<prompt> Which of the following is involved in 1 carbon metabolism?Folic acidThiaminePyridoxineVitamin B12  <response>: The folic acid is first reduced to 7, 8 - dihydrofolic acid and fuher reduced to 5,6,7,8- tetrahydro folic acid THFA .Both reactions are catalyzed by NADPH dependent folate reductase. The THFA is the carrier of one- carbon groups.One carbon compound is an organic molecule that contains only a single carbon atom.The following groups are one carbon compounds are: 1.Formyl -CHO 2.Formimino - CHNH 3.Methenyl - CH 4.Methylene -CH2- 5.Hydroxymethyl - CH2OH 6.Methyl - CH3 . REFERENCE: DM.VASUDEVAN.TEXTBOOK SEVENTH EDITION PAGE NO 489 