<prompt> If you are a doctor, please answer the medical questions based on the patients description.what is the best treatment for seasonal variation in mooddepression?  <response>: Hello. Seasonal Affective Disorder can be treated with the usual anti-depressants that are used for other depressive disorders. Where the usual anti-depressants dont work, thyroid hormones are also known to help. Photo-therapy light therapy is also known to be effective, especially with winter onset depression. Psychotherapy can help improve the depression in the long run. A combination of these methods is usually employed, based on a persons symptoms. The treatment is usually customized for the individual needs. Hope this helps. Abhijeet Deshmukh, MD 