 - Visit 2: Baseline assessment of the DreaMed MD-AID profile, subjects will perform resting electrocardiography ECG and determination of the maximal oxygen consumption rate VO2max on a cycle ergometer Ganshorn LF8.5GTM and Schiller software, with BG measurements before, at the end of the exercise and 2 hours after exercise. Subjects will be instructed to refrain from physical activity for 48 hours prior to visits 3 - 6. 