 This investigation is a randomized controlled trial of RESPECT-Plus, a continuum of promising and evidence-based practices designed to strengthen family protective factors and improve health permanency and well-being outcomes for children born to mothers in treatment for opioid use disorder. Anticipated outcomes of the intervention include fewer reports of supported child abuse or neglect filings in the childs first year of life, fewer days in out-of-home placement; fewer terminations of parental rights in the childs first year of life; and improvements in family functions overall e.g. improved access to basic needssocial determinants of health, improved parental resilience, and decreased maternal depression. 