<prompt> All of the following drugs are useful in destrussor instability EXCEPT:SolefenacinTolterodineFlavoxateDuloxetine  <response>: Ref:KD Tripathi pharmacology 7th edition page.no: 117,118, 462 Vesicoselective drugs are used for detrusor instability resulting in urinary frequency and urge incontinence. It selectively blocks M1M3 subtypes. Example are Oxybutynin, Tolterodine, Flavoxate, Darifenacin, Drotaverine, Solifenacin. Duloxetine is an SNRI. it is neither sedative nor anticholinergic, nor antihistaminic, nor a blocker 