 8. Patients with significant atherosclerotic disease, as defined by: a myocardial infarction within six months of enrollment, uncontrolled unstable angina pectoris or electrocardiographic evidence of acute ischemia b clinically significant ventricular arrhythmias, c symptomatic congestive heart failure d significant conduction abnormalities: 2nd or 3rd degree AV blocks, bifascicular block defined as Left Anterior Hemiblock in the presence of Right Bundle Branch Block, e claudication limiting activity and f history of cerebrovascular events within the last year including TIA 