<prompt> BCR - ABL hybrid gene is present inBurkitts lymphomaRetinoblastomaBreast carcinomaCML  <response>: CML 215-HM 315, 697-98-R 464-Basic pathology 8,hBCR-ABL hybrid gene - ABL gene is a non GF receptor proto-oncogene having tyrosine kinase activity. ABL gene from its normal location on chromosome 9 is translocated to chromosome 22. Where it fuses with BCR breakpoint cluster region gene and forms an ABL, BCR hybrid gene which is more potent in signal transduction pathway ABL-BCR hybrid gene is seen in CML and some acute lymphocytic leukaemias n MYC-HSR - neuroblastoma ERB-B in breast and ovarian cancersImportant oncogenes, their-mechanism of Activation and Associated Human Tumours 216-HMTypeONCOGENEAssociated human tumours1. Growth factors GFsi PDGFGlioblastoma ii TGF-aSarcoma iii FGFCa-bowel, breast2. Receptors for GFsi ERB-B,Squamous cell Ca ii HER2 a ERB2Ca breast, Ovary, stomach, lungs3. Signal transduction proteinsi RASCommon in 13 human tumours Ca lung, colon, pancreas, ii BCR-ABLCML, Acute leukaemia4. Nuclear regulatoryMYC TranslocatedBurkitts lymphomaTranscription proteinsMYC AmplifiedCa-lung, breast, colon5. Cell cycle regulatory proteinsCyclin DCa breast, liver, mantle cell lymphoma CDK4Glioblastoma, melanoma, sarcoma RB gene - Retinoblastoma, osteosarcoma BRCA 1 and 2 - Ca breast, ovary 