 Nyorai kupfuurira kweiyi ndima - Tripler aigara achichinjwa munyika yose asati ashanda muHondo yechipiri yeSeminole uye Hondo yeMexico neAmerica. Mukati meMexico City Campaignakagoverwa somutungamiriri wezvokurapa weGeneral David E. Twiggs regular division uye pashure pacho akarayirwa kuronga uye kutungamirira chipatara chikuru chemauto muguta racho. Pashure pehondo iye akapfuurira nebasa rake muNew York, Michigan, Kentucky neCalifornia. Muna 1852 Tripler akanga ari chikamu chetsvakurudzo yakapiwa basa rokufamba nomumhenderekedzo yegungwa yokumabvazuva kubva kuNew York kuenda kuPanama uko vaizofamba vachiyambuka nyika vachienda kumhenderekedzo yegungwa yokumadokero ndokukwira chikepe vachidzoka. Munguva yokufamba kuburikidza nePanama, varwi vechikwata vakatanga kuva nekuputika kwekorera, marariya, manyoka, uye dysentery iyo yakajekesa Tripler kune nzira dzisina kukwana dzekurapa dziripo neHondo. Pashure pokutanga kweHondo yeVanhu Tripler akarayirwa kuenda kuWashington, uye musi waAugust 12, 1861, akagadzwa kuva Medical Director weArmy of the Potomac. Achibatanidzwa muPeninsula Campaign ya1862, akatsiviwa naJonathan Letterman, achimanikidzwa neUnited States Sanitary Commission. Akabvumirwa kusarudza kugadzwa kwake kunotevera, uye nokudaro akava Chiremba Mukuru weDhipatimendi reMakungwa. Tripler akaramba ari pachinzvimbo ichi munguva yehondo, uye akagadzwa Brevet Brigadier General musi waKurume 13, 1865. Aongororwa aine bundu rakaipa remakenduru omutsipa mukutanga kwa1866 akafa musi waOctober 20, 1866. 