<prompt> Apixaban is:Antithrombin inhibitorDirect Xa inhibitorPlatelet activatorClotting Factor XII  <response>: Ref. KDT. Page. 617Apixaban is an oral, direct, and highly selective factor Xa FXa inhibitor of both free and prothrombinase-bound FXa independently of antithrombin III for the prevention and treatment of thromboembolic diseasesApixaban prolongs clotting tests such as prothrombin time PT, INR, and activated partial thromboplastin time apttApixaban is absorbed in the stomach and small intestine87 plasma protein bound.Apixaban mainly undergoes o-demethylation and hydroxylation to metabolitesGrapefruit juice may increase apixaban serum concentration.St. Johns wort will likely decrease apixaban serum concentration 