<prompt> True about Sickle cell disease are all, Except:Single nucleotide change results in change of Glutamine to ValineSticky patch is generated as a result of replacement of a non polar residue with a polar residueHbS confers resistance against malaria in heterozygotesRFLP results from a single base change  <response>: Sticky patch is generated as a result of replacement of a non polar residue with a polar residue Repeat from May 11 Sticky patch in sickle cell disease results from replacement of a polar residue Glutamate with a non polar residue Glutamate is ---Polar Mnemonic: GP i.e. General Practioner Valine is Non Polar Valine at the 6th position of the beta chain. 