<prompt> A patient was started on fluphenazine. After few weeks of treatment, he started developing tremors, rigidity, bradykinesia and excessive salivation. First line of management for this patient isTrihexyphenidylPramipexoleAmantadineSelegiline  <response>: Fluphenazine - D2 blocker Anti-psychotic This is a case of typical antipsychotic induced parkinsonism. The only group of drugs effective against Pharmacological parkinsonism Drug induced parkinsonism are Anti-cholinergic agents Trihexyphenidyl: Has high Central: Peripheral anticholinergic actions than atropine Acts by reducing unbalanced cholinergic activity in striatum of parkinsonism patients Order of relief of symptoms: Tremors Rigidity Hypokinesia Peripheral actions - responsible for treatment of sialorrhea Started at low dose and gradually increased 