<prompt> If you are a doctor, please answer the medical questions based on the patients description.Dear sir my mother is 65 , she is suffring from knee pain owing to which doctor has prescribed vitamin D pills bone lift , oral injction , lornoxicam tablets , she is also taking dibeties tab, high blood pressure treatment and niksm tablet for gestro issue , but since a week she has severe issue of appetite and constipation and kidny stone ,, kindly suggest that what should I do  <response>: With such presentations in my clinic, I would first rule out renal hypertension with renal testsurea, creatinine, uric acid because of history of Diabetes and Nephrolithiasis. For hypertension I suggest-Atorvastatin 1 tablet daily at night for 2-3 month.-TelstraTelmisartan 1 tablet at night for a long time. For knee ain I would suggest a pain relieving medicine like Fetoprotein 75 mg orally 3 times a day or 50 mg orally 4 times a day. if not allergic to for 5 days, Antigen plus 1 castle twice a day for 1 month, then 1 capsule daily for 2 months. If it is not relieved I would refer to an Orthopedist for further management. With respect to your other medical conditions like Diabetes, high cholesterol and blood pressure, there is a high risk of heart disease in the future. This risk can be greatly reduced by keeping the blood pressure below 13085, any time blood glucose less than 140 mgDL, and LDL under 70 mgDL. Work with your primary care Doctor to achieve these. Please let me know if you have further questions before meeting your primary care Doctor. 