 The need to understand LABC is especially compelling in populations and countries with limited resources, where breast cancer incidence is relatively low, but mortality is comparably high. In these settings access to appropriate cancer care is characteristically limited or often plainly nonexistent. In contrast to economically developed nations, where on average fewer than 20 of women present with breast cancer at advanced stages, LABC and metastatic disease are the most common stages at presentation in 50 or more women in Latin America, Asia and Africa. 