<prompt> In treatment of osteosarcoma, all of the following are used exceptHigh dose methotrexateCyclophosphamideVincristineDoxorubicin  <response>: Ref: Katzung 10th891 Though surgery is the form of primary treatment in osteosarcoma but etoposide, cyclophosphamide, cisplatin and doxorubicin have been used. High dose methotrextae has been the drug of choice and is the only FDA approved agent for this condition. 