 The conceptual framework underlying the TEACH Research Program is based on a specific theoretical approach designed to influence adolescent career choice, in this case towards a career in clinical research. The factors responsible for influencing career choice that form the foundation for our investigation are: 1 the importance of role models in career choice; 2 acquisition of knowledge in order to align ambitions; and 3 the participation of students in activities that actively challenge and engage them. These three factors are addressed by the following three components of the TEACH Research Intervention: 1 participation in a research team consisting of a multi-tiered structure of mentors; 2 classroom instruction of clinical research knowledge and career strategies; and 3 a hands-on clinical research experience through an internship on the Hospitalist Project. 