 Specifically, individuals who inherit DNA sequence variants in the TP53 gene have a greater than 90 chance of developing cancers in their lifetimes and often develop multiple sequential cancers during their lives. Women who carry a TP53 mutation have an 82 chance of developing cancer before age 45 Chompret A et al. 2000 and, in general, the average age of onset of cancer for individuals carrying TP53 mutations is 28 years old, but these statistics do not take into account other factors, such as the type of mutation present and the genetic background and settings in which the carriers live. Ruijs et al. 2010; Sagne et al. 2014; Petitjean et al. 2007 Individuals who ultimately develop cancer and harbor inherited TP53 gene mutations are described in the medical literature as having Li-Fraumeni Syndrome. Unfortunately, TP53 mutation-carrying relatives of individuals with either frank Li-Fraumeni syndrome or who carry mutations in the TP53 gene that have not yet developed cancer have an even more elevated risk of developing cancer.Hwang et al. 2003; Nichols et al. 2001 In addition, it has been shown that anticipation occurs in families with Li-Fraumeni syndrome, such that the age of onset of cancer formation is earlier from generation to generation, putting those TP53 mutation carriers with older relatives who developed early onset cancer at even greater risk of developing cancer early in life. Trkova et al. 2002; Arrifini et al. 2015 