<prompt> Infectious mononucleosis affects?B-cellsT-cellsNK cellsMacrophages  <response>: Ans. a B-cellsRef: Wintrobes 12thpg 1589-1593Pathogenesis of Infectious Mononucleosis: Caused by Ebstein Barr Virus EBV Q infectionEntry of EBV in the oral cavity QEBV initially infects oral epithelial cells a symptoms of pharyngitis. QIntracellular Q viral replication and cell lysis with release of new virionsVirus spreads to contiguous structures such as the salivary glands QEventual viremia infection of B lymphocytes Q in the peripheral blood entire lymphoreticular system, including liver spleen.DOWNY cells are atypical CD8 T lymphocytes that are characteristic of infectious mononucleosis QDOWNY cells exhibit both suppressor cytotoxic Q functions that develop in response to the infected B lymphocytes. 