<prompt> Multidrug-resistant S. typhi are resistant to all except-ChloramphenicolAmpicillinCiprofloxacinSeptran  <response>: Isolates of S. typhi resistant to chloramphenicol, ampicillin, and co-trimoxazole designated as multidrug-resistant S. typhi . Ciprofloxacin became drug of choice for typhoid fever in patients of all age groups, infected or likely to be infected with fully drug susceptible S. typhi or MDR-ST. Alternative : Third-generation cephalosporins cefixime for 7 to 14 days or ceftriaxone for 10 to 14 days and azithromycin for 7 days. 