<prompt> What is mechanism of action of colchicine in acute gout?Inhibition of leukotriene B4Inhibition of release of chemotactic factorsBinding to tubulin and inhibition of leucocyte migrationPromotes metabolism of urate crystal  <response>: Ans. c. Binding to tubulin and inhibition of leucocyte migrationRef: Goodman Gilman 12th eP 995Colchicine inhibits tubulins required for mobilization of leucocytes neutrophils in to joints in an acute attack of gout.It also inhibits release of chemotactic factors form neutrophils and inhibits adhesion of neutrophils to endothelium of blood vessels. 