<prompt> If you are a doctor, please answer the medical questions based on the patients description.im 36 years old and ny wife 26 years, im married since 4 years but still there is no pregnancy, i make all the test before pregnancy HySTEROSALPHINGOGRAM-normal, hormonal profile- my wife have elevated TSH- subclinical hypothyrodism- she take thyroxin 75mcg and the hormone level is normal, semen analysis is normal, IUI done one time but failed. just i want to ask about failure IUI and i dont get pregnancy till now and possible solutions thanks  <response>: Hello Dear. In Infertile couple usually 25 defect in male.25 defect in female, 25 defect in both male female, 25 defect still not known .my advice to do sexual contact in mid-cycle for example - 28 days menstrual mid-cycle will be 14 days 3 days before 3 days after mid-cycle. GUI will be solution but some time fail due to technical reason. Also advice to do YOGA RELAXING exercise. Wish you good health. 