<prompt> True regarding Kaposis sarcoma is all exceptMay occur even in the presence of a normal CD4 T cell countHHV8 has been strongly implicated as a cofactor in the pathogenesisKoebners Phenomenon may be seenLymph node involvement suggests worst prognosis  <response>: In contrast to most malignancies, in which lymph node involvement implies metastatic spread and a poor prognosis, lymph node involvement may be seen very early in KS and is of no special clinical significance. Kaposi sarcoma causes lesions to grow in the skin, lymph nodes, internal organs and mucous membranes lining the mouth, nose and throat. It often affects people with immune deficiencies, such as HIV or AIDS. Ref Robbins 9e pg 234 