<prompt> Adenosine deaminase enzyme deficiency is associated with:Severe combined immunodeficiency SCIDX-linked agammaglobulinemiaTransient hypogammaglobulinemia of infancyChronic granulomatous disease  <response>: SCID- defect in common gamma chain of IL2 receptor along with IL-4,7 2nd MC defect is -ADA deficiency total absence of T and B cell deficiency of PNP purine nucleoside phosphorylase X-linked agammaglobulinemia bruttons agamma globulinemia- defect in B tyrosine kinase gene pro B cell to pre B cell formation defect Transient hypogammaglobulinemia- delayed onset of normal IgG synthesis, self limiting. Chronic granulomatous disease- deficiency of NADPH oxidase. led to reccurent catalase positive infection eg.:-staph. 