<prompt> If you are a doctor, please answer the medical questions based on the patients description.I need to know if Single Umbilical Artery is related to x-linked icthyosis. I have three children, two boys with the disorder. My sister is 4 12 months pregnant and recent ultrasound said that she only had one artery in her umbilical cord  <response>: Hits quite common to have fears if any of family member suffering with congenital disorders.I can understand your tension. Single umbilical artery is usually associated with cardiac, renal, skeletal and intestinal problems in baby. There is no studied data regarding association of ichthyosis with it. As for I know its not related. Nothing to worry. Go for anomalous scan at 22wks.Its important to evaluate for heart, kidneys, bones intestines. Thank youth best regardsVasundhara 