 Levels of glutamate and gamma-aminobutyric acid GABA are measured by proton magnetic resonance spectroscopy 1H-MRS in the anterior cingulate cortex ACC and thalamus. Presynaptic Dopamine level is measured with Positron Emission Tomography Computed Tomography PETCT-scanning using 3,4-dihydroxy-6-18Ffluoro-L-phenylalanine 18F-DOPA. Disturbances of the reward system is measured with functional magnetic resonance imaging fMRI . Regional cerebral blood flow and activity in the same regions are measured with Pseudo-continuous arterial spin labelling pCASL. The default mode network, functional and structural connectivity in the associated macro circuits are measured with resting state fMRI, EEG, and diffusion tensor imaging. Structural brain changes in grey and white matter are measured with MRI. Cognitive functions are measured with a neuropsychological test battery, and early information processing with event related EEG and electromyography EMG psychophysiological examinations. Further patients psychopathology will be rated. 