<prompt> The most common site of esophageal adenocarcinoma is:Upper 13rdMiddle 13rdLower 13rdUpper 23rd  <response>: Answer is C Lower 13rd The most common site of adenocarcinoma esophagus is the lower 13rd of esophagus Esophageal Adenocarcinoma invariably arises from Barrets esophagus Barrets ulcer which is characteristically located in the distal esophagus around the gastroesophageal junction. 