 Background: Heparin is an anticoagulant commonly used in the neonatal population as a means to prevent catheter related occlusion and malfunction by thrombosis clot. Given the recent overdoses of infants using heparin, there is concern as to whether heparin should be used in peripherally inserted central venous catheters PICC. Scientific evidence comparing the duration of use of heparin versus no heparin in PICCs is conflicting. 