<prompt> True about Atosiban:is an oxytocin receptor antagonistis an progesterone receptor antagonistis least effective in inhibiting preterm uterine contractionsis a anti-tocolytic drug  <response>: Ans. a is an oxytocin receptor antagonist. Ref. KDT, Pharmacology, 6th ed., p 323ATOSIBAN Atosiban is an oxytocin receptor antagonist with high uterine specificity. It is effective in inhibiting preterm uterine contractions, and is at least as effective as conventional beta-agonist therapy in treating preterm labour, but with significantly fewer maternal and fetal side effects. The incidence of maternalfetal side effects is significantly higher with beta-agonists, and serious maternal CV side effects, such as pulmonary edema and myocardial ischemia, were also associated with beta-agonist but not atosiban therapy. The favourable safety profile of atosiban in combination with equivalent tocolytic effectiveness would appear to represent an advance over current tocolytic therapy. Sr .no.Tocolytic Agents Comments1IsosuprineSE--hypotension, pulmonary edema, ARDS, hypokalaemia, hyperglycemia.2RitodrineSE-hypotension, pulmonary edema, ARDS, hypokalemia, hyperglycemiaQ3Salbutamol-4Ethanol-5MgSO4 UP 2002- Monitor respiration, urine output and deep reflexes.- Antidote is calcium gluconate.- Therapeutic levels 4-7 mEqL6AspirinProstaglandin inhibitor7Nifedipine-8AtosibanOxytocin analogue,oxytocin receptor antagonist - Counteracts effects of endogenous oxytocin.9Sodium nitroprussideNitric oxide donor, increases cGMPQ10Potassium channel opener 