<prompt> Gastro intestinal disturbance in cystic fibrosis are all EXCEPTSpleen infactBiliary cirrhosisMalabsorptionGall stones  <response>: A. i.e. Spleen infact 282,366 - Ghai 6th 1803 - Nelson I8thCYSTIC FIBROSIS Autosomal recessive, mutation affects the genes protein product cystic fibrosis trans membrane regulator CFTR which acts on chloride channelCLINICAL FEATURES- Intestinal obstruction may be the initial manifestation in the neonatal period Meconium ileus Two cardinal symptoms of the disease are chronic diarrhea with massive steatorrhoea and recurrent respiratory tract infections, bronchicetasis Failure to thrive is also a prominent features Rectal prolapse also occurs infrequently Biliary cirrhosis of liver is often observed oesophageal varices, Hypersplenism Malabsorption, insufficient or low bicarbonate with low ph in the intestine Increased secretion of chloride in the sweat 60 meqL is diagnostic Pancreatic insufficiency is present in 85 of CF With increasing age- azoospermia is observed in almost all patientsComplications of cystic fibrosisRespiratoryGITOthers Bronchiectasis, bronchitis bronchiolitis, pneumonia Atelectasis, Hempoptysis Pneumothorax, Nasal polyp.Sinusitis Reactive airway disease Cor pulmonale Respiratory failure Allergic broncho pulmonary aspergilosis Meconium ileus. Meconium plug and peritonitis Distal intestinal obstruction syndrome Rectal prolapse. Intussuception volvulus. Fibrosing colonopathy stricture. Appendicitis pancreatitis, Cholelithiasis, Inguinal hernia Vitamin deficiency states A.K.E.D Infertility DM Amyloidosis Dehydration heat exhaustion Hypertrophic osteoarthropathy- arthritis. Clubbing Delayed puberty 