<prompt> Red degeneration of fibroid occurs most commonly in:3rd trimester2nd trimester1 st trimesterPostpaum  <response>: Red degeneration of fibroid : Most commonly in Second Trimester . Occurs when the fibroid overgrows its own blood supply. The middle of the fibroid becomes red and soft- a process known as Red degeneration - causing pain and possibly fever. Management of a fibroid with red degeneration in pregnancy is conservative. Never Operate a fibroid in pregnancy since it can cause a lot of bleeding. 