 For primary outcome measure, investigators will use χ2 test to assess relationship between the primary outcome and some of the binary nature secondary measures. Stratification will be used for analysis as needed. In that case, chi-square tests for overall and within relevant stratifications will be conducted. To assess the difference between continuous variables such as hemoglobin A1C, bicarbonate, anion gap, Creatinine etc., t-test will be used for normally distributed data. Otherwise Mann-Whitney U test will be used. P-values at 95 CI will be reported. Since it is a superiority trial, we will use one-tail test for significance. 