<prompt> Insulin-like growth factor-II IGF-II is synthesized in all EXCEPT:BrainLiverCailagePancreas  <response>: GH actions of growth of bones and visceral organs are mediated by a group of hormonesfactors called insulin-like growth factors IGFs. It is a complex system that includes: Two ligands IGF-I and IGF-II, two cell membrane receptors for these ligands IGF-IR and IGF-IIR . IGF-I is the major form produced in most adult tissues; IGF-I is for achieving maximal growth. IGF-I is produced by and influences many cells in the body, especially cells in muscle, cailage, bone, liver, kidneys, nerves. IGF- II is the major form produced in the fetus. IGF-II is the growth factor for early fetal growth and development; IGF-II is produced by brain, kidney, pancreas, and muscle. Both IGFs are produced by the liver, in response to a GH stimulus. Among the options given in this question, cailage synthesizes IGF-I. Hence, it is the answer. 