<prompt> A 15-years-old boy presented with one day history of bleeding gum,subconjunctival bleed and purpuric rash. Investigations revealed followed results:Hb- 6.4 gmdi; TLC-26, 500mm3 platelet 35,000 mm3; prothrombin time-20 sec with a control of 13 sec; paial thromboplastin time-50sec; and Fibrinogen 10mgdL.Peripheral smear was suggestive of acute myeloblastic leukemia. Which of the following is the most likely?Myeloblastic leukemia without maturationMyeloblastic leukemia with maturationPromyelocytic leukemiaMyelomonocytic leukemia  <response>: Answer is C Promyelocytic Leukemia: Acute promyelocytic Leukemia APL characteristically presents with Thrombocytopenia, prolonged PT, Prolonged PTT, hypofibrinogenemia and increased levels offibrin degradation product as it is associated with a high incidence of DIC. The patient in question is presenting with an elevated PT, elevated PTT, Thrombocytopenia platelets 35,000 and decreased fibrinogen levels Normal fibrinogen levels 233-496 mgdl All these features are characteristic of DIC which is a common mode of presentation in APL. APL is the single best answer of choice. Characteristic presentation of APL Patients are typically younger than other subtypes of AML Patients typically present with bleeding tendencies andor DIC as DIC is common in APL Features of DIC Thrombocytopenia Prolonged prothrombin time PT Prolonged Paial Thromboplastin Time PTT Increased Fibrin Degradation products N0-1 ugml Decreased Fibrinogen levels N233-496 mgdl 