 Nyora kuenderera mberi kweiyi ndima - Musi wa 26 Gumiguru 2016, Marchisio akadzokera kunhandare mushure memwedzi mitanhatu ari parutivi mukukunda kwemba 41 pamusoro peSampdoria. Akarova chibodzwa chake chekutanga kubva pakukuvara kwake mukukunda 3-1 kure neSevilla panguva yeChampions League group stage. Mwaka wakaona Marchisio achisvika zviitiko zviviri zvinokosha. Musi wa 15 Kubvumbi 2017, akaita mutambo wake we250th Serie A kuJuventus mukukunda 20 kunze kwePescara. Musi wa 21 Chivabvu 2017, akatanga mumutambo wekupedzisira wepamusha wemwaka uyu neCrotone, iyo Juventus yakakunda 3 0 kuti isimbise nhoroondo yechitanhatu yakateedzana Scudetto, izvo zvakaita kuti Marchisio ave mumwe wevatambi vatanhatu chete vanga vari muchikwata kwemwaka mitanhatu yese yakabudirira. Musi wa 3 Chikumi, Marchisio akapinda semutambi mukutamba kwake kwechipiri muChampions League Finalmumakore matatu, asi Juventus yakakurirwa 4-1 nevatsigiri veReal Madrid. 