<prompt> A patient presented with diminished vision and neuropsychiatric manifestations and with hepatic dysfunction. His eyes on general examination and slit lamp examination appeared as shown in the Figure below. What investigation you will do next?Serum ceruloplasmin level24 hr Urine copper levelMRI brainHaplotyping  <response>: Ref. API Textbook of Medicine. Pg. 870 Image represents Kayser-Fleischer ring - KF ring is golden brown ring due to deposition of copper in Descements membrane of cornea. Wilsons Disease:Rare autosomal recessive disease.Characterized by abnormal copper metabolismSternliebs criteria:Presence of KF ringsDecreased serum ceruloplasmin copper containing enzyme ferroxidase levelsMeasuring hepatic copper levels in liver biopsy24-Hr urine copper excretion Kayser Fleischer ring:Excess circulating copper deposits in descemets membrane.Usually golden brown located in peripheral cornea, beginning at schwalbes line upto 5 mm into cornea.Detected via Gonioscopy in earlier stage seen by naked eyes in advanced stage. 