 Participants will be treated with ADT plus chemotherapy for three, four, or five 8-week cycles 12, 18, or 24 months. The number of cycles of chemotherapy they receive and the number of months they receive ADT will be based on their disease. The current standard treatment is ADT and chemotherapy. What differs in this research study is the cycling and combination of chemotherapy drugs chosen. The drugs chosen for this study have fewer side effects and are believed to provide maximum benefit. 