 Significance and clinical relevance : The present study focuses on an important issue in the investigators society, namely HFPEF in the elderly population. This health problem has been largely ignored despite the fact that there is no recommended therapy. The investigators proposed study represents a paradigm shift in therapy. It is based on a new concept focusing on comorbidities that are considered to be predisposing factors to HFPEF in contrast to available trials that target only the heart. The investigators study therefore challenges the current clinical practice and may fill the knowledge gap in HFPEF. 