<prompt> Resistance to Zidovudine develops due toMutation at reverse transcriptaseIncreased efflux of the drug from inside the cellIncreased metabolism of drugDecreased Zidovudine 5 triphosphate formation  <response>: Zidovudine is a nucleoside reverse transcriptase inhibitors which is a viral enzyme .HIV undergoes mutations in this enzyme to become resistant to NIs Refer :KDT 6e p770 