<prompt> Children with Thalassemia and Iron overload are at an increased risk for infection with?Yersinia EnterocoliticaCampylobacter jejuniEscherichia coliVibrio cholera  <response>: - Iron therapy may increase the virulence of malaria and ceain, gram-negative bacteria, paicularly in developing countries. - Iron overload is associated with Yersinia infection. EXTRA EDGE: - Iron overload is treated by iron chelation therapy - IRON CHELATION THERAPY: Usually staed when serum ferritin 1000 ngml Deferoxamine - Parenterally IV or SC - Effective in reveing hepatic cardiac iron deposition. Deferiprone - 1st oral chelator. - Adverse effects - Agranulocytosis, GI side effects, ahritis Deferasirox - Oral drug, Effective in decreasing cardiac iron burden lowering serum ferritin. 