<prompt> What is the effect of progesterone on lipids?Lowers LDL, increases HDLLowers HDL and increases LDLLowers HDL and lowers LDLIncreases LDL and lowers HDL  <response>: Progesterone tend to lower HDL level. The mechanism appears to involve an increase in Hepatic lipaseHL activity. It also decreases triglycerides and modestly lowers LDL levels due to decreased production of VLDL apoB. Ref: Principles and Practice of Endocrinology and Metabolism, 3e. 