<prompt> A five year old boy presents with precocious puberty and a blood pressure of 13080 mmHg. Estimation of which of the following will help in diagnosis -17 hydroxy-progesteroneCortisolAldosteroneRenin  <response>: Ans- A. Ref- Nelson Textbook Of Pediatrics Vol. 1 20th ed Biochemical diagnostic studies show elevated levels of serum 17-OHP, the substrate for the defective 21-hydroxylase enzyme activity. 