<prompt> Women undergoing infertility treatment are advised to avoid NSAIDs in preovulatory period becauseProstaglandins contribute to ovulationNSAIDs inhibit LH surgeNSAIDs cause premature rupture of follicleNSAIDs like aspirin cause endometrial shedding.  <response>: Prostaglandin stimulates smooth muscle contraction in ovary, contributing to ovulation. prostaglandin synthetase inhibitors if taken in pre ovulatory period can cause luteinized unruptured follicle syndrome LUFS. 