<prompt> Which of the are the following contraindication for halothane usedMale sexMiddle ageRecent halothane useAssociated liver pathology  <response>: Multiple exposures is the single most important factor for halothane hepatitis Repeated use should be avoided, at least an interval of 3 months should be given between two exposures.Obesity and middle age are risk factors for halothane hepatitis, but these are not contraindications.Option d requires specific mention here :- Pre-existing liver disease or jaundice is not a contraindication :-There is no compelling evidence associating halothane with worsening of pre-existing liver disease.__ Morgan 4the 169Pre-existing liver disease unrelated to halothane is not a contraindication to the use of halothane.__ Lee 13the 143Liver dysfunction Jaundice to previous halothane exposure is a contraindication. Though not a contraindication, Halothane should be avoided in liver disease. 