<prompt> Please answer with one of the option in the bracket. Write reasoning in between . Write answer in between .Q:A 64-year-old man comes to the emergency department complaining of fatigue and abdominal distension. He has a remote history of intravenous drug use. Vital signs include a normal temperature, blood pressure of 12080 mm Hg, and a pulse of 75min. Physical examination reveals jaundice and a firm liver. Abdominal ultrasonography shows liver surface nodularity, moderate splenomegaly, and increased diameter of the portal vein. Complete blood count of the patient is shown:Hemoglobin 14 gdLMean corpuscular volume 90μm3Mean corpuscular hemoglobin 30 pgcellMean corpuscular hemoglobin concentration 34Leukocyte count 7,000mm3Platelet count 50,000mm3Which of the following best represents the mechanism of low platelet count in this patient?? A: Bone marrow-based disorder, B: Platelet sequestration, C: Increased platelet clearance, D: Genetic disorder, E: Dilutional effect,  <response>: This is a medical question about a patient with fatigue, abdominal distension, history of IV drug use, jaundice, firm liver, nodular liver surface, splenomegaly, enlarged portal vein, anemia, and thrombocytopenia. The key finding is thrombocytopenia low platelet count in a patient with chronic liver disease. The enlarged spleen and nodular liver surface suggest cirrhosis, which can lead to hypersplenism and subsequent platelet sequestration in the spleen. This results in low circulating platelet levels.The other options can be ruled out:- Bone marrow disorder is unlikely with otherwise normal blood counts. - Increased platelet clearance could occur but is less likely than splenic sequestration in this clinical scenario.- There is no evidence for a genetic or dilutional cause of the thrombocytopenia.B: Platelet sequestration 