<prompt> Splenic macrophages in Gauchers disease differ from those in ceroid histiocytosis by staining positive for forLipidsPhospholipidsAcid fast stainIron  <response>: Gaucher disease results from mutation in the gene that encodes glucocerebrosidase. This deficit leads to an accumulation of glucocerebroside, an intermediate in glycolipid metabolism, in the mononuclear phagocytic cells and their transformation into so-called Gaucher cells. Gaucher cells contain abundant lipid-laden granular cytoplasm. Robbins Basic Pathology, 9 th edition. page : 231 