 Vagari vePennsylvania kazhinji vakatsigira mhirizhonga yakajairika kumakoroni gumi nematatu mushure mekunge Chiziviso cha1763 neStamp Act zvapfuudzwa, uye Pennsylvania yakatumira nhume kuStamp Act Congress muna 1765 Philadelphia yakabata yekutanga neyechipiri Continental Congresses, yekupedzisira iyo yakaguma nekugamuchirwa kweChirevo cheRusununguko muIndependence Hall muna 1776. Pennsylvania yaiva nzvimbo yehondo dzinoverengeka nemabasa ehondo munguva yeAmerican Revolution, kusanganisira kuyambuka kwaGeorge Washington kweRwizi rweDelaware, Hondo yeBrandywine, uye Hondo yeGermantown. Munguva yokurwisa kwePhiladelphia, uto revapanduki raGeorge Washington rakapedza nguva yechando ya177778 paVall Forge, Pennsylvania. Muna 1781, Zvinyorwa zveConfederation zvakanyorwa uye zvakagamuchirwa muYork, Pennsylvania, uye Philadelphia yakaramba ichishanda seguta guru renyika ichangotanga kusvika paPennsylvania Mutiny ya1783. VaPennsylvanians vakakurumbira vakatsigira Revolution vanosanganisira Benjamin Franklin, John Dickinson, Robert Morris, Anthony Wayne, Samuel Van Leer, James Wilson, naThomas Mifflin. Zvisinei, Pennsylvania yaivawo musha wevakavimbika vakawanda, kusanganisira Joseph Galloway, William Allen, uye Doan Outlaws. 