<prompt> Regarding leflunomide in pregnancy all are true exceptCause hydrocephalus and skeletal anomalies in fetusPyrimidine synthesis inhibitorIts active metabolite can be detected in plasma for upto 2 years after dis continuationUsed to treat Rheumatoid arthritis in pregnancy  <response>: Leflunomide, is used to treat Rheumatoid arthritis, but is contraindicated in pregnancy. 