<prompt> a 25 year old female presented to the hospital on 3rdday of menstruation with complaints of high fever vomiting and rash on her trunk and extremities. on investigations she had leukocytosis and negative blood culture. she is diagnosed as :staphylococcal food poisoningscalded skin syndrometoxic shock syndromevaricella zoster infection  <response>: TOXIC SHOCK SYNDROME Toxic shock syndrome TSS is an acute, febrile illness produced by a bacterial exotoxin, with a fulminating downhill course involving dysfunction of multiple organ systems. It is not unusual for the syndrome to develop from a site of bacterial colonization rather than from an infection. A woman with TSS may develop rapid onset of hypotension associated with multiorgan system failure. Medical Management IV fluids to stabilize blood pressure IV antibodies to fight source of infection For GAS infection- clindamycin 600 mg -900 mg IV 8h Or combined therapy, in which penicillin G 4 million U IV 8h is combined with clindamycin. ref : ananthanaryana 9th ed 