<prompt> 26 year old civil servant, presented with a 1 month history of BL numbness in hands and feet, fatigue and generalized weakness. She had noticed some blurred vision over the previous 2 weeks. She recalled experiencing similar but milder symptoms during the previous summer. Which of the following is most appropriate diagnosis?Multiple sclerosisAlexander diseaseAdrenoleukodystrophyKrabbes disease  <response>: Clinical scenario and imaging points towards diagnosis of Multiple sclerosisMS 1st image shows open ring horse shoe enhancementsuggestive of demyelination and a T2 weighted image showing multiple hyper intense round to oval shaped lesions lying perpendicular to ventricular margin Dawsons finger sign. All the options given are demyelinating disorders. Can be differentiated depending upon different presentations and imaging: Alexander disease: white mater dystrophy of BL frontal lobes. Adrenoleukodystrophy:white mater of BL occipital lobes is involved. Krabbes diseaseGloboid cell leukodystrophy : involvement of BL thalami. 