<prompt> Drug with beta adrenergic blocking, with antioxidant, with calcium channel blocking, with alpha 1 antagonist activity is ?EsmololCarvedilolNebivololLevobunolol  <response>: Ans. is b i.e., Carvedilol Carvedilol Carvedilol is a b1 b2 a1 adrenoceptor blocker with a : b blocking propey of 1 : 9. It has antioxidant and antimitotic propey. It produces peripheral vasodilation due to a-1 blockade as well as calcium channel blockade direct effect. It is used in hypeension and angina. It is used as cardioprotective in CHF. t12 is 2-8 hrs. It is eliminated through liver and kidney. It causes ohostatic hypotension. 