<prompt> Major source of estrogen in postmenopausal women is:Peripheral conversion of androstenedioneSecretion from adrenalsTestosterone from the ovaryHRT  <response>: All postmenopausal and symptomatic per menopausal women who do not have contraindication particularlyThose with high risk factors osteoporosis.Those with premature menopauseEvaluation before starting HRT:History-personal, medical, gynecological, familyExamination -HT, wt., BMI, BP, breast, vaginal examinationPap smearMammographyLipid profileTransvaginal sonography-endometrial thicknessWork up relevant to symptoms, e.g. urinary continence, carbohydrate intolerance, psychoemotional states.Contraindications of HRT:PregnancyCA breastCA endometriumUndiagnosed abnormal vaginal bleedingActive liver diseasePresent deep vein thrombosis, thromboembolic disorderInvestigation not routinely needed before starting HRTEndometrial sampling-Only done if history of abnormal vaginal bleeding, TVS shows endometrial thickness 5 mm.Serum FSH-Only done if diagnosis of menopause is not clear, e.g. vasomotor symptoms in absence of amenorrhoeaBone densitometry-Using DEXA dual energy X-ray absorptiometry oflumber vertebrae, hip bone for women with risk factors for osteoprosis, persistent backache, bone aches, history of recent fracture, for research purpose 