<prompt> In DM type-II Insulin resistance develops due toEnd organ target receptor insensitivityDKAHONK Hyperosmolar nonketosisGenetic  <response>: Ans. a End organ target receptor insensitivity. Ref. Harrison, Principles of Medicine, 18th2109DIABETES MELLITUSType 2 DM is usually characterized bya Variable degree of insulin resistanceb Impaired insulin secretionc Increased glucose production The distinct pathologic processes are end organ target receptor insensitivity and a genetic and metabolic defect in insulin secretion and action. Amyloidosis of pancreas is also a cause. Type 1A DM results from autoimmune beta-cell destruction has tendency to develop ketosis While in Type IB DM the mechanism of destruction is not known. 