<prompt> Antibodies to calcium channel are seen in -Eaton lambert syndromeDermatomyositisMvaesthenia gravisPolymyositis  <response>: Ans. is a i.e., Eaton lamberi syndrome Lambert Eaton Mvesthenic syndromeo It is a paraneoplastic syndrome associated with small cell cancer of lung.o It is a disorder of neuromuscular junction transmission presynaptic.Pathogenesis : -o Autoantibodies are present against voltage sensitive calcium channels.These IgG autoantibodies against voltage sensitive calcium channels reduce the number of functioning channels. 773 is causes decrease in release of presynaptic acetylcholine.Difference between Myaesthenia Gravis Eaton Lambert SyndromeMyaesthenia GravisEaton Lambert Syndromeo Postsynaptic Q defect Autoantibodies direct against acetyle choline receptorso Decrease in number of acetylcholine receptors0 at post synaptic muscle membraneMuscular involvemento Occular muscle is most Q commonly involvedo Occular muscle proximolQ limb musclso Tendon reflexes ate intact Qo No autonomic changes Qo Presynaptic Q defecto Antibodies directed against PQ typeo of calcium channelso Decrease in presynaptic release of acetylcholine QMuscular involvemento Proximal muscles of lower limb Qo are most commonly involvedo Proximal muscles occular Q muscleso Tendon reflexes are depressed or absent Qo Slow autonomic changes such as dry Q mouth and impotenceDiagnosisDiagnosiso DecrementalQ response on repeated nerve stimulationo Antibody against acetylcholine receptoro IncrementalQ response on repeated nerveo stimulationo Antibody against PQ channel 