 The clinician version of the structured Clinical Interview for DSM-IV SCID is a brief structured interview for major Axis I disorders in DSM-IV including major depressive disorder, dysthymic disorder, bipolar disorders, psychotic disorders, anxiety disorders, eating disorders, and alcohol and substance abusedependence. The Hamilton Rating Scale for Depression HRSD, 17-item version is an observer-rated measure of depressive symptomatology. The HRSD will be administered at every visit. The Inventory of Depressive Symptomatology-Self-report IDS-SR30 is a 30-item self-report scale that assesses depressive symptom severity. The IDS-SR30 will be administered at every visit. The Hamilton Rating Scale for Anxiety HRSA is a 14-item observer rating scale that assesses the degree and pathology associated with anxiety such as anxious mood, tension, fear, and insomnia. The HRSA will be administered at every visit. Asthma symptoms will be assessed at every visit using the Asthma Control Questionnaire ACQ. Pulmonary function will also be assessed at every visit by spirometry, using equipment meeting the standards of the ATS, and calibrated according to the manufacturers recommendations. Spirometry will be performed according to ATS guidelines, as the best of three acceptable efforts. Spirometry will be measured before, and 10 minutes after, two puffs of albuterol are administered via metered dose inhaler. Bronchodilator response is calculated as post FEV1 - pre FEV1pre FEV1, and converted to a percent improvement. 