<prompt> Cofactor involved in metabolism of sulfur containing amino acids:BiotinVitamin B2Vitamin B1Vitamin B12  <response>: Methionine S-containing metabolism requires three vitamins :- Pyridoxine vitamin B6 Folate vitamin B9 Cobalamin vitamin B12. EXTRA EDGE: Defect in the metabolism of sulfur-containingaminoacids homocysteine due to the deficiency of cystathionine-b-synthase leads to homocystinuria and increases cardiovascular risk. Homocysteine is highly cytotoxic and elevated levels within the bloodstream are believed to damage the endothelial lining of aerial vessels,leading to intravascular coagulation. 