<prompt> All are features of adult polycystic kidney disease exceptAutosomal dominant inheritanceDefect in cell- cell interactionBerry aneurysm may be a featureTricuspid valve prolapse  <response>: Ans: d tricuspid valve prolapse It is mitral valve prolapse and not tricuspid valve prolapse that is classically associated with ADPCKDADPCKD:- Inheritance: AD with high penetrance Universally bilateral Mutations - ADPKD1 - Ch. 16ADPCKD2 - Ch. 4 Renal function retained till 4th - 5th decade PKD1 gene encodes Polycystin 1 in tubular epithelium of distal nephron. It is usually involved in the cell-cell and cell- matrix interactions. PKD2 - Polycystin 2 - in all segments of renal tubule. It is a Ca permeable cation channel Progression of the disease is accelerated in blacks with sickle cell trait. Extrarenal manifestations in ADPCKDCysts - Liver- from biliary epitheliumSpleen, pancreas, lungsBerry aneurysm 5 - 10 Colonic diverticulaMitral valve prolapseMost common cause of death- CAD or hypertensive heart disease 40. 