<prompt> What is the first line of drug for post-menopausal Osteoporosis?RaloxifeneOestrogenBisphosphonatesCombined OCPs  <response>: Treatment of post-menopausal Osteoporosis : Bisphosphonates First-line therapy. They increase bone density and reduce the risk for spine, hip and non-veebral fractures. Synthetic analogues of pyrophosphate that bind to the hydroxyapatite in bone and inhibit osteoclastic bone resorption. 