<prompt> Skin pigmentation icthyosis like side effects are seen in:RifampcinClofazimineDapsoneSteroid  <response>: B i.e. Clofazimine Dapsone Dose and side Effects Dose is 1-2mgkgQ and half life is 24 hoursQ. Clinical response is seen at doses ranging from 25-200mgday but rarely requiring 300mgd. Doses of 100mg in healthy persons and 50mg in healthy individuals with a G6PD deficiency do not cause hemolysis. Sulfones tend to be retained in skin, muscle and especially in lever and kidney for upto 3 weeks. Intestinal reabsorption of sulfones excreted in bile contributes to long term retention in blood stream. G6PD protects RBCs against oxidative stress. Dapsone an oxidant causes severe hemolysis Vt haemolytic anemia most common side effectQ in patients with G6PD deficiency. Hemolysis and methemaglobinemia develops in almost every individual treated with 200-300mg of dapsone per day. MethemoglobinemiaQ also is common and may be severe in NADH-dependent methemoglobin reductase deficiency. Idiosyncratic or allergic like distal peripheral neuropathy almost always motor occasionally with a sensory component; which is reversible with dose decrease or discontinuation. Sulfone syndrome Mono nucleosis like hypersensitivity usually develops between 2 and 7 weeks after staing drug and inevitably includes the triad of fever, rash exfoliative or SJ like and hepatitis. Agranulocytosis, leukopenia severe hypoalbuminea are other S Es. Theraputic uses Infections: DDS is effective against M.leprae, MAC, M.kanssii bacteria; plasmodium falciparum and toxoplasma gondii parasites; and pneumocystic jiroveci fungus and so is used in LeprosyQ MalariaQ combined with chlor proguani ActinomycosisQ, rhinosporidosis, P. jiroveci infection and prophylaxis, and P. Carinii pheneumonia prophyloxis in sulfa allergic immuno compromised patients, and for T. gondii prophylaxis. Non-infections diseases with consistent response to dapsone include Dermatitis herpetiformis drug of choiceQ Erythema elevatum diutinum, linear immunoglobuline A dermatosis chronic bullous dermatosis of childhood and bullous eruption fo SLE. Other non-infectious conditions in which DDS has found sporadic less rapid, regular or predictable success have a unifying feature of having granulocytes neutrophils or eosinophils as the predominant infiltrating cell. Examples are: Collagen vascular disease e.g. RA, rheumatoid papules, relapsing plychondritis, subacute cutaneous lupus erythematosus, chronic cutaneous lupus, lupus profundus; various vasculitides including cutaneous PAN, HS purpura, chronic leukocytoclastic vasculitis without internal organ involvement and Bechet syndrome. Autoimmune diseases e.g. steroid resistant or dependent ITP, bullous pemphigoid, cicatricial mucous membrane pemphigoid, paicularly in early inflammatory phase of ocular disease, sobcorneal pustular dermatoses, pemphigus vulgarisfoliaceaous and uicarial vasculitis. - Inflammatory conditons like acne vulgaris and acne conglobate but is not recommended. 