<prompt> AGE-RAGE signaling axis is related toAgeingOncogenesisDiabetesAlzheimer disease  <response>: AGE-RAGE signalling axis is related to chronic complications in diabetes.Advanced glycation end products AGEs are formed as a result of nonenzymatic reactions between intracellular glucose-derived dicarbonyl precursors glyoxal, methylglyoxal, and 3-deoxyglucosone with the amino groups of both intracellular and extracellular proteins. The natural rate of AGE formation is greatly accelerated in the presence of hyperglycemia. AGEs bind to a specific receptor RAGE that is expressed on inflammatory cells macrophages and T cells, endothelium, and vascular smooth muscle.Robbins pathology 9e pg: 1115 