<prompt> The granuloma is characterized byFocal accumulation of activated macrophagesCollection of neutrophilsNewly formed vesselsCollection of eosinophils  <response>: Granulomatous inflammation is a distinctive pattern of chronic inflammation characterized by aggregates of activated macrophages with scattered lymphocytes granuloma:-is an aggregation of macrophages surrounded by a collar of mononuclear cells principally lymphocytes Macrophages may get activated to form epithelioid cells Some of the cells may fuse together to form a bigger cell called a giant cell Older granulomas may have a rim of fibroblasts and connective tissue Common conditions resulting in granuloma formation with impoant features Tuberculosis Sarcoidosis Non-caseating granuloma Brucellosis Cat scratch disease Stellate shaped or round granuloma Syphilis Gumma Leprosy Inflammatory bowel disease ref pathology robbins 9th ed page 56 