 During the second 24 hour dosing period 24-48 hours post first dose of IP, the subject will be away from the clinic off-site and will apply the IP every 5 1 hours. The total number of doses shall not exceed 6 doses in this second 24 hour period. Rescue medication will be made available to subjects during this second 24 hour period. During this second 24 hour period, subjects will complete the VAS painsoreness on movement assessment prior to each IP dose and at 1 hour post each dose of IP. 