 6. Patients who have received thoracic radiotherapy to lung fields 4 weeks prior to starting the study treatment or patients who have not recovered from radiotherapy-related toxicities. For all other anatomic sites including radiotherapy to thoracic vertebrae and ribs radiotherapy 2 weeks prior to starting the LDK378 treatment or have not recovered from radiotherapy-related toxicities. Palliative radiotherapy for bone lesions 2 weeks prior to starting LDK378 treatment is allowed. 