 Amylin is produced in the pancreas the part of the body that makes insulin by the same cells that produce insulin and is also lacking in persons with T1DM. Amylin works by lowering glucagon after a meal. This keeps the liver from letting out stored sugar into the blood stream right after we eat. Pramlintide is man-made amylin and is given as a subcutaneous shot under the skin similar to insulin. At present, pramlintide has not received FDA approval. 