<prompt> Please answer with one of the option in the bracket. Write reasoning in between . Write answer in between .Q:A 70-year-old woman comes to the physician because of a 4-month history of fatigue, worsening swelling of her ankles, and a 5-kg 11-lb weight gain. Neurologic examination shows diminished two-point discrimination in her fingers. Laboratory studies show a hemoglobin A1c concentration of 9.2 and a creatinine concentration of 1.3 mgdL. Urine dipstick shows heavy proteinuria. A biopsy specimen of this patients kidney is most likely to show which of the following?? A: Split glomerular basement membrane, B: Immune complex deposition, C: Interstitial inflammation, D: Wire looping of capillaries, E: Nodular glomerulosclerosis,  <response>: This is a medical question asking about the most likely kidney biopsy finding in a 70-year-old woman with symptoms and lab results consistent with diabetic nephropathy. The key findings are long-standing diabetes elevated A1c, renal insufficiency elevated creatinine, and proteinuria on urinalysis. These indicate diabetic nephropathy as the most likely diagnosis. The choices describe various pathological findings on kidney biopsy. In diabetic nephropathy, the typical finding is nodular glomerulosclerosis due to accumulation of extracellular matrix proteins in the glomeruli.E: Nodular glomerulosclerosis 