<prompt> A new born presented with bloated abdomen sholy after bih with passing of less meconium. A full thickness biopsy of the rectum was carried out. Which one of the following rectal biopsy findings is most likely to be present -fibrosis of submucosaHyalinisation of the muscular coatThickened muscularis propriaLack of ganglion cells  <response>: Ans. is d i.e. lack of ganglion cells The diagnosis of Hirschprungs disease is suspected in this neonate, which is confirmed on rectal biopsy by the finding of - lack of ganglion cells. 