<prompt> The enzyme deficient in Lesch Nyhan syndrome is:Adenosine DeaminasePRPP synthetaseHGPRTaseXanthine oxidase  <response>: Ref. Guyton. 13th edition. Page. 879Lesch-Nyhan syndrome results from a defect in HGPRT, an enzyme involved in the purine salvage pathway.HGPRT catalyzes the conversion of the free base hypoxanthine of guanine to a nucleotide IMP or GMP.HGPRT is not required for de novo purine synthesis, or urate synthesis, or for either the de novo or salvage pathways of pyrimidine metabolism.  FeaturesSpastic cerebral palsy Self-mutilation hands, lips Hyperuricemia and goutEarly death X-linked recessive 