<prompt> Please answer with one of the option in the bracket. Write reasoning in between . Write answer in between .Q:A 2-year-old boy presents to the doctor with multiple skin abscesses caused by Staphylococcus aureus. He has a past history of recurrent infections with the same organism. The nitroblue tetrazolium test is performed, and the solution remains clear. Which of the following key pathophysiologic events relates to the condition that is most likely responsible for the findings in this patient?? A: Deficiency of CD40L on activated T cells, B: Tyrosine kinase deficiency blocking B cell maturation, C: Inability to fuse lysosomes with phagosomes, D: MHC class-II deficiency, E: Inability to generate the microbicidal respiratory burst,  <response>: This is a clinical vignette describing a 2-year-old boy with recurrent skin abscesses caused by Staphylococcus aureus. The nitroblue tetrazolium NBT test was performed and remained clear. The NBT test evaluates the ability of phagocytes to generate superoxide as part of the respiratory burst involved in killing ingested microorganisms. A clear result indicates an inability to generate superoxide and a defective respiratory burst.The choices describe various immunodeficiencies. Choice A relates to T cell help for B cell activation. Choice B relates to a B cell maturation defect. Choice C relates to a defect in phagolysosome formation. Choice D relates to MHC class II deficiency affecting antigen presentation. Choice E describes an inability to generate the respiratory burst, which directly relates to the clear NBT test result in this patient. This suggests a defect in NADPH oxidase, which is required for the respiratory burst.E: Inability to generate the microbicidal respiratory burst 