<prompt> Most effective HDL raising drug is:Omega three fatty acidsNiacinFenofibrateRosuvastatin  <response>: Niacin is the most effective HDL raising drug currently available. Niacin is the only drug currently available that lowers Lipoproteinpa, and can be considered as an addition to a statin in patient with elevated Lpa. Statins have a modest HDL-raising effect 5-10. Fibrates are the most effective drugs available for reducing triglyceride levels and also raise HDL-C levels modestly. Omega three fatty acids are also effective in raise HDL level. Ref: Harrisons principles of internal medicine, 18th edition, Page: 3161 