<prompt> In rheumatic hea disease, infective endocarditis is detected by echocardiogram and the largest vegetations seen are due to -Streptococcus viridansStaphylococcus aureusCandida albicansSalmonella typhi  <response>: Ref: R Alagappan - Manual of Practical Medicine 4th Edition.pg no:161-162 Acute infective endocarditis: Caused by highly virulent organisms mainly S. aureus 20-30, seeding a previously normal valve 2D Echo The smallest size of vegetation that can be picked up by echo is 2 mm. Transoesophageal echocardiography is more sensitive in detecting vegetations in the aoic valve 90 and mitral valve 100 than transthoracic echocardiography 