<prompt> Incomplete closure of ectodermal cleft is know to causeRetinal detachmentIridodonesisRetinoblastomaColoboma of iris and retina  <response>: Inderbir Singh;s Human embryology Tenth edition Pg 364 Failure of the choroidal fissure to obliterate completely may lead to deficiencies colobomaof various layers of eyeball including iris ciliary body and choroid 