<prompt> Use of tamoxifen for breast cancer can cause all of the following adverse effects, except:ThromboembolismEndometrial carcinomaCarcinoma in contralateral breastCataract  <response>: Ans. c. Carcinoma in contralateral breast Tamoxifen is associated with reduced risk of cancer in the contralateral breast.Tamoxifen is approved for primary prophylaxis of breast cancer in high risk women. If reduces the recurrence rate of breast cancer in ipsilateral as well contralateral breastTamoxifen is associated with reduced risk of cancer in the contralateral breast.Tamoxifen is used to treat hormone- responsive breast cancer.Tamoxifen is a competitive inhibitor of estradiol, binding to the estrogen receptor. It has become a standard agent as a result of its anti-cancer activity and good tolerability profile. Tamoxifen is prescribed for the prevention of breast cancer in high-risk patients, for the adjuvant therapy of early stage breast cancer, and for the therapy of advanced breast cancer. It also prevents development of breast cancer in woman at high risk based on a strong family history, prior non-malignant breast pathology, or inheritance of the BRCA1 or BRCA2 genes.- Goodman and Gilman 12e p1756-1757TamoxifenTamoxifen is a standard hormonal treatment of breast cancer in both premenopausal and postmenopausal womenQTamoxifen is effective in Estrogen Receptor ER positive breast carcinoma but some ER negative tumors also respond to tamoxifenQ.Tamoxifen is approved for primary prophylaxis of breast cancer in high risk womenQIf reduces the recurrence rate of breast cancer in ipsilateral as well contralateral breastQTamoxifen is associated with reduced risk of cancer in the contralateral breastQ.Dose: 10 mg BD X 5-yearsQWhile tamoxifen blocks estrogen receptors on the breast, it stimulates these receptors in the uterus because tamoxifen is a partial against of ER, may lead to endometrial hyperplasia and endometrial cancerQPotent antagonist in breast carcinoma cells, blood vessels and at some peripheral sitesQQPartial agonist in the uterus, bone, liver and pituitaryAdverse Effects of Tamoxifen Hot flushes, nausea and vomiting MC Menstrual irregularities, vaginal bleeding, discharge, pruritus vulvae and dermatitis Endometrial cancer Thromboembolism Cataract Retinal deposits and decreased visual acuity 