 The treatment of the dissociative disorders remains controversial. The psychotherapeutic guidelines proposed by International Society for the Study of Dissociative Disorders ISSD were recently adapted for the French speaking users Damsa et al., 2005. There is no consensus on which antipsychotic or antidepressant would be preferable for those patients who suffer from dissociative disorders, accompanied by depressive or psychotic symptoms. We have a very good clinical experience with quetiapine and escitalopram for this specific group of patients. 