 Several studies have shown beneficial effects of glucagon-like-peptide-1 GLP-1 on the cardiovascular system. Native GLP-1 is secreted from L-cells in the intestine as GLP-17-36 1 but is rapidly metabolised by the ubiquitous enzyme dipeptidyl-peptidase-4 DPP4 to the metabolite GLP-19-36. However, the physiological effect of GLP-1 on the cardiovascular system is complex and there seems to be a dual function with intact GLP-1 7-36, acting through the GLP-1 receptor, and the GLP-1 9-36 metabolite acting independently of the GLP-1 receptor. 