 - Use of any herbal remedy eg, St. Johns wort Hypericum perforatum Note: Granulocyte colony-stimulating factor G-CSF and other hematopoietic growth factors may be used in the management of acute toxicity, such as febrile neutropenia, when clinically indicated or at the investigators discretion. However, they may not be substituted for a required dose reduction. Subjects are permitted to take chronic erythropoietin. 