<prompt> Which of the following statement is not true about NSAIDsAcetylsalicylic acid is an Irreversible inhibitors of Cox enzyme acetylsalicylic acid is an Irreversible inhibitors of Cox enzymeAcetylsalicylic acid reduces in Vivo synthesis of prostaglandinsIts clearance is independent of Plasma concentrationAntiplatelet effect of low dose aspirin is related to pre systemic Cox inhibition  <response>: Acetylsalicylic acid asprin is an Irreversible inhibition of COX enzyme. IT results in inhibition of prostaglandin and TX synthesis at low doses for 40 to 325 milligrams it exes antiplatelet action. this drug shows saturation kinetics at high doses that is kinetics changes from first order to zero order. therefore at high doses amount of drug exeed will be constant that means clearance il is not constant. Refer kDT 6e p185 