<prompt> All of the following statements about Guillain -- Barre Syndrome are true, ExceptInflammatoryDemyelinatingDescendingCranial Nerve Involvement  <response>: Answer is C Descending: Guillain Barre Syndrome is typically an ascending not descending neuropathy. Guinan Barre Syndrome is typically an acute inflammatory demyelinating polvneuropathy. The usually pattern is an ascending paralysis and cranial nerve involvement is common. The typicalmost common variant of GBS is Acute Inflammatory Demyelinating Polyneuropathy AIDP. Diagnostic Features of Acute Inflammatory Demyelinating Polyneuropathy AIDP I. Required for Diagnosis 1. Progressive weakness of variable degree from mild paresis to complete paralysis 2. Generalized hyporeflexia or areflexiae II. Suppoive of Diagnosis 1. Clinical Features a Symptom progression: Motor weakness rapidly progresses initially but ceases by 4 weeks. Nadir attained by 2 weeks in 50, 3 weeks 80, and 90 by 4 weeks. b Demonstration of relative limb symmetry regarding paresis. c Mild to moderate sensory signs. d Frequent cranial nerve involvement: Facial cranial nerve VII 50 and typically bilateral but asymmetric; occasional involvement of cranial nerves XII, X, and occasionally III, IV, and VI as well as Xl. e Recovery typically begins 2-4 weeks following plateau phase. 0 Autonomic dysfunction can include tachycardia, other an-hythmias, postural hypotension, hypeension, other vasomotor symptoms. g A preceding gastrointestinal illness e.g., diarrhea or upper respiratory tract infection is common. 2. Cerebrospinal Fluid Features Suppoing Diagnosis a. Elevated or serial elevation of CSF protein. b. CSF cell counts are 10 mononuclear cellmm. 3. Electrodiagnostic Medicine Findings Suppoive of Diagnosis a 80 of patients have evidence of NCV slowingconduction block at some time during disease process. b Patchy reduction in NCV attaining values less than 60 of normal. c Distal motor latency increase may reach 3 times normal values. d F-waves indicate proximal NCV slowing. e About 15-20 of patients have normal NCV findings. f No abnormalities on nerve conduction studies may be seen for several weeks. III. Findings Reducing Possibility of Diagnosis 1. Asymmetric weakness 2. Failure of bowelbladder symptoms to resolve 3. Severe bowelbladder dysfunction at initiation of disease 4. Greater than 50 mononuclear cellsmm3 in CSF 5. Well-demarcated sensory level IV. Exclusionary Criteria 1. Diagnosis of other causes of acute neuromuscular weakness e.g., myasthenia gravis, botulism, poliomyelitis, toxic neuropathy. 3. Abnormal CSF cytology suggesting carcinomatous invasion of the nerve roots NCV, nerve conduction velocity. 