<prompt> A 28 year old women suffering form sickle cell anaemia marries a 31 year old with no abnormality. What are the respective probabilities to have i sickle cell disease and ii sickle cell trait in their offspring?0 and 10025 and 5050 and 2525 and 25  <response>: Robbins basic pathology 9th edition page no 411,412 Answer is option 1, 0and100. Since mother is suffering from sickle cell anemia her gamete contains sickle cell trait, but as the fathers gamete is fre of sickle cell trait there is no chance of offspring suffering from the disease but there is 100 of chance of offspring being sickle cell trait. 