<prompt> True about BCR- ABL traits are all except:P190 has an indolent courseP190 is a bad prognostic factorP230 is positive in chronic neutrophilc leukemiaP230 has an indolent course  <response>: Ans: a P190 has an indolent courseRobbins Pathology, 9th editionChronic myeloid leukemia CML is characterized by the Philadelphia Ph chromosome, which results from the t9;22q34;q11 balanced reciprocal translocation.Three breakpoint cluster regions have been characterized to date: major M-BCR, minor m-BCR and micro mu-BCR.The smallest of the fusion proteins, p190BCR-ABL m-BCR breakpoint is principally associated with Ph-positive ALL.P190 transcript is associated with a poor prognosis.CML due to a p90-type of BCR-ABL gene have a prominent monocytic component, resembling CMML.CML resulting from a p230 BCR-ABL gene mu-bcr breakpoint is associated with the CNL variant andor with marked thrombocytosis.Patients with p230 positive CML-N have indolent course, probably as a result of low p230 mRNA and protein levels.CML - More than 90 have p210 fusion protein. 