<prompt> Wire loop thickening of glomerular basement membrane is seen in -Systemic lupus erythematosus SLENon Insulin Dependent Diabetes MellitusRapidly progressive glomerulonephritisMalignant hypeension  <response>: Ans. is a i.e., Systemic lupus erythematosus o Wire loop thickening is a characteristic features of lupus nephritis. o It occurs because extensive subendothelial deposit in kidney causes a peculiar thickening of the capillaries which on light microscopy appear as wire loop lesions. o Wire loop lesions indicate active disease and poor prognosis. o Wire loop lesions are especially common in diffuse proliferative glomerulonephritis, but can also occur in focal proliferative and membranous glomerulonephritis. 