<prompt> Which propey of hemoglobin is affected in sickle cell anemia?StabilityFunctionAffinitySolubility  <response>: Sickle cell disease is a hereditary hemoglobinopathy with structurally abnormal hemoglobinThe Normal adult red cell contains 96 HbA a2b2, 3 HbA2 a2d2, and 1 fetal Hb HbF, a2g2.Sickle cell disease is caused by a point mutation in the 6th codon of b-globin chainOccur primarily in African blacks This high frequency stems from the protection afforded by HbS against falciparum malariaHeterozygotes for HbS is called as sickle cell trait aabsbHomozygous for Hbs is called as sickle cell disease HbS aabsbs Pathogenesis:The solubility of hemoglobin is altered affected in HbSRef: Robbins 8e p645, T. singh 1e p270 