<prompt> Please answer with one of the option in the bracket. Write reasoning in between . Write answer in between .Q:A hospitalized 45-year-old man has had mild flank pain since awakening 3 hours ago. He also reports a new generalized rash. Two weeks ago, he was diagnosed with pulmonary tuberculosis. Current medications include isoniazid, pyrazinamide, rifampin, ethambutol, and pyridoxine. His temperature is 38.3C 100.9F, pulse is 74min, and blood pressure is 12872 mm Hg. Examination of the skin shows diffuse erythema with confluent papules. There is no costovertebral angle tenderness. Laboratory studies show:Leukocyte count 9,800mm3Segmented neutrophils 59Bands 3Eosinophils 4Lymphocytes 29Monocytes 5SerumUrea nitrogen 25 mgdLCreatinine 1.9 mgdLUrineWBC 810hpfEosinophils numerousRBC 56hpfRBC casts negativeWBC casts numerousIn addition to intravenous fluid resuscitation, which of the following is the most appropriate next step in management?? A: Initiate hemodialysis, B: Administer ciprofloxacin, C: Discontinue rifampin, D: Perform serum protein electrophoresis, E: Perform renal biopsy,  <response>: This is a patient with pulmonary tuberculosis who is on anti-TB medications including isoniazid, pyrazinamide, rifampin, ethambutol, and pyridoxine. He now presents with flank pain, rash, fever, eosinophilia, acute kidney injury with eosinophiluria. This clinical presentation is most consistent with an acute allergic interstitial nephritis likely secondary to one of the anti-TB medications. The key findings are the rash, eosinophilia, acute kidney injury with eosinophiluria. This indicates an allergic reaction. Since it started after initiating anti-TB therapy, it is likely a reaction to one of those medications. The most common culprit is rifampin.Of the choices given, discontinuing rifampin is the most appropriate next step. Hemodialysis may be needed if the kidney injury is severe, but rifampin should be stopped first. Ciprofloxacin is an antibiotic but is not indicated now. Serum protein electrophoresis and renal biopsy could help make the diagnosis but are not the most urgent next steps.C: Discontinue rifampin 