<prompt> Which of the following fluoroquinolones does not require dose adjustment in a patient with creatinine clearance of 50mgmin -CiprofloxacinTrovafloxacinLomefloxacinSparfloxacin  <response>: Ans. is b i.e., Trovofloxacin Fluoroquinolones that are excreted primarily by non renal mechanism and for which adjustment is not needed in renal pathology include : Nalidixic acid 3. Trovafloxacin 5. Moxifloxacin Grepofloxacin 4. Pefloxacin Fluroquinolones that are primarily excreted by renal mechanisms and for which dose adjustment is needed include: 1. Ciprofloxacin 3. Gatifloxacin 5. Lomefloxacilin 7. Ofloxacin 2. Cinafloxacin 4. Levofloxacilin 6. Norfloxacin Sparfloxacin has 50 renal and 50 faecal route of excretion and hence dose adjustment may be required in renal pathology. 