<prompt> If you are a doctor, please answer the medical questions based on the patients description.Respectable Dr. Very recently after my check up doctor advised me to take Istamet 50 mg 500 Mg morining and evening.Just want to make sure, there is any side effect from this medicine.Many thanks for your valuable information With best regards XXX YYYYYY  <response>: Hi, I can understand your concern regarding safety of the prescribed medication. Stamen is a combination of two medicines sitagliptin 50 mg and Metformin 500 mg commonly prescribed to treat type 2 diabetes mellitus. Generally it is well tolerated by most of our patients, however it may cause stomach upset, vomiting, diarrhea, cramps, hypoglycemia low blood sugar and rarely a serious condition called lactic acidosis. Continue taking it as prescribed and report any side effects. Hope I have answered your query. Let me know if I can assist you further. 