<prompt> Calcification in necrotic tissue is called -Dystrophic calcificationMetastatic calcificationCalcinosisTumoral calcicosis  <response>: Amyloidosis is the extracellular deposition of insoluble protein fibrils.AL- Primary systemic amyloidosisAA- Secondary amyloidosisAF- FamilialAβ2M- In ESRDDiagnosed by abdominal fat pad aspiration showing apple green birefringence by polarized light microscopy with Congo red stainHigh ESR, High ALPSerum Immunofixation electrophoresis SIFE, UIFE-sensitive to detect light chains Lamda more commonKidneys- most common involved. Nephrotic range proteinuria, azotemia seen Heart- second common organ; restrictive cardiomyopathy, low voltage complexes in ECG, sparkly appearance on ECHO heartPeripheral sensory neuropathy, carpal tunnel syndromeLarge tongue, raccoon-eye sign-Factor X deficiency bleedingTreatment- AL- Melphalan. dexamethasone, lenalidomide bortezomib;HDMSCT- Autologous stem cell transplantation after high-dose melphalanHigh BNP. pro-BNP, troponin T I in cardiac involvement, used for prognosis too.AA Amyloidosis: secondary to chronic infections - tuberculosis, SABE or inflammatory conditions like RA, IBD, Castlemans diseaseTreat the primary disease, TNF IL -1 antagonist.The new drug - Eprodisate for renal AAAF Amyloidosis: AD, mutant TTR transthyretinprealbumin Peripheral autonomic neuropathy Cardiac conduction defects Aβ2M Amyloidosis: associated with ESRD. on hemodialysisCarpal tunnel syndrome, joint effusions, cystic bone lesionsDecreases with stopping dialysis 