 During the study, the whole process of data validation and registry procedures will be implemented by the Principal Investigator of the study, and monitored by the Ethics Committee of the First Affiliated Hospital of China Medical University.There are 2 research supervisors2 ICU doctors to assess the accuracy,completeness and representativeness of registry data, and to report the study process and research results to Principal Investigator.Investigators have also edited a data dictionary including each variable used by the registry and normal ranges of all detection indexes. The standard operating procedures have been formulated to address the registry and data analysis. The feasibility and significance have been assessed carefully and funded by the Health and Family Planning Commission of Liaoning ProvinceNo.LNCC-B01-2014.The sample size is 700 participants over about 1 year through statistic calculation. The plan for missing data and statistical analysis will be implemented by specialized statisticians of China Medical University. 