 Primary Sjögrens syndrome pSS can affect various organs, sometimes leads to life-threatening conditions and is always responsible for a decreased quality of life. Its evolution is chronic, with flares and relapses, and the need for reliable biomarkers to be carried out routinely is major in patients follow-up. Because of the existence of autoreactive immunoglobulins E IgE in autoimmune diseases, the recently described role for anti-RoSSA antibodies in inducing interferon alpha IFNα signaling and the specific pharmacologic properties of IgE, anti-RoSSA IgE should be an interesting biomarker to determine pSSs activity. The aim of the study is to evaluate whether the proportion of anti-RoSSA IgE positive patients is higher in patients with active disease i.e. Eular Sjögren Syndrome Disease Activity Index 5. All consecutive patients with pSS new or already known diagnosis will be included, Anti-RoSSA IgE titers will be determined, the diseases features will be collected including Eular Sjögren Syndrome Disease Activity IndexEular Sjogrens Syndrome Patient Reported Index. 