 Serrano akaberekwa musi wa 26 Kubvumbi 1945 muGuatemala City semwanakomana waJorge Adán Serrano naRosa Elías, aive wedzinza reLebanese. Pashure pokuenda kuchikoro muSwitzerland akapedza kudzidza muinjiniya wezvirimwa paUniversity of San Carlos, uye ipapo akapinda Stanford University muCalifornia, U.S., uko akadzidza kukura kwezvemari ndokuwana dhigirii rechiremba mune dzidzo nesayenzi. Ipapo akadzokera kuGuatemala kuti ave mushandi wehurumende. Muna 1976 akabatana nemachechi akasiyana-siyana echiPurotesitendi okuAmerica kubatsira vanhu kuti vapore pakadengenyeka nyika kwakaparadzarakanga raparadza nyika. Ipapo akabudisa gwaro rinorondedzera mamiriro ezvinhu anosiririsa ayo vanhu vomunzvimbomo vaigara pasi pawo, izvo zvakaguma nokugamuchira kwake tyisidziro. Akaenda kunhapwa muUS, achingodzoka muna 1982, kunoshanda muhurumende yemumwe muevhangeri General Efraín Ríos Montt seMutevedzeri weMutungamiri weAdvisory Board kuhurumende. 