<prompt> Herpes Zoster or Shingles represents reactivation and replicationn of Latent infection in:Dorsal Root GanglionAnterior Horn CellPeripheral nerveEpithelium of Skin  <response>: Herpes zoster shingles is caused by the reactivation and multiplication Replication of the Varicella -zoster virus VZV in the dorsal root ganglion. Herpes zoster, is a localized disease characterized by unilateral radicular pain and a vesicular rash limited to the area of skin innervated by a single dorsal root or cranial sensory ganglion. Reactivation of Latent Varicella Zoster: Varicella Zoster Virus remains latent in sensory ganglia including dorsal root ganglia of the spinal cord most frequently and other ganglion including trigeminal ganglion andor geniculate ganglion. Chicken Pox: Virus enters sensory nerve endings and travels in retrograde fashion to sensory ganglia where it remains latent. Reactivationreplication in dorsal root ganglion: Virus travels back from ganglia along sensory nerves to the peripheral nerves of sensory dermatomes causing ;shingles; Herpes ZosterShingles: Unilateral vesicular eruption within a dermatome associated with severe pain. The dermatomes from T3 and L3 are most frequently involved Reactivationreplication in Trigeminal Ganglion: Virus travels back from trigeminal ganglia, most often along first division of cranial nerve V causing Zoster Ophthalmicus. Other divisions may also be involved lesions may appear on the face, in the mouth or on the tongue. Herpes Zoster Ophthalmicus Reactivationreplication in geniculate ganglion: Virus travels back from the geniculate ganglion along the sensory distribution of facial nerve causing Herpes Zoster Oticus or the ;Ramsay Hunt Syndrome; Ramsay Hunt Syndrome: Pain and vesicles appear in the external auditary canal. Patients lose their sense of taste in anterior 23rd of the tongue and develop ipsilateral facial nerve palsy. Ref: Harrison, Jawetz Microbiology, Rubin;s Pathology 