<prompt> Which of the following is not a mechanism for resistance to MRSAResistance is chromosomally mediatedProduced mainly by alteration in PBPsMRSA resitance is absolutely beta lactamase dependentIntrinsic resistance is known  <response>: Methicillin-resistant Staphylococcus aureus MRSA infection is caused by a type of staph bacteria thats become resistant to many of the antibiotics used to treat ordinary staph infections. Penicillin resistance is of three types: Production of beta-lactamase Alteration in the penicillin-binding protein PBP2a and changes in bacterial surface receptors, reducing binding of beta lactam antibiotics to cells. This resistance also extends to cover beta-lactamase-resistant penicillins such as methicillin and cloxacillinsMRSA. Some of the strains may show resistance to other antibiotics such as erythromycins, tetracyclines, aminoglycosides, and heavy metals and cause outbreaks of hospital infections. Development of tolerance to penicillin Ref: Textbook of Microbiology; Ananthanarayanan and Panicker; Tenth Edition; Page No: 202 