 6. Adequate organ function as defined: absolute neutrophil count 1500mL; platelets 100,000mL; hemoglobin 9 gdL or 5.6mmolL; serum creatinine 1.5 X ULN or GFR 60 mlmin for patients with creatinine 1.5xULN; serum total bilirubin 1.5 X ULN direct bilirubin ULN if total bili 1.5xULN; ASTSGOT and ALTSGPT 2.5X ULN or 5xULN if liver mets; INR or PT 1.5xULN unless subject is receiving anticoagulant therapy as long as PT or PTT is within therapeutic range of intended use of anticoagulants; aPTT 1.5xULN unless subject is receiving anticoagulant therapy as long as PT or PTT is within therapeutic range of intended use of anticoagulants 