<prompt> All of the following are true statements about membranous nephropathy except?Irregular spikes on silver stainingSelective proteinuriaGranular subendothelial IgG accompanied by C3 depositsSLE is a secondary cause  <response>: Type I MPGN is characterized by the presence of discrete subendothelial electron-dense deposits of IgG and C3 deposited in a granular pattern seen on IF. Membranous nephropathy Diffuse thickening of the glomerular capillary wall due to the accumulation of deposits containing Ig along the subepithelial side of the basement membrane. Basement membrane material is laid down between these deposits, appearing as irregular spikes protruding from the GBM, best seen by silver stains. Results in nephrotic syndrome selective proteinuria Primary cause :Idiopathic 75 Secondary cause : Hepatitis BC infection SLE Diabetes mellitus Drugs NSAIDs, gold, captopril, etc. Cancers malignant melanoma 