<prompt> Acetaminophen poisoning causes which of the following changes in the liver?Centrilobular necrosis in liverMicrovesicular fatty infiltration in hepatocytesCholestasisPeripoal inflammation  <response>: Acetaminophen poisoning typically causes centrilobular necrosis in liver. Ref: Harrisons Principles of Internal Medicine, 18th Edition, Page 2560, see Table: 305-1. 