 - Current use or anticipated inability to avoid use of drugs that are known potent cytochrome P450 3A4 CYP3A4 inhibitors ie, grapefruit juice, verapamil, ketoconazole, miconazole, itraconazole, erythromycin, clarithromycin, ergot derivatives, indinavir, saquinavir, ritonavir, nelfinavir, lopinavir, and delavirdine. 