<prompt> Pedzisa mutsara unotevera: Achishanda paRockefeller Institute for Medical Research pakati pa1915 na1919, Israel Kleiner akataura nezvezvakabuda pakutsvakurudza kwaakaita nezvemigumisiro yepancreatic ground solution pamwero weshuga muropa, achishandisa ongororo dzakasimba dzokuedza dzapfungwa... dzaitsigira pfungwa yokuti shuga inokonzerwa nokubuda kwemvura mumuviri uye pazviri kuitwa... zvairatidza kuti inogona kushandiswa pakurapa. Akarega basa iri paakasiya Rockefeller institute muna 1919, nokuda kwezvikonzero zvisinganyatsozivikanwi. Mumwe musayendisiti wokuRomania Nicolae Paulescu, mumwe munhu anozivikanwa mukutsvaka chinorwisa chirwere cheshuga, akatanga kuedza muna 1916 achishandisa mushonga unonyungudutsa mudumbu une munyu muduku wakaita sowaKleiner. Pashure pokuvhiringidzwa ne  <response>: Muhondo yeBucharest uye mhirizhonga yapashure pehondo, akabudisa migumisiro yake yokutanga muchiFrench muna 1920 na1921. Zvinhu zvaaiwana zvaiita kuti shuga iri muropa neiri mumuromo zviderere zvakajeka kumbwa dzaiongororwa, asi zvaisaita kuti varwere vake vave nemigumisiro pakarepo pavainge vabaiwa majekiseni mumuromo yaisagona kudzokororwa nemushonga wemunyu chete. Paulescu akatora patent yeRomania pamhinduro yake iyo yaakadana kuti pancréine uye nzira yekugadzira, asi mukati megore rinotevera, haana kufambira mberi nebasa rake nekuda kwekushaikwa kwemari. 