<prompt> Retinoblastoma isAutosomal dominantAutosomal recessiveX - linked recessiveX- linked dominant  <response>: Autosomal dominant 280- Khurana 4thRETINOBLASTOMA - Most common intraocular tumour of childhood and malignant melanoma of choroid in adults Identified as band on the long arm of chromosome 1313ql4 Most hereditary cases are multifocal Inheritance is autosomal dominant and the risk of transmitting the gene mutation is 50 Leukocoria ox yellowish - while pupillary reflex also called as amaurotic cats eye appearance is the commonest features In the presence of calcification it gives the typical Cottage- cheese appearance Calcification occurs in 75 is almost pathognomic of Retinoblastoma Enucleation is the treatment of choice when Tumour involves more than half of the retina Optic nerve is involved Glucoma is present and anterior chamber is involved External beam radiation therapy spares vision and the cosmetic use of the globe Palliative therapy chemotherapy, surgical debulking of the orbit or orbital exentration and External beam radiotherapy EBRT is given in following cases where prognosis for life is dismal in spite of aggressive treatment Retinoblastom with orbital extension Retinoblastoma with intracranial extension Retinoblastoma with distant metastasis 