 - Are in good health, as determined by vital signs oral temperature, pulse, and blood pressure, medical history, and targeted physical examination based on medical history to ensure any existing medical diagnoses or conditions except those in the Subject Exclusion Criteria are stable . Subjects may be on chronic1 or as needed prn medications if, in the opinion of the site principal investigator or appropriate sub-investigator, they pose no additional risk to subject safety or assessment of reactogenicity and immunogenicity. Note: Topical, nasal, and inhaled medications with the exception of steroids as outlined in the Subjects Exclusion Criteria see Section 5.2, vitamins, and contraceptives are permitted. 