<prompt> Which of the following can be givenorally -Cytosine araActinomycin DDoxorubicinMesna  <response>: Ans. is d i.e., Mesna o MESNA is given alongwith alkylating agents to prevent nephrotoxicity due to cyclophosphamide. o It can be administered intravenously or orally. Cytarabine Cytarabine Ara C is degraded by the enzyme cytidine deaminase. Cytidine deaminase is present in high concentrations in g.i. tract therefore only about 20 of the drug reaches the circulation after oral Ara-C administration. Thus the drug must be given intravenously. Dactinomvcin or Actinomvcin D o It is administered by intravenous route. Doxorubicin It is administered intravenously and are cleared by complex pattern of hepatic metabolism and biliary excretion. 