<prompt> HLA - B27 is associated with -Ankylosing spondylitisRheumatoid arthritisChronic active hepatitisDiabetes  <response>: A variety of diseases have been found to be associated with certain HLA alleles.The best know is the association of HLA-B27 with ankylosing spondylitis AS, individuals who inherit this allele have a 90 fold greater chance of developing AS than those who are negative for HLA - B27. 