<prompt> Multidrug Resistance Tuberculosis MDR-TB should be considered in patients with:Contact with a known case of MDR TBClinical DeteriorationSputum smear positive at 5 months of treatmentAll of the above  <response>: Answer is D All of the above: Infection Control In The community by Lawrence May 2003 All of the options require consideration for a diagnosis of MDR - TB. Mult Drug Resistant Tuberculosis MDR TB MDR-TB is defined by the presence of resistance to both Rifampicin and Isoniazid with or without other resistance MDR TB should be considered in patients with: Previous drug treatment for tuberculosis Contact with a case of known MDR TB HIV infection Failure of clinical response on treatment Prolonged sputum smear or culture positive while on treatment smear positivity at 4 months or culture positivity at 5 months 