 In addition to gastroscopy and histology, which are the gold standards for screening and prevention of gastric cancer, several other approaches, some of them are non-invasive, were suggested. Acid hyposecretion can be measured directly or indirectly, mucin output can be measured in gastric secretion collected by a naso-gastric tube and mucin species identified by dot-blot for gastric mucins MUC5AC, MUC6 and MUC1, H. pylori status can be defined with 13C-UBT, serology or stool antigen test, pepsinogen I, pepsinogen II, gastrin and B12 can be measured in the serum. The combination of the procedures mentioned above may contribute to an accurate characterization of the high-risk individual, suitable for invasive procedure such as gastroscopy with biopsies. 