 - No systemic treatment, within 14 days before the first dose of ibrutinib with moderate or strong inhibitors of CYP3A Strong Inhibitors: ketoconazole, itraconazole, voriconazole, posaconazole, clarithromycin, and telithromycin; Moderate Inhibitors: fluconazole, darunavir, erythromycin, diltiazem, atazanavir, aprepitant, amprenavir, fosamprenavir, crizotinib, imatinib, verapamil, ciprofloxacin, grapefruit juice products, and Seville oranges or strong CYP3A inducers for ibrutinib and ixazomib carbamazepine, rifampin, phenytoin, St. Johns wort. 