 3.0 Core members of the trial and project management We have a well-built core group with long-term and strong working relationships, including surgeons Drs. Anderson Co-PI and Durham, Pathologists Drs. Berean Co-PI and Zhang, and Oral Medicine Drs. Poh PI and Williams, and are in a world-leading position in using fluorescence visualization in operating room and in follow-up. Dr. J. Lee, collaborator, from M.D. Anderson Cancer Centre and has extensive experience in clinical trials with special expertise in randomized controlled trial. He will be the trialist in this project, design a program for patient randomization, oversee the trial protocol, and work with local statistician Prof. Chen for day-to-day data management. Professor Jiahua Chen, Department of Statistics, the University of British Columbia will serve as the biostatistician to the trial and will be responsible for the data analysis and submission of interim analyses to the Data Safety Monitoring Board. 