<prompt> A.M.L. with worst prognosis821 translocationInversion 16Normal cytogeneticsMonosomy 7  <response>: Monsomy 7 Ref Harrison 17the p 680 lehe p 6341 There are number of factors which determine the prognosis in A.M.L. In a number of studies in last 2 decades it has been observed that cytogenetic markers are major determinants in assessment of prognosis. Prognosis of Acute Myeloid leukemia . t 8 ; 21,Q Good prognosis inv 16 ordeg . t 15 ; 17Q Moderately ourable outome . No cytogenetic abnormalitydeg . inv 3,deg Monosomy 7 presence deg of PTD of MLL or 1TD of FLT 3 Poor prognosis . Uq 23,deg . 3q21,deg . 3q26deg Prognostic factors in Acute Myeloid leukenia Factors Favorable Unorable . Age 45 years 2 year, 60 years . Leucocytosis 25 x RPLQ 100 x lOYL . CNS involvement AbsentQ Present . Response to therapy Rape Delayedincomplete . Auer rods Present Absent . FAR type M2, B3 M4E0 M5, M6, M7 . Cell markers CD2or CD19 CD13, CD14, CD33 . Cytogenetics t 15:17Q in M3 -7; del 7q, -50 t 8:21 in M2 del sqQ, 11q23 inv 16 del16q abnormalities 3q21 and 3q26 abnormalities complex karyotypic abnormalities 