<prompt> Intrinsic cell wall defect of RBCs is feature of -Paroxysmal nocturnal hemoglobinuriaSickle cell anemiaHemophiliaAll of the above  <response>: Paroxysmal nocturnal hemoglobinuria is a disease that results from acquired mutations in the phosphatidylinositol glycan complementation group A gene PIGA, an enzyme that is essential for the synthesis of ceain membrane associated complement regulatory proteins. Ref :Robbins pathologic basis of disease ; south east asia edition ;pg:642 