<prompt> True about wilsons diseaseIncrease in urinary copper and increased serum ceruloplasmin and copperIncreased serum ceruloplasmin levels with increased urinary copperElevated hepatic copper level and increased serum ceruloplasmin levelsIncreased in urinary copper and decreased serum ceruloplasmin  <response>: Diagnosis of Wilson disease Diagnosis includes the demonstration of a reduced ceruloplasmin level, increased urinary excretion of copper, the presence of Kayser-Fleischer rings in the cornea of the eyes, and an elevated hepatic copper level, in the appropriate clinical setting.CeruloplasminSerum glycoprotein that contains six copper atoms.Copper incorporation into ceruloplasmin is impared in Wilsons disease.95 of homozygotes have levels 20mgdL rarely are levels 30 mgdL.May also be low in other hypoproteinemic statesMay be low in 20 of asymptomatic heterozygotesSerum free copper unbound copperGreater than 25 mg in symptomatic pts normal 10Slit lamp detection of Kayser Fleischer Rings24 hour urinary copper excretionMay exceed 100 mg24 h-use metal free containerFalse with sign. Proteinuria ceruloplasmin lossLiver biopsy 250 gg copper dry weight in homozygotes normal 50.Cholestatic diseases PBCPSC may have elevated hepatic copper dry weight. 