 Research on estimation and measurement of renal function has been greatly stimulated by the international concept of chronic kidney disease CKD and its classification into stages of severity based on the level of glomerular filtration rate GFR National Kidney Foundation KDOQI and ANAES in 2002, KDIGO conference in 2005, and by the development of recommendations for clinical practice according to this stages. Many efforts have focused on the validation of new formula to estimate GFR from endogenous markers. Nevertheless, the performance of these formula is limited by a large inter individual variability, that requires in many cases the use of GFR measurement using exogenous tracers extreme anthropometric characteristics, abnormal production of endogenous tracers, potential kidney donors, dose adjustment, nephrotoxicity monitoring.... The use of GFR measurement is burdened by a lack of availability due to methodological, biological and regulatory for radioactive tracers constraints. Thats why a need exists for new validated tracers that will be more accessible and easier to use. Moreover, there are differences between the measurement techniques: single injection of the tracer or concentration equilibrium obtained by continuous infusion; plasma or urinary clearance. 