 - Histologically confirmed diagnosis of B-cell lymphoma DLBCL, MCL, FL, MZL, LPLWM, SLL or PCNSL or CLL Matutes score 4 requiring treatment that is recurrent after at least one prior therapy for which no potentially curative therapy nor better treatment option is available. Specifically, the patient should have received all treatments considered to be standards of care, including stem cell transplantation when appropriate, if patient eligible, and agents known to have significant clinical efficacy in their disease.Patient must be eligible for tumor biopsy. Biopsy at relapse is mandatory for all patients except for PCNSL optional and should provide enough tumor tissue for biological tests paraffin-embedded and frozen or RNAlater-conserved tissue. 