 1. Systemic chemotherapy with CHOP regimen Schedule and Dose for CHOP Cyclophosphamide 750 mgm2 i.v. Day 1 Doxorubicin 50 mgm2 i.v. Day 1 Vincristine 1.4 mgm2d i.v. Day 1 Prednisolone 60 mgm2d p.o. Day 1-7 1.1 Courses will be repeated every 21 days. 1.2 For patients with CR, give at least 2 additional courses for a minimum of 6 courses. 