<prompt> Which of the following metabolic abnormality is seen with long term use of spironolactone?Metabolic acidosisMetabolic alkalosisHyperkalemiaNone of the above  <response>: By inhibiting H secretion in parallel with K secretion, the K-sparing diuretics can cause acidosis similar to that seen with type IV renal tubular acidosis. Ref: Katzung, 11th edition, Chapter 15. 