<prompt> Ankylosing spondylitis in associated with:HLA-B27HLA-B47HLA-DW4DR4HLA-DR3  <response>: SERONEGATIVE SPONDYLOAHROPATHIES Feature HLA B-27 positivepresence of uveitis Onset usually before 45 years age Inflammatory ahritis of spinelarge peripheral joints Absence of autoantibodies e.g. rheumatoid factor in serum so known as seronegative -Other diseases associated with HLA-B27 positivity Mnemonic: PEARS HLA-B27 Positive P- Psoriatic ahritis E- Enteropathic ahritis A- Ankylosing spondylitis90 R- Reiters syndrome Reactive ahritis S- SAPHO Syndrome OTHER OPTIONS: HLA-DW4DR4- AW rheumatoid ahritis. HLA-DR3 - AW Type 1 diabetes mellitus HLA-B47- AW 21 hydroxylase deficiency 