<prompt> Multidrug resistance in TB is defined as resistance toStreptomycin, Rifampicin and IsoniazidIsoniazid and RifampicinStreptomycin and RifampicinStreptomycin and Isoniazid  <response>: Multidrug Resistant TB MDR-TB: Resistance to Isoniazid and Rifampicin with or without resistance to other drugsTreatment of MDR-TB must be done on the basis of sensitivity testingDirectly observed therapy certainly helps to improve outcomes and should be considered an integral part of the treatment of MDR-TB.Extensive Drug Resistant TB XDRTB: Resistance to rifampicin and isoniazid as well as to any member of the quinolone family and at least one of the following second-line TB.TB treatments: kanamycin, capreomycin, or amikacin. 