<prompt> The tumor suppressor gene p53 induces cell cycle arrest at:G2-M phaseS-G2 phaseG1-S phaseG0 phase  <response>: G1S check-point is controlled by p53 whereas G2M check-point has both p53 dependent as well as independent mechanisms. p53 induces the synthesis of p21 which inhibits cyclin DCdk4. This results in stoppage of activation of Rb and cell cycle is arrested in G1S phase. Fig:- Role of P53 in maintaining the integrity of the genome 