 Secondary endpoints include measurements of the following: Neurological score by the Friedreichs Ataxia Rating Scale FARS, gait record and analysis of its components, posture study, kinetic study of the upper limbs, speech, oculomotor and auditory disorders, functional handicap using the Disability Status Scale DSS, quality of life by SF-36 score; Cardiac involvement electrocardiography, 24 hours holter, echocardiography with tissue doppler and drug tolerance. 