<prompt> Please answer with one of the option in the bracket. Write reasoning in between . Write answer in between .Q:An 8-year-old African-American boy is brought to the emergency room with severe pain in both hands. His mother says that the patient had a fever with a cough a couple of days ago. Family history is positive for an uncle who died from a blood disease. A peripheral blood smear of this patient is shown in the image. Which of the following is the most likely mechanism for this patients disease?? A: Nonsense mutation, B: Frameshift mutation, C: Mismatch repair, D: Silent mutation, E: Missense mutation,  <response>: Based on the information provided in the question stem, this is likely a case of sickle cell disease in an 8-year-old African American boy presenting with severe pain in his hands likely vaso-occlusive crisis and positive family history of a blood disorder. The peripheral blood smear shows sickled RBCs, which is characteristic of sickle cell disease. Sickle cell disease is caused by a point mutation in the beta globin gene, leading to abnormal hemoglobin production. This is an example of a missense mutation, where a single nucleotide substitution leads to an amino acid substitution that changes the structure and function of the hemoglobin protein.E: Missense mutation 