 Nyorai mberi kweiyi ndima - Iye nemhuri yake vakamanikidzwa kutiza Florence musi wa27 Kubvumbi 1859, nekutanga kweshanduko yakafuridzirwa nekutanga kwehondo neFrance neSardinia-Piedmont vachipesana neAustriasorutivi rwekubatanidzwa kweItaly. Mhuri yacho yakatizira kuAustria. Pashure pokuguma kwehondo, Leopold II akasiya chigaro pana 21 July uye Ferdinand akamutsiva saGreat Duke. Ferdinand akaratidza kuti akanga asingakwanisi kudzokera kuFlorence kunotora chigaro chake choumambo, uye musangano weTuscan National Assembly wakasarudzwa wakamutora pamutemo mwedzi mumwe chete gare gare, musi wa16 August. Ferdinand akanga achiri netariro yokudzorera chigaro chake choumambo, sezvo vose vari vaviri France neAustria vakanga vavimbisa kuziva maruramiro ake pacho muChibvumirano cheVillafranca. Zvisinei, hapana simba rakanga richida kutora matanho ekuunza kudzorerwa kwake; Sardinia yaizobatanidza Tuscany musi wa 22 Kurume 1860, uye neAustria ichiziva Humambo hutsva hweItaly mushure meHondo yechitatu yeRusununguko muna 1866, tariro yaFerdinand yekudzorera chigaro yakapera. 