<prompt> 20-year-old swimmer who has been in excellent health and takes no chronic medications, for new-onset severe fatigue and left upper abdominal pain. She was treated 2 days ago in hospital for presumed typhoid with cefotaxime. She also had past ho typhoid in 2 yrs back. On physical examination her hea rate of 120 bpm and a palpable spleen. Stool is negative for heme. Lab investigations shows hemoglobin of 5 gdL with normal TLC and platelets. Peripheral blood smear reveals an excess of spherocytes. All of the following can cause similar type of this condition except:SLEa - Methyldopa ingestionQuinidineInfectious mononucleosis  <response>: Patient is having autoimmune hemolytic anemia AIHA due to development of warm immunoglobulin G IgG antibodies due to cefotaxime exposure Warm antibody hemolytic anemia- most common form of autoimmune hemolytic anemia AIHA. Autoantibodies generally react at temperatures 37deg C. Most of the autoantibodies are IgG. Hemolysis occurs primarily in the spleen. The autoantibodies may occur: 1.Spontaneous 2.SLE, lymphoma,CLL 3. Drugs- alpha -methyldopa, high-dose penicillin, cephalosporins 