<prompt> Causes for less bioavailability -High first pass metabolismIncreased absorptionIV drug administrationHigh solubility  <response>: Ans. is a i.e., High first pass metabolism o Causes for less bioavailability. Incomplete absorption o High first pass metabolism. About other options Increased absorption increases bioavailability. o I.V. administration has 100 bioavailahi I ity. High lipid solubility causes more absorption and better bioavailability. 