<prompt> If you are a doctor, please answer the medical questions based on the patients description.my husband has had a chronic skin rash for 8 months andnow ha pussy postules in the palm of his hands and his genitalia. very itchy all over body. has been to a dermatologist, but no help. he is a cll patient. can not figure what is causing the rash.60 years old.  <response>: Hello, Looks like secondary cutaneous changes, manifesting like purpura, vasculitis, exfoliating erythroderma, etc. Avoid taking purine analogs alkylating agents. Get a follow-up physical examination done by your treating doctor to rule out skin infiltration with beta lymphocyteMalignantnon-malignant disorder often seen in CLL patients. Your husbands treatment will depend upon the type of skin manifestation detected investigated. It can be harmlessinsect biteallergic rash but if detected malignant it will require immediate treatment without delay. Hope I have answered your query. Let me know if I can assist you further. Take care Chat Doctor. 