<prompt> Please answer with one of the option in the bracket. Write reasoning in between . Write answer in between .Q:A 28-year-old G2P1 female is concerned that she may give birth to another child with Down syndrome. She states that she may not be able to take care of another child with this disorder. Which of the following tests can confirm the diagnosis of Down syndrome in utero?? A: Triple marker test, B: Quadruple marker test, C: Integrated test, D: Ultrasound, E: Amniocentesis,  <response>: This is a question asking about prenatal testing that can confirm a diagnosis of Down syndrome in the fetus. The triple marker, quadruple marker, and integrated tests are screening tests that assess the risk of Down syndrome but cannot definitively diagnose it. Ultrasound may raise suspicion for Down syndrome based on findings but does not confirm the diagnosis. Amniocentesis allows for karyotype analysis of fetal cells obtained via amniocentesis, which can confirm the presence or absence of an extra chromosome 21, thus confirming or ruling out Down syndrome.E: Amniocentesis 