<prompt> Which of the following features isare suggestive of nehogrnic DI in comparison to central DI :Desmopressin nasal spray restore urine output to normal levelBasal vasopressin level 1 pgmlNormal posterior pituitary bright spot is not visible on MRI scanChange in water loss during fluid deprivation test  <response>: Ans: b. Basal vasopressin level 1 pgmlFailure to Produce ADH: Central Diabetes Insipidus.The treatment for central diabetes insipidus is administration of a synthetic analog of ADH, desmopressin, which acts selectively on V2 receptors to increase water permeability in the late distal and collecting tubules.Desmopressin can be given by injection, as a nasal spray, or orally, and it rapidly restores urine output toward normal.The polyuria anil polydipsia of nephrogenic DI are not affected by treatment ith standard doses of DDAVP. 