<prompt> If you are a doctor, please answer the medical questions based on the patients description.I have a hard knot on my right shoulder kind of above the collarbone in the muscle area. It s been there for around 3 months and recently has started giving me pain. The pain is in the general area and now has started going up the right side of my neck. I am worried because cancer does run in my mother s side of the family. Should I be concerned.  <response>: Hi, Dear,Good afternoon. Thanks for the query to my Chat Doctor online-clinic. I studied your query in-depth.-In my opinion the painful hard knot above collar bone for last 3mths is mostly due to the Necrotic Hopkins or TB lymphadenitis or due to infectious mono or due to Lyme disease with lymphadenitis -Cause of lump-Could be fixed by the MRI FNAC Biopsy of the hard lump-as you have family history of Cancer.-Inflammatory infectious or cancerous-HL NHL-needs to be differentiated undercover of-ER Surgeon-as it concerns me due to your family history. Personally still I feel it to be of chronic infectious origin unless proved otherwise.-Hope this would resolve your worry-some query. Wellcome again to Chat Doctor. Have a good day. 