 Recently, the attention has been shifted on the issue of glycemic variability in the Intensive Care Units ICU, that seems to be a better mortality predictor than the simple blood glucose level. A relationship between lower glycemic variability, normal glucose levels range 72-125 mgdl and outcome improving has been investigated. An high glycemic variability its been associated to an increased in-hospital mortality, also in patients having total parenteral nutrition TPN independently from the presence of episodes of hypo or hyperglycemia. Furthermore, an intensive insulinic therapy itself may lead to excessive blood glucose levels fluctuations as it brings to an increased risk of hypoglycemia, usually treated in an aggressive way. A recent retrospective study has evaluated the impact of glycemic variability and hypoglycemia on outcome in non critically ill patients undergone insulin administration during the hospitalization, showing a strong correlation between hypoglycemia and an increasing of mortality rate. A recent work of Arnold and coll. showed that the application of a treatment protocol for hypoglycemia using administration of 50 dextrose in critically ill patients was able to obtain a reduction of glycemic variability, remaining safe in avoiding dangerous hypoglycemia. 