<prompt> Commonest manifestation of retinoblastoma isPseudohypopyonLeukocoriaSquintNystagmus  <response>: Refer: AK Khurana Comprehensive Ophthalmology, 6th edition, pg no. 303 Leukocoria or amaurotic cats eye reflex this is the most common manifestation. The leukocoria or the white glow in the pupil is caused by reflection of light from the white intraocular tumor Leukocoria. Leukocoria also white pupillary reflex is an abnormal white reflection from the retina of the eye. Because of the potentially life-threatening nature of retinoblastoma, a cancer, that condition is usually considered in the evaluation of leukocoria. 