<prompt> A 45 dayold infant developed icterus and two days later symptoms and signs of acute liver failure appeared. Child was found to be positive for Hbs Ag. The mother was also s Ag carrier. The mothers hepatitis B serological profile is likely to beHBs Ag positive onlyHBs Ag and Hbe Ag positivityHBsAg and anti - HBe antibody positivityMother infected with mutant HBV  <response>: Perinatal transmission of H VMost important risk factor that determines perinatal transmission is HBe Ag. HBs Ag carrier mothers who are HBe Ag positive almost invariably 90 transmit hepatitis B infection to their offspring, where as carrier mothers with anti HBe rarely 10 to 15 infect their offspring.Most common time of perinatal transmission is at the time of delivery.Most of the infected neonates are asymptomatic carrier with increased chances of chronic hepatitis and hepatocellular carcinoma. 