<prompt> A 70 year old male presented with excessive fatigue, fever bleeding from gums while brushing. OE- he has splenomegaly. CBC shows marked pancytopenia with presence of blasts. t15;17q22;q12 cytogenetic rearrangement is found in this patient. Which of the following agents will you use in management of this patient?AcyclovirDaunorubicinRituximabTretinoin  <response>: Given scenario suggests the diagnosis of Acute promyelocytic leukemia APML ATRA all trans retinoic acid is used in management of APML. Induces the differentiation of leukemic cells bearing translocation , where disruption of the RARA gene encoding a retinoid acid receptor occurs. Decreases the frequency of DIC SE: APL differentiation syndrome- Occurring within the first 3 weeks of treatment, characterized by fever, dyspnea, chest pain, pleural and pericardial effusions, and hypoxemia Rx: Glucocoicoids, chemotherapy, andor suppoive measures Cytarabine and daunorubicin increases risk of disseminated intravascular coagulation DIC Rituximab is a monoclonal antibody against CD20 used in autoimmune and malignant diseases 