<prompt> A diabetic patient with hypertension, which drug is preferred:ACE InhibitorBeta blockersCCBDiuretics  <response>: Ans. a ACE InhibitorRef Harrisons 18th ed. Ch 344 In a diabetic patient, hypertension can accelerate compli- cations of DM, particularly cardiovascular disease and nephropathy. In these patients ACE inhibitor is preferred. It slows down the progression of diabetic nephropathy. American Diabetic Association recommends that all patients with diabetes and hypertension be treated with an ACE inhibitor or an ARB. Subsequently, agents that reduce cardiovascular risk beta blockers, thiazide diuretics, and calcium channel blockers should be incorporated into the regimen. While ACE inhibitors and ARBs are likely equivalent in most patients with diabetes and renal disease, the ADA notes: In patients with type 1 diabetes, hypertension, and micro- or macroalbuminuria, an ACE inhibitor slowed progression of nephropathy An ACE inhibitor or an ARB slowed the progression to macroalbuminuria in patients with type 2 diabetes, hypertension, and microalbumin-uria; and ARB slowed the decline in GFR in patients with type 2 diabetes, hypertension, macroalbuminuria, and renal insufficiency. 