<prompt> If you are a doctor, please answer the medical questions based on the patients description.Hi Doctor, I have diagnosed with iga nephropathy now i am having methylprednisolone 48mgday since 24th Sep. But two days ago i have got a severe knee pain in the middle of the night it was terrible. Kindly advise why this has happened is it becoz of the pred? Also my legs face got swollen as well. B Rgds, Lalindra.  <response>: Hi there, IgA nephropathy is associated with protein leak in urine. If protein leak is too much or associated with increase salt and water intake it can lead to rapid increase in swelling. Also if patient develops kidney dysfunction with rise in serum creatinine levels it can lead to decrease in urine and sudden increase in swelling. IGA nephropathy can be associated with HSP, a condition which can have progressive disease with knee pain. Paient on steroids can develop infection which may present with knee pain. All these possibilities are there but a good examination by nephrologist and investigations will give the answer. Contact your doctor as soon as possible 