<prompt> Which of the following is the most likely reason why fentanyl does not disturb cardiovascular stability as much as morphine?is water solubleis lipid solubledoes not stimulate histamine releaseis long acting  <response>: Morphine releases histamine and can cause cardiovascular instability. Fentanyl does not release histamine, and causes only mild decreases in heart rate and blood pressure. Fentanyl, a lipid-soluble drug, has an elimination half-life between 3 and 4 hours. It is 100 times more potent than morphine. 