 Nyorai kupfuurira kweiyi ndima - Muna September, Charles V akavhara Diet yeWorms kuti atungamirire, kwenguva yokutanga muupenyu hwake, hondo yechiuto, achiraira maImperial kurwisa mauto anopinda aFrancis I muLow Countries. Akabudirira kudzivirira Flanders uye akakunda muhondo paTournai, nepo mauto ePope-Imperial akatungamirwa naProspero Colonna akadzinga maFrance kubva kuMilan, akaisa Francesco II Sforza pachigaro cheDucal, uye akadzorera matunhu eParma nePiacenza kuPope States. Kubudirira ikoko kwakasimbiswa neHondo yeBicoccagore rakatevera. Papa Leo X akafira mufurati rake reRoma pashure pomutambo wakaitirwa kupemberera kukundwa kweFrance. Akatsiviwa naAdrian weUtrecht, mudzidzisi waCharles weFlemish uye mutongi wake muSpain, akaenda kuRoma kunotorwa korona saPapa Adrian VI. Muna 1522, Charles V akasarudza kusiya Netherlands ndokuenda kuSpain, zvino pasina mutongi uye uko kumukira munyika yose kwakapfuurira pamwe nehondo muNavarre. Akasimbisa Margaret wokuAustria somubati wehurumende yeNetherlands, achimudana kuti ave purezidhendi weDare Guru reBurgundian uye kugadza dare rokubvunzurudza romunzvimbomo kuti rimubatsire mukutsvakurudza nokuparadza mabhuku aLuther. Nokuda kwehutongi uye hurumende yenyika dzeAustria, Charles akaisa muchivande munununa wake Ferdinand pamwe nenharaunda idzodzo: nemibvumirano yeWorms 21 April 1521 neBrussels 7 February 1522, Ferdinand akagadzwa Archduke weAustria muzita raCharles V. Nemibvumirano imwecheteyo, Charles akavimbisa kutsigira kukwikwidza kwaFerdinand semutevedzeri akasarudzwa muHumambo uye kumupfuudza kodzero dzekugara nhaka pamusoro peAustria panguva yekutonga kweHumambo. 