<prompt> A 44 year old man complaints of abdominal distention and nausea since few months. USG of abdomen shows a growth on right lobe of the liver. Tumor marker study shows the evidence of primary hepatocellular carcinoma. All of the following tumor markers will be raised in this patient, EXCEPT:Alpha fetoproteinAlpha 2 macroglobulinPIVKA-2DCP  <response>: AFP is a serum tumor marker for HCC; however, it is only increased in approximately one-half of patients. The lens culinaris agglutinin-reactive fraction of AFP AFP-L3 assay is thought to be more specific. The other widely used assay is that for des-gamma-carboxy prothrombin DCP, a protein induced by vitamin K absence PIVKA-2. Many other assays have been developed, such as glypican-3, but none have greater aggregate sensitivity and specificity. Ref: Carr B.I. 2012. Chapter 92. Tumors of the Liver and Biliary Tree. In D.L. Longo, A.S. Fauci, D.L. Kasper, S.L. Hauser, J.L. Jameson, J. Loscalzo Eds,Harrisons Principles of Internal Medicine, 18e. 