 12. In addition, patients should have adequate renal function, defined as a serum creatinine 2.5 mg andor creatinine clearance greater than 51 mlmin as calculated by Cockcroft and Gault Equation: Cockcroft and Gault Equation: Creatinine clearance for males 140 - age yrsbody weight kg72 serum creatinine mgdL. Creatinine clearance for females 0.85 x male value 