<prompt> Thyroxine binding globulin TBG is increased in:Glucocoicoid therapyNephrotic syndromePregnancyCancer chemotherapy  <response>: TBG concentration increases in conditions of high estrogen levels such as: pregnancy oral contraceptives. TBG concentration is decreased by: Hormones androgens, glucocoicoids; Malnutrition nephrotic syndrome cancer chemotherapy. Drugs, such as phenytoin, salicylates. 