<prompt> Acquired mutations in PIGA gene gives rise to:Paroxysmal Nocturnal HemoglobinuriaHereditary SpherocytosisIsoimmune hemolytic anemiaFanconis anemia  <response>: Paroxysmal nocturnal hemoglobinuria PNH is a hemolytic anemia that stems from acquired mutations in PIGA, a gene required for the synthesis of phosphatidylinositol glycan PIG, which serves as a membrane anchor for many proteins. Because PIGA is X-linked, normal cells have only one active PIGA gene, a mutation of which is sufficient to cause PIGA deficiency.Robins Textbook of pathology 10th ed Page 450 