 Due to the change of life style, the incidence of oral cavity mucous membrane disease increased.In this study,been done a large number of pre-clinical practice and some experimental studies, based on the application of metabolomics technology to ultra-high liquid-mass spectrometry metabolomics analyzer as the core means, The metabolism of pattern recognition and combination of modern analytical techniques to measure blood and urine of patients with OLP-specific clearance of endogenous metabolites,and after the intervention of moss drink endogenous metabolites in the body as a whole group of. At the same time, the use of flow cytometry,,ELISA, immunohistochemistry and other modern technology, research OLP patients using clean moss drink before and after treatment of local lesions and peripheral blood CD4 ,CD8 lymphocytes,Th1 cytokines IFN-γ, TNF-α, Th2 cytokines IL-4,10 the dynamic changes. From metabolomics, cellular immunology, inflammation mechanism perspective of local OLP lesions, peripheral blood and changes in endogenous metabolites in the process,,in-depth study of traditional Chinese medicine to drink clean moss multi-component multi-target treatment of this disease mechanism, is widely used in traditional Chinese medicine treatment of OLP provide a theoretical basis for the promotion of Chinese medicine Qingxian Yin in the oral mucosal disease in the application, effectively solve clinical practice problems. 