<prompt> Huntingtons disease is due to the loss of :Nigrostriatal dopaminergic neuronsIntrastriatal cholinergic neuronsIntrastriatal GABAergic neuronsIntrastriatal cholinergic and GABAergic neurons  <response>: Answer is D Intrastrial cholinergic and GABAergic neurons: The repoed abnormality in Huntingtons disease suggests a relative under activity of neurons containing gammaaminobutyric acid GA BA and acetylcholine - CMDT 2005 980 There is severe loss of striatal neurons, the most dramatic changes being found in the caudate nucleus - Robbins 7th 1394 Caudate nucleus is pa of striatum 