 - On nasal examination, the presence of any superficial or moderate nasal mucosal erosion, nasal mucosal ulceration, or nasal septum perforation Grade 1B - 4 during the screening visit or Day -1, Participants with difficulty in using the nasal spray applicator, Vulnerable individual as defined by the Institutional Review Board IRB e.g. incarcerated person, any condition not identified in the protocol that in the opinion of the investigator would confound the evaluation and interpretation of the study data or may put the participant at risk, no consumption of alcohol-containing products within 24 hours before confinement and throughout confined study period 