<prompt> Please answer with one of the option in the bracket. Write reasoning in between . Write answer in between .Q:A 23-year-old Sicilian male presents to his primary care physician complaining of lethargy, joint pain, and urinary frequency. Vitals signs include T 98.7 F, HR 96 bpm, BP 13571 mmHg, RR 18 breathsminute, O2 99. Laboratory findings include: random glucose 326 mgdL, Hemoglobin 7.1, and elevated reticulocyte count and transferrin saturation. The patient is not surprised that his blood level is low and suggests that he might need another transfusion. An echocardiogram demonstrates restrictive cardiomyopathy. The disorder with which this patient presents can be characterized by which of the following?? A: Absence of the hemoglobin alpha-chain, B: Absence of the hemoglobin beta-chain, C: Presence of the fetal hemoglobin, D: Mutation resulting in increased iron absorption, E: Mutations resulting in copper accumulation,  <response>: This is a clinical vignette describing a patient with symptoms of lethargy, joint pain, urinary frequency, anemia, elevated reticulocyte count, high transferrin saturation, hyperglycemia, and restrictive cardiomyopathy. The key findings pointing towards the diagnosis are:- Anemia with high reticulocyte count and high transferrin saturation - indicates increased but ineffective erythropoiesis- Restrictive cardiomyopathy - a known complication- Sicilian ethnicity - higher prevalence The disorder is likely a hemoglobinopathy resulting in hemolytic anemia. The high glucose suggests diabetes mellitus may be present as well.Based on the clinical vignette, the disorder is most likely beta thalassemia major. This is characterized by absent beta globin chains. The elevated fetal hemoglobin is a compensatory mechanism attempting to increase oxygen carrying capacity. The increased iron absorption leads to iron overload, resulting in complications like cardiomyopathy.The other options can be ruled out:A Absent alpha chains would lead to alpha thalassemiaB Absent beta chains matches beta thalassemia majorC Fetal hemoglobin is elevated in beta thalassemia due to compensationD Increased iron absorption occurs in beta thalassemia E Copper accumulation does not match the clinical presentationB: Absence of the hemoglobin beta-chain 