<prompt> Cyclosporin-A acts on:CD4 cells and lymphocytesCD8 cells and lymphocytesCD16 cells and lymphocytesB-lymphocytes  <response>: Cyclosporine binds to intracellular cyclophilin, and this complex interacts with calcineurin. Calcineurin is crucial for normal lymphokine gene activation, and its inhibition by cyclosporine consequently interferes with the production of interleukins-2, -3, and -4 IL-2, IL-3, and IL-4, tumor necrosis factor-alpha TNF-, and other impoant mediators of inflammation. In turn, specific and potent inhibition of T-cell activation especially CD4 cells is achieved. Adverse effects: The most frequently encountered problem with cyclosporine is nephrotoxicity, and in many patients cyclosporine causes a rise in serum creatinine level and a reduction of glomerular filtration rate GFR. Ref: Scales D.C., Granton J.T. 2005. Chapter 90. The Transplant Patient. In J.B. Hall, G.A. Schmidt, L.D. Wood Eds, Principles of Critical Care, 3e. 