<prompt> E cadherin gene deficiency is seen in:Gastric cancerIntestinal cancerThyroid cancerPancreatic cancer  <response>: Cadherin is derived from the calcium-dependent adherence protein. It participates in interactions between cells of the same type. The linkage of cadherins with the cytoskeleton occurs through the catenins. The cell-to-cell interactions mediated by cadherin and catenins play a major role in regulating cell motility, proliferation, and differentiation and account for the inhibition of cell proliferation that occurs when cultured normal cells contact each other contact inhibition.Reduced function of E-cadherin is associated with certain types of breast and gastric cancer. Mutation and altered expression of the Wntβ-catenin pathway are implicated in gastrointestinal and liver cancer development. 