<prompt> The pathogenesis of hypochromic anemia in lead poisoning is due to -Lead blocks transferrin receptors of erythroid precursorsBinding of lead to transferrin, inhibiting the transpo of ironInhibition of enzymes involved in heme biosynthesisInhibiting breakdown of ferritin into hemosiderin  <response>: Iron should be combined with protoporphyrin to synthesize Heme. To synthesize protoporphyrin and combine it with iron, enzymes like ALA synthase, ALA dehydratase Ferrochelatase are required. Lead inhibits heme synthesis by inhibiting enzymes ALA dehydratase Ferrochelatase resulting in microcytic hypochromic anemia. 