 Nyora kupfuurira kweiyi ndima - Muna 1533, akatamira kuRoma, achiva mutsigiri weconsi-sorial. Akanga akaroorwa naAntonina Capodiferro, hanzvadzi yaKardinal Girolamo Recanati Capodiferro uye aive nemwanakomana. Pashure pokunge Antonia afa, Mignanelli akapinda muchechi. Muna 1537, akatumwa semumiriri kuRepublic of Venice kuti akurudzire Venice kuputsa mubatanidzwa wayo neOttoman Empire uye kuenda kuhondo neOttomans. Muna October 1537, Pope Paul III akamutumira somumiriri kuna Charles V, Mambo weRoma Tsvene kuti amupe gwaro rokumisa Dare reTrent kechipiri. Muchirimo cha1538, akaenda kuNice naPapa kunotaurirana kupera kweHondo yeItaly ya15361538Nguva pfupi pashure pacho, vakaenda kuGeneva kunosangana namambo. Musi waSeptember 3, 1538, akagadzwa kuva mumiririri waFerdinand, Mambo weRoma, achibata chinzvimbo ichi kusvikira muna 1539. Muna 1540, akava muongorori weRoman Rota. Iye akanga ariwo muapostora anotungamirira uye mufundisi womumba wapapa. 