<prompt> Which of the following aminoglycoside is cochleotoxic:KanamycinStreptomycinGentamycinMinocycline  <response>: Ref: Goodman Gillman 13th ed. P 1044-45 All aminoglycosides have the potential to produce reversible and irreversible vestibular, cochlear, renal toxicity and neuromuscular blockade. Aminoglycoside-induced ototoxicity may result in irreversible, bilateral, high-frequency hearing loss or vestibular hypofunction. A high-pitched tinnitus often is the first symptom of cochlear toxicity. Drugs like amikacin, neomycin and kanamycin are specifically cochleotoxic vestibulotoxic. Gentamicin, streptomycin is vestiblar cochleotoxic Tobramycin: Cochlear Vestibular toxicity both. 