 Nyora kuenderera mberi kweiyi ndima - Anofungidzirwa semumwe wevashumiri vakanakisa kuti vatambe paATP Tour, Isner akawana basa rake repamusoro-soro muJuly 2018 nekuda kwekorona yake yekutanga yeMasters 1000 pa2018 Miami Open uye semifinals kuonekwa pa2018 Wimbledon Championships. Akasvikawo kaviri kumaquarterfinals kuUS Open muna 2011 na2018, iyo yekupedzisira yakamubatsira kuti akwanise kuita yake yekutanga ATP Finals kuoneka gare gare gore iro. Iye zvino ndiye wechipiri-ane ma aces akawanda munhoroondo yeATP Tour, achishanda pamusoro pe13 000 aces. Pa2010 Wimbledon Championships, akatamba mutambo wetennis wakarebesa munhoroondo, vachikunda Nicolas Mahut mumaawa gumi nerimwe nemaminitsi mashanu, vakatamba kwemazuva matatu. Isner parizvino akabata rekodhi yekurova yakakurumidza yepamutemo yeATP yakambobvira uye yechitatu-yakakurumidza pakurekodha mu tennis panguva yake yekutanga-kutenderera 2016 Davis Cup mutambo. Musi wa17 Nyamavhuvhu 2021 ku2021 Western Southern Open, akazova mutambi wechipiri chete pasi rose kuti asvike 13,000 aces pane akawanda aces mune runyorwa rwebasa kwete kusanganisira Davis Cup, achibatana naIvo Karlovic. 