<prompt> All release histamine except ?PancuroniumD- TCSuccinylcholineMivacurium  <response>: Ans. is a i.e., Pancuronium Propeies of NM Blockers Longest acting Neuromuscular blocker - Pancuronium duration of action 120-180 minutes. Goodman Gilman 11 the p. 222 Note: In some books pipecuronium or Doxacurium have given as the longer activity. Shoest and fastest acting neuromuscular blocker - Succinylcholine suxamethonium - duration of action 5-8 minutes. Shoest acting competitive nondepolarizing neuromuscular blocker - Mivacurium duration of action 12-18 minutes. Fastest acting nondepolarizing blocker Rocuronium can be used for endotracheal intubation as an alternative to Sch. Non-depolarizing neuro-muscular blockers can cause ganglion block, vagal block and Histamine release different agents has different propensity. Histamine release is caused by - D-TC maximum tendency, succinylcholine, mivacurium, doxacurium, atracurium, tubocurarine - can cause bronchoconstriction. Viually no histamine release - Pancuronium Vagal block is caused by Pancuronium, recuronium, Gallamine. Maximal vagal block and tachycardia is caused by - Pancuronium Previously it was gallamine, but it is not used now. Vagal stimulation is caused by - succinylcholine can cause bradycardia. Ganglion block is caused by - d-Tc, Metocurine, Alcuronium. Maximum ganglion blockade is caused by - d-TC. Ganglion stimulation is caused by - Succinylcholine. 