<prompt> Treatment of multiple carboxylase deficiencyBiotinPyridoxineThiamineFolic acid  <response>: Pathogenesis of multiple carboxylase deficiency Deficiency of either holocarboxylase synthase or biotinidase impaires biotin metabolism.Biotin is a cofactor for various carboxylases in the body -Impaired metabolism of biotin results in multiple carboxylase deficiency.So, for the treatment of multiple carboxylase deficiency, biotin should be given. 