 For outpatients acute liver injury, stable cirrhotics, non-cirrhotic liver disease, the investigators will ask them to attend the ward or the outpatient department for collection of biological samples. The investigators will take 25 mls of blood as above, along with a urine and stool sample if they are able to provide this at their first attendance. Breath analysis will also be undertaken during this visit to the hospital, after a 4 hour fast with the exception of water. Outpatients will then be asked to return one month later, when further blood 25mls, urine and stool samples will be collected. 