 Relapsing-remitting RR, secondary-progressive SP and primary-progressive PP MS patients, affecting by neuropathic or nociceptive chronic pain conditions in accord to 1994 International Association for the Study of Pain IASPclassification, will be recruited. Patients complaining any form of headache will be excluded by the study. The investigators will excluded also patients with cognitive impairment Minimental State Examination - MMSE- 21 and psychiatry diseases, in particular depression Back Depression Inventory Scale - BDI - 15. 