<prompt> Which part of the IgE antibody is responsible for binding to mast cells and basophils?Light chainImmunoglobulin foldFc regionComplement binding site  <response>: Ans is c i.e., Fc region IgE primes the IgE-mediated allergic response by binding to Fc receptors found on the surface of mast cells and basophils. Fc receptors are also found on eosinophils, monocytes, macrophages and platelets in humans. There are two types of Fee receptors:A. FceRI type I Fee receptor, the high-affinity IgE receptor.B. FceRII type II Fee receptor, also known as CD23, the low-affinity IgE receptor. IgE can upregulate the expression of both types of Fee receptors. FceRI is expressed on mast cells, basophils, and the antigen-presenting dendritic cells. Binding of antigens to IgE already bound by the FceRI on mast cells causes cross-linking of the bound IgE and the aggregation of the underlying FceRI, leading to the degranulation and the release of mediators from the cells. 