 - History of serious systemic disease, including myocardial infarction or unstable angina within the last 12 months, history of hypertensive crisis or hypertensive encephalopathy, uncontrolled hypertension blood pressure of 14090 mmHg on medication, New York Heart Association NYHA Grade II or greater congestive heart failure, unstable symptomatic arrhythmia requiring medication subjects with chronic atrial arrhythmia, i.e., atrial fibrillation or paroxysmal supraventricular tachycardia are eligible, significant vascular disease or symptomatic peripheral vascular disease. 