<prompt> All are true about immunosuppressants except?Tacrolimus inhibits calcineurin pathwaySteroids binds to cytosolic receptors and heat shock proteinsMycophenolate inhibits purine synthesis GMP dehydrogenaseSirolimus will block kinase in the IL-2 receptor pathway  <response>: Ans. is c i.e., Mycophenolate inhibits purine synthesis GMP dehydrogenase o Mycophenolate inhibits purine synthesis inosine monophosphate IMP dehydrogenase not GMP dehydrogenase. About other options o Tacrolimus enters target cells and binds to FKBP. The complex then inhibits calcineurin response of the helper T cell to antigenic stimulation fails. o Glucocoicoids bind cytosolic receptors and heat shock proteins, block transcription of IL-1, 2, 3, 6, IFN-y and TNF-cs o Sirolimus complexes with FkBP -12 and then blocks p7deg S6 kinase in the IL-2 receptors pathway for proliferation. 