<prompt> Osteoporosis is a major adverse effect caused by the glucocorticoids. It is due to their ability toLippincotts 3rd pharmacologyIncreases the excretion of calciumInhibit absorption of calciumStimulate the hypothalamic - pituitary adrenal axisDecreases production of prostaglandins  <response>: B. i.e. Inhibit absorption of calcium 314- Lippincotts 3rdGlucocorticoid- induced osteoporosis is attributed to inhibition of calcium absorption as well as bone formation.Increased intake of calcium plus vitamin D or calcitonin or of other drugs that are effective in this condition is indicated.Glucocorticoids suppress rather than stimulate the hypothalamic -pituitary- adrenal axis. The decreased production of prostaglandins does not play a role in bone formation. 