<prompt> Frame shift mutation:Substitution of amino acidChanged mRNA base at 3rd nucleotide of codonDue to stop codonDeletion of 2 bases  <response>: Ans. d Deletion of 2 basesRef: Harpers Biochemistry, 30th ed. pg. 417-18 Somatic Mutation Include Point mutation- mutation of single nucleotide Silent mutation: If the changed base in the mRNA molecule at the third nucleotide of a codon, leads to no detectable effect. Mis-sense mutation: Substitution of amino acid Non sense mutation: Appearance of stop codon due to mutation Frame shift mutation-due to deletioninsertion, of one or two bases, which causes shift in reading frame. Whole reading frame is changed leading to entirely different protein molecule synthesis, called garbled protein. Trinucleotide repeat mutation-repeat more than 55 times. 