<prompt> The immunosuppressant action of cyclosporine appears to be due to:Activation of NK cellsBlockade of tissue responses to inflammatory mediatorsInhibition of gene transcription of interleukinsInterference with antigen recognition  <response>: Ref: KDT 6e p838, 839,840 Cyclosporine and tacrolimus acts by inhibiting calcineurin, which is involved in the activation of NFAT. Final result of this process is increased transcription of IL-2 gene. Sirolimus does not inhibit the transcription of IL-2 but interferes with its action. It inhibits the enzyme tyrosine kinase, known as mTOR which is activated byIL-2 