<prompt> A condition which does not have granuloma?InfarctionTBSarcoidosisLeprosy  <response>: The dominant histological characteristic of infarction is ischaemic coagulative necrosis, except in the central nervous system where the feature is that of liquefactive necrosis.It will not lead to granuloma formation.Granuloma: Focus on chronic inflammation consisting of a microscopic aggregation of macrophages transformed into epithelium-like cells surrounded by a collar of mononuclear leucocytes, principally lymphocytes occasionally plasma cells.Types:Foreign body granuloma, eg. talc, suture Immature granuloma: insoluble particles especially microbes, eg. tubercle granuloma.Granulomatous inflammation:TB, leprosy, sarcoidosis, cat scratch disease, brucellosis, syphilis, LGV, berylliosis, some mycotic infections.Chemical mediators of DHS delayed hypersensitivity are:-IL2, IL3, TNF á, â, IFN by TH1 helper cellsThe chief mediator is IFN Remember: The most important inflammatory mediator TNF á TH2 helper cells secrete IL 3, 4, 5, 6, 10, 13 