<prompt> Following is a specific antidote for poisoning due to metoprolol:AtropineIsoproterenolGlucagonVerapamil  <response>: Ans. C. GlucagonRef: Goodman Gilmans The Pharmacological basis of Therapeutics 12thed, p317ExplanationB blocker overdosageTreatment Common manifestations Bradycardia MC Hypotension Prolonged AV conduction times, and widened QRS complexes Other manifestations Seizures and depression Hypoglycemia and bronchospasm. Significant bradycardia: initially atropine option a - cardiac pacemaker often required Hypotension: Large doses of isoproterenol option b or an a agonist Glucagon option c: Acts through its own GPCR and independently of the b-adrenergic receptor, has positive chronotropic and inotropic effects on the heart and is used as antidote in p-blocker overdosage.If question was like this: Following are used for poisoning due to metoprolol except:a Atropineb Isoproterenolc Glucagond Verapamil Ans. d. Verapamil Adverse effects depend on various properties of drug like receptor selectivity, membrane stabilizing property, etc. as follows:Adverse effects depend on the following properties of the drugCaution to be exercisedNon-selective b blocker Worsening of asthma, COPD: b1 selective blockers preferred but should be used with caution Worsening peripheral vascular disease: pi blockers well tolerated in mild to moderate PVD, used with caution in severe diseaseb blocker with intrinsic sympathomimetic activity Preferred in patients prone to develop severe bradycardia with b blocker therapy Are less useful in angina patients because of stimulation of heartb blocker with membrane- stabilizing properties Avoid in glaucoma due to risk of Cornell anesthesiab blocker with low lipid solubility Have less CNS adverse effects compared to more lipid soluble Cl in renal failure, because are excreted primarily by kidney 