<prompt> Which of the following is not a feature of Sipple syndrome?PheochromocytomaMedullary carcinoma thyroidHyperthyroidismHyperparathyroidism  <response>: Ans. is c i.e., Hyperthyroidism Multiple endocrine neoplasia MEN1 MEN-1 Wermer syndrome It involves primarily three glandsa Parathyroid parathyroid hyperplasiaadenoma: Most common manifestation.b Pituitary: Prolactinoma is the most common type of pituitary tumor in MEN-I.c Pancreas: There is let cell hyperplasiaadenoma. Less common findings are pheochromocytoma, foregut carcinoid, lipomas and dermal angiofibroma.2 MEN-IIA sipples syndrome It consists of medullary carcinoma thyroid, parathyroid hyperplasiaadenoma and pheochromocytoma of adrenal medulla.3 MEN-1IB It consists of medullary carcinoma thyroid, pheochromocytoma, GIT neuromas and marfanoid features. 