<prompt> Aggrevation of symptoms of angina in a patient when given nitrates is seen inAoic regurgitationMitral regurgitationSingle left coronary aery stenosisIdiopathic hyperophic subaoic stenosis  <response>: Ref Harrison 19 th ed pg 1568 Idiopathic hyperophic cardiomyopathy HOCM is a dynamic outflow obstruction which is increased by any mechanism decreasing the preload . Nitrates decrease the preload,the volume of blood in LV and thereby increase the dynamic obstruction and symptom of angina 