 Children aged 0.5-10 years presenting at health centres with fever or history of fever and other symptoms suggestive of malaria will be screened; children found to have uncomplicated Plasmodium falciparum malaria will be randomized to receive treatment with ASAQ, SPAQ or SPCQ. A drug dispenser will supervise the first dose of medication and subsequent doses will be given to the childs parent to be administered at home, unsupervised by the study team. Patients will be visited at home three days later. Unused medication will be counted and the mother will be asked about the number of doses the child received and any side effects. Children will be seen again 2 and 4 weeks after treatment to collect finger prick samples for packed cell volume PCV and malaria microscopy. The primary endpoint is clinical failure by day 28. Analysis will be by intention to treat. 