<prompt> Liddle syndrome is characterized byHypokalemic metabolic alkalosis with hypotensionHypokalemic metabolic alkalosis with hypertensionHyperkalemic metabolic acidosis with hypotensionHyperkalemic metabolic acidosis with hypertension  <response>: Liddle syndrome is an autosomal dominant disorder with genetic defectgain of function mutation in collecting tubules sodium channel, resulting in increased tubular sodium reabsorption. 