<prompt> Basic lesion in tobacco amblyopia islschaemia of optic nerve fibresDegeneration of ganglion cells especially of macular regionDegeneration of foveal conesAll of the above  <response>: Tobacco amblyopia It typically occurs in men who are generally pipe smokers, heavy drinkers and have a diet deficient in proteins and vitamin B complex; and thence also labelled as tobacco-alcohol-amblyopia. Pathogenesis: The toxic agent involved is cyanide found in tobacco. Ref:- A K KHURANA; pg num:-296 