 - Exclusion criteria: pregnancylactation, suicidal behavior requiring hospitalization or borderline personality disorder, substance dependence, psychotropic or cholesterol-lowering medication, intolerance or lack of response to the study medication, unstable or inadequately treated medical illness angina pectoris, hypertension, congestive heart failure, involvement in the planning and conduct of the study, participation in the present study or in another drug trial within 4 weeks prior enrolment in study or longer in accordance with local requirements, cytochrome P450 3A4 inhibitors and inducers, absolute neutrophil count ANC equal or less than 1.5 x 109L, unstable Diabetes Mellitus DM or opposition of physician responsible for patients DM. 