 - Cardiovascular: Participants who have severe or clinically significant cardiovascular disease uncontrolled with standard treatment. Including but not limited to: a known ejection fraction of 30 OR b severe heart failure meeting New York Heart Association Class IV classification OR c hospitalised in the 12 months prior to Visit 1 for severe heart failure meeting New York Heart Association Class III OR d angina diagnosed less than 3 months prior to Visit 1 or at Visit 1. 