<prompt> Butterfly rash is seen inSystemic lupus erythematosusErythema marginatumLupus gulgarisErythema nodosum  <response>: A Systemic lupus erythematosus SLE: Characteristic Malar Butterfly rash seen as fixed erythematous rash over the cheeks, bridge of nose photosensitive but scarring is absent Patchy scalp hair loss is seen Hair usually regrow in SLE but not in DLE Raynauds phenomenon is present in 10; Antibodies against double-stranded DNA Anti ds DNA Anti Sm are most specific Where as Antinuclear antibody Anti SS DNA test is most sensitive; ANF Antinuclear factor is positive in 98 Treatment: Antimalarials Chloroquine, Hydroxychloroquine are used when skin joint disease predominate; Steroids with Ccytotoxic immunosuppressants Azathioprine, Cyclophosphamide, Methotrexate may be required when NSAIDS Antimalarials are insufficient to control symptoms 11 criteria for diagnosis of SLE are: Malar rash; Discoid rash; Photosensitivity; Oral ulcers; Arthritis; Serositis pleuritis, pericarditis; Renal disorder; Neurological disorder Seizures or Psychosis; Haematological disorder Haemolytic anaemia, Leukopenia, Thrombocytopenia; Immunological disorder;Antinuclear antibody. SLE may cause Libman Sachs Verrucous type of endocarditis 