<prompt> HLA associated with rhaumatoid ahritisHLA-B27HLA-DR4HLA-CW6HLA-B8  <response>: HLA-DR4 DR4 is an HLA-DR serotype that recognizes the DRB104 gene products. The DR4 serogroup is large and has a number of moderate frequency alleles spread over large regions of the worldDR4 is associated with extraaicularrheumatoid ahritis, hydralazine-induced female systemic lupus erythematosus, pemphigoid gestationis, pemphigus foliaceus, obstructive hyperophic cardiomyopathy, IgA nephropathy, shared syndrome-systemic sclerosisrheumatoid ahritis and polymyalgia rheumatica 