<prompt> Which one of the following statements about biguanides is not true -Dont stimulate insulin releaseDont stimulate insulin releaseRenal Dysfunction is not a contraindication for their useRenal Dysfunction is not a contraindication for their use  <response>: Ans. is c i.e., Renal dysfunction is not a contraindication for their use o Biguanides are contraindicated in hypotensive states, cardiovascular, respiratory, hepatic and renal disease and in alcoholics because of increased risk of lactic acidosis. About other options o Biguanides do not cause insulin release. o Their major action is to suppress hepatic gluconcogenesis Decreased hepatic glucose production. o Biguanides may be combined with sulfonylureas and thiazolidinediones in type 2 DM in whom oral monotherapy is ineffective. 