<prompt> Please answer with one of the option in the bracket. Write reasoning in between . Write answer in between .Q:A pharmaceutical company conducts a randomized clinical trial in an attempt to show that their new anticoagulant drug, Aclotsaban, prevents more thrombotic events following total knee arthroplasty than the current standard of care. However, a significant number of patients are lost to follow-up or fail to complete treatment according to the study arm to which they were assigned. Despite this, the results for the patients who completed the course of Aclotsaban are encouraging. Which of the following techniques is most appropriate to use in order to attempt to prove the superiority of Aclotsaban?? A: Per-protocol analysis, B: Intention-to-treat analysis, C: As-treated analysis, D: Sub-group analysis, E: Non-inferiority analysis,  <response>: This is a question about the appropriate statistical analysis technique to use in a randomized clinical trial where there is a significant loss to follow-up. The key factors are:- It is a randomized trial comparing a new drug Aclotsaban to standard of care- There is a significant loss to follow-up and failure to complete assigned treatment- The results for those completing Aclotsaban are encouragingThe analysis needs to account for the loss to follow-up and non-adherence to assigned treatment. Per-protocol analysis only includes patients who completed treatment as assigned. As-treated analysis groups patients based on the treatment they actually received. Subgroup analysis looks at outcomes in a subset of patients. Non-inferiority analysis aims to show the new drug is not clinically worse than standard care. Given the randomized design and the need to account for loss to follow-up and nonadherence, intention-to-treat analysis is most appropriate here.B: Intention-to-treat analysis 