 - The presence of any ocular disease or condition that is active or is likely to flare up during the course of the study or any systemic diseasecondition that is affecting or has affected the eye in the past and may flare up, or the treatment of which may have an adverse effect on the eye. Eye conditions that are stable and of long standing, such as scars from trauma, pinguecula, atrophic pterygia etc, should not be considered as reasons to exclude the patient. 