<prompt> Ritchers transformation is associated with?CMLCLLAMLALL  <response>: Ans. is b i.e. CLL Richters syndrome RS, also known as Richters transformation, is a transformation which occurs in about 5-10 of B cell chronic lymphocytic leukemia CLL and hairy cell leukemia into a fast-growing diffuse large B cell lymphoma, a variety of non-Hodgkin lymphoma which is refractory to treatment and carries a bad prognosis. CLL has a tendency to transform into more aggressive lymphoid neoplams:-A. Prolymphocytic leukemia - Characterized by worsening of cytopenia, marked splenomagaly and appearance of prolymphocytes in the peripheral blood.B. Richiter syndrome - CLL is transformed into diffuse large B-cell lymphoma 