<prompt> True about methicillin-resistant Staphylococcus aureus MRSA isIsoxazolyl penicillin is highly effectiveAll MRSA are multidrug resistanceVancomycin is effectiveMRSA are more virulent than sensitive strains  <response>: Penicillin resistance may also be due to alterations in penicillin-binding protein PBP2a and changes in bacterial surface receptors, reducing binding of beta-lactam antibiotics to cells. This resistance also extend to cover beta lactamase resistant penicillin such as methicillin and cloxacillinMRSASome of these strains may show resistance to other antibiotics like erythromycin, tetracyclines, aminoglycosides and heavy metals. 