<prompt> Mechanism of action of statins:Inhibit HMG CoA synthaseStimulate HMG CoA reductaseInhibit HMG CoA reductaseStimulate HMG CoA synthase  <response>: Ref: KDT 6th ed. pg. 614 HMG-CoA Reductase Inhibitors statins: This class of compound is the most efficacious and best tolerated hypolipidaemic drugs. MOA: Competitively inhibit conversion of HMG-CoA to mevalonate by the enzyme HMG-CoA reductase. Drugs Statins: Lovastatin, Simvastatin, Pravstatin, Atorvastatin, Rosuvastatin All statins are given at night except: Rosuvastatin, Atorvastain can be given at anytime Major side effects of statins: Myopathy Most potent statin: Pitavastain 