<prompt> A 60-year-old man presents with complains of change in handwriting, tremors, rigidity and slowness of activities. The possible diagnosis isSupranuclear gaze palsyAlzhemers diseaseParkinsons diseasePosterior circulation stroke  <response>: Ans. c Parkinsons disease. Ref Harrison, Internal Medicine, 16th ed., 2406PARKINSONS DISEASE PDClinical Features: Tremors pill rolling 85. Rigidity cog wheelplastic BradykinesiaClassical clinical triad Others: Mask facies, Stooped posture, Micrographia, Hypophonia, Sialorrhea, Freezingshort shuttling gait, Anosmia, Akathesia, Sleep disorders, Autonomic dysfunction, Neuropychiatric symptoms Postural instability with repeated in first year strongly suggests the diagnosis other than PD.Rx: Dopamine agonists pergolide, bromocriptine, ropinirole, pramipexole Carbidopa, levodopa COMT inhibitors tolcapone, entacapone MAO inhibitors selegiline Quetiapine Clozapine Anticholinergics: Trihexiphenidyl benzhexol, Procyclidine, Benztropine, Biperiden drug of choice in drug induced parkinsonism. Amantadine Anti-glutameric riluzole ... Primarily used in Rx of ALS Minocycline Co enzyme Q10. 