<prompt> Apatient who is at risk of estrogen dependent carcinoma and hence estrogen is contraindicated. So in order to prevent vasomotor symptoms, which drug is given?TamoxifenConjugated estrogenClonidineYombinine  <response>: Clonidine REF: Novaks gynecology 13th edition page 455 In women for whom hormone replacement is contraindicated, multiple alternative treatments for hot flashes have been developed. Somewhat effective alternatives may be progestins such as medroxyprogesterone 10 to 30 mg daily orally or megestrol acetate 20 to 40 mg daily orally. If either of these progestins results in intolerable side effects, the use of alternative progestins may be considered, although few data exist regarding their efficacy. In addition to the progestins, other nonsteroidal treatments for hot flashes have been developed. One of the best studied is the b 2-adrenergic agonist, clonidine. This drug probably works through both central and peripheral mechanisms and can be given either orally 0.05 mg twice daily or by transdermal patch. 