<prompt> The MOST frequent genetic aberration associated with pancreatic malignancy is:KRAS mutationc-SrcSMAD4IGF-1R  <response>: The most frequent genetic aberrations in pancreatic cancer is KRAS mutations seen in 60-75 of pancreatic cancers. The tumor-suppressor genes p16, p53, and SMAD4 are inactivated. SMAD4 gene is deleted in 55 of pancreatic tumors. SMAD4 gene inactivation is associated with poorer survival. Overexpression andor aberrant activation of c-Src is also observed. Ref: Harrison, Edition -18, Page-787. 