<prompt> Which of the following plasminogen activator fibrinolytic can be given as bolus dose in patients with acute myocardial infarction:UrokinaseAlteplaseReteplaseNone  <response>: Essentials of medical pharmacology, seventh edition, page no 627 Answer is option3, reteplase It is a modified form of -PA that is longer acting, but somewhat less specific for fibrin bound plasminogen. The longer duration of action enables bolus dose administration, 10mg over 10 minutes repeated after 30minutes. 