<prompt> Congenital lactic acidosis occur due to the deficiency of which of the following enzyme?TransketolasePyruvate dehydrogenase enzyme complexPyruvate kinasePyruvate decarboxylase  <response>: Inherited pyruvate dehydrogenase deficiency, presents with lactic acidosis. Due to lack of pyruvate dehydrogenase,there will be lack of Acetyl co A production and pyruvate to lactate conversion occurs leading to accumulation of lactic acid Causes of lactic acidosis: 1. Tissue hypoxia 2. Mitochondrial disorders 3. Deficiency of: PDH Enzyme TCA cycle enzymes Vit B1 4. Poisoning : Cyanide, Mercury, Arsenite Reference: Harpers Illustrated Biochemistry 30th Edition Page no: 174 