<prompt> Which of the following situations will lead to increased viscosity of blood -Fasting stateHypoglycemiaMultiple myelomaAmyloidogenesis  <response>: Ans. is c i.e., Multiple Myeloma In multiple myeloma M proteins increase in the blood, this may cause cryoglobulinemia which leads to increase in viscosity of the blood.Viscosity of the blood depends uponHematocritComposition of the plasmaHematocrit - percentage of the volume of the blood occupied by red blood cells.Increase in hematocrit e.g. Polycythemia - Increase in viscosityDecrease in hematocrit e.g. Anemia - Decrease in viscosityComposition of the plasma - Composition of the plasma depends upon the presence of plasma proteins such as immunoglobulins and the resistance of the cells to deformation.Increase in plasma protein immunoglobulin - Increase in viscosity e.g. multiple myelomaIncrease in resistance of cells to deformation - Increase in viscosity e.g. hereditary spherocytosis 