 Ramba uchinyora ndima iyi - Kufanana nababa vake Thomas, Andreas akashanda nesimba pakuvakazve Umambo hweByzantium. Nokukurumidza pashure pokudzoka achibva kuRussia, mukupera kwezhizha ra 1481, Andreas akaronga kuronga nhimbe yokurwisa vaOttoman. Panguva iyoyo, kutonga kweOttoman kweMorea kwakanga kusingachinji; muhondo ichangobva kuitika yeOttoman-Venetian, hondo zhinji dzakanga dzaitika mupeninsula. Andreas akaenda kumaodzanyemba kweItaly, nzvimbo yakajeka yekusangana yekurwisa kuburikidza neGirisi, uye aive kuFoggia muna Gumiguru nevamwe vake vepedyo, kusanganisira Manuel Palaiologos, George Pagumenos naMichael Aristoboulos. Ari kuFoggia, Andreas akawana rubatsiro rwemari kubva kuna Ferdinand I, Mambo weNaples. Kuti agadzirire, Andreas akabhadhara varwi vanoverengeka, kusanganisira Krokodeilos Kladas, musoja wechiGiriki akanga atungamirira kumukira kwakanga kusina kubudirira muMorea vachirwisa vaOttoman muna 1480. Kladas angadai akava mutungamiriri anokosha kudai Andreas akanga asvika muGreece zvinobudirira. Musi waSeptember 15, 1481, Papa Sixtus IV akanyorera mabhishopi muItaly kuti aite zvose zvavanogona kuti vabatsire Andreas kuyambuka Gungwa reAdriatic. Pasinei nezvirongwa zvake nokugadzirira, Andreas haana kumbobvira aenda kuGreece asi panzvimbo pezvo akapedza October naNovember 1481 paBrindisi neshamwari dzake dzepedyo naMambo Ferdinand I. 