<prompt> Please answer with one of the option in the bracket. Write reasoning in between . Write answer in between .Q:A 38-year-old woman presents with generalized weakness and dizziness for the past 3 weeks. Past medical history is significant for systemic lupus erythematosus diagnosed 15 years ago, for which she takes hydroxychloroquine and methotrexate. No significant family history. Her vital signs include: temperature 37.1C 98.7F, blood pressure 12265 mm Hg, pulse 100min. Physical examination reveals generalized pallor; sclera are icteric. Her laboratory results are significant for the following:Hemoglobin 7.3 gdLMean corpuscular hemoglobin MCH 45 pgcellReticulocyte count 6Direct antiglobulin test PositivePeripheral blood smear 7 spherocytesWhich of the following best represents the most likely cause of this patients condition?? A: Methotrexate side effect, B: Red cell membrane defect, C: IgG-mediated hemolysis, D: IgM-mediated hemolysis, E: Chronic inflammation,  <response>: This is a patient with anemia and jaundice. The key findings are:- Low hemoglobin- Low MCH indicating microcytic anemia- Increased reticulocytes indicating increased RBC destruction - Positive direct antiglobulin test indicating immune-mediated hemolysis- Spherocytes on peripheral smear indicating RBC membrane defectGiven the positive direct antiglobulin test, spherocytes, and known history of SLE, the most likely diagnosis is IgG-mediated immune hemolysis. Methotrexate can cause cytopenias but would not cause a hemolytic anemia. IgM-mediated hemolysis is unlikely with a negative history. Chronic inflammation anemia would have a normal MCH and reticulocyte count. C: IgG-mediated hemolysis 