<prompt> All of the following statements about digitalis are true except :Excretion is mainly renalOral absorption is goodActively metabolized in liverLipid soluble  <response>: Answer is C Actively metabolized in Liver Digoxin is excreted unchanged by the Kidney, mainly by Glomerular filtration. t is not metabolized by liver. Dose of digoxin need not to be changed in Liver failure. Do not confuse digoxin with digitoxin : The most lipid soluble cardiac glycoside is Digitoxin e The most rapidly absorbed oral glycoside is Digitoxin e Digitoxin is primarily metabolized by the liver Q Dose of digitoxin needs to be reduced in liver failure. e 