<prompt> Which of the following is not true regarding super-antigens -Bind T cells irrespective of antigen specificity of TCRBind directly to both MHC II and T cell receptor causing T cell activationBind to cleft or antigen binding groove in the MHC II moleculeBinds directly to lateral aspect of T cell receptor  <response>: Superantigens Superantigens are potent activators of T-lymphocytes. Superantigens stimulate very large numbers of T cells, without relation to their epitope specificity. This leads to an excessive and dysregulated immune response with release of cytokines IL - 1, IL - 2, TNF - a and IF - y. Superantigens are capable of activating up to 20 of the peripheral T-cell pool, where as conventional antigens activate 1 in 10, 000. For superantigens, antigen specificity of TCR is not required. 