<prompt> Longest acting beta blokeris ?NodalolEsmololCarvedilolAcebnolol  <response>: Ans. is a i.e., Nodalol Nodalol is longest acting b-blocker. Esmolol is shoest acting b-blocker. Remember Nodalol is longest acting P-blocker. Esmolol is shoest acting n-blocker Acebutolol possesses all activities i.e., cardioselectivity, paial agonist activity, membrane stablizing activity and lipid insolubility. Beta blockers approved for treatment of CHF : Carvedilol most widely used, metaprolol, bisoprolol. Carvedilol is a 13 132 al adrenoreceptor blocker with a : i3 blocking propey of I : 9. It produces peripheral vasodilatation due to a-1 blockade as well as calcium channel blockade direct effect. Atenolol, sotalol and nodalol are primarily excreted by kidney - should not be given in renal failure. Sotalol, penbutolol and pindolol have almost 100 bioavailibility. Penbutolol has maximum oral absorption. Carvedilol has maximum plasma protein binding. Celiprolol has minimum plasma protein binding. 