<prompt> The earlies antibody marker to appear In the serum in Hepatitis B virus infection Is-Anti-HBsAnti-HBeAnti-HBcAnti-Hbx  <response>: Davidson;s principles and practice of medicine 22nd edition. HBc Ag is not found in blood but antibody to it appeared early in the illness incubation period and rapidly reached a high titre which subsides gradually but then persist. 