<prompt> Prophylaxis of a neonate born to a HBsAg positive mother should include:VaccineImmunoglobulinsBoth Vaccine and ImmunoglobulinNo active treatment required  <response>: Infants born to HBsAg positive mothers should receive both HBIG and HB vaccine IM at separate sites within 12 hours of bih followed by 2nd and 3rd doses of vaccine at 1 and 6 months respectively. Ref: Harrisons Internal Medicine, 17th Edition, Page 1948; Essential Pediatrics By O P Ghai, 6th Edition, Page 216 