 Hepburn akaroora muna 1511 murume wokutanga pavarume vake vana Agnes akafa muna February 1557, mwanasikana asiri wapamutemo waJames Stewart, 1st Earl weBuchan naMargaret Murray. Uyu Agnes Stewart akapiwa Tsamba dzeMutemo, dzakasimbiswa naMambokadzi Mary weGuise, musi wa31 October 1552, pasi peChisimbiso Chikuru cheScotland. Hepburn naAgnes vaiva nomwana mumwe: Patrick. Hepburn akaurayiwa paHondo yeFlodden, kwaaitungamirira varwi vokuScotland. 