 - Patients with histologically proven cutaneous melanoma at one of the following American Joint Committee on Cancer stages : Regional metastatic disease any T; N2c or N3; M0, no amenable to curative treatment by surgery or isolated limb perfusion.Distant metastatic disease any T; any N; M1a, M1b or M1c.except uncontrolled brain metastasis and except Lactate dehydrogenase 1.5 upper normal value 