<prompt> Chronic Active Hepatitis is most reliably distinguished from chronic Persistant hepatitis by the presence -Extrahepatic manifestationSignificant titre of antismooth muscle antibodyCharacteristic liver histologyHepatitis B surface antigen  <response>: Ans. is c i.e., Characterstic liver histologyMinimal chronic hepatitis previously called chronic persistent hepatitisThe poal chronic inflammation is mild and is restricted to the paal triads without extension into the Liver lobule across the limiting plate.Chronic active hepatitis-4 characterized by continuing necrosis of Liver cells. The severe inflammation disrupts the limiting plate. 