<prompt> Which of the following conditions is due to membrane receptor defect?Beta thalassemiaFamilial hypercholesterolemiaHSPSickle cell disease  <response>: Ans: B Familial hypercholesterolemia Ref: Robbins Pathologic Basis of Disease, 8th editionExplanation:Familial hypercholesterolemiaPathology: Mutations in the LDLR gene that encodes the LDL receptor protein, which normally removes LDL from the circulation, or apolipoprotein B Apob, which is the part of LDL that hinds with the receptor. See Table 9 