<prompt> A female patient presented with a firm mass of 2 x 2 ems in the upper outer quadrant of the breast. She gives a family history of ovarian carcinoma. The investigation that needs to be done to assess for mutation is -p53BRCA-2Her 2Neu geneC-myc gene  <response>: In women with hereditary breast - ovarian cancer, two susceptibility loci have been identified:BRCA -1 located on chromosome 17 andBRCA - 2 located on chromosome 13About 25 of familial cancers or around 3 of all breast cancer can be attributed to two highly penetrant autosomal dominant genes BRCA1 and BRCA2 Coming to the questionThis woman is suffering from familial breast carcinoma as family history positive for ovarian cancerThe most common gene associated with familial breast cancer is BRCA-1 52 followed by BRCA-2 32 of all familial cancers.BRAC-1 and BRAC-2 are associated with ovarian cancer, so a family history of ovarian carcinoma may be positive. RememberThe most common gene involved in famiilial breast cancer BRCA-1The most common gene involved in sporadic breast cancer p53Most common gene involved overall Hereditary plus sporadic p53The maximum increase in susceptibility to breast cancer is seen with p53 mutation 90 whether it is sporadic or Hereditary. 