<prompt> Thioamide drugs:Aggregate endocrine exophthalmos.Are safe in children.Produce irreversible hypothyroidism.Do not produce relapse.  <response>: Thioamide drugs block the synthesis of thyroid hormones and are safe in children. If hypothyroidism develops, stopping the drug can reverse it. Despite adequate treatment, relapse is seen in 40-60 of the cases. Worsening of ophthalmopathy has been reported with radioactive iodine but not with thioamides. 