<prompt> LCAT is activated by?Apo AIApoCIIApo EApo B 100  <response>: Ans. A. Apo AI. Ref Harper Biochemistry 26th48, 206; Harrison 17thpg. 2417; 18thTable 356-2 cApolipo- proteinFunctionChylomicronChylomicron remnantVLDLIDLLDL HDLEMediates remnant uptake A-IActivates LCAT C-IILipoprotein lipase cofactor B-48Mediates chylomicron secretion B-100Binds LDL receptor APOLIPOPROTEINSApo-AI, A-II, A-IVfound in HDL and chylomicronsApo-AI, AII, AIVfound primarily on HDLApo-AI and AIIsynthesized in liver and intestineApo-A IVsynthesized in intestine only.Apo-AIcomprises 70-80 protein of HDL AII: is second most abundant in HDLApo-AILCAT activator and inversely related to CHDB-100Binds to LDL receptor, mediates VLDL secretionB-48mainly Mediates chylomicron secretionC-IICofactor for lipoprotein lipase.EMediates Extra remnant uptakeMajor ApolipoproteinsApolipoproteinPrimary SourceLipoprotein AssociationFunctionApoA-IIntestine, liverHDL, chylomicronsStructural protein for HDL Activates LCATApoA-IILiverHDL, chylomicronsStructural protein for HDLApoA-IVIntestineHDL, chylomicronsUnknownApoA-VLiverVLDL, chylomicronsPromotes LPL-mediated triglyceride lipolysisApoaLiverLpaUnknownApoB-48IntestineChylomicronsStructural protein for chylomicronsApoB-100LiverVLDL, IDL, LDL, LpaStructural protein for VLDL, LDL, IDL, LpaLigand for binding to LDL receptorApoC-ILiverChylomicrons, VLDL, HDLUnknownApoC-IILiverChylomicrons, VLDL, HDLCofactor for LPLApoC-IIILiverChylomicrons, VLDL, HDLInhibits lipoprotein binding to receptorsApoELiverChylomicron remnants, IDL, HDLLigand for binding to LDL receptorApoHLiverChylomicrons, VLDL, LDL, HDLB2 glycoprotein IApoJLiverHDLUnknownApoLUnknownHDLUnknownApoMLiverHDLUnknownEducational points:Fredrickson Classification of HyperlipoproteinemiasPhenotypeIIIaIIbIIIVVLipoprotein, elevatedChylomicronsLDLLDL and VLDLChylomicron and VLDL remnantsVLDLChylomicrons and VLDLTriglycerides N Cholesterol total N LDL-cholesterol HDL-cholesterol N N Plasma appearanceLactescentClearClearTurbidTurbidLactescentXanthomasEruptiveTendon,NonePalmar,NoneEruptive tuberous tuberoeruptive Pancreatitis0000Coronary atherosclerosis0--Peripheral atherosclerosis0--Molecular defectsLPL and ApoC-HLDL receptor, ApoEApoA-VApoA-V and ApoB-100,PCSK9, LDLRAP, ABCG5 and ABCG8 GPIHBP1Genetic nomenclatureFCSFH, FDB,ADH, ARH, sitosterolemiaFCHLFDBLFHTGFHTG 