<prompt> Most sensitive test for skeletal metastasis isRadio- isotopeTomographyCT scanX-ray  <response>: A. i.e. Radio-isotope 20 - Apley 8th The best indication for a bone scan is suspected multiple bony lesions such as in metastatic carcinoma an lymphoma of bone 302 - current diagnosis Treatment - orthopedics Most common imaging agents are technetium 99 m and indium 111 Tc99m used to assess the degree of osteoblastic activity Tc99m scan are also useful in distinguishing blastic lesions of bone Isotope scaning is also used in the staging process of a primary sarcoma such as an osteosarcoma to make sure the patient does not have an asymptomatic remote skeletal lesions 