<prompt> Please answer with one of the option in the bracket. Write reasoning in between . Write answer in between .Q:A 22-year-old woman presents with progressive hearing loss for the past 4 months. She says that she isnt hearing high frequency sounds like she used to, especially in large rooms. Her past medical history shows significant bilateral lens dislocations 6 months ago. Family history reveals that her mother had chronic hematuria and her grandfather suffered from corneal dystrophy and died from renal failure at age 51. The vital signs include: blood pressure 14595 mm Hg, pulse 78min, and respiratory rate 19min. On physical examination, the patient has mild to moderate bilateral sensorineural high-frequency hearing loss. A slit-lamp examination is shown in the exhibit see image. The remainder of the exam is unremarkable. Laboratory findings are significant for microscopic hematuria. Which of the following tests would most likely confirm the diagnosis in this patient?? A: Renal biopsy, B: Skin biopsy, C: Urinary creatinine 24-hour, D: Upright KUB radiograph, E: Renal ultrasound,  <response>: This is a clinical case scenario involving a 22-year-old woman with progressive high-frequency hearing loss, history of lens dislocations, family history of hematuria and renal failure, hypertension, microscopic hematuria on urinalysis, and slit lamp findings concerning for ectopia lentis. The key findings are the young age of onset, association of hearing loss and lens dislocations, family history, and hematuria, which are classic for Alport syndrome. Alport syndrome is caused by genetic mutations affecting type IV collagen, leading to basement membrane defects in the glomerulus, eye, and inner ear. The diagnosis is typically confirmed by skin biopsy showing absent or abnormal alpha-5 chains of type IV collagen. Renal biopsy could confirm the diagnosis but carries more risk. Creatinine, KUB, and renal ultrasound would not confirm the diagnosis.B: Skin biopsy 