<prompt> Which of the following dermatological condition is associated with mutation in K1 Keratin 1 and K10 Keratin 10 genes?Epidermolysis bullosa simplexEpidermolytic hyperkeratosisEpidermolytic palmoplantar keratodermaMeesmann epithelial corneal dystrophy  <response>: Mutations in keratins K1 and K10 are associated with bullous congenital ichthyosiform erythroderma BCIE, also sometimes referred to as Epidermolytic hyperkeratosis. Features of Epidermolytic hyperkeratosis: It manifest at bih as generalized erythroderma associated with vesicles and bullae. It then progress to generalized verrucous hyperkeratosis with prominent involvement of flexural areas. Blisters are present in the epidermis. 