<prompt> True about hemochromatosis is -Iron deficiency anemia is causedKayser Fleischer ring is seen in eyesDM and slate grey discolouration of skinAutosomal dominant is the most common form  <response>: C DM and slate gray discoloration of the skin 42, 627 Harsh Mohan 6th 629 Robbins Basic pathology 9thHemochromatosisTRIAD:1 Pigmentary liver cirrhosis.2 Diabetes mellitus Pancreatic damage3 Skin PigmentationBRONZE DIABETES The most common form is an autosomal recessive disease of adult onset caused by a mutation in the HFE gene.A Idiopathic or hereditary hemochromatosis: There is a defect in the regulation of intestinal absorption of dietary iron, leading to net iron accumulation of 0.5 to 1.0 gyear. Hepcidin, produced by the liver, form a web of iron, metabolic control networks that are only recently become elucidated. Deposits sites - liver, pancreas, spleen, heart and endocrine glands Manifests typically after 20 gm of storage iron has accumulated.B Secondary or acquired hemochromatosis: Multiple blood transfusion. Ineffective erythropoiesis as in G thalassemia and myelodysplastic syndrome. Increased iron intake.The occurrence of hepatocellular carcinoma is a late complication of hemochromatosis - induced cirrhosis. K.F. Ring produced by the alloy of copper in the eye seen in Chalcosis - deposited in Descemets membrane of the cornea. 