 - Patients receiving chronic treatment with steroids or another immunosuppressive agent; note: topical applications e.g. rash, inhaled sprays e.g. obstructive airway diseases, eye drops or local injections e.g. intra-articular are allowed; patients with previously treated brain metastases, who are on stable low dose corticosteroids treatment e.g. dexamethasone 2 mgday, prednisolone 10 mgday for at least 14 days before start of study treatment are eligible; premedication dexamethasone for pemetrexed is allowed 