<prompt> Two cell two gonatotropin hypothesis is ?FSH LH inhibits the release of estrogen and progesteroneFSH acts on granulosa cell and LH on theca cellsFSH stimulates estrogen while LH inhibits estrogenFSH feedback inhibits hypothalmus, while LH feadback inhibits pituitary  <response>: Ans. is b i.e., FSH acts on granulosa cell and LH on theca cells The Two-cell, two-gonadotropin theory proposes that two cells i.e. theca cells and granulosa cells and the two gonadotropins i.e. FSH and LH stimulate estrogen synthesis. i FSH stimulate granulosa cells to secrete estrogen. ii LH helps indirectly in secretion of estrogen. LH stimulates theca interna cells to increase the synthesis of androgens which are taken up by granulosa cells and conveed to estrogen by aromatase. 