<prompt> A child with pellagra like symptoms, amino acids in urine, family history of one siblings affected and three normal. Parents are normal. What is the diagnosis?PhenylketonuriaAlkaptonuriaMaple syrup urine diseaseHanups disease  <response>: Diagnosis is Hanups disease. autosomal recessive normal carrier parents with 25 of their children are affected There is failure to reabsorb tryptophan from urine.So, tryptophan comes in urine Aminoaciduria . Patient has Pellagra like symptoms as Tryptophan forms Niacin - Vitamin B3 in body. Fig:-NORMAL AND ABNORMAL ROUTES OF TRYPTOPHAN Treatment: 1. Niacin 2. High protein diet 