<prompt> False about protease inhibitors in HIV is -They are powerful enzyme inhibitorsOf all the protease inhibitors saquinavir is the most powerful inhibitor of CYP3A4They cause hepatotoxicityAll protease inhibitors are substrates for P glycoprotein coded by MDR gene.  <response>: Ans. is b i.e., Of all protease inhibitors saquinavir is the most powerful inhibitor of CYP3A4 Saquinavir is a weak inhibitor of CYP3A4. About other options All protease inhibitors especially ritonavir and lopinavir are potent inhibitors of CYP3A4 - Ritonavir has the most pronounced inhibitory effect, while saquinavir has the least. o Most HIV protease inhibitors are substrates for P-glycoprotein drug transpoer P-gp, which is an efflux pump encoded by the mdr 1 gene. Goodman Gilman 1 lthe 1297 Indinavir and atazanavir can cause indirect hyperbilirubinemias with ove jaundice. 