<prompt> Which among the following condition is positive for double stranded DNA antibody?SLESjogrens syndromeSclerodermaMixed Connective Tissue Disorder  <response>: Serum antinuclear antibodies ANAs are found in nearly all individuals with active SLE. Antibodies to native double-stranded DNA dsDNA are relatively specific for the diagnosis of SLE. Anti-SSA or anti-SSB antibodies are seen in Sjogrens syndrome. Topoisomerase I antibodies also known as Scl-70, Anticentromere antibodies, Fibrillarin antibodies and antibodies to ribonucleoprotein RNP are present in scleroderma. Anti-U1-RNP antibodies, and antibodies against U1-70 kd small nuclear ribonucleoprotein snRNP are characteristic of mixed connective tissue disorder MCTD. 