<prompt> Fredrickson;s type II hyperlipoproteinemia is due to excess amount ofVLDL remnatsVLDLFloating LDLHDL  <response>: Type II: Familial Hypercholesterolaemia FHC: A common disorder which has been extensively investigated.The disease is characterised by:Hyper b-lipoproteinaemia LDL Associated with increased total cholesterol VLDL may be raised, hence total TG may be high.But plasma usually remains clear.Inheritance: Autosomal dominant; Frequency--0.2 percentEnzyme deficiency metabolic defect: There is no enzyme deficiency. Metabolic defects are:An increased synthesis of apo-B Defective catabolism of LDL. Deficiency of LDL receptors in fibroblasts demonstrated.Clinical features: Xanthomas of tendinous and tuberous type have been describedCorneal arcusOccasionally xanthelasma. Clinically most impoantis the increased incidence of atherosclerosis andpremature cardiovascular diseases.Note: Type-II Pattern can develop as a result of hypothyroidismsecondary hyper or lipoproteinemia.Ref: M.N. Chatterjee - Textbook of Biochemistry, 8th edition, page no: 451 