 - Use of prescription or nonprescription drugs and dietary supplements within 7 days or 5 half lives whichever is longer prior to the first dose of study medication. As an exception, acetaminophenparacetamol may be used at doses of 1 gday. Limited use of non-prescription medications that are not believed to affect subject safety or the overall results of the study may be permitted on a case-by-case basis following approval by the sponsor. 