 - Subjects will be included if they meet criteria for mild and moderate COPD as defined by the American Thoracic Society and European Respiratory Society position paper. Mild COPD will be defined as a postbronchodilator 2 puffs of albuterol FEV1FVC ratio of 0.7 and a predicted FEV1 of 80. Moderate COPD will be defined as a postbronchodilator FEV1FVC ratio of 0.7 and a predicted FEV1 50-80. A response to bronchodilators is defined as an increase of 12 or 200cc in FEV1 from baseline after inhalation of 2 puffs of albuterol. Both subjects with and without a response to bronchodilators will be included in the study. 