 For the first 24 hour dosing period, the subject will remain in the clinic on-site. Subjects will apply the first dose of Investigational Product IP at randomization 0 hours and a second dose upon request PRN or as needed. All subsequent doses will be applied every 5 1 hours. The total number of doses shall not exceed 6 in this first 24 hour period. Subjects will also not be allowed to take any rescue medication during the first 24 hour dosing period. 