<prompt> Classical markers for Hodgkin;s disease-CD 15 and CD 30CD 15 and CD 22CD 15 and CD 20CD 20 and CD 30  <response>: Immunophenotyping of RS cells reveals monoclonal lymphoid cell origin of RS cell from B cells of the germinal centre in most subtypes of Hodgkin;s disease. RS cells in all types of HD, except lymphocyte predominance type express immunoreactivity for CD15 and CD30.Therefore they ard considered as the classical markers for HD. REFERENCE; Harsh Mohan textbook of pathology,7th edition.Pg no.349 