<prompt> Which of the following drugs is used for the treatment of multiple sclerosis?Interferon-alphaInterferon-betaInterferon-gammaInfliximab  <response>: Ans. is b i.e. Interferon - beta Treatment of multiple sclerosis o Multiple sclerosis is an autommune disease characterized by chronic inflammatory demylination that affects the CNS. o The most common course of the disease is the relapsing-remitting subtype, which is characterized by unpredictable acute attacks relapses followed by periods of relative remission with no new signs of disease activity. The other type less common is progressive subtype, which is characterized by a steady functional decline from disease onset. o Therapy for MS can be divided into several categories:? 1. Treatment of acute attack Coicosteroids Methylprednisolone, prednisolone are used 2. Treatment with disease-modifing agents that reduce the biological activity of MS Disease modifying agents for multiple sclerosis are iIFN-f1 la; ii IFN-fl lb, iii Glatiramer; iv Natalizumab; v Finoglimod: vi Mitoxantrone; vii Cladaribine. 3. Other treatment options Other off-label treatment options are i methotrexate; ii cyclophosphamide; iii IV immunoglobulins; iv azathioprine. 4. Symptomatic Treatment It includes healthy diet, regualr exercise, and: i Treatment of rigidity baclofen, diazepam, tizanidine, dantroline ii Treatment of weakness Potassium channel blockers like 4-aminopyridine iii Treatment of pain by anticonvulsants carbamezapine, phenytoin, gabapentin, pregabalin, or antidiepressants mexiletin. iv Treatment of UTI, bladder dysfunction, constipation, depression, fatigue and cognitive problems. 