<prompt> Which of the following medications is contraindicated in patients with allergy to sulphonamides?LevobunololBimatoprostBrinzolamideBrimonidine  <response>: Acetazolamide, Dorzolamide and Brinzolamide are sulfonamide derivatives which act by inhibiting carbonic anhydrase carbonic anhydrase inhibitor. Being sulphonamide derivatives they are contraindicated in patients with allergy to sulphonamides. Ref: Essentials of Pharmacology By K D Tripathi, 5th Edition, Pages 188, 553; Medicinal Chemistry By Sriram, Page 227. 