 All patient data will be recorded in an internet-based interactive computer database. The URL is The database has been designed by MedSciNet who have extensive experience in designing, maintaining and managing large multicenter internet based studies for national and international organizations WHO, Government of Sweden. The database satisfies all HCA, HIPPA, FDA CRF 21 Part 11, and NIH security protocols. Each study site will have a computer available to the research team for this study. The database is set up to ensure that correct and complete data are entered. The program determines eligibility and will only allow enrollment once the specific inclusion and exclusion criteria are satisfied. If eligible a consent form will be offered to the patient. Once she has signed the consent form she will be formally enrolled following the prompts on the screen. The computer will then randomize her to a treatment group. There will be prompts that will guide the research team through the data collection sheets. There are reminders built in to ensure that essential demographic and primary outcome data are entered. In addition certain fields will not allow data entry if other essential fields are not completed or have incorrect data entered. The program will query any impossible numbers that may be entered in error. This will hopefully reduce errors from data transcription and will ensure that the protocol is adhered to. Adverse event datasheets will be automatically displayed and will require completion prior to continuation of the study once any reportable events are noted. These and all other data will always be available to the Data Safety and Monitoring Board DSMB for analysis as outlined elsewhere in this proposal. 