 1. Patient was diagnosed with Grade B-D acute GVHD requiring corticosteroid systemic therapy. The subject may have Grade C or D aGVHD involving the skin, liver, andor gastrointestinal GI tract or may have Grade B aGVHD involving the liver andor GI tract, with or without concomitant skin disease. Acute GVHD is defined as the presence of skin rash andor persistent nausea, vomiting, andor diarrhea andor cholestasis presenting in a context in which aGVHD is likely to occur and where other etiologies such as drug rash, enteric infection, or hepatotoxic syndromes are unlikely or have been ruled out. 