<prompt> Most common cause of cervical neoplasia isHPV 6HPV 11HPV 16HPV36  <response>: Human papilloma virus Oncogenic DNA virus which are grouped into high and oncogenic risk HPVsHigh oncogenic risk HPVsHPV16 and 18 -main cause of cervical cancers and also vaginal, vulvar, penile, anal, tonsillar and oropharyngeal carcinomas.Low oncogenic risk HPVs HPV 6 and 11 - causes vulvar, perineal and perianal condyloma accuminatum.HPV produce two envelope proteins-E6 and E7. E6 proteins inhibits p53, induce centrosome duplication, induce genomic instability and upregulates telomerase.E7 promotes cell cycle by binding to RB and upregulates cyclin E, induce centrosome duplication and induce genomic instability Ref: Robbins 8e p1018 