<prompt> Gilbe syndrome, true all exceptCauses cirrhosisAutosomal dominantNormal liver function testNormal histology  <response>: Gilbes Syndrome This is the commonest of the familial, genetically-determined diseases of the liver affecting 2-5 of the population. Gilbes syndrome is characterised by mild, benign, unconjugated hyperbilirubinaemia serum bilirubin 1-5 mgdl which is not due to haemolysis. The condition is inherited as an autosomal dominant character. The defect in bilirubin metabolism is complex and appears to be reduced activity of UDP-glucuronosyl transferase with decreased conjugation, or an impaired hepatic uptake of bilirubin. The jaundice is usually mild and intermittent. MORPHOLOGIC FEATURES: There are no morphologic abnormalities in the liver except some increased lipofuscin pigment in centrilobular hepatocytes. The prognosis of patients with Gilbes syndrome is excellent, though chronic jaundice persists throughout life. TEXTBOOK OF PATHOLOGY 6TH EDITION HARSH MOHAN PAGE NO:600 