<prompt> Smita is a case of infertility. What is the right time in her menstrual cycle to do endometrial biopsy:12 -14 days17 -19 days20 - 22 days3 - 5 days  <response>: Endometrial biopsy should be taken in premenstrual phase 1 2 days before the onset of menstruationEndometrial Biopsy OPD procedure for hormonal evaluation in case of infertility DUBTB. Usually performed in premenstrual phase from the lateral wall of vagina. Interpretation:Presence of secretory endometrium Progesterone phase cycles has been ovulatoryPresence of proliferative endometrium Estrogen phase cycles has been anovulatory Luteal phase defect can also be diagnosed by endometrial biopsy which shows a lag of 2 3 days between calendar and histological dating of specimen. Note: For the diagnosis of luteal phase defect endometrial biopsy is done between day 24-26 of the menstrual cycle or 2 to 4 days before anticipated menstruation. Endometrial biopsy is contraindicated in suspected malignancysepsis. 1st sign of ovulation on endometrial biopsy is parabasal vacuolation 