<prompt> What propoion of Wegeners will have antibodies to Proteinase-3?105090100  <response>: There are two types of ANCA based on different targets for the antibodies. Cytoplasmic ANCA cANCA is the diffuse, granular cytoplasmic staining pattern observed by immunofluorescence microscopy when serum antibodies bind to indicator neutrophils. Proteinase-3 is the major c-ANCA antigen. ALSO NOTE: More than 90 of patients with typical active granulomatosis with polyangiitis Wegeners have detectable antibodies to proteinase-3 Ref: Harrison, E-18, P-2786. 