 6. Liver function abnormalities total bilirubin 1.5 times the upper limit of normal, ALT alanine aminotransferase AST Aspartate aminotransferase 2.5 times the upper limit of normal or hepatic involvement of ALT AST 5 times the upper limit of normal, renal dysfunction Creatinine 1.5 times the upper limit of normal, electrolyte abnormalities; 