<prompt> Please answer with one of the option in the bracket. Write reasoning in between . Write answer in between .Q:An otherwise healthy 49-year-old man presents to his primary care physician for follow-up for a high HbA1C. 3 months ago, his HbA1c was 8.9 on routine screening. Today, after lifestyle modifications, it is 8.1 and his serum glucose is 270 mgdL. Which of the following is the best initial therapy for this patients condition?? A: Metformin, B: Metformin added to basal insulin, C: Metformin added to an insulin secretagogue, D: Metformin added to a glucagon-like peptide 1 GLP-1 agonist, E: Metformin added to a dipeptidyl peptidase-4 DPP-4 inhibitor,  <response>: This patient has type 2 diabetes mellitus based on his elevated HbA1c. His HbA1c has improved slightly after 3 months of lifestyle modifications, but is still too high at 8.1. His serum glucose is also elevated at 270 mgdL. The best initial pharmacologic therapy for a newly diagnosed type 2 diabetic is metformin. It is recommended as first-line therapy by the American Diabetes Association and other major guidelines. Metformin works by reducing hepatic glucose production and improving insulin sensitivity. Adding other agents like insulin, sulfonylureas, GLP-1 agonists or DPP-4 inhibitors may be considered if metformin alone does not achieve glycemic control. However, metformin monotherapy is the preferred initial therapy in this otherwise healthy patient.A: Metformin 