<prompt> HER2neu receptor plays a role inPredicting therapeutic responseDiagnosis of breast cancerScreening of breast cancerRecurrence of tumor  <response>: Friends, direct quote from Robbins...HER2neu overexpression is associated with poorer survival but its main importance is as a predictor of response to agents that target this transmembrane protein examples trastuzumab or lapatinib. The overexpression is due to amplification of the gene HER2neu located on 17q21. Ackerman writes... HER2new encodes a transmembrane glycoprotein with tyrosine kinase activity and its overexpression is a good predictor of response to herceptin trastuzumab but not a good predictor of response to chemotherapy or overall survival. 