 In a recently published a prospective outcome validation study of the age-adjusted cutoff in patients with a clinically suspected PE.13 The study included more than 3300 patients with suspected PE and showed that the three-month thromboembolic risk in patients with an nonhigh or unlikely clinical probability and a D-Dimer level between 500 microgL and the age-adjusted cutoff was of 0.3 95 CI: 0.1 5 to 1.7. These results were in line with the one found in patients with a D-dimer level below the usual cutoff of 500 microgL: 0.1 95 CI: 0.0 to 0.7. Moreover, in patients above 75 years the age-adjusted cutoff allowed to increase five-fold the number of patients in whom PE could be excluded without imaging test. 