<prompt> Amiloride can cause hyperkalemia due to its action on:Potassium channelSodium channelNa Cl- symporterHKATP ase  <response>: Ans. B. Sodium channelAmiloride and triamterene are K sparing diuretic, they act by inhibiting epithelial Na channel. When they inhibit the sodium channel, there is no generation of electrical gradient and thus potassium and hydrogen are not excreted. They may be responsible for hyperkalemia. 