<prompt> Bheka isigaba esingezansi bese uphendula umbuzo emva kwalokho ngolimi olufanayo nesigaba: Ukudlula: Kuye kwaboniswa ukuthi i-aspirin inezinye izindlela ezintathu zokwenza okuthile. Ihlukanisa i-oxidative phosphorylation kuma-mitochondria e-cartilaginous ne-hepatic, ngokuhlakazeka kusuka esikhaleni sangaphakathi se-membrane njengomthwali we-proton emuva ku-mitochondrial matrix, lapho i-ionizes khona futhi ukukhulula ama-proton. I-Aspirin ivikela futhi ithuthe ama-proton. Lapho kunikezwa imithamo ephezulu, empeleni ingase ibangele imfiva, ngenxa yokushisa okuphuma eketangeni lokuthutha ama-electron, ngokungafani nesenzo se-antipyretic se-aspirin esibonwe ngemithamo ephansi. Ngaphezu kwalokho, i-aspirin ibangela ukwakheka kwama-NO- radicals emzimbeni, okuye kwaboniswa kumagundane ukuthi anendlela ezimele yokunciphisa ukuvuvukala. Lokhu kuncishiswa kokunamathela kwama-leukocyte kuyisinyathelo esibalulekile ekuphenduleni kwamasosha omzimba ekungenweni izifo; kodwa-ke, ubufakazi abenele bokubonisa ukuthi i-aspirin iyasiza ekulweni nokutheleleka. Imininingwane yakamuva iphinde isikisele ukuthi i-salicylic acid kanye nemikhiqizo yayo kuyalungisa ukubonisa nge-NF-κB. I- NF-κB, eyinkimbinkimbi ye-transcription factor, idlala indima ebalulekile ezinkambisweni eziningi zezinto eziphilayo, kuhlanganise nokuvuvukala. Umbuzo: Iyini i-NF-kB?  <response>: inhlanganisela ye-transcription factor 