<prompt> Which antigen is not of prognostic significance in carcinoma breastHer 2 neuEpithelial membrane antigenERPR  <response>: The presence of hormone receptors confers a slightly better prognosis.The highest rate of response approximately 80 to antiestrogen therapy oophorectomy or tamoxifen is seen in women whose tumor cells express both estrogen and progesterone receptors Overexpression of HER2NEU:Overexpression of this membrane-bound protein is almost always caused by gene amplification ref : Robbins Basic Pathology, 9E,page-713 