<prompt> Which of the following drugs has covalent interaction with its targetAspirinPenicillinNitric oxideBosentan  <response>: Aspirin is Acetylsalicylic acid conves to salicylic acid in the body, responsible for the action. It acts irreversibly by binding to cox enzyme through covalent- strong bonds ESSENTIALS OF MEDICAL PHARMACOLOGY;7TH EDITION; KD TRIPATHI;PAGE NO 195 