<prompt> Treatment of lepromatous leprosy isRifampicin DapsoneRifampicin ClofazimineRifampicin Dapsone ClofazimineRifampicin Ofloxacin Minocycline  <response>: Ans. c Rifampicin Dapsone Clofazimine; Ref. Park PSM 22ndpg. 296Recommended regimens of chemotherapy for Leprosy in adultsFORM OF LEPROSYMORE INTENSIVE REGIMENWHO RECOMMENDED REGIMENLepromatousmultibacillaryRifampin 600 mgd for 3 years plus dapsone 100 mgd indefinitelyDapsone 100 mgd self-administered plus clofazimine 300 mg once monthly for 1-2 yrs supervised; and 50 mgd self-adm; and rifampin 600 mg once monthly undersupervision. Note: Clofazimine is unacceptable owing to discoloration of the skin, its replacement by 250-375 mg self-adm daily ethionamide or propionamide has been suggested.Tuberculoid paucibacillaryDapsone 100 mgd for 5 years Dapsone 100 mgd, unsupervised plus rifampin600 mgmonth, supervised for 6 months. Duration of Rx for Multibacillary leprosy MB blisterpacks for 12 months, within 18 months. Duration of Rx for Paucibacillary leprosy PB blisterpacks for 6 months, within 9 months Rifampin is considered the most active agent for the treatment of leprosy. Dapsone inhibits bacterial folic acid synthesis is now considered the second most active drug after rifampin in the treatment of leprosy. Clofazimine is useful in treating dapsone-resistant leprosy and may lessen the severity of ENL. Thalidomide is now approved by the FDA for treatment of ENL. This drug is sedating and extremely teratogenic and should never be taken by anyone who is or may become pregnant. Ethionamide with rifampin 600 mgd is used to treat dapsone-resistant leprosy for who cannot accept the skin- pigmentation of clofazimine. The newer macrolide antibiotics particularly clarithromycin, minocycline a long-acting tetracycline, and a number of fluoroquinolones including ofloxacin, sparfloxacin, and pefloxacin have shown promising bactericidal activity against M. leprae. Ofloxacin and minocycline are being investigated with rifampin in short-course regimens for lepromatous disease. 