<prompt> Which of the following is not involved with multiple endocrine neoplasia-I?PitutaryPancreasParathyroidThyroid  <response>: MEN-1 or Wermer syndrome Characterized by abnormalities : - Parathyroid: Primary hyperparathyroidism is most common manifestation of MEN-1. It is initial manifestation of disorder in most patients, appearing in almost all patients by age 40 to 50. - Pancreas: Endocrine tumors of pancreas are leading cause of morbidity moality in these pts. Tumors are usually aggressive often present with metastatic disease. Multiple microadenomas scattered throughout pancreas in conjunction with one or two dominant lesions are seen. - Pituitary: Prolactinoma is the frequent anterior pituitary tumor encountered in MEN-1 