<prompt> Which of the following liver enzymes is predominantly mitochondrial:SGOT ASTSGPT ALTGGTNucleotidase  <response>: A i.e. SGOT ASTGlutamate dehydrogenase GDH and aparate aminotransferase ASTor serum glutamate oxaloacetate transaminase SGOTQ mitochondrial isoenzyme, are liver enzymes predominantly present in mitochidrial matrix.AST or SGOT exists in genetically distinct 2 different forms which are named at their location: 1 Mitochondrial isoenzyme 80 is responsible for maximum AST activity of liver and ; 2 Cytosolic or cytoplasmic isoenzyme 20 is responsible for most of circulating AST activity.AST SCOT is found in maximum concentration in Hea. Mn She GOT Hea and then in liver, skeletal muscle and kidney. So elevated levels of mitochondrial AST or mitochondrial ASTTotal AST ratio is indicative of necrosis of cells containing AST and thus causing cellular leak eg hea cell necrosis in MI or liver cell necrosis in chronic liver disease.SCOT AST and SGPT ALT both are found in most tissues but their relative amounts vary. Hea muscles are richer in SGOT whereas liver is richer in SGPTQ. 