 40 Patients will be taking part in a single arm open label research study - which means that everyone in the research study will receive the investigational treatment OncoSilTM, plus their prescribed standard chemotherapy regimen which will be either; FOLFIRINOX FOLFIRINOX is the name of a combination of chemotherapy drugs used to treat advanced cancer of the pancreas or gemcitabine nab-paclitaxel Abraxane. 