<prompt> The conjugation of bilirubin to glucuronic acid in the liver -Converts a hydrophilic compound to a hydrophobic oneConverts a hydrophobic compound to a hydrophilic oneEnables the bilirubin molecule to cross the cell membraneIs increased during neonatal jaundice  <response>: Unconjugated bilirubin hydrophobic is converted to conjugated bilirubin hydrophilic by the process of conjugation with UDP-glucuronic acid in the liver.As conjugated bilirubin is hydrophilic not lipophilic it cannot cross the plasma membrane easily lipophilic or lipid soluble substances cross plasma membrane easily. Thus, unconjugated bilirubin lipophilic can cross plasma membrane easily but not conjugated bilirubin hydrophilic.In neonatal jaundice, conjugation process is immature. 