 - Use of any prescription drugs, herbal supplements, within four 4 weeks prior to initial dosing, andor over-the-counter OTC medication, dietary supplements vitamins included within two 2 weeks prior to initial dosing note that diazepam interferes with the analysis of DSM265 and should not have been used for 8 weeks prior to initial dosing. If needed, i.e. an incidental and limited need paracetamol is acceptable up 4 gday. 