<prompt> Not included in the definition of substance abuse syndrome:Withdrawal symptoms and tolerance to drugsUse despite knowing that it can cause physicalmental harmUse despite substance related legal problemsrecurrent substance abuse  <response>: The DSM-IV, diagnosis of substance abuse includes the following four criterion 1 recurrent use resulting in failure to fulfill major obligations at work, school or home. 2 Recurrent use in situations in which it is physically hazardous such as while driving 3 substance use causing legal problems and 4 substance use causing social or interpersonal problems e.g. fights with spouse. Withdrawal and tolerance are a criterion for substance dependence but not substance abuse Please remember in DSM-5, both these diagnosis of substance dependence and substance abuse have been removed and replaced by substance use disorders. 