<prompt> Which of the following inhalational agent should not be used in closed circuit?DesfluraneSevofluranceBoth 1 2Isoflurane  <response>: Sevoflurane, Trilene Methoxyflurane are avoided in closed circuit.Sevoflurane reacts with sodalime to produce compound A which is nephrotoxic.Trilene reacts with sodalime and produces phosgene gas and dichloroacetylene which can cause ARDS seizures respectively.Methoxyflurane can react with rubber tubing of closed circuit. 