<prompt> A one year old child having leucocoria was detected to be having a unilateral, large retinoblastoma filling half the globe. Current therapy would involve-EnucleationChemotherapy followed by local dyesDirect laser ablation using photodynamic cryotherapyScleral radiotherapy followed by chemotherapy  <response>: Tumor involving less than half of the globe- Multimodal therapy chemoreduction followed by local destruction. Tumor involving half or more of the globe - Enucleation. Ref: Wills Eye hospital at las of Clinical ophthalmology p.269. 