<prompt> Peripheral neuropathy as a side effect is caused by which of the following anti cancer drugs ?VincristineCyclophosphamideEtoposideIrinotecan  <response>: Ans. is a i.e., Vincristine Vincristine Oncovin Alkaloid derived from Vinca rosae. Vincristine belongs to the plant alkaloid group of anticancer. Rapidly acting anticancer This class of drugs are also known as spindle poison. These drugs bind to microtubular protein tubulin The drug-tubulin complex then attaches itself to microtubules and causes depolymerization of microtubules. Depolymerization of microtubule causes Mitotic arrest at metaphase Dissolution of mitotic spindle Interference with chromosome segregation Useful for inducing remission in childhood ALL not useful in maintenance therapy It can also be used for pediatric solid tumors Wilms tumor, neuroblastoma, rhabdomyosarcoma and lymphomas. Prominent adverse effects? Peripheral neuropathy Alopecia SIADH Vincristine is a marrow sparing drug but some times it may cause myelosuppression which is very less than vinblastin. Indications of vincristine? Hodgkins disease Wilmss tumour Carcinoma lung Non hodgkin:s. disease Ewings sarcoma Myeloma Vinblastine and vinorelbine are other vinca alkaloids. o Vinblastines most impoant clinical use is the curative therapy of metastatic testicular tumor. o Vinblastine can cause bone marrow suppression in contrast with vincristin, alopecia, and nausea vomiting. o As they arrest mitosis, all vinca alkaloids act in M phase. 