<prompt> A 40-year-old woman presents with a long history of vague upper abdominal pain and frequent indigestion with abdominal tenderness. Serum bilirubin is elevated 4.2 mgdL. There is a mild increase in serum AST and ALT 62 and 57 UL, respectively and a moderate increase in alkaline phosphatase 325 UL. Markers for viral hepatitis are negative. Abdominal ultrasound examination shows echogenic stone-like material within the gallbladder and thickening of the gallbladder wall. An intrahepatic mass is also visualized adjacent to the gallbladder. A cholecystectomy is performed. Histologic examination shows dense fibrosis and glandular structures in the wall of the gallbladder. What is the most likely diagnosis?Carcinoma of the gallbladderHemangiosarcomaHepatic adenomaHepatocellular carcinoma  <response>: Adenocarcinoma of the gallbladder Arises from the mucosal surface epithelium - Obstructive jaundice as in this case by involvement of the extrahepatic biliary tree. The other choices are not associated with a history of chronic cholecystitis and cholelithiasis and infrequently cause obstructive jaundice. 