 - Patients who have: history of coronary revascularization, documented LVEF of less than 45, clinically significant atrial andor ventricular arrhythmias including but not limited to atrial fibrillation, ventricular tachycardia, 2 or 3 heart block, documented FEV1 less than or equal to 60 predicted for patients with a history of cigarette smoking greater than 20 packyear within the past 2 years and with symptoms of respiratory distress 