<prompt> Indomethacin can antagonize the diuretic action of loop diuretics by:Preventing prostaglandin mediated intrarenal-hemodynamic actionsBlocking the action in ascending limb of loop of HenleEnhancing salt and water reabsorption in distal tubulesIncreasing aldosterone secretion  <response>: Loop diuretics release PGs that induce intrarenal hemodynamic changes which secondarily affect salt output. Indomethacin and other NSAIDs inhibit the formation of PG. Therefore, NSAIDs blunt the action of loop diuretics. 