<prompt> Which is true about type II hypersensitivity reaction?Immune complex mediatedAntigen - antibody mediatedArthus phenomenonGranulomatous reaction  <response>: Type II or Cytotoxic Hypersensitivity depends on the abnormal production of IgG or IgM directed against tissue antigens or a normal reaction to foreign antigens expressed on host cells. There are three main mechanisms of injury in Type II reactions: Activation of complement followed by complement mediated lysis or phagocytosis and removal by leukocytes Antibody dependent cellular cytotoxicity Inactivation of a biologically active molecule 