<prompt> Which of the following carries the least risk of Colonic malignancyFamilial adenomatous polyposisGardners syndromeVillous adenomaPeutz-Jeghers syndrome  <response>: PEUTZ-JEGHERS POLYPIt is common in the small intestine jejunum but can also occur in the large intestine.Features are multiple, familial, hamartomatous intestinal polyps.Associated with melanosis of the oral mucosa, lips lower lip and occasionally digits not in tongue.Microscopically it contains tree-like branching filaments of mucosa with smooth muscle wall.It can occasionally turn into malignancy. 