 1. Determine the test performance PPV, specificity of SNP based NIPT for detecting other microdeletion syndromes available in the Panorama microdeletion panel e.g., 1p36 deletion, Cri-du-chat, Prader-Willi, and Angelman individually and all combined including 22q11.2. Given the incidences of 1:5000, the confidence intervals are expected to be large. 