<prompt> Young female presents with hypeension with VMA 14 mgday, associated with -a Medullary Ca Thyroidb Von Hippel Lindau diseasec Sturge weber syndromed Graves diseasee Neurofibromatosisbcdabcacdeabce  <response>: Biochemical tests for pheochromocytoma Most sensitive screening test : Urinary catecholamines and VMA levels Best diagnostic test : Fractionated plasma metanephrines Pharmacological tests Positive response to phentolamine is reduction of BP of atleast 3525 mmHg after 2 min. It is not a diagnostic and biochemical confirmation Glucagon infusion increases catecholamines release and causes paroxysm of hypeension She is suspected of having pheochromocytoma Syndromes associated with pheochromocytoma MVVS MEN-2A MEN-2B VHL syndrome Von-Recklinghausen syndrome Struge-weber syndrome Ref: schwazs principle of surgery 10th edition Pgno :1586 