<prompt> Drug distribution is influenced by:Plasma protein bindingLipid solubilityDegree of blood flowAll of these  <response>: - Factors affecting drug distribution Lipid solubility - Higher the solubility, higher the distribution Ionization at physiological pH - Higher the ionization, lower the distributionThe degree of plasma protein binding - More the binding, less the distribution Affinity for different tissues - Higher affinity, higher distribution Regional blood flow - More the flow, more the distribution Fat: lean body mass ratio changes with age - Increases with age Disease like CHF, uremia, cirrhosis 