<prompt> In a case controlled study, it is found that the disease is more common in the group taking coffee as compared to the control group. The significance of this is:Cause and effect relationship establishedDisease median can be calculatedCaffeine is associated with occurrence of diseaseControls will not get the disease  <response>: Ans is c i.e. Caffeine is associated with the occurrence of the diseases Ref: Park 20e, p 69 18e, p 68, 17e p64, 16e,p62Cause and effect relationship is not established by case control study. It can be established by cohort study. A case control study cannot distinguish between causal factors and associated factors.A case control study can measure only the odd ratio an estimate of relative riskA case control study does not establish a cause and effect relationship but it definately tells that caffeine is associated with the disease under study. 