<prompt> Please answer with one of the option in the bracket. Write reasoning in between . Write answer in between .Q:A 32-year-old woman presents with a three-month history of difficulty swallowing. She says that it occurs with both solids and liquids with the sensation that food is getting stuck in her throat. Additionally, the patient reports that while shoveling snow this past winter, she had noticed that her hands would lose their color and become numb. She denies any cough, regurgitation, joint pains, shortness of breath, fever, or changes in weight. She does not smoke or drink alcohol. The patients physical exam is within normal limits, although she does appear to have thickened, tight skin on her fingers. She does not have any other skin findings. Which antibody will most likely be found on serological study in this patient?? A: Anti-mitochondrial antibodies, B: Anti-centromere antibodies, C: Anti-topoisomerase antibodies, D: Anti-U1-RNP antibodies, E: Anti-CCP antibodies,  <response>: Based on the description in the question stem, the patient is presenting with symptoms of dysphagia difficulty swallowing and Raynauds phenomenon fingers losing color and becoming numb in cold temperatures. The additional finding of thickened, tight skin on the fingers points towards a diagnosis of scleroderma. Scleroderma is an autoimmune disease that can affect the esophagus, causing dysphagia, and also commonly causes Raynauds phenomenon. The presence of anti-centromere antibodies is associated with limited cutaneous systemic sclerosis, a subtype of scleroderma. Therefore, the antibody most likely to be found in this patient is anti-centromere antibodies.B: Anti-centromere antibodies 