<prompt> Bone marrow plasmacytosis in multiple myeloma is characteristically more than: September 201110203040  <response>: Ans. C: 30 Manifestations of multiple myeloma includes bone marrow plasmacytosis of more than 30 Multiple myeloma: MC symptomatic monoclonal gammopathy Histology: Russel bodies, flame cells, Mott cells, Dutcher bodies Presents as pathological fractures with hypercalcemia, M-spike and Bence-Jones proteins light chains TL-6 is associated with poor prognosis Raised calcium and raised uric acid WHO criteria major: Bone marrow plasmacytosis more than 30 Plasmacytoma on biopsy Presence of monoclonal M protein M component in urineserum Serum IgG more than 3.5 g dl, or Serum IgA more than 2 g dl, or Urine Bence-Jones protein more than 1 gmday WHO criteria minor: Bone marrow plasmacytosis of 10 - 30 Presence of monoclonal M protein M component in urine serum, but less than the above concentration Presence of lytic bone lesions Reduced normal immunoglobulins to less than 50 of normal IgG less than 600 mg dl, or IgA less than 100 m dl, or IgM less than 50 mg dl Diagnostic requirement: Minimum of 1 major criterion and 1 minor criterion, or 3 minor criterion which must include bone marrow plasmacytosis of 10 - 30 and the presence of a monoclonal rotein These criteria must be manifested in a symptomatic patient with progressive disease 