<prompt> First change seen in acute inflammation is: September 2009Increased permeabilityVasodilationNeutrophil migrationVasoconstriction  <response>: Ans. D: Vasoconstriction Cardinal signs: Rubor redness due to dilatation of aerioles Calor heat Dolor pain due to pressure on nerve endings by edema fluid and chemical mediator bradykinine Tumor swelling due to edema. Functio laesa loss of function due to inhibition of movement by pain and tissue necrosis. 