 5. Severe, active co-morbidity, defined as follows: Unstable angina andor congestive heart failure requiring hospitalization within the last 6 months; Transmural myocardial infarction within the last 6 months; Acute bacterial or fungal infection requiring intravenous antibiotics at the time of registration; Chronic Obstructive Pulmonary Disease exacerbation or other respiratory illness requiring hospitalization or precluding study therapy at the time of registration; Hepatic insufficiency resulting in clinical jaundice andor coagulation defects Note, however, coagulation parameters are not required for entry into this protocol; Pre-existing grade 2 neuropathy; Prior organ transplant. 