<prompt> Natalizumab is used in treatment of -Muliple sclerosisBreast carcinomaPsoriasisB cell lymphoma  <response>: Ans. is a i.e., Multiple sclerosis Treatment of multiple sclerosiso Multiple sclerosis is an autommune disease characterized by chronic inflammatory demylination that affects the CNS.o The most common course of the disease is the relapsing-remitting subtype, which is characterized by unpredictable acute attacks relapses followed by periods of relative remission with no new signs of disease activity. The other type less common is progressive subtype, which is characterized by a steady functional decline from disease onset.o Therapy for MS can be divided into several categories:-Treatment of acute attackCorticosteroids Methyiprednisolone, prednisolone are usedTreatment with disease-modifing agents that reduce the biological activity of MSy Disease modifying agents for multiple sclerosis are i IFN-fi la; ii IFN-fi lb, iii Glatiramer; iv Natalizumab: v Finoglimod: vi Mitoxantrone; vii Cladaribine.Other treatment optionsOther off-label treatment options are i methotrexate; ii cyclophosphamide; iii IV immunoglobulins; iv azathioprine.Symptomatic TreatmentIt includes healthy diet, regualr exercise, and:Treatment of rigidity baclofen, diazepam, tizanidine, dantrolineTreatment of weakness Potassium channel blockers like 4-aminopyTidineTreatment of pain by anticonvulsants carbamezapine, phenytoin, gabapentin, pregabalin, or antidiepressants mexiletin.Treatment of UTI, bladder dysfunction, constipation, depression, fatigue and cognitive problems. 