<prompt> Which of the following statements is true about presynaptic inhibition?It results due to failure of the action potential to reach the synapseIt occurs due to hyperpolarisation of presynaptic membraneIt occurs due to inhibition of release of neurotransmitter from presynaptic terminalIt occurs due to blockade of neurotransmitter receptors  <response>: presynaptic inhibition into two categories: 1 inhibition mediated by axo-axonic or dendro-axonic projections i.e., a third pay interferes with the transmission of synaptic responses between a synaptically coupled pair of two neurons, which we may describe as heterosynaptic inhibition; and 2 inhibition mediated by the release of neurotransmitter from the active presynaptic terminal itself, or autoreceptive inhibition Ref: guyton and hall textbook of medical physiology 12 edition page number:546,547,548 