<prompt> Endogenous pyrogens act by ?Increasing heat generationRaising thermostat point of hypothalamusCausing vasoconstrictionBy Non-shivering thermogenesis  <response>: Ans. is b i.e., Raising thermostat point of hypothalamusBacterial toxins exogenous pyrogens stimulate inflammatory cells to secrete pyrogenic cytokines endogenous pyrogens, e.g. IL-I, TNF-a , and IL-6.These endogenous pyrogenes stimulate PGE2 release in hypothalamus, which raises temperature set point of hypothalamus to cause fever. 