<prompt> Most common cause of chronic granulomatous disease in children is -Myeloperoxidase deficiencyDefective phagocytosisDefective H2 O2 productionJobs disease  <response>: Chronic granulomatous disease stas in early life. Chronic suppurative lesions develop in skin and lymph nodes with hepatoslpenomegaly, progressive infiltration of lungs and granulomatous septic ostemyelitis. Diminished H2 02 production affect is the main reason for the bactericidal defect in this disease. Thus leukocyte do not undergo degranulation following phagocytosis. Reference : Anathanarayan panikers 9th edition, pg no:175 p 