<prompt> Please answer with one of the option in the bracket. Write reasoning in between . Write answer in between .Q:A 57-year-old man comes to the physician because of a 4-week history of constipation, episodic bloody stools, progressive fatigue, and a 5-kg 10.2-lb weight loss. Digital rectal examination shows a hard, 1.5-cm rectal mass. A biopsy confirms the diagnosis of colorectal carcinoma. The patient begins treatment with a combination chemotherapy regimen that includes a drug that is also used in the treatment of wet age-related macular degeneration. This drug most likely acts by inhibiting which of the following substances?? A: Fibroblast growth factor, B: Epidermal growth factor, C: Metalloproteinase, D: Interferon-alpha, E: Vascular endothelial growth factor,  <response>: This is a medical question asking about the mechanism of action of a chemotherapy drug that is also used to treat wet age-related macular degeneration. Based on the information provided, this drug likely inhibits angiogenesis or growth of new blood vessels. Age-related macular degeneration and cancer growthmetastasis depend on angiogenesis. Of the answer choices provided, vascular endothelial growth factor VEGF is responsible for promoting angiogenesis. Therefore, the drug most likely acts by inhibiting VEGF.E: Vascular endothelial growth factor 