 Inflammatory processes have been implicated as a cause of schizophrenia Fan, Goff et al. 2007, and the COX-2 inhibitor, Celecoxib, has been shown to reduce symptoms of schizophrenia Muller, Krause et al. 2010. Aspirin, which is also a non-steroidal anti-inflammatory drugNSAID, irreversibly inhibits Cyclooxygenase-1 COX-1 and modifies the enzymatic activity of Cyclooxygenase-2 COX-2, thus inhibiting the formation of prostaglandins and reduces inflammatory reaction. In a study funded by the Stanley Medical Research Institute SMRI recently published, Laan at all Laan, Grobbee et al. 2010 administered add-on 1000mgd of Aspirin to patients with schizophrenia receiving anti-psychotics, and reported reductions in Positive and negative syndrome scale PANSS total and PANSS positive scores without substantial side effects. 