<prompt> All of the following are pyrogenic cytokines, except rpt Q28Interleuken 18 IL-18Interleuken 6 IL-6Tumor Necrosis Factor TNFInterferon a IFN-a  <response>: Refer Robbins 9e p75-76 inflammation and tissue repair IL-18 is a cytokine that belongs to the IL-1superfamily and is produced by macrophages and other cells. IL-18 works by binding to the interleukin-18 receptor, and together with IL-12, it induces cell-mediated immunity following infection with microbial products like lipopolysaccharide LPS. After stimulation with IL-18 in presence of IL-12, natural killer NK cells and ceain T cells release another impoant cytokine called interferon-g IFN-g or type II interferon that plays an impoant role in activating the macrophages or other cells. 