<prompt> Superior orbital fissure syndrome - following nerves are affected -C.N.1,2,4,6C.N. 2, 3, 4, 6C.N. 3, 4, 5, 6C.N. 1, 2, 3, 4, 5  <response>: Ans. is c i.e., C.N. 3, 4, 5, 6 o The superior orbital fissure is a cleft between the lesser and greater wing of sphenoid.The structures passed through superior orbital fissure are 3rd, 4th, 6th nerve, ophthalmic division of 5th nerve, superior inferior division of ophthalmic vein and sympathetic fibres. Therefore symptoms of superior orbital fissure syndrome are same as in cavernous sinus thrombosis, i.e., painful ophthalmoplegia :- Pain retro-orbital pain and sensory disturbances in the V1 ophthalmic division of 5th nervedistributionIpsilateral ophthalmoplegia 3rd, 4th and 6th nerve involvement. 