<prompt> Bheka isigaba esingezansi bese uphendula umbuzo emva kwalokho ngolimi olufanayo nesigaba: Ukudlula: Inani le-ADI lisekelwe ocwaningweni lwamanje, ngezifundo zesikhathi eside ezilwaneni nasekubhekeni abantu. Okokuqala, kunqunywa izinga elingenawo umthelela omubi NOAEL, inani lezinto ezingabonisi imiphumela enobuthi. Ngokuvamile lezi zifundo zenziwa ngemithamo eminingana kuhlanganise nemithamo ephezulu. Endabeni yezifundo eziningana zemiphumela ehlukene, i-NOAEL ephansi kakhulu ivame ukuthathwa. Khona-ke, i-NOAEL noma elinye iphuzu lokuqala njengamazinga omthamo wokulinganisa i-BMDL lihlukaniswa nge-factor yokuphepha, ngokuvamile eyi-100, ukuze kucatshangelwe umehluko phakathi kwezilwane ezihlolwayo nabantu isici esingu-10 kanye nokwehluka okungenzeka ekuzweleleni phakathi kwabantu enye i-factor engu-10. Amaphuzu okuphepha anamanani ahlukile ku-100 angasetshenziswa uma ulwazi lokungaqiniseki mayelana nenani lephuzu lokuqala i-NOAEL noma i-BMDL likufanele. Ngokwesibonelo, uma i-ADI isekelwe olwazini oluvela kubantu, isici sokuphepha ngokuvamile siba u-10 esikhundleni sika-100. I-ADI ivame ukunikezwa ngo-mg ngekg yesisindo somzimba. I-ADI ibhekwa njengezinga lokudla eliphephile kumuntu omdala onempilo onesisindo esivamile odla inani eliphakathi nendawo nsuku zonke lale nto okukhulunywa ngayo. Kuye kwaxoxwa ngezici zokuphepha ezengeziwe ezinganeni, kodwa azidingeki, ngoba empeleni ukukhishwa kwamakhemikhali kuvame ukushesha kakhulu ezinganeni futhi njengoba izingane ngokuvamile zihlushwa amazinga aphezulu okugula kunabantu abadala, imiphumela emibi ebangelwa izithasiselo zokudla ingafihlwa kalula njengezinto eziningi izingane ezivame ukuhlushwa yizo. Kungaba nzima kakhulu ukuphikisana nomuntu omdala onempilo. I-ADI ayizicabangeli izimpawu zokungezwani komzimba okuyizimpawu zomuntu ngamunye kunezimo ezixhomeke kumthamo. Umbuzo: Cishe kusetshenziswa imithamo emingaki kulezi zivivinyo?  <response>: eziningana 