<prompt> Sister Mary Joseph nodule is most commonly seen with:Ovarian cancerStomach cancerColon cancerPancreatic cancer  <response>: Stomach cancer Repeat from May 09 Sister Mary Josephs nodule - is a periumbilical nodule or hard mass. - It is clinically quite valuable. It represents metastatic involvement of the paraumbilical nodes from intrapelvic or intraabdominal malignancies. - This finding was first repoed in an aicle published in 1928 by W. J. Mayo. The aicle was based on an observation of Mayos first surgical assistant, Sister Mary Joseph of St. Marys Hospital. She observed that patients with this finding had a poor prognosis. The .four most common tumors to present with this sign are - stomach 20, - large bowel 14, - ovary 14, and - pancreatic tumors 11. Ref: - Dermatology secrets By James E. Fitzpatrick, John L Aeling p346; GIliver secrets By Peter R. McNally 