<prompt> 40 year old patient presented with excessive skin pigmentation of face neck and extensor aspects of forearms having diabetes and ahropathy and Dyspnoea on exeion, class III. Clinical examination revealed hepatosplenomegaly and spider angioma. All are true about this condition, except:Caused by a mutant gene termed HFERisk of hepatocellular carcinoma is very highFemales are commonly affectedThe most common cardiac manifestation is CCF  <response>: The diagnosis is hemochromatosis. Major manifestations of haemocromatosis are cirrhosis, diabetes, ahritis, cardiomyopathy, hypogonadism. Males are commonly involved than females, as females have regular mentraul periods where there is a blood loss. 