<prompt> Oxalate crystals in urine is seen in poisoning withMethanolEthylene glycolPotassium dichromateMethylene blue  <response>: Ans: b Ethylene glycolRef: Harrison, 17 ed. pg. 291, Davidson 21 ed. pg.Ethylene glycol poisoning AntifreezeEthylene glycol is metabolized into glycoaldehyde, glycolic acid, glycoxylic acid, oxalic acid causing metabolic acidosis; oxalate causes renal damage due to calcium oxalate crystals in urine.CF: Ophthalmpoplegia, cranial nerve palsies, myoclonus, hyporeflexia renal failureManagement Assay not widely available Diagnosed by the presence of high anion gap, osmolal gap 10 mOsm and presence of oxalate crystals in urine Antidote - Oral ethanol, Fomipazole -Inhibit alcohol dehydrogenase Hemodialysis in severe cases Hypocalcaemia treated only if severe ECG changes seizures present 