<prompt> Most common cause of death in menkes disease is-Cardiac ruptureDiaphragmatic paralysisLaryngospasmCyano-methemoglobinemia  <response>: Ans. is a i.e., Cardiac rupture o Children with this disease often die within 5 years because of dissecting aneurysms or cardiac rupture.Menkes kinky hair syndromeo An X-1 inked metabolic disturbance of copper metabolism characterized by Mental retardation, hypocupremia, and decreased circulating ceruloplasmin.o Caused by mutations in the copper-transporting A TP7A gene.o Children with this disease often die within 5 years because of dissecting aneurysms or cardiac rupture. 