<prompt> Mechanism of action trimetazidine is ?Fatty acid synthase inhibitorNa channel inhibitorK channel openerInhibiting mitochondrial LC3-KAT  <response>: Ans. isdi.e.,Inhibiting mitochondrial LC3-KATRef: KDThe p. 554Trimetazidine:This antianginal drug acts by non hemodynamic mechanisms.The mechanism of action of trimetazidine is unceain, but it may improve cellular tolerance to ischaemia by inhibiting mitochondrial long chain 3-ketoacyl-CoAthiolase LC3-KAT a key enzyme in fatty acid oxidation- thereby reducing fatty acid metabolism and increasing glucose metabolism in myocardium. 