<prompt> Which of the following antihypeensive cause sedationClonidineHydralizineLosaanAmilodipine  <response>: Refer kDT 6e p546 The classic centrally acting antihypeensives such as clonidine, guanfacine and alpha-methyl-DOPA its active metabolite alpha-methyl-noradrenaline induce peripheral sympathoinhibition and a fall in blood pressure as a result of alpha2-adrenoceptor stimulation in the brain stem. These drugs have lost much of their clinical impoance because of their unourable side-effects sedation, dry mouth, impotence, which are also mediated by alpha2-adrenoceptors, although in other anatomical regions 