<prompt> History of dislike for sweet food items is typically present in:Diabetes mellitusGlycogen storage diseaseHereditary fructose intoleranceGalactosemia  <response>: Ans. is c i.e. Hereditary fructose intoleranceRef.: Harrison 17the p 2458 16the p 2321 15the p2289 In hereditary fructose intolerance patients are healthy and asymptomatic until fructose or sucrose table sugar is ingested. With the ingestion of sugar severe clinical symptoms appear. Which are -JaundiceHepatomegalyVomitingLethargyIrritabilityConvulsionsProteinuriaHereditary fructose intolerance is caused by the deficiency of Aldolase B.Aldolase B catalyzes the following reactionFructose - 1 - phosphate Aldolase B Glyceraldehyde Dihydroxyacetone phosphate Deficiency of this enzyme causes rapid accumulation of fructose -1- phosphate and initiates severe toxic symptoms when exposed to fructose.Diagnosis -It is diagnosed by the presence of reducing substance fructose in the urine.The appearance of hypoglycemia and hypophosphatemia after fructose 200 mgkg loading is diagnosticTreatment:Treatment consists of eliminating fructose from the dietAs affected individuals grow up they may recognize the association of nausea and vomiting with fructose containing foods and selectively avoids them 