<prompt> TSH acting throughIon channelsNuclear receptorscAMPCytoplasmic receptors  <response>: Thyroid-stimulating hormone also known as TSH or thyrotropin is a hormone that stimulates the thyroid gland to produce thyroxine T4, and then triiodothyronine T3 which stimulates the metabolism of almost every tissue in the body. It is a glycoprotein hormone synthesized and secreted by thyrotrope cells in the anterior pituitary gland, which regulates the endocrine function of the thyroid gland. The TSH receptor is a member of the G protein-coupled receptor superfamily of integral membrane proteins and is coupled to the Gs proteins.Ref: Ganong;s review of medical physiology; 24th edition; page no-302 