 Coronary artery disease CAD is the leading cause of death among adult population in developed countries. Optimal method of revascularization of patients with multivessel CAD is still the matter of debate. Currently, there are two recognized methods: percutaneous coronary intervention PCI and coronary artery bypass grafting CABG. Both methods were compared in a number of studies, including several randomized trials. Most trials have left some doubts. First of all, none of them used functional evaluation of the stenosis. The decision regarding revascularization was based on angiographic results alone. The trials that have used fractional flow reserve FFR show no clear correlation between the degree of stenosis assessed angiographically, in the range of 50-90, and its functional significance. In a randomized FAME trial, out of 1329 significant stenosis assessed anatomically, nearly 40 revealed no functional significance. The study showed that coronary revascularization guided by FFR in multivessel stable CAD resulted in a smaller number of vessels stented, and hence fewer stent implantations. Such a strategy has improved patient clinical outcomes. In the group of patients undergoing revascularization based on fractional flow reserve significant reduction in major adverse cardiac events MACE was observed in 1- and 2-year follow up. 