<prompt> Which of the following statements regarding transfer of drugs across placenta is FALSE ?Transfer across placenta is lesser in early pregnancyAll drugs to some extent can cross the placenta except heparin and insulinIon trapping of acidic drugs occur in the placentaPglycoprotein is present in placenta  <response>: Heparin and insulin are anticoagulant and antidiabetic drugs of choice, respectively in pregnancy becasue these have minimum entry across placentaFetal plasma is slightly more acidic than that of mother pH 7.0 as compared to 7.4 of mother, so ion trapping of basic drugs occur.Placenta contain P-glycoprotein that can act as an efflux pump for drugs.Placental transfer of most drugs is greater in late pregnancy than in early pregnancy because uterine circulation increases and trophoblastic layer becomes thinner as the pregnancy advances. 