 Panguva imwecheteyo, akasarudzwa seCaptain general weGungwa, sechikamu cheiyo anti-Ottoman crusade yakarongedzwa naMambo Ladislaus III wePoland neHungary naJohn Hunyadi; zvisinei, maVenetians haana kuita chero chiitiko chakakomba chegore, uye musi wa11 Mbudzi Loredan pachinzvimbo akagadzwa semumwe we savii alle acque vakuru vakuru vane basa rekutarisa nzira dzemvura dzeVenetian Lagoon. Musi wa 25 April 1444, Loredan akagadzwa kuva mukuru wemauto eVenetian nePapal ayo aizoenda kunotora rutivi muhondo dzemakwikwi. Mirayiridzo yake, yakagamuchirwa musi wa 17 Chikumi, yaive yekudzivisa Sultan weOttoman, Murad II, kubva pakuyambuka neuto rake kupinda muAnatolia uye achienda kunorwisa mutongi weKaramanid Ibrahim, uyo aive akabatana neChristian League. Muchiitiko ichocho, Loredan akasvika kuTurkish Straits kunonoka kuti amise Murad. Sezvo kurwisa kwechiKristu muBalkan kwakange kwanonoka, musi wa9 Gunyana akagamuchira rairo kubva kuVenice kuti arege kuita zviito zvekurwisa uye kutaurirana zvakavanzika pachena naSultan, uyo panguva iyi akakunda maKaramanids. Zvisinei, uto revaCrusader parakatanga kurwisa, akapomerwa mhosva yokudzivisa uto reOttoman kudzokera kuEurope. Loredan akavhara Dardanelles, asi Murad akasarudza kuyambuka Bosporus kuchamhembe kweConstantinople. Somuuyo, pana November 11, paHondo yeVarnaMuna 70 C.E., vaOttoman vakaparadza mauto evaCrusader. Apo Venice yaikurukura rugare naSultan, Loredan akapedza gore rakatevera achifamba nechikepe chake muAegean, kuti adzivirire zvinhu zveVenice nevatsigiri kubva kuOttoman kutsiva. 