<prompt> A patient presents with thrombocytopenia, eczema and recurrent infections. What is the most probable diagnosis?Wiskott Aldrich syndromeA beta gammaglobulinemiaChediak higashi syndromeLazy leukocyte syndrome  <response>: Wiskott-Aldrich syndrome WAS is an X-linked plateletimmunologic disorder caused by mutations in the WASP gene. The triad of eczema, recurrent infections, and microthrombocytopenia that characterizes WAS only occurs in 27 of the cases. The immunologic defects include low serum concentrations of IgM, while IgA and IgG are normal and IgE is frequently increased. Ref: The Elements of Immunology By Fahim Halim Khan, 2009, Page 413 ; Harrisons 17th ed chapter 310 