<prompt> Which of the following is not true regarding super-antigens-Bind T cells irrespective of antigen specificity of TCRBind directly to both MHC II and T cell receptor causing T cell activationBind to cleft or antigen binding groove in the MHC H moleculeBinds directly to lateral aspect of T cell receptor  <response>: Reference :Robbins basic pathology 9th edition pg 110:An additional group of secreted bacterial proteins called superantigens also cause a syndrome similar to septic shock e.g., toxic shock syndrome. Superantigens are polyclonal T-lymphocyte activators that induce T cells to release high levels of cytokines, which in turn results in a variety of clinical manifestations, ranging from a diffuse rash to vaso- dilation, hypotension, and death. 