<prompt> Which of the following is the wrong statement regarding sarcoidosis?Lung is the most common organ affectedLupus pernio is diagnostic of chronic form of sarcoidosisHypercalcemia occurs in 10 of sarcoidosis patients.Increased CD4CD8 ratio in serum suppos sarcoidosis  <response>: Sarcoidosis is an inflammatory disease characterized by the presence of noncaseating granulomas. Although sarcoidosis can affect viually every organ of the body, the lung is most commonly affected. Studies suggest that a mycobacterium similar to M. tuberculosis could be responsible for sarcoidosis. Hypercalcemia andor hypercalciuria occurs in about 10 of sarcoidosis patients. The mechanism of abnormal calcium metabolism is increased production of 1,25-dihydroxy vitamin D by the granuloma itself. The 1,25-dihydroxy vitamin D causes increased intestinal absorption of calcium, leading to hypercalcemia with a suppressed parathyroid hormone PTH level. A specific complex of involvement of the bridge of the nose, the area beneath the eyes, and the cheeks is referred to as lupus pernio and is diagnostic for a chronic form of sarcoidosis. This form of sarcoidosis is associated with involvement of the upper respiratory tract. Ref: Harrison;s Principles of Internal Medicine; 20th edition; Chapter 390 Sarcoidosis 