<prompt> True regarding primary sclerosing cholangitis associated with ulcerative colitis are all of the following exceptBiliary cirrhosis is a known complicationIncreased risk of hilar cholangiocarcinomaMay have raised levels of alkaline phosphatasePrimary sclerosing cholangitis resolves after total colectomy  <response>: Patients with PSC and UC typically have a more quiescent disease course The risk for colon cancer in these patients is up to five times greater than in patients with ulcerative colitis alone. These tumors are more likely to arise proximal to the splenic flexure PSC is progressive and ultimately fatal unless liver transplantation is undeaken. Colectomy has no effect on the course of PSC Ref: Sabiston 20th edition Pgno :1508-1509 