<prompt> Bortezomib drug used in -Multiple myelomaRCCLiver cell carcinomaPancreatic carcinoma  <response>: Ans. is a i.e., Multiple myeloma Uses of bortezomib:o The prime indication of bortezomib is multiple myeloma, both for first line combined therapy as well as for replapsed disease.o It is also used for refractory mantle cell lymphoma.Note: The most prominent adverse effect of bortezomibis peripheral neuropathy. Others are diarrhea, fatigue, bone marrow depression especially thrombocytopenia. 