<prompt> In Beta thalassemia, the most common gene mutation isIntron 1 inversionIntron 22619 bp deletion3.7 bp deletion  <response>: Ans. is a i.e., Intron 1 inversion Thalassemias are autosomal recessive disorder The most common mutation causing 13 thalassemias is introninversion Also know: Synthesis of alpha chain is controlled by 2 gene clusters on - Chromosome 16 Synthesis of beta chain is controlled by 2 gene clusters on - Chromosome 11 Thalassemia mutations in India Multations Frequency IVS1-5 G --C 48 619 bp defection 18 IVS-1 G T 9 FR4142TCTT 9 FR89 G 5 Codonl5 G -- A 6 Others 100 