<prompt> Eight year girl presented by her mother with sexual precocity. She may have the following disorder:HypehyroidismAddisons diseaseMcCune Albright syndromeNeuroblastoma  <response>: McCune-Albright syndrome MAS is classically manifested as a triad of irregular cafe au lait spots, fibrous dysplasia of long bones with cysts, and precocious pubey sexual precocity. This is a sporadic disorder caused by somatic postzygotic activating mutations in the GSalpha subunit that links G protein-coupled receptors to intracellular signaling pathways. Precocious pubey may be central or incomplete. Other clinical manifestations include, Hypehyroidism Adrenal nodules with Cushing syndrome Acromegaly Hyperprolactinemia Hyperparathyroidism Hypophosphatemic hyperphosphaturic rickets Autonomous endogenous-functioning ovarian cysts in girls Must know: Causes of Precocious Pubeal Development: Central GnRH-dependent precocious pubey: Idiopathic Central nervous system abnormalities Acquired--abscess, chemotherapy, radiation, surgical trauma Congenital--arachnoid cyst, hydrocephalus, hypothalamic hamaoma, septo-optic dysplasia, suprasellar cyst Tumors--astrocytoma, craniopharyngioma, glioma Peripheral GnRH-independent precocious pubey: Congenital adrenal hyperplasia Adrenal tumors McCune-Albright syndrome Familial male-limited gonadotropin independent precocious pubey Gonadal tumors Exogenous estrogen--oral contraceptive pills or topical Ovarian cysts females HCG-secreting tumors eg, hepatoblastomas, choriocarcinomas males Ref: Styne D. 2011. Chapter 15. Pubey. In D.G. Gardner, D. Shoback Eds, Greenspans Basic Clinical Endocrinology, 9e. 