<prompt> Please answer with one of the option in the bracket. Write reasoning in between . Write answer in between .Q:A 45-year-old woman presents to the emergency department due to new-onset symptoms of asthma. She reports that the asthmatic attacks started a week ago. The past medical history includes gastroesophageal reflux disease and hepatitis B. On physical examination, the patient has bilateral foot drop as well as numbness and tingling sensation in all extremities. A complete blood count is relevant for eosinophilia of 9.1 × 108L. Which of the markers below could explain all of the patients current symptoms?? A: ESR, B: p-ANCA, C: HLA B-27, D: Anti-RoSSA, E: Anti-histone antibodies,  <response>: This is a clinical vignette describing a 45-year-old woman with new onset asthma, bilateral foot drop, numbness and tingling in the extremities, and eosinophilia. The key findings are:- New onset asthma in a middle aged woman- Bilateral foot drop and peripheral neuropathy - EosinophiliaThis presentation is most consistent with Churg-Strauss syndrome, which is an eosinophilic granulomatosis with polyangiitis. This is an autoimmune small vessel vasculitis that often presents with asthma, eosinophilia, and neuropathy. The question is asking which antibody marker could explain all of the patients symptoms. p-ANCA is strongly associated with Churg-Strauss syndrome. The other answer choices are not relevant markers for this condition.B: p-ANCA 