<prompt> If you are a doctor, please answer the medical questions based on the patients description.I am 50 yrs old have been taking zoloft and estrogen replacement. I have gained 30 pounds and am a small person. My stomach is so bloated I look pregnant. I do not eat junk food or soda. I eat chicken, fish, vegs and salads...I am at my wits end. I suffer from panic attacks so going off the meds is not an option. I am also extremely tired all of the time and have no energy to excersice. Any advice what be welcomed  <response>: Hi. Thanks for your query. The reasons of your symptoms of bloating, tiredness and no energy to exercise can be due to the following factors:-Estrogen replacement can be the first reason itself as it alters the bodies physiology.-Also has direct effect on Psychology and so on. It is possible that you may need to get altered dosage after talking to your Doctor.-Zoloft- Sertraline also has side effects of weight gain as this is amitriptyline group, and you seriously need to talk to your treating Doctors.-Local causes can be intestinal disturbed flora which can be easily corrected by taking pre and probiotics. -Or if possible you should take another second opinion of a doctor to have detailed sessions of psychotherapy and change of medicines. -Get some tests :Hormonal levels, thyroid functions, blood sugar, Electrolytes. 