<prompt> Deficiency in globin synthesis -ThalassemiaSickle cell diseaseHereditary spherocytosissideroblastic anemia  <response>: Ans. is a i.e., Thalassemia Thalassemia Syndromeso The thalassemia syndromes are a heterogeneous group of disorders caused by inherited mutations that decrease the synthesis of either the a-globin or b-globin chains that compose adult hemoglobin, HbA a2b2, leading to anemia, tissue hypoxia, and red cell hemolysis related to the imbalance in globin chain synthesis.DisorderDefectThalassemiaDeficient Globin SynthesisHereditary SpherocytosisInherited red cell membrane defectSickle Cell DiseaseStructurally abnormal hemoglobin hemoglobinopathy 