<prompt> True regarding Philadelphia chromosome are all of the following except: March2008Present in 95 of CML patientsIt is the result of a reciprocal translocationSpecific for CMLDesignated as t9;22 q34;q11  <response>: Ans. C: Specific for CMLPhiladelphia translocation is a specific chromosomal abnormality that is associated with chronic myelogenous leukemia CML.It is the result of a reciprocal translocation between chromosome 9 and 22, and is specifically designated t9;22q34;q11. The presence of this translocation is a highly sensitive test for CML, since 95 of people with CML have this abnormality the remainders have either a cryptic translocation that is invisible on G-banded chromosome preparations, or a variant translocation involving another chromosome or chromosomes as well as the long arm of chromosomes 9 and 22.However, the presence of the Philadelphia Ph chromosome is not sufficiently specific to diagnose CML, since it is also found in acute lymphoblastic leukemia ALL, 25-30 in adult and 2-10 in pediatric cases and occasionally in acute myelogenous leukemia AML. 