<prompt> About lidocaine all are true, exceptDose need to altered in renal failureLoading dose before infusionIt is little effected by heat pHProlongs refractory period  <response>: Local anaesthetics are poorly water-soluble and this limits their renal excretion to less than 5. For treating ventricular arrhythmias initial loading dose is to be followed by infusion. The amides are so stable that they are not effected even by autoclaving. Effective refractory period of cardiac tissue is prolonged by local anaesthetics. 