<prompt> In Kidney which of the following is true?Osmolarity of tubular fluid in PCT gradually increasesOsmolarity of fluid in DCT is more than in Bowmanns capsuleFluid coming out of descending limb of loop of Henle is hypotonicOsmolarity of medullary interstitium is more than plasma  <response>: Ans. isdi.e., Osmolarity of medullary interstitium is more than plasmaRef: Guyton 12e p. 334The renal medulla shows an increasing osmotic pressure with increasing depth.Staing, with an osmolarity of 300 mOsmL in the coex, the osmolarity reaches a level of 1200-1400 mosmL at the pelvic tip of the medulla, i.e., The inner pa of medulla has highest osmotic gradient.That means that the renal medullary interstitium has accumulated solute in greater excess of water. 