<prompt> C-ANCA is positive in?Wegners granulomatosis WGTakayasu arteritis TAPolyarteritis nodosa Classic PANGiant cell arteritis GCA  <response>: Ans is a i.e; Wegners granulomatosis WG Antineutrophilic cytoplasmic antibody ANCAo ANCA are heterogenous group of autoantibodies directed against antigens which are found within the primary granules of neutrophil and in the lysosomes of monocytes and in ECs. The description of these autoantibodies is based on the immunofluorescence pattern of staining of ethanol fixed neutrophils.With immunofluorescence two principal patterns are recognized1 Cytoplasmic ANCA c-ANCAo It is targeted against proteinase-3. It is found in Wegners granulomatosis.2 Perinuclar ANCA p-ANCAo It is targeted against myeloperoxidase. It is found in microscopic polyangitis, chrug-strauss syndrome, idiopathic crescentic glomerulonephritis, Good-pasture syndrome, and renal limited vasculitis 