 The dual blockade of the RAAS plus bisoprolol is used to increase the effect of angiotensin receptor 1 blockers ARBs. Therapy then requires sequentially adding an angiotensin converting enzyme ACE inhibitor to reduce the levels of angiotensin Ang II resulting from blockage of the Ang II receptor and then to administer a beta-blocker to decrease the elevated renin secretion due to both the ACE inhibitors and ARBs Objective: This study, which compares two antihypertensive treatment regimens in patients with RH, has the following objectives: to demonstrate the therapeutic efficacy of SNB against DBB in RH patients, and to assess the side effects and adherence to treatment over 20 weeks of treatment. 