<prompt> Major contribution to cachexia with advanced cancer?ClathrinHistamineInterferonTumor-necrosis-factor TNT  <response>: Ans. is d i.e., Turnor-necrosis factor TNT Patients with cancer commonly suffer progressive loss of body fat which is accompnied by profound weakness anorexia, and anemia. This wasting syndrome is referred to as cachexia. o TNF produced by macrophages or some tumor cells is the most impoant mediator of cachexia. 