<prompt> Chemical used in vaginal sponge isEthynil estradiolProgesteroneMifepristoneNonoxynol-9  <response>: Vaginal sponge is a small polyurethane foam sponge saturated with spermicide, nonoxynol-9 It comes under barrier method of contraception Reference : Park;s textbook of preventive and social medicine, 23rd edition, Page no: 495 