 Nyora kupfuurira kweiyi ndima - Charles akagadzwa samambo muRoma pana 5 January 1266. Akaparadza uto raManfreduye vakagara muRegno pasina kumira-mira. Kukunda kwake muzukuru muduku waManfred, Conradin, paHondo yeTagliacozzo muna 1268 kwakasimbisa kutonga kwake. Muna 1270 akatora chikamu muEighth Crusade yakarongwa naLouis IX, uye akamanikidza Hafsid Caliph weTunis kuti amubhadhare mutero wegore negore. Kukunda kwaCharles kwakamuita kuti ave mutungamiriri asingapikiswi pakati pevatsigiri vePapa vokuItaly vaizivikanwa sevaGuelphs, asi zvaaiita pakusarudzwa kwapapa uye kuvapo kwake kwakasimba muchiuto muItaly zvakavhiringidza vanapapa. Vakaedza kutungamira vavariro dzake kune dzimwe nzvimbo uye vakamubatsira mukuwana zvirevo kuAkaya, Jerusarema neArles kuburikidza nezvibvumirano. Muna 1281 Papa Martin IV akapa Charles mvumo yokutanga hondo yokurwisana noUmambo hweByzantium. Ngarava dzaCharles dzakanga dzichiungana paMessina, dzakagadzirira kutanga hondo apo mhirizhonga inozivikanwa seSicilian Vespers yakatanga musi wa30March 1282 iyo yakaguma nokutonga kwaCharles pachitsuwa cheSicily. Akakwanisa kudzivirira nharaunda dzomunyika yacho kana kuti Umambo hweNaples achitsigirwa neFrance neHoly See. Charles akafa achigadzirira kupinda muSicily. 