 Ramba uchinyora ndima iyi - Kukwidziridzwa kwaCharles weSpain kuva Mambo Mutsvene weRoma, chinzvimbo icho Francis akanga ada, kwakatungamirira kukuparara kweukama pakati peFrance neHabsburgs. Muna 1519, Spain yakapinda muNavarre, iyo yainzi yaiva nharaunda yeFrance, ikapa Francis chikonzero chokutanga hondo huru; mauto eFrance akazara muItaly ndokutanga hondo yokudzinga Charles muNaples. Zvisinei, vaFrench vakakundwa nemauto eSpanish akanga ashanda zvakakwana, uye vakakundwa zvine mutsindo paBicoccauye Sesia kurwisa mauto eSpain aFernando dAvalos. Milan pachayo payakanga yava kutyisidzirwa, Francis pachake akatungamirira uto reFrance kupinda muLombardy muna 1525, asi akakundwa ndokutorwa muhondo yePavia; akaiswa mutorongo muMadrid, Francis akamanikidzwa kubvuma kubvuma kwakakura kumatunhu ake eItaly mu Chibvumirano cheMadrid 1526. 