<prompt> Please answer with one of the option in the bracket. Write reasoning in between . Write answer in between .Q:A 42-year-old man is admitted to the hospital for pain and swelling in his right foot. His temperature is 39.7C 103.5F, pulse is 116min, respirations are 23min, and blood pressure is 6939 mmHg. A drug is administered via a peripheral intravenous line that works primarily by increasing inositol trisphosphate concentrations in arteriolar smooth muscle cells. Eight hours later, the patient has pain at the right antecubital fossa. Examination shows the skin around the intravenous line site to be pale and cool to touch. After discontinuing the infusion, which of the following is the most appropriate pharmacotherapy to prevent further tissue injury in this patient?? A: Procaine, B: Phentolamine, C: Tamsulosin, D: Conivaptan, E: Heparin,  <response>: This is a clinical vignette describing a patient with signs of sepsis high fever, tachycardia, hypotension who developed pain and pale, cool skin around an IV site after being given a drug that increases IP3 signaling in arteriolar smooth muscle. The question asks which drug would be most appropriate to prevent further tissue injury in this patient. The description of pale, cool skin around the IV site indicates the patient may have developed ischemia due to vasoconstriction, likely as an adverse effect of the unspecified IV medication. Therefore, the goal is to improve blood flow to the affected tissue.Choices A and C can be eliminated as they have no significant vasodilatory effects. Choice D is a vasopressin antagonist but would not reverse vasoconstriction caused by increased IP3 signaling. Choice E, heparin, may help prevent clotting but would not reverse vasoconstriction. Choice B, phentolamine, is an alpha-adrenergic antagonist that causes vasodilation. By blocking alpha-receptors in arteriolar smooth muscle, it would reverse vasoconstriction caused by the initial IV medication. Therefore, phentolamine is the most appropriate choice.B: Phentolamine 