 100 patients undergoing solid cancer surgeries will be recruited for perioperative CTCDTCcfDNA isolation from the blood, urine and bone marrow with innovative techniques. In addition, 10 patients undergoing similar surgeries for benign disease will also be included as controls. CTCsDTCs, cfDNA and cancer tissue pheno- andor genotype analysis will be performed with different innovative techniques. Furthermore, CTCsDTCs will be enriched, cultured and characterized. Tumor growth potential will be studied in nude mice. 