<prompt> Which among the following is the most frequent manifestation of MEN 1?Parathyroid hyperplasiaPituitary adenomaAdrenal adenomaBronchial carcinoids  <response>: MEN 1 is an autosomal dominant disorder due to a defect in 11q13, which encodes for a 610-amino-acid nuclear protein, menin. Patients with MEN1 develop hyperparathyroidism due to parathyroid hyperplasia in 95-100 of cases, pituitary adenomas in 54-80, adrenal adenomas in 27-36, bronchial carcinoids in 8. Ref: Harrisons Principles of Internal Medicine, 18th Edition, Page 3060. 