<prompt> Please answer with one of the option in the bracket. Write reasoning in between . Write answer in between .Q:A researcher is investigating compounds that modulate the cell cycle as possible chemotherapeutic agents against peripheral T-cell lymphoma. The researcher discovers a group of natural compounds with inhibitory activity against histone deacetylases, a class of enzymes that remove acetyl groups from the lysine residues of histones. A histone deacetylase inhibitor most likely causes which of the following?? A: Tighter coiling of DNA, B: Relaxation of DNA coiling, C: Suppression of gene transcription, D: Prevention of DNA strand reannealing, E: Increased heterochromatin formation,  <response>: This question is asking about the effect of histone deacetylase inhibitors on DNA structure and gene expression. Histone deacetylases remove acetyl groups from histones, causing the histones to wrap DNA more tightly. Inhibiting histone deacetylases would therefore have the opposite effect - it would relax DNA coiling and make DNA more accessible for transcription. Choices A and E relate to tighter coilingcondensation of DNA, so they can be eliminated. Choice C is incorrect because inhibiting histone deacetylases would increase, not suppress, gene transcription. Choice D relates to DNA replication, not transcription, so it is irrelevant here. Therefore, the correct answer should be choice B, which states that histone deacetylase inhibitors cause relaxation of DNA coiling.B: Relaxation of DNA coiling 