<prompt> A sewerage worker presents to OPD with acute febrile illness alongwith jaundice and conjunctivitis. His blood sample was taken and sent to lab . Lab findings are suggestive of kidney failure and elevated hepatic enzymes. Which of following is likely diagnosis ?MalariaLeptospirosisPeussisTyphoid  <response>: Given scenario suggests diagnosis of Weils disease Ictero-haemorrhagic disease Leptospirosis Leptospirosis - Caused by Leptospira interrogans Leptospira is an actively motile spirochete Mode of transmission: Zoonotic , by contact with water or moist soil contaminated with rats urine or dead rats. 3 R associated with leptospirosis - Rat urine , Rice Paddy field worker and Rainy water Incubation period - 5-14 days. Disseminated Leptospirosis AKA Weils disease is characterized by : High-grade fever febrile illness and conjuctivitis, jaundice and hemorrhages Ictero-hemmorhagic disease and impairment of kidney functions Lab diagnosis: a Serological tests: - MAT - 1 Microscopic agglutination test Preferred 2 Macroscopic agglutination test b PCR for Leptospira species Culture media: 1 EMJH medium 2 Koaokoff medium 3 Fletchers medium Treatment: Leptospirosis is treated with antibiotics, such as doxycycline or penicillin, which should be given early in the course of the disease. Intravenous antibiotics penicillin ceftriaxonecefotaxime may be required for persons with more severe symptoms. 