<prompt> Select the regime of coicosteroids which has the maximum adverse effect potential?Prednisolone 20 mgday oral for one yearPrednisolone 60 mgday oral for 7 daysDexamethasone 4 mg intravenous daily for 3 daysMethyl-prednisolone 1000 mg intravenous twice single dose  <response>: If used for more than two weeks, coicosteroids can lead to HPA axis suppession. If discontinued abruptly, precipitation of acute adrenal insufficiency can result. This is the most serious adverse effect seen with the use of coicosteroids that can cause death of the patient. 