 - Systemic anti-inflammatory agents the use of acetylsalicylic acid for prophylactic use up to 325 mgday is allowed, provided that the patient is on a stable dose and the regimen will remain constant throughout the study. Acetaminophen will be allowed during the study with a maximum dose of 1g i.e., 1000 mg twice daily and for a maximum of 3 consecutive days its use is not allowed within 1 week of each visit. 