 1. Any serious medical condition including but not limited to, uncontrolled hypertension, diabetes mellitus, activesymptomatic coronary artery disease, chronic obstructive pulmonary disease COPD, renal failure, active infection, active hemorrhage, laboratory abnormality, or psychiatric illness that places the patient at unacceptable risk and would prevent the subject from signing the informed consent form. Patients with history of cardiac arrythmias should have cardiac evaluation and clearance. 