<prompt> The genetic defect in Dubin-Johnson Syndrome isMutation in gene for multiple drug resistance protein 2Mutation in gene UDP- glucuronyl transferaseMutation of chromosome 23Flash mutations  <response>: Dubin-Johnson syndrome is a rare, autosomal recessive, benign disorder that causes an isolated increase of conjugated bilirubin in the serum. Classically, the condition causes a black liver due to the deposition of a pigment similar to melanin. Refer robbins 9e 