<prompt> The hyperkinetic features of the Huntingtons disease are due to the loss of:Nigrostriatal dopaminergic systemIntrastriatal cholinergic systemSubthalamic neuronsIntrastriatal GABA-ergic and cholinergic system  <response>: Corpus striatum sends inhibitory input to globus pallidus external; globus pallidus is reciprocally connected with subthalamic nucleus. In Huntingtons disease there is loss of inhibitory GABAergic and cholinergic neurons of the striatum. Loss of dopaminergic neurons in the nigrostriatal tract will lead to Parkinsons disease. Huntingtons disease is a trinucleotide repeat disorder with multiple CAG repeats. 