<prompt> Which of the following substances is a growth factor that is capable of inducing all the steps necessary for angiogenesis?. EGFTGF -aPDGFBasic fibroblasts growth factor  <response>: Basic fibroblast growth factor FGF Growth factors are chemicals that are associated with cell growth. For example, fibroblast growth factor FGF can induce the growth and proliferation of fibroblasts. Additionally, one type of FGF, basic FGF, is capable of inducing all of the stages of angiogenesis basement membrane and extracellular matrix degradation, endothelial migration, endothelial proliferation, and endothelial differentiation. The epidermal growth factor family includes epidermal growth factor EGF and transforming growth factor alpha TGF- alpha. These substances can cause proliferation of many types of epithelial cells and fibroblasts. The EGF receptor is c-erb B1. Platelet-derived growth factor PDGF, which is found in platelets, activated macrophages, endothelial cells, and smooth muscle cells, can cause migration and proliferation of fibroblasts, smooth muscle cells, and monocytes. TGF- beta, produced by platelets, endothelial cells, T cells, and macrophages, is associated with fibrosis. In low concentrations it causes the synthesis and secretion of PDGF, but in high concentrations ii. inhibits growth due to inhibition of the expression of PDGF receptors. 