 A population based randomised trial of FS from Norway achieved a participation rate of 67 but a randomised study from The Netherlands achieved an uptake of 32.4 for FS compared with 49.5 and 61.5 for gFOBT and FIT respectively. In addition, there is evidence that participants perceive the personal burden of FS to be greater than that of either type of faecal testing. On the other hand, a study from Italy found a similar participation rate or FIT and FS, although both were low at 32 of those invited. Two small studies conducted in the London area observed an uptake of screening FS of around 50 but a similar study carried out in Tayside, Scotland achieved an uptake of only 24. It is not clear why there should be such discrepancies in uptake of FS, but both cultural issues and differences in levels of deprivation are likely to be important. 