<prompt> Most common cause of Cushings syndrome is -Pitutary adenomaAdrenal adenomaAdrenal carcinomaMcCune Albright syndrome  <response>: Ans. is a i.e., Pituitary adenoma o ACTH-secreting pituitary adenomas account for approximately 70 of cases of endogenous hypercortisolism Cushings syndrome.Endogenous Causes of Cushing SyndromeCauseRelative Frequency Ratio of Females to MalesACTH-DEPENDENT Cushing disease pituitary adenoma; rarely CRH dependent pituitary hyperplasia Ectopic corticotropin syndrome ACTH-secreting pulmonary small cell carcinoma, bronchial carcinoid.703?5:1?0101:1ACTH-IN DEPENDENT Adrenal adenoma Adrenal carcinoma Macronodular hyperplasia ectopic expression of hormone receptors, including GIPR, LHR, vasopressin and serotonin receptors. Primary pigmented nodular adrenal disease PRKARIA and PDE11 mutations. McCune-Albright syndrome GNAS mutations10524:11:11:121:121:1 