<prompt> Major depression is thought to be caused by changes in:Histamine synapses in the Basal GangliaMonoamine synapses in the Basal GangliaGABA synapses in the CerebellumMonoamine synapses in the Limbic System  <response>: The limbic system is the emotional center of the brain. The monoamines, norepinephrine, serotonin, acetylcholine and dopamine have been implicated in depression. Histamine is not convincingly linked to any psychiatric illness. GABA gamma-aminobutyric acid is an inhibitory amino acid neurotransmitter mainly linked to schizophrenia and anxiety. The basal ganglia and cerebellum are involved in motor control. Ref: Waxman S.G. 2010. Chapter 19. The Limbic System. In S.G. Waxman Ed,Clinical Neuroanatomy, 26e. 