<prompt> Best screening marker of prostate cancer isa - feto proteinProstate specific antigenCA-19-20CA-125-26  <response>: B. i.e. Prostate - specific antigen 1045 - CSDT 12th Combination of digital rectal examination and serum PSA monitoring is the most effective screening protocol AFP is elevated in 70 of patients with non seminomatous testicular cancer but is not elevated in patients with seminoma AFP in - Hepatocellular CA, Gonadal germ cell tumour, cirrhosis. Hepatitis Finding of a PSA 10 nmolml is suggestive of cancer and 35 ngml is almost diagnostic of advanced prostate cancer. A decrease in PSA to the normal range following hormonal ablation is a good prognostic sign Trans rectal ultrasonogram in evaluation of carcinoma prostate most useful for - Taking guided biopsy CA of prostate arise from peripheral zone and BPH from Transition zones 