<prompt> A 70-year-old man presents with fatigue, weight loss, abdominal pain, and ove blood in the stools. A complete blood count reveals anemia with hemoglobin of 10 gdL. A colonoscopy and subsequent colonic biopsy reveal adenocarcinoma. Which of the following is the most likely predisposing lesiondisorder that lead to this malignancy?Tubular adenomaFAP syndromeHyperplastic polypHNPCC syndrome  <response>: The patient is most likely a case of sporadic colon cancer. Familial Adenomatous Polyposis FAP syndrome: Colorectal adenocarcinoma develops in 100 of untreated FAP patients, often before age 30 and nearly always by age 50. Hyperplastic polyps: These lesions are without malignant potential. Hereditary non-polyposis colorectal cancer HNPCC syndrome: Colon cancers in HNPCC patients tend to occur at younger ages than sporadic colon cancers and are often located in the right colon. Adenocarcinoma of colon Develops through a progression of mutations in oncogenes tumor suppressor genes in a multistep process. Normal mucosa evolves into tubular adenoma with malignant potential-carcinoma Adenoma-Carcinoma sequence Majority of sporadic colon cancers 70-80 follow this sequence and usually have cancers of left colon Rest of the sporadic cases have defects in DNA mismatch repair or DNA hypermethylation arise from serrated adenoma and develop more commonly in right colon. Carcinoma of rectosigmoid left-sided colon-Early obstruction, with change in bowel habits decreased caliber of stool. Carcinoma of right colon right-sided-Present late, with Iron deficiency anemia dt chronic blood loss from lesion. 