<prompt> Fingqa isihloko: Ochwepheshe baye babhekisela kumuthi oncibilikisa amafutha ngaphandle kobuhlungu ngokuthi umuthi wokuphakamisa amehlo ebhodleleni. Ukwelashwa okwaziwa kuphela ngegama layo lokuhlola i-XAF5 kuye kwaboniswa ukuthi kunciphisa kakhulu izikhwama ezingaphansi kwamehlo. Abenzi bayo bathi ingase isetshenziselwe nokuncibilikisa izinsini eziphindwe kabili futhi ingasetshenziswa ngisho nasemzimbeni, ikakhulukazi emafutheni esiswini. Lokhu kunconywa kulandela umhlangano waminyaka yonke we-American Academy of Dermatology, lapho inkampani yase-US ye-bio-tech iTopokine Therapeutics yaveza khona imininingwane yokuhlolwa kweziguli ezingu-90 ezineminyaka ephakathi kuka-40 no-70, ezazisebenzisa ukhilimu kanye ngosuku endaweni engaphansi kwamehlo amasonto ayishumi. Skrolela phansi ukuze ubone ividiyo. Ukwelashwa, okwaziwa kuphela ngegama layo lokuhlola elithi XAF5, kuye kwaboniswa ukuthi kunciphisa kakhulu izikhwama ezingaphansi kwamehlo. Isithombe sesitoko. Lolu cwaningo lwaluyimpumputhe kabili futhi lulawulwa nge-placebo, okusho ukuthi ababambiqhaza nabacwaningi babengazi ukuthi yibaphi abagulayo ababengamalungu eqembu lokulawula noma iqembu lokuhlola. Amaphakethe ahlukaniswa ngesilinganiso samaphoyinti amane, futhi ekuhlolweni okunikezwe odokotela abazimele, ngaphansi nje kwengxenye yalabo abasebenzisa i-XAF5 kwatholakala ukuthi bathuthuke ngesilinganiso esisodwa esigcwele kuwo womabili amehlo, kanti abanye babona ukuthuthuka okungu-degree amabili. UDkt. Michael Singer, isikhulu sesayensi yeTopokine, uthe: Ukukhula okungu-degree elilodwa kungase kuzwakale kuncane, kodwa kuwushintsho olubalulekile. Abahlanganyeli bathi bazizwa bebukeka besebasha, bekhanga futhi bephumule kangcono ngemva kokwelashwa. Izikhwama zamehlo, noma i-steatoblepharon, ziyizikhwama ezinamafutha ngaphansi kwegumbi lamehlo ezivuleka phambili. Nakuba izici eziningi, kuhlanganise nokuntula ubuthongo nokungezwani komzimba, kungaholela ekuqongeleleni uketshezi kulezi zinhlayiya, ngokuvamile ziyingxenye ehlala njalo yesakhiwo sobuso. Ukubukeka kwawo kuya kuba kubi njengoba umuntu ekhula njengoba izibopho eziqinisa lezi zibambo ziba buthakathaka. Lapho isetshenziswa, i-XAF5 idonswa ngesikhumba futhi ingene ezicutshini ezinamafutha. Ibopha ama-receptor asezingxenyeni zamangqamuzana amafutha, ibangele ukuba akhiphe amafutha akuwo, anciphise usayizi wawo. Ibuye ivimbele ukwakheka kwamangqamuzana amasha amafutha. Abenzi bakhi bathi kungenzeka futhi ukuthi...  <response>: Ukwelashwa okwaziwa kuphela ngegama layo lokuhlola i - XAF5 kuye kwaboniswa ukuthi kunciphisa kakhulu izikhwama ezingaphansi kwamehlo. Yahlolwa ezigulini ezingu-90 ezazisebenzisa ukhilimu kanye ngosuku amasonto ayishumi. Abenzi bayo bathi ingase isetshenziswe ngisho nasemzimbeni, ikakhulukazi emafutheni esiswini. 