<prompt> A 6 month child presents with episosdes of vomitting after ingesting fruit juice. Which of following enzyme deficiency is likely ?Aldolase BFructokinaseGlucose 6 phosphataseHexokinase  <response>: The condition is hereditary fructose intolerance,an autosomal recessive inborn error of metabolism,due to defect in aldolase-B or fructose-1-phosphate aldolase.Hence,fructose -1-phosphate cannot be metabilised.This is seen when sucrose containing fructoseeg.,fruit juices is introduced in the diet of infants,usually around 6 months of age.Accumulation of fructose-1-phosphate will inhibit glycogen phosphorylase.This leads to accumulation of glycogen in liver and associated hypoglycemia.Vomiting and loss of appetite are seen.The infants often fail to thrive.Hepatomegaly jaundice may occur.If liver damage progresses,death will occur.Withdrawal of fructosefruit juicesfrom the diet will immediately relieve the symptoms. Reference:Textbook of biochemistry-DM Vasudevan,6 th edition,page no:120. 