<prompt> Earliest sign of rickets is ___CraniotabesHarrisons grooveRachitic rosaryPigeon breast  <response>: Most manifestations of rickets are a result of skeletal changes , Craniotabes is a softening of the cranial bones and can be detected by applying pressure at the occiput or over the parietal bones. T he sensation is similar to the feel of pressing into a ping-pong ball and then releasing. Craniotabes may also be secondary to osteogenesis imperfecta, hydrocephalus, and syphilis. Ref.nelson 20th edition page 339 nutrition chapter 