<prompt> Deletion of short arm of 5th chromosome is___ syndromeEdwardPatauCri-Du-ChatDowns  <response>: Ans. c Cri du chat Ref. Harrisons Internal medicine 17th edition, p. 412; Robbins pathology 7th edition, p. 177Cri-du-chat syndrome: Congenital microdeletion of short arm of chromosome 5 46, XX or XY, 5p-. Findings: microcephaly, moderate to severe intellectual disability, high-pitched cryingmewing, epicanthal folds, cardiac abnormalities VSD.Location of diseases on chromosomesDiseasesDeletionWolf-hirschorn syndrome4p-Cridu chat5p-DiGeorge syndrome22q-Cat-cry syndrome22p-Miller-Dieker17p-a-thalassemia16p -Angelman Syndrome15q - angel ... maternal MamaPrader-Willi Syndrome15q - paternal ... P ... PapaRetinoblastoma13q 14 -Beckwith-Wiedemann syndrome11 pl5 -WAGAR11 pl3 -Downs syndromeTrisomy 21PatauTrisomy 13Edwards syndromeTrisomy 18Educational Points:22q 11 deletion associated with high incidence of schizophrenia Harrisons 17th edition, p. 2075; Robbins, 178TrisomyCardinal featuresTrisomy 13 Patau syndrome Auricular deformities Microcephaly Arrhinencephaly Inner ear anomalies Ocular anomalies Hypertelorism Cleft lip and palate VSD Simian creaseTrisomy 18 Edward syndrome Auricular deformities Inner ear anomalies Ptosis of eyelids Micrognathia Flexion deformities Mental retardationTrisomy 21 Downs syndrome Auricular deformities Hypertelorism Epicanthal fold Protruding tongue High arched palate Inner ear anomalies Cardiovascular defects Mental retardation 