 9. Statistical Analysis: A chi-squared test will be used to compare the proportion of patients with complete reversal of HE after 5 days in LOLA treatment and placebo groups. A 95 confidence interval for the difference in proportions will also be calculated. A Chi-squared test will then be used to compare the HE grading at 5 days between the groups. Blood ammonia levels will be compared between groups using an independent samples t-test; while length of hospital stay is not expected to be normally distributed and therefore will be compared using a non-parametric Mann-Whitney test. All statistical tests will be 2-sided and using a 5 significance level. 