<prompt> A 55-ycar-old woman presents with progressively deepening jaundicc, uncontrollable pruritus, pain in the abdomen right upper quadrant and yellow coloured urine. Investigations revealed -Viral hepatitisCirrhosis of liverCarcinoma of head of the pancreasHepatocellular carcinoma  <response>: DAVIDSON;S principles and practice of medicine 22nd edition. around 60 of tumours arising from head of pancreas and involvement of common bile duct result in the development of obstructive jaundice, often with severe pruritis.Advanced stage present with central abdominal pain ,weight loss,pain radiates from upper abdomen from back. 