 Specific Aim 2: To estimate magnetization transfer ratios MTR bilaterally in the frontal white matterhead of the caudate nucleus and the putamen in patients with MDD and controls and to examine the relationship between MTR and MRS measures in the dorsolateral white matter. Hypothesis a: MTR will be significantly lower in normal appearing dorsolateral white matter regions and subcortical nuclei caudate nucleus and putamen in patients with MDD when compared with controls. 