<prompt> Please answer with one of the option in the bracket. Write reasoning in between . Write answer in between .Q:A 3-year-old girl presents with delayed growth, anemia, and jaundice. Her mother denies any history of blood clots in her past, but she says that her mother has also had to be treated for pulmonary embolism and multiple episodes of unexplained pain in the past. Her prenatal history is significant for preeclampsia, preterm birth, and a neonatal intensive care unit NICU stay of 6 weeks. The vital signs include: temperature 36.7C 98.0F, blood pressure 10254 mm Hg, heart rate 111min, and respiratory rate 23min. On physical examination, the pulses are bounding, the complexion is pale, but breath sounds remain clear. Oxygen saturation was initially 81 on room air, with a new oxygen requirement of 4 L by nasal cannula. Upon further examination, her physician notices that her fingers appear inflamed. A peripheral blood smear demonstrates sickle-shaped red blood cells RBCs. What is the most appropriate treatment for this patient?? A: Hydroxyurea, B: Darbepoetin, C: Epoetin, D: Corticosteroids, E: Intravenous immunoglobulin,  <response>: This is a question about sickle cell disease in a 3-year-old girl. The key findings in the stem are delayed growth, anemia, jaundice, family history of blood clots and preeclampsia, and sickle-shaped RBCs on peripheral smear. This indicates the patient likely has sickle cell disease. The question is asking for the most appropriate treatment.Choice A, hydroxyurea, is a chemotherapy drug that increases fetal hemoglobin production in sickle cell patients, reducing sickling. This makes it a good treatment option. Choice B and C, darbepoetin and epoetin, are erythropoiesis-stimulating agents that could help treat the anemia but do not address the underlying sickling disorder. Choice D, corticosteroids, may help with acute pain crises but are not appropriate long-term therapy. Choice E, IVIG, is used for autoimmune or immunodeficiency disorders, not sickle cell disease.Therefore, the best answer is hydroxyurea as it directly targets the abnormal sickling of RBCs in this patient.A: Hydroxyurea 