 - Subjects who require rescue analgesic medication during the study will be allowed to use increased doses of their current pre-study opioid andor non opioid analgesics as clinically indicated e.g., non-steroidal anti-inflammatory medications, acetaminophen, COX-2 inhibitors, topical analgesics. Subjects will be allowed to use a new analgesic for a limited time for non-neuropathic pain e.g., headache, sinusitis, strained muscle, minor ache and pain, but will be prohibited from initiating therapy with a new analgesic agent and use it continuously throughout the remainder of the study. 