<prompt> Which of the following is not involved in Wernickes - Korsakoff psychosis:Mamillary bodyThalamusPeriventricular Grey matterHippocampus  <response>: Answer is D Hippocampus: Hippocamous is not involved in Wernickes Korsakoff syndrome. Wernicke-Korsakoff syndrome WKS It is the combined presence of Wernickes encephalopathy WE and Korsakoffs syndrome. The cause of the disorder is thiamine vitamin B1 deficiency, which can cause a range of disorders including beriberi, Wernickes encephalopathy, and Korsakoffs psychosis. WKS is usually secondary to alcohol abuse. WE is characterized by the presence of a triad of symptoms; Ocular disturbances ophthalmoplegia Changes in mental state confusion Unsteady stance and gait ataxia KS is described as an acute onset of severe memory impairment without any dysfunction in intellectual abilities.The DSM IV lists the following criteria for the diagnosis of Korsakoffs Syndrome: anterograde amnesia Variable presentation of retrograde amnesia One of: Aphasia Apraxia Agnosia A deficit in executive functions. Wernicke-Korsakoff syndrome in alcoholics paicularly is associated with atrophyinfarction of specific regions of the brain, especially the mamillary bodies. Other regions include the anterior region of the thalamus accounting for amnesic symptoms, the medial dorsal thalamus, the basal forebrain, the median and dorsal raphe nuclei, periventricular gray matter, inferior and superior colliculi and the cerebellum. 