<prompt> Please answer with one of the option in the bracket. Write reasoning in between . Write answer in between .Q:A 40-year-old male presents to his primary care physician complaining of upper abdominal pain. He reports a four-month history of crampy epigastric pain that improves with meals. His past medical history is significant for hypertension that has been well controlled by lisinopril. He does not smoke and drinks alcohol occasionally. His family history is notable for a maternal uncle with acromegaly and a maternal grandfather with parathyroid adenoma requiring surgical resection. Based on clinical suspicion laboratory serum analysis is obtained and shows abnormal elevation of a peptide. This patient most likely has a mutation in which of the following chromosomes?? A: 5, B: 10, C: 11, D: 13, E: 17,  <response>: Based on the patients symptoms of upper abdominal pain that improves with meals, family history of endocrine tumors, and lab findings of elevated peptide levels, this patient likely has a gastrinoma tumor causing Zollinger-Ellison syndrome. Gastrinomas are neuroendocrine tumors that secrete excess gastrin, leading to increased gastric acid production and peptic ulcer disease. The underlying cause in most sporadic cases of gastrinoma is a mutation in the MEN1 gene located on chromosome 11. MEN1 mutations lead to multiple endocrine neoplasia type 1, which is associated with hyperparathyroidism and pituitary tumors, consistent with this patients family history. Therefore, the most likely chromosome mutation is chromosome 11.C: 11 