<prompt> In patients with Chronic Myeloid LeukemiaABL gene on Chr. 22 is trans-located to BCR gene on Chr.9The fusion gene bcr-abl forms a protein with tyrosine kinase activitySplenomegaly is unusualPhiladelphia chromosome positive patients respond poorly to Imatinib  <response>: Ans. b The fusion gene bcr-abl forms a protein with tyrosine kinase activityRef: Robbins 9thpg 616-618a. FALSE, as ABL gene is on chr9q while BCR is on chr22qb. The fusion gene bcr-abl forms a protein with tyrosine kinase activity: TRUEc. FALSE; Massive splenomegaly is a feature of CMLd. FALSE; as response to Imatinib is good in patients with Philadelphia chromosome ve 