<prompt> Patient diagnosed as squamous cell intraepithelial lesion which of the following has the highest risk for progression to carcinoma;Low grade squamous intraepithelial neoplasiaHigh grade squamous intraepithelial neoplasiaSquamous intraepithelial associated with HPV 16Squamous intraepithelial neoplasia associated with HIV  <response>: High grade squamous intraepithelial lesion have a propensity to progress and become invasive, therefore need investigations and treatment Ref: Shaw Gynecology 17 e pg 410. 