 It is well documented, that oral methotrexate is effective and safe in the treatment of rheumatoid arthritis and psoriatic arthritis. Still, studies proving its usefulness for the treatment of AS are lacking. To this date, three small randomised and controlled trials to clarify this issue have been conducted. The dose of methotrexate used in these studies was low, only 7,5 - 10 mg per week. One of these studies showed a benefit in the active treatment group. There was no statistically significant benefit of methotrexate in the two other studies. 