<prompt> MRP2 transpoer defect leads to development of?Menkes diseaseDubin Johnson syndromeFamilial intrahepatic cholestasisBenign recurrent intrahepatic cholestasis  <response>: MRP2 defect: Multidrug resistance-associated protein 2 MRP2, an ATP-dependent canalicular membrane transpoer. It is defective in Dubin Johnson syndrome. This protein is encoded by gene known as ABCC2 Gene which is mutated. Dubin Johnson syndrome- It is an autosomal recessive disorder occurs due to defect in MRP-2 protein. kernicterus is absent , with liver biopsy showing black pigmentation. Mild jaundice is seen with normal bile acids level. 