<prompt> Serious complication of oral contraceptive is:Leg vein thrombosisHeadacheBreak through bleedingBreast tenderness  <response>: Leg vein thrombosis: Ref: 432-Park 20thVenous thrombo-embolism VITE: - The overall risk is to the extent of 4 - 6 times more than the non users. Pre- existing hypertension, diabetes, obesity and elderly over 35 years with smoking habits are of the important risk factor for OCP.CONTRAINDICATION OF COMBINED ORAL PILLSABSOLUTERELATIVEA Circulatory disease Past or presentB Disease of the liverC Others1 Obesity 2Varicosities 3Epilepsy 4 Bronchial asthma 5 Depression and fluctuation of the mood 6 Age over 35 years 7 Nurshing mothers in the first six months 8 Smoking 9 Gall bladder disease1. Arterior or venous thrombosis2. Severe hypertension3. Valvular heart disease Ischaemic heart disease4. Hyperlipidemia5. Focal migraine Active liver disease History of cholestatic jaundice in pregnancy Liver adenoma carcinoma Pregnancy Undiagnosed genital tract bleeding Estrogen dependent neoplasm eg breast cancer 