 - Eastern Cooperative Oncology Group ECOG performance status 2; Absolute leukocyte count 4000mm3, platelets 100,000mm3, hemoglobin 9.0 gdL; total bilirubin, aspartate amino transferase AST and alanine amino transferase ALT 1.5 the upper normal limit UNL, creatinine 1.2 mgdL or a calculated creatinine clearance of 60 mLmin. 