<prompt> Sterility is caused by -Vinca alkaloidsAlkylating agentsAntimetabolitesActinomycin D  <response>: Ans. is b i.e., Alkylatings agents Alkylating agents may contribute to sterility by the following effects : Azoospermia in males Amenorrhea and ovarian atrophy in females Specific toxicity of impoant alkylating agents. o Cyclophosphamide --- Cystitis, alopecia, SIADH o Ifosfamide --- Cystitis, SIADH, neurotoxicity o Cisplatin --- Nephrotoxicity, peripheral neuropathy, ototoxicity, vomiting. o Busulfan --- Adrenal insufficiency, hyperpigmentation,pumonaryfibrosis. o Procarbazine --- Disulfiram like reaction, secondary leukemias, CNS effects. 