<prompt> Mechanism of action of paxclitaxel isTopisomaerse inhibitionIncrease the polymerization of tubulinInhibits protein synthesisAlkylation of DNA  <response>: Refer Katzung 10th893 Refer KDT 6e p825 Taxanes act by increasing the polymerization of beta tubulin whereas vinca alkaloid cause inhibition of tubulin polymerization. Both of these drugs act by causing the disruption of mitosis and are active in M phase of cell cycle 