 Serginho pakutanga akatanga basa rake rebhora munyika yake, uye akatamba makirabhu eCruzeiro EC, Bahia, uye São Paulo FC. Akatamira kuItaly A.C. Milan muna 1999, kwaakatanga ari mutambi wepedyo, achitanga pabhenji asi kazhinji ari wekutanga-sarudzo. Musoro webasa raSerginho reMilan ndipo paakarova zvibodzwa uye akapa rubatsiro rwezvitatu mukukunda 6-0 kwevanokwikwidza veCrosstown Internazionale musi wa11 Chivabvu 2001. Akabatsirawo kuMilans 2003UEFA Champions League kukunda Juventus, achihwina wekutanga weMilans matatu akabudirira penalty mu shootout. Mumakwikwi ekupedzisira eChampions League muna 2005 zvinhu zvakachinja, Milan yakasiya 3-0 ichitungamirira Liverpool, Serginho achiridza muridzo pamusoro pemutsara. Serginho akahwinawo 2003-04 Serie A zita neMilan uye 2006-07 edition yeEFAFA Champions League, pakati pemamwe makwikwi. 