<prompt> A patient with microcytic hypochromic anemia. Hb-9 g, serum iron-20 microgdl, ferritin level-800 ngml, transferrin percentage saturation is 64. What is possible diagnosis?AtransferrinemiaIron deficiency anemiaDMT 1 mutationAnemia of chronic disorder  <response>: Ans. a AtransferrinemiaRef: Wintrobes 12thpg814This patient with microcytic hypochromic anemia, has high ferritin level 800ngml increased transferrin percentage saturation 64. The most possible diagnosis is Atransferrinemia.AtransferrinemiaIt is a rare congenital autosomal recessive condition with low transferrin level in the body.So whatever transferrin is left, is saturated.It presents with hypochromic microcytic anemia, decreased serum levels of iron, TIBC, and increased serum level of ferritin as iron absorption is markedly increased but iron transfer to eryrthropoetic tissues are reducedHigh transferrin saturation 64 in this case high ferritin level, excludes Iron deficiency Anemia option B excludedIn DMT 1 mutation, transferrin saturation is low hence option C excludedHigh transferrin saturation excludes Anemia of chronic disease option D 