<prompt> A drug having 40 absorption and hepatic extraction ratio of 0.6. What is the bioavailability of that drug?16242028  <response>: Ans. is a i.e., 16 Absoion of drug is 40 i. e. if 100 mg of drug is taken 40 mg will be absorbed. Hepatic extraction ratio is 0.6 i.e. out of the absorbed dose 60 will be removed by liver; so from the absorbed 40 mg 60 removed i. e. 24 mg removed. Thus finally the remaining 16 mg of the total dose taken reaches the systemic circulation. So bioavailability is 16 as 16mg of the total 100 mg finally reached the systemic circulation 