<prompt> Superantigens are -Erythrotoxin of staph. AureusCI. Difficile toxinStaphyloccocal toxic shock syndrome toxinCholera toxin  <response>: Superantigens are a class of antigens that cause non-specific activation of T-cells resulting in polyclonal T cell activation and massive cytokine release. Superantigens bind first to the MHC Class II and then coordinate to the variable alpha or beta chain of T-cell Receptors . Eg: S. Aureus enterotoxins, Group A streptococci pyrogenic exotoxin, HIVNef, Rabies virus nucleocapsid protein etc... Ref: Ananthanarayan Panikers textbook of microbiology 9th edition pg:90 