 hemoglobin 9.0 gdL neutrophils 1500 cells μL platelets 100 x 103 μL total bilirubin 1.5 x upper limit of normal ULN aspartic transaminase AST and alanine transaminase ALT 2.5 x ULN without, and 5 x ULN with hepatic metastasis serum creatinine 1ULN,creatinine clearance 50mlmin Cockcroft-Gault equation 