<prompt> Type I hypersensitivity, the mediator is -IgEIgDIgMIgC  <response>: Type I hypersensitivity reaction is IgE dependent. Cytotoxic IgE antibodies are fixed on the surface of tissue cells mast cells and basophils in sensitized individuals. The antigen combines with the cell fixed antibody, leading to release of pharmacologically active substance that produces the clinical reaction. Reference : Anathanarayan panikers 9th edition, pg: 162 p 