<prompt> Cytokines are secreted in sepsis and Systemic Inflammatory Response syndrome SIRS by -NeutrophilsAdrenalPlateletsCollecting duct  <response>: Cytokine release in Sepsis The mechanism by which endotoxin causes activation of inflammatory cells and release of cytokines has already been explained earlier.It is by TL -4 and CD-14 mediated.Signals from TLR-4 can directly activate vascular endotheliun and leukocytes to release cytokine mediators.The major cells that secrete cytokines in sepsis areaMonocyteMacrophages Neutrophils Endothelial cellsCytokine mediators involved are:-TNF - The most important cytokine in sepsis IL-1 IL-6 IL-8 NO. 