<prompt> Which of the following agents is not used in the treatment of Diabetic Macular Edema Retinopathy-RuboxistaurimPyridazinonesBenfotiamineTamoxifen  <response>: Antivascular endothelial growth factor anti-VEGF Vascular endothelial growth factor VEGF plays a pivotal role in the etiopathogenesis of diabetic maculopathy and retinopathy. Anti-VEGFs when given intravitrealy in 0.1 ml vehicle lead to improvement in vision in 40 cases and stabilise vision in another 40 cases. They include : Ranibizumab Lucentis Pegaptanib Macugen Bevacizumab Avastin Ref; A.K.Khurana; 6th edition; Page no: 281,459 