<prompt> Chances of multiple sclerosis are maximum ifMother has the diseaseFather has the diseaseMother is carrierFather is carrier  <response>: . In multiple sclerosis genetic factors are also relevant ,the risk of familial recurrence in MS is 15,with highest risk in first degree relatives age adjusted risk:4-5 for siblings and 2-3 for parents or off spring . Ref Harrison20th edition pg 2456 