 Males and females Any ethnic origin Between 18 and 55 years of age Body mass index BMI between 18.0 and 32.0 kgm2 inclusive Body weight between 50 kg and 100 kg inclusive Subjects must be in good health, as determined by Medical history, Physical examination, Vital sign assessment, 12-lead electrocardiogram ECG, Clinical laboratory evaluations congenital non-haemolytic hyperbilirubinaemia is acceptable Subjects will have given their written informed consent to participate in the study and to abide by the study restrictions 