<prompt> All of the following factors tend to increase the volume of distribution of a drug exceptHigh plasma protein bindingLow ionization at physiological pH valuesHigh lipid solubilityHigh tissue binding  <response>: Ref - katzung10e p34,35 If a drug is highly bound to plazma proteins it is more likely to statin blood. Thus its Vd will be less. Low ionizition ours the distribution of drug because unionized molecules can cross the membrane of blood vessel and tissue. 