<prompt> Bheka isigaba esingezansi bese uphendula umbuzo emva kwalokho ngolimi olufanayo nesigaba: Isethulo: I-genome yomuntu iqukethe cishe izakhi zofuzo ezingu - 25 000 ezisebenza ngokubambisana ukuze zikhiqize amaprotheni ahlukahlukene angaba ngu - 1 000 000. Lokhu kungenxa yokuhlanganiswa okuhlukile, futhi futhi ngenxa yokuthi amangqamuzana enza izinguquko ezibalulekile kumaprotheni ngokuguqulwa kokuguqulwa ngemuva kokuwakha okokuqala, ngakho-ke i-gene elinikeziwe lisebenza njengesisekelo sezinguqulo eziningi ezingenzeka zeprotheni ethile. Kunoma ikuphi, ukuhlolwa kwe-mass spectrometry eyodwa kungakhomba cishe Umbuzo: Sibizwa ngokuthini isimo lapho amangqamuzana enza izinguquko ezibalulekile phakathi kwawo?  <response>: ukuguqulwa kwangemva kokuhumusha 