<prompt> A 50-year-old woman who was obese and hypertensive, came with complaints of bleeding and abdomen pain, diagnosed to be endometrial cancer. Which of the following gene is mutated?P53PTENBeta cateninCHD4  <response>: Ans: b PTENRef: WHO, FGT, Page 29-34Going with PTEN because its the most common one mutated Ref: WHO - 50. P53 mutation is seen only in type 2 carcinomas, incidence of which is less. PTEN is seen in both type 1 and type 2 carcinomas.FeaturesType 1Type 2Prototypic formEndometrioid carcinomaUterine papillary serous carcinomaTypical patientPerimenopausal or early postmenopausal womenElderly women Background of endometrial hyperplasiaBackground of atrophic endometrium Low-gradeHigh-grade Estrogen-dependentNot estrogen-dependentEstrogen receptorUsually positive; high grade cases may be negativeNegativeMIB1 proliferation index ki-67LowHighp53Negative; high grade cases may be positiveDiffuse positivity 