<prompt> Antitubercular drug which is least hepatotoxic: September 2010RifampicinPyrazinamideEthambutolINH  <response>: Ans. C: Ethambutol The single biggest problem with TB treatment is drug-induced hepatitis, which has a moality rate of around 5. Three drugs can induce hepatitis: PZA, INH and RMP in decreasing order of frequency. It is not possible to distinguish between these three causes based purely on signs and symptoms. 