 - History of exposure to the following cumulative doses of anthracyclines: Doxorubicin or liposomal doxorubicin 500 milligram per meter-square mgm2; Epirubicin 900 mgm2; Mitoxantrone 120 mgm2. If another anthracycline, or more than one anthracycline, has been used, the cumulative dose must not exceed the equivalent of 500 mgm2 doxorubicin 