 Timing: The study will last 3 years. The first eigth months will be spent for recruitment and randomization. The follow-up will last 2 years. Analysis of data will be performed ad interim, as soon as the last recruited patient completes the intermediate evaluation after one year of follow-up. Final main analysis will be performed right after the conclusion of follow-up of the last recruited patient. A number of analysis concerning secondary end-points and including every ancillary study that might be proposed from the Steering Committee or the participating Hypertension Specialist Centres, will be implemented thereafter. 