<prompt> Which diuretic acts without requiring access to renal tubular lumenThiazideCarbonic anhydrase inhibitorsAldosterone antagonistsLoop diuretics  <response>: Mechanism of action of diuretics: Aldosterone antagonists: Aldosterone acts by combining with an intracellular mineralocoicoid receptor It induces the formation of aldosterone-induced proteins AIP . These AIPs promote Na reabsorption and K secretion Spironolactone is an aldosterone antagonist It acts from the interstitial side of the tubular cell It combines with Mineralocoicoid Receptor and inhibits the formation of AIPs 