<prompt> A one year old child having leukocoria was detected to be having a unilateral, large retinoblastoma filling half the globe. Current therapy would involveEnucleationChemotherapy followed by local dyesDirect Laser ablation using photodynamic cryotherapyScleral radiotherapy followed by chemotherapy.  <response>: Tumor involving less than half of the globe Multimodal therapy Chemoreduction followed by local destruction.Tumor involving half or more of the globe Enucleation. 