<prompt> Which of the following is not true about PTEN gene?It is the membrane associated phosphataseEncoded by gene located on chromosome 10q23It is mutated in endometrial, breast, thyroid carcinomaIt acts as a proto-oncogene  <response>: PTEN phosphatase and tensin homologue Membrane-associated phosphatase encoded by a gene on chromosome 10q23 that is mutated in Cowden syndrome Autosomal dominant disorder CF:- Marked by frequent benign growths, such as skin appendage tumors Increased incidence of epithelial cancers, paicularly of the breast, endometrium, and thyroid. PTEN acts as a tumor suppressor by serving as a brake on the PI3KAKT arm of the receptor tyrosine kinase pathway. PTEN gene function is lost in many cancers through deletion, deleterious point mutations, or epigenetic silencing. 