 Nyora kupfuurira kweiyi ndima - Byrne akanga achishingaira mumasangano anoverengeka omunzanga, kubatanidza YMCA neElks. Pashure pokupinda Democratic National Convention ya1896uye kunzwa William Jennings Bryan achitaura, Byrne akatanga kufarira kutaura kwoupenyu hwose. Mukuwedzera kukudziridza unyanzvi hwake hwokutaura kupfurikidza nefundo nokurovedza, Byrne akarayiridza kosi yokutaura pachena nokuda kweYMCA yomunharaunda yeAlbany. Akadzidzisawo kutaura pamberi pevanhu paAlbany Law School. Byrne aitaura kakawanda pazviitiko zvevoruzhinji uye akawana mukurumbira munyika yose somutauri akamirira masangano aya nemamwewo. Muna 1922 na1924, Byrne akasarudza Al Smith kuti ave gavhuna pamusangano weDemocratic. Muna 1938, akakumbirwa kuti asarudze Herbert H. Lehman kuti asarudzwezve kuva gavhuna. 