 In the treatment trials 29 and 29X, the population PK properties of rifapentine were characterized in 415 participants. Rifapentine oral clearance did not significantly change with weight. Rifapentine bioavailability decreased with greater rifapentine doses and the increase in exposure was less than dose-proportional. Median exposures at steady state of rifapentine AUC0-24 were 292, 474, and 579 μghmL, respectively, for 600, 900, and 1200 mg daily doses. Because rifapentine clearance was not weight-dependent, a level rifapentine treatment dose that is, a mg rather than a mgkg dose is recommended for adults. Rifapentine 1200 mg daily is incorporated into the Study 31 treatment trial protocol. Because food taken with rifapentine study doses significantly increased rifapentine exposure, it is recommended in Study 31 that a meal be taken prior to rifapentine study doses. 