<prompt> A patient presents with nephrotic syndrome and hypoalbuminemia. Protein binding of which drug is not affected:TolbutamideMorphineDiazepamValproate  <response>: Ans. is b Morphine Nephrotic syndrome leads to loss of proteins so the drugs which are highly bound to protein will be affectednow, have a look at the protein binding of the drugs given in the optionsTolbutamide - 90 page 277, K.D.T, 4eMorphine -30p435, K.D.T., 4eDiazepam -99 p-435, K.D. T, 4eValproate -90 p 388, K.D. T, 4eSo the drug which is least bound to protein i.e. morphine will be least affected. 