<prompt> Infliximab is directed against -Tumor necrosis factor-a TNF - aInterleukin-1 IL-1Interleukin -12 IL -12Intercellular adhesion molecule ICAM  <response>: TNF-alfa alpha inhibitors TNF-alpha are a group of medicines that suppress the bodys natural response to tumor necrosis factor TNF, a protein produced by white blood cells that is involved in early inflammatory events. TNF-alfa inhibitors treat a wide range of inflammatory conditions such as RA , juvenile ahritis, crohns disease, ulcerative colitis , ankylosing spondolytis, and psoriasis . Ref - Tripati 7th edition , Pubmed.com 