<prompt> In a patient suffering from chronic myeloid leukemia, Hb falls from llg to 4g in a sho span of time, and splenomegaly occurs. The cause could be -Accelerated phaseCML in blast crisisIneffective erythropoiesisMyelofibrosis  <response>: Accelerated phase of CML is defined as increasing degree of anemia ,blast count in blood or marrow between 10-20 ,marrow basophils 20 or more ,platelet ciunt falling below 1,00,000microlitre.An accelerated phasecof CML is characterised by progressively rising leucocytosis associated with thrombocytosis or thrombocytopenia splenomegaly. Reference :Harsh mohan textbook of pathology sixth edition pg no 358 