 - iv Molecular relapse defined as: one or more positive polymerase chain reaction PCR assays for the presence of clonotypic immunoglobulin heavy chain IgH or T cell receptor TCR gene rearrangement in patients transplanted for B-or T-cell acute lymphoblastic leukemia, respectively; one or more positive post transplant reverse transcription RT-PCR assays for the presence of BCR-ABL messenger ribonucleic acid mRNA fusion transcripts in patients transplanted for Philadelphia chromosome BCRABL-positive acute lymphoblastic leukemia; for CML a PCR assay of bone marrow BM or peripheral blood mononuclear cell PBMC positive for the presence of the BCRABL mRNA fusion transcript that quantitatively increases by greater than one order of magnitude on a subsequent sample 