<prompt> Dose of drug require no or minor adjustment in renal failure, except -DoxycyclineVancomycinChloramphenicolClindamycin  <response>: Ans. is b i.e., Vancomycin o Vancomycin causes renal toxicity which is dose related therefore significant dose reduction is needed in renal failure. o Rest of the drugs asked in the question are metabolised mainly in liver therefore no adjustment needed in renal failure. 