<prompt> Overdose of vitamin A mainly affects ___CytosolMitochondriaLysosomeCell membrance  <response>: Hypervitaminosis A Common in arctic explorers who eat polar bear liver Organelle damaged in hypervitaminosis is Lysosomes Acute toxicity: Pseudotumor cerebri headache, dizziness, vomiting, stupor, and blurred vision, symptoms that may be confused with a brain tumor and exfoliative dermatitis. In the liver, hepatomegaly and hyperlipidemia Chronic toxicity: If intake of 50,000 IUday for 3 months Weight loss, anorexia, nausea, vomiting, bony exostosis, bone and joint pain, decreased cognition, hepatomegaly progresses to cirrhosis In pregnancy, retinoids cause teratogenic effects. ref DM Vasudevan 8th ed page 457 