<prompt> Which of the following statements are true about mifepristone :Also called RU -- 486It is a 19 -- norsteroidActs on receptorsAll  <response>: Ans. is a, b, c Also called RU - 486; It is a 19 Norsteroid; Acts on receptors; Used for menstrual regulation Route of administration : Oral RU 486 Mifepristone is a 19 Norsteroid synthetic derivative of progesterone. It has affinity for progesterone receptors and therefore blocks its actions. Uses : As post coital 600mg given within 72 hrs. of unprotected sex. To induce aboion upto 7 weeks of amenorrhea along with mesoprostol medical aboion. Ripening of cervix prior to prostaglandin induction of mid trimester aboion. Management of ectopic pregnancy. Cushings syndrome : because of its antiglucocoicoid action. Medical management of uterine fibroid. Headache GI upset Adrenal failure Teratogenesity If medical methods of aboion fails with RU - 486, pregnancy should be terminated any how. Contraindication : Adrenal failure Cardiac disease Asthma Haemorrhagic disease Glucoma Woman on long term glucocoicoid therapy and anticoagulants. 