<prompt> All are true about Gilbes syndrome except ?Mild conjugated hyperbilirubinemiaAutosomal dominantNonnal liver histologyAlmost normal liver function tests  <response>: Ans. is a i.e., Mild conjugated hyperbilirubinemia Gilbe syndrome o Gilbe syndrome is a type of congenital unconjugated hyperbilirubinemia. It is autosomal dominant. o Hepatic biochemical tests are normal There is normal hepatic histology, but in some patients increased lipofuscin pigment may occur. There is mild increase in unconjugated bilirubin -- No kernicterus o Defect is ? a Decreased hepatic uptake of bilirubin b Decreased activity of UDP G transferase o Phenobarbitone decreases the level of unconjugated bilirubin by increasing its conjugation -- Phenobarbitone induces UDPG transferase activity. o Hemolysis may be seen. o The disposition of most xenobiotics metabolized by glucronidation appears to be normal except for antitumor drug irinotecan. 