 The proposed project is a prospective, randomized, controlled, single-blind study comparing the motor improvements resulting from Constraint-Induced Movement Therapy CIMT and Lakeshore Enriched Fitness Training LEFT for traumatic brain injury TBI in veterans and civilians. Over the course of two years, there will be a total of 80 subjects randomly assigned to 4 conditions. Treatment, testing, and follow-up testing will be carried out in the first 3 grant years and the 1-year follow-up will be completed in the fourth year. Clinical testing will be conducted at pre-treatment, post-treatment, and 1-year follow-up. Longitudinal neuroimaging studies to determine the treatment change in white matter, grey matter, and functional brain connectivity will be carried out across the above-noted time points by different diffusion tensor imaging DTI analysis variants, voxel-based morphometry VBM analysis of structural magnetic resonance imaging MRI scans, analysis of resting state functional MRI fMRI, and analysis of fMRI during hand movement. 