<prompt> Normal adult GFR is100- 120 mlmin, 173 m sqcm2120- 130 mlmin, 173 m sqcm2130- 140 mlmin, 173 m sqcm2140 - 150 mlmin, 173 m sqcm2  <response>: 120-130 mlmin, 1.73 msqcm2 706-GN 646- Ganong 23rd The GFR in an average-sized normal man is approximately 125 mLmin. Its magnitude correlates fairly well with surface area, but values in woman are 10 lower than those in men even after correction for surface area.Factors that can decrease the GFR 288-Gyton 10thPhysiologic Pathophysiologic causes Renal disease, DM, hypertension Urinary tract obstruction eg. Kidney stones Renal blood flow, increased plasma proteins Arterial pressure has only small effect due to autoregulation Angiotensin II drugs that block angiotensin II formation Sympathetic activity, vasoconstriction hormones eg. Norepinephrine, endothelin 