<prompt> Th 1 type of cells are most dependent on -IFN-yIL-4IL-5IL-6  <response>: Ananthanarayanan and Panikers textbook of microbiology 9th edition . TH1 cells which produce cytokines , INF Gamma and IL2, which activate macrophage and T cells promoting cell mediated immunity, destruction of the target cells and killing of intracellular pathogens. . 