 - Serum creatinine 1.5 mgdL or creatinine clearance 50 milliliters per minute mLmin. Creatinine clearance will be calculated based on Cockcroft-Gault method using the following formula: Male: 140age × weight ÷ serum creatinine × 72; Female: 0.85 × 140age × weight ÷ serum creatinine × 72. 