<prompt> All of the following are true for Korsakoffs psychosis except: March 2010Organic amnestic syndromeLoss of insightDeficiency of cyanocobalaminIt may follow Wernickes encephalopathy  <response>: Ans. C: Deficiency of cyanocobalamin Korsakoffs psychosisamnesic-confabulatory syndrome is a neurological disorder caused by the lack of thiamine vitamin B1 in the brain. There are six major symptoms of Korsakoffs syndrome: Anterograde amnesia and Retrograde amnesia, severe memory loss Confabulation, that is, invented memories which are then taken as true due to gaps in memory sometimes associated with blackouts Meager content in conversation Lack of insight Apathy - the patients lose interest in things quickly and generally appear indifferent to change. These symptoms are caused by a deficiency of thiamine, which is thought to cause damage to the medial thalamus and possibly to the mammillary bodies of the hypothalamus as well as generalized cerebral atrophy. When Wernickes encephalopathy accompanies Korsakoffs syndrome, the combination is called the Wernicke-Korsakoff syndrome. Korsakoffs is a continuum of Wernickes encephalopathy, though a recognised episode of Wernickes is not always obvious. Korsakoffs involves damage to neurons; gliosis which is a result of damage to suppoing cells of the central nervous system; and hemorrhage or bleeding in mammillary bodies. 