<prompt> Infant with cystic fibrosis CF are likely to develop -MeconiumileusLoose motionsVomitingAll  <response>: Ans. is a i.e., Meconium ileus Cystic fibrosis o Cystic fibrosis mucoviscidosis is a hereditary disease affecting the exocrine mucus glands of the lungs, liver, pancrease and intestines, causing progressive disability due to multisystem failure. o It has an autosomal recessive pattern of inharitance. Pathogenesis o The basic defect in CF is mutation in the cystic fibrosis transmembrane regulator CFTR gene that regulates chloride conductance channel in outer membrane of exocrine glands. Clinical manifestations 1 Lungs and sinus disease Sinusitis Bronchiactasis Lower respiratory tract infection Nasal polyps Chronic lung disease Pulmonary hypeension can cause hea failure Allergic bronchopulmonary aspergillosis 2 GIT, Liver and pancrease Meconium ileus Rectal prolapse Malabsorption Pancreatitis Constipation Intussusception Meconium peritonitis Bile duct obstruction and biliary cirrhosis 3 Endocrine and growth Diabetes Osteoporosis Poor growth 4 Infeility In men due to absence of vas deference In women due to thick cervical mucus. 