<prompt> Most common cause of nephrotic range proteinuria in an adult is-Diabetes MellitusAmyloidosisHypeensive nephropathyWegnersGranulomatosis  <response>: Most common cause of nephrotic syndrome in Elderly people -membranous glomerulonephritismembranous nephropathy. Children-minimal change disease Most common cause of chronic renal failure is DIABETIC NEPHROPATHY . Pathological changes seen -mesangial sclerosis ,eosinophilic PAS nodules called -kimmelsteil wilson nodules Immunofluorescence-non specific deposition of IgG and complement. On Electron microscopy-no immune deposits are seen. Earliest manifestation of DN-microalbuminuria30-300 mg24 hrs In advanced DN, kidneys are enlarged in contrast to many other Glomerular diseases where kidneys decrease in size. Ref:Harrison 20 th edition pg no. 2144 