<prompt> Nitroglycerine is used in Angina pectoris. The mechanism of action is primarily aArteriolar dilatorPost capillary venodilatorIncrease oxygen myocardial demandDecrease myocardial work load  <response>: Post capillary venodilator: 540 KDT 7th editionNITRATES GTN, Nitroglycerine Most prominent action is exerted on vascular smooth muscleNitrates dilate veins more than arteriesPeripheral pooling of bloodDecreased venous return ie preload on heart is reducedEnd diastolic size and pressure are reducedDecreased cardiac work Nitroglycerine are used sublingually because terminates first pass metabolism Nitroglycerine is effective when retained sublingually because it is non-ionic and has very high lipid solubility 22-Goodman 