<prompt> Which type diabetes is HLA associated?Type I diabetesType II diabetesMalnutrition related type diseasePregnancy related type diabetes  <response>: Type 1 DM results from the interactions of genetic, environmental, and immunologic factors which ultimately leads to the destruction of the pancreatic beta cells and insulin deficiency. Type 1 diabetes is HLA associated. Gene for type 1 DM is located in the HLA region on chromosome 6. Polymorphisms in the HLA complex account for 40-50 of risk of developing type 1 DM. Most individuals with type 1 DM have the HLA DR3 andor DR4 haplotype. Haplotypes DQA10301, DQB10302, and DQB10201 are strongly associated with type 1. Haplotype DQA10102, DQB10602 appears to provide protection from type 1 DM. Ref: Harrisons Principle of Internal Medicine, 18th Edition, Page 2973 