<prompt> XDR-TB is defined as Resistance to -INH plus rifampicinFluoroquinolones plus INH plus amikacinFluoroquinolones plus rifampicin plus kanamycinFluoroquinolones plus INH plus rifampicin plus amikacin  <response>: Ans. is d i.e., Fluoroquinolones plus INH plus rifampicin plus amikacin Treatment of multidrug resistance MDR TBo MDR-TB is defined as resistance to at least both INH and rifampicin. Previously it was classified as Category IV under DOTS DOTS-PLUS.o The treatment is given in two phases, the intestive phase IP and the continuation phase CP. The total duration of treatment for regimen for MDR-TB is 24-27 months, depending on the IP duration.o Treatment regimen comprises :-i Intensive phase 6-9 months: Six drugs: Kanamycin Km, levofloxacin Lvx, ethionamide Eto, pyrazinamide Z, ethambutol E, and cycloserine Cs.ii Continuation phase 18 months : Four drugs: Levofloxaxcin, ethionamide, ethambutol and cycloserineo Total duration of treatment is 24-27 months.Treatment of extensive drug resistance XDR TBo XDR-TB is defined as resistance to any fluoroquinolone and at least one of the following three second-line drugs capreomycin, kanamycin, amikacin, in addition to multidrug resistanceo The Regimen for XDR-TB would be of 24-30 months duration, with 6-12 months Intensive Phase IP and 18 months Continuation Phase CPo Regimen isi Intensive phase 6-12 months: Seven drugs : Capreomycin, PAS, moxifloxacin, high dose INH, clofazimine, Linezolid, amoxyclav.ii Continuation phase 18 months: Six drugs: PAS, moxifloxacin, high dose INH, clofazimine, linezolid, amoxyclav. 