 - Arm A relapsed or refractory CLLSLL and require treatment in the opinion of the Investigator. Subject must have relapsed following or be refractory to standard treatments such as fludarabine based regimens F, FC, FR, FCR or alkylator chlorambucil, bendamustine based regimens. In addition, there are no other curative options, and the subject has exhausted options that would be considered standard of care, or 