<prompt> In multiple myeloma following are seen -Increase CalciumBone painRenal failureAll of the above  <response>: In multiple myeloma ,hypercalcemia occurs due to destruction of bone. Bone pain is the most common symptom.The pain usually involves the back ribs. Pathological fracture may occur causing localised pain.Bone pain results from the proliferation of tumour cells in the marrow activation of osteoclasts which destroy the bone. Renal failure occurs due to hypercalcaemia, glomerular deposits of amyloid,hyperuricaemia, infiltration of kidney by myeloma cells.Reference:Harsh mohan textbook of pathology sixth edition pg no 383. 