<prompt> Lactic acidosis in thiamine deficiency is due to which enzyme dysfunction?Phosphoenol Pyruvate CarboxykinasePyruvate DehydrogenasePyruvate CarboxylaseAldolase  <response>: In Thiamine deficiency, PDH reaction is defective. So, pyruvate is converted to lactic acid.Causes of inhibition of PDH leading to lactic acidosis:Inherited PDH deficiencyThiamine deficiencyAlcoholics due to thiamine deficiencyArsenite and Mercury poisoningHarper 30th edition 