<prompt> Risk factors for Alzheimers include:-Klinefelter syndromeNoonam syndromeDowns syndromeTurner syndrome  <response>: Alzheimer disease is associated with deposition of amyloid betaAB plaque which is produce from amyloid associated proteinAPP which is coded from gene present on chromosome 21. This is called pre senile dementia or premature Alzheimer. Noonan syndrome : defect in gene PTPN11, KRAS, SOS1 leading to defect in signaling protein. Patient have pulmonary valve stenosis, VSD or hyperophic cardiomyopathy. 