<prompt> Anticancer drug also used in RA, produces acrolein in urine that leads to hemorrhagic cystitisCyclophosphamideBusulfanProcarbazineMesna  <response>: Cyclophosphamide IMPOANT POINTS ON HEMORRHAGIC CYSTITIS: Drugs causing: Cyclophosphamide Ifosfamide Metabolite responsible: Acrolein - In Cyclophosphamide Chloracetaldehyde - In Ifosfamide Treatment: Mesna. Nitrogen mustards: 1. Cyclophosphamide: Powerful vesicant Prodrug - Activated by hepatic biotransformation to aldophosphamide. Acrolein - One of its degradation products. Responsible for hemorrhagic cystitis - Characteristic adverse effect. Use: DOC for Wegeners granulomatosis. Adverse effects: Hemorrhagic cystitis Characteristic - Treated by mercapto ethane sulfonic acid mesna. May cause cardiac dysfunction, pulmonary toxicity syndrome of inappropriate ADH secretion. 2. Ifosfamide: Produces chloracetaldehyde acrolein as metabolites. Adverse effects: HIGHER risk of neurotoxicity hemorrhagic cystitis. Chloracetaldehyde - Responsible for nephrotoxic. 