 - presence of strong cardiovascular risk factors such as: serum creatinine levels 2 mgdL, diabetes mellitus, uncontrolled systemic arterial hypertension systolic blood pressure 190 mgdL or diastolic blood pressure 100 mgdL; history of cancer in the former 5 years before recruitment; not adequately treated hypothyroidism TSH levels 1,5 times the upper normal limit; 