<prompt> Premalignant bone lesion among the following is -Pagets diseaseOsteoid osteomaOsteochondromaEnchondroma  <response>: Ans. is a i.e., Pagets disease Pagets disease o Paget s disease is characterized by increased bone turnover and enlargement and thickening of the bone the internal architecture is abnormal and the bone is usually brittle, o Primary defect is in osteolastic. o It is marked by regions of furious osteolastic bone resorption which is followed by a period of hectis bone formation. The net effect is gain in bone mass. o It has the following three stages Initial osteocytic stage Mixed osteoclast osteoblastic stage Burned out quiescent osteosclerotic stage o Following complications can occur in Pagets Increased risk of development of sarcomas osteosarcoma chondrosarcoma Fractures in weight bearing bones Osteoarthritis High output cardiac failure Cranial nerve compression Otoscleosis 