<prompt> Please answer with one of the option in the bracket. Write reasoning in between . Write answer in between .Q:A 17-year-old girl is brought to the physician by her mother for the evaluation of irregular menstrual bleeding. Menses have occurred at 60- to 90-day intervals since menarche at the age of 12 years. Her last menstrual period was 4 weeks ago. She is sexually active with one male partner, and they use condoms consistently. She reports that she currently has no desire to have children. She is 165 cm 5 ft 5 in tall and weighs 85 kg 187 lb; BMI is 31 kgm2. Examination shows scattered pustules on the forehead and oily skin. There is coarse hair on the chin and upper lip. Fingerstick blood glucose concentration is 190 mgdL. A urine pregnancy test is negative. Which of the following is the most appropriate pharmacotherapy?? A: Danazol, B: Leuprolide, C: Metformin, D: Combination oral contraceptives, E: Insulin,  <response>: This is a patient with signs and symptoms of polycystic ovarian syndrome PCOS, including irregular menses, obesity, acne, hirsutism, and hyperglycemia. PCOS is characterized by hyperandrogenism and insulin resistance. The key points from the question stem are:- Irregular menstrual periods suggestive of oligoanovulation- Signs of hyperandrogenism - acne, hirsutism, obesity- Hyperglycemia- Sexually active and not desiring pregnancy currentlyThe answer choices provide different pharmacotherapy options:- Danazol - androgen that suppresses gonadotropins - Leuprolide - GnRH agonist that suppresses gonadotropins- Metformin - improves insulin sensitivity- Oral contraceptives - provide contraception and suppress androgens- Insulin - treats hyperglycemiaD: Combination oral contraceptives 