<prompt> What is the best prognostic indicator of multiple myeloma at the time of diagnosis ?Number of myeloma cells in the marrowBeta 2 microglobulinAlkaline phosphatase levelHypercalcemia  <response>: Ans. is b i.e., Beta-2 Microglobulins o Serum 32 microglobulin is the single most powerful predictor of survival and can substitute for staging.P2 Microglobulin level : .004gL Median survival of 43 months. .004 gL Median survival of only 12 months. 