<prompt> Please answer with one of the option in the bracket. Write reasoning in between . Write answer in between .Q:A 2-year-old girl presents to the pediatrician with an itchy rash. Her mother reports that she has had a crusty rash on the face and bilateral upper extremities intermittently for the past 2 months. The childs past medical history is notable for 3 similar episodes of severely itchy rashes since birth. She has also had 2 non-inflamed abscesses on her arms over the past year. Her temperature is 98.9F 37.2C, blood pressure is 10868 mmHg, pulse is 94min, and respirations are 18min. On exam, she appears uncomfortable and is constantly itching her face and arms. There is an eczematous rash on the face and bilateral upper extremities. Her face has thickened skin with a wide-set nose. This patients condition is most likely caused by a mutation in which of the following genes?? A: Adenosine deaminase, B: IL-12 receptor, C: LYST, D: STAT3, E: WAS,  <response>: This is a clinical vignette describing a 2-year-old girl with a history of recurrent itchy rashes and abscesses since birth. She has thickened facial skin and a wide-set nose. This presentation is most consistent with Jobs syndrome, also known as hyper-IgE syndrome. The key features are recurrent skin and lung infections, eczema, elevated IgE levels, and characteristic facies. Jobs syndrome is caused by mutations in STAT3.D: STAT3 