<prompt> Anti-ds DNA antibodies are most specific forSLERheumatoid ahritisSclerodermaPolymyositis  <response>: The best screening test for SLE is a demonstration of Antinuclear antibodies ANA Sensitive test for SLE ANA Specific test for SLE Anti-ds DNA and Anti Sm antibody Ref - Harrisons internal medicine 20e pg 2515, 2516f, 2517t, 2518t, 2522 