<prompt> Which of the following factors has maximum effect on filtration of a drug by the glomerulus ?Lipid solubilityPlasma protein bindingDegree of ionizationRate of tubular secretion  <response>: - Main Factors determining glomerular filtration Renal blood flow Plasma protein binding- Lipid solubility does not affect glomerular filtration.- Ionization determines tubular reabsorption. - Tubular secretion happens after glomerular filtration and so does not affect the process. 