<prompt> A hypeensive patient on medication with beta blocker develops severe bradycardia on taking medicines. Which of the following is least likely to be the responsible agent?MetoprololNadololPindololAtenolol  <response>: Pindolol has intrinsic sympathomimetic acitivity and therefore has lesser risk of causing bradycardia Beta-Blockers with Intrinsic Sympathomimetic Activity ISA Preferred in the patients prone to develop severe bradycardia with b blocker therapy. However, these drugs are less useful in angina because of stimulation of hea by b1 receptors. The drugs can be remembered as COntain - Celiprolol, Oxprenolol Paial - Pindolol, Penbutolol Agonistic - Alprenolol Activity -Acebutolol 