<prompt> Anti mitochondrial Ab seen typically in:Primary Biliary cirrhosisHepatitis BHepatitis CHepatitis A  <response>: Primary Biliary cirrhosis is a disease characterized by chronic inflammation and fibrous obliteration of intrahepatic bile duclioles due to an unknown primary stimulus. EtiologyPBC is believed to due to an autoimmune etiology as it is often associated with other auto immune disorders such as CRCST syndrome: Calcinosis, Raynauds phenomena, Esophageal dysmotility, Sclero-dactily. Telangiectasia Sicca syndromeAutoimmune thyroiditisRenal tubular acidosisAnti mitochondrial antibody IgG is positive Clinical featureMost patients arc asymptomatic.Pruritis is commonestearliest symptomJaundiceDeficiency of fat soluble vitamin due to malabsorption leads to:Vit D deficiency Bone painOsteomyelitis Vit K deficiency bleeding bruisingVit A deficiencyNight Blindness IXanthelisma and Xanthomas arc due to elevation of serum lipids.Lab findingIncreased Serum alkaline phosphates.Positive mitochondrial antibody sensitive and specific. 