<prompt> Neprilysin inhibitor is:CarperitideNesiritideSacubitrilConivaptan  <response>: Ref. KDT. Page. 889Neprilysin, also known as membrane metallo-endopeptidase MME SacubitrilSacubitrils active metabolite, LBQ657 inhibits neprilysin, a neutral endopeptidase that would typically cleave natiuretic peptides, which includes: atrial natriuretic peptide ANP, brain natriuretic peptide BNP, and c-type natriuretic peptide CNPThe half life of sacubitril is 1.1 to 3.6 hoursThe most common adverse reactions are hypotension, hyperkalemia, coughUsed in combination with valsartan to reduce the risk of cardiovascular events in patients with chronic heart failure NYHA Class II-IV and reduced ejection fraction. 