<prompt> Please answer with one of the option in the bracket. Write reasoning in between . Write answer in between .Q:A 56-year-old female presents for initial evaluation by a rheumatologist with a chief complaint of back and joint pain. She says that she has been having mild pain for years, but that the pain has become worse over the course of the last 6 months. She clarifies that the pain is most severe in the mornings just after waking up but seems to improve throughout the day. She also notices that her mouth feels dry and she has difficulty eating dry food such as crackers. Finally, she has the sensation of having bits of sand in her eyes. She denies any past medical history or medication use. Serology for which of the following would most likely be positive in this patient?? A: Anti-smooth muscle antibody, B: Anti-centromere antibody, C: Anti-cyclic citrullinated peptide CCP antibody, D: Anti-Jo1 and anti-Mi2 antibodies, E: Anti-Ro and anti-La antibodies,  <response>: This patient is presenting with symptoms suggestive of an autoimmune rheumatologic disease. The key features are morning stiffness, dry mouth, difficulty eating dry foods, and dry eyes. This constellation of symptoms is most consistent with Sjogrens syndrome, an autoimmune disease characterized by lymphocytic infiltration and dysfunction of the salivary and lacrimal glands. Sjogrens syndrome is associated with several autoantibodies, most commonly anti-Ro and anti-La antibodies. Anti-smooth muscle, anti-centromere, and anti-CCP antibodies would be more consistent with other rheumatologic diseases like systemic sclerosis, limited systemic sclerosis, and rheumatoid arthritis respectively. Anti-Jo1 and anti-Mi2 antibodies are associated with myositis.Therefore, the serology most likely to be positive in this patient with symptoms of Sjogrens syndrome would be anti-Ro and anti-La antibodies.E: Anti-Ro and anti-La antibodies 