<prompt> True statements about neostigmine areIt is a quaternary ammonium compoundsIt is metabolized by the liverIt can cross the blood brain barrierProminent effect on cardiac muscle  <response>: Ref. KDT6e p101-102; Lee 12ep217 Neostigmine is a reversible cholinesterase inhibitor.It is a quaernary ammonium compound. lipid insolube agent, so it does not cross blood-brain-barrie. It is paly hydrolyzed by serum cholinesterase and paly excreted unchanged by the kidneys. It possesses some agonistic action on NM receptors. 