<prompt> Neurofibrillary tangles are associated with:March 2007Bipolar disorderAlzheimers diseaseSchizophreniaMultiple infarctions  <response>: Ans. B: Alzheimers DiseaseNeurofibrillary tangles were first described by Alois Alzheimer in one of his patients suffering from the disorder now referred to as Alzheimers disease.Neurofibrillary tangles are pathological protein aggregates found within neurons in cases of Alzheimers disease. Tangles are formed by hyperphosphorylation of a microtubule-associated protein known as tau, causing it to aggregate in an insoluble form. These aggregations of hyperphosphorylated tau protein are also referred to as PHF, or Paired Helical Filaments.It is also believed that neurofibrillary tangles are seen in Creutzfeldt-Jakob disease.Neurofibrillary tangles are also found in Supranuclear palsy.Its also related to frontotemporal dementia however without detectable beta-amyloid plaques. 