 - Clinically significant cardiac disease or impaired cardiac function such as: congestive heart failure requiring treatment NYHA II; eft ventricular ejection fraction LVEF 50; significant cardiac arrhythmia; atrial fibrillation; conduction abnormality such as congenital long QT syndrome or high gradecomplete atrioventricular AV-blockage; acute coronary syndrome including myocardial infarction, unstable angina pectoris, coronary artery bypass graft, coronary angioplasty or stenting, if 3 months prior to registration; QTcF 480 msec at screening 