 - Suspected first recurrenceprogression of MBPNET since completion of definitive focal - craniospinal irradiation. Disease progression prior to receiving definitive focal - craniospinal irradiation will not disqualify patients from enrollment if they have subsequently failed definitive radiotherapy and are at first recurrenceprogression at time of enrollment. Patients who are unable to receive radiation therapy due to genetic disorders that put them at significant risk for radiation-induced secondary malignancies i.e. Gorlins syndrome or NF1 mutation are eligible for enrollment at first disease recurrenceprogression. 