<prompt> Please answer with one of the option in the bracket. Write reasoning in between . Write answer in between .Q:A 59-year-old man presents to a clinic with exertional chest pain for the past several months. He says the pain is central in his chest and relieved with rest. The physical examination is unremarkable. An electrocardiogram is normal, but an exercise tolerance test revealed ST-segment depression in chest leads V1-V4. He is prescribed nitroglycerin to be taken in the first half of the day. Which of the following statements best describes the reason behind the timing of this medication?? A: To prevent collapse, B: To avoid nitrate headache, C: More effective in patients with angina due to anemia, D: To prevent methemoglobinemia, E: To avoid nitrate tolerance,  <response>: This is a clinical vignette describing a patient with typical angina symptoms and objective evidence of ischemia on exercise testing. The question asks about the reason for prescribing nitroglycerin in the first half of the day in this patient.Choice A is incorrect because nitroglycerin does not prevent collapse in patients with stable angina. Choice B is a possible reason, as nitrates can cause headaches with frequent or high dosing. However, this does not explain why it should be taken in the first half of the day specifically.Choice C is incorrect because there is no evidence this patient has anemia. Nitrates are not more effective in anemic patients with angina.Choice D is incorrect because methemoglobinemia is not a major concern with appropriate nitrate dosing. Choice E is the correct answer. Nitrate tolerance can develop with frequent or continuous dosing. Recommending nitrate use in the first half of the day provides a nitrate-free period to help prevent tolerance.E: To avoid nitrate tolerance 