<prompt> Alpha antitrypsin is synthesized in :BrainLiverSpleenKidney  <response>: 1-Antiproteinase about 52 kDa was formerly called 1-antitrypsin, and this name is retained here. It is a single-chain protein of 394 amino acids, contains three oligosaccharide chains, and is the major component 90 of the 1 fraction of human plasma. It is synthesized by hepatocytes and macrophages and is the principal serine protease inhibitor serpin, or Pi of human plasma. A deficiency of this protein has a role in ceain cases approximately 5 of emphysema.Deficiency of 1-antitrypsin is also implicated in one type of liver disease. Ref: Murray R.K., Jacob M., Varghese J. 2011. Chapter 50. Plasma Proteins Immunoglobulins. In D.A. Bender, K.M. Botham, P.A. Weil, P.J. Kennelly, R.K. Murray, V.W. Rodwell Eds, Harpers Illustrated Biochemistry, 29e. 