 Patients will be recruited from two health facilities Kibagabaga District Hospital, and Kinyinya Health Center in Kigali, Rwanda that offer care and treatment for HIVAIDS patients. Patients will be recruited during a 3-4 month period. Consenting adults who fit the inclusion criteria will be enrolled and followed for 2 years. Study assessments will occur at enrollment, 6, 12, 18, and 24 months after initiation of selenium supplementation. 