<prompt> Basement membrane degeneration is mediated by -MetalloproteinasesOxidasesElastasesHydroxylases  <response>: Extracellular Matrix ECM comprises of interstitial matrix and basement membrane. The degradation of collagen and other ECM proteins is achieved by a family of matrix metalloproteinases MMPs which are dependent on zinc ions for their activity. MMPs include interstitial collagenases, which cleave fibrillar collagen MMP-1, -2 and -3 gelatinases MMP-2 and 9, which degrade amorphous collagen and fibronectin stromelysins MMP-3, -10, and -11, which degrade a variety of ECM constituents, including proteoglycans, laminin, fibronectin, and amorphous collagen. ref robbins pathology 9th ed page 105 