<prompt> Please answer with one of the option in the bracket. Write reasoning in between . Write answer in between .Q:A 39-year-old woman with multiple sclerosis comes to the physician for a follow-up examination. Over the past 3 years, she has been hospitalized 7 times for acute exacerbations of her illness. She has not responded to therapy with several disease-modifying agents and has required at least two pulse corticosteroid therapies every year. She has seen several specialists and sought out experimental therapies. During this time period, her disease course has been rapidly progressive. She currently requires a wheelchair and is incontinent. Today, she says, Im not going to allow myself to hope because Ill only be disappointed, like I have been over and over again. Whats the point? No one in this system knows how to help me. Sometimes I dont even take my pills any more because they dont help. Which of the following is the most appropriate initial response to this patient?? A: I am moved by your courage in the face of this senseless tragedy. I agree with you that further therapy is futile, and I am going to recommend that we stop further treatments., B: While I completely understand your hopelessness about the lack of improvement, not taking your medication as instructed is only going to make things worse., C: Im very sorry to hear that you feel this way about your situation. With all that youve been through, I can see why you would be so frustrated., D: I understand how your illness would make you angry. Apparently your previous doctors did not know how to help you handle your condition well, but I believe I can help you., E: I am concerned that this terrible illness may be affecting your capacity to make decisions for yourself and would like to refer you to a psychiatrist.,  <response>: This is a question about how to respond appropriately to a patient expressing hopelessness and frustration with her chronic illness. The key points in the stem are that the patient has a progressive neurological disease that has not responded to multiple treatments, she feels hopeless and has stopped taking her medications, and she expresses frustration with the medical systems inability to help her. The answer should validate the patients feelings while avoiding agreement with inaccurate beliefs, reinforcing nonadherence, blaming previous providers, or questioning the patients decision-making capacity without cause.Choice A agrees with the patients sense of futility and suggests stopping treatment, which is inappropriate. Choice B focuses only on the medication nonadherence, ignoring the broader issues. Choice C validates the patients feelings of frustration and hopelessness. This would be an empathetic response.Choice D inappropriately suggests previous doctors are to blame for not helping the patient handle her illness. Choice E raises concern about the patients decision-making capacity without justification.Therefore, choice C provides the most appropriate initial response by acknowledging the patients feelings without reinforcing inaccurate beliefs or inappropriate actions.C: Im very sorry to hear that you feel this way about your situation. With all that youve been through, I can see why you would be so frustrated. 