<prompt> Differences between fluconazole and ketoconazole areDuration of actionAbsorption dependency on gastric acidityAdverse effectsAll the above  <response>: Both are anti fungal drugs used to treat fungal diseases.Fluconazole is preferred to ketoconazole as it is long acting with less adverse effects.Flucanazole has wider spectrum,good oral absorption,less protein binding,less sideeffects compared to ketoconazole which has many drug interactions. Ref: KD Tripathi 8th ed. 