 9. History of arrhythmia multifocal premature ventricular contractions PVCs, bigeminy, trigeminy, ventricular tachycardia, or uncontrolled atrial fibrillation which is symptomatic or requires treatment CTCAE grade 3 or asymptomatic sustained ventricular tachycardia. Atrial fibrillation, controlled on medication is not excluded 