<prompt> HRT improves -Bone densityCoronary art disDementiaEndometrial cancer  <response>: Ans. is a i.e., Bone density Indications of HRTTherapeutico Symptoms of oestrogen deficiencyo Gonadal dysgenesis in adolescentsProphylactico High risk cases for menopausal complications such as CVD, osteoporosis decreased bone density, stroke, Alzheimer disease, colonic cancero Premature menopause, spontaneous or following surgery hysterectomy, tubectomyo Menopause caused by radiotherapy or chemotherapy for cancerComponents of HRTEstrogenProgestino Oral or transderma!o Given in conjunction with oestrogen in women with an intact uterus to decrease the risk of endometrial carcinomao Transdermal is preferred for women with hvpertryglyceridimia or impaired hepatic functions o Given alone in women who have undergone hysterectomy Side effectso Abnormal uterine bleedingo Mastodyniao Edema, bloating, heart bum and nauseao Mood changes worsen in progesterone phase of combined therapyRisksUncertainCertaino Thromboembolic events with combination therapyo Coronary heart diseaseo Dementiao Breast cancer with combination therapyo Endometrial cancer only with use of estrogeno Strokeo Ovarian cancer with combination therapyo Cholecystitis 