<prompt> Please answer with one of the option in the bracket. Write reasoning in between . Write answer in between .Q:A 45-year-old woman with a history of alcoholic hepatitis returns to clinic for follow-up after being diagnosed with rheumatoid arthritis and started on NSAIDs. She complains of continued joint effusions and increasing morning stiffness. Given this patients presentation and history, which of the following drugs presents the greatest risk when started for the management of her condition?? A: Cyclosporine, B: Corticosteroids, C: Methotrexate, D: Hydroxychloroquine, E: Etanercept,  <response>: This patient has a history of alcoholic hepatitis, which puts her at increased risk for liver toxicity with certain medications. She has rheumatoid arthritis and is being considered for additional medications to manage her symptoms. The options include various immunosuppressants and disease-modifying anti-rheumatic drugs DMARDs. Methotrexate can cause liver toxicity and would likely pose the greatest risk in this patient with underlying liver disease. Corticosteroids also can worsen liver disease. Cyclosporine, hydroxychloroquine and etanercept have less hepatotoxicity potential.C: Methotrexate 