<prompt> Bcl-2 isPro-apoptoticAnti-apoptoticProtein synthesisGene amplification  <response>: B Anti-apoptotic The two main anti-apoptotic proteins are Bcl-2 and Bcl-x. These anti-apoptotic proteins normally reside in mitochondrial membranes and the cytoplasm. When cells are deprived of survival signals or subjected to stress, Bcl-2 andor Bcl-x are lost from the mitochondrial membrane and are replaced by pro-apoptotic members of the family, such as Bak, Bax, and Bim. When Bcl-2Bcl-x levels decrease, the permetability of the mitochondrial membrane increases, and several proteins that can activate the caspase cascade leak out. 