<prompt> Please answer with one of the option in the bracket. Write reasoning in between . Write answer in between .Q:An 18-year old college freshman presents to his university clinic because he has not been feeling well for the past two weeks. He has had a persistent headache, occasional cough, and chills without rigors. The patients vital signs are normal and physical exam is unremarkable. His radiograph shows patchy interstitial lung infiltrates and he is diagnosed with atypical pneumonia. The patient is prescribed azithromycin and takes his medication as instructed. Despite adherence to his drug regimen, he returns to the clinic one week later because his symptoms have not improved. The organism responsible for this infection is likely resistant to azithromycin through which mechanism?? A: Presence of a beta-lactamase, B: Insertion of drug efflux pumps, C: Decreased binding to RNA polymerase, D: Mutation in topoisomerase II, E: Methylation of ribosomal binding site,  <response>: This is a medical question asking about the mechanism of antibiotic resistance in a case of atypical pneumonia not responding to azithromycin treatment. The question stem provides details about an 18-year old with persistent symptoms of atypical pneumonia despite taking azithromycin as prescribed. The choices list different potential mechanisms of antibiotic resistance. To answer the question, I need to consider which mechanism would most likely explain resistance to azithromycin in this clinical scenario involving atypical pneumonia likely caused by an intracellular organism like Mycoplasma or Chlamydia.E: Methylation of ribosomal binding site 