<prompt> Most common CVS lesion in Down syndrome is:VSDEndocardial cushion defectTOFCOA  <response>: b. Endocardial cushion defectRef: Nelsons 20e p 610-615, Ghai 8e p 637-639Most common cardiac defect in Down syndrome is Endocardial cushion defect or Atrioventricular septal defect 