<prompt> Please answer with one of the option in the bracket. Write reasoning in between . Write answer in between .Q:A 33-year-old man with recently diagnosed testicular cancer visits his oncologist to discuss the treatment plan. His left testicle was removed after a thorough workup of a lump. A pelvic CT showed no enlarged lymph nodes and a simple orchiectomy and pelvic lymph node dissection was completed. The final diagnosis was stage IB non-seminoma testicular cancer pT2N0Mna. A combination of different chemotherapeutic medications is recommended including bleomycin, etoposide, and cisplatin. Each of the antineoplastic drugs has a different mechanism of action; each drug targets cancer cells at a specific phase in the cell cycle and works by inhibiting a major cellular process. Which of the following enzymes would be affected by bleomycin?? A: DNA polymerase β, B: DNA polymerase III, C: Thymidylate synthase, D: Ribonucleotide reductase, E: Dihydrofolate reductase,  <response>: This is a question about the mechanism of action of the chemotherapy drug bleomycin for treating testicular cancer. The key information in the question stem is that bleomycin is recommended as part of combination chemotherapy for stage IB non-seminoma testicular cancer. The question asks which enzyme is affected by bleomycin. To answer this, we need to know the specific mechanism of action of bleomycin. Bleomycin causes DNA strand breaks by binding to DNA and oxidizing it. This disrupts DNA synthesis and causes apoptosis of cancer cells. So the enzyme that is directly affected by bleomycin is DNA polymerase, as bleomycin-induced DNA strand breaks inhibit DNA synthesis.A: DNA polymerase β 