<prompt> True about Cushings syndrome isMost common cause is excess ACTHHigh plasma levels of ACTH and cortisolAlso referred as HyperadrenalismAll of the above  <response>: HyperadrenalismCushings SyndromeHypersecretion by the adrenal cortex causes a complex cascade of hormone effects called Cushings syndrome. Many of the abnormalities of Cushings syndrome are ascribable to abnormal amounts of cortisol, but excess secretion of androgens may also cause important effects. Hypercortisolism can occur from multiple causes, including 1 adenomas of the anterior pituitary that secrete large amounts of ACTH, which then causes adrenal hyperplasia and excess cortisol secretion; 2 abnormal function of the hypothalamus that causes high levels of corticotropin-releasing hormone CRH, which stimulates excess ACTH release; 3 ectopic secretion of ACTH by a tumor elsewhere in the body, such as an abdominal carcinoma; and 4 adenomas of the adrenal cortex. When Cushings syndrome is secondary to excess secretion of ACTH by the anterior pituitary, this is referred to as Cushings disease.Excess ACTH secretion is the most common cause of Cushings syndrome and is characterized by high plasma levels of ACTH and cortisol. 