 In a small group of people gluten, a storage protein commonly in wheat and other grains, can cause gut inflammation and symptoms like diarrhea and abdominal pain. Gluten-related disorders include celiac disease CD and non-celiac gluten sensitivity NCGS and are treated by starting a gluten free diet GFD. Patients with CD and NCGS also more commonly experience esophageal reflux and damage to the lining of the esophagus. A potential consequence of long-standing heartburn is Barretts esophagus BE, a major risk factor for cancer of the esophagus. 