<prompt> A traveler drinks a glass of fruit juice with ice cubes made from tap water. E. coli contaminating the water supply grow in the travelers intestine and synthesize a protein that causes his intestinal epithelium to overproduce cyclic AMP, resulting in a watery diarrhea. This syndrome is typical of which of the pathogenic strains of E. coli?EnteroaggregativeEnterohemorrhagicEnteroinvasiveEnterotoxigenic  <response>: Enterotoxigenic E. coli ETEC, an impoant cause of travelers diarrhea, produces a toxin that activates intestinal adenylate or guanylate cyclase. Consequently, the intestinal mucosa overexpresses cAMP, resulting in a mild and self-limited secretory diarrhea. Enteroaggregative E. coli EAEC does not express a toxin, but is seen to cluster over the colonic mucosa in some individuals. Although occasionally found in patients with chronic diarrhea, no clear mechanism for mucosal pathophysiology has been determined for EAEC. Enterohemorrhagic E. coli EHEC, classically associated with strain O157:H7 and present in undercooked hamburgers, expresses a Shiga-like toxin that causes bloody diarrhea and hemolytic-uremic syndrome. Enteroinvasive E. coli EIEC does not express a toxin, but rather is pathogenic through its capacity to invade the colonic mucosa and evoke an inflammatory response. The resulting dysentery-like inflammatory diarrhea generally necessitates vigilant hydration, but no antibiotics are indicated. Ref: Brooks G.F. 2013. Chapter 15. Enteric Gram-Negative Rods Enterobacteriaceae. In G.F. Brooks Ed, Jawetz, Melnick, Adelbergs Medical Microbiology, 26e. 