 Approximately 95 of testosterone is supplied by the testes, with the remaining 5 supplied by the adrenal glands. The presumption that standard androgen deprivation achieves the optimal level of androgen suppression for patients is based on the levels of androgen which result from orchiectomy. However, because adrenal androgen levels are unaffected by standard modes of androgen deprivation, 5 of the bodys testosterone remains despite hormone therapy. 