<prompt> Which of the following tumor suppressor genes act by inhibition of Hedgehog signaling pathway?PTCHSDHBBRCA1CDKN2A  <response>: Tumor suppressor genes and associated Familial Syndromes and Cancers -PTCH:-Gene acts by inhibiting Hedgehog signaling pathway Patched protein Causes:- Gorlin syndrome BCC, Medulloblastoma,severe benign tumor -SDHB:-Inhibitors of Pro-growth programs of Metabolism and Angiogenesis Succinate dehydrogenase complex subunits B and D Causes:-Familial paraganglioma, familial pheochromocytoma -CDKN2A:-Inhibitors of cell cycle progression, causes Familial melanoma -BRCA1:-DNA Repair factors, causes Familial breast and ovarian carcinoma; carcinomas of male breast 