<prompt> Characteristics of SIRS include all of the following except:LeukocytosisThrombocytopeniaTachycardiaOral temperature more than 38degC  <response>: SIRS Systemic Inflammatory Response Syndrome- Mediators of SIRS IL - I IL - 6 TNF - a- It is bodys inflammatory response to infectious or non-infectious insult - Parameters of SIRS Temperature 38deg C Or 36deg C HR 90 min Respiratory rate 20min WBC count 12000ml or 4000ml or 10 immature cells in the peripheralblood Note: 2 of 4 should be present Sepsis - SIRS Established focus of infectionSevere sepsis - Sepsis with organ dysfunction of hypoperfusionSeptic shock - Sever sepsis not responding to IV Fluids According to 2016 Criteria- Sepsis - Suspected or Documented infection Acute increase in ? 2 SOFA points- Septic Shock - Suspected or documented infection Vasopressor therapy needed tomaintain MAP ? 65 mmHg of serum lactate 2.o mmolL despite of adequate fluidresuscitation 