 We compare indices of central CRF activity i.e. ACTH and cortisol response to CRF stimulation test before and after 8 weeks of treatment with either fluoxetine or placebo between women with a history of childhood abuse early life stress, ELS and current major depression ELSMDD, women with a history of childhood abuse without major depression ELSnon-MDD, and women without a history of childhood abuse and major depression non-ELSMDD. Changes in neuroendocrine responses to CRF are correlated with psychological outcome measures. We hypothesize that treatment with fluoxetine will normalize altered neuroendocrine responsiveness in cases with ELS and that this normalization will be correlated with improvement of symptoms of depression and anxiety. 