<prompt> In hereditary spherocytosis, an inherited abnormality is seen in which of the following red blood cell component?a-globin chainb-globin chainPhosphatidyl inositol glycan ASpectrin  <response>: Hereditary spherocytosis HS is caused by diverse mutations that lead to an insufficiency of membrane skeletal components. The pathogenic mutations most commonly affect ankyrin, band 3, spectrin, or band 4.2. 