<prompt> Hereditary spherocytosis is due to deficiency of: September 2007SpectrinPyruvate kinaseCytokeratinIntegrin  <response>: Ans. A: Spectrin Hereditary spherocytosis HS is due to a deficiency of a protein called ankyrin. Ankyrins are cell membrane proteins thought to interconnect integral proteins with the spectrin-based membrane skeleton The ankyrin of red blood cells erythrocytic ankyrin is called ankyrin-Rankyrin-1 ANK1. 