 The study will include a screening phase Visit 1, Days -211, a treatment phase paracetamol IT administration, anaesthesia and surgical procedure: Visit 2, Day 1 and a follow-up phase including an observation period Visit 3, from Day 1 after surgery until discharge, a final visit at discharge and a follow-up day 61. Pain at rest will be assessed at screening and on visit 2 at baseline 0 h, 1, 2, 3, 6, 9, 12, 15, 18, 21, 24, 27, 30, 33, 36, 39, 42, 45 and 48 h after anaesthetic IT injection and at discharge, using a 0-100 mm VAS. 