<prompt> Which of the following is not seen in acute hepatitis B infectionHBsAgHBeAgIgM Anti HBsAgIgG Anti HBsAg  <response>: Ans: d IgG anti HBsAg Ref:Ananathanarayan, 7th ed, p. 557IgG anti HBsAg is not a marker of acute Hep B infection, it is a marker of chronic Hep B infectionHBsAg Hep B surface antigen -It is a protein which is a part of viral envelope.HBcAgHep B core antigen-It is a protein which makes up the capsid or core part.It is found in liver not in blood.HBeAgHep B e antigen-It is a part of HBcAg which can be found in the blood and indicates infectivity.Schematic diagram of hepatitis B virusThis is one of the most important topics in entrance examination, so it is necessary to understand completely the serological patterns in HB V infection.Important points First virological marker detectable isHBsAgEarliest antibody marker in bloodIgM Anti HBcDiagnostic marker of acute Hep B infectionIgM Anti HBcMarker of infectivityHBeAgMarkers of replicative phase HBeAg - Qualitative markerHBV DNA - Quantitative markerAnti HBsAg without anti HBcVaccinatedAnti HBsAg with IgG anti HBcRecovery from infection 