<prompt> Which is the most impoant prognostic marker in ALL?Leucocyte count 50000HyperploidyResponse to treatmentOrganomegaly  <response>: Response to treatment is the most impoant prognostic marker in ALL. Leucocyte count 50000ul Poor prognosis Hyperploidy Favorable prognostic factor Response to treatment Remission status at 14 days of chemotherapy is best guide to prognosis. Organomegaly Poor prognosis. Lymph node, liver, spleen and testis enlargement indicate spread of cancer Unorable prognostic factors for ALL: Extreme age group: 1 year or 10 years Black males TLC1 laccu.mm Organomegaly CNS Leukemia L2 ALL, pre B cell and mature B cell ALL Hypoploidy t9:22 and t4:11 Remission 14 days 