<prompt> Please answer with one of the option in the bracket. Write reasoning in between . Write answer in between .Q:An obese, 66-year-old woman comes to the physician for a routine health maintenance examination. She feels well but is unhappy about being overweight. She reports that she feels out of breath when walking for more than one block and while climbing stairs. She has tried to lose weight for several years without success. She goes for a walk 3 times a week but she has difficulty following a low-calorie diet. During the past 12 months, she has had two urinary tract infections that were treated with fosfomycin. She has type 2 diabetes mellitus and osteoarthritis. Her only current medication is metformin. She has never smoked. She is 160 cm 5 ft 3 in tall and weighs 100 kg 220 lb; BMI is 39.1 kgm2. Vital signs are within normal limits. Physical examination shows cracking in both knees on passive movement. The remainder of the examination shows no abnormalities. Serum studies show an HbA1c of 9.5, and a fasting serum glucose concentration of 158 mgdL. An ECG shows no abnormalities. Which of the following is the most appropriate pharmacotherapy?? A: Topiramate, B: Exenatide, C: Pioglitazone, D: Acarbose, E: Phentermine,  <response>: This is a question about choosing appropriate pharmacotherapy for an obese, 66-year-old woman with type 2 diabetes mellitus. She has tried losing weight without success, has difficulty with a low-calorie diet, and is limited in her ability to exercise due to osteoarthritis. Her HbA1c is elevated at 9.5 indicating poor blood glucose control. The options given are different classes of medications used for weight loss and diabetes management. I need to consider her comorbidities and choose the medication that will best help her lose weight and improve her diabetes control.B: Exenatide 