<prompt> Mechanism of action of quinolones is?DNA gyrase inhibitorsBind to 30 s unitBind to bacterial cell membraneBind to tetrahydofolate reductase  <response>: ANSWER: A DNA gyrase inhibitorsREF: Goodman G ill man s 11th ed p. 722The quinolone antibiotics target bacterial DNA gyrase and topoisomerase IV. For many gram positive bacteria, topoisomerase IV is the primary target. For many gram-negative bacteria, DNA gyrase is the primary quinolone target. 