<prompt> In sickle cell anemiaGlutamate replaces valineValine replaces glutamateValine replaces aspaateAspaate replaces valine  <response>: Sickle cell anemia is caused by mutation in the beta globin chain, that changes the amino acid glutamate to valine in the 6th position of beta globin chain of HbRef: Textbook of medical physiology by N Geetha, 3rd edition, page no. 94 