<prompt> Which of the following hepatitis viruses have significant perinatal transmission :Hepatitis E virusHepatitis C virusHepatitis B virusHepatitis A virus  <response>: Answer is C Hepatitis B Perinatal transmission is most significant with hepatitis B Perinatal transmission of various Hepatitis viruses as described in Harrisons Text: Hepatitis virus HAV HBV HCV HDV HEV Perinatal transmission - - . - Perinatal transmission with HCV is seen primarily with HIV co-infection and high level viremia 