<prompt> Breast Cancer which involves both breasts is:Lobular CarcinomaMucoid carcinomaDuctal carcinomaDuctal carcinoma in situ  <response>: Ans. a Lobular carcinomaRef: Sabiston 19th ed.842, Bailey 26th ed. 809LOBULAR CARCINOMA BREAST SALIENT FEATURES Mostly Multi-centric and bilateral Histological hallmark: Indian file pattern due to the tendency of tumor cells to invade in linear strand. Presenting feature-Breast mass with ill-defined margins Cellular feature- cytoplasmic mucoid globule Neighbourhood calcification-calcification in LCIS typically occurs in adjacent tissues. It is a unique feature and adds to diagnosis.BREAST CA- AT A GLANCEMC cancer in women WorldwideMC cancer in women in urban area India MC arise from TDLU terminal duct lobular unit MC type- invasive ductal MC malignant type- inflammatory breast CA MC Site- upper outer quadrant MC Site of metastasis is bone osteolytic lumbar vertebrafemurthoracic vertebrae. MC Cause of death- metastatic disease i.e malignant pleural effusion 2nd Most common cause of cancer death in women 1st is lung in both sexesEvaluation Diagnosis by triple assessment- Clinical Imaging MammographyUSG Histopathology 1st initial Investigation is FNAC Best gold standard test- HPE after biopsy USG- for young patient MRI- Patient with breast implant condition PET scan- For recurrence Mammography- For older patient Mammography: IOC for micro-calcificationBIRADSBreast imaging reporting and data system0- incomplete assessment1- Negative2- Benign3- Probably benign4- Suspicious5- Highly suggestive of malignancy6- Malignant 