 2. Serum total bilirubin 1.5 x ULN upper limit of normal. Higher levels are acceptable if these can be attributed to active red blood cell precursor destruction within the bone marrow ie, ineffective erythropoiesis. Subjects are excluded if there is evidence of autoimmune hemolytic anemia manifested as a corrected reticulocyte count of 2 with either a positive Coombs test or over 50 of indirect bilirubin 