<prompt> The characteristic facies of the following may resemble that of Downs syndrome:Rhizomelic chondrodysplasiaInfantile Refsum diseaseZellweger syndromeNeonatal adreno leukodystrophy  <response>: C Zellweger syndrome ZELLWEGER SYNDROME: Children demonstrate facial dysmorphology with a prominent forehead, large anterior fontanellae, epicanthal folds, micrognathia, high arched palate, and deformed ear lobes. Characteristic Zellweger syndrome facies may resemble that of Downs syndrome. Other features include profound hypotonia, hepatic dysfunction, hepatomegaly, retinal degeneration, sensorineural hearing loss, renal cysts and calcific stippling of the epiphyses. Peroxismol biogenesis disorders PBDs include Zellweger syndrome, Neonatal adrenoleukodystrophy NALD, infantile Refsum disease IR, Rhizomelic chondrodysplasia punctata RCP. Zellweger syndrome, NALD, and IRD represent a spectrum of disroders with similar and overlapping clinical features. 