<prompt> A 30-years-old lady comes with blood stained discharge from the nipple with family history of breast cancer. Next best step for her will be:DuctoscopySono-mammogramNipple discharge cytologyMRI  <response>: First investigation to be done in suspected case - Mammography In high risk patients eg. Family history positive, BRCA1 positive - MRI Remember: The most common cause of blood-stained discharge from single duct is duct papilloma. The most common cause of blood-stained discharge from multiple ducts is duct carcinoma. The most common cause of serous discharge from the breast is fibrocystic disease of breast. 