 Randomized clinical trial pragmatic trial, in which 120 adult patients with confirmed SLE diagnosis will be followed for 12 months, and randomized in two groups: the intervention group attended by a pharmacist according to the Dader Method for Pharmaceutical Care, and the control group attended by a non-pharmacist professional with counseling on hygienenutrition and reduction of risks in lupus therapy. The main outcome will be adherence to drug therapy and secondary outcomes the improvement of the medical condition and the quality of life of the patients. 