<prompt> Breslow thickness is used inMelanomaSquamous cell carcinomaBasal cell carcinomaActinic keratosis  <response>: In melanoma, the probability of metastasis correlates with the depth of invasion, which by convention is the distance from the superficial epidermal granular cell layer to the deepest intradermal tumour cells; this measurement is known as the Breslow thickness.The probability of metastatic spread and prognosis, to predict an outcome is based on the following variables:1 tumour depth the Breslow thickness; 2 number of mitoses; 3 evidence of tumour regression presumably due to the host immune response; 4 ulceration of overlying skin; 5 the presence and number of tumour infiltrating lymphocytes; 6 gender; and 7 location central body or extremitySince most melanomas initially metastasize to regional lymph nodes, additional prognostic information may be obtained by performing a sentinel lymph node biopsyRobbins Pathology 9e pg: 1150 