 5. Patients must have normal organ and marrow function measured within 7 days prior to the initiation of therapy as defined below: a. Absolute neutrophil count 1,500mcL; b. Hemoglobin 9gmdL; c. Platelets 100,000mcL; d. Total Bilirubin 1.5X ULN; e. AST and ALT 2.5x upper limit of normal unless the liver is involved with tumor, in that case, AST and ALT must be 5x upper limit of normal; f. Creatinine clearance 50 mLmin assessed by Cockcroft Gault estimation and creatinine 1.5 x ULN. 