<prompt> Which malignancy would occur in long-standing multinodular goitre?Papillary CarcinomaFollicular CarcinomaAnaplastic CarcinomaMedullary Carcinoma  <response>: The incidence of follicular carcinoma is high in endemic goitrous areas, with long-standing multinodular goitre, possibly owing to persistent TSH stimulation.Dominant or rapidly growing nodules, especially in longstanding goitres, should always be subjected to aspiration cytology. 