<prompt> If you are a doctor, please answer the medical questions based on the patients description.If a paitent experiences an allergic reaction to IV Cleo and is treated with benadryl and Tylenol and the IV site cannot be changed; how long should further antibiotic treatment be held given that the antibiotic is DCd and replaced with another? Should we wait for the half-life of benadryl to pass so as to not cover symptoms of a second allergy the patient was unaware of the original allergy. Are there any published resources regarding this?  <response>: Cellophane You for contacting Chat Doctor. Whenever there is allergic reaction to Chat Doctor. Reaction usually gets limited within few hours. After 4-6 hrs antibiotic can be given BUT same antibiotic group is avoided. Patients are in that case given alternativesecond class antibiotic for treatment. I would suggest to wait for at least 6 hrs and then start further medication. Hope this answers your question. If you have additional questions or follow-up questions then please do not hesitate in writing to us. Wishing you good health. 