 The cellular and molecular mechanisms responsible for the immunomodulatory and anti-inflammatory properties of Andrographolide, are for the most part still unknown. However, recent studies with in vitro and in vivo assays indicate that 10 micromol μM per liter inhibits Tumoral Necrosis Factor Beta NF-kB. Specifically, Andrographolide at concentrations of 10 micromol uM per liter interferes with DNA binding of NF-kB 10, by reducing the expression of COX-2 in neutrophils induced with Formyl-Methionyl-Leucyl-Phenylalanine fMLP and Platelet Activating Factor PAF. Moreover, Andrographolide reduces Interferon gamma IFNg and IL-2 production in Concanavalin A Con A induced T-cells, without affecting cell viability or inducing apoptosis, also diminishing thymocyte apoptosis induced by corticosteroids. Furthermore, Andrographolide and 14-deoxyandrographolide are capable of inhibiting extracellular signal-regulated kinases 12 ERK12 phosphorylation in T cells and neutrophils, respectively 11, 12. 