 Nyorai kuenderera mberi kweiyi ndima - Pasi peAchaemenids, Iranization yeAsia Minor yakanga yakakosha, uye huvepo hukuru hweIran hwakanga hwagadzwa kumadokero kweAsia Minor, Pontus neCappadocia. Ariarathes akanga ave ari mutongi weKapadhokiya kwemakore 19 uye akanga ari mutsigiri akavimbika wamadzimambo eAchaemenid. Nokuda kweropa, akanga ane ukama neimba yaitonga yaAchaemenid Koreshi naDhariusi Vane Manomwe pamwe chete navamwe vatongi. Alexander weMakedhoniya paakapinda muKapadhokiya sechikamu chokukunda kwake Umambo hwePezhiya, akagadza magavhuna maviri enguva pfupi. Nokuda kwavaIran muAsia Minor, sezvingabvira kwose kwose, kuwa kwavaAchaemenid kwakareva nhamo. Nokukunda kwaAlexander uye kubuda kwamadzimambo akatsiva echiHellenistic, vaIran muCaria uye zvichida muAsia Minor yose yokumadokero pakupedzisira vakavamba kuzvichinjira vamene kumugariro unochinja. Kuvapo kweIran kumadokero kwerwizi rweHalys nokudaro kwakavamba kunyangarika zvishoma nezvishoma. Zvisinei, kumabvazuva kweRwizi rweHalys, zvinhu zvakafamba zvakasiyana. VaKapadhokiya vakanga varatidza kushora vaMakedhoniya vaipinda nechisimba kubvira pakutanga. Pashure pokudzivirira HalicarnassusMaererano nebhuku rinonzi The Histories, vaKapadhokiya vakapinda muhondo yeGaugamela 331 BCE vachirwisa Alexander, uye kunyange pashure pehondo, vakasimuka kumashure kwake. 