<prompt> Please answer with one of the option in the bracket. Write reasoning in between . Write answer in between .Q:A 40-year-old man presents to the office with complaints of fatigue and difficulty breathing for the past few weeks. He also complains of early morning stiffness of his metatarsophalangeal and metacarpophalangeal joints on both sides that lasts for 2 hours. He feels better only after a warm water tub bath every day in the morning. He denies noticing any kind of rash on his body. He has been working in the shipbuilding industry for 20 years. He loves skin tanning and hunting in summer. He smokes 2 packs of cigarettes every day and has been doing so for the past 15 years. His pulmonary function test shows reduced forced expiratory volume in 1 second FEV1forced vital capacity FVC ratio with a reduction of both FEV1 and FEV1 and decreased diffusing capacity of the lungs for carbon monoxide DLCO. His chest X-ray shows multiple nodules with calcification. Which of the following antibodies will most likely be present in this patient that is very specific to the condition he has?? A: Anti-CCP, B: Anti-Scl 70, C: Anti-Ro, D: Anti-ds-DNA, E: Anti-Jo1,  <response>: This is a clinical vignette describing a 40-year-old man with symptoms of morning joint stiffness, fatigue, and breathing difficulties. The history provides clues pointing towards a diagnosis of rheumatoid arthritis with pulmonary involvement: morning stiffness of small joints, fatigue, reduced lung function on PFTs, and lung nodules on CXR. The question asks which antibody is most specific to this patients likely diagnosis. Anti-CCP antibodies are highly specific for rheumatoid arthritis. Anti-Scl-70 is associated with systemic sclerosis, Anti-Ro with Sjogrens syndrome, Anti-dsDNA with systemic lupus erythematosus, and Anti-Jo1 with polymyositisdermatomyositis. Therefore, the presence of Anti-CCP antibodies would be most consistent with this patients presentation.A: Anti-CCP 