<prompt> What is true about HistoplasmosisIn late stage it is indistinguishable from TBCulture is not diagnosticHyphal forms are infectious formPerson to person spread occurs by droplet infection  <response>: Chronic late stages - Cavitary histoplasmosis so indistinguishable from T.B 1. Histoplasmosis or Darlings disease is caused by dimorphic fungus - Histoplasma capsulatum. 2. Transmission: By inhalation of spores i.e. microconidia circulating in the air being contaminated with soil. 3. Clinical Manifestations: - Pulmonary histoplasmosis: It is the most common form. Acute form stas as mild flu like illness Chronic - Cavitary histoplasmosis Mucocutaneous oral lesion paicularly seen in Indian patients Disseminated histoplasmosis develops if CMI is very low HIV. 4. Histoplasma is a dimorphic fungus, hence Culture is the gold standard method of diagnosis 