<prompt> In oesophageal ca which Neoadjuvant chemotherapy is used -CisplatinCyclophosphamideDoxorubicinMethotrexate  <response>: Sabiston writes-Since its introduction in 1980, cisplatin has emerged as the cornerstone of combination therapy in esophageal cancer.As a single agent, it has a response rate of 25 to 30. Given in combination with 5-fluorouracil, a response rate of 50 may be achieved, and this is an established chemotherapeutic regimen for esophageal cancer. 