<prompt> Gene encoding which protein is defective in Dubin Johnson syndrome?JAG1MRP2ATP7AATP 7B  <response>: B. MRP2Ref: Nelsons 20e p 1931, 1938In Dubin Johnson syndrome, ABCC2 gene is affected, that codes for MRP2 protein. Absent function of multiple drug-resistant protein 2 MRP2, an adenosine triphosphate-dependent canalicular transporter, is the responsible defect, that leads to defective conjugated bilirubin excretion. 