<prompt> Mechanism of action colchicine in acute goutUric acid nephrolithiasis.Deficiency of enzyme Xanthine oxidaseIncrease in serum urate concentrationRenal disease involving interstitial tissues  <response>: Gout is a hereditary disorder with increase in serum uric acid due to increased production, or decreased excretion of uric acid and uric salt. Thought to be caused by lack of an enzyme needed to completely metabolise purines for renal excretion. REF : HARRISONS 21ST ED 