<prompt> Which of the following anti neoplastic drug causes hepatotoxicity:6- mercaptopurine5- flurouracilDoxorubicinEtoposide  <response>: Ans. a 6- mercaptopurineRef.: KDT 6th ed. 820 6 mercaptopurine 6-MP is a purine analogue which is metabolized by xanthine oxidase It is a competitive inhibitor of DNA. Allopurinol is NOT given along with 6-MP because allopurinol inhibits xanthine oxidase enzyme, which leads to increased toxicity due to accumulation of xanthine.Anti-Neoplastic DrugsTheir Side EffectCyclophosphamide, ifosphamideHemorrhagic cystitisProcarbazineDisulfiram like reactionBleomycin, busulfanPulmonary fibrosisVincristine, vinblastinePeripheral neuropathyCisplatinOtotoxicity, Nephrotoxicity6Mercaptopurine, 6ThioguanineHepatotoxicityDoxorubicin, DaunorubicinCardiotoxic 