 For outcome- As this is an observational study, residual confounding cannot be ruled out, and reporting of results will acknowledge this. For the outcome variables measured at multiple time points specifically patient-reported quality of life, measures at each time point will be described, and repeated measures models will be used to reduce the probability of type I errors. Imputation techniques will be used where data on quality of life or other outcome variables is missing. Propensity score analyses will also be considered if informative scores and adequate matching can be achieved. 