<prompt> Rosenthal fibres are seen in-Heat, shock proteinsFibrillar proteinsGFAPGlobulins  <response>: A Rosenthal fiber is a thick, elongated, worm-like or corkscrew eosinophilic pink bundle that is found on HE staining of the brain in the presence of long-standing gliosis, occasional tumors, and some metabolic disorders. ASSOCIATED CONDITIONS Its presence is associated with either pilocytic astrocytomamore common or Alexanders disease a rare leukodystrophy. They are also seen in the context of fucosidosis. COMPOSITION The fibers are found in astrocytic processes and are thought to be clumped intermediate filament proteins. Their components include glial fibrillary acidic proteinGFAP. Ref: Wikipedia 