<prompt> Methotrexate for treatment of ectopic pregnancy is administered by which route and at what dose?Orally, 100 mgm2Intravaginally, 100 mgm2Intramuscularly, 50 mgm2Subcutaneously, 50 mgm2  <response>: Methotrexate Therapy for Primary Treatment of Ectopic Pregnancy: Regimen Surveillance Single Dose Methotrexate, 50 mgm2 IM Measure b-hCG levels days 4 and 7: If difference 15 percent, repeat weekly until undetectable If differences 15 percent between day 4 and 7 levels, repeat methotrexate dose and begin from day 1 If fetal cardiac activity present day 7, repeat methotrexate dose, begin from day 1 Surgical treatment if b-hCG levels not decreasing or Fetal cardiac activity persists after three doses methotrexate Multiple dose Methotrexate, 50 mgm2 IM, days 0,4 Variable dose up to four doses: Methotrexate, 1 mg kg IM, days 1,3,5,7 Leucovorin, 0.1 mgkg IG, days 2,4,6,8 Follow up for single dose regimen Measure b hCG levels day 1,3,5, and 7. Continue alternate - day injections until b hCG levels decreases 15 in 48 hours or four doses of methotrexate. Then, weekly b-hCG until undetectable. 