<prompt> Which Anti-viral drug causes the below given condition :EntecavirAbacavirAdefovirNelfinavir  <response>: PROTEASE INHIBITORS - These drugs have adverse effects on Fat metabolism and redistribution on prolonged intake resulting in LIPODYSTROPHY SYNDROME Buffalo hump appearance , central obesity , metabolic syndrome etc These drugs cause LIPODYSTROPHY SYNDROME by - GLUCOSE LIPIDS INSULIN RESISTANCE WT. GAIN. - These include drugs like: INDINAVIR RITONAVIR LOPINAVIR AMPRENAVIR FOS-AMPRENAVIR ATAZANAVIR Lowest risk of Lipodystrophy syndrome but can cause hyperbilrubinemia SAQUINAVIR NELFINAVIR Abacavir, Entecavir and Adefovir - NI Nucleoside reverse transcriptase inhibitors 