<prompt> During development, all the antigens of self are introduced to thymic cells in-order to be removed to prevent autoimmunity. Which of the following genes is involved in the process?NOTCH1AIRERB geneCPK gene  <response>: Ans. b AIRERef: R 9p 213The process in the questions refers to Central tolerance, where the self reacting T cells are presented to the thymus to prevent autoimmunity. A protein called AIRE autoimmune regulator stimulates expression of few peripheral tissue-restricted self antigens in the thymus. This causes deletion of immature T cells specific for these antigens and so is able to prevent autoimmunity. 