<prompt> Which type of collagen defect in Good pasture SyndromeType IType IIType IIIType IV  <response>: Type IV 805- CMDT- 08 2073-H17thGood Pasture syndrome - is an uncommon auto immune disease characterized by the presence of circulating auto antibodies targeted against the non collagenous domain of the a3 chain of collagen IV These antibodies initiate an inflammatory destruction of the basement membrane in kidney, glemeruli and lung alveoli, giving rise to proliferative usually RPGN and a necrotizing hemorrhagic interstitial pneumonitisAlports syndrome - is hereditary nephritis, characterised by diffuse glomerular basement membrane thinning. There is defect in the synthesis of type IV collagen because there is a mutation in the gene encoding a- 5 chain of collagen type IV Col 4A5 AIIMS- 06 