<prompt> Sabin Feldman exclusion test is used for diagnosis of:SyphilisLeptospirosisToxoplasmosisMultiple myeloma  <response>: Ans. c Toxoplasmosis. Ref. Harrisons medicine 16th ed. 1243TOXOPLASMOSIS Sabin-Feldman dye test is for trophozoites of Toxoplasma gondii. IgG antibodies are primarily measured by the Sabin-Feldman Dye Test DT. The DT is a sensitive and specific neutralization test in which live organisms are lysed in the presence of complement and the patients IgG T. gondii-specific antibody. IgG antibodies usually appear within 1 to 2 weeks of the infection, peak within 1 to 2 months, fall at variable rates, and usually persist for life. The titer does not correlate with the severity of illness. A positive DT establishes that the patient has been exposed to the parasite. A negative DT essentially rules out prior exposure to T. gondii unless the patient is hypogammaglobulinemic. In addition, rare cases of toxoplasmic chorioretinitis and TE toxoplasmic encephalitis in immunocompromised patients have been documented in patients negative for T. gondii-specific IgG antibodies. Rx: Sulfadiazine pyrimethamine. 