<prompt> The cause of the severe hemorrhage in Acute Promyelocytic Leukemia is?Disseminated intravascular coagulationImmune complex deposits on blood vesselsThrombocytopeniaThrombocytosis  <response>: Ans- a Disseminated Intravascular coagulationRef: Robbins pathology 9th ed. 317-18, 612, 663 Acute promyelocytic leukemia APL is characterized by more severe hemorrhagic phenomena than those of other acute leukemias. The hemorrhagic diathesis results from disseminated intravascular coagulation. About 40 percent of patients with APL have a chromosomal abnormality with translocation from the long arm of 17 to 15 t 15q;17q The patient may present with massive ecchymoses, hematuria, epistaxis, or meno-metrorrhagia. 