<prompt> Which of the following drugs halts macrovascular as well as microvascular effects of DM?AcarboseBiguanidesMeglitinideAlgaliptin  <response>: Ans. is b i.e., Biguanides Biguanides Biguanides like metformin are the 1st line drugs for the treatment of Type 2 DM, which acts by AMPK activation. Advantages of Biguanides are as followsi Non hypoglycemic.ii Promotes weight loss.iii Prevents macro as well as microvascular complications of DM.iv No acceleration of p cell failure.v Reduction in glycosylated Hb, i.e., HbAlC by around 1.vi It has also found to improve fertility in PCOD patients. 