 Nyorai mberi kweiyi ndima - C-17s yakapa zvinhu zvechiuto panguva yeOperation Enduring Freedom muAfghanistan uye Operation Iraqi Freedom muIraq pamwe nemabasa ekubatsira vanhu pakarepo mushure mekudengenyeka kwenyika kweHaiti muna 2010, mafashama eSindh muna 2011 achiendesa zviuru zvezvokudya, matani ezvokurapa uye zvekukurumidzira. Pana 26 March 2003, 15 USAF C-17s vakapinda mukurusa airdrop kurwa kubva United States nechisimba Panamamuna December 1989: kudonhedzwa mudenga usiku kwevarwi veparachuti vane chiuru kubva ku173rd Airborne Brigade kwakaitika pamusoro peBashur, Iraq. Kuburitswa kwemaparachute kwakateverwa neC-17s dzakatakura M1 Abrams, M2 Bradleys, M113s nepfuti. USAF C-17s vavewo kushandiswa kubatsira vavakidzani vavo airlift zvinodiwa, kusanganisira Canadian motokari kuAfghanistan muna 2003 uye Australian mauto panguva Australian-akatungamirira muchiuto deployment kuEast Timor muna 2006. Muna 2006, USAF C-17s yakabhururuka 15 Canadian Leopard C2 matangi kubva kuKyrgyzstan kuenda kuKandahar mukutsigira basa reNATO muAfghanistan. Muna 2013, vashanu USAF C-17s vakatsigira mashandiro French muMali, kushanda nedzimwe nyika C-17s RAF, NATO uye RCAF deployed rimwe C-17 mumwe. 