<prompt> All the following statements about Epinephrine used as an adjuvant are true ExceptExtends block duration, limits systemic uptake, supplements analgesic effect, and acts as an indicator of intravascular injectionCan cause toxicity to peripheral nerves in patients with diabetes or chemotherapyLocal anaesthetics and epinephrine have no effect on peripheral nerve blood flowCan aggravate local anaesthetic-induced neuraxial or peripheral nerve injury  <response>: Local anesthetics and epinephrine significantly reduce peripheral nerve blood flow. Low-dosage epidural usage results in uptake and decreases systemic vascular resistance and increases cardiac output. 