<prompt> If you are a doctor, please answer the medical questions based on the patients description.I started Sinemet today for Parkinson s Disease 12 tab 3x s per day. I have my last dose at 8 pm, 12 hr. from now. I ve been reading side effects horror stories, have been med free for the last 2 yrs., as long as I know I have P.D.. Is it ok to skip the last dose occasionally? Thank You  <response>: I read your question carefully, and I understand your concern regarding side effects. It would have been useful if you had mentioned also the tablet dosage, there are different Sine met tablets with different concentration of its components, so hard to judge how high a dose is what you have been prescribed. Sine met is not a curing Chat Doctor. So not taking it wont have any effect on disease progression, it is safe. You wont have the desired effect though. Also skipping it doesnt mean you wont have side effects after the other two dosages if you have any side effects at all. So I wouldnt skip this dose, only if you experience side effects can you lower the dose, but not by skipping one dose but by taking say 14 tablet 3 times daily. I hope to have been of help. 