<prompt> Potassium sparing diuretics is:FurosemideSpironolactoneMannitolAcetazolamide  <response>: Spironolactone: Ref: 525-KDT 561-KDT 6thCLASSIFICATION OF DIURETICS1. High efficacy diureticsInhibitors of Na - K 2 CY cotransport2. Medium efficacy diureticsInhibitors of Na, Cl symport3. Weak or Adjunctive diureticsa Sulphamoyl derivatives: Furosemide, Bumetanideb Phenoxyacetic acid derivative Ethacrynic acidc Organomercurials: Mersalyla Benzothiadiazines thiazides Chlorothiazide, Hydrochloroth iazide, Benzthiazide, Hydroflumethiazide, Clopamideb Thiazide like related heterocyclicsChlorthalidone, Metolazone, Xipamide, Indapamidea Carbonic anhydrase inhibitors: Acetazolamideb Potassium sparing diureticsI Aldosterone antagonist: spironolactoneII Directly acting: - Triamterene, Amiloridec Osmotic diuretics: Mannitol, Isosorbide, Glycerold Xanthines: TheophyllineSPIRONOLACTONE: - acts on distal tubule exchange of potassium for sodium and CD cellsSide effects 780-81-GGUses Hyperkalemia Dangerous Gynecomastia Impotence, decreased libido Hirsutism, Deepening of the voices, amenorrhoea May induce diarrhea, gastritis, gastric bleeding and peptic ulcer CONTRAINDICATED IN PEPTIC ULCER CNS adverse - Drowsiness, Lethargy, ataxia, confusion and headache Skin rash Breast cancers chronically use and carcinogenic in rodents Primary hyperaldosteronism Edema associated with secondary alderosteronism cardiac failure, hepatic cirrhosis, nephrotic syndrome, severe ascitis Diuretic of choice in hepatic cirrhosis. 