<prompt> Amyloidosis is most commonly seen inMaturity onset DMType1DMType2DMEqually seen with all forms of DM  <response>: Ref Robbins 8e p253; 9e p259 Amyloid replacement of islets is a characteristics finding in individual with long standing type 2 diabetes .it is believed that the islet amyloid protein is directly cytotoxic to isletsanalogous to the role played by amyloid plaques implicated in the pathogenesis of Alzheimers disease 