 This clinical trial studies individualized temozolomide TMZ in treating patients with stage IV melanoma that cannot be removed by surgery. Drugs used in chemotherapy, such as TMZ, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Giving TMZ at different times, which are determined individually for each patient based on the phase biorhythm of the immune system response against the tumor may allow for a better drug response and may kill more tumor cells 