 Secondarily, the study will evaluate whether patients develop a specific immunologic response to the NY-ESO-1 protein. Blood samples will be obtained at baseline, prior to each vaccination, one week after each vaccination, and at the last study visit for the assessment of NY-ESO-1 specific CD4 and CD8 T-cells. Cytokine secretion by NY-ESO-1 specific CD8 and CD4 T-cells, as a measure of T-cell activation, will be determined by FACS analysis. In addition, humoral immunity will be determined by the presence of NY-ESO-1 specific antibodies which will be assessed in all patients by ELISA. 