<prompt> Which of the following differentiates Hodgkins lymphoma from non Hodgkins lymphoma?Fever, night sweat, weight lossGeneralized lymphadenopathyElderlyReed stern berg cells  <response>: In classic Hodgkin lymphoma, the neoplastic cell is the Reed-Sternberg RS cell. Reed-Sternberg cells comprise only 1-2 of the total tumor cell mass. Most Reed-Sternberg cells are of B-cell origin. The Reed-Sternberg cells consistently express the CD30 Ki-1 and CD15 Leu-M1 antigens. Age-specific incidence rates of Hodgkin lymphoma and non-Hodgkin lymphoma have a bimodal distribution in both sexes, peaking in young adults aged 15-34 y and older individuals 55 y. Asymptomatic lymphadenopathy may be present in both. Constitutional symptoms eg, unexplained weight loss, fever, night sweats are present in 40 of patients. 