 Scientific Background and Significance: Vascular endothelial growth factor VEGF is found in most tissues, and is known to regulate angiogenesis in both normal e.g. ovulation and abnormal e.g. malignant tumors conditions. VEGF has been found to be overexpressed in several tumor types, including breast, bladder, uterine, cervical, and relevant to this application, primary and metastatic tumors of patients with advanced ovarian cancer. It is widely believed that the overexpression of this factor contributes to tumorigenesis by supplying a conduit through which oxygen and nutrients can reach and feed the growing malignancy. 