<prompt> A 17-year old male complains of recurrent episodes of cough, wheezing and shoness of breath paicularly at night for the last 3 days. His sibling has a history of similar symptoms. A Skin test with pollen produces immediate wheal and flare. The laboratory finding most consistent with his clinical findings would beNeutrophiliaCold agglutininsPositive direct antiglobulin testEosinophilia  <response>: Atopy is the major risk factor for asthma.Patients with asthma commonly suffer from other atopic diseases,paicularly allergic rhinitis and atopic dermatitis.Eosinophilic infiltration of airways along with peripheral eosinophilia is a characteristic feature seen in asthmatic patients.There will also be elevated total serum IgE and specific IgE to inhaled allergensradioallergosorbent test in atopic asthma. Ref:Harrisons medicine-18th edition,page no:2109. 