<prompt> Defective phagolysosome is feature of?Chronic Granulomatous DiseaseChediak - Higashi - syndromeAtaxia telangiectasiaFanconi Anemia  <response>: Inherited defects in phagolysosome function. One such disorder is Chediak-Higashi syndrome, Autosomal recessive condition Defective fusion of phagosomes and lysosomes, resulting in defective phagocytes function and susceptibility to infections. The main leukocyte abnormalities are:- Neutropenia Defective degranulation Delayed microbial killing The gene associated with this disorder encodes a large cytosolic protein called LYST, which is believed to regulate lysosomal trafficking. 