<prompt> A cervical Pap smear repo stating that koilocytic atypia is present indicates the:-Presence of high-grade cervical intraepithelial neoplasiaCytologic effect of herpesvirus type 2Cytologic effect of human papillomavirusPresence of chlamydial infection  <response>: HPV infection of squamous cells Produces wrinkled nuclei surrounded by a clear halo. This is called koilocytosis. Whether it is indicative of a low or a high grade lesion in the cervix requires tissue documentation. This is usually obtained with a colposcopic biopsy. 