 Blood will be drawn on the day of admission before initiating therapy for in vitro drug sensitivity testing and for PCR markers of drug resistance and to distinguish recrudescence from reinfection by genotyping. Malaria smears will be prepared twice daily until parasite clearance and on Days 7, 14, 21, 28, 35, and 42 or whenever symptoms consistent with malaria appear. Plasma samples for determining drug levels will be obtained on the first and last day of therapy. Study participation for each individual will be 42 days. 