<prompt> Ideal time for doing Quadruple test?15-18 weeks12-14 weeks10-12 weeks8-10 weeks  <response>: Ref. The Short Textbook of Pediatrics. Pg 600 Triple and Quadruple testThe triple screening measures the amounts of three substances in a pregnant womans blood: alpha-fetoprotein AFP, human chorionic gonadotropin hCG, and estriol uE3The quad screen test is a maternal blood screening test that looks for four specific substances: AFP , hCG , Estriol, and Inhibin-AIndicationsHave a family history of birth defectsAre 35 years or olderUsed possible harmful medications or drugs during pregnancyHave diabetes and use insulinHad a viral infection during pregnancyHave been exposed to high levels of radiationTimingThe triple screen test is performed between the 15th and 18th week of pregnancy 