<prompt> Hand, foot mouth syndrome is caused byCisplatinMethotrexate5 FUMetvcergide  <response>: Ans. is c i.e., 5FU Hand foot syndromeo Hand foot syndrome is a form erythromyelalgia manifested as tingling, numbness, pain, erythma, swelling and increased pigmentation of hands and feet,o Two most common drugs causing Hand foot syndrome are:Capecitabine most common5-FU 2nd most commonDrugs causing Hand foot syndromeCommonly associated drugso Capecitabineo Surafenibo Cytarabino 5-FUo Doxorubicin liposomo!Rarely associated drugso Cisplatino Cyclophosphamideo Docetaxelo Daunorubicino Etoposideo Hydroxyureao Methotrexateo Mitotaneo 6-MPo Suramino Paclitaxel 