<prompt> Alprostadil is not used for treatment of:Erectile dysfunctionPulmonary hypertensionPatent ductus arteriosusCritical limb ischemia  <response>: To maintain patency of ductus arteriosus in neonates with congenital heart defects, till corrective surgery is undertaken, PGE1 Alprostadil is used.Impotence: Alprostadil PGE1 injected into the penis causes erection lasting 1-2 hours. However, oral sildenafil tadalafil is now preferred for erectile dysfunction. Peripheral vascular diseases: PGI2 or PGE1 infused i.v. can relieve rest pain and promote healing of ischaemic ulcers in severe cases of intermittent claudication and in Raynauds disease.Pulmonary hypertension: PGI2 lowers pulmonary artery resistance. Accordingly, few cases of primary pulmonary hypertension have been successfully maintained on epoprostenol infused continuously in a large vein.lndomethacin has been the most common drug used for medical closure of patent ductus arteriosus.Reference: Essentials of Medical Pharmacology Eighth Edition KD TRIPATHI page no 207,219 