<prompt> Brain edema is associated withIncrease in ECF volumeIncrease brain water contentIncrease volume in interstitial spaceNone of the above  <response>: A Increase in ECF volume Vasogenic edema occurs when the integrity of the normal blood-brain barrier is disrupted. With increased vascular permeability, fluid shifts from the vascular compartment into intercellular spaces of the brain ECF compartment. Vasogenic edema can be either localized-because of abnormal permeability of vessels adjacent to inflammation or tumors-or generalized. Cytotoxic edema implies an increase in intracellular fluid secondary to neuronal, glial, or endothelial cell membrane injury, as might be encountered in an individual with a generalized hypoxicischemic insult or with exposure to some toxins. 