 Lopetegui akatanga kushanda semutungamiri muna 2003, uye akapedza makore anoverengeka achitungamirira zvikwata zvechidiki zveSpain, achitungamirira pasi pe-19 uye pasi pe-21 mativi kumatunhu eEurope. Aivewo murairidzi mukuru wechikwata chevakuru chenyika kwemakore maviri, asi akadzingwa pamberi pekutanga kweNdebe yeNyika ya2018 zvichitevera chiziviso chechibvumirano chake chekubatana neReal Madrid mushure memutambo. Mumutambo wenhabvu, akatungamira Rayo Vallecano, Castilla, Porto, Real Madrid neSevilla, kuhwina 2020 Europa Leaguenorutivi rwokupedzisira. 