 60 patients with stage IIIbIV NSCLC will be randomly divided into group Areceive D-CIK treatment and chemotherapy or group Bjust receive chemotherapy,and the randomize ratio will be 1:1. Patients in group A will receive 3 cycles of D-CIK treatment every 1 months and 4 cycles of chemotherapy every 2 weeks.Patients in group B will receive only 4 cycles chemotherapyevery 2 weeks. 