<prompt> Most common defect in hereditary spherocytos is in -SpectrinAnkyrinBand 3Band 4.2  <response>: Ans. is b i.e., Ankyrin Hereditary spherocytosis is caused bv a variety of molecular defects in genes that code for any of the followingAnkyrin - Most common chief component responsible for biconcave shapeBand 3 - Second most commonSpectrinBand 4.2 