<prompt> Please answer with one of the option in the bracket. Write reasoning in between . Write answer in between .Q:A 61-year-old woman who recently emigrated from India comes to the physician because of a 2-month history of fever, fatigue, night sweats, and a productive cough. She has had a 5-kg 11-lb weight loss during this period. She has a history of type 2 diabetes mellitus and poorly controlled asthma. She has had multiple asthma exacerbations in the past year that were treated with glucocorticoids. An x-ray of the chest shows a cavitary lesion of the posterior apical segment of the left upper lobe with consolidation of the surrounding parenchyma. The pathogen identified on sputum culture is found to be resistant to multiple drugs, including streptomycin. Which of the following mechanisms is most likely involved in bacterial resistance to this drug?? A: Alteration in the sequence of gyrA genes, B: Inhibition of bacterial synthesis of RNA, C: Alteration in 30S ribosomal subunit, D: Upregulation of mycolic acid synthesis, E: Upregulation of arabinosyl transferase production,  <response>: This is a question about the mechanism of bacterial resistance to the antibiotic streptomycin. The patient is a 61-year-old woman who recently emigrated from India and has symptoms and imaging findings consistent with tuberculosis. Her sputum culture grew a pathogen resistant to multiple drugs including streptomycin. The question asks which mechanism is most likely involved in resistance to streptomycin specifically. Streptomycin works by binding to the 30S subunit of bacterial ribosomes, inhibiting protein synthesis. Bacterial resistance is most commonly caused by mutations in the rpsL and rrs genes encoding the 30S ribosomal subunit, reducing streptomycins binding affinity. Choices A and D relate to mechanisms of resistance to other antibiotics like fluoroquinolones and isoniazid. Choice B describes streptomycins mechanism of action rather than resistance. Choice E involves resistance to another tuberculosis drug. Only choice C describes the most common mechanism of resistance to streptomycin itself.C: Alteration in 30S ribosomal subunit 