<prompt> The vitamin K dependent protein C and S are characterised by their ability to inactivate factor:8a and 5a7a and 5b3a and 3bAll of the above  <response>: Sequence of Events Involved in the Activation of PlasminogenDuring intravascular clotting, the endothelium of the blood vessel secretes a thrombin-binding protein, the thrombomodulin. It is secreted by the endothelium of all the blood vessels, except the minute vessels of brain.Thrombomodulin combines with thrombin and forms a thrombomodulin-thrombin complex.Thrombomodulin-thrombin complex activates protein C.Activated protein C inactivates factor V and VIII in the presence of a cofactor called protein S.Protein C also inactivates the t-PA inhibitor.Now, the t-PA becomes active.Activated t-PA and lysosomal enzymes activate plasminogen to form plasmin. Plasminogen is also activated by thrombin and u-PA. 