<prompt> The ligand-receptor complex dissociates in the endosome becauseOf its large sizeThe vesicle looses its clathrin costOf the acidic pH of the vesicleOf the basic pH of the vesicle  <response>: Ligand-gated channels are opened by binding of effectors. The binding of a ligand to a receptor site on the channel results in the opening or closing of the channel Fig. 2.11. The ligand may be an extracellular signaling molecule or an intracellular messenger.Ref: DM Vasudevan, page no: 15 