 Following successful cardiopulmonary resuscitation CPR after out of hospital cardiac arrest OHCA, 50 of patients admitted to the Intensive Care Unit ICU die. As most patients die due to brain damage sustained during cardiac arrest and the subsequent reperfusion phase, effective neuroprotective strategies could potentially improve outcome. In animal experiments, 2-Iminobiotin 2-IB, a selective neuronal and inducible nitric oxide synthase NOS inhibitor, given upon reperfusion has been shown to improve memory function. Since 2-IB has not shown any safety issues in preclinical and clinical studies. Before embarking on large studies with efficacy as primary endpoint, safety, tolerability and pharmacokinetics need to be established. 