<prompt> Which drug can be eliminated by nonenzymatic degradation -AtracurimPancuroniumMivacuriumDexacurium  <response>: Ans. is a i.e., Atracurium o The unique feature of atracurium is inactivation in plasma by spontaneous nonenzymatic degradation Hofman elimination in addition to that by alkaline ester hydrolysis o Consequently its duration of action is not altered in patients with hepaticrenal insufficiency or hypodynamic circulation - Preferred muscle relaxant for such patients as well as for neonates and the elderly o Atracurium is metabolised to laudanosine that is responsible for seizures. 