<prompt> Best site for taking biopsy for viral esophagitis isEdge of ulcerBase of ulcerAdjacent induratrd area around ulcerSurrounding normal mucosa  <response>: Refer Robbins page no 768 Herpes virus typically cause punched out ulcers the nuclear inclusions of herpes virus arr found in a narrow rim of degenerating epithelial cells at the margin of ulcer For biopsy should be taken from edge of ulcer in HSV and base of ulcer in CMV 