<prompt> Bhala okuqhubekayo kwalesi sigaba - Ngekhulu le-19, iBrithani yayiyisikhungo sokwanda okusheshayo kwamadolobha, futhi ngenxa yalokho, izinkinga eziningi zezempilo nezokuhlanzeka zabonakala, ngokwesibonelo ukuqubuka kwekholera kanye nezifo eziwumshayabhuqe. Lokhu kwaphumela ekubeni iBrithani idlale indima enkulu ekuthuthukiseni impilo yomphakathi. Ngaphambi kokuba kutholakale ukuhlobana phakathi kwamanzi okuphuza angcolile nezifo, njengekholera nezinye izifo ezithathelwana ngamanzi, kwakusetshenziswa inkolelo-mbono ye-miasma ukuze kuqinisekiswe ukuqubuka kwalezi zifo. Umbono we - miasma uwumbono wokuthi izifo ezithile ziwumkhiqizo womoya omubi. Ucwaningo lukadokotela uJohn Snow e-United Kingdom ngesikhathi kuqubuka ikholera ngo-1854 eBroad Street  <response>: kwacacisa ukuxhumana phakathi kwezifo ezithathelwana ngamanzi namanzi okuphuza angcolile. Nakuba inkolelo-mbono ye-germ yezifo yayingakasungulwa, ukuhlola kukaSnow kwamholela ekubeni alahle inkolelo-mbono evamile ye-miasma. Indatshana yakhe yango-1855 ethi On the Mode of Communication of Cholera yabonisa ngokucacile indima yokunikezwa kwamanzi ekusakazeni ubhubhane lwekholera eSoho, kusetshenziswa imephu yokusabalalisa amachashazi nobufakazi obungokwezibalo ukukhombisa ukuxhumana phakathi kwekhwalithi yomthombo wamanzi namacala ekholera. Phakathi nobhadane lwango - 1854, waqoqa futhi wahlaziya imininingwane eyabonisa ukuthi abantu abaphuza amanzi emithonjeni engcolisiwe njengompompi waseBroad Street babebulawa ikholera ngamanani aphakeme kakhulu kunalabo abaphuza amanzi kwenye indawo. Imininingwane yakhe yakholisa umkhandlu wendawo ukuba ukhubaze iphampu yamanzi, okwaqeda ngokushesha ukuqubuka kwalesi sifo. 