<prompt> Glyceryl trinitrate is given by sublingual route because of:Short t12 in plasmaHigh hepatic first pass metabolismHigh bioavailability by oral routeExtensive protein binding  <response>: Ans. B High hepatic first pass metabolismRef: KDT 8the p588Main advantage of sublingual route of drug administration is that liver is bypassed and drugs with high first pass metabolism are absorbed directly into systemic circulation. 