<prompt> The immunosuppressant action of cyclosporin appears to be due toActivation of NK cellsBlockade of tissue response to inflammatory mediatorsInhibition of Gene transcription of interleukinInterference with antigen recognition  <response>: Ref-KDT 6e p838,839,840 Cyclosporine and tacrolimus acts by inhibiting calcineurin, which is involved in the activation of NFAT. Final result of this process is increased transcription of IL-2 gene. Sirolimus does not inhibit the transcription of IL-2 but interferes with its action. It inhibits the enzyme tyrosine kinase, known as mTOR which is activated by IL-2. 