 - At the time of randomization: Absolute neutrophil count ANC must be 1,200mm3; Platelet count must be 100,000mm3; There must be evidence of adequate hepatic function as follows: total bilirubin must be 1.5 x the upper limit of normal ULN for the lab; and alkaline phosphatase must be 2.5 x Upper Limit of Normal ULN for the lab; and the Aspartate Amino Transferase AST must be 2.5 x ULN for the lab; and If AST is ULN, serologic testing for Hepatitis B and C must be performed and results must be negative; Calculated creatinine clearance must be 50 mLmin. 