<prompt> Late onset of puberty in the male is defined asPuberty onset after 16 yearsPuberty onset after 17 yearsPuberty onset after 18 yearsPuberty onset after 21 years  <response>: The diagnosis of delayed puberty is made when signs of sexual development, such as an increase in the volume of the testis are not evident even by the age of 14years in boys and breast budding by 13 years in Girls.Some important causes of delayed pubertyHypothyroidismHyperprolactinemiaNoonan syndromeKlinefelter syndrome 