<prompt> Myasthenia gravis is most commonly associated with which of the following?ThymomaThymic carcinomaThymic hyperplasiaLymphoma  <response>: Myasthenia gravis Autoimmune disease with fluctuating muscle weakness that is caused by autoantibodies that target the neuromuscular junction. About 85 of patients have autoantibodies against post-synaptic ACh receptors, while most of the remaining patients have antibodies against the sarcolemmal protein muscle-specific receptor tyrosine kinase. CF: - Ptosis or diplopia Weakness in extraocular muscle There is a strong association between pathogenic anti-ACh receptor autoantibodies and thymic abnormalities. Approximately 10 of patients with myasthenia gravis have a thymoma, a tumour of thymic epithelial cells. An additional 30 of patients and paicularly young patients have a different thymic abnormality called thymic hyperplasia. Acetylcholinesterase inhibitors that increase the half-life of ACh are the first line of treatment. 