<prompt> An antidepressant drug which is known to have both high sedative and anticholinergic activity is:PhenelzineAmitriptylineFluoxetineTrazodone  <response>: Ref: KDT 6e p443, 444 Tricyclic antidepressants TCA possess anticholinergic and sedative propeies. Amitriptyline and tripitramine possess highest sedative and antimuscarinic actions. 