 1. Any subject with a history of diabetes mellitus on medications, or other serious medical condition, such as chronic hepatic or renal disease, bleeding disorder, congestive heart disease, chronic diarrhea disorders, myocardial infarction, coronary artery bypass graft, angioplasty within 6 months prior to screening, current diagnosis of uncontrolled hypertension defined as systolic BP160mmHg, diastolic BP95mmHg, active or chronic gastrointestinal disorders, bulimia, anorexia, or endocrine diseases except thyroid disease requiring medication as indicated by medical history or routine physical examination. 