<prompt> A patient having prinzmetal angina is started with ISMN. Patient got symptomatic relief from angina. What is the MOA?Endothelium independent coronary vasodilatationReduced cardiac contractilityIncreased left ventricular end diastolic volumeDecreased diastolic perfusion pressure  <response>: ANS. A Important points on nitrates1. All nitrates have high FPM metabolism except ISMN Isosorbide mononitrate2. Skin rashes are maximum with Pentaerythritol tetranitrate3. Nitrates used in acute attack: NTG and ISDN Isosorbide dinitrite 