<prompt> Most common cause of splenic rupture is -MalariaITPThalassemiaCirrhosis  <response>: Most common cause of splenic rupture is Trauma.In the absence of trauma Spontaneous rupture of spleen occurs due to some minor physical insult to a spleen that has been rendered fragile by an underlying condition. The most common predisposing conditions are IMN, malaria, typhoid fever and lymphoid neoplasms. 