<prompt> Patient was given chloroquine doxycycline for 7 days. Patients fever decreases in 4 days but, peripheral smear showed occasional gametocytes of plasmodium falciparum. This type of drug resistance is -R1 typeR2 typeR3 typeR4 type  <response>: Ans. is b i.e., R2 type WHO classification of antimalarial drug resistance 1. S-sensitive -- If a sexual parasites have cleared by day 6 from the begining of treatment wihout subsequent recrudescence until day 28. 2. R1-Low grade resistance -- Recrudescence of infection between 7-28 days of completing treatment. 3. R2-High grade resistance -- Reduction of parasitemia by more than 75 at 48 hours of completing treatment but failure to clear the organism within 7 days. 4. R3--Parasitemia does not fall by more than 75 within 48 hours of compleing treatment and there is no subsequent clearance of asexual parasites. Following information has been added in 22dege of Park Treatment o After treatment patient is considered cured it heshe does not have fever or parasitaemia till 28th day. Some patient may not respond to treatment especially in falciparum malaria, due to treatment failure : -I Early treatment failure ETF : - If any of the following occurs : - i Development of danger signs or severe malaria on day 1, 2 or 3, in the presence of parasitaemia. ii Parasitaemia on day 2 higher than day zero. iii Parasitaemia on day 3 with either i Axillary temperature 37.5degC or ii 25 count on day zero. 2 Late clinical failure LCF : - It includes : - i Development of danger signs or severe malaria with parasitaemia between day 4 and day 28. Presence of parasitaemia in 4-28 days with axillary temperature 37.5degC. 3 Late parasitological failure LPF: - Presence of parasitaemia between 7-28 days with axillary temperature 37.5degC. 