 Advances in conventional imaging abdominal ultrasound, CT scan, MRI are so great that chance to discover a incidental solid or cystic pancreatic lesion is becoming usual. Endocrine tumors have variable malignant potential depending on their size, some malignancy for lesions larger than 2 cm and indefinite for a smaller size. The branch-duct like IPMN intraductal papillary mucinous pancreatic tumor involving the pancreatic secondary ducts represent half of pancreatic cystic tumors and may degenerate into 5 to 10 of cases. Signs and risk of degeneration are the presence of mural nodules greater than 5 mm and size 3 cm, although the latter criterion is discussed. Mucinous cystadenomas could degenerate between 30 and 50 of cases even though the role of size is much discussed 4 cm. The follow-up imaging is performed using MRI and endoscopic ultrasonography EUS. A fine needle aspiration for cytology and histology is possible and determination of biological markers is useful. But cytology is often unprofitable due to the poor cellular profile of the cystic pancreatic tumor. Once the diagnosis of suspected malignancy, the patient should be referred to the surgeon for pancreatic resection more or less extensive. But this attitude is facing a significant operative risk with up to 30 of morbidity and mortality between 1 and 3 for cephalic resections. Some patients with high post operative risks are inoperable. For these reasons, some teams have proposed the destruction of the walls of the cyst under EUS, US or CT control by washing with absolute alcohol content of cystic tumor. 