 Nyora kupfuurira kweiyi ndima - Muna 1868, Gladstone akava mutungamiriri wehurumende kwenguva yokutanga. Kugadziridza kwakawanda kwakapfuudzwa mukati meushumiri hwake hwokutanga, kubatanidza kubviswa kweChechi yeIreland uye kuiswa kwekuvhota muchivande. Pashure pokukundwa musarudzo muna 1874, Gladstone akasiya basa somutungamiriri weLiberal Party. Kubva muna 1876 akatanga kudzoka zvichibva pakushora kweOttoman Empire maitiro kuBulgaria Kubvumbi Kumuka. Mushandirapamwe wake weMidlothian wa1879-1880 waiva muenzaniso wekutanga wemaitiro akawanda ezvematongerwe enyika ezvematongerwe enyika. Mushure mesarudzo huru dza1880, Gladstone akaumba hurumende yake yechipiri 18801885, iyo yakaona kupfuurwa kweChitatu Reform Act pamwe nematambudziko muEjipitori akazoguma nekudonha kweKhartoumneIreland, uko hurumende yake yakapa mitemo yekudzvinyirira asi yakavandudzawo kodzero dzepamutemo dzevarimi veIreland. 