<prompt> Translocation of bcr-abl gene is characteristically seen in-Chronic myeloid leukemiaAcute myeloid leukemiaChronic lymphatic leukemiaAcute lymphatic leukemia  <response>: In CML BCR-ABL directs the synthesis of a constitutively active BCR-ABL tyrosine kinase , which in CML is usually 210kDa in size . In more than 90 of cases ,BCR - ABL is created by reciprocal translocation the so called Philadelphia chromosome Ref: Robbins. Pathologic basis of disease ;pg 616 