<prompt> False statement about bilirubin isBilirubin circulating in plasma by covalently binding with albuminBilirubin is taken up across the sinusoidal basolateral membrane of hepatocytes by a carrier-mediated mechanismConjugated bilirubin in plasma undergoes stool eliminationConjugated bilirubin is then directed primarily toward the canalicular apical membrane  <response>: Bilirubin transpo: Bilirubin circulates in plasma noncovalently, bound to albumin. It is taken up across the sinusoidal membrane of hepatocytes by a carrier-mediated mechanism. Bilirubin uptake is mediated by a liver-specific sinusoidal organic anion transpo protein, OATP1B1, SLC21A6 Then bilirubin is directed by cytosolic binding proteins e.g., glutathione S-transferase B, fatty acid binding protein to the ER. It is conjugated with uridine diphosphate UDP-glucuronic acid by the enzyme bilirubin UDP-glucuronyl transferase B-UGT. Conjugated bilirubin is directed toward the canalicular membrane, and it is transpoed into the bile canaliculus by an adenosine triphosphate ATP-dependent pump. The responsible protein is multidrug resistance-associated protein-2 MRP2, ABCC2 Small amounts of bilirubin glucuronides are secreted across the sinusoidal membrane MRP3 ABCC3 Conjugated bilirubin in plasma undergoes renal elimination Ref: Sleisenger and Fordtrans, E-9, P-324 