<prompt> Which of the following drug is a SERM useful for treatment of osteoporosis?RaloxifeneBisphosphonateStrontiumEstradiol  <response>: Ans. A RaloxifeneRef: Katzung, 11e p759; Goodman and Gilman, 11e p1557; KDT 8e p339Raloxifene is a selective estrogen receptor modulator with estrogen agonistic action on bone and antagonistic action on breast and endometrium. It is therefore the preferred drug for the treatment and prevention of post-menopausal osteoporosis. Major adverse effect of this agent is increased risk of thromboembolism. 