<prompt> Episodic hypertension is classical feature ofAdrenal carcinomaPheochromocytomaConns syndromeCushings disease  <response>: Ans. b Pheochromocytoma Ref H-17th12270; Table 337-1The dominant sign of Pheochromocytoma is hypertension. Classically, patients have episodic hypertension, but sustained hypertension is also frequent. These paroxysms generally last less than an hour and may be precipitated by surgery positional changes,exercise, pregnancy, urination particularly bladder pheochromocytomas, and various medications e.g., tricyclic antidepressants, opiates, metoclopramide.PHEOCHROMOCYTOMAClinical FeaturesThe clinical presentation is so variable that pheochromocytoma has been termed the great masquerader. Among the presenting symptoms, episodes of palpitations, headaches, and profuse sweating are typical and constitute a classic triad.To enlist:HeadachesWeight lossSweating attacksParadoxical response to antihypertensive drugsPalpitation and tachycardiaPolyuria and polydipsiaHypertension, sustained or paroxysmalConstipationAnxiety and panic attacksOrthostatic hypotensionPallorDilated cardiomyopathyNauseaErythrocytosisAbdominal painElevated blood sugarWeaknessHypercalcemiaPheochromocytoma, DiagnosisDiagnostic MethodSensitivitySpecificity24-h urinary tests Vanillylmandelic acidCatecholaminesFractionated metanephrinesTotal metanephrinesPlasma CatecholaminesFree metanephrinesPlasma Chromogranin ACTMRIMIBG scintigraphySomatostatin receptor scintigraphyDopa dopamine PET preliminary data 