<prompt> Delayed clotting in abetalipoproteinemia is due to:A Decreased VLDLReduced clotting factor synthesisDecreased chylomicronsDecreased fatty acid synthesis  <response>: Ref: Harrisons Principles of Internal Medicine 18th edition, pg 3153Explanation:Lipoproteins-Transport hydrophobic lipids thro plasma fluids to from tissuesAbsorption of dietary cholesterol, fatty-acids fat soluble vitamins A. D, E, KTransport of cholesterol, triglycerides fat- soluble vitamins from liver to per tissuesTransport of cholesterol from peripheral tissues to liverAbetalipoproteinemiaIt is an autosomal recessive disorder.M utation i n the microsomal triglyceride transfer protein MTTP gene needed for transport of lipids and chplesterol fat-soluble vitamins.Low VLDL, chylomicronsFat malabsorption-Vitamin K deficiency- coagulopathySevere vit E deficiency-neurological manifestations A can thocytoisisHypocholesterolemiaRetinitis pigmentosa, posterior column neuropathy myopathyTreated with high dose of Vitamin E other vitamins.Vitamin K dependent clotting factore are-II prothrombin, VII, IX XVit K is needed for post-translational modification of glutamate residues to a-carboxyglutamate, needed for activity of the above factors.Vit K is a fat-soluble vitamin, it is a co-factor for post-translational modification of glutamate residues to y-carboxyglutamate on the clotting factors II. VIE IX X. Warfarin blocks the reductase competitively inhibits the effects of vitamin K. 