 - In the opinion of the investigator, a likelihood of requiring initiation of immunosuppressant therapy e.g., prednisone 20 mg daily or an equivalent dose of another oral corticosteroid, azathioprine, mycophenolate mofetil, cyclosporine, methotrexate, or dapsone within the 28 days after study entry. Antimalarial dosing must be held constant during the study, but analgesics and NSAIDs may be varied. 