<prompt> True about pioglitazone are all except:Metabolized in the liver by CYP3A4Selective agonist for the nuclear peroxisome profilerator activated receptor gammaIt causes transcription of gene for carbohydrate and fat metabolism in the absence of insulinIt should be avoided in a patient with cardio-vascular disease  <response>: Pioglitazone cause activation of genes regulating fatty acid metabolism and lipogenesis in adipose tissue contributes to the insulin sensitizing action. REF.Essential of medical pharmacology K D TRIPATHI 6 Edition, Page No - 270 