 All patients will be assessed before randomization by history and physical examination, laboratory tests that will include complete blood count, plasma glucose, urea, creatinine, glomerular filtration rate, Na, K, total and direct bilirubin, aspartate transaminase, alanine transaminase, alkaline phosphatase, gamma-glutamyltransferase, albumin, serum protein electrophoresis, coagulogram prothrombin time and INR, urinalysis, chest radiogram and electrocardiogram. 