<prompt> Please answer with one of the option in the bracket. Write reasoning in between . Write answer in between .Q:A 45-year-old gentleman comes to his primary care physician complaining of redness and foul-smelling discharge from his penis. The patient is not married and denies sexual activity. Upon further questioning, he denies trauma or any associated fevers or chills. After the initial work-up was found to be negative for sexually-transmitted diseases, a biopsy and imaging were ordered. The biopsy shows squamous cell carcinoma SCC. Which of the following is associated with a reduced risk of developing penile SCC?? A: Having frequent intercourse, B: Testing positive for HPV 16 or 18, C: Smoking, D: Circumcision, E: UV light treatments for psoriasis,  <response>: This is a question about risk factors for penile squamous cell carcinoma SCC. The patient is a 45-year-old man with penile SCC but no history of sexual activity or STDs. The question asks which factor is associated with reduced risk of penile SCC.Choice A about frequent intercourse is not relevant since the patient denies sexual activity. Choice B about HPV 1618 is a risk factor for penile SCC, not a protective factor. Choice C about smoking is a known risk factor. Choice D about circumcision is a protective factor against penile SCC. Choice E about UV light for psoriasis has not been associated with penile SCC risk.Therefore, the correct answer is choice D, circumcision, which is associated with reduced risk of penile SCC.D: Circumcision 