<prompt> Orphan Annie nuclei is seen in?Medullary carcinoma of thyroidAnaplastic carcinoma of thyroidPapillary carcinoma of thyroidFollicular carcinoma of thyroid  <response>: Histologically, papillary carcinomas may exhibit papillary projections, a mixed pattern of papillary and follicular structures, or a pure follicular pattern follicular variant. The diagnosis is established by characteristic nuclear cellular features. Cells are cuboidal with pale, abundant cytoplasm, crowded nuclei that may demonstrate grooving, and intranuclear cytoplasmic inclusions leading to the designation of Orphan Annie nuclei, which allow diagnosis by FNAB. ref - Srbs manual of surgery 5e p481 