<prompt> Which of the following is recommended for culture sampling in Infective Endocarditis:2 culture sets separated by at-least 1 hour over 24 hours2 culture sets separated by at-least 2 hours over 24 hours3 culture sets separated by at-least 1 hour over 24 hours3 culture sets separated by at-least 2 hours over 24 hours  <response>: Answer is C 3 culture sets separated by at-least 1 hour over 24 hours Three culture sets separated from one another by at-least I hour should he obtained over 24 hours. in the absence of prior antibiotic therapy three 2-bottled culture sets separated from one another by at-least 1 hour should be obtained from different venepuncture sites over 24 hours. If the cultures remain negative 48 to 72 hours, two or three additional blood culture sets should be obtained 