<prompt> Most common site of colon malignancy isSigmoid colonAsending colonDescending colonTransverse colon  <response>: A. i.e. Sigmoid colon 1179-B L 25th 696 - CSDT 12th 1060- S. Das 5thSigmoid colon is the most common site Distribution of colorectal cancerRectum 38 Sigmoid colon 21 caecum 12 Transverse colon 5.5 Ascending colon 5 Descending colon 4 Hepatic flexure 2 and anus 2 Appendix 0.5 Sigmoid colon segment of colon undergoes maximum postprandial contractionRight colonLeft colonRectumUnexplained weakness or Iron deficiency anemia Most common Occult blood in feces Dyspeptic symptoms Persistent right abdominal discomfort Change in bowel habits Gross blood in stool Obstructive symptom Tenesmus Characteristic x-ray finding Rectal bleeding alternation in bowel habits Sensation of incomplete evacuation Intrarectal palpable tumor Sigmoidoscopic finding Metastatic disease - Jaundice, ascitis, hepatomegaly Carcinoma of the colon - particularly the right colon is more common in women Carcinoma of the rectum is more common in men Regional lymph node involvement is the most common form of metastasis in colo rectal carcinoma. Marker for Gastro intestinal stromal tumour GIST is CD-I 17 High fibre diet is most protective against development of colorectal cancerRisk factor for Development of colorectal cancer 574 - H17th Diet - Animal fat Streptocccus bovies bacteremia Hereditary syndrome AD- Inheritance Ureterosigmoidostomy Polyposis coli Tobacco-use Nonpolyposis syndrome Lynch syndrome Inflammatory bowel syndrome 