<prompt> Please answer with one of the option in the bracket. Write reasoning in between . Write answer in between .Q:A 37-year-old man presents to the clinic because of painful, severe blistering over his buttocks for the past week. About a year ago, he noticed a similar outbreak on his inner thighs, but it receded within a few days on its own. Physical examination shows the blisters are tense, and rubbing the affected skin does not result in popping of the blisters. A biopsy shows the entire epidermis lifting away from the basal lamina with extensive inflammatory infiltrates abundant with eosinophils. Immunofluorescence shows a linear pattern of immune complex deposits. Which of the following cellular structures, if defective, is most likely involved in the formation of these blisters?? A: Gap junctions, B: Hemidesmosomes, C: Lamellar bodies, D: Macula adherens, E: Zonula occludens,  <response>: This is a question about blistering skin conditions. The key details in the stem are:- Painful, severe blistering over the buttocks- Similar previous outbreak on inner thighs that resolved spontaneously - Tense blisters that do not pop when rubbed- Biopsy shows epidermal-dermal separation with eosinophilic infiltrate- Linear immune complex deposits on immunofluorescenceThis presentation is most consistent with bullous pemphigoid, an autoimmune blistering disease characterized by tense subepidermal blisters and eosinophilic infiltrates. The linear immune deposits point to an autoantibody against a hemidesmosomal protein. Hemidesmosomes are structures that attach the epidermis to the underlying basement membrane. A defect in these structures would cause the blistering seen in this patient.B: Hemidesmosomes 