<prompt> A patient on lithium therapy developed hypertension. After being started on thiazides for hypertension, he suffered from coarse tremors and other symptoms suggestive of lithium toxicity. Explain the likely mechanism of this interaction.Thiazide inhibits metabolism of lithiumThiazides increases tubular reabsorption of lithiumThiazides acts as add on drug for lithiumThiazides and lithium both cause tremors  <response>: Majority of sodium reabsorption occurs in proximal convoluted tubule Both sodium Na and Lithium Li carry one electron in their outer shell, which depicts Both can easily obtain a stable configuration of inert gas by losing one electron from their outer shell Both lose their outer shell electrons in reactions to form positive ions with a 1 charge Both have similar physical and chemical properties DiureticsCauses hyponatremiaCompensatory increase in sodium reabsorption from tubulesLithium also gets reabsorbed similarity with sodiumPlasma levels of lithium riseLithium toxicity symptoms occurs 