<prompt> Please answer with one of the option in the bracket. Write reasoning in between . Write answer in between .Q:A 55-year-old woman sees her family doctor for a follow-up appointment to discuss her imaging studies. She previously presented with chest pain and shortness of breath for the past 2 months. Her CT scan shows a 3.5 cm mass in the lower lobe of her right lung. The mass has irregular borders. Saddlehilar lymph nodes are enlarged. No distant metastases are identified with PET imaging. The patient has been a smoker for over 35 years 1.5 packs per day, but she has recently quit. This patient is referred to the Pulmonary Diseases Center. What is the most effective step in appropriately managing her case?? A: Tissue biopsy, B: Sputum cytology, C: CT scan in 3 months, D: Paclitaxel, E: Radiotherapy,  <response>: This is a patient with a likely lung cancer diagnosis based on her smoking history, symptoms, and imaging findings of a mass in the lung with irregular borders and enlarged lymph nodes. The next step is to obtain a tissue diagnosis to confirm malignancy and determine the specific type of lung cancer. Sputum cytology has low sensitivity and cannot reliably diagnose lung cancer. Repeating CT scan in 3 months delays diagnosis and treatment. Paclitaxel and radiotherapy are treatment options that should only be considered after tissue diagnosis confirms cancer. A: Tissue biopsy 