<prompt> Which of the following cytokine is associated with the development of cell-mediated immunity?IL-3IL-4IL-5IL-I2  <response>: Gamma interferon from T helper 1 CD4 lymphocytes and IL-12 from macrophages are major stimulators of the development of a cell-mediated immune response to intracellular organisms such as tuberculosis, leishmaniasis, histoplasmosis, and many other organisms. Good to know: IL-3 is a cell growth factor produced by thymic epithelial cells and T cells to regulate different T cell differentiation processes. IL-4 is produced by T helper 2 CD4 lymphocytes and is involved in class switching to IgE. It also down regulates T helper 1 CD4 lymphocytes. IL-5 is produced by T helper 2 CD4 lymphocytes and is involved in IgA production, eosinophil differentiation, and B cell differentiation. Ref: Levinson W. 2012. Chapter 58. Cellular Basis of the Immune Response. In W. Levinson Ed, Review of Medical Microbiology Immunology, 12e. 