<prompt> Fibrosis is due to-TGF-bTNF-aIL - 7IL -10  <response>: Robbins and Cotran pathologic basis of disease South Asia edition. Robbins 9e p46 activated macrophages secrete 1 growth factors ,TGF Beta:tissue repair and fibrosis. 2 IL 10 ,TGF Beta: anti inflammatory effect. 