 The study is a prospective, multicentre observational cohort study. Clinical data will be captured prospectively using CRFs at baseline, surgery, postoperative and 18 months outcome. Patients will complete QoL questionnaires at 6 weeks, 6 months, 12 months, 18 months and 24 months postsurgery. For patients undergoing neoadjuvant chemotherapy, they will also complete a prechemo questionnaire 