<prompt> A 8 yr old boy presents with petechie, azotemic oligurea altered sensorium in casualty. There is history of diarrhoea for the past 5 days. The clinical diagnosis is -Acute prophyriaIdiopathic thrombocytopenic purpuraH.S. purpuraH.U.S.  <response>: Ans. is a i.e., Hemolytic uremic syndrome The boys is suffering from hemolytic uremic syndrome. Hemolytic uremic syndrome HUS is characterized by the triad of - 1 Anemia microangiopathic hemolytic anemia 2 Renal failure microangiopathy of kidney involving glomerular capillaries and aerioles. 3 Thrombocytopenia due to platelet destruction o HUS is common in children under 2 years of age. But may also occur in older children. o It usually follows an episode of acute gastroenteritis. o The prodrome is usually of abdominal pain, diarrhoea and vomiting. Sholy thereafter, signs and symptoms of acute hemolytic anemia, thrombocytopenia and acute renal failure ensue. o Sometimes neurological findings also occur But usually absent and differentiates HUS from TTP. 