<prompt> Methicillin resistant staphylococci do not respond to b-lactam antibiotics because:They produce a b-lactamase which destroys methicillin and related drugsThey elaborate an amidase which destroys methicillin and related drugsThey have acquired penicillin binding protein which has low affinity for b-lactam antibioticsThey are less permeable to b-lactam antibiotics  <response>: Ref: KDT 6e p700 Resistance to most penicillins is due to elaboration of beta-lactamase. Methicillin is most resistant penicilling to b-lactamase. Staphylococcus aureus develops resistance to methicillins by acquisition of altered pencillin binding proteins. 