<prompt> The following condition is not associated with an Antiphospholipid syndrome -Venous thrombosisRecurrent foetal lossThrombocytosisNeurological manifestations  <response>: Antiphospholipid syndrome Antiphospholipid syndrome develops in patients expressing antibodies to anionic phospholip. i.e., antiphospholipid antibody or lupus anticoagulant.Remember always, These antibodies are not only against phospholipid as it was believed, of these are antibodies against epitopes of plasma proteins are complexed with phospholipid.Note: Epitope is the portion of an antigen that actually binds with antibody.A variety of protein have been implicated β2-glycoprotein particularly imported, i.e., the antiphospholipid antibody is directed against the phospholipid - β2-glycoprotein complex.Other proteins are prothrombin, protein S, protein C, annexin V.There are two categories of antiphospholipid syndrome.1. Secondary antiphospholipid syndromeWhen antiphospholipid syndrome is associated with SLE and other autoimmune disease like sjogren syndrome, RA, Bechet syndrome, systemic sclerosis etc.2. Primary antiphospholipid syndromeWhen antiphopholipid syndrome develops without associated SLE.Clinical manifestations of antiphospholid syndromeIn antiphospholipid syndrome, there is hypercoagulability which results in recurrent venous and arterial thrombosis. This can affect virually any organ system, including the following -Peripheral venous system DVTCNS Cerebrovascular accident, sinus thrombosis migraine, epilepsy. Haematological Thrombocytopenia, hemolytic anemia.Obstetrics Abortion in 2nd 3rd trimester late fetal loss is common but it may occur any time in pregnancy; recurrent abortion, eclampsia.Pulmonary Pulmonary embolism, pulmonary hypertension. Cardiac Limbman - Sack endocarditis, MI.Dermatological Livedo reticularis, purpura, infarctulceration.Ocular Amaurosis, retinal thrombosis.Adrenal Infarction, hemorrhage.Musculoskeletal Avascular necrosis of bone.Catastrophic antiphospholipid syndrome Multiorgan infarction 