<prompt> Polycystic kidney disease is?Autosomal dominantAutosomal recessiveX-linkedMultifactorial  <response>: Description: Feature ADPKD ARPKD 1.Inheritance Autosomal dominant Autosomal recessive 2.Cytogenetic defect Chromosome 16 85: ADPKD-1 Chromosome 4 15: ADPKD-2 Chromosome 6 3.Mutations PKD 1 gene 85 PKD 2 gene 15 6p21 PKHD1 4.Age at presentation Adults 3rd to 5th decades Infancy, perinatal 5.GA Macrocysts Cysts derived from all pas of the nephronglomeruli, tubules Micro- and macrocysts radiating from the medulla to OUTER COEX 6.Other manifestations Intracranial aneurysms, cysts of other organs None Ref: HARSH MOHAN TEXTBOOK OF PATHOLOGY 6th ed. pg no: 659 