<prompt> Iron metabolism and regulation are important for RBC precursor cell. Which of the following helps in regulation of iron metabolism but is not specific for iron?HepcidinDMT-1FerroportinFerritin  <response>: Ans. b DMT-1Ref: Wintrobe 13ed pg 811; Robbins 9th649; Complete review of Pathology 1st314About DMT-1:Mucosal uptake of non-heme iron begins at brush border of mucosal cell, mediated by divalent metal ion transporter 1 DMT1, also known as Nramp2, SLC11A2.Levels of DMT1 are markedly increased in iron-deficient animals.In addition to iron, DMT I has been shown to transport a variety of divalent metal ions, including Mn2,Co2,Cu2,Zn2,Cd2, and Pb2. Hence non -specificIt acts as a proton symporter; protons accompany metal ions into the cell.Hepcidin: principal iron regulatory hormone; and is negatively regulates ferroportin on basolateral surface of enterocyte Q 