 A better understanding of the nature and correlates of diabetic complications is crucial in the fields ongoing efforts in improving the care and welfare of schizophrenic patients. In addition, diabetes and X-syndrome associated with antipsychotics andor schizophrenia also may represent a unique opportunity for understanding the pathogenesis and management of diabetes in general. It also could be potentially a particularly effective model for studying gene-environment interactions that are crucial for understanding most common human diseases. Ultimately, our goal is to develop genetic tests to predict therapeutic responses. As such, from the view of a national health economy, this study may prove that personalized medicine saves money. 