<prompt> Autosplenectomy is seen in:Hereditary spherocytosisSickle cell diseaseThalassaemiaAutoimmune anemia  <response>: - In sickle cell anemia initially, congestive splenomegaly is seen. - Later, sickled RBC causes aerial occlusion - ischemic damage to spleen - resulting in Fibrosis of spleen autosplenectomy. 