<prompt> True about Lesch Nyhan Syndrome:Patient have normal intellectual capacityPyrimidine overproduction is the causeUric acid stones are frequently formedX- Linked dominant  <response>: Ans. c Uric acid stones are frequently formedRef: Harpers Biochemistry, 30th ed. pg. 354-55, 26th ed.pg. 300LESCH-NYHAN SYNDROME It is a X- linked recessive disorder which is characterized by: An overproduction hyperuricemia Frequent episodes of uric acid lithiasis Self-mutilative behavior, Mental retardation. It reflects a defect in hypoxanthine-guanine phospho- ribosyl transferase, an enzyme of purine salvage. The accompanying rise in intracellular PRPP results in purine overproduction. Mutations that decrease or abolish hypoxanthine-guanine phosphoribosyl transferase activity include deletions, frameshift mutations, base substitutions, and aberrant mRNA splicing. 