<prompt> Prompt pump inhibitor suppress gastric acid secretion by acting on:H Cl- ATPase pumpH K ATPase pumpNa K ATPase pumpNa K Cl-ATPase pump  <response>: PPIsproton pump inhibitor: - Irreversible inhibitors- Example of HIT and RUN drugs- Exes systemic effect: normally acid labile, given with acid resistant coating.- DOC for: PUD, GERD, Zollinger Ellison syndrome- Prompt pump inhibitor suppress gastric acid secretion by acting on HK pump. Side effect: chronic use: - Osteoporosisdecrease calcium- Megaloblastic anemiadecrease vitamin B12- Infection 