<prompt> Wernicke encephalopathy is due to acute dietary deficiency of:Folic acidNicotinic acidThiaminePyridoxine  <response>: Wernickes ophthalmoparesis, ataxia, and encephalopathy and Korsakoffsretrograde and anterograde amnesia syndrome is common in alcoholics due to thiamine deficiency. Pathogenesis:- Thiamine is needed for oxidative decarboxylation reactions pyruvate dehydrogenase and a-ketoglutarate dehydrogenase that are very impoant for the metabolism of glucose. Thiamine deficiency produces a diffuse decrease in cerebral glucose utilization and results in mitochondrial damage. Glutamate accumulates due to impairment of a-ketoglutarate dehydrogenase activity and, in combination with the energy deficiency,may result in excitotoxic cell damage. 