<prompt> Reed-Steinberg cells of Hodgkins disease positive for CD15 CD30 are seen in all types EXCEPT :Nodular sclerosisMixed cellularityLymphocyte depletionLymphocyte predominance  <response>: Ans. d Lymphocyte predominance. Robbin, Pathologic Basis of Diseases, 6th611HODGKINS DISEASE HD - subtypesSUBTYPES OF HODGKINSFEATURESNodular sclerosis 65-75 Best prognosis Most common worldwide Lacunar cells Diagnostic RS cells Fibrous collagen Bands dividing cellular areas into nodules. RS cells CD15, CD30Mixed cellularity 25 Plenty of classic RS cells and mononuclear variants CD15, CD30 RS cells. Most common in India.Lymphocyte predominance 6 Lymphohistiocytic variants Popcorn cells, RS cells CD20, CD15- , CD30-Lymphocyte depletion 3-5 Worst prognosis Rare CD15, CD30. Reticular variants Controversial entity. 