<prompt> 40F presented to AIIMS OPD with the following findings-Hb-9.8gm, TLC 15,700cumm, Platelet counts 3 laccumm. Peripheral smear showed increased neutrophils with 14 blasts, 15 myelocytes and metamyelocytes with some dysplasia. Cytogenetic study revealed t8;21. What is your diagnosis?AMLCMLMDSALL  <response>: Ans. a AMLRef: Robbins 9thpg 612; 8thpg 622This 40 yr old female is presenting with leukocytosis and increased blast counts in the peripheral smear. The cytogenetic study done here shows t8;21. This finding is suggestive of Acute myeloid leukemia even if there are 20 blast counts.It cytogenetic abnormalities like t15;17,t8;21, inv16 are encountered in a patient with symptomatic myeloid disease, AML should be diagnosed despite the lower blast percent. 