<prompt> Please answer with one of the option in the bracket. Write reasoning in between . Write answer in between .Q:A 42-year-old woman comes to the clinic with a complaint of a severely itchy and painful rash on her hands and legs for a day. On further questioning, she revealed that she loves nature and goes on trekking to the woods frequently. She just returned from a similar trip, 2 days ago. On physical examination, a prominent rash along with multiple blisters is noted on the ventral aspect of her right forearm. A photograph of the rash is shown. Which of the following is the most likely reaction that the patient is experiencing?? A: Type IV hypersensitivity reaction, B: Type III hypersensitivity reaction, C: Bullous pemphigoid, D: Type I hypersensitivity reaction, E: Type II hypersensitivity reaction,  <response>: This is a clinical vignette describing a 42-year-old woman with a sudden onset itchy and painful rash on her hands and legs. She has a history of frequent trekking in the woods. On exam she has a rash with blisters on her right forearm. Based on the acute onset after returning from the woods, this is most likely an allergic reaction from exposure to something in the environment during her recent trek. The rash and blisters localize the reaction to her skin. This presentation is most consistent with a type IV delayed hypersensitivity reaction. These reactions are mediated by T cells rather than antibodies. They occur 48-72 hours after exposure, consistent with the timing after her return from the woods. The rash and blisters represent the inflammatory response.Type I reactions involve IgE and occur rapidly after exposure. Type II is cytotoxic. Type III involves immune complex deposition. Bullous pemphigoid is an autoimmune blistering skin disorder. These are less likely based on the time course and clinical scenario described.A: Type IV hypersensitivity reaction 