 - Active or history of autoimmune disease including but not limited to: rheumatoid arthritis RF-positive with current or recent flare, inflammatory bowel disease, systemic lupus erythematosis clinical evidence with ANA 1:80 or greater, ankylosing spondylitis, scleroderma, multiple sclerosis, autoimmune hemolytic anemia, and immune thrombocytopenic purpura. 