<prompt> Wilsons disease is diagnosed by:Increased serum ceruloplasminDecreased liver copperIncreased urinary copper excretionDecreased urine copper excretion  <response>: ANSWER: C Increased urinary copper excretionREF: Harrisons Internal Medicine 17th ed Chapter 354. Wilson Disease Repeat from June 2010Tests for Wilson DiseaseTestUsefulnessNormal ValueIn Heterozygous CarriersIn Wilson DiseaseSerumceruloplasmin-180-350 gLLow in 20Low in 90KF ringsAbsentAbsentPresent in 99 if neurologic or psychiatric symptoms present.Present in 30-50 in hepatic presentation and presymptomatic state24-h urine Cu-r0.3-O.8 mol 20-50 gNormal to 1.3 mol 80 g1.6 mol 100 g in symptomatic patients 0.9 to 1.6 mol 60 to 100 g in presymptomatic patientsLiver Cu0.3-0.8 molg 20-50 g tissueNormal to 2.0 mol 125 g3.1 mol 200 g obstructive lnrer disease can cause false-positive resultsHaplotypeanalysis-Siblingsonly0 Matches1 Match2 Matches 