 - Measurable Disease: Lesions that can be accurately measured in at least one dimension longest diameter to be recorded as 20 mm with conventional techniques. The same method of assessment and the same technique should be used to characterize each identified and reported lesion at baseline and during follow up. Image based evaluation is preferred to evaluation by clinical examination. Lesions that are considered to be unmeasurable include the following: bone lesions, leptomeningeal disease, ascites and pleuralpericardial disease. 