<prompt> Fasciculations are caused byScolineKetamineHalothaneAtracurium  <response>: Ans. a Scoline. Ref. KD Tripathi, Pharamacology, 6th ed., 150SUXAMETHONIUM CHLORIDE OR SUCCINYL CHOLINE SCOLINEIntroduction- It is a short acting muscle relaxant.- It is a phase II blocker.- Depolarising muscle i.e. depolarising block at motor end-plate.- It is dichlor ester of succinic acid.- The action lasts for 3-5 minutes.- Action is prolonged in liver disease.- Metabolised by pseudocholinesterase.- It gives good intubating condition in shortest time less than one minute.Uses- Endotracheal intubation in dose of 1 to 2 mgkg body weight.- To modify electroconvulsive therapy.- For procedures requiring short duration relaxation.- Excellent for operative abet and caesaerian section.Side effectsMnemonicABRHAM on FTV- Apnoea Prolonged,- Bradycardia,- Raised intraocular pressure- Hyperkalemia- Ache Myalgia Post-operative muscle ache- Malignant hyperpyrexia- Fasciculation,- Tachyphylaxis- Ventricular fibrillationIts SE can be prevented by- Self-taming with 10 mg suxamethonium given a minute before induction of an anaesthesia.PrecurarizationAlso remember: Malignant hyperpyrexia:- It is due to release of Ca from sarcoplasmic reticulum in sensitive person- It can be caused also bya Halothane,b Methoxyflurane andc Isoflurane- Rx- dantrolene.- Dantrolene is muscle relaxant acting directly on muscle. MH 2006 