 Our hypothesis is that chronic antigen exposure during peanut oral immunotherapy OIT will induce beneficial changes in the specific immune response, including: 1 anergy of IgE effector immune cells e.g., mast cells, basophils resulting in clinical desensitization; 2 induction of de novo, long lived memory B cell responses that antagonize specific IgE and confer immune tolerance. The investigators will test this hypothesis in the following specific aims: 