 - Patients who have a significant history of pulmonary disease that necessitates the use of supplemental oxygen, is associated with dyspnea on walking one block or less, or requires inhaler therapy more than once per week will be required to undergo pulmonary function testing within 6 months of screening and will be excluded if forced expiratory volume 1 FEV1, forced vital capacity FVC, or diffusion lung capacity for carbon monoxide DLCO is less than 65 of predicted. 