<prompt> Gadzira shanduro yakaoma kunzwisisa yeiyi mutsara Iyo yepasi gastrointestinal tract inoshaya doro dehydrogenase enzyme iripo mudumbu uye chiropa iyo inoputsa ethanol muacetylaledhyde.  <response>: Ichokwadi, shanduro yakaoma kunzwisisa yemutsara uyu ndeiyi The lower gastrointestinal tract lacks the alcohol dehydrogenase enzyme present in the stomach and liver that breaks down ethanol into acetylaldehyde, which is actually more toxic than ethanol drinking alcohol and is responsible for most chronic effects of ethanol. 