<prompt> All of the following are limitations of typical tricyclic antidepressants EXCEPT:Narrow safety marginLow oral bioavailabilityFrequent side effectsLong latent period for response  <response>: Ref: KDT 6e p443, 444 TCAs have very good oral absorption These agents have narrow therapeutic index and thus low safety margin. Sedation and anticholinergic adverse effects are seen frequently with the use of TCAs. Antidepressant actions of both TCAs as well as SSRIs take several weeks to manifest. 