<prompt> Acantolytic cells in pemphigus is-Cell with hyperchromatic nuclei and perinuclear haloCell with hypochromatic nuclei and perinuclear haloMultinucleated cellsNone of the above  <response>: A. i.e. Cells with hyper chromatic nuclei perinuclear haloAcantholysis is seen in epidermis as loss of cohesion between epidermal cells dt lysis of intercellular substance intercellular adhesion sitesQ. Acantholytic cells are rounded keratinocytes with hyperchromatic nuclei perinuclear haloQ. Acantholysis is seen in pemphigus, Dariers disease, Grovers disease and Hailey-Hailey disease but not in pemphigoid Q.Primary acantholysis i.e. acantholysis is primary pathological change is seen in pemphigus variants vulgaris, vegetans, paraneoplastic, foliaceous, erythematosus, Hailey-Hailey disease familial benign chronic pemphigus, Darriers disease Keratosis follicularis, Grovers disease transient acantholytic dermatosis, persistent acantholytic dermatosis, way dyskeratoma, and eosinophilic spongiosis. Acantholysis i.e. loss of cohesion bw keratinocytes dt breakdown of intercellular bridges result in formation of intraepidermal clefts, vesicles bullae.Secondary acantholysis i.e. secondary to some other pathological change like damage in epidermal cells occurs in bullous impetigo, SSS, viral disorders, solar keratosis squamous cell carcinoma. 