<prompt> A 1 cm x 1 cm squamous cell carcinoma of anal canal is best treated initially byAbdominoperineal resectionLocalized resection followed by irradiationProximal colostomy followed by interstitial irradiationChemo-radiotherapy  <response>: Anal cancer: Treatment is by chemoradiotherapy in the first instance Associated with HPV More prevalent in patients with HIV infection May affect the anal verge or anal canal Lymphatic spread is to the inguinal lymph nodes Uncommon tumour, which is usually a squamous cell carcinoma Major ablative surgery is required if the above fails Ref: Bailey Love;s Sho Practice of Surgery,E25,Page-1269 