<prompt> Which of the following describes humoral hypercalcemia of malignancy HHM?The rise in calcium levels due to PTH-rPParaneoplastic Calcitonin ProductionVitamin D HypervitaminosisParafollicular C-cell proliferation of Thyroid Gland  <response>: The rise in calcium levels due to PTH-rP is termed humoral hypercalcemia of malignancy HHM. A common consequence of some cancers can be increased levels of calcium hypercalcemia with secretion of PTH-related peptide PTH-rP. PTH-rP has significant homology with PTH, but only in the amino-terminal 13 amino acids, which make up the receptor-binding region. Because PTH-rP is not secreted by the parathyroid glands, hypercalcemia produces no feedback regulation of its production. Cancers usually associated with HHM include breast and lung cancers and multiple myeloma. Ref: Kerr J. 2012. Chapter 13. Connective Tissue and Bone. In L.W. Janson, M.E. Tischler Eds, The Big Picture: Medical Biochemistry. 