<prompt> Ihormone ipi isingadereri panguva yokutanga yokurara zvishoma, cortisol, norepinephrine, kana kuti prolactin? Tichifunga nezvemubvunzo wapfuura, nyora mashoko akapoteredza mhinduro yacho. Inogona kuva mitsara 1 - 20. Mashoko akapoteredza:  <response>: Mukuwedzera kumigumisiro yakaipa yokushayikwa kwehope, kurara nehurongwa hwemazuva ose hwakapindirana zvakaratidzwa kuva nemigumisiro yakasimba yokudzora pamabasa ezvirwere zvokurwisa zvirwere zvinopesvedzera zvose zviri zviviri kudzivirirwa kwomuzvarirwo nokugadziriswa. Chokutanga, panguva yokutanga yokurara kwenguva refu, kuderera kamwe kamwe kwe cortisol, epinephrine, uye norepinephrine muropa kunowedzera uwandu hwemahomoni anonzi leptin, pituitary growth hormone, uye prolactin. Zviratidzo izvi zvinokonzera mamiriro anokonzera kuzvimba kuburikidza nokugadzirwa kwepro- inflammatory cytokines interleukin-1, interleukin-12, TNF- alpha uye IFN- gamma. Aya ma cytokine anobva anokurudzira mashandiro ezvirwere zvomuviri zvakadai sokushanda kwemasero ezvirwere zvomuviri, kuwanda, uye kusiyanisa. Munguva iyi ndipo panosvika undifferentiated, kana kuti undifferentiated zvishoma, zvakadai seT cells dzisina kusimba uye dzokuyeuka dzinokosha, kureva munguva yokushanduka-shanduka zvishoma nezvishoma kworudzi rwomuviri rwomuviri rwomuviri. Mukuwedzera kumigumisiro iyi, mahormone anogadzirwa panguva iyi leptin, pituitary growth hormone, uye prolactin anotsigira kudyidzana pakati peAPCs neT- masero, kuchinja kweTh1Th2 cytokine balance kune imwe inotsigira Th1, kuwedzera kwehuwandu hwese hwekupararira kwemasero eT, uye kutama kwemasero eT asina kumboita basa kuenda kumakemikari. Iyi nharaunda inofungidzirwawo kutsigira kuumbwa kwechiyeuchidzo chemaviri chinogara kwenguva refu kuburikidza nokutanga kwemhinduro dzemaviri dzeTh1. 