 The L-enteroendocrine colonic cells are responsible of secreting anorexic gut hormones PYY and GLP-1 physiologically in response to food. These hormones are capable of inducing satiety through signalling the brain appetite centre Murphy Bloom 2006. Propionate-induced FFAR2 activation have found to cause the release of these hormones in vitro. Moreover, NDC ingestion was found to stimulate the release of these hormones in animals, resulting in decreasing food ingestion Delzenne et al. 2005. Propionate was shown to replicate the same effects in further studies, suggesting the owning of the beneficial effects of NDC on appetite and gut hormones to propionate production. 