 Immune Activation persists in HIV-1 infected patients despite efficient antiretroviral treatment. This immune activation is responsible for immune deficiency as well as for non-AIDS related comorbidities, such as non-alcoholic Fatty liver disease, metabolic syndrome or osteoporosis. The goal of this observational transversal multicentric study is to establish the etiologic factors of persistent immune activation in treated HIV-1 infected patients persistent de novo infection of T CD4 cells, microbial translocation, active coinfections, immunosenescence, T CD4 cells lymphopenia, Treg deficiency, its different forms activation of T CD4 cells, T CD8 cells, B cells, NK cells, monocytes, granulocytes, platelets, endothelial cells or general inflammation and the potential correlation between causes, forms of immune activation and emergent comorbidities kidney, bone or liver dysfunction, metabolic syndrome. 