 20. Have had a serious infection eg, hepatitis, pneumonia, or pyelonephritis, have been hospitalized for an infection, or have been treated with intravenous IV antibiotics for an infection within 2 months prior to randomization. The exception being participants whose infection is a direct consequence of their Crohns disease and will be completely resolved with surgery, e.g. participants with an abscess related to penetrating Crohns disease of the terminal ileum who have no sign of infection after surgery. Less serious infections eg, acute upper respiratory tract infection, enteric infections without signs or symptoms or simple urinary tract infection need not be considered exclusions at the discretion of the investigator. 