<prompt> True about senile systemic amyloidosis ?Systemic involvement presentAA amyloidHea failure is predominant presentationTransthyretin  <response>: Ans. is d i.e., TransthyretinSenile systemic amyloidosis SSA SSA is characterized by deposition of wild - type transthyretin TTR - based amyloid in parenchymal organs in elderly individuals.SSA is common disease, affecting approximately 25 of the population greater than 80 years old.SSA is characterized by amyloidosis clinically limited to hea; therefore, initially it was referred to as senile cardiac amyloidosis.o This form of cardiac amyloidosis tends to run a benign clinical course and is not associated with extracardiac manifestations. However, some elderly male patients may have extensive amyloid deposits in the atria, ventricles or hea valves, producing CHF and death. 