 Hepatosplenomegaly and protrusion of the abdomen can cause umbilical hernia, a condition in which the contents of the stomach may push through an abnormal opening or tear in the abdominal wall near the bellybutton. Additional symptoms may also occur in Wolman disease including yellowing of the skin, mucous membranes and whites of the eyes jaundice, a persistent low-grade fever, and poor muscle tone hypotonia. Infants may exhibit delays in the development of motor skills. 