 Control group: Usual treatment of CRPS according to the Dutch CBO CRPS guideline 2006 including, analgesics WHO pain ladder, neuropathic drugs, N-acetylcysteine, calcium channel blocker, ketanserin and DMSO dimethylsulphoxide. On indication, percutaneous sympathetic blocks or spinal cord stimulation will be performed. In addition, patients receive physical therapy with exercises within pain limits pain contingent, splints and if necessary, aids for ADL activities. 