<prompt> Most common joint involved in gout is -KneeHipMP joint of great toeMP joint of thumb  <response>: Ans. is c i.e., MP joint of great toe Ref: Harrison 17thep. 2165, 2166o Gout is the common end point of a group of disorders that produce hyperuricemia.o It is marked by transient attacks of acute arthritis intitiated by crystallization of monosodium urate into the joints, leading eventually to chronic gouty arthritis and deposition of masses of urates in joints and other sites, creating tophi.o Most common joint involved in gout is big toe, i.e. metatarsophalangeal joint of great toe.o Tophi are pathognomic of gout. They are formed by large aggregations of urate crystals. The urate crystals are surrounded by -a Macrophagesb Lymphocytesc Large foreign body giant cellso They are seen in the-a Articular cartilages of jointsb Periarticular ligamentsc Tendons and soft tissuesdAchilles tendone Ear lobesf Synovial fluido Less common sites of involvement are -a Kidneyb Nasal cartilagec Skin of the finger tips, palms or soles. 