<prompt> All of the following are true about Sickle cell disease, Except:Single nucleotide change results in change of Glutamine to ValineRFLP results from a single base changeSticky patch is generated as a result of replacement of a non polar residue with a polar residueHbS confers resistance against malaria in heterozygotes  <response>: C i.e. Sticky patch is generated as a result of replacement of a non polar residue with a polar residueIn sickle cell anemia- Glutamic acid is replaced by valine at sixth position in 3 - globin chainQ.Sticky patch is generated as a result of replacement of polar residue negatively charged glutamate amino acid with a nonpolar hydrophobic residue valineQ. This change makes HbS sickle cell hemoglobin less soluble, when deoxygenated and cause sicklingQ.HbS confers resistance against malaria in heterozygotesQ. 