 Hemoglobin9gdL Platelet count100x109L Absolute neutrophil count ANC1.5x109L without growth factor support Total bilirubin1.5x upper limit of normal ULN ASTSGOT andor ALTSGPT2.5x ULN Serum creatinine clearance 50 mlmin, by either Cockcroft-Gault formula or by 24-hour urine collection analysis 