<prompt> Please answer with one of the option in the bracket. Write reasoning in between . Write answer in between .Q:A 2-year-old boy has a history of recurrent bacterial infections, especially of his skin. When he has an infection, pus does not form. His mother reports that, when he was born, his umbilical cord took 5 weeks to detach. He is ultimately diagnosed with a defect in a molecule in the pathway that results in neutrophil extravasation. Which of the following correctly pairs the defective molecule with the step of extravasation that molecule affects?? A: ICAM-1; margination, B: LFA-1 integrin; margination, C: LFA-1 integrin; tight adhesion, D: E-selectin; tight adhesion, E: E-selectin; transmigration,  <response>: This is a question about the molecular mechanisms involved in neutrophil extravasation. The key details in the question stem are that the patient has recurrent bacterial infections, lacks pus formation, and has delayed umbilical cord detachment, indicating impaired neutrophil extravasation. The question asks to identify the defective molecule and the step of extravasation it affects. Going through the choices:A ICAM-1 is involved in tight adhesion, not margination, so this is incorrect. B LFA-1 is involved in tight adhesion, not margination, so this is incorrect.C LFA-1 is correct for tight adhesion. This is likely the right answer.D E-selectin is involved in rollingmargination, not tight adhesion, so this is incorrect.E E-selectin is involved in rollingmargination, not transmigration, so this is incorrect.C: LFA-1 integrin; tight adhesion 