<prompt> led maternal serum a-FP is seen in :Multiple pregnancyTrisomy 21Open neural tube defectIUD  <response>: Ans. is b i.e. Trisomy 21 Low levels of MSAFP Maternal serum alpha feto protein are seen in : Chromosomal trisomy Gestational trophoblastic diseases Blighted ovum Increased maternal weight Overestimated gestational age. Note : The list given in the Williams Obs. 23e, p 291 - Includes fetal death both in causes of increased and decreased AFP. But Fernando Arias 2e, p 38 specifically includes - IUD in the causes of increased AFP and Blighted ovum Aboion in the causes of decreased AFP. 