 The purpose of this registry is to collect additional information regarding the side effects and effectiveness of BENLYSTA belimumab when given with other lupus medicines to adults with active systemic lupus erythematosus SLE. Information will be collected on serious events that are not that common or may only be seen with long-term treatment. These events include death, cancers, serious infections and other infections of interest, and serious mental health problems. Information on the effectiveness of BENLYSTA will also be collected. 