<prompt> Heme in hemoglobin is in theHydrophobic pocketPositive regionNegative regionPolar region  <response>: Hemoglobin is found exclusively in red blood cells RBC, where its main function is to transpo oxygen O2 from the lungs to the capillaries of the tissues. Hemoglobin A, the major hemoglobin in adults, is composed of four polypeptide chains two a chains and two b chains held together by noncovalent interactions. Each chain subunit has stretches of a-helical structure and a hydrophobic heme-binding pocket similar to that described for myoglobin. Ref: LIPPINCOTTs Biochemistry 6th Edition page no. 27 