<prompt> Please answer with one of the option in the bracket. Write reasoning in between . Write answer in between .Q:An investigator studying immune-mediated pulmonary damage performs an autopsy on a bilateral lung transplant recipient who died of hypercapnic respiratory failure. The patient underwent lung transplantation for idiopathic pulmonary fibrosis. Microscopic examination of the lung shows diffuse eosinophilic scarring of the terminal and respiratory bronchioles and near-complete luminal obliteration by polypoidal plugs of granulation tissue. Examination of the skin shows no abnormalities. The findings in this patient are most consistent with which of the following conditions?? A: Transfusion-related acute lung injury, B: Recurrence of primary disease, C: Chronic graft rejection, D: Acute graft-versus-host disease, E: Acute graft rejection,  <response>: This is a medical question asking to identify the condition most consistent with the histological findings described in a lung transplant recipient. The key findings are eosinophilic scarring of the bronchioles with near complete luminal obliteration by granulation tissue plugs. This indicates a chronic inflammatory process affecting the small airways of the transplanted lung. The choices given include transfusion reaction, recurrence of original disease, chronic rejection, acute GVHD, and acute rejection. Recurrence of the original disease IPF would not cause this bronchiole-centered pattern. Acute rejection and acute GVHD would not lead to extensive scarring and granulation tissue. Therefore, the findings are most consistent with chronic lung allograft rejection.C: Chronic graft rejection 