 Participating subjects will be asked to take part in an optional correlative study to provide previously archived diagnostic or therapeutic tumor samples obtained during the course of their routine medical care for their cancer of the headneck. The optional tissue repository project is Duke University Health System DUHS Institutional Review Board IRB approved eIRB 11138 Tissue Acquisition Protocol for Analysis of Effects of Novel Chemotherapeutic Compounds. Subjects will be asked to sign a separate consent form to participate in the tissue collection study. 