 Ramba uchinyora ndima iyi - Zvirwere zvakaunzwa kuAmerica nevavakundi zvakava nomugumisiro wakakura pavanhu vomunzvimbomo. Sezvo vaSpanish vakanga vakabatikana nokukunda Mexico, hosha idzi dzakavatangira kubva muna 1519 zvichienda mberi. Denda remamota rakapararira muGuatemala muna 15201521, uye zvinokwanisika kuti rakapararirawo munharaunda yose yePipil yeEl Salvador. Pakazosvika vanhu vokuSpain munharaunda yacho muna 1524, zvinonzi vanhu vokuEl Salvador vanosvika 50 muzana vakanga vafa nechirwere chitsva ichi, chavakanga vasina simba rokurwisa. Zvingangodaro kuti chirwere chakanga chaderedza simba revaPipil zvikuru panguva yavakaisa mauto makuru kuti arwise vaSpanish paAcajutla neTacuzcalco. Mamwe mafungu ezvirwere zvehosha akapararira muMesoamerica muna 15451548, uye zvakare muna 15761581, achideredza vagari vemo kusvika pa10 chete yematanho avo epamberi pekusangana, zvichiita kuti kubudirira kurwisa varwi vekuEurope kunyanye kuoma. Zvirwere zvaipisisa pazvirwere zvitsva zvakaunzwa zvaiva chirwere chetsvo, marariya, chibhokisi, typhus, uye yellow fever. Kuunzwa kwadzo kwakanga kune ngwavaira muAmerica; kunofungidzirwa kuti 90 yavagari vemo vakanga vaparadzwa nehosha mukati mezana rokutanga ramakore rokusangana kweEurope. 