<prompt> The endothelins are secreted mainly by endothelial cells. All of the following are true, EXCEPT:Enhances renal pressure natriuresisVasoconstrictionDecreased GFRAct on the hea to cause hyperophy  <response>: Endothelin-1 ET-1, the most powerful vasoconstrictor produced in humans. ET-1 decreases GFR and renal plasma flow through stimulation of vascular smooth muscle and mesangial cell contraction. ET-1 can also act on the hea to cause hyperophy, on the adrenal gland to release aldosterone, and on the kidney to promote sodium and water retention. Ref: Hall J.E., Granger J.P., Jones D.W., Hall M.E. 2011. Chapter 69. Pathophysiology of Hypeension. In V. Fuster, R.A. Walsh, R.A. Harrington Eds, Hursts The Hea, 13e. 