<prompt> Malignancy is typically associated with disordered differentiation and mutation .which of the following mentioned options best describes anaplasiaHepatic tumor cells synthesizing bileSkin tumor cells producing keratin pearlsBronchial epithelial cells producing keratin pearlsMuscle tumor cells forming giant cells  <response>: Neoplastic cells may be. Similar to normal cells found in the tissue of origin, which defines the malignancy as well differentiated or low grade. Alternatively the neoplastic cells may lack most of the characteristics of normal cells found in the tissue of origin ,which defines the malignancy as poorly differentiated or high grade . Tumor that contain neoplastic cells in the midst of this spectrum are termed moderately differentiated or medium grade.anaplastic means complete lack of differentiation 