<prompt> Large cells with plant like appearance with perinuclear halo is seen in which type of renal cell carcinoma?Granular cell carcinomaAngiosarcomaChromophobicClear cell carcinoma  <response>: Ans. is c i.e., Chromophobic Types of renal cell carcinoma Important histological types of renal-cell carcinoma are1 Clear cell carcinoma It is the most common type of renal cancer accounting for about 70 to 80 of the renal cell cancer. They are so named because they are made up to cells with clear or granular cytoplasm and are nonpapillary. They occur as solitary unilateral lesions. It arises from proximal tubular epithelium.2 Papillary Carcinoma It accounts for 10 to 15 of renal cancers. It is characterized by papillary growth pattern. It arises from distal convoluted tubule. It can be multifocal and bilateral. These are most common type of renal cancer in patients who develop dialysis associated cystic disease. Papillary carcinoma also occurs in two forms hereditary and sporadic.3 Chromophobe oncocytic renal cell carcinoma These tumors arise from intercalated cells of cortical collecting ducts. The cells have pale eosinophilic cytoplasm with perinuclear halo with a plant cell appearance. Electron microscopic finding consisting of numerous 150-300 nm microvesicles is the single most distinctive and defining feature of chromophobe cell carcinoma.4 Collecting duct Bellini duct carcinoma It is the least common type of RCC. It arises from medullary collecting duct. Cells have prominent fibrotic stroma. 