<prompt> Intrinsic causes of hemolytic anemia are all except-HypersplenismG6PD deficiencyHereditary spherocytosisPyruvate kinase deficiency  <response>: Intrinsic causes of hemolytic anemias are due to defective RBCs which includes- Hereditary spherocytosis,Hereditary elliptocytosis, Hmp shunt enzyme deficiencyG6PD deficiency, glycolytic enzyme pyruvate kinase deficiency, thalassemia, sickle cell disease . While in hyper splenism RBCs are destroyed by sequestraion which is an extrinsic cause. Ref : Robbins pathologic basis of disease edition :9 pg 630 ; table 14-1 