<prompt> Dents disease is characterized by all exceptChloride channel defectMales are affectedNephrolithiasisDefect in limb of Loop of Henle  <response>: Answer- D. Defect in limb of Loop of HenleDents disease refers to heterogenous group of X-linked disorders. It b characterized by manifestations of proximal tubule dysfunction PT dysfunction associated with hypercalciuria nephrolithiasis, nephrocalcinosis and progressive renalfailureThese features are found in males only.mutation in gene encoding CLS-S, a Voltage gated Chloide channel. 