<prompt> Withdrawal of which of the following causes piloerecton ?MorphineCannabisSmokingAlcohol  <response>: Ans. is a i.e., Morphine Morphine withdrawalo Manifestations of morphine withdrawal Lacrimation Anxiety fear Mydriasis Diarrhea Palpitation Sweating Restlessness Insomnia Dehydration Rapid weight loss Yawning Gooseflash Piloerection Abdominal colic Rise in BP o Delirium and convulsions are not a characteristicfeatures contrast barbiturates and are seen only occasionally.o Treatment consists of withdraw! of morphine and substitution with oral methadone followed by gradual withdrawl of methodone.o Recently the NMDA antagonists and nitric oxide synthatase inhibitors have been found to block morphine tolerance and dependance. 