 In patients undergoing cardiac surgery employing moderate hypothermic CPB age 20-71 years, n32, ANH will be randomly applied to 15 patients Group-ANH but not in 17 patients Group-C before initiating CPB. For ANH procedure consisting of 5 mlkg of blood salvage and administering 5 mlkg of balanced hydroxyethyl starch HES 1300.4 for 15 min will be started at 30 min after anesthesia induction and before CPB application for surgery. In both groups, moderate hypothermic CPB will be initiated by using 1600-1800 ml of bloodless priming solution. The changes of hematocrit Hct, Na, K, HCO3-, Ca2, osmolarity, s-Cr will be determined before ANH T1, after the first ANH of 2.5 mlkg T2, and after the second ANH of 2.5 mlkg T3, 30 sec and 60 sec after the initiation of CPB T4, T5, immediately and 1 hour after the weaning from CPB T6, T7 and at the end of surgery T8. S-Cr will be determined by using a point-of-care test device StatSensorTM Creatinine, Nova Biomedical, USA. 