<prompt> As the glomerular filtrate passes through the uriniferous tubule, ions and water are exchanged actively and passively with the renal interstitium. These exchanges result in the filtrate being isotonic, hypotonic or hypeonic relative to blood plasma. What would be the tonicity of the filtrate passing through the renal capsular Bowmans space?IsotonicHypotonicHypeonicHyposmotic  <response>: Filtration in the renal corpuscle provides an isotonic isosmotic ultrafiltrate of blood plasma that enters Bowmans space. Filtrate leaving the coical collecting tubules, because of the presence of ADH antidiuretic hormone becomes hypeonic hypoosmotic by the time it reaches medullary collecting tubules. The filtrate approaching the distal convoluted tubules from the loop of Henle, on the other hand, even in the presence of ADH, becomes hypotonic hyperosmotic. Ref: Reilly R.F., Jackson E.K. 2011. Chapter 25. Regulation of Renal Function and Vascular Volume. In L.L. Brunton, B.A. Chabner, B.C. Knollmann Eds,Goodman Gilmans The Pharmacological Basis of Therapeutics, 12e. 