<prompt> Therapeutic effects of clomiphene manifests as the following:Anti-gonadotrophinAnti-progesteroneAnti-oestrogenAnti-androgenic  <response>: Clomiphene citrate is a potent anti-estrogen that primarily is used for treatment of anovulation in the setting of an intact hypothalamic--pituitary axis and adequate estrogen production e.g., PCOS. By inhibiting the negative feedback effects of estrogen at hypothalamic and pituitary levels, clomiphene increases follicle-stimulating hormone FSH levels--typically by 50--and thereby enhances follicular maturation. Ref: Schimmer B.P., Parker K.L. 2011. Chapter 66. Contraception and Pharmacotherapy of Obstetrical and Gynecological Disorders. In L.L. Brunton, B.A. Chabner, B.C. Knollmann Eds, Goodman Gilmans The Pharmacological Basis of Therapeutics, 12e. 