<prompt> Yakha inguqulo eyinkimbinkimbi yalesi sigwebo Ama-patch abandayo ngokwesiko asetshenziselwa ukubangela ukucindezelwa noma ukukhululeka ebuhlungwini obubangelwa ukulimala okubuhlungu.  <response>: Yiqiniso, inguqulo eyinkimbinkimbi yalesi sigwebo ithi Ama - patch abandayo aye asetshenziselwa ukubangela ukuzwa ubuhlungu noma ukudambisa ubuhlungu ngenxa yokulimala okubuhlungu; inqubo yawo yahlala ingaziwa kwaze kwaba yilapho kutholakala ukuthi i - TRPM8 ilawula ukuzwa ubuhlungu obandayo kumagundane namagundane angenayo i - TRPM8 futhi ayithikameza kakhulu indlela yokuzwa ukubanda. 