<prompt> White centered retinal haemmorrhage is seen inSABELeukaemiaDiabetes mellitusAll of the above  <response>: D All of the above White centered superficial retinal hemorrhages Roths Spots or Haemorrhagic cotton-wool spot: First described by Roths in 1872, thought to be pathognomonic for subacute bacterial endocarditis. Etiology as per Roth Suggestion: Focal abscess from bacterial emboli lead to erosion of the capillary endothelium and resultant retinal haemorrhage which is then filled with RBC and WBC. Other possibilities are: ; Coagulated albuminous material; Necrotic nerve structures. ; Cytoid bodies ; Focal nerve fibre layer infarcts ; Antigen-antibody complexes ; Fibrin and platelet deposits, Central clearing of previous hemorrhageROTHS SPOTS DIFFERENTIAL DIAGNOSISInfectionsNon-Infections Bacterial endocarditisLeukemias Septicemia bacterial or fungalAnemias HIV retinitisMultiple myelomas CMV retinitisDiabetic retinopathy ToxoplasmosisHypertensive retinopathy RetinochoroditisCRVOBRVO TB retinal vasculitisSarcoidosis Vasculitis Sypilitic retinitisRadiation retinopathy Shakon Bay syndrome Viral pneumoniaPurtschers retinopathy Candida albicansLupus retinopathy; Retinal phlebitis 