<prompt> Which of the following is not true about MebendazoleSafe in pregnancyBroad spectrum antihelminthicRelatively low systemic bioavailabilityActive against both larva and adult worm  <response>: Ans. is a i.e., Safe in pregnancy Mebendazole - It has broad spectrum antihelminthic activity. It is effective against both egg and adults in the following helminths.Round worm AscarisHookworm AncylostomaThread worm EnterobiusWhip worm TrichurisAction on other parasites - Strongyloides - less effective against it.Tapeworm -75 cure rate has been achieved H. Nana - relatively insensitiveTrichinella spiralis - expels the worm out of intestine but not effective against larva.Absorption of mebendazole from intestine is minimal 75-90 of the dose is passed in faecesSafety of mebendazole during pregnancy is not known, but is contraindicated on the basis of animal data.Also knowSite of action of Mebendazole is microtubular protein b tubulin. 