 - Used any of the following treatments within the indicated washout period before the baseline visit: 12 weeks or 5 half-lives whichever is longer - biologic agents eg, 18 weeks for omalizumab; 8 weeks - cyclosporin, methotrexate, azathioprine, or other systemic immunosuppressive or immunomodulating agents eg, mycophenolate or tacrolimus; 4 weeks - systemic corticosteroids or adrenocorticotropic hormone analogs; 2 weeks - topical treatments: corticosteroids, calcineurin inhibitors, or coal tar on the body; 2 weeks - immunizations; sedating antihistamines non sedating antihistamines are permitted; 1 week - topical antibiotics, antibacterial cleansing body washsoap or diluted sodium hypochlorite bleach baths. 