<prompt> Please answer with one of the option in the bracket. Write reasoning in between . Write answer in between .Q:A 43-year-old woman presents to your clinic for the evaluation of an abnormal skin lesion on her forearm. The patient is worried because her mother passed away from melanoma. You believe that the lesion warrants biopsy for further evaluation for possible melanoma. Your patient is concerned about her risk for malignant disease. What is the most important prognostic factor of melanoma?? A: S-100 tumor marker present, B: Evolution of lesion over time, C: Age at presentation, D: Depth of invasion of atypical cells, E: Level of irregularity of the borders,  <response>: This is a question asking about the most important prognostic factor for melanoma. The choices include tumor markers, evolution of the lesion over time, patient age, depth of invasion, and border irregularity. Of these, depth of invasion is the most important prognostic factor for melanoma. The deeper the invasion, the higher the risk of metastasis and mortality. Patient age and border irregularity are less reliable prognostic factors. S-100 is a tumor marker that can help with diagnosis but does not provide prognostic information. Evolution over time can indicate a concerning lesion but does not directly correlate with prognosis once a melanoma is diagnosed. D: Depth of invasion of atypical cells 