<prompt> Poorest prognosis in AML is seen in which cyiogcnetic abnormality-Monosomy 7No cytogenetic abnormalitytl5,i7inv, 16  <response>: Monosomy 7 or paial deletion of the long arm of chromosome 7 7q- is a frequent cytogenetic finding in the bone marrow of patients with myelodysplasia MDS and acute myelogenous leukemia AML Ref Davidson 23rd edition pg 789 