 OUTLINE: This is a randomized, open-label, multicenter study. Patients are stratified according to LDH levels no greater than upper limit of normal ULN vs greater than ULN, initial bulky disease yes vs no, stage I or II vs II or IV, ECOG performance status 0 or 1 vs 2 or 3, and participating center. Patients are randomized to 1 of 2 treatment arms as follows: 