<prompt> Major source of collagen in cirrhosis -Kupfer cellsIto cell Hepatic stellate cellHepatocyteCanalicular cell  <response>: Ans. is b i.e., Ito cell Hepatic stellate cello Perisinusoidal stellate cells Ito cells play a role in the storage and metabolism of vitamin A and are transformed into collegen producing myofibroblasts when there is inflamation of the liver. These cells are the major source of collegen in cirrhosis. 