<prompt> True regarding Sjogrens syndrome are all of the following except: September 2009Autoimmune conditionMales are commonly affectedProgressive destruction of lacrimal and salivary glandNo single laboratory investigation is pathognomic  <response>: Ans. B: Males are commonly affected SjOgrens Syndrome SS is a systemic autoimmune disease characterised by lymphocytic infiltration, acinar cell destruction and proliferation of duct epithelium in all salivary and larimal gland tissue. Extra glandular involvement of muscles, blood vessels, lungs, kidneys may also occur. Females are affected more than the males It may be primary and secondary when associated with other connective tissue diseases. There is a risk of progression to lymphoid malignancy. Dry mouth, dry eyes and ahritisahralgia are the 3 common presenting features. Of the extraaicular manifestations, Raynauds phenomena is the most common skin manifestation seen in 35 of patients. Vasculitis has been repoed in 5 of patients with Sjogrens syndrome. This includes small vessel leucocytoclastic vasculitis and medium vessel necrotising vasculitis. Distal A may be silent or lead to renal stones, nephrocalcinosis and compromised renal function. Hypergammaglobulinemia may be due to polyclonal activation of B cells. The diagnosis is base on the history as no single laboratory investigation is pathognomic of either primary or secondary Sjogrens syndrome 