 This is a single center double blinded randomized controlled study comparing the effectiveness of epsilon-aminocaproic acid EACA and tranexamic acid TA in reducing 24hour blood transfusion and chest tube drainage. From October 2008 to September 2011, patients greater than 18 years of age, scheduled for cardiac surgery requiring CPB were consented. Eligible operations included; coronary artery bypass graft surgery CABG, a heart valve repairreplacement, or a concomitant CABG and valve surgery were enrolled. 