<prompt> Rangarira ndima iri pasi apa uye ipapo pindura mubvunzo gare gare mumutauro mumwe chetewo sechikamu: Kupfuura: Acetylsalicylic acid iasidhi isina simba, uye shoma kwazvo ndiyo inoiswa ionized mudumbu pashure pokupinza nomuromo. Acetylsalicylic acid inokurumidza kunyura nomumadziro etsinga mumamiriro ezvinhu eacid emudumbu. Kuwedzera kwepH uye nzvimbo yakakura yomudumbu duku kunoita kuti aspirin ipinde zvishoma nezvishoma imomo, sezvo yakawanda yayo ichipiswa. Nemhaka yokuumbwa kweconcretions, aspirin inonyudzwa zvishoma nezvishoma panguva yokunyanyisa, uye plasma concentrations inogona kuramba ichikwira kwemaawa anosvika 24 pashure pokunwa. Inenge 5080 yesalicylate muropa inosungirirwa kupuroteni yealbumin, nepo zvimwe zvose zvichiramba zviri mumamiriro ezvinhu anoshanda, ionized; protein inosunga inotsamira pakusungwa. Kugutsikana kwenzvimbo dzinosunga kunotungamirira kune salicylate yakasununguka uye kuwedzerwa kwehupfu. Kuwanda kwekuparadzirwa kwacho kuri 0. 1 kusvika ku 0. 2 L kg. Acidosis inowedzera huwandu hwekuparadzirwa nekuda kwekuwedzera kwekupinda kwehutano hwe salicylates. Zvakawanda se80 yemishonga yekurapa salicylic acid inogadziriswa muchiropa. Kubatanidzwa neglycine kunogadzira salicyluric acid, uye ne glucuronic acid kuumba maviri akasiyana glucuronide esters. Iyo conjugate ine boka reacetyl risina kukanganiswa inonzi acyl glucuronide; iyo deacetylated conjugate ndiyo phenolic glucuronide. Nzira idzi dzokuchinja zvinhu mumuviri dzine simba shoma chete. Zvishoma zve salicylic acid zvinonziwo hydroxylated kuva gentisic acid. Nemishonga mikuru yesalicylate, kinetics inoshanduka kubva ku-first-order kuenda ku-zero-order, sezvo nzira dzomuviri dzinova dzakazara uye kubuda kweitsvo kunova kunokosha zvikuru. Salicylates inobudiswa zvikurukuru neitsvo se salicyluric acid 75, salicylic acid yakasununguka 10, salicylic phenol 10, uye acyl glucuronides 5, gentisic acid 1, uye 2,3-dihydroxybenzoic acid. Apo madosi maduku asingasviki 250 mg mumunhu mukuru anodyiwa, nzira dzose dzinofambira mberi nefirst- order kinetics, ine elimination half- life yeanenge maawa 2. 0 kusvika kumaawa 4. 5. Apo madosi akakwirira esalicylate anodyiwa anopfuura 4 g, hafu yenguva inova yakareba zvikuru maawa 15 kusvika ku30... Mubvunzo: Kugoverwa kweaspirin nomuvhoriyamu kwakadini?  <response>: 0.10.2 Lkg 