<prompt> Submicroscopic deletions of any size can be detected by?Multiplex ligation-Dependent probe amplification MLPASouthern blottingCytogenomic array technologyChromosome painting  <response>: Ans. a Multiplex ligation-Dependent probe amplification MLPARef: Robbins 9thpg 177; 8thpg 179Multiplex Ligation-Dependent Probe Amplification MLPA: MLPA is a technique which mixes DNA hybridization, DNA ligation, and PCR amplification to detect deletions and duplications of any size, including anomalies that are too large to be detected by PCR and too small to be identified by FISH. 