 If a participant expresses an interest in participating, and after time to read, consider and discuss the PIS in clinic, they will be provided with an appointment at the MSk Lab at Imperial College. At the start of the assessment the participant will be asked about their potential eligibility based on the pre-defined eligibility criteria and will be provided with a further opportunity to ask any questions about the study. If they are still interested in participating, the potential participant will be asked to complete three Consent Forms and they will be enrolled in the study. 