<prompt> Adrenal suppression is a side effect of:-Thiopentone sodiumKetaminePropofolEtomidate  <response>: Etomidate inhibits 11-beta hydroxylase enzyme in adrenal coex. ETOMIDATE Etomidate is a carboxylated imidazole - containing anesthetic compound structurally unrelated to any other IV anesthetics. Aqueous solution of etomidate is unstable at physiologic pH and a formulated in a 0.2 solution with 35 prophylene glycol. IV injection causes pain on injection, veno irritation and hemolysis. CNS - Decreases CMRO2, CBF and ICP Cerebroprotective Decreases EEG activity CVS - Minimal cardiorespiratory depression even in the presence of cardiovascular and pulmonary disease. No histamine release. R.S - Respiratory depression Blunts hypoxic hypercapnic drive Bronchodilator Hepatic Renal - Side Effects 1. Adrenal coex suppression Etomidate inhibits the activity of 11- B hydroxyl- lase, an enzyme necessary for the synthesis of coisol, aldosterone, 17 - hydroxyl - progesterone and coicosterone. 2. Pain on injection 3. High incidence of postoperative nausea and vomiting 4. Myoclonic activity 5. Inhibit platelet function Uses:- Induction agent of choice for poor- risk 