 Immune reconstitution following allogeneic HSCT is an important research interest among Experimental Transplantation and Immunology Branch Investigators. Current evidence suggests a critical role for interleukin-7 IL-7 in CD4 T cell homeostasis, and interleukin-15 IL-15 appears crucial to CD8 T cell and NK cell homeostasis. The relationships between these cytokines and lymphocyte subpopulations have not been studied in the setting of allogeneic HSCT; such analysis may enhance our understanding of engraftment kinetics, graft-versus-host disease, and immune reconstitution. We will correlate serum IL-7 and IL-15 levels with changes in circulating T-cell and NK-cell subpopulations during EPOCH-FR induction chemotherapy, after transplantation, and with the development of GVHD. 