 BACKGROUND: Central venous catheters CVC are the only option when hemodialysis is needed for patients without definitive vascular access. However, CVC use is associated with complications such as infection, thrombosis, and dysfunction, leading to higher mortality and expenditures. The aim of this study was to compare the effectiveness of 30 trisodium citrate TSC30 with heparin as CVC lock solution in preventing catheter-related bloodstream infections CRBSI and dysfunction in hemodialysis patients. METHODS: Randomized, double-blind controlled trial comparing the event-free survival of non-tunneled CVC locked with heparin or TSC30 in adult hemodialysis patients. 