<prompt> Which one of the following drugs is associated with the development of a lupus-like syndrome, especially in patients identified as slow acetylators?ArniodaroneClonidineNitroglycerinProcainamide  <response>: Procainamide is metabolized by N-acetyltransferase a phase II drug metabolism reaction to form N-acetyl-procainamide NAPA, which itself has antiarrhythmic activity. Patients who are classified as slow acetylators may develop SLE-like symptoms when treated with procainamide. Other drugs metabolized via N-acetyltransferase, including isoniazid and hydralazine, have also been associated with lupus-like symptoms in slow acetylators. 