 Nyorai kupfuurira kweiyi ndima - Pamberi pa2005, Guthrie akabata chinyorwa chokupedza kwakanakisisa munhangemutange. Gore iroro, Danica Patrick, akaita kutanga kwake muIndianapolis, achiva wechina. Akatungamirira kumativi 19, akapedza ari panzvimbo yechina, uye akatumidzwa kuti Rookie of the Year. Muna 2008, ndiye akava mukadzi wokutanga kuhwina mujaho weIndyCar paakakunda paTwin Ring Motegi muJapan. Akavandudza rekodhi yake muna 2009, achipedza wechitatu, uye akatungamirawo kumhanya muCentennial Race muna 2011. Kubva muna 2017, ndiye zvakare mutyairi wechikadzi wekutanga kutungamira mapoinzi muIndianapolis 500, Daytona 500, uye Coca-Cola 600. 