<prompt> Please answer with one of the option in the bracket. Write reasoning in between . Write answer in between .Q:A 36-year-old software professional consults a physician to discuss his concerns about small-vessel vasculitis as his mother and sister both have autoimmune small-vessel vasculitides. He has read about vasculitides and recently he came across an article which stated that an analgesic that he often uses for relief from a headache can cause small-vessel vasculitis. Due to his positive family history, he is especially concerned about his risk of developing small-vessel vasculitis. Which of the following clinical presentations is most likely to occur in this man?? A: Absence of pulses in the upper extremity, B: Infarction of an internal organ, C: Stroke, D: Aneurysm of an artery, E: Palpable purpura,  <response>: This is a clinical vignette about a 36-year-old man with a family history of small vessel vasculitis who is concerned he may develop it himself due to his frequent use of an analgesic that can cause it. The question asks which clinical presentation is most likely to occur in this scenario.Based on the information provided, the man does not currently have signs or symptoms of vasculitis. However, he is worried about developing it in the future due to his family history and analgesic use. Small vessel vasculitides like ANCA-associated vasculitis and immune complex-mediated vasculitides can present with palpable purpura, which is a rash caused by inflammation and hemorrhage in small blood vessels in the skin. This would be the most likely early clinical manifestation in someone at risk for but not yet diagnosed with small vessel vasculitis.The other answer choices describe vascular complications that would occur later in the disease course such as organ infarction, aneurysm, or stroke. Absence of pulses in the upper extremity could be seen but would not be the most common initial presentation.E: Palpable purpura 