 22. Active substance abuse e.g., alcoholism, cocaine, heroin, crack, methamphetamine, phencyclidine. Upon evaluation, if the physician-investigator considers that this substance abuse does not put the volunteer at risk for an adverse ie. cardiovascular event, or if the physician-investigator feels that the volunteer will be reliable and compliant with the treatment regimens, and that this substance abuse will not interfere with the study medications, exercise regimens, or data interpretation, then at the physician-investigators discretion the volunteer may be eligible. 