<prompt> Esketamine, the drug that has been approved by FDA in 2019, has been approved for treatment of -DepressionResistant schizophreniaBipolar disorderKetamine dependence  <response>: In 2019,FDA approved nasal spray of Esketamine It is an enantiomer of ketamine Given as a nasal spray under the practitioners supervision. used for TRDtreatment resistant depression Given with oral antidepressants. 