 Number of patients to be included: To calculate the number of patients to be included, the investigators fixed Type 1 error: 0.05 and Type 2: 0.10, Power 0.8. It was assumed that no differences should be registered between biopsy and surgery in the Ki-67 or apoptotic indices in the absence of treatment and considered a 30 decrease in Ki-67 a positive result. Unpublished data suggest that 37.3 of patients have PRAPRB higher than 1.5 indicating that around 80 biopsies will be studied by WB to meet the right number. 