<prompt> Lesions of which of the hypothalamic nuclei cause diabetes insipidus:Dorsomedial nucleiSupraoptic and paraventricular nucleiMedian preoptic nucleiVentromedial nuclei  <response>: b. Supraoptic and paraventricular nucleiRef: Nelsons 20e p 348-349, Ghai 8e p 511Vasopressin, a 9-amino-acid peptide, has both antidiuretic and vascular pressor activity and is synthesized in the paraventricular and supraoptic nuclei of the hypothalamus.Deficiency of Vasopressin is responsible for Diabetes insipidus. 