 The negative effects of perinatal depression on mother and child start early and persist throughout the life-course. Given that 10-35 of children worldwide are exposed to perinatal depression in their first year of life, 16 mitigating this intergenerational risk is a global public health priority. However, there is a dearth of studies on whether a maternal depression intervention can have long-term benefits for either the mother or her child. This is a study of the effectiveness of an extended 36-month peer-delivered depression intervention, the Thinking Healthy Programme PLUS THPP for women and their children in rural Pakistan. 