<prompt> True fact regarding Crohns diseaseEntero enteric fistula is an indication for urgent surgeryMedical management includes antibiotics, immunosuppressive agents and biologic agentsNo increased risk for colonic cancerNo effect on feility  <response>: Crohns diseaseHLA - DR1 DQw5 and NOD genes, CD 4 T cells response Affects ileum but rectum sparedFull thickness - transmural involvement Skip lesions Non caseating granuloma Stricture Fistula Anal fissure Perianal abscess Discontinuous segmental asymmetrical colitis Normal vascular patternDiagnosis of Crohns diseaseTreatment of Crohns diseaseAssociated with Saccharomyces cerevisiae antibody Barium meal study - Cobblestone appearance; Rose thorn appearance; String sign of Kantor 5-ASAGlucocoicoidsAzathioprine and 6 Mercaptopurine or MethotrexateTNF alpha Therapy Infliximab; Adalimumab; CeolizumabCyclosporine or Tacrolimus or NatalizumabRefer: Sabistons Textbook of Surgery, 19th edition, pg no: 1244-1254 