<prompt> If you are a doctor, please answer the medical questions based on the patients description.Hi I recently went to the ER for lower right side painpressure, fells like someone is pushing in on my lower right side. Ct scan shows retroperitaneal nodes and enlarged spleen with thick loop SB. Blood work normal. What would you think it could be. ER doc mentioned lymphoma?  <response>: HI, thanks for using Chat Doctor There are different possible causes for enlargement of the spleen such as: 1 infections2blood disorders such as leukemia, lymphoma, platelet disorders3tumors and cysts in the spleen4autoimmune disease5liver disease can lead to enlarged spleen6heart failureYour doctor would likely consider further testing including blood tests. The treatment would depend on the findings. I hope this helps 