<prompt> Peripheral neuritis induced by isoniazid is prevented by giving which vitamin along with it?Vitamin B1Vitamin B6Vitamin B3Vitamin B12  <response>: Ans. is b i.e., Vitamin B6 Isoniazid induced peripheral neuritis neuropathy Peripheral neuritis is a well documented adverse effect of INH, which is also the most important dose dependant toxic effect. Peripheral neuropathy is observed in 10 to 20 of patients given dosages greater than 5 mgkgd, but it is infrequently seen with the standard 300-mg adult dose. Peripheral neuropathy is more likely to occur in slow acetylators and patients with predisposing conditions such as malnutrition, alcoholism, diabetes, AIDS, and uremia. Neuropathy is due to a relative pyridoxine deficiency. It is due to interference with production of active co - enzyme PLP Pyridoxal phosphate from pyridoxine. It is readily reversed by administration of pyridoxine in a dosage as low as 10 mgd. 