 Nguva yekuwedzera kukuru kweArmenia yakaitika naTigranes II Mukuru; 9555 BC uyo akazviita nyika ine simba kwazvo kumabvazuva kweRoma, sezvo humambo hwakasiyana-siyana hwekuMadokero kweAnatolia hwakanyudzwa munzvimbo yeRoma yekupesvedzera. Akasimbisa simba rake mukati meArmenia, achitorazve Sophene mushure mekubvisa mambo Artanes. Iyi yakanga iri nguva yeHondo dzeMithridatic 8863 BC pakati pePonto, muvakidzani wake wokuchamhembe kwakadziva kumadokero, neRoma. Akaumba mubatanidzwa naMithridates VI wePonto 12063 BC, achiroora mwanasikana wake Cleopatra. Nokutora Siriya, Fenikiya neKirikiya, akabudirira kuderedza umambo hwaSeleucus kuti huve nyika duku. Kuita zvechisimba kwaPonto neArmenia kwakangoita kuti vapindane neRoma yaienda kumabvazuva, uye vaArmenia vakakundwa muhondo yeTigranocerta69 P.N.V.. Pakazosvika 67 BC Pompey akanga asvika kumabvazuva kweAnatolia nechinangwa chaicho chokupwanya nyika mbiri idzi. Tigranes akazvipira muna 66 BC, uye Armenia yakava nyika yevatengi. Nhengo dzakasara dzedzinza, idzo pakupedzisira dzakapera muna 1 BC, dzaiva noukama husina kugadzikana neRoma kumadokero uye Parthia kumabvazuva kubva uko. Roma yaiona Armenia senyika inodzivirira Parthia, yaida kupindira kakawanda nevaRoma. 