<prompt> Which of the following is true about Nodular Regenerative Hyperplasia?Nodule size 0.1 to 1 cmFibrosis septa presentPortal hypertension seen in 50 of patientsAST and ALT are markedly elevated  <response>: Ans: c Portal hypertension seen in 50 of patientsRef: Robbins Pathology, 9th editionFeatures of Nodular Regenerative Hyperplasia of LiverNodular hyperplasia diffusely affecting entire liver but with no minimal fibrous septaDevelops at all ages but usually symptomatic at age 40Associated with:Portal hypertensionConnective tissue disease rheumatoid arthritis, polyarteritis nodosaMyeloproliferative disordersLymphoproliferative disordersVascular disordersChemotherapyImmunosuppressive drugsAST - ALT mild elevation or normalPresents as non-cirrhotic portal hypertensionPathology Gross and Microscopy1-3 mm diameter nodulesNo fibrosis, only nodulesOn biopsy, apparent lack of central veins and presence of curvilinear areas of congestion are suggestiveReticulin stain highlights the fibrous nature 