<prompt> Adult patient presents with generalized lymphadenopathy and blood film shows 70percent immature looking lymphocytes. What should be the next best investigation?GenotypingkaryotypingImmunophenotypingBone marrowPeripheral smear study  <response>: Adult pateint presenting with generalized lymphadenopathy and blood film shows 70percent immature looking lymphocytes is highly suggestive of chronic lymphocytic leukemia. Immunophenotyping can be one of the best ways to differentiate between CLL and other B cell neoplasms. ref Robbins 9e p593 