<prompt> Fingqa isihloko: Ososayensi bathi basondele kakhulu ekwakheni umuthi ongelapha i - HIV. Iqembu labacwaningi belilokhu lenza ngokwezifiso isimiso sokuzivikela esisetshenziswa amagciwane futhi liqeqesha lo mshini ofana nesikele ukuba ubone igciwane le-HIV. Ekuhlolweni kwabo, bathola ukuthi le ndlela ingasusa ngokuphelele amangqamuzana angamaphesenti angu-72 ayene-HIV. Iqembu labacwaningi belilokhu lenza ngokwezifiso isimiso sokuzivikela esisetshenziswa amagciwane futhi liqeqesha lo mshini ofana nesikele ukuba ubone igciwane le-HIV esithombeni ubuchwepheshe be-CRISPR buguqula ngokunembile izingxenye ezihlosiwe zekhodi yofuzo. Ngokungafani namanye amathuluzi acisha izakhi zofuzo, uhlelo lweCrispr lubhekisa ezintweni ezakha i-genome bese luvala izakhi zofuzo unomphela ezingeni le-DNA. Ukwehlukaniswa kwe - DNA okwaziwa ngokuthi i - double strand break kulingisa ngokuseduze izinhlobo zokuguquka kwezakhi zofuzo ezenzeka ngokwemvelo, ngokwesibonelo ngemva kokuchayeka isikhathi eside elangeni. Kodwa ngokungafani nemisebe ye-UV engabangela ushintsho oluthile zofuzo, uhlelo lweCrispr lubangela ushintsho endaweni ethile ethile ku-genome. Lapho imishini yamangqamuzana ilungisa ukuphuka kwe - DNA, isusa ucezu oluncane lwe - DNA. Ngale ndlela, abacwaningi bangakwazi ukuvala izakhi ezithile zofuzo ngokuqondile. Ukuziphendukela kwemvelo kuye kwaholela kwezinye zezindlela ezimangalisa kakhulu zokuvikela izidalwa eziphilayo emagciwaneni azo angokwemvelo, kusho uJuan Carlos Izpisua Belmonte, uprofesa eSalks Gene Expression Laboratory eCalifornia. Ukuqonda ukusabela kwamasosha omzimba amagciwane azivikela ngawo ekungenweni amagciwane kuye kwasenza sakwazi ukuklama izindlela ezintsha zokuhlasela amagciwane ayingozi, njenge-HIV, ezigulini ezingabantu. Lapho ikhophi yegciwane lesandulela - ngculaza ingena ngokucashile engqamuzaneni lomuntu, ingadala umonakalo. Ilawula imishini yamangqamuzana eseceleni ngokwayo ukuze yenze amakhophi ezakhi zofuzo zegciwane bese ingcwaba la makhophi egazini lengqamuzana ngokwalo. Ukusuka lapho, ingqamuzana lomzimba liba ifektri ye-HIV, ikhiqiza amakhophi amasha egciwane ukuze lisakazeke emzimbeni wonke. Imithi ekhona ye-HIV igxila ezigabeni ezithile zalomjikelezo wokuphila; eminye ivimbela igciwane ukuba lingene...  <response>: Ososayensi baqeqeshe amabhaktheriya anjengomshini wokusika ukuze abone igciwane i - HIV. Bathola indlela yokusika ngempumelelo izakhi zofuzo ze-HIV, okwenza igciwane lingasebenzi. Lokhu kwaholela ekutheni igciwane lisuswe kumaseli afinyelela kumaphesenti angu-72. Le ndlela ye - CRISPR yabuye yahlukanisa i - HIV eyayingabonakali ngaphakathi kwe - DNA yamangqamuzana. Ucwaningo lwakamuva lubonisa ukuthi le ndlela iyasebenza ekulweni ne-HIV esebenzayo, ephelele kunenguqulo efushanisiwe, engasebenzi yegciwane. 