<prompt> Pheochromocytoma is associated with -VitiligoCafe-au-lait spotsAsh leaf amelanotic macuslesAcanthosis Nigricans  <response>: Ans. is b i.e., Cafe-au-lait spots o About 25-33 of patients with a pheochromocytoma or paraganglioma have an inherited syndrome. Neurofibromatosis type 1 NF1 was the first described pheochromocytoma-associated syndrome.o The NF1 gene functions as a tumor suppressor by regulating the Ras signaling cascade. Classic features of neurofibromatosis include: Multiple neurofibromas Cafe au lait spots Axillary freckling of the skin Lisch nodules of the iris.o Pheochromocytomas occur in only about 1 of these patients and are located predominantly in the adrenals. 