<prompt> In which of the following disorders,administration of barbiturates is contraindicated?Anxiety disordersAcute intermittent porphyriaKernicterusRefractory status epilepticus  <response>: Barbiturates induce the rate limiting enzyme amino levulanic acid synthase in porphyrin synthesis. This increased synthesis of prophyrins can precipitate acute attack of AIP Ref: KD Tripathi 8th ed. 