 In order to explore the effect of repetitive TMS, which has shown to be effective in intractable depression, we will examine resting-state, default-mode network functional connectivity in patients with major depression. We will use a double-blind, sham-controlled design. Our target sample size is 6030 patients will be treated by active rTMS, the other 30 will be treated by sham rTMS. We will apply 10-day course of 10 Hz rTMS on left dorsolateral prefrontal cortex of the subjects. 