<prompt> False statement regarding Hodgkins disease is: September 2009CNS is the commonest site of involvementMediatinal involvement is common in nodulosclerosis typeCharacteristic cell is a Reed-Sternberg cellIncrease in eosinophils and plasma cells  <response>: Ans. A: CNS is the commonest site of involvement The most common symptom of Hodgkins is the painless enlargement of one or more lymph nodes. The nodes may also feel rubbery and swollen when examined. The nodes of the neck and shoulders cervical and supraclavicular are most frequently involved 80-90 of the time, on average. The lymph nodes of the chest are often affected Central nervous system CNS involvement by Hodgkin lymphoma HL is rare. 