<prompt> In a pathological examination of renal biopsy specimen, focal change is diagnosed when the changes are limited to:10 of glomeruli30 of glomeruli50 of glomeru25 of glomeruli  <response>: Renal biopsy specimen assessment: Each region of a renal biopsy is assessed. 50 involvement is considered focal, and 50 is diffuse. Injury in each glomerular tuft can be segmental or global. Glomeruli having proliferative characteristics. When cells in the capillary tuft proliferate, it is called endocapillary, and if extends into Bowmans space, it is called extracapillary. Ref: Harrison-18, P-2339. 