 - Patients on potent inhibitors or inducers of CYP3A45, CYP2C19 and CYP1A2 must have discontinued within 2 weeks prior to randomization or 3 weeks for St. Johns Wort. Patients who do not agree to avoid the ingestion of large amounts of grapefruit and Seville oranges and other products containing these fruits, e.g. grapefruit juice or marmalade and not take vitamin E supplements or multivitamin supplements. 