<prompt> What is the earliest bony change of osteomyelitis on X-rays?Loss of soft tissue planesPeriosteal reactionSequestrum formationLytic defects  <response>: Pyogenic osteomyelitis on X-ray in 24-48 hours will show loss of soft tissue planes earliest change on X-ray. Day 7 to 10-solid periosteal reaction earliest bony change on X-ray. 