<prompt> Hyderabad following first order kinetics is being administered by constant i.v. infusion at a rate of 10 mgmin. Its steady state plasma concentration is 2mgmin. If the dose rate is increased to 20mgdo, what will be the new steady state plasma concentration6mgdl4mgdl3mgdl1mgdl  <response>: Ref-katzung 10e p44 Dose rateclearancexsteady state plasma concentration Dismiss plasma concentration at steady state is a direct function of the dose rate, clearance is constant. In first order kinetics clearance is constant, plasma concentration at end is directly propoional to the dose rate.thus, doubling of dose rate from 10 to 20mgmin , buildable steady state plasma concentration from 2 to 4mgdl 