<prompt> Which of the following gene mutations is most commonly associated with systemic mastocytosis?CALRJAK2KITMPL  <response>: Myeloproliferative neoplasms Disorder MutationTranslocation Chronic myeloid leukemia BCR-ABL1 fusiontranslocation Polycythemia vera JAK2 mutations Essential thrombocythemiaPrimary myelofibrosis JAK2, CALR, MPL mutations Systemic mastocytosis KIT mutations Chronic eosinophilic leukemia FIP1L1-PDGFRA fusion genePDE4DIP-PDGFRB fusion gene Chronic neutrophilic leukemia CSF3R mutations Myeloid neoplasms with eosinophilia Various fusion genes involving FGFR1, PDGFRA, PDGFRB, or JAK2 