<prompt> Please answer with one of the option in the bracket. Write reasoning in between . Write answer in between .Q:A 13-year-old girl is referred to an oral surgeon after complaining of tooth pain, especially in the upper jaw. A review of her medical history reveals status post-surgical repair of a patent ductus arteriosus when she was 6 years old. At the clinic, her temperature is 37.0oC 98.6F, pulse is 90min, respirations are 18min, and blood pressure is 11078 mm Hg. On physical examination, her height is 157.5 cm 5 ft 2 in, her weight is 50 kg 110 lb and her arms seem disproportionately long for her trunk. She also has arachnodactyly and moderate joint laxity. Intraoral examination reveals crowded teeth and a high arched palate. Which of the following protein is most likely defective in this condition?? A: Caveolin and the sarcoglycan proteins, B: α2-laminin merosin, C: Emerin, D: Lamin A, E: Fibrillin-1,  <response>: This is a clinical vignette describing a 13-year-old girl with a history of patent ductus arteriosus repair who now presents with tooth pain and crowded teeth. On exam she has arachnodactyly, joint laxity, and a high arched palate. These findings are classic for Marfan syndrome, which is caused by mutations in the fibrillin-1 gene. Fibrillin-1 is an extracellular matrix glycoprotein that is a major component of microfibrils. Defective fibrillin-1 leads to weakened connective tissue and the constellation of skeletal, ocular, and cardiovascular abnormalities seen in Marfan syndrome.E: Fibrillin-1 