 - History of other malignancies, except: Malignancy treated with curative intent and with no known active disease present for 5 years before the first dose of study drug and felt to be at low risk for recurrence by treating physician, 2 adequately treated non-melanoma skin cancer or lentigo maligna without evidence of disease, 3 adequately treated carcinoma in situ without evidence of disease, or 4 Gleason 6 prostate cancer under observation. 