<prompt> Drug X normal administered to patients at a rate of 50mghr. Elimination of the drug X from body takes place as Hepatic metabolism 10 Biliary secretion 10 Renal excretion 80 This drug has to be administered to A 65 years old patient Uttam Singh, with a GFR of 60mlmin.assuming normal GFR is 1w0mlmin. Liver and biliary functions and normal in the patient. What will be the dose rate of the drug X in this patient50mghr30mghr25mghr100mghr  <response>: Ref-Goodman and Gillman 12e p36-37 In this question 80 percent of drug is eliminated by renal route and 20percent by non-renal routes 10 percent by hepatic metabolism and 10 percent by biliary secretion . This patient has 50 percent renal function 60 ml min of GFR instead of 120 mlmin. Thus, the drug that can be eliminated in this person is 20percent Non-renal route 40 percent Renal route, 50 percent of 80 percent 60 percent Thus, the dose rate should be 60 percent of the original. i.e. 50 mghr x 60 percent 30 mghr. 