 This is a randomized, open-label, multi-center, phase 2 study of RCHOP with or without VELCADE in adult patients with previously untreated non-Germinal B-Cell-like GCB Diffuse Large B-cell Lymphoma DLBCL. The study will determine whether the addition of VELCADE to RCHOP improves progression-free survival PFS in patients with non-GCB DLBCL. 