<prompt> Leiden mutation involves:Factor VFactor VIProtein CProtein S  <response>: a. Factor VRef: Nelsons 20e p 2384-2389, Ghai 8e p 350-352Factor V Leiden: glutamine arginine substitution at amino acid residue 506 that renders factor V resistant to cleavage and inactivation by protein C also called Activated Protein C resistance 