<prompt> All are associated with MEN-2 except:PheochromocytomaIslet cell hyperplasiaMedullary carcinoma thyroidParathyroid adenoma  <response>: Type Chromosomal Location Tumors Estimated Penetrance Gene and Most Frequently Mutated Codons MEN 1 11q13 Parathyroid adenoma 90 Enteropancreatic tumor 30-70 Gastrinoma 50 Insulinoma 10-30 Nonfunctioning and PPoma 20-55 Glucagonoma 3 VIPoma 1 Pituitary adenoma 15-50 Prolactinoma 60 Somatotrophinoma 25 Coicotropinoma 5 Nonfunctioning 5 Associated tumors Adrenal coical tumor 20-70 Pheochromocytoma 1 Bronchopulmonary NET 2 Thymic NET 2 Gastric NET 10 Lipomas 33 Angiofibromas 58 Collagenomas 70 Meningiomas 8 MEN 1 8384, 4-bp del ?4 119, 3-bp del ?3 209-211, 4-bp del ?8 418, 3-bp del ?4 514-516, del or ins ?7 Intro 4 ss ?10 MEN 2 10 cen-10q 11.2 MEN 2A MTC 90Pheochromocytoma 50 Parathyroid adenoma 10-25 RET 634, e.g., Cys - Arg 85 MTC only MTC 100 RET 618, missense 50 MEN 2B also known as MEN 3 MTC 90 Pheochromocytoma 50 Associated abnormalities 40-50 Mucosal neuromas Marfanoid habitus Medullated corneal nerve fibers Megacolon RET 918, Met - Thr 95 MEN 4 12p 13 Parathyroid adenoma Pituitary adenoma Reproductive organ tumors e.g., testicular cancer, neuroendocrine cervical carcinoma? Adrenal renal tumors CDKN 1B; no common mutations identified to date 