<prompt> Please answer with one of the option in the bracket. Write reasoning in between . Write answer in between .Q:A 32-year-old man presents to an outpatient clinic for tuberculosis prophylaxis before leaving for a trip to Asia, where tuberculosis is endemic. The Mantoux test is positive, but the chest X-ray and AFB sputum culture are negative. He was started on isoniazid. What is the most likely mechanism of resistance to isoniazid?? A: Mutations in katG, B: Reduction of drug binding to RNA polymerase, C: Plasmid-mediated resistance, D: Methylation of the RNA binding site, E: Increased efflux from the cell,  <response>: This is a question about the mechanism of resistance to the tuberculosis drug isoniazid. The patient has a positive Mantoux test indicating tuberculosis infection, but negative chest X-ray and culture showing no active disease. He was started on isoniazid for prophylaxis before traveling somewhere with high tuberculosis prevalence. The question asks about the most likely mechanism of resistance to isoniazid.Choice A mentions mutations in the katG gene, which encodes an enzyme that activates isoniazid. Mutations in katG are a common mechanism of isoniazid resistance. Choices B-D describe mechanisms of resistance to other antibiotic classes not relevant to isoniazid. Choice E about increased efflux is a less common mechanism of isoniazid resistance. Based on this analysis, choice A seems most likely to be the right answer.A: Mutations in katG 