<prompt> Please answer with one of the option in the bracket. Write reasoning in between . Write answer in between .Q:A 10-month-old boy is brought to the physician by his mother for evaluation of abnormal growth and skin abnormalities. His mother has also noticed that his eyes do not fully close when sleeping. He is at the 24th percentile for height, 17th percentile for weight, and 29th percentile for head circumference. Physical examination shows wrinkled skin, prominent veins on the scalp and extremities, and circumoral cyanosis. Genetic testing shows a point mutation in a gene that encodes for a scaffold protein of the inner nuclear membrane. The mutation causes a deformed and unstable nuclear membrane, which leads to premature aging. Which of the following is most likely to be the defective protein?? A: Desmin, B: Nesprin, C: Vimentin, D: Lamin, E: Plectinn,  <response>: This is a clinical vignette describing a 10-month-old boy with abnormal growth, skin abnormalities, incomplete eye closure during sleep, and physical exam findings of wrinkled skin, prominent veins, and circumoral cyanosis. Genetic testing revealed a mutation in a gene encoding a scaffold protein of the inner nuclear membrane, leading to nuclear membrane defects and premature aging. The key finding is a mutation affecting a protein of the inner nuclear membrane. This narrows down the defective protein to one that localizes to and helps maintain the structure of the nuclear membrane.Choice A Desmin is incorrect as it is a cytoskeletal protein not found in the nucleus. Choice B Nesprin helps connect the nuclear membrane to the cytoskeleton but is not a main structural component of the nuclear membrane itself.Choice C Vimentin is a cytoskeletal protein not found in the nucleus.Choice D Lamin is a protein that forms intermediate filaments providing structural support to the inner nuclear membrane. Mutations in lamin proteins lead to defective nuclear membranes and diseases of premature aging. Choice E Plectin is a cytoskeletal cross-linking protein not found in the nucleus.D: Lamin 