<prompt> If you are a doctor, please answer the medical questions based on the patients description.I am Male and my blood group is Ove. I intend to get married to a lady having blood group O-ve. Can there be some blood group incompatibility issues during child birth or after the 1st child? Can the new borns suffer from any kind of disease, including Thalassemia. Is there something like 1st child will be fine and the subsequent ones will have problems? What is RHRF not sure factor? I heard some kind of injections are given to mother to resolve such blood group incompatibility issues with the fetus during pregnancy, what are the side effects on mother due to such injections? Is blood grouptype checking of would be bride and groom necessary for any reason apart from possibility of having HIV virus?  <response>: Hello welcome to Chat Doctor sir, Incompatibility in the newborn fetus may cause HDNBhemolytic disease of newborndepending upon the severity of red cell breakdown.this is because of Rh antibodies developed in the motherif mother is Rh -ve because of either previous blood transfusion or birth to a baby who is Rhve.1. If the above said antibodies develop before the 1st childbirththat means if blood transfusion done.,then 1st baby will affect.2. If the above said antibodies develop after the birth of 1st childbirth your 1st baby will be normal.and for second pregnancy these antibodies travel across placenta and make red cell to break in the baby. Rh means rhesus factor... Rh ve means presence of Rh antigen in the blood.né negative means absent. Regarding your query.you are Ove and your would be is O-ve. If she had prior blood transfusion that too receives ve blood.then you need to take anti D injection.nowadays that ve blood is not giving to -ve one in the fear of future problems. After the 1st pregnancy your wife had to receive anti D immunoglobulin to suppress her immune status because of babies blood.after taking of this anti D then further pregnancies would be normal.no problem will arise. Incompatibility doesnt cause thalassemia,it is an inborn genetic error in the red blood cells. There is no side effects to that injection. Before marriage checking for HIV status is mandatory,..other else not necessary and not required.hope you understand my answer and suggestion. Thank you Chat Doctor. 