 - Inhaled Corticosteroid: A well-documented requirement for regular treatment with high-dose inhaled corticosteroid ICS in the 12 months prior to Visit 1 with or without maintenance oral corticosteroids OCS. For 18 years of age and older: ICS dose must be 880 microgram ugday fluticasone propionate FP ex-actuator or equivalent daily. For ICS Long-Acting Beta-2-Agonists LABA combination preparations, the highest approved maintenance dose in the local country will meet this ICS criterion. For subjects 12-17 years of age at Visit 1: ICS dose must be 440 ugday fluticasone propionate FP ex-actuator or equivalent daily, For ICSLABA combination preparations, the highest approved maintenance dose in the local country will meet this ICS criterion. 