 OUTLINE: This is a multicenter, randomized, controlled study. Patients in group 1 are stratified according to prior therapy prostatectomy vs radiotherapy vs prostatectomy and radiotherapy, relapse-free interval 2 years vs 2 years, type of planned androgen deprivation therapy ADT continuous vs intermittent, and participating center. Patients in group 2 are stratified according to type of planned ADT continuous vs intermittent, disease type localized vs metastatic, and participating center. Patients in both groups are randomized to 1 of 2 treatment arms. 