<prompt> All are true regarding agammaglobulinemia except -Loss of germinal centre in lymph nodeNormal coical lymphocytesNormal coical lymphocytes in paracoex and medullaDecreased red pulp in spleen  <response>: In agammaglobulinemia all classes of immunoglobulins are grossly depleted in the serum. Tonsils Adenoids are atrophic. Lymph node biopsy reveals depletion of cepls of bursa dependent areas. Plasma cells and germinal centres are absent even after antigenic stimulation. There is marked decrease in the poion of B cells in circulation. Ref: Ananthanarayan Panikers textbook of microbiology 9th edition pg.no. : 171,172 