<prompt> Mediator of acute inflammation not derived from the cell is:HistamineLeukotrienesCytokinesKinins  <response>: CHEMICAL MEDIATORS OF INFLAMMATIONAka permeability factors or endogenous mediators of increased vascular permeability.They are broadly classified into 2 groups:i. Mediators released by cells.ii. Mediators originating from plasma.CHEMICAL MEDIATORS OF ACUTE INFLAMMATIONA. Cell-Derived Mediators1. Vasoactive aminesHistamine.5-hydroxytryptamine.Neuropeptides.2. Arachidonic acid metabolites Eicosanoidsi. Metabolites via the cyclo-oxygenase pathwayProstaglandins.Thromboxane A2.Prostacyclin.Resolvins.ii. Metabolites via a lipo-oxygenase pathway5-HETE.Leukotrienes.Lipoxins.3. Lysosomal components from PM Ms, macrophages4. Platelet-activating factor PAF5. CytokinesIL-1TNF-α.TNF-β.IFN-γ.Chemokines.6. Free radicalsOxygen metabolitesNitric oxideB. Plasma-Derived Mediators Plasma ProteasesProducts of:1. The kinin system.2. The Clotting system.3. The Fibrinolytic system.4. The Complement system. 