<prompt> Qedela le nkulumo elandelayo: U - Israel Kleiner, owayesebenza eRockefeller Institute for Medical Research phakathi kuka - 1915 no - 1919, wabika ngemiphumela ekholisayo ngomphumela wesisombululo se - pancreas esigaywe emazingeni kashukela egazini, esebenzisa ukulawula okuqinile kokuhlola ngokombono... okusekela umbono wokukhishwa kwangaphakathi kwemvelaphi yesifo sikashukela futhi ngokuyisisekelo... okusikisela ukusetshenziswa okungase kube khona kwezokwelapha. Wawuyeka lo msebenzi lapho eshiya iRockefeller institute ngo - 1919, ngenxa yezizathu ezingaziwa ngokucacile. Usosayensi waseRomania uNicolae Paulescu, omunye umuntu ovelele ekufuneni into elwa nesifo sikashukela, waqala ukuhlola ngo-1916 esebenzisa isixazululo se-pancreatic esinosawoti omncane njengoKleiner. Ngemva kokuphazamiseka  <response>: Ebhekene neMpi YaseBucharest kanye nezinxushunxushu zangemva kwempi, washicilela imiphumela yakhe yokuqala ngesiFulentshi ngo-1920 nango-1921. Izithasiselo zakhe zaholela ekunciphiseni okucacile kwegazi noshukela womchamo ezinjeni ezihloliwe, kodwa zazingenawo umphumela osheshayo ezigulini zakhe ezingabantu ngomjovo we-rectal owawungeke uphindwe ngemithamo yomjovo womzimba kuphela. UPaulescu wathola ilungelo lobunikazi laseRomania ngesixazululo sakhe asibiza ngokuthi pancréine nendlela yokukhiqiza, kodwa ngonyaka olandelayo, akazange athuthuke emsebenzini wakhe ngenxa yokuntuleka kwemali. 