<prompt> Which of the following drug causes malignant hyperthermia:MivacuriumPancroniumSuccinylcholineAtracurium  <response>: Ans: c SuccinylcholineRef: Millers Anaesthesia Th ed. 866 Malignant hyperthermia is a condition that is usually triggered by exposure to certain drugs used for general anesthesia, specifically the volatile anesthetic agents and the neuromuscular blocking agent succinylcholine. Succinylcholine is depolarizing non competitive M.R. with shortest duration of action 3-5 min due to rapid hydrolysis by pseudo cholinesterase. It causes dualbiphasic block. It causes hyperkalemia, increased intraocular intragastric pressure and temperature which leads to malignant Hyperthermia. Susceptibility to MH is often inherited as an autosomal dominant disorder, for which there are at least 6 genetic loci of interest, most prominently the Ryanodine receptor gene RYR1. DOC for malignant hyperthermia: Dantrolene 