<prompt> Non-immune hemolytic anemia occurs in -SLEP. vivax infectionCLLCML  <response>: Non-Immune hemolytic anemiaIn non-immune hemolytic anemia, hemolysis occurs without formation of antibodies against RBCs.Combs test is negative, therefore it is also known as Coombs negative hemolytic anemia.Causes are : -Drugs RibavirinToxins Snake venum, plant poisons such as aesculin.Mechanical trauma to RBCs prosthetic heart valve, thrombosis in microcirculation.Microangiopathic hemolytic anemia :- Thrombotic thrombocytopenia purpura TTP, Hemolytic uremic syndrome HUS, DIC, HELLP syndrome.Infections : -Babesiosis, Malaria, Clostridium perfringens sepsis.Hereditary spherocytosis, Thalassemia, SCA,Paroxysmal nocturnal hemoglobinuria, Liver disease. 