<prompt> Most specific test for SLEss DNAds- DNAAnti- smith antibodyHistone  <response>: Ans.c Anti- smith antibodyTest Description ANA Screening test has sensitivity 95 not diagnostic without clinical features Anti-dsDNA Antibody: High specificity, sensitivity only 70 and levels are variable based on disease activity Anti-Sm antibody: Most specific antibody for SLE AntiSSA Ro or Anti-SSB La Present in 15 of patients with SLE and other connective tissue disease such as Sjogren syndrome Lupus anticoagulant Direct Russell viper venom test to screen for inhibitors in the clotting cascade in antiphospholipid antibody syndrome Direct Coombs test Anti-histone : Drug-induced lupus e.g with procainamide or hydralazine 