<prompt> Mechanism of action of Fluoroquinolones isInhibit cell wall synthesisInhibit protein synthesisInhibit DNA gyraseInterfere with DNA synthesis  <response>: Inhibit DNA gyrase 628, 647-KDT 688-KDT 6thFluoroquinolones FQs First generation FQs - Norfloxacin, Ciprofloxacin, Ofloxacin, Pefloxacin Second generation FQs - Lomefloxacin, Sparfloxacin, Levofloxacin, Gatifloxacin, Moxifloxacin. FQs inhibits the enzyme bacterial DNA gyrase, which nicks double stranded DNA, introduces negative super coils and then reseals the nicked ends. FQ action is similar enzyme topo isomerase IV, which nicks and separates daughter DNA strands after DNAreplication. 