<prompt> Drug X is normally administered to patients at a rate of 50 mghour. Elimination of the drug X from body takes place as: - Hepatic Metabolism 10 - Biliary Secretion 10 - Renal Excretion 80 This drug has to be administered to a 65 years old patient Uttaam Singh, with a GFR of 60 mlmin. assuming normal GFR is 120mlmin. Liver and biliary functions are normal in this patient. What should be the dose rate of drug X in this patient?50 mghour30 mghr25 mghr100 mghr.  <response>: In this question 80 percent of drug is eliminated by renal route and 20 percent by non-renal routes 10 percent by hepatic metabolism and 10 percent by biliary secretion. This patient has 50 percent renal function 60 mlmin of GFR instead of 120 mlmin. Thus, the drug that can be eliminated in this person is 20 percent Non-renal route 40 percent Renal route; 50 percent of 80 percent 60 percent Thus, the dose rate should be 60 percent of the original. i.e. 50 mghr x 60 percent 30 mghr. 