<prompt> Anti ds DNA antibody is specific for: PGI May 2010SLESystemic sclerosisCREST syndromeSjogrens syndrome  <response>: Ans. A SLE Anti-dsDNA 70DNA double- strandedHigh titers are SLE-specific and in some patients correlate with disease activity, nephritis, vasculitisHigh-titer IgG antibodies to double-stranded DNA and antibodies to the Sm antigen are both specific for SLE and, therefore, favor the diagnosis in the presence of compa tible clinical manifestationsTable Harrison; Diagnostic Criteria for Systemic Lupus ErythematosusMalar rashFixed erythema, flat or raised, over the malar eminencesDiscoid rashErythematous circular raised patches with adherent keratotic scaling and follicular plugging; atrophic scarring may occurPhotosensitivityExposure to ultraviolet light causes rashOral ulcersIncludes oral and nasopharyngeal ulcers, observed by physicianArthritisNonerosive arthritis of two or more peripheral foints, with tenderness, swelling, or effusionSerositisPleuritis or pericarditis documented by ECG or rub or evidence of effusionRenal disorderProteinuria 0.5gdQ or 3 or cellular castsNeurologic disorderHematologicdisorderSeizuresQ or psychosis without other causesHemolytic anemia or leukopenia 4000 mL Q or lymphopenia 1500pL or thrombocytopenia 100,000mL Q in the absence of offending drugsImmunologicdisorderAntinuclearantibodiesAnti-dsDNAQ anti-Sm, andor antiphospholipidAn abnormal titer of ANAQ by immunofluorescence or an equivalent assay at any point in time in the absence of drugs known to induce ANAsTable Harrison: Antinuclear Antibody ANA Patterns and Clinical AssociationsANA PatternAntigen IdetifiedClinical CorrelateDiffuseDeoxyribonucle - oproteinNonspecific HistonesQDrug-induced lupus,Peripheral rimds-DNA50 of SLE specificSpeckledUl-RNP90 ofMCTD Sm30 of SLE specific Ro SS-A QSjogrens 60, SCLE, neonatal lupus, ANA - lupus La SS-BQ50 ofSjogrens, 15 lupus Scl-7040 of diffuse sclerodermaQ PM-1Polymyositis PM, dermatomyositis Jo-1PM w pneumonitis arthritisNucleolarRNA polymerase 1, others40 ofPSSCentromereKinetochone75 CRESTflimited scleroderma 