 Nyorai kuenderera mberi kweiyi ndima - Inozivikanwa seSerdica muAntiquity uye Sredets muMiddle Ages, Sofia yave iri nzvimbo yekugara kwevanhu kubvira angangoita 7000 BC. Nhoroondo yakanyorwa yeguta inotanga nekupupurirwa kwekukunda kweSerdika neRepublic yeRoma muna 29 BC kubva kuCeltdzinza ravaSerdi. Mukati mokuderera kwoUmambo hweRoma, guta racho rakapambwa navaHuns, vaVisigoth, vaAvars navaSlav. Muna 809 Serdica yakabatanidzwa muUmambo hweBulgaria naKhan Krum uye yakazozivikanwa seSredets. Muna 1018, vaByzantine vakapedza kutonga kweBulgaria kusvika muna 1194, apo yakabatanidzwazve neUmambo hweBulgaria hwakanga hwazvarwa patsva. Sredets yakava muzinda mukuru wehurumende, wezvoupfumi, wetsika uye wokunyora kusvikira yakundwa nevaOttoman muna 1382. Kubva muna 1530 kusvika muna 1826, Sofia yaiva guta guru reRumelia Eyalet, dunhu guru reUmambo hweOttoman muEurope. Kutonga kweBulgaria kwakadzorerwa muna 1878. Sofia yakasarudzwa kuti ive guta guru reHurumende yechitatu yeBulgaria mugore rakatevera racho, zvichitanga nguva yokukura kukuru kwevanhu uye kwoupfumi. 