 Wilson akatsvaka ukama hwapedyo neLatin America, uye aitarisira kugadzira sangano rePan-America rokugadzirisa gakava renyika dzakawanda. Iyewo akakurukura chibvumirano neColombia icho chaizodai chakabhadhara nyika iyoyo muripo nokuda kwebasa reU.S. mukuparadzana kwePanama, asi Seneti yakakunda chibvumirano ichi. Zvisinei, Wilson aigara achipindira munyaya dzeLatin America, achitaura muna 1913 kuti: Ndichadzidzisa nyika dzeSouth America kuti dzisarudze vanhu vakanaka. Dominican Republic yakanga yave iri de facto nzvimbo yaidzivirirwa neAmerica kubvira pakutonga kwaVaRoosevelt, asi yakatambura nokusava nechokwadi. Muna 1916, Wilson akatumira mauto kuzotora chitsuwa chacho, uye mauto eU.S. aizoramba aripo kusvikira muna 1924. Muna 1915, U.S. yakapinda muHaiti pashure pokunge kumukira kwakanga kwaparadza hurumende yeHaiti, kutanga basa raizogara kusvikira muna 1919. Wilson akabvumirawo kupindira kwemauto muCuba, Panama, neHonduras. Chibvumirano chaBryan-Chamorro cha1914 chakaita kuti Nicaragua ive imwe nyika inodzivirira, uye U.S. yakaisa varwiikoko mukati mokutonga kwaWilson. 