<prompt> A 24 year old unmarried woman has multiple nodular, cystic, pustular and comadonic lesions on face, upper back and shoulders for 2 years. The drug of choice for her treatment would beAcitretinIsotretinoinDoxycyclineAzithromycin  <response>: The DOC for nodulocystic acne is oral isotretinoin 13-Cis Retinoic acidIndications of isotretinoin Severe acne 25 lesions, Nodulocystic lesions, Large nodular lesions, Moderate acne not responding to oral antibiotics Recalcitrant acne. 