 Patients scheduled for elective craniotomy are randomized to receive Dex 1γKg over 10 minutes following by continuous infusion of Dex 0.7γKg group D or esmolol 500mcgKg over 5 min following by continuous infusion of 300mcgKgmin group E. Patients in both groups are subjected to a standardized anesthesia comprising of induction with propofol, fentanyl, rocuronium, and maintained with Oxygen-air: 11, sevoflurane and bolus fentanyl in order to access the same level of anesthesia BIS 40-50. The hemodynamic variables at various stages of surgery HR-heart rate, MAP-Mean arterial pressure and recovery characteristics are also recorded. It is also performed monitoring of cerebral oximetry INVOS. 