<prompt> Lymphohistiocytic variant of Reed Sternberg cells are typically seen in which of the following variants of Hodgkin;s Lymphoma:Nodular SclerosisLymphocyte RichLymphocyte PredominantLymphocyte Depleted  <response>: Lymphocytic and histiocytic L and H variant of Hodgkin;s Lymphoma is typical of Lymphocytic Predominant Hodgkin;s Lymphoma. True diagnostic Reed-Sternberg cells are not seen. The neoplastic cells resemble ;popcorn; by viue of their folded or lobated nuclear nuclear membranes nuclei resemble an exploded kernel of corn. Note that cells resembling the Lymphohistiocytic or popcorn cell variants of Lymphocyte Predominant Non-classical Hodgkin;s Lymphoma may also be seen in Lymphocyte Rich Variant of Classical Hodgkin;s Lymphoma. These if present can be differentiated by Immunophenotyping: Lymphocytic and Histiocytic L H or ;popcorn; cells are typical of Lymphocytic Predominant Non-Classical Hodgkin;s Lymphoma. These cells are negative for CD15 and CD30 and positive for CD45. Cells resembling Lymphocytic and Histiocytic L H or ;popcorn; may be seen in Lymphocyte Rich form of classical Hodgkin;s Lymphoma. These cells are positive for CD15 and CD30 and Negative for CD45. Ref: Bailey and Love 27th edition 