<prompt> Bheka isigaba esingezansi bese uphendula umbuzo emva kwalokho ngolimi olufanayo nesigaba: Ukudlula: I-acetylsalicylic acid iyi-acid ebuthakathaka, futhi incane kakhulu i-ionized esiswini ngemva kokuphathwa ngomlomo. I-acetylsalicylic acid imuncwa ngokushesha ulwelwesi lwamangqamuzana ezimweni zesiswini ezinomsoco. Ukwanda kwe-pH nendawo enkulu yesibeletho esincane kubangela ukuba i-aspirin imuncwe kancane lapho, njengoba iningi layo liyi-ionized. Ngenxa yokwakheka kwama-concretion, i-aspirin imuncwa kancane kakhulu ngesikhathi sokusebenzisa ngokweqile, futhi amazinga e-plasma angaqhubeka nokukhuphuka kuze kube amahora angama-24 ngemuva kokudla. Cishe ama-50 -80 e-salicylate esegazini aboshelwe ku-albumin protein, kanti okusele kuhlala kusesimweni esisebenzayo, se-ionized; ukubopha kwamaprotheni kuncike ekugxileni. Ukugcwala kwezindawo zokubopha kuholela ku-salicylate ekhululekile kanye nobuthi obandayo. Umthamo wokusatshalaliswa ngu- 0. 1 0. 2 L kg. I-acidosis yandisa ivolumu yokusabalalisa ngenxa yokwanda kokungena kwezicubu zama-salicylates. Ukuhlanganiswa ne - glycine kwakha i - salicyluric acid, ne - glucuronic acid kwakha ama - ester amabili ahlukene e - glucuronide. I-conjugate eneqembu le-acetyl elilungile ibizwa ngokuthi i-acyl glucuronide; i-conjugate e-deacetylated yi-phenolic glucuronide. Lezi zindlela zokugaya ukudla zinomthamo olinganiselwe kuphela. Amanani amancane e-salicylic acid nawo ahlanganiswa ne-hydroxylated ku-gentisic acid. Uma kunemithamo emikhulu ye-salicylate, i-kinetics ishintsha isuka ku-first-order iye ku-zero-order, njengoba izindlela ze-metabolic zigcwala futhi ukukhishwa kwezinso kuba okubaluleke ngokwengeziwe. Ama-salicylates akhishwa ikakhulukazi izinso njenge-salicyluric acid 75, i-salicylic acid yamahhala 10, i-salicylic phenol 10, kanye ne-acyl glucuronides 5, i-gentisic acid 1, ne- 2,3-dihydroxybenzoic acid. Lapho kuthathwa imithamo emincane ngaphansi kuka-250 mg kumuntu omdala, zonke izindlela ziqhubeka nge-kinetics ye-first-order, nge-half-life yokukhipha cishe amahora angu-2.0 kuya ku-4.5. Lapho kuthathwa imithamo emikhulu ye-salicylate ngaphezu kuka- 4 g, isikhathi sokuphindeka kabili siba side kakhulu amahora angu- 15 kuya kwangu- 30. Umbuzo: Iyini ivolumu yokwabiwa kwe-aspirin?  <response>: 0.10.2 Lkg 