 - Inadequate liver function as demonstrated by serum bilirubin 2.5 times the upper limits of reference range ULRR or alanine aminotransferase ALT or aspartate aminotransferase AST or alkaline phosphatase ALP 2.5 times the ULRR unless due to the presence of liver metastases when ALT andor AST may be up to five times the upper limits of reference range. Patients with an isolated increase in ALP 5 times ULRR in the absence of liver metastases but with known bone metastases are eligible for the study. 