 Preterm birth, its causes, prevention, complications and ramifications persist as an important focus of obstetrical research. In the United States 11.8 of all live births occur prior to 37 weeks gestation. As many as 45 of these deliveries will have been proceeded by preterm labor with intact membranes.2 Both preterm labor and preterm premature rupture of membranes have both been associated with evidence intrauterine infection. While antibiotic treatment in conservative management of preterm PROM remote from term has been shown to significantly prolong pregnancy and reduce infant morbidity, 16 data regarding the effectiveness of antibiotics for pregnancy prolongation in preterm labor are inconsistent. 3-15 Currently, narrow spectrum antibiotics penicillin or clindamycin are given prior to delivery to reduce the risk of neonatal Group B Beta Streptococcus GBS sepsis, however broad spectrum antibiotic treatment of women with preterm labor for pregnancy prolongation is not recommended. 