<prompt> Which of the following is the hallmark of chronic renal failure?Metabolic acidosisHypercalcemiaHypokalemiaIncreased proneness to hypoxia  <response>: Metabolic acidosis Ref: Robbins 7th EdPg 961 Manifestations of chronic renal failure: I. Fluid electrolyte 1. Dehydration 2. Edema 3. Hyperkalemia 4. Metabolic acidosis II. Calcium, Phosphate, bone 1. Hyperphosphatemia 2. Hypocalcaemia 3. Secondary hyperparathyroidism 4. Renal osteodystrophy III. Hematologic 1. Anemia 2. Bleeding disorders IV. Neuromuscular 1. Myopathy 2. Peripheral neuropathy 3. Encephalopathy V. Dermatological 1. Yellow colour 2. Pruritis 3. Dermatitis 