<prompt> A 10 yr old boy with mass in the abdomen. On imaging the paraaortic LN is enlarged. On biopsy starry sky appearance is seen. What is the underlying abnormality?p53 gene mutationRB gene mutationTranslocation involving BCR-ABL genesTranslocation involving MYC gene  <response>: Ans. d Translocation involving MYC geneRef: Robbins 9thpg 597; 8th607Macrophages with abundant clear cytoplasm showing: characteristic starry sky pattern are seen in Burkitt lymphoma 