<prompt> Primary component of nonadrenergic noncholinergic nerve transmission in gut is:VIP and NOVIP and CCKVIP and MotilinVIP and substance  <response>: Vasoactive intestinal peptide VIP It is usually produced by neurons It is a potent vasodilator, cause smooth muscle relaxation, increases blood flow and epithelial cell secretion It is the primary component of nonadrenergic noncholinergic neurotransmission in gut along with nitric oxide NO. Lack of VIP innervations plays a role in achalasia and Hirschsprung disease. Ref: Sleisenger and Fordtrans, Edition-9, Page-7. 