<prompt> The vitamin deficiency implicated in metaplasia of respiratory epithelium is:Vitamin-AVitamin-CVitamin-BVitamin-E  <response>: Factors that incriminated in the pathogenesis of lung cancer: Chromosome deletions paicularly 11p, 13q, 17p, and 3p Tumor suppressor gene mutations p53, Hap-1, ErbAb, etc High-level expression of both growth factor genes insulinlike and transferrinlike growth factors Epidermal growth factor receptors HER2neu,EGFR1, etc Protooncogenes c-, N- and L-myc; H-, N-, and K-ras; and c-myb Vitamin A deficiency Air pollution Exposure to arsenic, cadmium, chromium, ether, and formaldehyde Employment as bakers, cooks, construction workers, cosmetologists, leather workers, pitchblende miners, printers, rubber workers, and pottery workers Ref: Theodore P.R., Jablons D. 2010. Chapter 18. Thoracic Wall, Pleura, Mediastinum, Lung. In G.M. Dohey Ed, CURRENT Diagnosis Treatment: Surgery, 13e. 