<prompt> Which of the following syndrome is most commonly associated with clefts of lip and palateApert syndromeCrouzon syndromePierre-Robin syndromeDowns syndrome  <response>: Although most clefts of the lip and palate occur as an isolated deformity, Pierre Robin sequence remains the most common syndrome.This syndrome comprises of isolated cleft palate, retrognathia and a posteriorly displaced tongue glossoptosis, which is associated with early respiratory and feeding difficulties. 