 3. Has severe CKD, defined as eGFR 15 mLmin1.73 m2 and 29 mLmin1.73 m2 based on the IDMS traceable15 MDRD equation, according to laboratory results at Screening non-HD patients only Part 1. Patients with a prior history of greater than 2 weeks of dialysis in the past and who have dialyzed in the 6 months prior to dosing on Day 1 will be excluded. Patients who have had temporary dialysis for acute kidney injury will be allowed at the discretion of the Investigator. 