<prompt> All are true about warfarin, except:It inhibits the activation of vitamin K dependent clotting factorsIts half life is 36 hoursIt can cross placentaIts dose is increased in liver disease  <response>: Warfarin is an oral anticoagulant that acts by inhibiting the γ- carboxylation of glutamate residues in vitamin-K dependent clotting factors II, VII, IX and X.It has 99 binding to albumin that result in.Long half-life t12 36 hours.Small volume of distribution.Lack of urinary excretion of unchanged drug.It readily crosses the placenta. If given during pregnancy, it can result in Contradi syndrome in the fetus.The liver disease reduces the synthesis of clotting factors, thus increases the effect of warfarin. The dose of this drug, therefore, needs to be reduced in liver disease. 