<prompt> In Huntingtons chorea all of the following can be found exceptSlurred speechProgressive dementiaDysmetriaDegeneration of striatal GABA-ergic neurons  <response>: C Dysmetria Huntingtons Disease is a fatal autosomal dominant disorder characterized by progressive motor, emotional and cognitive dysfunction. Onset is typically between the ages of 35 and 45 years. It is caused by mutations in the Huntingtons gene on the short arm of chromosome. Pathophysiology of Huntingtons disease Loss of the intrastriatal GABA-ergic and cholinergic neurons, ii. The loss of the GABA-ergic pathway to the external-- Pallidum releases inhibition, permitting the hyperkinetic features of the disease to develop, iii. Degeneration of the nigrostriatal dopaminergic system causes Parkinsons disease see below. Clinical features of Huntingtons disease: Hyperkinetic choreiform movement, ii. Speech is slurred, iii. Progressive dementia. Neurotransmitter involved in nigrostriatal pathway is Dopamine. Dysmetria is a condition in which disturbance of the power to control the range of movement in muscular action. 