 - Patients with prior contraindications for the use of irinotecan therapy-this would include chronic inflammatory bowel disease and or bowel obstruction, history of severe hypersensitivity reactions to irinotecan hypochloride, trihydrate, lactic acid or to any of the excipients of Camptostar, severe bone marrow failure, history of Gilbert Syndrome or concomitant use with St. Johns Wort 