<prompt> Please answer with one of the option in the bracket. Write reasoning in between . Write answer in between .Q:A 52-year-old woman presents with fatigue and pain of the proximal interphalangeal and metacarpophalangeal joints for the past 6 months. She also has knee and wrist pain that has been present for the past 2 months, with morning stiffness that improves over the course of the day. Physical examination is significant for subcutaneous nodules. Laboratory tests are significant for the following:Hemoglobin 12.5 gdLRed blood cell count 4.9 x 106μLWhite blood cell count 5,000mm3Platelet count 180,000mm3Coombs test NegativeC-reactive peptide CRP ElevatedErythrocyte sedimentation rate ESR NegativeAnti-cyclic citrullinated peptide antibody anti-CCP antibody Moderately positiveAnti-nuclear antibody ANA NegativeRheumatoid factor RF NegativeWhat is the most likely human leukocyte antigen HLA subtype associated with this disease?? A: HLA-DR4, B: HLA-DR2, C: HLA-DR5, D: HLA-DQ2, E: HLA-B27,  <response>: This question describes a patient with symptoms of joint pain, morning stiffness, and subcutaneous nodules, along with laboratory findings of anemia, leukopenia, thrombocytopenia, elevated CRP, and positive anti-CCP antibody. This presentation is most consistent with rheumatoid arthritis. Rheumatoid arthritis is strongly associated with the HLA-DR4 subtype.A: HLA-DR4 