<prompt> Prophylaxis for chicken-pox by varicella-zoster immmunoglobulin, true is ?Should be given within 24 hoursGiven to newborn contactCan be given with varicella vaccineCan be given in established disease  <response>: Ans. is b i.e., Given to newborn contact Varicella-Zoster immunoglobulin VZIG given within 72 hours of exposure has been recommended for prevention of chickenpox in exposed susceptible individuals paicularly in immunosupprressed persons. These include :? a Susceptible persons receiving imunosuppressive therapy b Persons with congenital cellular immunodeficiency c Persons with acquired immunodeficiency including HIVAIDS d Susceptible and exposed, persons, in paicular pregnant women e Newborn f Premature infants of low bih weight. It has no therapeutic value in established disease. VZIG is given by intramuscular injection in a dose of 12.5 unitskg body weight up to a maximum of 625 units, with a repeat dose in 3 weeks, if a high-risk patient remains exposed. Because VZIG appears to bind the varicella vaccine, the two should not be given concomitantly. 