 - Use of immunosuppressant drugs in the past 3 months and or at time of treatment such as oral glucocorticoids, cytostatic, antibodies, drug acting on immunophilins, interferon, opioids, Tumor Necrosis Factor TNF binding proteins, mycofenolate mofetil MMF, biologic agents. inhalation corticosteroids nasal corticosteroids are permitted. 