<prompt> After Phase II reaction the drug shows:Less bioreactiveIncreased bioavailabilityIncreased water solubilityIncreased lipid solubility  <response>: Ans: c Increased water solubilityRef: KD Tripathi 6th ed. Pg. 24-25Phase II reactions makes the drug more water souble and is easily excreted in urine or bile.Biotransformation reactionsPhase I: It is also called nonsynthetic or functionalization reaction. In this reaction a functional group is exposed or generated.Eg: Oxidation: Eg - Hydroxylation most important oxidation reaction is by cytochrome P 450ReductionHydrolysisPhase II: It is also called synthetic or conjugation reaction. These reactions involve conjugation of the M drug or phase I metabolite with an endogenous substance to form a polar highly ionized and water soluble organic acid which is easily excreted in urine. Eg - Glucuronide conjugation Acetylation Methylation Sulfate conjugation Glycine conjugation Glutathione conjugation Nucleotide synthesis After phase II reaction most of the metabolite become inactive except morphine and minoxidil, so the a choice is partially correct. But the most appropriate answer is that phase II reaction increases their water solubility. 