<prompt> IP-3 facilitates the entry of which of the following ions into cytoplasm?NaKCa2Mg2  <response>: IP3 DAG: - Phospholipase catalyzes the breakdown of phospholipids in the cell membrane into two different second messenger products- IP3 DAG. IP3 mobilizes the calcium ion from mitochondria endoplasmic reticulum lumen to cytoplasm then the Ca ions have their own IInd messenger effects, such as smooth muscle contraction and changes in cell secretion. DAG the other lipid second messenger, activates the enzyme protein kinase C Release of Ca2 in smooth muscle contraction can be from: Influx from extracellular site through voltage or ligand gated Ca2channels in the plasma membrane Efflux from intracellular stores through a Ryr channel Efflux from intracellular stores through a IP3R Ca2 channel. 