<prompt> Anti-inflammatory action of coicosteroids is due to blocking of-15 Lipo oxygenaseProstaglandin synthasesThromboxane synthasesBreakdown of phospholipids  <response>: Ans. is d i.e., Breakdown of phospholipids o The most impoant mechanism of coicosteroids as antiinflammatory agents is the limitation of recruitment chemotaxis of inflammatory cells at the local side and production ofproinflammatory mediators like PGs, LTs, PAF through inhibition ofphospholipase At o Phospolipase A, acts on membrane phospholipids and causes their breakdwon to form arachidonic acid. This is inhibited by coicosteroids. 