<prompt> Treatment with herceptin in breast cancer is indicated forER receptor ve tumoursPR receptor ve tumoursK : 67 stain ve tumoursTumours with over-expressed C-erb B-2 protein  <response>: Treatment with herceptin in breast cancer is indicated for Tumours with over-expressed C-erb B-2 protein it is a inhibitor of C-erb B-2 protein, which is a growth factor receptor also known as Transtuzumab it is currently approved by FDA for use only in metastatic disease ref ;page no;551 5th edition of SRB;S Manual of SURGERY 