<prompt> Which of the following syndromes is best associated with congenital heart disease?Lesch-Nyhan syndromeRasmussen syndromeHolt-Oram syndromeLeopard syndrome  <response>: c. Holt-Oram syndromeRef: Nelsons 20e p 746, Ghai 8e p 413Discussing about the options one by one,Name of the syndromeClinical featuresa. Lesch-Nyhan syndromeHyperuricemia, intellectual disability, dystonia, choreoathetosis, spasticity, dysarthric speech and compulsive self-biting, usually beginning with eruption of teethb. Rasumussen syndromeIt is an immune mediated disease associated with intractable unilateral seizures, progressive hemiparesis and intellectual dysfunctionc. Holt-Oram syndromeASD bony abnormalities, with a strong familial tendency autosomal dominant inheritanced. LEOPARD syndromeLentigines multiple, Electrocardiographic conduction abnormalities, Ocular hypertelorism, Pulmonary stenosis, Abnormalities of genitalia, Retardation of growth, Deafness 