<prompt> Antibodies associated with GTCS in SLE :Anti neuronal abAnti-Ro abAnti-Sm abNone  <response>: Ans.A Anti neuronal ab Ref: Harrisons Internal medicine 18thTable 319-1; 17th edition, P. 2076. Autoantibodies in Systemic Lupus Erythematosus SLE Antibody Prevalence, Antigen Recognized Clinical Utility Antinuclear antibodies 98 Multiple nuclear Best screening test; repeated negative tests make SLE unlikely Anti-dsDNA 70 DNA double-stranded High titers are SLE-specific and in some patients correlate with disease activity, Anti-Sm 25 Protein complexed to 6 species of nuclear U1 RNA Specific for SLE; no definite clinical correlations; most patients also have anti Anti-RNP 40 Protein complexed to U1 RNA Not specific for SLE; high titers associated with syndromes that have overlap blacks than whites Anti-Ro SS-A 30 Protein complexed to hY RNA, primarily 60 kDa and 52 kDa Not specific for SLE; associated with sicca syndrome, predisposes to subacute cutaneous with decreased risk for nephritis Anti-La SS-B 10 47-kDa protein complexed to hY RNA Usually associated with anti-Ro; associated with decreased risk for nephritis Antihistone 70 Histones associated with DNA in the nucleosome, chromatin More frequent in drug-induced lupus than in SLE Antiphospholipid 50 Phospholipids, 2 glycoproteins 1 cofactor, prothrombin Three tests available ELISAs for cardiolipin and 2G1, sensitive prothrombin Antierythrocyte 60 Erythrocyte membrane Measured as direct Coombs test; a small proportion develops overt hemolysis Antiplatelet 30 Surface and altered cytoplasmic antigens on platelets Associated with thrombocytopenia but sensitivity and specificity are not good; Antineuronal includes anti-glutamate receptor 60 Neuronal and lymphocyte surface antigens In some series a positive test in CSF correlates with active CNS lupus. Antiribosomal P 20 Protein in ribosomes In some series a positive test in serum correlates with depression or psychosis Also remember: Antibody Best screening test for Antibody ANA SLE Anti-Histone Drug-induced lupus Antinuclear antibodies SLE, nonspecific Anti-dsDNA; Anti-Sm Specific for SLE Anti-sm Nelsons Paediatric Textbook Marker of CNS lupus Anti-DNA Level of which correlates with disease activity Anti-Ro SS-A SACL, neonatal lupus Anti-Ro and Anti-La ie risk of nephritis protective against nephritis Antiphospholipid Hematological and Fetal Loss Antiribosomal protein Depression and Psychosis Anti-basement membrane Goodpasture syndrome Anticardiolipin, lupus anticoagulant SLE, antiphospholipid syndrome Anticentromere Limited scleroderma CREST syndrome Anti--Scl--70 anti--DNA topoisomerase 1 Scleroderma diffuse Anti--SSA, anti--SSB anti-Ro, anti--La Sjogren syndrome Anti--Jo--1, anti--SRP, anti--Mi--2 Polymyositis, dermatomyositis Anti--TSH receptor Graves disease Anti--U1RNP ribonucleoprotein Mixed connective tissue disease c-ANCA PR3-ANCA Granulomatosis with polyangiitis Wegener IgA antiendomysial, IgA anti--tissue transglutaminase Celiac disease p-ANCA MPO--ANCA Microscopic polyangiitis, Churg--JStrauss syndrome Anti--ACh receptor Myasthenia gravis Rheumatoid factor antibody, most commonly IgM, specific to IgG Fc region, anti--CCP Rheumatoid arthritis Anti--glutamate decarboxylase Type 1 diabetes mellitus Anti--desmoglein Pemphigus vulgaris Anti--hemidesmosome Bullous pemphigoid Antimicrosomal, antithyroglobulin Hashimoto thyroiditis Antimitochondria! 1 biliary cirrhosis Anti--smooth muscle Autoimmune hepatitis ALSO KNOW: LE cells Neutrophils with LE bodies seen in SLE, RA Penicillamine drug induced Hematoxilin bodies SLE endocarditis Libmann-Sack Wire-loop lesions SLE type IV nephritis 