 - Systemic mastocytosis-associated hematologic non-mast cell disease SM-AHNMD as confirmed by WHO diagnostic criteria, and the patient also has at least 1 C-finding attributable to systemic mastocytosis SM. The AHNMD must be myeloid, with the following exceptions that are excluded: Acute myeloid leukemia AML, Myelodysplastic syndrome MDS that is very high- or high-risk as defined by the International prognostic scoring system for myelodysplastic syndromes IPSS-R and Philadelphia chromosome positive malignancies. 