 - routine laboratory Parameters, indicating relevant liver-, pancreas- or kidney injury, an acute infection, anaemia or lack of vitamins ASAT, ALAT twofold of the standard at screening, gamma-GT, lipase threefold of the standard, CRP 15 mgl, creatin indicating a moderate renal insufficiency eGFR 60 mlmin, leucocytes 12000μl, haemoglobin 7,5 mmoll men or 6,5 mmoll women, MCV 100 fl 