<prompt> Please answer with one of the option in the bracket. Write reasoning in between . Write answer in between .Q:A 65-year-old man comes to the physician for a routine health maintenance examination. He has a strong family history of colon cancer. A screening colonoscopy shows a 4 mm polyp in the upper sigmoid colon. Which of the following findings on biopsy is associated with the lowest potential for malignant transformation into colorectal carcinoma?? A: Branching tubules embedded in lamina propria, B: Tree-like branching of muscularis mucosa, C: Regenerating epithelium with inflammatory infiltrate, D: Finger-like projections with a fibrovascular core, E: Hyperplastic epithelium at the base of crypts,  <response>: This is a question about identifying the biopsy finding associated with the lowest risk of malignant transformation in a colon polyp. It provides a clinical scenario of a 65 year old man with a family history of colon cancer who is found to have a 4mm polyp in the sigmoid colon on screening colonoscopy. To answer this, we need to know which histological features of colon polyps are associated with higher or lower risk of developing into colorectal cancer. Small polyp size 4mm suggests lower risk. Location in the upper sigmoid colon is less concerning than proximal colon. The key is recognizing that hyperplastic polyps have the lowest risk of malignant transformation, while tubulovillous and villous adenomas with increasing villous components have higher risks of malignancy. Serrated polyps like traditional serrated adenomas have intermediate risk. Regenerative changes and inflammation are not specific histological findings.E: Hyperplastic epithelium at the base of crypts 