 Statistics: Normally distributed data are described as mean, standard deviation SD and 95 confidence intervals CI and tested with Students t-test for paired data, unpaired data are tested by unpaired t-test and repeated measurements. Non-normally distributed data are described as median and range and tested by the Mann-Whitnew U-test or Wilcoxons sign rank test. When testing 3 or more variables the Friedman test is applied. Pearsons test is applied in correlation analyses if conditions are met or Spearmans Rho. Frequencies are compared by Fischers exact test. Associations between variables are reported as odds ratios and 95 CI. 