<prompt> More than 90 of this drug is excreted in the urine in intact form. Because its urinary solubility is low, patient should be well hydrated to prevent nephrotoxicity. The drug is:IndinavirZidovudineAcyclovirAmantadine  <response>: Ref: Katzung 10e p793; KDT 6e 769 Both indinavir and acyclovir can cause nephrotoxicity bad renal stone formation. But indinavir is metabolized mainly in the liver and acyclovir is excreted unchanged in the urine. 