<prompt> Intrahepatic perisinusoidal portal hypertension is classically caused by?Alcoholic hepatitisSchistosomiasisBudd-Chiari syndromeAll of the above  <response>: Ans. b Schistosomiasis Ref: Harrisons Internal medicine 18thCh. 308, 219SCHISTOSOMIASIS: Pipe-stem fibrosis in presinusoidal space with portal hypertension.ALCOHOLIC HEPATITIS : Accumulation of fat occurs initially in perevenular fibrosis, giant mitochondria etc.BUDD - CHIARI SYNDROME: Form of Acute congestive hepatomegaly due to occlusion of hepatic veins or inferior vena cava with grossly enlarged tender liver and severe intractable as- cites.Causes of portal hypertensionl. Prehepatic Portal vein thrombosis - independent of cause, splenic vein thrombosis, cavernous transformation of the portal vein, splenic arteriovenous fistula, idiopathic tropical splenomegaly2.1ntraliepatica presinusoidal Schistosomiasis, chronic viral hepatitis H3V, HCV. cirrhosis biharis ptimaria. myeloproliferative diseases, focal nodular hyperplasia, idiopathic portal hypertension, sarcoidosis, mberculosis, Wilsons disease, hemochromatosis, amyloidosis, remaining storing diseases, polycystic liver disease, infiltration of liver hilus - independent of cause, benign and malignant neoplasmsb sinusoidal Liver cirrhosis - independent of etiology, acute viral and alcoholic hepatitis, acute fatty liver of pregnancyc postsinusoidal Venous-occlusion disease, alcoholic hyaline sclerosis of central veins3.Extrahepatic Hepatic veins thrombosis Budd- Chiari disease, inflammatory neoplastic infiltration cavenng hepatic veins, eaval inferior occlusion thrombosis, neoplasms, cardiac diseases: chrome right ventricular failure, chronic constrictive pericarditis, tncuspid insufficiency 