<prompt> A patient underwent fine needle aspiration cytology for multinodular goiter. The repo was suspicious for papillary thyroid carcinoma. What is the percentage of risk malignancy in this patient?20573041  <response>: For multinodular goiters, the four largest nodules 1 cm diameter should be biopsied to minimize the risk of missing a malignancy. When FNA cytology is suspicious for papillary thyroid carcinoma or Huhle cell neoplasm, the risk of malignancy is 57. When FNA cytology is a suspicious for follicular carcinoma, the overall risk of malignancy is about 20-25, and higher for patients who are much younger or older than age 50. Most patients with suspicious FNA cytology are advised to have surgery. Ref: Fitzgerald P.A. 2013. Chapter 26. Endocrine Disorders. In M.A. Papadakis, S.J. McPhee, M.W. Rabow, T.G. Berger Eds, CURRENT Medical Diagnosis Treatment 2014. 