<prompt> Drug s used in the treatment of multiple myeloma isare-BoezomibMethotrexateHydroxyureaKetoconazole  <response>: Drugs used as first line treatment of multiple myeloma include boezomibproteasome inhibitor thalidomide anti- angiogenic effects against tumour blood vessels immunomodulatory effects.Reference :Davidsons principles practice of medicine 22nd edition pg no 1047. 