<prompt> Please answer with one of the option in the bracket. Write reasoning in between . Write answer in between .Q:Which of the following events is likely to occur in the germinal center?? A: Development of early pro-B cells, B: Development of immature B cells, C: T-cell negative selection, D: Isotype switching, E: Formation of double-positive T cells,  <response>: This is a question asking about events that occur in the germinal center. The germinal center is a structure within lymph nodes and other secondary lymphoid organs where mature B cells proliferate, differentiate, and undergo antibody class switching. Choice A describes early B cell development, which occurs in the bone marrow, not in germinal centers. Choice B describes immature B cell development, which also occurs in the bone marrow.Choice C describes T cell development, which does not take place in germinal centers. Choice D describes isotype switching of antibodies, which does occur in germinal centers. Choice E describes T cell development, which does not occur in germinal centers.Based on this analysis, choice D Isotype switching is the event that is most likely to occur in the germinal center.D: Isotype switching 