<prompt> Intra arterial injection of thiopentone causesVasospasmVasodialationNecrosis of vessel wallHypotension  <response>: Inadverent intra-arterial injection causes local vasoconstriction vasospasm and thrombosis which can cause ischemia and gangrene of the limb.Note-IV injection cause generalized venodilatation due to which there is pooling of blood hypotension. On the other hand intra-arterial injection results in localized vasospasm of the involved artery. 