 The study will be a randomized, controlled, cross-over clinical trial of borage oil and soybean oil to determine whether the metabolism andor impact of MC-PUFAs in botanical oil supplements are changed in relationship to specific genotypes in a SNP rs174537 strongly associated with FADS1 activity and PUFA metabolism. Subjects previously genotyped at rs174537 will be given supplements and both blood PUFA serum and erythrocyte membranes, urinary eicosanoids and eicosanoid release from whole blood leukocyte generation will be measured as biochemical determinants of genotype impact on supplement metabolism. 