<prompt> Transfusion-Related Acute Lung Injury TRALI clinical symptoms are in force within how many hours after transfusion?48 Hrs72 Hrs6 Hrs12 Hrs  <response>: C 6 Hrs?Transfusion-Related Acute Lung Injury TRALI - Syndrome characterized by acute respiratory distress following transfusion.Clinical Symptoms:Clinically symptoms signs appear 1-2 hours after transfusion are in force within 6 hours.Typically are in force within 6 hours of transfusion.Rapid onset of dyspnea, fluid in the endotracheal tube, tachypnea severe hypoxia.Associated fever, cyanosis, hypotension.Clinical examination:Reveals Respiratory Distress.Pulmonary Crackles may be present with no signs of CHF or volume overload.During anaesthesia:A persistent decrease in blood oxygen saturation can be the presenting sign.CXR - Evidence of bilateral pulmonary edema unrelated to CHF Non-Cardiogenic Pulmonary edema.Bilateral patchy infiltrates rapidly progressing to complete white out indistinguishable from Acute Respiratory Distress Syndrome ARDS.Transfusion-Related Acute Lung Injury TRALI:Transfusion related noncardiogenic pulmonary edema.Differential diagnosis:Circulatory overload TACOAllergicAnaphylacticBacterialAcute hemolytic reactionTransfusion Related Acute Lung Injury TRALI:Life-threatening emergencyOccur during or up to 6 hours following transfusion.Incidence: 1:5,000-1:150,000Pathophysiology:HLA antibodies react with antigens on recipient granulocytes. Triggers an inflammatory response in the pulmonary vasculature.Non-cardiogenic pulmonary edema resulting from immune reactivity of certain leukocyte antibodies.Presentation:Pulmonary edema, trachypnea, tachycardia - Hypotension, frothy pink sputum andor fever.Treatment:There is no specific therapy.Stopping the transfusion.Instituting critical care supportive measures.Supportive monitor, airway, hemodynamicsNo LasixRemember:All blood components, especially FFP are implicated as causative factors.TRALI remains one of the top 3 most common causes of transfusion related deaths. 