<prompt> Hashimoto;s thyroiditis - True are all exceptFollicular destructionIncrease in lymphocytesOncocytic metaplasiaOrphan Annie eye nuclei  <response>: Cause of Hashimoto thyroiditis,is autoimmune-mediated destruction of thyrocytes. A complex immunologic phenomenon results in the formation of immunecomplexes and complement in the basement membrane of follicular cells. These cellular reactions ultimately result in the infiltration of lymphocytes and resultant fibrosis, which decreases the number and efficiency of individual follicles. Thus leading to hypothyroidism Huhle cell oncocytes changes are seen in Hasimotos thyroiditis. Orphan annie eye nuclei are seen in papillary carcinoma thyroid. Source Sabiston 20th edition Pg : 891 