<prompt> All of the following statements about immunosuppressants are true EXCEPT :Sirolimus acts by inhibiting the action of IL2Tacrolimus inhibits calcineurin pathwayMycophenolate acts by inhibiting GMP dehydrogenaseCyclosporine is an integeral component of transplant rejection regimen  <response>: Mycophenolate mofetil acts by blocking IMP dehydrogenase.Cyclosporine and tacrolimus are calcineurin inhibitors that act by decreasing the transcription of IL-2 gene. Cyclosporine is commonly used to prevent rejection in transplant recipients.Sirolimus acts by inhibiting mTOR a tyrosine kinase that is the target of IL-2. 