 Culprit lesions will be defined according to electrocardiographic criteria ST-segment shift or T-wave inversion and angiographic appearances luminal irregularities consistent with lesion ulceration, filling defects consistent with thrombus, or point of angiographic maximal stenosis in patients with NSTEMI and angiographic stenosis 70 in patients with stable angina not responding to at least two anti-anginal medications. 