<prompt> In exocrine pancreatic, cancer, the commonest tumor marker to be elevated inCA 125CEACA 15-3CA 19-9  <response>: .Investigations for exocrine pancreatic tumors includes Liver function tests: Serum bilirubin, direct component conjugated is increased van den Berghs test. Serum albumin is decreased with altered A : G ratio. Prothrombin time is widened. Serum alkaline phosphatase is increased US abdomen to see gall bladder, liver, growth, CBD size normal diameter is 10 mm, lymph node status, poal vein, ascites. Barium meal shows widened duodenal C loop-- pad sign. Reverse 3 sign is seen in carcinoma--periampullary region. Spiral CT scan ideal shows poal vein infiltration, retroperitoneal lymph nodes, size of the tumour. ERCP with pancreatic juice cytology or brush biopsy is useful. MRCP to see biliary tree. CA 19-9 carbohydrate antigen is a useful tumour marker. Coeliac and superior mesenteric angiogram can be done to reveal tumour circulation and invasion. Gastroduodenoscopy reveals ampullary tumour and biopsy can also be taken. Endosonography is useful to see the invasion and size, to stage and to do EUS guided FNAC. Urine for bile salts Hays test, bile pigments Fouchets test, urobilinogen. ref:SRB;S manual of surgery,ed 5,pg no 634 