 HIV lipoatrophy is a condition marked by fat loss; it occurs in many patients taking antiretroviral ARV therapy that includes nucleoside reverse transcriptase inhibitors NRTIs. Lipoatrophy may be related to mitochondrial toxicity, a condition that can damage the heart, nerves, muscles, kidneys, and liver, and can affect the bodys ability to produce energy. NucleomaxX is a food supplement consisting of a sugar cane extract high in nucleosides, which are building blocks that may counteract the negative effects of NRTIs. Tenofovir disoproxil fumarate TDF is an NRTI that may cause less lipoatrophy than other drugs in its class, such as zidovudine ZDV or stavudine d4T. The purpose of this study is to determine whether nucleoside supplementation with NucleomaxX and substitution of TDF for ZDV or d4T in an ARV regimen can reverse fat loss caused by mitochondrial toxicity in HIV infected adults. 