 An unbalanced randomization active: placebo of 5:3 ratio in Cohort I 430 CAD106 :260 Placebo and 3:2 ratio in Cohort II 390 CNP520 : 260 Placebo will be applied. Randomization will be stratified by age group 60-64 years, 65-75 years and region North AmericaOther , Europe. 