<prompt> Advantage of cisatracurium over atracurium is?Short duration of actionRapid onsetLess allergicReleases less histamine  <response>: Ans. D Releases less histamineRef: Goodman and Gilman 13the p182Both atracurium and cis-atracurium are non-depolarizing neuromuscular blockers.Both of these are intermediate acting agents both have same duration of action.Both of these agents are cardiostableAtracurium has faster onset of action as compared to cis-atracurium.Both are eliminated by Hoffmans elimination. Atracurium is also metabolized by liver to some extent and result in production of a metabolite laudanosine that can cause CNS toxicity including seizures. On the other hand cis-atracurium is almost completely eliminated by Hoffmans elimination and produce negligible laudanosine.Major advantage of cis-atracurium over atracurium is that the former do not release histamine. 