<prompt> Please answer with one of the option in the bracket. Write reasoning in between . Write answer in between .Q:A 59-year-old man comes to the physician because of bilateral blurry vision and difficulty driving at night that has been worsening progressively over the past 5 months. He has hypertension, type 2 diabetes mellitus, and hyperlipidemia. His hemoglobin A1c concentration is 8.9 mgdL. A slit-lamp shows cloudy opacities of the lenses bilaterally. The patients eye condition is most likely due to increased activity of which of the following enzymes?? A: Galactokinase, B: Aldolase B, C: Glucokinase, D: Aldose reductase, E: Sorbitol dehydrogenase,  <response>: This is a clinical vignette describing a 59-year-old man with blurry vision and night blindness, as well as a history of hypertension, type 2 diabetes mellitus, and hyperlipidemia. His hemoglobin A1c is elevated at 8.9 mgdL, indicating poor control of his diabetes. On slit lamp exam, he has bilateral cataracts. The symptoms and exam findings are consistent with diabetic cataracts, a complication of uncontrolled diabetes. The cataracts are caused by accumulation of sorbitol in the lens of the eye due to increased activity of the aldose reductase enzyme. This enzyme converts glucose to sorbitol as part of the polyol pathway. In diabetes, elevated intracellular glucose leads to increased flux through this pathway and accumulation of sorbitol, which causes osmotic stress and lens opacity.Of the enzyme choices provided, increased activity of aldose reductase best explains this patients cataracts in the setting of poorly controlled diabetes.D: Aldose reductase 