<prompt> What is the mode of inheritance of Hereditary spherocytosis?Autosomal dominantAutosomal recessiveX-linked recessiveX-linked dominant  <response>: - Hereditary spherocytosis is inherited in an Autosomal dominant pattern. - Results from instability of spectrin ankyrin which are major skeletal membrane proteins. - Degree of protein deficiency correlates with degree of hemolysis. - Demonstrated by Increase in osmotic fragility after 24hrs incubation of blood at 37oC. 