<prompt> Leading cause of ACTH independent Cushing syndrome is?Adrenocoical carcinomaMacro-nodular adrenal hyperplasiaMicro-nodular adrenal hyperplasiaAdrenocoical adenoma  <response>: ACTH independent Cushing Syndrome : constitutes 10 of total cases of Cushing syndrome. The causes of ACTH independent Cushing syndrome: Adrenocoical adenoma MC Adrenocoical carcinoma Macro-nodular adrenal hyperplasia 1 The most common cause MCC of ACTH dependant Cushing syndrome is Pituitary coicotroph adenoma. 