<prompt> Please answer with one of the option in the bracket. Write reasoning in between . Write answer in between .Q:A 40-year-old woman in her 18th week of pregnancy based on the last menstrual period LMP presents to her obstetrician for an antenatal check-up.The antenatal testing is normal, except the quadruple screen results which are given below:Maternal serum alpha-fetoprotein MS-AFP lowUnconjugated estriol lowHuman chorionic gonadotropin hCG highInhibin-A highWhich of the following conditions is the most likely the cause of the abnormal quadruple screen?? A: Trisomy 21, B: Spina bifida, C: Omphalocele, D: Gastroschisis, E: Fetal alcohol syndrome,  <response>: This is a question about interpreting quadruple screen results in pregnancy. The key findings in the quadruple screen results are:- Low MS-AFP - Low unconjugated estriol- High hCG- High inhibin-ALow MS-AFP and unconjugated estriol along with high hCG and inhibin-A indicate an increased risk for Down syndrome trisomy 21. Spina bifida, omphalocele, gastroschisis and fetal alcohol syndrome would not cause this particular pattern of quadruple screen results.A: Trisomy 21 