<prompt> Tobacco induced squamous cell carcinoma doesnt involve mutation inP53P16P63NOTCH 1  <response>: Tobacco carcinogens induced cancers involve a mutation in the P53 pathway as well as proteins responsible for squamous differentiation . Conversely HPV associated squamous cell carcinomas overexpress P16.Reference: Robbins; 9th edition; Volume II; Oropharyngeal squamous cell carcinoma molecular biology; Page no: 733 