<prompt> Prevention of neural tube defect in the newborn is byIronB6B12Folic acid  <response>: Folic acid: 865 H186th edition Folic acid supplementation of the time of conception and in the first 12 weeks of pregnancy reduce by -70 the incidence of neural tube defects NTDs Anencephaly , meningomyelocele,encephalocele and spina bifida in the fetus. Most of this protective effect can be achieved by taking folic acid 0.4mg daily at the time of conception The incidence of cleft palate and have lip also can be reduced by prophylactic folic acid NTDs also can be caused by antifolate and antiepileptic drugs 