<prompt> Patient comes for blood donation but he has HBs Ag and HBeAg positive, and serum transaminases level is normal. What would be the next step in management?Treat with interferonHBV DNA estimationLiver biopsyObservation  <response>: Since the patient has voluntarily donated blood it implies that he does not have any active liver disease. Recommendations for Treatment of Chronic Hepatitis B HBeAg Clinical HBV DNA ALT Recommendation Reactive Inactive mild disease 2 X 104 2X Upper limit of normal No treatment; monitor. In patients 40, with family history of hepatocellular carcinoma, andor ALT persistently at the high end of the two fold range, liver biopsy may help in decision to treat. Reactive Chronic hepatitis 2 X 104 2X Upper limits of normal Treat Reactive Chronic compensated 2 X 103 Upper limits of normal Treat with oral agents, not PEG IFN Reactive Cirrhosis transplantation Detectable Upper limits of normal Treat with oral agents, not PEG IFN Refer for transplantation for Liver Undetectable Upper Limits of normal Observe; refer for liver transplantation 