<prompt> Which of the follwoing is TRUE about free water clearance?Regulated by ADHRegulated by aldosteroneIncreased by furosemideNone of the above  <response>: Free water clearance CH2O is the difference between the urine volume and the clearance of osmoles COsm. The excretion or retention of electrolyte-free water by the kidney is modulated by circulating vasopressin ADH. ADH acts on renal V2-type receptors in the thick ascending limb of Henle and principal cells of the collecting duct CD, increasing cyclic adenosine monophosphate AMP and activating protein kinase A PKA-dependent phosphorylation of multiple transpo proteins. Ref: Mount D.B. 2012. Chapter 45. Fluid and Electrolyte Disturbances. In D.L. Longo, A.S. Fauci, D.L. Kasper, S.L. Hauser, J.L. Jameson, J. Loscalzo Eds, Harrisons Principles of Internal Medicine, 18e. 