<prompt> Cryoprecipitate cannot be used in?Von-Wilbrand diseasHemophilia AHemophilia BDIC  <response>: Ans. is c i.e., Hemophilia B Hemophilia B Christmas disease is due to deficiency of factor IX. Cryoprecipitate does not contain factor IX. Therefore cannot be used. Fresh frozen plasma or recombinant factor IX is used for treatment. Cryoprecipitate contains fibrinogen, factor VIIIc and vWF, and factor XIII. It is most commonly used in hypofibrinogenemia e.g. in DIC. It can also be used in hemophilia A and von-Willebrand disease but recombinant factor and desmopressin are preferred in these conditions. 