<prompt> Kalli, 35yrs old female presents with Bilateral deep vein thrombosis in legs. There is past history of recurrent foetal loss and one attack of pulmonary embolism. Screening tests of coagulation reveal a prolonged aPTT. Likely diagnosis is:Factor VIII deficiencyInherited Protein C and S deficiencyAnti phospholipid syndromeHereditary excess of Anti thrombin III  <response>: A female with history of deep vein thrombosis in legs, recurrent foetal loss and one attack of pulmonary embolism with prolonged aPTT highlights the diagnosis of a hypercoagulable state which is anti phospholipid syndrome. Ref: Hughes Syndrome: Antiphospholipid Syndrome By Munther A. Khamashta, 2006 ; Textbook of Obstetrics By Dutta, 6th Edition, Page 343 ; Williams Obstetrics, 21st Edition, Page 1390 