<prompt> Niemann-Pick disease occurs due to a defect inCeramidaseSphinogomyelinasePhospholipase Cb - galactosidase  <response>: DiseaseEnzyme DeficiencyClinical SymptomsNiemann-Pick diseaseSphingomyelinaseEnlarged liver and spleen, mental retardation;fatal in early lifeRef: Harper;s Biochemistry; 30th edition; Chapter 24 Metabolism of Acylglycerols Sphingolipids 