<prompt> True about COX-2 are all except-It is constitutionally expressed on some cell surfacesActivation of COX-2 leads to ulceroprotective effect on gastric mucosaInduced at the site of inflammationIt is utilized in generation of eicosanoids with a ring structure  <response>: Ans. is b i.e., Activation of COX-2 leads to ulceroprotective effect on gastric mucosa It has been explained earlier that COX-2 is an inducible enzyme. But, At two sites it is constitutively active i Kidney ii Brain o Induction of cyclooxygenase COX will enhance the production of prostaglandins, which have ulceroprotective effect. But, it is COX-1 not COX-2 which acts at stomach and produces gastroprotective effect -- so, COX-2 inhibitors usually dont have gastrointestinal side effects unlike COX-1 inhibitors which have gastrointestinal side effects. o COX-2 is an inducible enzyme -3 induced at the site of inflammation. o COX-2 is involved in the synthesis of prostaglandins PGs are eicosanoids which have cyclopentane ring ring structure. 