<prompt> All of the following are true regarding progressive multifocal leukoencephalopathy exceptOnly manifestation of JC virus infectionLate manifestation of AIDSCerebellar involvements is unknownnone  <response>: . Progressive multi focal leukoencephalopathy characterised by cytological alternations in both astrocytes and oligodendrocytes . Oligodendrocytes are enlarged ,densely staining nuclei that contain viral inclusions formed by crystallinearrays of JC virus paicles Almost all patients will have underlying immunocompromissive disorders ,most common associated condition is AIDS80, hematological malignancy13, transplant recipient5 and chronic inflammatory disease2. Ref Harrison20th edition pg 2456 