<prompt> True about panacinar emphysema: March 2011Apical region commonly involvedUsually presents in 6th decadeAlpha-1 antitrypsin deficiencyInvolves whole lung  <response>: Ans. C: Alpha-1 antitrypsin deficiency Panacinar emphysema refers to abnormally large airspaces evenly distributed within and across acinar units. Panacinar emphysema is usually observed in patients with alphal-antitrypsin deficiency Emphysema pink puffers: Permanent and destructive enlargement of airspaces distal to the terminal bronchioles without obvious fibrosis and with loss of normal architecture Panacinar emphysema involves both central and peripheral poions of the acinus Smoking is the commonest precipitant Breathlessness is characteristic feature 