 Evidence also suggests that atypical neuroleptics, such as olanzapine Horrigan et al, 1997b; Malone et al, 2001; Potenza et al, 1999 and risperidone Demb, 1996; Findling et al, 1997; Fisman and Steele, 1996; Hardan et al, 1996; Horrigan et al, 1997a; Malone et al, 1999b; McDougle et al, 1997; Nicholson et al, 1998; Perry et al, 1997 are effective. But the weight gain associated with these agents can be a considerable health risk Pi-Sunyer, 1993; Sjostrom, 1992. For example, olanzapine use has reportedly been associated with increased blood glucose Fertig et al, 1998; Gatta et al, 1999; Ober et al, 1999; Wirshing et al, 1998; Yazici et al, 1998. Ziprasidone is associated with increases in QTc, including in children Malone, unpublished data. 