<prompt> A female developing haemarrhagic cystitis, with following -- treatment5-FUMethotrexateBleomycinCyclophosphamide  <response>: Cyclophosphamide 320- CSDT 12th Haemorrhagic cystitis can develop in patients recieving cyclophosphamide or Ifosamide Other drugs causing hemorrhagic cystitis- Carmustine- Chlorumbucil- Extended spectrum penicilline- Nitrogen mustard- Vincristine Remember these following two very important points Hemorrhagic cystitis due to cyclophosphamide is attributed to the presence of its metabolite ACROLEIN in urine Hemorrhage cystitis due to cyclophosphamide can be prevented by I.V- injection of MESNA Sodium- 2 mercaptoethane sulfonate and adequate hydration Haemorrhagic cystitis is also seen in patients who undergo Bone marrow transplantation BMT In BMT setting1. Early onset haemorrhagic cystitis - due to drugs cyclophosphamide2. Late onset haemorrhagic cystitis - due to polyoma virus BKV or adenovirus type II 