 Nyorera kupfuurira kweiyi ndima - Muhupenyu hwake hwese, Messi ave achibatanidzwa mukuyedza kubatsira vana vanotambura, kuzvipira kunobva muchidimbu kumatambudziko ekurapa aakatarisana nawo paudiki hwake. Kubva 2004, ave achipa nguva yake nemari kuUnited Nations Childrens Fund UNICEF, sangano iro Barcelona rinewo hukama hwakasimba. Messi akashanda semumiriri weUNICEF kubva paakagadzwa munaKurume 2010, achipedzisa basa rake rekutanga musangano mwedzi mina gare gare paakaenda kuHaiti kunopa ruzhinji ruzivo nezve dambudziko revana venyika iyi zvichitevera kudengenyeka kwenyika kuchangobva kuitika.. Kubvira ipapo ave achibatanidzwa mumishandirapamwe yeUNICEF yakanangana nekudzivirira HIV, dzidzo, uye kubatanidzwa munzanga kwevana vakaremara. Kupemberera zuva rokuberekwa rokutanga romwanakomana wake, muna November 2013, Messi naThiago vakanga vari chikamu chemushandirapamwe wokushambadzira kuti vawedzere kuziva nezvekufa kwevana pakati pevana vanotambura. 