<prompt> Co-factor for phosphofructokinase isMg 2Mn 2Fe 2Zn  <response>: Many of the glycolytic enzymes are sensitive to Mg2. The most impoant effect is due to MgATP2-being a cofactor for a number of these enzymes while other chelation forms are inactive or inhibitory. The means by which Mg2 and Mg2 chelates of adenine nucleotides regulate the most impoant glycolytic enzymes--hexokinase, phosphofructokinase, aldolase, phosphoglycerate kinase, and pyruvate kinaseRef: DM Vasudevan, 7th edition 