 - Subject has a mean pulse 40 or 90 bpm; mean systolic blood pressure SBP 140 mmHg; mean diastolic blood pressure DBP 90 mmHg vital signs measurements taken in triplicate after subject has been resting in supine position for 5 minutes; pulse will be measured automatically on admission to the clinical unit on Day -1. If the mean blood pressure exceeds the limits above, 1 additional triplicate can be taken. 