<prompt> Which of the following type of thyroid cancer metastasize to the bone MOST commonly?FollicularPapillaryHuhle cell tumorAnaplastic  <response>: Papillary cancer spreads mainly by lymphatic route. Anaplastic thyroid carcinoma by direct anaplastic cancer is characterized by extensive local invasion Follicular spreads mainly by hematogenous route to lung, bones and CNS So bone metastasis is common in follicular cancer In follicular carcinoma, huhle cell carcinoma a subtype of follicular carcinoma is more invasive and metastasize more frequently to bones. Bony metastasis from thyroid is osteolytic. Ref: Harrison 14e Page 2031. 