<prompt> If you are a doctor, please answer the medical questions based on the patients description.Diagnosed with m in 2010 and initially treated with Hormonal injections, anti-androgen tablets and bisphosphonate Lucrin, Androcur to Casodex, Zometa Radiotherapy in 2011 for ?Bony pain Started on Chemotherapy with Docetaxel Textotere 2013 Now rising PSA and evidence of disease progression on CT and Bone scan  <response>: Good Day, and thank you for being with Chat Doctor ! Yes a rising serum PSA is almost always considered as an evidence of cancer activity and progression. A rising PSA is considered as treatment failure. I hope I have succeeded in providing the information you were looking for. Please feel free to write back to me for any further clarifications at: .comdoctors Chat Doctor. Best wishes 