 neutrophils 1.5×109L, platelets 80×109L, hemoglobin 90gL no blood transfusion within 14 days, serum transaminaseALT and AST 2.5×ULN If liver metastases are present, serum transaminase5×ULN, total bilirubin 1.25×ULN, cholesterol 7.75mmolL and triglyceride1 x ULN, creatinine 1x ULN,creatinine clearance rate 50mlmin Urine protein and confirmed the 24-hour urinary protein1.0 g normal serum calcium, potassium,magnesium, phosphorus INR1.5 and APTT1.5 ULN LVEF: 50 