<prompt> Factors responsible for cardiovascular effects of non depolarizing neuromuscular blockers:-Histamine releaseEffects mediated by autonomic nicotinic cholinergic receptorsPancuronium produced a profound vagolytic responseAll of the above  <response>: All benzylisoquinoline except cisatracurium causes histamine release - BP HR - CVS Effects mediated by autonomic nicotinic Cholinergic receptor ex. Pancuronium vagal blockade BP HR Pancuronium produced a profound vagolytic response characterized by tachycardia, reduction in hea rate variability and baroreflex sensitivity . 