<prompt> Major protein of bone is ?OsteocalcinOsteopontinCollagen type- 1Collagen type- 4  <response>: Ans. is c i.e., Collagen type-1 Bone is a specialized connective tissue. Bone components are :? 1 Inorganic elements 65 2 Organic matrix 35 1Inorganic elements It is the mineral phase, principally composed of calcium and phosphate, mostly in the form of hydroxyapatite . 2Organic maxtix Organic matrix consists of cells of bones and protein of matrix. This unminerilized matrix is called osteoid, i.e. unminerilized bone is known as oteoid. Osteoid with mineral i.e. mineralized osteoid is complete bone. A Protein of matrix It is mainly formed by type I collagen and a family of noncollagenous proteins like osteocalcin and osteonectin that are derived mainly from osteoblasts. B Cells of matrix The cells of bone are :- i Osteoblasts ii Osteoclasts iii Osteocytes 