 - Symptomatic, untreated, or uncontrolled central nervous system CNS metastases or seizure disorder; patients with asymptomatic CNS metastases treated with whole brain radiation WBRT or gamma knife radiosurgery GKR may be enrolled 1 week after completion of WBRTGKR provided toxicities are Common Toxicity Criteria CTC grade I at the time of registration andor controlled with dexamethasone 2 mg once daily for at least 5 days at the time of study treatment; patients with symptomatic CNS metastases treated with WBRTGKR may be enrolled 2 weeks after completion of WBRTGKR provided toxicities are CTC grade 1 at the time of registration and neurologic symptoms controlled with dexamethasone 2 mg once daily for at least 1 week at the time of study treatment 