<prompt> Which one of the following inhalational anesthetics is most likely to cause fluoride ion nephrotoxicity?Metho-oxyfluraneEnfluraneHalothaneIsoflurane  <response>: Ans. is a i.e., Methoxyflurane o All inhalational agents depress renal function by decreasing the renal blood flow. Direct toxicity is caused by fluorinated compounds due to the production of Inorganic fluoride F .AgentFluoride level producedo Methoxyflurane50-80 mm maximumo Sevoflurane30 - 50 mmo Enflurane20 - 25 mmo Isoflurane4-8 mmo HalothaneProduces only in anaerobic conditionso DesfluraneNil minimalo Renal threshold beyond which fluoride levels are toxic is 50 mm. Methoxyflurane is most nephrotoxic -Causes high output Polyuric renal failure. Desflurane has no nephrotoxicity.o Sevoflurane enflurane does not cause renal toxicity in a normal person but should be avoided in renal diseases. 