 - Cardiac abnormalities as evidenced by any of the following: History or current clinically significant uncontrolled arrhythmias or hypertension; Clinically significant conduction abnormalities or arrhythmias, subjects with Bundle Branch Block; Presence of cardiac pacemaker; History or evidence of current Class II congestive heart failure as defined by New York Heart Association NYHA; History of acute coronary syndromes including unstable angina and myocardial infarction, coronary angioplasty, or stenting within the past 3 months. 