 60 male subjects, age 40 to 65 years of age, will be placed on a 3500kcal 55 carbohydrates containing 200 g fructose for 2 weeks. Half will receive allopurinol mgday randomized. At the end of 2 weeks we measure a variety of parameters including fasting glucose and insulin levels with calculation of HOMA index, serum lipids including triglycerides and LDLHDL cholesterol, sitting blood pressure, serum uric acid, weight, and various other measurements C reactive protein, adiponectin and leptin levels, and urate redox products. Primary endpoint is insulin resistance. Secondary endpoints are blood pressure, lipids, uric acid, weight. 