<prompt> What is the probable diagnosis in a patient with a dilated pupil not responsive to 1 pilocarpineDiabetic third nerve palsyAdes pupilUncal HerniationPharmacological block  <response>: Refer Goodman and Gilman 12e 1777 Looking at the option one by one diabetic third nerve palsy: third Nerve Palsy due to any reason will result in mydriasis because oculomotor people milk supplies constrictor pupillae. As only one nerve is destroyed and but the receptors remain intact , so it will respond to 1 pilocarpine anthers miosis will occur adies tunic pupil: it manifests as the denervation super sensitivity. Normal people respond to 1 pilocarpine but does not contract with highly diluted solution may also result in constriction Uncal herniation : IT results in pressure on 3rd cranial nerve and presents as dilated pupil but it will respond to pilocarpine as the receptors are intact 