<prompt> A 40 years old female presented to OPD with this lesion in the breast. What is the most probable diagnosis?DCISLCISPeau-d-orangePagets disease of nipple  <response>: PAGETS DISEASE is a superficial manifestation of an underlying breast carcinoma 95 it presents as an eczema like condition of nipple and areola that persists despite treatment. Microscopically, Pagets disease is characterized by the presence of large, ovoid cells with abundant clear, pale staining cytoplasm in the Malpighian layer of epidermis. Treatment: mastectomy axillary staging or wide local excision of nipple and areola to achieve clear margins, axillary sampling and radiation therapy. PEAU-D-ORANGE 