<prompt> Blockade of nerve conduction by a local anaesthetic is characterized by:Greater potential to block a resting nerve as compared to a stimulated nerveNeed to cross the cell membrane to produce the blockLarge myelinated fibers are blocked before the unmyelinated fibersCause consistent change of resting membrane potential  <response>: Local anesthetics cross the neuronal membrane in un-ionized state and become ionized again in the neuron to block sodium channels. Due to this reason, sodium bicarbonate increases the rapidity of onset of action LA are weak bases and in an alkaline medium easily cross the membrane.Un-myelinated and weakly myelinated fibres are blocked first and then the myelinated ones.These do not affect the resting membrane potential rather inhibit the depolarization.Resting nerves are less sensitive to block by LA than the stimulated nerves. 