<prompt> Nitrogylerine is effective when admistered sublingually because it isNon ionized and lipid solubleIonized and lipid solubleNon ionized and water insolubleIonized and water water insoluble  <response>: Nitroglycerin is effective when retained sublingually because it is non inonized and has very high lipid solubiility.thus the drug is absorbed very quickly Refer KDT 7the P6 