<prompt> Cullens sign is seen in: March 2013Acute cholecystitisAcute pancreatitisAcute hemorrhagic pancreatitisBlunt injury abdomen  <response>: Ans. C i.e. Acute hemorrhagic pancreatitis Cullens sign It is superficial edema and bruising in the subcutaneous fatty tissue around theumbilicus. It is named for Thomas S. Cullen 1869-1953, an obstetrician who first described the sign in ruptured ectopic pregnancy in 1916. This sign takes 24-48 hours to appear and can predict acute pancreatitis, with moality rising from 8-10 to 40. It may be accompanied by Grey Turners sign bruising of the flank, which may then be indicative of pancreatic necrosis with retroperitoneal or intraabdominal bleeding. 