<prompt> Which of the following does not cross the cell membrane :Glucose-6-phosphateGlucoseNitrous oxideCarbon monoxide  <response>: A i.e. Glucose-6-phosphate Glucose-6-phosphate cannot cross the cell membrane unless it in conveed into Glucose by the enzyme - Glucose-6-phosphatase.QVon Gerkes disease in deficiency of Glucose-6-phosphatase leads to accumulation of glucose-6-phosphate and hence glycogen in the liver. In the absence of this enzyme, glucose-6-phosphate is not conveed into glucose and thus cannot enter the blood leading to hypoglycemia. 