<prompt> Lacunar cells are variants of Reed-Sternberg cells that are specifically found inLymphocyte-predominate Hodgkins diseaseLymphocyte-depleted Hodgkins diseaseMixed-cellularity Hodgkins diseaseNodular sclerosis Hodgkins disease  <response>: Hodgkins disease is broadly divided into four histologic subtypes, the most common of which is the nodular sclerosis variant. This type is characterized morphologically by the presence of the lacunar variant of Reed-Sternberg RS cells and by bands of fibrous tissue that divide the lymph node into nodules. Unlike the other subtypes of Hodgkins disease, it is more common in females. Young adults are classically affected and the disease typically involves the cervical, supraclavicular, or mediastinal lymph nodes. Involvement of extranodal lymphoid tissue is unusual. Variant RS cells with a multilobed, puffy nucleus popcorn cells are seen in the lymphocyte-predominant subtype. Reference: Robbins Cotran Pathologic Basis of Disease, 9edition. 