 Nguva yokumutsidzirwa yakaguma pakati pezana ramakore rechi 16 nemhaka yenhevedzano yokukundikana kwechiuto. Mauto eumambo akakundwa nemaOttoman muhondo yePreveza muna 1538, ngarava dzeGenoa dzakakanganiswa nemadutu panguva ye1541 Algiers expedition, ngarava dzeGenoa-Spanish dzakakundwa paPonza muna 1552, uye ngarava dzehondo dzakatadza kumisa simba reFrance kubva mukutora Corsica muna 1553. Genoa yakatumira boka rengarava dzayo kusangano revaKristu rakakundwa nevaOttoman muHondo yeDjerbamuna 1560. Zvisinei, muna 1571 uto rehondo reGenoa rakapa ngarava 29 ngarava 53 dzose kuhondo yeHoly League muhondo inokosha yeLepanto, umo mukuru wehondo weGenoa Giovanni Andrea Doria akaparadza rutivi rworudyi rweuto reOttoman. Kukunda kwakasimba kwechiKristu kwakagumisa kutonga kweOttoman muMediterranean. 