 5. Multiple unilateral tumours with different ERPgRHER2 status, grade or type e.g. ductal vs lobular i.e. anything that suggests two or more different cancers. Multifocal disease with homogenous ERPgRHER2 status, grade and type is allowed if at least one lesion is palpable or at least 1.5cm on ultrasound; the largest lesion should be used for sample collection and CRF completion. 