 The study is a multi-center, randomized, controlled trial Weight Loss Maintenance Trial MAINTENANCE to determine the effects of two innovative behavioral interventions, each designed to maintain frequent contacts, compared to a usual care control group. Overweight and obese individuals 60 women, 40 African Americans who are taking medication for hypertension, dyslipidemia andor type 2 diabetes will enter a 6-month, weight loss program. Those 800 individuals who lose at least 4 kg approximately 9 pounds will then be randomized into one of three groups: a Personal Contact PC Intervention that provides monthly personal contacts with a trained interventionist, primarily via telephone; an Interactive Technology IT Intervention that provides frequent contacts through a state-of-the-art interactive web-based program supplemented by other communication technologies; or Usual Care UC. The primary outcome will be weight change from the end of the initial weight loss program to the end of the 30-month weight maintenance intervention period. Other outcomes will include weight change in subgroups, prevalence of CVD risk factors, measures of behavior change, and cost of implementation. For each outcome, the Personal Contact and Interactive Technology interventions will be compared to Usual Care and, if different from Usual Care, to each other. To successfully combat the obesity epidemic, clinicians and health care systems must have options that are effective and feasible and that can be provided to large numbers of individuals. 