<prompt> Use of valproate during pregnancy may result in:Mental retardationRespiratory depressionHydantoin syndromeNeural tube defect  <response>: Valproate crosses the placenta and has been reported to have caused teratogenic effects, including neural tube defects anencephaly, meningomyelocele, and spina bifida in the fetus when the mother received valproate during the first trimester of pregnancy. 