<prompt> Mutation of which of the following gene is most impoant in paroxysmal nocturnal hemaglobinuria?Decay accelerating factor DAFMembrane inhibitor of reactive lysis MIRLGlycosyl phosphatidyl inositol GPICD8 binding protein  <response>: Ans. is c Glycosyl phosphatidylinositol o PNH results from acquired mutation that inhibits the synthesis of Glycosyl-phosphatidyl-inositol GPI. o The GPI linked proteins that are missing are membrane inhibitors of reactive lysis MIRL; CD59, delay accelerating factor DAF; CD55, C8 binding protein, urokinase plasminogen activator receptor, leukocyte alkaline phosphatase LAP. 