 TNSS, nasal sniff pressures, nasosorption measures and gene expression data from the nasal scrapes will each be plotted against time, with a separate plot for each subject and measure, and with LPS dose and placebo represented by separate lines on the plots. Summary statistics e.g. mean - 95 confidence intervals or median and interquartile range for nasal lavage and gene expression data will be plotted by dose against time. 