 - persistent or recurrent symptoms despite continuous medical treatment, at least one typical reflux symptom heartburn regurgitationdysphagiaepigastric pain andor at least one atypical reflux symptom cough asthmahoarsenessdistortion of taste, pathologic esophageal acid exposure as documented by a reflux-related DeMeester score 14.7, and symptom correlation 50, andor reflux episodes 73. 