<prompt> Anti Topoisomerase I Scl-70, anti-RNA polymerase III positivity is classically seen with:Limited cutaneous sclerosisDiffuse cutaneous sclerosisCREST syndromeSSc sine scleroderma  <response>: Diffuse systemic sclerosis Skin involvement- usually Rapid onset. Diffuse and with rapid progression Raynauds phenomenon- Onset coincident with skin involvement-mild Musculoskeletal-Severe ahralgia, carpal tunnel syndrome Pulmonary fibrosis-Frequent, early and severe Pulmonary hypeension-May occur, often in association with pulmonary fibrosis Scleroderma renal crisis-Occurs in 15; early Calcinosis cutis-May occur, mild Characteristic autoantibodies-Anti Topoisomerase I Scl-70, anti-RNA polymerase III CREST syndrome-A subset of patients with limited systemic sclerosis a calcinosis cutis, b Raynauds phenomenon, c esophageal dysmotility, d sclerodactyly e telangiectasia Raynauds phenomenon and other typical features of systemic sclerosis occur in the absence of detectable skin thickening in some patients. This syndrome is been termed SSc sine scleroderma. Ref: Harrison,E-18,P- 2758. 