<prompt> Please answer with one of the option in the bracket. Write reasoning in between . Write answer in between .Q:A 50-year-old man comes to the physician for the evaluation of recurrent episodes of chest pain, difficulty breathing, and rapid heart beating over the past two months. During this period, he has had a 4-kg 8.8-lb weight loss, malaise, pain in both knees, and diffuse muscle pain. Five years ago, he was diagnosed with chronic hepatitis B infection and was started on tenofovir. His temperature is 38C 100.4F, pulse is 110min, and blood pressure is 15090 mm Hg. Cardiopulmonary examination shows no abnormalities except for tachycardia. There are several ulcerations around the ankle and calves bilaterally. Laboratory studies show:Hemoglobin 11 gdLLeukocyte count 14,000mm3Erythrocyte sedimentation rate 80 mmhSerumPerinuclear anti-neutrophil cytoplasmic antibodies negativeHepatitis B surface antigen positiveUrineProtein 2RBC 6-7hpfWhich of the following is the most likely diagnosis?? A: Takayasu arteritis, B: Giant cell arteritis, C: Polyarteritis nodosa, D: Thromboangiitis obliterans, E: Granulomatosis with polyangiitis,  <response>: This is a clinical vignette describing a 50-year-old man with recurrent chest pain, shortness of breath, rapid heart rate, weight loss, malaise, joint pain, fever, hypertension, and leg ulcers. He has a history of chronic hepatitis B infection and is on tenofovir. Lab tests show anemia, leukocytosis, elevated ESR, and urine abnormalities. The key findings pointing to the diagnosis are:- Systemic symptoms like weight loss, malaise, fever- Vasculopathic features like hypertension, leg ulcers - Positive hepatitis B serology- Negative ANCA serologyThis presentation is most consistent with polyarteritis nodosa PAN, a necrotizing vasculitis of medium and small arteries that can be associated with hepatitis B infection. The systemic symptoms, vasculopathy, and negative ANCA make giant cell arteritis, Takayasu arteritis, and granulomatosis with polyangiitis less likely. Thromboangiitis obliterans does not explain the systemic symptoms.C: Polyarteritis nodosa 