 - Systemic diseases, namely severe general diseases, systemic arterial hypertension systolic pressure 200 mmHg, despite medical therapy, acute systemic inflammation erythrocyte sedimentation rate 30 mm within the first hour C-reactive protein 1,0 mgdl, antithrombin-III deficiency in case of thrombocytopenia 100000 per ml: pathologic clotting time, acute pancreatitis with elevated pancreas enzymes 