<prompt> Mitochondrial chromosomal abnormaity leads to ?Lebers hereditary optic neuropathyAngelman syndromePrader villi syndromeMyotonic dystrophy  <response>: Ans. is a i.e., Lebers hereditary optic neuropathy o Diseases associated with mitochondrial inheritance are rare and many of them affect the neuromuscular system. o Leber hereditary optic neuropathy is a prototype of this disorder. It is a neurodegenerative disease that manifests itself as progressive bilateral loss of central vision. Visual impairment is first noted between ages 15 and 35, and it leads to blindness. Cardiac conduction defects minor neurologic manifestations have also been seen in some families. 