<prompt> Fluoroqinolone with least oral bioavailability-NorfloxacinOfloxacinCiprofloxacinLevofloxacin  <response>: Ans. is a i.e., Norfloxacin Pharmacokinetic characteristics and doses of fluoroquinolones C1PROFLNORFLPEFLOFLLEVOFLGEM1PRULIMOXI1. Oral bioavailability 60-8035-4590-10085-95-1007090852. Plasma protein binding 20-351520-30252555-7345403. Vo!, of distribution Lkg3-4221.51.3---24. Percent metabolized2025855-105-9070-805. Elimination t 12 hr3-54-68-145-88710-1210-156. Routes of administrationoral, i.v.oraloral, i.v.oral, i.v.oral, i.v.oraloraloral, i.v.7. Dose mg: oral250-750BD400BD400BD200-400BD500OD320OD600OD400OD: i.v.100-200--400200500 --400 