<prompt> Which of the following drug can be used for closure of patent ductus aeriosus?ParacetamolAlprostadilIndomethacinCelecoxib  <response>: PGE2 and PGI2 keeps ductus aeriosus patent. If ductus aeriosus fails to close patent ductus aeriosus at bih, NSAIDs like aspirin and indomethacin are given to close it. In some congenital hea diseases like transposition of great vessels, it becomes essential to keep ductus aeriosus patent before surgery. For this indication, alprostadil PGE1 and epoprostenol PGI2 can be given intravenously. 