<prompt> AML transformation common inAplastic anemiaMDSMegakaryocytic thrombocytopeniaCLL  <response>: Aplastic anemia to AML Aplastic anemia AA is a clinical syndrome of peripheral blood pancytopenia and a hypocellular bone marrow. Immunosuppressive therapy is a key treatment strategy for AA. Genomic instability in AA does not appear to be a rare event. AA evolves into acute myeloid leukemia AML in 5-15 of all cases Ref Davidson 23rd edition pg 969 