<prompt> Please answer with one of the option in the bracket. Write reasoning in between . Write answer in between .Q:A 19-year-old man comes to the physician for evaluation of night sweats, pruritus, and enlarging masses in his right axilla and supraclavicular area for 2 weeks. Physical examination shows painless, rubbery lymphadenopathy in the right axillary, supraclavicular, and submental regions. An excisional biopsy of an axillary node is performed. If present, which of the following features would be most concerning for a neoplastic process?? A: Polyclonal proliferation of lymphocytes with a single nucleus, B: Preponderance of lymphocytes with a single immunoglobulin variable domain allele, C: Positive staining of the paracortex for cluster of differentiation 8, D: Diffuse mitotic activity in secondary follicles, E: Predominance of histiocytes in the medullary sinuses,  <response>: This is a question about concerning features for neoplastic processes in lymph node biopsy findings. The key information in the stem is that a 19-year-old man has enlarging masses and painless lymphadenopathy, and a lymph node biopsy was performed. The choices describe different histopathological findings. Choice A describes a reactive, polyclonal proliferation which would not be concerning for malignancy. Choice B describes monoclonal proliferation and immunoglobulin light chain restriction, which can be seen in some lymphomas and would be concerning. Choice C describes a benign finding of T cells in the paracortex. Choice D describes increased mitotic activity, which can be seen in malignant processes. Choice E describes increased histiocytes, which can occur reactively and would not necessarily indicate malignancy.B: Preponderance of lymphocytes with a single immunoglobulin variable domain allele 