 Ramba uchiverenga ndima iyi - Zvirwere zvehosha ndizvo zvainyanya kukonzera kuderera kwenhamba yevagari vemunyika iyi. Pashure pokuonana kwokutanga navaEurope navaAfrica, hosha dzeNyika Yekare dzakaparira rufu rwa 90 kusvika ku 95 yavagari vomunyika yeNyika Itsva mumakore 150 akatevera. Denda rakauraya kubva pachikamu chimwe muzvitatu kusvika kuhafu yevagari vomunyika yeHispaniola muna 1518. Nokuuraya mutongi weInca Huayna Capac, chibhokisi chakakonzera Inca Civil Warwe15291532. Denda rokutanga nderechirwere chemaperembudzi. Typhus sezvingabvira muna 1546, furuwenza nehosha pamwe chete muna 1558, hosha yehosha zvakare muna 1589, diphtheria muna 1614, manyoka muna 1618zvose zvakaparadza zvisaririra zvetsika yeInca. 