<prompt> Advantage of desmopressin over vasopressin in the treatment of diabetes insipidus is that desmopressin:Causes less formation of factor VIIICauses less hypernatremiaIs more selective for V2 receptor subtypeProvides greater relief of excessive thirst the patient is experiencing  <response>: Desmopressin is selective agonist of V2 receptors of vasopressin. V2 receptors are present in kidney and on endothelium whereas V1 receptors are present in blood vessels. Therefore, -Desmopressin is less likely to cause vasoconstriction than vasopressin. -Desmopressin has similar risk of causing hyponatremia due to retention of water. -Desmopressin can release of factor VIII and vWF similar to vasopressin. -Both desmopressin and vasopressin can provide similar relief of excessive thirst. 