 RISKS, BURDENS AND BENEFITS Patients will be informed of all risks and benefits anticipated using the Participant Information Sheet. The investigators cannot guarantee any treatment benefits and do not yet know what the results will show. However, patients will be helping us understand an important problem affecting many other similar patients. These patients may benefit from this research in the future. With their consent, a lay summary will be circulated to the patients and controls after the completion of the study to inform them of the results of the work. They will be consented for this and informed of this in the participation sheets. Their preferred contact details will be stored separately in the index spreadsheet on the trust computer system and will not be linked with clinical data. 