<prompt> Ivabradine is used for management of -Stable anginaPre renal azotemiaAlzheimers diseaseAnti smoking agent  <response>: Ans. is a i.e., Stable angina Ivabradine It is an investigational inhibitor of sino-atrial node. It is a relatively selective If funny current Sodium channel blocker of early part of slow diastolic depolarization phase 4 that reduces heart rate by inhibiting the hyperpolarization-activated sodium channel in SA node. Heart rate is a major determinant of angina in coronary disease. Therefore, lowering the heart rate is an important therapeutic approach in the treatment of stable angina. It lowers heart rate with an efficacy similar to calcium channel blockers and beta blockers but does not have any effect on gastrointestinal and bronchial smooth muscles. It is well absorbed orally, 40 bioavailability due to first pass metabolism. It is excreted in urine with t Vi of 2 hours. 