<prompt> Lebers optic neuropathy-Typically presents in the fourth decade of lifeMales do not transmit the diseaseIs inherited in autosomal X-link fashionThe optic disc is pale early in the disease  <response>: Lebers hereditary optic neuropathy is a mitochondrial disorder. Since mitochondrial DNA is exclusively derived from mothers, males do not transmit the disease.The optic disc becomes pale and atrophic in late atrophic phase not early. 