<prompt> Hoffmans elimination is seen with:AtracuriumPancuroniumSuxamethoniumRocuronium  <response>: Ans: A Atracurium Ref: Mi Her text hook of Anaesthesia. 6th edition.ExplanationAtracuriumAtracurium and eisatracuriuni stereoisomer of atracurium are the only two drugs metabolized by Hoffman eliminationAtracurium is a short acting non-depolarizing neuromuscular blockerAtracurium is metabolized by Non-specific esterases Hoffmans elimination, independent of renal and hepatic metabolismHence Drug of choice in hepatic and renal failureHoffmans eliminationIt is the spontaneous non-enzymatic chemical breakdown at physiologic PH and temperatureHoffmans elimination of atracurium gives a metabolite called laudanosine which can precipitate seizuresIt triggers the release of histamine leading to hypotension, tachycardia bronchospasmDosage - 0.5mgkg See the following table AtracuriumCisatracuriumstereoisomer of AtracuriumPotencyLessMoreNon specific ester hydrolysisYesNoHoffman eliminationYesYesMetabolite - LaudanosheQuantity producedMoreLessCNS toxicity seizuresYesNoHistamine releaseYesNo 