<prompt> Degradation of a substance takes place in which part of the cell:MitochondriaNucleusLysosomeER  <response>: Ans: c Lysosome Ref: Vasudevan, 4th ed,p. 17Degradation of a substance takes place in lysosomes. Phagosomes fuse with lysosomes to form phagolysosomes, inside which particles are digested.Lysosomal storage disease:DiseaseEnzyme deficiencyMajor accumulating metaboliteGlycogenosesType II Pompes diseaseLysosomal glucosidaseGlycogenSphingolipidoses GM 1GMl gangliosideGM 1 gangliosideGM 2Beta galactosidaseGM 2 gangliosideTay sachs diseaseHexosaminidase A Sulfatidoses Gaucher diseaseGlucocerebrosidaseGlucocerebrosideNiemann Pick diseaseSphingomyelinaseSphingomyelinMucopolysaccharidoses MPS 1 HurlerL-IduronidaseHeparan sulfate Dermatan sulfateMPS 11 HunterL- Iduronosulfate sulfataseHeparan sulfate Dermatan sulfate 