 8. History of the following within 6 months prior to first administration of investigational product: a myocardial infarction, severeunstable angina pectoris, coronaryperipheral artery bypass graft, New York Heart Association NYHA Class III-IV heart failure, uncontrolled hypertension, clinically significant cardiac dysrhythmia or clinically significant ECG abnormality, cerebrovascular accident, transient ischemic attack, or seizure disorder. 