<prompt> Which antibody is aw the condition showing following features?Anti ds. DNAAnti-RoAnti CCPAnti SCL - 70  <response>: Systemic Sclerosis Scleroderma Characterized by vascular injury and progressive perivascular and interstitial fibrosis of multiple organs. FemalesMales with age group is 30 to 50 years. Cutaneous involvement is most common. Etiology and pathogenesis Microvascular injury is a hallmark feature of systemic sclerosis. Two clinical categories are: Diffuse scleroderma: Widespead cutaneous involvement. It has two Auto-antibodies: Anti-topoisomerase I anti-Scl-70 antibodies are specific. RNA polymerase III antibodies. 