<prompt> Not true about gyneocamastia isCan be drug inducedKlinefelters syndromeSeen in cryptoorchidismNone of the above  <response>: Gynaecomastia is hyperophy of male breast more than usual due to increase in ductal epithelial and connective tissue stromal elements often attaining features of female breast. It can be unilateral or bilateral. Bilateral can be symmetrical or asymmetrical. Etiology is Oestrogen excess--increased estradiol secretion due to testicular tumour Leydig cell or nontesticular tumours from adrenal coex, lung, liver; hypehyroidism increases conversion of androgen to estrogen, liver diseases, oestrogen therapy for prostate cancer. Androgen deficiency--aging, KlinefeltersKallmann syndromes, eunuch, ACTH defi ciency. Secondary testicular failure--cryptorchidism, orchitis, trauma, CRF, etc. Drugs 25:Increases estrogen activity digitalis, anabolic steroidestrogen synthesis reserpine, theophylline, frusemide. Inhibition of testosterone synthesis--cimetidine, phenytoin, spironolactone. Ref; page no; 527 5th edition of SRB;S manual of Surgery. 