<prompt> Which of the following serum value is not in or of a diagnosis of PCOS?Elevated LHRise in oestroneestradiol levelReduced SHBG levelReduced serum fasting insulin level  <response>: The polycystic ovarian disease is a heterogeneous, multisystem endocrinopathy in women of reproductive age.Endocrinological changes are as follows:1. OestroneE2 level rises.2. LH level is raised over 10 IUmL. FSH level remains normal, but FSHLH ratio falls.3. SHBG level falls due to hyperandrogenism.4. Testosterone and epi-androstenedione levels rise.5. Fasting blood glucosefasting insulin, 4.5 suggests insulin resistance.6. Triglyceride level 150 mgdL-hyperlipidaemia HDL 50 mgdL. Testosterone 2 ngmL, free T 2.2 pgmL Normal level 0.2-0.8 ngmL. Normal androstenedione level is 1.3-1.5 ngmL. DHEA 700 ngmL suggests an adrenal tumor.7. Prolactin is mildly raised in 15 cases.8. Fasting insulin is more than 10 mIUL in PCOS in 50-70cases.9. Thyroid function tests may be abnormal hypothyroidism.10. 17-a-hydroxyprogesterone in the follicular phase 300 ngdL suggests adrenal hyperplasia due to 21-hydroxylase deficiency.11. Urinary coisol 50 mg24 h.Ref: Shaw;s textbook of gynecology; 16th edition; Page no: 432 