 - adequate lab. findings neutrophil 1.5 x 109L platelet 75 x 109L hemoglobin 9.0 gdL bilirubin 1.5 x upper normal limit AST, ALT 2.5 x upper normal limit Alkaline phosphatase 2.5 x upper normal limit if liver metastasis, 5 x upper normal limit serum creatinine 1.0 x upper normal limit if serum creatinine 1.0 x upper normal limit, creatinine clearance 60 mLmin 