<prompt> Low apparent volume of distribution aVd indicates:Drug is not extensively distributed in organs and tissuesLow bioavailabilityLow T 12Very low efficacy  <response>: Ans. A. Drug is not extensively distributed in organs and tissuesVolume of distribution Vd is defined as ratio of the amount of drug in the body and the plasma concentration of drug CpVd Total dose administered to patientCp Volume of distribution can be determined by various factors:A. More plasma protein binding restricts drug to plasma, hence there will be less distribution to extravascular space and tissues least Vd .B. Polar compounds have slightly more volume of distribution Vd :0.2LkgC. More tissue binding capacity or more lipid solubility will make drug to cross most of the membranes, including blood-brain barrier making volume of distribution more.D. Sequestration of drugs in the particular tissue makes its volume of distribution even more than whole blood volume e.g., Chloroquine has large volume of distribution as it gets sequestered in the liverWater 0.6 LkgLipid soluble molecules: e.g., EthanolExtracellular water 0.2LkgWater-soluble molecules: e.g., Gentamicin Polar compoundsBlood 0.08LkgPlasma 0.04LkgStrongly plasma protein-bound molecules and very large molecules: e.g., heparin 