 - Participants with less than 50 percent of predicted forced expiratory volume FEV-1 or less than 50 of predicted diffusing capacity for carbon monoxide DLCO corrected for hemoglobin concentration and alveolar volume. Note: Participants with no prior history of pulmonary illness are not required to have pulmonary function test PFTs. FEV1 will be assessed after bronchodilator therapy. 