<prompt> End diastolic voIume increases in:Decrease in total blood volumeIncrease in intrapericardial pressureIncrease in negative intrathoracic pressureDecrease in ventricular compliance  <response>: Ans. c. Increase in negative intrathoracic pressure Ref: Ganong 23e p515End diastolic volume increases in conditions associated with increase in negative intrathoracic pressure.Factors Affecting End Diastolic VolumeFactors Decreasing EDVFactors Increasing EDV Increased intra-pericardial pressureQ as a result of infection of pressure from a tumor:- Limits the extent to which ventricle can fill Decrease in ventricular complianceQ:- Increase in ventricular stiffness produced by Ml, infiltrative disease. Standing decreases venous returnQ Increased total blood volume increases venous returnQ: Constriction of vein reduces the size of venous reservoir, decreasing venous pooling and thus increasing venous return Increased negative intrathoracic pressureQ: Increases the pressure gradient along which blood flows to the heart Muscle activityQ: Increases venous return as a result of pumping action 