<prompt> Bheka isigaba esingezansi bese uphendula umbuzo emva kwalokho ngolimi olufanayo nesigaba: Ukudlula: Ukukhulelwa kokugcina kuka-Anne kwaphela ngo-January 25, 1700 ngokubeletha umntwana ofile. Wayekhulelwe okungenani izikhathi eziyishumi nesikhombisa phakathi neminyaka eminingi, futhi wayeke wakhipha isisu noma wazala izingane ezizelwe zifile okungenani izikhathi eziyishumi nambili. Ezinganeni zakhe ezinhlanu ezazalwa ziphila, ezine zafa zingakabi neminyaka emibili ubudala. U-Anne wayehlushwa i-gout ubuhlungu emilenzeni yakhe futhi ekugcineni esiswini nasekhanda kusukela okungenani ngo-1698. Ngenxa yokulahlekelwa umbungu nezimpawu ezingokomzimba, kungenzeka ukuthi wayene-lupus erythematosus esakazekile, noma i-Hughes syndrome. Ngakolunye uhlangothi, isifo sokuvuvukala kwesibeletho singase sichaze ukuthi kungani ukuqala kwezimpawu zakhe cishe kwaqondana nokukhulelwa kwakhe okungemva kokugcina. Ezinye izimbangela ezicatshangelwayo zokukhulelwa kwakhe okungaphumelelanga yi - listeriosis, isifo sikashukela, ukuphazamiseka kokukhula ngaphakathi kwesibeletho, nokungavumelani kwe - rhesus. Kodwa-ke, ukungahambisani kwe-Rhesus kuvame ukuwohloka ngokukhulelwa okulandelanayo, ngakho-ke akuhambisani nesitayela sokukhulelwa kuka-Anne, njengoba okuwukuphela kwendodana yakhe eyasinda ebuntwaneni, iNkosana uWilliam, uMbusi waseGloucester, yazalwa ngemuva kochungechunge lokuzalwa kwesidumbu. Ochwepheshe baphinde bakhiphe isifo sofuba, i-porphyria nokushwabana kwesibeletho njengokungavumelani nomlando wakhe wezokwelapha. Umbuzo: Abantu bathi yini eyayibangela ukukhulelwa okungaphumelelanga?  <response>: i- listeriosis, isifo sikashukela, ukuphazamiseka kokukhula ngaphakathi kwesibeletho, nokungahambisani kwe- rhesus 