<prompt> Anti-diabetic effect of sulfonylureas is by reducing:Glucagon productionInsulin secretionTissue sensitivity to insulinTissue sensitivity to glycogen  <response>: Ans. A Glucagon productionRef: KDT 8e p294Sulfonylureas act byIncreasing insulin release from pancreas not by decreasing insulin secretion, so option b ruled out.A minor action reducing glucagon and increasing somatostatin release has been demonstrated. 