 - In the United States, urothelial carcinoma UC of the bladder is the 4th most common malignancy in men and the 9th most common in women with an estimated 70,980 new cases and 14,330 deaths in the year 2009. Although it is chemosensitive with response proportions of over 50 with conventional cytotoxic regimens, the response durations are short and the median survival of patients with metastatic disease is approximately 14 months. 