 Also during treatment, participants will have a complete physical examination by a physician or their designated representative such as a nurse or physician assistant each week of treatment. Bone Scan andor CT Scan will be done if necessary. Participants will have blood tests done every week during study. A special blood test, called the 20S proteosome, will be done weekly during Cycles 1 and 2 to evaluate the activity of the drugs. Blood will be collected before you receive treatment and then at 1-2 hours afterward. About 2 teaspoons of blood will be collected each time for this. Bone scan, chest x-ray andor CT scans will be repeated during the study every other course. 