 9. Adequate function of major organs bone marrow, heart, lungs, liver etc.. WBC 3,500mm3 and 12,000mm3. Hb 10.0 gdl. Platelet count 100,000mm3. GOT and GPT 2.5times the upper limit of normal excluding liver metastasis. T-Bil 2.0mgdl. Creatinine 1.5 mgdl but if it is 1.0 1.5 mgdl, the dose of S-1 can be decreased according to the dose reduction criteria to allow registration in the trial. Normal ECG not considering clinically unimportant arrhythmias and ischemic changes. 