<prompt> A 25-year-old asymptomatic female underwent a preoperative coagulation test. Her BT is 3, PT is 1514, aPTT is 4535, platelet count 2.5 Iacmm3 and factor VIII levels were 60 IUdL. She most likely has:Factor IX deficiencyVon-Willebrands disease type IIIFactor VIII inhibitorsLupus anticoagulant  <response>: Ans. c. Factor VIII inhibitors Ref: Wintrobes 12e p1447-1453; Harrison 19e p734-735, 740, 18e p982This is a case of 25-year old asymptomatic female, BT is 3 normal, PT is 1514 normal, aPTT is 4535 raised, Platelet count is 2.5 lac mm3 normal and Factor VIII levels were 60 IUdL normal i.e. between 50-150. She most likely to has factors VIII inhibitors.Factor IX deficiency Both PT and PTT are increasedVon-Willebrands disease-Type III Prolonged Bleeding time Normal platelet count and PT Prolonged PTTFactor VIII Inhibitors Acquired coagulant inhibitor is immune-mediated condition characterized by autoantibody against a specific clotting factor and factor VIII is most common target. In 50 of patients no underlying disease is identified at the time of diagnosis. In remaining the causes are autoimmune diseases, malignancies, dermatologic diseases, pregnancy and post partum. Diagnosed by isolated prolongation of PTT with normal PT coagulation profile is similar to hemophilia A Normal platelet count and bleeding timeLupus Anticoagulant Mild thrombocytopenia Prolonged PTT Hypoprothrombopenia due to antibodies against prothrombin. 