<prompt> A 6O year old male complains of tremors in his hands for the past 6 months. He does not smoke cigarettes but drinks 6 beers daily. Physical examination reveals normal vital signs, diminished facial expression, a stooped posture, shuffling gait with sho rapid steps and a pill rolling tremor in both hands. Morphological changes in his brain will IncludePallor and atrophy of the substantia nigraMarked atrophy of the caudate and putamenFrontotemporal atrophy of the cerebral coex with enlarged ventriclesButterfly shaped hemorrhagic mass extending acroos the corpus callosum  <response>: The patient mentioned above has Parkinsons disease. The pathological hallmarks are depletion of the pigmented dopaminergic neurons in the substantia nigra and the presence of alpha synuclein and other protein inclusions in the nigral cells. Reference : Harrison20th edition pg 2456 