<prompt> Enzyme deficiency in Alkaptonuria isTyrosine hydroxylaseHomogentisate acid oxidasePhenyl alanine hydroxylaseCystathione synthase  <response>: B. i.e. Homogentisate oxidase 259 - Harper 27thALKAPTONURIA lack of enzyme homogentisate oxidase enzyme most striking clinical manifestation - occurrence of dark urine black on standing in air Classical type Galactosemia - Galactose-1 p- uridyl transferase enzyme Classical phenylketonuria - Phenyl alanine hydroxylase Type I Tyrosinemia - Fumatyl acetoacetate hydrolase enzyme Type II Tyrosinemia - Hepatic transaminase enzyme. 