<prompt> Yakha inguqulo eyinkimbinkimbi yalesi sigwebo I-arsenic, i-chromium, insimbi, ne-nickel kungenzeka zihlobene nokukhiqizwa kwezinhlobo zomoya-mpilo ezisebenzayo, futhi ezinye zazo zingase futhi zishintshe ubuqotho bokuphindaphindeka kwe-DNA.  <response>: Yiqiniso, inguqulo eyinkimbinkimbi yomusho ithi I-Arsenic, i-chromium, insimbi, ne-nickel kungase kuhlotshaniswe nokukhiqizwa kwezinhlobo zomoya-mpilo ezisebenzayo, i-nickel nayo ingahlotshaniswa ne-DNA hypermethylation ne-histone deacetylation, kuyilapho i-cadmium ingavimbela ukulungiswa kokungafani kwe-DNA. 