<prompt> Pethidine should not be given with -ReserpinePropranololAtenololMAO inhibitors  <response>: Ans. is d i.e., MAO inhibitors o MAO inhibitors inhibit hydrolysis but not detmethylation -- more norpethidine is produced. Hydrolysis Mepridinic acid major metabolic Pethidine Dernekiation Norpethidine minor metabolite o MAO inhibitors selectively inhibit its hydrolysis without effecting demethylation -4 Accumulation of norpethidine -- Excitement. 