<prompt> Gigantism is due to:Increased secretion of coisolDecreased secretion of coisolIncreased secretion of growth hormoneDecreased secretion of growth hormone  <response>: - Excess GH results in: overgrowth gigantism during childhood with open epiphysis After fusion of epiphysis - ACROMEGALY - Features of Acromegaly: Coarse facies large tongue Prognathismprotruded lower jaw thick skin broad nose headache visual field defects - Best screening test - IGF 1 levels - TREATMENT: Somatostatin analogues Octreotide GH Receptor antagonist Pegvisomant 