<prompt> Earliest sign of compartment syndrome of leg is:Skin mottlingLoss of pulseTingling numbnessPain on passive stretching of toes  <response>: Ans. D. Pain on passive stretching of toesPain out of proportion to clinical situation is usually the first symptom in compartment syndrome of leg while pain on passive stretching is most sensitive sign prior to the onset of ischemia. This is the most frequent in the lower leg. 