<prompt> Mucopolysacchidosis, which is a lysosomal storage disease, occurs due to abnormality in:Hydrolase enzymeDehydorgenase enzymeLipase enzymePhosphatase  <response>: Ans: a. Hydrolase enzyme Ref Harper 30th638-39, 29th589, 599, 600; Lippincott 6th163-64JThe mucopolysaccharidoses are hereditary diseases caused by a deficiency of any one of the lysosomal hydrolases normally involved in the degradation of heparan sulfate andor dermatan sulfateThey are progressive disorders characterized by accumulation of glycosaminoglycans in various tissues, causing a range of symptoms, such as skeletal and extracellular matrix deformities, and mental retardation.Children who are homozygous for any one of these diseases are apparently normal at bih, then gradually deteriorate. In severe cases, death occurs in childhood.Diagnosis is confirmed by measuring the patients cellular level of the lysosomal hydrolases. Bone marrow and cord blood transplants have been used to treat Hurler and Hunter syndrome 