<prompt> Which of the following diuretics acts on nephron through interstitiumThiazideFurosemideAcetazolamideSpironolactone  <response>: Ans. is d i.e., SpironolactoneRef: KDT Vhe p. 587Spironolactone is mineralocoicoid aldosterone antagonist. It opposes the action of Aldosterone without requiring access to the tubular lumen.Spirinolactone as well as aldosterone act from the interstitial side. 