 This study uses two stage group-sequential sampling design, based on current data, assumed the CIPN incidence rate is 50 in placebo arm, while 20 in PerOx Quench arm60 reduction, set a0.05,80 power, random allocation ratio is 1:1, obtained the subjects number is 41total 82 by PASS 11 software for superior design; considering 10 drop out rate, final number of subjects totally is 90. 