<prompt> Kupfuurira kweiyi ndima - Achishanda paRockefeller Institute for Medical Research pakati pa1915 na1919, Israel Kleiner akashuma migumisiro inonyengetedza pamigumisiro yemhinduro dzepancreas dzakagadziriswa pamwero wehuga yeropa, achishandisa kudzora kwakasimba kwekuedza uko mune dzidziso... kunotsigira ed fungidziro yemukati yekubudiswa kwechirwere cheshuga uye mukuita... yakaratidza kushandiswa kunorapa kunobvira. Akarega basa iri paakasiya Rockefeller institute muna 1919, nokuda kwezvikonzero zvisinganyatsozivikanwi. Mumwe musayendisiti wokuRomania Nicolae Paulescu, mumwe munhu anozivikanwa mukutsvaka chinorwisa chirwere cheshuga, akatanga kuedza muna 1916 achishandisa mushonga unonyungudutsa mudumbu une munyu muduku wakaita sowaKleiner. Pashure pokuvhiringidzwa neHondo yeBucharest  <response>: uye nyonganyonga yapashure pehondo, akabudisa migumisiro yake yokutanga muchiFrench muna 1920 na1921. Zvinhu zvaaiwana zvaiita kuti shuga iri muropa neiri mumuromo zviderere zvakajeka kumbwa dzaiongororwa, asi zvaisaita kuti varwere vake vave nemigumisiro pakarepo pavainge vabaiwa majekiseni mumuromo yaisagona kudzokororwa nemushonga wemunyu chete. Paulescu akatora patent yeRomania pamhinduro yake iyo yaakadana kuti pancréine uye nzira yekugadzira, asi mukati megore rinotevera, haana kufambira mberi nebasa rake nekuda kwekushaikwa kwemari. 