<prompt> Please answer with one of the option in the bracket. Write reasoning in between . Write answer in between .Q:A 35-year-old Caucasian female presents with anemia, malaise, bloating, and diarrhea. Past genetic testing revealed that this patient carries the HLA-DQ2 allele. The physician suspects that the patients presentation is dietary in cause. Which of the following findings would definitively confirm this diagnosis?? A: CT scan showing inflammation of the small bowel wall, B: Biopsy of the duodenum showing atrophy and blunting of villi, C: Biopsy of the colon showing epithelial cell apoptosis, D: Liver biopsy showing apoptosis of hepatocytes, E: Esophageal endoscopy showing lower esophageal metaplasia,  <response>: This is a clinical vignette describing a patient with symptoms of anemia, malaise, bloating, and diarrhea. The patient is known to carry the HLA-DQ2 allele, which predisposes to celiac disease. The physician suspects the symptoms may be dietary in origin. The question asks which of the following findings would definitively confirm the diagnosis of celiac disease. Choice A describes inflammation of the small bowel seen on CT scan. This is nonspecific and would not definitively confirm celiac disease.Choice B describes biopsy findings of villous atrophy and blunting in the duodenum. This is pathognomonic for celiac disease and would definitively confirm the diagnosis. Choice C describes colonic biopsy findings. This would not be relevant for diagnosing small bowel disease like celiac. Choice D describes liver biopsy findings. While celiac can cause liver changes, this alone would not confirm the diagnosis. Choice E describes esophageal changes. This is not specific for celiac disease.Therefore, choice B which describes the classic biopsy findings of villous atrophy in the duodenum is the answer that would definitively confirm the diagnosis of celiac disease.B: Biopsy of the duodenum showing atrophy and blunting of villi 