<prompt> Which of the following is true regarding concentration of proteins in senile cataract?More insoluble protein, less soluble proteinMore soluble protein, less insoluble proteinEqual concentration of soluble and insoluble proteinNone of the above  <response>: Ans. a. More insoluble protein, less soluble protein Ref: Exp Eye Res. 2004 July; 791: 3-9. Molecular genetics of age- related cataract by J. Fielding Hejtmancika and Marc KantorowbLenses with cataracts contain more insoluble proteins.Lens ProteinsThe lens is very high 35 in protein and is therefore sensitive to protein deficiency.In young individuals, most lens proteins are soluble alpha, beta and gamma crystallines.Lenses with cataracts contain more insoluble proteins.With age, some crystallines become insoluble which is important in senile cataractogenesis.The lens capsule immunologically walls off the lens proteins from the immune system. 