<prompt> Which of the following is associated with destruction of myenteric plexus?Hirschsprung diseaseSecondary AchalasiaHPSSGIST  <response>: 12 Ans. is b i.e., Secondary achlasia Secondary achalasia may arise in Chagas disease, in which Trypanosoma cruzi infection causes destruction of the myenteric plexus, failure of peristalsis, and esophageal dilatation. 