<prompt> Which of the following is true about depression:Increased Serotonin and NorepinephrineIncreased serotonin decreased NorepinephrineDecreased serotonin and NorepinephrineDecreased serotonin increased Norepinephrine  <response>: Ans. c Decreased serotonin and NorepinephrineRef : Harrison 19th ed. 2714-2715 Depression is one of the mood disorders It is considered as most common psychiatric disorder. Most commonly seen in middle age females. M:F ratio 1:2 Neurotransmitters involved are serotonin and NE. Both are decreased.Diagnostic Criteria of DepressionMajor CriteriaMinor CriteriaPersistent sadness of moodLoss of appetiteLoss of pleasure in activitiesSleep disturbanceEasy fatiguabilityDecreased libido ConcentrationIdeas of guilt, worthlessness, hopelessnessSuicidal ideas.Depression Category on Basis of Severity Mild Depression :2 major 2 minor Moderate Depression :2 major 3 minor Severe Depression : 2 major 4 minorAlso KnowDiseaseRelated NeurotransmitterAlzheimers diseaseAcetyl cholineDepressionNorepinephrine, Serotonin 5-HT dopamine are DECREASEDOCNSerotonin 5 HTSchizophreniaDopamine, Serotonin Norepinephrine are INCREASED 