<prompt> When nitrates are combined with calcium channel blockers:Aerial pressure will decreaseHea rate will increaseEjection time will decreaseEnd-diastolic volume will increase  <response>: Nitrates primarily decrease preload, while CCBs have a greater effect on afterload. Their concurrent use may decrease cardiac work to an extent not possible with either drug alone. This combination may be especially valuable in severe vasospastic angina. Eg for nitrates: GTN CCBs-amlo,felo,clevidipine, verapamil, diltiazem K D Tripathi: essentials of medical pharmacology; edition 6; pg no:533 