<prompt> Which of the following is the drug of choice for the treatment of inappropriate anti-diuretic hormone secretion:FrusemideHydrochlorothiazideSpironolactoneDemeclocycline  <response>: Answer is D Demeclocycline: The treatment of choice for S1APH is water restriction. The drug of choice for SIAPH when water restriction is unsuccessful is demeclocycline. Demeclocycline a tetracycline acts as an ADH antagonist. 