<prompt> Best marker of SLE?Anti Sm antibodiesAnti-ds DNA antibodiesAnti-Histone antibodiesAnti Ro SS-A antibodies  <response>: Ans. b Anti-ds DNA antibodiesRef: Harrison 18thchapter 319Anti dsDNA is specific for SLE, only in high titers;But still, anti ds DNA is the best marker for SLE because its prevalence in SLE is 70;Whereas, Anti Sm antibody, which is specific for SLE, but is seen in only 25 patients with SLE 