 Pence akatsigira Iraq War Resolution, iyo yakapa mvumo yekuita zvechiuto kuIraq. Munguva yeHondo yeIraq, Pence akaramba kugadza zuva rekubva muIraq. Mukati mekushanya kwaApril 2007 kuBaghdad, Pence naJohn McCain vakashanyira musika weShorja, nzvimbo yekurwiswa kwakauraya munaFebruary 2007 uko kwakanga kwangouraya vanhu 61. Pence naMcCain vakarondedzera shanyo yacho souchapupu hwokuti kuchengeteka mumisika yeIraq kwakanga kwavandudzika. Kushanya kumusika kwakaitika pasi pekuchengetedzwa kwakasimba, kusanganisira maherikoputa ari pamusoro, uye New York Times yakashuma kuti kushanya kwacho kwakapa chiratidzo chisiri chechokwadi chekuti nzvimbo yacho yaive yakachengeteka zvakadii nekuda kwemauto akaomarara ekuchengetedza anodzivirira McCain. Pence akatungamira House Foreign Affairs Subcommittee kuMiddle East uye aive mutsigiri akakurumbira weGeorge W. Bushs Iraq War mauto ekuwedzera muna 2007. Panguva iyoyo, Pence akati kuwedzera kuri kushanda uye akadzivirira chisarudzo chokutanga chokupinda muna 2003. 