<prompt> Which is seen in chediak Higashi syndromeNeutopeniaDefective microbial killingPresence of large granules in neutrophilsAll of the above  <response>: Ref Harrison 16e p,353:,354, Robbins 9e p238 Chediak Higashi syndrome: Autosomal recessive inheence Due to defect in lysosomal transpo protein LYST. Clinical feature include: primary immune deficiency, neutropenia , defective microbial killing,impaired chemotaxis,hypopigmentation, photophobia, nystagmus. Microscopic examination shows giant peroxidase positive inclusion in the cytoplasm of leukocytes 