 6. Major cardiac-related diseases, medications, or laboratory abnormalities including the following: a Clinically unstable cardiac disease, including unstable atrial fibrillation, symptomatic bradycardia, unstable congestive heart failure, active myocardial ischemia, or indwelling temporary pacemaker, b Ventricular tachycardia or a supraventricular tachycardia that requires treatment with a Class Ia antiarrhythmic drug eg, quinidine, procainamide, disopyramide or Class III antiarrhythmic drug eg, sotalol, amiodarone, dofetilide. Use of other antiarrhythmic drugs is permitted. c Use of medications that have been linked to the occurrence of torsades de pointes, d Second- or third-degree atrioventricular AV block unless treated with a permanent pacemaker, e Complete left bundle branch block LBBB, f History of long QT Syndrome or a family member with this condition, 