<prompt> The principle cell in granulomaFibroblastEpithelioid cellGiant cellPlasma cell  <response>: Ans. b Epithelioid cellRef: Anderson 10th ed pg 583Macrophages also known as histiocytes are the cells that define a granulomaThe macrophages in granulomas are often referred to as epithelioidEpithelioid macrophages differ from ordinary macrophages in that they have elongated nuclei that often resemble the sole of a slipper or shoe.These changes are thought to be a consequence of activation of the macrophage by the offending antigen. 