<prompt> Maximum dose of lignocaine with adrenaline is in mg kg42710  <response>: Ans. c 7. Ref. Harrisons Medicine, 18th735LIGNOCAINE Maximum safest dose 3 mgkg or 200 mg and with adrenaline 7 mgkg or 500 mg. Duration of effect 45 to 60 min and with adrenaline it is 2-3 hours. Should not be given in patients with history of malignant hyperthermia. Concentration usedo Surface topical analgesia- 4o As jelly, for urethra- 2o Nerve blocksepiduralinfiltration block-- 1-2o Spinal- 5 Lignocaine is an amide It is 4 times less potent than bupivacaine Drug of choice for lignocaine-induced arrhythmia is bretylium tosylate SGPGI 2002 Repeated doses of 4-5 mL of 0.5 bupivacaine or 1 lignocaine are used to maintain epidural analgesia. Transient neurological symptoms is an disntinct side-effect of LignocaineEducational point:The baricity of the local anesthetic solution. Baricity is defined by the ratio of the density of the local anesthetic solution to the density of CSF. A solution with a ratio 1 is hyperbaric and tends to sink with gravity within the CSF. An isobaric solution has a baricity of 1 and tends to remain in the immediate area of injection. A ratio 1 is a hypobaric solution, which rises in the CSF. 