 Most potential participants will be given the participant information sheet PIS when they are seen for their booking visit by the community midwife. The midwife will assess their eligibility for the study and hand out the PIS if they fit the inclusion criteria. The midwife will inform the research team of the mothers details via a Reply Slip if she has no objection to be contacted. The research team will then contact the mother and if possible, the recruitment visit will be planned to coincide with her booking bloods or dating scan appointment usually around 12 weeks of gestation to minimise the study visits Research Team Recruitment, see right-hand side of Recruitment Flow chart. 