<prompt> Bromocriptine is agonist of -DopamineSerotonineAcetylcholineEpinephrine  <response>: Ans. is a i.e., Dopamine Bromocriptineo It is synthetic ergot derivativeo It is a potent dopamine agonist.o It has greater action on D2 receptors, while at certain dopamine sites in brain it acts as partial agonis or antagonist of D1 receptor.o It is also a weak a-adrenergic blocker.o The actions of bromocriptine is due to dopamine like effect dopaminergic on D2 and less common D1 receptors.1 Dopamine inhibits the secretion of prolactin - Bromocriptine does the same.2 Dopamine increases the secretion of GH in normal individuals but decreases in acromegalics - Bromocriptine also has same effect.3 Dopamine stimulates CTZ and causes nausea, vomiting - same is true with bromocriptine - Nausea vomiting are the commonest adverse effects.4 Dopamine decreases GI motility - Bromocriptine has same effect.5 Levodopa is an immediate precursor of dopamine - so, bromocriptine also has levodopa like action in CNS.Other D2 agonists1 Cabergoline- More potent and longer acting D2 agonist than bromocriptine.- It is preferred for acromegaly and hyperprolactinoma.2 Quinagolide- Other D2 agonist effective for hyperprolactinoma.3 Pergolide- D2 agonist. 