<prompt> Characteristic skin lesion in Peutz -Jeghers syndrome isFrecklesLentigensAdenoma sebaceumCafe -au- lait macules  <response>: Peutz Jegher syndrome. Peutz-Jeghers syndrome- Autosomal dominant - Lentigens increased melanocytes leading to hyperpigmented macules - Site of lentigen - Periorallips,Buccal mucosa - Associated with GI polyp. MC : Jejunal hamaomaFreckles ephelides It is increased localized melanogenesis. Normally seen in fairer skin colour Skin type I,II Become dark on sun exposure Adenoma Sebaceum is seen in Tuberous sclerosis aka epiloia Cafe au lait macules is seen in Neurofibromatosis dark color lesion over lighter skin. 