<prompt> Which of the following is associated with an intrinsic defect in RBC membraneAutosomal hemolytic anaemiaHereditary spherocytosisMicroangiopathic haemolytic anaemiaThermal injury causing anaemia  <response>: Ref Robbins 9e p632regarding hereditary spherocytosis: this inherited disorder is caused by intrinsic defects in the red cell membrane that render red cells sheroid ,less deformable, and vulnerable to splenic sequestration and destruction Other disorders with intrinsic defect in red cell membrane are hereditary elliptocytosis and abetalipoproteinemia 