<prompt> Amyotrophic lateral sclerosis involves:Upper motor neuron and lower motor neuron bothPosterior column onlyLower motor neuron onlyRaphae nucleus  <response>: A i.e. Upper motor neuron and lower motor neuron both.Amyotrophic lateral sclerosis is the most common form of progeressive motor neuron disease. It involves both upper motor neuron UMN lower motor neuron LMNQ.Motor neuron disease Is characterized by degeneration of motor neurons, either upper motor neuron or lower motor neuron or both. 