<prompt> Cyclo-oxygenase-1 COX-1 isoenzyme:Is increased by inflammationIs predominant mode of action of IndomethacinIs increased by lipopolysaccharide ie G ve endotoxinIs NOT involved in gastric mucosal protection  <response>: Option A, C E is incorrect as Cyclo-Oxygenase -1 COX-1 is a constitutive Enzyme.Option B is correct as Indomethacin does affect it as its nonselective.Option D is incorrect as COX-1, plays a central role in protection of the gastric mucosa, by helping in the synthesis of Prostaglandins. 