 The prognosis of chronic hepatitis C virus HCVinfeciton varies from minimal progressive disease to cirrhosis or hepatocellular carcinoma. Host genetic factors contribute to disease severity. It is known that cytokine gene including tumor necrosis factor-alpha TNF-alpha and interleukin-10 IL-10 polymorphism affect disease prognosis.This study aims to assess the effect of TNF-alpha and IL-10, and their interaction,on prognosis of HCV-related chronic liver disease 