<prompt> Sustained Response to antiviral therapy IFN Ribavarin in hepatitis C is indicated byHigh HCV-RNACirrhosisAge 40 yearsFemale sex  <response>: Answer is D Female sex: Female sex is a ourable feature, associated with sustained responsiveness to antiviral therapy Male sex is associated with reduced responsiveness. Reduced Responsiveness Genotype 1 High levels of HCV RNA Adranced fibrosis ciorrhosis, bridging fibrosis Long duration disease Age 40 years I mmunosupression African American Obesity Hepatic steatosis Reduced adherence Male sex Handbook of Gastroenterology Sustained Responsiveness Genotype 2 and 3 Low levels of HCV RNA Minimal fibrosis Sho duration disease Age 40 years Immunocompetance Others Absence of obesity Absence of Hepatic steatosis Increased Adherence Female sex Handbook of Gastroenterology 