<prompt> Kallmans syndrome is associated with all of the following except-amenorrheaexcess stimulation of the HPO axisgenetic mutationanosmia  <response>: Ans. is b i.e., excess stimulation of the HPO axis Kallmanns Syndrome:o When congenital GnRH deficiency is associated with anosmia or hyposmia an absent or grossly impaired sense of smell, the disorder is known as Kallmanns syndrome.o Two genetic mutations associated with Kallmans Syndrome :a KAL gene - X - linked inheritance Xp22?3 encoding anosmin - 1.b Gene encoding FGFR1 Fibroblast growth factor - 1 receptor - autosomal dominant form.o Anosmin - 1 is a neural adhesion molecule that promotes migration of GnRH neurons and olfactory neurons, from the olfactory placode into the hypothalamus during embryonic developmento At puberty, both males and females with Kallmanns syndrome usually present with delayed growth and sexual development.o The presence of pubic hair, reflecting a normal adrenarche, helps to distinguish them from those with a constitutional delay of puberty in whom adrenarche typically also is delayedo The disorder is also associated with cleft lippalate, urogenital tract anomalies, or syndactyly. 