<prompt> Aseptic loosening in cemented total hip replacement, occurs as a result of hypersensitivity response to:Titanium debrisHigh density polythene debrisN. N-Dimethyltryptamine DMTFree radicals  <response>: B i.e. High density polythene debris Paicles of metal titanium, nickel, chromium etc, cement PMMA and polyethylene all can produce periprosthetic osteolysis aseptic loosening ; but because they are most numerous polyethylene paicles appear to be the major culpritQ. 