 Kupindira muLatin America kwakava nhau duku yomushandirapamwe musarudzo yapurezidhendi ya1920 sezvo Harding akataura achipesana nechisarudzo chaWilson chokutumira mauto eU.S.kuDominican Republic, uye akarwisa mutevedzeri womutungamiri wenyika weDemocratic, Franklin D. Roosevelt, nokuda kwebasa rake mukupindira kweHaiti. Munyori weHurumende Hughes akashanda kuvandudza hukama nenyika dzeLatin America idzo dzaive dzakangwarira kushandiswa kweAmerica kweMonroe Dzidziso kururamisa kupindira; panguva yekugadzwa kwaHarding, US yaivewo nemauto muCuba neNicaragua. Mauto akanga ari muCuba kuti adzivirire fariro dzeAmerica akabviswa muna 1921, asi mauto eU.S. akaramba ari mune dzimwe nyika nhatu kupfurikidza noupurezidhendi hwaHarding. 