<prompt> A patient with abetalipoproteinemia frequently manifests with delated blood clotting. This is due to inability toProduce VLDLSynthesize fatty acidsProduce chylomicronsSynthesize clotting factors  <response>: Type-III: Familial Dys-Beta Lipoproteinaemia:Synonyms: Broad Beta disease, Remnant removal diseaseThe disease is characterised by:Increase in b-lipoproteins LDL Increase in Pre-b-lipoproteins VLDL ;Actually rise is in IDL VLDL remnant. This appears as broad b-band floating b-band-b- VLDL on electrophoresis. Also, there is hypercholesterolemia and hyperiglyceridemia.Inheritance: Autosomal dominant.Metabolic defects:Increased concentration of apo-E .Increased synthesis of apo-B .Conversion of normal VLDL to b-VLDL IDL and its degradation without conversion to LDL. Defect is in Remnant metabolism.Clinical feature: Presents with Xanthomastuberous and palmar Xanthomas. Premature cardiovascular diseases and atherosclerosis common. Also prone to develop peripheral vascular diseases.Treatment:By weight reductionLow carbohydrate diets, containing unsaturated fats and little cholesterolRef: Textbook of Medical Biochemistry, 8th Edition, Dr Brig MN Chatterjea, Rana Shinde, page no: 452,453 