 Osei-Kwaku aive nhengo yeNew Patriotic Party, akashanda senhengo yeparamende yedunhu reAsokwa West kubva musi wa7 Ndira 1997 kusvika musi wa6 Ndira 2005. Panguva yesarudzo huru dza1996 muGhana, akawana mavhoti 42,734 ayo akaenzana ne52.7 yemavhoti akazara, uye panguva yesarudzo huru dza2000 muGhana, akawana mavhoti 48,738 ayo akaenzana ne74.5 yemavhoti akazara. Munguva yekutonga kwaKufuor, akagadzwa mutevedzeri wegurukota rezveMutungamiri uye gare gare Gurukota reVechidiki neMitambo. Panguva yaaive muhofisi seGurukota reVechidiki neMitambo, akabatsira kutanga kukwikwidza kweGhana kuitisa CAN 2008mutambo. Akabatsirawo mukugadziridza nhandare huru dzeGhana, Accra Sports Stadium neKumasi Sports Stadium yava kunzi Baba Yara Stadium. 