<prompt> Yakha inguqulo eyinkimbinkimbi yalesi sigwebo Izinqubo ezimbili zenza ama-antigen ukuba ashintshe: i-antigenic drift kanye ne-antigenic shift.  <response>: Yiqiniso, inguqulo eyinkimbinkimbi yalesi sigwebo ithi Izinqubo ezimbili zenza ama-antigen ashintshe: ukudonseka kwe-antigen nokushintshwa kwe-antigen, ukudonseka kwe-antigen okuvame kakhulu. 