<prompt> Cyclosporin acts by inhibiting the proliferation of:IL1IL2IL6Macrophages  <response>: Mechanism of action of cyclosporine Normally when antigen presenting cell e.g. macrophage present antigen to Helper T cell, there is activation of T cell by sequential intracellular eventsFirst calcium ions, after binding to calmodulin activate a membrane serine threonine phosphatase called calcineurin. Calcineurin activates nuclear factor of activated T cells NFAT by dephosphorylation. Activated NFAT migrates to nucleus and induce transcription of cytokines IL-2 and other cytokinase. IL-2 activates T cells and cause proliferation of T cells. Cyclosporine enters target cells and bind to cyclophilin an immunophilin. This cyclosporine cyclophilin complex inactivates calcineurin IL-2 trascripitan and proliferation of T cells 