<prompt> Please answer with one of the option in the bracket. Write reasoning in between . Write answer in between .Q:A 14-year-old girl with a history of severe persistent asthma presents to her pediatrician after a recent hospital discharge for asthma exacerbation. Her mother is concerned that her daughter continues to wheeze and cough multiple nights per week. She is also concerned that her daughter frequently uses the bathroom to urinate despite no recent change in her diet. She has allergies to pollen and shellfish, but her mother denies any recent exposure. The patients medications include albuterol, salmeterol, and both inhaled and oral prednisone. What alternative drug can the pediatrician recommend for this patient?? A: Natalizumab, B: Omalizumab, C: Imatinib, D: Nivolumab, E: Trastuzumab,  <response>: This is a clinical vignette about a 14-year-old girl with severe persistent asthma who continues to have asthma symptoms despite recent hospitalization and treatment with albuterol, salmeterol, inhaled and oral corticosteroids. She also has new onset increased urinary frequency. The question is asking for an alternative medication that can be used to treat her asthma.Choice A Natalizumab is used to treat multiple sclerosis and Crohns disease, not asthma, so this is incorrect. Choice B Omalizumab is a monoclonal antibody that binds IgE and is used as add-on therapy for allergic asthma, so this could be an appropriate alternative medication for this patient with severe persistent allergic asthma.Choice C Imatinib is a tyrosine kinase inhibitor used to treat certain cancers like chronic myeloid leukemia, not asthma, so this is incorrect.Choice D Nivolumab is an immune checkpoint inhibitor used for cancer treatment, not for asthma, so this is incorrect. Choice E Trastuzumab is a monoclonal antibody against HER2 and is used to treat HER2-positive breast cancers, not for asthma, so this is incorrect.B: Omalizumab 