<prompt> Which of the following is not an indication of amniocentesis for chromosomal anomaly detection?Gestation diabetesPrevious Downs childMaternal age more than 35Parents with chromosomal anomaly  <response>: Ans, is a, i.e. Gestation diabetesRef. Dutta Obs. 7e, p 647; Fernando Arias 3e, p 46, 47; COGDT 10e, p 107, Williams Obs. 23e, p 299, 300Amniocentesis or chorionic villi sampling should be offered to the following class of patients:-Singleton pregnancy and maternal age 35 years or above.-Twin pregnancy at age over 31 years of pregnancy.-Previous chromosomally abnormal child.-Three or more spontaneous abortions.-Patient or husband with chromosome anomaly.-Family history of chromosome anomaly.-Possible female carrier of X-linked disease.-Metabolic disease risk because of previous experience or family history.-NTD risk because of previous experience or family history.-Positive second-trimester maternal serum screen or major fetal structural defect identified by USG. 