 The purpose of this study is to determine the feasibility and short- and long-term efficacy of an empirically-based CST intervention Keefe et al. with caregivers of patients with primary malignant brain cancer. The target sample will be 20 caregiver-patient dyads. The caregiver may be a spousepartner, family member or friend,. Additional inclusion criteria will include: 1 caregiver provides a weekly minimum of 4 hours of caregiving; 2 caregiver is 18 years or older; 3 caregiver reading level at or above 8th grade; 4 caregiver sufficiently fluent in English; 5 the patient shows evidence of problems in depression, fatigue, sleep disturbance, andor cognitive impairment as per the treating neuro-oncologist; 6 the caregiver and patient are willing to be randomized to treatment or usual care condition; 7 patient is within 3 months of initial diagnosis; 8 patient has life expectancy of at least 6 months or more; 9 the caregiver is willing to participate in treatment sessions using a telephone. If a patient dies during the active 12-week study phase, then the caregiver will be transitioned to the follow-up phase or removed from the study and, if needed, be referred for appropriate psychiatric or psychological treatment. 