<prompt> Prophylaxis against spontaneous bacterial peritonitis SBP in case of cirrhosis with ascites is indicated in:Patients with high protein ascitesPrior history of SBPSerum creatinine 1 mgdlChild pugh 8  <response>: The risk factors for SBP are 1.Ascitic fluid protein 1 gdl 2.Variceal hemorrhage 3.Prior episode of SBP Acute variceal bleeding patients need prophylaxis against SBP Drugs used for prophylaxis are: 1.Inj.Ceftriaxone 1 gday 2. Oral. Ofloxacin 400 mgday or Norfloxacin 400 OD Primary prophylaxis is indicated in patients with features of : Ascitic fluid protein 1.5 gdl With at least one of the following 1. Serum creatinine 1.2 mgdl 2. BUN 25 mgdl 3. Serum Na 130 mEqL 4. CTP 9 points with bilirubin 3 mgdl 5. DRug is Norfloxacin 400 mg OD for long time. Ref: AASLD practice guidelines:Hepatology, Vol.49 ,No.6 ,2009. 