<prompt> Which of the following drug is associated with highest cardiac moality?RofecoxibNicorandilLosaanMetoprolol  <response>: Rofecoxib is a selective COX-2 inhibitor that was withdrawn due to increased risk of MI. ARBs losaan and b blockers metoprolol are cardioprotective in CHF. These decrease the moality. Nicorandil is a K channel opener used in angina. It is cardioprotective by causing ischemic pre-conditioning. 