 Nyorai kupfuurira kweiyi ndima - Eumenes II akauya kuRoma muna 172 BC ndokupa hurukuro kuSeneti achishora zvinonzi mhosva uye kudarika kwaPerseus. Ikoku kwakapwisa Seneti yeRoma kuzivisa Hondo yechitatu yeMakedhonia 171168BC. Kunyange zvazvo mauto aPerseus akakunda vaRoma muHondo yeCallinicus muna 171 BC, mauto eMacedonia akakundwa muHondo yePydna muna June 168 BC. Perseus akatizira kuSamothrace asi akazvipa nokukurumidza pashure pacho, akaendeswa kuRoma nokuda kwokukunda kwaLucius Aemilius Paullus Macedonicus, uye akaiswa mujeri reimba kuAlba Fucens, kwaakafira muna 166BC. VaRoma vakaparadza umambo hweMakedhoniya nokugadza nyika ina dzakabatana panzvimbo payo, dzimbahwe dzadzo dziri paAmphipolis, Thessalonica, Pella, uye Pelagonia. VaRoma vakapa mitemo yakaoma yaidzivisa kubatana kwevanhu uye zvoupfumi pakati pevagari venyika idzi, kusanganisira kurambidzwa kwemichato pakati pavo uye kurambidzwa kwenguva pfupi kuchera goridhe nesirivha. Mumwe Andriscus, achizviti anobva kuAntigonid, akapandukira vaRoma ndokuziviswa mambo weMasedhonia, achikunda uto remutongi weRoma Publius Juventius Thalna panguva yeHondo yechina yeMasedhonia 150-148 BC. Pasinei neizvi, Andriscus akakundwa muna 148 BC muhondo yechipiri yePydna naQuintus Caecilius Metellus Macedonicus, ane mauto akatora umambo. Ikoku kwakateverwa muna 146BC nokuparadzwa kweCarthage neRoma uye kukunda pamusoro peAchaean League paHondo yeKorinte, zvichitanga nguva yeGirisi yeRoma uye kugadzwa zvishoma nezvishoma kwedunhu reRoma reMakedhoniya. 