<prompt> Which enzymes activity is increased in low insulinglucagon level?HexokinaseGlucokinaseGlucose-6-phosphatasePyruvate kinase  <response>: Insulin suppresses glucose-6-phosphatase gene.Glucose-6-phosphatase activity is increased in low insulinglucagon level.Glucocoicoids, glucagon, epinephrine are inducers of glucose-6-phosphatase whereas insulin is repressor.Insulin upregulates the transcription of glucokinase, phosphofructokinase, and pyruvate kinase, while glucagon downregulates their transcription.Glucose-6-phosphatase plays an impoant role in the regulation of hepatic glucose production, and insulin suppresses glucose-6-phosphatase gene. 