 Thirty-six patients with suspected MERD positive GerdQ but normal conventional endoscopy and eighteen asymptomatic control were recruited. The new FICE EPX-4450HD was performed at non-magnified, x50, and x100 zoom levels. The criteria for positive FICE were; A triangular indentation, B punctuate erythema, C villiform mucosa, or D increased number of capillary vessel. At the same session, pCLE was applied to count the number of intrapapillary capillary loops IPCLs by using more than 5 IPCLs in 500x500 micron area as a criterion for MERD diagnosis. The validity scores of both modalities and interobserever agreement of pCLE interpretation was assessed. 