<prompt> Please answer with one of the option in the bracket. Write reasoning in between . Write answer in between .Q:A researcher is investigating the risk of symptomatic intracerebral hemorrhage associated with tissue plasminogen activator tPA treatment in severe ischemic stroke. The outcomes of a large randomized controlled trial of ischemic stroke patients, some of whom were randomized to tPA, is shown:Symptomatic intracerebral hemorrhage No symptomatic intracerebral hemorrhageReceived tPA 12 188Did not receive tPA 25 475Based on this data, how many patients with severe ischemic stroke would need to be treated with tPA, on average, to contribute to one case of symptomatic intracerebral hemorrhage?? A: 6, B: 0.01, C: 13, D: 1.2, E: 100,  <response>: To answer this question, we need to calculate the number needed to harm NNH from the data provided in the table. The NNH tells us how many patients need to receive a treatment for one additional patient to experience an adverse event. The formula is: NNH 1 Risk of harm with treatment - Risk of harm without treatmentThe risk of harm with tPA is 12200 0.06 The risk of harm without tPA is 25500 0.05Plugging this into the formula:NNH 1 0.06 - 0.05 1 0.01 100E: 100 