<prompt> Which of the following is associated with PAS positive macrophages?Whipple diseaseAbetalipoproteinemiaCrohns diseaseUlcerative colitis  <response>: Ref. Robbins Pathology. 9th edition. Page. 791 Whipple disease:Rare systemic infection due to Tropheryma whippelii, a gram positive intracellular actinomyceteUsually affects proximal intestine, mesenteric lymph nodesAlso called intestinal lipodystrophy Symptoms:Malabsorption with diarrhea, weight loss, abdominal painOccasionally polyarthritis, CNS complaints, lymphadenopathy, hyperpigmentationCardiac involvement less common MicroscopyDistended macrophages in lamina propria containing PAS diastase resistant granules and rod shaped bacilli by EMDilated lymphatics or fat vacuoles 