 In our previous study, olanzapine and risperidone were demonstrated to affect eating behaviors and weightBMI compared to placebo in a 2 week paradigm in normal healthy human subjects. Behaviors affected included appetite, reported calories consumed per day, and observed calories consumed in a feeding laboratory. No effects were seen on resting energy expenditure corrected for lean body weight. Also, sedation was reported in 81.3 and 75 of the olanzapine and risperidone groups respectively. Sedation was the primary reason, in both groups, for medication dose reductions. 