<prompt> Please answer with one of the option in the bracket. Write reasoning in between . Write answer in between .Q:A 5-year-old boy presents to the pediatrician after his parents noted that he could not sustain physical exertion and would experience muscle cramping. It was noted that after physical exertion the boy experienced severe muscle pain. After a series of biochemical and genetic tests, it was discovered the that the boy had a nonsense mutation in the gene encoding the muscle glycogen phosphorylase. Thus he was diagnosed with McArdles disease. Which of the following mRNA changes would be expected to cause this mutation?? A: UGU - CGC, B: AUG - UCA, C: CUG - AUG, D: UGA - UAG, E: UAU - UAA,  <response>: This is a question about genetic mutations that can cause McArdles disease. McArdles disease is caused by mutations in the gene encoding muscle glycogen phosphorylase. The question states that this patient has a nonsense mutation in this gene. A nonsense mutation changes a codon that codes for an amino acid to a stop codon. This results in a truncated, nonfunctional protein. The choices list different mRNA changes. To cause a nonsense mutation, the mRNA change needs to result in changing an amino acid codon to a stop codon.E: UAU - UAA 