 9. Patients must have normal organ and marrow function as defined: leukocytes 3,000mcL, absolute neutrophil count 1,500mcL, platelets 100,000mcL, hemoglobin 9.0gdL, total bilirubin 1.5 x upper limit of normal ULN higher is allowed if in the setting of known Gilberts disease, ASTSGOTALTSGPT 2.5 x institutional upper limit of normal or 5 x ULN if liver metastases are present, Alkaline phosphatase 3.5 x institutional upper limit of normal or 6 x ULN if liver metastases are present, creatinine clearance 50 mLmin1.732 by Cockcroft-Gault equation creatinine clearance 140-agex body massplasma creatinine x 72 x gender correction factor or by 24-hour urine collection. 