 Patients 18 years of age and older with advanced HIV-1 infection, who do not respond to approved antiretroviral therapy, may be eligible for this study. Candidates must have a CD4 lymphocyte count less than 100 cellsmm3 and a viral load greater than 10,000 copiesmL. They will be screened with a medical history, physical examination, and blood tests, and may also have an electrocardiogram ECG, chest x-ray and urine test. 