<prompt> Wide neuralforamina is associated with:Neurofibromatosis type 1Sturge-Weber syndromeVon Hipple Lindau diseaseTuberous sclerosis  <response>: A i.e. Neurofibromatosis Neurofibromatosis type 1 is associated with widening enlargement of neural foraminaQ mostly secondary to dumbbell neurofibroma along exiting spinal nerve root or less commonly dt dural ectasia, arachnoid cyst or lateral menngoceleQ, scalloping of posterior veebral bodies, enlargement of internal auditory canal dt dural dysplasia, enlargement of optic foramen dt optic glioma, enlargement of orbital margins superior orbital fissure dt plexiform neurofibroma and sclerosis of optic foramen dt optic nerve sheath meningioma. NF1 causes empty orbitQ, Herlequin appearance of orbit and herniation of middle cranial fossa structures into orbit dt sphenoid bone hypoplasia. Both neurofibromas common in NF1 and Schwannomas common in NF2 are benign nerve sheath tumors mostly found in intradural extramedullary location. Both are derived from Schwann cells, however, neurofibromas also have colagen fibroblasts. Vestibular or acoustic Schwannoma or neurilemmoma or acoustic neuroma of 8th cranial nerve seen in NF2 1t internal auditory canal IAC enlargement erosion dt mass centered on long axis of IAC forming acute angles with dural surface of petrous bone and widening or obliteration of ipsilateral cerebello pontine angle cistern. NF-2 is located on chromosome 22 and NF1 on chromosome 17Mn 1 for 1 2 for 2. NF2 have propensity for developing MENMES i.e. meningioma, ependymoma gliomas and Schwannoma neuromas. Nerves without Schwann cells are olfactory and optic nerve. Schwannomas neurofibromas, on CT, appear as sharply marginated, unilateral, spherical, or lobular posterior mediastinal mass, with pressure erosion of adjacent rib or veebral bodies or enlargment of neural foramen with occasional punctate intralesional calcifcation. Owing to their high lipid content, interstitial fluid and areas of cystic degeneration - Schwannomas are often of lower attenuation than skeleton muscle. Neurofibromas are often more homogenous of higher attenuation than schwannomas owing to fewer of above histological features. These may heterogenously enhance on contrast administration. On MRI both show variable intensity on T1WI but typically have similar signal intensity to the spinal cord. On T2WI these characteristically have high signal intensity peripherally and low signal intensity centrally target sign owing to collagen deposition. Both schwannoma neurofibroma enhance on gadolinium administration. 