<prompt> Which of the following drugs for chronic hepatits B therapy is not given orally?LamivudineAdefovirTelbivudinePegylated interferon  <response>: Ans. is d i.e., Pegylated interferon The drugs which are used for the management of chronic hepatitis B infection include: Laivudine Adefovir Telbivudine Tenofovir Entecavir Pegylated interferonFollowing table illustrates the route of administration, duration of therapy and tolerability of each:FeasturePEG IFNLamivudineAdefovirEntecavirTelbivudineTenofovirRoute of administrationSubcutaneous InjectionOralOralOralOralOralDuration of therapy Tolerability48-52 weeks Poorly tolerated52 weeks Well tolerated48 weeks Well tolerated; creatinine monitoring recommended48 weeks Well tolerated52 weeks Weil tolerated48 weeks Well tolerated creatinine monitoring recommended Only pegylated interferon is given via subcutaneous injections and rest others are given via oral route of administration. 