<prompt> TNF is secreted by activated:MacrophagesNeutrophilsLymphocytesEosinophils  <response>: Ans: a Macrophages Ref: Robbins,7th ed, p. 71; Ananthanarayan, 7th ed, p. 144; Table 16-2TNF and IL1 are the main mediators of inflammation. They are produced mainly by the activated macrophages.Cytokines and their main sourcesILl, IL 8- MacrophagesIL 2, 3, 9, 10, 12, 13- T cellsIL 4, 5, 6- Helper cellsIL 7, 11- Stromal cells 7 spleen alsoIFN a- Leucocyte - MHC 1 - activate NK cellsIFNb- Fibroblast - MHC 1 - activates NK cellsIFN g- T cell - MHC 1 2 - Ag presentationTNF a- Macrophage MonocyteB for both TNF b- T cellsLIF-T TGF b- Both B T cells LIF- T cells 