<prompt> Within the endocrine system, specificity of communication is determined byThe chemical nature of the hormoneThe distance between the endocrine cell and its target cellsThe presence of specific receptors on target cellsAnatomical connections between the endocrine and target cells  <response>: Hormones produce their effects on target cells by interacting with specific receptors. Hormone binding to its receptor generally initiates a cascade of events that lead to biological effects in the target cells. 