 8. Adequate hepatic function: total bilirubin upper limit of normal ULN, serum albumin 3.0 gdL, alanine aminotransferase ALT and aspartate aminotransferase AST 1.5 × ULN. ALT andor AST may be 5 × ULN if due to liver metastases. If ALT or AST is 1.5 and 5 × ULN in patients with liver metastases, alkaline phosphatase must be 2.5 × ULN. Patients with Gilberts syndrome are allowed if total bilirubin is 2 × ULN and direct bilirubin is ULN. 