<prompt> All are familial breast cancer gene is all EXCEPT?BRCA1P53P16PTEN  <response>: Ans. C P16Ref: Robbiris pathology 9th ed. 1054-55 Genes called BRCA1, BRCA2, TP53 or PTEN are linked with breast cancer. P16 plays an important role in cell cycle regulation by decelerating cells progression from G1 phase to S phase, and therefore acts as a tumor suppressor that is implicated in the prevention of cancers, notably melanoma, oropharyngeal squamous cell carcinoma, cervical cancer, and esophageal cancer. 