<prompt> Which of the following is the major site of erythropoietin production during the fetal stage:LiverYolkBoneSpleen  <response>: a. LiverRef: Nelsons 20e p 2306Erythropoietin EPO is produced in fetal liver during 1st 2nd trimesters, by cells of monocytemacrophage origin.After birth, the anatomic site of EPO production shifts to the kidney. 