<prompt> Regarding newer formulations of amphotericin B, which of the following statements is accurate?Amphotericin B colloidal dispersion cause less infusion related reactions than conventional amphotericin B.They are more effective in fungal infections than conventional preparations because they increase tissue uptake of amphotericin BThey have decreased systemic toxicityThey have wider spectrum of antifungal activity than conventional formulations of amphotericin B  <response>: NEWER FORMULATIONS OF AM-B : Has Decreased systemic toxicity AMPHOTERICIN B COLLOID DISPERSION ABCD - MAX INFUSION RELATED REACTION AMPHOTERICIN B LIPID COMPLEX ABLC LIPOSOMAL AMPHOTERICIN B USED FOR TT OF KALA AZAR -MINIMUMINFUSION RELATED REACTION Lesser uptake in the tissues like kidney More expensive Similar in efficacy and antifungal spectrum as conventional preparations AMPHOTERICIN B CONVENTIONAL Usually given in slow iv infusion Very well distributed all over the body and poorly distributed in CN 