<prompt> Thrombopoietin is produced by-MonocytesLiverMegakaryocytesMegakaryoblasts  <response>: Thrombopoietin is present in the blood as well as in a bound state with the platelets. It also binds with the megakaryocytes. It is produced by the liver and the kidneys. When thrombocytopenia reduction in platelet count occurs, thrombopoietin level in blood rises. This helps the megakaryocytes in producing new platelets rapidly. 