<prompt> Which of the following cytokines is associated with the development of cell-mediated immunity?IL-3IL-4IL-5IL-I2  <response>: Gamma interferon from T helper 1 CD4 lymphocytes and IL-12 from macrophages are major stimulators of the development of a cell-mediated immune response to intracellular organisms such as tuberculosis, leishmaniasis, histoplasmosis, and many other organisms. IL-3 is a cell growth factor produced by thymic epithelial cells and T cells to regulate different T cell differentiation processes. IL-4 is produced by T helper 2 CD4 lymphocytes and is involved in class switching to IgE. It also downregulates T helper 1 CD4 lymphocytes. IL-5 is produced by T helper 2 CD4 lymphocytes and is involved in IgA production, eosinophil differentiation, and B cell differentiation. Ref: Brooks G.F., Carroll K.C., Butel J.S., Morse S.A., Mietzner T.A. 2013. Chapter 8. Immunology. In G.F. Brooks, K.C. Carroll, J.S. Butel, S.A. Morse, T.A. Mietzner Eds, Jawetz, Melnick, Adelbergs Medical Microbiology, 26e. 