 Post-dural puncture headache PDPH is the most common complication following lumbar puncture LP. The frequency varies widely depending on a number of factors, among which patient characteristics, case ascertainment, gauge and type of needle used are of significant importance. In 2001, Strupp et al. showed that over 12 of 115 patients who were subjected to diagnostic lumbar puncture with a 22 gg 0.7 mm atraumatic needle suffered post-dural puncture headache, while over 24 of 115 who were given a lumbar puncture with a 22 gg traumatic needle suffered a headache. This finding provided the basis for an American recommendation to use a 22 gg atraumatic needle for diagnostic lumbar puncture. A later study with 58 patients has shown an even greater difference 36 versus 3 post-dural puncture headache when an atraumatic needle is used. Despite these findings, European Neurologist continue to hold on to the cutting needle. Here the investigators propose a prospective randomized study design with double masking; neither patient nor evaluator of PDPH aware of the needle design used, and with an active ascertainment of the occurrence of PDPH in accordance with updated headache classification guidelines. The investigators also intend to investigate whether specific neuroinflammatory substances and metabolites different outcome variables in the cerebrospinal fluid CSF will affect the explanatory variable. 