<prompt> All are true regarding Toxoplasmosis, except ?Subclinical in most cases among adultsIntracerebral calcification in childrenIgM antibody in new born suggests congenital infectionNOT infective in 3 trimester in pregnancy  <response>: Ans. is d i.e., Not infective in third trimester in pregnancy . The incidence of transplacental infection is highest in third trimester but the infant is not severely affected. . The presence of IgM which does not cross placenta in the infants circulation is diagnostic. Clinical manifestation of toxoplasmosis 1. Adults a Immunocompetant host - Asymptomic in 90 of patients. - M.C. clinical featur is cervical lymphadenopathy. - Other less common manifestations are pneumonia, myocarditis, encephalitis. b Immunocompromised host - M.C. signs and symptoms are principally within CNS Encephalopathy, Meningoencephalitis. 2. Children a Congenital - May present with hydrocephalus, microcephaly mental retardation, deafness, blindness, epilepsy. - Intracerebral calcification may occur. b Acquired - Mostly asymptomatic - CFs are chorioretinitis most common, cataract, glaucoma. 