<prompt> Please answer with one of the option in the bracket. Write reasoning in between . Write answer in between .Q:A 67-year-old man comes to the physician because of urinary frequency, dysuria, and blood in his urine. He has also had a 4.5-kg 10-lb weight loss over the past 3 months and has been feeling more fatigued than usual. He smoked one pack of cigarettes daily for 40 years but quit 2 years ago. A urinalysis shows 3 blood. Cystoscopy shows an irregular mass on the bladder wall; a biopsy is taken. Which of the following histologic findings would indicate the worst survival prognosis?? A: Dysplastic cells extending into the lamina propria, B: Nests of atypical cells in the urothelium, C: Friable urothelium with ulcerations, D: Disordered urothelium lined with papillary fronds, E: Tubular glands with mucin secretions,  <response>: This is a medical question asking about the worst survival prognosis based on histologic findings from a bladder biopsy in a 67-year-old man with urinary symptoms and a smoking history. The key is to identify which histologic finding indicates the most aggressive or advanced cancer that has the worst prognosis.A: Dysplastic cells extending into the lamina propria 