 Method: A Randomized, double-blind, controlled clinical trial was carried out in forty patients with relapsing remitting MS. All patients were randomized into two groups. One group practiced Lokomat without VR group G1, the other one the Lokomat with VR G2. Both the groups performed 40-1h-training sessions by Lokomat for 3 times a week. A skilled-blinded neurologist and psychologist administered clinical and neuropsychological scales. All the clinical tests were performed at the beginning T0 and at the end T1 of the rehabilitative program. 