<prompt> Schistocytes are seen in: March 2012, March 2013Iron deficiency anemiaMegaloblastic anemiaHaemolytic anemiaAplastic anemia  <response>: Ans: C i.e. Haemolytic anemiaAnemias and featuresPeripheral smears of iron deficiency anemia shows smaller RBC microcytic and paler RBC hypochromic. Poikilocytosis in the form of small, elongated RBCs pencil cells is also characteristically seenThe presence of RBC that are macrocytic and oval macro-ovalocytes is highly characteristic of megaloblastic anemia. Neutrophils are also larger than normal macropolymorphonuclear and hypersegmented, having five or more nuclear lobules instead of the normal three to fourThe most significant hemolysis caused by trauma to RBC is seen in individuals with cardiac valve prostheses and micro-angiopathic haemolytic anemia DIC, TTP, HUS, SLE and malignant hypeension. Traumatic damage to RBC leads to the appearance of red cell fragments schistocytes, burr cells, helmet cells, and triangle cells in blood smears.Aplastic anemia is best appreciated in marrow biopsies. The markedly hypocellular bone marrow is largely devoid of hematopoietic cells; often only fat cells, fibrous stroma, and scattered lymphocytes and plasma cell remains. Marrow aspirates often yield little material a dry tap. 