<prompt> A male baby was born in a hospital. After 12 hr of bih, baby was found to be pale. His serum total billirubin level was 20 mgdl and unconjugated bilirubin was 15 mgdl, after 36 hr of bih, Hemoglobin was 14 gdl, and reticulocyte count was high. On peripheral smear, nucleated RBCs and spherocytes are seen. Best possible diagnosis is?Pyruvate kinase deficiencySickle cell anemiaHereditary spherocytosisRh incompatibility  <response>: As the neonate has unconjugated hyperbilirubinemia along with high reticulocyte count, he seems to be having haemolytic anemia. Spherocytes are seen in Hypehermia Hereditary spherocytosis G6PD deficiency ABO incompatibility Hereditary spherocytosis is one of the most common reason for Neonatal hyperbilirubinemia along with G6PD deficiency Diagnosis of hereditary spherocytosis is usually based on:- Positive Family history not mentioned in this case Splenomegaly Uncommon in neonates Spherocytes on Peripheral smear Reticulocytosis Elevated MCHC Increased Osmotic Fragility 