 Infants with Wolman disease may experience the loss of previously acquired skills required the coordination of muscle and motor skills psychomotor regression. The symptoms of Wolman disease often get progressively worse eventually leading to life-threatening complications during infancy including extremely low levels of circulating red blood cells severe anemia, hepatic dysfunction or failure, and physical wasting away and severe weakness often associated with chronic disease and marked by weight loss and loss of muscle mass cachexia or inanition. 