<prompt> Secondary ossification centre appears before bih atUpper end of femurLower end of femurLower end of tibiaLower end of fibula  <response>: Long Bone Diaphysis shaft - derived from primary ossification center. present at 6 - 8 weeks of IUL. Epiphysis ends - derived from secondary ossification center. appear after bih Except - Lower end of femur sometimes upper end of tibia. Their secondary ossification center appears before bih. 