<prompt> Which of the following statements about Pancreatic Carcinoma is not true :Mutation in P53 gene is associated in 75 of casesHereditary Pancreatitis significantly increases the riskMedian survival in locally advanced stage III disease is 3- 6 monthsFive year survival after curative pancreaticoduodenectomy is 15 - 20  <response>: Answer is C Median Survival in locally advanced stage III disease is 3- 6 months Median survival of locally advanced Stage III disease is 6-10 months and not 3-6 months. Median survival of 3-6 months is a feature of Metastatic Stage IV disease. Median survival in locally advanced disease stage III is 6 - 10 months Metastatic disease stage IV is associated with a median survival of 3 - 6 months. Stage III locally advanced disease is associated with a median survival of 6 - 10 months Clinical Radiological Criteria Median Survival Resectable Disease Stage I and Stage II 15 - 20 months Locally Advanced Disease Stage III 6 - 10 months Metastatic Disease Stage IV 3 - 6 months p53 mutation is seen in 75 of cases of Pancreatic cancer Gene Pancreatic Cancer Colorectal Cancer P16 95 0 K - ras 90 50 P53 75 60 DPC4 55 15 BRCA 2 7 ? Taken from Gastrointestinal and Liver disease by Feldman 81 1312 Hereditary Pancreatitis significantly increases the risk of Pancreatic Cancer One of the most impoant genetic factors in pancreatic carcinoma is hereditary pancreatitis. Affected patients have an abnormal trypsin gene that is transmitted as an autosomal dominant trait. Their risk of development of pancreatic cancer by age 70 years is estimated at 40 - Gastrointestinal and Liver Diseases by Feldman 8th 1309 Five Year Survival after curative Pancreaticoduodenectomy approaches 15 -20. Overall 5-year survival rate with pancreatic cancer is 5 5 - year survival rate for patients undergoing curative tumor resection pancreaticoduodenectomy is 15 - 20 Note Only 10 of pancreatic cancers are diagnosed at on early stage when radical resection with curative intent can be performed. - Pathophysiology of Disease Lange 5th 454 