<prompt> Please answer with one of the option in the bracket. Write reasoning in between . Write answer in between .Q:A 4-day-old girl presents with jaundice for the last 2 days. Although the patients parents were initially told that it was neonatal jaundice and would resolve quickly, they think that the yellow color of the patients skin appears to be more obvious today. The patients mother reports that the girl eats well, has normal stool and urine color. Its her first child from the first healthy pregnancy. The patient was born at term via a spontaneous transvaginal delivery without any complications. Family history is significant for a paternal aunt who had 2 babies who died as infants from unknown causes and for a maternal uncle who has unexplained jaundice. On physical examination, the patient is awake, calm, and appears healthy except for the yellow tone of the skin and scleral icterus. Laboratory findings are significant for an elevated level of unconjugated bilirubin. A complete blood count and other routine biochemical blood tests are within expected parameters. The patient is treated with phototherapy, but her hyperbilirubinemia becomes more severe. Which of the following is the most appropriate course of treatment in this patient?? A: Continuation of phototherapy, B: Phenobarbital, C: Plasma exchange transfusion, D: No further treatment needed, E: Furosemide,  <response>: This is a question about neonatal jaundice in a 4-day-old girl. The key findings are:- Jaundice started 2 days ago and is getting worse despite phototherapy - Healthy pregnancy and delivery- Family history of neonatal deaths and unexplained jaundice- Physical exam shows jaundice and scleral icterus - Unconjugated hyperbilirubinemia on labs- Other labs are normalThis presentation is consistent with neonatal jaundice that is not responding to standard phototherapy. The worsening jaundice despite phototherapy is concerning for a hemolytic process or other underlying condition. The family history raises suspicion for a possible inherited cause. The next step would be an exchange transfusion to rapidly lower the bilirubin level and prevent kernicterus.C: Plasma exchange transfusion 