<prompt> Major source of collagen in cirrhosis-Kupfer cellsIto cell Hepatic stellate cellHepatocvteCanalicular cell  <response>: Ans. is b i.e., Ito cell hepatic stellate cell o Perisinusoidal stellate cells Ito cells play a role in the storage and metabolism of vitamin A and are transformed into collagen producing myofibroblasts when there is inflamation of the liver,o These cells are the major source of colieeen in cirrhosis. 