<prompt> All are true about losaan, except ?Angiotensin II antagonistCauses hyperuricemiaDoes not cause coughLong acting metabolites  <response>: Ans. is b i.e., Causes hyperuricemia Losaan is a mild uricosuric agent, Le causes hypouricemia o Losaan is a competitive antagonist of angiotensin II 10000 times more selective for AT! than AT2. o In liver it gets conveed to long acting metabolite E 3174 which is 10-30 times more potent non competitive antagonist of AT1 o Plasma t 2 of i Losaan --- 2hr ii E3174 -- 6-9 hrs. o It has several advantages over ACE inhibitors It does not cause cough and angiodema It does not cause dysguesia altered taste sensation It does not cause first dose hypotension AT-11 antagonists are more effective than ACE inhibitors in blocking the vasopressor action of angiotension-IL Similarities with ACE inhibitor 3 Hyperkalemia and, hypotension 3 Teratogenic Contraindicated in pregnancy Why do AT-II antagonists not cause cough and angiodema, while ACE inhibitors do ? Lets see Bradykinin and sustance P are substrate for ACE. ACE inhibitors increase level of these kinins by inhibiting ACE, which is responsible for cough and angiodema. AT-II antagonists do not inhibit ACE they block AT-II recepotors -- No increase in the level of bradykinin and subustance P -- No cough angiodema. 