 - Patient history must include fewer than 3 rescue-free bowel movements RFBM per week during the two weeks prior to screening and experiencing at least one of the following symptoms during at least one-quarter of the Bowel Movements BM experienced during the prior two weeks: hardlumpy stools, straining, or sensation of incomplete evacuationanorectal obstruction rescue-free BMs are defined as using a laxative if not already taking daily laxatives, or if taking daily laxatives, using an additional laxative. 