<prompt> Please answer with one of the option in the bracket. Write reasoning in between . Write answer in between .Q:A 44-year-old man comes to the physician because of fatigue and increased straining during defecation for 3 months. During this time, he has lost 5 kg 12 lb despite no change in appetite. He has a family history of colon cancer in his maternal uncle and maternal grandfather. His mother died of ovarian cancer at the age of 46. Physical examination shows conjunctival pallor. His hemoglobin concentration is 11.2 gdL, hematocrit is 34, and mean corpuscular volume is 76 μm3. Colonoscopy shows an exophytic mass in the ascending colon. Pathologic examination of the resected mass shows a poorly differentiated adenocarcinoma. Genetic analysis shows a mutation in the MSH2 gene. Which of the following is the most likely diagnosis?? A: Familial adenomatous polyposis, B: Turcot syndrome, C: Peutz-Jeghers syndrome, D: Gardner syndrome, E: Lynch syndrome,  <response>: This is a clinical vignette describing a 44-year-old man with fatigue, increased straining during defecation, weight loss, family history of colon cancer, conjunctival pallor, anemia, and a colon mass found to be poorly differentiated adenocarcinoma. He has a mutation in the MSH2 gene. The key findings pointing to the diagnosis are:- Family history of colon cancer and ovarian cancer at young age - Patient developed colon cancer at age 44- MSH2 gene mutation- Poorly differentiated adenocarcinoma on pathologyThese findings are most consistent with Lynch syndrome, an autosomal dominant condition that leads to increased risk of early-onset colorectal and other cancers due to DNA mismatch repair gene mutations like MSH2.The other choices do not fit with the clinical vignette:- Familial adenomatous polyposis causes hundreds to thousands of colon polyps, not described here- Turcot syndrome involves brain tumors, not described here - Peutz-Jeghers syndrome causes hamartomatous GI polyps and mucocutaneous pigmentation, not described here- Gardner syndrome is a variant of FAP, not described hereE: Lynch syndrome 