<prompt> Increased risk of endometrial and ovarian cancer is seen inHereditary nonpolyposis colorectal cancerPeutz-jeghers syndromeCowdens syndromeAtaxia telangiectasia  <response>: HNPCC or Lynch II syndrome is caused by an inherited mutation in one of the following mismatch repair genes: hMSH2, hMLH1, PMS1, PMS2, or hMSH6. The disorder is characterized by early age average age younger than 45 years at onset of neoplastic lesions in a variety of tissues, including the colon, uterus, stomach, ureters, ovaries, and skin. The lifetime risk of endometrial cancer in women with Lynch II syndrome is 32 to 60 and the lifetime risk of ovarian cancer is 10 to 12. Reference: Novaks gynecology; 14th edition; Chapter 35; Uterine cancer 