<prompt> A 70 year old alcoholic presents with abdominal pain, lump in the RUQ and weight loss. No history of upper or lower Gl symptoms. USG shows 10 x 10 cm mass in the right lobe of liver. Which serum marker will be helpful in diagnosis?Serum calcitoninCA19-9Alkaline phosphataseAlpha-fetoprotein  <response>: Answer: d Alpha-fetoprotein ROBBINS 9th ED, P-337A 70 year old chronic alcoholic with abdominal pain, weight loss lump in the RUQ suggests liver cancer. AFP is the tumor marker which is raised in liver cancerTUMOR MARKERSMarkersAssociated cancersNon neoplastic conditionsHuman chorionic gonadotropinTrophoblastic tumors, non- seminomatous testicular tumorsPregnancyCalcitoninMedullary carcinoma of thyroid a-fetoprotein AFPLiver ca, non-seminomatous testicular germ cell tumors especially yolk sac tumorsCirrhosis, hepatitisCarcinoembryonic antigen CEACancer of colon, pancreas, lung, stomach, heartPancreatitis, hepatitis, smoking, inflammatory bowel diseaseCA-125Ovarian cancer, some lymphomasMenstruation, peritonitis, pregnancyCA-19-9Colon, pancreatic breast cancer, CholangiocarcinomaPancreatitis, ulcerative colitis Cholangitis, patients who lack the Lewis blood type antigenCA-15-3,CA 27-29Breast cancer S-100, HMB-45Melanoma CD 30Hodgkins disease, Anaplastic large cell carcinoma CD25Hairy cell leukemia Adult T-cell leukemia 