<prompt> Which of the following is the location of human leukocyte antigen HLA?Sho arm of chromosomes 3Sho arm of chromosomes 6Long arm of chromosomes 3Long arm of chromosomes 6  <response>: The human MHC human leukocyte antigen; HLA consists of a linked set of genes encoding major glycoproteins involved in antigen presentation. The complex locates to the sho arm of chromosome 6 and divides into three separate regions: class I, class II, and class III genes. The class I classic region encodes HLA-A, HLA-B, and HLA-C loci; the nonclassic or class I-related region encodes HLA-E, HLA-F, and HLA-G loci and other immunity-related genes such as CD1. The class II region HLA-D encodes HLA-DP, HLA-DQ, and HLA-DR loci and other genes related to antigen processing, transpo, and presentation, such as, transpoer associated with antigen processing TAP. The class III region encodes genes for tumor necrosis factors and TNF- and TNF-; complement factors C2, C4, and B; and the steroidogenic enzyme 21-hydroxylase. Ref: Jaume J.C. 2011. Chapter 2. Endocrine Autoimmunity. In D.G. Gardner, D. Shoback Eds, Greenspans Basic Clinical Endocrinology, 9e. 