<prompt> Which of the following drugs have least affinity for CYP3A4?OmeprazoleLansoprazoleEsomeprazoleRabeprazole  <response>: Ans. D RabeprazoleRef: Katzung 13th1060, KDT 8the p701Proton pump inhibitors are metabolized by CYP3A4 and CYP2C19. They are also inhibitors of these enzymes. Rabeprazole and pantoprazole has less affinity for these enzymes. 