 Subjects randomized in Study ROPP-2008-01, Section D are eligible to enroll in this study; completion of Study ROPP-2008-01 Section D is not required. Subjects in Study ROPP-2008-01 are premature infants gestational age of 23 weeks 0 days to 27 weeks 6 days who are randomized to receive either treatment with rhIGF-1rhIGFBP-3 or standard neonatal care. Up to 120 subjects are planned to be randomized in Study ROPP-2008-01 Section D. 