 - Patients with: any medical conditions that would limit study participation, pregnancy, myocardial infarction within 30 days of enrollment, hemodynamically significant valvular disease, HF due to thyroid disease, myocarditis, restrictive or hypertrophic cardiomyopathy, cor pulmonale PVR5 Wood units with RV dysfunction, LV thrombus, atrial fibrillation or other persistent irregular rhythm, dyspnea felt predominantly due to pulmonary disease, significant coronary artery stenoses 70, or 50-70 with FFR0.8 or other abnormalities detected during the clinical catheterization procedure which require revascularization or other directed therapy. 