<prompt> Bioavailability of Ramelteon is?271030  <response>: Reference: Goodman Gilmans The Pharmacological Basis of Therapeutics, 12th ed., Pg. 1972.Ramelteon is rapidly absorbed orally, undergoes extensive first pass metabolism in liver, so that bioavailability is low F 1.8 and elimination t12 is 13 hours. 