<prompt> Which of the following statements is TRUE regarding termination of action of a drug?Drugs must be excreted from the body to terminate their actionMetabolism of drugs always abolishes their pharmacologic activityHepatic metabolism and renal excretion are the two most impoant mechanisms involvedDistribution of a drug out of blood stream terminates the drugs effects  <response>: Action of a drug can be terminated either by hepatic metabolism or by renal excretion. Other pathways like excretion in sweat or saliva plays minor roles. Most of the drugs are inactivated by metabolism. However, some drugs may be activated from inactive form prodrugs and others may produce active metabolites. Some drugs may act away from blood e.g. digoxin leaves bloodstream and enters the hea to produce its action. 