<prompt> Resistance to acyclovir is most commonly due to mutation in the viral gene that encodes a protein thatConves viral RNA into DNAPhosphorylates acyclovirTranspos acyclovir into the cellTranspos acyclovir out of the cell  <response>: Ref-KDT 6e p768 Nucleosidetide analogues act by conveing to NTPs. First phosphorylation step occurs inside the virus and resistance occurs if there is mutation in this gene 