 A target foot ulcer is identified at screening and patient eligibility is confirmed at screening and then again at the beginning of the Day 0 baseline visit. A patient enrolled in the study may have multiple ulcers on the same or either foot; in this case, all ulcers will be treated with Granexin gel, but only ulcers meeting the following criteria will be designated as the target ulcers and will determine eligibility: 4cm2 in post debridement of at least 4 weeks duration. 