 unstable angina pectoris, symptomatic congestive heart failure, myocardial infarction 6 months prior to inclusion, serious uncontrolled cardiac arrhythmia, active or uncontrolled severe infection, cirrhosis, chronic active hepatitis or chronic persistent hepatitis, severely impaired lung function spirometry and Diffusing Capacity of the lung for carbon monoxide 50 or less of normal and O2 saturation 88 or less at rest on room air, active, bleeding diathesis 