 They received daily estradiol hemihydrate E2 2mg norethisterone acetate NETA 1mg Kliogest, Novo Nordisk, Denmark and were randomized to get additional Boneplac, which consisted of either 800mg clodronate Bonefos, Leiras Ltd, Finland n55, KB-group or placebo n55, K-group. In case of contraindications or refusal from HT, the women were offered clodronate 800 mgday n57, B-group to be taken to empty stomach with a glass of water 30 minutes to two hours before breakfast. 