<prompt> Vigorous treatment of nephritis in SLE is indicated in:Class I IIClass III IVClass IV VClass V VI  <response>: Renal Biopsy in SLE: The pattern and severity of injury are impoant in diagnosis and selecting the best therapy. Aggressive immunosuppressive treatment is indicated in : Class III and IV disease Class V accompanied by III or IV disease Treatment for lupus nephritis is not recommended in class I or II disease or with extensive irreversible changes. Classification of Lupus Nephritis International Society of Nephrology and Renal Pathology Society Class I: Minimal Mesangial Lupus Nephritis Class II: Mesangial Proliferative Lupus Nephritis Class III: Focal Lupus Nephritis Class IV: Diffuse Lupus Nephritis Class V: Membranous Lupus Nephritis Class VI: Advanced Sclerotic Lupus Nephritis Ref:Harrison,E-18,P-2733 