<prompt> Which of the following statement regarding first order kinetics is true?It is independent of plasma concentrationTl2 of the drug increases with doseClearance of the drug decreases with doseA constant propoion of plasma concentration is eliminated  <response>: According to first order kinetics of elimination the rate of elimination of a drug is directly propotional to the drug concentration. Clearence of the drug remains constant and a constant fraction of drug is eliminated in unit time. Ref: Essentials of Medical Pharmacology By KD Tripathi, 5th Edition, Page 27-8 