 - Patients must have metastatic disease which is measurable, defined as at least one lesion that can be accurately measured in at least one dimension longest diameter to be recorded for non-nodal lesions and short axis for nodal lesions to 20 mm in the long axis by chest x-ray, 10 mm in the long axis by spiral computed tomography CT, magnetic resonance imaging MRI, calipers, or clinical exam, or 15 mm in the short axis for lymph nodes 