 Furthermore, flat and depressed lesions, which are more difficult to detect in white light colonoscopy, may represent over 25 of all pre-malignant lesions and may confer a higher risk for malignancy. Integration of molecular probes that home in to diseased tissues with high resolution imaging instruments could greatly improve the diagnostic accuracy for missed lesions of both polypoid and non-polypoid morphology, including the often fatal right-sided adenomas. 