 - All patients both men and women considered for participation in GATE study have to be non-insulin dependent diabetics according to Canadian Diabetes Association criteria, namely a fasting serum glucose 7.0 mmolL on two occasions, a casual glucose 11.1 mmoll with symptoms, or a 2-h post-oral glucose tolerance test glucose of 11.1 mmoll with unsatisfactory glycemic control on oral therapy HbA1c 6-10. 