 period 1 - single AZD7986 25 mg on Day 1 1 hour before food, washout 7 days period 2 - verapamil 240 mg extended release formulation daily 1 hour before food Day 1 to 10 and a single dose of AZD7986 25 mg 1 hour before food Day 5, washout period 14 days period 3 - subject to interim pharmacokinetic analysis of AZD7986 alone compared with AZD7986 and verapamil combined, either itraconazole 200 mg, oral solution formulation 10mgmL administered twice on Day 1 and daily on days 2 to 11 1 hour before food plus AZD7986 25mg single dose on Day 6 1 hour before food; or diltiazem 360 mg, extended release formulation on Days 1 to 13 1 hour before food plus AZD7986 25 mg 1 hour before food on Day 8. 