<prompt> Contraindication for PA in ischemic stroke isClinical diagnosis of strokeSystolic BP 180 mm of HgComatose patientOnset of symptoms 4.5 hours  <response>: Contraindications for administration of Intravenous Recombinant Tissue Plasminogen Activator PA for Acute Ischemic Stroke AISSustained BP 185110 mmHg despite treatmentPlatelets 100,000; HCT 25; glucose 50 or 400 mgdLUse of heparin within 48 h and prolonged PTT, or elevated INRRapidly improving symptomsPrior stroke or head injury within3 months; prior intracranial haemorrhageMajor surgery in preceding 14 daysMinor stroke symptomsGastrointestinal bleeding in preceding21 daysRecent myocardial infarctionComa or stuporRef: Harrison 19e pg: 2562 