<prompt> Hyperglycemia Associated withMultiple myelomaEwings sarcomaOsteosarcomaChondroblastoma  <response>: The clinical manifestations resulting from the production of metabolic active substance by neoplastic tissue,have been labelled paraneoplastic syndrome.adolescent patients with osteosarcoma Demonstrate abnormal growth hormone ,insulin,growth hormone response to oral glucose loading in78 of the study population No statistical association exists between any of the two or three factors There fore no primary abnormality can be identified high somatomedin levels were noted 72of group study accompanied by Simultaneous elevation of Growth hormone Study adrenal ,gonadal, gonadotropic hormone were essentially normal thrreby ruling these out as endocrine abnormalities Hyperglycemia is also aAssociated with condrosarcoma and fibrosarcoma 