<prompt> Leiden mutation is?Non sense mutationMis-sense mutationFrame shift mutationTri nucleotide repeat mutation  <response>: Ans. is b i.e., Mis-sense mutation o Factor V Leiden FVL1 mutation is a mis-sense type of point mutation in the gene for clotting factor V. As a missense substitution of base G to base A, it changes the proteins amino acid from arginine to glutamineo It has autosomal dominant inheritance and is the most common cause of inherited thrombophiliao Factor V is one of the essential clotting factors in the coagulation cascadeo FVL mutation causes activated protein C resistance, hence leading to the hvpercoagulable state.o It is associated with increased risk of DVT recurrent miscarriages 