<prompt> Spironolactone should not be given withChlohiazideBeta blockersACE inhibitorsAmlodipine  <response>: Sprinolanctone is a potassium sparing diurectic It doesnt excrete potassium - increasing potassium levels in the blood ACE IN. also increases potassium levels in the blood Hence the combination is contraindicated Ref: KD Tripathi 8th ed 