<prompt> Please answer with one of the option in the bracket. Write reasoning in between . Write answer in between .Q:A 37-year-old woman comes to the physician for a 6-month history of headaches, anorexia, and vomiting. She has had a 10-kg 22-lb weight loss during this period. She has type 1 diabetes mellitus for which she takes insulin. The patients mother and sister have hypothyroidism. Her blood pressure is 8060 mm Hg. Physical examination shows hyperpigmentation of the lips and oral mucosa. Serum studies show a parathyroid hormone level of 450 pgmL and antibodies directed against 17α-hydroxylase. Which of the following is the most likely diagnosis?? A: Multiple endocrine neoplasia type 2B, B: Sheehan syndrome, C: Multiple endocrine neoplasia type 2A, D: Autoimmune polyendocrine syndrome type 2, E: Cushing syndromen,  <response>: This is a clinical vignette describing a 37-year-old woman with a 6-month history of headaches, anorexia, vomiting, and significant weight loss. She has type 1 diabetes mellitus and a family history of hypothyroidism. On exam she is hypotensive and has hyperpigmentation. Lab studies show an elevated PTH level and antibodies against 17α-hydroxylase. The key findings here are: - Headaches, anorexia, vomiting, weight loss - suggests an endocrine disorder- Type 1 diabetes mellitus - an autoimmune endocrine condition- Family history of hypothyroidism - suggests genetic susceptibility to autoimmune conditions- Hypotension and hyperpigmentation - suggests adrenal insufficiency - Elevated PTH - suggests hypoparathyroidism- Antibodies against 17α-hydroxylase - indicates autoimmune adrenal insufficiency Given the constellation of autoimmune endocrine disorders including adrenal insufficiency, hypoparathyroidism, and a family history of autoimmune thyroid disease, this clinical presentation is most consistent with autoimmune polyglandular syndrome type 2 APS-2.D: Autoimmune polyendocrine syndrome type 2 