<prompt> Regarding aprepitant all are true execpt:Agonist at NK1 receptorsCrosses blood brain barrierAmeliorate nausea and vomiting induced by chemotherapyMetabolized by CYP450 enzymes  <response>: Aprepitant is a highly selective NK1 receptor antagonist orally active and enter the brain. It is used in treating and preventing chemotherapy induced emesis. It is metabolized by CYP3A4 enzymes and can also inhibit the metabolism of drugs metabolized by this enzyme e.g.warfarin.Katzung 11e p 1086,Goodman and Gilman 11ep650 