 If the interaction of these three elements the host genetics - environmental factors - and intestinal microbiota metabolic choline has an influence on the severity of the lesions of NAFLD and ALD direct application may be of bring a food supplement choline in patients at risk mutation of the PEMT gene phosphatidylethanolamine N-methyltransferase, postmenopausal women, microbiota profile for increased degradation of dietary choline to restore the amount of choline in the body and thus to avoid a worsening of the ALD or NAFLD and progression to cirrhosis. 