<prompt> In tuberculosis, the cytokine playing major role in the conversion of tissue macrophages in to epithelloid cells -Interferon gammaTumor necrosis factorInterleukin 12Macrophage chemoattractant protein  <response>: IFNg is an impoant activator of macrophages Reff : Ananthanarayan Panikers textbook of microbiology 9th edition pg: 155. 