 All patients will be randomized to receive gefitinib or gefitinib concurrent WBRT until progression of disease. Gefitinib concurrent WBRT, patients were given gefitinib 250mg per day concurrently with WBRTwhole-brain radiotherapy . Dose reduction was allowed for intolerable adverse effects such as rashgrade 4diarrheagrade 3-4 or non hematological toxicitygrade 3-4 from 250mg per day to 250mg every other day then to 250mg every three days if needed. WBRT was delivered in 3.0 GyGrayfractions once per day 5 days per week to a total dose of 30Gy 10 fractions. Radiation was delivered as opposed lateral 6-MVMicro Voltage beams with Varian linear accelerator. 