 Period 2 Treatment Period will consist of 4 visits Visits 3A-3D two weeks apart 142 days. Subjects who comply with the inclusionexclusion criteria will be assigned to one of 5 dose groups. The first dose group will receive 4 administrations of ToleroMune Ragweed. Successive dose groups will increasing doses given as 4 administrations of ToleroMune Ragweed, provided the first administration of the previous dose was safe and well tolerated. 