<prompt> Lischs nodules are seen in?SLESystemic sclerosisNF-1Mixed connective tissue disorder  <response>: Ans is c i.e. NF-1 o A Lisch nodule is a pigmented hamartomatous nodular aggregate of dendiritic melanocytes affecting the iris. They appear as clear, yellow-brown, oval to round, dome-shaped papules that project from the surface of the iris. They are detected by slit lamp examination . These nodules typically do not affect vision, but are very useful in diagnosis.NF-1 is diagnosed if two of following sevens are present:-1 Six or more cafe-au-lait macules : 5mm in prepubertal age and 15 mm in postpubertal age.2 Axillary or inguinal freckling.3 Two or more Lisch nodules hamartomas on iris.4 Two or more neurofibroma or one plexiform neurofibroma.5 A distinctive osseous lesion : Sphenoid dysplasia or cortical thinning of long bones.6 Optic glioma.7 A first degree relative with NF-1. 