<prompt> Mechanism of action of Clomiphene citrate used for infeility:-Block estrogen receptors in the hypothalamusNegative feedback on HPO axisDirect action on ovarian primordial folliclesIncrease in tubal motility  <response>: The ability of Clomiphene citrate CC to initiate an ovulatory sequence is primarily due to its ability to be recognized by and interact with the estrogen receptors in hypothalamus. In its capacity as an Estrogen antagonist,CC displaces endogenous estrogen from hypothalamic estrogen receptor sites and hence inhibiting the negative feedback of the endogenous estrogen on the hypothalamus Reproductive Medicine Surgery, Wallach and Zacur, Mosby 95. In simple terms, there is non recognition of the bodys estrogens by the hypothalamus due to the blockade of estrogens receptors by CC and hence the hypothalamus directs the pituitary to make more of FSH which in turn drives the ovary to make a follicle to make estrogens.The development of follicle is the preceeding event before ovulation. 