 - No contraindications for chemotherapy, with enough liver function and renal function and normal ECG recording Peripheral hemogram: neutrophil1.5×109L, Plt100×109L, Hgb90gL Renal function: serum creatinine1.5 folds the upper limit of normal ULN For patients with non-metastatic liver dysfunction:alanine aminotransferase and aspartate aminotransferase2.5 ULN, For patients with metastatic liver dysfunction: alanine aminotransferase and aspartate aminotransferase5 ULN 