<prompt> 148.Drug of choice for pregnancy-induced hypertension is:AIIMS November 2015, May 2015AtenololNitroprussideEnalaprilAlpha-methyldopa  <response>: Ans. d. Alpha-methyldopa Ref: Williams Obstetrics 24e p100; Dutta 7e p228: Goodman Giffman 12e p773, 774: Katzung 12e p176Drug of choice for hypertension in pregnancy is methyldopa.Methyldopa is a centrally acting antihypertensive agent. It is a prodrug that exerts its antihypertensive action via an active metabolite. Although used frequently as an anti hypertensive agent in the past, methyldopas significant adverse effects limit its current use largely to treatment of hypertension in pregnancy, where it has a record for safety. -- Goodman Gillman 12e p773Methyldopa is a preferred drug for treatment of hypertension during pregnancy based on its effectiveness and safety for both mother and fetus. The usual initial dose of methyldopa is 250 mg twice daily, and there is tittle additional effect with doses 2 gday. -- Goodman Gillman 12e p774Methyldopa was widely used in the past but is now used primarily for hypertension during pregnancy. It lowers blood pressure chiefly by reducing peripheral vascular resistance, with a variable reduction in heart rate and cardiac output. Katzung 12e p176Antihypertensives in PregnancySafeContraindicated LabetaloQ Alpha methyldopaQ Calcium channel blockersQ Hydralazine Sodium nitroprusside ACE inhibitorsQ Reserpine Loratidine Drug of Choice in PregnancyConditionDrug of Choice DOC for malaria in pregnancy ChioroquineQ DOC for anticoagulation in pregnancy HeparinQ Antihypertensive of choice in pregnancy Alpha-methyldopaQ Antihypertensive of choice for hypertensive crisis in pregnancy LabetalolQ DOC for nausea in pregnancy Doxylamine pyridoxineQ Analgesic of choice during pregnancy AcitoaminophenQ Anti-epileptic of choice during pregnancy PhenobarbitoneQ 