<prompt> Massive splenomegaly with pancytopenia -CLLPure red cell aplasiaCMLMyelofibrosis  <response>: Ans. is d i.e., Myelofibrosiso Massive splenomegaly is referred to as extension of spleen greater than 8 cm below the left costal margin or weight of spleen more than 1 Kg.o Causes of massive Splenomegaly are - CML Polycythemia vera Autoimmune hemolytic anemia Lymphomas Gauchers disease Diffuse splenic hemangiomatosis Hairy cell leukemia CLL Myelofibrosis Sarcoidosiso Amongst these conditions pancytopenia is seen in i.e., massive splenomegaly with pancytopenia : - o Hairy cell leukemia Myelofibrosis Gauchers disease 