 - Adequate bone marrow, hepatic, renal and coagulation function as defined by the following: Absolute neutrophil count 1.5 x 109L, Hemoglobin 9.0 gdL 90 gL, Platelets 100 x 109L, Aspartate aminotransferase AST and alanine aminotransferase ALT 2.5 x upper limit of normal ULN if no hepatic metastases. If hepatic tumor involvement, AST and ALT 5 x ULN, Bilirubin 1.5 x ULN, Prothrombin time PT international normalized ratio INR 1.5 x ULN, Calculated creatinine clearance 50 mLmin using the Cockcroft and Gault equation 