 - Chronic or relevant acute infections including HIV, viral hepatitis and or tuberculosis or evidence of tuberculosis infection as defined by a positive QuantiFERON TB-Gold or T-SPOT test. Subjects with a positive QuantiFERON TB-Gold or T-SPOT test may participate in the study if further work up according to local practiceguidelines establishes conclusively that the subject has no evidence of active tuberculosis. If presence of latent tuberculosis is established, then treatment must have been initiated and maintained according to local country guidelines. 