 Nyorera kupfuurira kweiyi ndima - Mutambi anotonga protagonist Booker DeWitt Troy Baker, nhengo yakanyadziswa yePinkerton National Detective Agency yakakuvadzwa nemanzwiro kubva kuzviito zvechisimba zvaakaita paHondo yeWounded Knee. Achitarisana nezvikwereti zvekubhejera, anotumirwa kuColumbia kunonunura Elizabeth Courtnee Draper, mukadzi wechidiki akavharirwa imomo kubvira achiri mudiki, uyo ane kugona kuvhura Misodzi. Kuiswa kwake mujeri kwave kuchichengetwa naSongbird, chisikwa chikuru, chakafanana neshiri chakave shamwari yake uye mutariri wake, uye icho chakarongedzerwa kunzwa kutengeswa kana Elizabeth akaedza kutiza. 