 4. Hemoglobin 90 gL No blood transfusion within 14 days, Absolute Neutrophil Count 1.5×109L, Platelet Count 75×109L, Serum Bilirubin 1.5×ULN, ALT and AST 3.0×ULN without liver metastases, ALT and AST 5.0×ULN with liver metastases, Serum Creatinine 1×ULN, Endogenous Creatinine Clearance60mlmin 