<prompt> Most characteristic features of actual inflammation in-VasoconstrictionVascular stasisVasodilation and increased vascular permeabilityMargination of leukocytes  <response>: EFFECTS OF VARIOUS MEDIATORSo Various effects of inflammatory mediators are1. Increased vascular permeability Histamine, serotonin 5-hydroxytryptamine, anaphylatoxins C3a, C4a, C5a, PAF, leukotrienes LTC4, D4, E4, bradykinin. PAF is the most potent one to increase permeability.2. Chemoattractant C5a most potent, IL-8, LTB4, PAF, bacterial products, Lymphokine, Kallikrein. C5a is the most potent chemoattractant.3. Vasodilatation Histamine, prostaglandins PG D2, PGE2, prostacyclin PGI2, serotonin. Nitric oxide, bradykinin.4. Vasoconstriction Leukotrienes LTC4, D4, E4, Thromboxane A2.5. Bronchoconstriction Leukotrienes LTC4, D4, E4, PFA, histamine, bradykinin. Leukotrienes LTC4, D4, E4 are the most potent bronchoconstrictors.6. Pain Prostaglandins, bradykinin.7. Fever pyrogens IL-1, TNF-αl IL-6, prostaglandins, interferon. 