<prompt> 46-year-old woman with prominent splenomegaly presents with a 3-month history of malaise, easy fatigability, weakness, weight loss, and anorexia. A complete blood count and differential demonstrates a white blood cell count of 250,000mm3 normal 3,000 to 10,000mm3 with a predominance of myelocytes, metamyelocytes, band cells, and segmented neutrophils. Cytogenetic analysis is most likely to reveal which of the following translocationst8;14t9;22t11;22t14;18  <response>: The translocation t9;22 is the characteristic translocation associated with chronic myelogenous leukemia, forming the so-called Philadelphia chromosome. The resultant fusion protein, p210, has increased tyrosine kinase activity that contributes to the uncontrolled proliferation in this form of leukemia. -The translocation t14;18 is seen in follicular lymphoma -t8;14 in Burkitt lymphoma -t15;17 in the M3 variant of acute promyelocytic leukemia AML -t11;22 in Ewing sarcoma, a relatively uncommon tumor of bone Philadelphia chromosome-In ALL The resultant fusion protein, p190, has increased tyrosine kinase activity thatcontributes to the uncontrolled proliferation acute lymphoblastic leukemia and associated with BAD prognosis. 