<prompt> site of deposition of a mitochondira seen in organs of all cells except ?brainheakidneymuscles  <response>: DYSTROPHIC CALCIFICATION : Pathogenesis : The final common pathway is the formation of crystalline calcium phosphate Process - two major phases: initiation or nucleation and Propagation Both can occur intracellularly and extracellularly Initiation of intracellular calcification occurs in the mitochondria Initiators of extracellular dystrophic calcification include phospholipids found in membrane-bound vesicles - matrix vesicles Sites of Metastatic calcification May occur in any normal tissue of the body but affects the following organs more commonly: Kidneys, especially at the basement membrane of tubular epithelium and in the tubular lumina causing nephrocalcinosis Lungs, especially in the alveolar walls. Stomach, on the acid-secreting fundal glands. Blood vessels, especially on the internal elastic lamina. Cornea: another site affected by metastatic calcification. Synovium of the joint causing pain and dysfunction. Tubular basement membrane in nephrocalcinosis due to hypercalcaemia REF : robbins 10th ed 