<prompt> Chediak - Higashi syndrome, true is:Defect in phagocytosisNeutropeniaAgammaglobulinemiaIgA deficiency  <response>: Ans. is a i.e., Defect in phagocytosis Ref: CP Baveja, 5the, p. 150 Chediak - Higashi syndrome is a rare autosomal recessive disorder that arises from a mutation of LYST gene codes for lysosomal trafficking regulator protein, which leads to a decrease in phagocytosis. Failure of phagolysosome fusion, defective chemotaxis. The decrease in phagocytosis results in recurrent pyogenic infections, partial albinism and peripheral neuropathy. 