<prompt> Please answer with one of the option in the bracket. Write reasoning in between . Write answer in between .Q:A 49-year-old female with a long history of poorly controlled diabetes mellitus visits her primary care physician with 2 non-pitting edema in her legs. The patient has a serum creatinine of 2.9 mgdL and a blood urea nitrogen of 61 mgdL. A 24-hour urine collection reveals 8.5 grams of protein. A renal biopsy is obtained. Which of the following histologic findings is most likely to be seen upon tissue analysis:? A: Normal glomeruli, B: Nodular thickening of the glomerular basement membrane, C: Crescentic proliferation in Bowmans space, D: Lymphocytic infiltration of glomerular tufts, E: Non-caseating interstitial granuloma,  <response>: This is a question about diabetic nephropathy. The patient is a 49-year-old female with longstanding poorly controlled diabetes, presenting with edema, elevated creatinine and BUN, and proteinuria on 24-hour urine collection. This clinical presentation is consistent with diabetic nephropathy. The question asks about expected histologic findings on renal biopsy. Choice A can be eliminated, as normal glomeruli would not be expected with diabetic nephropathy. Choice B describes nodular glomerulosclerosis, which is the classic histologic finding in diabetic nephropathy. Choices C, D and E describe findings not typically associated with diabetic nephropathy.Therefore, choice B Nodular thickening of the glomerular basement membrane is the most likely histologic finding in this patient with diabetic nephropathy.B: Nodular thickening of the glomerular basement membrane 