<prompt> Please answer with one of the option in the bracket. Write reasoning in between . Write answer in between .Q:A 55-year-old man comes to the physician because of a 4-month history of episodic, pressure-like chest pain. The chest pain occurs when he is walking up stairs and improves with rest. He has hypertension and type 2 diabetes mellitus. His father died from a myocardial infarction at the age of 50 years. Current medications include hydrochlorothiazide and metformin. His pulse is 85min, respirations are 12min, and blood pressure is 14090 mm Hg. Cardiac examination shows normal heart sounds without any murmurs, rubs, or gallops. An ECG shows high amplitude of the S wave in lead V3. An exercise stress test is performed but stopped after 4 minutes because the patient experiences chest pain. An ECG obtained during the stress test shows sinus tachycardia and ST-segment depressions in leads V1V4. Which of the following is the most appropriate long-term pharmacotherapy to reduce the frequency of symptoms in this patient?? A: Isosorbide mononitrate, B: Nitroglycerin, C: Aspirin, D: Metoprolol, E: Clopidogrel,  <response>: This is a question about choosing appropriate long-term pharmacotherapy for a 55-year-old man with chest pain suggestive of angina. The key findings in the stem are a 4-month history of exertional chest pain, cardiac risk factors of hypertension, diabetes and family history of early myocardial infarction, and ECG changes during an exercise stress test showing ischemia. The choices include nitrates isosorbide mononitrate, nitroglycerin which can relieve angina symptoms but are not first-line long-term medications. Aspirin and clopidogrel are antiplatelet agents which do not directly treat angina. Metoprolol is a beta-blocker which is an appropriate first-line medication for chronic stable angina. It works by decreasing myocardial oxygen demand.D: Metoprolol 