<prompt> In Wegeners granulomatosis cytoplasmic anti neutrophilic antibodies are directed againstProteinase 1Proteinase 2Proteinase 3Proteinase 4  <response>: Wegener granulomatosis is a necrotizing vasculitis characterized by a specific triad of findings: Granulomas of the lung andor the upper respiratory tract ear, nose, sinuses, throat Vasculitis of small to medium-sized vessels capillaries, venules, aerioles, and aeries, most prominently in the lungs and upper respiratory tract Glomerulonephritis PR3-ANCAs are present in almost 95 of cases and probably drive the subsequent tissue injury; they also are useful markers of disease activity. Robbins basic pathology,9th edition.pg no.353 