<prompt> A person is HBsAg positive, but anti-HBsAg negative, what should be the next stepRepeat test after 6monthsCheck if HBeAg is positiveCheck HBV DNA loadReassure the patient  <response>: HBsAg indicates a current infection.Anti-HBs is generally interpreted as indicating recovery and immunity from hepatitis B virus infection. Anti-HBs also develops in a person who has been successfully vaccinated against hepatitis B.HBeAg is a hepatitis B viral protein. It is an indicator of active viral replication.HBcAg core antigen is a hepatitis B viral protein. It is an indicator of active viral replication.replicative phase is characterized by the presence in the serum of HBeAg and HBV DNA levels well in excess of 103-104 IUmL chronic HBV infection can occur in the presence or absence of serum hepatitis B e antigen HBeAg, the level of HBV DNA correlates with the level of liver injury and risk of progression. 