<prompt> Apoptosis activating factor 1 Apaf-1Activates caspase 9Activates caspase 8Activates Bcl-1 and Mcl-1Binds with mitochondrial cytochrome C  <response>: Apaf-1 combines with cytoplasmic cytochrome C that leads to formation of apoptosome complex which further triggers caspase 9 activation. Thus, leading to apoptosis via intrinsic pathway. 