<prompt> Qedela umusho olandelayo: Ukuguqulwa kwezimboni ngawo-1700 kwaletha inqwaba yezinkinga ezintsha zezempilo yomphakathi ezazibangelwa ukuthuthuka okusheshayo kwamadolobha nokungalingani kahle kwezempilo, okuyizimo ezashukumisa ukuthuthukiswa kokuhlelwa kwamamephu ezifo, noma ukuhlelwa kwamamephu ezokwelapha. I-medical cartography, eyandulela i-medical geography, yavela ngenxa yesidingo sokuxhumana ngokungafani kwendawo engozini yezifo ezingaziwa imbangela yazo, ikakhulukazi ukuqubuka kwamakholera nomkhuhlane ophuzi emadolobheni. Omunye wabantu abavelele kunabo bonke kokubili emkhakheni wezifo eziwumshayabhuqe nakwezokwelapha uJohn Snow, udokotela owakhomba ngokunembile umthombo wokuchayeka phakathi  <response>: Ukuqubuka kwekholera ngo-1854 eBroad Street. Ibalazwe likaSnow elidumile lika-1854 lokuqubuka kwekholera libonisa ngokusobala ukuthi amacala ayeqoqene eduze kwepompo yaseBroad Street, umthombo wamanzi angcolile owabangela ubhadane. Lelibalazwe laholela uSnow ukuba athole ipompo elalingcolisiwe futhi aphethe ngokuthi ikholera yayiyisifo esidluliselwa ngamanzi, okuyinto ephawulekayo uma kucatshangelwa ukuthi isayensi yayingazi lutho ngamabhaktheriya ngaleso sikhathi. Nakuba iqhaza likaSnow ekwakhiweni kwezwe kwezokwelapha nasekufundeni ngemikhuhlane lingenakuphikwa, indima yebalazwe kulolu cwaningo oluthile iye yagcizelelwa ngandlela-thile. Amamephu amachashazi amacala akhiqizwa ngesikhathi sezimboni ayeyizinto ezinamandla ekudluliseni okutholakele kokulinganisa okujwayelekile kokubhekana nezifo, kodwa indima yawo njengamathuluzi okuhlaziya yayikhawulelwe ngenxa yemikhawulo yezobuchwepheshe. 