 - Histologically confirmed UC of the bladder, urethra, ureter or renal pelvis with RbCDKN2A- based on immunohistochemistry IHC of tissue blocks or unstained slides performed within a CLIA-certified laboratory at UNC; if stage I of original cohort indicates futility, molecular requirement for eligibility will change to RbCCND1 overexpression also based on IHC; see statistical section, section 8.0 