 The NAFLD Database 2 will recruit at least 1,500 new adult participants suspected or known to have NAFLD or NASH-related cirrhosis and will also invite adult participants from the prior NAFLD Database and related studies PIVENS trial and TONIC trial to enroll in the NAFLD Database 2. To elucidate, through the cooperative effort of a multidisciplinary and multicenter group of collaborators, the etiology, natural history, diagnosis, treatment, and prevention of NAFLD, and in particular its more severe form of NASH and its complications. 