<prompt> In Beta thalassemia, the most common gene mutation is:Intron 1 inversionIntron 22619 bp deletion3.7 bp deletion  <response>: Ans. is a i.e., Intron 1 inversion The most common mutation causing a thalassemia is intronfinversionThalassemias are autosomal recessive disorder.The most common mutation causing thalassemias is introninversionAlso know:o Synthesis of alpha chain is controlled by 2 gene clusters on - Chromosome 16o Synthesis of beta chain is controlled by 2 gene clusters on - Chromosome 11Thalassemia mutations in IndiaMultationsFrequencyo IVS1-5G-Co 619 bp delectiono IVS-I G-To FR4142TCTTo FR89 G o CodonlS G-Ao Others48189956100 