 Recently, several companies have attempted to develop a new technology that measures continuous glucose. Some of these techniques are non-invasive while others are minimally invasive. Continuous glucose monitoring system CGMS employs four different approaches: transdermal, glucose electrode, micro-dialysis or open-flow micro perfusion. Currently, two are commercially available. The transdermal approach Glucowatch; Cygnus, CA, USA employs reverse iontophoresis by applying low voltage current to the skin surface causing interstitial fluid containing glucose to pass through the skin 12. Glucose is then measured by an oxidase reaction. This data also contains information about skin temperature and sweat that are all included in the calculation process. The MiniMed CGM System Sylmar, CA, USA is composed of a disposable subcutaneous glucose-sensing device and an electrode impregnated with glucose oxidase connected by a cable to a lightweight monitor which is worn over clothing or a belt 13. The system measures glucose levels every 10 seconds, based on the electrochemical detection of glucose by its reaction with glucose oxidase, and stores an average value every 5 minutes, for a total of 288 measurements per day. The glucose measurement is performed in subcutaneous tissue in which the interstitial glucose levels are in the range of 40-400 mgdl. The data are stored in the monitor for later downloading and reviewing on a personal computer. The patients are unaware of the results of the sensor measurements during the monitoring period. Glucose values obtained with CGMS have been shown to correlate with laboratory measurements of plasma glucose levels 14 and with home glucose meter values 15. 