 - 200 patients will be included in each group, with a total of 400 patients in the study. This is based on the following: We expect a MACE rate of 25 in the control group and 13 in the interventional group. With an alfa of 5 and a strength of 80, 167 patients will be needed in each group two-sided chi square test to demonstrate this difference. By including 200 patients in each group, a possible dropout before follow-up is counted for. 