 Pamberi pekutanga kwemwaka wa201516 Isco akachinja nhamba yehembe yake kubva pa23 kuenda pa22, iyo yaakanga ambopfeka kuMalaga. Musi wa 21 Mbudzi 2015, apo Real yakarasikirwa ne04 pamba kuBarcelona mu El Clásico, akadzingwa muminiti ye84th nekuda kwekukanganisa paNeymar. Akawana zvibodzwa zviviri musi wa 2 Zvita, sezvo timu yakakunda 31 kuCádiz mumutambo wekutanga we 32 yekupedzisira mukombe wepamba. Isco akanga ari chikamu-nguva anotanga apo chikwata akakunda 2015-16 UEFA Champions League kukunda Atlético Madrid 5-3 pamusoro chirango chokupedzisiravakatamba paSan Siro, Milan. 