<prompt> The following is a marker of acute hepatitis B infection:DNA polymeraseHepatitis core antigenAnti HBsIgG to core antigen  <response>: HBV-DNA can be measured by PCR in the blood. Viral loads are usually in excess of 105 copiesmL in the presence of active viral replication, as indicated by the presence of e antigen. In contrast, in individuals with low viral replication, who are HBsAg- and anti-HBe-positive, viral loads are less than 105 copiesmL.Reference: : Davidson P R I N C I P L E S and Practice O F M E D I C I N E 23rd edition page no 875 