<prompt> Please answer with one of the option in the bracket. Write reasoning in between . Write answer in between .Q:A 23-year-old pregnant woman gravida 1, para 0 presents during her 16th week of pregnancy for a check-up. The course of her current pregnancy is unremarkable. She had normal results on the previous ultrasound examination. Her human chorionic gonadotropin hCG level measured at week 12 of pregnancy was 0.9 multiples of the normal median MoM. She is human immunodeficiency virus HIV, hepatitis B virus HBV, and hepatitis C virus HCV-negative. She undergoes a quadruple test which shows the following results:Serum alpha-fetoprotein LowUnconjugated estriol LowBeta-hCG HighInhibin A HighThe risk of which condition indicates these results?? A: Trisomy 21, B: Trisomy 18, C: Neural tube defect, D: Congenital toxoplasmosis, E: Trophoblastic disease,  <response>: This is a question about interpreting quadruple test results during pregnancy. The key findings in the question stem are:- The patient is 16 weeks pregnant - Previous ultrasound was normal- hCG at 12 weeks was normal 0.9 MoM- She is HIV, HBV, and HCV negative- Quadruple screen shows: - AFP: Low - uE3: Low - hCG: High - Inhibin A: HighThe quadruple screen looks at 4 markers to estimate risk of certain fetal abnormalities. Low AFP and low uE3 along with high hCG and inhibin A are classic findings for trisomy 21 Down syndrome. Trisomy 18 would show low AFP but normal hCG. Neural tube defects would have elevated AFP. Congenital toxoplasmosis and trophoblastic disease would not have this pattern of biomarker results.A: Trisomy 21 