<prompt> High risk of malignancy is seen in?Simple hyperplasia with atypiaSimple hyperplasia without atypiaComplex hyperplasia with atypiaComplex hyperplasia without atypia  <response>: Answer is option3, complex hyperplasia with atypia Endometrial hyperplasia with atypia is the least common type of hyperplasia, but is the type most likely to progress to type 1 endometrial carcinoma 1-3 which accounts for 97 of uterine cancers, whereas simple hyperplasia rarely progresses to carcinoma. 