<prompt> Beta globin missense gene mutation seen in?ThalassemiaSickle cell anemiaHb BaHbH  <response>: - Point mutation missense in 6th codon of b-globin gene leading to replacement of glutamic acid by valine residue is seen in sickle cell anemia OTHER OPTIONS: - Common mutations of Beta Thalassemia in India: IVS 1-5 G - C IVS 1-1 G - T Codon 4142 Codon 819 619 bp deletion - Hb Ba: Most severe form of alpha thalassemia, results from the loss of all four alpha-globin alleles. - HbH: Dt loss of three of four alpha-globin alleles. 