 The principal investigator use a Simon two-stage minimax design based on overall response rates. Overall disease control rates will be calculated as the percent of patients that have confirmed complete response CR or partial response PR or stable disease SD by radiographic response including CT andor PET scans. We assume a P0 as 20, and designate a target rate P1 as 40. Under the error probabilities α0.05, β0.20, eighteen patients will be enrolled in the first stage. If overall disease control rate is 418 in the first stage, this study will be stopped. If not, this study will recruit patients up to 33 considering 20 of drop out rate. 