<prompt> Which is the most common causative agent of gas gangrene?Cl. histolyticumCl. novyiCl. septicumCl. perfringens  <response>: Clostridium perfringens is the most common causative agent of gas gangrene. Gas gangrene: Established agents: C. perfringens Most Common, 60-80 and C. novyi and C. septicum 20-40. Probable agents: C. histolyticum, C. sporogenes, C. fallax, C. bifermentans, C. sordellii, C. aerofoetidum and C. teium. 