<prompt> The following is not a feature of Alzheimers disease:Neurofibrillary tanglesSenile neuritic plaquesAmyloid AngiopathyLewy bodies  <response>: D Lewy bodies Lewy bodies are intraneuronal, intracytoplasmic, eosinophilic inclusions that have a dense core surrounded by a pale halo. They are composed by Neurofilaments and contain epitopes recognized by antibodies against neuro filament proteins, Ubiqutin and a-synuclein presynaptic protein They are characteristically seen in idiopathic parkinsons disease and not in Alzheimers disease Alzheimers disease is the most common cause of dementia in the Western world and is characterized by the following clinical, pathological and biochemical triad. Clinically:w Subtle onset memory loss followed byw Slowly progressive dementia over several years PathologicallyGross Diffuse atrophy of cerebral cortex Secondary enlargement of ventricular system Microscopic Neuritic plaques containing b amyloid Neurofibrillary tangles Amyloid angiopathy accumulation of b amyloid in arterial walls of cerebral blood vessels. Biochemically Decrease in cerebral cortical levels of acetyl choline choline acetyl transferase CAT and nicotinic cholinergic receptors are also reduced Reduction in ACH is related to degeneration of nucleus basalis of Meynert Lewy bodies are not mentioned as feature of Alzheimers disease. Diffuse Lewy body disease Dementia Large number of Lewy bodies in cortical neurons No other pathological findings Diffuse Lewy body variant of Alzheimers disease and not in Alzheimers disease Dementia Large number of Lewy bodies in cortical neurons Neurofibrillary tangles and amyloid plaques. 