<prompt> Most common presentation of neuroblastoma is ?Lytic lesion in skull with suture diasthesisLung metastasisRenal invasionSecondaries in brain  <response>: Ans. is a i.e., Lytic lesions in skull, with sutural diastasis Most frequent site of metastasis from nueroblastoma is bone : where metastasis occurs very early. Lytic lesions in skull and sutural diastasis are manifestations of bony metastasis to skull, and hence the earliest feature, amongst the options in the questions. 