<prompt> Which of the following acute-phase reactants is responsible for the anemia associated with chronic inflammation?FibrinogenSerum amyloid SAAC-reactive protein CRPHepcidin  <response>: Acute-phase proteins are plasma proteins, mostly synthesized in the liver, whose plasma concentrations may increase several hundred-fold as part of the response to inflammatory stimuli.Three of the best-known of these proteins are:C-reactive protein CRP.Fibrinogen. Serum amyloid A SAA protein. Acute-phase proteins have beneficial effects during acute inflammation, but prolonged production of these proteins especially SAA in states of chronic inflammation can, in some cases, cause secondary amyloidosis.Chronically elevated plasma concentrations of hepcidin reduce the availability of iron and are responsible for the anemia associated with chronic inflammation.Systemic effects of inflammation:Fever: Cytokines TNF, IL-I stimulate production of PGs in hypothalamus.Production of acute-phase proteins: C-reactive protein, others; synthesis stimulated by cytokines IL-6, others acting on liver cells.Leukocytosis: Cytokines CSFs stimulate production of leukocytes from precursors in the bone marrow.In some severe infections, septic shock: Fall in blood pressure, disseminated intravascular coagulation, metabolic abnormalities; induced by high levels of TBF and other cytokines.Reference-Robbins BASIC PATHOLOGY 10th edition pg-87 