<prompt> Which of the following genes is not associated with Autosomal Dominant Tubulointerstitial Kidney Disease?MUC1HNF1bUMODNPHS2  <response>: Autosomal recessive FSGS results from mutations in the NPHS2 gene, which maps to chromosome 1q25-q31 and encodes the protein product podocin. Autosomal dominant tubulointerstitial kidney disease ADTKD: Previously known as medullary cystic kidney disease Variable presence of cysts, which often are not located in the medulla Now recognized to be due to following genetic mutations: MUC1 encodes mucin-1 expressed in distal nephrons UMOD encodes uromodulin expressed in thick ascending limb of loop of Henle REN encodes preprorenin expressed by juxtaglomerular apparatus HNF1b encodes hepatocyte nuclear factor 1b, a transcription factor that regulates multiple genes, including UMOD ADTKD is associated with non-specific clinical and pathologic findings and causes progressive renal failure in adult life The pathogenic mechanisms are unknown 