<prompt> Side effect of oral carbonic anhydrase inhibitors include ?Weight gainInsomniaHyperkalemiaParesthesia  <response>: Ans: D. ParesthesiaRef KDT Vhe p. 5g7; Clinical pharmacology 8the p. 71gAdverse effects of systemicoral carbonic anhydrase inhibitors are:CNS effects: Lethargy, drowsiness, headache, seizures, and ParesthesiasGI effects: Nausea, vomiting, diarrhea, altered taste, and anorexiaDiuretic effect : Polyuria and increased thirst; fluid and electrolyte disturbances hypokalemia, metabolic acidosisWorsening of liver disease : Precipitation of hepatic encephalopathy hepatic coma and hepatic necrosisHypersensitivity reaction: In patients sensitive to sulfonamide CAase inhibitors are sulfonamide derivativesHyperuricemia: Precipitation of goutBone marrow depression: Rare 