 v Cardiac Tissue Doppler Imaging and Transthoracic Echocardiography: Cardiac TDI will be recorded for longitudinal deformation. Data will be obtained from septum, lateral, anterior and inferior wall using narrow sector typically 120. Longitudinal S and SR will be calculated over a computation area of 10 mm. SR and S averaged over 3 cardiac cycles will be analysed using dedicated software SPEQLE, Univ. Leuven figure 3. The intra- and inter- observer variability of this approach is less than 1022. 