<prompt> Mechanism of action of metoclopramide:Increase the lower esophageal sphincterDecrease the acid secretionIncrease gastric peristalsisUlcer healing agent  <response>: Ans. A. Increase the lower esophageal sphincterMetoclopramide is prokinetic drug. It acts on D2 and 5Ht3 receptor. There is increase in acetylcholine level and there is increase in LES and gastric motility. 