<prompt> What is mechanism of action of curonium drugs as muscle relaxant?Persistently depolarizing at neuromuscular junctionAct competitively on Ach receptors blocking postsynapticallyRepetitive stimulation of Ach receptors on muscle end plateInhibiting the calcium channels on presynaptic membrane  <response>: Persistently depolarizing at neuromuscular junction - propey of succinylcholine depolarising eg : succinylcholine 1. MOA - persistent prolonged depolarising of nicotinic cholinergic receptors 2. fasiculation seen 3. post operative myalgia 4. not reversed by neostigmine 5. train of four response not seen 6. TOF ratio BA 1 7. neuromuscular monitoring not done 8. no post tetanic facilitation non - depolarising 1. MOA - competitive antagonist 2. fasiculation not seen 3. no post operative myalgia 4. reversed by neostigmine 5. train of four response seen 6. TOF ratio BA 1 7. neuromuscular monitoring done 8. post tetanic facilitation seen 