<prompt> What is the cause of hypercoagulation in nephrotic syndrome:Loss of antithrombin III AT IIIDecreased fibrinogenDecreased metabolism of vitamin KIncrease in Protein C  <response>: Thrombotic and thromboembolic complications are common in nephrotic syndrome due to loss of anticoagulant factor e.g. antithrombin III, protein C and S combined with increased platelet activation. Renal vein thrombosis is most often a consequence of this hypercoagulative state. There is also increased synthesis of fibrinogen in the liver. 