<prompt> Treatment of choice in severe depression is -FluoxetineAlprazolamECTNone  <response>: Make it very clear in your mind that the initial treatment of choice for severe depression is antidepressant medications.ECT is the treatment of choice when severe depression is associated with a suicidal tendency or when severe depression is associated with psychotic features or when severe depression is refractory to antidepressants. 