<prompt> Etanercept used in rheumatoid arthritis acts byInhibition of COX2 and COX-3Inhibition of TNFaPotent immunosuppresent actionAuto immunologically mediated action  <response>: i.e. Inhibition of TNFa: 203-205-KDT 6th 803-CMDT-l1Soluble TNF-aR etanercept and IL-1 receptor antagonist act to inhibit the activity of pathogenic cytokines in rheumatoid arthritis i.e. TNF-a and IL-1TNFa inhibitors - Etanercept, Infliximab, Adalimumab, golimumab, and certolizumab pegol - A pro inflammatory cytokines - are fulfilling the aim of target therapy for rheumatoid arthritisAbatacept is a costimulation - modulator that inhibits the activation of T-cells 629-Katzung 11th 