<prompt> Permissible ischemia time for a proximal limb amputations:4 hours6 hours8 hours12 hours  <response>: Irreversible necrotic changes begin in muscles after 6 hours of ischemia warm ischemia time, it is preferable to begin the replantation of pas with good muscular bulk viz. pas proximal to palms and foot within this time. With cooling to 4degC, this time may be extended to 12 hours cold ischemia time. Sequence of reimplantation Mnemonic: BE FAN VS B- Bone first to be implanted E- Extensor tendon F- Flexor tendon A- Aeries N- Nerves V- Veins S- Skin preserved first implanted last 