 7. Subjects with a history of clinically significant neurological, metabolic, hepatic, renal, hematological, pulmonary, cardiovascular, gastrointestinal, andor urological disorders e.g. unstable angina, decompensated congestive heart failure, Central Nervous System CNS infection or history of HIV seropositivity, which would pose a risk to the patient if they were to participate in the study or that might confound the results of the study. Active medical conditions that are minor or well controlled are not exclusionary if they do not affect risk to the patient or the study results. For example, the following are not exclusionary: a stable and well- controlled hypertension; b asthma no serious attacks in the past year 