 - Subjects must not have a history of anorexia nervosa, untreated hypothyroidism TSH greater than 4.0 mUL for a second generation test, malignancy, pathophysiologic or genetic syndromes associated with obesity i.e., Cushings syndrome, Turners syndrome, Prader Willi syndrome, major psychiatric illness such as bi-polar disorder, ADD, major depression, bulimia, schizophrenia, or psychosis. 