<prompt> All of the following can cause aplastic anaemia except:Fanconis anaemiaWiskott-Aldrich syndromeDyskeratosis congenitalReticular dysgenesis  <response>: Ans: B Wiskott-Aldrich syndrome Ref: Harrisons 18th ed, pg 887Explanation:Inherited CytopeniasAcquired CytopeniasFanconis anemiaDyskeratosis congenitalShwachman-DiamondsyndromeReticular dysgenesisAmegakaryocytic thrombocytopeniaFamilial aplastic anemiasPreleukemia monosomy 7NonhematologicalDown. Dubowitz. SeckelAplastic anemiaSecondary To :RadiationDrugs and chemicalsViruses: EBV; non A.B.C Hepalitis,Parvovirus B19. HIVlmmune diseases-Eosinophilic fasciitis. hyperimtnunoglobulinemia. thy-momaPNHPregnancyIdiopathicCytopenias: Congenital PRCADiamond- Blackfan syndromeKostmanns syndromeSchwachman-Diamond syndromeReticular dysgenesisAmegakaryocytic thrombocytopeniaThrombocytopenia withabsent radiiCytopeniasPRC ADrugs and toxinsPure white cell aplasiaIdiopathic amegakaryocytic thrombocytopeniaWiskott-Aldrich Syndrome WASX-linked recessive, due to WASP gene mutation; immune dysfunction affecting T lymphocyteRecurrent bacterial infections, eczema, bleedingPredisposes to lymphoma and autoimmune disordersDiagnosed by intracellular immunofluroscence analysis of WAS protein WASPTreatment: Prophylactic antibiotics, IgG supplementation, topical treatment of eczemaSplenectomy for thrombocytopeniaAllogenic HSCT is curative 