 The study will take place at the research facility of the Center for Translational Research on Aging and Longevity CTRAL, Texas AM University. The subject will be asked to arrive in the fasted state on both the screening and all study days. On the screening day, body weight and height will be measured and Dual-energy X-ray absorptiometry DXA will be performed to measure body composition. On both SD and LD a medical interview will be performed and a toxicity questionnaire completed see attached protocol. Furthermore on a SD two blood samples will be taken up to 30 ml. On a LD, one catheter will be inserted in the peripheral vein of an arm for blood sampling 18 samples in total, up to 80 ml per LD and questionnaires related to cognition, health status and well being may or may not be completed by the subject see attached protocol. After a baseline blood sample is taken, a stable isotope pulse is provided through the same line. The baseline sample will be used to test toxicity parameters in blood, plasma homocysteine concentration, the plasma concentrations of products of the methionine degrading transamination and sulfoxidation route, and to establish background enrichment of stable isotopes. Samples obtained after the pulse will provide information about transmethylation of methionine, and GSH synthesis. Subjects will be called every week to check compliance regarding supplement intake and to answer questions regarding health and well-being. Subjects who discontinue the study during the study will not be replaced. 