<prompt> Pfupisa nyaya yacho: Paracetamol yezuva nezuva inogona kuwedzera ngozi yechirwere chomwoyo, sitiroko uye rufu rwomunguva pfupi, kuongorora kukuru kwakanyevera kudaro. Paracetamol yezuva nezuva inogona kuwedzera ngozi yechirwere chomwoyo, sitiroko norufu rwomunguva duku, kunonyevera kudaro fundo huru nhasi. Yakawana kuti varwere vakapiwa mishonga yakawanda yokurapa marwadzo kwenguva refu vaiva nomukana unosvika 63 muzana wokufa zvisingatarisirwi. Ngozi yokuva nehosha yemwoyo kana kuti sitiroko yakanga yakakwirira kusvika ku68 muzana uye pakanga pane mukana wakakura we50 muzana wokuva nechironda chepamuviri kana kuti kubuda ropa. Vanachiremba vanofunga kuti paracetamol yakachengeteka kupfuura aspirin, iyo inogona kukonzera kubuda ropa mudumbu, uye ibuprofen, iyo yakabatanidzwa nehosha yemwoyo uye sitiroko. Asi vanzveri veBritain avo vakatarira zvidzidzo zvaibatanidza varwere 666 000 vanoti ngozi dzingave dzakarerutswa uye vari kukumbira kuti kunzvera kukuru kuitwe pamusoro pokuchengeteka kwechirwere chacho. Vanofunga kuti paracetamol ingakonzera hosha kupfurikidza nokudzivisa kushanda kweenzyme iri mumuviri inonzi COX-2. Masayendisiti anobva kuLeeds Institute of Rheumatic and Musculoskeletal Medicine akaongorora ongororo sere dzaiva nemashoko pamusoro pevarwere vaitora paracetamol zuva nezuva kwemakore anosvika 14, nokuda kwezvirwere zvakadai sechirwere chemajoini uye kurwadziwa musana kwakakomba. Vakaongororawo varwere vaisashandisa mushonga wacho kakawanda kana kuti vaisatomboushandisa zvachose. Philip Conaghan, uyo akatungamirira kunzvera kwacho, akataura kuti kuvarwere vakawanda ngozi dzacho dzaiva duku zvikuru uye avo vakapiwa paracetamol kwenguva refu vaizova nezvirwere zvingangovauraya nokukurumidza. Nokuda kweichi chikonzero kwakanga kwakaoma kuva nechokwadi chokuti mirimo yakanga ichikonzera zvinetso. Asi purofesa wacho akawedzera kuti: Ndiri kunetseka kuti paracetamol yakapiwa yakawanda kwenguva yakareba inogona kuva nemigumisiro yatakanga tisati tamboona. Vakati varwere vanonyorerwa mishonga iyi kwenguva refu nokuda kwechirwere chearthritis kana kuti kurwadziwa kwetsandanyama uye kwemajoini vanofanira kutaura nachiremba wavo nezvemamwe marapirwo, akadai sokurovedza muviri. Rakabudiswa mumagazini inonzi Annals of the Rheumatic Diseases, ongororo yacho yakagumisa kuti: Nemhaka yokushandiswa kwazvo uye kuwanika kwazvo, nzira yakarongwa...  <response>: Avo vanoshandisa mushonga kwenguva refu vanosvika 63 vangangofa kamwe kamwe. Ngozi yavo yokuva nehosha yemwoyo kana kuti sitiroko yakakwirirawo kusvika ku68, inonyevera kudaro fundo. Vatsvakurudzi veBritain vari shure kwechidzidzo zvino vanokumbira kunzvera kukuru mumushonga. Vanoti mushonga wacho ungave uri kukonzera chirwere nokudzivisa enzyme inonzi COX-2. 