 Nyorai zvekuenderera mberi kwechikamu chino - Arsenals run of 49 league matches unbeaten came to an end with a 20 defeat at Manchester United on 24 October 2004. Chikwata ichi pasi pehutungamiri hwaWenger chakava nemumwe mushandirapamwe wakasimba muna 2004-05, asi chakapedza chechipiri kuChelsea, iyo yakapedza mwaka iine mapoinzi gumi nemaviri pamberi. Kunyaradzwa zvakare kwakauya muFA Cup; Arsenal yakakunda Manchester United pazvirango, mushure mekupedzisa pasina zvibodzwa. Kubuda kwaCesc Fàbregas mumutsara wekutanga kwakakurudzira Wenger kutengesa Vieira kuJuventus muna Chikunguru 2005. Akacherechedza vaviri ava sezvo midfield pairing yakanga isingabatsiri, uye akanzwa kuchengetedza Fàbregas kwaizobatsira ramangwana rekirabhu. Mwaka wa2005-06 wakaratidza kutanga kwenguva yekuchinja kweArsenal sezvo yaive mwaka wekupedzisira wekirabhu kuHighbury. Chikwata ichi chakapedza chiri pachinhanho chechina muPremier League uye chiri kunze kwenzvimbo mbiri dzepamusoro kekutanga pasi pehutongi hwaWenger. MuChampions League, Wenger akaunganidza dziviriro isina ruzivo iyo yakasvika kumagumo, ichikunda Real Madrid, Juventus neVillarreal uye isina kugamuchira zvibodzwa mumatanho ekurova. Mumutambo wokupedzisira neBarcelona muna Chivabvu 2006, Arsenal yakatanga kutungamira asi pakupedzisira yakarasikirwa nemutambo 2 1. Kukundwa uku kwakaitawo kuti Wenger ave mutungamiri chete akarasikirwa mumakwikwi matatu makuru eEFAFA, mushure mekunge arasikirwa neEFAFA Cup yekupedzisira neArsenal muna 2000 uye yekupedzisira yeCup Winners Cup neMonaco muna 1992. 