 - Worsening of asthma in the 4 weeks preceding the screening visit requiring daily use of nebulised β2-agonists or any use of long acting β agonists LABA, or requiring inpatient hospitalisation for asthma control, or requiring emergency room treatment, or requiring systemic corticosteroids for asthma control or respiratory infection in the 4 weeks preceding the first screening visit or prior to randomization Day 1. 