 - Serum bilirubin 1.5 mgdL; AST, ALT, and alkaline phosphatase 2.5 × ULN except for: Patients with hepatic metastases: ALT and AST 5 × ULN; patients with hepatic andor bone metastases: alkaline phosphatase 5 × ULN and patients with Gilberts disease: serum bilirubin 5 mgdL 