<prompt> Crohns disease is associated with polymorphisms inNOD2CARD 15 geneP53 genePhiladelphia chromosomeAPCBeta catenin  <response>: Individuals with allelic variants of CARD15NOD2 have a 40 fold relative risk for Crohns disease compared with general population. Reference : Sabiston Textbook of Surgery, 19th Edition, page no 1245. 