 - History of clinically significant or uncontrolled cardiac disease including: a. history of a clinically significant ventricular arrhythmia such as ventricular tachycardia, ventricular fibrillation, or Torsades de pointes b. diagnosed or suspected congenital or acquired prolonged QT syndrome c. history of prolonged QTc d. unexplained syncope e. history of or active congestive heart failure f. myocardial infarction within 12 months. g. Uncontrolled angina or hypertension within 3 months. 