<prompt> I time required to reach the steady state after a dosage regimen depends onRoute of AdministrationHalf life of drugDose intervalDosage of the drug  <response>: after a dosage regimen, concentraton of the drug to reach the stead state when the eliminaton balances the input is called steady state plasma concentration cpss cpss is reached in about 4-5 half lives. the amplitule fluctuations in Cpss depends on the dose interal relative t12 Ref-KDT 6e p32 