<prompt> Bhala okuqhubekayo kwalesi sigaba - Esebenza eRockefeller Institute for Medical Research phakathi kuka - 1915 no - 1919, u - Israel Kleiner wabika ngemiphumela ekholisayo ngomphumela wesisombululo sepancreas esigaywe emazingeni kashukela egazini, esebenzisa izivivinyo eziqinile zokuhlola ngokombono... ezisekela umbono wokukhishwa kwangaphakathi kwemvelaphi yesifo sikashukela futhi ngokusebenza... ezibonisa ukusetshenziswa okungenzeka kwezokwelapha. Wawuyeka lo msebenzi lapho eshiya iRockefeller institute ngo - 1919, ngenxa yezizathu ezingaziwa ngokucacile. Usosayensi waseRomania uNicolae Paulescu, omunye umuntu ovelele ekufuneni into elwa nesifo sikashukela, waqala ukuhlola ngo-1916 esebenzisa isixazululo se-pancreatic esinosawoti omncane njengoKleiner. Ngemva kokuphazamiseka yiMpi YaseBucharest  <response>: nezinkathazo zangemva kwempi, washicilela imiphumela yakhe yokuqala ngesiFulentshi ngo-1920 nango-1921. Izithasiselo zakhe zaholela ekunciphiseni okucacile kwegazi noshukela womchamo ezinjeni ezihloliwe, kodwa zazingenawo umphumela osheshayo ezigulini zakhe ezingabantu ngomjovo we-rectal owawungeke uphindwe ngemithamo yomjovo womzimba kuphela. UPaulescu wathola ilungelo lobunikazi laseRomania ngesixazululo sakhe asibiza ngokuthi pancréine nendlela yokukhiqiza, kodwa ngonyaka olandelayo, akazange athuthuke emsebenzini wakhe ngenxa yokuntuleka kwemali. 