 The overall goal of this protocol is to evaluate the safety, tolerability, pharmacokinetics PK and pharmacodynamics PD of escalating single oral doses of AEF0117 in healthy adult male and female subjects. This will be a single center study in healthy adult male and female subjects. The study design will be a double-blind, randomized, placebo-controlled, single period, parallel group, single dose escalation with AEF0117. 