<prompt> Which of the following can be used in Treatment of primary dysmenorrhea-IndomethacinOC pillsMefenamic acidAll of the above  <response>: Ans. is d All of the above Dysmenorrhea is defined as painful menstruation so as to incapacitate day to day activities. Typesa Primary spasmodic: In absence of any pelvic pathologyb Secondary congestive: In presence of pelvic pathology. Primary dysmenorrhea is mostly confined to adolescent, more common among affluent society, generally with a positive family history. The pain always occurs in ovulatory cycles and is usually cured after pregnancy and vaginal delivery. The various theories for primary dysmenorrhea are:i Uterine myometrial hyperactivity, junctional zone JZ: subendometrial layer of myometrium hyperplasia, dysperistalsis and hyperactivity of JZ.ii Overactivity of sympathetic nerves - hypertonicity of circular fibers of isthmus.iii PGFa - is more in ovulatory cycles which causes ischemia of myometrium.iv Vasopressin, endothelins, leukotrienes, and platelet activating factor are all increased which cause uterine hyperactivity, hyperperistalsis, dysrhythmic contractions, ischemia, and pain.v Psychosomatic factors, anxiety lower pain threshold.TreatmentA Assurance, counseling, encourage normal activities.B Drugs NSAIDs: Given for 1 to 3 days, for 3 to 6 cycles. Mefenamic acid 250 to 500 mg tds. Ibuprofen 400 mg tds or naproxen 250 mg qds. Indomethacin 25 mg tds. Newer selective COX-2 inhibitors may also be used. Glycerin trinitrate transdermal patches are also used. OC pills suppresses ovulation and hence used 3 to 6 cycles. TENS transcutaneous electrical nerve stimulation has also been used to relieve the pain.C Surgery very rarely required Laparoscopy maybe very rarely needed to rule pelvic causes especially endometriosis. Laparoscopic Uterine Nerve Ablation LUNA has not been found to be very beneficial Laparoscopic Presacral Neurectomy LPSN to cut down sensory pathways T11-T12 from uterus Cervical dilatation very rarely done. May lead to incompetence in future. 