 The installation of the orthodontic appliances promotes an increase in the retentive area available for microbial aggregation, difficult the oral health promotion and, in addition, promotes the artificial selection of biofilms containing a higher load of pathogenic microorganisms. In this way, it becomes of critical importance, the development of techniques that might aid in the reduction of the oral microbial load. One possible approach is the use of the Antimicrobial Photodynamic Therapy APDT. In this direction, the objective of this study was to assess the clinical utility of the APDT and the association of the APDT with the SDS surfactant as oral decontamination agents in orthodontic patients. The selected patients n24 were randomly distributed within seven experimental groups: G1 - Negative control, G2 - Curcumin mouthwash, G3 - Curcumin mouthwashSDS, G4 - light irradiation, G5 - APDT, G6 - APDTSDS and G7 - Positive Control Chlorhexidine mouthwash. Nonstimulated saliva samples were collected from each one of the patients in three steps S, as follows: S1- Initial condition, S2 - Treatment with mouthwashes water, Chlorhexidine or Curcumin and S3 - After APDT treatment. The efficacy of the proposed treatment protocols was assessed in function of the survival fraction observed in each group. The obtained results were statistically analyzed using variance analysis ANOVA and the Kruskal-Wallis test. 