<prompt> Treatment of choice of stage III CIN in 40-year-old female is:HysterectomyLaser coagulationCryocoagulationCone excision  <response>: As discussed in preceding text - management options in CIN areAblative techniques like cryosurgery, laser vaporization therapyExcisional methods - like LEEP Loop electro excisional procedure or LLETZlarge loop excision of transformation zone, condition surgeryHysterectomyIn general, the major drawback of ablative procedures is - it destroys the tissue and so no tissue specimen is available for additional histologic evaluation during follow-up.Cryotherapy: It should be considered only if. There is a minor degree of CIN localized and it isThis method is ideal for minor degrees and localized CIN - Dutta 6th ed p 327Thus in this patient - cryotherapy will not be done as she has CIN IIILaser ablation: Rarely used in practice. Used only if CIN extends to vaginal fornices.RememberMost early CIN is now managed expectantly so the need for ablation is decreasing.Hysterectomy: As far as hysterectomy is concerned - it is taken as too radical a procedure for management of CIN and is reserved for special circumstances like recurring CIN -Recent management says whether the patient is young or old -CIN111 should be managed by LEEPLLETZ. 