 Introduction Diabetes is a major risk factor for coronary artery disease and diabetic patients are considered CAD equivalent in the absence of CAD1. The presence of CAD and diabetes makes the patient at a much higher risk for future morbidity and mortality. Moreover, percutaneous coronary intervention PCI in diabetics is associated with a higher risk of major adverse cardiac events MACE. Several studies have also suggested that the release of cardiac biomarkers during PCI procedures have an independent predictability of a worse prognosis in terms of both morbidity and death. Furthermore, previous investigations suggested that glycoprotein IIbIIIa inhibitors GPI should be used routinely in all diabetics undergoing PCI due to their higher propensity of developing a hyper aggregatory status during such procedures that puts them at a higher risk of developing myocardial injury and subsequent cardiac biomarkers release. However, recent investigation suggested that high dose clopidogrel 600 mg given at least 4 hours prior to intervention is as protective as Abciximab in low risk patients undergoing elective PCI 2. Thus, high dose clopidogrel preloading without GPI has become the standard for low risk patients undergoing elective PCI. There is limited data in the literature to suggest that routine administration of GPI prior to PCI in diabetic patients with a high dose preloading with clopidogrel is actually beneficial. That is why this trial is being undertaken. 