<prompt> In pemphigus vulgaris, antibodies are present against:Basement membraneIntercellular substanceCell nucleusKeratin  <response>: In Pemphigus antibodies are directed against desmoglein a trans membrane desmosomal glycoprotein belonging to cadherin-a calcium dependent adhesion molecule in intercellular substance causing loss of cohesion between epidermal cells of st. basale layer It formation of acantholytic cells which can be seen on Tzank smear. . 