<prompt> Bisphosphonates act byIncreasing the osteoid formationIncreasing the mineralization of osteoidDecreasing the osteoclast mediated resorption of boneDecreasing the parathyroid hormone secretion  <response>: Bisphosphonates BPNs are analogues of pyrophosphate: carbon atom replacing oxygen in the P-0-P skeleton. They inhibit bone resorption by inhibiting osteoclast function- useful to prevent osteoporosis in addition to metabolic bone diseases and hypercalcaemia. REF.Essentials of Pharmacology TD TRIPATHI 6th EDITION page no 333 