 Nyora kuenderera mberi kweiyi ndima - Mumwaka wa2015-16, Biglia akagadzwa semutungamiriri mutsva weLazio zvichitevera kuenda kwaStefano Mauri akazodzokera kukirabhu nguva pfupi yapfuura uye akatungamira mutambo wake wekutanga muSupercoppa Italianamutambo, uchirasikirwa ne2-0 kuJuventus. Mushure memutambo, Bigila akawanazve kutanga kwakanaka mumutambo wekuvhura mwaka uye akarova mukukunda 21 pamusoro peBologna. Mushure mekutambura kukuvara kwemhuru mumutambo wekupedzisira, akaratidza kudzoka kwake kubva mukukuvara nekugadzira chinangwa mukukunda 20 pamusoro peHellas Verona musi wa27 Gunyana 2015. Akabva arova mu 3-2 kukunda Saint-Étienne UEFA Europa League. Mushure mekupora kubva mukukuvara kwehamstring, Biglia akarova zvakare musi wa28 Gumiguru 2015 mukurasikirwa ne2 × 1 kurwisa Atalanta. Pasinei nokuvharirwa nekuda kwekuregererwa uye kukuvara, yakanga isati yasvika musi wa 6 Kurume 2016 paakarova chinangwa chake chechishanu chemwaka, mukukwikwidza 11 kurwisa Torino. Zvisinei, Biglia akatumirwa kunze musi wa 8 Chivabvu 2016 mushure mekukanganisa kwechipiri kunyorwa mukukunda 31 pamusoro peCarpi. 