 Study Hypotheses: We hypothesize that resuscitation with 5 albumin as compared to normal saline in early septic shock may exert some of its protective effects through the following biological mechanisms: 1 Limiting thrombin generation, 2 Supporting endogenous protein C and activated protein C APC generation, 3 Limiting the production of systemic pro-inflammatory cytokines and chemokines and supporting the production of cytokines and chemokines with anti-inflammatory potential, and 4 Reducing the ability of septic plasma to generate Neutrophil Extracellular Traps NETs. 