<prompt> Classical hemophilia of due to the absence ofSmall pa of factor VIIILarge pa of factor VIIISmall pa of factor IXLarge pa of factor IX  <response>: Plasma factor VIII-vWF complex is made up of two proteins. One, which is required for the activator of factor X in the intrinsic coagulation pathway, is called factor VIII procoagulant protein, or factor VIII.Deficiency of factor VIII gives rise to haemophilia A. factor VIII is associated noncovalently with a much larger protein, vWF, that forms high - molecular-weight multimers of sizes that range as high as 20 megadaltons.vWF is found normally in the plasma in association with factor VIII, in platelet granules, in endothelial cells in unusual cytoplasmic vesicles called Weibel-palade bodies, and in the subendothelium, where it binds to collagen. 