<prompt> Please answer with one of the option in the bracket. Write reasoning in between . Write answer in between .Q:An 3-year-old boy is brought in to his pediatrician by his mother after she noticed that the child was starting to turn yellow. She has not noticed any behavioral changes. On exam, the boy is icteric but is behaving normally. His temperature is 98.8F 37.1C, blood pressure is 10878 mmHg, pulse is 78min, and respirations are 14min. His labs are drawn, and he is found to have an unconjugated hyperbilirubinemia with a serum bilirubin of 15 mgdL. The mother is counseled that this boys condition may require phenobarbital as a treatment to reduce his bilirubin levels. Which of the following is the most likely defect in this child?? A: Absent UDP-glucuronosyltransferase activity, B: Defective liver excretion of bilirubin due to ABCC2 mutation, C: Defective liver excretion of bilirubin due to SLCO1B1 and SLCO1B3 mutations, D: Impaired bilirubin uptake, E: Reduced UDP-glucuronosyltransferase activity,  <response>: This is a clinical vignette about a 3-year-old boy with unconjugated hyperbilirubinemia. The key findings are:- Unconjugated hyperbilirubinemia with high serum bilirubin level of 15 mgdL- No fever, behavioral changes or other concerning symptoms- Mother was told he may need phenobarbital treatmentBased on these findings, the most likely diagnosis is Gilberts syndrome, which is caused by reduced activity of the enzyme UDP-glucuronosyltransferase UGT. This enzyme is responsible for conjugating bilirubin so it can be excreted into bile. In Gilberts syndrome, there is mild unconjugated hyperbilirubinemia due to reduced UGT activity. Phenobarbital can help increase UGT activity and lower bilirubin levels.Choices A and E mention reduced or absent UGT activity, which is consistent with Gilberts syndrome. Choice E of Reduced UDP-glucuronosyltransferase activity seems most accurate for the mild defect seen in this case. The other choices do not fit with the clinical presentation.E: Reduced UDP-glucuronosyltransferase activity 