<prompt> Cause of vasodilation in spider neviTestosteroneEstrogenFSHHepatotoxin  <response>: B i.e. EstrogenIn chronic liver disease especially cirrhosis and pregnancy, impaired estrogen metabolism and consequent hyper estroenemiaQ leads to spider angiomatanevi superficial, toous aerioles, that unlike simple telangiectases, typically fill from the center outwards and occur invariably on upper half of body and palmar erythema mottled redness of thenar hypothenar eminences. 