 - Medically documented history of or active major depressive episode, bipolar disorder I or II, obsessive-compulsive disorder, schizophrenia, a history of suicidal attempt or ideation, or homicidal ideation immediate risk of doing harm to others or patients with active severe personality disorders defined according to Diagnostic and Statistical Manual of Mental Disorders DSM-IV are not eligible; NOTE: for patients with psychotropic treatments ongoing at baseline, the dose and the schedule should not be modified within the previous 6 weeks prior to start of study drug 