<prompt> Best method to diagnose typhoid in the first week is ?Blood cultrueBone marrow cultrueUrine cultureStool culture  <response>: Blood, intestinal secretions vomitus or duodenal aspirate, and stool culture results are positive for S typhi in approximately 85-90 of patients with typhoid fever who present within the first week of onset. They decline to 20-30 later in the disease course Ref Harrison20th edition pg 1079 