<prompt> When nitrates are combined with Calcium channel blockersAerial pressure will decreaseHea rate will increaseEjection time will decreaseEnd diastolic volume will increase  <response>: Really Kk sharma 1e p276 Recommendations for combination therapy decisively depend on the choice of the first-line drug. Only nitrates reduce myocardial preload by venodilation and substitute for EDRF-deficiency. ... Therefore, the combination of nitrates with hea-rate-increasing calcium channel blockers, such as nifedipine, should be avoided. 