 Receiving anti-epileptic drugs that are known to be strong inducers of CYP3A4. Prior or current anti-angiogenic therapy for patients with GBM. Radiation therapy within 4 weeks 12 for GBM prior to the first dose of study drug or limited field radiotherapy within 2 weeks 12 weeks GBM prior to the start of study treatment. Any persistent side effect of prior radiotherapy must be resolved to Grade 1 prior to the first dose of study drug. 