<prompt> Most significant contraindication for Fine Needle Aspiration biopsy FNA is:Moribund state of the patientDisseminated malignancyBleeding disorderHIV positivity  <response>: Ans: c. Bleeding disorderRef: British Society for Clinical CytologyContraindication for FNA1. Uncorrected coagulopathies Anticoagulant therapy Intrinsic bleeding disorder2. Parasitic cysts - Chance of anaphylactic shock.3. Cough respiratory infection - Contraindication for transthoracic FNA4. Carotid body tumour - May cause catecholamine release with potential risk of hypertensive crisis. 