<prompt> Which gene is most commonly mutated in autosomal dominant polycystic kidney disease ADPKD?PKD1PKD2NHPS1HEF  <response>: PKD1 gene codes for polycystin-1 and is located on chromosome 16p13.3. Polycystin-1 is expressed in tubular epithelial cells, paicularly those of the distal nephron. It contains domains that are usually involved in cell-cell and cell-matrix interactions. Mutations in PKD1 account for about 85 of cases. Numerous small cysts in the coex and medulla give the kidney a spongelike appearance. Cysts have a uniform lining of cuboidal cells. Multiple epithelium-lined liver cysts are also seen. 