<prompt> In blood buffers Bicarbonates buffers is ideal why?Pka is equal to PhHigh concentrationWeak acid and weak base combinationeasy to measure  <response>: High concentration: 711-2- Shinde 8th editionBicarbonate Buffer system Consists of weak acid Carbonic acid H2CO3 and strong base HCO3, NaHCO3 Sodium bicarbonate Normal ratio in blood NaHCO3H2CO3201 They are the chief buffers of blood and constitute the so called Alkali reserve Neutralisation of strong and non volatile acids entering the ECF is achieved by the bicarbonate buffers Bicarbonate buffer system is directly linked up with respiration Bicarbonate buffers system serve as an index to understand the disturbance in the acid base balance of the body 476- U. Satyanarayan 4thAdvantages of bicarbonate buffer system It is present in very high concentration than other buffer system 26 to 28 millimole per littre Produces H2CO3 which is weak acid and volatile and CO2 is exhaled out Hence it is a very good physiological buffer and acts as a front line defense.Disadvantages - As a chemical buffer, it is rather weak, pKa is further away from the physiological pH 