<prompt> Chloroquine is given as 600 mg loading dose because:It is rapidly absoedIt is rapidly metabolizedIt has increased tissue bindingIt is rapidly eliminated  <response>: Oral absorption of CQ is excellent. About 50 gets bound in the plasma. It has high affinity for melanin and nuclear chromatin: gets tightly bound to these tissue constituents and is concentrated in liver, spleen, kidney, lungs several hundred-fold, skin, leucocytes and some other tissues. Its selective accumulation in retina is responsible for the ocular toxicity seen with prolonged use. ESSENTIALS OF PHARMAXOLOGY page no.822 