<prompt> Adverse effects of INH are all EXCEPTPeripheral neuritisHepatitisHypothermiaAcne  <response>: C Hypothermia Adverse effects INH is well tolerated by most patients. Peripheral neuritis and a variety of neurological manifestations paresthesias, numbness, mental disturbances, rarely convulsions are the most important dose dependent toxic effects. These are due to interference with utilization of pyridoxine and its increased excretion in urine. Pyridoxine given prophylactically 10 mgday prevents neurotoxicity even with higher doses, but routine use is not mandatory. INH neurotoxicity is treated by pyridoxine 100 mgday. Hepatitis, a major adverse effect of INH, is rare in children but more common in older people and in alcoholics It is due to dose related damage to liver cells and is reversible on stopping the drug. Other side effects are rashes, fever, acne and arthralgia. 