 Nyorai kuenderera mberi kweiyi ndima - Palou akasainwa neChip Ganassi Racing kuti atyaire No. 10 Honda yemwaka wa2021 IndyCar Series. Musi wa18 Kubvumbi 2021, Palou akawana kukunda kwake kwekutanga kweIndyCar Series mujaho wekuvhura mwaka kuBarber Motorsports Park. Palou akawedzera imwe podium yemwaka kuGMR Grand Prix. Palou akapedza wechipiri mu2021 Indianapolis 500Kukunda kwechina kwaHélio Castroneves. Kuguma kwaPalou munhangemutange ye500 kwakamuita kuti atungamirire mumakwikwi aya. Palou akazoenderera mberi nekumhanya kwepodiyamu mushure memakumi mashanu, kunyangwe akarasikirwa kwenguva pfupi nemapoinzi anotungamira kuna Pato OWard muDetroit I. Palou akapedza wechitatu mujaho wechipiri muDetroit, akakunda kuRoad America mushure mekunge Josef Newgarden atambura nekutadza kwegiya bhokisi, uye akapedza wechitatu kuMid Ohio kuti asimbise mapoinzi ake anotungamira mukwikwidzi pamusoro paScott Dixon naOWard. Palou akanga ane kukundikana kweinjini munharaunda yechipiri paIndianapolis Road Course. Akabva asiya pfungwa dzaitungamirira kuna OWard pashure pokunge iye naDixon vaunganidzwa mutsaona yakakonzerwa naRinus VeeKay paGateway. 