<prompt> Please answer with one of the option in the bracket. Write reasoning in between . Write answer in between .Q:A 75-year-old female comes to the physicians office with complaints of right lower quadrant pain. She has been experiencing these symptoms for the last 6 months and they have progressively gotten worse. An ultrasound reveals a large ovarian mass and abdominal and pelvic CT reveals no metastases. Her serum levels of CA-125 are elevated and the biopsy reveals the primary neoplasm as ovarian in origin. Her cancer is characterized as invasive carcinoma without metastasis. Which of the following cellular changes is consistent with this diagnosis?? A: Appropriate basal to apical differentiation, B: Intact basement membrane, C: Loss of E-cadherin, D: Seeding via capillaries, E: Increased proliferation of cells with preservation of size and shape,  <response>: This is a medical question asking about the cellular changes consistent with a diagnosis of invasive ovarian carcinoma without metastasis in a 75-year-old female. Based on the information provided, she has a large ovarian mass, elevated CA-125 levels, and a biopsy confirming primary ovarian invasive carcinoma, but no evidence of metastasis on imaging. The key finding is invasive carcinoma without metastasis. Invasive carcinomas show loss of normal tissue architecture and basement membrane integrity, allowing cancer cells to invade into surrounding tissues. Metastasis has not yet occurred, so we would not expect to see seeding via capillaries. The remaining choices describe normal tissue architecture and regulated proliferation, which would not be consistent with invasive carcinoma.C: Loss of E-cadherin 