<prompt> Which of the following is not TRUE about bone metastasis?Skeletal metastases are typically unifocalHigher serum level of alkaline phosphataseMost common primary in female is breastProstate produce osteosclerotic lesion  <response>: Skeletal metastases are typically multifocal, not unifocal Metastases are usually osteosclerotic and pathologic fractures are common. Osteoblastic lesions are rare and typically seen in carcinoma prostate. Osteoblastic lesion are associated with higher level of alkaline phosphatase and if extensive my produce hypoglycemia. The commonest source of bony metastases, is carcinoma of the breast; next in frequency are carcinoma of prostate in males, kidney, lung, thyroid bladder and gastrointestinal tract Ref: Apleys Ohopedics 8e, Page 193; Robbins 7e, Page 1303. 