<prompt> Oligospermia caused by-MethotrexateHydroxychloroq uineLeflunomideD-penicillamine  <response>: Ans. is a i.e., MethotrexateTransient but reversible oligospermia has been repoed in males receiving high dose methotrexate for cancer chemotherapy.Defective oogenesis or spermatogenesis Occurs in methotrexate therapy 