<prompt> All of the following are TRUE about hepatocellular carcinoma, EXCEPT:It has a high incidence in East Africa and South east AsiaIts worldwide incidence parallels the prevalence of hepatitis BOver 80 of tumors are surgically resectedLiver transplantation offers the only chance of cure in those with unresectable disease  <response>: Because of multicentricity, bilobar involvement, poal vein invasion, and lymphatic metastasis only 15-20 of hepatocellular carcinoma are resectable Option 1 The highest incidence of disease 10-20 per 100,000 is found in Southeast Asia And tropical africa, and the lowest incidence incidence 1-3 100,000 is found in Australia, Noh america, and Europe Option 2 The geographical distribution of HCC is clearly related to the incidence of hepatitis B virus infection. Option 4 Treatment options for unresectable disease are limited. The liver cannot tolerate high doses of radiation and the disease is not responsive to chemotherapy. Investigative immunotherapy and gene ablation technique have not yet been successful. Liver transplantation offers the only chance of cure for unresectable disease. Ref: Sabiston 18e, Page 1500; CSDT 13e, Page 520,1206; Harrison 17e, Page 580 