<prompt> Female presents with history of color change from pallor to cyanosis on exposure to cold in fingers. This condition is mostly associated with ?SclerodermaLeukemiaLung infectionsHepatosplenomegaly  <response>: History of color change from pallor to cynosis on cold exposure suggests raynauds phenomenon. Raynauds phenomenon is the most common and earliest manifestation of generalized scleroderma systemic sclerosis. 