<prompt> Alkalinization of urine is required to treat toxicity of all except:SalicylatesBarbituratesAmphetamineMethotrexate  <response>: Changes in urinary pH affect tubular reabsorption of drugs that are paially ionized - Weak bases are ionize more and are less reabsorbed in acidic urine. Weak acids ionize more and are less reabsorbed in alkaline urine. Urine is alkalinized in barbiturate, methotrexate and salicylate poisoning. 