 - Measurable disease at least 1 lesion of 1.5 cm in diameter as detected by CT or the CT images of the PETCT; NOTE: patients with Waldenstrom macroglobulinemia are not required to have measurable disease by CT or PETCT if monoclonal protein is detectable by serum protein electrophoresis andor immunoglobulin M IgM level is at least 2 times upper limit of normal 