<prompt> A 34-year-old man is referred for evaluation of hypeension and persistent hypokalemia in spite of taking oral potassium supplements. Blood pressure is 180110 mm Hg. Serum sodium is 149 mEqL normal 140 to 148 mEqL; potassium, 3.3 mEqL normal 3.6 to 5.2 mEqL; Bicarbonate, 29 mEqL normal 22 to 29 mEqL; Chloride, 103 mEqL normal 98 to 107 mEqL; and Urea nitrogen, 23 mgdL normal 7 to 18 mg dL. Computed tomography demonstrates a 3-cm mass in the right adrenal gland. The most likely diagnosis isConn syndromeAddison disease.Cushing syndrome.Sipple syndrome.  <response>: - Combination of hypeension, persistent hypokalemia slightly elevated serum sodium- Hyperaldosteronism along with mass in adrenal gland suggests towards Conn syndrome primary hyperaldosteronism. - Diagnosis can be confirmed by demonstration of: Aldosterone, Lack of response of aldosterone to sodium loading Serum renin levels. 