<prompt> Not a marker for muscle tumor ?DesminActinNeurofilamentIntermediate filament  <response>: Ans. is c i.e., Neurofilament Markers for smooth muscles tumor are : i Muscle specific actin, ii Intermediate filament, and iii Desmin. Neurofilament is a marker of neural tumors. Immunohistochemistry Immunohistochemistry is a method of analyzing and identifying cell types based on binding of antibodies to specific components of the cell. Antibody, which is specific for an antigen of a paicular tissue, is labled with a probe coloured marker and is run on the tissue specimen obtained from a biopsy. If the tissue has that paicular antigen, then antibody will get attached to the tissue and the labled antibody can be seen under a microscope. Intermediate filaments of cytoskeleton are the major antigens used in immunohistochemistry. There are five major types of intermediate filaments - Cytokeratin Carcinoma, mesothelioma, Non-seminoma GCT Vimentin Sarcoma Tumor of mesenchymal, melanoma, seminomas, lymphoma Neurofilament Neural tumors Glial fibrillary acid Non-neural brain tissue astroglial origin-3 Astrocytoma, ependymomas, proteins GFAP medulloblastoma, oligodendroglioma Desmin Leiomyoma smooth muscle Rhabdomyoma skeletal ms. 