<prompt> Which of the following does not occur in lysosomal storage disorders:Increased number and size of lysosomesAccumulation of the polyubiquinated proteinsNo neurological deficitApoptosis defects  <response>: Lysosomal storage disorders : Inborn diseases due to lack or inactivity of lysosomal hydrolases, transpoers or integral membrane proteins. Have severe neurological abnormalities. Large vacuoles and ubiquitinated aggregates, promoting degradation and induction of lysosome biogenesis. Defects in apoptosis. Substrate accumulation in lysosomes increase the size of lysosomes. 