<prompt> A 10-year-old boy with a history of recurrent bacterial infections presents with fever and a productive cough. Biochemical analysis of his neutrophils demonstrates defective oxidative burst. This patient most likely has inherited mutations in the gene that encodes which of the following proteins?CatalaseCytochrome P450MyeloperoxidaseNADPH oxidase  <response>: The impoance of oxygen-dependent mechanisms in the bacterial killing by phagocytic cells is exemplified in chronic granulomatous disease CGD. Children with this disease suffer from a hereditary deficiency of NADPH oxidase which leads to decreased oxidative burst. Susceptible to recurrent bacterial infections. The most common variants are an X-linked defect in one of the membrane-bound components gp91phox and autosomal recessive defects in the genes encoding two of the cytoplasmic components p47phox and p67phox. -Patients deficient in myeloperoxidase choice C cannot produce hypochlorous acid HOCl and experience an increased susceptibility to infections with the fungal pathogen Candida. -Catalase choice A conves hydrogen peroxide to water and molecular oxygen. Diagnosis: Chronic granulomatous disease 