<prompt> Ivabradine is used for management of ?Stable anginaPre renal azotemiaAlzheimers diseaseAnti smoking agent  <response>: Ans. is a i.e., Stable anginaRef: KDT Vhe p. 554; Cardiac drug development guide by Micheal Pugsley p. 381IvabradineIt is an investigational inhibitor ofsino-atrial node.It is a relatively selective Iffunny current Sodium channel blocker of early pa of slow diastolic depolarization phase 4 that reduces hea rate by inhibiting the hyperpolarization-activated sodium channel in SA node.Hea rate is a major determinant of angina in coronary disease.Therefore, lowering the hea rate is an impoant therapeutic approach in the treatment of stable angina. 