<prompt> Please answer with one of the option in the bracket. Write reasoning in between . Write answer in between .Q:A 46-year-old obese man comes to the emergency room because of paresthesias in his feet and a hypopigmented skin lesion on his knee that he first noticed 6 weeks ago. He has also had fever, fatigue, and malaise for the last week. He has a history of chronic autoimmune thyroiditis for which he takes levothyroxine. He immigrated from Indonesia 3 years ago to join his family in the United States. His temperature is 38.7C 101.7F and blood pressure is 12284 mm Hg. Physical exam shows a well-defined hypopigmented skin lesion approximately 3 cm in diameter over the anterior aspect of the right knee. The area has no hair growth and remains dry although he is diaphoretic. There is diminished sensation to light touch and pinprick in the skin lesion when compared to surrounding skin. There is reduced light touch sensation in the big toes bilaterally. After obtaining a skin biopsy of the lesion to confirm the diagnosis, which of the following is the most appropriate initial pharmacotherapy?? A: Oral hydroxychloroquine, B: Topical fluconazole, C: Topical betamethasone, D: Intravenous amphotericin, E: Oral rifampicin and dapsone,  <response>: This is a clinical vignette describing a patient with fever, fatigue, malaise, paresthesias in the feet, and a hypopigmented skin lesion on the knee. The key findings are:- 46-year-old obese man - Paresthesias in feet- Hypopigmented skin lesion on knee- Fever, fatigue, malaise for 1 week- History of chronic autoimmune thyroiditis on levothyroxine - Immigrated from Indonesia 3 years ago- Temperature 38.7C - Blood pressure 12284 mmHg- Well-defined hypopigmented lesion 3cm on right knee anterior aspect, no hair growth, remains dry- Diminished sensation in skin lesion compared to surrounding skin- Reduced light touch sensation in big toes bilaterally- Skin biopsy done to confirm diagnosisThis presentation is most consistent with leprosy given the skin lesion with diminished sensation, paresthesias, and history of living in an endemic area. The goal is to start appropriate antimicrobial therapy.E: Oral rifampicin and dapsone 