<prompt> Mechanism of action of Pemetrexed is:-RNA synthesis inhibitorDihydrofolate reductase inhibitorDopamine agonistTopoisomerase inhibitor  <response>: Dihydrofolate reductase Inhibitors Methotrexate Pralatrexate Pemetrexed PEMETREXED - used in mesothelioma D: Topoisomerase introduces negative coils and aids in replication IRINOTECAN - topoisomerase Inhibitor 