<prompt> Endemic cretinism is seen when iodine uptake is less than5microgramday20microgramday50microgramday75microgramday  <response>: Endemic cretinism is seen when iodine uptake is less than 20microgramdayEndemic cretinism is the extreme clinical manifestation of severe hypothyroidism during foetal, neonatal and childhood stages of development. It is characterised by severe and irreversible mental retardation, sho stature, deaf-mutism, spastic dysplegia and squints.Cretinism seen in severe endemic areas is predominantly of two types a neurological cretinism, where the neurological manifestations of thyroxin deficiency early in life, i.e. hypothyroidism, were confined to the in-utero or neonatal stages. b Myxedematous cretinism, where besides having mental retardation, sufferers also have myxoedema and dwarfism.Associated with goitre when iodine uptake is less than 50microgramday. Normal requirement is 150microgramday 