 - Current or chronic history of liver disease, or known hepatic or biliary abnormalities or a history of regular alcohol consumption within 6 months of the study defined as: an average weekly intake of greater than 21 units or an average daily intake of greater than 3 units males, or an average weekly intake of greater than 14 units or an average daily intake of greater than 2 units females. One unit is equivalent to a 285 milliliter mL glass of full strength beer or 425 mL schooner of low strength beer or 1 30 mL measure of spirits or 1 glass 100 mL of wine 