<prompt> Drug not given for malaria prophylaxis is?ChloroquineProguanilDoxycyclineAesunate  <response>: Aesunate REF: Types of malaria prophylaxis: A Primary Prophylaxis: Use of anti-malaria drugs at recommended dosage, staed 2-20 days before depaure to a malarious area and continued for the duration of stay and for 1-4 weeks after return. Causal prophylaxis: This prevents the establishment of infection in the liver by inhibiting the pre-erythrocytic schizogony. Primaquine and proguanil are effective as causal prophylactic drugs. Suppressive prophylaxis: Use of blood schizonticides suppresses the blood forms of the malaria parasite and thus protects against clinical illness. However, P. vivax and P. ovale may cause relapses from the hypnozoites and to prevent this, terminal prophylaxis may be needed. B Terminal Prophylaxis: Terminal prophylaxis is the administration of Primaquine for two weeks after returning from travel to tackle the hypnozoites of P. vivax and P. ovale that can cause relapses of malaria. It is indicated only for persons who have had prolonged exposure in malaria-endemic regions, such as expatriates and long-term travellers like missionaries and Peace Corps volunteers. Primaquine is administered after the traveller leaves an endemic area and usually in conjunction with Chloroquine during the last 2 weeks of the 4-week period of prophylaxis after exposure in an endemic area has ended Drugs used in malaria prophylaxis and their doses: Drugs Dosage Pros and Cons Adults Children Atovaquone plus Adult Pediatric tablet of 62.5 Daily dosing; only have to ProguanilMalarone tablet of mg atovaquone and 25 mg continue for 7 days after 250 mg proguanil: exposure; not in pregnancy and atovaquone and 100 mg proguanil - 1 tab. daily 5-8 kg: 12 tablet daily 8-10 kg: 34 tablet daily 10-20 kg: 1 tablet daily 20-30 kg: 2 tablets daily lactation 30-40 kg: 3 tablets daily 40 kg: 1 adult tablet daily Chloroquine 300 mg base 5mgkg base weekly; Long-term safety known; Tablet with 150mg base once weekly maximum 300 mg Chloroquine resistance repoed from most pas of the world; not for persons with epilepsy, psoriasis Proguanil 200 mg daily 2 yrs: 50 mgday; Used in combination 2-6 yrs:100 mgd 7-9 yrs: 150 mgday; 9 yrs: 200 mgd Doxycycline100mg 100mg once 1.5mg basekg once daily Daily dosing required; not in daily max. 100 mg pregnancy and lactation 25kg or 8 yr: Not given 25-35kg or 8-10 yr: 50mg 36-50kg or 11-13 yr: 75mg 50kg or 14 yr: 100mg MefloquineTablet with 250 mg base 15 kgs: 5mg of saltkg; Weekly dosing; occasional repos 250mg base, 274mg salt once weekly 15-19 kg: tabwk; 20-30 kg: 12 tabwk; 31-45 kg: 34 tabwk; 45 kg: 1 tabwk of severe intolerance; not in first trimester of pregnancy, breast feeding, high altitudes or deep sea diving, patients with epilepsy, psychosis, hea blocks, receiving 13 blockers 