 Patients will be randomized into two groups treaties and controls: patients in group of the treaties will be submitted to infusion of IgGAM conjugate Pentaglobin at dosage of 250 mgkg IV 5 mLkg per day rate of 0.4 mLkgh, for 72 hours. The controls will receive equal amount of physiological NaCl solution 0.9 as placebo. Neither the patient nor the staff nurses and MD will be aware of the group and of the treatment applied. IgGAM solutions or NaCl 0.9 will be provided by the hospital pharmacy in similar bags. The remaining treatments will not be changed in any way and will be at the discretion of the doctor whos in charge of the patient. All patients of the two groups will receive the optimal therapy for their conditions, according to good medical clinical practice GMP, with appropriate antibiotic therapy, vasoactive and infusional therapy 