<prompt> Which of the following is effective in management of patients of hea failure with preserved ejection fraction?DigoxinARB with neprilysin inhibitorIsosorbide mononitratePhosphodiesterase inhibitor  <response>: HFpEF hea failure with preserved ejection fraction- A.R.N.I ARB Nephrilysin inhibitor HFrEF hea failure with reduced ejection fraction- ACE inhibitor Beta Blocker Phosphodiesterase inhibitor: RELAX trial- no improvement in functional capacity, quality of life QOL, or other clinical and surrogate parameters in patients with HFpEF. Isosorbide mononitrate: NEAT-HFpEF trial- no improvement in QOL or submaximal exercise capacity in patients with HFpEF Digoxin Digitalis Investigation Group DIG found no role for digoxin in the treatment of HFpEF. 