<prompt> Drawback of aesunate is:Poor bioavailabilityRapid recrudescence of malariaHypoglycemiaHemolysis  <response>: Because aemisinins are sho acting drugs, monotherapy needs to be extended beyond the disappearance of the parasites to prevent recrudescence. After 5 days treatment recrudescence rate is -10, while with a 3 day course it is -50. Recrudescence can be totally prevented by combining 3 day aesunateaemether with a long acting drug ESSENTIALS OF MEDICAL PHARMACOLOGY page no. 830 