 The sample size has been assessed on the basis of the primary objective of the study, based on a significantly higher PVD in the Group of patients treated with IgGAM compared with controls at 72 hours after starting treatment. Assuming an average difference between the two groups at 72hrs of 4 mmmm2 with a SD of 3, nine patients per group would be sufficient with an α error of 0.05 and a power of 80. In total 20 patients will be included 10 per group All data will be collected anonymously, attributing to each selected patient only an alpha-numeric code, into an electronic database password protected, respecting privacy and confidentiality of the data. 