<prompt> Basophilic stippling is seen withThalassaemiaSickle cell anemiaMegaloblastic anemiaSplenectomy  <response>: i.e. Thalassaemia : 292-Harsh mohan 6th 658-H17th6thPunctate basophilia or basophilic stippling is diffuse and uniform basophilic granularity in the cell which does not stain positively with Perls reaction in contrast to pappenhamer bodies which stain positivelyExamples - Aplastic anaemia Thalassaemia Myelodysplasia Infections Lead poisoning Howell -Jolly bodies - present in Megaloblastic anemia and after splenectomy Basophilic leucocytosis indicative of CMLPYRIMIDINE 5 - NUCLEOTIDASE PSN DEFICIENCY - Highly distinctive feature of this condition is a morphological abnormality of the red cells known as basophilic stippling. This condition is rare but it probably ranks third in frequency among red cell enzyme defects after G6PD deficiency and pyruvate Kinase deficiency 658-H17th 