<prompt> Please answer with one of the option in the bracket. Write reasoning in between . Write answer in between .Q:A 47-year-old man presents with a history of a frequent unpleasant crawling sensation in both of his legs accompanied by an urge to move his legs for the last 6 months. He continuously moves his legs to provide him with partial relief from the unpleasant feelings in his legs. The symptoms are especially severe during the night or while lying down in bed after returning from work. These symptoms occur 35 days per week. He also complains of significant daytime fatigue and sleep disturbances on most days of the week. He is advised to take a polysomnography test, which reveals periodic limb movements PLMs during his sleep. Which of the following conditions is most associated with secondary restless legs syndrome?? A: Iron deficiency anemia, B: Pulmonary tuberculosis, C: Zinc deficiency, D: Vitamin B3 deficiency, E: Liver failure,  <response>: This is a clinical vignette describing a patient with symptoms of restless legs syndrome RLS. The key features are an unpleasant crawling sensation in the legs, urge to move the legs, temporary relief with movement, and worsening of symptoms at restnighttime. Polysomnography showing periodic limb movements further supports the diagnosis of RLS. The question asks which condition is most associated with secondary or acquired RLS. Iron deficiency anemia is the most common cause of secondary RLS, so this is likely the correct answer. The other answer choices do not have a strong association with secondary RLS based on my medical knowledge.A: Iron deficiency anemia 