<prompt> Please answer with one of the option in the bracket. Write reasoning in between . Write answer in between .Q:A 2720-g 6-lb female newborn is delivered at term to a 39-year-old woman, gravida 3, para 2. Apgar scores are 6 and 7 at 1 and 5 minutes, respectively. Examination in the delivery room shows micrognathia, prominent occiput with flattened nasal bridge, and pointy low-set ears. The eyes are upward slanting with small palpebral fissures. The fists are clenched with fingers tightly flexed. The index finger overlaps the third finger and the fifth finger overlaps the fourth. A 36 holosystolic murmur is heard at the lower left sternal border. The nipples are widely spaced and the feet have prominent heels and convex, rounded soles. Which of the following is the most likely cause of these findings?? A: Trisomy of chromosome 21, B: Maternal alcohol intake, C: Monosomy of chromosome X, D: FMR1 gene silencing, E: Trisomy of chromosome 18,  <response>: This is a clinical vignette describing a newborn with multiple physical abnormalities. The key findings are micrognathia, flattened nasal bridge, low-set ears, upward slanting eyes, overlapping fingers, heart murmur, wide nipple spacing, and abnormal foot shape. This constellation of findings is most consistent with trisomy 18, also known as Edwards syndrome. Trisomy 21 Down syndrome can cause some overlapping features but does not typically cause the hand or foot abnormalities described. Fetal alcohol syndrome can cause growth restriction and some facial features but does not cause the other findings. Monosomy X Turner syndrome and FMR1 mutations fragile X syndrome do not match the clinical picture. Therefore, the most likely diagnosis is trisomy 18.E: Trisomy of chromosome 18 