<prompt> The commonest cause of primary amenorrhea with ambiguous genitalia in a female with 46XX chromosome21 hydroxylase def.17 hydroxylase def.11 hydroxylase def.Desmolase hydrolase def.  <response>: Ans. is a i.e. 21-hydroxylase deficiency Primary amenorrhoea with virilization ambiguous genitalia in females is seen in21 hydroxylase def.11 hydroxylase def17-hydroxylase def. does not cause virilization. It causes in females- Primary amenorrhoea and failure of development of secondary sexual characteristics.21-hydroxylase and 11-hydroxylase deficiencies are common; the former accounts for 90-95 of the cases of congenital adrenal hyperplasia, and the latter accounts for all but 1 of the remaining cases.Also know thisCongenital adrenal hyperplasiaIs commonly caused by there 4 enzyme deficiencies.21 hydroxylase def. Complete21 hydroxylase def. Partial11 hydroxylase def.17 hydroxylase def.21 hydroxylase def. Complete Salt loosing virilizingHypotensionVirilization Precocious puberty in males21 hydroxylase def. partial Simple virilizingNormal B.P.Virilization Precocious puberty in males11 hvdroxvlase def.HypertensionVirilization Precocious puberty in males17 hvdroxvlase def. hypertensionHypertensionNo virilization in femalesPrimary amenorrhoea and failure of development of sec. sec. characteristics in femalesMale hermaphrodites 