<prompt> metaclopromide:inhibit cholinergic smooth.muscle stimulation in the gastrointestinal tractdecrease lower esophageal spinchter pressurestimulate D2 receptorenhance colonic activity  <response>: metaclopromide is aD2 receptor antagonist that increases cholinergic activity by inhibiting presynapyic D2 receptors in GIT . it increases LES tone that is also responsible for anti emetic action. it does not significantly increase colonic motility 