<prompt> All the following are the effects of oestrogen, EXCEPT:Beneficial effect on cognitionReduced osteoclastic activityIncreased osteoblastic activityIncreased protein C and S levels  <response>: The effects of oestrogen on the skeletal system includes: 1 Increased osteoblastic activity 2 Reduced osteoclastic activity 3 Prevents osteoporosis 4 Promotes fusion of epiphyses Also know Oestrogen increases factor II, III, IX, X, XII and decreases protein C , S and antithrombin III. Ref: Essentials of Gynaecology by Lakshmi Seshadri, Edition 1, page - 44 