<prompt> Which of the following is a cause of extravascular hemolysis-Falciparum malariaSickle cell diseaseMismatched blood transfusionMicrothrombi in circulation  <response>: Extravascular hemolysis is generally caused by alterations that render the red cells less deformable. Reduced deformability makes the passage difficult leading to red cell sequestration and phagocytosis by macrophages located within splenic cords.This occurs in sickle cell anemia. Intravascular hemolysis caused by intracellular parasites like plasmodium falciparum. Mechanical injury also causes intravascular hemolysis. It can be occured by thrombotic narrowing of microcirculation. Mismatched blood transfusion also causes intravascular hemolysis. Reference : Robbins and Cotran Pathologic basis of disease.South Asia Edition volume 1.page no. 631 