<prompt> Mutation in alpha 5 chain of collagen 4. The diagnosis -Alpos syndromeThin membrane diseaseNodular glomerulosclerosisGood pasture syndrome  <response>: Answer is A Alpos syndrome:Most cases of Alpos syndrome arise from a mutation or deletion of the COL4A5 gene located on the X chromosome which codes for alpha 5 chain of type IV collagen - DavidsonAlpos syndromeAlpos syndrome is an inherited disorder charachterized by hereditary nephritis, senserineural deafness and ocular abnormalities.Alpos syndrome is the most common hereditary nephritisQGenetic defect, PathologyPrimary pathology in Alpos syndrome is an abnormality in type IV collagen Type IV collagen is the predominant collagen in basement membraneThe most common form of Alpos syndrome is due to mutation of the COLA4A5 a 5 Chain gene located on the X chromosomeQ.The most common inheritance pattern for Alpos syndrome is X Linked - Classic Alpos syndrome 