<prompt> Anticentromere antibodies are most commonly associated with :Diffuse cutaneous systemic sclerosisMixed connective tissue diseaseCREST syndromePolymyositis  <response>: Answer is C CREST syndrome: Anticentromere antibodies are characteristic of CREST syndrome. Anticentromere antibodies are present in 40 - 80 of patients with limited cutaneous scleroderma or crest syndrome. Anticentromere antibodies are found in only about 2 to 5 of patients with diffuse cutaneous scleroderma, and rarely in other connective tissue disease.- 