 Since there is no precedent in the literature showing preliminary data to allow for sample calculation, will aim to have complete data on 26 patients per group 10 CTP A, 8 CTP B, and 8 CTP C in each group. However, given that the estimated attrition rate in Group B is 30, will aim to recruit up to 34 patients for this group. We are planning on recruiting one control for each subject in control B, so that the number of controls would not exceed 34. Thus, the total number of subjects in study will be no more than 94. This number should allow more than the minimum needed to perform correlation analyses between and within groups with confidence. 