<prompt> Bevacizumab is?Monoclonal antibody against VEGFAnti-IL-2 monoclonal antibodyMonoclonal antibody against FGFRMonoclonal antibody against EGFR  <response>: ANSWER: A Monoclonal antibody against VEGFREF: Goodman Gillmans 11th ed p. 915See APPENDIX-34 below for FDA approved monoclonal antibodies1BEVACIZUMAB: Bevadzumab AVASTIN targets the vascular-endothelial growth factor VEGF and inhibits its interaction with the VEGFR1 and VEGFR2 receptors. VEGF is an angiogenic growth factor that regulates vascular proliferation and permeability and inhibits apoptosis of new blood vessels.Use: Bevadzumab is FDA approved for metastatic colorectal cancer in combination with 5-FU. Side effects: Hypertension, pulmonary hemorrhage, gastrointestinal perforation, proteinuria, congestive heart failure. APPENDIX - 34FDA Approved Monoclonal AntibodiesAntibodyTypeTargetIndicationWhat its approved to treatAbciximabchimericInhibition of glycoprotein IlbIIIaCardiovascular diseaseAdalimumabhumanInhibition of TNF-tz signallingSeveral auto-immune disordersAlemtuzumabhumanizedCD52Chronic lymphocytic leukaemiaBasiliximabchimericIL-2Rc; receptor CD25Transplant rejectionBevacizumahhumanizedVascular endothelial growth factor VEGFColorectal cancer, Age related macular degeneration off-labelCetuximabchimericEpidermal growth factor receptorColorectal cancer, Head and neck cancerCertolizumab pegolhumanizedInhibition of TNF-cr signallingCrohns diseaseDaclizumabhumanizedIL-2Rcr receptor CD 2 5Transplant rejectionEcuiizumabhumanizedComplement system protein C5Paroxysmal nocturnal hemoglobinuriaEfalizumabhumanizedCDllaPsoriasisGemtuzumabhumanizedCD33Acute myelogenous leukaemia with calicheamicinIbritumomabtiuxetanmurineCD20Non-Hodgkin lymphoma with yttrium- 90 or indium-111InfliximabchimericInhibition of TNF-cr signallingSeveral autoimmune disordersMuromonab-CD3murineT cell CD3 ReceptorTransplant rejectionNatalizumabhumanizedAlpha-4 c4 integrin,Multiple sclerosis and Crohns diseaseOmalizumabhumanizedImmunoglobulin E IgEMainly allergy-related asthmaPalivizumabhumanizedAn epitope of the RSV F proteinRespiratory Syncytial VirusPanitumumabhumanEpidermal growth factor receptorColorectal cancerRanibizumabhumanizedVascular endothelial growth factor A VEGF-AMacular degenerationRituximabchimericCD20Non-Hodgkin lymphomaTositumomabmurineCD20Non-Hodgkin lymphomaTrastuzumabhumanizedErbB2Breast cancer 