<prompt> An i.v. bolus dose of thiopentone leads to loss of consciousness within 1015 sec. The patient regains consciousness in just a few minutes. This is because it is:Renally excretedExhaled rapidlyRapidly metabolised by hepatic enzymesRedistributed from brain to other body tissues  <response>: Thiopentone and other highly lipid soluble agents first reach the highly perfused organs like the brain. Therefore, the onset of action of these agents is very quick. However, action also terminates quickly because of redistribution to less well-perfused tissues like fat and muscle. 