 - Induction therapy: All Patients receive doxorubicin IV over 15 minutes on days 1 and 22; vincristine IV on days 1, 8, 15, 22, and 29; oral prednisone 3 times daily on days 1-28; and intrathecal IT methotrexate on days 1, 8, and 22 patients with central nervous system CNS disease at diagnosis receive additional methotrexate IT on days 15, 29, and 36. 