 Ramba uchiverenga ndima iyi - The Giants vakanyora Cain kubva kuchikoro chesekondari muna 2002, uye akaita MLB yake yekutanga pazera remakore 20 muna 2002, achiva mutambi wechidiki muNational League NL gore iroro. Muna 2009, Kaini akatumidzwa zita rake rekutanga basa reAll-Star Game uye akahwina mubairo weWillie Mac. Munguva ye2010 MLB postseason, haana kubvumidza kuhwina mumutambo chero upi zvawo mumitambo mitatu yeplayoff yaakatamba maGiants pavakakunda World Series yavo yekutangakubvira muna 1954. Muna 2012, Kaini akasaina chibvumirano chekuwedzera icho, panguva iyoyo, chakamupa chibvumirano chinobhadhara zvakanyanya chakambogamuchirwa nemuputi wekurudyi munhoroondo yeligi huru. Kaini akakanda mutambo wakakwana wechi22 munhoroondo yeligi huru musi wa13 Chikumi 2012. Akanga aine 165 rekodhi panguva yegore ra2012 nguva dzose, achipedzisa wechitanhatu muNL Cy Young Award kuvhota. Munguva yeGiants playoff run iyo yakatungamira kukunda kwavo mu2012 World Series, timu yakakunda yega yega-series-clinching playoff mutambo uyo Kaini akatanga. Cain akapedza basa rake rokukanda muna 2017. 