<prompt> What is the treatment of choice for cystosarcoma phylloides?Wide local excisionRadical mastectomyRadiotherapyChemotherapy  <response>: Cystosarcoma phylloides are not simply giant fibroadenoma. They show a wide spectrum of activity, varying from almost a benign condition 85 to a locally aggressive and sometimes metastatic tumour 15. Depending on mitotic index and degree of pleomorphism they are graded as low grade to high grade tumours. When malignant sarcoma spreads to lungs or bone. Treatment is wide local excision or subcutaneous mastectomy is done. If malignant sarcoma, total mastectomy is indicated. Ref; page no; 520 5th edition of SRB;S manual of Surgery 