<prompt> Most common mitochondrial enzyme for metabolism detoxification reaction is -CYP 3A4CYP 1A2CYP 2A6CYP 2B6  <response>: Ans. is a i.e., CYP 3A4 Subtypes of cytochrome P-450o Depending upon the extent of amino acid sequence homology, the cytochrome PASO CYP isoenzymes are grouped into families designated by capital letters A, B, C....o Individual isoenzymes are again alloted numerals 1, 2, 3 ....o Examples are CYP1A2, 2A6, 2B6, 2C8, 3A43A5.o In human beings, only a few members of three isoenzyme families carry out metabolism of most of the drugs,o Cyp 3 A 45 carryout biotransformation of largest number nearly 50 of drugs.Important inducers of CYP 3A43A5o Barbiturateso Carbamazepineo Glucocorticoidso Phenytoino Rifampino Pioglitazoneo Macroide antibiotics 