<prompt> In Beta thalassemia, there is -Increase in beta chain ,decrease in alpha chainDecrease in beta chain ,increase in alpha chainDecrease in beta chain ,decrease in alpha chainIncrease in beta chain, increase alpha chain  <response>: Beta thalassemias are caused by decreased rate of beta chain synthesis resulting in reduced formation of Hb A in the red cells. A deficiency of beta globin chains in beta thalassemia leads to excess of alpha chains within the developing red cells.Reference:Harsh mohan textbook of pathology sixth edition pg no 322. 