 - History of cardiac disease: congestive heart failure defined as Class II to IV per New York Heart Association NYHA classification; active coronary artery disease CAD; previously diagnosed bradycardia or other cardiac arrhythmia defined as Grade 2 according to National Cancer Institute NCI-Common Terminology Criteria for Adverse Events CTCAE version 3.0, or uncontrolled hypertension; myocardial infarction occurred within 6 months prior to study entry myocardial infarction occurred 6 months prior to study entry is permitted 