<prompt> Mushure mekunge chirwere ichi chaenderera mberi, kusagadzikana kwechirwere chechirwere kunopindirana zvakanyanya nekuvandudzwa kwezvinhu zvisiri izvo zvemidziyo yeropa, zvakadai se capillary basement membrane thickening uye endothelial hyperplasia, iyo inobatsira kuderedza kukanganiswa kweoksijeni uye hypoxia. Neuronal ischemia chinhu chakanyatsogadziriswa chechirwere cheshuga cheshuga. Zvirwere zvemuviri semuenzaniso, ACE inhibitors, α1-antagonists zvinogona kutungamira mukuvandudzwa kwakanyanya mukuyerera kweropa kwechirwere cheshuga, pamwe nekuvandudzwa kunoenderana nekumhanyisa kweropa. Saka, kusagadzikana kwemidziyo yeropa kunoitika pakutanga, mukufambira mberi kwechirwere cheshuga, pamwe nekutsigirwa kwekushomeka kwemidziyo yeropa, uye shanduko dzakakwana dzekuyerera kweropa dzinogona kucherechedzwa. Mubvunzo: Chii chinoitwa nemishonga yekurapa?  <response>: kutungamirira kukuvandudzwa kukuru 