<prompt> Which of the following is an antiapoptotic gene -C-mycP53bcl-2bax  <response>: Ans. is 6c i.e., bcl - 2 ProapopticAnti-apopticApaf-1 Apoptosis activating factor -1cytochrome CBakBaxBimAIFP53 geneCaspasesTNFRIFas FADD Fas associated death domainBH3 only proteins Bim, Bid, BadSmacDIABLOBcl-2BCl-XFLIPMcl-1IAPsClinical importance of these genes.Inhibition of apoptosis results in uncontrolled cell proliferation and cancer,o Human papilloma virus and cervical cancer.P53 protein is proapoptotic gene, i.e., it induces apoptosis. HPV produce a protein E6 that binds and inactivates p53 - i Apoptosis - T Cell survival and growth - Cervical carcinoma.o EBVand B-cell lymphomaEBV produces a protein like BCL-2.BCL-2 inhibits apoptosis - B - cell lymphoma.Some other B-cell lymphomas also have high expression of BC1 - 2.o MelanomaIn this tumor, there is decreased expression of Apaf-1.Apaf-1 is an antiapoptotic protein, Its decreased expression induce apoptosis and malignancy.2. Ionizing radiations and cytotoxic drugs cause DNA damage and induce apoptosis via tumor suppressor gene p53 