<prompt> Which of the following helps in cell to cell adhesion?InterleukinsInterferonsE-CadherinMatrix metallo proteinase  <response>: Ref: Robbins Pathology, 9th ed. pg. 307 Normal epithelial cells are tightly glued to each other and the ECM by a variety of adhesion molecules. E-cadherin, a cell surface protein, maintains intercellular adhesiveness serving to hold the cells together and relay signals between the cells. In several epithelial tumors, including adenocarcinomas of the colon, stomach, and breast, E-cadherin function is lost. TNF and IL-1 interleukins serve critical roles in leukocyte recruitment by promoting adhesion of leukocytes to endothelium and their migration through vessels. Interferons are inflammatory cytokines. Matrix metalloproteinase MMP regulate tumor invasion by: Remodelling insoluble components of the basement membrane and interstitial matrix By releasing ECM-sequestered growth factors. 