 - Symptomatic metastatic brain or meningeal tumors unless the patient is 6 months from definitive therapy, has a negative imaging study within 4 weeks of study entry and is clinically stable with respect to this brain tumour site at the time of study entry. Also the patient must not be undergoing acute steroid therapy or taper chronic steroid therapy is acceptable provided that the dose is stable for one month prior to and following screening radiographic studies head CT or MRI at screening always required 