<prompt> Please answer with one of the option in the bracket. Write reasoning in between . Write answer in between .Q:A 24-year-old man presents to the physician because of headache, malaise, fatigue, aching pain in the bones, and a non-itchy skin rash for the past week. He reports that he had developed a single, raised, red-colored eruption over the glans penis 2 months ago, which had healed spontaneously 1 month ago. Physical examination shows bilaterally symmetric, discrete, round, pale-red-colored, 510 mm-sized macules on his trunk and extremities, including over the palms and soles. His genital examination shows reddish-brown plaques on the penis. Venereal disease research laboratory test is positive and high-sensitivity enzyme-linked immunosorbent assay for HIV is negative. Fluorescent treponemal antibody-absorption test is positive. Eight hours after the administration of intramuscular benzathine penicillin, the patient presents to the emergency department with complaints of fever with chills, worsening headache, muscle pains, and worsening of his pre-existing skin lesions for the past 4 hours. There is no history of itching. His temperature is 38.5C 101.3F, heart rate is 108min, respiratory rate is 24min, and blood pressure is 10476 mm Hg. There is no bronchospasm. His complete blood count shows leukocytosis with lymphopenia. What is the most appropriate next step in management?? A: Prescribe an antipyretic and an analgesic for symptom relief, B: Prescribe oral prednisone for 5 days, C: Administer intravenous diphenhydramine, D: Administer intramuscular epinephrine, E: Prescribe doxycycline for 28 days,  <response>: This is a question about the management of a patient with worsening symptoms after receiving intramuscular benzathine penicillin for syphilis. The key findings in the stem are:- 24-year-old man with headache, malaise, fatigue, bone pain, and rash for 1 week- History of painless genital lesion 2 months ago that resolved spontaneously - Physical exam shows macules on trunkextremities and plaques on penis- Positive VDRL and negative HIV test indicate early syphilis- Positive FTA-ABS confirms diagnosis of syphilis- Worsening symptoms 4 hours after benzathine penicillin injection- Fever, chills, headache, muscle pains, worsening rash - No itching or bronchospasm- Leukocytosis with lymphopeniaThis clinical presentation is most consistent with a Jarisch-Herxheimer reaction, which is an acute worsening of symptoms after antibiotic treatment for syphilis. It is a self-limited reaction caused by the release of treponemal endotoxins.The correct management is to provide symptomatic relief with antipyretics and analgesics. Steroids may provide some benefit but are not first-line. Antihistamines and epinephrine are not indicated since there is no evidence of an allergic reaction or anaphylaxis. Doxycycline may be used for treatment but will not address the acute reaction.A: Prescribe an antipyretic and an analgesic for symptom relief 