<prompt> Most common mitochondrial enzyme for metabolism detoxification reaction is ?CYP 3A4CYP 1A2CYP 2A6CYP 2B6  <response>: Ans. is a i.e., CYP 3A4 Subtypes of cytochrome P-450 Depending upon the extent of amino acid sequence homology, the cytochrome P-450 CYP isoenzymes are grouped into families designated by capital letters A, B, C .... Individual isoenzymes are again alloted numerals 1, 2, 3 .... Examples are CYP1A2, 2A6, 2B6, 2C8, 3A43A5. In human beings, only a few members of three isoenzyme families carry out metabolism of most of the drugs. Cyp 3 A 45 carryout biotransformation of largest number nearly 50 of drugs. Impoant inducers of CYP 3A43A5 Barbiturates Glucocoicoids Rifampin Macrolide antibiotics Carbamazepine Phenytoin Pioglitazone 