<prompt> Eye of the Tiger appearance in MRI is seen inWilsons diseaseNeuronal accumulation of ironAlzheimersHallervorden-Spatz syndrome  <response>: D Hallervorden-Spatz syndrome Eye of the Tiger Sign refers to abnormal low T2 signal due to abnormal accumulation of iron on MRI in the globus pallidus with a longitudinal stripe of high signal due to gliosis spongiosis that can be seen in: Hallervorden-Spatz syndrome: Classical but not 100 pathognomonic. Progressive supranuclear palsy Early-onset levodopa-responsive parkinsonism Corticobasal ganglionic degeneration 