<prompt> Endogenous pyrogens act by -Increasing heat generationRaising thermostat point of hypothalamusCausing vasoconstrictionBy Non-shivering thermogenesis  <response>: Ans. is b i.e., Raising thermostat point of hypothalamus o Bacterial toxins exogenous pyrogens stimulate inflammatory cells to secrete pyrogenic cytokines endogenous pyrogens, e.g. IL-1, TNF-a , and IL-6.o These endogenous pyrogenes stimulate PGE2 release in hypothalamus, which raises temperature set point of hypothalamus to cause fever.Endotoxin inflammationOther pyrogenic stimuliMonocytesMacrophagesKupffer cells CytokinasePreoptic area of hypothalamus ProstaglandinsRaise temperature set pointFeverPathogenesis of fever 