<prompt> True about sickle anemia is -LeucopeniaDecreased ESRMicrocardiaRinged sideroblast  <response>: Answer- B. Decreased ESRInvestigations in sickle cell anemia-Peripheral smear shows sickle cells, target cell and Howell - Jolly bodies.ESR is decreasedPositive sickling testHb electrophoresis shows two bands in heterozygous statesickle cell trait.Bone changes on X-ray show:-A. Fish mouth veebraeB. Crew hair cut hair on end appearance of skull.Hair on end appearance is also seen in thalassemia, hereditaty spherocytosis and G6PD deficiency.Gamma Gandy bodies 