<prompt> Most common presentation of neuroblastoma isLytic lesion in skull with suture diasthesisLung metastasisRenal invasionSecondaries in brain  <response>: Most frequent site of metastasis from neuroblastoma is bone : where metastasis occurs very early.Lytic lesions in skull and sutural diastasis are manifestations of bony metastasis to skull, and hence the earliest feature, amongst the options in the questions. 