<prompt> In MEN I, which is seen most commonly :InsulinomaGastrinomaGlucagonomaSomatostatinoma  <response>: Answer is B Gastrinoma: Amongst the options provided Gastrinomas are the most common association with MEN I. Gastrinomas Insulinomas Glucagonomas VIPomos Somatostainomas MEN I Parathyroid tumors Most Common Hyperparathyroidism is the 1110S1 common manifestation of MEN I -Harrison Relative frequency of Tumors causing FR perparathyroidism : Parathyroid hyperplasia is the most common cause of hyperparathyroidisin in MEN 1 Parathyroid adenomas are less common than parathyroid hyperplasia and tend to occur in older patient or those with long standing disease. Pancreatic endocrine tumors Second Most Common Neoplasia of the pancreatic islets is the second most common manifestation of MEN P. -Harrison Relative frequency of Endocrine Tumors of Pancreatic Islets : Pancreatic polypeptide 75 - 85 Gastrin 60 Gastrinomas ZES Insulin 25 - 30 Insulinomas Glucagon 5 - I0Glucagonoma VIP 3 - 5 VIPomas Somatostatin I - 5 Somatostatinoma Pituitary tumors Third Most Common Pituitary tumors are third most common tumors of MEN 1 and occur in more than half of patients with MEN 1 Relative frequency of Pituitary Tumors : Prolactinomas are the most common pituitary tumors in MEN I Acromegaly due to excessive growth hormone GH production is the second most common pituitary tumor in MEN I Cushings syndrome VIPoma is synonymous with Verner Morrison syndrome or Water Diarrhea Syndrome or Pancreatic Cholera. Other Tumors in MEN I Carcinoid tumours lbregut type : derived from lung,thymus,stomach or duodenum Subcutaneous visceral lipomas Cutaneous leiomyomas Skin angiofibromas or collagenomas 