<prompt> Spironolactone should NOT be given with the following pharmacological agent:Chlorothiazideb-blockerACE inhibitorsAmlodipine  <response>: Unlike most other diuretics, K-sparing diuretics reduce urinary excretion of K and can cause mild, moderate, or even life-threatening hyperkalemia. The risk of this complication is greatly increased by renal disease in which maximal K excretion may be reduced or by the use of other drugs that reduce or inhibit renin beta blockers, NSAIDs, aliskiren or angiotensin II activity angiotensin- conveing enzyme inhibitors, angiotensin receptor inhibitors. Since most other diuretic agents lead to K losses, hyperkalemia is more common when K-sparing diuretics are used as the sole diuretic agent, especially in patients with renal insufficiency. REF : katzung pharmacology : 14th ed 