 Nyorai kupfuurira kweiyi ndima - Mwaka wegore rechipiri waRose wakatanga nekukuvara kwechitsitsinho mumutambo wake wokutanga wepamberi pemwaka. Rose aizoenderera mberi achitadza kupinda mumutambo wose wokutanga mwaka. Rose akatanga mutambo weBulls wokutanga mwaka vachipesana neSan Antonio Spurs asi akatamba maminitsi mashoma. Chitsitsinho chaRose chakamutambudza munenge muna November wose, asi sezvo chitsitsinho chake chakarapwa, mutambo wake wakavandudzika. Musi waNdira 28, 2010, Rose akasarudzwa kuti atambe mutambo wake wekutanga weAll-Starsomutsigiri weEastern Conference, achimuita mutambi wokutanga weBulls akasarudzwa kubvira pana Michael Jordan muna 1998. Rose akaguma aine mapoinzi masere, anobatsira mana uye anoba matatu mumutambo wacho. Musi waApril 13, 2010, Rose akawana mapoinzi makumi matatu nemapfumbamwe achipesana neCeltics, achiita 1522 zvibodzwa uye 910 mahara. The Bulls kamwe zvakare akaita playoffs muna 2009-10 mwaka, kupedza ane 41-41 chinyorwa. Mumakwikwi ekupedzisa Rose akaenzana 26.8 points uye 7.2 inobatsira, asi Bulls yakarasikirwa mumitambo mishanu kuCleveland Cavaliers. 