<prompt> Atherosclerosis is associated with:LysineHistidineHomocysteineLeucine  <response>: HOMOCYSTINURIA - HOMOCYSTEINE ACCUMULATION LEAD TO STROKE, ATHEROSCLEROSIS, MI, PULMONARY EMBOLISM Accumulation of derived amino acid Homocysteine, results due to deficiency of Cystathionine Synthase and Cystathionase as shown in figure below. CF: -MENTAL RETARDATION -ECTOPIA LENTIS -SEIZURES -OSTEOPOROSIS MARFANOID HABITUS -SIMILAR TO MARFAN SYNDROME EXCEPT IN MARFAN LENS IS OUTWARDS AND UPWARDS IN HOMOCYTINURIA - LENS IS DOWNWARDS AND INWARDS HOMOCYSTEINE ACCUMULATION OCCURS IN CASE OF B6, B9 B12 DEFICIENCY 