<prompt> All of the following statements are true about theophylline except -Increase in dose is required in cardiopulmonary diseaseIncreases cAMPIncrease in dose is required in smokersInhibits phosphodiesterase  <response>: Ans. is a i.e., Increase in dose is required in Cardiopulmonary disease o Pneumonia and CHF Cardiopulmonary disease require dose reduction not increased dose. o Other options are correct. 