<prompt> Anaphylaxis refers to the:Severe reaction following the injection of protein solutions in a sensitised individualSevere reaction following primary injection of protein solutionsState of immunity developed by repeated injections of any foreign substanceSevere reaction resulting from sensitivity to common allergens  <response>: Prince of Monaco first observed the deleterious effects of jellyfish on bathers. Subsequently, Portier and Richet 1906 suggested a toxin to be responsible for these effects and coined the term anaphylaxis.Initiator cells in anaphylaxisThe initiator of type I reaction is otherwise known as allergen.Typical allergens include:Plant pollenProteins e.g., foreign serum and vaccinesCertain food items e.g., eggs, milk, seafood, and nutsDrugs e.g., penicillin and local anestheticsInsect products venom from bees, wasps, and antsDust mites and mould sporesAnimal hair DanderParija SC. Textbook of Microbiology Immunology. Elsevier Health Sciences; 2014. Page:149-150 