 On the day of surgery, the patients will take one pill of 1.0 mg medication or matched placebo before surgery. They will resume taking the medication as soon as possible after surgery according to the treatment schedule. At 24 hour after surgery or discharge time for day-surgery patients, i.e. the postoperative visit, patients will receive the rest of medications for the whole treatment period, i.e. two bottles of the medication or placebo each one containing 66 X 1.0 mg tabs 28 days X 2 tablets 56 tablets plus10 for a 5-day window for the rest of treatment. 