<prompt> Trisodium phosphonoformate foscarnet is a potent antiviral agent for treating herpes simplex infections. It works by affectingThe viral RNA polymeraseThe viral DNA polymeraseThe viral reverse transcriptaseThe host-cellular DNA polymerase  <response>: Trisodium phosphonoformate foscarnet inhibits herpes simplex virus HSV replication. Foscarnet is a potent inhibitor of HSV-induced DNA polymerase, and has little effect on known cellular DNA polymerases. Herpesvirus mutants resistant to the drug arise easily. To a lesser extent, foscarnet also appears to inhibit the polymerase of hepatitis B virus and retroviruses. Combinations of antivirals, including foscarnet, are currently prescribed to increase the clinical usefulness of the drugs.. 