<prompt> A 20-year-old woman with Hirschsprung disease presents with acute leg pain. The patient had a glioma resected 3 years ago. An X-ray film of the leg reveals a fracture of the left tibia. Laboratory studies show elevated serum levels of calcium and PTH. A CT scan of the patients neck demonstrates a solitary parathyroid mass. Two years later, the patient presents with hypeension, and a CT scan of the abdomen displays a 4-cm mass in the right adrenal. Genetic studies conducted on this patient would likely reveal germline mutations in which of the following protooncogenes?BRCA1RbRETVHL  <response>: - Given clinical features suggests the diagnosis of multiple endocrine neoplasia MEN syndrome aw parathyroid adenoma. - Patients with MEN syndromes types 1 2 have gene mutations that make them susceptible to neoplasia or hyperplasia in multiple organs. MEN-1 WERMER SYNDROME MEN-2A SIPPLE SYNDROME - Mutation of MEN1 - AW Pituitary adenoma Parathyroid adenoma hyperplasia Pancreatic islet cell tumors -Mutation of RET , transmembrane receptor of tyrosine kinase family. -AW Medullary thyroid cancer Pheochromocytoma Parathyroid adenoma hyperplasia - Hirschsprung disease congenital megacolon - Neural crest tumors glioma 