<prompt> Bheka isigaba esingezansi bese uphendula umbuzo emva kwalokho ngolimi olufanayo nesigaba: Ukudlula: Izifo zemithambo yegazi nezemizwa zihlobene kakhulu futhi zixhumene. Imithambo yegazi ixhomeke ekusebenzeni okuvamile kwezinzwa, futhi izinzwa zixhomeke ekugelezeni kwegazi okwanele. Ushintsho lokuqala lwezifo emithanjeni emincane yegazi ukuncibilika kwemithambo yegazi. Njengoba lesi sifo siqhubeka, ukungasebenzi kahle kwe-neuronal kuhlobene kakhulu nokuthuthukiswa kokungajwayelekile kwemithambo yegazi, njengokuqina kwe-capillary basement membrane kanye ne-endothelial hyperplasia, okufaka isandla ekunciphiseni ukucindezela komoya-mpilo kanye ne-hypoxia. I-neuronal ischemia iyisici esiqinisekisiwe se-neuropathy yesifo sikashukela. Izidakamizwa ezivula imithambo yegazi isib., ama-ACE inhibitors, ama-α1-antagonists zingaholela ekuthuthukisweni okukhulu kokugeleza kwegazi kwe-neuronal, ngokuthuthuka okuhambisanayo kwejubane lokuhambisa izinzwa. Ngakho-ke, ukungasebenzi kahle kwemithambo yegazi encane kwenzeka ekuqaleni kwesifo sikashukela, kuhambisana nokuqhubeka kokungasebenzi kahle kwezinzwa, futhi kunganele ukusekela ubukhulu bezinguquko zesakhiwo, zokusebenza, nezomtholampilo ezibonwe ku-neuropathy yesifo sikashukela. Umbuzo: Yini eyenziwa izidakamizwa ezandisa imithambo yegazi ekugelezeni kwegazi lezinzwa?  <response>: ukuholela ekuthuthukisweni okukhulu 