<prompt> Fluroquinolone mechanism of action in gram positive organism is by ?DNA gyraseTopoisomerase IITopoisomerase IIITopoisomerase IV  <response>: Ans. is d i.e., Topoisomerase IV Fluroquinolones Fluoroquinolones including ciprofloxacin inhibit DNA gyrase and topoisomerase IV. For gram negative bacteria, the primary target is DNA gyrase, while topoisomerase IV is inhibited in gram positive bacteria. 