<prompt> Following is called gatekeeper of colonic neoplasiaAPCSMAD2PTENSTK11  <response>: Adenomatous polyposis coli APC gene Chr 5q21 Gate-keeper of colonic neoplasia Component of WNT signalling pathway Controls cell fate, polarity and adhesion during embryonic devt Controls oncogenic effect of b catenin Germline LOF mutation - Familial Adenomatous Polyposis Colon Cancer AD Other tumours - hepatoblastoma, HCC 