<prompt> Most specific antibody in SLE is -Anti nuclearAnti SmAnti RoAnti histone  <response>: Ans. is b i.e., Anti Sm Auto anti bodies in Systemic Lupus Erythematosuso Antinuclear antibody-best screening test.o Anti DS DNA antibody-Specific for SLE only in high litres.o Anti Smantbody-Specific for SLE.o Anti Ro SS - A antibody-Predisposes to Sicca syndrome, subacute cutaneous lupus and neonatal lupus with congenital heart block.o Anti histone antibody-Associated with drug induced lupus. 