<prompt> Cytokine causing fever -IL-6IFN-yIL-18EL-4  <response>: Ans. is a i.e., IL-6 Pyrogeneso Pyrogenes are substances that cause fever,o Pyrogens may be exogenous or endogenousExogenous - Bacterial toxinsEndogenous - IL-1, TNF-a, IL-6, Interferons, Ciliorys neurotropic factoro These pyrogenes increase the level of PGE2 in the hypothalamus that elevates the thermoregulatory set point and causes fever. 