<prompt> The treatment of choice for squamous cell anal cancer?Laser fulgarationChemoradiotherapyAbdominoperennial resectionPlatinum-based chemotherapy  <response>: Squamous cell anal cancer is rare but associated with Human papilloma virus infection HPV, Anal intra-epithelial neoplasia AIN and immunosuppression. The current treatment of anal canal carcinoma is chemoradiotherapy combined modality therapy. Chemotherapy include a combination of 5-FU with mitomycin C or Cisplatin. Ref: Bailey and Love Sho Practice of Surgery, 25th Edition, Page 1269; The MD Anderson Manual of Medical Oncology, 2nd Edition, Chapter 22. 