<prompt> Oxidative decarboxylation of pyruvate requiresNADPCytochromespyridoxal phosphateCOASH  <response>: Inside the mitochondria, pyruvate is oxidatively decarboxylated to acetyl CoA by pyruvate dehydrogenase PDH. It is a multi-enzyme complex with 5 co-enzymes and 3 apo-enzymes.The co-enzymes needed are:Thiamine pyrophosphate TPPCo-enzyme A CoAFADNADLipoamide.The enzyme part of the PDH complex is made up of three component enzymes.Reference: Vasudevan 7th ed, pg 116 