 The main purpose of this study is to investigate the effect of SRT2104 upon energy production in muscle specifically the maximum amount of energy produced with muscle contraction, how much sugar and fat are stored in the muscle, and the size of the muscle after receiving 2.0 g of SRT2104 or placebo given in capsule form once a day for 28 days including a 14 day knee and lower leg immobilisation period during the final 14 days of dosing. 