 If clinically indicated, as per standard of care, during week 16 study subjects may have a CT scan of the chest, abdomen and pelvis and extremities or neck to assess for response, using Immune related Response Criteria irRC. MRI of the brain may also be obtained as part of clinical follow of their disease, as per standard of care. Study subjects who have possible progression or inflammatory pseudoprogression of disease but no significant functional decline will be kept on study at the discretion of the investigator. 