 A target venous leg ulcer is identified at screening and patient eligibility is confirmed at screening and then again at the beginning of the Day 0 baseline visit. A patient enrolled in the study may have multiple ulcers on the same or either leg; in this case, all ulcers will be treated with Granexin gel, but only ulcers meeting the following criteria will be designated as the target ulcers and will determine eligibility: 15cm2 of least 4 weeks duration in post debridement. 