<prompt> In which of the following pathologic calcification the normal calcium metabolism is seenMetastatic calcificationDystrophic calcificationIonotropic calcificationRadiation calcification  <response>: B. i.e. Dystrophic calcification 26- 27- Basic pathology 8thDifferences between Dystrophic and Metastatic calcificationFeatureDystrophicMetastatic1. DefinitionDeposition of calcium salts in dead and degenerated tissueDeposits of calcium salts in normal tissues2. Calcium metabolismNormalRearranged3. Serum calcium levelNormalHypercalcemia4. CausesNecrosis Caseous - Tuberculosis Liquefactive - Chronic abscessFat - Acute pancreatitisTraumatic fat necrosis -Breast1. Increased secretion of parathyroidhormone PTHHyperparathyroidism, due to adenoma, hyperplasia2. Destruction of bone tissueMultiple myelomas, leukemia, Breast cancer, Paget disease, prolonged immobilization3. Vitamin-D related disorders Hypervitaminosis - D Idiopathic hypercalcemia of infancy Williams syndrome4. Renal failure secondary hyperparathyroidism less common Milk-Alkali syndrome Aluminum intoxication5. PathogenesisAkin to the formation of normal hydroxyapatite involving phases of initiation and propagationFavoured by relatively high pH alkaline at certain sites eg. In lungs, stomach, blood vessels and cornea 