 Nyorai kupfuurira kweiyi ndima - Pakati pa 1639 na 1649, vaBarberini vakarwa Hondo dzaCastropamwe chete nemhuri yePamphili. Baba vaMaffeo, Taddeo, naLuigi Mattei vakatungamirira mauto apapa akanga akavimbika kuna Papa Urban VIII nemhuri yaBarberini. Muna 1644, pashure peHondo yaCastro yokutanga, Papa Urban VIII akafa uye mhuri yaPamphili Pope Innocent X akasarudzwa panzvimbo pake. Papa Innocent gare gare akavamba kunzvera Antonio Barberini babamunini vaMaffeo, achimukurudzira kuti atizire kunyika yokudzingwa nevanununa vake vaviri, Francesco naTaddeo baba vaMaffeo. 