<prompt> Please answer with one of the option in the bracket. Write reasoning in between . Write answer in between .Q:A 32-year-old woman comes to the physician because of a 4-day history of low-grade fever, joint pain, and muscle aches. The day before the onset of her symptoms, she was severely sunburned on her face and arms during a hike with friends. She also reports being unusually fatigued over the past 3 months. Her only medication is a combined oral contraceptive pill. Her temperature is 37.9C 100.2F. Examination shows bilateral swelling and tenderness of the wrists and metacarpophalangeal joints. There are multiple nontender superficial ulcers on the oral mucosa. The detection of antibodies directed against which of the following is most specific for this patients condition?? A: Cell nucleus, B: Single-stranded DNA, C: Fc region of IgG, D: Nuclear Sm proteins, E: Histonesn,  <response>: This is a medical question asking about the most specific antibody for diagnosing the patients condition based on the clinical vignette. The patient has a recent history of sunburn, low-grade fever, joint pain, muscle aches, fatigue, oral ulcers, and wristhand swelling and tenderness. This presentation is most consistent with systemic lupus erythematosus SLE. The most specific antibody for SLE is anti-nuclear antibodies, particularly those directed against double-stranded DNA and nuclear Sm proteins. Anti-histone antibodies can also be seen in SLE, but are less specific. The other options listed are not specific for SLE.D: Nuclear Sm proteins 