 - Participants assigned to gel, film or insert, will insert one dose Dose 1 vaginally in the clinic. Vaginal swabs will be obtained in the clinic approximately 15 minutes after product use. Participants will be given vaginal swabs for home use. Participants will be instructed to obtain vaginal swabs, at bedtime daily, for 7 days, starting at the first bedtime after V2. Vaginal swabs will be stored in the participants refrigerator and returned to the clinic at V3. V3 will occur 7 - 10 days after V2. 