<prompt> HPV-related cervical intraepithelial neoplasia can be diagnosed by the presence of which of the following histologic features?NOT RELATED-PATHOLOGYCentral, basophilic intranuclear cellular inclusionsCowdry type A intranuclear cellular inclusionsEnlarged multinucleated cellsCytoplasmic vacuolization and nuclear enlargement of cells  <response>: HPV produces characteristic cytoplasmic vacuolization and nuclear enlargement of squamous epithelial cells referred to as koilocytosis. Both Cowdry type A intranuclear inclusions and enlarged multinucleated cells can be seen with herpes simplex virus HSV and varicella-zoster virus VZV infections; central, basophilic intranuclear inclusion bodies are seen in CMV infections, whereas the presence of atypical lymphocytes is seen specifically in Epstein-Barr virus EBV infections. 