<prompt> Fifth clinical sign i.e., loss of function functio laesa was added by:Rudolf VirchowElie MetchinkoffLouis PasteurGeorge Bernard  <response>: Acute inflammation Four cardinal signs of inflammation was given by Celsus. Rubor redness Tumor swelling Calor heat Dolor pain. These signs are hallmarks of acute inflammation. A fifth clinical sign, loss of function functio laesa, was added by Rudolf Virchow in the 19th century. Metchinkoff described process of phagocytosis. 