<prompt> Sensitivity of central chemorecepter in COPD -Decreased to HIncreased to HIncreased to PCO2Increased to PO2  <response>: Ans. is a i.e., Decreased to H o Primary stimulus for central chemoreceptors is an increase in hydrogen ion concentration H in CSF. o But, central chemoreceptors are depressed in hypoxia COPD causes hypoxic hypoxia. Central chemoreceptors are not stimulated by hypoxia; rather like any other cells, they are depressed by- hypoxia ___ Priciples of medical physiology o Thus, COPD will cause depression of central chemoreceptors to other stimuli as it causes hypoxic hypoxia. 