<prompt> Osteoblastic secondaries in spine seen withCarcinoma prostateCarcinoma thyroidEndometrial carcinomaCarcinoma rectum  <response>: i.e. Carcinoma prostate: 613-H17th CSDT 13th Most common cause of osteoblastic secondariesIn males - Prostate cancersIn females - Breast cancer Most common cause of osteolytic metastasisIn males - Lung cancersIn females - Breast cancers Lytic expansile metastasis - Thyroid, Renal Carcinomai Peripheral zone is site for Adenocarcinoma PACii Transition periurethral is site for BPHAlthough some tumours may produce mainly osteolytic lesions eg Kidney cancers and other mainly osteoblastic lesions eg prostate cancers most lesions produces both types of lesion and may go through stages where one or the other predominates 613-H17th 