<prompt> Gadzira shanduro yakaoma zvikuru yemutsara uyu Cold - patches dzave dzichishandiswa nenzira yechinyakare kukonzera analgesia kana kubvisa marwadzo anokonzerwa nokukuvara kunokuvadza.  <response>: Chokwadika, shanduro yakaoma kunzwisisa zvikuru yemutsara wacho ndeiyi Cold - patches have been used to induce analgesia or relief in pain as a result of traumatic injuries ; its mechanism remained obscure until the discovery of TRPM8 mediated cold analgesia in rats and mice lacking TRPM8 have seriously impaired cold - detection behavior. 