<prompt> Please answer with one of the option in the bracket. Write reasoning in between . Write answer in between .Q:A 28-year-old man presents to his primary care provider complaining of intermittent stomach pain, non-bloody diarrhea, and weight loss for the last 3 months. He has occasional abdominal pain and fever. This condition makes studying difficult. He has tried omeprazole and dietary changes with no improvement. Past medical history is significant for occasional pain in the wrists and knees for several years. He takes ibuprofen for pain relief. His temperature is 38C 100.4F. On mental status examination, short-term memory is impaired. Attention and concentration are reduced. Examination shows no abnormalities or tenderness of the wrists or knees. There are no abnormalities on heart and lung examinations. Abdominal examination is normal. Upper endoscopy shows normal stomach mucosa but in the duodenum, there is pale yellow mucosa with erythema and ulcerations. Biopsies show infiltration of the lamina propria with periodic acid-Schiff PAS-positive macrophages. Which of the following best explains these findings?? A: Celiac disease, B: Crohns disease, C: Giardia lamblia infection, D: Whipples disease, E: Wilsons disease,  <response>: This is a clinical vignette describing a 28-year-old man with intermittent abdominal pain, diarrhea, weight loss, fever, and cognitive impairment. Key findings include duodenal inflammation and ulceration on endoscopy, with PAS-positive macrophages on biopsy. The differential diagnosis includes:Celiac disease - causes villous atrophy in the small intestine, leading to malabsorption. Biopsies would show intraepithelial lymphocytosis, crypt hyperplasia, and villous blunting. Crohns disease - causes transmural inflammation anywhere in the GI tract. Biopsies would show non-caseating granulomas.Giardia lamblia - protozoal infection causing watery diarrhea. Trophozoites or cysts would be seen on stool microscopy or duodenal biopsy.Whipples disease - rare infection caused by Tropheryma whipplei. Characteristic foamy macrophages with PAS-positive inclusions would be seen.Wilsons disease - autosomal recessive disorder of copper metabolism. Would see liver disease and Kayser-Fleischer rings on eye exam.The PAS-positive macrophages on biopsy are most consistent with Whipples disease. The other choices do not explain the biopsy findings.D: Whipples disease 