<prompt> Which of the following intermediates of TCA cycle is depleted in Type-I Diabetes mellitus to suppress TCA cycle?SuccinateMalatea-KetoglutarateOxaloacetate  <response>: Remember diabetic condition is similar to fastingstarvation catabolic state as body tissues does not get enough glucose. Hence gluconeogenesis and lipolysis is upregulated. TCA suppression in diabetes occurs due to following reasons: Oxaloacetate is used up for gluconeogenesis, which is not available for TCA. Excess lipolysis leads to increased beta oxidation of fatty acids which lead to the formation of excess NADH , which fuher depletes NAD. This suppresses TCA. Acetyl CoA is diveed to ketone body synthesis. 