<prompt> The type of hemoglobin that has least affinity for 1, 3- Diphosphoglycerate 2,3-DPG or 2, 3-BPG isHg AHg FHBHg A2  <response>: Fetal hemoglobin has least affinity for 13diphosphoglycerate Ref: guyton and hall textbook of medical physiology 12 edition page number: 312,313,314 