<prompt> HIV mostly affects which cells?CD4 cellsCD 8 cellsT cellsPlasma cells  <response>: harshmohan textbook of pathology 7th edition. the pathogenesis of HIV infection is largely related to the depletion of CD4 T cells resulting in preformed immunosuppression .Selective tropism for CD4 molecule receptors, gp 120 envelope glycoprotein of HIV has selective tropism for the cells containing CD 4 molecules on their surface,most impoantly CD4T cells 