<prompt> Inclusion body of CMV is -Cowdry type ACowdry type BIntranuclearCytoplasmic  <response>: Ans. is c i.e., Intranuclear Cytomegalovirus CMV Also known as salivary gland virus CMV is the largest virus amongst herpes viruses They are characterized by enlargment of infected cells cytomegalic cells and intranuclear inclusions. Intranuclear inclusion is eccentrically placed and is surrounded by a halo - owls eye appearance. Once infected an individual carries CMV for life CMV is the most common organism causing intrauterine infection. CMV is the most common pathogen complicating organ transplantation.Clinical manifestations Most of the infections in immunocompetent persons are asymptomatic. Clinical features are divided intoA Congenital infection Infection is acquired in pregnancy. It causes cytomegalic inclusion disease. Most common presentation is petechiae, hepatosplenomegaly and jaundice. Other features are microcephaly, cerebral calcification, chorioretinitis, IUGR, prematurity and thrombocytopenia.B Perinatal infection Infection is acquired during delivery or postnatally by breast feeding. Most patients are asymptomatic.C Beyond neonatal period Most common presentation is heterophile antibody-negative mononucleosis CMV mononucleosis.D Immunocompromized host It causes retinitis, colitis, gastritis, esophagitis, pneumonitis, fever, leukopenia and hepatitis. Maximum risk of infection after kidney transplant is between 1-4 months after transplantation. Most common presentation is fever, leukopenia and hepatosplenomegaly. Most common presentation after bone marrow transplantation is interstitial pneumonia.Laboratory diagnosis Definitive diagnostic test most specific test is isolation of virus from urine, saliva, blood or bronchoalveolar washing. Most sensitive test is PCRfor viral genome DNA detection in blood or intraocular fluid in CMV retinitis. Serology IgM or IgG is not very useful.Treatment Ganciclovir or valganciclovir are drugs of choice. Foscarnet is used for CMV retinitis. 