 During Cycle 1 only, you will also take rituximab by vein once a week for 4 weeks total of 4 doses. The first rituximab infusion by vein usually takes 6 to 8 hours. Later infusions are generally shorter, taking about 4 hours to complete. For participants who have a large mass or who have lymphoma cells in their blood, the rituximab dose may be split into a 2-day infusion. Vital signs temperature, blood pressure, respiration, and heart rate will be monitored just before, during, and after the infusions. There will be an observation period of about 1 hour after the end of each rituximab infusion, after which you will be allowed to go home. 