 This study is designed to compare the effectiveness of reactive focal drug administration RFDA using dihydroartemisininpiperaquine DHAP versus reactive focal test and treat RFTAT using artemetherlumefantrine AL as a routine process for identifying and eliminating malaria transmission as measured through achieving zero seropositivity in children under five in Southern Province, Zambia. These two strategies are potential candidates for expanded malaria operational surveillance and elimination for low malaria transmission areas. 