<prompt> Hydatidiform - mole, characterized histologically byHyaline membrane degenerationHydropic degeneration of the villous stromaNon proliferation of cytotrophoblastsNon proliferation of syncytiotrophoblasts  <response>: Hydropic degeneration of the villous storma: Ref: 193-97, 201-DHYDATIDIFORM MOLE Vesicular mole - It is an abnormal condition of placenta where there are partly degenerative and partly proliferative changes in the young chorionic villi. It is best regarded as a benign neoplasm of the chorion with malignant potential Vaginal bleeding is the commonest presentation 90 white currant in red currant juice Expulsion of grape like vesicles rich in HCG per vaginum is diagnostic of vesicular mole Histology shows - hydropic degeneration of the villous stroma with absence of blood vessels and trophoblastic proliferationRISK FACTORS FOR MALIGNANT CHANGE Patient above the age of 40 irrespective of parity Patients having previous 3 or more births irrespective of age. Age is more important than the parity Initial serum hCG 100,000 mIUml Uterine size 20 weeks Previous history of molar pregnancy Large 6 cm thecaleutin cystsImportant features of complete and Partial molesFEATURESCOMPLETE CLASSIC MOLEINCOMPLETE EmbryofetusAbsentPresent Hydropic degeneration of villiPronounced and diffusedVariable and focal Trophoblast hyperplasia Uterine sizeDiffuseFocal Theca leutin cystsMore than the date 30 - 60Less than the date KaryotypeCommon 25 - 50Uncommon phCG46 XX 85 Paternal in originTriploid 90 diploid 10 Classic clinical symptomsHigh 50, 000CommonSlight elevation 50,000Rare Risk of persistent gestational trophoblastic neoplasia GTN205 