<prompt> A farmer presented in OPD clinic with sweating, lacrimation, pin-point pupils. Possible poisoning with:Dhatura poisoningOrganophosphate poisoningAtropine poisoningCocaine poisoning  <response>: Ans. b Organophosphate poisoningRef Katzung Pharamacology 10th ed. Ch 7 In organophosphate poisoning, the organophosphate cholinesterase inhibitors are well absorbed from the skin, lung, gut, and conjunctiva--thereby making them dangerous to humans and highly effective as insecticides. These organophosphates irreversibly block acetylcholine esterase enzyme, thereby increasing the acetylcholine level. The patient therefore will present with cholinergic symptoms: Mn: SLUDGE Salivation, Lacrimation, increased urination, Diarreha, GI distress, Emesis DOC for this poisoning: ATROPINEAlso Know OXIMES Pralidoximes, Di-Acetyl monoxime are known as AchE enzyme reactivators. These are used only in organophosphate poisoning.Pin-point pupil is seen in poisoning with: Mn: POMP Pontine hemorrhage, Organophosphate, Morphine and Phenol poisoning 