<prompt> Enzyme deficient in tyrosinemia type 1 ?Phenylalanine hydroxylaseTyrosinaseFumarylacetoacetate hydroxylaseTyrosine transaminase  <response>: TyrosinemiaIt is a defect in metabolism of tyrosine. It may be of following types :-Tyrosinemia type-I tyrosinosishepatorenal syndrome :- It is due to defect in fumarylacetoacetate hydroxylase deficiency. Patients with chronic tyrosinosis are prone to develop cirrhosis and hepatic carcinoma. There is cabbage like odor in acute tyrosinosis.Tyrosinemia type - II Richer-Hanha syndrome :- It is due to deficiency of tyrosine transaminase tyrosine aminotrans-ferase.Neonatal tyrosinemia : - It is due to deficiency of hydroxyphenyl pyruvate hydroxylase. 