<prompt> Periodic Acid Schiff PAS-Positive macrophages deposited in Lamina prior of Gastrointestinal tract with history of abdominal pain, diarrhea occur occasionally. The diagnosis isGiardiasisCrohns diseaseWhipples diseaseAmoebiasis  <response>: C Whipples diseaseoTraditional laboratory diagnosis is based on light microscopy, which shows diastase- resistant, Periodic Acid-Schiff PAS-positive, non-acid-fast granules in macrophages The distinction could be made by acid-fast staining, which is positive for patients infected with M. avium and negative for those with Whipples disease.?Whipples Disease: This rare condition is characterized by infiltration of small intestinal mucosa by foamy macrophages, which stain positive with periodic acid-Schiff PAS reagent.oCaused by infection with the Gram Positive Bacillus Tropheryma whipplei.oThe disease is a multisystem.oLab abnormalities:-Anemia, hypoalbuminemia, low serum carotene iron.-Increased stool fat.oBiopsy: Villi become distended with foamy PAS macrophages.-Rod-shaped free bacilli in the lamina propria.oPCR of tissue or blood.CLINICAL FEATURES OF WHIPPLES DISEASEGastrointestinal 70. Diarrhoea 75. Steatorrhoea. Weight loss 90. Protein losing enteropathy. Ascites. Hepato-splenomegaly 5Musculoskeletal 65 Seronegative large joint arthropathy SacroilitisCardiac 10 Pericarditis, Myocarditis Endocarditis, Coronary arteritisNeurological 10-40 . Apathy, Fits. Dementia. Myoclonus, Meningitis. Cranial nerve lesionsPulmonary 10-20. Chronic cough, Pleurisy. Pulmonary infiltratesHaematological 60. Anaemia, Other 40. Fever. Lymphadenopathy. Pigmentation 