<prompt> In minimal change disease following is not seen -Massive proteinuriaNormal electron microscopic appearanceLight microscopy normalGood response to steroids  <response>: B Normal electron microscopic appearance 650- Harshmohan 7thMinimal change disease 910-Rabbins pathologic of Basis of diseaseMost frequent clinical presentationNephritic syndrome selectiveproteinuriaPathogenesisUnknown; loss of glomerular polyanion podocyte injuryLight microscopyNormal; lipid in tubulesFluoroscence microscopyNegativeElectron microscopyLoss of foot processes, no depositsMINIMAL CHANGE DISEASE MEDRelatively benign disorder is characterized by uniform and diffuse effacement offoot processes of visceral epithelialcell podocyte, detectable only by electron microscopy in glomeruli that appear virtually normal by light microscopy.Most frequent cause of nephritic syndrome in children between 2 and 6 years. The disease sometimes follows a respiratory infection or routine prophylactic immunization.A characteristic feature its usually dramatic response to corticosteroid therapy.MCD in adults can be associated with Hodgkin lymphoma and less frequently other lymphomas and leukemias.In addition secondary MCD may follow NSAID therapy, usually in associated with acute interstitial nephritis.Hyper coagulation in Nephrotic syndrome is causes by loss of antithrombin III Most common fixative used in electron microscopy -formalinFixative used in histopathology - 10 buffered neutral formalin 