<prompt> Most common site of carcinoma esophagus is:Middle 13rdUpper 13rdLower 13rdLower end of esophagus  <response>: Answer is C Lower 13rd The lower third of the esophagus is the most common site of esophageal cancer and accounts for about 50 of all esophageal cancers. About 15 of esophageal cancers occur in the upper third of esophagus cervical esophagus, 35 in the middle third of esophagus and 50 in the lower third - Harrison 16th524 Site of esophageal cancer All histological types of total Upper 13 15 Middle 13rd 35 Lower 13d 50 Note: The most common site of squamous cell histological subtype is middle 13 of esophagus The most common site of adenocarcinoma histological subtype is lower 13rd of esophaguse. 