<prompt> Lack of leucocyte adhesion molecules LAM is associated with:Delayed fall of umbilical cordNormal chemotaxisComplement opsonizationNeutropenia  <response>: a. Delayed fall of umbilical cordRef: Nelsons 20e p 1027, Ghai 8e p 187Leukocyte adhesion deficiency LADSalient featuresLAD type 1LAD type 2InheritanceAutosomal recessiveAutosomal recessiveBasic defectDefect in CD 18 moleculeQ required for biosynthesis of B2 chain shared by LFA-1 Mac-1 integrinsAbsence of Sialyl-Lewis X, the fucose-containing ligand for P E-selection, due to defect in fucosyl-transferase responsible for binding fucose moieties to protein backbonesClinical featuresRecurrent bacterial infections, delayed separation of umbilical cord stumpQRecurrent bacterial infections, Bombay blood groupQ and mental retardation 