 Cutaneous leishmaniasis is a disfiguring infection that can progress to mucosal leishmaniasis, a more serious and possibly fatal form of leishmania infection. All available medical therapies require weeks of treatment and cause significant toxicity. In Brazil, a standard therapy is Glucantime treatment, administered in cycles of 10 consecutive, once daily, intramuscular injections Glucantime 10 mgkg, maximum of 850 mg, followed by 11 consecutive days without Glucantime injections rest days. At the completion of each cycle, a study physician examines the patient to determine if a further cycle of Glucantime treatment is indicated. 