<prompt> Massage and the application of ligaments to painful areas in the body relieves pain due to-Stimulation of endogenous analgesic systemRelease of endorphins by the first order neurons in the brain stemRelease of glutamate and substance P in the spinal cordInhibition by large myelinated afferent fibres  <response>: Ans. D. Inhibition by large myelinated afferent fibresa. Pain:Receptors: naked nerve ending free nerve ending found in almost every tissues of the body. Tract Antolateral- spinothalamic tractTypes of PainNerve fiber involved in transmissionSynaptic transmitters1. Fast mild pain first or fast painSmall diameter myelinated A li fibers; terminate primarily on neurons in laminas I and V of dorsal hornGlutamate2. Slow severe pain slow or second painUnmyelinated C-fiber; terminate primarily on neurons in laminas I and II of dorsal hornSubstance -P 