<prompt> A 50 year old male, working as a hotel cook, has four dependent family members. He has been diagnosed with an early stage squamous cell cancer of anal canal. He has more than 60 chances of cure. Which of the following is the best treatment option?Chemotherapy aloneAbdominoperineal resectionCombined surgery and radiotherapyCombined chemotherapy and radiotherapy  <response>: A combination of chemotherapy and radiotherapy, so-called chemo radiation Nigro is the preferred initial therapy for all anal canal tumours. In such patients a combination of 5 flourouracil and mitomycin is given for approximately 1 week and chemotherapy is followed by radiotherapy, given over 3-7 weeks. Ref: Bailey and Loves Sho Practice of Surgery, 24th Edition, Pages 1269-1271. 