<prompt> Screening test for sclerodema?Anti-nuclear antibodyU l- Ribonucleoprotein antibodyAnti- L.K.M antibodyAnti- topoisomerase antibody  <response>: Anti-nuclear antibody- ANA is the screening method of choice for systemic rheumatic disease such as systemic lupus ehyematosus SLE, mixed connective tissue disease, Sjogren syndrome, scleroderma, CREST syndrome, rheumatoid ahritis, polymyositis, and dermatomyositis. 