<prompt> False regarding HMP shuntNADPH is producedRibulose 5 phosphate is producedATP is producedOccurs in cytosol  <response>: Ans. is c i.e., ATP is produced HMP shunt does not produce ATP. HMP shunt HMP shunt is a multicyclic process in which 3 molecules of glucose-6-phosphate give rise to 3 molecules of CO2 and 3 molecules of 5-carbon sugars ribulose-5-phosphate. The latter are rearranged to generate 2 molecules of glucose-6-phosphate through fructose-6-phosphate and l molecule glyceraldehyde-3-phosphate. HMP shunt does not generate ATP. 3 Glucose-6-phosphate 6 NADP - 2 glucose-6-phosphate 1 glyceraldehyde-3-phosphate 6 NADPH 3CO2 The reaction of HMP shunt are divided into two phases : - i Phase I Oxidative irreversible phase : - During this phase, 3 molecules of glucose-6-phosphate are oxidized with generation of 6 molecules of NADPH, and three molecules of pentose phosphate ribulose?5-phosphate, with liberation of three molecules of CO2. Metabolites produced during this phase are 6- phosphoglucanolactone, 6-phosphogluconate and ribulose-5-phosphate. ii Phase II Non-oxidative reversible phase : - During this phase, pentose phosphate is conveed to intermediates of glycolysis, i.e., glucose-6-phosphate and glyceraldehyde-3-phosphate. Intermediary metabolites of this phase are xylulose-5-phosphate, ribose-5-phosphate, sedoheptulose-7-phosphate, erythrose-4- phosphate and fructose-6-phosphate. HMP shunt occurs in the cytosol. It is highly active in liver, adipose tissue, adrenal coex, lens, cornea, lactating but not the nonlactating mammary gland, Gonads testis, ovary and erythrocytes. Activity of this pathway is minimal in muscle and brain, where almost all of the glucose is degraded by glycolysis. 