<prompt> RBC transketolase deficiency is seen inThiamine deficiencyFolic acid deficiencyAnaemiaVitamin B12 deficiency  <response>: A Thiamine deficiency TRANSKETOLASE is an enzyme of both the pentose phosphate pathway. Transketolase activity is decreased in deficiency of thiamine, which in general is due to malnutrition. Two diseases are associated with thiamine deficiency: beriberi and Wernicke-Korsakoff syndrome. Red blood cell transketolase activity is used in the diagnosis of Wernickes encephalopathy and other B1-deficiency syndromes if the diagnosis is in doubt. 