<prompt> Nephrocalcinosis in a systemic granulomatous disease is due to:Overproduction of 1,25 dihydroxy vitamin DDystrophic calcificationMutation in calcium sensing receptorsIncreased reabsorption of calcium  <response>: Nephrocalcinosis Calcification of the renal interstitium and tubules. Associated with hypercalcemia. Disorders associated with hypercalcemia, such as hyperparathyroidism, multiple myeloma, vitamin D intoxication, metastatic cancer, or excess calcium intake milk-alkali syndrome, may induce the formation of calcium stones and deposition of calcium in the kidney nephrocalcinosis. Extensive degrees of calcinosis, under ceain conditions, may lead to chronic tubulointerstitial disease and renal insufficiency. With fuher damage, a slowly progressive chronic kidney disease develops. Sarcoidosis and other granulomatous diseases can be cause of hypercalcemia and hypercalciuria owing to excess vitamin D production from extra renal conversion of 1,25 OH2D3. 