<prompt> Graft rejection is -Cell mediatedHumoralBothNone  <response>: harshmohan textbook of pathology 7th edition. rejection of allograft involves both cell mediated and humoral immunity .cell mediated reaction is mainly responsible for graft rejection and are mediated by T cells.in addition to cell mediated reaction a role for humoral antibodies in ceain rejection reaction has been suggested. These included pre formed circulating antibodies due to pre sensitization of the recipient before transplantation. 