<prompt> Most common cause of umblicus does not separate at age of 2 years.Raspbery tumourLeukocyte adhesion deficiencyPatent urachusUmbilici granuloma  <response>: Leukocyte adhesion deficiency 1289- B L 24th 61-62-Basis pathology 7th 985-Baily Love 25th Leukocyte adhesion deficiency LAD-1- Defects in b chain of CD 11 CD 18 integrins- Characterised by recurrent bacterial infections and impaired wound healing Leukocyte adhesion deficiency LAD-2- Defect in fucosyl transferase required for synthesis of sialylated oligosaccharide- Characterised by recurrent bacterial infections Raspberry tumour - Umbilical adenoma - due to a partially occasionally completely unobliterated vitellointestinal duct. Mucosa prolapsing through the umbilicus gives rise to a raspberry like tumour, which is moist and tends to bleed - Treatment umbilectomy 