<prompt> All are TRUE about CA breast, EXCEPT -Affected sibling is a risk factorPagets disease of nipple is intraductal type of CACommon in aged nulliparousIncreased incidence with prolonged breast feeding  <response>: Ans. is d i.e., Increased incidence with prolonged breast feeding Prolonged breast feeding has a protective effect. Earlier it was controversial whether breast feeding had any beneficial effect or not. But many trials have now proved that longer durations of breast feeding have a protective effect. Ref: Robbins 8e p10777e, p 1132; Cancer of Breast by Donegan Spratt, 5e, p 117; Bailey Love 25e p837 24e, p 835; NMS 4e, p 449; Washington Manual of Surgery 4e, p 525; Schwaz 8e, p 466J Pagets disease of nipple -Pagets disease of the breast is a superficial manifestation of an underlying breast carcinoma. The underlying breast carcinoma is intraductal carcinoma. - it presents clinically as a chronic eczematous eruption of nipple, which may be subtle but may progress to an ulcerated, weeping lesion. - Pagets disease usually is associated with extensive DCIS and may be associated with an invasive cancer. The carcinoma may or may not be palpable. - Pathognomonic histological feature is presence of Pagets cells in the epithelium. Pagets cells are large pale vacuolated cells. Treatment is described ahead. 