 Kupfuurira kweiyi ndima - Achiziva kudikanwa kweJapan kwokudzidza kubva kumasimba okuMadokero, Inoue akabatana neChōshū Five uye akaendeswa kunze kweJapan kunodzidza paUniversity College, London muEngland muna 1863. Paakadzoka naItō Hirobumi, akaedza pasina kubudirira kudzivisa hondo Hondo yeShimonoseki pakati peChōshū nemasimba emahombekombe eWestern pamusoro pekuvharwa kweStraits yeShimonoseki kune zvikepe zvekunze. Gare gare, akarwa nemauto eTokugawa shogunate muna 1864 First Chōshū Expedition, panguva iyo akakuvadzwa zvakanyanya nekurwiswa kwevaurayi, akagamuchira kukuvara kwakapotsa kuuraya, achikumbira mukoma mukuru waInue kuti agurwe musoro nekuda kwekurwadziwa kusingatsungiririki uye pakupedzisira Ikutaro Tokoro uyo aive akahwanda kubva mukutsvaga kweTokugawa shogunate nemuchinda Sanjō Sanetomi uye akamhanyira kuna Inoue akamukwevera kuburikidza neizvi nekuisa angangoita makumi mashanu masutu etatami tsono mumaronda pamuviri wese pasina anesthesia nekuda kwekukurumidzira panguva yehondo yemumba Nyaya yekuti amai vaInue vakabata Inoue ine ropa ndokuzokurudzira mwanakomana wavo mukuru kuti arege kugurwa musoro yakaunzwa mubhuku reNational Japanese re5th nguva sesimba raamai. Gare gare akaita basa rinokosha mukuumbwa kweSatchō Alliance kurwisa Tokugawa shogunate. 