<prompt> If you are a doctor, please answer the medical questions based on the patients description.my brother s is a leukemia patient .he is 4 years and 2 months old . currently he is undergoing final mentainanace ttt with MTX and 6-MP . along with septran .his current SGPT is 77 UL while his SGOT is 48 UL please could you tell me if we should decrease his dosage of 6-MP ?  <response>: Hi, 6 MPMercaptopurine is stopped when total bilirubin levels are more than 2 mgd or GOT, SEPT 200. However, in patients of leukemia this is not the only criteria, we have to also look for absolute neutrophil count, and any associated complications like pancreatitis. If I was treating your brother, then I have kept these things in mind also. If only GOT and SGPT are in range of 70 to 80,then there is no need to decrease 6 MP. I hope this has helped you. Wishing your brother good health. 