<prompt> Wireloop lesions in kidney are seen inDMSLEPANScleroderma  <response>: Ans. b SLE .Ref. Robbins, Pathology, 6thpg.221SYSTEMIC LUPUS ERYTHEMATOSUS SLE Connective tissue disorder associated with HLA B8 and DR3. Onion skin lesions in spleen occur. Wire-loop lesions in kidneys are seen.- Photosensitive erythematous butterfly rash on the facediscoid rash, lupus profundus, livido reticularis.- Transient, migratory or seronegative chronic arthritis.; Bony erosions- Lymphadenopathy, Splenomegaly, Alopecia- PericarditismyocarditisLibmann Sacks verrrucous endocarditi- Pleurisy, ILD, fibrosing alveolitis, shrinking lung syndrome- Kerato-conjunctivitis sicca, episcleritis, retinal vasculitis, soft exudates- CNS features Treatment; antimalarials, immunosupressants and steroids. Congenital lupus erythematosus is characterized by- Complete heart block- Lupus erythematosus rash Drug induced lupus- Procainamide, hydralazine, phenothiazines, OC pills, anticonvulsants implicated.- Anti-histones abs - Absent anti dd DNA abs- Renal and CNS lesions. 