<prompt> Following monoclonal antibody is directed against alpha 4 integrin REPEATEfalizumabNatalizumabIbalizumabToclizumab  <response>: Natalizumab is anti-integrin monoclonal antibody used in ulcerative colitis, Crohn;s disease and multiple sclerosis.Ref: Katzung 13th ed.pg 962. 