 There is insufficient data about optimal interval of ANC administration. According to recent studies there is not additive positive effects of the practice of repeating the course of ANC at 7 days intervals. However, it is known that the positive influence of the one course of ANC is not evident after 7 days of administration. It is interesting whether one additional rescue course of ANC given within 24 hours before premature delivery is more effective than single course of ANC. No prospective studies or randomized, controlled trials comparing single versus second rescue course of antenatal corticosteroids have been published. 