 Baclofen is an agonist of the amino-butyricum B GABA-B receptor used for a long time in neurology to treat spastic contracture. Several clinical studies have suggested its efficacy in the treatment of alcohol-dependence in low, even in case of cirrhosis and high dose. French drug authority has authorized its use in 2012 whereas the lEuropean Association for the Study of the Liver recommends to perform additional studies on this indication. 