<prompt> NADPH, H is generated in the reaction catalysed byLDHG-6 PDG-3 PDAlcohol dehydrogenase  <response>: Step 1 of HMP Pathway Glucose-6-phosphate is oxidized by NADP dependent Glucose-6-phosphate dehydrogenase GPD. 6-phospho gluconolactone is formed. One molecule of NADPH is formed in the reaction Fig. 10.1. This is the rate-limiting step. Regulation is affected by this enzyme.Ref: MN Chatterjea Textbook of Medical Biochemistry, 8th Edition, Page no: 113 