<prompt> Which hypolipidemic drug acts primarily by decreasing VLDL -FibratesNicotinic acidStatinsCholestyramine  <response>: Ans. isai.e., FibratesRef: KDT 6he p. 614; Harrison 18the ch. 356Fibrates e.g. clofibrate activate lipoprotein lipase, therefore, enhance lipolysis of triglycerides in VLDL.Statins and nicotinic acid also decrease VLDL but it is not their main mechanism of action. 