 22. Subjects who in the investigators judgement are perceived as having an excessive risk of thromboembolism for example because of a personal history andor a first degree relative with a personal history with onset under the age of 55 of significant thromboembolism, including but not limited to deep vein thrombosis, pulmonary embolism, cortical sinus thrombosis, coronary and cerebrovascular events, and peripheral arterial insufficiency. 