<prompt> Orphan Annie eye nuclei is characteristic histologic feature of which of the following thyroid malignancy ?Papillary carcinoma of thyroidMedullary carcinoma of thyroidAnaplastic carcinoma of thyroidFollicular carcinoma of thyroid  <response>: Orphan Annie nuclei is a characteristic intranuclear inclusion seen mainly in papillary carcinoma of thyroid. Ultrastructurally they are seen as membrane bound spheroidal masses of cytoplasm intruding into the nuclei. Intranuclear inclusions are less commonly seen in hyalinizing trabecular adenomas, medullary carcinoma, huhle cell carcinoma as well as anaplastic carcinoma. 