<prompt> In which of the following combinations of auto antibodies are both antibodies used in the diagnosis of the same autoimmune disease?Anti-SS-A Ro and anti-centromere antibodiesAnti-smith Sm and anti-double-stranded DNA antibodiesAnti-ribonucleoprotein and anti-histone antibodiesAnti-SS-B La antibodies and anti-single -stranded DNA antibodies  <response>: Anti-Smith Sm and anti-double-stranded DNA antibodies are both used in the diagnosis of systemic lupus erythematosus SLE. Anti-Sm Smith antibodies are less sensitive 30 than anti-double-stranded DNA 60 to 70, but are more specific 100. Regarding the other choices: Anti-SS-A Ro antibodies are positive in Sjogren syndrome and anticentromere antibodies are positive in CREST syndrome. Anti-ribonucleoprotein has a high specificity for mixed connective tissue disease. Anti-histone antibodies have a high specificity 95 in drug-induced SLE. Anti-SS-B La antibodies have a high specificity 60-90 for Sjogren syndrome. Anti-single-stranded DNA antibodies are commonly seen in drug-induced SLE. Anti-mitochondrial antibodies have a high specificity for primary biliary cirrhosis. Anti-microsomal antibodies are seen in Graves disease and Hashimotos thyroiditis. Ref - Harrisons principles of internal medicine 20e pg 2515, 2516f, 2517t, 2518t, 2522 