 TNFeradeTM will be delivered once a week for five weeks by direct intratumoral injection by using endoscopy or Endoscopic Ultrasound. 5-FU 1000 mgm2day will be delivered via continuous infusion for 96 hours during weeks 1 and 4. Cisplatin 75 mgm2 will be delivered on Day 1 and Day 29 intravenously. The dose of radiation delivered will be 45 Gy in 1.8 Gy fractions for 5 weeks. 