<prompt> Please answer with one of the option in the bracket. Write reasoning in between . Write answer in between .Q:A 35-year-old male presents to his primary care physician with complaints of seasonal allergies. He has been using intranasal vasoconstrictors several times per day for several weeks. What is a likely sequela of the chronic use of topical nasal decongestants?? A: Epistaxis, B: Hypertension, C: Permanent loss of smell, D: Persistent nasal crusting, E: Persistent congestion,  <response>: This is asking about the potential side effects of chronic use of topical nasal decongestants like oxymetazoline. The key piece of information is that the patient has been using these medications several times per day for several weeks. The main concern with prolonged frequent use of these medications is rebound nasal congestion or rhinitis medicamentosa. This occurs because the medications cause vasoconstriction which decreases swelling, but with chronic use the blood vessels get overly sensitive and swell more when the medication wears off. This leads to a cycle of congestion when the medication wears off, use of more medication, and progressively worse rebound congestion.Of the choices, Persistent nasal congestion best matches this potential side effect of chronic topical nasal decongestant use. The other options do not reflect known sequela of these medications.E: Persistent congestion 