<prompt> Cobble stone appearance is seen in:Ulcerative colitisCrohns diseaseAppendicitisCarcinoma rectum  <response>: Crohns Disease Earliest gross pathologic lesion is a superficial aphthous ulcer noted in the mucosa. Linear ulcers may coalesce to produce transverse sinuses with islands of normal mucosa in between cobblestone appearance Characteristic histologic lesions of Crohns disease are noncaseating granulomas with Langerhans giant cells. 