<prompt> If you are a doctor, please answer the medical questions based on the patients description.I have been taken Zeffix for more than five year. Last PCR done in Germany show zero value with very small signals. I still take Zeffiex for more that 12 months after last metioned PCR. my wife also has Hepatitus b but she didnt take Zeffix. And we had sex this month.My Question is I should stop zeffix. And do I need to repeat PCR after stopping several times.Thanks  <response>: Hi, Welcome to Chat Doctor. I understand that you have to repeat PCR frequently, but it is necessary, and it will indicate the viral load of hepatitis B which will denote your response to Suffix. Zeffix is an antiviral lamivudine which is quite effective for Hepatitis B. If your spouse is also suffering from hepatitis B infection, she should also be treated as soon as possible as there are chances of her infecting you during intercourse. I suggest you get a PCR done now before stopping Suffix, if vital load is 20,000 IU, then you do not need to repeat it. I hope I have cleared your doubts. Thanks. 