 - Aminotransferases AST, ALT 2.5 ULN 5 ULN in case of diffuse hepatic involvement, INR 1.5 following vitamin K1 injection in patients with current or recent history of jaundice or bile duct obstruction, serum creatinine clearance calculated 50 mLmin1.73m2 according to the Modification of Diet in Renal Disease MDRD formula, neutrophils 1.5.109L, platelets 100.109L, hemoglobin 9 gdL red blood cell transfusion is allowed if needed. 