<prompt> Nobel prize in 2006 recently was given for the discovery ofLipoxinsRNAimt DNAβ-transcription factor  <response>: If an investigator introduces into an organism a duplex RNA molecule corresponding in sequence to virtually any mRNA, Dicer nuclease cleaves the duplex into short segments, called small interfering RNAs siRNAs. These short 21-25 nucleotide long si RNAs usually form perfect RNA-RNA hybrid with their targets potentially anywhere within the length of mRNA where the complementary sequence exists. Formation of such RNA-RNA duplexes between si RNAs and mRNA results in reduced specific protein production because the si RNA - mRNA complexes are degraded, mostly in specific cytoplasmic organelles termed P-bodies. The process is known as RNA interference RNAi for which Nobel prize was given to Andrew Fire Craig Mello in 2006. 