<prompt> Groundglass hepatocytes are seen in which of the following viral hepatitis?Hepatitis AHepatitis BHepatitis CHepatitis D  <response>: Ans. b Hepatitis B Ref Robbins 7th899; TABLE 18-7Robbins 7thB99HBV HISTOLOGY HBV infected hepatocytes may exhibit a cytoplasm packed with spheres and tubules of HBsAg, producing a finely granular eosinophilic cytoplasm GROUNDGLASS HEPATOCYTES.Key Morphologic Features of Viral HepatitisAcute Hepatitis Enlarged. reddened liver: greenish if cholestaticParenchymal changes:Regenerative changes:Hepatocyte injury: swelling ballooning degeneration- hepatocyte proliferationCholestasis: canalicular bile plugs- Sinusoidal cell reactive changesHCV: mild focal fatty change of hepatocytes- Accum of phagocytosed debris in Kupffer cellsHepatocyte necrosis: isolated cells or clusters- Influx of mononuclear cells into sinusoidsCytolysis rupture or apoptosis shrinkage- Portal tracts: Inflammation: pred mononuclearIf severe: bridging necrosis portal-portal, central-central, portal-central- Inflammatory spillover into adj parenchymaLobular disarray: loss of normal architecture- hepatocyte necrosisChronic Hepatitis- Changes shared with acute hepatitis: Hepatocyte injury, necrosis, and regeneration- Sinusoidal cell reactive changes; Portal tracts:- Inflammation: Confined to portal tracts, or Spillover into adjacent parenchyma, with necrosis of hepatocytes interface hepatitis; Bridging inflammation and necrosis- Fibrosis: Portal deposition, or Portal and periportal deposition, or Formation of bridging fibrous septa- HBV: ground-glass hepatocytes ; sanded nuclei- HCV: bile duct epithelial cell proliferation, lymphoid aggregate formation; Cirrhosis: The end-stage outcome 