<prompt> In a case of anisocoria, when 1 pilocarpine le is instilled into the eye with abnormally dilated pupil, no response occurs. Cause of anisocoria may be:Adies pupilHorners syndromePharmacological blockageUncal herniation  <response>: Ans is c i.e. Pharmacological blockage Anisocoria inequality of pupillary size implies disease of the efferent motor nerve of the light reflex, iris or muscles of the pupil.If, on application of pilocarpine 1 in each eye, the affected pupil reacts little or not at all and the unaffected pupil constricts normally, the pupil is not dilated because of innervation problems but because of a problem in the sphincter muscle, itself. Non-neuronal causes of mydriasis are:Anticholinergic mydriasis e.g., scopolamine hyoscine, cyclopentolate, atropine.Traumatic iridoplegia sphincter rupture, pigment dispersion, angle recession.Angle-closure glaucoma ischemia of the iris sphincter.Fixed pupil after anterior segment surgery.Bound down iris synechia after iritis. 