<prompt> Gastrointestinal stromal malignancy arises from which of the followingSmooth muscleNerve cellsVascular endotheliumInterstial cells of cajal  <response>: Refer Robbins page no Pg P775 Gastrointestinal stromal tumors GISTs may be malignant cancer or benign not cancer. They are most common in the stomach and small intestine but may be found anywhere in or near the GI tract. Some scientists believe that GISTs begin in cells called interstitial cells of Cajal ICC, in the wall of the GI tract. 