 Nyorai kupfuurira kweiyi ndima - VaHospitaliers vakapfuurira nezviito zvavo mukurwisana navaMuslim uye zvikurukuru vapambi veBarbary. Kunyange zvazvo vakanga vane ngarava shomanene bedzi vakakurumidza kukwezva hasha dzavaOttoman, avo vakanga vasingafari kuona hurongwa hwacho huchiparadzaniswa. Muna July 1551, mauto eOttoman akaedza kutora Fort Saint Angelo uye gare gare Mdina asi vakaona kuti vakanga vashoma uye vakapinda muGozomazuva anoverengeka gare gare. Vakaenda kuTripoli ndokutora guta racho muna August. Pashure pokurwiswa uku, Order yakaedza kuzadzazve Gozo uye kusimbisa masvingo eGreat Harbour. Nhare dzinoverengeka kusanganisira Saint Elmo naSaint Michael dzakavakwa, uye guta reSenglea rakatanga kukura rakakomberedza nhare yekupedzisira. 