<prompt> Causative agent of Yaws is?Treponema pertenueTreponema carateumTreponema pallidumTreponema endemicum  <response>: ANSWER: A Treponema pertenueREF: Harrisons 17th ed table 163-1FeatureVenereal SyphilisYawsEndemic SyphilisPintaOrganismT. pallidum subsp. pallidumT. pallidum subsp. pertenueT. pallidum subsp. endemicumT. carateumMode of transmissionSexual, transplacentalSkin-to-skinHousehold contacts: mouth-to-mouth or via shared drinking eating utensilsSkin-to-skinUsual age ofacquisitionLateAdulthoodEarly childhoodEarly childhoodchildhoodPrimarylesionCutaneous ulcer chancrePapilloma, often ulcerativeRarely seenNon-ulcerating papule with satellites, pruriticLocationGenital, oral, analExtremitiesOralExtremities, faceSecondarylesionsMucocutaneous lesions; condylomata lata, osteoperiostitisCutaneouspapulosquamouslesions;osteoperiostitisFlorid mucocutaneous lesions mucous patch, split papule, condyloma latumPintides, pigmented, pruriticLatecomplicationsGummas, cardiovascular and CNS involvementDestructive gummas of skin, bone, cartilageDestructive gummas of skin, bone, cartilageNondestructive, dyschromic, achromic macules 