<prompt> Which of the following causes hemolytic anemia -a Hereditary spherocytosisb Infectionc Iron deficiencyd Sickle cell anemiae Copper deficiencyabdbcdabcab  <response>: Hemolytic anemia may be of two types. IntracorpuuscularUnderlying cause of hemolysis is intrinsic to RBC, e.g.,Defect in membrane cytoskeleton Hereditary spherocytosisDefect in red cell enzyme G6PD deficiency.Disorder of hemoglobin synthesis Deficient globin synthesis ThalassemiaStructurally abnormal globin Sickle cell anaemia.hemoglobinopathiesMembrane defect Paroxysmal nocturnal hemoglobinuria 2. ExtracorpuscularUnderlying cause of hemolysis is extrinsic, ie., not within RBC, e.g., : -Immunohemolytic anemiaMicroangiopathic hemolytic anemia i TTP, ii HUS, iii DICInfection MalariaMechanical trauma to RBC rosthetic valve.Hyperspienism 