 - Patients who have a serious cardiac condition, such as myocardial infarction within 6 months, unstable angina, sustained ventricular tachycardia, ventricular fibrillation, clinically significant bradycardia, history of syncope, family history of idiopathic sudden death, QTc 450 msec, advanced heart block or heart disease as defined by the New York Heart Association Class III or IV. See ECG guidelines, Section 8.0. 