 Retrospective data showed that septicemia was seen in 24 of 300 8 and 15 of 897 1.7 in patients receiving peri-procedure ciprofloxacin alone and patients receiving ciprofloxacin plus single IV dose of amikacin injection respectively p0.001. E. Coli resistant to quinolones was responsible for 33 of 39 84.6 septicemic cases. In a retrospective study in UK, 12.9 developed infectious complications following prostate biopsy in patients receiving co-amoxiclav and gentamycin. 