<prompt> Acute Hepatitis B can be earliest diagnosed by ?IgM anti HBc abHbs AgIgC anti HBc absAnti HBs Ag ab  <response>: Ans. is a i.e., IgM anti HBc Ab . This is controversial question. . Some people including me are in our of IgM anti HBc abs, while other think HBs Ag is the correct answer. . With HBs Ag one can make the diagnosis of HBV infection, but to confirm acute infection, IgM anti HBc is required. See following question of AIIMS 2006. A 30 years old patient presented with history of jaundice for 10 days. His liver function tests showed bilirubin of 10 mgdl, SGOTSGPT - 11001450, serum alkaline phosphatase - 240 IU. He was positive for Hbs Ag. What should be the confirmatory test to establish acute hepatitis B infection ? a Ig M anti-HBc antibody correct answer b Hbe Ag c HBV DNA by PCR d Anti - HBc antibody . When examinar himself giving us answer in the question, why should we create controversy ? . For confirmation of acute infection, we have to do Ig M anti HBc. 