 3. Contraindications according to the vandetanib SmPC not applicable for patients who do not receive vandetanib: a Patients with a QT interval corrected for heart rate QTc interval over 480 msec: i Congenital long QT syndrome ii Concomitant use of vandetanib with the following medicinal products known to also prolong the QT interval and or induce Torsades de pointes: Arsenic, cisapride, erythromycin intravenous IV, toremifene, mizolastine, moxifloxacin, Class I A and III antiarrhythmics b Currently pregnant or breast feeding c Hypersensitivity to the active substance or to any of the excipients d Severe renal impairment: creatinine clearance 30 mlminute calculated by Cockcroft-Gault formula. See Appendix D. e Serum bilirubin greater than 1.5 x the upper limit of reference range ULRR f Potassium, magnesium or calcium outside the normal laboratory range 