<prompt> What is the drug that can be used for rheumatic fever prophylaxis in a patient with a history of allergy to Penicillin?ErythromycinStreptomycinAmoxicillinSulfasalazine  <response>: The best antibiotic for secondary prophylaxis is benzathine penicillin G 1.2 million units,or600,000units if 27kg delivered every 4weeks. It can be given every 3weeks, or even every 2weeks, to persons at, paicularly high risk. Oral penicillin V 250mg can be given twice daily instead but is less effective than benzathine penicillin G. Penicillin allergic patients can receive erythromycin 250mg twice daily.Reference: Harrison;s Principles of Internal Medicine; 19th edition; Chapter 381; Acute Rheumatic Fever 