<prompt> Which one of the following is an indication for valproate?Prophylaxis for migraineComplex partial seizuresAcute maniaAll of the above  <response>: Ans. D. All of the aboveValproic acid and its formulation derivatives divalproex sodium, extended-release ER divalproex sodium, and valproate sodium injection represent the first-generation mood stabilizing anticonvulsants.Valproate is currently approved by the U.S. Food and Drug Administration FDA for1 Monotherapy or adjunctive therapy for complex partial seizures2 Monotherapy or adjunctive therapy for simple and complex absence seizures3 Adjunctive therapy for patients with multiple seizures that include absence seizures4 Prophylaxis of migraine5 Treatment of acute manic episodes associated with bipolar disorder. 