<prompt> Which of the following provides the best explanation for neostigmine being preferred over physostigmine for treating Myasthenia gravisIt is better absorbed orallyIt has longer duration of actionIt is the additional direct on agonistic action on nicotinic receptor in the muscle end plateIt Penetrates blood brain barrier  <response>: Ref-KDT 6e p103 Neostigmine is a quaternary ammonium derivative and is lipid insoluble. Its absorption from GIT penetration in the brain and cornea is much less than physostigmine . It produces additional action on NM receptor 