<prompt> Mutation in which of the following tumour suppressor gene causes carcinoma?p53p51RoAll of the above  <response>: If the p53 gene is mutated, the protection offered by the p53 tumor suppressor protein against DNA damage for example, ras oncogene mutation is lost. If a cell becomes homozygous for the mutant allele, that is loses heterozygosity, cancer may develop.Ref: Shafers textbook of oral pathology 7th edition page 108 