<prompt> Imipenem is combined with cilastatin toCilastatin prevents degradation of imipenem in kidneyCilastatin inreases intestinal absorption of imipenemCilastatin inhibits beta lactamase activityBoth have synergistic activity against Pseudomonas  <response>: Imipenems rapidly inactivated by renal dehydropeptidase I, so it is combined with cilastatin, an inhibitor of this enzyme. Cilastatin, a reversible inhibitor of dehydropeptidase, increases the half life of imipenem and also inhibits the formation of nephrotoxic metabolite. Meropenem, doripenem and eapenemare not metabolized by renal dehydropeptidase 