<prompt> Emphysema is due to deficiency ofTumor necrosis factorProstaglandinsLeucotriensAlpha - 1 antitrypsin  <response>: D. i.e. Alpha - 1- antitrypsin 486 - Harsh Mohan 5th 486- Basic pathology 8thEmphysema - is characterized by abnormal permanent enlargement of the airspaces distal to the terminal bronchioles accompanied by destruction of their walls without obvious fibrosisal - AT develops in adults and causes pulmonary emphysema in smokers as well as in non smokers Charcot- Leyden crystal and Curshmanns spirals are seen in B. asthma Panacinar Pan lobular emphysema is associated with a-1 AT deficiency 