 All studies published to date addressing the role of systemic antibiotics and M3 removal have one or more major methodological flaws in study design characterized as :1 no or ambiguous definition of the outcome variable, 2 inadequate sample size, 3 non-uniformity of protocol design, 4 lack of randomization techniques and 5 poor-follow-up monitoring. Clearly, there is a need for a definitive, rigorous, well-designed placebo-controlled randomized clinical trial to ascertain the efficacy of systemic antibiotics in preventing postoperative inflammatory complications after M3 removal. 