<prompt> The following statement is not true about the use of clonidine in the treatment of hypertensionReduction in central sympathetic outflowIncrease in LDL-cholesterol on prolonged useSedation and xerostomia are common side effectsIt can be combined with vasodialators  <response>: Ans. is b i.e. Increase in LDL-cholesterol on prolonged use Clonidine is a selective cc2 receptor agonist. It can act on peripheral oc2 receptors also but its major hemodynamic effects result from action on central sites primarily in medulla Vasomotor centreIt stimulates a2 receptors present mainly post junctionally at these sites central - decrease in sympathetic outflow - fall in B.P. and bradycardia.So it is used as an antihypertensiveDecreased sympathetic outflow to kidney results in reduced renin release so it can be combined with other antihypertensives which increase plasma renin activity such asDiureticsVasodilatorsCCBsACE inhibitorsClonidine has no effect on plasma lipid levelAdverse effectssedationmental depressiondryness of mouth xerostomia nose and eyesconstipationimpotency 