<prompt> Which of the following cephalosporins does not need dose modifications even in presence of decreased GFR-CefipineCefoperazoneCefotaximCefuroxine  <response>: Ans. is b i.e., Cefoperazone o Cefoperazone is primarily exreted in bile in contrast to other cephalosporins that are usually excreted by the kidney -- safe in renal failure. o Cephalosporins that can be used in presence of renal failure :- i Cefoperozone, ii Ceftriaxone, iii Cefoperamide 