<prompt> Neurofibrillary tangles and agarophilic plaque are character-istic feature ofAlzheimers dsCJDHepatic encephalopathyParkinsonism  <response>: Ans a: Ref: Harrison 17th ed pg 2541The area affected in Alzheimers ds are hippocampus temporal cortex and nucleus basalis of mayemet Microscopic finding are neurofibrillary tangles and senile neuritic plaques Neuritic plaque contain a central core that contain A? amyloid proteoglycans, apoE4, alpha 1 antichymotrypsin other proteinsAccumulation of A-beta amyloid on cerebral arterioles is amyloid angi-opathy.NFT- are silver staining, twisted neurofilaments in neuronal cytoplasm which represent abnormally phosphorylated tau protein 