<prompt> Please answer with one of the option in the bracket. Write reasoning in between . Write answer in between .Q:Which of the following patient presentations would be expected in an infant with defective LFA-1 integrin CD18 protein on phagocytes, in addition to recurrent bacterial infections?? A: Eczema and thrombocytopenia, B: Skin infections with absent pus formation, delayed umbilicus separation, C: Cardiac defects, hypoparathyroidism, palatal defects, and learning disabilities, D: Chronic diarrhea, oral candidiasis, severe infections since birth, absent thymic shadow, E: Progressive neurological impairment and cutaneous telangiectasia,  <response>: This is asking about the expected clinical manifestations in an infant with defective LFA-1 integrin, in addition to recurrent bacterial infections. LFA-1 integrin is found on leukocytes and is important for leukocyte adhesion and migration. Defects in LFA-1 can lead to leukocyte adhesion deficiency type 1 LAD-1, which causes recurrent bacterial infections due to impaired leukocyte function.Choice A describes features of Wiskott-Aldrich syndrome, not expected with LFA-1 defects. Choice C describes DiGeorge syndrome, also not related to LFA-1 defects. Choice D describes severe combined immunodeficiency, which can present similarly but is distinct from LAD-1. Choice E describes ataxia telangiectasia, unrelated to LFA-1 defects. Choice B describes some of the key features of LAD-1 - impaired pus formation and delayed umbilical cord separation due to impaired leukocyte recruitment and function. This is the expected presentation in addition to recurrent infections.B: Skin infections with absent pus formation, delayed umbilicus separation 