<prompt> First line therapy in smoking dependence:Nicotine replacement gumRimonabantNaloxoneAcute cessation  <response>: Ref: Katzung, 14th ed. pg. 584Treatment of smoking dependence: First line: Nicotine replacement therapy gum, patch, inhaler. Bupropion and Varenicicline Nicotine receptor agonist: Also, first line. Considered more effective. 2nd line: Clonidine and Nortryptiline Rimonabant: Cannabinoid receptor inverse agonist. Withdrawn due to increased depression and suicide risk. 