 It is estimated that in Taiwan the incidence of resolved HBV infection in the general population is about 50. A recent survey of HbsAg-blood donors indicated that 7 of the donors had detectable HBV DNA in serum. The incidence of diffuse large B-cell non-Hodgkins lymphoma in Taiwan is 700-800 new patientsyear Taiwan Cancer Registry, We plan to enroll 150 patients in three years 50 new patients every year. 