 - Adequate biological examination: Hb or 9 gdl, polynuclear neutrophils or 1,500mm3, platelets or 100,000mm3, total bilirubin or 1.5 x UNL, creatinine clearance, calculated according to Cockroft-Gault formula, 50 mlmin creatininemia 1.5 x UNL, ALP 5 x UNL, transaminases 5 x ULN, GGT 5 x UNL 