 12. Clinically significant, uncontrolled heart disease andor cardiac repolarization abnormalities, including any of the following: a.History of acute coronary syndromes including myocardial infarction, unstable angina, coronary artery bypass grafting, coronary angioplasty, or stenting or symptomatic pericarditis within 6 months prior to screening. b. History of documented congestive heart failure New York Heart Association functional classification III-IV. c.Documented cardiomyopathy. d. Left Ventricular Ejection Fraction LVEF 50 as determined by Multiple Gated acquisition MUGA scan or echocardiogram ECHO at screening. e. clinically significant cardiac arrhythmias e.g. ventricular tachycardia, complete left bundle branch block, high-grade AV block e.g. bifascicular block, Mobitz type II and third-degree AV block 