 The aim of the study is to compare the effects of an intensive 4 weeks exercise training program with or without additional treatment with antioxidants. 16 volunteers are included into the study and randomized into a treatment n8,Vitamine E 400 IU od vitamine C 1g twice daily and a non-treatment n8, training only group. Before and after the training program, skeletal muscle biopsies will be taken to measure PGC-1alpha and PPARgamma mRNA expression. In addition before and after the training program individuals will have the following measurements: body weight, waist circumference, body fat content DEXA scan, euglycemic-hyperinsulinemic clamps, ergospirometer VO2 max, routine laboratory measurements, serum malondialdehyde concentrations. 