<prompt> The ratio of the dose that produces toxicity to the dose that produces a clinically desired or effective response in a population of individual is Known asEfficacyPotencyTherapeutic indexPartial agonist  <response>: Therapeutic Index 55- KDT6th 32-33-LP3rdTherapeutic Index - The therapeutic index of a drug is ratio of the dose that produces toxicity to the dose that produces a clinically desired or effective response in a population of individuals A drug may be capable of inducing a higher therapeutic response have higher efficacy but development of intolerable adverse effects may preclude use of higher doses eg prednisolone in bronchial asthma The therapeutic index is thus measure of a drugs safetyTherapeutic Index LD50Median lethal dose---ED50Median effective dose Warfarin - anticoagulant with a small therapeutic index Penicilline - antimicrobial with a large therapeutic indexPotency - a measure of the amount of drug necessary to produce an effect of a given magnitude. For a number of reasons, the concentration producing an effect that is 50 of the maximum is used to determine potency i.e. EC50 EC50 is the concentration of the dnig that produces a response equal to fifty percent of the maximal responseEfficacy - is dependent on the number of drug- receptor complexes formed and the efficiency of coupling of receptor activation to cellular responses Emax Efficacy is more important than potency A drug with greater efficacy is more therapeutically beneficial than one that is more potent Small the EC50 the more potent the drug 