<prompt> Please answer with one of the option in the bracket. Write reasoning in between . Write answer in between .Q:A 59-year-old man comes to the physician because of a 1-year history of increased urinary frequency, weak urinary stream, and occasional straining to void urine. Rectal examination shows a large, nontender prostate without asymmetry or nodularity. His serum creatinine, prostate-specific antigen, and urinalysis are all within the reference range. A diagnosis of benign prostatic hyperplasia is made, and treatment with tamsulosin is begun. Which of the following changes in intracellular messaging is most likely to occur in response to this drug?? A: Decreased activity of protein kinase A, B: Increased production of diacylglycerol, C: Increased activity of protein kinase C, D: Decreased activity of phospholipase C, E: Increased activity of adenylyl cyclasen,  <response>: This is a question about benign prostatic hyperplasia BPH and the mechanism of action of tamsulosin, which is used to treat BPH. The question stem describes a typical presentation of BPH in an older man. Tamsulosin is an alpha-1 adrenergic receptor blocker that relaxes smooth muscle in the prostate and bladder neck to improve urine flow. The choices describe different intracellular signaling pathways. To answer the question, we need to know which of these pathways is affected by blocking alpha-1 adrenergic receptors. Alpha-1 receptors signal through phospholipase C, which produces IP3 and diacylglycerol, leading to activation of protein kinase C. Therefore, blocking alpha-1 receptors would decrease this signaling pathway.D: Decreased activity of phospholipase C 