 This is a prospective, multicenter, randomized, open-label controlled Phase 1b2a study designed to evaluate the safety and preliminary efficacy of MPCs combined with MasterGraft Granules when compared to use of autologous bone graft in the posterolateral fusion site in subjects requiring interbody fusion in combination with instrumented 1 or 2 level PLF procedure. All subjects in this study will undergo a 1 or 2-level 2 or 3 vertebrae interbody fusion without the use of the investigational product. 