 All eyes included in this study received an initial loading dose of 3 monthly intravitreal injections of either ranibizumab andor bevacizumab. Afterwards, the treatment was made on a loose treat and extend protocol based on funduscopic examination, OCT findings and BCVA. The loose treat and extend protocol is as follows: if under examination there is stabilization of macular edema and resolution of subretinal fluid by OCT, plus no retinal hemorrhage by biomicroscopy with 90D lens and a stabilized BCVA for 2 successive visits, the next treatment and follow up were extended by 1 month. If the examination showed any signs of recurrence and the deterioration of VA equal or more than 1 line, the treatment injection interval was then shortened by 1 month. Most, but not all, of our patients followed the above loose treat and extend strategy since some patients would insist on following up and treatment with less frequency in spite of disease activity. Generally speaking, the patients follow up interval and dosing schedule are made to be equal to or less frequent than a bi-monthly basis after 1 year, even though there are signs of neovascular activity; either because of the economic burden, or the fear of the surgical procedures of intravitreal injection by the patients. Aflibercept was considered when the patient developed persistent subretinal fluid, or needed more frequent injections than a bi-monthly dosing. Patients had BCVA measured, along with funduscopic examination with 90 D lens and OCT imaging with Spectralis-OCT Heidelberg Engineering, Heidelberg, Germany at each visit. 