<prompt> Please answer with one of the option in the bracket. Write reasoning in between . Write answer in between .Q:A 43-year-old woman comes to the physician with a 2-week history of new pruritic plaques on the scalp and extensor surfaces of the elbows and knees. Ten years ago, she was diagnosed with psoriasis. Her only medication is topical calcipotriene. Physical examination shows well-demarcated, symmetrical, erythematous plaques with silvery scale. There is pitting of the nails on all fingers. Therapy with a high-potency topical medication that inhibits NF-κB and phospholipase A2 is begun. Long-term use of this agent is most likely to result in which of the following?? A: Dysplastic nevi, B: Nonblanchable pinpoint macules, C: Decreased sebum production, D: Dermal collagen loss, E: Hair growth on upper lip,  <response>: This is a clinical vignette describing a 43-year-old woman with a history of psoriasis presenting with new pruritic plaques consistent with psoriasis. She is started on a high-potency topical medication that inhibits NF-kB and phospholipase A2, likely a topical corticosteroid. The question asks about the long-term side effect of using this medication. Choice A Dysplastic nevi is incorrect, as this is not a side effect of topical corticosteroids. Choice B Nonblanchable pinpoint macules describes telangiectasias which can occur with long-term use of topical corticosteroids.Choice C Decreased sebum production is incorrect, as topical corticosteroids do not affect sebum production.Choice D Dermal collagen loss is correct, as atrophy and dermal collagen loss are known side effects of long-term topical corticosteroid use. Choice E Hair growth on upper lip is incorrect, as this is not a side effect of topical corticosteroids.Therefore, the answer is choice D Dermal collagen loss as this is the long-term side effect of using high-potency topical corticosteroids.D: Dermal collagen loss 