<prompt> Please answer with one of the option in the bracket. Write reasoning in between . Write answer in between .Q:An investigator is studying the genetic profile of an isolated pathogen that proliferates within macrophages. The pathogen contains sulfatide on the surface of its cell wall to prevent fusion of the phagosome and lysosome. She finds that some of the organisms under investigation have mutations in a gene that encodes the enzyme required for synthesis of RNA from a DNA template. The mutations are most likely to reduce the therapeutic effect of which of the following drugs?? A: Streptomycin, B: Rifampin, C: Ethambutol, D: Pyrazinamide, E: Levofloxacin,  <response>: This is a question about an isolated pathogen that proliferates within macrophages and contains sulfatide on its cell wall surface to prevent phagosome-lysosome fusion. It also has mutations in a gene encoding an enzyme required for RNA synthesis from DNA. The question asks which drugs therapeutic effect would most likely be reduced by these mutations.The mutations affect RNA synthesis, so drugs that target RNA synthesis like rifampin would likely be less effective. Streptomycin, ethambutol, pyrazinamide, and levofloxacin have different mechanisms of action not related to RNA synthesis.B: Rifampin 