<prompt> Imatinib mesylate used in the treatment of GIST is a inhibitor ofIL-12TNF-xTyrosine kinaseVEGE  <response>: Imatinib mesylate used in the treatment of GIST GastroIntestinal Stromal Tumours is a c-kittransmembrane receptor tyrosine kinase tyrosine kinase inhibitor. GIST is rare but most common nonepithelial small bowel tumours. More than 95 show c-kit mutation. Reference : page 877 SRBs manual of surgery 5th edition 