<prompt> Autosplenectomy is seen in?Hereditary spherocytosisG6 PD deficiencySickle cell anemiaThalassemia major  <response>: ANSWER: C Sickle cell anemiaREF: Harrisons Internal Medicine 17th edition Chapter 60. Enlargement of Lymph Nodes and Spleen, CMDT 2009 chapter 13 Blood Disorders AnemiasPatients with sickle cell disease often suffer from autosplenectomy as a result of splenic destruction by the numerous infarcts associated with sickle cell crises during childhood.Indeed, the presence of a palpable spleen in a patient with sickle cell disease after age 5 suggests a coexisting hemoglobinopathy, e.g., thalassemia or hemoglobin C 