<prompt> Which drug can be used in patient of CML with T315i mutation?ImatinibNilotinibDasatinibPonatinib  <response>: Drugs against CML with T315I : Omacetaxine Ponatinib In CML there is BCR-ABL fusion , due to which there is hyperactivation of tyrosine kinase. ABL-BCR tyrosine kinase inhibitors: First generation: Imatinib, Second generationactive against Imatinib resistant cases: Dastanib, Nilotinib. Third generation: Bosutinib, Ponatinib Ponatinib is the only TK inhibitor which is active against CML wth T315I mutation. 