<prompt> Which of the following is seen in Conns syndrome: September 2007Water retentionHypernatremiaHyperkalemiaEdema  <response>: Ans. B: Hypernatremia Conns syndrome is primary hyperaldosteronism due to Aldosterone producing adenoma 50 Clinical presentation Usually occurs between 30 and 60 years Conns syndrome accounts for 1 of cases of hypeension Hypeension often responds poorly to treatment Biochemically there is usually a hypokalaemic alkalosis as hypersecretion of aldosterone increases the renal distal tubular exchange of intratubular sodium for secreted potassium and hydrogenions, with progressive depletion of body potassium and development of hypokalemia Polyuria is due to impairment of urinary concentrating ability. Edema is associated mainly with secondary aldosteronism. 