<prompt> SCD is caused by a recessive, single-nucleotide mutation in the beta globin gene of Hgb. All of the following are TRUE about Sickle cell disease, EXCEPT:Single nucleotide change results in change of Glutamine to ValineSticky patch is generated as a result of replacement of a non polar residue with a polar residueHbS confers resistance against malaria in heterozygotesRFLP results from a single base change  <response>: When the sickle Hgb unloads its O2, the normal conformational change exposes the valine at position 6 to the surface creating a hydrophobic sticky patch. The hydrophobic patch on one deoxygenated Hgb molecule can interact with the hydrophobic patch on a second Hgb molecule, creating stiff Hgb polymers. These internal polymers cause the RBC to stiffen and adopt abnormal shapes, including a crescent or sickle shape that gives the disease its name. Ref: Poeus M., Mantanona T. 2012. Chapter 14. Blood. In L.W. Janson, M.E. Tischler Eds, The Big Picture: Medical Biochemistry. 