<prompt> Neoplasm associated with Waldenstorms macro- globulinemia also called as:Smoldering myelomaPrimary CNS lymphomaLympho plasmacytic lymphomaMGUS Mono gammopathy of undetermined significance  <response>: Ref: Harrisons Principles of Internal Medicine, 18th edition, pg 942, 943, 940, 3387Explanation:Waldenstorms macroglohulinemia is a malignancy of lymphoplamsmacytoid cells that secrete IgMAssociated with lymphadenopathy, hepatosplenomegaly, hy perv i scos styNo bony lesionsrenal disease like IgM myelomaElderly agePeripheral neuropathy. anti-MAG Myelin associated glycoprotein antibody positiveCryoglobulins positive in some. CD 138Treatment- Plasmapheresis for hyperviscosity, fludarabine, cladrihine. rituximab. lenalidomide. bortezomib. bendamustineSmoldering myeloma:Serum M protein 30gL bone marrow plasma cells 10No myeloma related organ damageNo treatment neededMay progress to multiple myelomMGUS:M protein 30gLBone marrow plasma cells 10No bony lesions or target tissue damage CRAB- Hypercalcemia, renal failure, anemia, bony lesions25 may transform into multiple myeloma 1 per yrPrimary CNS lymphoma:Type of non -Hodgkins lymphoma large B- cellSeen commonly in HIV patients; CD4 50Associated w ith EBVDiffuse enhancing lesion on contrast CTT real men t-met ho trxate .Chemotherapy. radiotherapy, rituximab, HAART 