<prompt> The genomic proteins which are essential determinants of H. pylori-mediated pathogenesis and colonization are all, EXCEPT:Hop proteinsUreaseVacuolating cytotoxin Vac AVacuolating cytotoxin Vac B  <response>: The genome of H. pylori encodes 1500 proteins. Factors that are essential determinants of H. pylori-mediated pathogenesis and colonization are Outer membrane protein Hop proteins urease Vacuolating cytotoxin Vac A. The majority of H. pylori strains contain a genomic fragment that encodes the cag pathogenicity island cag-PAI. Several of the genes translocates Cag A into host cells. Once in the cell, Cag A activates a series of cellular events. Ref: Harrison-E-18,P-2442. 