<prompt> A male with insulin-dependent diabetes and having macular edema develops glaucoma. Which drug should be used as the least resort to treat?Alpha agonistProstaglandin analoguePilocarpineBeta blocker  <response>: Ans. B. Prostaglandin analoguesAlthough prostaglandin analogues are the first-line treatment for open angle glaucoma, these should not be given in case a patient with macular edema develops glaucoma. The reason for the same is maculopathy caused by prostaglandin analogues can cause blurring of vision.Extra Edge: Other drugs causing maculopathy Niacin Griseofulvin Thiazolidinediones Tamoxifen Clofazimine, chloroquine Bulls eye maculopathy PG analoguesDrugs used for treatment of macular degeneration Monoclonal antibodies: Bevacizumab, Ranibizumab Photodynamic therapy: Verteporfin Steroids Dexamethasone, Prednisolone IV Methotrexate Pegaptanib: PEGylated oligonucleotide that binds VEGF 