 i. Uncontrolled neuropathy grade 2 regardless of cause ii. Unstable angina andor congestive heart failure requiring hospitalization within the last 6 months iii. Transmural myocardial infarction within the last 6 months iv. Acute bacterial or fungal infection requiring intravenous antibiotics at the time of registration v. Chronic Obstructive Pulmonary Disease exacerbation or other respiratory illness requiring hospitalization or precluding study therapy within 30 days of registration vi. Severe hepatic disease, defined as a diagnosis of Child-Pugh Class B or C hepatic disease vii. HIV positive with CD4 count 200 cellsmicroliter. Note that patients who are HIV positive are eligible, provided they are under treatment with highly active antiretroviral therapy HAART and have a CD4 count 200 cellsmicroliter within 30 days prior to registration. Note also that HIV testing is not required for eligibility for this protocol. 