 Signed written informed consent. Curative resection of colon cancer and upper rectal cancer, which is not planned for radiotherapy. Histologically proved adenocarcinoma of the colon. Stages: T1-4N2M0 LN 4 Age less or equal to 70 years old. Performance status: 0 to 1 ECOG Adequate liver function Bil. 2 mgdl, GOT, GPT 3x normal limit Adequate renal function Cr 2.0 mgdl Adequate bone marrow functionWBC 3500mm3, Platelet 100000mm3 Individual regular follow-up possible. 3.320 Patient who can receive adjuvant chemotherapy within 6 weeks after operation. 