<prompt> Breast conservation surgery is contraindicated inTumor 4 cmMulticentric tumorAxillary LN involvementAll of the above  <response>: .Contraindications Tumour 4 cm Positive axillary nodes N1 Tumour margin is not free of tumour after breast conservative surgery needs MRM Poorly differentiated tumour Multicentric tumour Tumourbreast size ratio is more centeral tumour Tumour beneath the nipple Extensive intraductal carcinoma Ref; page no;553 5th edition of SRB;S manual of Surgery 