<prompt> Phospho-dephosphorylation of phosphofructokinase and fructose 1, 6, biphosphatase by fructose 2, 6,biphosphate regulation is seen inBrainLiverAdrenal cortexRBC  <response>: Fructose 2, 6-biphosphate has unique role in regulation of glycolysis and gluconeogenesis in liver. 