 Classically, humans are infected by contaminated food minced meat undercooked products, unpasteurized milk and cheese..., by the animal environment especially cattle or by transmission from person to person. EHEC virulence is associated with the presence of toxins called Shigatoxins Stx and the presence of the eae gene, responsible for damage attachment - clearing in the colon and caecum. Two major types of Shigatoxin, Stx1 and Stx2, and many Stx1 or Stx2 variants were identified: three variants for Stx1 and at least, six variants for Stx2. The determination of different profiles variants Stx is considered as predictive of the severity of STEC infections with progression to HUS, especially Stx2d activated and Stx2c After ingestion of contaminated food, STEC are able to withstand the acidity of the stomach and colonize the digestive tract. Toxins produced by the bacteria go through the intestinal epithelium, join the circulatory system and reach their target organs, mainly kidneys and CNS. Indeed, toxins bind to a specific glycolipid receptor, globotriosylceramide Gb3 on the surface of endothelial cells of target organs digestive tract, kidney, CNS, pancreas driving on the one hand, the release of pro-inflammatory factors TNF- α, IL6, IL8 involved in the formation of lesions of microangiopathy and leading to apoptosis of the target cells Hurley et al. 2001 Thorpe et al, 1999 Zoja et al.2010. 