<prompt> Withdrawal bleeding following administration of progestogen in a case of secondary amenorrhea indicates all exceptAbsence of pregnancyProduction of endogenous estrogenEndometrium is responsive to estrogenDefect in pituitary gonadal axis  <response>: Ans. is d, i.e. Defect in pituitary gonadal axisRef: Dutta Gynae 6thed, p467; Leon Speroff 7thed, p404-409Withdrawal bleeding following administration of progesterone suggests: The uterus is sufficiently primed with estrogen, i.e. production of endogenous estrogen is normal which means. Ovaries and hypothalamic pituitary axis are functioning normally. The outflow tract uterus is normal and endometrium is responsive to estrogen. There is a defect in production of progesterone so pregnancy ruled out. 