 The objective of this study is to demonstrate the efficacy and safety of Neutrolin as a catheter lock solution CLS on prevention of catheter-related bloodstream infection CRBSI, and the incidence of treatment-emergent adverse events in subjects receiving hemodialysis HD for the treatment of End Stage Renal Disease ESRD when compared with heparin 4,000 USP Units4mL 1,000 USP UnitsmL. 