 This is a cross-sectional observations or measurements made at a single point in time, usually at participant enrollment, multi-center conducted in more than one center, and comparative study of topiramate monotherapy in female participants with epilepsy. Female participants must have received either topiramate, carbamazepine, or valproic acid monotherapy for more than one year for the treatment of epilepsy. Blood samples will be obtained from fasting participants to investigate the effect of study drug on the bone and mineral metabolism markers, and bone density compared to healthy participants and comparative group carbamazepine and valproic acid monotherapy. Bone mineral density will be measured from the participants lumbar spine or femur. A survey of food intake and physical activity for the participants will be performed using a standardized validated detailed questionnaire. The post-study visit or follow up phone contact will be performed for the occurrence of serious adverse events SAE for safety evaluation. Participants safety will be monitored throughout the study. 