<prompt> PPIs are use used inZE syndromeNSAIDs induced peptic ulcerGastroesophageal refluxAll of the above  <response>: Ans. isdi.e., All of the above PPI are the DOC for peptic ulcer gastric or duodenal, GERD, ZE syndrome, prevention of aspiration pneumonia and NSAID induced gastric duodenal ulcers. Note - PGEI analogue Misoprostol is specific drug for prevention and treatment of NSAID induced ulcer, but DOC is PPI. 