<prompt> Which one of the following diseases or conditions predisposes a patient to acetaminophen toxicity?Type 1 diabetesType 2 diabetesAlcoholismPernicious anemia  <response>: The enzyme that produces the toxic NAPQI, CYP2E1, is induced by alcohol. Diabetes either type 1 or type 2 will not lead to an induction of CYP2E1, nor will pernicious anemia intrinsic factor deficiency or obesity in the absence of alcoholism. Chronic alcoholics have a reduced tolerance for acetaminophen because of the induction of the MEOS, which results in increased levels of CYPE21. 