<prompt> Which of the following is a suicidal enzymeCyclooxygenaseLipooxygenase5-nucleotidaseThrombaxane synthase  <response>: Cyclooxygenase is a Suicide EnzymeSwitching off of prostaglandin activity is paly achieved by a remarkable propey of cyclooxygenase--that of self-catalyzed destruction; that is, it is a suicide enzyme. Fuhermore, the inactivation of prostaglandins by 15-hydroxyprostaglandin dehydrogenase is rapid. Blocking the action of this enzyme with sulfasalazine or indomethacin can prolong the half-life of prostaglandins in the body.Ref: Harper;s Biochemistry; 30th edition; Chapter 23; Biosynthesis of Fatty Acids Eicosanoids 