<prompt> ANA seen in SLE are directed against?mRNAdsDNANucleolusRibosomes  <response>: Ans is b i.e. dsDNA Antibodies to double - stranded DNA and the Smith Sm antigen are virtually diagnostic of SLE ---RobbinsAntinuclear antibodies in SLE1 Generic antinuclear antibodies ANA These are most common 93-100 of patients, thus are most sensitive antibodies for SLE best screening test.2 Anti-dsDNA and Anti-smith Sm antibodies These are the most specific antibodies for SLE.3 Antihistone antibodies Particularly seen in drug induced SLE.4 Anti-RNP SS-A Ro, SS-B La These are seen in neonatal lupus with congenital heart block and in subacute cutaneous lupus. These antibodies are associated with decreased risk of lupus nephritis.5 Other less common types of ANAs in SLE Anti-Ul RNP Anti-DNA topoisomerase Scl-70 Anticentromere Anti-histidyl t-RNA synthase 