 Given the emerging concern that pure anti-VEGF inhibition may promote malignant glial cell invasiveness Keunen 2011, we consider essential to combine a multitargeted antiangiogenic agent, such as pazopanib, with the current standard treatment. TMZ was chosen not only because it represents the current standard of care but because of its very good penetration in the brain parenchyma and its low hepatic metabolism, making very unlikely the occurrence of a pharmacokinetic interaction with pazopanib Friedman 2000. Indeed, phase I trials of TMZ in combination with molecules such as RAD001, cilengitide, gefitinib or irinotecan showed no need for dose modification of TMZ. Similarly, the Phase I trials of pazopanib association with paclitaxel or FOLFOX6 have been conducted up to a dose of 800 mg daily, the recommended dose of pazopanib in monotherapy, with standard doses of chemotherapy Tan 2010, Brady 2009. Finally, the study of the toxicity profile of pazopanib and TMZ does not suggest a specific limiting dose escalation adverse event, except perhaps asthenia, thrombocytopenia or ALAT elevation. However, considering the high level of potential toxicity when an ITK is administered with radiations, pazopanib should not be administered in the induction phase of the Stupp protocol. 