<prompt> Please answer with one of the option in the bracket. Write reasoning in between . Write answer in between .Q:A 43-year-old man comes to the physician because of a swelling at the back of his left knee that he first noticed 2 months ago. The swelling is not painful, but he occasionally experiences pain at the back of his knee when he is standing for prolonged periods. He also reports mild stiffness of the knee when he wakes up in the morning that disappears after a few minutes of waking up and moving about. Examination shows no local calf tenderness, but forced dorsiflexion of the foot aggravates his knee pain. There is a 3-cm, mildly tender, fixed mass at the medial side of the left popliteal fossa. The mass is more prominent on extension and disappears upon flexion of the left knee. Which of the following is the strongest predisposing risk factor for this patients condition?? A: Purine-rich diet, B: Varicose veins, C: Mutation of coagulation factor V gene, D: Family history of multiple lipomatosis, E: History of meniscal tear,  <response>: This is a clinical vignette describing a 43-year-old man with a swelling behind his left knee and associated symptoms of morning stiffness and pain with prolonged standing. The key findings on exam are a mass in the popliteal fossa that changes in size with knee flexionextension. The question asks about the strongest predisposing risk factor for this condition. Based on the location and characteristics of the mass, this is most consistent with a Bakers cyst, which is a fluid-filled cyst that can form behind the knee in association with conditions that cause swelling and inflammation in the knee joint. The choices include dietary, vascular, genetic, and trauma-related factors. Of these, the strongest predisposing risk factor for a Bakers cyst is a history of injury or structural damage to the knee joint that causes inflammation, such as a meniscal tear. This explains the chronic swelling and inflammation that can lead to cyst formation.E: History of meniscal tear 