<prompt> All are true about sulphonyl ureas except?It blocks ATP sensitive K channels and increase insulin releaseThey have higher risk of causing hypoglycemia than meglitinidesThey are used mainly in type 1 DMChlorpropamide can cause dilutional hyponatremia  <response>: Sulphonyl ureas are mainly used in Type 2 DM because Type 1 DM is characterized by autoimmune destruction of β - cells of pancreas and atleast 30 of β - cells should be present for sulphonyl ureas to be effective. 