<prompt> Bone affection in scurvy is due to which of the followingPoor mineralization of the osteoid tissueDefective osteoid matrix formationDefective calcification in osteoidIncreased degradation of osteoid tissue  <response>: The most clearly established function of vitamin C is the activation of prolyl and lysyl hydroxylases from inactive precursors, allowing for hydroxylation of procollagen. Inadequately hydroxylated procollagen cannot acquire a stable helical configuration or be adequately cross-linked, so it is poorly secreted from the fibroblasts. Those molecules that are secreted lack tensile strength, are more soluble, and are more vulnerable to enzymatic degradation.collegen is required for osteoid matrix formation. Reference: Robbins basic pathology, pg no:301 