<prompt> The TRUE statement about B cell Prolymphocytic leukemia is:The median age is 40Generalised lymphadenopathy is the presenting symptomThe cell express surface IgM and CD19,20,22Splenectomy improves the survival  <response>: B Cell Prolymphocytic Leukemia Malignancy of medium-sized, round lymphocytes with a prominent nucleolus and light blue cytoplasm It usually does not cause adenopathy. The median age of patients is 70 years The clinical course can be rapid. The cells express surface IgM and B cell markers CD19, CD20, CD22. CD23 is absent. Fludarabine and cladribine and combination chemotherapy cyclophosphamide, doxorubicin, vincristine, prednisone, or CHOP are effective. Splenectomy can produce palliation of symptoms but little impact on the course of the disease. Ref: Harrison, E-18, e-21. 