<prompt> A patient presented with colon type diarrhea with blood. On sigmoidoscopy, cauliflower mass found and excised. On genetic analysis of mass, which does not have prognostic calue?KransC mycMicrosatallite instabillityerbB2  <response>: in gastric carcinoma ,.E cadherin gene mutation in diffuse cancers Mutation in APC gene for b-catenin in intestinal , cancers - 50 - Inactivation tumour supsamines, lead pressor gene p53 in 30 Loss of heterozygosity in the BCL2 gene, an inhibitor of apoptosis intestinal - distal type cancers HNPCC - Carries 5-10 H. pylori infection, chronic risk of gastric cancer gastritis Li Fraumen syndrome Pernicious anaemia Blood group A Intestinal metaplasia First degree relative carries FAP - 10 folds more risk of gastric cancer Mutation of H-ras oncogene and over expression of c-erb B2 gene ref:SRB;s manual of surgery ,ed 3,pg no779 