<prompt> Why does decreased glycolytic activity impair oxygen transpo by hemoglobin?Due to reduced energy productionDue to decreased production of 2,3-bisphosphoglycerateDue to reduced synthesis of hemoglobin at low levels of oxygenNone of the above  <response>: 2,3-Bisphosphoglycerate 2,3-BPG is the most abundant organic phosphate in the erythrocytes. It is produced in the erythrocytes from an intermediate 1,3-biphosphoglycerate of glycolysis. This sho pathway is called Rapapo-Leubering cycle. It normally binds to hemoglobin and decrease its affinity to oxygen and thereby helps in oxygen delivery. When glycolytic activity is reduced, oxygen transpo by hemoglobin is impaired due to decreased production of 2,3 BPG. In hypoxia and anemia 2,3-BPG in the erythrocytes is elevated. Ref: Essentials of Biochemistry, Satyanarayanan, Page 108 