<prompt> A 30-year-old female complaints of fatigue and is unable to gain weight. On examination, her body felt warm. Which of the following investigation can be helpful in reaching the diagnosis?High TSH with normal T3, T4Low TSH with high T3, T4High TSH with euthyroid statusIncreased uptake of T3, decreased level of T4  <response>: On the basis of above clinical scenario patient is suffering fromprimary Hypehyroidism. Primary Hypehyroidism CLINICAL FEATURES: Sympathomimetic stimulation : Palpitations - beta1 activation Fine Tremors - beta 2 activation Sweat on palmssoles Hypeension - alpha1 activation 2. BMR -Weight loss 3. Calorigenesis - Heat intolerance 4. Females - Oligomenorrhea Infeility 5. Proptosis - Blinking action is inadequate - Drying of cornea - Exposure Keratitis - Grittiness sand like sensation in eye. Work-UP: Thyroid Function Tests - Total T4 T3- , Free T4, T3 - TSH: - If low - Primary hypehyroidism Fuher investigations are: LATS titre Thyroid scan USG Abdomen - If high - Secondary hypehyroidism - pituitary adenoma - Dx MRI head 