<prompt> A child presented with anemia, kinky hair, intellectual disability and seizures. Which of the following is the most likely diagnosis?Menkes diseaseDown syndromeIron deficiency anemiaLesch Nyhan syndrome  <response>: a. Menkes diseaseRef: Nelson 20e p 1849Menke disease is a X-linked recessive multisystem disorder that mainly involves CNS usually presents in early infancy. Scalp hair become hypopigmented, sparse, short, and brittle. Hair microscopy reveals pili torti twisted hair trichorrhexis nodosa fractures of the hair shaft at regular intervals. 