<prompt> The major clinical manifestation of Wilson disease in children 8-16 years of age isHepatic dysfunctionCardiac failureThromboembolic eventBlindness  <response>: Hepatic dysfunction Wilsons disease or hepatolenticular degeneration is an autosomal recessive disease in which copper accumulates in tissues this manifests as neurological or psychiatric symptoms and liver disease. The condition is due to mutation in the Wilson disease protein ATP7B gene Hepatic manifestation occur in 50 of patient mean age of onset of hepatic manifestation is 11.4year. 