<prompt> Groove sign is seen in-SyphilisDermatomyositisLGVSLE  <response>: Ans. is c i.e., LGV Groove sign of Greenblatt is pathognomonic of LGV secondary stage - when inguinal lymph nodes are enlarged, they are separated by Pouparts ligment, producing a groove.Lymphogranuloma venerum lymphogranuloma inguinale LGV is caused by chlamydia trachomatis, serotypes LI, L2, L3. Serotype L2 is the most common cause. The clinical course of LGV consist of following three stages : -i First stage Primary LGV: - Self limited, Single, asymptomatic, painless, non bleeding genital ulcer.ii Secondary stage: - Painful inguinal lymphadenopathy Remember - Ulcer is painless but lymphadenopathy is tender painful. Swollen lymph nodes coalesce to form bubos, i.e., matted lymph nodes. Buboes may rupture to form discharging sinus. Grooves sign - Enlarge lymph nodes both above and below inguinal ligament.iii Tertiary LGV genitorectal syndrome: - Characterized by proctocolitis.Complications of LGV Esthiomene - Enlargement, thickening and fibrosis of labia. Elephantiasis of the genitals Rectal stricture Systemic - Arthritis, pneumonitis, Perihepatitis 