<prompt> Bheka isigaba esingezansi bese uphendula umbuzo emva kwalokho ngolimi olufanayo nesigaba: Ukudlula: Ngekhulu le-19 nele-20, ngaphambi kokuba ukwelashwa okuphumelelayo kwe-pharmacological kwe-hypertension kwenzeke, izindlela ezintathu zokwelashwa zazisetshenziswa, zonke zinemiphumela emibi eminingi: ukuvinjelwa okuqinile kwe-sodium ngokwesibonelo ukudla kwelayisi, i-sympathectomy ukususwa kokuhlinzwa kwezingxenye zesistimu yezinzwa, kanye nokwelashwa kwe-pyrogen umjovo wezinto ezibangela umkhuhlane, ngokunciphisa ngokungaqondile umfutho wegazi. Ikhemikhali yokuqala ye-hypertension, i-sodium thiocyanate, yasetshenziswa ngo-1900 kodwa yayinemiphumela eminingi emibi futhi yayingavamile. Ngemva kweMpi Yezwe Yesibili kwenziwa ezinye izidakamizwa eziningana, ezithandwa kakhulu futhi eziphumelelayo kwakuyi - tetramethylammonium chloride, i - hexamethonium, i - hydralazine, ne - reserpine etholakala esitshalweni sokwelapha i - Rauwolfia serpentina. Akukho kulokhu okwakubekezelelwa kahle. Ukugqashuka okukhulu kwafezwa ngokutholakala kwezidakamizwa zokuqala ezamukelwa kahle ezisetshenziswa ngomlomo. Eyokuqala kwakuyi - chlorothiazide, i - thiazide diuretic yokuqala futhi yasungulwa nge - antibiotic sulfanilamide, eyaqala ukutholakala ngo - 1958. Ngokulandelayo, ama-beta blockers, ama-calcium channel blockers, ama-angiotensin converting enzyme ACE inhibitors, ama-angiotensin receptor blockers, nama-renin inhibitors athuthukiswa njengama-antihypertensive agents. Umbuzo: Yimuphi umuthi otholakala esitshalweni iRauwolfia?  <response>: isidleke 