<prompt> Number of ATP generated in one TCA cycle-251011  <response>: Ans. is c i.e., 10 o In a single TCA cycle 10 molecules of ATP are produced 12 molecules according to older calculations,o One turn of the TCA cycle, starting with acetyl Co A produces 10 ATPs. When the starting molecule is pyruvate, the oxidative decarboxylation of pyruvate, the oxidative decarboxylation of pyruvate yields 2.5 ATPs and therefore, 12.5 ATPs are produced when starting compound is pyruvate. Since, two molecules of pyruvate enter the TCA cycle when glucose is metabolized glycolysis produces 2 molecules of pyruvate, the number of ATPs is doubled. Therefore, 25 ATP molecules, per glucose molecule, are produced when pyruvate enters the TCA cycle,o Note : Previously calculations were made assuming that NADH produces 3 ATPs and FADH generates 2 ATPs. This will amount a net generation of 30 ATP molecules in TCA per molecule glucose and total 38 molecules from starting. Recent experiments show that these values are overestimates and NADH produces 2.5 ATPs and FADH produces 1.5 ATPs. Therefore, net generation during TCA is 25 ATPs and complete oxidation of glucose through glycolysis plus citric acid cycle yield a net 32 ATPs.o Energy yield number of ATP generated per molecule of glucose when it is completely oxidized through glycolysis plus citric acid cycle, under aerobic conditions, is as follows :- Method of ATP formationNo of ATPs gained perglucose new calculationNo of ATPs As per old calculationPathwayStepEnzymeSourceGlycolysis1Hexokinase- Minus1Minus 1Do3Phosphofructokinase- Minus1Minus IDo5Glyceraldehyde-3-p DHNADHRespiratory chain2.5x2 53x26Do61J-BPG kinaseATPSubstrate level1x2 21x22Do9Pyruvate kinaseATPSubstrate level1x2 21x22Pyruvate to Acetyl CoA-PyruvateDehydrogenaseNADHRespiratory chain2.5 x 2 53x26 TCA cycle3Isocitrate DHNADHRespiratory chain2.5 x 2 53x26Do4Alpha keto glutarate DHNADHRespiratory chain2.5 x 2 53x26Do5Succinate thiokinaseGTPSubstrate level1x2 21x22Do6Succicinate DHFADH2Respiratory chain1.5 x 2 32x24Do8Mai ate DHNADHRespiratory chain2.5 x 2 53 x 2 6Net generation in glycolytic pathway 9 minus 2710 minus 28Generation in pyruvate dehydrogenase reaction56Generation In citric acid cycle2024Net generation of ATP from one glucose mole3238 