<prompt> In the management of diabetes mellitus, lactic acidosis is commonly caused by which of the following: March 2005TolbutamideGlipizidePioglitazoneMetformin  <response>: Ans. D: Metformin Medicinal and toxic causes of lactic acidosis Acetaminophen Alcohols and glycols ethanol, ethylene glycol, methanol, propylene glycol Antiretroviral nucleoside analogs zidovudine, didanosine, lamivudine Beta-adrenergic agents epinephrine, ritodrine, terbutaline Biguanides phenformin, metformin Cocaine Cyanogenic compounds cyanide, aliphatic nitriles, nitroprusside Sugars and sugar alcohols fructose, sorbitol, and xylitol, Salicylates Strychnine Sulfasalazine Valproic acid Diethyl ether, 5-fluorouracil Halothane, propofol Isoniazid 