 Nyorera kupfuurira kweiyi ndima - Gweta rinodzidziswa, Toombs akawana mukurumbira mumakore e antebellum somutauri muU.S. House of Representatives, uye gare gare muU.S. Seneti. Muranda, akawana nzvimbo yaaiwirirana naAlexander H. Stephens wokuGeorgia uye akatsigira kodzero dzehurumende uye kuwedzera uranda kunyika dzokumadokero. Toombs akatsigira Chibvumirano cha 1850, asi gare gare akatsigira kupatsanuka. Toombs aiva nomutauro unoratidza manzwiro uye aiva nesimba, asi tsika dzake dzakaipa uye unhu hwake husina kugadzikana zvakaita kuti basa rake risabudirire. Muhurumende yeConfederate yakanga ichangobva kuumbwa, Toombs akagadzwa kuva Secretary of State. Akatsoropodza kurwiswa kweFort Sumter, uko kwakamuisa mukusawirirana naPurezidhendi Jefferson Davis aive nechinzvimbo chaakange achishuvira, uye akasiya hurumende kuti ajoine Confederate States Army. Akava Brigadier-General, uye akakuvadzwa muHondo yeAntietam. Muna 1863, Toombs akasiya basa rake muConfederate Army kuti apinde muchiuto cheGeorgia. Iye gare gare akarambidzwa kukwidziridzwa kwepamusoro uye akasiya basa sezvo akaramba achinetsana naDavis. Hondo payakapera, akatizira kuCuba. Akadzokera kuGeorgia muna 1867, asi akaramba kukumbira ruregerero rwepurezidhendi uye akarambidzwa kubata hofisi yezvematongerwo enyika kusvikira mushure meNguva Yekugadzirisayakaguma. 