<prompt> Which type diabetes is HLA associated:Type I diabetesType II diabetesMalnutrition related type diseasePregnancy related type diabetes  <response>: Answer is A Type I Diabetes: 95 qt. Type I IDD,iI patients express either HLA DR3 or HLA DR4 or the heterozygous ILLA DR3DR-1 couriviration. Vo HI I association is seen with Type II Diabetes Mellitus or NIDDM.- Harrison Diabetes Mellitus: Review Robbins Harrison Parameters Type I 1DDM Type H NIDDM Patho- physiological difference Results from complete or absolute lack of insulin caused by a reduction in 13 cell mass.Q Autoimmunitv Q is the major culprit - Autoantibodies are present 2 in blood against Results from insufficient insulin secretion relative to glucose load or insulin resistance i.e. inability of peripheral tissues to respond to insulin. Genetic Actor are the major culprit islet cells - No autoantibodies Q - HLA DR3DR4 are Q expressed in 95 of pt. - No HLA association Q - Genetic factors are of low significance Family Not significant Significant History present in less than 15 of patients present in upto 90 of patients Age 40 years Q 40 years Q Habitus Non obese Q ObeseQ Presentation Patient present with sudden onset of osmotic Patient present with a more gradualinsidious onsetQ symptoms in the form of polydipsia, Polyuria or of osmotic symptoms may not he present symptoms of ketoacidosis Many of them may be asymptomatic Q and are recognized when they develop one of the macrovascular or microvascular symptoms of diabetes like delayed healing of wounds with atherosclerosis or gangrene or peripheral neuropathy etc. Complication Ketoacidosis prone Q Ketoacidosis not prone Q Non ketotic hyperglycemic coma Laboratory parameters Blood insulin is decreased Blood glucagon High suppressible Ketonuria: often present Insulin levels are normal or may be increased explained by insulin resistance Blood glucagon High resistant Not present Pathology Early insulitis Marked atrophy and fibrous No insulitis Focal atrophy and amyloid Beta cell depletion Mild p cell depletion Insulin Low High C-peptide 