<prompt> A patient with cirrhosis of liver has the following coagulation parameters, Platelet count 2,00,000, Prothrombin time 25s12s, Activated paial thromboplastin time 60s35s, thrombin time 15s 15s. In this patient-D-dimer will be normalFibrinogen will beATIII will be highProtein C will be elevated  <response>: Ans. is a i.e., D-dimer will be normal Coagulation defects in severe liver disease Coagulation factors platelets Platelet --- Variably decreased Fibrinogen factor XI and factory XIII --- Variably decreased Prothrombin, factor, VII, IX and X --- Decreased Factor V --- Usually decreased Factor VIIIC Von willebrands factor -- Usually increased Thrombin time Prothrombin time --- Usually increased Paial thromboplastin time -- Increased Test for fibrinolvsis and fibrin degradation products Plasminogen a --Antiplamin --- Variably decreased Fibrin degradation products -- Usually increased Plas min -- Variably increased D -- Dimer -- Usually normal Miscellaneous Antithrombin -- Variably decreased Protein C and Protein S Decreased 