 1. Male or female adolescents between the ages of 12-18 years at the time of enrollment with clinically significant symptoms of anxiety or depression at baseline. Evidence of clinically significant symptoms will be defined as a Clinical Severity Rating CSR greater than or equal to 4 on any DSM-5 defined anxiety disorder e.g., generalized anxiety disorder, social phobia, selective mutism, separation anxiety disorder or depressive disorder e.g., major depressive disorder, persistent depressive disorder, or an adjustment disorder with depressed mood, anxiety, or mixed anxiety and depressed mood. 