<prompt> AML with adverse prognosis is:t8;21t15;17Normal cytogeneticsDel 7q  <response>: Prognostic factors in AML A. Favourable prognostic factors B. Unourable prognostic factors Age 40 years AML without antecedent MDSMPD Blast cells with Auer rods TLC 25 x 109L FAB subtype-AML-M2, M3, M4 High WBC Count 100 x 109L AML with preceding MDSMPD Extremes of age2years and 55years -77q- Extramedullary disease in AML-M5 Presence of CNS involvement FAB subtype - AML - M0, M6, M7 t 15;17 in AML- M3-PMLRARA ve t 8;21 in AML- M2 Ivn 16 in AML - MYH11 mutation NPM1 mutations without FLT3 mutations Biallelic CEBPA gene mutations. MLLT3 -KMT2A intermediate prognosis Trisomy 8 del 7q del 5q 11q23-MLL ve 3q21 Del 7q Expression of MDR-1 gene multidrug gene 3q26 t9; 11 complex Karyotypes Normal cytogenetic inv3; t3; 3 t6:9 FLT -3 mutation ITD are worse than TKD MLL gene rearrangement RAS gene mutations KIJ gene mutationsp p53 gene mutations ERG gene mutations MN1 gene mutations RUNX1 mutation BCR-ABL 1 mutation 