<prompt> Potassium sparing diuretics acts On:Na K pumpAldosterone receptorCarbonic anhydraseNa Cl- sympoer  <response>: These are either aldosterone antagonist or directly inhibit Na channels in DT and CD cells to indirectly conserve K. Potassium-sparing diuretics - Spironolactone Aldosterone antagonist Amiloride, Triamterene inhibit renal epithelial Na channel Mechanism of action: aldosterone binds to aldosterone receptor first in the collecting ducts- AR complex induces growth of ENAC or stimulation of ENAC- epithelial sodium channels- leading to loss of potassium in the urine and sparing of sodium in the plasma now if spironolactone is administered, blocks AR complex- opp actions will be seen- potassium will be spared inside the body leading to loss of sodium in the urine Essentials of Medical Pharmacology, K.D Tripathi,6th edition 