<prompt> Which of the following play the most impoant role in pathogenesis of Rheumatoid AhritisCD4 T cellsCD8 T cellsB cellsGranulocytes  <response>: CD4 T cells plays the most impoant role in orchestrating the chronic inflammatory response in Rheumatoid Ahritis. CD4 T cells are the major component of the inflammatory infiltrate in the rheumatoid synovium. Chronic inflammatory response in Rheumatoid Ahritis T cells CD4 are the major component of the inflammatory infiltrate in the rheumatoid synovium. The T cells compromise 30-50 of the infiltrate, with the other cells accounting for the remainder. Evidence suggests that CD4 T cells play an impoant role in orchestrating the chronic inflammatory response in RA. However, other cell types, such as CD8 T cells, natural killer NK cells, and B cells are present in synol tissue and may also influence pathogenic responses The inflammatory infiltrate is made up of no less than six cell types: T cells Most abundant B cells Plasma cells Dendritic cells Mast cells and Granulocytes to a lesser extent Ref: Harrison;s 19th edition Pgno: 2140 