<prompt> A 45 year old female was diagnosed with breast carcinoma. She was operated and is taking tamoxifen therapy for the last 1 year. Now she is complaining of bleeding per vaginum. If this is due to the adverse effect of tamoxifen, the most likely cause is:-Development of bleeding disorderDevelopment of endometrial carcinomaDevelopment of ovarian carcinomaDevelopment of cervical cancer  <response>: - Tamoxifen and Toremifene are selective estrogen receptor modulators SERMs that are useful for chemoprevention as well as treatment of both early stage and metastatic breast carcinoma. - These increase the risk of endometrial carcinoma. 