<prompt> All of the following statements about hormone replacement therapy H are true except ?It increases the risk of coronary aery diseaseIt increases bone mineral densityIt increases the risk of breast cancerIt increases the risk of endometrial cancer.  <response>: Ans. is d i.e., It increases the risk of endometrial carcinoma Hormone replacement therapy increases the risk of MI coronary aery disease. The increased risk is attributed to progestin component. o H restore Ca balance, fuher bone loss is prevented and the excess fracture risk is nullified. o There is a higher incidence of breast cancer. o Risk for endometrial carcinoma is not increased as protective effect of progestin nullify the carcinogenic effect of estrogen. o There is increased risk for gall stone and migraine. o There is a small protective effective of H on colorectal cancer. Note :? o Usually in H combination of estrogen and progestin is given combined H, except in hysterectimized women where estrogen alone is given. o With estrogen alone there is increased risk of endometrial cancer and decrease risk of coronary aery disease as estrogen increases HDL and decreases LDL and triglyceride level. o So for H with estrogen alone the answer of this question will change. In that case it will be option a i.e., increased risk of coronary aery disease. 