<prompt> Which of the following circulating antibodies has the best sensitivity and sepcificity for the diagnosis of celiac disease -Anti-endomysial antibodyAnti-tissue transglutaminase antibodyAnti-gliadin antibodyAnti-reticulin antibody  <response>: IgA anti-endomysial antibodies are found in 90 coeliac patients. They are a very specific sensitive marker for coeliac disease and dermatitis herpetiformis. The anti-endomysial antibody test has been suggested to be 98 sensitive and 98 specific for clinical or subclinical coeliac disease Ref Davidson edition23rd pg 805 