<prompt> Anti Spasmodic effect is seen with -NeostigminePropanthelineNikethamideAmbenonium  <response>: Ans. is b i.e., Propantheline Antispasmodic drugs i Quaternary compounds - Propantheline, Oxyphenonium, Clidinium, Pipenzolate, Methylbromide, Isopropamide, Glycopyrrolate. ii Teiary amines - Dicyclomine, Valethamate, Pirenzepine. iii Vasoselective antispasmodic drugs acting on urinary bladder - Oxybutynin, Tolterodine, flavoxate. iv Drotaverine Note? All above drugs are anticholinergic except drotaverine. Drotaverine is a non-anticholinergic smooth muscle antispasmodic which acts by inhibiting phosphodiesterase - 4 PDE-4 selective for smooth muscle. Elevation of intracellular cAMPcGMP causes smooth muscle relaxation. It is used in intestinal, biliary and renal causes, uterine spasm, irratable bowel syndrome. 