 Study population: Subjects will be up to 73 adult cigarette smokers averaging greater than or equal to 10 cigarettes daily for greater than or equal to one year with current nicotine dependence based on DSM-IV criteria or Faerstrom Test for Nicotine Dependence score greater than or equal to 3. Subjects will not have other current major psychiatric disorders or substance abuse. Subjects in the pilot phase one fMRI and one TMS session to valid brain mapping procedures will be up to 25 healthy non-smokers. 