<prompt> Please answer with one of the option in the bracket. Write reasoning in between . Write answer in between .Q:A 2-month-old baby boy and his mother present to his pediatrician for vaccination as per the immunization schedule. His mother denies any active complaints but mentions that he has not smiled yet. The boy was born at 39 weeks gestation via spontaneous vaginal delivery. His mother received minimal prenatal care. On physical examination, his vitals are stable, but a general examination shows the presence of generalized hypotonia. His face is characterized by upwardly slanting palpebral fissures, small dysplastic ears, and a flat face. His little fingers are short, with clinodactyly, and both palms have single palmar creases. The results of a karyotype are shown in the image. If this infant has also inherited a mutation in the GATA1 gene, for which of the following conditions is he most likely to be at increased risk?? A: Acute megakaryoblastic leukemia, B: Celiac disease, C: Congenital hypothyroidism, D: Congenital cataracts, E: Endocardial cushion defect,  <response>: This is a clinical vignette describing a 2-month-old baby boy with physical exam findings suggestive of Down syndrome, including hypotonia, upward slanting palpebral fissures, small dysplastic ears, flat facies, short fifth fingers with clinodactyly, and single palmar creases. The karyotype confirms trisomy 21. The question asks which condition the infant would be at increased risk for if he also had a mutation in the GATA1 gene. GATA1 mutations are associated with a predisposition to transient myeloproliferative disorder and acute megakaryoblastic leukemia in children with Down syndrome. Of the answer choices, acute megakaryoblastic leukemia is most closely associated with GATA1 mutations in Down syndrome. The other answers are not known to be associated with GATA1 mutations.A: Acute megakaryoblastic leukemia 