<prompt> Please answer with one of the option in the bracket. Write reasoning in between . Write answer in between .Q:A newborn male, delivered by emergency Cesarean section during the 28th week of gestation, has a birth weight of 1.2 kg 2.5 lb. He develops rapid breathing 4 hours after birth. Examination of the respiratory system reveals a respiratory rate of 80min, expiratory grunting, intercostal and subcostal retractions with nasal flaring. His chest radiograph shows bilateral diffuse reticulogranular opacities and poor lung expansion. His echocardiography suggests a diagnosis of patent ductus arteriosus with left-to-right shunt and signs of fluid overload. The pediatrician administers intravenous indomethacin to facilitate closure of the duct. Which of the following effects best explains the mechanism of action of this drug in the management of this neonate?? A: Inhibition of lipoxygenase, B: Increased synthesis of prostaglandin E2, C: Decreased blood flow in the vasa vasorum of the ductus arteriosus, D: Induction of endothelial nitric oxide synthase, E: Increased synthesis of platelet-derived growth factor PDGF,  <response>: This is a question about the mechanism of action of indomethacin in treating patent ductus arteriosus PDA in a premature newborn. Indomethacin works by inhibiting the enzyme cyclooxygenase, which leads to decreased synthesis of prostaglandins. Prostaglandins, especially PGE2, help maintain the patency of the ductus arteriosus in utero. After birth, the ductus normally closes within 72 hours due to increased oxygen tension. In premature infants, the ductus may fail to close leading to PDA. By inhibiting prostaglandin synthesis, indomethacin promotes closure of the PDA.C: Decreased blood flow in the vasa vasorum of the ductus arteriosus 