<prompt> Which of the following is the established biological therapy for Crohns disease -Anti TNF a-antibodyIL-1 antagonistIL-6 antagonistIL-8 antagonist  <response>: Ans. is a i.e., Anti TNF a antibody Biological compoundsAgents which are derived from natural substances and are then chemically altered. The biological compound that has been approved for use in Crohns colitis by FDA is - Infliximab.Infliximab is a chimeric antibody consisting of the variable region of a murine antibody to TNF-a joined to the Fc constant region of a human antibody.Mechanism of action of Infliximab - Inhibits Tumour Necrosis Factor a or b.UsesIt has been approved by FDA for use inRheumatoid arthritisCrohns colitisAn important adverse effect of infliximab use is - TuberculosisCurrent status of development of Immunomodulatory drugDrugMechanism of actionUses Adalimumab Fully humanized MabInhibits TNF-aRheumatoid arthritis Etanercept Recombinant TNF receptor Ig fusion proteinInhibits TNF-aRheumatoid arthritis Juvenile Rheumatoid arthritis Psoriasis Anakinra Recombinant IL-1 receptor antagonistInhibit IL-1a bRheumatoid arthritis Anti-CD3,T cell monoclonal antibodyInhibit T cell function, Induce T cell lymphopeniaTT of cardiac and renal allograft rejection IVIgReticuloendothelial cell blockage, Complement inhibition, Regulation of idiotypeantidio typeKawasakis disease Immune thrombocytopenic purpura Remember these important points IL-12-It is under trial for tt of mycobacterial infections. Trials are also underway for use in cancer patients. IL-2-In trial for tt of HIV infection IL-11-In trial for Crohns colitis 