<prompt> Statins are given at night because ?HMG-CoA reductase activity is maximum in midnightStatins are maximally absorbed in nightStatins have more potency in nightConvenient for patient to remember  <response>: Ans. isa i.e., HMG-CoA reductase actiyity is maximum in midnightRef: KDT 7e p.637; Clinical pharmacology 3dep.939Because HMG-CoA reductase activity is maximum at midnight, all statins are administered at bed time to obtain maximum effectiveness.However, this is not necessary for atorvastatin and rosuvastatin, which have long plasma t 12. 