<prompt> GIIbIIIa antagonist are all except -AbciximabClopidogrelTirofibanEptifibatide  <response>: Ans. is b i.e., Clopidogrel Glycoproteins Ilb 111a inhibitors o The platelet glycoprotein mediates platelet aggregation binding of adhesive proteins such as fibrinogen and Von Willebrand factor. o GP IIb Illa inhibitors, inhibit platelet aggregation by blocking GPI lb Ella. o They are more complete inhibitors than either aspirin or clopidogrel ticlopidinejj because they inhibit final pathway in platelet aggregation whether it is mediated by ADP or TXA2, while aspirin blocks only TXA2 pathway and clopidogrel blocks only ADP pathway. o Drugs are ? 1. Abciximab -- A humanized monoclonal antibody against GP IIb Ma. 2. Eptifibatide 3. Tirofiban -- Competitive inhibitors of GP IlbIIIa 4. Lamifiban o In addition to inhibiting Gp IIb Ma receptor, abciximab also inhibits a13, receptor which binds vitronectin and ocm32 a leukocyte integerin. This action is responsible for anti-inflammatory and antiproliferative propeies of abciximab. 