<prompt> Most effective treatment for severe malaria is:AesunateChloroquineQuininePrimaquine  <response>: CLASSIFICATION 1.4-Aminoquinolines: Chloroquine, Amodiaquine, Piperaquine. 2.Quinoline-methanol :Mefloquine. 3.Cinchona alkaloid :Quinine, Quinidine 4.Biguanides :Proguanil Chloroguanide Chlorproguanil 5. Diaminopyrimidines Pyrimethamine 6. 8-Aminoquinoline :Primaquine, Bulaquine 7.Sulfonamides and sulfone: Sulfadoxine Sulfamethopyrazine Dapsone 8. Tetracyclines:Tetracycline, Doxycycline 9. Sesquiterpine lactones:Aesunate, Aemether, Aeether 1 0. Amino alcohols:Halofantrine, Lumefantrine 1 1 . Mannich base:Pyronaridine 1 2. Naphthoquinone:Atovaquone 1. Aesunate-sulfadoxine pyrimethamine AS5P This ACT has been adopted as the first line drug for falciparum malaria in chloroquineresistant areas under the ;National antimalaria drug policy; of India, and has replaced chloroquine in 73 districts. However, this does not imply that it is the most effectivebest ACT, because it is not effective against multidrugresistant strains which are nonresponsive to SP. Moreover, no comparative evaluation of this regimen against ASMQ or aemether lumefantrine, etc. has been done to establish the relative efficacy tolerability. 2. Aesunate-mefloquine ASMQ It has been extensively used in Thailand, Myanmar and several other countries; found to be highly effective, well tolerated and is now the first line treatment for uncomplicated falciparum malaria in Southeast Asia. Many areas in the far East already have mefloquine-resistant P. falciparum. By combining with aesunate, fuher spread of mefloquine-resistance has been prevented ESSENTIALS OF MEDICAL PHARMACOLOGY K.D.TRIPATHI SIXTH EDITION PAGE NO:781,795 