<prompt> Gastrointestinal stromal tumours arise formPaneth cellsStave cellsEnterocytesInterstitial cells of Cajal  <response>: Gastrointestinal stromal tumours GISTs may arise in anypa of the gastrointestinal tract but 50 will be found inthe stomach.They are now known to be a distinct tumor derived from the interstitial cells of Cajal,The tumours are universally associated with a mutation in thetyrosine kinase c-kit oncogene CD 117. These tumours are sensitive to the tyrosine kinase antagonist imatinibBailey and Love 27e pg: 1139 