 Nyorai kuenderera mberi kweiyi ndima - Akadzokera kunharaunda yake, apera simba nemakore makumi maviri ehondo, achikurudzira kumuka kwetsika nehupfumi. Francesco akarwa muHondo yeBicocca, parutivi pomutongi, muna 1522. Muna 1526 akachinja mativi, achibatanidzwa neLiga yeCognac, pamwe naFrancis I weFrance, Papa Clement VII neRepublic of Florence, uye akakombwa muCastello Sforzesco. 