<prompt> Delayed pubey seen in -Chronic diseaseHypothyroidismTurners syndromeAll  <response>: Ans. is All Delayed pubey o Delayed pubey is defined as failure of development of signs of sexual development by the age of 14 years in boy and breast budding by 13 years of girls. o Etiology of Delayed Pubey : 1. Chronic systemic diseases : Gluten enteropathy, anorexia nervosa. 2. Constitutional delay in growth and pubeal development - most common cause. 3. Hypogonadotropic hypogonadism Low FSH. LH. a CNS causes : Congenital anomalies, intracranial tumors, inflammatory diseases, traumatic lesions of CNS : bPrimary gonadotropin deficiency : Hypopituitarism. c Syndromes with gonadotropin deficiency : Kallmann, Prader-Willi; Laurence-Moon-Biedl-Bardet, Froehlich. dMiscellaneous : Hypothyroidism, hyperprolactinemia. 4. Hypergonadotropic hypogonadism high FSH, LH, Gonadal disorders : a Turner syndrome 45 XO, Noonan syndrome, Klinefelter syndrome 47 XXY. b Anticancer therapy for neoplasms of gonads. c Orchitis d Vanishing testes syndrome. e Testosterone biosynthetic defects. f Infiltration and autoimmune disease of gonads. 