<prompt> T4T8 ratio reversal is seen in -T-cell lymphomaHairy cell leukemiaAIDSInfectious mononucleosis  <response>: The T-Lymphocyte HelperSuppressor Profile HelperSuppressor ratio, T4:T8 ratio, CD4:CD8 ratio is a basic laboratory test in which the percentage of CD3-positive lymphocytes in the blood positive for CD4 T helper cells and CD8 a class of regulatory T cells are counted and compared. Normal values 95 confidence intervals are approximately 30-60 CD4 and 10-30 CD8 depending on age ratio 0.9 to 3.7 in adults. One reason for abnormal results is the loss of CD4-positive cells to the Human Immunodeficiency Virus HIV infection. The loss of CD4-positive cells to HIV infection can result in various distoions in the ratio, as in the initial period, production of HIV specific CD8 positive cells will cause a large fall in the ratio Reff: clinic.com 