<prompt> DOC in allergic bronchopulmonary aspergillosis ABPA:PrednisoloneIV Amphotercin BIV Phenramine maleateFluconazole  <response>: Ans: a Prednisolone Ref: Harrison, 16th ed, p. 1189; 17th ed, p. 1260, Table 197-2Drug of choice for ABPA is prednisolone. According to new recommendadation 17th ed, Harrison,Table 197-2 drug of choice is ITRACONAZOLETreatment of aspergillus infectionFungus ball of the lung - Surgical resectionABPA- short course of Glucocorticoids prednisoloneInvasive Aspergillosis-voriconazole, liposomal or conventional amphotercin BMajor diagnostic criteria for ABPA:Secondary diagnostic criteria1. Clinical history of asthma1. History of brownish plugs in sputum2. Pulmonary infiltrates transient or fixed2. Culture of A. fumigatus from sputum3. Peripheral eosinophilia 1000uL3. Late skin reactivity to aspergillus antigen4. Immediate skin reactivity to aspergillus antigen.4. Elevated IgE and IgG class antibodies specific for A. fumigatus.5. Serum precipitates to A. fumigatus6. Elevated serum IgE levels.7. Central proximal bronchiectasisIn recent papers lot of questions are asked regarding the antimicrobial of choice. Therefore we have listed some of the important ones.Gonococcal infection- CeftriaxoneClostridium- Penicillin IV ClindamycinDiphtheria- ErythromycinListeria- IV Ampicillin or PenicillinKlebsiella- CarbepenemCampylobacter- ErythromycinYersenia pestis- StreptomycinPertussis- ErythromycinBrucella- StreptomycinChlamydia- AzithromycinMycoplasma- Erythromycin 