 Nyorai kuenderera mberi kweiyi ndima - Catherine akaberekerwa kuDucal Palace yeVila Viçosa, semwanasikana wechipiri mupenyu waJohn, 8th Duke weBraganza nemukadzi wake, Luisa de Guzmán. Pashure peHondo Yokudzorera yePortugal, baba vake vakava Mambo John IV wePortugal, musi wa 1 December 1640. Nechinzvimbo chitsva chababa vake semumwe wemadzimambo akakosha eEurope, Portugal ipapo yaive nehumambo hwakapararira hwekoloni, Catherine akazova sarudzo yekutanga yemukadzi wehumambo hweEurope, uye akakurudzirwa semwenga waJohn weAustria, François de Vendôme, duc de Beaufort, Louis XIV naCharles II. Kurangarirwa kwesarudzo yekupedzisira kwakakonzerwa nekumuona semugwagwa unobatsira wekubvumirana mubatanidzwa pakati pePortugal neEngland, mushure meChibvumirano chePyrenees muna 1659 umo Portugal yakasiiwa neFrance. Pasinei zvapo nokurwisana kwakanga kuchiripo pakati penyika yake neSpain, Catherine akafarikanya uduku hunofadza, hunogutsa muLisbon yake yaanoda. 