<prompt> An infant presents with irritability, increased tone of extremities and recurrent seizures. Tissue examination reveals globoid cells in parenchyma around blood vessels. What is the most probable diagnosis?Taysachs diseaseKrabbe diseaseAdrenoleukodystrophyKanavans disease  <response>: Refer: Nelsonss textbook of pediatrics, 19th edition, pg no: 2071-2072Krabbe disease KDgloboid cell leukodystrophyAutosomal recessive neurodegenerative disorder.Characterized by severe myelin loss and the presence of globoid bodies in the white matter.Deficiency of lysosomal enzyme galactocerebroside β- galactosidase galactosylceramidase.Accumulation of galactocerebroside causes activation of an alternative catabolic pathway removes a fatty acid from this molecule, generating galactosylphingosine.In patients with KD, galactocerebroside cannot be metabolized during the normal turnover or myelin because of deficiency of galactocerebroside β-galactosidase.Because oligodendroglial cells are responsible for the elaboration of myelin, their loss results in myelin breakdown, thus producing additional galactocerebroside and causing a vicious circle of myelin destruction. 