 This proposal aims to test the efficacy of a comprehensive approach to improving positive airway pressure PAP therapy acceptance and adherence and sleep quality among patients with SCID. The proposed study is very relevant to the mission of the VA in promoting optimal health for all Veterans, including those with disabilities. To this end, this study is a randomized controlled trial RCT comparing the efficacy of a combined sleep and PAP adherence program, called the BEST program Best practices PAP patient Education ongoing Support and Training. The central aim of this proposal therefore is to test the efficacy between two PAP adherence programs. The study has two main aims. First, the investigators aim to test the efficacy of the educational program in improving adherence to PAP therapy for the first 6 months of use with data available for some subjects for up to 12 months. Second, the investigators will evaluate the impact of the program on sleep quality and on three key areas of function: general functioning using measures specific to SCID patients, respiratory functioning via spirometry and quality of life assessed with measures appropriate for use with patients having limited mobility over the 3-month intervention period. The investigators will also explore whether the intervention is more effective for some subgroups of patients than others. The proposed work is very relevant to VAs patient care mission, addressing a critical need for patients who suffer from disparity in access to high quality care because of their disabilities. The investigators anticipate that the investigators work will yield significant new knowledge that improves the health and quality of life for Veterans living with SCID. 