<prompt> Which one of the following inherited disorders produce thrombosisFactor v leden mutationAntithrombin deficiencyHomocysteinemiaProtein s deficiency p  <response>: ref Robbins 7e p 131, 8e p122 , Harrison 18e p462,9e p123 Homocysteine Hcy is a sulfhydryl amino acid derived from the metabolic conversion of methionine, which is dependent on vitamins folic acid, B12 and B6 as cofactors or cosubstrates. Severe hyperhomocysteinemia homocystinuria, due to inherited metabolic defects of Hcy metabolism, is associated with very high risk of venous thromboembolism VTE; treatment with vitamins is associated with dramatic decrease of VTE risk 