 Nyorai kupfuurira kweiyi ndima - Pana January 29, 1863, Grant akafungidzira kutonga kwose. Pakupedzisira, akaedza kufambisira mberi uto rake nomunzvimbo ine mvura kuti akunde pfuti dzaVicksburg. Zano rokurwisa Vicksburg richibva kurwizi rwacho raiva nengozi zvikuru nokuti pavaizoyambuka Rwizi rweMississippi, uto rake raisazokwanisa kusvika kumigero yaro yakawanda yokupa zvokudya. Musi waApril 16, Grant akarayira Admiral David Dixon Porters gunboats kumaodzanyemba pasi pemoto kubva kuVicksburg mabhatiri kuti asangane nemauto aive afamba kumaodzanyemba kumadokero kwerwizi. Grant akarayira hondo dzokutsausa vanhu, achivhiringidza Pemberton uye achibvumira uto raGrant kuti riende kumabvazuva kuyambuka rwizi rweMississippi, richitumira mauto kuBruinsburg. Mauto aGrant akatora Jackson, guta guru renyika yacho. Achienda kumadokero, Grant akakunda uto raPemberton paHondo yeChampion Hillpana May 16, achivamanikidza kudzokera kuVicksburg. Pashure pokunge varume vaGrant varwisa nhare kaviri, vachitambura kurasikirwa kukuru, vakagadzirira kukomba kwakatora vhiki nomwe. Mukati menguva dzerunyararo dzokutsvaka rutsigiro, Grant aizonwa pane dzimwe nguva. Rwisano yomunhu oga pakati paMcClernand naGrant yakapfuurira kusvikira Grant amubvisa mumutungamiri paakapesana naGrant nokubudisa murairo pasina mvumo. Pemberton akazviisa pasi paVicksburg kuna Grant musi waJuly 4, 1863. 