 SandRA software sends every 2 to 6 weeks automatically an SMS to a patients cell phone, and the patient answers by one push on keyboard. The patients answers are recorded in SandRA and automatically analysed. If answers indicate non-adherence, adverse events, or missed target, the system automatically sends SMS: Your nurse will call you within 2 work days, and the nurse gets an alarm by e-mail. If needed, an extra visit is arranged for treatment adjustment. 