<prompt> Diagnosis of X linked Agammaglobulinemia should be suspected if:Female sexAbsent tonsils and no palpable lymph nodes on physical examinationHigh isohemagglutinins titersLow CD3  <response>: X-linked agammaglobulinemia Characterized by the failure of B-cell precursors pro-B cells and pre-B cells to develop into mature B cells. B cells are absent or markedly decreased in the circulation,and the serum levels of all classes of immunoglobulins are depressed. Pre-B cells, which express the B-lineage marker CD19 but not membrane Ig, are found in normal numbers in the bone marrow. Germinal centers of lymph nodes, Peyers patches, the appendix, and tonsils are underdeveloped. Plasma cells are absent throughout the body. T cell-mediated reactions are normal. 