<prompt> Acute hematogenous osteomyelitis is often diagnosed by isolation of the organism from the blood and is caused most often byProteus mirabilisStreptococcus faecalisStaphylococcus epidermidisS. aureus  <response>: Staphylococcus aureus is implicated in the majority of cases of acute osteomyelitis, which affects children most often. A superficial staphylococcal lesion frequently precedes the development of bone infection. In the pre-antibiotic era, S. pneumoniae was a common cause of acute osteomyelitis. Mycobacterium tuberculosis and Gram-negative organisms are implicated less frequently in this infection. 