<prompt> Fingqa isihloko: Ucwaningo olukhulu luye lwaxwayisa ngokuthi i-paracetamol ethathwa nsuku zonke ingandisa ingozi yokuhlaselwa yisifo senhliziyo, unhlangothi nokufa ngaphambi kwesikhathi. Ucwaningo olukhulu namuhla luyexwayisa ngokuthi i-paracetamol yansuku zonke ingandisa ingozi yokuhlaselwa yisifo senhliziyo, unhlangothi nokufa ngaphambi kwesikhathi. Lwathola ukuthi iziguli ezazinikezwa imithamo ephezulu yomuthi wokuqeda izinhlungu isikhathi eside zazinamathuba angamaphesenti angu-63 okufa kungalindelekile. Ingozi yokuba nesifo senhliziyo noma unhlangothi yayiphakeme ngamaphesenti angu-68 futhi kwakunamathuba aphakeme ngamaphesenti angu-50 okuba nesilonda esiswini noma ukopha. Odokotela bathi i - paracetamol iphephile kune - aspirin, engabangela ukopha esiswini, ne - ibuprofen, okuye kwahlotshaniswa nokuhlaselwa yisifo senhliziyo nokushaywa unhlangothi. Kodwa abacwaningi baseBrithani ababheka izifundo ezihilela iziguli ezingu-666 000 bathi kungenzeka izingozi ziye zancishiswa futhi bacela ukuba kwenziwe ukubuyekezwa okukhulu kokuphepha kwalesi sidakamizwa. Bacabanga ukuthi i-paracetamol ingase ibangele ukugula ngokuvimbela isenzo se-enzyme emzimbeni ebizwa ngokuthi i-COX-2. Ososayensi abavela eLeeds Institute of Rheumatic and Musculoskeletal Medicine babukeza izifundo eziyisishiyagalombili ezaziqukethe ukwaziswa ngeziguli ezazithatha i-paracetamol nsuku zonke iminyaka engaba ngu-14, ngenxa yezimo ezinjengesifo samathambo nobuhlungu obukhulu bomhlane. Futhi zazihlanganisa iziguli ezazithatha umuthi kancane noma zingawuthathi nhlobo. UPhilip Conaghan, owayehola kulolu cwaningo, waveza ukuthi ezigulini eziningi izingozi zazimncane kakhulu futhi lezo ezanikezwa i-paracetamol isikhathi eside zaziyoba nezifo ezingase zizibulale ngokushesha. Ngenxa yalesi sizathu kwakunzima ukuqiniseka ukuthi imithi yayibangela izinkinga. Kodwa uprofesa wanezela: Ngikhathazekile kancane ngokuthi uma i-paracetamol isetshenziswa ngamanani aphezulu isikhathi eside ingase ibe nemiphumela engemihle ebesingakaze siyihlanganise ngaphambili. Uthe iziguli ezinikezwa imithi isikhathi eside ngenxa yesifo sokuqaqamba kwamalunga noma ubuhlungu bemisipha namalunga kufanele zikhulume nodokotela wazo ngezinye izindlela zokwelapha, njengokuvivinya umzimba. Lolu cwaningo, olwanyatheliswa ephephabhukwini i - Annals of the Rheumatic Diseases, lwaphetha ngokuthi: Ngenxa yokusetshenziswa kwalo kabanzi nokutholakala kwalo, indlela ehlelekile...  <response>: Labo abasebenzisa izidakamizwa isikhathi eside baba namathuba aphakeme okuthi bafe ngokuzumayo ngamaphesenti angu - 63. Ucwaningo luye lwaxwayisa ngokuthi ingozi yabo yokuhlaselwa yisifo senhliziyo noma isifo sohlangothi nayo iphakeme ngo-68. Abacwaningi baseBrithani abasekela lolu cwaningo manje bacela ukuba kubuyekezwe izidakamizwa. Bathi umuthi ungaba yimbangela yokugula ngokuvimbela i-enzyme ebizwa nge-COX-2. 