<prompt> Tropical Splenomegaly is characterized by all the following, except ___Persistent high grade feverModerate to massive splenomegalyResidence in areas endemic for MalariaClinical response to antimalarials  <response>: Tropical splenomegaly Big spleen diseasefound in adults in ceain hyper endemic malarial areas has been shown to be related to an abnormal immune response to plasmodial antigen features hepatomegaly anemia leucopenia massive splenomegaly increased serum IgM concentrations. continuous malaria chemoprophylaxis over many months cause a gradual reduction in the spleen size and clinical improvement Ref : PARASITOLOGY, K.D.CHATTERJEE,13 TH edition, Pg no:117 