<prompt> MOA of acetazolamide used in glaucoma:Increase aqueous productionIncrease uveo-scleral outflowIncrease trabecular outflowDecrease aqueous production  <response>: Ans. d Decrease aqueous productionRef: A.K. Khurana 6th ed. 451-52 ACETAZOLAMIDE is a carbonic anhydrase inhibitor which acts in OAG by decreasing aqueous production. Carbonic anhydrase derivatives are: Acetazolamide, Dorzolamide, Brinzolamide Dorzolamide is mildest carbonic anhydrase inhibitor, hence considered as DOC for glaucoma in children. Alpha-2 agonist Brimonidine, Apraclonidine also act by decreasing aqueous production. Class of drugs which act by increasing outflow: Trabecular outflow: Pilocarpine, Epinephrine Uveoscleral outflow: PG Analogue LatanoprostMust Know TREATMENT OF Glaucoma First line DOC for ACG: Mannitol TOC for ACG: Laser iridotomy DOC for OAG: PG analogue Latanoprost Most powerful anti glaucoma drug: Latano- prost DOC for OAG in India- Timolol Safest anti-glaucoma for children- Dorzolamide 