<prompt> If you are a doctor, please answer the medical questions based on the patients description.I use to take an extremely high dose of Oxycodone...was taking for 11 years...dosage was increased over and over and over...by the time I finally insisted that my pain mgmt doctor put me in the hospital and rapid detox me, my daily dose was up to 720mg a day all prescribed!...that was 4 years ago! I was never a mental addict of this drug...I quit when I couldn t stand my life being robbed any longer, and except for the physical withdrawl symptoms, I have never, ever desired to take it again. My question is: why has my physiology changed? I need to have both shoulders replaced, but when I tried to have the first surgery, they started my on 5mg of Lortab a day for three days leading up to the surgery...my body went crazy? Immediatly I was already reverting back to wanting the dose I was taking when I quit at 720mg a day! There is no way I could ever have gone through with the surgery...they would never have been able to control my pain. Will my physiology ever change back...or will I just have to accept at 58 I ll have to live in this much pain for what s left of my life? God help me if I ever have an accident or get cancer...again!!  <response>: Hello, The physiology usually changes back. Furthermore, having a feeling of wanting more may be a psychological expectation AND, MOST IMPORTANTLY, it is usually NOT associated with tolerance to high doses of narcotics. It is the usual situation that someone who expects to need a previously sky-high dose and that is the highest Ive ever heard of and Im an addiction doctor! will die from a fatal overdose when they go back to their previous dose. Hope I have answered your query. Let me know if I can assist you further. Take care Chat Doctor. 