 Without adequate debridement, chronically infected wounds persist and form a nidus for the acquisition of antimicrobial-resistant microorganisms. Multiple studies state that patients with chronic wounds were colonized with one or more resistant bacteria, and that the presence of a chronic wound or decubitus ulcer was associated with a statistically increased likelihood of colonization with methicillin-resistant Staphylococcus aureus MRSA, ciprofloxacin-resistant gram-negative bacilli GNB,colonization and infection with ceftazidime-resistant Escherichia coli and Klebsiella pneumoniae. 