<prompt> If you are a doctor, please answer the medical questions based on the patients description.I have been taking the depo shot for about a year now. About 4 days after getting the shot I will get symptoms that mimic a yeast infection: white clumpy discharge, itching and burning. However, this isnt a yeast infection. About 1-5 of women suffer these side effects from the depo. My question is is there something I can do or a medication that I can take that will alleviate these symptoms? They will last a very long, excruciating few weeks.  <response>: HI, thanks for using Chat Doctor Some women are more prone to have yeast infections. The following may help: 1determine if there is underlying immune deficiency such as diabetes, steroids, other immune suppressing medications, HIV2 probiotics-these may help to reduce the frequency of acute infection3using cotton underwear, cool clothes4you may need a prolonged course of antifungals hope this helps 