 Active infection is defined as requiring treatment with antiviral therapy or presence of positive test results for Hepatitis B Hepatitis B surface antigen HBsAg andor total Hb core antibody anti-HBc or Hepatitis C Hepatitis C virus HCV antibody. Unless required by local regulations, patients are not required to have HIV, HCB, or HCV assessments at screening if these assessments have not been previously performed. 