<prompt> Most common genetic mutation associated with Hirschsprung disease is:RET geneEND3 geneATP 7AEDNRB gene  <response>: Genetic studies have identified mutations in different genes contributing to the development of Hirschsprung disease. The more common mutations are RETgene 7-35 of sporadic cases, EDNRB gene 7 END3 gene 5 Ref: Seminars in Pediatric Surgery 2008 17, 266-275. 