<prompt> Please answer with one of the option in the bracket. Write reasoning in between . Write answer in between .Q:A previously healthy 29-year-old African-American male comes to the physician with a 2-week history of progressive fatigue and shortness of breath on exertion. Last week he noticed that his eyes were gradually turning yellow and his urine was dark. He has a family history of type II diabetes. He denies changes in urinary frequency, dysuria, or nocturia. His temperature is 37C 98.6 F, blood pressure is 12080 mmHg, and heart rate is 80min. Examination shows pale conjunctivae, splenomegaly, and jaundice. There is no lymphadenopathy. Laboratory studies show:Hematocrit 19.5Hemoglobin 6.5 gdLWBC count 11,000mm3Platelet count 300,000mm3Reticulocyte count 8SerumTotal bilirubin 6 mgdLDirect bilirubin 1.0 mgdLUrea nitrogen 9 mgdLCreatinine 1 mgdLLactate dehydrogenase 365 ULPeripheral blood smear shows gross polychromasia with nucleated red blood cells and spherocytes. Direct Coombs test is positive. Which of the following is the most likely diagnosis?? A: Hereditary spherocytosis, B: Paroxysmal nocturnal hemoglobinuria, C: Alpha thalassemia, D: Spur cell hemolytic anemia, E: Autoimmune hemolytic anemian,  <response>: Based on the information provided in the question stem, the key findings are:- 29-year-old African-American male with 2-week history of fatigue, shortness of breath, jaundice, and dark urine- Physical exam shows pale conjunctivae, splenomegaly, and jaundice- Lab studies show anemia, reticulocytosis, elevated bilirubin with predominant direct fraction, elevated LDH- Peripheral smear shows polychromasia, nucleated RBCs, spherocytes- Positive direct Coombs testThe progressive jaundice, anemia, reticulocytosis, spherocytes, and positive direct Coombs test point towards a diagnosis of autoimmune hemolytic anemia. The other options can be ruled out based on the clinical and lab findings.E: Autoimmune hemolytic anemia 