<prompt> Drug with beta adrenergic blocking, with antioxidant, with calcium channel blocking, with alpha 1 antagonist activity is -EsmololCarvedilolNebivololLevobunolol  <response>: Ans. is b i.e., Carvedilol Carvedilolo Carvedilol is b1 b2 a1 adrenoceptor blocker with a : b blocking property of 1 : 9.o It has antioxidant and antimitotic property.o It produces peripheral vasodilation due to a-l blockade as well as calcium channel blockade direct effect.o It is used in hypertension and angina.o It is used as cardioprotective in CHF.o t 12 is 2-8 hrs.o It is eliminated through liver and kidney,o It causes orthostatic hypotension. 