<prompt> Red degeneration in uterine fibroid is most common in:Second trimesterThird trimesterPuerperiumFirst trimester  <response>: Ans. is a, i.e. Second trimesterRef: Jeffcoate 7thed p502Read for yourself what - Ref: Dutta Obs. 6thed p309 has to sayRed degeneration; It predominantly occurs in a large fibroid during the second half of pregnancy or puerperium.From the above statement answer could be second trimester, third trimester or puerperium.Red degeneration; manifests typically about mid pregnancy when the leiomyoma suddenly become acutely painful, enlarged and tender. - Ref: Jeffcoate 7thedp502This clears the doubts and confirms our answer, i.e. red degeneration is most common during second trimester mid pregnancy.You should also keep in mind the following important points regarding-Fibroids and pregnancy. Most fibroids do not increase in size during pregnancy. Only 5 females with fibroid have degeneration during pregnancy. 