<prompt> Kaposi sarcoma is caused by: March 2013HHV 6HHV 7HHV 8All of the above  <response>: Ans. C i.e. HHV 8 Kaposi sarcoma KS It is a tumor caused by Human herpesvirus 8 HHV8, also known as Kaposi sarcoma-associated herpesvirus KSHV. It was originally described by Moritz Kaposi , a Hungarian dermatologist practicing at the University of Vienna in 1872. It became more widely known as one of the AIDS-defining illnesses in the 1980s. Kaposis sarcoma KS is a systemic disease that can present with cutaneous lesions with or without internal involvement. Four subtypes have been described: - Classic KS, affecting middle aged men of Mediterranean descent; - African endemic KS; KS in iatrogenically immunosuppressed patients; and - AIDS-related KS. Classic KS tends to be indolent, presenting with erythematous or violaceous patches on the lower extremities. African endemic KS and AIDS-related KS tend to be more aggressive. The AIDS-related KS lesions often rapidly progress to plaques and nodules affecting the upper trunk, face, and oral mucosa. The diagnosis can be made with a tissue biopsy and, if clinically indicated, internal imaging should be done. 