<prompt> Oral anticoagulants given to pregnant women causeLong bones limb defectCraniofacial malformationCVS malformationCostochondro dysplasia  <response>: Contradis syndrome Skeletal and facial anomalies optic atrophy, microcephaly, chondrodysplasia punctate. Warfarin given in early pregnancy increases bih defects, specially skeletal abnormality foetal warfarin syndrome - hypoplasia of nose, eye socket hand bones, growth retardation. Given later in pregnancy - it can cause CNS defects, foetal haemorrhage, foetal death and accentuates neonatal hypoprothrombinemia Ref: Katzung 12 th ed. 