<prompt> Earliest sign of systemic absorption of local anaesthetic isConvulsionsCirculatory collapseCircumoral numbnessRespiratory arrest  <response>: Manifestations of local anesthetic toxicity including lidocaine bupivacaineEarly symptoms Prodrome Circumoral numbness, dizziness, tongue paresthesia, restlessness, tinnitus, agitation.CNS symptoms :- These are biphasic i.e. excitation convulsions, restlessness, agitation tinnitus, followed by depression drowsiness, disorientation, respiratory depression, unconsciousness.Cardiovascular manifestations :- hypotension, cardiac arrest, coma. 