<prompt> Why is Glucose-6-phosphate is not acted upon by Glucose-6-phosphatase enzyme in cytoplasm, even if glycogen synthesis and breakdown takes place in the same cell, having an enzymes present in cytoplasm.Stearic inhibition of phosphatase by albuminGlucose-6-phosphatase is present in endoplasmic reticulum while glycogen metabolism occurs in the cytoplasmIt is thermodynamically ble only when gluconeogenesis is occurringRequire protein kinase for its activation  <response>: Glycogen synthesis as well as breakdown both occurs in cytoplasm But the last step of breakdown of glycogen in liver i.e. glucose -6-phosphate to glucose formation occurs in endoplasmic reticulum and not in cytoplasm, as glucose-6-phosphatase is present in the membrane of endoplasmic reticulum. 