<prompt> MetoclopramideInhibit cholinergic smooth muscle stimulation in the gastrointestinal tractDecrease lower esophageal sphincter pressureStimulate D2 receptorNo significant action on colonic motility  <response>: metoclopramide incerase peristalsis ,no significant action on colonic motility ESSENTIALS OF MEDICAL PHARMACOLOGY SEVENTH EDITION KD TRIPARHI PG NO.664 