 - Prior chemotherapy, radiotherapy, therapeutic radionucleotide or immunotherapy within 4 weeks of Day 1 the day of the first rhuMAb 2C4 dose. Flutamide therapy, or other second line hormonal therapies should be withdrawn 4 weeks prior to Day 1. Bicalutamide and nilutamide therapy should be withdrawn 6 weeks prior to starting study medication. 