<prompt> Esophageal adenocarcinoma is predisposed byAchalasiaSclerodermaCorrossive intakeAll  <response>: Answer is B Scleroderma Barrets esophagus is the characteristic risk factor for adenocarcinoma esophagus. Scleroderma also increases the risk of esophageal adenocarcinoma perhaps through the development of Barrets esophagus as the collagen deposits in the distal esophagus cause LES dysfunction. Risk factors for esophageal adenocarcinoma Current Gastroenterology Barrets esophagus Gastroesophageal Reflux Disease GERD Scleroderma Smoking Alcohol History of colon cancer Medications Long term use 5 years of Theophylline agonists. 