<prompt> Alpha1 antitrypsin gene is on which chromosome?Chr 11Chr12Chr 13Chr 14  <response>: d. Chr 14Ref: Nelson 20e p 1941, 2053a1-Antitrypsin deficiencyIt is caused by mutation in SERPINA1 gene chr 14q, which has autosomal recessive inheritance.a1-Antitrypsin, a protease inhibitor synthesized by liver, protects lung tissue from destruction by neutrophil elastase;Most common allele of protease inhibitor Pi system is M the normal phenotype is PiMM. 