<prompt> Treatment of resistant depression is -ECTSSRITCAsVenalafexine  <response>: Ans. is a i.e., ECT Treatment of depression1 Drugs : - The treatment of major depression usually requires starting pharmacotherapy with antidepressants. Antidepressants are : -i Tricyclic antidepressants TCAs : - Imipramine, Amitriptyline, Trimipramine, Clomipramine, Desipramine, Nortriptyline, Amoxapine, Reboxetine.ii SSRI selective serotonin reuptake inhibitors : - Fluoxetine, Paroxetine, sertaline, Citalopram, Escitalopram. These drugs devoid of side effects seen with TCAs and are safe in elderly.iii Atypical antidepressants : - Trazodone, Mianserine, Mitrazapine, Venlafaxine, Duloxetine, Tianeptine, Amineptine, Bupropion.Not all patient recover completely after treatment; about 25 cases are refractory to treatment. Recurrence rate is 50 after 1st episode and 90after 3rd episode.2 ECT Electroconvulsive therapy : - Indications of ECT in depression are : -i Suicidal risk AIIMS 01,00, AI 94, MAHE 01ii Depression with psychotic featureiii Resistant depressioniv Severe agitated or stuporous depression with lack of self care.3 Psychotherapy : - Supportive psychotherapy, connitive behavioral psychotherapy. 