 This study determines whether NF-кB dependent proinflammatory state found in type 2 diabetes yield to a higher RAGE activation in the mesenchymal stem cell, as well as the effects of the proinflammation on osteoblast differentiation impairment and cellular apoptosis in type 2 diabetic patients. This study will compare non-diabetic control subjects and type 2 diabetic patients with metformin monotherapy failure in the aspect of 1 serum markers for NF-кB dependent proinflammatory state and its intracellular signals, 2 osteogenic differentiation and apoptosis of the mesenchymal stem cells, and 3 serum AGE, RAGE and cellular RAGE activation. 