 Ramba uchinyora ndima iyi - Kutonga kwaPapa kwaClement VII kwakanga kwakazara nenyonganyonga kwakakurumidza kutevedzana kwematambudziko ezvematongerwe enyika - akawanda akanga ava nenguva achigadziriswa - ayo akapedzisira ava kupambwa kweRomanemauto aMambo Mutsvene weRoma Charles V muna 1527 uye kusimuka kwaSalviati, Altoviti naStrozzi semabhangi anotungamirira eCuria yeRoma. Kubvira panguva yakasarudzwa Clement kuti ave papa muna 1523 kusvikira kupambwa kweRoma, Florence yaitongwa naIppolito de Medici muduku akazova mufundisi uye mutevedzeri womukuru mukuru weChechi Tsvene yeRoma, Alessandro de Medici akazova mutongi weFlorence, uye vachengeti vavo. Muna 1530, pashure pokuzvibatanidza amene naCharles V, Pope Clement VII akabudirira mukuita kuti mwanasikana waCharles V, Margeret weAustria, aroorwe nomuzukuru wake asiri wapamutemo anofungidzirwa kuva mwanakomana wake Alessandro de Medici. Clement akanyengetedzawo Charles V kuti agadze Alessandro saDuke weFlorence. Nokudaro kwakatanga kutonga kwemadzimambo eMedici muFlorence, uko kwakatora mazana maviri emakore. 