 Data reviewed by Etkin et al. 2011 suggest a controlled conscious top-down regulation, like emotional conflict regulation, uses ventral ACC and mPFC areas to inhibit negative emotional processing in the amygdala, thus dampening task interference. The ventral ACC and mPFC might thus perform a generic negative emotion inhibitory function that can be recruited by other regions e.g. dorsal ACC and mPFC and lateral PFC when there is a need to suppress limbic reactivity. One might speculate that a dysfunction in this circuit might contribute to a PTSD dysfunction in regulating negative emotional conflict. Unable to regulate and suppress emotional arousal related to trauma relevant information, the PTSD affected individual might choose to avoid it all together. The limbic reactivity might contribute to hyper vigilant responses, and affect memory processes leading to intrusion, as well. In short, dysfunction in the ventral medial PFC structures and their connections might contribute to all symptom clusters. 