<prompt> Ram Prashad is admitted to Guru Teg Bahadur Hospital with respiratory infection for which antibiotic tobramycin is ordered. The clearance and Vd of tobramycin in him are 160 mlmin and 40 L, respectively. If you wish to give Ram Prashad an intravenous loading dose to achieve the therapeutic plasma concentration of 4 mgL rapidly, how much should be given?0.1 mg10 mg115.2 mg160 mg  <response>: Loading dose Vd x target plasma cone. 40 L x 4 mgL 160 mgClearance plays no role in the determination of loading dose. It is given to confuse you. 