<prompt> Which of the following syndromes is best associated with congenital hea diseaseLesch-Nyhan syndromeRasumussen syndromeHolt oram syndromeLEOPARD syndrome  <response>: Holt oram charge association syndrome is a autosomal dominant disease characterized by Cardiac lesion ostium secundum ASD,VSD,TOF, pulmonary stenosis, coloboma, choanal atresia,genital hypoplasia,ear abnormalities,growth retardation due to TBX5 mutation Lesch nyhan syndrome juvenile gout is associated with self mutilation of hand feet,intelluctal disability,early death Rasmussen syndrome is chronic focal encephalitis character used by seizure,hemiparesis,aphasia,dementia Leopard noon an syndrome ,there will be Lentigines,Electrocardiographic conduction anomaly,Ocular hypeelorism, Pulmonary stenosis,Abnormal genitalia,Retarded growth Deafness Ref : Ghai essential of pediatrics, eighth edition, p.no:401 