<prompt> Thiamine deficiency results in decrease energy production, because TPP:Interferes with Alcohol metabolismInterferes with Transketolase activityIs cofactor for pyruvate dehydrogenase and alpha ketoglutarate dehydrogenaseInterferes with Energy production from amino acids  <response>: Link reaction TCA cycle requires 5 coenzymes: Lipoic acid and four B-complex Vitamins B1, B2, B3, B5. Due to this reason, Thiamine vitamin B1 deficiency results in decrease energy production also CNS problems because Brain cells depend on this aerobic reaction as TCA link reaction both are responsible for energy production in cells. 