<prompt> Which of the following anesthetic agent may have cerebroprotective affect :BarbituratesKetamineEtomidateAll show cerebroprotective effect  <response>: CBF ICP CMRO2 Thiopentone Ketamine etomidate propofol ketamine also has antiemetic effect through NMDA receptor. It also has cerebroprotective effect. JOURNAL : Ketamine is said to increase intracranial pressure ICP, cerebral blood flow CBF and cerebral metabolic rate for oxygen CMRO2 and hence to be unsuitable for neuroanaesthesia. This may require reconsideration in the light of the neuroprotective propeies mediated by the interaction of ketamine with the N-methyl-D-aspaate receptor NMDA. 