<prompt> The following hormone does NOT have any intracellular receptor:Vitamin D3CoisoneAdrenalineThyroxine  <response>: Cell membrane receptor proteins are located within the phospholipid bilayer of the cell membrane of target cells. Binding of hormones ie, catecholamines, peptide and protein hormones to cell membrane receptors and formation of the hormone-receptor complex initiates a signaling cascade of intracellular events, resulting in a specific biologic response. Intracellular receptors are transcription factors that have binding sites for the hormone ligand and for DNA and function as ligand hormone-regulated transcription factors. Steroid hormones and the steroid derivative vitamin D3 fulfill this requirement. Thyroid hormones must be actively transpoed into the cell. Ref: Molina P.E. 2013. Chapter 1. General Principles of Endocrine Physiology. In P.E. Molina Ed, Endocrine Physiology, 4e. 