<prompt> Please answer with one of the option in the bracket. Write reasoning in between . Write answer in between .Q:A 38-year-old man presents to his primary care practitioner for 2 months of rectal bleeding. He also reports occasional diarrhea and abdominal pain. His family history is relevant for his father and uncle, who died from complications of colorectal cancer. Colonoscopy shows more than 10 colorectal adenomas. Which of the following genes is most likely affected in this patient?? A: RAS, B: TP53, C: APC, D: hMLH1, E: PPAR,  <response>: This is a patient with a family history of colorectal cancer who is presenting with symptoms of rectal bleeding, diarrhea, and abdominal pain. He has been found to have more than 10 colorectal adenomas on colonoscopy. This clinical picture is most consistent with familial adenomatous polyposis FAP, an autosomal dominant condition caused by mutations in the APC gene. FAP leads to the development of hundreds to thousands of colorectal adenomas beginning in adolescence or early adulthood, with nearly 100 lifetime risk of colorectal cancer if untreated. The other gene choices listed are not associated with FAP. RAS mutations lead to sporadic colorectal cancers. TP53 mutations are seen in Li-Fraumeni syndrome. hMLH1 mutations cause Lynch syndrome. PPAR mutations do not have a clear association with colorectal polyps or cancer. Therefore, the APC gene is most likely affected in this patient.C: APC 