<prompt> Premature ovarian insufficiency is defined as hypogonadotropic hypogonadism and amenorrhea arising before the age of40 years45 years50 years55 years  <response>: Premature ovarian failure POF, traditionally defined as hypogonadotropic hypogonadism and amenorrhea arising before the age of 40.Reference: Clinical gynecologic endocrinology; 10th edition; Chapter 9; Normal and Abnormal Sexual Development; Page no: 463 