<prompt> Drug of choice for Zollinger-Ellison syndrome is:-CimetidineOmeprazoleMisoprostolAluminium hydroxide  <response>: Proton pump inhibitors are the drugs of choice for peptic ulcer disease PUD due to any etiology even NSAID induced. These are also the agents of choice for gastroesophageal reflux disease GERD and Zollinger Ellison Syndrome ZES. Zollinger Ellison syndrome: It is a Pancreatic or duodenal gastrinoma which leads to secretion of large amounts of gastric acid causing severe ulcers and hyperchlorhydria. PPI are better than H2 blockers in this condition. 