<prompt> Growth hormone has its effect on growth through-DirectlyIGF -1ThyroxineIntranuclear receptors  <response>: Ans. is b i.e., IGF -1 o GH has two major functions:- The growth of skeletal system The growth is mediated by somatomedins IGF. Increased deposition of cartilage including chondroitin sulfate and bone with increased proliferation of chondrocytes and osteocytes. Metabolic effects- most of the metabolic effects are due to the direct action of GH. These include gluconeogenesis, decreased peripheral utilization of glucose decreased uptake, lipolysis and anabolic effect on proteins. 