 All individuals underwent a full-mouth periodontal examination, which included probing pocket depth PPD, clinical attachment level CAL, plaque index PI, gingival index GI, bleeding on probing BOP. BMI and WHR were used for assessing obesity. In addition, HbA1c and fasting plasma glucose levels were used for elimination of diabetes mellitus. Based on the periodontal and anthropometric measurements, individuals n76 were divided into four groups: the periodontal-healthy group n19, chronic periodontitis group n19, periodontal-healthy with obesity group n19 and chronic periodontitis with obesity group n19. Periodontitis patients received nonsurgical periodontal therapy. GCF sampling and clinical periodontal parameters were assessed before and 6 weeks after therapy. Vaspin, omentin, and TNF-α levels were measured by enzyme-linked immunosorbent assay. 