 In patients allocated to endoscopic plication, endoscopic full-thickness plication will be performed using the GERDX system. All procedures will be performed under general anesthesia. Savary-guidewire will be placed into the stomach using a gastroscope. The GERDX system will be introduced over the guidewire and into the stomach. The subsequent procedure will be performed as described in previous studies, using a similar device NDO Plicator. According to study protocol, at least 2 pretied transmural pledgeted sutures will be deployed to achieve a tight closure of GE junction around the endoscope. In sham procedure, identical technique will be followed by positioning the plicator 1cm below the GE junction but sutures will not be deployed. 