<prompt> Symptomatic neonatal CNS involvement is most commonly seen in which group of congenital intrauterine infection?CMV and toxoplasmosisRubella and toxoplasmosisRubella and HSVCMV and syphilis  <response>: c. Rubella and HSVRef: Nelsons 20e p 1548-1551Symptomatic CNS infections in neonatal period are most commonly seen in HSV 75-100 fb Rubella 30-60;CMV, toxoplasma, and syphillis become symptomatic in less than 10-15 of cases.Characteristic clinical features of Intrauterine InfectionsInfectionIUGRHSMBleedingEye signsCNS featuresOthersConge-nital CMV disease60-7023rd of patientsBlue berry muffinspotsCottage cheese with Ketchup choriore-tinitis,sparing of macula, optic atrophyMicro-cephaly, periven-tricular calcifi-cation,mental retardationAnemia, sensori-neural deafness, pneumoniaConge-nitalRubella6060-7050-60Cataracts, glaucoma, corneal opacity,salt pepper choriore-tinitisMeningo-encephalitis, deafness, mental retardationCardiac defects like PDA, PS, VSD; bone lesionsConge-nital Toxopla-smosis20-3040-5030-40Choriore-tinitis with macular involve-ment, optic atrophy, cataract, uveitisHydroc-ephalus, microce-phaly, Diffuse cerebral calcifi-cationStrabismus, nystagmus, visual impairmentConge-nitalsyphilisUncom-mon30-40Uncom-monInterstitial Keratitis, Choriore-tinitisMeningo-encepha-litisRashes, snuffles,periosteitis, chondritis, deafnessConge-nitalVaricellaLBWcommonUncom-monUncom-monChoriore-tinitis, microph-thalmia, and cataractsMicroce-phaly, cortical atrophy, seizures, ID, neurogenic bladder, swallowing dysfunctioncicatricial skin scarring in a zoster-like distrib-ution; limb hypoplasia; hydron-ephrosisHerpessimplexNone50Uncom-monKeratitis, Conjun-ctivitis, Choriore-tinitis, CataractsMeningo-encephalitis, micro-cephaly, Intracranial CalcificationVesicles, Pneumonia, Hepatitis, mucocu-taneous lesions 