<prompt> What is the chance of HIV infection after needle prick injury?110013001100001 in 1 Lakh  <response>: Needle prick injury: HIV transmission following skin puncture from a contaminated needle is 0.3 and a mucous membrane exposure is 0.09. The seroconversion rate for HIV is 1:300, or 0.3 from a hollow-bore needle stick injury. Antiretroviral drugs as postexposure prophylaxis decreases the risk of infection. Must know: In Hepatitis B, the seroconversion ranges from 23 to 62, with higher rates associated with patients who are HBeAg positive, as compared to HBeAG negative. The seroconversion rate for Hepatitis C is 1.8. For Hepatitis C no prophylactic treatment is available. HBV post exposure prophlylaxis with hepatitis B immunoglobulin and initiation of Hep B vaccine is 90effective. Ref: Harrisons Principles of internal medicine, 16th edition, page 1081. 