<prompt> Please answer with one of the option in the bracket. Write reasoning in between . Write answer in between .Q:A 16-year-old boy comes to the physician because of a painful lesion on the sole of his right foot for 1 month. It has become progressively larger and more painful, making it difficult for him to walk. He does not have any personal or family history of serious illness. Three years ago he was hospitalized for an ankle fracture that required open reduction and internal fixation. He has moderate facial acne for which he is not receiving any treatment right now. His immunizations are up-to-date. Examination shows a 1-cm lesion on the sole of his foot. The remainder of the examination is unremarkable. A photograph of his sole is shown below. Which of the following is the most likely cause of the lesion?? A: Trauma, B: Poxvirus, C: Human papilloma virus, D: Malignant transformation, E: Benign growth,  <response>: Based on the information provided in the question stem, this appears to be a case of a 16-year-old boy with a painful lesion on his foot. The key findings are:- 1 cm lesion on sole of right foot, painful and growing over 1 month- History of ankle fracture and surgery 3 years prior - Moderate facial acne, no current treatment- Immunizations up to date- Photo shows round lesion with central umbilicationThe differential diagnosis includes trauma, infection viral or bacterial, and malignant transformation. However, the photo shows a classic appearance of a plantar wart, caused by human papillomavirus HPV infection. The central umbilication and location on the sole of the foot are typical. HPV is also consistent with his history of acne. Trauma, poxvirus, and malignant transformation would have a different appearance. A benign growth is possible but less likely than HPV given the clinical scenario.C: Human papilloma virus 