<prompt> Please answer with one of the option in the bracket. Write reasoning in between . Write answer in between .Q:Your colleague has been reading the literature on beta-carotene supplementation and the risk of heart disease. She thinks they may share a clinically relevant association and would like to submit an editorial to a top journal. Upon final literature review, she discovers a newly published study that refutes any association between beta-carotene and heart disease. Your colleague is upset; you suggest that she, instead, mathematically pool the results from all of the studies on this topic and publish the findings. What type of study design are you recommending to your colleague?? A: Randomized control trial, B: Systematic review, C: Case-cohort study, D: Meta-analysis, E: Cross-sectional study,  <response>: This is a question asking about the appropriate study design to summarize the findings across multiple studies on the association between beta-carotene supplementation and heart disease risk. The key points are that there are multiple existing studies with conflicting results, and the goal is to mathematically combine the results to come to an overall conclusion. This describes a meta-analysis, which is a quantitative statistical analysis that pools the results of multiple studies. D: Meta-analysis 