<prompt> Gene for the ryanodine receptor, mutation in which is responsible for malignant hypehermia is located on which chromosome-Chromosome 19Chromosome 17Chromosome 18Chromosome 16  <response>: Malignant hypehermia is a geneticautosomal dominant hypermetabolic muscle disease. Malignant hypehermia is a genetic disorder; there is a defect in the gene that codes for the protein ryanodine receptor RyR in skeletal muscle. Ryanodine receptor is a Ca2-release channel present in the membrane of L-tubule of skeletal muscle. When it couples with dihydropyridine receptor DHPRfrom T Tubules , there is release of Ca2 into the sarcoplasm, initiating muscle contraction.So Increased Ca transpo L-type calcium channels in T-tubules leads to malignant hypehermia DHPR is an L-type voltage-sensitive Ca2 channel. Rarely inhalational anaesthetics can cause A malignant hypehermia manifesting as muscle rigidity, sweating and masseteric spasm 