 Haemoglobin Hb 10.0 gdL Absolute neutrophil count 1.5 x 109L Platelet count 100 x 109L Serum bilirubin 1.5 x upper limit of normal ULN except for patients with documented Gilberts disease Alanine aminotransferase ALT and aspartate aminotransferase AST 2.5 x ULN unless raised due to tumour in which case up to 5 x ULN is permissible 