 Subjects will be randomized to one of six treatment groups MFF MDI 10010 mcg BID, MFF MDI 20010 mcg BID, MFF MDI 40010 mcg BID, MF DPI 200 mcg BID, MF MDI 200 mcg BID, or Placebo MDI BID according to an Schering-Plough Research Institute SPRI computer-generated randomization schedule. Randomization will be performed in appropriately sized blocks using random numbers generated by statistical analysis software SAS. 