 2. Subject has a history or current evidence of clinically significant allergic except for untreated, asymptomatic, seasonal allergies at the time of dosing or mild allergic reactions to drugs other than those listed in exclusion criterion 16, hematologic, endocrine, pulmonary, gastrointestinal, cardiovascular, hepatic, psychiatric, or neurologic disease. Exceptions to these criteria eg, stable mild joint disease, cholecystectomy, or childhood asthma may be made after discussion with the medical monitor. 