 - All patients must have measurable disease as defined by Response Evaluation Criteria in Solid Tumors RECIST 1.1; measurable disease is defined as at least one lesion that can be accurately measured in at least one dimension longest diameter to be recorded; each lesion must be 10 mm when measured by computed tomography CT, magnetic resonance imaging MRI or caliper measurement by clinical exam; or 20 mm when measured by chest x-ray; lymph nodes must be 15 mm in short axis when measured by CT or MRI 