 Radial artery spasm during cardiac catheterization is identified by pain in the forearm aggravated by movement of the cathetersheath; difficulty in manipulating the catheter; loss of radial pulse or damping of radial arterial pressure. Tortuosity and loops in upper extremity arterial tree could mimic some findings of radial artery spasm. Incidence of radial artery spasm has been reported to range between 4 and 20. Incidence of loss of radial pulse after transradial coronary angiography has been reported between 2.5 to 10. Risk factors for radial artery spasm include smaller radial artery diameter, atherosclerotic lesions, entrance of guidewires into side branches, vessel tortuosity, larger arterial sheath diameters, longer procedure duration, female sex, younger age, lower body mass index, diabetes mellitus, number of catheters used, volume of contrast medium used, unsuccessful access at first attempt, fear and anxiety. Use of parenteral cocktails with different combinations of heparin, nitroglycerine, verapamil, nitroprusside, nicorandil, diltiazem, lidocaine, molsidomine, magnesium sulphate and phentolamine have been studied to reduce radial artery spasm. 