<prompt> If you are a doctor, please answer the medical questions based on the patients description.My daughter had hard spots on her meaty part of her palm near her wrist . And complained of itchiness. The hard spots are gone. But now she has blister like bumps in the middle of her palm which is very itchy for her. I just lathered on some hydrocortisone Creme 1. To calm it down. Could this be an allergy of some sort or beginning sign of eczema?  <response>: Hello, Reading your query, irritant contact dermatitis is a likely possibility if this is restricted to both hands and wrists. Patch tests usually read at 48 hours and 72 hours to a variety of chemicals or if there is a clear trigger like rubber can be done by Dermatologists and the trigger may be identified. Low potent steroids with antihistamines are useful, but stronger steroids can be used if required. I hope this was useful. 