<prompt> What is the impact on fetus in case of use of Indomethacin in utero in third trimester?Patent ductus aeriosusEarly closure of ductus aeriosusVentricular septal defectAtrial septal defect  <response>: Prostaglandins helps to keep ductus aeriosus open. Indomethacin inhibits prostaglandins levels So, closure of ductus aeriosus DOC for PDA 