<prompt> Please answer with one of the option in the bracket. Write reasoning in between . Write answer in between .Q:A 70-year-old woman presents to her primary care doctor complaining of left knee pain. She states that she has noticed this more during the past several months after a fall at home. Previously, she was without pain and has no history of trauma to her knees. The patient states that the majority of her pain starts in the afternoon after she has been active for some time, and that the pain resolves with rest and over-the-counter analgesics. Aside from the left knee, she has no other symptoms and no other joint findings. On exam, her temperature is 98.8F 37.1C, blood pressure is 12476 mmHg, pulse is 70min, and respirations are 12min. The patient has no limitations in her range of motion and no changes in strength on motor testing. However, there is tenderness along the medial joint line. What finding is most likely seen in this patient?? A: Association with HLA-DR4, B: Heberden nodes, C: Increased synovial fluid, D: Joint pannus, E: Marginal sclerosis,  <response>: This is a question about knee pain in an elderly patient. The history and physical exam findings are consistent with osteoarthritis of the knee. The key findings are that the pain is worse with activity, improves with rest, there is tenderness along the medial joint line, and no limitations in range of motion or strength. Osteoarthritis is characterized by degeneration of articular cartilage and associated changes in the bone. On x-ray, findings would include joint space narrowing, subchondral sclerosis, osteophytes, and subchondral cysts. Choice A is incorrect because HLA-DR4 is associated with rheumatoid arthritis, not osteoarthritis. Choice B is incorrect because Heberden nodes bony enlargement of DIP joints are associated with osteoarthritis of the hands, not the knee. Choice C is incorrect because there is no evidence of effusion or increased synovial fluid on exam.Choice D is incorrect because pannus formation is seen in rheumatoid arthritis, not osteoarthritis. Choice E is correct because marginal osteophytes marginal sclerosis are characteristic radiographic findings in osteoarthritis.E: Marginal sclerosis 