 Rice ndiye oga akanga asingabvumirani neboka raPurezidhendi Obama rinoona nezvekuchengetedzwa kwenyika pachisarudzo chake chekutsvaga mvumo yekongiresi yekurwisa zvehondo kuSyria, zvichitevera kushandiswa kwegasi re sarin nehurumende yaAssadmukurwisa vanhuwo zvavo muna August 2013. Iye akapikisa kuti hurumende inofanira kupfuurira mberi nekurova kuranga Assad, achitaura zvakarurama kuti Congress yaisazopa mvumo. Rice naKerry gare gare vakashanda kuti vatevere mhinduro yedhipatimendi neRussia panzvimbo pezvo. Nhamburiko iyi yakatungamirira kuUnited Nations Security Council Resolution 2118, iyo yakamanikidza Syria kuparadza zvombo zvayo zvemakemikari zvakaziviswa uye kubatana neChemical Weapons Convention. Pasi pechibvumirano chacho, matani mametric 1.300 ezvombo zvemakemikoro akabviswa muSyria pasi pokutariswa nenyika dzakawanda. Zvisinei, hurumende yaAssad yakawana kana kugadzira gasi rekurwisazve makemikari muna 2017. 