<prompt> A patient with Hepatitis C, exhibits hypo-complimentemia with 2 gmday protein uria and hematuria. The most probable diagnosis isMPGNCryoglobulinemiaMembranous glomerulopathyPost-infectious glomerulonephritis  <response>: Ans. a. MPGN Type I MPGN is c.ommonly associated with persistent hepatitis C infections, autoimmune diseases like lupus or cryoglobulinemia, or neoplastic diseases.- Harrison 18e p2344 So, in the above mentioned patient with Hepatitis C, exhibits hypo-complimentemia with 2 gmday proteinuria and hematuria. The most probable diagnosis is MPGN Membranoproliferative Glomerulonephritis MPGN is sometimes called mesangiocapillary glomerulonephritis or lobar glomerulonephritis. It is an immune-mediated glomerulonephritis characterized by thickening of the GBM with mesangioproliferative changes; 70 of patients have hypocomplementemiaQ. MPGN is subdivided pathologically into type I, type II, and type III disease. Type I MPGN is commonly associated with persistent hepatitis C. infectionsQ, autoimmune diseases like lupus or cryoglobulinemiaQ, or neoplastic diseases Types II and HI MPGN are usually idiopathic, except in patients with complement factor H deficiency, in presence of C3 nephritic factor andor in paial lipodystrophy producing type II disease, or complement receptor deficiency in type III disease. Membranoproliferative Glomerulonephritis Type I MPGN Most Common Idiopathic SABEQ SLEQ Hepatitis CQ - cryoglobulinemia Mixed cryoglobulinemia Hepatitis bQ Cancer: Lung, breast and ovary germinal Type li MPGNDense Deposit Disease Idiopathic C3, nephritic factorassociatedQ Type Ill MPGN Idiopathic Complement receptor deficiencyQ 