<prompt> Which of the following autoantibody is least likely associated with SLEAnti ds- DNAAnti SmAnti topoisomeraseAnti histone  <response>: Ref Robbins 9e p219 Anti topoisomerase is least commonly associated with SLE amongst the given options .The following is a modified table for a reference from Robbins Autoantibody Specificity Major Disease Associations Likely Roles in Disease Anti-dsDNA double-stranded DNA SLE Formation of immune complexes Anti-Sm ribonuclear core protein, Sm antigen SLE Formation of immune complexes Anti-RNP U1 ribonuclear protein SLE, mixed connective tissue disease Formation of immune complexes Anti-SS-A Ro, anti-SS-B La ribonucleoproteins Sjogren syndrome, SLE Role in Sjogren syndrome not known Anti-Scl-70 DNA topoisomerase I Systemic sclerosis Unknown Anti-histones histone proteins SLE Formation of immune complexes Anti-centromere centromere proteins Limited scleroderma, systemic sclerosis Unknown Antiphospholipid phospholipid-protein complexes involved in blood coagulation Antiphospholipid syndrome, SLE Thrombotic episodes Anti-Jo1 histidyl tRNA ligase Inflammatory myopathies Unknown Anti-mitochondrial Primary biliary cirrhosis Unknown Anti-eTg transglutaminase Dermatitis herpetiformis Unknown Anti-neutrophil cytoplasmic antibody ANCA proteins in neutrophil cytoplasm Various vasculitides Formation of immune complexes? Neutrophil degranulation? Anti-smooth muscle Chronic autoimmune hepatitis Unknown 