<prompt> Which is not a feature of neoplastic cell?HyperchromasiaPleomorphismAtypical mitosesNuclear cytoplasmic ratio 1:4  <response>: Ans: d Nuclear cytoplasmic ratio 1:4The hallmark of malignant transformation is anaplasia.The morphological changes in anaplasia are:-1 Pleomorphism: by both cell nuclei2 Abnormal nuclear morphology: HyperchromasiaNuclear cytoplasmic ratio approaches 1:1 normal is 1:4 or 1:6Large nucleoli3 Large no of mitoses4 Loss of polarity5 Other changes: tumour giant cells 