 - Adequate bone marrow, liver and renal function: Hemoglobin 9.0 gdl; Absolute neutrophil count ANC1,500mm3; Platelet count correctable to 50,000mm3; compensated liver function Child-Turcotte-Pugh A, B7 or B8; Creatinine 1.5 times ULN; INR correctable to 1.5. 