<prompt> IN activated protien C resistent disorder due to inactivation ?factor 8factor 5factor 13factor 4  <response>: Factor V Leiden mutation Factor V Leiden is an autosomal dominant condition that exhibits incomplete dominance and results in a factor V variant that cannot be as easily degraded by activated Protein C. The gene that codes the protein is referred to as F5. Mutation of this gene is a single nucleotide polymorphism located on chromosome 1 in exon 10 As a missense substitution it changes a protein;s amino acid from arginine to glutamine. ref : robbins 10th ed 