 This study is a multicenter Phase III trial, which aims to determine the Recommended Phase 2 Dose RP2D of pazopanib in combination with TMZ. The study coordinator will associate a multidisciplinary approach involving translational pharmacokinetic studies, and research on potential predictive biomarkers of response through pharmacogenetic and pharmacogenomic approachs. This study will include patients with not previously treated GBM, candidates for a complete or partial surgical resection and who are eligible for adjuvant treatment based on a combination of TMZ and radiotherapy. 