<prompt> All are side effects of clomiphene citrate except ?Ovarian cystsHot flushesBreast sorenessAmenorrhea  <response>: Ans. is d i.e., Amenorrhea Clomiphene citrate It is a nonsteroidal compound. It is binds to both estrogen receptor a ERa and ER13 It acts as a pure estrogen antagonist in all human tissues. Induces gonadotropin secretion LH, FSH by blocking estrogenic feedback inhibition on pitutary not on hypothalamus. In response to increased LHFSH ovaries enlarge and ovulation occurs. Antagonism of peripheral actions of estrogen results in hot flushes. The chief use of clomiphene is in sterlity due to failure of ovulation - Addition of menotropins or chorionic gonadotropin improves the success rate. Other uses are to aid in vitro feilization and oligospermia male infeilty. Adverse effects - Polycystic ovarian disease hyperstimulation syndrome, multiple pregnancy, hot flushes are main. There is increase risk of ovarian tumor Side effects of clomiphene- Polycystic ovary, hyperstimulation syndrome, hot flush, multiple pregnancy, alopecia, veigo, allergic dermatitis, gastric upset and increased risk of ovarian tumor. 