<prompt> Uncoupler in ETCH2SAntimycin a2, 4-dinitrophenolBarbiturates  <response>: Dinitrophenol DNP a potent uncoupler is amphipathic and increase the permeability of the lipoid inner mitochondrial membrane to protons H, thus reducing the electrochemical potential and sho-circuiting the ATP synthase. In this way, oxidation can proceed without phosphorylation.Ref: MN Chatterjea Textbook of Medical Biochemistry, 8th edition, page no: 146 