<prompt> In pyogenic liver abscess commonest route of spread is -Hematogenous through poal vein.Ascending infection through biliary tractHepatic aeryLocal spread  <response>: Ans is b ie Ascending infection through biliary tract Along with cryptogenic infections, infections from the biliary tree are presently the most common identifiable cause of hepatic abscess. Biliary obstruction results in bile stasis, with the potential for subsequent bacterial colonization, infection and ascension into the liver. This process is ka ascending suppurative cholangitis. The nature of biliary obstruction is mostly related to stone disease or malignancy. In Asia, intrahepatic stones and cholangitis recurrent pyogenic cholangitis are a common cause, whereas in the Western world, malignant obstruction is becoming a more predomiannt factor - Sabiston 