<prompt> An HIV positive, 36 years old female on A councils. Which of the following 1st trimester markers of Down Syndrome would be affected by?B-hcgPAPP-ANTAll of the above  <response>: Triple test It is a combined biochemical test which includes MSAFP,hCG,UE3 Used in detection of down;s syndrome In an affected pregnancy level of MSAFP AND UE3 tend to be low and hCG is high performed at 15-18weeks D.C.DUTTA;S TEXTBOOK OF OBSTETRICS,Pg no:106,7th edition 