<prompt> Rangarira ndima iri pasi apa uye ipapo pindura mubvunzo gare gare mumutauro mumwe chetewo sechikamu: Passage: Muzana ramakore rechi 19 nerechi 20, mushonga wemishonga usati wabudirira kurapa BP, nzira nhatu dzokurapa dzaishandiswa, dzose dziine migumisiro yakaipa yakawanda: kuderedza sodium somuenzaniso kudya mupunga, sympathectomy kuvhiya kubvisa zvikamu zve sympathetic nervous system, uye pyrogen therapy kubaya majekiseni ezvinhu zvinokonzera fivha, zvisina kunanga kuderedza BP. Chemical yekutanga yeBP, sodium thiocyanate, yakashandiswa muna 1900 asi yakanga ine migumisiro yakaipa yakawanda uye yakanga isingafarirwi. Dzimwe mishonga yakati wandei yakagadzirwa pashure peHondo Yenyika II, yakakurumbira zvikuru uye yaibudirira zvikuru yaive tetramethylammonium chloride, hexamethonium, hydralazine, uye reserpine yakatorwa mumuti unorapa Rauwolfia serpentina. Hapana chimwe cheizvi chakanyatsobvumirwa. Kufambira mberi kukuru kwakaitwa nokuwanwa kwezvinhu zvokutanga zvinobvumirwa zvakanaka zvinoshandiswa nomuromo. Yokutanga yaiva chlorothiazide, diuretic yokutanga ye thiazide uye yakagadzirwa kubva pamushonga unorwisa mabhakitiriya sulfanilamide, uyo wakawanikwa muna 1958. Gare gare, ma beta blocker, calcium channel blockers, angiotensin converting enzyme ACE inhibitors, angiotensin receptor blockers, uye renin inhibitors zvakagadziridzwa semishonga inorwisa hypertension. Mubvunzo: Chii chinonzi mushonga unobva muchirimwa chinonzi Rauwolfia?  <response>: gadziriro 