<prompt> Which of the following genes involved in the synthesis of immunoglobulins are linked on a single chromosome?C gene for gamma chain and C gene for alpha chainC gene for gamma chain and C gene for kappa chainV gene for kappa chain and C gene for the epsilon chainV gene for lambda chain and C gene for kappa chain  <response>: The genes for the synthesis of the entire heavy chain are present on human chromosome 14. Of the options given above, the only genes that are present on one chromosome are for the C constant regions of the heavy chains. Remember, the heavy chains determine the identity of the immunoglobulin isotypes: IgG, IgM, IgA, IgD, and IgE. The C gene for the gamma heavy chain is on chromosome 14 and the C gene for the kappa light chain gene is on chromosome 2. The V gene for the kappa light chain is on chromosome 2. The C gene for the epsilon heavy chain is on chromosome 14. The V gene for the lambda light chain gene is on chromosome 22. The C gene for the kappa light chain gene is on chromosome 2. Ref: Levinson W. 2012. Chapter 58. Cellular Basis of the Immune Response. In W. Levinson Ed, Review of Medical Microbiology Immunology, 12e. 