<prompt> Which is activated for nuclear fragmentation in apoptosis -CaspasesApaf - 1Oxygen free radicalsAll  <response>: Caspases and endonuclease cause chromatin fragmentation in apoptosis. They are inactive, so first they should be activated. Cytochrome ;c; binds with Apaf-1 and this complex activates caspases. Caspases cause fragmentation of chromatin and also activate endonuclease. About option ;b; Though Apaf-1 helps in activation of caspases, it has no role in chromatin framentation and It does not have two seprate forms active or inactive. It just forms complex with cytochrome ;C; to activate caspases. REF: ROBBINS pathology 10th edition 