<prompt> Insulin acts on glucose metabolism bypermeability of glucose across cell membranepermeability of glucose across cell membrane against glucose gradientpermeability of renal cellsglucose transpo to brain  <response>: Insulin signals the cells of insulin-sensitive peripheral tissues, primarily skeletal muscle, to increase their uptake of glucose.Secondly, insulin acts on the liver to promote glycogenesis.Finally, insulin simultaneously inhibits glucagon secretion from pancreatic a-cells, thus signalling the liver to stop producing glucose glycogenolysis and gluconeogenesis Ref: DM Vasudevan, 7th edition, page no: 165, 318, 323 