<prompt> A subtype of Hodgkins which is histogenetically distinct from all othersLymphocyte predominantNodular sclerosisMixed cellularityLymphocyte depleted  <response>: Nodular Lymphocyte-Predominant Hodgkins Lymphoma It is now recognized as an entity distinct from classical Hodgkins lymphoma. Asubset of these patients has tumors with nodular growth pattern and a clinical course that varied from that of patients with classical Hodgkins lymphoma. This is an unusual clinical entity and represents 5 of cases of Hodgkins lymphoma. It has a number of characteristics that suggest its relationship to non-Hodgkins lymphoma. These include a clonal proliferation of B cells and a distinctive immunophenotype; tumor cells express J chain and display CD45 and epithelial membrane antigen EMA and do not express two markers normally found on Reed-Sternberg cells, CD30 and CD15. This lymphoma tends to have a chronic, relapsing course and sometimes transforms to diffuse large B-cell lymphoma.Reference: Harrison;s Principles of Internal Medicine; 19th edition; Chapter 134 Malignancies of Lymphoid Cells 