<prompt> Weight range of adrenal glands in most of cases of cushings disease is -4-11gm11-13 gm14-24 gm25-40 gm  <response>: Ans. is d i.e., 25-40 gm o The weight of adrenal gland depends on the cause of cushing syndrome : ? Due to ACTH production by pituatory microadenoma cushing disease or by ectopic ACTH production. o ACTH stimulates the zona reticularis and zona fasciculata which results in either diffuse hyperplasia 25-40 gm or nodular hyperplasia 30-50 gm of adrenal. Primary pituitary adenoma Weight is less than 30 gm. Primary pituitary carcinoma -4 Weight is 200-300 gm. Exogenous glucocoicoid administration o Exogenously administered glucocoicoids inhibit the release of ACTH from pituitary by negative feed back mechanism. o So, there is no stimulatory signal on zona fasciculata and zona reticularis -- Both these layers undergo atrophy. o As zona glomerulosa function is independent of ACTH, its thickness remains normal. o Due to atrophy the weight of the gland is less than normal, i.e., 4 gm. 