 Patients were divided into 2 groups based on whether aflibercept was later used as a rescue therapy. Group 1 received bevacizumab and ranibizumab only. Group 2 received bevacizumab, ranibizumab, and later aflibercept rescue therapy. Outcome measures include BCVA at 1 year, 2 years, 3 years and 4 years of follow up, and the average number of injections per year. 