<prompt> Antidote of paracetamol poisoningFlumazenilN-acetyl cysteineNalexoneSodium bicarbonate  <response>: i.e. N- acetyl cysteine: 680 - Ghai 7thOverdosage of PCM is treated with N-acetyl cysteine used orally within 16 hour after ingestion at a loading dose of 140 mg Kg diluted to 5 solution orally. Followed by 70 mg Kg q 4hr for another 2 daysPCM is the most common analgesic, antipyretic used in childrenParacetamol produces a hghly reactive toxic minor metabolites - N-acetyl benzoquinone amine. Normally this metabolite is detoxified by conjugation with glutathione - when a very large doses of paracetamol is taken glucuronidation capacity is saturated and this metabolite is not detoxified Hepatic glutathione is depletedExcess metabolite N acetyl benzoquinone binds to protein in liver cells and renal tubulesCentrilobular hepatic necrosisThis single most important laboratory test in patient who present after acetaminophen is the acetaminophen level in the serum.Antidotes for common poisoningPoison Antidote Acetaminophen PCMN- acetyl cysteine AnticholinergicsPhysostigmine BenzodiazepinesFlumazenil DigoxinDigoxin immune antibody MethemoglobinemiaFragnent OpioidsMethylene blue OrganophosphatesNaloxone SalicylatesAtropine Ethylene glycolSodium bicarbonates MethanolFomepizole 