 B.Patients should have no autoimmune diseases that have required treatment such as, Addisons disease, Hashimotos thyroiditis, or systemic lupus erythematous, Sjogren syndrome, scleroderma, Goodpasture syndrome, and active Graves disease. Also excluded are patients with autoimmune hemolytic anemia, ulcerative and hemorrhagic colitis, endocrine disorders e.g., thyroiditis, hyperthyroidism, hypothyroidism, autoimmune hypophysitishypopituitarism, and adrenal insufficiency, sarcoid granuloma, myasthenia gravis, polymyositis, and Guillain-Barre syndrome. Patients with a history of autoimmunity that has not required systemic immunosuppressive therapy or does not threaten vital organ function including CNS, heart, lungs, kidneys, skin, and GI tract will be allowed. 