<prompt> Coagulation defect associated with increased coagulation are seen inIncreased protein CIncreased protein SIncreased anti thrombin 3Protein C resistance  <response>: Ref Harrison 16e p1491 ,9e p123 Protein C and protein S are two vitamin K-dependent proteins that act in a complex to proteolytically inacti- vate cofactors Va and VIIIa. Protein C activation by thrombomodulin was described earlier; protein S is a cofactor for protein C activity Resistance to activated protein C due to the factor V R506Q Leiden mutation is the most common clotting abnormality in patients with venous thromboembolism 