<prompt> Merkel cell is derived fromEctodermNeural crestMesodermEndoderm  <response>: Skin structures derived from two of three primary germ layers. Ectoderm: epidermis, adnexal structures, Merkel cells, melanocytes neural crest, and nerves neuroectoderm Mesoderm: fibroblasts, LCs, vessels, and inflammatory cells. Ref:- Review of Dermatology by Alikhan; pg num:-11 