 - Refractory to first line and relapsed after second line. Chemotherapy combinations may include, but are not limited to: CHOP Cyclophosphamide, doxorubicin, vincristine, prednisone, R-CHOP Rituximab, Cyclophosphamide, doxorubicin, vincristine, prednisone, FCM Fludarabine, cyclophosphamide, mitoxantrone, R-FCM Rituximab,Fludarabine, cyclophosphamide, mitoxantrone, ICEIfosfamide, carboplatin, etoposide, DHAP Dexamethasone, cisplatin, cytarabine and hyper-CVAD Cyclophosphamide, doxorubicin, vincristine, dexamethasone. 