 - Female subjects must be of non childbearing potential including pre-menopausal females with documented hysterectomy or double oophorectomy or tubal ligation or postmenopausal defined as 12 months of spontaneous amenorrhea or 6 months of spontaneous amenorrhea with serum FSH levels 40 mIUmL and estradiol 40 pgml 140 pmolL or 6 weeks postsurgical bilateral oophorectomy with or without hysterectomy. Hormone replacement therapy HRT is permitted for post-menopausal females. 