<prompt> Please answer with one of the option in the bracket. Write reasoning in between . Write answer in between .Q:A 52-year-old man presents to his physician after his routine screening revealed that he has elevated liver enzymes. He complains of occasional headaches during the past year, but otherwise feels well. The patient reports that he was involved in a serious car accident in the 1980s. He does not smoke or drink alcohol. He has no history of illicit intravenous drug use. He does not currently take any medications and has no known allergies. His father had a history of alcoholism and died of liver cancer. The patient appears thin. His temperature is 37.8C 100F, pulse is 100min, and blood pressure is 11070 mm Hg. The physical examination reveals no abnormalities. The laboratory test results show the following:Complete blood countHemoglobin 14 gdLLeukocyte count 10,000mm3Platelet count 146,000mm3Comprehensive metabolic profileGlucose 150 mgdLAlbumin 3.2 gdLTotal bilirubin 1.5 mgdLAlkaline phosphatase 75 IULAST 95 IULALT 73 IULOther lab testsHIV negativeHepatitis B surface antigen negativeHepatitis C antibody positiveHCV RNA positiveHCV genotype 1A liver biopsy is performed and shows mononuclear infiltrates localized to portal tracts that reveal periportal hepatocyte necrosis. Which of the following is the most appropriate next step in management?? A: Interferon and ribavirin therapy, B: Peginterferon alpha therapy, C: Sofosbuvir and ledipasvir therapy, D: Tenofovir and entecavir therapy, E: Tenofovir and velpatasvir therapy,  <response>: This is a clinical case about a 52-year-old man with elevated liver enzymes and a history of hepatitis C infection. The key findings in the case are:- Elevated liver enzymes on routine screening - History of hepatitis C infection positive HCV antibody and RNA, genotype 1- Liver biopsy showing changes consistent with hepatitis C periportal inflammation and necrosis- No other causes identified no alcohol use, normal iron studies, negative hepatitis B and HIVThe question is asking for the most appropriate next step in management. Based on the patients history, physical exam and lab findings, he most likely has chronic hepatitis C infection causing his abnormal liver tests. The biopsy confirms this diagnosis. The provided answer choices are different antiviral treatment regimens for hepatitis C. Since the patient has genotype 1 hepatitis C, the most effective regimen would be a direct-acting antiviral combination that covers this genotype. Sofosbuvir and ledipasvir would be the best choice.Interferon, peginterferon, and the other antivirals listed are either older, less effective regimens or used for other types of viral hepatitis. Sofosbuvir and ledipasvir specifically target genotype 1 hepatitis C.C: Sofosbuvir and ledipasvir therapy 