<prompt> Yikuphi okulandelayo okungeyona imiphumela emibi: ukukhuluphala, ukuvuvukala noma i-osteoporosis? Njengoba kunikezwe umbuzo odlule, bhala umongo onempendulo yawo. Kungaba imisho engu-1 kuya kwengu-20. Umongo:  <response>: Imithi elwa nokuvuvukala ivame ukusetshenziselwa ukulawula imiphumela yokuvuvukala. Ama - glucocorticoid anamandla kakhulu kulezi zidakamizwa; kodwa, lezi zidakamizwa zingaba nemiphumela eminingi engathandeki, njengokukhuluphala okuphakathi, i - hyperglycemia, i - osteoporosis, futhi ukusetshenziswa kwazo kumelwe kulawulwe ngokuqinile. Imithamo ephansi yemithi elwa nokuvuvukala ivame ukusetshenziswa kanye nemithi ebulala amagciwane noma ecindezela amasosha omzimba njenge- methotrexate noma i- azathioprine. Imithi enobuthi bamangqamuzana ivimbela ukusabela kwamasosha omzimba ngokubulala amangqamuzana ahlukanisayo njengamangqamuzana e-T asebenzayo. Nokho, ukubulawa kwawo akuhlukanisi futhi amanye amangqamuzana ahlala ehlukana nezitho zawo kuyathinteka, okubangela imiphumela emibi enobuthi. Imithi ecindezela amasosha omzimba njenge-cyclosporin ivimbela ama-T cell ukuba aphendule kahle kumasignali ngokuvimbela izindlela zokudlulisa isignali. 