<prompt> Which of the following drugs act by inhibiting granulocyte migration?ColchicineMontelukastCromoglycateAllopurinol  <response>: Ans A ColchicineRef: Goodman and Gilman 13th702-703Colchicine is more effective and faster acting than NSAIDs but is used rarely due to its high toxicity.It acts by inhibiting granulocyte migration into the in- flamed joint.It causes metaphase arrest other drugs causing meta- phase arrest are vinca alkaloids, ixabepilone and taxanes.Most common and dose limiting toxicity is diarrhea.It can also cause kidney damage, myopathy and bone marrow depression. 