<prompt> True about smoldering myeloma is:Monoclonal gammopathyLytic bone lesionHypercalcemiaBone Marrow Plasma cell 10  <response>: Answer is A Monoclonal gammopathy Smoldering myeloma is a variant of multiple myeloma and is associated with a monoclonal gammopathy Smoldering Myeloma Smoldering Myeloma is an asymptomatic variant of multiple myeloma Monoclonal gammopathy These patients have a higher levels of M-component and marrow plasmacytosis than patients with MGUS Monoclonal Gammopathy of Unknown Significance, and fulfill the minimal criteria for diagnosis of plasma cell myeloma, but are asymptomatic and have no lytic bone lesions or other clinical features of Myeloma. Diagnostic Criteria for Smoldering Myeloma Asymptomatic Myeloma M protein is serum 30gL 3gdl Bone marrow clonal plasma cell Plasmacytosis 10 No myeloma related organ or tissue impairment No lytic bone lesions No myeloma related symptoms - No renal insufficiency - No Anemia - No Hypercalcemia Comparisonof MGUS, Indolent myeloma and Smoldering myeloma: MGUS SMM IMM Multiple Myeloma Plasma cell BM 10 10-30 30 30 M-component IgG3.5, IgA2 IgG3.5, IgA2 IgG 3.5-7, IgA 2-5 IgG 3.51d1; IgA 2gdl Lytic bone lesion None None 3 Present SymptomsInfection - Anemia - Renal insufficiency - Hypercalcemia None None None Present 