<prompt> Defect seen in Hailey Hailey disease?ATP2A2ATP2C1ATP7AATP7B  <response>: Hailey-hailey disease Benign familial pemphigus Occurs due to defect in gene: ATP2C1 gene which codes for: SERCA Sarco Endoplasmic reticulase Ca2 ATPase. Therefore, in this disease Ca2 ATPase is defective. Ca2 required for attachment of two desmosomes. ATP7A mutation causes Menkes disease. ATP7B mutation - Wilsons disease ATP2A2 mutation - Dariers disease. 