<prompt> DOC for acute organophosphate poisoning is:NeostigmineAtropinePilocarpineTubocurarine  <response>: Atropine It is highly effective in counteracting the muscarinic symptoms, but higher doses are required to antagonize the central effects. It does not reverse peripheral muscular paralysis which is a nicotinic action. All cases of anti-ChE carbamate or organophosphate poisoning must be promptly given atropine 2 mg i.v. repeated every 10 min till dryness of mouth or other signs of atropinization appear upto 200 mg has been administered in a day. Continued treatment with maintenance doses may be required for 1- 2 weeks. Reference: Essentials of Medical Pharmacology Eighth Edition KD TRIPATHI page no 122,123 