 1. Baseline Visit visit 1: once blood and stool samples have been collected the patients will be randomized to probiotic or placebo treatment. At this visit patients will begin their randomly assigned treatment condition to probiotic Lactobacillus helveticus R0052 and Bifidobacterium longum R0175 or placebo. The patients will be provided with 60 sachets probiotic or placebo and instructed to consume 2 daily sachets with or just after breakfast. At each of the following visit they will be provided with additional 60 sachets. 