 Clinical response to therapy relative to their initial pharmacokinetic and pharmacodynamic indices for amphotericin-B i.e. daily free maximal concentration divided by the MIC would be assessed in these 6 intensively studied patients. Clinical parameters assessed would be 1. time to fever defervescence; 2. time to white cell count resolution, and 3. improvements in respiratory gas exchange i.e. specifically the rate of rise of the pressure of arterial oxygen Pa02 divided by the fraction of inspired oxygen Fi02 delivered through the ventilator or PF ratio. 