<prompt> Please answer with one of the option in the bracket. Write reasoning in between . Write answer in between .Q:A 3-year-old boy is brought to the physician for the evaluation of recurrent skin lesions. The episodes of lesions started at the age of 3 months. He has also had several episodes of respiratory tract infections, enlarged lymph nodes, and recurrent fevers since birth. The boy attends daycare. The patients immunizations are up-to-date. He is at the 5th percentile for length and 10th percentile for weight. He appears ill. Temperature is 38C 100.4F. Examination shows several raised, erythematous lesions of different sizes over the face, neck, groin, and extremities; some are purulent. Bilateral cervical and axillary lymphadenopathy are present. What is the most likely underlying mechanism of this patients symptoms?? A: Defective neutrophil chemotaxis, B: NADPH oxidase deficiency, C: Impaired repair of double-strand DNA breaks, D: Defective cytoplasmic tyrosine kinase, E: Impaired signaling to actin cytoskeleton reorganization,  <response>: This seems to be a question about primary immunodeficiencies in a young child. The key features in the stem are:- Recurrent skin lesions since 3 months of age - Recurrent respiratory tract infections since birth- Recurrent fevers since birth- Enlarged lymph nodes - Failure to thrive low weight and height percentiles- Purulent skin lesions and lymphadenopathy on exam - Fever on examThis presentation is most consistent with chronic granulomatous disease CGD, an immunodeficiency caused by defective NADPH oxidase function. NADPH oxidase is needed by phagocytes to kill certain bacteria and fungi. Defective function leads to recurrent life-threatening infections and granuloma formation.B: NADPH oxidase deficiency 