 - PAH diagnosis confirmed by hemodynamic evaluation performed prior to screening and showing all of the following: Mean pulmonary artery pressure mPAP 25 mmHg at rest; Pulmonary capillary wedge pressure PCWP or left ventricular end diastolic pressure LVEDP 15 mmHg; Pulmonary vascular resistance PVR at rest 3 Wood units; Not meeting the criteria for a positive vasodilator response fall in mPAP 10 mmHg to 40 mmHg. 