 Combined antiretroviral therapy cART efficiently suppress viral replication in majority of AIDS patients. The morbidity and mortality of the disease has dramatically decreased over the past 20 years. However, chronic human immunodeficiency virus-1 HIV-1 infection lead to profound immune defects in some advanced AIDS patients who often develop with severe opportunistic infections OIs, severe cachexia and other deadly complications, which accounts for the major death group even under cART. Up-to-date, there are no effective immune interventions to restore host holistic immunity for advanced AIDS patients. 