 Statistical Analysis Plan The data will be analyzed using SAS 9.4 software. All statistical tests will be two-sided with a significance level of 0.05. Patients who withdraw while on treatment will be included in the data analysis for each time point before withdrawal. Baseline and follow-up measurements of safety, tolerability, numbers of pathogenic bacteria, wound infection persistence or worsening, and gross effects on the rate of wound healing will be summarized using descriptive statistics such as mean, median, standard deviation, interquartile range, frequency, and percentage where appropriate. Normality assessments for the continuous variables will be completed using Shapiro-Wilk tests and stem-and-leaf plots. 