<prompt> Reis buckler dystrophy affects which layer of the cornea?EpitheliumStromaBowmans layerEndothelium  <response>: CLASSIFICATION OF CORNEAL DYSTROPHIES Dystrophies are classified according to the anatomic site most severely primarily involved, as follows: Anterior dystrophies Stromal dystrophies Posterior dystrophies primarily affects epithelium and Bowmans layer Primarily affects stroma Primarily affects the corneal endothelium and Descemets membrane 1. Epithelial basement membrane dystrophy 2. Reis-Bucklers dystrophy 3. Meesmans dystrophy 4. Recurrent corneal erosion syndrome 5. Stocker-Holt dystrophy 1. Granular Groenouws type I dystrophy 2. Lattice dystrophy 3. Macular Groenouws type II dystrophy 4. Crystalline Schnyders dystrophy 1. Cornea guttata 2. Fuchs epithelial-endothelial dystrophy late hereditary endothelial dystrophy. 3. Posterior polymorphous dystrophy of Schlichting. 4. Congenital hereditary endothelial dystrophyCHED. Reis-Buckler dystrophy Also known as ring-shaped dystrophy due to the typical lesion primarily involving the Bowmans layer is a progressive corneal dystrophy occurring in childhood. It has got an autosomal dominant inheritance. Most patients get frequent attacks of recurrent corneal erosions that usually result in diffuse anterior scarring. Treatment: In early cases, it is same as that of recurrent corneal erosions, i.e. by patching. However, most of the patients ultimately need lamellar or penetrating keratoplasty. Reis-Bucklers corneal dystrophy, is a rare, corneal dystrophy of unknown cause, in which the Bowmans layer of the cornea undergoes disintegration. The disorder is inherited in an autosomal dominant fashion, and is associated with mutations in the gene TGFB1. Ref: Khurana; 4th ed; Pg 117 