<prompt> Please answer with one of the option in the bracket. Write reasoning in between . Write answer in between .Q:A 73-year-old man presents to your office accompanied by his wife. He has been experiencing a tremor in his right hand for the last several months that seems to be worsening. He does not have any other complaints and says hes fine. His wife thinks that he has also had more difficulty walking. His history is significant for hypertension and an ischemic stroke of the right middle cerebral artery 2 years ago. His medications include hydrochlorothiazide and daily aspirin. On physical exam you note that the patient speaks with a soft voice and has decreased facial expressions. He has a resting tremor that is worse on the right side. He has increased resistance to passive movement when you flex and extend his relaxed wrist. He has 55 strength bilaterally. Neuronal degeneration in which of the following locations is most likely responsible for the progression of this disease?? A: Substantia nigra pars compacta, B: Frontotemporal lobe, C: Subthalamic nucleus, D: Caudate and putamen, E: Vermis,  <response>: Based on the description in the question stem, this patient likely has Parkinsons disease. The key findings are a unilateral resting tremor that is worsening over time, decreased facial expressions, soft voice, and increased resistance to passive movement of the wrist rigidity. Parkinsons disease is caused by degeneration of dopaminergic neurons in the substantia nigra pars compacta. This leads to reduced dopamine levels in the striatum caudate and putamen, which causes the motor symptoms of Parkinsons disease. The other answer choices do not match the typical neuroanatomic pathology seen in Parkinsons.A: Substantia nigra pars compacta 