 - High risk of tumor recurrence as defined as one of the following: 1 the largest tumor diameter greater than 10.0 cm measured by a pathologist, with any mitotic count; 2 mitotic count over 10 mitoses per 50 high power fields HPFs with any tumor size; the largest tumor diameter larger than 5.0 cm and the mitotic count is over 550 HPFs; 4 tumor spillage into the abdominal cavity at surgery or tumor rupture. No residual tumors must be present at laparotomy, or in postoperative CT or MRI examinations. Patients who have microscopically infiltrated margins or suspected microscopical infiltration, R1 are also allowed to enter study. 