<prompt> After an initial pregnancy resulting in a spontaneous loss in the first trimester, your patient is concerned about the possibility of this recurring. An appropriate answer would be that the chance of recurrenceDepends on the genetic makeup of the prior abousIs no different than it was prior to miscarriageIs increased to approximately 25Is increased most likely to greater than 50  <response>: An initial spontaneous aboion, irrespective of the karyotype of sex of the child, does not change the risk of recurrence in the next pregnancy. The rate of aboion is commonly quoted as 15 of all known pregnancies. Recurrent pregnancy loss is seen in around 1 in 300 pregnancies. For patients with a history of RPL, the risk of subsequent pregnancy loss is estimated to be: 24 after two clinically recognized losses, 30 after three losses 40 to 50 after four losses 