 - Quality of Life QoL Measures using EQ5D The impact of NAC and surgery on patient quality of life will be assessed using A validated questionnaire. The investigators will assess subjective changes in patients state using a a questionnaires. The questionnaires will be self-completed by the patient, taking about 15-20 minutes in total. The questionnaires to be used will be EQ5D which has been recommended for use as a generic PROM following major surgery. 