<prompt> Therapeutic use of acetylcholine is not possible because it is -Highly protein boundRapidly degradedRepidly excretedOrally ineffective  <response>: Ans. is b i.e., Rapidly degraded o Acetylcholine is not used clinically because : I. It is metabolized very quickly by cholinesterase in plasma and is not effective even by i.v. route. 2. Action is nonselective 