 11. History or evidence of cardiac disease: congestive heart failure; New York Heart Association NYHA class 2 or greater see Appendix 6; active coronary artery disease; unstable angina, cardiac arrhythmias requiring anti-arrhythmic therapy, atrio-ventricular block of second or third degree, or uncontrolled hypertension, patients with recent less than 6 months myocardial infarction MI or coronary revascularization. 