<prompt> Cafe au lait spots seen in?NFGardner syndromeCockayne syndromeDown syndrome  <response>: clinical criteria to diagnose neurofibromatosis include 6 or more cafeaelait macules, 2 or more neurofibromas, Freckling in axillary and inguinal regions, Optic gliomas , 2 or more Lisch nodules, A distinctive osseous lesion, A first degree relative with NF1. Page no 322 Reference IADVLs concise textbook of dermatology 