<prompt> Localised regional cerebral atrophy is seen in:Alzheimers diseaseFrontotemporal dementiaPMLC.J. disease  <response>: Answer is B Frontotemporal dementia: Fronto-temporal dementia is characterized by localized or regional atrophy of the temporal and or frontal lobe. The distinguishing anatomical hallmark of Frontotemporal dementia is a marked lobar atrophy regional atrophy of temporal andor frontal lobe - Harrison 17th2544 Condition Frontotemporal dementia Alzheimers disease PML C. J. disease Friedreichs Ataxia Anatomical Feature Regional Atrophy of temporal andor frontal lobe Widespread demyelinating lesions of cerebral coex Diffuse cerebral atrophy Widespread neuronal loss and gliosis Cerebral coex is usually not involved. Involvement is primarily restricted to spinal cord, brainstem and cerebellum. 