<prompt> Initial mechanism of action of intra-tympanic gentamicin microwick catheter inseed into inner ear in treatment of Meniers diseaseDamage outer hair cellBinds to hair cell Na-K ATPase channelActs on melanoreceptors of outer hair cellBind to Mg channel  <response>: Ans. c. Acts on melanoreceptors of outer hair cell Intra-tympanic Gentamicin is used in Meniers Disease, it is Predominantly vestibulotoxic, and acts by destroying the dark cells melanoreceptors of the secretary epithelium, thus decreasing the endolymph production Intra-tympanic Gentamicin in Meniers Disease Mechanism of Action: Predominantly vestibulotoxic, and acts by destroying the dark cells melanoreceptors of the secretary epithelium,thus decreasing the endolymph production Gentamicin destroys the endolymph secreting dark cells before destroying the sensory vestibular epithelium This treatment has high efficacy in controlling the veigo upto 90. Regarding Gentamicin mechanism: The main alternative to the mechanism being destruction of dark cells is the hypothesis that there is a paial damage to the vestibular hair cells. Recent studies in animals suggest that the type-I hair cells are the most sensitive, and the type-II hair cells are more resiliant. 