<prompt> TRUE about vitamin K isIt is required for synthesis of factor VIIILong term use of antimicrobials can cause deficiency of vitamin KIt is a water soluble vitaminDVT is associated with vitamin K deficiency  <response>: B Long term use of antimicrobials can cause deficiency of vitamin K?VITAMIN K DEFICIENCYoVitamin K is a fat-soluble vitamin that plays an important role in blood clotting-Vitamin K exists in both natural and synthetic forms.oNatural forms of vitamin K include:-Vitamin K1 Phytonadion plant animal sources-Vitamin K2 Menaquinone produced by intestinal bacteria-Vitamin K3 Menndione syntheticoVitamin K functions:-Activation of clotting factors II, VII, IX, X-Required for gama carboxylation of glutamic acid residues of osteocalcin required for bone development-Activation of anticlotting proteins-Protein C SoVitamin K deficiency occurs in:-Inadequate absorption Fat malabsorption syndromes-Chronic diarrhoea-Use of broad spectrum antibiotics due to suppression of vitamin K-synthesizing bacterial flora in the gut-Diffuse liver disease-Coumarin warfarin induces deficiencyoDeficiency manifestations:-Bleeding diathesis-Epistaxis, haematuria, GI bleeding, post op bleeding-skinoUses of vitamin k:-Prevention and treatment of bleeding associated with deficiency states-In obstructive jaundice K1 preferred-Given routines to all neonates to prevent bleeding as intestinal flora necessary for vitamin k synthesis is not developed-As an antidote to oral anticoagulants toxicity-AE: Anaphylaxis, flushing, sweating, dyspnoea, cyanosis, cardiovascular collapseVitamin K deficiency. Source of vitamin KGreen vegetables Synthesized by intestinal flora. Required for synthesisFactors II, VII, IX, X Protein C and S. Causes of deficiencyMalnutrition Biliary obstruction Malabsorption Antibiotic therapy. TreatmentVitamin K Fresh frozen plasmaOther Options?It is required for synthesis of factor VIIIoSince a vitamin K dependent protein, protein C, can inactivate factor VIII, a study was undertaken to determine if the level and stability of factor VIII in plasma are influenced by such a protein.?It is a water soluble vitaminoVitamin B1 thiamine, Vitamin B2 riboflavin, Vitamin B3 niacin, Vitamin B5 pantothenic acid, Vitamin B6, Vitamin B7 biotin, Vitamin B9, Vitamin B12 cobalamin, Vitamin C?Deep vein thrombosis DVT low vitamin D levels are associated with idiopathic deep vein thrombosis.oDeep vein thrombosis DVT is the formation of a blood clot in one or more deep veins. Idiopathic means that it is a condition that occurs unexpectedly or in which the cause is unknown.oDVT may develop if you are sitting for long periods of time or if you have certain medical conditions that affect your bodys ability to form blood clots. 