 Progression-free survival PFS and overall survival OS would be estimated using the Kaplan-Meier method and two-tailed log-rank test.The Cox proportional hazards model would evaluate prognostic factors for OS and PFS. Specificity, sensitivity and cut-off would be established using time-dependent receiver operating characteristic ROC curve analysis. Area under curve AUC values 0.7 indicate that the parameter can be used for diagnosis, with values 0.9 indicating high clinical accuracy. 