<prompt> All are true regarding superantigens except?Activate very large numbers of B cellsBind outside the antibody binding grooveAre medium sized proteinsCause release of cytokines  <response>: Superantigens activate very large number of T cells. NON -MHC restricted They are medium sized proteins which Attach to TCR on lateral side on Vb Variable domain, outside the antibody binding groove. They cause release of cytokines that induce 20 of T lymphocytes activation resulting in massive proliferation of T lymphocytes. They have high resistance to proteases. 