 - e. Subject has a clinically significant abnormal 12-lead ECG that may jeopardize the subjects ability to complete the study or a screening 12-lead ECG demonstrating any one of the following: heart rate 100 beats per minute, QRS 120 ms, QT interval corrected for heart rate using Fridericias formula QTcF 450 ms males, QTcF 470 ms females, or PR 220 ms. 