<prompt> Imatinib is used in the treatment of?Chronic myelomonocytic leukemiaMyelodysplastic syndromeAcuted lymphoid leukemiaGastro intestinal stromal tumors  <response>: lmatinib This novel antineoplastic drug inhibits the tyrosine protein kinases in chronic myeloid leukaemia CML cells and the ones that are activated by platelet derived growth factor PDGF receptor, stem cell receptor and c-kit receptor found in gastrointestinal stromal tumour GIST, a rare tumour. Stricking success has been obtained in chronic phase of CML as well as in accelerated phase, and in metastatic kit-positive GIST. Adverse effects are fluid retention, edema, vomiting, abdominal pain, myalgia and liver damage. ESSENTIALS OF MEDICAL PHARMACOLOGY K.D.TRIPATHI SIXTH EDITION PAGE NO:828 