<prompt> Gall stones in sickle cell anemia are made up of?CholesterolCalcium carbonateBilirubinNone  <response>: Ans. is c i.e. Bilirubin In sickle cell disease, chronic hemolysis with its accelerated bilirubin turnover leads to a high incidence of pigment gallstones. They are composed primarily of bilirubin insoluble bilirubin pigment polymer and calcium calcium phosphate salts that are found in bile. 