<prompt> Increased alkaline phosphatase is seen in -OsteoporosisMultiple myelomaPagets diseaseOsteolytic metastasis  <response>: Ans. is c i.e., Pagets disease o Whenever the activity of osteoblasts increase, serum alkaline phosphatase is raised. Therefore, serum alkaline phosphatase acts as an index of osteoblastic activity.o The conditions in which osteoblastic activity is increased and hence the alkaline phosphatase in increased are : -i Ricketsosteomalaciav Pagets disease osteitis deformansii Primary hyperparathyroidismvi Osteoblastic secondariesiii Renal osteodystrophy secondary hyperparathyroidism iv Chronic renal failure and secondary hyperparathyroidism 