 - Uncontrolled intercurrent illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, active bleeding diatheses or renal transplant, including any patient known to have hepatitis B, hepatitis C or human immunodeficiency virus HIV, or psychiatric illnesssocial situations that would limit compliance with study requirements; patients with HIV who have adequate cluster of differentiation CD4 counts and who have no requirement for antiviral therapy will be eligible 