<prompt> Endothelium-Derived Relaxing Factor EDRF induced vasodilatation is mediated byIncreased intracellular CGMPDecreased intracellular CGMPIncreased extracellular cyclic AmpDecreased intracellular cyclic Amp  <response>: Endothelium-derived relaxing factor EDRF is produced and released by the endothelium to promote smooth muscle relaxation. The best-characterized is nitric oxide NO. Some sources equate EDRF and nitric oxide. Although there is strong evidence that nitric oxide elicits vasodilation, there is some evidence tying this effect to neuronal rather than endothelial reactions.Ref: Ganong;s review of medical physiology; 24th edition; page no: 116 