 Participants are defined as persons who have endoscopically confirmed on gastric or duodenal ulcerincluding scar stage, gastritis and dyspepsia confirmed to be H.pylori positive patients in the biopsy and UBT test. For 14 days, participants treated as Esoprazole based bismuth-containing quadruple regimen therapy therapy including Esoprazole 20mg, Bismuth Potassium Citrate 220mg, Clarithromycin 500mg and Amoxicillin Cap Amoxicillin 1000mg BID. After treatment, the healing rate was evaluated in the UBT test and Biopsy at 495days from the first day dosing. 