<prompt> Which of the following inhibits Na-K2Cl- cotranspo?MannitolCarbonic anhydrase inhibitorThiazideLoop diuretic  <response>: Potassium-sparing diuretics act by either antagonizing the action of aldosterone spironolactone or by inhibiting Na reabsorption in the distal tubules amiloride. Mannitol is freely filtered at the glomerulus, but in contrast to glucose is not reabsorbed and produces an osmotic diuresis. Clinically it is used to treat cerebral edema and in prerenal azotemia to conve oliguric acute renal failure to non-oliguric acute renal failure. Thiazides inhibit Na and K reabsorption in the distal tubule and loop diuretics furosemide, ethacrynic acid inhibit the Na-K-2Cl cotranspoer in the ascending loop of Henle. Ref: Ives H.E. 2012. Chapter 15. Diuretic Agents. In B.G. Katzung, S.B. Masters, A.J. Trevor Eds, Basic Clinical Pharmacology, 12e. 