<prompt> Which of the following statement is false: March 2007Granulomatous inflammation is found in Crohns disease.Perianal lesions are common in Crohns diseaseStricture involving the colon is found in ulcerative colitisFistula formation is common in Crohns disease.  <response>: Ans. C: Stricture involving the colon is found in ulcerative colitisCrohns diseaseregional enteritis is an autoimmune disease, which can affect any pa of the gastrointestinal tract from mouth to anus terminal ileum is the area most commonly affected.Anal lesions are also commonThe disease is characterized by areas of inflammation with areas of normal lining between in a symptom known as skip lesions.Microscopy of Crohns disease show focal areas of chronic inflammation involving all layers of the intestinal walls.There are non-caseating granulomas, but these are found in only 60 of patients.The main gastrointestinal symptoms are:Abdominal pain may be the initial symptom of Crohns disease. It is often accompanied by diarrhea, especially in those who have had surgery. The diarrhea may or may not be bloody.The nature of the diarrhea in Crohns disease depends on the pa of the small intestine or colon that is involved. Ileitis typically results in large-volume watery feces. Colitis may result in a smaller volume of feces of higher frequency.Visible bleeding in the feces is less common in Crohns disease than in ulcerative colitis, but may be seen in the setting of Crohns colitis.Although the association is greater in the context of ulcerative colitis, Crohns disease may also be associated with primary sclerosing cholangitisPerianal discomfo may also be prominent in Crohns disease. Itchiness or pain around the anus may be suggestive of inflammation, fistulization or abscess around the anal area or anal fissure.Crohns disease is associated with a type of rheumatologic disease known as seronegative spondyloahropathy. This group of diseases is characterized by inflammation of one or more joints ahritis or muscle inseions enthesitis. Common complications of inflammation include scarring that can produce intestinal blockage obstruction and deep ulcers penetrating through the bowel wall that can create pus-filled pockets of infection abscesses or abnormal connecting channels between the intestine and other organs fistulas.When the large intestine is affected extensively by Crohns disease, rectal bleeding commonly occurs.After many years, the risk of colon cancer cancer of the large intestine is greatly increased.About one third of people who develop Crohns disease have problems around the anus, especially fistulas and cracks fissures in the lining of the mucus membrane of the anus.Crohns disease may lead to complications in other pas of the body. These complications include gallstones, inadequate absorption of nutrients, urinary tract infections, kidney stones, and deposits of the protein amyloid in several organs amyloidosis.A colonoscopy is the best test for making the diagnosis of Crohns disease as it allows direct visualization of the colon and the terminal ileum, identifying the pattern of disease involvement. Finding a patchy distribution of disease, with involvement of the colon or ileum but not the rectum, is suggestive of Crohns disease, as are other endoscopic stigmata. The most common disease that mimics the symptoms of Crohns disease is ulcerative colitis, as both are inflammatory bowel diseases that can affect the colon with similar symptoms.It is impoant to differentiate these diseases, since the course of the diseases and treatments may be different. 