<prompt> Carbonic anhydrase inhibitors should not be given inSulfonamide hypersensitivityGlaucomaHigh altitude sicknessMetabolic acidosis  <response>: Carbonic anhydrase inhibitorsCAIsare more likely to produce acidosis in patients of COPD,CRF and DM.They are contraindicated in COPD as they may precipitate respiratory acidosis. They are sulfonamides in structure,so should not be given in hypeensitive persons. 