<prompt> All are true regarding blood supply increase in muscle during exercise exceptLocal metaboliteSympathetic stimulationCholinergic stimulationInhibition of beta receptor  <response>: Ans. D. Inhibition of beta receptor.CHANGES IN MUSCLE BLOOD FLOW DURING EXERCISEThe blood flow of resting skeletal muscle is low 2-4 ml.100 gmin. The muscle blood flow can increase a maximum of about 25 fold during the most strenuous exercise.Amount of blood flow to skeletal muscles during exercise : 50 to 75 mLmin of blood per 100 g of muscle.Dilation of aerioles in skeletal muscles due to cholinergic sympathetic nerve activity and stimulation of beta-adrenergic receptors by the hormone epinephrine leads to increased blood supply.The local mechanisms maintaining a high blood flow in exercising muscle include a fall in tissue P02, a rise in tissue PCO2, and accumulation of K, and other vasodilator metabolites. The rise in temperature fuher dilates the vessels. 