<prompt> Which of the following Interleukin is raised in a fever?IFN-γTNF-αIL-10IL-2  <response>: i.e., TNF-α IL-1 and TNF-α are the two most important pyrogens Physiology basics.PyrogensPyrogens are substances that cause fever.Pyrogens may be exogenous or endogenousa Exogenous Bacterial toxinsb Endogenous IL-1, TNF-a, IL-6, Interferons, Ciliary neurotrophic factorThese pyrogens increase the level of PGE2 in the hypothalamus that elevates the thermoregulatory set point and causes fever. 