 End-of-dose fluctuations e. g. wearing-off are defined as a recurrence of motor and non-motor Parkinsons Disease PD symptoms that precedes a scheduled dose and improves with the next dose of anti-parkinsonian medication. Azilect is approved and recommended for therapy of wearing-off-End-of-dose fluctuations and improves motor fluctuations significantly in combination therapy with L-dopa and other parkinsonian medication. 