 - Arm A Recurrent glioma: Pathological diagnosis of glioma grade 2-4 is required. All patients are required to have initially undergone fractionated radiation therapy, to between 55 Gy to 70 Gy in fractions of 1.8-2 Gy as part of first line therapy. The diagnosis of recurrence is to be made by the treating physician on the basis of radiological and clinical data. Measurable disease is not required. 