<prompt> Commonest carcinoma of the with multifocal origin isSchirrhous carcinomaAdenocystic carcinomaLobular carcinomaDuctal carcinoma  <response>: Refer Robbins page no 1057 DCIS can be divided into two major architectural subtypes, comedo and noncomedo Fig. 23-17. Some cases of DCIS have a single growth pattern, but most are comprised of a mixture of patterns. Nuclear grade and necrosis are better predictors of local recurrence and progression to invasion than architectural type. Comedo DCIS may occasionally produce vague nodularity, but more often it is detected on mammography as clustered or linear and branching areas of calcification Fig. 23-17A. It is defined by two features: 1 tumor cells with pleomorphic, high- grade nuclei and 2 areas of central necrosis Fig. 23-17B. Noncomedo DCIS lacks either high-grade nuclei or central necrosis. Several patterns may be seen. Cribriform DCIS may have rounded cookie cutter-like spaces Fig. 23-17C within the ducts, or a solid DCIS pattern. Micropapillary DCIS pro- duces bulbous protrusions without a fibrovascular core, often arranged in complex intraductal patterns Fig. 23-17D. In other cases, DCIS produces true papillae with fibrovascular cores that lack a myoepithelial cell layer. Calcifications may also be seen in noncomedo forms of DCIS in association with focal necrosis or intraluminal secretions. 