<prompt> Which of the following statements is true about steady state?It does not depend upon half lifePlasma concentration achieved is independent of dose rateLonger is dosing interval, lesser is the difference between peak and trough valuesRate of administration is equal to rate of elimination  <response>: Steady state is achieved when rate of administration is equal to rate of elimination Three impoant points to remember: Steady state is achieved within 4-5 half lives Dosing rate dose per unit time determines the average plasma concentration obtained at steady state. Frequency - drug when given intermittently, concentration will vary around baseline - peak and trough are obtained Longer interval - difference between peak and trough is more Lesser the interval - difference between peak and trough is less 