<prompt> Therapeutic Drug Monitoring TDM involves measurement of plasma concentrations of drugs to find whether the drug levels are within the therapeutic range or not. For TDM to be clinically useful, the following criteria should be fulfilled:There should be good relationship between plasma concentration and drug dosageThe relationship between plasma drug concentration and therapeutic response andor toxicity should be poorWhen pharmacodynamic tolerance is suspectedWhen the clinical response cannot be easily monitored  <response>: Therapeutic Drug Monitoring TDMTDM is a process by which the dose of a drug is adjusted according to its plasma concentration.For performing TDM, there should be good relation between drug concentration and response. Note that there may not be good relation between dose and plasma concentration.It is done for drugs having wide variation in pharmacokinetics absorption, metabolism or excretion, both intra as well as inter- individual.It is done for the drugs having low therapeutic index like theophylline, lithium, antiepileptics, immuno-modulators and antiarrhythmics etc.TDM is done for those drugs whose effect cannot be easily measured like effect of antihypertensive drugs can be easily measured by monitoring BP, so TDM is not used.TDM is not done for the drugs which are activated in the body or produce active metabolites, when pharmacological tolerance is suspected and when there is poor relation between drug concentration and effect. 