<prompt> Urgent reversal of warfarin therapy can be done by administration of-CryoprecipitatesPlasma concentratesFresh frozen plasmaPacked red cells  <response>: Ans. is c i.e., Fresh frozen plasma Management of warfarin induced bleeding Goodman Gilman 11th e p. 1478 o Management of warfarin induced bleeding is guided by clinical state and INR. INR is 5 but above therapeutic range -Temporarily discontinue warfarin and restart at a lower dose once the INR is within the therapeutic range. If INR is between 5 - 9 - Vitamin K1 phytonadione at 1-2.5 mg oral. INR is between 9-20 - Vitamin K1 at 5 mg oral. If INR is 20 or serious bleeding -Immediate hemostatic competence is necessary. Fresh frozen plasma is transfused immediately supplemented with 10 mg vit Kt intravenous. Fresh frozen plasma replenishes the vit K dependent factor immediately. Alternative to fresh frozen plasma, fresh blood transfusion supplies clotting factors or prothrombin complex concentrate containing factor II, IX and X can be used. This treatment renders the patient refractory to oral anticoagulants but not to heparin. Now see the question o Urgent reversal of warfarin therapy is required when immediate hemostatic competance is necessary because of serious life threatening bleeding or when INR 20. o In these situations FFP is the treatment of choice, which is supplemented with vit K1. 