<prompt> HER-2 neu receptor play a role in:Predicting therapeutic responseDetermining treatment for recurrence of tumorDiagnosis of breast CaScreening of breast Ca  <response>: Ans. is a i.e., Predicting therapeutic response o Overexpression of HER-2neu in breast cancer patients is associated with poor prognosis and increases disease recurrence. o Overexpression HER-2neu also predicts good response to transtuzumab Herceptin, a drug approved for HER-2 neu overexpressing breast cancer. o Because of its prognostic role as well its ability to predict response to transtuzumab Herceptin, breast cancers are routinely checked for overexpression of HER-2neu. 