<prompt> Please answer with one of the option in the bracket. Write reasoning in between . Write answer in between .Q:A 45-year-old male presents to your office following a diagnosis of an autosomal dominant disease. He has started therapy and has a strong family support system. He endorses a decrease in appetite over the last two weeks that he attributes to sadness surrounding his diagnosis and a depressed mood but denies any suicidal ideation. He continues to enjoy working in the yard and playing with his children. On physical examination you notice involuntary quick jerky movements of his hands and feet. Which of the following would you expect to see in this patient?? A: Caudate overactivity, B: Caudate and putamen atrophy, C: Depigmentation of the substantia nigra pars compacta, D: Atrophy of the subthalamic nucleus, E: Lesion in the vermis,  <response>: This is a clinical vignette describing a 45-year-old male with an autosomal dominant disease characterized by involuntary movements, decreased appetite and depressed mood. The key findings are the autosomal dominant inheritance, involuntary quick jerky movements of the hands and feet, and lack of suicidal ideation or psychosis. This clinical presentation is most consistent with Huntingtons disease. Huntingtons is an autosomal dominant neurodegenerative disorder caused by trinucleotide repeat expansion in the HTT gene on chromosome 4. It classically presents with chorea involuntary dance-like movements, as well as psychiatric disturbances and cognitive decline later in the disease. The pathophysiology involves degeneration of the caudate and putamen, which are parts of the basal ganglia that control voluntary movement. B: Caudate and putamen atrophy 