<prompt> SLE is which type of hypersensitivity reaction: March 2005Type I hypersensitivityType II hypersensitivityType III hypersensitivityType IV hypersensitivity  <response>: Ans. C: Type III hypersensitivity Type III hypersensitivity response Immune-complex mediated response Examples are: Some form of glomerulonephritis Serum sickness Ahus reaction SLE Antinuclear antibody ANA testing and anti-extractable nuclear antigen anti-EN A form the mainstay of serologic testing for SLE. Several techniques are used to detect ANAs. Clinically the most widely used method is indirect immunofluorescence. The pattern of fluorescence suggests the type of antibody present in the patients serum. ANA screening yields positive results in many connective tissue disorders and other autoimmune diseases, and may occur in normal individuals. Subtypes of antinuclear antibodies include anti-Smith and anti-double stranded DNA dsDNA antibodies which are linked to SLE and anti-histone antibodies which are linked to drug-induced lupus. Anti-dsDNA antibodies are highly specific for SLE; they are present in 70 of cases, whereas they appear in only 0.5 of people without SLE. The anti-dsDNA antibody titers also tend to reflect disease activity, although not in all cases. 