<prompt> Which of the following can recognize dead material?NETInflammasomeNecrosisToll-like receptor  <response>: Ans. B. InflammasomeNOD-like receptors NLRs and the inflammasomeLocationCytosolic receptorsRecognizeNecrotic cells, ion disturbances e.g., loss of k, urate crystal, and some microbial productsMechanism of actionActivates Caspase-1- activates IL-1- recruits leukocytes and induces feverRole in diseases Periodic fever syndromes autoinflammatory syndromes: Due to gain of function mutations Obesity associated type 2 diabetes and atherosclerosis: Due to gain of function mutations Inflammation in gout: Due to recognition of urate crystals by a class of NLRs 