<prompt> Acantholysis is seen in all except ___:Pemphigus vulgarisDariers diseaseStaphylococcal scalded skin syndromeBullous pemphigoid  <response>: Ans. D. Bullous pemphigoid Acantholysis is not seen in Bullous pemphigoid. Acantholysis is the loss of intercellular connections, such as desmosomes, resulting in loss of cohesion between keratinocytes.Acantholysis may be either primary or secondary:Primary Acantholysis Primary acantholysis is due to the rupture of desmosome first, resulting in circular cells acantholytic cell. It is seen in conditions such as Pemphigus vulgaris, Staphylococcal scalded skin syndrome, Dariers disease, Hailey disease.Secondary Acantholysis Secondary acantholysis is due to the ballooning of the keratinocyte first, leading to the formation of circular acantholytic cell also known as Tzanck Cell. It is seen in Herpes simplex infections HSV 1 and 2 and Varicella zoster infections Chicken pox and Shingles.Acantholysis; note the rounded and free-floating, detached keratinocytes 