<prompt> JAK-2 mutation is strongly associated with?Burkitts lymphomaPolycythemia veraMultiple myelomaMantle cell lymphoma  <response>: Ans. is b i.e., Polycythemia vera Janus kinase 2 JAK2, a member of the Janus kinase family, is a non-receptor tyrosine kinase. JAK2 fusions with the TELETV6 TEL-JAK2 and PCM 1 have found to be associated with leukemia, particularly clonal eosinophilia forms of the disease. JAK-2 mutations are associated withi Polycythemia vera,ii Essential thrombocythemiaiii Myelofibrosis and other myeloproliferative disordersiv Abnormal heart defects 