<prompt> In sickle cell anemia defect is in which chain?a-chainb-chainBoth the chainsNone of these  <response>: Ans. b b-chainRef: 9thpg 635-636; 8thpg 645-647In sickle cell anemia defect is: point mutation in the6th codon of b-globin Q that leadsto there placement of a glutamate residue with a valine residue. QLeading to: Abnormal physiochemical propertiesSolubility defect Q of the resulting sickle hemoglobin HbSPromotes the polymerization of deoxygenated haemoglobinLeading to red cell distortionHemolytic anemia, microvascular obstruction, and ischemic tissue damage. 