<prompt> Complications of streptokinase are -Myocardial ruptureJoint painIntracranial bleedAnaphylaxis  <response>: Ref: R. Alagappan Manual for Medicine 4th Edition pg no:188-189 Thrombolytic agents for Myocardial Infarction Agents with fibrin specificity: 1. Alteplase -PA 15 mg IV bolus followed by 0.75 mgkg IV infusion upto 50 mg over 30 minutes then 0.5 mgkg upto 35 mg by IV infusion over 60 minutes maximum dose 100 mg IV over 90 minutes 2. Reteplase r-PA 10 mg IV bolus over 2 minutes followed by another 10 mg IV bolus after 30 minutes. 3. Tenecteplase TNK-tPA 0.5 mgkg IV bolus 60 kg-30 mg, 61-70 kg -35 mg, 71-80 kg-40 mg, 81-90 kg- 45 mg, 90 kg-50 mg Agents without fibrin specificity: 1. Streptokinase - 1.5 million units IV infusion over 60 minutes 2. Urokinase Because of the development of antibodies, patients who were previously treated with strepto- kinase should be given an alternate thrombolytic agent. Contraindications for Thrombolytic Therapy Absolute contraindications: Active bleeding Defective haemostasis Recent major trauma Surgical procedures 10 days Invasive procedures 10 days Neurosurgical procedure 2 months GIgenito-urinary bleeding 6 months StrokeTIA 12 months Prolonged CPR 10 minutes HO CNS tumour, aneurysm, AV malformation Active peptic ulcer Aoic dissection Acute pericarditis Active inflammatory bowel disease Active cavitary lung disease Pregnancy Relative contraindications: Systolic BP 180 mm Hg Diastolic BP 110 mm Hg Bacterial endocarditis Haemorrhagic diabetic retinopathy HO intraocular bleeding Chronic warfarin therapy Severe renal or liver disease Severe menstrual bleeding 