<prompt> Please answer with one of the option in the bracket. Write reasoning in between . Write answer in between .Q:A 5-year-old girl is brought to her pediatrician for vaccinations and a physical. She is a generally healthy child with no thumb on her right hand and a shortened and deformed left thumb. She was born at 39 weeks gestation via spontaneous vaginal delivery and is up to date on all vaccines and meeting all developmental milestones. On physical examination her vital signs are stable. On auscultation of the heart, the pediatrician notes a wide fixed split in the second heart sound S2 and a medium-pitched systolic ejection murmur at the left sternal border. The murmur is not harsh in quality and is not accompanied by a thrill. Her echocardiogram confirms the diagnosis of acyanotic congenital heart defect with left-to-right shunt. Which of the following genetic syndromes is most consistent d with this girls congenital defects?? A: Alagille syndrome, B: DiGeorge syndrome, C: Holt-Oram syndrome, D: Marfan syndrome, E: Williams-Beuren syndrome,  <response>: This is a multiple choice question asking about the genetic syndrome most consistent with a 5-year-old girls congenital heart defect acyanotic with left-to-right shunt and limb abnormalities absent right thumb and shortened, deformed left thumb. The key findings in the stem are:- Congenital heart defect: acyanotic with left-to-right shunt - Limb abnormalities: absent right thumb and shortened, deformed left thumbGoing through the choices:- Alagille syndrome: Associated with cardiac defects but not limb abnormalities. Not consistent.- DiGeorge syndrome: Associated with conotruncal cardiac defects, not left-to-right shunts. Not consistent. - Holt-Oram syndrome: Associated with limb abnormalities radial ray defects and ASDVSD. Most consistent with the clinical findings.- Marfan syndrome: Associated with aortic abnormalities, not left-to-right shunts. Not consistent. - Williams-Beuren syndrome: Associated with supravalvular aortic stenosis, not left-to-right shunts. Not consistent.Based on this analysis, Holt-Oram syndrome is the most consistent with the clinical findings described.C: Holt-Oram syndrome 