 13. Cont. from 12. Long QT syndrome or family history of idiopathic sudden death or congenital long QT syndrome, or any of the following: a. Risk factors for Torsades de Pointe TdP including uncorrected hypokalemia or hypomagnesemia, history of cardiac failure, or history of clinically significantsymptomatic bradycardia. b.Concomitant use of medications with a known risk to prolong the QT interval andor known to cause Torsades de Pointe that cannot be discontinued within 5 half-lives or 7 days prior to starting study drug or replaced by safe alternative medication. c. Inability to determine the QT interval on screening QTcF, using Fridericias correction. d. Systolic blood pressure SBP 160 mmHg or 90mmHg at screening. 