<prompt> In primary immune deficiency, the following plasma protein fraction can be reducedAlpha1 globulinAlpha2 globulinBeta globulinGamma globulin  <response>: Agammaglobulinemia is a type of primary immunodeficiency of the adaptive immune systemAgammaglobulinemia is characterized by a profound defect in B cell development 1 of the normal B cell blood count. In most patients, very low residual Ig isotypes can be detected in the serum. In 85 of cases, agammaglobulinemia is caused by a mutation in the BTK gene that is located on the X chromosome.Harrison 19e pg: 2107 