<prompt> The cause of hyperuricemia and gout in glucose-6-phosphatase deficiency is:More formation of ribose 5-phosphateDecreased availability of glucose to tissuesIncreased accumulation of sorbitolImpaired degradation of free radicals  <response>: Type I glycogen storage disease Von Gierkes Disease is an autosomal recessive disorder caused by glucose-6-phosphatase deficiency in liver, kidney, and intestinal mucosa. Purine overproduction and hyperuricemia in von Gierke disease glucose-6-phosphatase deficiency occurs secondary to enhanced generation of the PRPP precursor ribose 5-phosphate. An associated lactic acidosis elevates the renal threshold for urate, elevating total body urates. Ref: Rodwell V.W. 2011. Chapter 33. Metabolism of Purine Pyrimidine Nucleotides. In D.A. Bender, K.M. Botham, P.A. Weil, P.J. Kennelly, R.K. Murray, V.W. Rodwell Eds, Harpers Illustrated Biochemistry, 29e. 