<prompt> Fully humanized antibody that is used in the treatment of rheumatoid arthritis isEtanerceptAnakinraInfliximabAdalimumab  <response>: Ref: Katzungs Basic and Clinical Pharmacology; 9e,pg592Adalimumab:Adalimumabisarecombinanthumananti-TNFmonoclonalantibody.This compound complexes with soluble TNF-α and prevents its interaction with p55 and p75 cell surface receptors.This results in down-regulation of macrophage and T-cell function. Option a: EtanerceptRef: Katzungs Basic and Clinical Pharmacology; 9e, pg 593Etanerceptis are combin ant fusion protein consisting of two soluble TNF p75 receptor moieties linked to the Fc portion of human IgG1.It binds TNF-α molecules and also inhibits lymphotoxin-α. Option c: InfliximabRef: Katzungs Basic and Clinical Pharmacology; 9e, pg 592Infliximab is a chimeric 25 mouse, 75 human monoclonal antibody that binds with high affinity to soluble and poorly membrane-bound TNF-α.Its mechanism of action is probably the same as that of adalimumab. Option b: AnakinraRef: K.D.Tripathis Essentials of Medical Pharamacology; 6e, pg 205.It is a recombinant human IL-1 receptorantagonist.Though clinically less effective than TNF-α inhibitors, it has been used in cases who have failed on one or more DMARDs.Dose: 100 mg s.c.daily. 