<prompt> Which of the following is poor prognostic factor in a child with ALL?Age 2-8 yrsTotal leucocyte count 50,000t 9;22; t 4;11; t 1;19Absent blasts in peripheral smear  <response>: Specific chromosomal translocations in ALL,including t8;14,associated with Burkitt leukemia,t4;11 in infant leukemia,t9,22translocation that forms the Philadelphia chromosome,t1,19 translocation associated with probable CNS relapse,are associated with a poor prognosis.The age group of 2-10 yrs have satisfactory prognosis.Other good prognostic factors include initial WBC count 50,000 and absence of blasts in peripheral smear following response to treatment with prednisone. t 9:2, t 8:14, t 4:11 is a poor prognostic factor . Reference:Essential pediatrics-Ghai,8th edition,page no:601 