<prompt> Characteristic of Systemic Juvenile Idiopathic Arthritis -Begins after 16 years of ageUveitis is a featureRA factor is negativeNSAIDS are contraindicated  <response>: Ans. is c i.e., RA factor is negative JRA is the most common type of Juvenile idiopathic arthritis, thus, most often JRA is used as a synonym for juvenile idiopathic arthritis. JRA is a group of chronic inflammatory joint disorder characterized by :i Arthritis of one or more jointsii Onset before 16 yearsiii Persisting for 6 weaksiv Exclusion of other causes of arthritis. JRA can be classified into following typesA Pauciarticular oligoarticular JRA It is characterized by involvement of four or fewer joints. It is the most common type of JRA. Joint involvement is assymetrical. There are two subtypesi Type 1 It is characterized by eye involvment with iridocyclitis, glaucoma, cataract. It is associated with HLA - DR5 and DRW8. Antinuclear antibody ANA is positive but rheumatoid factor RF is negative.ii Type II It is characterized by self limiting iritis not iridocyclitis and is associated with HLA-B27. Both ANA and RF are negative.B Polyarticular JRA It is characterized by involvement of 5 or more joints. There are two subtypesi Polyarticular RA positive It is characterized by symmetrical joint involvement along with Uveitis, and rheumatoid nodules. RA factor and ANA are positive.ii Polyarticular RA negative RA factor and rheumatoid nodules are not seen.C Systemic JRA It is characterized by systemic features like fever with rash, lymphadenopathy, and hepatosplenomegaly. There is neutrophilic leukocytosis with raised ESR. ANA may be positive, but RA factor is negative. Uveitis iridocyclitis is characteristically asent. Initial drug of choice for JRA is one of the NSAIDs. NSAIDs commonly used in children are Naproxen, Ibuprofen, Aspirin and Indomethacin. 