<prompt> All true about - cocaine except-It is amide local anestheticsIt can produce sympathetic stimulationIt is metabolized by liverIt blocks the presynaptic uptake of norepinephrine and dopamine  <response>: It is ester local anesthetics Cocaine was the first local Anesthetic to be used clinically. It is only natural local anesthetic. Koller introduced this in the field of ophthalmology. It is the only local anesthetic with vasoconstrictor action. It is sympathomimetic and inhibits metabolism of catecholamine. 