<prompt> The most frequent cause of recurrent genital ulceration in a sexually active male is:Herpes genitalisAphthous ulcerSyphilisChancroid  <response>: Sexually transmitted herpes simplex virus type IIHSV infections cause most genital ulcer disease. Disease Herpes 62 Chanchroid 12 to 20 Syphilis 13 LGV and Granuloma Inguinale 5 Herpes ulcers are painful, vesicular, multiple and are associated with firm tender lymphadenopathy. 