<prompt> Please answer with one of the option in the bracket. Write reasoning in between . Write answer in between .Q:A 65-year-old man with no significant medical history begins to have memory loss and personality changes. Rapidly, over the next few months his symptoms increase in severity. He experiences a rapid mental deterioration associated with sudden, jerking movements, particularly in response to being startled. He has gait disturbances as well. Eventually, he lapses into a coma and dies approximately ten months after the onset of symptoms. Which of the following would most likely be seen on autopsy of the brain in this patient?? A: A, B: B, C: C, D: D, E: E,  <response>: This question describes a patient with rapidly progressive dementia, myoclonus, and gait disturbances over a 10 month period before lapsing into a coma and dying. This clinical presentation is most consistent with Creutzfeldt-Jakob disease CJD, a rapidly progressive transmissible spongiform encephalopathy. On autopsy of CJD brains, typical findings include spongiform changes in the cerebral cortex and subcortical gray matter, neuronal loss, gliosis, and prion protein deposits.C: C 