 Prior studies have established that a two-stage, angled incision results in improved wound integrity with 23, 25, and 25 MIVS systems6,7, helping to prevent complications such as post-operative endophthalmitis and hypotony. However, in the two clinical series describing outcomes of 27 gauge MIVS, a one-stage, perpendicular wound construction was performed without complication in a series of 31 patients2,8. Thus far, direct comparison between wound construction techniques one-stage, perpendicular or two-stage, angled has not been evaluated. 