<prompt> Molecular change in Lysosomal storage disorder is:Defective fusion of lysosomes and phagosomesIncreased synthesis of some substratesMutation of genes encoding lysosomal hydrolasesMembrane defect of lysosomes  <response>: C i.e. Mutation of genes encoding lysosomal hydrolasesLysosomal storage diseases LSD are caused by mutations in genes encoding lysosomal hydrolasesQ responsible for breaking down of macromolecules, which results in accumulation of corresponsing substrate macromolecule. ISDs are classified on the basis of accumulated substrate into sphingolipidosis, mucolipidosis, mucopolysaccharidoses, glycoproteinoses etc. 