<prompt> Alpha-1 antitrypsin acts to prevent lung tissue destruction byInhibiting the release of trypsinInhibiting the activation of trypsinogenInhibiting the release of chymotrypsinInhibiting the elastase of neutrophils in lung  <response>: Answer- D. Inhibiting the elastase of neutrophils in lungThe most accepted theory in the pathogenesis of emphysema is protease - antiprotease mechanism which is responsible in the pathogenesis of two common forms of emphysema, i.e. centriacinar and panacinar.A Pathogenesis of panacinar emphysemaPanacinar emphysema is associated wlth congenital deficiency of alpha 1-antitrypsin.Neutrophil are the major cell in the pathogenesis of panacinar emphysema.B Pathogenesis of centriaginar emphysema in centriacinar emphysema, both neutrophils and macrophages play central role. 