<prompt> Most commonly associated mutation in prostratic carcinoma is?p16INK4aPTENGPST 1APC  <response>: Harshmohan textbook of pathology 7th edition. prostatic carcinoma- at genetic level following epigenetic phenomenon and acquired somatic mutation have been repoed in development of prostatic carcinoma. 1. Epigenetic phenomenon- hyper methylation of GSTP 1 gene promoter causing loss of function of the gene that detoxifyes carcinogens. . 