 - Patients of both sexes aged over 16 diagnosed with asthma according to criteria GEMA 4.0. The diagnosis of asthma is assumed when the patient records stating suggestive previous symptoms of asthma with variable airflow obstruction determined by spirometry or meter peak flow or positive bronchodilator test increase of 12 and 200 ml. of FEV1 after inhalation of a bronchodilator or positive test to unspecific bronchoconstriction. 