<prompt> Which is the most impoant complication of celiac sprue?Intestinal neoplasmDiabetes mellitusDermatitis herptiformisBile acid diarrhea  <response>: The most impoant complication of celiac sprue is development of cancer both intestinal and non-intestinal neoplasms and lymphomas. Celiac sprue Complications Associated with Intestinal neoplasms lymphoma Refractory sprue Collagenous sprue Dermatitis herpetiformis Type 1 DM IgA deficiency Down ,Turner syndrome 