<prompt> A 22-year-old woman from a large Italian family is screened for a familial blood disorder. The results of laboratory studies include a hemoglobin of 9.5 gdL and a smear displaying mild microcytosis, hypochromia, and a few target cells. Haemoglobin electrophoresis shows a mild increase in haemoglobin A2 7.5. What is the appropriate diagnosis?Anemia of chronic diseaseG6PD deficiencyHeterozygous b-thalassemiaHomozygous b-thalassemia  <response>: - Heterozygous b-thalassemia is associated with Microcytosis hypochromia; degree of microcytosis is dispropoionate to severity of anemia, which is generally mild. Target cells, basophilic stippling mild increase in hemoglobin A2 are present Most patients are asymptomatic. - Homozygous b-thalassemia is a more serious disease associated with high amounts of HbF 