 Non-celiac gluten sensitivity NCGS or wheat sensitivity NCWS is included in the spectrum of gluten-related disorders. No data are available on the prevalence of oral lesions in NCWS. Our study aims to evaluate the prevalence of oral lesions in NCWS patients and search for correlations with other clinical characteristics. This prospective observation study will include 90 NCWS patients with irritable bowel syndrome IBS- like symptoms, 90 IBS and 90 celiac controls. Patients will be recruited at the Internal Medicine and at the Gastroenterology Units of the University of Palermo. Elimination diet and double-blind placebo controlled DBPC wheat challenge proved the NCWS diagnosis. All subjects underwent oral examination to assess the presence or not of oral soft and hard tissue lesions potentially associated to NCWS and CD. 