<prompt> Which is true regarding IL-1?Mainly derived from neutrophilsProduces necrosis of tumor cellsIncreases expression of MHC coded proteinsUpregulates adhesion molecules  <response>: Produced by tissue macrophages, monocytes, fibroblasts and dendritic cells and also expressed by B cells, lymphocytes, NK cells and epithelial cells Increases the expression of adhesion factors on endothelial cells to enable transmigration Causes fever, hyperalgesia, vasodilation and hypotension 