<prompt> Finnish of nephrotic syndrome is caused by defect in following protein aEURNephrinPodocinAlpha actininCD2 activated protein  <response>: Nephrin The glomerular capillary wall is a filtering membrane and consists of the following structures i Endothelial cells ii Glomerular basement membrane iii Visceral epithelial cells podocytes iv Mesangial cells The visceral epithelial cell known as podocyte is impoant for the maintenance of glomerular harrier function. They are structurally complex cells that possess interdigitating foot processes pedicels. The adjacent foot processes are separated by 20-30 nm wide filtration slits. The filtration slit or slit diaphragm maintains glomerular barrier function. They present a size selective distal diffusion harrier to the filtration of proteins and it is the cell type that is largely responsible for the synthesis of GBM components. Proteins located in the slit diaphragm control glomerular permeability. Impoant proteins have been identified in this regard Nephrin - Podocin - CD2 associated protein and - Actin cytoskeleton The impoance of these proteins in maintaining glomerular permeability is demonstrated by the observation that mutations in the gene encoding them give rise to nephrotic syndrome sclerosis . The mutations in these genes commonly lead to focal segmental glomerulosilerosis. Gene Chromosome in Prote encoded Disease NPHS1 19q13 Nephrin Congenitial nephritic syndrome of the finnish type NPHS2 lq 25-31 Podocin Steroid resistant nephritic syndrome 30 cases Mutations in the podocyte action-binding protein a actinin 4 also produce FSGS 96. 