<prompt> DNA analysis of chorionic villusamniocentesis is not likely to detect:Tay-Sachs diseaseHemophilia ASickle cell diseaseDuchenne muscular dystrophy  <response>: Ans. is a, i.e. Tay-Sachs diseaseRef. JB Sharma TB of Obs pg 161; Williams Obs 25e, p 296Ref Operative Obs and Gynae by Randhir Puri, Narendra Malhotra 1e, p 261, 262; Obs. and Gynae Beckmann 5e, p 45In chorionic villous biopsy, trophoblastic tissue is obtained from the chorionic villi, followed by biochemical or molecular DNA analysis or chromosomal analysis of this tissue to diagnose various conditions.Conditions which require molecular or DNA analysisConditions which require biochemical analysis Hemoglobinopathies Sickle cell disease Alpha thalassemia Beta thalassemia Hemophilia A or B Duchenne muscular dystrophy Cystic fibrosis Alpha-1 antitrypsin deficiency Tay Sachs disease Tay Sachs disease Niemann Pick disease Gauchers disease Urea cycle defects Amino acid disorder Congenital adrenal hyperplasia PhenylketonuriaFor diagnosis of Tay Sachs disease biochemical analysis and DNA analysis of chorionic villous sample is done not DNA analysis. For rest all options only DNA analyses would do that is why I am picking that option. 