 7 Power calculation and statistical analysis The interstudy variability of CMR for LV mass using a protocol similar to ours, has been reported between 2.8 to 4.8 with a SD of 8.4g23. To demonstrate a 10g improvement in LV mass in the active treatment group, the investigators would need 19 patients α 0.05 and Power95. Accounting for a dropout rate of 30, the investigators will recruit 25 patients in each group. Comparisons for continuous variables will be performed using independent sample t-test between the active treatment and placebo group. 