<prompt> A child with pellagra like symptoms,amino acids in urine,family history of two siblings normal and two affected.Parents are normal.What is the diagnosis?PKUAlkaptonuriaMSUDHanups disease  <response>: Hanups disease : disease is caused by a mutationsix mutations in SLC6A19 of the gene that controls the processes of amino acid absorption and reabsorption. Symptoms: sensitivity to light anxiety rapid mood swings hallucinations delusions intention tremor speech difficulties abnormalities in muscle tone: either muscles can become more tight DIAGNOSIS: Blood Test Urine Test Prenatal Screening Based On the Symptoms Treatment: consists of a change in diet, avoidance of sunlight, and prescribing sulfonamide drugs Consuming foods that contain the B-complex vitamin niacin can significantly reduce your symptoms. Good sources of niacin include: meat poultry fish foified and whole grains peanut butter potatoes B-complex or niacin vitamin supplements such as nicatonic acid Reference: Harpers illustrated biochemistry 30th edition 