<prompt> Physostigmine was therapeuticallyused for the first time in treatment of glaucoma in 1877 byLaqueurPosselt and ReimanAhlquistSir James Black  <response>: LaqueurPosselt and Reiman isolated nicotine from the leaves of Nicotiana tabacum.Ahlquist gave the hypothesis that adrenaline acts on different sets of receptors, later named as α and β.Sir James Black synthesized the first β-blocker, dichloroisoproterenol, and subsequently, propranolol. 