 Androgen deprivation, the elimination of testosterone and its active metabolites, remains the single most effective intervention available for the treatment of advanced prostate carcinoma. This is usually achieved by surgical removal of the testes orchiectomy, by suppressing production of testosterone LHRH agonists andor by blocking the androgens at receptor sites antiandrogens. Unfortunately, androgen suppression does not cure the disease. Most patients progress within 0-5 years, and all patients ultimately progress if the cancer is not eliminated during initial therapy usually prostatectomy or radiation. 