<prompt> The following statements regarding insulin resistance in diabetic patients are true except:It is more common with huminsulinIt may occur in the presence of infectionsIt may be due to antibodies to insulinUse of glucocorticoids may be useful in severe cases  <response>: Insulin resistance in diabetic patients has been defined as insulin requirement of more than 2 Ukgday for control of hyperglycemia or prevention of ketosis for more than 3 days in the absence of any complications. Stressful conditions when there is excess of glucocorticoids and other hyperglycemic hormones like trauma, surgery, and infections can oppose insulin action and produce short-term insulin resistance. In few patients, it may be due to development of antibodies of the IgG type to minor contaminants or to some components e.g. Zinc, protamine, etc., added to insulin, hence it is less commonly seen with purer preparations of insulin or with human insulin huminsulin. In case the resistance persists, a short-term course with prednisolone immunosuppressant may bring down the insulin requirement. 