<prompt> Auto antibody specific for SLE -ds DNAAnti ROAnti-topoisomeraseAntihistone  <response>: A ds DNA 127-Robbins 9thSelected autoantibodies associated with presumed autoimmune diseaseAutoantibiody SpecificityMajor Disease Association sLikely Roles in DiseaseAnti-ds DNA Double-stranded DNASLEFormation of immune complexesAnti-Sm ribonuclear core protein, Sm antigenSLE Formation of immune complexesAnti-RNP UI ribonuclear protine SLE, mixed connective tissue diseaseFormation of immune complexesAnti-SS-A Ro, anti-SS-B LA ribunucleoproteinsSjorgen syndrome, SLERole in Sjogren syndrome not knownAnti-Sci-70 DNA topoisomerase 1Systemic sclerosisUnknownAnti-histones histone proteinsSLE Drug InducedFormation of immune complexesAnti-centromere centromere proteinsLimited scieroderma, systemic sclerosisUnknownAntiphospholipid phospholipid- protien complexes involved in blood coagulationAntiphospholipid syndrome, SLEThrombotic episodesAnti-Jol Histidyl tRNA ligaseInflammatory myopathiesUnknownAnti-mitochondrialPrimary biliary cirrhosisUnknownAnti-eTg transglutaminaseDermatitis herpetiformisUnknownAnti-neutrophil cytoplasmic antibody ANCA proteins in neutrophil cytoplasmVarious vasculitidesFormation of immune complexNeutrophil degranulationAnti-smooth muscleChronic autoimmune hepatitisUnknownEach antibody specificity is detected in 30 to 90 of patients with a particular disease. Asterisks indicate high correlation between the antibody the antibody specificity and the disease. SLE is characterized by bewildering array of autoantibodies, particularly antinuclear antibody. Best screening test for SLE is demonstration of antinuclear antibody. ANCA antibody with peripheral rim distribution is seen in - Anti double stranded DNA. Libman-sach-endocarditis is seen in SLE. c-ANCA is typical of Wegners granulomatosis. p-ANCA is found in most cases of microscopic polyangitis and Chrug-Strauss syndrome. Perinuclear localization P-ANCA where in most of the autoantibodies are specific for myelo-peroxidase MPO.According to the WHO six patterns of mutually merging renal lesions are seen in lupus nephritis1. Minimal lesion2. Mesengial lupus nephritis3. Focal segmental LN4. Diffuse proliferative LN5. Membranous LN6. Sclerosing LNShrinking Lung Syndrome seen in SLE. 