<prompt> Lewis Triple Response is mediated by:HistamineAxon reflexInjury to endotheliumNone of the above  <response>: Histamine is primarily responsible for Lewis Triple Response. Ref: Goodman and Gilmans Manual of Pharmacology and Therapeutics, 11th Edition, Page 405; Skin Immune System By Jan D. Bos, Pages 401-2; Ganongs Review of Medical Physiology, 22nd Edition, Pages 593, 625, 627; Basic and Clinical Pharmacology By Katzung, 25th Edition, Page 258 