 Hypergammaglobulinaemia is frequently observed in type 1 Gaucher disease GD1, being either polyclonal or monoclonal gammopathies. Polyclonal hypergammaglobulinemia may be related to the presence of autoantibodies. The clinical significance of such antibodies is questioned in Gaucher disease GD, as some cases of immunologic thrombocytopenia and autoimmune hemolytic anemia have also been reported. 