<prompt> All are true regarding oral hypoglycemic agent, EXCEPT :Effective only after total pancreatectomyMetformin causes lactic acidosisCauses release of insulin from beta-cellsUseful in obese maturity onset diabetics  <response>: Ans. is a Effective only after total pancreatectomy Mechanism of action of sulfonylureasPresence of at least 30 functional pancreas is necessary for the action of oral hypoglycemics Sulfonyl ureas.They act on sulfonylurea receptors present on beta cells of pancreas. This increase insulin secretion.Oral hypoglycemics are used only in uncomplicated type 11 diabetes N1DDM.Both phenformin and metformin cause lactic acidosis Phenformin metformin. 