<prompt> Negative pressure wound therapy NPWT is used in:Bedsore in sacrum after debridementAfter amputation negative suctionOsteomyelitisUnexplored fistulas  <response>: VACCUM ASSISTED CLOSURE NEGATIVE PRESSURE WOUND THERAPY NPWT NPWT Promotes wound healing by applying a vacuum through a special sealed dressing. Continued vacuum draws out the fluid from wound increases blood flow to the area. Vaccum may be applied continuosly or intermittently, depending upon the types of wound being treated clinical objectives. Negative pressure of -125 mm Hg is used Dressing should be changed 2-3 timesweek Primary Effects of NPWT on Wound Healing Macrodeformation Drawing the wound edges together leading to contraction Stablization of wound environment Wound protected from outside micro- organisms in a warm moist envirnoment Reduced edema With removal of soft tissue exudates Microdeformation Leading to cellular proliferation on the wound surface Contraindications for NPWT Use Malignancy in the wound Untreated osteomyelitis Non-enteric unexplored fistula Necrotic tissue with eschar 