 Most of mortality from advanced chronic liver disease ACLD is mediated by so- called specific complications of end-stage liver disease ESLD; one of the most important is infection 25-30. Infection is responsible for considerable proportion of ESLD-related mortality. Important in pathogenesis of infections in ESLD is CAIDS cirrhosis - associated immune dysfunction syndrome, recently re-named to CAID Cirrhosis-Associated Immune Deficit. TRANSFER FACTOR TF is supposed to act at several points in CAID - cascade. This gave rise to hypothesis, that TF could be of benefit in ADACLF. 