<prompt> A patient presents with respiratory symptoms i.e. cough, hemoptysis and glomerulonephritis. His c-ANCA level in serum was found to be raised. The most likely diagnosis is:Goodpasteurs syndromeClassic polyaeritis nodosaWegners granulomatosisKawasaki syndrome  <response>: The major hint here is ANCA positivity. ANCA associated vasculitis includes: Vasculitis without asthma or granulomas microscopic polyangiitis Granulomas, no asthma Wegener granulomatosis Eosinophilia, asthma, and granulomas Chrug-Strauss syndrome ANCA Circulating antibodies that react with neutrophil cytoplasmic antigens, so-called antineutrophil cytoplasmic antibodies ANCAs These were previously grouped according to the intracellular distribution of the target antigens cyto-plasmic or perinuclear , but are now classified according to their antigen specificity: Anti-proteinase-3 PR3-ANCA, previously c-ANCA Anti-myeloperoxidase MPO-ANCA, previously p-ANCA. 