 - Part 1 has Moderate to Severe Renal Impairment equivalent to NKF KDOQI Stage 3 or 4, not receiving dialysis as determined by estimated Glomerular Filtration Rate eGFR calculated by the abbreviated MDRD equation, OR has Normal Renal Function determined by creatinine clearance CLCR via the Cockcroft-Gault equation, using serum creatinine and demographic data, obtained at Screening. Subjects with Normal Renal Function should have no greater than trace blood or protein on Screening urinalysis. 