 Use in the last 7 days of oral anticoagulant or any other antiplatelet drug beside ASA Active bleeding Pregnancy or woman of childbearing age without contraceptive method Hemoglobin 10 gdL or hematocrit 30 , hematocrit 50 , platelets 100.000mm3 or 500.000mm3; creatinin clearance 50 mlminute Percutaneous coronary intervention PCI on the last 30 days before randomization or PCI on the last year when drug-eluted stents are used; CABG surgery on the last 90 days; acute coronary syndrome on the last 60 days Active malignant neoplasm Active peptic ulcer disease on the last 60 days or upper gastrointestinal bleeding any time in life Refuse to participate in the study 