 Nyorera kuenderera kweiyi ndima - Mushure mekukunda FIDE Grand Prix 201415, Caruana akakodzera kumakwikwi e2016 Candidates Tournament, kwaakanga ari wechipiri kuna Sergey Karjakin. Akakunda 2016 US Chess Championship, uye akamiririra US pa 42nd Chess Olympiad, kuhwina chikwata goridhe uye munhu nendarira. Akakunda muna 2017. Akakunda Candidates Tournament 2018, achiva muAmerica wekutanga kupokana neWorld Chess Championship kubvira Bobby Fischer muna 1972. Mukumhanya-mhanya kumakwikwi emakwikwi, Caruana akakunda yechishanu Grenke Chess Classic, yechitanhatu Norway Chess, uye yechitanhatu Sinquefield Cup. Akarasikirwa nemutambo uyu naMagnus Carlsen mumakwikwi ekukurumidza mushure mekunge aenzana 66 mumitambo yechinyakare. 