<prompt> A 2 month old baby with acute viral hepatitis like illness slips into encephalopathy after 48 hours. The mother is a known hepatitis B carrier. Mothers hepatitis B virus serological profile is most likely to be:HbsAg positive onlyHbsAg and HbeAg positiveHbsAg and Hbe antibody positiveHBVDNA positive  <response>: HBeAg-positive women in third trimester frequently transmit infection to the fetus 80-90 in the absence of immunoprophylaxis, whereas those who are negative rarely infect the fetus. After delivery both HBIG and Hepatitis B vaccine is given to the neonate. Ref: Kliegman, Behrman, Jenson, Stanton 2008, Chapter 355, Viral Hepatitis, In the book, NELSON TEXTBOOK OF PEDIATRICS, Volume 2, 18th Edition, New Delhi, Page 1683. 