<prompt> In alveolar variant of rhabdomyosarcoma , the resultant fusion protein is believed to function asActivated growth factor receptorChimeric transcription factorConstitutively active kinaseNovel growth factor  <response>: In Alveolar rhabdomyosarcoma, there is frequently fusion of the FOXO1 gene to either the PAX3 or the PAX7 gene, rearrangements marked by the presence of 2;13 or1;13 translocations, respectively. PAX3 is a transcription factor that initiates skeletal muscle differentiation, and it appears that the chimeric PAX3-FOXO1 fusion protein interferes with the gene expression program that drives differentiation. 