosomesYoung agePatients with t15;17Low WBC count  <response>: Prognostic factors of acute myeloid leukemia AML: Advancing age is associated with a poorer prognosis, in pa because of its influence on the patients ability to survive induction therapy. The leukemic cells in elderly patients more commonly express the multidrug resistance 1 MDR1 efflux pump that conveys resistance to natural product-derived agents such as the anthracyclines. Patients with t15;17 have a very good prognosis, and those with t8;21 and inv16 a good prognosis, while those with no cytogenetic abnormality have a moderately orable outcome. Patients with a complex karyotype, t6;9, inv3, or -7 have a very poor prognosis. Among patients with hyperleukocytosis 100,000L, early central nervous system bleeding and pulmonary leukostasis contribute to poor outcome with initial therapy. Karyotypes include monosomy chromosome 5 or chromosome 7 have 78 of relapse rate. Ref: Wetzler M., Marcucci G., Bloomfield C.D. 2012. Chapter 109. Acute and Chronic Myeloid Leukemia. In D.L. Longo, A.S. Fauci, D.L. Kasper, S.L. Hauser, J.L. Jameson, J. Loscalzo Eds, Harrisons Principles of Internal Medicine, 18e. 