<prompt> The primary role of chaperones is to help inProtein synthesisProtein degradationProtein denaturationProtein folding  <response>: Proteins must fold to achieve their functional form. Folding can be spontaneous or facilitated by chaperones. Proteins that are defective for example misfolded or destined for rapid turnover are marked for destruction by the attachment of chains of a small, highly conserved protein called ubiquitin. Ubiquitinated proteins are rapidly degraded by a cytosolic complex known as the proteasome. Reference: Lippincotts illustrated reviews of Biochemistry Sixth edition: page no; 807 