<prompt> Perlecan is a:Sacolemmal proteinProteoglycanGlycoproteinIntegral protein  <response>: Perlecan is a multidomain heparan sulfate proteoglycan synthesized by both vascular endothelium and smooth muscle cells deposited in ECM extracellular matrix. Perlecan is a potent inhibitor of smooth muscle cell proliferation and is thus thought to help maintain vascular homeostasis. Perlecan can also promote growth factor fibroblast growth factor 2 activity and thus stimulate endothelial growth and re-generation. Ref: Textbook of Aging Skin by Miranda A. Farage, Kenneth W. Miller, Howard I. Maibach, Page 116 