<prompt> Which of the following fungus is exclusively seen in Reticuloendothelial cells -CryptococcusCandidaAspergillusHistoplasma  <response>: Ans. is d i.e., Histoplasma Histoplasma capsulatum is a dimorphic fungus. It is noncapsulated Only medically important capsulatedfungus is cryptococcus. Infectious form is microconidia small spores and mode of transmmission is inhalation of dust contaminated with bird or bat dropping. It causes intracellular infection of reticuloendothelial system. Most of the infections are asymptomatic. Histaplama capsulatum causes Histoplasmosis also called as Darlings disease or Caves disease or Cavers disease. Which many manifests as :-i Acute pulmonary histoplasmosis : Pneumonitis, hilar adenopathy with erythema nodosum and erythema multiforme.Caseation necrosis and calcification may mimic tuberculosis.ii Chronic pulmonary histoplasmosis : Fibronodular apical infiltrates.iii Disseminated infection : Fever, emaciation, lymphadenopathy, hepatosplenomegaly, endocarditis, meningitis.iv Presumed ocular histoplasmosis syndrome POHS. 