<prompt> Lactic acidosis in thiamine deficiency is due to which enzyme dysfunction?Phosphoenol pyruvate carboxykinasePyruvate dehydrogenasePyruvate carboxylaseAldolase  <response>: Ans. B. Pyruvate dehydrogenaseRef: Harper 31e page 138In Thiamine deficiency, PDH reaction is defective. So Pyruvate is converted to lactic acid.Causes of inhibition PDH leading to lactic acidosisInherited PDH deficiency.Thiamin deficiency.Alcoholics due to thiamine deficiency.Arsenite and Mercury poisoning. 