<prompt> Please answer with one of the option in the bracket. Write reasoning in between . Write answer in between .Q:A pharmaceutical company conducts a randomized clinical trial in an attempt to show that their new anticoagulant drug prevents more thrombotic events following total knee arthroplasty than the current standard of care. However, a significant number of patients are lost to follow-up or fail to complete treatment according to the study arm to which they were assigned. Several patients in the novel drug arm are also switched at a later time to a novel anticoagulant or warfarin per their primary care physician. All patients enrolled in the study are subsequently analyzed based on the initial group they were assigned to and there is a significant improvement in outcome of the new drug. What analysis most appropriately describes this trial?? A: As treated, B: Intention to treat, C: Modified intention to treat, D: Non-inferiority, E: Per protocol,  <response>: This is a randomized clinical trial comparing a new anticoagulant drug to the current standard of care for preventing thrombotic events after total knee arthroplasty. The key details are that there was significant loss to follow-up, failure to complete treatment as assigned, and some patients switched treatment groups. The question is asking which analysis approach is most appropriate given these issues.An intention-to-treat analysis includes all patients as originally allocated regardless of whether they completed or received that treatment. This maintains randomization and avoids bias. A per-protocol analysis only includes patients who completed the originally assigned treatment, which can introduce bias. A modified intention-to-treat allows for some exclusions but tries to maintain the principles of intention-to-treat. As-treated analyzes patients based on the treatment received regardless of original assignment. Non-inferiority trials aim to show the new treatment is not unacceptably worse than standard care.Given the significant loss to follow-up, treatment nonadherence, and group switching, an intention-to-treat analysis is most appropriate here to preserve randomization and avoid bias.B: Intention to treat 