<prompt> Intracanalicular hepatic apparatus is affected by-a Alagille syndromeb Cystic fibrosisc Congential hepatic fibrosisd Caroli diseasee Polycystic liver diseasebcdeabdabcdacde  <response>: A heterogenous group of lesions causing altered architechture of intrahepatic billiary tree. They are :Von Meyenburg complexes Congenital hepatic fibrosisPolycystic liver diseaseCaroli diseaseAlagille syndrome is absence of portal tract, bile duct peculiar facies, vertebral anomalies and CVS defects.In cystic fibrosis bile canaliculi are plugged by mucinous material when longstanding, can cause biliary cirrhosis. It cause ductular proliferation and portal inflammation. 