 Nyorera kupfuurira kweiyi ndima - Pakazosvika 1804, Mutevedzeri weMutungamiri Burr akanga atsausa zvakakwana Jefferson, uye Democratic-Republican presidential nominating caucus yakasarudza George Clinton semumiriri waJefferson musarudzo yemutungamiri wenyika ya1804. Gore iroro, Burr akakwikwidza Hamiltonpashure pokugumburwa nemashoko anonzi akataurwa naHamilton; Hamilton akafa mukurwa kwakazotevera. Akasimbiswa nesangano rebato rakakwirira, Jefferson akakunda musarudzo ya 1804 mukukunda kukuru pamusoro pomumiriri weFederalist Charles Cotesworth Pinckney. Muna 1807, sezvo Hondo dzaNapoleon dzakapfuurira, vaBritain vakazivisa Mirayiro muDare, iyo yaidaidzira kurambidzwa kweUmambo hweFrance. Mukupindura kurwiswa kwakazoitwa ngarava dzeAmerica neBritain neFrance, hurumende yaJefferson yakapa Mutemo weEmbargo muna 1807, uyo wakabvisa kutengeserana neEurope. Chibvumirano chacho chakaratidza kuva chisingafarirwi uye chakaoma kuita kuti chiitwe, zvikurukuru muNew England ine maFederalist, uye chakapera pakupera kwetemu yechipiri yaJefferson. Jefferson akaramba kutsvaka nguva yechitatu musarudzo yemutungamiri wenyika ya1808, asi akabatsira Madison kukunda George Clinton naJames Monroe paCongressional nominating caucus yebato. Madison akakunda musarudzo huru nechiverengero chikuru chaPinckney. 