<prompt> Risk factors for coronary aery diseaseHigh HDLLow HDLIncreased homocysteine levelsDecreased fibrinogen levels  <response>: Ref Harrison 19 th ed pg 1579 The major risk factors for atherosclerosis high levels of plasma low-density lipoprotein , low plasma high-density lipoprotein , cigarette smoking, hypeension, and diabetes mellitus disturb the normal functions of the vascular endothelium. 