<prompt> Please answer with one of the option in the bracket. Write reasoning in between . Write answer in between .Q:A group of researchers recently conducted a meta-analysis of twenty clinical trials encompassing 10,000 women with estrogen receptor-positive breast cancer who were disease-free following adjuvant radiotherapy. After an observation period of 15 years, the relationship between tumor grade and distant recurrence of cancer was evaluated. The results show:Distant recurrence No distant recurrenceWell differentiated 500 4500Moderately differentiated 375 2125Poorly differentiated 550 1950Based on this information, which of the following is the 15-year risk for distant recurrence in patients with high-grade breast cancer?? A: 5501425, B: 5005000, C: 5502500, D: 250010000, E: 19508575,  <response>: This is a question about interpreting data from a meta-analysis study evaluating the relationship between tumor grade and risk of distant recurrence in breast cancer patients. The data table provides the number of patients with and without distant recurrence broken down by tumor grade well, moderately, and poorly differentiated. To determine the 15-year risk of distant recurrence in patients with high grade tumors, we need to look at the data for poorly differentiated tumors. 550 patients had distant recurrence out of a total of 2500 poorly differentiated patients. So the 15-year risk of distant recurrence in this high grade group is 5502500.C: 5502500 