<prompt> Please answer with one of the option in the bracket. Write reasoning in between . Write answer in between .Q:A 62-year-old man returns to his physician for a follow-up examination. During his last visit 1 month ago splenomegaly was detected. He has had night sweats for the past several months and has lost 5 kg 11 lb unintentionally during this period. He has no history of a serious illness and takes no medications. The vital signs are within normal limits. The physical examination shows no abnormalities other than splenomegaly. The laboratory studies show the following:Hemoglobin 9 gdLMean corpuscular volume 95 μm3Leukocyte count 12,000mm3Platelet count 260,000mm3Ultrasound shows a spleen size of 15 cm 5.9 in and mild hepatomegaly. The peripheral blood smear shows teardrop-shaped and nucleated red blood cells RBCs and immature myeloid cells. The marrow is very difficult to aspirate but reveals hyperplasia of all 3 lineages. The tartrate-resistant acid phosphatase TRAP test is negative. Clonal marrow plasma cells are not seen. JAK-2 is positive. The cytogenetic analysis is negative for translocation between chromosomes 9 and 22. Which of the following is the most appropriate curative management in this patient?? A: Adriamycin, bleomycin, vinblastine, and dacarbazine ABVD, B: Allogeneic bone marrow transplantation, C: Imatinib mesylate, D: Splenectomy, E: Splenic irradiation,  <response>: This is a clinical vignette describing a 62-year-old man with splenomegaly, night sweats, unintentional weight loss, anemia, thrombocytosis, teardrop RBCs, nucleated RBCs, immature myeloid cells in the peripheral blood, marrow hyperplasia, and a positive JAK2 mutation. The key findings are splenomegaly, cytopenias, leukoerythroblastosis, hypercellular marrow, and a positive JAK2 mutation, which are classic for myeloproliferative neoplasms. The differential diagnosis includes polycythemia vera, essential thrombocythemia, and primary myelofibrosis. The negative cytogenetics make chronic myelogenous leukemia unlikely. Of the choices given, allogeneic bone marrow transplantation is the only curative option for myeloproliferative neoplasms. The other choices are either palliative splenectomy, splenic irradiation or incorrect ABVD for lymphoma, imatinib for CML.B: Allogeneic bone marrow transplantation 