<prompt> Which of the following drug is used in SIADH?TolvapatanDesmopressinVwb factorTerlipressin  <response>: Ans. A. TolvaptanTolvaptan:Vasopressin antagonists.Orally active nonpeptide selective V2 receptor antagonist.Metabolized by CYP3A4 - Not given to patients receiving this isoenzyme inhibitor.Given once daily.t 12 : 6-8 hours.Actions:Increases free water clearance by kidney aquaretic.Corrects lower plasma Na levels.Uses:Useful for hyponatremia treatment.Hyponatremia caused by CHF, cirrhosis of liver or syndrome of inappropriate ADH secretion SIADH.Side effect:Thirst dry mouth most frequent.Fever, G.I. upset hyperglycaemia. 