 - Have signs or a history of significant rhinitis or rhinorrhea constant or chronic, nasal polyps, mucosal lesions of the nostril, postnasal drip of any etiology constant or chronic, nasal ulcers, septal perforation or deviation, any nasal surgery, anosmia, nasal piercings, or frequent nosebleeds or other nasal pathology, that is sufficient to interfere with IN drug delivery. 