<prompt> Please answer with one of the option in the bracket. Write reasoning in between . Write answer in between .Q:A 66-year-old woman comes to the physician because of a 1-week history of pruritic blister formation. Physical examination shows multiple 13 cm bullae on the palms, soles, lower legs, and inguinal folds. Gentle rubbing of the skin does not result in sloughing of the epidermis. Immunofluorescence studies of a perilesional skin biopsy specimen are most likely to show deposition of antibodies in which of the following areas?? A: At the dermoepidermal junction, B: Between epidermal keratinocytes, C: No staining, D: In dermal papillae, E: In dermal vessel walls,  <response>: This is a clinical vignette describing a 66-year-old woman with a 1-week history of blister formation on her palms, soles, lower legs, and inguinal folds. The blisters are pruritic and 1-3 cm in size. Gentle rubbing does not cause sloughing of the epidermis. We are asked to determine the most likely immunofluorescence findings from a perilesional skin biopsy. Based on the clinical presentation, this patient most likely has bullous pemphigoid. Bullous pemphigoid is an autoimmune blistering disease characterized by subepidermal blistering due to autoantibodies directed against hemidesmosomal proteins BP180 and BP230. On immunofluorescence of perilesional skin, there is typically linear deposition of IgG andor C3 at the basement membrane zone dermoepidermal junction.Choices A and D refer to the dermoepidermal junction and dermal papillae, respectively. Choice B refers to staining between keratinocytes, which would be seen in pemphigus, not bullous pemphigoid. Choice C indicates no staining, which would not be expected. Choice E refers to vessel walls in the dermis, which is not typical of bullous pemphigoid.A: At the dermoepidermal junction 