<prompt> Basement membrane degeneration is mediated byMetalloproteinascsOxidasesElastasesHydrolases  <response>: Ans. a MetalloproteinascsRef: Robbins 9thpg 105The degradation of collagens and other ECM components is accomplished by a family of zinc dependent matrix metalloproteinases MMPs QMMPsFunctions. Interstitial collagenasesCleave fibrillar collagen MMP-1, -2 and -3. Gelatinases. MMP-2 and 9Degrade amorphous collagen and fibronectin;. Stromelysins. MMP-3, -10, and -11Degrade a variety of ECM constituents,including proteoglycans, laminin, fibronectin, and amorphous collagenPLEASE remember ECM is composed ofInterstitial matrixBasement membrane- composed of collage type IV. 