<prompt> Please answer with one of the option in the bracket. Write reasoning in between . Write answer in between .Q:A 3-year-old boy presents to the pediatrics clinic for follow-up. He has a history of severe pyogenic infections since birth. Further workup revealed a condition caused by a defect in CD40 ligand expressed on helper T cells. This congenital immunodeficiency has resulted in an inability to class switch and a poor specific antibody response to immunizations. Which of the following best characterizes this patients immunoglobulin profile?? A: Increased IgE, B: Decreased IgA, C: Decreased Interferon gamma, D: Increased IgE and IgA; and decreased IgM, E: Increased IgM; decreased IgG, IgA, and IgE,  <response>: This is a question about a patient with a history of severe pyogenic infections since birth. The patient has a defect in CD40 ligand expressed on helper T cells, resulting in an inability to class switch and poor specific antibody response to immunizations. Based on the information provided, this patient likely has X-linked hyper IgM syndrome. This is caused by a mutation in the CD40LG gene on the X chromosome, leading to defective CD40 ligand on T cells. The key immunoglobulin abnormalities in X-linked hyper IgM syndrome are:- Increased IgM- Decreased IgG, IgA, IgESo out of the answer choices, E matches the expected immunoglobulin profile in this disorder.E: Increased IgM; decreased IgG, IgA, and IgE 