<prompt> Which of the following is a good prognostic factor in ALL:High WBC countMale sexAge 2 yearsHyperdiploidy  <response>: Answer is D Hyperdiploidy: Hyperdiploidy is associated with a good prognosis Hyperdiploidy is associated with a good prognosis Patients with hyperdiploidy 50 chromosomes or DNA index 0.16 have a ourable prognosis - Age 2 years has a poor prognosis Patients who are very young 2 years and older patients 10 years tend to have a worse prognosis- lthough most textbooks use the criteria of Age 1 year to define a poor prognostic factor, Age 2 year has been mentioned as a poor prognostic factor in ceain textbooks including Hoffmans Hematology 4th1158 Since Hyperdiploidy provided amongst the option is an established good prognostic factor, this is selected as the single best answer of choice. High WBC count is associated with a poor prognosis Initial leukocyte count at diagnosis has proved to be an impoant prognostic factor in viually every ALL study. Different studies textbooks quote different values for the initial WBC count that is associated with a poor prognosis but uniformly a high WBC count carries a poor prognosis. Different text books Favourable WBC count Unourable WBC count Wintrobes Hematology 10,000 20,000 Hoffman Hematology 50,000 50,000 Manual of Clinical oncology 30,000 30,000 Inference Low WBC count High WBC count Male sex is associated with a poor prognosis Female patients have a rare ourable prognosis 