<prompt> Anticentromere antibodies are most commonly associated with-Diffuse cutaneous systemic sclerosisMixed connective tissue diseaseCREST syndromePolymyositis  <response>: CREST syndrome, also known as the limited cutaneous form of systemic sclerosis lcSSc is a multisystem connective tissue disorder. The acronym CREST refers to the five main features: calcinosis, Raynauds phenomenon, esophageal dysmotility, sclerodactyly, and telangiectasia. It is associated with detectable antibodies against centromeres a component of the cell nucleus, and usually spares the kidneys a feature more common in the related condition systemic scleroderma. If the lungs are involved, it is usually in the form of pulmonary aerial hypeension. 