<prompt> Which of the following cell organelle is mainly involved during apoptosis?NucleusMitochondriaEndoplasmic reticulumGolgi complex  <response>: Loss of mitochondrial function is seen during apoptosis. Mitochondrial membrane integrity is not maintained, causing the end of normal activity and release of cytochrome c into the cytoplasm where it activates proteolytic enzymes called caspases. The initial caspases activate a cascade of other caspases, resulting in protein degradation throughout the cell. Ref: Mescher A.L. 2010. Chapter 3. The Cell Nucleus. In A.L. Mescher Ed, Junqueiras Basic Histology: Text Atlas, 12e. 