<prompt> All are the features of Pagets disease except-Defect in osteoclastsCommon in femaleCan cause deafnessCan cause osteosarcoma  <response>: Pagets disease is slightly more common in males and is seen after 40years of age. Paget;s Disease Osteitis Deformans Excess of bone destruction organized bone formation and repair. The 2 nd most common bone disorder in the U.S. The etiology is unknown Usually affects the axial skeleton, veebrae and skull, although the pelvis, tibia, femur are the other common sites of disease. Most persons are asymptomatic diagnosis is incidental. Vascularity is increased in affected poions of the skeleton. Lesions may occur in one or more bones, does not spread from bone to bone. Deformities bony enlargement often occur. Bowing of the limbs spinal curvature in persons with advanced disease. Bone pain- is the most common symptom. Is is usually worse with ambulation or activity but may also occur at rest. Involved bones may feel spongy warm because of increased vascularity . Skull pain is usually accompanied with headache, warmth, tenderness enlargement of the head. Radiograph reveals radiolucent areas in the bone, typical of increased bone resorption. Deformities fractures may also be present. Goals of the treatment- to relieve pain prevent fracture deformities. Pharmacologic agents are used to suppress osteoclastic activity. Bisphosphonates calcitonin are effective agents to decrease bone pain bone warmth also relieve neural decompression, joint pain lytic lesions. Use of analgesics NSAIDs. Assistive devices, including cane, walker . Ref: Turek 6the p.274-275 