 Study Design and Drug Regimens The study will be months open label parallel comparison with a blinded rater of combination therapy lamotrigine 25-200 mgdayflexible dosing and sodium valproate flexible dosing monotherapy for treatment of mixed mania in two groups of patients with Bipolar Mood Disorder I. The study will have acute and maintenance phases. Each group will consist of 18 subjects matched for age, gender, and education. 