<prompt> Which one of the following is the major site for Purine nucleotide biosynthesis?LiverErythrocytesPolymorphonuclear leukocytesBrain  <response>: Liver is the major site for Purine nucleotide biosynthesis. Erythrocytes, Polymorphonuclear leukocytes and Brain cannot produce purines. The purines are built upon a pre-existing ribose 5-phosphate. 