 Nyora kupfuurira kweiyi ndima - Fabrizio akaberekwa nguva yakati pamberi pa 1452. Akanga akaroorwa naAgnese da Montefeltro mwanasikana waFederico da Montefeltro, 1st Duke weUrbino, naBattista Sforza. Fabrizio aizivikanwa saGavhuna weTagliacozzo uye mukuru mukuru woumambo hweNaples. Munguva yeHondo yeItaly ya14991504, akatamba chikamu chakakosha muhondo yeCerignola muna 1503. Akanga ari mukuru mukuru muHoly Leagueiro rakarwa naLouis XII weFrance kubva muna 1509 kusvika muna 1515, uye paHondo yeRavenna, akatungamirira uto rePapal States kurwisa France. 