<prompt> Rangarira ndima iri pasi apa uye ipapo pindura mubvunzo gare gare mumutauro mumwe chetewo sechikamu: Kupfuura: Aspirin yakaratidzirwa kuva nedzimwe nzira nhatu dzokuita nadzo. Inobvisa oxidative phosphorylation mu cartilaginous uye hepatic mitochondria, nekuparadzira kubva mukati memukati memukati semutakuri weproton kudzokera mu mitochondrial matrix, uko ino ionizes zvakare kusunungura protons. Aspirin inochengetedza uye inotakura mapurotoni. Apo madosi makuru anopiwa, anogona chaizvoizvo kukonzera fivha, nemhaka yokupisa kunobudiswa kubva muketani yokutakura maerekitironi, mukusiyana nemubato weantipyretic weaspirin unoonwa nemadosi akaderera. Mukuwedzera, aspirin inokurudzira kugadzirwa kweNO- radicals mumuviri, iyo yakaratidzirwa mumakonzo kuva negadziriro yakazvimirira yokuderedza kuzvimba. Uku kuderedzwa kwokubatanidzwa kwe leukocyte inhanho inokosha mukupindura kwokurwisa utachiona; zvisinei, uchapupu hahuna kukwana kuratidza kuti aspirin inobatsira kurwisa utachiona. Mashoko azvino uno anoratidzawo kuti salicylic acid nemamwe makemikari ayo anochinja mashandiro anoita NF-κB. NF-κB, inonzi transcription factor complex, inoita basa rinokosha pamabasa akawanda omuviri, kusanganisira kuzvimba. Mubvunzo: NF-kB chii?  <response>: chinonzi transcription factor complex 