<prompt> The initiating mechanism in endotoxic shock isPeripheral vasodilationEndothelial injuryIncreased vascular permeabilityReduced cardiac output  <response>: ref Robbins 9e p131-132 The principal mechanism for septic shock includes: Peripheral vasodilation and pooling of blood Endothelial activationinjury Leukocyte induced injury Disseminated intravascular coagulation Activation of cytokine cascades 