<prompt> The dose of folic acid per day for treating megaloblastic anaemia in pregnancy400 μg1 mg5mg2 mg  <response>: Folic acid deficiency in PregnancyIn nonpregnant women, the folic acid requirement is 50 to 100 μgdayDuring pregnancy, requirements are increased and 400 μgday is recommended The earliest biochemical evidence is low plasma folic acid concentrations Normal serum folate levelsNon Pregnant women: 5.4-18ngml1st trimester: 2.6-15ngml2nd trimester: 0.8-24ngml3rd trimester: 1.4-20.7ngmlEarly morphological changes usually include neutrophils that are hypersegmented and newly formed erythrocytes that are macrocytic As the anaemia becomes more intense, peripheral nucleated erythrocytes appear, and bone marrow examination discloses megaloblastic erythropoiesisThe fetus and placenta extract folate from maternal circulation so effectively that the fetus is not anaemic despite severe maternal anaemiaTreatment As little as 1mg of folic acid administered orally once daily produces a striking haematological responseBy 4 to 7 days after beginning folic acid treatment, the reticulocyte count is increased, and leukopenia and thrombocytopenia are correctedAmerican College of Obstetricians and Gynecologists 2013c have recommended that all women of childbearing age consume at least 400 μg of folic acid dailyIncreased need of Folic acidMultifetal pregnancyHemolytic anaemiaCrohn diseaseAlcoholismInflammatory skin disorders 