<prompt> Half-life of insulin is1-2 min4-6 min10-12 min12-16 min  <response>: The half-life of insulin in the circulation in humans is about 5 min. Insulin binds to insulin receptors, and some are internalized. It is destroyed by proteases in the endosomes formed by the endocytotic process.Ref: Ganongs, Review of Medical Physiology, Twenty-Third Edition, Page number: 318 