<prompt> Wof is not a dermatological manifestation of DermatomyositisSalmon rashGottrons patchesMechanics handPeriungual telangiectasia  <response>: Dermatomyositis DM Chronic inflammatory dermatomyopathy presumed to be from immunemediated process with bimodal peak; may only involve skin amyopathic DM or DM sine myositis or only muscle polymyositis; skin findings typically occur 2-3 months before muscle weakness Presents with facial erythema, violaceous poikiloderma of eyelids with edema heliotrope sign, violaceous papules over MP joints Gottrons papules, reddish scaling over knuckles, knees and elbows Gottrons sign, ragged cuticles Samitz sign, nailfold telangiectasias, photodistributed poikiloderma violaceous, - hyperkeratosis and fissuring of hands mechanics hands, - calcinosis seen more in juvenile DM, - fever, malaise; proximal symmetric muscle weakness inability to comb hair, inability to rise from seated position or climb stairs Sclerodermoid changes associated with anti-Ku Antisynthetase syndrome pulmonary disease, ahritis, Raynauds, myositis seen with anti-tRNA synthetase antibodies anti-Jo-1, anti-PL7, anti-PL12 Cardiac involvement poor prognosis with anti-SRP Associations:- Lung and GI cancer most common in men; ovarian and breast cancer in women Histology:- Epidermal atrophy, vacuolar change, mucin deposition, lympho cytic infiltration similar to LE, dermal sclerosis in older lesions; muscle biopsy deltoid frequently or MRI Labs:- ANA 60; muscle enzymes: creatine kinase CK, 90 and aldolase; ESR, transaminases, LDH Treatment:- Oral coicosteroid followed by taper steroid-sparing agent, antimalarial, sun protection. Ref:- Sima Jain; pg num:-139 