<prompt> All are true about losartan, EXCEPT :Angiotensin II antagonistCauses hyperuricemiaDoes not cause coughLong acting metabolites  <response>: Ans. is b causes hyperuricemia Ref KDT 5the p 453 page 208, 4thelLosartan is a mild uricosuric agent, i.e causes hypouricemia Losartan is a competitive antagonist of angiotensin II 10000 times more selective for AT1 than AT2.It blocks all overt actions of AILIn liver it gets converted to long acting metabolite E 3174 which is 10-30 times more potent non competitive antagonist of AT1Plasma t 12 of Losartan - 2hr E3174 - 6-9 hrs.It has several advantages over ACE inhibitorsIt does not cause coughIt does not cause dysgeusia altered taste sensationIt does not cause first does hypotensionSimilarities with ACE inhibitorHyperkalemia and hypotension Teratogenic 