<prompt> Mutations in type I collagen fibres results is:Marfans syndromeOsteosclerosisOsteopetrosisOsteogenesis imperfecta  <response>: Osteogenesis imperfecta 268-M 153-Apleys 8th Osteogenesis imperfecta Brittle bones is one of the commonest of the genetic disorders of bone. Abnormal synthesis and structural defects of type I collagen results in abnormalities of bones teeth, ligaments, sclerae and skin.Clinical features are1. Osteopenia2. Liability to fracture3. Laxity of ligaments4. Blue colouration of the sclerae5. Dentinogenesis imperfecta Grumbling teeth 