<prompt> What is TRUE about LovastatinInhibits HMG CoA synthetaseInhibits HMG CoA reductaseMyositis may result from its prolonged useDecrease synthesis of cholesterol and causes lenticular opacity  <response>: Ans. is b i.e., Inhibits HMG CoA reductase c i.e., Myositis results from prolonged use d i.e., Decrease synthesis of cholesterol and cause lenticular opacityLovastatin:Mechanism of actionInhibition of HMGCoA reductase Mode of actionDecreased cholesterol synthesis Increased LDL receptors Lipoproteins affectedLDL- DecreasedVLDL- DecreasedTG- DecreasedHDL- IncreasedSite EffectsHepatic dysfunction Severe myositis, CPK Lens opacities ContraindicationsImpaired renal function andIn combination with Gemfibrozil or Nicotinic acid Risk of myositis is increased in these conditions 