<prompt> Hand, foot mouth syndrome is caused by ?CisplatinMethotrexate5 FUMetycergide  <response>: Ans. is c i.e., 5FU Hand foot syndrome Hand foot syndrome is a form erythromyelalgia manifested as tingling, numbness, pain, erythma, swelling and increased pigmentation of hands and feet. Two most common drugs causing Hand foot syndrome are: Capecitabine most common 5-FU 2nd most common Drugs causing Hand foot syndrome Commonly associated drugs Capecitabine Surafenib Cytarabin 5-FU Doxorubicin liposomol Rarely associated drugs Cisplatin Etoposide 6-MP Cyclophosphamide Hydroxyurea Suramin Docetaxel Methotrexate Paclitaxel Daunorubicin Mitotane 