 8. Patients with active Tuberculosis TB or history of active TB, positive chest X-ray for TB, or positive defined as induration of 5mm purified protein derivative PPD skin test, positive QuantiFERON, or patients having close contact with an individual with active TB. Patients having a PPD skin test 5 mm or a positive QuantiFERON test can enter the study, provided that active TB is excluded and provided that they are adequately treated for latent TB e.g., isonicotinic acid hydrazide INH therapy for 9 months with vitamin B6 and provided that appropriate treatment is initiated simultaneously with the first administration of ACTH. 