<prompt> A 2 month baby presents with history of jaundice, turmeric colored urine and pale stools since birth. Examination reveals liver span of 10 cms. The most specific investigation for establishing the diagnosis would beLiver function testsUltrasound abdomenPeroperative cholangiogramLiver biopsy  <response>: The given clinical picture is suggestive of either of the following diagnosis:Neonatal hepatiitsExtra hepatic biliary atresiaPercutaneous liver biopsy is the most valuable procedure in the evaluation of neonatal hepatobiliary disease and provides the most reliable discriminatory evidence.Biopsy findings of biliary atresiaBile ductular proliferation Portal or perilobular edema and fibrosis.Bile plug Intact basic hepatic lobular architecture.Biopsy findings of Neonatal hepatitisSevere, diffuse hepatocellular diseaseFocal hepatocellular necrosis.No alteration in bile ductules.Distortion of lobular architecture.Marked infiltration with inflammatory cells.Giant cells are seen in both. 