<prompt> Anaphylactic reaction caused by NSAIDs, all are true, except ?Caused by All NSAIDsCOX-2 inhibitors are safeRelated to hypersensitivity reactionNot related to inhibition of COX  <response>: Ans. is b i.e., COX-2 inhibitors are safeRef: Clinical pharmacology 3de p.786Anaphylactic reaction anaphylaxisIt is dre to immediate type-L hypersensitivity involving cross linking of drug-specific IgE.Regardless of COX selectivity pattern, NSAIDs may function as haptens capable of inducing allergic sensitization.Thus, all COX inhibitors nonselective or selective can cause this reaction. 