<prompt> Which of the following colonic polyps is not pre-malignant?Juvenile polypsHamaomatous polyps associated with PeutzJeghers SyndromeVillous adenomasTubular adenomas  <response>: Answer is A Juvenile Polyps: Juvenile Polyps is the single best answer of choice. Juvenile polyps sporadic, in general occur singly and being hamaomatous lesions have no malignant potential-Robbins Juvenile polyps are benign polyps - Sabiston Pathologically hamaomas are considered benign and devoid of malignant potential. However hamaomatous polyps associated with Autosomal dominant hereditary syndromes have now been established to carry a small malignant potential Rare Juvenile Polyps are benign but Juvenile Polyps in association with Juvenile Polyposis syndrome carry small malignant potential. The juvenile polyps in Juvenile polyposis syndrome are usually hamaomas but they may contain adenomatous elements and may progress to adenomas. This syndrome is associated with increased risk of 9 - 25 of colorectal cancer. Mutation in Tumor supressor gene SMAD4 are believed to cause 50 of Repoed cases. Sporadic Hamaomatous polyps are benign but Hamaomas in association with Peutz Jaghers Syndrome may carry a small malignant potential. Peutz Jaghers Syndrome is associated with increased risk 2-10 of cancer in the intestinal tract. Sabiston The malignant potential of polyps associated with Peutz Jaghers Syndrome is small - CSDT. Review of Hereditary gastrointestinal polvposis syndromes Hereditary autosomal dominantQ gastrointestinal polyposis syndromes High Malignant Potential Q histologically adenomas Q Rare small Malignant Potential Q histological hamaomas e Syndrome Distribution Associated Syndrome Distribution Associated Familial colonic Large intestine None Peutz SI LI Stomach Mucocutaneous Polyposis Gardners syndrome Large intestine small intestine Osteomas Lipomas Fibromas Jaghers syndrome pigmentations Tumours of ovary, Breast, pacnreas, endometrium Turcots syndrome Large intestine Epidermal cyst Ampullaty Ca Desmoid Brain Tumours Juvenile polyposis syndrome LI SI Stomach Various congenital abnormalities 