 There is increasing recognition that coordinated approaches to disease management improve medication adherence. Intervention in chronic illness may be viewed as a multidisciplinary and collaborative process based upon behavioral principles, including the idea that illness management skills are learned and behavior is self-directed, motivation and self-efficacy can affect self care, monitoring and responding to changes in physical and mental health improves adaptation to illness, and the health care system can support or hinder self care. Preliminary findings suggest that telemedicine home monitoring providing cues to medication administration, brief evaluation of potential barriers e.g., fatigue, cognition, side effects, identification of areas for future education e.g., additional injection training, and an opportunity for feedback to providers e.g., side effects are well tolerated and may improve self monitoring of chronic medical conditions. 