<prompt> Early eiphyseal closure is seen withLHFSHEstrogensProgesterone  <response>: Estrogens: Ref: 1859-Nelson 17thEstrogen has direct result of the known on promoting epiphyseal fusion and therapy must begin before the bone age has reached 12 years Marfans syndrome Recent studies have demonstrated that is estrogen that mediates epiphyseal fusion in both girls and boys Androgens also accelerates skeletal maturation, presumably via aromatization to estrogens, but at the price of rapid virilization. 