<prompt> Chromophobe variant of Renal cell carcinoma is associated with :VHL gene mutationsTrisomy of 7 and 17 7, 173 p deletions 3p-Monosomy of 1 and Y -1, -Y  <response>: Answer is D Monosomy of 1 and y: Chromophobe variants of renal cell carcinoma are charachterized by widespread extensive chromosomal losses resulting in monosomy or hypodiploid DNA index. This includes loss of chromosome 1 and V. The abnormalities most consistently observed have been multiple losses of whole chromosomes, most frequently 1, 2, 6, 10, 13, 17, 21 and the Y chromosome - Urological Surgical Pathology Classification of epithelial neoplasms arising from the kidney Carcinoma Type Cell of Origin Cytogenetics Clear cell Proximal tubule 3p deletions 3p-, VI IL gene mutations, 5q gains Papillary Proximal tubule Trisomy of chromosome 7 and 17 7, 17 Loss of Y chromosome -Y Chromophobe Coical collecting duct Hypodiploid Monosomy Loss of multiple chromosomes 1, 2, 6, 10, 13, 17. 21 Y Oncocytic Coical collecting duct Undetermined Either karyotypically normal or contain limited number of karyotypic abnormalities including -1, -Y and translocations involving chromosme II Collecting duct Medullary collecting duct Undetermined Losses of multiple chromosomes 1, 6, 14, 15 22 