<prompt> Which of the following antifungal drug is developing drug resistance and has not been prescribed for tinea cruris and tinea corporis for the last 2 years?GriseofulvinTerbinafineItraconazoleVoriconazole  <response>: a Griseofulvin,Ref: Katzung, 13th ed., pg. 832 and classkatexPMC4804599 Among various options, topical terbinafine for 4 weeks appears to be the treatment of choice for limited disease tinea corporiscrurispedis. For more extensive disease, the choice is less clear. It is also effective orally. Both terbinafine 250-500 mgday for 2-6 weeks and itraconazole 100--200 mgday for 2-4 weeks appear to be effective. Voriconazole is also an effective drug for these conditions. Griseofulvin is an oral drug used for tinea infections. It is not effective topically. Because of emergence of resistance over the past few years, griseofulvin has been largely replaced by other antifungal agents like terbinafine and itraconazole. Luliconazole is an imidazole topical cream recently approved by the FDA and the CDSCO for treatment of interdigital tinea pedis, tinea cruris, and tinea corporis. 