<prompt> Defect leading to thalassemia lies inHaemoglobinOsmotic fragilityRBC membranePlatelets  <response>: Disorders off hemoglobinDisorders of hemoglobin may be of two types -1 Qualitative defect of hemoglobin hemoglobinopathyHem oglobinopathies are disorders of hemoglobin, characterized by a defect that results in abnormal structure of one of the globin chain of hemoglobin.Examples are - Siclde cell anemia, HbC, HbE, HbD-Punjab, Hb O-Arab, Hb Lepore.2 Quantitative defect of hemoglobinThese disorders are characterized by a defect that results in decreased rate of synthesis of one of the globin chain of hemoglobin.Example - Thalassemia 