<prompt> Which one has least mineralocoicoid activity?CoisolPrednisoloneFludrocoisoneMethyl prednisolone  <response>: Coisol Hydrocoisone has primary glucocoicoid action and has significant mineralocoicoid activity. Prednisolone has glucocoicoid activity but at high doses fluid retention does occur. Fludrocoisone is a potent mineralocoicoid having very less glucocoicoid activity. Methylprednisolone is more selective glucocoicoid with very less mineralocoicoid activity REF.Essential of medical pharmacology K D TRIPATHI 6 Edition - Page No - 281 