<prompt> Please answer with one of the option in the bracket. Write reasoning in between . Write answer in between .Q:A 3-year-old boy is brought to the physician because of a 1-week history of yellowish discoloration of his eyes and skin. He has had generalized fatigue and mild shortness of breath for the past month. Three weeks ago, he was treated for a urinary tract infection with antibiotics. His father underwent a splenectomy during childhood. Examination shows pale conjunctivae and jaundice. The abdomen is soft and nontender; there is nontender splenomegaly. Laboratory studies show:Hemoglobin 9.1 gdLMean corpuscular volume 89 μm3Mean corpuscular hemoglobin 32 pgcellMean corpuscular hemoglobin concentration 37.8 HbcellLeukocyte count 7800mm3Platelet count 245,000mm3Red cell distribution width 22.8 N1315SerumBilirubinTotal 13.8 mgdLDirect 1.9 mgdLLactate dehydrogenase 450 ULWhich of the following is the most likely pathophysiology of these findings?? A: Increased hemoglobin S, B: Decreased spectrin in the RBC membrane, C: Deficient glucose-6 phosphate dehydrogenase, D: Decreased synthesis of alpha chains of hemoglobin, E: Deficiency of pyruvate kinase,  <response>: This is a clinical case scenario about a 3-year-old boy with jaundice, fatigue, shortness of breath, splenomegaly, and abnormal lab results indicating hemolytic anemia. The key findings are jaundice, splenomegaly, elevated bilirubin, elevated LDH, low hemoglobin, and high RDW, which point towards a diagnosis of hemolytic anemia. The history of the father having a splenectomy during childhood raises suspicion for an inherited red blood cell disorder. The choices describe different causes of hemolytic anemia. Based on the clinical and lab findings, the most likely diagnosis is an inherited red cell membrane disorder causing increased red cell fragility and hemolysis, such as hereditary spherocytosis.B: Decreased spectrin in the RBC membrane 