<prompt> A 30 year old lady presents to the outpatient depament with an Erythematous butterfly rash on her checks. Which of the following antibodies should be assayed initially for her suspected condition -Anti-Ds-DNAAnti-Ro-AntibodyAnti-Centromere-AntibodyAnti-mitochondrial-Antibody  <response>: Anti-dsDNA antibodies are a group of anti-nuclear antibodies ANA and their target antigen is double stranded DNA. Blood tests such as enzyme-linked immunosorbent assay ELISA and immunofluorescence are routinely performed to detect anti-dsDNA antibodies in diagnostic laboratories. They are highly diagnostic of systemic lupus erythematosus SLE and are implicated in the pathogenesis of lupus nephritis. 