<prompt> Metabolism of a drug primarily results in:Activation of the inactive drugConversion of prodrug to active metaboliteConversion of lipid soluble drugs to water soluble metabolitesConversion of water soluble drug to lipid soluble metabolites  <response>: Major aim of metabolism Biotransformation is to conve lipid-soluble non-polar drugs to water soluble polar drugs. In the absence of metabolism, body will not be able to get rid of lipophilic substances, and they will become very long acting. Biotransformation of drugs may lead to any of the following 1. Inactivation of an active drug 2. Conversion of active drug to its active metabolite 3. Activation of inactive drug prodrug 