<prompt> Please answer with one of the option in the bracket. Write reasoning in between . Write answer in between .Q:A 48-year-old male presents to his primary physician with the chief complaints of fever, abdominal pain, weight loss, muscle weakness, and numbness in his lower extremities. UA is normal. A biopsy of the sural nerve reveals transmural inflammation and fibrinoid necrosis of small and medium arteries. Chart review reveals a remote history of cigarette smoking as a teenager and Hepatitis B seropositivity. What is the most likely diagnosis?? A: Polyarteritis nodosa, B: Microscopic polyangiitis, C: Thromboangiitis obliterans, D: Raynaud disease, E: Systemic lupus erythematosis,  <response>: This is a clinical vignette describing a 48-year-old male with fever, abdominal pain, weight loss, muscle weakness, and numbness in the lower extremities. The key findings are transmural inflammation and fibrinoid necrosis of small and medium arteries on sural nerve biopsy. The patient also has a history of smoking and Hepatitis B. Based on the biopsy findings of necrotizing vasculitis affecting small and medium sized vessels, the most likely diagnosis is polyarteritis nodosa PAN. PAN often affects middle aged males and is associated with hepatitis B. The systemic symptoms described are typical of PAN. The other answer choices can be ruled out:Microscopic polyangiitis - affects small vessels, not medium sized.Thromboangiitis obliterans - affects large vessels. Raynaud disease - no evidence of ischemic changes.Systemic lupus erythematosus - no serologic or clinical evidence.A: Polyarteritis nodosa 