<prompt> Non-sympathomimetic Bronchodilator preferred in COPD:Ipratropium bromideSalmeterolTerbutalineSalbutamol  <response>: Ans. a Ipratropium bromideRef. Katzung pharmacology 10th ed. Ch 10 Ipratropium bromide is an anti-cholinergic agent Muscarinic antagonists which competitively inhibit the effect of acetylcholine at muscarinic receptors. Ipratropium appears to be at least as effective in patients with COPD that includes a partially reversible component. A longer-acting, selective anti-muscarinic agent, tiotropium, is approved as a treatment for COPD. Salbutamol and terbutaline are b2 agonist, used in acute cases of asthma. Salmetrol is slow acting b2 agonist, used for prophylaxis of asthma. 