<prompt> Fluconazole different from ketoconazole in thatIt is not active by the oral routeIt is more potent inhibitor of drug metabolismIt is not effective in Cryptococcal meningitisIt is unlikely to produce anti androgenic side effects  <response>: REF-KDT6e p762 Ketoconazole is rarely used now a days because of several limitations. Impoant among them are: Poor oral bioavailability Limited CNS penetration Powerful inhibition of microsomal enzymes Anti-androgenic adverse effects like gynaecomastia Fluconazole is preferred agent because it has Very good oral absorption Maximum CNS penetration therefore effective in cryptococcal meningitis. No inhibitorv action on microsomal enzymes No anti-androgenic propey. 