<prompt> Please answer with one of the option in the bracket. Write reasoning in between . Write answer in between .Q:A 62-year-old woman with a history of hypertension, hyperlipidemia, and rheumatoid arthritis presents for evaluation of elevated serum liver chemistries. She has had three months of intense, unremitting itching. Current medications include chlorthalidone, atorvastatin, and ibuprofen. Physical exam is unremarkable. Laboratory studies show aspartate aminotransferase AST 42 unitsL, alanine aminotransferase ALT 39 unitsL, alkaline phosphatase 790 unitsL, total bilirubin 0.8 mgdL, and antimitochondrial antibody titer 1:80. What do you expect to see on liver biopsy?? A: Intrahepatic and extra hepatic bile duct destruction, B: Intrahepatic bile duct destruction, C: Lymphoplasmacytic and eosinophilic infiltration of portal tracts, D: Granulomas in portal tracts, E: Bile plugging of hepatocytes and bile ducts,  <response>: This is a clinical vignette describing a 62-year-old woman with elevated liver enzymes and pruritus. Key findings include elevated alkaline phosphatase and antimitochondrial antibody titers. The history, labs, and antibody profile are classic for primary biliary cholangitis PBC. PBC is characterized by immune-mediated destruction of intrahepatic bile ducts leading to cholestasis. Liver biopsy would be expected to show lymphocytic infiltration and destruction of interlobular bile ducts.B: Intrahepatic bile duct destruction 