 TYPE OF STUDY randomized, double-blind, placebo-experimental. GENERAL PURPOSE To determine the efficacy of mirtazapine for the treatment of cocaine dependence. SPECIFIC OBJECTIVES 1 To evaluate the efficacy in the treatment of craving in individuals with cocaine dependence disorder treated with mirtazapine during acute withdrawal phase. 2 Determine the efficacy of reducing anxious depressive symptomatology Crash associated with acute withdrawal in subjects with cocaine dependence disorder treated with mirtazapine. 3 Evaluate the maintenance of abstinence in patients with cocaine dependence disorder treated with mirtazapine. 4 Determine the efficacy of mirtazapine in the treatment of subjects dependent on cocaine comorbid with major depressive disorder. 