 Nyorai kuenderera mberi kweiyi ndima - Theodore akaberekwa naMambo John III Doukas Vatatzes naIrene Laskarina mumuzinda wamambo muNicaea mukupera kwa1221 kana kutanga kwa1222. Irene akanga ari mwanasikana mukuru waTheodore I Laskaris, muvambi woUmambo hweNicaea. Nicaea yaiva nyika yakatsiva Umambo hweByzantium, hwakagadzwa pashure pokunge vapanduki veRoma vokuEurope yokumadokero vaLatin vatora Constantinople mukati meChitatu cheCrusade muna 1204. Vatatzes aiva murume waIrene wechitatu. Akaberekerwa mumhuri yeByzantine ine mukurumbira ine ukama neumambo hweumambo hwaKomnenos naAngelos. Paakaroora Irene, akanga ari mukuru mukuru wevarindi vomumambo. Kunyange zvazvo vakoma vaviri vaIrene vakanga vafa nguva isati yakwana, Theodore I haana kudana Vatatzes kuti ave mugari wenhaka wake wepamutemo. Sezvingabvira zvikuru aikarira kuti mudzimai wake wechitatu, Maria wechiLatin weCourtenay, aizobereka vanakomana, asi iye haana kubereka vana naye. Theodore I akafa muna November 1221. Vatatzes aifanira kukunda vakoma vomumambo vainge vashaya, Alexios naIsaac Laskaris, kuti atore chigaro choumambo. Kukunda kwake vanasekuru vomudzimai wake nevavakidzani vavo vokuLatin muHondo yePoimanenonmuchando cha12231224 akazarura nzira yokukundazve nyika dzeByzantium dzakaraswa kuvaLatin muAsia Minor. 