<prompt> Side effect of Depot MPA are all, EXCEPTWeight gainIrregular bleedingAmenorrheaHepatitis  <response>: Ans. is d i.e Hepatitis DMPA i.e. depot medroxy progesterone acetate depot provera and Net en are progesterone only injectable contraceptives DMPA-. It is administered as an intramuscular injection every 3 monthsdeg 150mg every 3month. Mechanism of action : Same as other progesterone contraceptive i.e. thickening of cervical mucus and endometrial atrophy making it less receptive to implantation and by inhibiting ovulation by blocking LH surge. Suited ideally for : -- Lactating womendeg In sickle cell diseasedeg as it makes sickle cell crisis less frequent and less painful -- In seizure disorder as it raises seizure threshold. Other advantages : -- Has no cardiovascular risk -- No excess risk of breast cancer -- Has all benefits of progesterone component as in OCPs see 0. No. 11. Side effect of DMPA include : Irregular bleeding Poor cycle controldeg Most common side effect Occasional phase of amenorrheadeg Weight gaindeg Prolonged infeility after its usedeg Ovulation begins 6 - 12 months after the last injection Breast tenderness Decreased bone mass after prolonged use so women shold be advised to use calcium supplementation. Depression. Absolute contraindications for the use of DMPA : Pregnancy Unexplained Genital bleeding Severe coagulation disorder Previous sex steroid induced liver adenoma. 