<prompt> Please answer with one of the option in the bracket. Write reasoning in between . Write answer in between .Q:A 34-year-old man comes to the physician for a 2-month history of an itchy rash on his forearm. He feels well otherwise and has not had any fever or chills. He returned from an archaeological expedition to Guatemala 4 months ago. Skin examination shows a solitary, round, pink-colored plaque with central ulceration on the right wrist. There is right axillary lymphadenopathy. A photomicrograph of a biopsy specimen from the lesion is shown. Which of the following is the most likely causal organism?? A: Treponema pallidum, B: Trypanosoma brucei, C: Ancylostoma duodenale, D: Borrelia burgdorferi, E: Leishmania braziliensis,  <response>: This is a clinical vignette describing a patient with a skin lesion after returning from travel to Guatemala. The key findings are a solitary round pink plaque with central ulceration and lymphadenopathy. The biopsy photomicrograph shows histiocytes containing intracellular amastigotes, which are characteristic of cutaneous leishmaniasis. The choices include various infectious organisms. Treponema pallidum causes syphilis. Trypanosoma brucei causes African sleeping sickness. Ancylostoma duodenale causes hookworm. Borrelia burgdorferi causes Lyme disease. Leishmania braziliensis causes cutaneous leishmaniasis. Based on the travel history to Guatemala and the biopsy findings, Leishmania braziliensis is the most likely organism causing this patients skin lesion.E: Leishmania braziliensis 