<prompt> Bisphoshonates are prescribed to a patient with the following adviceTake empty stomach with plenty of waterTake after mealsDuscintunes if gastritis developsDiscontinues if severe bone pain occurs  <response>: Refer KDT 7th345 Bisphoshonates are to be taken empty stomach in the morning with full glass water and patient is instructed not to lie down or take food for at least 30 min. These measures are required to prevent contact of the drug with esophageal mucosa which result in esophagitis 