<prompt> Prostate cancer is best diagnosed by?Prostate specific antigenTrans urethral ultra soundFNAC of prostate glandDRE  <response>: 3D Trans-Urethral Ultrasound TUUS is a new technique for the diagnosis and treatment of prostate disease. TUUS provides real-time, high resolution images of the prostate. Because of the central location of urethra, the TUUS devices can use higher frequency than transreactal ultrasound TRUS, since there is less tissue to traverse to the prostate borders. TUUS can be used as a therapy guidance tool during and after transperineal interstitial permanent prostate brachytherapy. PSA prostatic specific antigens are a good tool for screening the prostatic cancers, but definitive diagnosis is obtained by biopsy. They are neither sensitive nor specific. 