<prompt> One of the following caused nephrotoxicity -AzathioprineCyclophosphamideMycophenolate mofetilTacrolimus  <response>: Tacrolimus Tacrolimus is a macrolide immunosuppressant that is isolated from bacterium. It is used for the same purpose as cyclosporine i.e., it is being used to protect and treat liver and kidney grafts when conventional immunosuppressants fail. It suppresses the cell mediated immunity but it leaves patient with enough immunity to fight bacteria. Despite major differences in the chemical structure, tacrolimus and cyclosporine seems to have many effects in common:? It acts like cyclosporine Both the drugs inhibit the calcineurin pathways. Their adverse effect on kidney is indistinguishable i.e., - Tubular lesions - Aeriolopathy - Tufts like changes in glomeruli and vessels. Adverse effect of Azathioprine Goodman Gilman 12the p. 1415 Bone marrow Suppression - Leucopenia common - Thrombocytopenia less common Increased susceptibility to infections Hepatotoxicity Alopecia G.I.toxicity Pancreatitis Increased risk of neoplasia Adverse effects of mycophenolate mofetil Goodman Gilman 12the p1414 Gastrointestinal - Diarrhoes - Vomiting Hematological - Leucopenia - Anemia - Thrombocytopenia Sepsis associated with cytomegalovirus Adverse lipid profile Increased risk of malignancy and pancreatitis Abnormal liver functions tests - Hepatitis - Electrolyte disturbance Adverse effect of Leflunomide Diarrhoea 40 Other gastrointestinal disturbances Allergic responses Alopecia Hypeension Leucopenia Abnormal liver function tests 