<prompt> Which of the following has strong association with spondyloarthropathies?HLADR3HLAB27HLADR4WHLAB8  <response>: Ans. b HLA B. Ref Harrrisqn 18th Table 315-1.Significant HLA Class I and Class II Associations with Disease. MarkerSpondyloarthropathies including Ankylosing spondylitis, Reiters syndrome, Acute anterior uveitis, Reactive arthritis Yersinia, Salmonella, Shigella, Chlamydia, Psoriatic spondylitisB27Juvenile arthritis, pauciarticularDR8 DR5Rheumatoid arthritisDR4Sjogrens syndromeDR3Systemic lupus erythematosus-WhiteDR3Systemic lupus erythematosus-JapaneseDR2Gluten-sensitive enteropathy celiac diseaseDQ2Chronic active hepatitisDR3Dermatitis herpetiformisDR3Psoriasis vulgarisCw6Pemphigus vulgarisDR4DQ1Bullous pemphigoid variantDQ7Type 1 diabetes mellitusDQ8 DR4 DR3 DR2Hyperthyroidism GravesB8 DR3Hyperthyroidism JapaneseB35Adrenal insufficiencyDR3Myasthenia gravisB8 DR3Multiple sclerosisDR2Behcets diseaseB51Congenital adrenal hyperplasiaB47NarcolepsyDR2Goodpastures syndrome anti-GBMDR2Abacavir hypersensitivityB57COMMON FEATURES OF SPONDYLOARTHROPATHIES ARE High prevalence of HLA B27 Sacroilitis bilateral, symmetric, spondylitis, familial Enthesitis, asymmetrical oligoarthritis Anterior uveitis Negative for Rheumatoid factor. 