<prompt> If the first child is heterozygous and the wife is homozygous for an autosomal-recessive gene, what will be the outcome?75 children affectedNo child affected, but all are carriers50 children affected, rest are carriers25 children affected, rest are carriers  <response>: If the husband is heterozygous and the wife is homozygous for an autosomal recessive gene, 50 of the children will be affected; the rest will be carriers. This is pseudo-dominant inheritance, which refers to the observation of apparent dominant parent to child transmission of a known autosomal-recessive disorder, or it can also mean the inheritance of a recessive trait mimics a dominant pattern. This occurs when a homozygous affected individual has a paner who is a heterozygous carrier, and their children have 1 in 2 chance to get affected 50 Ref: Nelson textbook of pediatrics 21st edition Pgno: 645 