<prompt> If a fibrinolytic drug is used for the treatment of acute myocardial infarction, the adverse effect most likely to occur is:Acute renal failureDevelopment of antiplatelet antibodiesEncephalitis secondary to liver dysfunctionHemorrhagic stroke  <response>: Bleeding is the most common adverse effect of anticoagulants, antiplatelets and fibrinolytic agents. Bleeding can manifest as hemorrhagic stroke in pts. on fibrinolytics therapy such as- Alteplase, Retaplase, Streptokinase. CI of Fibrinolytics :- HO Hemorrhagic Stroke HO NON Hemorrhagic Stroke within 1yr Suspicion of aoic dissection Marked hypeension SBP180mm Hg and DBP110mm Hg Active internal bleed Excluding menses 