<prompt> Which of the following are features of opioid withdrawal?Constipation, bradycardia, comaAbdominal cramps, vomiting, insomniaHypehermia, vomiting, restlessnessHypothermia , nausea , constipation  <response>: - Physical dependence on morphine usually requires about 25 days to develop but may occur sooner in emotionally unstable persons. - When physical dependence is established, discontinuation of opioid agonist produces a typical withdrawal abstinence syndrome. - Initial symptoms of withdrawal include yawning, diaphoresis, lacrimation, or coryza. - Insomnia restlessness are prominent. - Abdominal cramps, nausea, vomiting diarrhea reach their peak in 72 hours then decline over the next 7 to 10 days. - During withdrawal, tolerance to morphine is rapidly lost syndrome can be terminated by a modest dose of opioid agonist. 