<prompt> Regarding adverse reaction of anti convulsants, all are true, EXCEPT :Phenobarbitone - CVS defectCarbamazepine - breech presentationPhenytoin-gum hyperplasiaSodium valproate neural tube defect  <response>: Ans. is b Carbamazepine -breech presentation, Teratogenic effects of Antiepileptic drugsDrugsTrimesterEffect1. Barbiturates PhenobarbitoneAllCongenital heart diseasesCleft lip, palateNeonatal dependenceRespiratory depression2. ValproateAll Neural lube defects3. CarbamazepineAll Neural tube defects4. PhenytoinAll Fetal hydantoin syndromeAdverse effects of phenytoinAt therapeutic levelAt high plasma level1. Hypertrophy Gum M.C.1. Cerebellar ataxia 2. Hirsutism2. Epigastric pain3. Hypersensitivity reaction Rash, DLE3. Fall in B.P. and cardiac arrhythmia4. Hyperglycemia4. Drowsiness5. Hydantoin syndrome Fetal 6. Osteomalacia 7. Megaloblastic anaemia 