<prompt> The first sign of pubey in female isTanner stage ITanner stage IIPubic hairAxillary hair  <response>: Thelarche is the first sign of pubey in a girl around the age of 10 yearsDefinition:- beginning of secondary Postnatal breast development at the onset of pubey in girlsTanner stage 2 breast development.Because of rising level of estradiol.Breast development in a male is termed as gynecomastia, not thelarcheRefer: Nelsons Textbook of Pediatrics, SAE, 1st edition, pg no. 926 