<prompt> 35 year old female patient complains of dry mouth and scratchy feeling in eyes. She is found to have antibodies against anti- SSARo. Which of the following can be the most accurate sole criterion to diagnose the conditionPositive rheumatoid factorLymph node biopsyObjective measurement of lacrimal and salivary gland secretionLip tissue biopsy  <response>: When Sjogrens syndrome is suspected, the most accurate sole criterion for diagnosis of the salivary component of this disorder is labial minor salivary gland biopsy. Antinuclear antibodies, rheumatoid factors, I e_evaied immunoglobulins particularly immunoglobulin G ilgiD, and erythrocyte sedimentation rate, serum amylase or the presence of antibodies directed against the more specific extractable nuclear antigens SS-ARo or SS-131.a are nonspecific markers of autoimmunity, but are important contributors to the definitive diagnosis of Sjogrens syndrome. lig, 60 patients will have antibodies against anti-SSARo. This autoantibody is considered the most specific marker for Sjogrens syndrome although it may be found in a small percentage of patientsj with systemic Iupus crythematosus or other autoimmune connective-tissue disorders.Though there are no universally accepted diagnostic criteria for SS.The strictest criteria include objective measurement of decreased salivary and lacrimal gland function, positive autoimmune serologies and a minor salivary gland biopsy specimen that demonstrates focal mononuclear cell infiltration in a periductal pattern focus score1. 