<prompt> Which of the following is drug of choice for CMV retinitis?AcyclovirTenofovirGanciclovirAbacavir  <response>: Doc for CMV retinitis - Ganciclovir Other drugs used - Foscarnet, cidofovir Herpes simplex virus HSV, Varicella zoster virus VZV - Acyclovir Anti HIV drugs - Tenofovir, Abacavir Ganciclovir: Activated intracellularly by virus specific thymidine kinase Due to poor oral absorption, bioavailability of ganciclovir is low 10 Its prodrug valganciclovir ,which is better absorbed orally, has replaced it for oral therapy Systemic SE: Bone marrow depression Rash ,fever,vomiting Neuro psychiatric disturbances 