<prompt> High plasma protein binding of a drug results in:-Decreased glomerular filtrationHigh volume of distributionLowers duration of actionLess drug interaction  <response>: High plasma protein binding PPB of a drug decreases its distribution into tissue and thus lower the volume of distribution. As only free drug can be metabolized or excreted, high PPB usually increases the duration of action. With higher PPB, there is more chance of getting displaced by other drugs leading to more drug interactions. Drugs with high plasma protein binding have lesser glomerular filteration as proteins cannot be filtered across the glomerulus. 