<prompt> In chronic Hepatitis B infection, which one of the following markers is indicative of active viral replication and the corresponding risk of disease transmission?Hbe antigenHBs antigenAnti - HbeAnti - HBs  <response>: HBeAg indicates active intrahepatic viral replication, reflecting high infectivity REF:p ANATHANARAYANAN MICROBIOLOGY NINTH EDITION PAGE.547 