<prompt> A 12 year old boy presents with hemetemesis, malena and mild splenomegaly. There is no obvious jaundice or ascitis. The most likely diagnosis is -EHPVONCPFCirrhosisMalaria with DIC  <response>: Ans is a i.e., EHPVO Information in question are: i Patient is 12 years male ii Hematemesis, melena and mild splenomegaly -- signs of poal hypeension iii No Jaundice or Ascitis So, the boy in question has poal hypeension. o Three most common causes of poal hypeension are: i Extrahepatic poal vein obstruction EHPVO ii Non-cirrhotic poal fibrosis NCPF iii Cirrhosis. In cirrhosis, jaundice ascitis are prominent. So, this option is ruled out. o Now we are left with EHPVO and NCPF. Both these causes non-cirrhotic poal hypeension, i.e. poal hypeension without signs of liver dysfunction. o Both these have similar clinical picture except for the age of presentation. EHPVO is usually seen in young male children 1st and 2nd decade while NCPF is a disease of adults 25-35 years. So, best answer here is EHPVO. 