<prompt> Treatment of resistant depression is ?ECTSSRITCAsVenalafexine  <response>: Ans. is a i.e., ECT Treatment of depression Drugs : - The treatment of major depression usually requires staing pharmacotherapy with antidepressants. Antidepressants are : - Tricyclic antidepressants TCAs : - Imipramine, Amitriptyline, Trimipramine, Clomipramine, Desipramine, Noriptyline, Amoxapine, Reboxetine. SSRI selective serotonin reuptake inhibitors : - Fluoxetine, Paroxetine, sealine, Citalopram, Escitalopram. These drugs devoid of side effects seen with TCAs and are safe in elderly. Atypical antidepressants : - Trazodone, Mianserine, Mitrazapine, Venlafaxine, Duloxetine, Tianeptine, Amineptine, Bupropion.Not all patient recover completely after treatment; about 25 cases are refractory to treatment. Recurrence rate is 50 after 1st episode and 90 after 3rd episode. ECT Electroconvulsive therapy : - Indications of ECT in depression are : - Suicidal risk AI1MS 01, 00, Al 94, MAHE 01 Depression with psychotic feature Resistant depression Severe agitated or stuporous depression with lack of self care. Psychotherapy : - Suppoive psychotherapy, connitive behavioral psychotherapy. 