<prompt> All have effects on oxygen-hemoglobin dissociation curve except:2,3-DPGCO, pressureChloride ionAcidosis  <response>: Ans: C Chloride.. Ref: Fetal Hb, Hypothermia, Hypocarbia alkalosis cause left shift of the curve. Right Shift cause more O2 delivery to tissue.Hb-O2 dissociation curveLeft ShiftingRight Shifting 2, 3- BPG 2, 3-BPG Alkalosis Acidosis Hypothermia Hyperthermia Foetal Hb High altitude Hypocarbia Excercise Stored blood Hypercarbia Hb Chesapeake Anaemia Hb Ranier Sickle cell anaemia HbM Diabetic Ketoacidosis Thyroid hormone Growth hormone Androgen Diseases causing chronic hypoxiaNote: Mb-O2 dissociation curve lies left to of Hb-O2 dissociation curveFactor Affecting Affinity of Hb for O2 - Ganong 667-69Three important condition affecting Hb-O2 dissociation curve - pH, temperature concentration of 2, 3-BPG. A rise in temperature or fall in pH shift the curve to right. 2,3-BPG is very plentiful in red cell. It is formed from 3-phosphoglycoraldehyde 3-PGA, which is a product of glycolysis via the Embden-Meyerhof pathway. Because acidosis inhibit glycolysis., 2,3-BPG concentration falls when pH is low. Thyroid hormone, Growth hormone, androgen increase the concentration of 2, 3-BPG the P50 The affinity of foetal Hb HbF for O2, which is greater than that of adult Hb HbA, shifts the curve to left,Excercise has been reported to produce an increase in 2,3- BPG within 60 minutes .although the rise may not occur in trained athletes. The P50 is also increased during excercise. Ascend to high4 altitude trigger a substantial rise in 2,3-BPG concentration. The rise in 2, 3-BPG, which has a half-like of 6 hours, is secondary to the rise in blood pH. 2,3-BPG level drops to normal on return to sea level.Certain Hb like sickle cell anaemia shift the O2 dissociation cu rve to right- Kumar Clark 4th357 6th430HbM O2 affinity is much lower than normal HbA while O2. affinity of Hb Chesapeake Rainier is more - Chatterjea Shinde 7th 149Because Mb-O2 dissociation curve lies left5 of Hb-O2 dissociation curve, it takes up O2 from Hb in the blood- Ganong 22nd669 