<prompt> Which among the following may be used as a sedatives-hypnotic?ZolmitriptanZileutonZolpidemZalcitabine  <response>: ZolpidemThe hypnotic zolpidem is not structurally related to benzodiazepines, but it selectively binds to the benzodiazepine receptor subtype BZ1. Zolpidem has no anticonvulsant or muscle-relaxing properties. It shows few withdrawal effects, exhibits minimal rebound insomnia, and little tolerance occurs with prolonged use. Zolpidem is rapidly absorbed from the gastrointestinal GI tract, and it has a rapid onset of action and short elimination half-life about 2 to 3 hours. It provides a hypnotic effect for approximately 5 hours.Zolmitriptan is one of the drugs used to treat migraine headache. Zileuton is a selective and specific inhibitor of 5-lipoxygenase, preventing the formation of both LTB4 and the cysteinyl leukotrienes. These drugs are useful for treatment of asthma in patients who are poorly controlled by conventional therapy.Key Concept: Zolpidem AMBIEN, others is a non-benzodiazepine sedative-hypnotic drug. Reference: Lippincott Illustrated Reviews: Pharmacology Wolters Kluwer Sixth Edition page no 129, 465,385; Goodman and Gillman, the Pharmacological basis of Therapeutics 12 ed page no 467 