<prompt> Major source of Von willebrand factor vWF ?ErythrocytesNeutrophilsEndothelial cellsMonocytes  <response>: Ans. is c i.e., Endothelial cells o Circulating factor VIII has two components. a Factor VIIIc Procoagulant protein o This is the smaller component o It is synthesized in liver main source and kidney. It is an intrinsic pathway component required for activation of factor X. b Von willebrand factor vWF o This is the larger component It is produced by endothelial cells main source and megakaryocytes. o It has two major functions. i Helps in platelet adhesion by interacting platelet membrane glycoprotein lb-IX. ii Stabilizes factor VIIIc. 