 - Treatment of bone and joint infection in which therapy for Gram-positive organisms is required, as determined by the treating physician and treatment of at least 4 weeks is planned. Bone and joint infection and trauma-associated bone and joint infection will defined clinically using radiologic e.g., MRI andor surgical e.g., intra-operative findings definitions. All subjects must have confirmation diagnosis mentioned in chart by the patients primary physician and consultants that the patients has or likely has bone and joint infection and requires prolonged antibiotic therapy. 