<prompt> Nitroglycerine is effective when adminsted sublingually because it isnon ionized and lipid solubleionized and lipid solublenon ionized and water insolubleionized and water soluble  <response>: Nitroglycerin is effective when retained sublingually because it is non ionized and has very high lipid solubility.Thus,the drug is absorbed very rapidly. Ref-Goodman Gillman12the p124,125 