<prompt> Hera lal 35 years old man was found ve for HBsAg HBeAg, accidentally during screening of blood donation. On Lab examination SGOT SGPT are Normal. What should you do next :Liver biopsyInterferon therapyObservationHBV-DNA estimation  <response>: Answer is D HBV-DNA estimation Like Hbe Ag, serum HBV DNA is an indicator of HBV replication, but tests for. HBV DNA are more sensitive and quantitative- Harrison 161h1832 The marker HBV DNA is useful in following the course of HBV replication and thus deciding need for antiviral chemotherapy. Interferon therapy would be staed after adjudging its need as indicated by HBV DNA testing. Liver biopsy would be too radical at this stage. 