<prompt> Which of the following statements is NOT TRUE about Tacrolimus?It is a macrolide antibioticIt is indicated for the prophylaxis of organ transplant rejectionGlucose intolerance is a well recognized side effectIt can be safely administered with any nephrotoxic drug  <response>: Ans. D It can be safely administered with any nephrotoxic drugRef: KDT 8e p940, 947Tacrolimus is a nephrotoxic agent. Like cyclosporine, it should be administered cautiously in patients receiving other nephrotoxic drugs.In its structure, tacrolimus contains a large macrocyclic ring. It is therefore macrolide in natureIt is an immunosuppressant agent and is used to prevent the rejection of transplanted organ.Nephrotoxicity, hyperglycemia and neurotoxicity are well recognized adverse effects of this drug. 