<prompt> Self-inflicted bites are seen in:Lesch-Nyhan syndromeFriese Maria syndromeCockayne syndromeBrodie syndrome  <response>: Lesch-Nyhan syndrome:Inherited X-linked recessive disorder, affects only males.Enzyme defect hypoxanthine guanine phosphoribosyl transferase HGPRTCharacterized by excess production of uric acid leading to GOUT.Self-mutilation bite their fingers and lips.Neurological abnormalities like mental retardation, aggressive behavior, learning disability occur.Neurological symptoms may be due to dependence of brain on the salvage pathway.Nephrolithiasis leads to renal failure. 