 To evaluate the effect of both neoadjuvant regimens on clinical and pathological response rate in particular relief of dysphagia, improvement in health related quality of life HRQL, endoscopic regression, and CT-PET evidence of tumour response, tumour regression grade, node-positivity, post-operative pathology, disease-free survival, time to treatment failure, toxicity, post-operative complications and Health Related Quality of Life HRQL. 