<prompt> Which of the following is a histological feature of Whipples disease?Infiltration of histiocytes in the lamina propriaGranuloma in the laminaMacrophages with PAS material inside the lamina propriaEosinophils in the lamina propria  <response>: Whipples disease Hallmark - Presence of PAS ve, diastase resistant granules inside foamy macrophages containing rod shaped bacilli. The presence of T. Whipplei outside macrophages is more impoant indicator of active disease than their presence inside the macrophages. Multisystem involvement: Joints Early involvement Intestine - Impaired lymphatic drainage resulting in malabsorption diarrhea Lymph nodes CNS Late involvement Rx - Antibiotics 