<prompt> A perimenopausal woman on Pap smear has repoed ASCUS atypical squamous cell of unknown significance. Next line of management is:Loop excisionConizationColposcopyHysterectomy  <response>: In Bethesda system, the most common cytological abnormality is atypical squamous cells ASC. ASC is fuher divided into ASCUS atypical squamous cell of unknown significance and ASC-H atypical squamous cells where HSIL cannot be ruled out. The risk of progression of ASCUS to CIN is 5. These patients should be followed up with: 1. HPV DNA testing 2. Immediate colposcopy 3. Repeated cytology at 6-12 months Ref: GYANECOLOGICAL DIAGNOSIS ; Novak, 15th edition, page 587q 