<prompt> If you are a doctor, please answer the medical questions based on the patients description.Hi,One of the glands at the base of my penisi think it is called the Cowper Gland is quite a bit larger than the other.There is no pain at all but it as not gone down at all since i first noticed it i am not sure if its always been as large or not..RegardsBrian  <response>: Hi, It is not that easy to identify swelling to be Cowpers gland. Yes, it can enlarge when there is obstruction infection. Doing an ultrasound scrotum can help diagnose the cause. To know the issue really with Cowpers gland - you wont be getting the pre-ejaculatory fluid before you ejaculate. Next time give a check before masturbation or sex. Hope I have answered your query. Let me know if I can assist you further. 