<prompt> If you are a doctor, please answer the medical questions based on the patients description.Hello Sir.. I am just passed mbbs and now working as medical officer in sub district hospital.. My sister s husband having fever since 2-3 days .. it reaches 102.5F .. cbs is normal with only thrombocytopenia 1,20,000 and malaria negative, dengue and lepto antigen negative and widal with o titre 1: 20 and H 1:40 at first week .. After taking my senior opinion I am started treatment with Magnazone inj. cefperazone and salbactam and now today with ofloxacin as signs and symtoms resemble typhoid .. But after 2 dose of inj. ofloxacin , his fever still comes and reaches to 102.3 F max.. I want to know how may days required to subside fever in typhoid with ofloxacin treatment ?  <response>: HelloWelcome to Chat Doctor Nice to have a question from our community. Single ofloxacin treatment is not sufficient according to me. We are practicing some another regimen with very good results with very low relapse rate. Definite 200 mg 1 tab twice a dayAzithromycin 500 mg 1 tab for 5 days with pantoprazole 40 mg 1 tab twice a day. All for two weeks. You can also use combination of definiteofloxacin for 14 days. Azithromycin is used for relapse prevention. Hope you will get it. Thanks for contacting. 