 - Concomitant therapies with any alkylating agents e.g. cyclophosphamide, chlorambucil, other immunosuppressant including sulfasalazine and leflunomide, other biological agent particularly anakinra and abatacept and other experimental drug. If patients are on any of these, they need to be off therapies for at least 28 days prior to Baseline Visit to allow for washout. 