 16. Cardiac conditions as follows: i. Mean QT interval corrected for heart rate QTc 450 ms calculated from 3 ECGs using Fredericias formula QTcF or other factors that increase the risk of QT prolongation. ii. Uncontrolled hypertension BP 15095 despite optimal medical therapy. iii. Acute coronary syndrome within 6 months prior to starting treatment. iv. Uncontrolled Angina - Canadian Cardiovascular Society grade II-IV despite medical therapy. v. Symptomatic heart failure NYHA Class II-IV, prior or current cardiomyopathy, or severe valvular heart disease. - Criteria continued in 17 