 - Patients were not permitted to receive the following drugs: phenytoin, carbamazepine, rifampicin, phenobarbital or itraconazole because of their potential to affect the metabolism of EGFR-TKIs and reduce its plasma concentration. Patients were not permitted to receive oral medicine such as CoumadinTMWarfarin. If anticoagulant therapy is needed,low molecular heparin is suggested to instead of Coumarin drugs; 