<prompt> In which of the following carcinomas of breast, loss of E-cadherin plays a vital role in pathogenesis?Pagets diseaseDuctal carcinomaLobular carcinomaMedullary carcinoma  <response>: The main pathogenesis underlying Lobular carcinoma is accquired loss of the tumor suppressive adhesion protein E-cadherin, also called as CDH-1. 