 3. Patients with serious or uncontrolled medical condition; 1 Abnormalities in cardiac function or clinically significant heart disease such as congestive heart failure, arrhythmia, unstable angina with treatment within 6 months or acute myocardial infarction; 2 Previous history of serious neurological or psychiatric disease; 3 Acute, severe active infection requiring immediate treatmentVirus, Bacteria, Fungal infection; 4 chronic obstructive pulmonary disease requiring oral steroid therapy or Forced expiratory volume 1 secFEV10.8 L less than the test of pulmonary function at rest; 5 If there are other diseases that are deemed inappropriate as a target of the present clinical trial following the Investigators judgment; 6 Congenital or acquired bleeding disorders 