<prompt> Please answer with one of the option in the bracket. Write reasoning in between . Write answer in between .Q:Seven days after undergoing bilateral total knee arthroplasty, a 65-year-old man comes to the physician with a dark discoloration and blisters on his abdomen. Current medications include simvastatin, aspirin, and low molecular weight heparin. His vital signs are within normal limits. Examination of the skin shows multiple coalescing blisters with areas of necrosis around the umbilicus. Laboratory studies show a platelet count of 32,000mm3. Which of the following is the most likely underlying cause of this patients symptoms?? A: Anti-desmoglein antibody formation, B: Deficiency in ADAMTS13 activity, C: Antibody formation against heparin-PF4 complex, D: Antibody-platelet antigen complex formation, E: Decreased production of GpIb,  <response>: This is a clinical vignette describing a patient who developed a skin rash and low platelet count after undergoing knee surgery and being placed on anticoagulation with heparin. The key findings are blistering skin lesions, areas of skin necrosis, and thrombocytopenia occurring in the setting of recent surgery and heparin therapy. The differential diagnosis includes:- Heparin-induced thrombocytopenia HIT: This is the most likely diagnosis given the timeline of knee surgery, heparin exposure, and subsequent development of thrombocytopenia. HIT is caused by antibody formation against the heparin-PF4 complex.- Disseminated intravascular coagulation DIC: Less likely given normal coagulation studies. DIC can cause thrombocytopenia but blistering skin lesions are not typical.- Adverse reaction to simvastatin or aspirin: Unlikely as these reactions do not cause thrombocytopenia.- Antibody-mediated platelet destruction: Less likely and would not be expected in temporal relation to heparin exposure.Based on the clinical picture of thrombocytopenia and skin necrosis following heparin exposure, the most likely diagnosis is HIT secondary to antibodies against the heparin-PF4 complex.C: Antibody formation against heparin-PF4 complex 