<prompt> Which is not transmitted familial:Factor V Leiden mutationThalassemiaHemophiliaSickle cell anemia  <response>: Ans. a. Factor V Leiden mutationAutosomal recessive diseases. Often due to defects in structural genes.. Many generations, both males and females are affected.Sickle cell anemia, ThalassemiasX-linked recessive disorders. Sons of heterozygous mothers have a 50 chance of being affected.. No male-to-male transmission.. Skips generations.Hemophilia 