<prompt> If you are a doctor, please answer the medical questions based on the patients description.Hi my wife is 50 year old and diagnosed HCV positive GENO TYPE 3.and infected chronically trough blood transfusion 23 years ago. She was treated for 6 months with Pegylated interferon Ribavarin. Virus disappeared during the treatment bur reappeared within 1 month after stopping treatment .The liver is showing moderate hepatomegaly and fatty changes.What is the current line of treatment, we can give?  <response>: Hi, Welcome to Chat Doctor. I understand your concern about HCV infection, but unfortunately HCV infection of genotype 3 is most resistant to treatment with bad prognosis. Newer Chat Doctor. The effectiveness of the treatment depends on the following factors:1. Age of patient2. Presence of cirrhosis3. Viral load of HCV. I suggest you discuss with her treating doctor combination therapy of regulated interferon and Bavaria with increased dose as that is the best therapy for genotype 3 HCV keeping the above-mentioned criteria in mind. Thanks. 