 The statistical parameters for controlling the overall response rates and for testing the CR rates are chosen in the following way: The working significance level for all statistical evaluations in this part of the study will be set to alpha0.05. The expected CR rate after R-CHOP is according to the observations about 50; a clinical relevant improvement by R-FC would be a CR rate of 65. Such an improvement should be detected by the one sided Fisher test with a power of about 95. According to these parameters about 246 observations for each treatment would be necessary. To control the overall response rates, a difference of 85 to 95 will be clinically so relevant that initial randomisation should be terminated with a probability of about 95. Overall response rates will be controlled by a restricted sequential procedure. 