<prompt> Pagets disease of anal canal is:Squamous cell carcinoma in situSquamous cell adenomaIntra-epithelial adenocarcinomaMarginal anal cell carcinoma  <response>: Ans. c Intra-epithelial adenocarcinoma Ref: Sabiston 19th Edition, Page 1405Pagets Disease of Anal Canal Its the superficial manifest of an intraepithelial adenocarcinoma. Most common site is breast Most common site of extra mammary Pagets disease- Anogenital Axilla Most common site in females: Vulva Pagets cells- Foamy and Vacoulated, PASve , Mucicarmine and Alcian blue , Cytokeratin 7 is also positive Diagnosis made on biopsy Wide local excision is treatment of choice. 