<prompt> In hashimotos disease serum antibodies are mainly against -a Thyroid folliclesb Thyroxinec Thyroglobulinsd Iodineabcacb  <response>: Hashimotos Thyroiditis -Hashimotos thyroiditis is an autoimmune disorderIt is the most common cause of primary hypothyroidismIt mainly affects middle aged femalesAlthough it is primarily a disease of the middle aged females, it can occur in children and is a major cause of nonendemic goitre in children.Pathogenesis -Hashimotos thyroiditis is an autoimmune disorder characterized by the presence of following IgG antibodies -Antithyro globulin antibody Antimicrosomal antibody Antibody directed against a component of colloidAntibody against TSH receptorsThese antibodies do not correlate with severity of disease.They have a diagnostic value 