<prompt> Regarding termination of drug actionDrugs must be excreted from the body to terminate their actionMetabolism of drugs always abolishes their Pharmalogical activityHepatic metabolism and renal excretion are the two most impoant mechanism involvedDistribution of a drug out of bloodstream terminated drugs effect  <response>: Ref-KDT 6e p23 Action of drug can be terminated by hepatic metabolism or by anal excretion. Most of the dexa inactivated by metabolism. However some Ducks may be activated from inactive form prodrugs and others may produce active metabolite Some drugs main activate from Blood example decoction lives bloodstream and enters the hea to produce its action 