<prompt> Most common manifestation of clostridium difficile infection is:FeverLeukocytosisAbdominal painDiarrhea  <response>: Most common manifestation of clostridium difficile infection is Diarrhea Stool is soft, watery or mucoid in consistency, with a characteristic odor with 20 bowel movements per day. Other features: Fever in 28 Abdominal pain in 22, Leukocytosis in 50 Unexplained leukocytosis, with 15,000 white blood cells WBCsL may indicate c. difficile infection. Complications: 1. Toxic megacolon and sepsis. Ref: Harrison, Edition-18, page-1092. 