<prompt> Which of the following is true about nephrogenic diabetes insipidusRenal tubule is unresponsive to ADHThere is central decrease in secretion of ADHSerum sodium is lowUrine osmolality is increased after administration of ADH  <response>: Answer is A Renal tubule is unresponsive to ADH: Nephrogenic Diabetes Insipidus is charachterized by resistance of action of ADH on Renal tubules or unresponsiveness of renal tubules to the action of ADH or Renal Hyposensitivity to action of ADH. Serum sodium is typically high increased, urine osmolality is low and fails to increase after exogenous administration of ADH vasopression. 