<prompt> Familial polyposis coli is associated with following genetic defect?MLH1MSH2APCRET  <response>: Ans is ;c i.e., APC Familial adenomatous polyposis FAP syndrome familial polyposis coli is caused by mutation in adenomatous polyposis coli geneAPC located on long arm of chromosome 5 5q21. Risk of malignancy is 100, i.e. all patients develop colorectal carcinoma if left untreated. 