<prompt> Infant with cystic fibrosis CF are likely to develop a Meconitun ileusb Loose motionsc Vomitingd Constipationbcacad  <response>: Cystic fibrosis Cystic fibrosis mucoviscidosis is a hereditary disease affecting the exocrine mucus glands of the lungs, liver, pancreas and intestines, causing progressive disability due to multisystem failure.It has an autosomal recessive pattern of inheritance.PathogenesisThe basic defect in CF is a mutation in the cystic fibrosis transmembrane regulator CFTR gene that regulates chloride conductance channel in the outer membrane of exocrine glands.Mutation in the CFTR gene Dysfunction of chloride conductance channel of exocrine glands Lack of chloride conduction Secretion of glands becomes more viscous and thick Blockade of respiratory tract and ducts of exocrineglands by thick viscid mucus Manifestations of CFClinical manifestations1 Lungs and sinus diseaseSinusitis Bronchiectasis Lower respiratory tract infectionNasal polyps Chronic lung disease Pulmonary hypertension can cause heart failure Allergic bronchopulmonary aspergillosis 2 GIT, Liver and pancreasMeconium ileusRectal prolapseMalabsorptionPancreatitis Constipation Intussusception Meconium peritonitis Bile duct obstruction and biliary cirrhosis 3 Endocrine and growthDiabetes Osteoporosis Poor growth 4 InfertilityIn men due to the absence of vas deference In women due to thick cervical mucus. 