<prompt> Mechanism of action of duloxetine is ?Selective Inhibition of serotonin reuptakeSelective inhibition of nor-epinephrine reuptakeSelective inhibition of both serotonin and nor-epinephrine reuptakeNone of the above  <response>: Ans. C. Selective inhibition of both serotonin and nor-epinephrine reuptakeDuloxetine, is a drug classified under serotonin-norepinephrine reuptake inhibitors sNRJs.At lower doses it is more prominent serotonin reuptake inhibitor.Whereas at higher doses it is more prominent inhibitor of nor-epinephrine reuptake.It has minimal dopamine agonist action. 