 The three good data sets will be averaged to reduce variability. Statistical analysis will be carried out using an appropriate statistical package to determine if any significant differences exist in the data between the three patient groups and between the patient groups and the control group. All data will be tested for parametricity. Parametric data will be analysed using analysis of variance ANOVA tests with post hoc Bonferroni correction. If the data is found to be nonparametric, KruskalWallis tests will be used. For data over time appropriate repeated measures analysis will be used. A 95 confidence level will be used throughout. 