<prompt> Fingqa isihloko: Ukwelashwa kokuqala okuklanyelwe ngokukhethekile ukwelapha i-migraine kuye kwasungulwa - intuthuko ochwepheshe abathi ibaluleke kakhulu. Umjovo omusha unikeza ithemba emakhulwini ezinkulungwane zabantu abahlushwa ikhanda elibuhlungu elihlala likhala - uhlobo lwekhanda olukhungathekisa kakhulu. Umjovo wenziwe ngamaprotheni egazi angamakhemikhali. Lawa ama-antibody - amaprotheni akhiqizwa umzimba ukuze alwe nomjovo - aklanyelwe ngokukhethekile ukulwa namakhemikhali abangela i-migraine. Lezi zinhlanganisela zamaprotheni ziyakwaziukusula elinye iphrotheni elibizwa ngokuthi i-calcitonin gene- related peptide CGRP, elibangela ubuhlungu, isicanucanu nokuhlanza okuhambisana ne-migraine. Umjovo omusha wokuvimbela i-migraine uthuthukiswe okokuqala ngqa, entuthukweni ochwepheshe abayibiza ngokuthi ngokusha Ekuvivinyweni kwabagulayo abangu-172, ososayensi bathole ukuthi umjovo ulethe ukunciphisa okukhulu enanini lamahora nezinsuku iziguli ezinesifo esingamahlalakhona se-migraine ezihlushwa yikhanda. I-International Headache Society ichaza i-migraine engapheli ngokuthi izinsuku ezingaphezu kwezingu-15 zokuba nekhanda elibuhlungu ngenyanga phakathi nenkathi yezinyanga ezintathu - ezingaphezu kwezingu-8 - uma kungatholakali ukuthi ikhanda elibuhlungu libangelwa ukusetshenziswa ngokweqile kwemithi. I-migraine iyinhloko ebuhlungu ephindaphindayo, evame ukuthinta uhlangothi olulodwa lwekhanda, ebonakala ngobuhlungu obubukhali futhi evame ukuhambisana nesicanucanu, ukuhlanza, nokuphazamiseka kokubona. Ngokwe-World Health Organization WHO, abantu abadala abangamaphesenti amane emhlabeni wonke banekhanda izinsuku ezingu-15 noma ngaphezulu ngenyanga. Uye waveza ukuthi i-migraine engapheli ibangela ukukhubazeka okukhulu kunobumpumputhe, i-paraplegia angina noma i-rheumatoid arthritis. Futhi iye yahlukanisa i-migraine ezingeni elifanayo lokukhubazeka njengokuwohloka komqondo, i-quadriplegia kanye ne-acute psychosis. Futhi i-WHO ixwayisa ngokuthi abantu abane-migraine noma izinhlungu zekhanda ezinzima banamathuba aphindwe kathathu okucindezeleka kunabantu abaphilile. Inhlangano enikeza usizo i-Migraine Trust ithi lokhu kungabangela ukuba ngokuvamile abagulayo bacindezeleke futhi bangakwazi ukubhekana nesimo. Nakuba amathonya angaphakathi noma angaphandle engase...  <response>: I-migraine ibangelwa i-calcitonin gene-related peptide CGRP iprotheni. Lokhu kwandisa imithambo yegazi eseduze nezinzwa ekhanda, okubangela ubuhlungu. Umjovo omusha uqukethe amaprotheni egazi ane-monoclonal. Lawa ama-antibody aklanyelwe ukubopha i-CGRP futhiangayihlanza Ucwaningo lwathola ukuthi ukwelashwa kwanciphisa ngokuphawulekayo ukuphathwa ikhanda kwabagulayo. 