 - No significant abnormality on 12-lead ECG at screening, including the following specific requirements: Ventricular rate inside the range 40-90 beats inclusive per minute bpm at screening, PR interval 210milliseconds msec, No pathological Q waves, QRS interval 60 msec and 120 msec, the waveforms must enable the QT interval to be clearly defined and the corrected QT interval by Fridericias method QTcF must be 450msec machine or manual reading based on a single ECG value, or an average from three ECGs obtained over a brief recording period. 