<prompt> The antidote of paracetamol poisoningFlumazenilNalexoneN-acetyl cysteineSodium bicarbonate  <response>: Overdosage of PCM is treated with N-acetyl cysteine used orally within 16 hours after ingestion at a loading dose of 140 mg Kg diluted to 5 solution orally.Followed by 70 mg Kg q 4hr for another 2 days PCM is the most common analgesic, antipyretic used in children Paracetamol produces a highly reactive toxic minor metabolites -N-acetyl benzoquinone amine. Normally this metabolite is detoxified by conjugation with glutathione - when a very large dose of paracetamol is taken glucuronidation capacity is saturated and this metabolite is not detoxified Hepatic glutathione is depleted Excess metabolite N acetyl benzoquinone binds to the protein in liver cells and renal tubules Centrilobular hepatic necrosis This single most important laboratory test in a patient who present after acetaminophen is the acetaminophen level in the serum. 