<prompt> Pick the false statement about pattern recognition receptors out of the following:Toll like receptors are best known of the pattern recognition receptorsToll like receptors are present in the plasma membrane and act by activation of NF-kB and interferon regulatory factorNOD-like receptors NLRs are cytosolic receptors whose mutations lead to autoimmune disordersRIG-like receptors RLRs are located in the cytosol and stimulate the production of antiviral cytokines  <response>: The best known of the pattern recognition receptors are the Toll-like receptors TLRs. The TLRs are present in the plasma membrane and endosomal vesicles. Act by activation of:- NF-kB Interferon regulatory factors IRFs -NOD-like receptors NLRs are cytosolic receptors. They recognize products of necrotic cells, ion disturbances, and some microbial products. Several of the NLRs signal a cytosolic multiprotein complex called the inflammasome, which activates an enzyme caspase-1 that cleaves a precursor form of the cytokine interleukin-1 IL-1 to generate the biologically active form. IL-1 recruits leukocytes and induces fever. Gain-of-function mutations in one of the NLRs result in periodic fever syndromes, called autoinflammatory syndromes. 