 Finally the study will be completed in vitro, using an hip simulator, to reproduce the possible clinical scenarios leading to hip noise, record, and analyse it in a reproducible and robust manner. This would make possible a diagnostic approach able to correlate the involved factors to clinical occurrences, on the basis of the recorded frequencies. Second point will be studied through the dosage of circulating ions, deriving from the articular surfaces and through the histological classification of vasculitis in periimplant tissues. There is increasing evidence, indeed that locale release of submicron particles worn out from articular surfaces can release metal ions mainly Chromium and Cobalt responsible for lymphocyte local infiltration. In particular cluster of differentiation antigen 20 CD20 positive B lymphocyte and cluster of differentiation 3 CD3 positive T lymphocyte and sometimes cluster of differentiation antigen 68 CD68 positive plasma cells are present. The cells could indicate a specific phlogistic condition responsible for pain and eventually subsequent revision. 