<prompt> Menkes disease is due to deficiency of:SeleniumCopperChromiumManganese  <response>: Ans. b CopperRef: Harrisons 20th ed. P 2318Menkes Kinky Hair Syndrome X-Linked metabolic disturbance of copper metabolism Characterized by: Mental retardation Hypocupremia Decreased circulating ceruloplasmin Due to mutation in ATP7-A gene copper transporting gene Cause of death: Dissecting aneurysm or cardiac rupture usually 5 years of age Wilsons disease: Copper accumulation in liver, brain; due to mutation in ATP7-B gene. Acrodermatitis enteropathica: AR condition. Due to zinc deficiency Chromium potentiates the action of insulin and improves lipid profile Keshan disease: Endemic cardiomyopathy, due to dietary deficiency of selenium Kashin-Beck diseaseSelenosis: Chronic ingestion of large amount of selenium. Characterized by hair loss and nail brittleness, garlic breath odor, rash, myopathy etc. 