 - Prior chemotherapy with combination of capecitabine or 5-flourouracil 5-FU and temozolomide or dacarbazine DTIC will be excluded; patients can have had prior therapies up to 3 prior chemotherapy regimens such as streptozocin, anthracyclines, irinotecan, etoposide, or a platinum agent including single agent capecitabine or 5FU or temozolomide or DTIC. 