<prompt> Which of the following is least commonly involved organ system in Hemochromatosis:LiverSkinJointsEye  <response>: Answer is D Eye: Refer Notes on Hemochromatosis Ocular involvement in Hemochromatosis is unusual but may manifest as Limbal or Diffuse Conjunctival pigmentation Liver is usually first organ to be affected and hepatomegaly is seen in 95 of .symptomatic patients. Skin involvement Bronzing of skin is present in 90 of symptomatic patients. Joint involvement Ahropathy develops in 25-50 of patients. 