 Sample Size Calculations We aim to recruit 40 patients into each group total n120. The sample size calculation for the study was conducted based on the within group standard deviation of 12.9 this was the standard deviation for baseline to final study visit in our SBrTMS study and between group difference of 5.0 points. With an alpha of 0.05 the study will have a power of 0.87 to detect a difference in end scores between the 3 groups calculation in PASS 8.0. 