<prompt> with worst prognosis-821 translocationInversion 16Normal cytogeneticsMonosomy 7  <response>: Monosomy 7 or paial deletion of the long arm of chromosome 7 7q- is a frequent cytogenetic finding in the bone marrow of patients with myelodysplasia MDS and acute myelogenous leukemia AML has worst prognosis Ref Davidson 23rd edition pg 789 