<prompt> The karyotope in testicular feminising syndrome is ?XXXYXXYXXXY  <response>: Testicular feminising syndrome or androgen insensitivity syndrome is an X linked disorder of androgen action. It is characterised by resistance to androgens. Its karyotype is 46,XY. Pathology Affected individuals are genotypically male with a 46XY karyotype but with a female phenotype Genetics Thought to carry an X linked recessive inheritance 3 where multiple mutations in the androgen receptor AR gene has been localized to the long arm of the X chromosome i.e. Xq11-13. Reference: Ghai TB of pediatrics 8th edition,pg 538 table 17.32 