 - Diagnosis of any of the following: Parkinsons disease; chronic liver disease cirrhosis, chronic hepatitis, etc.; systemic rheumatic condition rheumatoid arthritis, psoriatic arthritis, Reiters disease, systemic lupus erythematosus, etc.; end stage renal disease; or other systemic diseases or abnormal laboratory values which would preclude participants from safely participating in the protocol or impair their ability to complete the study 