<prompt> Commonest site of lytic lesion, in multiple myeloma isVeebral columnFemurClaviclePelvis  <response>: Answer is A Veebral column The commonest site of involvement in multiple myeloma is veebral column. Although any bone may be involved, the following order of involvement is most often seen. Veebral column 66 Ribs 44 Skull41 pelvis 28frinur 24 clavicle10 scapula10 