<prompt> Please answer with one of the option in the bracket. Write reasoning in between . Write answer in between .Q:A 58-year-old male presents to the clinic for a follow-up visit. He takes metformin every day and says that he is compliant with his medication but can not control his diet. Three months prior, his HbA1c was 8.2 when he was started on metformin. He does not have any complaints on this visit. His temperature is 37C 98.6F, respirations are 15min, pulse is 67min and blood pressure is 12288 mm Hg. His BMI is 33. Physical examination is within normal limits. Blood is drawn for laboratory tests and the results are given below:Fasting blood glucose 150 mgdLGlycated hemoglobin HbA1c 7.2 Serum Creatinine 1.1 mgdLBUN 12 mgdLThe physician wants to initiate another medication for his blood glucose control, specifically one that does not carry a risk of weight gain. Addition of which of the following drugs would be most suitable for this patient?? A: Glimepiride, B: Rosiglitazone, C: Pioglitazone, D: Sitagliptin, E: Glyburide,  <response>: This is a patient with type 2 diabetes mellitus who is currently taking metformin but still has suboptimal glycemic control based on his HbA1c of 7.2. He is overweight with a BMI of 33. His physician wants to add a second medication to improve his blood glucose control that does not cause weight gain. The choices given are all oral anti-diabetic medications. Glimepiride, glyburide, pioglitazone and rosiglitazone can all cause weight gain. Sitagliptin is a DPP-4 inhibitor that does not typically cause weight gain.Based on the information provided, the best answer is sitagliptin as it can improve blood glucose control without weight gain.D: Sitagliptin 