<prompt> Most common gene associated with renal cell carcinomaWT1BRCA 1VHLPATCH  <response>: Both sporadic and familial RCC is associated with: Loss of sequence on chromosome 3 either by translocation 3:6, 3:8, 3:11 or deletion. This region harbours the VHL gene. Familial RCC is associated with:- Von Hippel-Lindau syndrome Ref: RAM DAS NAYAK EXAM PREPARATORY MANUAL FOR UNDERGRADUATES 2nd ed. pg no: 633 