<prompt> Most common cause of Mediastinitis is:Tracheal ruptureEsophageal ruptureDrugsIdiopathic  <response>: Answer is B Esophageal rupture: Most cases of acute mediastinitis are due to esophageal perforation or occur after median sternotomy for cardiac surgery- Harrison Acute Mediastinitis Chronic Mediastinitis 1. 2. Esophageal rupture Q Median sternotomy for cardiac surgery 1. 2. 3. Tuberculosis Histoplasmosis most cases Q Sarcoidosis, silicosis Q Other fungal diseases 