<prompt> Multiple drug resistance is spread by -TransformationTransductionMutationConjugation  <response>: Ans. is d i.e., Conjugation Drug resistance Mutation Genetic transfer Stepwise mutationOne-step mutationTransformationTransductionConjugationo Not significant resistanceo Penicillino Transmitted by R factoro Resistance to multiple drugsPenicillinStreptomycin 