<prompt> Please answer with one of the option in the bracket. Write reasoning in between . Write answer in between .Q:A 9-year-old boy with cystic fibrosis CF presents to the clinic with fever, increased sputum production, and cough. The vital signs include: temperature 38.0C 100.4F, blood pressure 12674 mm Hg, heart rate 103min, and respiratory rate 22min. His physical examination is significant for short stature, thin body frame, decreased breath sounds bilateral, and a 26 holosystolic murmur heard best on the upper right sternal border. His pulmonary function tests are at his baseline, and his sputum cultures reveal Pseudomonas aeruginosa. What is the best treatment option for this patient?? A: Inhaled tobramycin for 28 days, B: Dornase alfa 2.5 mg as a single-use, C: Oral cephalexin for 14 days, D: Minocycline for 28 days, E: Sulfamethoxazole and trimethoprim for 14 days,  <response>: This is a clinical case scenario about a 9-year-old boy with cystic fibrosis who presents with symptoms of an acute pulmonary exacerbation, including fever, increased sputum production, and cough. His vital signs show fever and tachycardia consistent with infection. His physical exam reveals findings expected in a patient with CF, including short stature, thin body habitus, decreased breath sounds, and a systolic murmur. His pulmonary function tests are at baseline, suggesting this is not an acute deterioration. Sputum cultures grew Pseudomonas aeruginosa, a common pathogen in CF lung infections. The question asks for the best treatment option. Based on the clinical presentation of an acute pulmonary exacerbation due to Pseudomonas aeruginosa in a patient with CF, inhaled tobramycin would be the best option. Inhaled antibiotics deliver high concentrations to the site of infection while minimizing systemic toxicity. Oral antibiotics like cephalexin do not achieve adequate concentrations in the lungs. Anti-pseudomonal antibiotics like tobramycin are preferred over narrow spectrum agents like cephalexin. Minocycline and sulfamethoxazoletrimethoprim are not first-line agents for Pseudomonas. Dornase alfa is a mucolytic agent and would not treat the underlying infection.A: Inhaled tobramycin for 28 days 