<prompt> A 2 years old child without fever develops bone pain, vomiting and features of increased intracranial pressure following excessive meditation. The drug most likely to be responsible for this is;Vitamin APhenothiazinePhenytoinVitamin D  <response>: Since vit. A is stored in liver, deficiency symptoms appear only after long- term deprivation, but vit A deficiency is quite prevalent, especially among infants and children in developing countries. Manifestations are: Xerosis dryness of eye, Bitot s spots, kerato- malacia softening of cornea, corneal opacities, night blindness nyctalopia progressing to total blindness. Dry and rough skin with papules phryno- derma, hyperkeratinization, atrophy of sweat glands. Keratinization of bronchopulmonary epithe- lium, increased susceptibility to infection. Unhealthy gastrointestinal mucosa, diarrhoea. Increased tendency to urinary stone formation due to shedding of ureteric epithelial lining which acts as a nidus. Sterility due to faulty spermatogenesis,etc ESSENTIALS of medical PHARMACOLOGY SIXTH EDITION-KD TRIPATHI Page:870 