 This research study investigates the benefits and possible risks of adding both etanercept Enbrel and ECP extracorporeal photopheresis to the conventional preventative or prophylactic treatments for graft-versus-host disease GVHD. GVHD is a common, serious, and too often fatal, complication after matched unrelated donor stem cell transplantation, regardless of the pre-transplant conditioning regimen used full or reduced intensity. 