<prompt> Please answer with one of the option in the bracket. Write reasoning in between . Write answer in between .Q:A 13-month-old girl is brought to the pediatric clinic by her mother due to progressive abdominal distension, poor feeding, and failure to thrive. The perinatal history was uneventful. The family emigrated from Sudan 8 years ago. The vital signs include: temperature 36.8C 98.2F, blood pressure 10055 mm Hg, and pulse 99min. The physical examination shows conjunctival pallor, hepatosplenomegaly, and parietal and frontal bossing of the skull. The laboratory test results are as follows:Hemoglobin 8.7 gdLMean corpuscular volume 62 μm3Red cell distribution width 12.2 normal value is 11.514.5Reticulocyte count 2.1 Leucocyte count 10,200mm3Platelet count 392,000mm3The peripheral blood smear shows microcytic red cells, target cells, and many nucleated red cells. Which of the following is the most likely diagnosis?? A: Alpha-thalassemia major, B: Glucose-6-phosphate dehydrogenase deficiency, C: Sickle cell disease, D: Congenital dyserythropoietic anaemia, E: Beta-thalassemia major,  <response>: Based on the information provided in the question stem, the key findings are:- 13-month-old girl with abdominal distension, poor feeding, failure to thrive- Uneventful perinatal history - Originally from Sudan- Physical exam shows pallor, hepatosplenomegaly, skull bossing- Lab results show microcytic anemia, target cells, nucleated RBCsThe microcytic anemia along with target cells and nucleated RBCs point towards a hemoglobinopathy. The girls ancestry from Sudan makes beta-thalassemia major likely. The age of presentation and physical exam findings also fit with this diagnosis.E: Beta-thalassemia major 