<prompt> In thymus, which gene is responsible for recognition of self-antigens?NOTCH 1AIRERbPTEN  <response>: Immunologic tolerance is the phenomenon of unresponsiveness to an antigen induced by exposure of lymphocytes to that antigen. A protein called AIRE autoimmune regulator stimulates expression of some peripheral tissue-restricted self-antigens in the thymus It is critical for deletion or negative selection of immature T cells specific for these antigens. Mutations in the AIRE gene are the cause of an autoimmune polyendocrinopathy. In the CD4 T-cell lineage, some of the cells that see self-antigens in the thymus do not die but develop into regulatory T cells. 