<prompt> Eteplirsen has been recently FDA approved for the treatment ofDuchenne muscular dystrophySpinal muscular atrophySSPEAML  <response>: Duchenne muscular dystrophy: MC hereditary neuromuscular disease in children. X-linked recessive deletion of dystrophin gene Xp 21- one of the largest gene CF: More common in males. Family history present Pseudohyperophy of calf muscles Cardiac involvement Recurrent respiratory infection Proximal muscle weakness in limbs Intellectual disability GOWER SIGNis positive- Gowers sign indicates weakness of the proximal muscles, esp of the lower limb. Mx- Phase 3 trials have shown benefits from ETEPLIRSEN - FDA APPROVED 