 Patients are recruited at diagnosis or at relapse of ATLL-HR in French Caribbean islands and Guyana. They all receive Zidovudine and Pegylated Interferon ZPI. For patients younger than 65 years old, an allogeneic donor is searching out. Patients included at relapse and with lymphoma clinico-biological subtype also receive chemotherapy CT. Responses are assessed during ZPI-CT and eligible patients depending on age, comorbidities and response criteria receive allogeneic transplant. Patient follow-up is planned for 3 years old 