 - At screening, patients with 3 CNS metastases and each 1 cm size that were treated with either surgical resection andor radiation therapy may be included. Patients may be included if the largest lesion is 1 cm, and there is no evidence of progressive CNS disease on brain imaging at least 30 days after definitive treatment, and if the patients with CNS metastases are not taking prednisone 10 mg or equivalent daily. 