<prompt> Peau dorange appearance is due to -Intra-epithelial cancerSub-epidermal cancerLymphatic permeationVascular embolization  <response>: Phenomena resulting from lymphatic obstruction in advanced breast cancer1. Peaud orange Peau d orange is due to cutaneous lymphatic edema, where the infiltrated skin is tethered by the sweat ducts, it cannot swell, leading to an appearance like orange skin. Occasionally it may be seen in a chronic abscess. 2. Cancer-en-cuirasse Is infiltration of the skin with carcinoma3. Lymphangiosarcoma Its a rare complication of lymphodema with an onset many years following the treatment.It takes the form of multiple subcutaneous nodules in the upper limb and must be distinguished from recurrent carcinoma of the breast. 