<prompt> A patient on treatment for leukemia, develops chest pain, pulmonary infiltrates and pleural effusion. The likely cause is:DaunorubicinHydroxyureaCytarabineTretinoin  <response>: TRETINOIN: It is an all trans retinoic acid,a form of Vit A acid which acts as a differentiating agent and has recently emerged as a highly effective treatment for APLAcute Promyelocytic Leukemia. Adverse Effects 10 Headache 86 Fever 83 Bone pain 77 Dry mucous membranes 77 Malaise 67 URI 63 Shivering 60 Dyspnea 60 Hemorrhage 60 Elevated liver function tests 50-60 Hyperlipidemia 60 Infections 58 Nausea and vomiting 57 Rash 54 Peripheral edema 52 Leukocytosis 40 Pain 37 Abdominal pain 31 DIC 26 Respiratory insufficiency 26 Mucositis 26 GI disorder 26 Retinoic acid-APL syndrome 25 Ear ache 23 Diarrhea 23 Pleural effusion 20 Dizziness 20 Pruritus 20 Sweating 20 Anxiety 17 Paresthesia 17 Constipation 17 Vision changes 17 Dyspepsia 14 Rales 14 Depression 14 Insomnia 14 Alopecia 14 Skin changes 14 Confusion 11 Abdominal distention 11 Renal insufficiency 11 1-10 selected: Cardiac failure Pseudotumor cerebri Ulcer. REFERENCE: ESSENTIALS OF MEDICAL PHARMACOLOGY , refence.medscape.com K.D.TRIPATHI SEVENTH EDITION PAGE NO:869 