<prompt> Burkitts lymphoma is associated with which of the following genetic abnormality-t9:22del.5qt8:14t17:15  <response>: Ans. is C i.e., t8:14 o t8:14 is the most common translocation seen in association with Burkins Lymphoma. Demonstration ofvety high proliferative fraction and the presence of the t 8:14 or one of its variants t 2:8 or t8:22 can be confirmatory of Burkiti s lymphomaleukemia Translocation in Burkitts Lymphoma Burkitt s lymphomaleukemias are associated with reciprocal translocations involving the c-myc gene on chromosome 8 Most common translocation 70cases Less common translocations t 8 : 14: c- may gene on chromosome 8 and lgH heavy chain on chromosome 14 t 8 : 22 c- myc gene on chromosome 8 and l-light chain on chromossome 22 t 2 :8: c- mye gene on chromosome 8 and l-light chain on chromosome -2 