<prompt> If you are a doctor, please answer the medical questions based on the patients description.Hello sir, my ESR is 120, CRP is 98 and HLA B27 is positive. So doc suggested me to take 1. Saaz 500 mg 2times a day, Naproxen 500mfg 2 times a day, Methotrexate 15mg once a week, folic acid 5mg once a week and depo-medrole inj 80mg once a week for 4weeks. I have been taking this course for more then 1 month but there is no relief from cronic pain in both knees, ankles of both legs and middle finger with heavy swelling. So plz suggest me what should I do. Thanks and regards - Sachin  <response>: From the test results that you have mentioned you have peripheral arthritis as seen in RA but the HLA b27 is typically positive in Ankylosing spondylitis. The 2 disease can occur together in a person but rarely. You have any other symptoms like urethritis, psoriasis,lower back pain?the treatment you are receiving it takes time to improve condition. Get your painful joints X-rays done. Keep taking the medicines and do not stop it in between. Visit a physiotherapist it will help as exercising is good,itll release the stiffness. You might have given next appointment in 2-3 months and would have advised to carry recent blood tests that are advice by your doctor. For this its always better to see a rheumatologist if you have not yet. 