 1Recruited patients should receive the endoscopic surgery for picking the olfactory mucosa 1 to 2 months before transplantation. The OECs will be cultured and expanded under the rule of GTP. Then, quality control of OECs should be done by immunohistochemical staining positive for GFAP, S100, and P75. Finally, the investigators will transplanted the OECs about 2 to 8 X 10 6 cells in saline into the peri-infarcted area of the brain. 2 Combination with traditional drug therapy such as used the anti-thrombosis reagent or anti-platelet aggregation reagent. 3 NIH-stroke scale NIHSS, European stroke scale ESS, European stroke motor subscale EMS, Barthel IndexBI and MMSE will be performed for each patient to evaluate the therapeutic effect as the primary end points. 4 In addition, MRIDTI TMSMEP will be also checked for each recruitment patient as the secondary end points. 