<prompt> Which of the following causes haemolytic anemia -Hereditary spherocytosisInfectionIron deficiencySic kle cell anemia  <response>: In heriditary spherocytosis , as the age of RBC increases they undergo loss of membrane fragments and acheive spherical shape spherocyte . spherocytes are rigid inflexible and less deformable hence they get trapped in spleen to premature destruction resulting in hemolytic anemia. Referance:Exam preparatory manual for UGs -Pathology By Ramdas Nayak Page no:264 Ref Robbins 9e pg 412 