<prompt> Most sensitive antibody for SLE:Anti-nuclearAnti-ds DNAAnti-SmithAnti-histone  <response>: Autoantibodies in Systemic Lupus Erythematosus SLE Antibody Clinical Utility Antinuclear antibodies Best screening testMost sensitive Anti-ds DNA Specific, correlate with disease activity, nephritis, vasculitis Anti-Sm Most Specific for SLE, marker for CNS lupus Anti-RNP Not specific for SLE Anti-RoLa SS-A Sicca syndrome, neonatal lupus with congenital hea block Anti-histone Drug-induced lupus 