<prompt> Mechanism of action of paclitaxel is -Topoisomerase inhibitionIncreases the polymerization of tubulinInhibits protein synthesisAlkylation of DNA  <response>: Ans. is b i.e., Increases the polymerization of tubulin o Paclitaxel and docetaxel function as a mitotic spindle poison through high affinity binding to microtubules with enhancement of tubulin polymerization. o The microtubules are stabilized and their depolymerization is prevented inhibition of mitosis and cell division. 