 - Use of any prescription medications except acceptable forms of birth control and hormone replacement, natural health products, or recreational drugs within 14 days or 5 elimination half-lives whichever was longer prior to first drug administration or throughout the study, unless in the opinion of the investigator or designee, the product would not interfere with the study procedures or data integrity or compromise the safety of the subject. In particular medications that prolong the QTQTc interval e.g. erythromycin, antipsychotics, tricyclic antidepressantswere strictly avoided. 