<prompt> Please answer with one of the option in the bracket. Write reasoning in between . Write answer in between .Q:A prospective cohort study is conducted to evaluate the risk of pleural mesothelioma in construction workers exposed to asbestos in Los Angeles. Three hundred construction workers reporting current occupational asbestos exposure were followed alongside 300 construction workers without a history of asbestos exposure. After 8 years of follow-up, no statistically significant difference in the incidence of pleural mesothelioma was observed between the two groups p 0.13, even after controlling for known mesothelioma risk factors such as radiation, age, and sex. Which of the following is the most likely explanation for the observed results of this study?? A: Length-time bias, B: Lead-time bias, C: Latency period, D: Observer effect, E: Berkson bias,  <response>: This is a question about a prospective cohort study looking at the risk of pleural mesothelioma in construction workers exposed to asbestos versus those not exposed. The key results are that there was no statistically significant difference in mesothelioma incidence between the exposed and unexposed groups after 8 years of follow-up. The answer choices represent different types of biases or issues that could explain the lack of observed association between asbestos exposure and mesothelioma in this study.A refers to length-time bias, which occurs when screening detects more indolent disease cases that may never cause symptoms. This is not relevant here since no screening was involved. B refers to lead-time bias, where earlier diagnosis due to screening makes it appear that survival time is longer even if the disease course is unaltered. Again, not relevant here without screening.C refers to latency period, which is the time between exposure and disease onset. Mesothelioma has a long latency period, so 8 years may be too short to see an effect of asbestos exposure. This is a plausible explanation.D refers to observer effect, where the act of observation influences the phenomenon being observed. This is not relevant here. E refers to Berksons bias, a type of selection bias. This is also not relevant here.C: Latency period 