<prompt> Effect of Potassium ionophore valinomycin on beta cells of pancreas is?Decrease the secretion of insulinInsulin secretion increasesC-peptide secretion increasesIncrease secretion of both insulin and C- peptide  <response>: a Decrease the secretion of insulinRef: stylefont-size: 1.04761904761905em; font-family: Times New Roman, Times, serif and eje-online. orgcontent881113Valinomycin interferes with the insulin releasing effect of glucose by increasing the potassium permeability of the B cell membrane.About ValinomycinIt is a member of the group of natural neutral ionophores because it does not have a residual charge. It is highly selective for potassium ions within the cell membrane and functions as a potassium-specific transporter. It facilitates the movement of potassium ions through lipid membranes down the electrochemical potential gradient. A very little literature is available regarding valinomycin.Theoretically, hyperpolarization of beta cells due to increased K permeability caused by valinomycin may lead to inhibition of insulin release depolarization is needed for insulin release from beta cells. 