<prompt> Acantholysis is:Lysis of basale cell layerSeparation of keratinocytesThickening of granular layerThickening of corneum layer  <response>: Ans. b Separation of keratinocytesRef: Harrison 19th ed. 370 Keratinocytes are connected to one another by intracellular desmosomal bridges. If there is loss of these desmosomal bridges, it will lead to separation of keratinocytes and the condition is known as acantholysis. If separation continues, there will be intracellular edema, and the condition is known as Ballooning.Also Know Degeneration of stratum basale is seen in: Lichen planus Acanthosis: thickening of stratum spinosum Hypergranulosis: Thickening of stratum granulosum Hyperkeratosis: Thickening of stratum corneum Parakeratosis: persistence of nucleus in stratum corneum layer 