 In this prospective study, patients undergoing elective liver resection with inflow occlusion Pringle maneuver at UH, Newark will be randomized 1:1 to either standard anesthetic management with Propofol No APC group or anesthetic preconditioning with 2 minimum alveolar concentration MAC of isoflurane APC group. Because preexisting liver disease, especially cirrhosis, is an important determinant of post operative outcomes, and to balance the randomization of subjects regarding this important variable randomization will be stratified into those with and without preexisting liver disease. The primary endpoint is the occurrence of postoperative complications grade IIIb or greater Claviens classification. The secondary endpoints are peak postoperative aspartate and alanine aminotransferase AST and ALT and total bilirubin T Bili, length of ICU and hospital stay, and a decrease in liver lipid peroxidation and apoptosis 