<prompt> Drug of choice to treat Toxoplasmosis in first-trimester of pregnancy isSpiramycinPyrimethamine-SulphonamideAtovaquoneIvermectin  <response>: Compound Drug class Route Mechanism of action Clinical use Comment Spiramycin Macrolide Oral Blocks proteinsynthesis Toxoplasmosis Used to treat pregnantwomen Ref : Panikers textbook of Medical Parasitology Pgno : 241,242 