 Therefore, it would be of vital importance to have needles able to provide at the same time material for ROSE and histological core biopsy specimens to allow for further analyses, i.e. immunohistochemistry and molecular analysis. The availability of such needles would determine the centers with an established ROSE service to continue to use it and would also increase the chances that the patient will leave the service with a diagnosis and will have available additional material, so much needed in difficult cases or, in the near future, necessary to perform molecular studies in order to drive treatments. On the other hand in centers with no ROSE availability, needles with an accuracy not inferior to the one obtainable with ROSE will help overcome the limitations of cytology and ROSE and will facilitate the widespread utilization of EUS in the community and throughout the world. 