 7. A sufficient interval must have elapsed between the last dose of prior anti-cancer therapy including cytotoxic and biological therapies and major surgery and enrollment, to allow the effects of prior therapy to have abated: a Cytotoxic or targeted chemotherapy: greater than or equal to the duration of the cycle of the most recent treatment regimen a minimum of 3 weeks for all regimens, except 6 weeks for nitrosoureas and mitomycin-C. b Biologic therapy e.g., antibodies: greater than or equal to 4 weeks. 