<prompt> Orotic aciduria is due to deficiency ofDecarboxylaseTyrosinaseIsomeraseHomogentisate oxidase  <response>: Orotic aciduria an autosomal recessive disorder, can be caused by a deficiency in the enzyme UMPS, a bifunctional protein that includes the enzyme activities of orotate phosphoribosyltransferase and orotidine 5-phosphate decarboxylase. 