<prompt> Pagets disease of the nipple isSuperficial manifestation of underlying breast CaGalactoceleEczemaAll of the above  <response>: Pagets disease of the nipple is superficial manifestation of an intraductal breast carcinoma. The malignancy spreads within the duct up to the skin of the nipple and down into the substance of the breast. It mimics eczema of nipple and areola. In Pagets disease, there is a hard nodule just underneath the areola, which later ulcerates and causes destruction of nipple. Histologically, it contains large, ovoid, clear Pagets cells with malignant features. Pagets hyperchromatic cells are located in rete pegs of epidermis containing intracellular mucopolysaccharides as clear halo in cytosol. Reference : page 533 SRBs manual of surgery 5th edition 