<prompt> Please answer with one of the option in the bracket. Write reasoning in between . Write answer in between .Q:A 64-year-old female with type 2 diabetes mellitus comes to the physician because of a 1-week history of painful red swelling on her left thigh. Examination shows a 3- x 4-cm, tender, fluctuant mass. Incision and drainage of the abscess are performed. Culture of the abscess fluid grows gram-positive, coagulase-positive cocci that are resistant to oxacillin. Which of the following best describes the mechanism of resistance of the causal organism to oxacillin?? A: Degradation of the antibiotic, B: Decreased uptake of the antibiotic, C: Acetylation of the antibiotic, D: Altered target of the antibiotic, E: Decreased activation of the antibiotic,  <response>: This is a medical question asking about the mechanism of resistance of Staphylococcus aureus to the antibiotic oxacillin. The patient has a thigh abscess caused by S. aureus that is resistant to oxacillin. Oxacillin is a beta-lactam antibiotic that inhibits cell wall synthesis. Resistance of S. aureus to beta-lactams like oxacillin is usually mediated by production of an altered penicillin-binding protein PBP2a that has low affinity for beta-lactams. This prevents the antibiotic from binding to its target and inhibiting cell wall synthesis. So the mechanism of resistance is alteration of the antibiotics target.D: Altered target of the antibiotic 