<prompt> In Peutz-Jeghers syndrome, polyps are mainly seen in:RectumColonEsophagusJejunum  <response>: In Peutz-Jeghers syndrome, polyps are mainly seen in Jejunum Peutz-Jeghers syndrome Autosomal dominant disorder Most common in small intestine- Jejunum Germ line loss of function mutations in LKB1STK11 gene are present May occur in stomach, colon with much lower frequency in bladder and lungs Multiple gastrointestinal hamaomatous polyps Mucocutaneous hyperpigmentation Gross- Polyps are large pedunculated with lobulated contour Histologic findings : characterized by proliferation of the muscularis mucosae to form branching configurations covered by hyperophic, but otherwise normal mucosa 