<prompt> Please answer with one of the option in the bracket. Write reasoning in between . Write answer in between .Q:An otherwise healthy 66-year-old man comes to the physician for evaluation of rough skin over his forehead and the back of his hands. He has tried applying different types of moisturizers with no improvement. He has worked on a farm all his life. Physical examination shows two erythematous papules with a gritty texture and central scale over the left temple and three similar lesions over the dorsum of his hands. This patients skin lesions increase his risk of developing a skin condition characterized by which of the following findings on histopathology?? A: Keratin pearls, B: Atypical melanocytes, C: Noncaseating granulomas, D: Basaloid cells, E: Intraepidermal acantholysis,  <response>: This is a clinical vignette describing a 66-year-old male farmer with rough skin lesions on his forehead and hands. The question asks about the histopathologic findings that would be associated with his increased risk for a particular skin condition. Based on the description of erythematous papules with central scaling, the most likely clinical diagnosis is actinic keratoses. Actinic keratoses are precancerous skin lesions caused by cumulative sun exposure, and are more common in fair-skinned individuals with a history of outdoor work like farming. The histopathology of actinic keratoses classically shows atypical keratinocytes, loss of normal epidermal maturation, and keratin pearls. Therefore, the answer is most likely choice A, which describes keratin pearls.Choices B, C, D, and E describe histopathologic findings of melanoma, granulomatous diseases like sarcoidosis, basal cell carcinoma, and pemphigus vulgaris, respectively. These are less likely to be associated with actinic keratoses and significant sun damage.A: Keratin pearls 