<prompt> The genetic mutation most commonly linked with congenital central hypoventilation syndrome is:Mutation in sodium channel alpha 1 subunitMutation in paired like homeobox 2B geneMutation in outer dynein armAll of the above  <response>: b. Mutation in paired like homeobox 2B geneRef: Nelsons 20e p 2148Congenital central hypoventilation syndrome CCHS or Ondine curse is most commonly related to a PHOX2B fpaired-like homeobox 2B mutation, which presents in the neonatal period and also associates with autonomic problems Hirschsprung disease and neural crest tumorsIn the classic case of CCHS, symptoms of alveolar hypoventilation are manifest in the newborn period and during sleep only--with diminished tidal volume and a typically monotonous respiratory rate with cyanosis and hypercarbia. In more severe cases of CCHS, the hypoventilation is manifest during wakefulness and sleep. 