<prompt> c-ANCA positivity indicates, antibody formed against:Proteinase 3MyeloperoxidaseCytoplasmic antinuclear antibodyAnti centromere antibody  <response>: Answer is A Proteinase 3: Proteinase - 3 a 29 - kDA serine proteinase present in neutrophil azurophilic granules is the major c-ANCA antigen. Major c-ANCA antigen Proteinase 3 PR-3 Major p - ANCA antigen Myeloperoxidase MPO 