<prompt> Which of the following mutation is seen in Cowden syndrome?STK 11 mutationSMAD 4 mutationPTEN mutationPTCH mutation  <response>: Mutation in PTEN gene: Breast tumors Endometrial tumors Skin appendage tumors Thyroid tumors Cowden syndrome: Dysplastic gangliogliocytoma of the cerebellum Lhermitte Duclos disease, caused by mutations in PTEN resulting in PI3KAKT signaling pathway PTEN 