 Chanarin Dorfman syndrome is a rare genetic disorder of fat lipid metabolism. It is characterized by ichthyosis, myopathy, and abnormal white blood cells with small spaces vacuoles filled with lipids. Additional symptoms may occur including hearing loss, vision abnormalities, hepatomegaly and a condition in which fat accumulates in the liver liver steatosis or fatty liver. Cognitive decline may occur in some cases. Chanarin Dorfman syndrome is inherited as an autosomal recessive trait. 