<prompt> The most clinically significant skin eruption associated with M. pneumoniae infection is:Erythema multiforme majorBullous eruptionsToxic epidermal necrosisPyostomatitis vegetans  <response>: Erythema multiforme major Stevens-Johnson syndrome is the most clinically significant skin eruption associated with M. pneumoniae infection. Ref:Harrisons Principles of Internal Medicine, 18th Edition, Page 1418 