<prompt> A patient suffering from AIDS is on zidovudine, lamivudine and indinavir therapy. He develops pulmonary tuberculosis for which treatment is started. Which of the following should be avoided in him?INHEthambutolPyrazinamideRifampicin  <response>: Ans. D RifampicinRef: KDT 8the p818Rifampicin is a powerful enzyme inducer. It increases the metabolism of protease inhibitors and thus decreases the efficacy of anti-retroviral therapy.Another drug, rifabutin is devoid of these interactions and is the preferred agent for treatment of mycobacterial infections in patients on anti-retroviral therapy. 