<prompt> Clomiphene acts to induce ovulation by wof mechanismsDiminishing ER-mediated negative feedback at the pituitaryIncreasing the action of ER a in the ovaryIncreasing the action of ER a in the hypothalamusIncreasing the amount of ER a  <response>: Antiestrogens Clomiphene citrate:- It binds to both ERa and ERb and acts as a pure estrogen antagonist.it induces Gn secretion in women by blocking estrogenic feedback inhibition of pituitary. The amount of LHFSH released at each secretory pulse is increased. In response, the ovaries enlarge and ovulation occurs if the ovaries are responsive to Gn. Adverse effects:- Polycystic ovaries, multiple pregnancy, hot flushes, gastric upset, veigo, allergic dermatitis. Risk of ovarian tumour may be increased. Ref:- kd tripathi; pg num:-312 