<prompt> A 55-year-old female patient presents with duodenal ulcer. The most sensitive test to detect Helicobacter pylori isUrea breath testcultureHistologySerology  <response>: Urea breath test is the most sensitive test for diagnosis of Helicobacter pylori infection. Urea breath test: The patient drinks a solution of urea labeled with a radioactive Carbon-14 and then blows into a tube. If H. pylori urease is present, the urea is hydrolyzed, and labeled carbon dioxide is detected in breath samples. Reference: Ananthanarayan and Paniker;s Textbook of Microbiology Tenth edition 