<prompt> In renal failure, metabolic acidosis is due to ?Increased H productionLoss of HCOfDecreased ammonia synthesisUse of diuretics  <response>: Ans. is c i.e., Decreased ammonia synthesis The predominant reason for metabolic acidosis in C.R.F. is decreased ammonia production.o Metabolic acidosis is a common disturbance in advanced chronic kidney disease The majority of patients can still acidly the urine but theyproduce less ammonia and, therefore, cannot excrete the normal quantity of protons in combination with this urinary buffer. 