<prompt> Please answer with one of the option in the bracket. Write reasoning in between . Write answer in between .Q:A clinical trial is being run with patients that have a genetic condition characterized by abnormal hemoglobin that can undergo polymerization when exposed to hypoxia, acidosis, or dehydration. This process of polymerization is responsible for the distortion of the red blood cell RBC that acquires a crescent shape and the hemolysis of RBCs. Researchers are studying the mechanisms of the complications commonly observed in these patients such as stroke, aplastic crisis, and auto-splenectomy. What kind of mutation leads to the development of the disease?? A: Missense mutation, B: Nonsense mutation, C: Splice site, D: Frameshift mutation, E: Silent mutation,  <response>: This is a question about a genetic condition that leads to abnormal hemoglobin that can polymerize under certain conditions, causing distorted RBCs and hemolysis. This process leads to complications like stroke, aplastic crisis, and auto-splenectomy. The question asks what kind of mutation leads to this disease. Based on the description, it seems to be referring to sickle cell disease. This is caused by a missense mutation in the beta globin gene that leads to the production of abnormal hemoglobin S that can polymerize.So the correct answer should be a mutation that leads to a amino acid substitution in the encoded protein. A missense mutation is a point mutation that results in a different amino acid. The other mutations listed would not lead to an amino acid substitution.A: Missense mutation 