<prompt> Bhala okuqhubekayo kwalesi sigaba - Ukuqubuka kwe-Soho eLondon ngo-1854  <response>: kwaphela ngemva kokuba udokotela uJohn Snow ethole ukuthi ipompo lasendaweni yaseBroad Street lingcolisiwe futhi waqinisekisa izikhulu ukuba zisuse isibambo salo. USnow wayekholelwa ukuthi amanzi angcoliswe amagciwane ayewumthombo wekholera, hhayi izinhlayiya ezisemkhathini ezaziwa ngokuthi i-miasmata. Ucwaningo lwakhe lwafakazela ukuthi amanzi angcolile ayeyiyona nto eyinhloko eyayisakaza ikholera, nakuba engazange ayichaze into engcolisayo. Nakuba uFilippo Pacini ayehlukanise i-Vibrio cholerae njengento ebangela ikholera ngalowonyaka, kwakuyodlula iminyaka eminingi ngaphambi kokuba inkolelo-mbono ye-miasma iphelelwe umusa. 