<prompt> Activated protein C inhibit clotting mechanism by inactivating which of the following clotting factors:Factor IIIa and Factor VIIIaFactor VIIIa and Factor IXaFactor Va and Factor VIIIaFactor Va and Factor VIIa  <response>: Protein-C is a vitamin K-dependent protease that requires a cofactor Protein S. Activated Protein Cprotein S forms a complex which is a potent inhibitor of coagulation factors Va and Factor VIIIa. Protein C acts as a Tissue factor pathway inhibitor TFPI 