<prompt> Please answer with one of the option in the bracket. Write reasoning in between . Write answer in between .Q:A 58-year-old male undergoes a surveillance colonoscopy in which a 2 cm adenoma is identified and removed. Had this adenoma not been excised, the patient would have been at risk of progression to carcinoma. Which of the following is the final mutational step in the progression from adenoma to carcinoma?? A: K-ras mutation, B: COX-2 overexpression, C: p53 inactivation, D: APC mutation, E: SMAD 24 loss,  <response>: This is asking about the final mutational step in the progression from colon adenoma to carcinoma. Adenomas are benign tumors that can progress to cancer through accumulation of mutations. The key steps in this progression are:1 APC mutation - leads to initial adenoma formation2 K-RAS mutation - promotes adenoma growth3 p53 inactivation - allows progression to carcinoma4 SMAD 24 loss and COX-2 overexpression occur but are not the final steps.So the final mutational step is inactivation of the p53 tumor suppressor gene.C: p53 inactivation 