 Dosage and Administration: For the medication of patients enrolled in the treatment arm, one CBPG unit mean volume 10 ml, range 5-15; mean platelet concentration 1 x 109L 0.8 - 1.2 x 109L will be administered every 3-4 days. CBPG units, cryopreserved and stored in a small plastic bag in a -80C freezer, will be thawed at 37C in a waterbath and activated with Calcium gluconate and immediately transported to sites of clinical use and applied to the skin ulcer without breaking the sterility chain. 