<prompt> Disulphiram acts by competitive inhibition of which enzyme?Alcohol dehydrogenaseAldehyde dehydrogenaseAlcohol carboxylaseAldyhyde carboxylase  <response>: Ans. b Aldehyde dehydrogenaseRef KDT 6th ed. 386EthanolAlcohol Dehydrogenase---Acetaldehyde Aldehyde Dehydrogenase---Acetate Disulfiram is an anti-craving agent for alcoholics. It has been used as an aversion technique in alcoholics. Disulfiram acts by inhibiting aldehyde dehydrogenase. If a person still takes alcohol while on disulfiram treatment, alcohol is metabolized as usual, but acetaldehyde accumulates. This accumulation of acetaldehyde gives some distressing symptoms like flushing, burning sensation, throbbing headache, perspiration, dizziness, vomiting, confusion and circulatory collapse. Therefore, it is recommended only for those alcoholics who are motivated and sincerely desire to leave the habit. Drugs causing Disulfiram like reaction: Metronidazole Chlorpropamide Cefoperazone Cefotetan Trimethorprim Other drugs that decrease craving for alcohol and smoking: remembered as NATO NALTREXONE ACAMPROSATE TOPIRAMATE ONDANSETRONAlso Know Drug which inhibit alcohol dehydrogenase - FOMEPIZOLE Antidote for methanol poisoning: FOMEPIZOLE ETHANOL Antidote for ethelene glycol poisoning: FOMEPIZOLE 