<prompt> A person was on chemotherapy for 2 week for some mediastinal tumour. Now he develops high frequency hearing loss. Most probable cause of this condition is use of:CispiatinEtopositeDoxorubicinMethotrexate  <response>: Ans: A Cisplatin OTOTOXIC DRUGS P.LDhingra 6th33-34Various drugs chemical can damage the in ner ear cause sensorineural hearing loss, tinnitus sometimes vertigoCytotoxic drugs causing hearing loss are- nitrogen mustardfmechlorethamine, cisplatin carboplatinCisplatin: Important toxicities are- renal impairment emetogenic potential.Tinnitus, deafness, sensory neuropathy byperuricaemia are other problem- K.D.T 7th861Carboplatin: Nephrotoxicity, ototoxicity neurotoxicity are low as compared to cisplatin- K.D.T 7th861Table Dhingra Ototoxic drugsA. Aminoglycoside antibiotisE. AnalgesicsStreptomycinDihydrostreptomvcinGentamicinTobramycinNeomycinKanamycinAmikacinNetilmycinSisomycinSalicylatesIndomethacinPhenylbutazoneIbuprofenF. ChemicalsAlcoholTobaccoMarijuanaCarbon monoxidePoisoningB. DiureticsFurosemideEthacrynic acidBumetanideG. MiscellaneousErythromycinAmpicillinPropranololPropylthiouracilDeferoxamineC. AntimalarialsQuinineChlonoquineHydroxychloroquineD, Cytotoxic drugsNitrogen mustard MechlorethamineCisplatinCarboplatin 