 This is a randomized parallel-group single centre study. All the patients enrolled will have an acute, closed Weber C-type ankle fracture. The ankle syndesmosis will be fixed using the new medical device antibiotic containing bioabsorbable screw or the routinely used device metal screw. The investigational antibiotic containing bioabsorbable screw for ankle syndesmosis repair the thread diameter 4.5 mm will be made of bioabsorbable polylactide-co-glycolide PLGA 80:20 and ciprofloxacin, which is a bactericidal antibiotic. The main purpose of the screw is to prevent syndesmosis widening after Weber C-type of ankle fracture. The secondary function of the screw is to reduce the risk for colonization of the implant with bacteria and subsequently prevent biomaterial-related infection. In the control group, a stainless steel screw will be used. All patients will receive the standard of care for concomitant fractures and other injuries of the ankle. 