<prompt> I - genetic predisposition yokugula sekuyisikhathi eside kucatshangwa ukuthi ibalulekile.  <response>: Yiqiniso, inguqulo eyinkimbinkimbi ngokwengeziwe yomusho ithi Ukutholakala kwezifo ngokwemvelo kuye kwabhekwa njengokubalulekile isikhathi esithile, njengoba kubonakala ezimweni ze - PBC emalungwini omkhaya, ukuvumelana kwamawele afanayo, nokuhlanganiswa kwezifo ezizimele. 