<prompt> Which of the following anticancer drugs can cause a hypercoagulable state5FULasparginaseMelphalanCarmustine  <response>: L-asparginase causes the breakdown of aspargine and thus interferes with protein synthesis. It can inhibit the production of clotting factors responsible for cerebral hemorrhage as well as anti-clotting proteins can lead to cortical vein thrombosis and other hypercoagulable states. 