<prompt> Please answer with one of the option in the bracket. Write reasoning in between . Write answer in between .Q:A 57-year-old man comes to the physician with a 9-month history of cough and progressive dyspnea. The cough is usually worse in the mornings. He has smoked two packs of cigarettes daily for 30 years. Pulmonary examination shows diffuse wheezing during expiration. Spirometry shows a FEV1:FVC ratio of 45. An x-ray of the chest shows widened intercostal spaces and generalized hyperlucency of the pulmonary parenchyma. Increased activity of which of the following types of cells is most likely responsible for this patients pulmonary condition?? A: Th2 cells, B: Type I alveolar cells, C: Type II alveolar cells, D: Mast cells, E: Neutrophil cells,  <response>: This is a patient with a long history of heavy smoking who now has symptoms and findings consistent with chronic obstructive pulmonary disease COPD. The key findings are chronic cough, dyspnea, heavy smoking history, wheezing on exam, reduced FEV1:FVC ratio on spirometry, and hyperinflation on chest x-ray. In COPD, the underlying pathology is destruction of lung parenchyma and enlargement of airspaces due to an inflammatory response to inhaled particles and gases, especially from cigarette smoke. This inflammatory response involves several cell types, but is predominantly driven by increased activity of neutrophils and macrophages. Neutrophils release proteolytic enzymes that damage lung tissue, while macrophages release inflammatory mediators that perpetuate the inflammatory response. This chronic inflammation leads to the airway obstruction, emphysema enlargement of airspaces, and hyperinflation that characterize COPD.So out of the answer choices, increased activity of neutrophil cells is most responsible for the lung findings described in this patient with COPD.E: Neutrophil cells 