 Healthy postmenopausal women with a uterus. Postmenopausal was defined as amenorrhoeic for at least one year prior to screening, or amenorrhoeic for at least six months prior to screening with a serum E2 concentration of 20 pgml and a serum FSH concentration of 40 IUL at screening. If the patient used any kind of steroid hormone therapy prior to the study, a washout period of 6 months for intra-uterine progesterone and oral estrogenprogestagen combination therapy or 12 months for progesterone implants or injections and injected estrogenprogestagen combination therapy was applied. 