<prompt> Which pair of organs is involved in Goodpastures syndrome: March 2010Kidney and intestineKidney and heaKidney and lungsKidney and liver  <response>: Ans. C: Kidney and lungs Goodpastures syndrome is a rare disease that can affect the lungs and kidneys. Also called anti-glomerular basement antibody disease, it is an autoimmune disease in which kidney and lung injury are caused by circulating autoantibodies against the noncollagenous domain of the alpha3 chain of collagen IV. The antibodies initiate inflammatory destruction of the basement membrane in the renal glomeruli and pulmonary alveoli, giving rise to a proliferative, usually rapidly progressive glomerulonephritis and a necrotizing hemorrhagic interstitial pneumonitis. 