 3. Suffered from grade II or above myocardial ischemia or myocardial infarction, uncontrolled arrhythmias including QT interval male 450 ms, female 470 ms.Severe or uncontrolled systemic disease such as clinically significant hypertensionsystolic pressure 140 mm Hg andor diastolic pressure 90 mm Hg, and Grade III-IV cardiac insufficiency, according to NYHA criteria or echocardiography check: LVEF50. 