<prompt> A 40 year old male patient is hospitalised with huge splenomegaly, marked sternal tenderness, and a total leucocyte count of 85,000 per cubic millimetre with large percentage of myelocytes and meta myelocytes, which one of the following drugs is best indicated for his disease ?CyclophosphamideChlorambucilMelphationHydroxyurea  <response>: Chronic phase of CML begins as a proliferative disorder consists of excessive proliferation of myeloid cells of intermediate grademyelocytes metamyelocytes mature segmented neutrophils.Drugs used in chronic phase of CML include imatinib,dasatinib, nilotinib, or classical cytotoxic drugs such as hydroxycarbamidehydroxyurea or interferon. Reference:Davidsons principles practice of medicine 22nd edition pg no 1039. 