<prompt> Which of the following is a poor prognostic factor in Acute Myeloid Leukemia AMLMonosomyDeletion of X or Y chromosomet 8; 21 translocationNucleophosphin mutation  <response>: Answer is A Monosomy Monosomy is consistently associated with an unorable or poor prognosis. Monosomy is associated with a poor prognosis Monosomy especially those involving chromosome 7 monosomy 7 and chromosome 5 monosomy 5 are consistently associated with poor prognosis in both adults and children with AML Deletion of X or Y chromosome is associated with a orable intermediate prognosis Monosomy of the X chromosome in a female patient loss of the Y chromosome is the most common whole chromosome loss identified in pediatric patients with AML. This numeric abnormality is usually associated with t8; 21 translocation and AML M2 which carry a good prognosis - Childhood Leukemias by Puri 2d253 Loss of Y and X chromosomes are most frequently observed in patients with t8; 21 which carries a ourable prognosis - Blood: Principles and Practice of Hematology 2d108 Nucleophosphin mutation is associated with a orable prognosis Factor Favourable Unourable Nucleophosphin mutation Present Absent t 8; 21 translocation is associated with a orable prognosis Factor Favourable Unourable Cytogenetics t15;17, 18;21, inv16 -7, del7q, -5, del5q, 3q21 and 3q26 abnormalities, complex karyotypes Prognostic Feature in Acute Myeloid Leukemia: Factor Favourable Unourable Clinical Age 45 yr 2yr, 60yr ECOG performance status 0-1 I Leukemia De novo Antecedent hematologic disorder, myelodysplasia, myeloproliferative disorder Infection Absent Present Prior chemotherapy No Yes Leukocytosis 25,000mm3 100,000mm2 Serum LDH Normal Elevated Extramedullary disease Absent Present CNS disease Absent Present Cytoreduction Rapid Delayed Morphology Auer rods Present Absent Eosinophils Present Absent Megaloblastic erythroids Absent Present Dysplastic megakaryocytes Absent Present FAB type M2, M3, M4 MO, M6, M7 Surfaceenzyme markers Myeloid CD34-, CDI4-, CD13- CD34 HLA-DR Negative Positive TdT Absent Present Lymphoid Cd2 CD7, CD56 Biphenotypic 2 or more lymphoid markers Present MDR-1 Absent Cytogenetics Cytogenetics 115;17, 18;21, inv16 -7, del7q, -5, del5q, 3q21 and 3q26 abnormalities, complex karyotypes Molecular markers Fms-related tyrosine kinase-3 mutation Absent Present Ecotropic viral integration site 1 expression Absent Present Mixed-lineage leukemia paial tandem duplication Absent Present Nucleophosphin mutation Present Absent CCAATenhancer-binding protein- a mutation Present Absent Brain and acute leukemia cytoplasmic gene expression Absent Present Vascular endothelial growth factor expression Absent Present 