<prompt> False regarding Multiple myeloma is:It is a calcified proteinBence Jones protein in urineLytic bone lesionsRoulex formation of RBCs  <response>: Ref: Harrisons Principles of Internal Medicine, 18th editionExplanation:Multiple myelomaMultiple myeloma is a malignant proliferation of plasma cells derived from a single clone.CharacteristicsLytic hone lesionsAnemia with high ESRRoulex formation of red cellsRenal failure InfectionsHypercalcemiaTriad of Multiple myelomaMa now plasmacytos is 10Lytic bone lesionsSerum and or urine M componentMonoclonal plasma cells k, A light chain restricted in BI or as a tumor solitary plasmacytoma.End organ damage-Lytic bony lesions.Anemia.Hypercalcemia.Renal failure with paraprotenemia mostly Ig G or Iga.S.electrophoresis for M band b,g; Urine Bence Jones protein for light chainsNon secretory myeloma- no paraproteins, poor prognosisX-rays axial skeleton-skull, spine. long bones, ribs for lytic lesionsPET or MRI useful for early lesionsRadionuclide scan not usefulMust be differentiated from smoldering myeloma MG USTreatment: ThalidomideIenolidamide high dose dexamethasoneBortezomib. Autologous hematopoietic SCTLocalized RT for vertebral collapseBisphosphonates for malignant hypercalcemia beware of their osteonecrosis jaw!PrognosisStageb2 microglobulinAlbuminSurvivalStage 13.5mgL 3.5gdL5yrsStage 23.5-5.5mgL Stage 35.5mgL 2yrs 