 At screeningbaseline phase, investigators obtain informed consent form, check the inclusionexclusion criteria and then collect the following data: demographics, medical history data, vital signs, ECG, MRICTB-ultrasoundX-ray examinations, physical examination, laboratory examinations, pregnancy test only female and bone marrow biopsy and aspiration. Pathological diagnosis of mantle cell lymphoma should be established by lymph node biopsy or other tumor histopathological examination and immunophenotyping. At the same time, ECOG-performance status, FactGOG-Ntx questionnaire and NF-κB activity will be assessed. 