<prompt> Please answer with one of the option in the bracket. Write reasoning in between . Write answer in between .Q:A 25-year-old man with a genetic disorder presents for genetic counseling because he is concerned about the risk that any children he has will have the same disease as himself. Specifically, since childhood he has had difficulty breathing requiring bronchodilators, inhaled corticosteroids, and chest physiotherapy. He has also had diarrhea and malabsorption requiring enzyme replacement therapy. If his wife comes from a population where 1 in 10,000 people are affected by this same disorder, which of the following best represents the likelihood a child would be affected as well?? A: 0.01, B: 0.5, C: 1, D: 2, E: 50,  <response>: This is a question about calculating genetic risk. The man has an autosomal recessive genetic disorder, meaning he has two copies of the abnormal gene. His wife is from the general population where the disorder is very rare 1 in 10,000. For a child to be affected, they would need to inherit one abnormal gene copy from the father and one from the mother. The mothers chance of being a carrier is approximately 1 in 100 since carriers are much more common than affected individuals for a recessive disorder. Therefore, the chance the child inherits an abnormal gene from the mother is 1 and from the father is 100. The chance of both events happening is the product of the individual risks, which is 1.C: 1 