 All patients of the two groups will receive the optimal therapy for their conditions, according to good medical clinical practice GMP, with appropriate antibiotic therapy, vasoactive and infusional therapy.All treatments except from Pentaglobinplacebo will not be changed and will be at the discretion of the doctor whos in charge of the patient.At the time of inclusion, the following data will be collected: gender, age, anthropometric parameters, ICU admission diagnosis, known or suspected infection, results of microbiological tests. Prior to initiating therapy T0, after 24 hours T24 and at the end of therapy with IgGAM conjugate sublingual microcirculation will be evaluated by Incident Dark Field Imaging Medical imaging, Cytocam, IDF Braedius, Amsterdam, The Netherlands and tissue oxygenation by using Near Infrared Spectroscopy technique NIRS, InSpectra TM Model 650; Hutchinson Technology Inc., Hutchinson, MN, USA. Both techniques are commonly used in our clinical practice and include CE mark. 