<prompt> Defect seen in Di George syndrome: September 2009Humoral immunityCell mediated immunityThymic hyperplasiaAutoimmune hemolytic anaemia  <response>: Ans. B: Cell mediated immunity DiGeorge anomaly DGA is a congenital immunodeficiency characterized by abnormal facies; congenital hea defects; hypoparathyroidism with hypocalcemia; cognitive, behavioral, and psychiatric problems; and increased susceptibility to infections. Pathological hallmarks include conotruncal abnormalities and absence or hypoplasia of thymus and parathyroid glands. Thymic hypoplasia or aplasia leading to defective T-cell function cell mediated immunity is the hallmark of DiGeorge anomaly Microdeletion of chromosome 22 accounts for more than 90 of cases of DiGeorge anomaly. Deletions of chromosome 22q11.2 are found in the vast majority of patients with DiGeorge anomaly 