<prompt> Please answer with one of the option in the bracket. Write reasoning in between . Write answer in between .Q:A 59-year-old man with a history of major depressive disorder, asthma, and erectile dysfunction presents to his family physician complaining of depressed mood, amotivation, overeating, and anhedonia. He currently takes no medications. The patient has a 3 pack-year smoking history and would like to quit but has been unsuccessful in the past. His BMI is 29 kgm2. The physician suggests starting an antidepressant for the patients mood symptoms. The patient is reluctant, as he used to take sertraline, but stopped it after his erectile dysfunction worsened. Which of the following antidepressants would be most appropriate for this patient?? A: Amitriptyline, B: Bupropion, C: Citalopram, D: Mirtazapine, E: Sertraline,  <response>: This is a clinical case about choosing an appropriate antidepressant for a 59-year-old man with depression, asthma, erectile dysfunction, and a history of smoking. The key factors to consider are:- He has erectile dysfunction that worsened with sertraline, so avoiding SSRIs like sertraline and citalopram may be prudent. - He has asthma, so avoiding tricyclic antidepressants like amitriptyline that can worsen breathing issues may be best. - He wants to quit smoking, so bupropion which can also be used as a smoking cessation aid may be a good option.- Weight gain is a potential side effect to avoid, making mirtazapine less ideal.So bupropion seems to be the best option given his comorbidities and medication history.B: Bupropion 