<prompt> Digeorge syndrome is due to defect of?pouch 1pouch 2pouch 3 and 4pouch 5  <response>: Digeorge syndrome is due to defect of pouch 3 and 4. Pouch 3 compromised - No thymus - CMI decreases - Severe bacterial infections Pouch 3 4 compromised - absent or poorly developed parathyroid - low PTH - Hypocalcemia. 