<prompt> Please answer with one of the option in the bracket. Write reasoning in between . Write answer in between .Q:A 24-year-old woman comes to the physician because of progressively worsening episodes of severe, crampy abdominal pain and nonbloody diarrhea for the past 3 years. Examination of the abdomen shows mild distension and generalized tenderness. There is a fistula draining stool in the perianal region. Immunohistochemistry shows dysfunction of the nucleotide oligomerization binding domain 2 NOD2 protein. This dysfunction most likely causes overactivity of which of the following immunological proteins in this patient?? A: β-catenin, B: Interferon-γ, C: NF-κB, D: IL-10, E: IL-1β,  <response>: This is a medical question asking about the underlying immunological cause of symptoms in a patient with fistulizing Crohns disease. The key details in the stem are a young woman with crampy abdominal pain, diarrhea, abdominal tenderness, and a perianal fistula, along with dysfunction of the NOD2 protein. NOD2 is an intracellular pattern recognition receptor that detects bacterial peptides and helps regulate the immune response. Dysfunction of NOD2 is associated with increased inflammation and susceptibility to Crohns disease. The choices list various immunological proteins. NF-κB is a key transcription factor that promotes inflammation and is normally held in check by NOD2. Loss of NOD2 function leads to overactivity of NF-κB. The other choices are not directly implicated in NOD2 dysfunction.C: NF-κB 