<prompt> Gonads to testes differentiation -SRY geneWNT-4 geneDAX1 geneNone  <response>: In normal differentation final form all sexual structures is consistent with normal sex chromosome XX for female, XY for male.46 XX chromosome with genetic factor such as DAX1 and signalling molecule WNT-4 necessary for development of ovary.Y-chromosome contains SRY gene svhich differentiate gonads to testes.Anti-mullerian hormone AMH also ka mullerian-inhibiting substance - first testicular hormone secreted at 6-7 weeks of gestation which cause mullerian duct to regress. 