<prompt> Which of the following is used in the treatment of Multiple Sclerosis:Interferon AlphaInterferon BetaInfliximabInterferon gamma  <response>: Answer is B Interferon Beta : Interferon Beta should be considered in patients with Relapsing Remitting MS RRMS and Secondary Progressive MS SPMS with superimposed relapses. Interferon Beta reduces the attack rate in M.S. patients and also improves disease severity measures and disease burden. Interferons Interferons are cytokines that exhibit antiviral activities, immunomodulating propeies and antiproliferative propeies. DNA recombinant technology has made available highly purified a, 3 and y interferons. IFNs are not available for oral administration but must be given intramuscularly, subcutaneously or intravenously. Interferon Alpha IFN a Interferon Beta HENi Interferon IFN y Considered for : Considered for : Considered for : Hepatitis B, Hepatitis C Multiple Sclerosis Osteopetrosis , H 2282 Mucocutaneous manifestations of suggested benefit Behcets syndrome H 2014 3 Approved Agents Systemic sclerosis H1987 Carcinoid syndrome H 2226 Aronex IFN 3la modest improvement but recurrence Chronic myeloid leukaemia CML H Rebif IFN 3 I a Idiopathic pulmonary fibrosis 640 Betaseron IFN 31b therapeutic trial H 1556 Follicular lymphoma H 651 Malignant melanoma Chronic granulomatous disease leprosy, non tuberculosis mycobacteria visceral Adjuvant H 502 leishmaniosis H357 Essential thrombocytosis Multiple myeloma H 660 Renal cell carcinoma H 542 Splenornegaly H 628 Also Note : Interferon is not curative for any tumor but can induce paial responses in Harrison 16th 482 Follicular lymphoma Hairy cell leukaemia CML Melanoma Kaposis sarcoma IFN y has been successfully used in the treatment of Leprosy, Nontuberculous Mycobacteria and Visceral Leishmaniosis. - Harrison I6th 357 