<prompt> Drugs of the choice for central diabetes insipidus isDesmopressinLeuprolideThiazide diureticsInsulin  <response>: Desmopressin is treatment of choice for central diabetes insipidus. It acts selectively at V2 receptors to increase urine concentration and decrease urine flow in a dosedependent Manner. It is also more resistant to degradation than AVP and has a three- to fourfold longer duration of action. Desmopressin can be given by IV or SC injection,nasal inhalation,or oral tablet. 