<prompt> The highest malignant potential is seen in:Crohns diseaseUlcerative colitisFamilial polyposisInfantile polyp  <response>: Colorectal cancer develops in 100 of untreated FAP patients often before the age of 30. Familial adenomatous polyposis FAP Autosomal dominant Numerous colorectal adenomas by teenage years. Mutation of adenomatous polyposis coli gene APC. At least 100 polyps is necessary for diagnosis of classic FAP, High risk of causing colorectal cancer, Prophylactic colectomy is standard therapy Etiology Molecular defect Target gene Transmission Familial adenomatous polyposis APCWNT pathway APC Autosomal dominant Hereditary nonpolyposis colorectal cancer DNA mismatch repair MSH2, MLH1 Autosomal dominant Sporadic colon cancer APCWNT pathway APC None Sporadic colon cancer DNA mismatch repair MSH2, MLH1 None 