<prompt> Which of the following drugs can produce dramatic improvement in patients with Type II lepra reaction?ThalidomideSteroidsDapsoneClofazamine  <response>: Ans. a Thalidomide. Ref. Harrison, Internal Medicine, 15th ed., 1038Treatment of Type I Lepra reactionTreatment of Type II Lepra reaction Best with corticosteroids. Thalidomide ineffective in Typel reaction and clofazimine questionable. In mild reaction give antipyretics Then glucocorticoids Thalidomide causes dramatic improvement probably attributable to its reduction of TNF levels and IgM synthesis and slowing of PMN migration. 