<prompt> 2nd generation sulfonylurea drugs are all exceptGlipizideGliclazideTolbutamideGlibenclamide  <response>: Tolbutamide and chlorpropamide, acetohexamide are first generation sulphonylureas- cause severe hypoglycemiA 2nd gen- less hypoglycemia- gliclazide, glipizide, glibenclamide etc REF.Essential of medical pharmacology K D TRIPATHI 6 Edition, Page No - 266 