<prompt> Giant hyperophy of gastric mucosa similar to brain surface is seen in -Peptic ulcerationCarcinoma stomachMenetriers diseaseLeomyosarcoma  <response>: Ans. is c i.e., Menetriers diseasesMenetrier disease o It is characterized by giant cerebrifrom similar to brain surface enlargement of rugal folds of gastric mucosa.o Enlargement of rugal folds is due to profound hyperplasia of surface mucous cells -- gastric secretion contain excessive mucus.o There is accompanying glandular atrophy -- gastric disease is more common in males in the fouh to sixth decades.o The hyperophic change may predominanty involve the body, fundus or antrum or may affect the entire stomach. o Patients develop protein losing gastropathy accoimpanied hypoalbuminemia and edema.o Infrequently, the mucosal hyperplasia becomes metaplastic, providing a soil for the develoment of gastric carcinoma. 