<prompt> Dinitrophenol causesInhibition of ATP synthaseInhibition of electron transpoUncoupling of oxidation and phosphorylationAccumulation of ATP  <response>: Mechanism of Action of DNP as uncoupler Dinitrophenol DNP a potent uncoupler is ampipathic and increase the permeability of the lipoid inner mitochondrial membrane to protons H, thus reducing the electrochemical potential and sho-circuiting the ATP synthase. In this way, oxidation can proceed without phosphorylation. Note: DNP was used for weight loss. But it was discontinued due to hypehermia and other side effects.Ref: MN Chatterjea Textbook of Medical Biochemistry, 8th edition, page no: 146 