<prompt> Anti-double stranded DNA is highly specific for :Systemic sclerosisS.L.E.PolymyositisRheumatic sclerosis  <response>: Ans. is b SLE Ref: Chandrasoma Taylor, 3e, p 985, Harrison 17e p 2079 16e, p 1971.Anti-double stranded DNA is specific for SLE, anti-single stranded DNA is not specific.Also remember Anti-Smith Anti Sm is also specific for SLE and is found in 30 cases of SLE.Anti-histone antibody is specific for drug induced SLE. 