<prompt> E6 gene product of HPV causes malignance transformation by acting on ?p53 geneRAS geneC-myc geneN-myc gene  <response>: Ans. is a i.e., p-53 gene HPV selectively infects the epithelium of skin and mucous membrane and may immoalize the keratinocytes leading either asymptomatic infection, or was or neoplasia.Products of E-genes E6, E7 are related to immoalization or malignant transformation of keratinocytes by interfering with p53 and Rb genes, respectively. 