 Plasminogen activator inhibitor- 1 PAI-1 is the primary inhibitor of plasminogen activators and inactivates tissue plasminogen activator t-PA and urokinase-type plasminogen activator u-PA. PAI-1 is an important inhibitor of the fibrinolytic system, and elevated levels could suppress fibrinolysis and result in an increased risk of thrombosis. Increased PAI-1 levels have been shown to be associated with a number of atherosclerotic risk factors, PAI-1 has been shown to act as a prothrombic factor in both arterial and venous thromboembolic disorders. 