<prompt> A Young boy presents with multiple flaccid bullous lesions over trunk with some oral mucosal lesions. Most likely finding on immunofluorescence study of the biopsy specimen would beFishnet IgG deposits in epidermisLinear IgG in DepositsLinear IgA in dermal papillaeGranular IgA in reticular dermis  <response>: Pemphigus Vulgaris Bullous pemphigoid Autoantibodies against Desmosomal proteins Hemidesmosomal proteins Age 40-60 yrs 60-75 yrs Initial site Oral mucosa Lower extremities Bullae Flaccid Tense Pruritus Mild- Nonexistent or severe Nikolskys sign - Mucosal involvement in almost all patients - 10-40 only HPE Suprabasal acantholytic blisters Tombstone appearance Q Subepidermal blisters eosinophil-rich dermal infiltrate DIF IgG C3 deposits at the intercellular substance of epidermis Fishnet appearanceQ IgG, C3, and IgAIgM at BM zone. IIF Circulating IgG antibodies to the intercellular substance of epidermis. Anti-BM zone antibodies IgG Rx Steroids immunosuppressants Dapsone Gold Steroids Immunosuppressants Dapsone Postinflammatory Hyperpigmentation - Ref. Harrisons 19th ed. Table 55-1 