<prompt> Which of the following agent is a rho kinase inhibitor?FasudilRanolazineAmilorideNicorandi  <response>: Ans. A FasudilRef: Katzung 12the p206Rho kinase ROCK is a major downstream effector of the small GTPase RhoA. ROCK plays central roles in the organization of the actin cytoskeleton and is involved in a wide range of fundamental cellular functions such as contraction, adhesion, migration, proliferation and gene expression.Fasudil is an experimental drug that acts by inhibiting the rho kinase and is found to be effective in animal models for treatment of-Hypertension-Pulmonary Hypertension-Coronary artery disease-Diabetic cardiomyopathy-Vasospastic angina-Ischemic stroke-Heart failure-Erectile dysfunction-Cardiac remodeling 