 Pashure pokunge United States yapinda muHondo Yenyika II, General George C. Marshall akagovera Eisenhower kuWar Plans Division muWashington, D.C. Eisenhower akava mutungamiriri wemauto eAmerica muBritain muna June 1942 uye akagoverwa kutungamirira Operation Torch, kudenha kweAllied kweFrench North Africa. Pashure pokubudirira kweOperation Torch, Eisenhower akatungamirira kukunda kweAllied muTunisia, achimanikidza mauto ose eAxis kuti azviise muna May 1943. Eisenhower akatungamira matanho okutanga ehondo yeItaly, asi akazosarudzwa kuti atungamirire Allied invasion yeWestern Europe muna December 1943. Akashanda semutungamiri mukuru weOperation Overlord, Allied invasion yeNormandy, uye akatungamira mashandiro akazotevera muFrance. Zvichitevera kubudirira kweOperation Overlord, maAllies akakurumidza kudzora chikamu chikuru cheWestern Europe, asi maGerman akatanga kurwisa kukuru muhondo yeBulge. Kuramba kweGermany kwakakurumidza kuparara zvichitevera kukunda kweAllied muhondo iyoyo, uye Eisenhower akagamuchira kuzvipira kweGermany muna May 1945. 