 Nyorai kuenderera mberi kweiyi ndima - De Bruyne akatanga basa rake kuGenk, kwaaive mutambi wenguva dzose pavakakunda 201011 Belgian Pro League. Muna 2012, akabatana neChirungu kirabhu Chelsea, kwaakashandiswa zvishoma uye akazokweretwa kuna Werder Bremen. Akasaina neWolfsburg ye 18 mamirioni muna 2014, kwaakazvisimbisa semumwe wevatambi vakanakisa muBundesliga uye aive akakosha mukirabhu 2014-15 DFB-Pokal kuhwina. Muzhizha ra2015, De Bruyne akabatana neManchester City kune rekodhi rekirabhu 54 mamirioni. Kubvira ipapo akahwina mikombe mitatu yePremier League, mikombe mishanu yeLigi uye mukombe weFA nekirabhu. Muna 2017-18, akaita basa rakakosha muManchester City rekodhi yekuve yega Premier League timu yekuwana mapoinzi zana mumwaka mumwe chete. Muna 201920Muna 2006, De Bruyne akaenzanisa rekodhi yevanonyanya kubatsira mumwaka wePremier League uye akapihwa Player weMwaka. 