<prompt> Drug of choice for Chronic Myeloid Leukaemia isHydroxyureaImatinibInfliximabIFN beta  <response>: B Imatinib TRASTUZUMABMechanismMonoclonal antibody against HER-2 erb-B2. Helps kill breast cancer cells that over express HER-2, possibly through antibody-dependent cytotoxicity.Clinical useMetastatic breast cancerToxicityCardiotoxicityIMATINIBMechanismMonoclonal antibody against the Philadelphia chromosome brc-abl tyrosine kinaseClinical useCML, Gl stromal tumorsToxicityCardiotoxicityVINCRISTINE, VINBLASTINEMechanismM-phase-specific alkaloids that bind to tubulin and block polymerization of microtubules so that mitotic spindle cannot formClinical usePart of the MOPP Oncovin regimen for lymphoma, Wilms tumor, ChoriocarcinomaToxicityVincristine-neurotoxicity areflexia, peripheral neuritis, paralytic ileus. Vinblastine blasts bone marrow suppressionPACLITAXEL, OTHER TOXOIDSMechanismM-phase-specific agents that bind to tubulin and hyper stabilize polymerized microtubules so that mitotic spindle cannot break down anaphase cannot break down anaphase cannot occurClinical useOvarian and breast carcinomaToxicityMyelosuppression and hypersensitivity 