<prompt> Which anesthetic is contraindicated in renal failure-IsofluraneDesfluraneHalothaneMethoxyflurane  <response>: Ans. is d i.e., Methoxyflurane Methoxyflurane o It was most potent inhalation agent least MAC, but is not used now Halothane is most potent, o It should not be used in a closed circuit reacts with rubber tubing of the closed circuit. o It has slowest onset recovery however now ether has slowest onset recovery as methoxyflurane is not used, o The boiling point is more than water 104degC. o Intrarenal metabolism of methoxyflurane and subsequent intrarenal production of fluoride ion is the significant cause of methoxyflurane renal toxicity, o It can cause high output renal failure and hepatotoxicity. 