<prompt> Please answer with one of the option in the bracket. Write reasoning in between . Write answer in between .Q:A 40-year-old woman comes to the physician for a 2-month history of chest pain and heartburn after meals. The patient reports that the pain is worse at night and especially when lying down. She has a history of Raynauds disease treated with nifedipine. There is no family history of serious illness. She emigrated to the US from Nigeria 5 years ago. She does not smoke or drink alcohol. Vital signs are within normal limits. Cardiopulmonary examination shows no abnormalities. Thickening and hardening of the skin is seen on the hands and face. There are several firm, white nodules on the elbows and fingertips. Further evaluation of this patient is most likely to show which of the following findings?? A: Anti-RNA polymerase III antibodies, B: Anti-U1 RNP antibodies, C: Anticentromere antibodies, D: Anti-Scl-70 antibodies, E: Anti-dsDNA antibodies,  <response>: This is a clinical vignette describing a 40-year-old woman with a 2-month history of chest pain and heartburn after meals, worse at night and when lying down. She has a history of Raynauds disease and emigrated from Nigeria 5 years ago. On exam she has thickening and hardening of the skin on her hands and face, as well as firm white nodules on her elbows and fingertips. Based on the description, the most likely diagnosis is scleroderma, specifically the limited cutaneous subtype. The chest pain, Raynauds phenomenon, skin changes, and calcinosis are all classic features. Anti-centromere antibodies are positive in 70-80 of patients with limited cutaneous scleroderma, making them the most likely antibody finding in this patient.Anti-Scl-70 antibodies are associated with diffuse cutaneous scleroderma rather than the limited subtype described here. The other antibody choices are not typically seen in scleroderma.C: Anticentromere antibodies 