<prompt> Please answer with one of the option in the bracket. Write reasoning in between . Write answer in between .Q:A 48-year-old Caucasian male suffering from ischemic heart disease is placed on a heart transplant list. Months later, he receives a heart from a matched donor. During an endomyocardial biopsy performed 3 weeks later, there is damage consistent with acute graft rejection. What is most likely evident on the endomyocardial biopsy?? A: Granuloma, B: Atherosclerosis, C: Tissue necrosis, D: Fibrosis, E: Lymphocytic infiltrate,  <response>: This is a question about acute graft rejection after a heart transplant. The key information is that the patient had an endomyocardial biopsy 3 weeks after the transplant that showed damage consistent with acute graft rejection. The choices describe different pathological findings that could be seen on a biopsy. Granuloma and Atherosclerosis are not typically findings in acute rejection. Tissue necrosis can be seen but is not the most common or classic finding. Fibrosis can develop over time after rejection but again is not the most typical acute finding. Lymphocytic infiltrate is the classic histological finding in acute cellular rejection, where lymphocytes infiltrate the transplanted heart tissue.E: Lymphocytic infiltrate 