<prompt> All are features of Intravasular hemolysis except ?ThrombocytopeniaHemosiderinuriaDecreased haptoglobinRaised indirect bilirubin  <response>: Ans. is a i.e., Thrombocytopenia Hemolytic anemia o Hemolytic anemia is anemia due to hemolysis, i.e. the abnormal breakdown of red blood cells. o Hemolytic anemia has the following features ? 1.A shoened red cell life span, i.e. premature destruction of red cells. 2.Elevated erythropoietin level and inceased erythropoiesis in the marrow and other sites, to compensate the loss of red cells -- characterized by increased reticulocyte count. 3. Accumulation of the products of hemoglobin catabolism due to an increased rate of red cell destruction. o Hemolysis may occur either inside the blood vessels intravascular hemolysis or within the mononuclear phagocytic system of spleen, liver or bone marrow extravascular hemolysis. Intravascular hemolysis o Due to destruction of RBC, hemoglobin is released into blood -- Hemoglobinemia. o Excess of hemoglobin may be excreted by kidney -- hemoglobinuria. Some of the hemoglobin is reabsorbed in kidney and is conveed to hemosiderin which is then excreted -- hemosiderinuria. o Free hemoglobin in plasma bound to haptoglobin and this complex is rapidly cleared by mononuclear phagocytic system -- Decreased heptoglobin. o When heptoglobin is depleted, free hemoglobin is oxidized to methemoglobin -- methemoglobinemia. Excess heme groups are catabolized to bilirubin within the mononuclear phagocytic system -- Increased indirect bilirubin and jaundice. LDH is stored in the blood. During hemolysis this enzyme is released in the blood Increased serum LDH. 