<prompt> A new born presented with bloated abdomen sholy after bih with passing of less meconium. A full thickness biopsy rectal biopsy finding is most likely to be present.Fibrosis of submucosaHyalinisation of the muscular coatThickened Muscularis propriaLack of ganglion cells  <response>: .hirschsprung disease is a congenital, familial condition, occurring in newborn due to the absence of ganglion cells-- Auerbachs and Meissners plexus in anorectum, which may extend proximally either a pa or full length of the colon. It always involves the anus, internal sphincter and rectum paly or entirely. There is narrow, spasmodic, non relaxing pathological segment. Transitional zone proximal to it contains only few ganglion cells with formation of cone. ref:SRB;s manual of surgery,ed 3,pg no 818 