<prompt> In carcinoma breast, adjuvant radiotherapy is indicated after modified radical mastectomy in all of the following exceptER, PR hormone receptor negative tumourTumour size more than 5 cmPositive marginsMore than four positive axillary lymph nodes  <response>: .Radiotherapy in carcinoma breast Indications: Patient who undergo conservative breast surgery, breast is irradiated after surgery After total mastectomy, external irradiation is given to axilla. Patients with higher risk of local relapse after surgery: a. Invasive carcinoma. b. Extensive in situ carcinoma. c. Patients under 35 years. d. With multifocal disease. In bone secondaries, to palliate pain and swelling. If there is pathological fracture in the bone, internal fixation has to be done along with external irradiation. Inflammatory carcinoma of breast. In atrophic scirrhous carcinoma of breast, as a curative radiotherapy. As preoperative radiotherapy, to reduce the tumour size and downstage the tumour, so that the operability is better. More than 4 positive lymph nodes in the axilla, pectoral fascia involvement, positive surgical margins, extranodal spread or in patients with axillary status not knownnot assessed. ref:SRB;s manual of surgery,ed 3,pg no 485 