<prompt> In cholangitis, the organism mostly responsible isE.coliStreptococcusE.histolyticaClostridium  <response>: Ascending bacterial infection of the biliary ductal system with obstruction Most common cause is choledocholithiasis Most common organisms present in the bile in patients with cholangitis : E.coli MC. Klebsiella pneumoniae, streptococcus faecalis Bacteroides fragilis Ref: Sabiston 20th edition Pgno :1507 