<prompt> Please answer with one of the option in the bracket. Write reasoning in between . Write answer in between .Q:Pancreatic islets were isolated from a healthy, non-diabetic donor to perform an experiment to look at insulin secretion inhibition. Compounds would be added to separate wells containing the islets bathed in a high glucose solution for one hour. After one hour, the supernatant would be collected, and the insulin content would be measured with an enzyme-linked immunosorbent assay ELISA. Which of the following compounds would result in the least insulin secretion when added to the islets?? A: Dobutamine, B: Isoproterenol, C: Tolbutamide, D: Clonidine, E: Glyburide,  <response>: This is a question about the effects of different compounds on insulin secretion from pancreatic islets. The goal is to determine which compound would result in the least insulin secretion when added to isolated pancreatic islets in high glucose. Dobutamine and isoproterenol are beta-adrenergic agonists that would stimulate insulin secretion. Tolbutamide and glyburide are sulfonylureas that bind to sulfonylurea receptors on beta cells and stimulate insulin secretion. Clonidine is an alpha-2 adrenergic agonist that inhibits insulin secretion by hyperpolarizing beta cells and preventing calcium influx. Therefore, clonidine would be expected to result in the least insulin secretion compared to the other answer choices.D: Clonidine 