<prompt> True about imipenem is -It is a narrow spectrum antibioticIt is easily broken by beta lactamIt can be used with cilastatinIt is used with sulbactam  <response>: Ans. is c i.e., It can be used with cilastatin o A limiting feature of imipenem is its rapid hydrolysis by the enzyme dehydropeptidase-I located on the brush border of renal tubular cells. Cilastatin is a reversible inhibitor of dehydropeptidase -1. It protects the imipenem from this enzyme. o Carbapenems have the widest spectrum of all currently available antimicrobials, being bactericidal against most gram positive andgram negative aerobic and anaerobic pathogenic bacteria. 