<prompt> All of the following drug act on ionic channels EXCEPT:ValproateInsulinGlibenclamideDiazepam  <response>: ANSWER: B InsulinREF: KDT 6th edition various pages 394, 256, 266For valproate mechanisms of action see previous questionBinding of insulin to a subunit if insulin receptor induces the aggregation and internalization of the receptor along with the bound insulin molecule. This activates tyrosine kinase activity if 3 subunit.Sulfonylureas Glibenclamide provoke a brisk release if insulin from pancreas. They act on the so called sulfonylurea receptors on the pancreatic b cells membrane- causes depolarization by reducing conductance of ATP sensitive K channels. This enhances Ca2 influx - degranulation.BZD Diazepam act by enhancing pre synapticpost synaptic inhibition through a specific BZD receptor which is an integral part of the GABAA receptor - Cl- channel complex. 