 This is a Phase I, non-randomized, open label study in healthy, non-pregnant, HIV negative women, who are not at risk of pregnancy, and are at low risk for STIs sexually transmitted infections. Participants will be assigned to use one of four placebo products: IVR intravaginal ring approximately 20 participants, and vaginal insert, film or HEC universal placebo gel approximately 10 participants each. Each woman will provide pre-product use vaginal swabs. Participants assigned to vaginal insert, film or gel will use products with and without timed intercourse with their male partner for a total of two doses of the product, will provide vaginal swabs post product use, and will be seen over 4 visits. 