<prompt> Which of the follwing statements about Pancreatic Carcinoma is not trueMutation in P53 gene is associated in 75 of casesHereditary Pancreatitis significantly increases the riskMedian survival in locally advanced stage III disease is 3-6 monthsFive year survival after curative pancreatico duodenectomy is 15-20  <response>: .Carcinoma pancreas is higher in men. It is common in African American males. 80 of pancreatic cancers are metastatic at the time of first diagnosis. It is common in Jewish heritage and native Hawaiians. Its incidence is 9 new cases per 100000 people. Mean age is 60-65 years. Etiology- Smoking High energy diet rich in fat. Chronic pancreatitis. Familial pancreatitis. Diabetes mellitus. Carcinogens like benzidine. Hemochromatosis with pancreatic calcification. Cirrhosis, obesity. Occupational exposure to carcinogens like DDT,benzidine. Peutz - Jegher syndrome, HNCC Hereditary Non polyposis Colonic Cancer - Lynch II type, ataxia telangiectasia, hereditary breast and ovarian cancers, hereditary atypical multiple mole melanoma syndrome. ref:SRB;S manual of surgery,ed 3,pg no 630 