 I. To determine the dose-limiting toxicity DLT rate in cycle 1 in each of three uridine diphosphate UDP glucuronosyltransferase 1 family, polypeptide A1 UGT1A1 genotype groups 11, 128, 2828 using genotype-guided dosing of irinotecan irinotecan hydrochloride as part of the FOLFIRABRAX regimen. 