<prompt> Please answer with one of the option in the bracket. Write reasoning in between . Write answer in between .Q:A neonate is noted to have very light skin, light blue eyes, and sparse blonde-white hair. The family states that the baby is much lighter in appearance than anyone else in the family. Both parents are Fitzpatrick skin type III with dark brown hair. On further exam, the babys temperature is 98.4F 36.9C, blood pressure is 11070 mmHg, pulse is 88min, and respirations are 14min. The patient is oxygenating well at SpO2 of 97 on room air with no respiratory distress. All reflexes are appropriate, and the APGAR score is 10. A referral is placed with Ophthalmology for a comprehensive eye exam. The condition is believed to be due to an enzyme deficiency, and a hair bulb assay is performed. Which of the following substrates should be incubated with the specimen in order to determine the activity of the enzyme in question for this disease?? A: Dihydroxyphenylalanine, B: Dopamine, C: Homogentisic Acid, D: Pyridoxine, E: Tetrahydrobiopterin,  <response>: This is a clinical vignette describing a newborn with very light skin, light blue eyes, and sparse blonde-white hair. The description of the patients appearance and ethnicity suggests albinism as a likely diagnosis. The question asks which substrate should be incubated with a hair bulb assay specimen to determine the enzyme deficiency causing this disease. Albinism is caused by a deficiency in tyrosinase, an enzyme required for melanin production. Tyrosinase converts tyrosine to dihydroxyphenylalanine DOPA as one of the first steps in melanin synthesis. Therefore, the correct substrate to test tyrosinase activity in a hair bulb assay for this patient would be tyrosine or dihydroxyphenylalanine DOPA.A: Dihydroxyphenylalanine 