<prompt> Bhala okuqhubekayo kwalesi sigaba - Ngekhulu le-19, iBrithani yayiyisikhungo sokwanda okusheshayo kwamadolobha, futhi ngenxa yalokho, izinkinga eziningi zezempilo nezokuhlanzeka zabonakala, ngokwesibonelo ukuqubuka kwekholera kanye nezifo eziwumshayabhuqe. Lokhu kwaphumela ekubeni iBrithani idlale indima enkulu ekuthuthukiseni impilo yomphakathi. Ngaphambi kokuba kutholakale ukuhlobana phakathi kwamanzi okuphuza angcolile nezifo, njengekholera nezinye izifo ezithathelwana ngamanzi, kwakusetshenziswa inkolelo-mbono ye-miasma ukuze kuqinisekiswe ukuqubuka kwalezi zifo. Umbono we - miasma uwumbono wokuthi izifo ezithile ziwumkhiqizo womoya omubi. Ukuhlola kukadokotela uJohn Snow e-United Kingdom ngesikhathi kuqubuka isifo sekholera ngo-1854 eBroad Street kwacacisa ukuhlobana phakathi kwezifo ezithathelwana ngamanzi namanzi okuphuza angcolile. Nakuba inkolelo-mbono yokuthi izifo zibangelwa amagciwane yayingakasungulwa, lokho ayekubonile kwamenza wenqaba inkolelo-mbono evamile yokuthi izifo zibangelwa ama-miasma. Indatshana yakhe yango-1855 ethi On the Mode of Communication of Cholera yabonisa ngokucacile indima yokunikezwa kwamanzi ekusakazeni ubhubhane lwekholera eSoho, kusetshenziswa imephu yokusabalalisa amachashazi nobufakazi obungokwezibalo ukukhombisa ukuxhumana phakathi kwekhwalithi yomthombo wamanzi namacala ekholera. Phakathi nobhadane lwango-1854, waqoqa futhi wahlaziya imininingwane eqinisekisa ukuthi abantu abaphuza amanzi emithonjeni engcolisiwe njengompompi waseBroad Street  <response>: babulawa ikholera ngamanani aphakeme kakhulu kunalabo abathola amanzi kwenye indawo. Imininingwane yakhe yakholisa umkhandlu wendawo ukuba ukhubaze iphampu yamanzi, okwaqeda ngokushesha ukuqubuka kwalesi sifo. 