<prompt> Peau dorange in carcinoma breast is due to:AIIMS November 2015, DNB 2012, PGI June 95, December 95Obstruction of sub-dermal lymphaticsInfiltration of Coopers ligamentHematogenous disseminationNipple involvement  <response>: Ans. a. Obstruction of suh-dermal lymphatics Ref: Bailey 26e p811, 25e p840Peau-d-orange is due to cutaneous lymphatic edema, caused by obstruction of subdermal lymphatics.Peau-d-orangePeau-d-orange is due to cutaneous lymphatic edema, where the infiltrated skin is tethered by sweat ducts, it can not swell, leading to an appearance like orange skinQ.Due to obstruction of subdermal lymphatics lymphatic permeation by tumor cellsQSeen in advanced breast cancerQ may be seen in chronic abscessQ 