<prompt> A five-year-old boy with coarse facial features, mental retardation, dysostosis multiplex. Corneal clouding was not present. What is the diagnosis:MPS Type IVHurler diseaseHunter diseaseGauchers disease  <response>: Coarse facial features is a typical feature of Mucopolysaccharidosis MPS. Hunter disease : MPS Type II, Iduronate Sulfatase is deficient. X-linked recessive, so occurs exclusively in males. No corneal clouding. Dermatan sulphate Heparin Sulphate accumulates. Accumulation of Heparin Sulphate leads to mental retardation. Corneal clouding is present in Hurler disease so option 2 is ruled out 