<prompt> True about Nephrotic syndrome in a child a Minimal change disease is commonest causeb Proteinuria of 4 gmm2 hr is characteristicc Cyclosporine Azathioprine is mainstay of therapyd Pretreatment biopsy is done in all casese Spontaneous bacterial peritonitis is associated with itaaeabad  <response>: Nephrotic syndrome in childrenMost children 90 with nephrotic syndrome have a form of idiopathic nephrotic syndrome.Causes of idiopathic nephrotic syndrome are -i Minimal change disease 85 ii Mesangial proliferative GN iii FSGSInfections are a common complication of minimal change disease Nephrotic syndromeCommonly seen infections are - Spontaneous bacterial peritonitis most common, UTI, Sepsis, pneumonia and cellulitis.There is increased susceptibility to infections in minimal change disease because of -Urinary losses of immunoglobulins properdin factor B Malnutrition Defective cell-mediated immunity OedemaascitesImmunosuppressive therapyThe bacteria most commonly implicated in these cases are Streptococcus pneumoniae most common and E. coll. 