 Cycles 2-12 are 4 weeks in duration with BPM31510 administered twice weekly on Tuesdays and Fridays for 4 weeks monotherapy or 4 weeks in duration with BPM31510 administered twice weekly on Tuesdays and Fridays for 4 weeks plus gemcitabine administered on Mondays, Days 7, 14 and 21 combination therapy. Response will be assessed after Cycle 2 10 weeks and patients who continue onto Cycles 2-12 will be assessed every 2 cycles 8 weeks. 