<prompt> Absolute contraindication of HRT is?EndometriosisOsteoarthritisHeart diseaseBreast carcinoma  <response>: ANSWER: D Breast cancerREF: Harrisons 18th ed edition chapter 348Contraindications to HT should be assessed routinely and include unexplained vaginal bleeding, active liver disease, venous thromboembolism, history of endometrial cancer except stage 1 without deep invasion or breast cancer, and history of EURHD, stroke, transient ischemic attack, or diabetes.Relative contraindications include hypertriglyceridemia 400 mgdl and active gallbladder disease; in such cases, transdermal estrogen may be an option 