 - Men and women aged 18 or older: Women of child bearing potential must have a negative urine pregnancy test during the ScreeningOpioid Induced Constipation OIC ConfirmationBaseline period, a history of no sexual activity or consistent use of an effective birth control method for at least 12 weeks prior to the study, and agreement that no sexual activity or the method of birth control will be continued during the study and for a period of 8 weeks after it ends; male patients who are sexually active must agree to use a barrier method of contraception condom with spermicide from the first dose of Investigational Product until 12 weeks after their last dose 