<prompt> A 15-year-old male presents with hematuria. he has previous diagnoses of deafness and corneal dystrophy. Urinalysis shows 1 proteins, no ketones, no glucose, 1 blood, and no leukocytes. A renal biopsy reveals tubular epithelial foam cells by light microscopy. By electron microscopy, the glomerular basement membrane shows areas of attenuation, with splitting and lamination of lamina dense in other thickened areas. The most probable diagnosis is-Acute tubular necrosisBerger diseaseMembranous glomerulonephritisAlpo syndrome  <response>: Alpo syndrome: Electron Microscopy is diagnostic and shows basket weave appearance of the GBM. Alpo syndrome: Hereditary nephritis Abnormal a3 COL4A3, a4 COL4A4, or a5 COL4A5 chain of type IV collagen Hematuria with progression to chronic renal failure Nerve deafness Eye disorders Foamy cells in the interstitium. Ref: RAM DAS NAYAK EXAM PREPARATORY MANUAL FOR UNDERGRADUATES 2nd ed. pg no: 612 