<prompt> Rickets is characterized byDecrease in Calcium content of boneWidening of growth cailageBeading of ribsAll of the above  <response>: Rickets Osteomalacia Pathophysiology - Failure of calcification mineralization of cailage and osteoid tissue Clinical featuresRadiological featuresGeneralized muscle weakness, lethargy, irritability and listlessness Protruberant abdomen Large head, open fontanelles and craniotabesThickening of knees, ankle wrists due to physeal overgrowth Rachitic rosary Harrisons groove Pectus carinatumSho stature bowing of long bones with genu valgum, coxa vara, kyphoscoliosis Elongation of physis hazy appearance of provisional zone of calcification Widened growth plate Cupping of metaphysis Splaying and flaring of epiphysis Bowing of diaphysis with thinning of coices OsteopeniaLoosers zone Biconcave codfish veebra Thoracolumbar kyphosis Trefoil Champagne glass pelvis Refer: Tachdijianspaediatric Ohopedics, 5th edition, pg no: 1685-1696 