<prompt>  With reference to the optimal management of patients with sepsis in the intensive care unit, all of the following interventions are evidence-based except-Low tidal volume during assisted ventilation prevents acute lung injuryFor outcome of goal-oriented management of sepsis patients, monitoring of central venous pressure, hourly urine output and blood pressure is adequateIntensive blood glucose monitoring and prevention of hyperglycemia improves survival in critically ill patientsThe use of drotrecogin- is restricted to severely ill patients with APACHE score 25 