<prompt> Alteplase differs from streptokinase as itIs longer actingIs derived from human kidneyIs cheapActivates plasminogen bound to fibrin  <response>: Refer KDT 6e p606 Fibrinolytics are the drugs which activate plasminogen to form plasmin and thus helps in lysis of thrombus These drugs can cause bleeding as the major adverse effect due to lysis of physiological thrombi as well as due to excessive amount of plasma generated in the circulation 