<prompt> The following Thiazide diuretic is active if the GFR is 30-40 mm HgMetolazoneBenzthiazideChlorothiazideChlohalidone  <response>: Although most thiazide diuretics lose their effectiveness in renal failure, metolazone remains active even when the glomerular filtration rate GFR is below 30-40 mLmin moderate renal failure. This gives it a considerable advantage over other thiazide diuretics, since renal and hea failure often coexist and contribute to fluid retentionRefer: K. D. Tripathi;s Essentials of Medical Pharmacology, 7th edition, pg no: 583 