<prompt> Multiple myeloma on radionuclide scanning presents asCold noduleHot noduleDiffuse increased uptakeDiffuse decreased uptake  <response>: Hot spots or distribution is seen inBone tumor or cancerBone metastasis from breast, lung, prostate, thyroid kidney.Fracture, when it cannot be seen on a regular X-ray Bone injections osteomyelitisCause of bone pain.Metabolic disorders such as osteomalacia, renal osteodystrophy, primary hyperparathyroidism, osteoporosis, complex regional pain syndrome Pagets disease.Refer: Suttons Textbook of Radiology Imaging, 7th edition, pg no:1251-1255 