 - Plan to use medications that are reported to exacerbate acne e.g., mega-doses of certain vitamins, such as vitamin D 2000 IU per day and vitamin B12 1 mgday, haloperidol, halogens e.g., iodide and bromide, lithium, hydantoin, and phenobarbital, because these may impact efficacy assessments. Subjects who plan to use multivitamins, iron supplements and folate are acceptable. 