<prompt> Fluconazole differs from ketoconazole in that:It is not active by the oral routeIt is a more potent inhibitor of drug metabolismIt is not effective in cryptococcal meningitisIt is unlikely to produce anti-androgenic side effects  <response>: Fluconazole does not have anti-androgenic side effects. Ketoconazole is rarely used now a days because of several limitations like: Poor oral bioavailability Limited CNS penetration Powerful inhibition of microsomal enzymes Used in treatment of Cushing Syndrome Anti-androgenic adverse effects like gynaecomastia Fluconazole is preferred agent because it has: Very good oral absorption Maximum CNS penetration therefore effective in cryptococcal meningitis. No inhibitory action on microsomal enzymes No anti-androgenic propey. 