<prompt> Please answer with one of the option in the bracket. Write reasoning in between . Write answer in between .Q:A 60-year-old man seeks evaluation at a medical office due to leg pain while walking. He says the pain starts in his buttocks and extends to his thighs and down to his calves. Previously, the pain resolved with rest, but the pain now persists in his feet, even during rest. His past medical history is significant for diabetes mellitus, hypertension, and cigarette smoking. The vital signs are within normal limits. The physical examination shows an atrophied leg with bilateral loss of hair. Which of the following is the most likely cause of this patients condition?? A: Decreased permeability of endothelium, B: Narrowing and calcification of vessels, C: Peripheral emboli formation, D: Thrombus formation, E: Weakening of vessel wall,  <response>: This is a patient with leg pain that starts in the buttocks and radiates down the legs, even at rest now. He has a history of diabetes, hypertension, and smoking. He has physical exam findings of atrophied legs with hair loss. This presentation is most consistent with peripheral arterial disease likely secondary to atherosclerosis from his risk factors. The pain at rest and abnormal exam indicate advanced disease with significant arterial occlusion. Of the choices, narrowing and calcification of vessels atherosclerosis is the most likely cause.B: Narrowing and calcification of vessels 