 Subjects with an acute depressive episode n 20; 10 females; mean age SD age, 32.2 10.3 years; number of episodes 2.7 1.9; age of onset 26.7 9.1 years were recruited from the inpatient department of psychiatry at the University of Zurich. All patients were either medication naïve or not on any psychotropic medication for at least 6 weeks prior to study enrollment. Participants were entered into the study after a full explanation of the purpose of the study and the study procedures and after written consent was obtained as approved by the University of Zurichs institutional review board. 