<prompt> What is false regarding McDonald criteria for diagnosis of MS?Dissemination in spaceDissemination in timeNeurological disturbance consistent with MSOligoclonal IgG bands in serum  <response>: Ans DThe McDonald Criteria incorporates clinical evaluation with magnetic resonance imaging MRI scans in establishing MS: Evidence of damage to the central nervous system CNS; the brain, spinal cord and optic nerves that is disseminated in time, meaning damage that occurs on different dates; Evidence of damage disseminated in space, or found on two or more parts of the CNS.A 2010 revision to the McDonald Criteria which followed a 2005 update reflected better understanding of MS and improved MRI techniques and made possible a faster diagnosis -- one that is, for a first time, potentially based on only one demyelinating relapse or attack provided certain criteria are met. These new criteria are dissemination in time, if two lesions are evident at a first attack, and dissemination in both time and space if only one lesion is evident. Oligoclonal bands should be present in CSF and not serum in diagnosis of multiple sclerosis. 