<prompt> The typical Orphan-Annie eye nucleus is described in -Serous cystadenocarcinoma of ovaryRenal cell carcinomaPapillary carcinoma of thyroidSeminoma  <response>: Papillary carcinoma: Accounts for 85 of thyroid malignancy in iodine-deficient areas Most common thyroid cancer in children and in persons exposed to external radiation Most often in women between 30-40 years Excellent prognosis Characteristic nuclear features: Ground glass Orphan Annie nuclei pseudoinclusions Nuclear grooves. Nuclear features are used as diagnostic criteria even in the absence of papillae. Papillary carcinoma: Most commonly spreads through lymphatics. Papillary carcinoma: Metastasize through lymphatics and have an excellent prognosis. 