<prompt> Highly selective proteinuria is seen inMinimal changeMesangial proliferative nephritisMembranous glomerulonephritisFocal glomerulosclerosis  <response>: Loss of glomerular basement membrane GBM polyanion has been proposed as a cause of the selective proteinuria in minimal change nephrotic syndrome MCNS.The exact role of charge selectivity in the pathogenesis of nephrotic proteinuria remains controversial Proteinuria that is more than 85 albumin is selective proteinuria. Nonselective proteinuria, being a glomerular leakage of all plasma proteins, would not involve changes in glomerular net charge but rather a generalized defect in permeability Ref Harrison20th edition pg 287 