<prompt> Osteogenesis imperfecta is due toDefective synthesis of type I collagenGrowth hormone dysfunctionInborn error of the methionine metabolismBoney abnormality confined to the metaphysis  <response>: Defective synthesis of type I collagen 153-55-AOsteogenesis Imperfecta brittle bones 1:20,000It is basically a connective tissue disorder defective synthesis of type I collagen heterogenous disorders1. Osteopenia2. Propensity to fracture3. Laxity of ligaments4. Blue sclerae5. Crumbling teeth or dentinogenesisType I collagen Bone, ligament, tendon and skinType II collagen CartilageType III collagen Blood vessels, muscle and skinHumocvstinuria - is in bom error of methionine metabolism 