 Immunogenicity of PCV10 in Kathmandu We previously conducted an open-label, parallel group, randomised controlled trial at Patan Hospital, Kathmandu, Nepal from June 2010 to November 2011 with follow-on between February and October 2013. In this study we compared the then WHO recommended PCV schedule of three priming doses in early infancy 6, 10, and 14 weeks to a two-dose prime 6 and 14 weeks and boost at 9 months of age. We demonstrated using the ten-valent PCV PCV10 that the two-dose prime with booster at 9 months provided analogous immunogenicity to the three-dose prime schedule during early infancy, with improved protection through early childhood. 