<prompt> A couple with a family history of beta-thalassemia major in a distant relative has come for counseling. The husband has HbA2 of 4.8 and the wife has HbA2 of 2.3. The risk of having a child with beta-thalassemia major is:502550  <response>: HBA2 of 4.8 indicates beta thalassemia minor or trait.HbA2 of 2.3 indicates normal person.Thalassemia is an autosomal recessive disorder. Therefore, when a trait marries a minor, then the risk of having children with thalassemia major is 0. 