<prompt> All of the following is true about lebers hereditary optic neuropathy exceptMale predominanceX-linked recessive traitProfound vision lossCardiac preexcitation syndrome  <response>: X-linked recessive trait Leber hereditary optic neuropathy is transmitted in a pattern of maternal inheritance. The defect is in the Mitochondrial DNA Lebers hereditary optic neuropathy Remember: Mitochondrial DNA inheritance Male predominance Visual loss profound permanent Rarely spontaneous recovery may occur Characteristic fundus picture: Triad of - Microangiopathic telangiectasias - Pseudoedema of disc - Vascular touosity Onset is sudden, mono ocular, painless vision loss. 