 Pierce akarambidza mari yokuvandudza zvinhu mukati, akadaidzira kuti pave nomutero wakaderera, uye akasimbisa zvakasimba Mutemo weVaranda Vanotiza wa1850. Ichipesvedzerwa neboka reYoung America, hurumende yaPierce yakapedzisa kutenga nyika kwaGadsden kubva kuMexico, yakatarisana neBritish Empire muCentral America, uye yakatungamira kuedza kwakakundikana kuwana Cuba kubva kuSpanish Empire. Kutonga kwaPierce kwakashorwa zvikuru pashure pokunge vamwe vamiriri vake vakawanda vabudisa Ostend Manifesto, iyo yaidaidzira kubatanidzwa kweCuba, nesimba kana zvichidiwa. Kuzivikanwa kwake muNorthern free states kwakaderera zvikuru pashure pokunge atsigira 1854 KansasNebraska Act, iyo yakabvisa Missouri Compromise. Kuparurwa kwechiito chacho kwakatungamirira zvakananga kukakavadzana kwenguva refu uye kwechisimbapamusoro pokupararira kwouranda muUnited States yokuMadokero. 