<prompt> Major in vivo pathway of coagulation -Contact pathwayIntrinsic pathwayExtrinsic pathwayNone of the above  <response>: Ans. is c i.e., Extrinsic pathwayo Blood coagulation pathways are divided into :-i Intrinsic pathway contact pathway: It is largely an in vitro pathway and is activated when factor XII Hageman factor or contact factor comes in contact with negatively charged surface, e.g. glass, kaolin etc.ii Extrinsic pathway: It is largely an in vivo pathway is activated by tissue factor thromboplastin at the site of tissue injury. 