<prompt> According to the latest evidence the latent virus infection which is responsible for the pathogenesis of the achalasia is:Herpes simplex 1Hepatitis C infectionRubellaMeasles  <response>: It is believed that cause of ganglion cell degeneration in achalasia is an autoimmune process attributable to a latent infection with human herpes simplex virus 1 combined with genetic susceptibility. Ref: Harrison, Edition-18, Page-2431. 