<prompt> Jarisch - Herxheimer reaction are seen in syphilis WithTetracyclinesPenicillinesCo-trimoxazoleSulfonamides  <response>: Penicillin 657-KDT 698-KDT 6thJerisch-Herxheimer reaction:- Penicillin injected in a syphilitic patient particularly secondary syphilis may produce shivering, fever myalgia, exacerbation of lesions, even vascular collapse. This is due to sudden release of spirochetal lytic products and lasts 12-72 hours. It does not recur and does not need interruption of therapy.Aspirin and sedation afford relief of symptoms. 