<prompt> Mechanism of action of beta-blockers in glaucoma isIncreases uveo-scleral out flow of aqueousIncreases trabecular mesh work out flowDecreaes aqueous productionConstant aqueous production in ciliary body  <response>: Decreases aquous formation: Ref: 222-KH, 87-KDTMechanism of actions of beta-adrenergic blockersTimolol and levobunolal are non selective beta 1 Cardiac and beta 2 smooth muscle, pulmonary receptor blockers, causes lower IOP by blockade of beta - 2 rceptors in the ciliary process resulting in decreased aquous production. Betaxolol are thought to increase the perfusion of the optic nerve head 305-P cardio selective Metipranolol: only in preservative free units, it is therefore useful in patients allergic to preservatives or wearing soft contact lens in whom benzolkonium chloride should be avoidedMode of action of ocular hypotensive drugs 87-KDTDrugsclassAqueous secretionTrabecular outflowUveoscleral outflow1. b-blockers Timolol---2. Miotics Pilocarpine----3. Adrenal ineDipi ve fri ne?4. BrimonidineApraclonidine--?5. Prostaglandins latanoprost--?6. Carbonic anhydrase inhibitors--- 