 - Acute multiple myeloma related renal failure Diagnosis established by clinical and laboratory findings including renal biopsy - if indicateda Newly diagnosed patients:Decrease of GFR to 50mlminb Previously treated patients with GFR of 60mlmin within last 4 weeks: decrease in GFR 25 and to 60ml min,concomitantly with either increase in paraproteins 25 andor decrease in hemoglobin 2 gdl within 4 weeks andor increase in bone marrow plasma infiltration andor increase in number of bone lesions andor hypercalcaemia Ca 11.5 mgdl or 2.8 mmoll as signs of disease progression 