<prompt> The term end-stage renal disease ESRD is considered appropriate when GFR falls to50 of normal25 of normal1025 of normal510 of normal  <response>: Most children with GFR 30 of normal are asymptomatic. Reduction of GFR below 2530 mLmin1.73 m2 is associated with symptoms. End-stage renal disease ESRDGFR of 510 mLmin 1.73 m2, characterized by decline of renal function to adegree when life cannot be sustained without chronic dialysis or transplantation. 