<prompt> In renal disease albumin is first to appear in urine becauseOf its high concentration in plasmaHas molecular weight slightly greater than the molecules normally getting filteredHigh albumin : globulin ratioTubular epithelial cells are sensitive to albumin  <response>: Ans. b Has molecular weight slightly greater than the molecules normally getting filteredRef: Ganong, 25th edp.677Glomerular membrane permits neutral substances up to 4 nm in diameter. Substances greater than 8nm diameter are totally excludedAlbumin size is 7 nm. So, it has molecular weight slightly greater than the molecules normally getting filtered 