<prompt> Please answer with one of the option in the bracket. Write reasoning in between . Write answer in between .Q:A 50-year-old female presents to her physician with vesicles and tense blisters across her chest, arms, and the back of her shoulders. Physical examination reveals that blistering is not present in her oral mucosa, and the epidermis does not separate upon light stroking of the skin. The patient most likely suffers from a hypersensitivity reaction located:? A: Linearly along the epidermal basement membrane, B: In net-like patterns around epidermal cells, C: In granular deposits at the tips of dermal papillae, D: In fat cells beneath the skin, E: In nuclei within epidermal cells,  <response>: This is a question about the location of a hypersensitivity reaction in a patient with vesicles and blisters on her chest, arms, and shoulders. The lack of oral mucosal involvement and lack of Nikolskys sign on physical exam make this most consistent with bullous pemphigoid, an autoimmune blistering disease. In bullous pemphigoid, antibodies are directed against hemidesmosomes linking the epidermal basement membrane to the underlying dermis. This causes subepidermal blistering. A: Linearly along the epidermal basement membrane 