<prompt> Presence of 10 plasma cells with no lytic lesion and M protein in serum is seen in?Smoldering myelomaMultiple myelomaMonoclonal Gammopathy of unknown significanceNon secretory Myeloma  <response>: Ans. a Smoldering myelomaRef: Harrison 19th ed.715Diagnostic Criteria for Multiple MyelomaMONOCLONAL Gammopathy of Undetermined Significance is defined by the presence of three criteria: Serum monoclonal M protein M-protein concentration 3gdL Bone marrow plasma cell concentration 10 No evidence of end organ damageSmoldering MM is present when the: Serum M protein concentration is 3 gdL Bone marrow plasma cell concentration is 10 No evidence of end-organ damage.Symptomatic myeloma is present when the M-protein 30 gL Bone marrow clonal cells 10 Must have evidence of ROTI end-organ damage that can be attributed to the plasma cell proliferative process; manifested by CRAB calcium, renal failure, anemia, and bone lesions. 