<prompt> Cytogenetics for synol cell sarcoma is -t X : 18t 17, 9t 9, 22t11,14  <response>: Ans. is a i.e., t X:18 Synol cell Sarcoma SCS Synol cell sarcoma forms about 10 of all soft tissue sarcomas. o Although the name suggests an origin from the synol linings, less than 10 of them are intra-aicular. o Most synol sarcomas show a characteristic chromosomal translocation t X : 18 producing SYT-SS X1 or-SS X 2 fusion genes.The specific translocation is associated with poor prognosis 60-70 of SCS involve the lower extremities especially around knee and thigh. o Histologic hallmark of biphasic synol sarcoma is the dual lining of differentiation of the tumor cells eg. epitheliat like and spindle cells o Calcified concrections can be present on X-rays. o This tumor is positive for i Keratin ii Epithelial membrane antigen. 