<prompt> Please answer with one of the option in the bracket. Write reasoning in between . Write answer in between .Q:A 35-year-old woman gravida 2, para 1, comes to the physician for her first prenatal visit. Pregnancy and delivery of her first child were uncomplicated. She is not sure about the date of her last menstrual period. Pelvic examination shows a uterus consistent in size with a 10-week gestation. An ultrasound examination confirms the gestational age and shows one fetus with no indication of multiple gestations. During counseling on pregnancy risks and possible screening and diagnostic tests, the patient states she would like to undergo screening for Down syndrome. She would prefer immediate and secure screening with a low risk to herself and the fetus. Which of the following is the most appropriate next step in management at this time?? A: Maternal serum α-fetoprotein, human chorionic gonadotropin, unconjugated estriol, and inhibin A, B: Amniocentesis, C: Nuchal translucency, pregnancy-associated plasma protein-A, human chorionic gonadotropin, D: Cell-free fetal DNA testing, E: Chorionic villus sampling,  <response>: This is a question asking about the most appropriate screening test for Down syndrome in a 35-year-old pregnant woman who is currently at 10 weeks gestation. The key points in the stem are the patients age of 35, gestational age of 10 weeks, desire for screening with low risk, and secure and immediate results.The answer choices include different types of screening and diagnostic tests for Down syndrome. Choice A describes the quad screen, which is done in the second trimester and would not provide immediate results. Choice B, amniocentesis, and Choice E, chorionic villus sampling, are invasive diagnostic tests that have a risk of miscarriage so do not meet the patients desire for low risk. Choice C describes first trimester screening, which includes nuchal translucency ultrasound along with blood tests for pregnancy-associated plasma protein-A and human chorionic gonadotropin. This can provide immediate screening results with low risk. Choice D, cell-free fetal DNA testing, is a type of noninvasive prenatal screening that can be done early in pregnancy and provide very secure results with virtually no risk.D: Cell-free fetal DNA testing 