<prompt> Which of the following agents enhances the bioavailability of levodopa in patients with Parkinsons disease:AmantadineRopiniroleEntacaponeSelegiline  <response>: Entacapone tolacapone which cones under COMT INHIBITORS enhance prolong the therapeutic effect of levodopa-carbidopa in advanced fluctuating PD . Ref: KD Tripathi 8th ed. 