<prompt> The gastrointestinal effects of metoclopramide does not include:It accelerates gastric emptyingIt alters colonic motilityIt reduces reflex from the stomach into the oesophagusIt decreases the bioavailability of digoxin  <response>: Metoclopramide enhances the motility of the gut from the esophagus to the proximal small bowel with little effect on the colonic motility. As the transit time is reduced bioavailability of drugs like digoxin is decreased.It accelerates gastric emptying, relaxes the upper stomach and increases antral contractions thus reducing reflux into the esophagus. 