<prompt> Enzyme inactivation is the main mode of resistance toAminoglycosidesQuinoloneRifampicinGlycopeptides  <response>: Refer KDT 6e p 720 Resistance to quinolone is due to altered DNA gyrase, to Rifampicin is due to mutation in gene rpo! Reducing its ability for the target and for glycopeptides like vancomycin due to reduced affintiy6 for target site 