 Nyorai kuenderera mberi kweiyi ndima - Mushure mekunge Sangano reCognac rakundikana, Francis akapedzisa mubatanidzwa wepachivande neLandgrave weHesse musi wa27 Ndira 1534. Ikoku kwakanga kwakanangidzirwa kuna Charles V nechikonzero chokubetsera Duke weWürttemberg kuwanazve chigaro chake chetsika, icho Charles akanga amubvisa muna 1519. Francis akawanawo betsero yoUmambo hweOttoman uye pashure porufu rwaFrancesco II Sforza, mutongi weMilan, akadzorera makwikwi muItaly muHondo yeItaly ya15361538. Iyi nhambo yokurwa, iyo yakanga isina mugumisiro muduku, yakaguma neKupedza Hondo kweNice. Zvisinei, chibvumirano chacho chakakundikana, izvo zvakatungamirira kuedza kwokupedzisira kwaFrancis kuItaly muHondo yeItaly ya15421546. Panguva ino Francis akakwanisa kudzivisa mauto aCharles V naHenry VIII. Charles V akamanikidzwa kusaina Chibvumirano cheCrépy nemhaka yezvinetso zvake zvemari nokurwisana neSchmalkaldic League. 