<prompt> Significant weight loss is -5 over 6-12 months10 over 6-12 months5 over 6 weeks10 over 6 weeks  <response>: Ans. is a i.e., 5 over 6-12 months o Clinically important weight loss is defined as the loss of 10 pounds 4.5 kg or 5 of ones body weight over a period of 6-12 months. 