<prompt> Primary biliary cirrhosis is most commonly associated with___Systemic sclerosisSjogren syndromeUlcerative colitisPancreatitis  <response>: Primary Biliary Cirrhosis Autoimmune disorder Clinical manifestation - obstructive jaundice F M Antibody seen in antimitochondrial ab which is formed against E2 subunit of PDH enzyme. Interlobular bile ducts are actively destroyed by lymphoplasmacytic inflammation with or without granulomas. 