<prompt> One of the parents who have a child with Down syndrome, has a balanced translocation between chromosome 15 and 21. What advice will you provide to the couple to prevent a child being born with Down syndrome?Prenatal diagnosis and advice abortionArtificial insemination with donors spermAdoptionDoes not matter  <response>: a. Prenatal diagnosis and advice abortionRef: Nelsons 20e p 610-615Taking into view the chances of baby affected with Downs syndrome, prenatal diagnosis is advocated and abortion advised, if fetus is affected.Recurrence risk of Down syndrome, when a couple already has a child with Down syndrome depends on the karyotype of the affected child his parents:Karyotype of affected childKaryotype of parentsRecurrence riskFatherMotherTrisomy 21NN 1Translocation 21q21qNN 1Either parent carrierQ100NN 1Translocationother chr with chr 21carrierN1-3Ncarrier10-15 