<prompt> A patient got exposed to Hepatitis B infection. Which of the following markers will always be present in the patient even he becomes chronic or recurrent?Hbs AgAnti HBs AbHbc ABHbe Ag  <response>: Ans. c Hbc ABRef: Ananthanarayan and Panikers Textbook of Microbiology - 10th ed - page 550 HbcAg - cannot be demonstrable in blood The earliest antibody marker to be identified is Anti HbcAg -IgM After six months IgG starts appearing Question dint mention IgM or IgG hence thats the answerHBs AgHBe AgAnti HBcAnti HBsAnti HBeInterpretationIgM--Acute HBV infection; highly infectiousIgG--Latechronic HBV infection or carrier state; highly infectious-IgG--LateChronic HBV infection or carrier state; low infectivity--IgM--Seen rarely in early acute HBV infection; infectious--IgG--Remote HBV infection; infectivity nil or very low----Immunity following HBV vaccine 