<prompt> Please answer with one of the option in the bracket. Write reasoning in between . Write answer in between .Q:A 17-year-old female is found to have an inherited deficiency of alpha-galactosidase A. Skin biopsy shows accumulation of ceramide trihexose in the tissue. Which of the following abnormalities would be expected in this patient?? A: Cherry red spots on macula, B: Histiocytes with a wrinkled tissue paper appearance, C: Gargoyle-like facies, D: Corneal clouding, E: Angiokeratomas,  <response>: This is a question about Fabry disease, which is caused by a deficiency of the enzyme alpha-galactosidase A. This leads to accumulation of glycosphingolipids, particularly globotriaosylceramide Gb3, in cells throughout the body. The skin biopsy finding of accumulation of ceramide trihexose indicates glycosphingolipid accumulation, consistent with Fabry disease.Cherry red spots and corneal clouding can occur in Fabry disease but are not specific. Gargoyle-like facies and wrinkled tissue paper cells are seen in Hurler syndrome, a mucopolysaccharidosis, not Fabry disease. Angiokeratomas are a classic dermatological finding in Fabry disease due to accumulation of Gb3 in blood vessels of the skin.E: Angiokeratomas 