<prompt> Drug distribution is inversely propoional toPlasma protein bindingLipid Solubilityfat layer in the bodystructure of drug  <response>: The extent of distribution of a drug depends on its lipid solubility, ionization at physiological pH, the extent of binding to plasma and tissue proteins, differences in regional blood flow. If PPB is high VD is low, PPB is inversly propoional to vd drugs with low vd usually have high ppb ref; KD Tripathi pharmacology 6th edition page no;18 