<prompt> Dermatomyositis associated with Anti-Mi2 antibodies shows strong association withHeliotrope rashMechanic handsButterfly rashDiscoid rash  <response>: Dermatomyositis is a systemic autoimmune disease that typically presents with proximal muscle weakness and skin changes. Ceain autoantibodies tend to be associated with specific clinical features:Anti-Mi2 antibodies directed against a helicase implicated in nucleosome remodeling show a strong association with prominent Gottron papules and heliotrope rash Anti-Jo1 antibodies directed against the enzyme histidyl t-RNA synthetase are associated with interstitial lung disease, nonerosive ahritis, and a skin rash described as mechanics hands.Anti-P155P140 antibodies directed against several transcriptional regulators are associated with paraneoplastic and juvenile cases of dermatomyositis.Butterfly and Discoid rash are seen in SLERef: Robbins and Cotran Pathologic Basis of Disease; 9th edition; Chapter 27; Peripheral Nerves and Skeletal Muscles; Page no: 1238 