<prompt> In retinoblastoma, after enucleation, which tissue is sectioned to find out systemic metastasisCentral retinal aerySclera and episcleraOptic nerveVoex vein  <response>: C i.e. Optic nerve Enucleation is indicated in large retinoblastoma with diffuse involvement due to poor prognosis high risk of recurrence normal fellow eye so aggressive chemotherapy is inappropriate. It should be done with minimal-manipulation and it is imperative to obtain 8-12 mm piece of optic nerve Q to rule out any spread of tumor to brain. 