 12. Patients must be at least 4 weeks from radiation therapy. Additionally, patients must be at least 6 weeks from nitrosoureas, 4 weeks from temozolomide, 3 weeks from procarbazine, 2 weeks from vincristine and 4 weeks from last bevacizumab administration. Patients must be at least 4 weeks from other cytotoxic therapies not listed above and 2 weeks for non-cytotoxic agents e.g., interferon, tamoxifen including investigative agents. All toxicities from prior therapies should be resolved to CTCAE less than or equal to grade 1 except for toxicities such as alopecia, or vitiligo. 