<prompt> Arrange the steps in oncogenesis in the sequence: 1. increased activity of telomerase2. angiogenesis3. Evasion of host defense 4. Activation of proto-oncogene 5. Warburg effect3-5-4-2-14-5-1-2-31-2-3-4-54-5-3-2-1  <response>: All cancers display eight fundamental changes in cell physiology, which are considered the hallmarks of cancer: Self-sufficiency in growth signals Insensitivity to growth-inhibitory signals Altered cellular metabolism Evasion of apoptosis Limitless replicative potential immoality Sustained angiogenesis Invasion and metastasis Evasion of immune surveillance 