<prompt> A young child diagnosed with chronic osteomyelitis of the tibia. Doctor begun with sensitive antibiotics. Out of the listed parameters, which is best to monitor the response of antibiotic after 6 days?ESRC-reactive protein CRPDifferential WBC countTotal WBC count  <response>: The C-reactive protein CRP values are usually elevated within 12-24 hours reaches its peak after the onset of symptoms. It returns to normal within 7-8 days after adequate treatment staed, So it is best to monitor the antibiotic response. ESR returns to normal approximately 3 weeks after treatment is begun Both reactants CRPESR offer more information if simultaneously elevated. WBC count rises and the haemoglobin concentration may be diminished. In extremely young and old age , these tests are less reliable and may show values within the range of normal. 