 Gait disabilities affect personal activities and quality of life of progressive multiple sclerosis MS patients. A robot-driven gait orthosis allowing a more effective support of walking movements and imitation of a nearly normal gait pattern during treadmill training at a higher speed has been developed and recently introduced in clinical settings. However, until now few studies evaluated the effects of Robot-Assisted Gait Training RAGT in a group of stroke, spinal cord injury and MS subjects. 