<prompt> Please answer with one of the option in the bracket. Write reasoning in between . Write answer in between .Q:A 33-year-old female presents to her primary care physician complaining of heat intolerance and difficulty sleeping over a one month period. She also reports that she has lost 10 pounds despite no changes in her diet or exercise pattern. More recently, she has developed occasional unprovoked chest pain and palpitations. Physical examination reveals a nontender, mildly enlarged thyroid gland. Her patellar reflexes are 3 bilaterally. Her temperature is 99F 37.2C, blood pressure is 13585 mmHg, pulse is 105min, and respirations are 18min. Laboratory analysis is notable for decreased TSH. Which of the following pathophysiologic mechanisms contributed to the cardiovascular symptoms seen in this patient?? A: Increased numbers of a1-adrenergic receptors, B: Decreased numbers of a1-adrenergic receptors, C: Decreased numbers of a2-adrenergic receptors, D: Decreased sensitivity of ß2-adrenergic receptors, E: Increased sensitivity of ß1-adrenergic receptors,  <response>: This is a question about hyperthyroidism. The patient presents with symptoms of hyperthyroidism like heat intolerance, weight loss, enlarged thyroid, elevated temperature and pulse. The decreased TSH also indicates hyperthyroidism. The question asks about the mechanism contributing to the cardiovascular symptoms seen in this patient. The cardiovascular symptoms are occasional chest pain and palpitations. In hyperthyroidism, there is increased sensitivity of β1-adrenergic receptors in the heart. This leads to increased heart rate and contractility, which can cause palpitations and chest pain.So the increased sensitivity of β1-adrenergic receptors is the pathophysiologic mechanism contributing to the patients cardiovascular symptoms.E: Increased sensitivity of ß1-adrenergic receptors 