<prompt> A 40 year old woman is on treatment for CLL. Over the past few months she noticed swellings in the neck and axilla which was rapidly increasing in size. She complains of feeling feverish and experiences weight loss. Which of the following is responsible?Richter transformationProgression of CLLDevelopment of secondary infectionsImmunodeficiency associated hemolytic anemia  <response>: CLL: Chronic Lymphocytic leukemia CLL:- Neoplastic proliferation of native B cell; . Transformation to diffuse large B cell Lymphoma is marked by enlarging lymph node or spleen and worsening of symptom. This phenomenon is called Ritcher Transformation. Dx by flow cytometry positive for CD1920, CD 523 Tx: Fludarabine is Drug of choice for management. 