<prompt> Vitamin E toxicity causesReduce platelet aggregationPolyneuropathySpinocerebellar ataxiaRetrolental fibroplasia  <response>: A Reduce platelet aggregation Vitamin E Toxicity: It is likely that patients with vitamin E toxicity have been using vitamin E supplements; obtain the dose and duration of vitamin E usage. Assess concurrent use of anticoagulants or aspirin. A nutritional assessment for vitamin K deficiency is useful in patients who present with bleeding or an elevated PT. Effects of acute vitamin E toxicity include the following: Nausea; Gastric distress; Abdominal cramps; Diarrhea; Headache; Fatigue. Easy bruising and bleeding - Prolonged prothrombin time PT and activated partial thromboplastin time aPTT. Inhibition of platelet aggregation: Diplopia - At dosages as low as 300 IU; Muscle weakness; Creatinuria. Chronic toxicity effects include all of the above, suppression of other antioxidants, and increased risk of hemorrhagic stroke. 