<prompt> Alpha fetoprotein synthesized fromYolk sacPlacentaFoetal brainFoetal kidney  <response>: Yolk sac 107-D AFP - is a oncofetal protein it is produced by yolksac and fetal liver Highest level of AFT in fetal serum and amniotic fluid reached around 13 weeks and thereafter it decreases Maternal serum level reaches a peak around 32 weeks Test is done between 15-18 weeksMSAFP level is elevated ina Wrong gestational ageb Open neural tube defectsc Multiple pregnancyd IUCDe Anterior abdominal wall defectsf Renal anomaliesMSAFP level is lowin Trisomies Downs syndrome gestational trophoblastic disease Triple test - includes MSAFP, hCG and UE3 Unconjugated oestriol 