<prompt> Lewis body is characteristically is seen inParkinsonismPicks diseaseAzlheimers diseaseNeiman Pick disease  <response>: A Parkinsonism Parkinsonism: Pathologically, it is characterized by development of abnormal proteinaceous alpha-synuclein cytoplasmic inclusions, called Lewy bodies, throughout the brain. These inclusions have similar structural features to classical Lewy Bodies seen subcortically in Parkinsons disease LBs have a high concentration of a- synuclein and are pathologic hallmark of parkinsons disease Dementia with Lewy Bodies DLB exhibits clinical overlap between Alzheimers disease and Parkinsons disease Additionally, there is a loss of dopamine-producing neurons in the substantia nigra similar to that seen in Parkinsons disease, and a loss of acetylcholine-producing neurons in the basal nucleus of Meynert and elsewhere similar to that seen in Alzheimers disease. Cerebral atrophy or shrinkage also occurs as the cerebral cortex degenerates. Autopsy series have revealed that the pathology of DLB is often concomitant with the pathology of Alzheimers disease. That is, when Lewy Body inclusions are found in the cortex, they often co-occur with Alzheimers disease pathology found primarily in the hippocampus, including: neurofibrillary tangles abnormally phosphorylated tau protein, senile plaques deposited beta-amyloid protein, and granulovacuolar degeneration. 