<prompt> Bhala okuqhubekayo kwalesi sigaba - UCharles, owabekwa esihlalweni sobukhosi njengenkosi eJalimane, waba sohlangothini lukaPapa uLeo X futhi wamemezela uMartin Luther njengongekho emthethweni eMhlanganweni WaseWorms 1521. Ngawo lowo nyaka, uFrancis I waseFrance, owayezungezwe izimpahla zamaHabsburg, waqala impi eLombardy eyaqhubeka kwaze kwaba iMpi YasePavia 1525, eyaholela ekuboshweni kwesikhashana kwenkosi yaseFrance. Inkinga yamaProthestani yaphinde yavela ngo-1527 lapho iRoma igqekezwa ibutho lamasosha kaCharles avukelayo, iningi lawo elalingamaLuthela. Ngemva kokuba amabutho akhe eshiye iZwe LikaPapa, uCharles V wavikela iVienna  <response>: kumaTurkey futhi wathola ukubekwa esihlalweni sobukhosi njengeNkosi e-Italy uPapa Clement VII. Ngo-1535, wahlanganisa iDukey yaseMilan eyayingasenabantu futhi wathatha iTunis. Noma kunjalo, ukulahleka kweBuda ngesikhathi sokulwa neHungary kanye ne-Algiers Expedition ekuqaleni kwawo-1540 kwaphazamisa izinqubomgomo zakhe zokulwa nama-Ottoman. Phakathi naleso sikhathi, uCharles V wayevumelene noPapa Paul III ngokuhlelwa koMkhandlu WaseTrent 1545. Ukwenqaba kweLutheran Schmalkaldic League ukuqaphela ukuba semthethweni kwalo mkhandlu kwaholela empini, eyatholwa uCharles V ngokuboshwa kwezikhulu ezingamaProthestani. Nokho, uHenry II waseFrance waqhubeka esekela amaLuthela futhi waqinisa ubuhlobo obuseduze neSultan Suleiman the Magnificent, umbusi woMbuso Wase-Ottoman kusukela ngo-1520. 