<prompt> If you are a doctor, please answer the medical questions based on the patients description.I was diagnosed with Parkinson s7 years ago and up until recentlyMirapex sinemet mostly took care of walking problem, I have recently had 2 major back surgeries and my mobility deteriorated even after going through rehab physical therapy. My neurologist has prescribed Comtan3 X daily. My sinemet went from 2 X daily to 4 X daily. My mirapex remains same at 4 X daily My question is do I take the Comtan at same time as sinemet or does it matter how I take it?Thank you.  <response>: Hi, There are no serious interactions that may result in adverse effects between Com tan Entacapone, Mir apex Pramipexole and Sine met CarcinomaLevodopa. Com tan should be taken with every dose of Sine met simultaneously. So, I think you should discuss with your Neurologist for changes in the schedule of taking Sine met and Com tan. Hope I have answered your query. Let me know if I can assist you further. 