 This is an investigational study. R-HyperCVAD and R-Ara-CMTX are commercially available chemotherapy drugs. AMG 531 is not FDA approved or commercially available. At this time, AMG 531 is being used in this study for research purposes only. About 36 evaluable patients maximum of 50 patients will take part in this study. All will be enrolled at University of Texas UT M. D. Anderson. 