 - with serious hematologic dysfunction white blood cell count of 3.0×103uL; absolute neutrophil count of 1.5×103 uL; platelet count of 75×103uL; hemoglobin level of 8.0 gdL; hepatic dysfunction total bilirubin level of 1.5×ULN; aspartate amino transferase AST and alanine amino transferase ALT levels of 2.5 × ULN; renal dysfunction serum creatinine level of 1.5×ULN ; and International normalized ratio INR and partial thromboplastin time or activated partial thromboplastin time aPTT 1.5 × ULN unless on therapeutic coagulation 