<prompt> Second gas effect is seen withEtherNitrous oxideHalothaneIsoflurane  <response>: The second gas effect is a distinct phenomenon that occurs independently of the concentration effect. The ability of the large-volume uptake of one gas first gas to accelerate the rate of increase of the Pa of a concurrently administered companion gas second gas is known as the second gas effect. For example, the initial large volume uptake of nitrous oxide accelerates the uptake of companion gases such as volatile anesthetics and oxygen. Basics of Anaesthesia 7e pg: 99 