<prompt> Ca breast in females is least related toBRCA-1BRCA-2Li Fraumeni syndromeAtaxia telangiectasia  <response>: Mutation of tumour suppressor genes BRCA1 BRCA2 is thought to be involved with high risk of breast carcinoma. BRCA1 mutation is having more risk 35-45 than BRCA2 mutation. BRCA1 is located in the long arm of chromosome 17, whereas BRCA2 is located on the long arm of chromosome13. Li-Fraumens syndromeLFS is autosomal dominant condition with breast cancer inheritance90. Breast cancer is also associated with ataxia telangiectasia. But comparing others it is least related to. Reference: SRBs Manual of Surgery, 6th Edition, page no 522. 