<prompt> TRUE statement about histopathological changes noticed in Wilsons disease is:Mallory denk bodies in Zone 1 is a pathognomic findingEarliest change noticed is copper deposition in mitochondriaMicronodular cirrhosis is also noticedAbsece of stainable copper in cirrhotic liver does not rule out Wilsons disease.  <response>: Histopathological changes are not specific for Wilsons disease. MUST KNOW: The earliest change is steatosis followed by peripoal glycogenated nuclei. Copper is not biochemically identifiable at this stage. Mallory denk bodies in zone 1 is a characteristic but not pathognomic finding of Wilsons disease. Absence of stainable copper in cirrhotic specimen does not rule out Wilsons disease. Macronodular cirrhosis is the most common cirrhosis noticed in wilson. Sometimes macronodular along with micronodular also noticed. Ref: Schiffs disease of liver, Edition-11, Page-811. 