 However, there is concern about possible negative effect of multiple course of ANC on birthweight, head circumference and growth later in childhood. Data from numerous animal studies suggest that ANC has a negative effect on pre- and postnatal growth. Most studies deal with rodents who have a short gestation and period of growth 10,11,12,37. In animal studies multidose ANC exposure has also decreased lung growth, which seems to be irreversible and persistent into adulthood 10,11,12. Also, in several animal studies ANC exposure has shown decreased brain growth and cell proliferation, which may also be due to short duration of gestation and long duration of exposure 10,11,12,37. 