 The past several years have witnessed significant advancement in the understanding of potential mechanisms of secondary injury after severe TBI. This is important work as secondary injury after severe TBI is thought to significantly increase the severity of the initial injury and this type of injury is thought to be open to interventions to attenuate the subsequent injury severity. Among the putative mechanisms of secondary injury after severe TBI, it was recently demonstrated that there is a relationship between CSD events and worse outcomes after severe TBI. Therefore, a more thorough understanding of the factors that influence the initiation and frequency of CSDs after TBI is warranted in order to develop therapeutic strategies to reduce or block these events from occurring. 