<prompt> Loading drug of dose primaraly depends onVolume of distributionClearanceRate of administrationHalf life  <response>: Loading dose; This is a single or few quickly repeated doses given in the beginning to attain target concentration rapidly. Loading dose Target Cp V F Cp-concentration, V - the volume of distribution, F-oral bioavailabilityThus, the loading dose is governed only by V and not by Clearance or t12 Ref ; KD Tripathi Pharmacology 7th edition page no;33 