<prompt> Patient who is on indinavir treatment presented with jaundice. On detailed evaluation is is found that the elevated bilirubin is mainly indirect fraction. The probable mechanism of indirect hyperbilirubinemia in this setting would be:Increased bilirubin productionDecreased hepatocellular uptakeDecreased conjugationHemolysis  <response>: Unconjugated Hyperbilirubinemia Increased bilirubin production Eg: hemolysis, ineffective erythropoiesis, blood transfusion, resorption of hematomas Decreased hepatocellular uptake eg: drugs such as rifampin, Gilbes syndrome Decreased conjugation Eg:Gilbes syndrome, Crigler-Najjar syndrome, physiologic jaundice of the newborn, drugs such as indinavir, atazanavir Ref:Sleisenger and Fordtrans,E-9,P-325 