<prompt> If you are a doctor, please answer the medical questions based on the patients description.what is the difference between a staph infection and MRSA? My husband was told he has a staph infection. Its on his penis. Is it possible for him to get a staph infection on his penis without some sort of contact? I was out of town when he got it.  <response>: Thanks for contacting ChatDoctorYou are curious what the difference is between MRSA and staph infection. Your husband was diagnosed with a staph infection on his penis recently. Staph is a bacterium that is on everyones skin. The staph only becomes a problem with open skin from trauma or abrasion that gets into the deeper layers of skin and starts an infection. MRSA is a specific type of staph infection where it is resistant to most antibiotics. We do have antibiotics for MRSA, but it can be more difficult to cure. If your husband has a regular staph infection he should have received antibiotics, and he should complete the course of medication. Hope I answered your question. Please contact us again with your medical questions or concerns 