<prompt> Most common cause of mitral stenosis is:Rheumatic hea diseaseInfective-endocarditisDiabetes mellitusCongenital  <response>: The most frequent causes of the major functional valvular lesions are: Aoic stenosis: calcification and sclerosis of anatomically normal or congenitally bicuspid aoic valves Aoic insufficiency: dilation of the ascending aoa, often secondary to hypeension andor aging Mitral stenosis: rheumatic hea disease Mitral insufficiency: myxomatous degeneration mitral valve prolapse 