<prompt> Which of these genes promote epithelial-mesenchymal transition and are important metastatic genes in epithelial tumors?MYCSNAILTWISTBoth 2 and 3  <response>: Metasis oncogenes are SNAIL and TWIST, which encode transcription factors whose primary function is to promote epithelial-to-mesenchymal transition EMT. In EMT, carcinoma cells downregulate certain epithelial markers e.g., E-cadherin and upregulate certain mesenchymal markers e.g., vimentin, smooth muscle actin.EMT has been documented mainly in breast carcinoma.Reference-Robbins BASIC PATHOLOGY 10th edition pg-223 