<prompt> First change of improvement noted after iron therapy is initiated:Decreased irritabilityReticulocytosisIncrease in serum iron levelsReplenishment of iron stores  <response>: RESPONSE TO TREATMENT IN IRON DEFICIENCY ANEMIA: Time after Iron administration Response 12-24 hours Decreased irritability, increased appetite 48-72 hours Reticulocytosis, peaks at 5-7 days post treatment 4-30 days Increase in Hb level best measure 1-3 months Repletion of stores 