<prompt> Please answer with one of the option in the bracket. Write reasoning in between . Write answer in between .Q:A 67-year-old woman comes to the physician with a 6-month history of pain and swelling of both legs. The symptoms are worst at the end of the day and are associated with itching of the overlying skin. Physical examination shows bilateral pitting ankle edema. An image of one of the ankles is shown. This patient is at greatest risk for which of the following complications?? A: Thrombosis of a deep vein, B: Malignant transformation of lymphatic endothelium, C: Biliverdin accumulation in the epidermis, D: Osmotic injury to the peripheral nerves, E: Ulceration of the cutis,  <response>: This is a clinical vignette describing a 67-year-old woman with a 6-month history of bilateral leg swelling and itching that worsens throughout the day. The description and image are consistent with chronic venous insufficiencystasis dermatitis. The swelling and skin changes are due to impaired venous return from the lower extremities. Of the answer choices, ulceration of the skin choice E is the most likely complication of chronic venous stasis and increased venous pressure. Thrombosis choice A can occur but is less common than skin ulceration. The other choices are unrelated to chronic venous insufficiency.E: Ulceration of the cutis 