 Sample size determination: There are no published reports of thrombin generation assays or thromboelastography in sepsis, or DIC. In our previous studies of patients taking an anticoagulant warfarin, there was a 400 decrement of ETP 1719 to 404. In order to derive a mean ETP with a target width of 100 and 95 confidence interval, assuming a standard deviation of 259, we will need to enroll 100 patients. 