<prompt> Regarding liver enzymes true is?ALT is less specific than ASTAbsolute levels of enzyme markers correlate with outcomeGlutathione-s-transferase used as hepatic prognostic marker following surgeryNone  <response>: Glutathione-s-transferase used as hepatic prognostic marker following surgery REF: Harrisons Internal Medicine 17th edition chapter 298 The aminotransferases transaminases are sensitive indicators of liver cell injury and are most helpful in recognizing acute hepatocellular diseases such as hepatitis. They include the aspaate aminotransferase AST and the alanine aminotransferase ALT There is a poor correlation between the degree of liver cell damage and the level of the aminotransferases. Thus, the absolute elevation of the aminotransferases is of no prognostic significance in acute hepatocellular disorders. Alanine aminotransferase: Alanine aminotransferase ALT was formerly known as SGPT. This enzyme enters the blood when liver cells are damaged or destroyed and circulates for a few days. ALT is found primarily in the liver. More specific for liver pathology This enzyme is a sensitive indicator of active liver damage but does not indicate the cause or reversibility of the damage. An increase of at least three times normal indicates significant liver damage within the previous 2 to 5 days. Aspaate aminotransferase: Aspaate transaminase AST, also called as serum glutamic oxaloacetic transaminase SGOT. AST is found in the liver, cardiac muscle, skeletal muscle, kidneys, brain, pancreas, lungs, leukocytes, and erythrocytes in decreasing order of concentration. Alpha Glutathione S-Transferase GST Increased GST indicates early hepatocyte injury. Alpha glutathione S-transferase GST is a superior marker of hepatocyte injury from toxicity; ischemia, and other liver injury. It is unique to hepatocytes, found in high concentrations, and is readily released in response to injury. Its rapid release into and removal from the circulation provides immediate information regarding liver status. 