<prompt> All of the following statements about CreutzfeldtJakob disease are true, EXCEPT :It is a neurodegenerative diseaseIt is caused by infectious proteinsMyoclonus is rarely seenBrain biopsy is specific for diagnosis  <response>: Answer is C Myoclonus is rarely seen: Myoclonus is a very common manifestation of C-.1 disease. Most patient 90 with CJD exhibit myoclonus that appears at various times throughout the illness - Harrisons Creutzfeldt-Jacob disease :Review Nature of illness : Heritable, degenerative, infectious disease. Creutzfeldt- Jacob disease is the most common prion disease infectious in humans Q It is a neurodegenerative disease with major pathological changes confined to CNS Q -Harrisons 16th 2496 The prion concept explains how this disease can manifest both a heritable Q as well as an infectious illness. Q Clinical manifestations : Non specific prodromal symptoms : Fatigue, sleep disturbance, weight loss, headache, malaise, ill defined pain Dementia e deficit in higher coical functions : Memory loss, impaired judgement, decline in intellectual function Myoclonus Q:Most patients 90 exhibit myoclonus at some time throughout illness. Cerebellar signs visual impairment may occur Characteristic ECG finding Q: Paroxysm of high voltage and slow waves Treatment There is no specific treatment. 