 Nyorai kuenderera mberi kweiyi ndima - Munguva yebasa rake, Serena akatambira makirabhu akati wandei eItaly: Montebelluna, Inter, Como, Bari, AC Milan, Juventus neTorino. Akazvarwa muMontebelluna, mudunhu reTreviso, akapedza hudiki hwake achitamba nechikwata chevechidiki cheguta rake. Mushure mekuita nyanzvi yake yekutanga nechikwata chevakuru cheMontebelluna muSerie D muna 1977, uye akarova zvibodzwa zvipfumbamwe mumitambo makumi maviri nemapfumbamwe mumwaka wake wekutanga, Serena akatanga kujoina Inter mwaka unoteveramuna 1978; akaita Serie A yake kutanga gare gare gore iroro, musi wa19 Mbudzi, mune 4 0 kumba kukunda Lazio, achimaka chiitiko nechinangwa chake chekutanga muSerie A, uye zvakare achiita imwe ligi kuoneka gare gare mwaka iwoyo. Kunyange zvazvo iye pakutanga akahwina 198182 Coppa Italia panguva yake yokutanga spell pamwe kirabhu, iye ainyanya akashanda somunhu negadziriro yeparutivi, uye akanga pakutanga akweretwa kune dzimwe mativi akawanda Italian: akapedza mwaka pachikwereti pamwe Como, Bari, muchinjikwa-guta vakwikwidzi Milan, uye Torino. Akaitawo kubudirira kwemwaka miviri nemukwikwidzi Juventus pakati pa1985 na1987, achihwina zvibodzwa makumi maviri nezviviri muSerie A mumitambo makumi mashanu neshanu, pamwe nekuhwina 1985 Intercontinental Cup uye 1985-86 Serie A zita; Pakazara, akahwina zvibodzwa makumi matatu nezvitanhatu mumakwikwi ese kudivi reTurin mumitambo makumi manomwe nenomwe. Serena akafarikanya kubudirira kukuru pashure pokudzokera kuInter nokuda kwechiratidzo chake chechipiri muna 1987. Mwaka wake wakanakisa nechikwata cheMilan wakauya panguva yemushandirapamwe wa1988-89 pasi pemaneja Giovanni Trapattoni, paakakunda Scudetto neInter aine rekodhi yemapoinzi makumi mashanu nemasere kirabhu yegumi nematatu Serie A zita rakazara, uye akapfekedzwa korona yepamusoro zvibodzwa zveligi, achihwina zvibodzwa makumi maviri nezviviri. Akazokundawo 1989 Supercoppa Italiana uye 1990-91 UEFA Cup panguva yake yechipiri yekirabhu. 