 In case chemotherapy i.e. capecitabine andor oxaliplatin is discontinued for reasons of toxicity, treatment with bevacizumab arm A or bevacizumab cetuximab Arm B should be continued until progression or unacceptable toxicity. Also, if chemotherapy plus bevacizumab is discontinued in Arm B for reasons of toxicity, treatment with cetuximab should be continued until progression or unacceptable toxicity. 