<prompt> In treatment of parkinsonism, levodopa is combined with carbidopa:Decrease the treatment durationDecrease the central side effects of L-dopaDecrease the effectiveness of L -DopaIncrease the crossing of levodopa through blood brain barrier  <response>: Ans. D. Increase the crossing of levodopa through blood brain barrierLevodopa is drug given for parkinsonism. It is metabolized by Dopa decarboxylase enzyme which is present peripherally. So when given alone it get metabolized and do not cross the blood brain barrier. Carbidopa on other hand is Dopa decarboxylase inhibitor which protect levodopa and allows its entry into the brain. 