<prompt> Which of the following disease is associated with the presence of macrophages containing large quantities of undigested and paially digested bacteria in the intestinal mucosa?AmyloidosisWhipples diseaseVibrio cholerae infectionImmunoproliferative small intestinal disease  <response>: Small intestinal lamina propria laden with distended macrophages containing large quantities of undigested and paially digested bacteria is the hallmark feature of whipples disease. The macrophages contain periodic acid schiff PAS positive granules and rod shaped bacilli. In whipples disease, bacteria-laden macrophages can also be found in the mesenteric lymph nodes, synol membranes of affected joints, cardiac valves and the brain. Ref: Robbins Pathologic Basis of Disease, 6th Edition, Pages 814-5 