<prompt> LMP 1 gene plays a role in oncogenesis induced byHuman T cell leukemia virus type 1Hepatitis B virusEpstein Barr virusHuman papilloma virus  <response>: Ref Robbins 9e p328 LMP 1 gene plays a role in oncogenesis induced by EBV Epstein-Barr virus latent membrane protein 1 LMP1 is expressed in multiple human malignancies, including nasopharyngeal carcinoma and Hodgkin and immunosuppression-associated lymphomas. LMP1 mimics CD40 signaling to activate multiple growth and survival pathways, in paicular, NF-kB. LMP1 has critical roles in Epstein-Barr virus EBV-driven B-cell transformation, and its expression causes fatal lymphoproliferative disease in immunosuppressed mice. Here, we review recent developments in studies of LMP1 signaling, LMP1-induced host dependency factors, mouse models of LMP1 lymphomagenesis, and anti-LMP1 immunotherapy approaches 