<prompt> In a case of acute exacerbation of asthma, salbutamol was given and no improvement noticed, intravenous corticosteroids and aminophylline was given and condition improved. What is the mechanism of corticosteroid in acute asthma?Corticosteroid increase bronchial responsiveness to salbutamolCorticosteroids cause direct bronchodilation when used with xanthinesCorticosteroids indirectly increase the effect of xanthines on adenosine receptorCorticosteroids increase mucociliary clearance.  <response>: ANS. ACorticosteroids has a dual effect in acute asthma with an early facilitatory effect on airway beta 2 adrenoreceptor sensitivity and a later effect on airway inflammation, which further emphasizes the need for corticosteroids to be administered as early as possible during an acute asthma attack. Newer monoclonal antibodies in respiratory condition1. Pitakinra: IL-3 and 4 antagonist used in bronchial asthma2. Resilizumab: IL-5 antagonist used in bronchial asthma3. Mepolizumab: IL-5 blocker useful in hypereisnophilic vasculitis4. Omalizumab: Against IG E in bronchial asthma5. Pavilizumab: Used against respiratory syncitial virus AIIMS November 2016. 