<prompt> In the management of chronic pain, the drug to be used as per first WHO ladder-step is:MorphineAspirinCodineDextropropoxyphene  <response>: Ans. b Aspirin. Ref Bailey Love, 25thpg. 65; 202WHO LADDER FOR ANALGESIA: The main guide to the management of cancer pain is provided by the World Health Organization, which portrays three levels of treatment - the pain stepladder:First ring Simple analgesics - aspirin, paracetamol, NSAIDs, tricyclic drugs or anticonvulsant drugs.Second ring Intermediate strength opioids - codeine, tramadol or dextropropoxyphene;Third ring Strong opioids-morphinepethidine has been with- drawn from the second edition of the World Health Organization guide. Step 3. Severe Pain MorphineOxymorphoneMethadoneLevarpheno!FentanylOxycodone- Nonopioid analgesics- Adjuvants Step 2. Moderate Pain Acet or ASA CodeineHydrocodoneOxycodoneDthydrocodeineTramadol not available with ASA or Acet AdjuvantsStep 1. Mild PainAspirin ASAAcetaminophen AcetNonsteroidal anti-inflammatory drugs NSAIDs- AdjuvantsAdjuvants refers either to medications that are coadministered to manage an adverse effect of an opioid or to so-called adjuvants analgesics that are added to enhance analgesia. 