<prompt> Which of the following is not a major criteria for diagnosis of multiple myeloma?Lytic bone lesionsPlasmacytoma on tissue biopsyBone marrow plasmacytosis 30M spike 3g for Ig G, 2g for IgA  <response>: Lytic bone lesions is not a major criteria for the diagnosis of multiple myeloma. It is a minor criteria for the diagnosis of multiple myeloma. So Lytic bone lesions is the single best answer of choice. Ref: The Washingtom Manual of Surgical Pathology: Depament of Pathology By Peter A Humphrey, Loius P.Dehner, Ohn D. Pfeifer, Page 565. 