<prompt> In primary immune deficiency, the following plasma protein fraction is reduced -alpha-1 globulinAlpha 2 globulinBeta globulinGamma-globulin  <response>: Hypogammaglobulinemia is characterized by a decrease in the g component. It is seen in congenital immune deficiency syndromes or in association with diseases such as nephrotic syndrome, chronic lymphocytic leukemia, and coicosteroid treatment . Ref - Davidson 23rd edition pg 1063b 