 - Have evidence of at least 1 of the following in the 5 years prior to screening or during screening, reversible airway obstruction greater than or equal to 12 percentage change in forced expiratory volume in 1 second FEV1 postbronchodilator; Diurnal variation in peak expiratory flow rate PEFR greater than or equal to 30 percentage change and airway hyperresponsiveness 