<prompt> The antibody in SLE with decreased risk of nephritis?Anti SS-aAnti ds dnaAnti smithAnti histone  <response>: Autoantibodies in Systemic Lupus Erythematosus SLE Antibody Prevalence, Antigen Recognized Clinical Utility Antinuclear antibodies 98 Multiple nuclear Best screening test; repeated negative tests make SLE unlikely Anti-dsDNA 70 DNA double-stranded High titers are SLE-specific and in some patients correlate with disease activity, nephritis, vasculitis Anti-Sm 25 Protein complexed to 6 species of nuclear U1 RNA Specific for SLE; no definite clinical correlations; most patients also have anti-RNP; more common in blacks and Asians than whites Antihistone 70 Histones associated with DNA in the nucleosome, chromatin More frequent in drug-induced lupus than in SLE Anti-Ro SS-A 30 Protein complexed to hY RNA, primarily 60 kDa and 52 kDa Not specific for SLE; associated with sicca syndrome, predisposes to subacute cutaneous lupus, and to neonatal lupus with congenital hea block; associated with decreased risk for nephritis Anti-La SS-B 10 47-kDa protein complexed to hY RNA Usually associated with anti-Ro; associated with decreased risk for nephritis Ref: Harrison;s Principles of Internal Medicine; 20th edition; Chapter 378 Systemic Lupus Erythematosus; Page no: 2125 