<prompt> Which of the following is not a major criteria for diagnosis of multiple myeloma ?Lytic bone lesionsPlasmacytoma on tissue biopsyBone marrow plasmacytosis 30M spike 3g for 1g G, 2g for IgA  <response>: In the NCCN guidelines, active multiple myeloma is no longer diagnosed using the CRAB criteria hyperCalcemia, Renal failure, Anemia, Bone lesions for end-organ damage. The current diagnostic criteria are as follows : Bone marrow clonal plasma cells 10 or bony or extramedullary plasmacytoma confirmed by biopsy 