<prompt> Which of the following is most appropriate treatment of a patient of tuberculosis in which mycobacterium is resistant to both isoniazid and rifampicin?6 drugs for 4 months and 4 drugs for 12 months6 drugs for 6 months and 4 drugs for 18 months6 drugs for 6 months and 4 drugs for 4 months5 drugs for 2 months; 4 drugs for one month and 3 drugs for 5 months  <response>: Types of resistance in TB: Monodrug Resistance: Resistance against any first line oral drug except Rifampicin H, Z or E. Polydrug Resistance: Resistance against more than one out of first line oral drugs except Rifampicin. Multidrug Resistance MDR-TB: Resistance to Isoniazid H as well as Rifampicin R. Rifampicin Resistance RR: Resistance to Rifampicin but sensitive to Isoniazid. Extensive drug ResistanceXDR-TB: Resistance to H R minimum one of the fluoroquinolone Levoflox, Moxiflox, Gatiflox minimum one of the injectable drug Amikacim, Capreomycin, Kanamycin. Treatment consists of 2 phases: Intensive Phase IP and Continuation Phase CP Monodrug Resistance IP : 3 months CP: 6 months MDR IP : 6 drugs for 6 months CP: 4 drugs for 18 months XDR IP : 7 drugs for 6 months CP: 6 drugs for 18 months In MDR and XDR TB therapy is decided by Drug sensitivity testing. In the question the case given is of MDR TB. 