<prompt> True about Wilsons diseaseDecreased urinary excretion of copperIncreased ceruloplasmin in bloodDecreased copper and ceruloplasmin in serumDecreased urinary excretion of ceruloplasmin  <response>: In Wilsons disease, there is almost always a failure of synthesis of ceruloplasmin; however, some 5 of patients have a normal circulating ceruloplasmin concentration and this is not the primary pathogenic defect. The amount of copper in the body at birth is normal but thereafter it increases steadily; the organs most affected are the liver, basal ganglia of the brain, eyes, kidneys and skeleton. 