<prompt> Please answer with one of the option in the bracket. Write reasoning in between . Write answer in between .Q:A previously healthy 48-year-old man comes to the physician because of a 2-month history of weight loss and yellowing of the skin. He works as a farmer and cultivates soybean and corn. He does not smoke, drink alcohol, or use illicit drugs. His vital signs are within normal limits. Physical examination shows scleral icterus and tender hepatomegaly. Ultrasonography of the abdomen shows a 5-cm nodular lesion in the right lobe of the liver. Further evaluation of the lesion confirms hepatocellular carcinoma. The activity of which of the following enzymes most likely contributed to the pathogenesis of this patients condition?? A: Peroxisomal catalases, B: Lysosomal serine proteases, C: Cytosolic cysteine proteases, D: Cytochrome P450 monooxygenases, E: Nuclear glycosylases,  <response>: This is a question about hepatocellular carcinoma in a 48-year-old male farmer with no significant medical history. Key findings include weight loss, jaundice, hepatomegaly, and a liver mass confirmed as HCC. This suggests a chronic liver disease as the underlying cause. The choices list various enzymes. The question asks which one most likely contributed to the pathogenesis. Farmers are at risk for exposure to aflatoxins from crops like corn and soybeans. Aflatoxins are metabolized by cytochrome P450 enzymes into carcinogenic intermediates. Therefore, cytochrome P450 monooxygenases are the most likely choice.Peroxisomal catalases, lysosomal proteases, and cytosolic proteases are less relevant. Glycosylases are involved in DNA repair rather than carcinogen metabolism.D: Cytochrome P450 monooxygenases 