<prompt> Hereditary spherocytosis is due to deficiency -SpectrinInvertinCytokeratinAll of the above  <response>: Hereditary spherocytosis HSHereditary spherocytosis is an inherited disorder, caused by intrinsic defects in the red cell membrane that is characterized by the production of red cell that is sphere-shaped rather than a biconcave doughnut-shaped, and therefore are sequestrated in spleen and destroyed there.A structural defect in Hereditary spherocytosisMembrane-cytoskeleton that lies closely opposed to the internal surface of the plasma membrane, is responsible for elasticity and maintenance of RBC shape.Membrane skeleton consists :Spectrin The chief protein component.Ankyrin and band 4.2 Binds spectrin to band 3Band 3 A transmembrane ion transport protein.Band 4.1 Binds spectrin to glycophorin A, a transmembrane protein.Hereditary spherocytosis is caused by a variety of molecular defects in genes that code for any of the following:-Ankyrin Most commonBand 3 Second most commonSpectrin CIBand 4.2Hereditary spherocytosis is acquired as autosomal dominant in the majority of the cases. In some cases, the autosomal recessive pattern of inheritance is seen. 