<prompt> Indicate the drug which does not improve lower esophageal sphincter tone or prevent gastroesophageal reflux, but is used as the first line treatment of gastroesophageal reflux disease :Sodium alginate aluminium hydroxide gelOmeprazoleMosaprideMetoclopramide  <response>: Increasing GI motility with prokinetic drugs like metoclopramide and mosapride orBy decreasing gastric acid secretion with PPIs like omeprazole. 