<prompt> Intravenous PA is indicated in ischemic stroke within how many hours of onset of disease process1 hour3 hours6 hours12 hours  <response>: Answer- B. 3 hoursThe National Institute of Neurological Disorders and Stroke NINDS recombinant tPA PA Stroke Study showed a clear benefit for IV PA in selected patients with acute stroke.The NINDS study used IV PA 0.9 mgkg to a 90-mg max; l0 as a bolus, then the remainder over 60 minutes versus placebo in patients with ischemic stroke within 3 hours of onset. 