<prompt> The most common viral cause of Acute liver failure worldwide is:Hepatitis AHepatitis BHepatitis CHepatitis E  <response>: Answer is B Hepatitis B Hepatitis B remains the most common viral agent responsible for Acute Liver Failure Worldwide Fulminant Viral Hepatitis leading to acute liver failure is typically seen with Hepatitis B infection Increased by co-infection or super-infection with Hepatitis D and Hepatitis E infection. The most common hepatitis virus responsible for fulminant disease and acute liver failure varies from one geographic region to the other. Hepatitis B is the most common cause of Acute Liver Failure in USA, Europe and Japan and accounts fbr a significant percentage of cases in the rest of the world thereby being the single most impoant virus implicated in Acute Liver Failure Liver failure occurs in approximately 1 percent of patients with Acute Hepatitis B. Note: Hepatitis E is the most common cause of Acute Liver Failure in India In India, over 95 of acute liver failure is due to viruses, with 40 secondary to hepatitis E and 25-30 to hepatitis B. Hepatitis E is the most common cause of Acute Liver Failure in India - Sherlocks Diseases of the Liver and Biliary System 