<prompt> Marfan syndrome is due to mutation of:CollagenElastinFibrillinFibronectin  <response>: Marfan syndrome is caused by mutations in the FBN1 gene on chromosome 15, which encodes Fibrillin-1. Fibrillin normally binds to TGF-b Transforming Growth Factor Mutated fibrillin cant bind to TGF-b. Elevated levels of TGF-b contribute to the features of Ectopia lentis, arachnodactyly, and aoic dilatation. 