 - Participants with any history of thrombosis, inherited or acquired thrombophilia, bleeding diathesis or coagulopathy including any abnormal bleeding or blood dyscrasias, hematologic disease, clinically significant hemorrhagic disorder, excessive bruising, bleeding from nose or gums or known disorders with increased bleeding risk eg, acute gastritis, acute peptic ulcer, serious bleeding including gastrointestinal bleeding requiring hospitalization, intracranial bleeding of any type, or uncontrollable postoperative bleeding 