<prompt> Loading dose of a drug depends upon:Volume of distributionClearanceHalf lifeDuration of action  <response>: Ans. A Volume of distributionRef: KDT 8th41Loading dose: It is mainly used for drugs having long t12 and large volume of distribution. It is given to load saturate the tissue stores. So it is mainly dependent on Vd.Loading dose VD x Target plasma concentrationMaintenance dose: It is mainly dependent on CL.Maintenance dose CL x Target plasma concentration 