 1 diabetes also occurs in patients who do not gain weight;2 2 in many cases, improvement in diabetes occurred within 2 weeks, too fast for this to be an effect of a reversal in weight changes; and 3 the relatively high rate of ketoacidosis, as well as the rapidity of the recovery following the discontinuation of the treatment, suggests that the putative diabetogenic effects of the atypicals might be secondary to the inhibition of insulin secretion, rather than insulin resistance. Very little is known about the mechanisms of typical antipsychotics in obesity and overweight, however, there should be some shared pathways in both types of antipsychotics, and specific pathways used by only typicals or atypicals. 