<prompt> Mikulicz cell Russell bodies are seen inRhinoscleromaRhinophymaRhinosporidiosisPlasma cel1 disorder  <response>: Refer: PL Dhingra, Textbook of Ear, Nose, Throat, 6thedition,pg no: 156Granulomatous disease of the nose BacterialFungalUnspecified causeRhinoscleroma Syphilis TuberculosisLupusLeprosy RhinosporidiosisAspergillosis Mucormycosis CandidiasisHistoplasmosis Blastomycosis Wegners granulomatosisNon-healing midline granuloma Sarcoidosis Churg Strauss syndrome Rhinoscleroma Agent - Klebsiella rhinoscleromatisSite - nose , nasopharynx, oropharynx, larynx, trachea, bronchi Atrophic stageFoul smelling purulent nasal dischargeGranulomatous stage Subdermal infiltration of lower pa of external nose upper lip - woody feelRubbery nodules - Tapir nose Cicatricial stage Stenosis of nares Distoion of upper lip Adhesions of nose, nasopharynx , oropharynx Subglottic stenosisNose deformity - Hebra nose Soft palate deformity - Gothic arch deformity Diagnosis Biopsy - infiltration of submucosa with plasma cells, lymphocytes, eosinophils, Mikulicz cells large foam cells with central nucleus vacuolated cytoplasm containing causative bacilli Russellbodieshomogenous eosinophilic inclusion bodies found in plasma cellsThe culture of the organism Treatment - Streptomycin 1gday tetracycline 2gday for 4 - 6 weeks 