<prompt> True about fibronectin nephropathy are all except:Autosomal recessive inheritanceGlomerular enlargement with PAS trichrome mesangial depositGlomerulus do not consistently stain for Ig and complementUltrastructural feature is presence of large electron dense mesangialorsubendothelial deposit  <response>: Ans. a Autosomal recessive inheritanceRef: Rosai 10thpg 1153Fibronectin glomerulopathyDefinitionCharacterized by massive fibronectin deposition in the glomeruli.Genetic basisCaused by mutations of FN1 gene on chromosome 2q34InheritanceHereditary autosomal dominant option A disease; Both sexes are equally affectedClinical featuresProteinuria nephrotic range, microscopic hematuria slow deterioration of renal function over a period of several years.Light microscopy Glomeruli appear enlarged lobulated with minimal degree of hypercellularity Most characteristic feature: marked enlargement of mesangium subendothelial option D space due to deposition of a homogeneous PAS ve, Congo red -ve option B materialElectron microscopyDense granular appearance of the deposit in mesangium or subendotheliumImmunohisto-chemical studies Strong positivity for fibronectin in the areas corresponding to the deposits. Scanty immunoglobulins complement factors may occasionally be seen, inconsistently. option CPrognosisPoor prognosisRecurrence after renal transplantThe disease has been reported to recur after renal transplantation. 