 - Clinical T2-T4c, any N, M0 invasive ER Allred Score of 6-8 and HER2 negative 0 or 1 by IHC or FISH negative for amplification breast cancer, by AJCC 7th edition clinical staging, with the goal being surgery to completely excise the tumor in the breast and the lymph node. Note: Patients with invasive ER Allred Score of 6-8 HER2- breast cancer or DCIS in the contralateral breast the patient are eligible 