 Nyora kupfuurira kweiyi ndima - Cleopatra akaenda kuRoma samambokadzi mutengi muna 46 na 44 BC, achigara muimba yake. Pashure pokuurayiwa kwaKesarimuna 44 BC Cleopatra akaedza kuita kuti Caesarion atumidzwe somudyi wenhaka yake. Muzukuru waKesari Octavian anozivikanwa saAugustus na 27 BC, apo akava mambo wokutanga weRoma akavhiringidza ikoku. Cleopatra ipapo akaita kuti munununa wake Ptolemy XIV aurawe ndokusimudzira mwanakomana wake Caesarion somutongi pamwe chete naye. Muhondo yevagari vemo yeVasununguri ya 4342 BC, Cleopatra akatsigira Second Triumvirate yeRoma yakaumbwa naOctavian, Mark Antony, naMarcus Aemilius Lepidus. Akaumba ukama hwomunhu oga naMark Antony uyo pakupedzisira aizobereka vana vatatu: mapatya Alexander Helios naCleopatra Selene II, naPtolemy Philadelphus. Antony akashandisa simba rake somutongi kuti auraye Arsinoe IV pakukumbira kwaCleopatra. Akawedzera kuvimba naCleopatra nokuda kwezvose zviri zviviri mari uye rubatsiro rwemauto panguva yokupinda kwake muUmambo hweParthia noUmambo hweArmenia. Kunyange zvazvo kudenha kwake Parthia kwakanga kusina kubudirira, akakwanisa kutora Armenia. Akaunza Mambo Artavasdes II kuAlexandria muna 34 BC semusungwa mukukunda kwake kwokunyepedzera kweRoma kwakagamuchirwa naCleopatra. Izvi zvakateverwa neZvipo zveAlexandria, umo vana vaCleopatra naAntony vakagamuchira nharaunda dzakasiyana pasi pesimba raAntony. Cleopatra akanzi Mambokadzi waMadzimambo uye Caesarion Mambo waMadzimambo. Chiitiko ichi, pamwe chete nokuroorwa kwaAntony naCleopatra uye kurambana kwaOctavia Minor, hanzvadzi yaOctavian, zvakaratidzira chinjo yakatungamirira kuHondo Yokupedzisira yeRepublic yeRoma. 