<prompt> Which of the following is most strongly associated with pathogenesis of Psoriasis:Th16Th1Th2Th17  <response>: PSORIASIS Lesions are characterized by infiltration of skin with activated T cells, which have a role in the pathophysiology of psoriasis cytokines stimulate keratinocyte hyperproliferation. Earlier it was considered that Th1 cellsCD8 plays most imp. role in pathogenesis, but now Th17 is considered most imp. in pathogenesis, induced by IL-23. Is linked to HLA-Cw6 and, to a lesser extent, to HLA-DR7. Psoriatic ahritis is associated with HLA- B27 