<prompt> True statements regarding vancomycin uses are all of the following except: September 2009Surgical prophylaxis in MRSA prevalent areasDrug of choice for pseudomembranous enterocolitisEffective in penicillin-resistant pneumococcal infectionMethicillin-resistant Staphylococcus aureus infection  <response>: Ans. B: Drug of choice for pseudomembranous enterocolitis Vancomycin is used in Proven methicillin-resistant MR Staph. aureus S.A. or coagulase-negative Staphylococcal infections Serious infections where coagulase-negative Staphylococci is highly suspected e.g., central line, prosthesis, sternotomy, etc. Endocarditis caused by methicillin-resistant Staphylococci plus gentamicin and rifampin for prosthetic valve endocarditis caused by coagulase-negative Staphylococci. Meningitis caused by flavobacteria or Penicillin-resistant pneumococcus plus cefotaxime CNS shunt infection caused by methicillin resistant Staphylococci rifampin Infections caused by organisms susceptible only to vancomycin e.g., Corynebacterium jeikium Ampicillin-resistant enterococcal infections. Prophylaxis for major surgical procedures for implantation of prosthetic materials or devices at hospitals with a high rate of infections due to methicillin-resistant Staphylococci. A single dose administered immediately before surgery is sufficient unless the procedure lasts more than 6 hours, in which case the dose should be repeated. Prophylaxis should be discontinued after a maximum of two doses. It is second choice drug to metronidazole for antibiotic associated pseudomembranous enterocolitis caused by C.difficile. 