<prompt> A resident doctor sustained a needle stick injury while sampling blood of a patient who is HIV positive. A decision is taken to offer him post-exposure prophylaxis. Which one of the following would be the best recommendation?Zidovudine Lamivudine for 4 weeksZidovudine Lamivudine Nevirapine for 4 weeksZidovudine Lamivudine Indinavir for 4 weeksZidovudine Stavudine Nevirapine for 4 weeks.  <response>: Ans. is c i.e. Zidovudine Lamivudine Indinavir for 4 weeksRef. Harrison. 16the p 1136, 37 15the, pl990Needle stick injury is the most common cause of HIV infection among health care workers.The guidelines for post-exposure prophylaxis of HIV areFor routine exposuresa combination of two nucleoside reverse transcriptase inhibitors for 4 weeks.For high risk or complicated exposuresa combination of two nucleoside reverse transcriptase inhibitors plus a protease inhibitor for 4 weeks.In spite of the guidelines regimen B is given for all types of exposureThus the treatment is obvious in this doctor.Also Remember Examples of Nucleoside reverse transcriptase inhibitors Protease inhibitors Zidovudine Saquinavir Lamivudine Indinavir Stavudine Ritonavir Didanosine Nelfinavir Zalcitabine Amprenavir Abacavir 