<prompt> Please answer with one of the option in the bracket. Write reasoning in between . Write answer in between .Q:A 42-year-old woman comes to the physician for a routine health maintenance examination. She is doing well. She is 168 cm 5 ft 6 in tall and weighs 75 kg 165 lb; BMI is 27 kgm2. Her BMI had previously been stable at 24 kgm2. The patient states that she has had decreased appetite over the past month. The patients change in appetite is most likely mediated by which of the following?? A: Increased hepatic somatomedin C secretion, B: Decreased hypothalamic neuropeptide Y, C: Potentiation of cholecystokinin, D: Increased fatty acid oxidation, E: Inhibition of proopiomelanocortin neurons,  <response>: This is a question about the physiological mechanisms that regulate appetite. The patient is a 42-year-old woman whose BMI has recently increased from a stable 24 kgm2 to 27 kgm2, along with decreased appetite over the past month. The hypothalamus plays a key role in regulating appetite by integrating signals about nutritional status and energy balance. Neuropeptide Y NPY is an orexigenic appetite-stimulating hormone secreted by the hypothalamus. A decrease in NPY would be expected to cause decreased appetite. Cholecystokinin CCK is a hormone released from the small intestine in response to fat and protein in chyme. CCK acts as a satiety signal to decrease appetite. Potentiation of CCK would also be expected to cause decreased appetite.Somatomedin C also called insulin-like growth factor 1 or IGF-1 is secreted by the liver in response to growth hormone. It does not have a direct role in regulating appetite. Increased fatty acid oxidation signals adequate energy supply to the body. This would be expected to increase, not decrease appetite. Proopiomelanocortin POMC neurons in the hypothalamus promote satiety by secreting α-melanocyte stimulating hormone. Inhibition of these neurons would increase appetite rather than decrease it.B: Decreased hypothalamic neuropeptide Y 