 ---Sample Size and Power Considerations: Based on current available data of the CATIE Clinical Antipsychotic Trials of Intervention Effectiveness conducted in the U.S.A, a 9.5 incidence rate of diabetes in schizophrenics treated with atypical antipsychotics is predicted. In addition, Hagg reported a 12 incidence rate of confirmed type II diabetes among patients treated with clozapine in their cross sectional study.4 We used the Genetic Power Calculator6 to estimate the sample size needed. We defined a power of 0.8, type I error rate of 0.05, with simple and common acceptable parameters, i.e., 