<prompt> Cryosurgery is used in treatment of cervical intraepithelial neoplasia. It is appropriate in all exceptTransformation zone lying entirely on ectocervix.Smooth cervical surface without deep crevices.Cervical intraepithelial neoplasia -3.CIN limited to two quadrants of the cervix.  <response>: Cryosurgery is generally not favoured for treatment of CIN-3 due to higher rates of disease persistence following treatment, and lack of histologic specimen to exclude occult invasive cancer. 