 2. Patients with acute kidney injury AKI defined as either 1 Acute Kidney Injury by the Kidney Disease Improving Global Outcomes KDIGO Acute Kidney Injury Guideline serum creatinine criteria, which is a 50 rise in serum creatinine over baseline or a 0.3 mgdL SCr rise in 48 hours, OR 2 as Acute Kidney Injury as defined by the pediatric modified RIFLE criteria pRIFLE which is a 25 reduction in estimated creatinine clearance, OR 3 a serum creatinine 1.2 mgdL. 