<prompt> Which of the following is a prodrug of adrenaline used topically in glaucomaDorzolamideDipivefrinePhenylpropanolamineBrimonidine  <response>: a Adrenergic agonists Dipivefrine:- It is a prodrug of Adr; penetrates cornea and is hydrolysed by the esterases present there into Adr. The released Adr from dipivefrine lowers i.o.t. by augmenting uveoscleral outflow, b2 receptor mediated increase in hydraulic conductivity of trabecular filtering cells, as well as by reducing aqueous formation a1 a2 receptor mediated. Though better tolerated and longer acting than Adr, dipivefrine still produces significant ocular burning and other side effects. Ref:- kd tripathi; pg num:-154 