<prompt> Alport syndrome is characterized by antibodies act against?LamininFibronectinCollagen IVHeparan sulphate  <response>: Ans is c i.e. Collagen IV o Alport syndrome is a type hereditary nephritis characterized by glomerulonephritis, sensorineural hearing loss and eye defects. It is due to defect in a -5 chain of collagen IV COL4 A5.o The most common inheritence is X-linked which causes defect in a -5 chain of collagen IV. Very rare autosomal forms dominant and recessive also exist, which affect a-3 or a-4 chains of collagen 4 COL 4 A3 or COL 4 A4. 