<prompt> Please answer with one of the option in the bracket. Write reasoning in between . Write answer in between .Q:A 24-year-old African American male with sickle cell disease has been followed by a hematologist since infancy. Two years ago, he was started on hydroxyurea for frequent pain crises but has not achieved good control. The addition of a Gardos channel blocking agent is being considered. What is the mechanism of action of this class of medications?? A: Prevents RBC dehydration by inhibiting K efflux, B: Increases production of hemoglobin F, C: Prevents dehydration of RBCs by inhibiting Ca2 efflux, D: Encourages alkalinization of the blood by facilitating HK antiporter activity, E: Increases water diffusion by increasing activity of aquaporin-1 receptors,  <response>: This is a question about the mechanism of action of Gardos channel blocking agents in sickle cell disease. Sickle cell disease is characterized by sickling of red blood cells leading to vaso-occlusion and hemolytic anemia. Gardos channel blocking agents work by preventing potassium efflux from red blood cells, which helps maintain red blood cell hydration and decreases sickling. The correct answer will describe this mechanism of preventing potassium efflux.A: Prevents RBC dehydration by inhibiting K efflux 