<prompt> Most common cause of hereditary spherocytosis?ActinGlycophorinSpectrin-Ankyrin complexBand 4  <response>: About 60 of HS cases results from a defect in the ankyrin-spectrin complex , with genes for a or b subunits of spectrin dimer SPTA1 ,SPTB or for ankyrin ANK1being implicated in diff genetic type. 25 involve deficiency in band 3, the anion channel. Ref:Postgraduate Hematology by Victor Hoffbrand ,pg:131 Ref Robbins 9e pg 412 