<prompt> Pagets disease of the nipple is treated byRadiotherapyRadical mastectomyBiopsy and simple mastectomyChemotherapy  <response>: Ans. is c i.e., Biopsy and Simple mastectomy Pagets disease of nipple is a chronic eczematous eruption of nipple which may progress to an ulcerated weeping lesion. It is almost always associated with an underlying ductal carcinoma may be in situ Ca or invasive. The underlying lesion may be palpable or not. A complete mammographic workup and biopsy of the nipple and underlying mass if present is done. Pathognomonic histological feature is presence of Pagets cells in the epithelium. A skin specimen containing cells confirms the diagnosis and can be obtained by nipple scrape cytology or biopsy. Pagets disease may be confused with superficial spreading melanoma. Differentiation from pagetoid intraepithelial melanoma is based on the presence of S-100 antigen immunostaining in melanoma and carcinoembryonic antigen immunostaining in Pagets disease. Treatment of Pagets disease includes : - mastectomy axillary staging axillary dissection or sentinel node biopsy wide excision of the nipple and areola to achieve clear margins radiation axillary staging, or lumpectomy radiation therapy axillary lymph node procedure 