<prompt> Which virus is implicated in Burkitts lymphoma?HTLVHPVEBVHHV8  <response>: Explanation: BURKITT LYMPHOMA There are three clinical types:1. African endemic Burkitt lymphoma.2. Sporadic nonendemic Burkitt lymphoma.3. Aggressive lymphomas associated with HIV.These 3 types are histologically identical. Morphology The tumor exhibits a high mitotic index and contains numerous apoptotic cells,the nuclear remnants of which are phagocytosed by interspersed benign macrophages.These phagocytes have abundant clear cytoplasm, creating a characteristic starry sky pattern. Immunophenotype These are tumors of mature B cells.It express surface IgM, CD 19, CD20, CD 10 and BCL6. a phenotype consistent with a germinal center B-cell origin.Unlike other tumors of germinal center origin, this does not express anti-apoptotic protein BCL2.Molecular Pathogenesis All forms of Burkin lymphoma are associated with translocations of the c-MYC gene on chromosome 8.The translocation partner is usually the IgH locus light-chain loci.All endemic tumors are latently infected with EBV. which is also present in about 25 of HIVassociated tumors and 15 to 20 of sporadic cases.Clinical Features Endemic Burkitt lymphoma often presents as a mass involving the mandible and shows an unusual predilection for involvement of abdominal viscera,particularly the kidneys, ovaries and adrenal glands. Sporadic Burkitt lymphoma most often appears as a mass involving the ileocecum and peritoneum.Burkitt lymphoma is very aggressive but responds well to intensive chemotherapy 