<prompt> Gastrointestinal stromal malignancy arises from which of the following -Smooth muscleNerve cellsInterstitial cells of CajalVascular Endothelium  <response>: Gastrointestinal stromal tumors GIST originate from the interstitial cells of Cajal, which controls gastrointestinal peristalsis.On rare occasions, gastric GISTs occur as part of tumor - syndrome, such as :-Carneys trads Gastric GIST, Paraganglioma and pulmonary chondroma.Neurofibromatosis Type IHistologically, GISTs can be divided intoSpindle types Exhibit spindle cellsEpithelioid types Exhibit epithelioid cellsMixed types A mixture of both 