<prompt> All are true about histo-immunological type of breast cancer EXCEPT:Molecular classification is based on gene expression profilingMost common type is Luminal ABest Prognosis is Luminal BWorst prognosis is triple negative breast cancer  <response>: Molecular classification of breast Ca is based on gene expression profiling. Molecular classification: Luminal A: ER PR ve, double positive HER - 2 - neu - ve Ki67 lowMost common type, best prognosis. Luminal B: two subtypes- 1. Luminal B HER ER, PR - positive Her - 2 - neu positive triple positive and Ki67 lowhigh 2. Luminal B HER- ER, PR - positive Her - 2 - neu negative and Ki67 high Intermediate prognosis Basal cell type: triple negative ER, PR Her-2-neu -ve Ki67 high In BRCA 1 mutation most aggressive and Poorer prognosis because there are fewer targeted medicines available Her-2 type: Her-2-neu veER, PR -ve aggressive and poor prognosis Normal like breast cancer- same like luminal A but prognosis poorer than luminal A Most common: luminal A Best prognosis: Luminal A Worst prognosis: Triple negative breast cancer 