<prompt> A 78-year-old man repos anorexia, fatigue, and generally feeling unwell. On examination he has a large spleen, appears pale, and the rest of the examination is normal. His blood count is abnormal; the WBC is 46000ml with increased mature granulocytes, hemoglobin 9.0 gdL, and platelets 450,000mL. Fuher investigations reveal BCR-ABL transcripts. T315I mutation is also seen. What is the drug of choice for this condition?BosutinibPonatinibBoezomibChlorambucil  <response>: All Investigation points towards the diagnosis of CML. Management of CML: Tyrosine kinase inhibitors 1st line: Imatinib 2nd line: Dasatinib Nilotinib Bosutinib DOC for imatinib resistant CML 3rd line : Ponatinib DOC for T315I mutation DOC when there is failure of 2 TKIs Allogenic stem cell transplantation for patients who have progressed to blast cell crisis stage. 