<prompt> Please answer with one of the option in the bracket. Write reasoning in between . Write answer in between .Q:A 65-year-old African-American man presents to your office with dysphagia. He reports that he has found it progressively more difficult to swallow food over the past year. At the time of presentation, he is able to eat only soup. Social history is significant for asbestos exposure, multiple daily drinks of hard alcohol, and a 70 pack-year smoking history. What would you most expect to see on an esophageal biopsy of this patient?? A: Keratin nests and pearls, B: Ferruginous bodies, C: Glandular metaplasia, D: Mucosal abrasions, E: Esophageal varices,  <response>: This is a clinical vignette describing a 65-year-old African American man with progressive dysphagia over 1 year who has a history of asbestos exposure, alcohol use, and heavy smoking. The question asks what would most likely be seen on esophageal biopsy in this patient. Based on the patients demographics and risk factors, the most likely diagnosis is esophageal squamous cell carcinoma. Asbestos exposure and smoking are major risk factors for this cancer. Alcohol use also increases risk. Dysphagia is a common presenting symptom as the tumor obstructs the esophageal lumen. Choice A describes findings seen in esophageal squamous cell carcinoma - keratin pearls and nests. Choices B-E describe findings unrelated to esophageal cancer in this clinical scenario. Ferruginous bodies choice B can be seen with asbestos exposure but not in the esophagus. Glandular metaplasia choice C can be seen with reflux esophagitis. Mucosal abrasions choice D can occur with food impaction. Esophageal varices choice E occur with portal hypertension, which is not described here.A: Keratin nests and pearls 