<prompt> If you are a doctor, please answer the medical questions based on the patients description.Every morning when i wake up i have a painful erection. It slowly goes away after i urinate but sometimes that ishard to get started. Its been going on about a month. I have psoreatic arthritis in my knees and have been taking Humira. Could the Humira be causing it?  <response>: Hello, There is no such side effect of Humor causing such a symptom. If you are taking certain antidepressants, it can cause ED or painful erection. Sometimes, when there is UTI, it can cause painful erections. You are suggested to visit a GP, get physically examined. You will have to get Urinalysis RE CS done. Furthermore, you may have to get some blood tests done. If sexually active, get STD tests done. Get assessed treated at the earliest. Hope I have answered your query. Let me know if I can assist you further. Take care Chat Doctor. 