<prompt> Anemia of advanced renal insufficiency is best treated byBlood transfusionsRecombinant human erythropoietinParenteral iron therapyFolic acid  <response>: A normocytic, normochromic anemia attributable to CRD is observed beginning at stage 3 CRD and is almostuniversal at stage 4. The primary cause of anemia in patients with CRD is insufficient production of EPO by the diseased kidney. Management guidelines for correction of anemia of chronic renal disease1.Recombinant human EPO, epoetinalfa.2. Darbepoetinalfa is a hyperglycosylated analog of recombinant human EPO that possesses greater biologicactivity and prolonged half-life.Iron supplementation is usually essential to ensure an adequate response to EPO in patients with CRD because thedemands for iron by the erythroid marrow frequently exceed the amount of iron that is immediately available for erythropoiesis as well as iron stores. 