<prompt> Which group of anticancer drugs temozolomide belong to:Oral alkylating agentAntitumor AntibioticAntimetaboliteMitotic Spindle Inhibitor  <response>: Temozolomide is used to treat specific types of brain cancer eg, glioblastoma multiforme, anaplastic astrocytoma in patients whose tumors have returned or whose tumors have just been diagnosed. It belongs to the group of medicines known as antineoplastics cancer medicines. Mechanism of Action Imidazotetrazine derivative prodrug; active metabolite MTIC methylates guanine-rich areas of DNA that initiate transcription, which lead to DNA double strand breaks and apoptosis Absorption Rapidly and completely absorbed after oral administration Peak Plasma Time: 1 hr empty stomach; 2.25 hr high-fat meal Bioequivalence: 100; IV infusion when administered over 90 min is bioequivalent to same dose of oral capsule Mean peak plasma concentration and AUC decreased by 32 and 9, respectively when administered after a high-fat breakfast Distribution Protein Bound: 15 Vd: 0.4 Lkg Metabolism Metabolite: Hydrolyzed at physiologic pH to 3-methyl-triazen-1-yl imidazole-4-carboxamide MTIC; MTIC fuher hydrolyzed to to 5-amino-imidazole-4-carboxamide AIC, which is known to be an intermediate in purine and nucleic acid biosynthesis, and to methylhydrazine, which is believed to be the active alkylating species Elimination Half-life: 1.8 hr Clearance: 5.5 Lhrm2 Excretion: primarily urine 38 REFERENCE: 