<prompt> Prions are best killed byAutoclaving at 121degC5 formalineSodium hydroxideSodium hypochloride  <response>: Ans. is c i.e., Sodium hydroxide Incineration is apparently the only way of disinfecting prion-contaminated materials or tissues. Boiling or irradiation have no effect and even routine autoclaving at 121degC is not reliable. Therefore, where there is a risk of exposure, surgeons use disposable instruments. To sterilize reusable instruments, WHO currently recommends combined use of a strong solution of sodium hydroxide and extended autoclaving at 134degC. Autoclaving at 134degC for 5 hrs or treatment with 2 N NaOH for several hours is recommended for sterilization ofprions. Harrison 