 Adequate bone marrow reserve: absolute neutrophil count ANC 1.5 X 109L, platelets 160 X 109L, hemoglobin 12 gdL Hepatic: total bilirubin within normal limits 1.0 mgdL; alkaline phosphatase AP, aspartate transaminase AST and alanine transaminase ALT 1.5 X ULN upper limit of normal Renal: Serum creatinine 1.3 mgdL. Patients with serum creatinine 1.3 mgdL may be eligible if creatinine clearance CrCl 55 mLmin based on the standard Cockroft and Gault formula. 