<prompt> The most common agent causing osteomyelitis in sickle cell disease patients?Salmonella enteritidisE.coliKlebsiellaEnterococcus  <response>: Salmonella Subspecies other than typhi S. enteritidis, S. typhimuriumFacultative gram-negative rods, non-lactose-fermenting on EMB, MacConkey medium Produces H2S, motile unlike Shigella Speciated with biochemical reactions and serotyped with O, H, and Vi antigensDiseases: Enterocolitisgastroenteritis second most common bacterial cause after Campylobacter: 6- 48-hour incubation; nausea; vomiting; only occasionally bloody, loose stools; fever; abdominal pain; myalgia; headache Septicemia S. enterica subsp. choleraesuis, S. enterica subsp. paratyphi, and S. enterica subsp. dublin: usually in very young or elderly when it occurs; endocarditis or ahritis complicates 10 of cases Osteomyelitis: sickle cell disease predisposes to osteomyelitis; Salmonella is most common causal agent of osteomyelitis in sickle cell disease not trait patients 80.Ref: Ananthanarayan; 7th edition; Page no: 303 