 - Histologically confirmed transitional cell carcinoma or mixed histologies containing a component of transitional cell carcinoma of the urothelium renal pelvis, ureter, bladder, urethra with manifestations of progressing regional or metastatic cancer; or 2 Nontransitional cell histologies include patients with adenocarcinoma or squamous cell carcinomas representing greater than 90 of specimen; patients with small cell carcinoma, soft tissue sarcomas, or carcinosarcomas are excluded 