 Nyora kuenderera mberi kweiyi ndima - Akatanga basa rake mukirabhu yekumusha kwake Marsonia kubva kwaakaenda kunzvimbo mbiri dzebhora reguta guru reCroatia, akatanga kujoina NK Zagreb uye ndokuzosaina neDinamo Zagreb muna 2007, kwaaive Prva HNL yepamusoro zvibodzwa mumwaka wa2008-09. Kuwana kwake zvibodzwa kwakamupa kutamira kuVfL Wolfsburg muna 2010. Mushure mekuratidzira kunoshamisa kuUEFA Euro 2012, uko kwaaive mubatanidzwa wepamusoro zvibodzwa, akasainwa neBayern Munich. Mumwaka wake wekutanga nekirabhu akahwina mikombe mitatu; iyo Bundesliga, DFB-Pokal, uye iyo Champions League, uku achivewo wekutanga weCroatia kurova muChampions League yekupedzisira. Mushure mekukunda kaviri mumwaka unotevera, akasiya Bayern kuenda kuAtlético Madrid muna 2014, uye mwaka mumwe gare gare akasainwa naJuventus kwemamiriyoni gumi nemapfumbamwe emadhora, kwaakakunda kaviri mumwaka wake wekutanga matatu, achiteverwa neimwe zita religi gore rinotevera. Mumakwikwi ekupedzisira eChampions League ya2017, akarova chibodzwa chake chechipiri cheChampions League, kurova pamusoro pemusoro kwakapfuura muchengeti wemukombe kwakamupa mubairo weEFA Goal of the Season. Mandžukić akabva kuJuventus muna Zvita 2019 kuenda kuQatari divi Al-Duhail; zvisinei, mushure mekurwira kuchinjika, akagumisa chibvumirano chake ndokudzokera kuItari muna Ndira 2021, achisaina neMilan. 