<prompt> Loading drug of dose primarily depends onVolume of distributionClearanceRate of administrationHalf life  <response>: Loading dose; This is a single or few quickly repeated doses given in the beginning to attain target concentration rapidly.Loading dose Target Cp V FCp - concentration, V - volume of distribution, F - oral bioavailabilityThus, the loading dose is governed only by V and not by Clearance or t12 