<prompt> Treatment of simple Endometrial hyperplasia with atypia in a 48 year old woman:-HysterectomyMedroxy progsterone acetateLevonorgesterel IUCDObservation  <response>: The incidence of endometrial cancers with Simple hyperplasia with out Atypia is 1 Complex hyperplasia with out Atypia 3 Simple hyperplasia with Atypia 8 Complex hyperplasia with Atypia 29 Treatment Endometrial hyperplasia without atypia : Progesterone therapy should be given, even if the risk of malignancy is less Endometrial hyperplasia with atypia : Total hysterectomy. Here the patient is perimenopausal with an 8 chance of developing cancer, therefore it is advisable for patient to undergo hysterectomy. 