<prompt> Resistance to drugs in Tuberculosis develops by -TransductionConjugutionTransformationMutation  <response>: Ans. is d i.e., Mutation o The most common mechanism of antitubercular drugs resistance is by mutation - INH -- Catalase - peroxidase gene Kat G or inh A gene. Rifampin -- rpo B gene PZA -- pnc A gene ETB -- emb B gene Streptomycin -- 16 S rRNA gene rrs or ribosomal protein S-12 gene rpst. 