<prompt> Anticentromere antibodies are most commonly associated with:Diffuse cutaneous systemic sclerosisMixed connective tissue diseaseCREST syndromePolymyositis  <response>: Anti-centromere antibodies react with protein antigens located in the kinetochore region of chromosomes and are present in 40 to 80 of patients with limited cutaneous scleroderma or CREST syndrome. So CREST syndrome is the single best answer of choice. Ref: Harrisons Principles of Internal Medicine, 16th Edition, Pages 1979, 1986. 