 4. A history of cerebrovascular accident CVA or transient ischemic attack TIA within the past 6 months; or a history of intracranial tumor, aneurysm or arteriovenous malformations; or a history of active peptic ulcer or active gastrointestinal GI bleeding within the past 2 months; or planned major procedure within 6 weeks; or known platelet count 100,000 mm3 or Hb 10 gdL 