 Analysis of these data up until late 2012, show a predominance of non-vaccine serotypes in early infancy, followed by a shift towards vaccine serotypes, particularly serotype 1, in late infancy and into childhood. The finding of serotypes 1, 5 and, 14 to be the most frequent disease causing isolates is in keeping with data summarized in the Global Serotype Project which demonstrated serotype disease order of frequency in low-income countries was 14, 5, 1, 6B, 19F, 23F and 6A. The age distribution of vaccine type disease reinforces the importance of initiating vaccine coverage early in infancy such that early boosting at 9 months may be performed to maintain coverage into early childhood. 