<prompt> Which of the following statements about imipenem is most accurate?The drug has a narrow spectrum of antibacterial actionIt is used in fixed dose combination with sulbactumIn renal dysfunction, dosage reductions are necessary to avoid seizuresImipenem is active against methicillin-resistant staphylococci  <response>: Carbapenems are synthetic b-lactam antibiotics Imipenem, meropenem, doripenem and eapenem are the drugs of this group currently available. Imipenem : Effective against : Gm ve, Gm -ve including pseudomonas and anaerobic. Dehydropeptidase by kidney metabolises imipenem rapidly. Cilastatin is a dehydropetidase inhibitor, which must be given along with imipenem for desired action. Side effect : Seizure 