<prompt> Please answer with one of the option in the bracket. Write reasoning in between . Write answer in between .Q:A 15-year-old girl is brought to the physician for her annual physical examination. Breast and pubic hair development began at the age of 12 years, but menses have not yet occurred. She is 160 cm 5 ft 3 in tall and weighs 54 kg 120 lb; BMI is 21 kgm2. Physical examination shows normal external genitalia. Breast and pubic hair development are Tanner stage 5. A pelvic ultrasound shows normal ovaries but an absent uterus. These findings are most likely due to a defect in which of the following embryologic structures?? A: Mesonephric duct, B: Genital tubercle, C: Gubernaculum, D: Urogenital sinus, E: Paramesonephric duct,  <response>: This is a question about identifying the embryologic structure most likely responsible for the clinical findings in a 15-year-old girl with normal pubertal development but absent uterus on pelvic ultrasound. The key findings are normal external genitalia, normal breast and pubic hair development, normal ovaries on ultrasound, but absent uterus. During embryonic development, the paramesonephric Müllerian ducts give rise to the uterus, fallopian tubes, and upper vagina in females. A defect in the paramesonephric ducts can lead to uterine agenesis or hypoplasia. The mesonephric Wolffian ducts give rise to male internal genitalia. Defects here would not explain uterine agenesis in a female. The genital tubercle gives rise to the external genitalia, which are normal in this patient. The gubernaculum guides testicular descent, which is not relevant in a female.The urogenital sinus gives rise to the lower vagina and vestibule. Defects here would not cause uterine agenesis.Therefore, a defect in the paramesonephric Müllerian ducts is the most likely cause of absent uterus in this patient.E: Paramesonephric duct 