<prompt> In a patient with mild hemophilia levels of clotting factor antihemophilic factor would be above51030Any of the above  <response>: Ans. a 5 Ref. Nelson paediatrics 18th ed., p. 2068HEMOPHILIA Life-threatening hemorrhages require replacement therapy to achieve normal plasma level 100 IUdL, or 100. Patients with mild hemophilia who have factor VIII or factor IX levels of 5 IUdL usually do not have spontaneous hemorrhages. These individuals may experience prolonged bleeding after dental work, surgery, or injuries. The hemostatic level for factor VIII is 30-40 pL, and for factor IX, it is 25-30. The lower limit of levels for factors VIII and IX in normal individuals is approximately-50. Even in patients with severe hemophilia, only 90 have evidence of bleeding by 1 yr of age. Although bleeding may occur in any area of the body, the hallmark of hemophilia is hemarthrosis. PTPTTMechanism and commentsHemophilia A or B Increased X-linked recessive inheritance, Intrinsic pathway coagulation defect. A: deficiency of factor VIII -PTT. And B; deficiency of factor IX -PTT. Macrohemorrhage in hemophilia --hemarthroses bleeding into joints, easy bruising, PTT. Treatment: recombinant factor VIII in hemophilia A.Vitamin K deficiencyIncreasedIncreasedGeneral coagulation defect. Bleeding time normal, synthesis of factors II, VII, IX, X, protein C, protein S 