<prompt> Acetylcholine esterase levels are highly specific for:OmphaloceleGastroschisisOpen spina bifidaSacrococcygeal teratoma  <response>: Ans. c Open spina bifida. Ref. Textbook of obstetrics D C Dutta 6th ed. 112 Pseudocholinesterase in omphalocele Gastroschisis Actual cholinesterase in open spina bifida. specific acetylcholinesterase AChE activity in amniotic fluid was consistently found to be associated withIntrauterine death and Neural tube defects pregnancies with spina bifida.Causes of Increased AFP levels: Wrong gestational age, Open neural tube defects, Multiple pregnancies, IUD, Anterior abdominal wall defects, Renal anomalies, Congenital nephrotic syndrome.Ach esterase has better diagnostic value than AFP in open neural tube defects. 