<prompt> A person presents with fever and altered consciousness. Investigations reveal anemia with fragmented red blood cells, platelet count of 20,000mm, serum creatinine of 3.0 mg and normal PT and aPTT. Which of the following is the most appropriate treatment for the patient:Plasma Exchange TherapyCoicosteroids and IntravenousImmunoglobulinsAnticoagulation with Heparin  <response>: Answer is A Plasma Exchange Therapy: Plasma Exchange Therapy is the treatment of choice for TTP Pentad of Fever, Microangiopathic Hemolytic Anemia, Thrombocytopenia platelets count 20,000, Renal Failure Iverum creatinine and Neurological dysfunction altered consciousness together with normal tests of coagulation normal PT and aPTT confirms a diagnosis of Thrombotic Thrombocytopenic Purpura. Plasma Exchange .forms the mainstay of treatment of TTP. Plasma Exchange remains the mainstay of treatment of TTP 