<prompt> Most common cause of death in primary amyloidosis is?Respiratory failureCardiac failureRenal failureSepticemia  <response>: ANSWER: B Cardiac failureREF: Harrisons Internal Medicine 17th edition chapter 324. AmyloidosisThe kidneys are the most frequently affected organ 80, Renal amyloidosis is usually manifested by proteinuria, which is often in the nephrotic range and associated with significant hypoalbuminemia and edema or anasarca; rarely, tubular rather than glomerular deposition of amyloid can produce azotemia without significant proteinuria. Cardiac symptoms are the second most common presentation 40, but cardiac dysfunction is associated with death in 75 of patients. 