<prompt> Isigaba: Izifo zemithambo yegazi nezifo zemithambo yegazi zihlobene kakhulu futhi zihlangene. Imithambo yegazi incike ekusebenzeni okujwayelekile kwemithambo yegazi, futhi imithambo yegazi incike ekugelezeni kwegazi okwanele. Ushintsho lokuqala lwe-pathological emithanjeni emincane yegazi ukuncipha kwemithambo yegazi. Njengoba isifo siqhubeka, ukungasebenzi kahle kwemithambo yegazi kuhlobene kakhulu nokuthuthukiswa kokungajwayelekile kwemithambo yegazi, njengokuqina kwe-capillary basement membrane kanye ne-endothelial hyperplasia, okufaka isandla ekunciphiseni ukucindezeleka komoya-mpilo kanye ne-hypoxia. I-ischemia ye-neuronal iyisici esiqinisekisiwe se-neuropathy yesifo sikashukela. Izidakamizwa zokuvula imithambo yegazi isib., Ama-ACE inhibitors, ama-α1-antagonists kungaholela ekuthuthukisweni okukhulu kokugeleza kwegazi kwe-neuronal, ngokuhambisana nokuthuthukiswa kwejubane lokuhamba kwegazi. Ngakho-ke, ukungasebenzi kahle kwem  <response>: ukugeleza kwegazi okwanele 