 Our multicentric the 3 CISIH from Marseille, Nice and Montpellier 3 year- long study will analyse 50 HIV1-infected naive patients A group, apparied to 50 age- and sex-matched seronegative control subjects recruited by CIC-UPCET of Marseille and 100 HIV1-infected patients in first line of antiretroviral therapy for at least 12 months B group. Patients of group A and B will be recruited in the 3 clinical unit. The HIV1- infected patients will be evaluated four times, at baseline, then every 12 months during 3 years. In case of initiation or changing of antiretroviral therapy, patients will be evaluated once more. Control subjects will be only evaluated at baseline. 