<prompt> Please answer with one of the option in the bracket. Write reasoning in between . Write answer in between .Q:A 49-year-old man is brought to the emergency department after being discovered unconscious in a field near the county fair. Several empty bottles of vodka were found near him. On arrival, he is mumbling incoherently. He appears malodorous and disheveled. Serum studies show:Na 150 mEqLK 3.3 mEqLCl- 115 mEqLHCO3- 13 mEqLUrea nitrogen 30 mgdLGlucose 75 mgdLCreatinine 1.4 mgdLLactic acid 6 mmolL N 2Which of the following changes to enzyme activity best explains this patients laboratory findings?? A: Decreased activity of glucose-6-phosphate dehydrogenase, B: Increased activity of α-ketoglutarate dehydrogenase, C: Increased activity of phenylalanine hydroxylase, D: Decreased activity of phosphofructokinase-2, E: Decreased activity of pyruvate dehydrogenase,  <response>: Based on the patients history of alcohol abuse and unconscious state, this appears to be a case of alcoholic ketoacidosis. The lab findings of an elevated anion gap metabolic acidosis, with increased lactate, normal glucose, and no major electrolyte imbalances point towards impaired metabolism of pyruvate and a buildup of lactate. Of the choices given, a decrease in the activity of pyruvate dehydrogenase, which converts pyruvate to acetyl CoA and allows entry into the citric acid cycle, best explains the patients lactate accumulation and ketoacidosis.E: Decreased activity of pyruvate dehydrogenase 