<prompt> Inhalational halogenated anesthetics may cause malignant hyperthermia in372- KDT 6th Lippincotts 3rd pharmacologyPatients with poor renal functionPatients allergic to the anestheticsAlcoholicsGenetic defect in calcium channel at sarcoplasmic reticulum of the skeletal muscle  <response>: D. i.e. Genetic defect in calcium channel at sarcoplasmic reticulum of the skeletal muscle 372-KDT 6thMalignant Hyperthermia - occurs in small population who have a genetic defect in the muscle ryanodine receptor calcium channel at the sarcoplasmic reticulum of the skeletal muscle.Which is triggered by halothane to release massive Ca intracellularly causing persistent muscle contraction and increase heat production. Succinylcholine - accentuates the conditions.Treatment Rapid external cooling Bicarbonate infusion 100 O2 inhalation IV Dantrolene 1. Thiopental is a potent anesthetic but weak analgesic2. Nitrous oxide - is potent analgesic but weak general anesthetic Propofol is agent of choice for induction in susceptible individuals for malignant hyperthermia 