<prompt> According to WHO the major sign of AIDS in chil- dren in stage I is the following -Generalised lymphadenopathyNot gaining weightOral candidiasisAll of above  <response>: Ans. is a i.e.. Generalised lymph adenopathy Revised WHO clinical staging of HI V,A IDS for infants and childreno Clinical Stage 1AsymptomaticPersistent generalized Lymphadenopathyo Clinical Stage 2HepatosplenomegalyPapular pruritic eruptionsSeborrhoeic dermatitisExtensive human papilloma virus infectionExtensive molluscum contagiosumFungal nail infectionsRecurrent oral ulcerationsLineal gingival erythema LGEAngular cheilitisParotid enlargementHerpes zosterRecurrent or chronic RTIs otitis media, otorrhoea, sinusitiso Clinical Stage 3Moderate unexplained malnutrition not adequately responding to standard therapyUnexplained persistent diarrhoea 14 days or more Unexplained persistent fever intermittent or constant, for longer than one monthOral candidiasis outside neonatal period Oral hairy leukoplakiaAcute necrotizing ulcerative gingivitis-periodontitisPulmonary TBSevere recurrent presumed bacterial pneumonia Conditions where con?rmatory diagnostic testing is necessaryChronic HIV-associated lung disease including bronchiectasisLymphoid interstitial pneumonitis LIPUnexplained anaemia 8gdl, and or neutropenia 1000mm3 and or thrombocytopenia 50 000 mm3 for more than one montho Clinical Stage 4Unexplained severe wasting or severe malnutrition not adequately responding to standard therapyPneumocystis pneumoniaRecurrent severe presumed bacterial infections e.g. empyema, pvomyositis, bone or joint infection, meningitis, but excluding pneumonia.Chronic herpes simplex infection; orolabial or cutaneous of more than one months durationExtrapulmonaiy TBKaposis sarcomaOesophageal candidiasisCNS toxoplasmosis outside the neonatal periodHIV encephalopathyConditions where confirmatory diagnostic testing is necessaryCMV infection CMV retinitis or infection of organs other than liver, spleen or lymph nodes; onset at age one month or moreExtrapulmonaiy cryptococcosis including meningitisAny disseminated endemic mycosis e.g. extrapulmonaiy histoplasmosis, coccidiomycosis, penicilliosisCryptosporidiosisIsosporiasisDisseminated non-tuberculous mycobacteria infectionCandida of trachea, bronch i or lungsVisceral herpes simplex infectionAcquired HIV associated rectal fistulaCerebral or B cell non-Hodgkin lymphomaProgressive multifocal leukoencephalopathy PMLHIV-associated cardiomyopathy or HIV-associated nephropathy 