<prompt> True statement regarding mechanism of action of sulfonylureas is:-Increase peripheral utilization of glucoseReduce hepatic glucose outputAct on SUR1 receptors on pancreatic beta cell membraneIncrease transcription of genes regulating glucose metabolism  <response>: SULFONYLUREAS These bind to sulfonuyl urea receptors 1 SUR1 on b cells of pancreas and inhibit ATP sensitive K channels. This cause depolarization of b cells resulting in release of insulin. These drugs are effective only if 30 or more of the b cells in the pancreas are available. Major limitation of these drugs is like insulin, can also cause hypoglycemia. 