<prompt> Abnormally high LAP score is seen in -Polycythemia veraCMLPNHAll  <response>: Answer is option 1, polycythemia SECTIONS Approach Considerations The Polycythemia Vera Study Group PVSG was the first to set rigorous criteria for the diagnosis of polycythemia vera PV in the 1970s. With the establishment of polymerase chain reaction PCR-based methods for detecting the JAK2 V617F mutation, this may become the first molecular diagnostic marker for PV, similar to BCRABL for chronic myelogenous leukemia CML. However, because of a paucity of centers doing red blood cell mass measurements, demonstrating an elevated red blood cell mass continues to become more difficult. The diagnostic criteria set by the PVSG are organized into two categories, A and B. The diagnosis of PV is established if all three category A criteria are present, or if criteria A1 plus A2 plus any two criteria from category B are present. Category A criteria are as follows: Total red blood cell mass 36 mLkg in males or 32 mLkg in females Aerial oxygen saturation 92 Splenomegaly Category B criteria are as follows: Thrombocytosis, with platelet count 400,000mL Leukocytosis, with a white blood cell count 12,000mL Increased leukocyte alkaline phosphatase ALP 100 UL emedicine.medscape.com 