<prompt> Longest acting beta blokeris -NodalolEsmololCarvedilolAcebnolol  <response>: Ans. is a i.e., Nodalol o Nodalol is longest acting b-blocker.o Esmolol is shortest acting b-blocker.Remembero Nodalol is longest acting b-blocker:o Esmolol is shortest acting b-blockero Acebutolol possesses all activities i.e., cardioselectivity, partial agonist activity, membrane stabilizing activity and lipid insolubility.o Beta blockers approved for treatment of CHF : Carvedilol most widely used, metaproloL bisoprolol.o Carvedilol is b1 b2- a1 adrenoreceptor blocker with a: b blocking property of 1 : 9. It produces peripheral vasodilatation due to a-l blockade as well as calcium channel blockade direct effect,o Atenolol, sotalol and nodalol are primarily excreted by kidney - should not be given in renal failure,o Sotalol, penbutoloi and pindolol have almost 100 bioavailibility.o Penbutoloi has maximum oral absorption,o Carvedilol has maximum plasma protein binding.o Celiprolol has minimum plasma protein binding. 