 5. Female subjects should be either post-menopausal amenorrhea for at least 24 consecutive months, surgically sterile, or women of child-bearing potential WOCP with a negative urine beta human chorionic gonadotropin HCG pregnancy test prior to entering the study and who are using or agree to use acceptable methods of contraception. Abstinence is an acceptable means of avoiding pregnancy as long as the subject agrees to use contraception if they become sexually active. Acceptable contraceptives include intrauterine devices IUDs, hormonal contraceptives oral, depo, patch or injectable in use for one month prior to screening and double barrier methods such as condoms or diaphragms with spermicidal gel or foam. 