 Prost akasayina kubatana neFerrari muna 1990, achiva mutyairi wokutanga akasayina kuchikwata ichi mushure mekufa kwemuvambi wechikwata Enzo Ferrari muna 1988. Akatsiva Gerhard Berger paFerrari uye akabatana neBritish Nigel Mansell Berger akatora chigaro chaProst paMcLaren. Somukundi wenyika ari kutonga, Prost akatora basa semutyairi mukuru wechikwata uye anonzi akatamba pachinzvimbo ichi. Mansell anoyeuka chimwe chiitiko apo pa1990 British Grand Prix, motokari yaakatyaira haina kubata zvakafanana nemujaho wapfuura paakatora nzvimbo yepamusoro, uye akazoziva kubva kune vashandi vechikwata kuti Prost akaona Mansell semotokari yepamusoro uye akavashandura pasina Mansell achiziva. Prost akakunda mijaho mishanu yeFerrari gore iroro, muBrazil, Mexico, France, Britain neSpain. Chinokosha pakati paizvozvi chakanga chiri Mexican Grand Prix, uko akakunda pashure pokutanga panzvimbo yechi 13. Mumakwikwi ose eMexico neSpain, akatungamira Mansell kuFerrari 12 kupedzisa. Makundano aya akazoitwazve mumutambo wekupedzisira mumwaka uyu kuJapan naProst achitevera mukwikwidzi wake weMcLaren, Ayrton Senna, nemapoinzi mapfumbamwe. Sezvakanga zvakaita muna 1989, kurwisana kunopesana pakati pevaviri ava kwakagumisa nhangemutange yacho. Pakona yokutanga Senna, sezvaakareurura gore rimwe gare gare, akafambisa motokari yake yomumhanyi kupinda mumakwikwi aProst, achivatora vose vari vaviri kubva mumakwikwi ndokuisa chisimbiso mukurumbira wake. Zvaakaita zvaiva zvinosemesa, akadaro Prost. Iye munhu asina maturo. Prost akapedza mwaka aine mapoinzi manomwe kumashure kwaSenna, uye timu yake yeFerrari yaive yechipiri kuna McLaren. 