<prompt> The most impoant action of beta-blockers in glaucoma is :Membrane stabilizing effectRefinal neuron protecting effectDecrease in the production of aqueous humorPupillary constriction  <response>: Ref: KD Tripathi pharmacology 7th edition page.no: 144 Topical b blockers are one of the first-line drug for glaucoma In contrast to miotics, the b blockers do not affect pupil size, the tone of ciliary muscle or outflow facility, but lower i.o.t. by reducing aqueous formation. This probably results from down-regulation of adenylyl cyclase due to b 2 receptor blockade in the ciliary epithelium and a secondary effect due to a reduction in ocular blood flow. 