<prompt> Which of the following is true about anaphylaxis: September 2007It is mediated by allergen specific IgEType-I hypersensitivity reactionCytokines like IL4, IL5 and IL6 along with histamine is releasedAll of the above  <response>: Ans. D: All of the above Anaphylaxis is an acute multi-system severe type I hypersensitivity reaction. Based on the pathophysiology, anaphylaxis can be divided into true anaphylaxis and pseudo-anaphylaxis or anaphylactoid reaction. The symptoms, treatment, and risk of death are the same; however, true anaphylaxis is caused by degranulation of mast cells or basophils mediated by immunoglobulin E IgE, and pseudo-anaphylaxis occurs without IgE mediation 