<prompt> Growth hormone has its effect on growth through?DirectlyIG1-1ThyroxineIntranuclear receptors  <response>: Ans. is b i.e., IGI-1GH has two major functions :-i Growth of skeletal system :- The growth is mediated by somatomedins IGF. Increased deposition of cailage including chondroitin sulfate and bone with increased proliferation of chondrocytes and osteocytes.ii Metabolic effects :- Most of the metabolic effects are due to direct action of GH. These include gluconeogenesis, decreased peripheral utilization of glucose decreased uptake, lipolysis and anabolic effect on proteins. 