<prompt> What is DOC of Severe Complicated Falciparum Malaria is ?QuinineAemetherAesunateHydroxychloroquine  <response>: AEMESININS : Aemisinin and its three major semisynthetic derivatives in clinical use Dihydroaemisinin, Aemether and Aesunate are potent and Fast-acting Antimalarials. They are optimized for the treatment of Severe P. falciparum malaria and are also effective against the asexual erythrocytic stages of P.vivax. AESUNATE - All patients with Severe Falciparum Malaria should be treated with IV or IM Aesunate atleast 24 hours. The semisynthetic aemisinins have been formulated for Oral Dihydroaemisinin, Aesunate, and Aemether; Intramuscular Aesunate and Aemether; Intravenous Aesunate; and Rectal Aesunate routes. AEMETHER - is used only if Parenteral Aesunate is not available PROPEIES : Fastest acting Antimalarial drug Effective against MDR parasites Sho acting CI in 1st Trimester 