 6. Known history of myocardial infarction within 1 year, NYHA class IIIIV heart failure, or uncontrolled cardiovascular conditions including cardiac arrhythmias, congestive heart failure CHF, angina, or electrocardiographic evidence of acute ischemia or active conduction system abnormalities. Recent evidence within 6 months before first dose of study drug of a left-ventricular ejection fraction 50. 