 - Compare the efficacy of neoadjuvant high-dose carboplatin and etoposide, vincristine, and cyclosporine CSA followed by ophthalmic focal therapy comprising cryotherapy andor laser therapy to historical world data of chemotherapy treatment without CSA, in terms of increasing the proportion of eyes that remain relapse free and do not require external beam radiotherapy andor enucleation, in patients with newly diagnosed Group B, C, or D bilateral intraocular retinoblastoma. 