<prompt> Fingqa isihloko: Umuthi omusha, obizwa ngokuthi ibrutinib, ocima umdlavuza ngokushesha ungase unikezwe iziguli ezinezimo ezithile zesifo. Isithombe sesitoko. Kungase kunikezwe ngokushesha iziguli ezinezimo ezithile zesifo isidakamizwa esiguqula isimo sezokwelapha esicisha umdlavuza. Uma kunqunyiwe, ithebhulethi ethathwa kanye ngosuku, ebizwa ngokuthi ibrutinib, ingasindisa iziguli ezinomdlavuza wegazi emiphumeleni emibi ngezinye izikhathi ebulalayo yokwelapha ngamakhemikhali okuvamile. I-ibrutinib ingenye yemithi emisha embalwa ezotholakala nge-Cancer Drugs Fund ngemuva kokuhlolwa okubili ezibhedlela zaseBrithani ezingu-28 okubonisa ukuthi iyasebenza kakhulu ekwelapheni kokubili i-mantle cell lymphoma MCL kanye ne-chronic lymphocytic leukemia CLL. UProfesa Stephen Devereux, ongudokotela wezifo ezibangelwa igazi e-Kings College Hospital eLondon, uthi kuyisigaba esisha semithi ehlosiwe, eyaziwa ngokuthi i-Brutons tyrosine kinase inhibitor. Isebenza ngokuqondisa nokucisha iprotheni emangqamuzaneni omdlavuza. Ukwelashwa ngamakhemikhali kubulala amangqamuzana omdlavuza kodwa futhi kubulala namangqamuzana ajwayelekile ngakho-ke kunemiphumela eminingi emibi, kusho yena. Njengoba lo muthi ubhekiswe kumaseli e-B, imiphumela emibi incane. Ngaphezu kwalokho, iziguli akudingeki ukuba ziye esibhedlela ukuze zinikezwe lona. Cishe umuntu oyedwa kwabangu-25 uzothola ukuthi unomdlavuza wegazi phakathi nesikhathi sokuphila kwakhe - lokho kusho abantu abangu-25 000 unyaka ngamunye e-UK. Kulaba, abangu - 2 800 bayoba ne - CLL, uhlobo oluvame kakhulu lwe - leukemia, futhi abangu - 500 bayoba ne - MCL, uhlobo olungavamile lwe - B - cell lymphoma. Okwamanje, ukwelashwa nge-ibrutinib okubiza kuze kufike ku-74,000 ngonyaka kuzonikezwa kuphela iziguli ezinesifo esingaphenduli ekwelashweni ngamakhemikhali, noma lezo eziye zabuyela emuva ngemva kokwelashwa ngamakhemikhali. Kodwa kwenziwa nezivivinyo kusetshenziswa lo muthi njengendlela yokwelapha yokuqala. UProfesa Devereux uthi: Sibheke phambili esikhathini esizayo lapho kungasadingeki khona ukwelashwa ngamakhemikhali, nakuba singakafiki lapho. Lesi sidakamizwa sithatha isifo esihlaselayo bese sisenza sibe esingenangozi. Akulona ikhambi - lezi zifo azinakwelashwa - kodwa kuzenza zibe yizifo ezingalapheki. Sesivele sazi ukuthi kungasebenza eziningana...  <response>: U-Ibrutinib uzotholakala nge-Cancer Drugs Fund ngemuva kwezilingo ezimbili. Izivivinyo, ezibhedlela ezingama-28 zaseBrithani, zabonisa ukuthi ziphumelela kakhulu ekwelapheni i - mantle cell lymphoma kanye ne - chronic lymphocytic leukemia. Okwamanje, i-ibrutinib ebiza kuze kufike ku-74,000 ngonyaka izonikezwa kuphela iziguli ezinesifo esingaphenduli ekwelashweni ngamakhemikhali. 