<prompt> Unconjugated hyperbilirubinemia in a newborn can be caused by all the following EXCEPT:Dubin Johnson syndromeIneffective erythropoiesisGilberts syndromeCrigler - Najjar syndrome  <response>: Ans. a Dubin Johnson syndrome. Ref. Harrisons Principles of Internal Medicine 16th ed., 240Rotor syndrome and Dubin Johnson syndrome cause conjugated hyperbilirubinemia, due to impaired hepatic excretion lntrahepatic defect.Causes of unconjugated hyperbilirubinemia1. Defective Hepatic uptake:Eg. Flavospidic acid and Novobiocin2. Over production:a. Hemolysis Intra and extra vascularb. Ineffective erythropioesis3. Decreased hepatic uptake:a. Prolonged fastingb. Sepsis4. Decreased bilirubin conjugation: i.e., decreased hepatic glucuronosyl transferase activitya. Gilberts syndromeb. Crigler - Najjar type II moderate and type I Severec. Neonatal jaundiced. Acquired transferase deficiency:i Drugs chloramphenicol and pregnanediolii Breast milk jaundice due to pregnanediol and fatty acid in breast milkiii Hepatitis, Cirrhosise. SepsisRotor syndrome is a benign condition with deficiency of hepatic storage of conjugated bilirubin, resulting in its leakage in plasma. LFTs are normal and Rx is unneccersary. 