<prompt> Patients with hemophilia A has bleeding disorder because of-Lack of platelet aggregationLack of reaction accelerator during activation of factor X in coagulation cascadeNeutralization of antithrombin IIIRelease of Thromboxane A2  <response>: Haemophilia is caused by quantitative reduction of factor VIII in 90 of cases well 10 cases have normal or increased level of factor VIII with reduced activity. factor VIII activates factor X the blood coagulation pathway. But in haemophilia A due to reduced activity of factor VIII ,It can not activate factor X.Therefore , no coagulation exists and increases bleeding. Reference: textbook of Pathology ,7th edition ,author Harsha Mohan, page number 313 