<prompt> Causes of reduced bioavailability of a drug includesHigh first pass metabolismIncreased absorptionIV drug administrationHigh lipid solubility  <response>: When the metabolism of a drug is high during its passage from the site of absorption into the systemic circulation, the rate, and extent of absorption of that drug decreases. absorption- amount of drug reaching the systemic circulation from the site of administration Ref.Essentials of medical pharmacology TD Tripathi 7th edition page no.16,27 