<prompt> Please answer with one of the option in the bracket. Write reasoning in between . Write answer in between .Q:A 29-year-old woman presents to her gynecologist for a routine check-up. She is sexually active with multiple partners and intermittently uses condoms for contraception. She denies vaginal discharge, burning, itching, or rashes in her inguinal region. Pelvic examination is normal. Results from a routine pap smear are shown. The cellular changes seen are attributable to which of the following factors?? A: Inhibition of p53, B: Activation p53, C: Activation of Rb, D: Activation of K-Ras, E: Inhibition of p16,  <response>: This is a question about cervical cytology and identifying cellular changes seen on a pap smear. The patient is a sexually active 29 year old woman with multiple partners and inconsistent condom use. She has no symptoms on exam but her pap smear shows abnormal cellular changes. The choices list various tumor suppressors and oncogenes. Cervical dysplasia and cervical cancer are often caused by HPV infection. HPV can inactivate the p53 and pRb tumor suppressor pathways. Therefore, the cellular changes seen are likely attributable to inhibition of p53.A: Inhibition of p53 