<prompt> Hormone Replacement TherapyH in postmenopausal women is beneficial in all these ExceptVasomotor symptomsOsteoporosisPrevention of CADVaginal atrophy  <response>: Hormone Replacement TherapyEstrogen is the most effective treatment available for relief of the menopausal symptoms that many women experience, including hot flashes, vaginal dryness, urinary symptoms, and emotional lability.Women;s Health Initiative showed no cardiovascular benefit with unopposed estrogen and a smallincrease in risk with combined therapy.Estrogen is an option for the prevention of osteoporosis inperimenopausal women, estrogen-progesterone therapy reduces fracture risk at a cost of increase in the incidence of breast cancer, coronary hea disease, stroke and venous thromboembolism, or in the case unopposed estrogen, an increase in stroke and thromboembolism.Post-menopausal hormone therapy, either unopposed estrogen or combined estrogen-progestin therapy should not be initiated for prevention of CHD.Bisphosphonates or raloxifene are recommended as first-line drugs for prevention and bisphosphonates for treatment of established osteoporosis.Refer: Novaks Textbook of Gynaecology, 14th edition, pg no- 1330-1333 