 Twenty-seven breast cancer women without heart failure, underwent CMR imaging 3T-Achieva, Philips before and 3 times serially after 4-cycles of adjuvant DOX 60mgm2. CMR assessed left ventricular LV ejection fraction EF, T1 mapping pre and post gadolinium and late gadolinium enhancement imaging. Biomarkers were obtained before and 72 hours after each DOX-cycle. 