 - The patient must have adequate hematologic, hepatic, and renal function parameters at Screening: White blood cell WBC count greater than or equal to 3,000 cellsmm3; Platelet count greater than or equal to 100,000 platelets mm3; Creatinine serum less than 2.0 mgdL; Total bilirubin less than 2.0 mgdL; Serum glutamic pyruvate transaminase SGPTalanine aminotransferase ALT less than 2.0 x Upper limits of normal; Serum glutamic oxaloacetic transaminase SGOT aspartate aminotransferase AST less than 2.0 x Upper limits of normal 