<prompt> Alpha 1 antitrypsin deficiency seen in -EmphysemaBronchitisARDSBronchieactasis  <response>: Ans. is a i.e., Emphysema o a1-anti-trvpsin deficiency :-o a1-anti-trypsin deficiency, is an autosomal recessive disease marked by abnormaliy low levels of serum of this major protease inhibitor Pi o Deficiency of the enzyme leads to pulmonary emphysema panacinaro Liver is characterised byPresence of round to oval cytoplasmic globular inclusions in hepatocytes which on H and E stains acidophilic and indistinctly demarcated from surrounding cytoplasm.They are PAS positive and diastase resistantIn most part, only distinctive feature is globules infrequentlv-fatty change, mallory bodies.Neonatal hepatitis with cholestasisFatty change steatosisCirrhosis may develop which can transform into hepfocellular carcinoma. 