<prompt> Which of the following is not the component of Multien- zyme Fatty Acid Synthase Complex?Acetyl transacylaseEnoyl reductaseMalonyl transacylaseMonoamine oxidase  <response>: Ans. d Monoamine oxidase Ref. Harpers biochemistry 27th ed., Chapter 23FATTY ACID SYNTHASE COMPLEX IS A POLYPEPTIDE CONTAINING 7 ENZYME ACTIVITIES In mammals, the fatty acid synthase complex is a dimer comprising two identical monomers, each containing all seven enzyme activities of fatty acid synthase on one polypeptide chain. Initially, a priming molecule of acetyl-CoA combines with a cysteine - SH group catalyzed by acetyl transacylase. Malonyl-CoA combines with the adjacent - SH on the 4-phosphopantetheine of ACP of the other monomer, catalyzed by malonyl transacylase reaction 1b, to form acetyl acyl-malonyl enzyme. It is liberated from the enzyme complex by the activity of a seventh enzyme in the complex, thioesterase deacylase. The free palmitate must be activated to acyl-CoA before it can proceed via any other metabolic pathway. Its usual fate is esterification into acylglycerols, chain elongation or desaturation, or esterification to cholesteryl ester. In breast, there is a separate thioesterase specific for acyl residues of C8, C,10, or C12, which are subsequently found in milk lipids.Educational Points:RATE-DETERMINING ENZYMES OF METABOLIC PROCESSESProcessEnzymeDe novo pyrimidine synthesisAspartate transcarbamylase ATCaseDe novo purine synthesisGlutamine-PRPP amidotransferaseGlycolysisPhosphofructokinase-1 PFK-1GluconeogenesisPyruvate carboxylaseTCA cycleIsocitrate dehydrogenaseGlycogen synthesisGlycogen synthaseGlycogenolysisGlycogen phosphorylaseHMP shuntGlucose-6-phosphate dehydrogenase G6PDFatty acid synthesisAcetyl-CoA carboxylase ACCFatty acid oxidationCarnitine acyltransferase 1KetogenesisHMG-CoA synthaseCholesterol synthesisHMG-CoA reductaseHeme synthesisALA synthaseUrea cycleCarbamoyl phosphate synthase 1 