<prompt> Fixed drug combination have all advantages except ?Increased complianceDecreased incidence of drug resistanceNo dose adjustment in combination preparationsSynergistic effect of some drug combinations  <response>: Ans. is c i.e., No dose adjustment in combination preparation. FDCs offer simple dosage schedule which improves patient compliance and therefore improves treatment outcomes. Impoant in elderly patients or patients suffering from multiple disorders. More economic than single ingredient drugs. Such reduced pill burden can greatly enhance the overall treatment outcome. 