 Pirlo akatungamira Milan mumaminitsi akatamba mumwaka wa2006-07 aine 2,782 mumitambo makumi mashanu nemaviri, paakaenderera mberi kuhwina mukombe wake wechipiri weEFAFA Champions League neMilan, achibatsirawo timu yake kunzvimbo yechina muSerie A, uye imwe Coppa Italia semi-fainari. Mumutambo wechipiri weEFAFA Champions League semi-fainari vachipesana neManchester United, Pirlo akaisa chinangwa chaSeedorf, sezvo Milan yakafambira mberi kusvika kumagumo. Mumakwikwi ekupedzisira e2007 UEFA Champions League muAthens, Pirlo akabatsira chinangwa chekutanga chaInzaghi kubva pakakandwa, achibatsira Milan kukunda Liverpool 21, achitsiva kukundwa kwavo muna 2005 muIstanbul. Munguva ye2007-08 mwaka, Pirlo akakunda UEFA Super Cup yake yechipirineMilan, achibatsira chinangwa chechipiri cheMilan mumutambo wekupedzisira, uye kuhwina mubairo we Man of the Match; akabatsirawo mukirabhu yekutanga FIFA Club World Cup mukombe muna 2007, zvakare achigadzira chinangwa chechipiri cheMilan mumutambo wekupedzisira. Muna Gumiguru 2007, akasarudzwa ku2007 Ballon dOr, 2007 FIFA World Player yeGore, uye 2007 International Federation of Football History Statistics IFFHS Worlds Best Playmaker Awards, asi vese vakahwinwa naMilan teammate Kaká, Pirlo akaiswa 5th muBallon dor, 7th muFIFA World Player yeGore, uye 2nd muWorlds Best Playmaker Awards. Pasinei nekutanga kwakanaka, Milan yakatambura nekudonha mufomu mukati mehafu yechipiri yemwaka, ichipedza ligi iri pachinzvimbo chechishanu, ichitadza kukwanisa kuenda kuEFAFA Champions League; Milan yakatamburawo nekubviswa mumutambo we16 weEFAFA Champions League neCoppa Italia mwaka iwoyo. Mwaka wakatevera, Milan yakabudirira kupedzisa nzvimbo yechipiri muSerie A, padivi peJuventus, uye kumashure kwevanokwikwidza vemuno Inter, nepo vakabviswa mumutambo we32 weEFAFA Cup, uye kutenderera kwe16 yeCoppa Italia. 