<prompt> True about Nephrotic syndrome in a child -Minimal change disease is commonest causeProteinuria of 4 gmm2 hr is characteristicCyclosporin Azathioprine is mainstay of therapyPretreatment biopsy is done in all cases  <response>: Ans. is a i.e., Minimal change is the commonest cause Nephrotic syndrome in children o Most children 90 with nephrotic syndrome have a form of idiopathic nephrotic syndrome. o Causes of idiopathic nephrotic syndrome are - i Minimal change disease 85 ii Mesangial proliferative GN iii FSGS o Infections are a common complication of minimal change disease Nephrotic syndrome o Commonly seen infections are - Spontaneous bacterial peritonitis most common, UTI, Sepsis, pneumonia and cellulitis. o There is increased susceptibility to infections in minimal change disease because of - o Urinary losses of immunoglobulins properidin factor B Malnutrition Defective cell mediated immunity Edemaascites Immunosuppressive therapy o The bacteria most commonly implicated in these cases are Sterptococcus pneumoniae most common and E. coli. 