 Nhau yehukama hweOttoman-Safavid Persian yakatanga nekugadzwa kweSafavid madzinza muPersia Iran mukutanga kwezana ramakore rechi16. Kurwisana kwokutanga kwevaOttoman nevaSafavid kwakaguma neHondo yeChaldeiranmuna 1514, uye yakateverwa nezana ramakore rokurwisana pamuganhu. Muna 1639, Safavid Persia neOttoman Empire dzakasaina Chibvumirano cheZuhab icho chaibvuma Iraq mukutonga kweOttoman, uye chakagovana zvine mutsindo Caucasus muzvikamu zviviri pakati pemadzimambo maviri. Muchikamu chikuru, chibvumirano cheZuhab chakanga chiri kusimbiswa kweRugare rweAmasya rwakaitwa makore anenge zana akanga apfuura. 