 Preterm birth PTB is one of the leading causes of neonatal morbidity and mortality Goldenberg et al., 2008 Early PTB 34 weeks gestation carries a 7-fold increased risk of Neonatal death . Following PTB, survivors can experience significant long term cognitive, behavioral, emotional, sensory, and motor deficits. Hence, there is growing interest in the identification of women who are at Risk for spontaneous PTB. Many biophysical and biochemical markers have been discovered to identify those women who are at risk for spontaneous PTB. 