<prompt> Haloperidol toxicity can cause?Weight lossShort QTAkathasiaDiarrhoea  <response>: ANSWER: C AkathasiaREF: Kaplan 9rh ed p. 1050, Goodman Gillman 2008 edition page 304HALOPERIDOL TOXICITY:i. Cardiac depressant:QT prolongationTorsades de pointesWeight gain: littleSedation: very littleAnticholinergic side effects: dry mouth, constipation .paralytic ileus, difficulties in urinating, massive sweatingAdverse neurological syndromes: Extra pyramidal effects common to most antipsychotic- ref table belowNEUROLEPTIC INDUCED DISORDERS Acute dystoniaAkathisiaParkinsonismTardive DyskinesiaNeurolepticMalignantSyndrome EarlyIntermediateIntermediateLate tardiveAnyOWithin 7 days of therapy or doseWithin 3 monthsof therapy or doseWithin 3 monthsof therapy or dose3-6 months dose may unmask dyskinesiaAnytime during therapy dose or high potency drugsI15-20with typical neuroleptics, 5 with atypical20305 per year of therapy Le. 50 in 10 years0.520-30 mortalityMUnclear, dopamine hypofunction at basal gangliaD2 receptor blockage in mesocortical pathwayD2 receptor blockage at striatumD2 receptor blockage at striatumIdiosyncratic, Relative depletion of dopamine in CNSRFMale , young, mental retardation, ho ECT, dose elevationElderly,female, mental retardation, Iron deficiency, Affective disorders, dose elevationElderly, Females , dementia, underlying parkinsonism, AIDS, dose elevationElderly, female, ho ECT, substance abuse, iron deficiency, Mental retardation, Mood disorder, Organic brain damage, Anticholinergic Dose decreaseMale, young, dose elevationSSlow, irregular,continuouscontractions,oculogyricmovements oftongue, torticollis,trismus,abnormal posture, blephero spasmUncontrolledrestlessness,pacing,compulsive foot taping, rocking movement, adversity to stand still, rapid alternation of standing sittingR rigidityA akinesiamcT tremor atypical-coarse, not pill rolling, late RABBIT SYNDROME Lip perioral tremorsRapid, irregular, continuous or intermittent contractions, orofasciolingual orlimbtrunkal, by stress activity,Life threateningF feverE EncephalopathyV Vitals unstableE Elevated CPK,WBCR RigidityTAnticholinergics: Benzatropine Antihistaminics: DiphenhydramineReduce doseor changeantipsychotic.Propranololdoc, poortreatmentoutcomeAnticholinergics:BenzatropineAntihistaminics:Amantadine,DiphenhydramineReplace by atypical antipsychotic clozapine is best, lithium carbamazepine for psychosis, BZD: buspirone for dyskinesiaBromocriptine, lisuride, carbidopa- levodopa,dantrolene sodium, ECTO Onset, 1 incidence, M Mechanism, RF Risk factors, S Symptoms, TTreatment 