<prompt> Heart failure cells are -Lipofuscin granules in cardiac cellsPigmented alveolar macrophagesPigmented pancreatic acinar cellsPigment cells seen in liver  <response>: Heart failure cells siderophages are hemosiderin containing macrophages in alveoli that are seen in left ventricular failure and denote previous episodes of pulmonary edema.Left-sided heart failureThe major morphological and clinical effects of LVF are due to increased back pressure in the pulmonary circulation and the consequences of diminished peripheral blood pressure and flow,The extracardiac organs involved commonly are -1. Lung most common2. Kidney3. BrainLungThe pressure in the pulmonary veins increases and transmitted retrogradely to capillaries and arteries,This results in pulmonary congestion and pulmonary-oedema Wet lung.There is perivascular and interstitial translate, particularly in the interlobular septa responsible for Kerleys B lines on X-rays.Edematous fluid accumulates in alveoli.Iron-containing proteins and hemoglobin leak out from the capillaries and are phagocytosed by macrophages and converted to hemosiderin.Hemosiderin - containing macrophages in the alveoli called siderophages, or heart failure cells denote previous episodes of pulmonary edema.The clinical manifestations of LVF are primarily due to these changes in lungs Dyspnea, orthopnea, paroxysmal nocturnal dyspnea.KidneyDecreased cardiac output causes a reduction in renal perfusion.If it is severe enough to impair the excretion of nitrogenous product BUN, Creatinine, Prerenal ARF Prerenal azotemia may be precipitated.BrainReduced perfusion to the brain may cause hypoxicischemic encephalopathy. 