<prompt> All are true regarding cryptococcal infection, exceptOccurs in immunodeficient statesCapsular antigen in CSF is a rapid method of detectionAnticapsular antibody is protectiveUrease positive  <response>: The disease is more common in an immunocompromised host. 4 serological types of cryptococcal capsular polysaccharide A, B, C and D have been identified. Demonstration of capsular antigen by precipitation can sometimes be valuable for diagnosis of cryptococcal meningitis when the CSF is negative by smear and culture. As the disease is more common in immunocompromised patients, antibodies are not protective. Ref: Textbook of Microbiology, Ananthanarayan and Paniker; 9th edition 