<prompt> Which of the following prokinetic drugs produces extrapyramidal side effects?MetoclopramideCisaprideDomperidoneAll of the above  <response>: Ref: KDT 6e p643, 644 Metoclopramide and domperidone act by blocking D2 receptors. Metoclopramide can cross BBB whereas domperidone cannot. Therefore, metoclopramide can produce extra-pyramidal adverse effects while domperidone is devoid of it. Cisapride acts as 5HT4 agonist. It can cause torsades de pointes. 