<prompt> True about anticonvulsants: PGI Nov 2009Carbamazepine safe in pregnancyLamotrigine is safeMonotherapy is recommendedNewer drugs are safe  <response>: Ans: C Monotherapy is recommended Phenytoin, Carbamazepine. Valproate and Phenoharhital all have been associated with teratogenic effectsVery recent reports suggest a higher than expected incidence of cleft lip with the use of lamotrigine- during pregnancy.Preganant women shoul be maintained on effective drug therapy preferably on monotherapy at the lowest effective dose, especially during the first trimester.Patients should also take folateQ 1-4 mgd to prevent neural tube defects.The risk of teratogenicity increases with the number of medications9 used e.g. 10 risk of malformations with three drugs.Vit. K is given during last month of pregnancy: to prevent coagulopathy intracerebral haemorrhage in newborn common with antiseizure drugs that induce CYPs 