<prompt> Select the false statement among the following?Lipid soluble drugs tend to have higher distributionVolume of distribution is reduced by high plasma protein bindingLoading dose is equal to Vd divided by target plasma concentrationT12 is constant in first order kinetics  <response>: Lipid soluble drugs nonpolar have high volumes of distribution than drugs which are more polar Volume of distribution may be increased in renal failure hepatic failure due to fluid retention, altered body fluid. However high plasma protein binding reduces the Vd. Loading dose volume of distribution x target plasma concentration Maintenance dose clearance x target plasma concentration T 12 is constant in first order kinetics T 12 is directly propoional to plasma concentration in zero order kinetics Clearance is indirectly propoional to plasma concentration 