<prompt> case history of peripheral smear is showing hypersegmented neutrophils , this is due to deficiency ofvit B12 deficiencyfolate deficiencyiron deficiencythalasemia  <response>: Neutrophil hypersegmentation can be defined as the presence of neutrophils whose nuclei have six or more lobes or the presence of more than 3 of neutrophils with at least five nuclear lobes. ... The presence of hypersegmented neutrophils is an impoant diagnostic feature of megaloblastic anaemias. ref : robbins 10th ed 