<prompt> In metabolic acidosis which of the following changes are seen?Increased K excretionDecreased K excretionIncreased Na excretionIncreased Na reabsorption  <response>: K secretion into the renal tubules when the H secretion is increased intracellular Buffering of H. Thus in metabolic acidosis, there is decreased K excretion. Factors afffecting K distribution between ECF and ICF concentration Shift Of K into the cell - Decrease in ECF K Shift Of K out of the Cell - Increase in ECF K Insulin Insulin deficiencyDM Aldosterone Aldosterone deficiency Addison;s disease Metabolic alkalosis Hypeonicity e.g., Hyperglycemia Diarrhoea Beta Blockers Cell lysis Eg., Intravascular hemolysis, tumor lysis syndrome, rhabdomyolysis Strenous excercise Ref: Guyton and Hall 13th edition Pgno: 387 