<prompt> Which of the following anticoagulants doesnot require routine laboratory coagulant profile monitoring?WarfarinDabigatranArgatrobanHeparin  <response>: Dabigatran is an oral anticoagulant classified as a direct factor Xa inhibitor that does not require Coagulant profile Monitoring. When given in fixed doses, Dabigatran produces such a predictable anticoagulant response that routine coagulation monitoring is unnecessary. Heparin and Warfarin require close monitoring because of their narrow therapeutic index and increased risk for bleeding. Argatroban is a synthetic parenteral direct thrombin inhibitor that requires routine laboratory monitoring of their therapeutic effect while balancing the risk of bleeding with that of clinical efficacy. Anticoagulant Not requiring Coagulant Profile Monitoring: Parenteral Indirect Thrombin Inhibitors: Low molecule Weight Heparin LMWH Enoxaparin, Dalteparin, Nadroparin, Tinzaparin, Ceoparin, Reviparin, Ardeparin, Parnaparin and Pemiparin Indirect Factor Xa Inhibitors: Desirudin Exception Oral Direct Thrombin Inhibitors Dabigatran Direct Factor Xa Inhibitors Rivoraxaban Apixaban Betrixaban Edoxaban Japan Desirudin is a parenteral Direct thrombin Inhibitor given subcutaneously in low doses and doesnot require monitoring. Anticoagulants Requiring Caogulant Profile Monitoring: Parenteral: Parenteral Direct Thrombin Inhibitors Hirudin derivatives Lepirudin Hirudin analogues Bivarudin Argatroban Parenteral Indirect Thrombin Inhibitors Heparin Oral Coumarin derivatives Vitamin K Antagonist Warfarin Indanediones Vitamin K Antagonists Phenindone Ref: KDT 7th edition 