<prompt> The most impoant determinant of prognosis in Wilms tumor:Stage of diseaseLoss of heterozygosity of chromosome 1pHistologyAge less than one year at presentation  <response>: Most impoant prognostic factor in most of malignancies- Stage TNM Exception- Wilms tumor and soft tissue sarcoma In Wilms tumor, Most impoant Prognostic Factor- Histology Stage In soft tissue sarcoma, most impoant prognostic factor - Tumor grade 