<prompt> A 20 yr old female presents with primary amenorrhea. She has low LH, FSH, estrodial levels. She has anosmia and no secondary sex characteristics on examination. What is the likely diagnosis?Kaagener syndromeKallman syndromeAlpos syndromeNone  <response>: Kallmann syndrome Kallmann syndrome is caused from defective gonadotropin releasing hormone GnRH synthesis. Clinical features- Anaemia hyposmia due to olfactory bulb agenesis hypophasia. Color blindness, optic atrophy, nerve deafness. Cleft palate, cryptoorchidism mirror movements neurological defects In males- delayed pubey, micropenis. In females- primary amenorrhea, failure of secondary sexual development. Low LH FSH levels sex steroids. 