<prompt> The immunoglobulin most commonly involved in Multiple Myeloma is :IgGIgMIgAIgD  <response>: Answer is AIgG The M component in Multiple Myeloma can be made up of the immunoglobulins IgG, IgM, IgD, IgA, and IgE; light chains alone; or heavy chains alone. IgG Myeloma is the most common form of Multiple Myeloma while IgD 2 and IgE Rare are the least common. Distribution of immunoglobulin types in patients with multiple myeloma Type of protein Percentage IgG 52 IgA 22 IgM 12 IgD 2 IgE Rare 