<prompt> Typical lesion in hard chancre is:Painless and induratedPainful and induratedPainless and non-induratedPainful and non-indurated  <response>: Ans: A Painless and induratedRef: Thappa DM. editor. Essentials in Dermatology, 2nd edn. New Del hi: JaypeeExplanation:Primary SyphilisPainless chancre Primary ChancreHunterian Chancre,Hard ChancreTypical chancre is round or oval ulcer, 1-2 cm across, has indurated margin, clear base and without any exudateModerate enlargement of inguinal lymph nodesNontender, nonsuppurative, firm, shottv Indolent buboRelapse of primary syphilis extremely rare Chancre ReduxSecondary SyphilisLesions are due to hematogeneous dissemination of treponomesFlu I ike symptoms - malaise, loss of appetite, fever, headache, stiff neck, myalgia and arthralgiaSkin manifestation are termed as Syphilids, are asymptomatic, polymorphous, variegate, bilateral and symmetricalEvanescent macular rash involving entire trunk, extremities and palms and solesPapular lesions demonstrate ollendor fsignEven nodules may appear: They may be pustular but never vesicularCondylomata lata: The moist, smooth surfaced warty intertriginous plaques Most Infectious LesionGeneralised lymphadenopathy: especially epitrochlear lymph nodesMoth eaten alopecia in scalpTertiary SyphilisGummatous: Non tender, pink to dusky red nodules or plaques that vary in sizeCardiovascular and neurosyphilis 