<prompt> The most common cardiovascular lesion in Down;s syndrome is:VSDEndocardial cushion defectTOFCOA  <response>: The most common cardiovascular lesion in Down;s syndrome is endocardial cushion defect. Other associated defects are atrial septum defectsASD, ventricular septum defectVSD, and patent ductus aeriosusPDA, aberrant subclan aery, and pulmonary hypeension. Clinical Features: Intellectual disabilityIncurved or sho fifth finger with clinodactyly Congenital hea disease Acute megakaryoblastic leukemiaAlzheimer;s diseaseAtlantoaxial instabilityAtresia of the duodenum Protruding tongue Round face Occiput flatOpen wide fontanelleOpen mouth BrachycephalicBrushfiel;s spots Low depressed nasal bridge Epicanthal foldEars low set and dysplastic Mongoloid slant Oblique palpebral fissure Simian palmar crease and wider gap between first and second toes. Ref: Nelson textbook of pediatrics 21st edition Pgno: 660 