<prompt> Lesch nyhan syndrome due fo-HGPRT ase deficieny completeHGPRT ase deficiency partialHexosaminidase deficiency completeHexosaminidase deficiency partial  <response>: Ans. is a i.e., HGPRTase deficiency complete Lesch Nyhan disease LND o X-link recessive disorder o Defect in purine metabolism o complete Deficiency of HPRT enzyme o Manifest as hyperuricemia, intellectual disability, dystonic movement disorder like chorea-athetosis, spasticity, dysarthric speech. Partial deficiency in HPRT --- Keltey-Seegmiller syndrome Iduronate sulfate sulfatase def. - Hunter syndrome o Hexosaminidase dediciency seen in Tay-sachs disease o Glucocerebrosidase def - Gaucher disease o -L Iduronidase def. in Hurler syndrome 