 Pakatanga Hondo Yenyika I muna 1914, U.S. yakazivisa kuti yakanga isingatori rutivi sezvo Wilson akaedza kutaurirana rugare pakati peAllied neCentral Powers. Akakundwa zvishoma musarudzo dzomutungamiri wenyika yeUnited States dza1916, achizvirumbidza pamusoro pokuti akachengeta sei rudzi rwacho kunze kwehondo muEurope neMexico. Muna April 1917, Wilson akakumbira Kongiresi kuti imurwise Germany pamusana pemitemo yayo yokurwisa ngarava dzepasi pemvura dzisina kudzivirirwa dzainyudza ngarava dzezvokutengeserana dzeAmerica. Wilson nomuzvarirwo aitungamirira kuunganidzwa kwevanhu munguva yehondo uye akasiya zvinhu zvechiuto mumaoko emauto. Panzvimbo pezvo akaisa pfungwa dzake pakukurukurirana, achibudisa Mashoko Gumi Nemana ayo maAllies neGermany akagamuchira sehwaro hworugare pashure pehondo. Akanga achida kuti sarudzo dzomugore ra1918 dzive referendamu inotsigira mitemo yake, asi panzvimbo pezvo maRepublican akatora kudzora Congress. Pashure pokukunda kweAlliedMuna November 1918, Wilson akaenda kuParis uko iye nevatungamiriri veBritain neFrance vakatonga Musangano woRugare weParis. Wilson akabudirira kutsigira kuumbwa kwesangano renyika dzakawanda, Sangano Renyika Dzakabatana. Yakasanganiswa muChibvumirano cheVersailles chaakasaina. Wilson akanga aramba kuunza chero mutungamiriri weRepublican munhaurirano dzeParis, uye kumusha akaramba chibvumirano cheRepublican icho chaizobvumira Seneti kubvumidza Chibvumirano cheVersailles uye kubatana neSangano. Wilson akanga ane chinangwa chokutsvaka nguva yechitatu muhofisi asi akatambura sitiroko yakakomba muna October 1919 iyo yakamusiya asingakwanisi. Mudzimai wake nachiremba wake vakadzora Wilson, uye hapana zvisarudzo zvinokosha zvakaitwa. Munguvayi, mitemo yake yakaparadzanisa maGerman nemaIrish maDemocrat uye maRepublican akakunda zvine mutsindo musarudzo yemutungamiri wenyika ya1920. Nyanzvi dzave dzichiwanzoronga Wilson muchikamu chepamusoro chevatungamiri veU.S., kunyange zvazvo ave achishoropodzwa nokuda kwokutsigira kuparadzana kwemarudzi. Rusununguko rwake zvisinei runorarama sechinhu chikuru muhurongwa hwekunze kweAmerica, uye chiono chake chokusarudza kwedzinza chakateerera munyika yose. 