<prompt> A patient presents with seizures, adenoma sebaceum and mental retardation. What is the diagnosis?Sturge Weber syndromeTuberous sclerosisNeurofibromatosisNeurocysticercosis  <response>: B Tuberous sclerosis In 1908 Vogt set forth the triad of intractable epilepsy, mental retardation, and adenoma sebaceum represents Hallmark of tuberous sclerosis complex TSC to most clinicians Major features: Facial angiofibromas or forehead plaque Nontraumatic ungual or periungual fibroma Hypomelanotic macules 3 Shagreen patch connective tissue nevus Multiple retinal nodular hamartoma Cortical tuber: When cerebellar cortical dysplasia and cerebral white matter migration tracts occur together, they should be counted as one rather than two features of tuberous sclerosis. Subependymal nodule Subependymal giant cell astrocytoma Cardiac rhabdomyoma, single or multiple Lymphangioleiomyomatosis: When both lymphangioleiomyomatosis LAM and renal AMLs are present, other features of tuberous sclerosis should be present before a definite diagnosis is assigned. As many as 60 of women with sporadic LAM and not TSC may have a renal or other AMLs. Renal AML: When both LAM and renal AMLs are present, other features of tuberous sclerosis should be present before a definite diagnosis is assigned see previous remarks. Minor features Multiple randomly distributed pits in dental enamel Hamartomatous rectal polyps: Histologic confirmation is suggested. Bone cysts: Radiographic confirmation is sufficient. Cerebral white matter radial migration lines: Radiographic confirmation is sufficient. One panel member felt strongly that 3 or more radial migration lines should constitute a major sign. Gingival fibromas Nonrenal hamartoma: Histologic confirmation is suggested. Retinal achromic patch Confetti skin lesions Multiple renal cysts: 