 Nyorai kupfuurira kweiyi ndima - Mumutambo wokutanga wehondo yevagari vemopakati pambuya nomuzukuru, Andronikos III akabudirira mukuzviwanira iye amene kuzivikanwa samambo muduku, neThrace senzvimbo yake yomunhu oga. Mukupesana kwose, Synadenos akanga ari pakati pevatsigiri vechidiki Andronikos vakanyanyisa uye vasingadzoreki, vachitsigira kugumiswa kwekupedzisira kwaAndronikos II. Munguva yehondo, Synadenos akakunda mauto akavimbika pasi paConstantine Asen, uye mumutambo wekupedzisira wehondo yevagari vemo, muna 132728, akashanda semutongi muThrace. Sezvo nzvimbo dzakawanda zvikuru, kubatanidza guta rechipiri rinokosha zvikurusa roUmambo, Thessalonica, dzakachinjira kumusasa waAndronikos III, Synadenos pamwe chete naKantakouzenos vakakurudzira Andronikos III kuti aende kuConstantinople ndokubvisa sekuru vake chose chose. Usiku hwaMay 13, 1328, varume vatatu vakatungamirira uto ravo nepagedhi pashure pokubhadhara varindi varo, vachitora guta guru roumambo pasina kupikiswa. Andronikos II akamanikidzwa kusiya chigaro choumambo ndokuenda kunogara mumusha wemamongi, muzukuru wake achimutsiva samambo oga. Nokuda kwemabasa ake, Synadenos akasimudzirwa kuva protostrator pane imwe nguva mukati mehondo yavagari vemo, zvichida kare muna 1321. 