<prompt> Adenoma sebaceum is seen inSclerodermaTuberous sclerosisSLESystemic sclerosis  <response>: i.e. Tuberous sclerosis: 96Q-CMDT-11 1798 -1000-H17th Adenoma sebaceum subungual fibromas, shagreen patches leathery plaques of subepidermal fibrosis and leaf shaped hypopigmented spots - cutaneous abnormalities seen in TUBEROUS - SCLEROSIS Renal abnormalities includes - Renal cysts, Angiolipomas, Renal cell carcinomaTUBEROUS - SCLEROSIS TS - is an Autosomal dominant inheritance Mutations that inactivating in either the TSCJ gene encoding tuberin or the TSC2 gene encoding hamartin CNS hamartomas can cause seizures, mental retardation and autism Associated abnormalities includes - retinal lesions, benign rhabdomyomas of the heart, lung cysts, benign tumours in the viscera and bone cysts Classical Triad -i Seizuresii Mental retardationiii Adenoma sebacium The characteristic brain lesion is a Cortical Tuber The most common neurological manifestations include seizures, cognitive impairment and behavioral abnormalities including autism 