<prompt> A 32-years old male with suspected neurofibroma, tosis was found to have a blood pressure of 178110 mm Hg at a recent health fair. He complained of palpitations and excessive sweating. Today he presents to the clinic for a checkup because he has developed abdominal discomfo. His blood pressure is now recorded to be 13080 mm Hg. Physical examination reveals multiple tumors of the oral mucosa and skin. Laboratory investigations reveal: Serum K : 3.8 mEqL N : 3.5-5.0 mEqL Serum Ca2: 136 mEqL N : 135-145 mEqI, Serum Ca2 : 9.4 mgdL N : 8.4-10.2 mgdL d 14 Genetic studies in this patient will most likely show -N-myc amplificationOverexpression of C-kitK-ras mutationRET oncogene  <response>: The RET proto-oncogene encodes a receptor tyrosine kinase for members of the glial cell line-derived neurotrophic factor GDNF family of extracellular signalling molecules.RET loss of function mutations are associated with the development of Hirschsprungs disease, while gain of function mutations are associated with the development of various types of human cancer, including medullary thyroid carcinoma, multiple endocrine neoplasias type 2A and 2B, pheochromocytoma and parathyroid hyperplasia Ref Davidson 23rd edition pg 1057 