 - Patients with pre-existing anti-hypertension treatment with an ACE inhibitor or angiotensin receptor blocker ARB are to be excluded. Co-administration of ACE inhibitors, including COVERSYL, with other agents blocking the Renin-Angiotensin System RAS, such as ARBs or aliskiren-containing drugs, will not be allowed, since such treatment has been associated with an increased incidence of severe hypotension, renal failure, and hyperkalemia. 