<prompt> USG abdomen of a 30-year-old SLE patient who cannot feel her baby moving for past 7 days. Earliest appearance of spalding sign is at3 days4 days6 days7 days  <response>: Image Courtesy- Case courtesy of A.Prof Frank Gaillard, Anti-phospholipid antibody syndrome explains the I.U.D The irregular overlapping of the cranial bones on one another- spalding sign is due to liquefaction of the brain matter and softening of the ligamentous structures supporting the vault. It usually appears 7 days after death. Similar features may be found in extra-uterine pregnancy with the foetus alive. 