<prompt> A 15-year-old boy presented with one day history of bleeding gums, subconjunctival bleed and purpuric rash. Investigations revealed the following results: Hb-6.4 gmdL; TLC-26,500mm3 Platelet 35,000 mm3; prothrombin time-20 sec with a control of 13 sec; paial thromboplastin time-50 sec; and Fibrinogen 10mgdL. Peripheral smear was suggestive of acute myeloblastic leukemia. Which of the following is the most likely?Myeloblastic leukemia without maturationMyeloblastic leukemia with maturationPromyelocytic leukemiaMyelomonocytic leukemia  <response>: The child presented with acute onset of bleeding, along with the following laboratory findings: Thrombocytopenia 35000mm3 as compared to normal value of 1, 50,000mm3 Increased prothrombin time 20s as compared to control of 13s Increased paial thromboplastin time 50s vs. normal 26-32s Decreased fibrinogen 10 mgdL vs. normal of 233- 496 mgdl These hematological abnormalities indicate disseminated intravascular coagulation. Most common form of AML associated with DIC is M3-AML Acute promyelocytic leukemia. All-trans retinoic acid ATRA, an analogue of vitamin A induce the neoplastic promyelocytes to differentiate into neutrophils rapidly and decrease chance of DIC. other agent useful is AsO3arsenic trioxide. 