<prompt> The gaps between segments of DNA on the lagging strand produced by restricting enzymes are rejoinedsealed by:DNA LigasesDNA HelicaseDNA TopoisomeraseDNA phosphorylase  <response>: Ans. A. DNA LigasesThe fragments of newly synthesized DNA on the lagging strand are joinedsealed by DNA ligasesEnzymePrimary FunctionHelicaseUnwinds the DNA to provide single stranded DNATopoisomeraseRelieves torsional strain that results from helicase induced unwindingDNA primaseInitiates synthesis of RNA primersDNA polymerasePolymerizes dex nucleotides Polymerizes DNA Polymerase I: Gap filling synthesis of lagging strandPolymerase II: DNA proof reading and repairPolymerase III: Processive leading strand synthesis 5 - 3 directionDNA ligaseSeals the nicks between okazaki fragments on lagging strand. 