<prompt> Qedela umusho olandelayo:  <response>: Ukuqubuka kwekholera ngo-1854 eBroad Street kwaba ukuqubuka okukhulu kwekholera okwenzeka ngo-1854 eduze neBroad Street manje eyiBroadwick Street esifundeni saseSoho eLondon, eNgilandi, futhi kwenzeka ngesikhathi sobhadane lwesithathu lwekholera. Lolu bhubhane, olwabulala abantu abangu - 616, lwaziwa kakhulu ngokucwaninga kukadokotela uJohn Snow ngezimbangela zalo nangombono wakhe wokuthi amanzi angcoliswe amagciwane ayewumthombo wekholera, hhayi izinhlayiya ezisemkhathini ezibizwa ngokuthi i - miasma. 