<prompt> Chromosome involved in Myotonic Dystrophy isChromosome 19Chromosome 20Chromosome 21Chromosome 22  <response>: A Chromosome 19?Myotonic Dystrophy:oGenetics: Myotonic Dystrophy is caused by a triple nucleotide triplet expansion CTG in the non-coding region of the myotonin gene at chromosome 19q13.3.o3 Genetic loci:-DM1: 98 of families 1 Myotonin protein kinase DMPK; chromosome 19q 13.3; Dominant-DM 2: 1 Zinc finger protein 9; Chromosome 3q21; Dominant-DM3: 1 Chromosome 15q21-q24; Dominant.-The condition is characterized by extreme variability, anticipation differential expansion in the maternal paternal germline.-4-37 repeats Normal-50 repeats affected?Inheritance Pattern:oTypical pattern is a heterozygous affected a parent with a homozygous unaffected parent.oEvery child has 1 chance in 2 of having the diseaseoBoth sexes are affected equally.?Myotonic Dystrophy Type 1 DMI:oCommonest form of adult muscular dystrophy incidence 1:6000oAge at onset late teensoInheritance autosomal dominant with anticipation?Myotonic Dystrophy MD is a trinucleotide repeat disease with multi-systemic involvement: muscle myotonia weakness, nerve, CNS MR, heart conduction problems, eyes cataract, Hypersomnolence, Apathy, Cognitive impairments, Endocrine dysfunction etc.,oMyotonia refers to the slowimpaired relaxation of the muscles after voluntary contraction or electrical stimulation.GENETIC DISEASES ASSOCIATED CHROMOSOMES. Chromosome 1: Eliptocytosis, Rh Erythroblastosis, Porphyria cutanea tarda. Chromosome 2: Protein C deficiency. Chromosome 3: Protein S deficiency, Orotic aciduria. Chromosome 4: Huntigntons disease. Chromosome 5: Gardneris syndrome, Familial polyposis coli. Chromosome 6: Haemochromatosis, Congenital adrenal hyperplasia 21-hydroxylase deficiency. Chromosome 7: Cystic fibrosis, Ehlers-Danlos syndrome one form, Osteogenesis imperfecta one form. Chromosome 8: Nil. Chromosome 9: Galactosemia, Nail-patella syndrome. Chromosome 10: MEN type 2. Chromosome 11: Syndrome of Wilms tumor, aniridia, gonadoblas- toma, retardation, Beta-thalassemia, Sickle cell anemia, Acute intermittent porphyria. Chromosome 12: Phenylketonuria, von Willebrands disease.. Chromosome 13: Retinoblastoma, Wilsons disease. Chromosome 14: Nucleoside phosphorylase deficiency, Alpha 1-antitrypsin deficiency. Chromosome 15: Prader-Willi syndrome, Tay-Sachs disease. Chromosome 16: Alpha-Thalaseemia, Gout, LCAT deficiency. Chromosome 17: Growth hormone deficiency type 1A, von Recklinghausen neurofibromatosis. Chromosome 18: Nil. Chromosome 19: Familial hypercholesterolemia, Familial type 3 hyperlipoproteinemia, Myotonic dystrophy; Complement C3 deficiency. Chromosome 20: Adenosine deaminase deficiency. Chromosome 21: Alzheimers disease, Homocystinuria. Chromosome 22: Metachromatic leukodystrophy, Hurler syndrome MPS-I, Scheies syndrome MPS - V 