 The sample size will be adequate to achieve a 95 level of confidence with an acceptable margin of error. Consistent with stringent inclusion and exclusion criteria, it is anticipated that a fairly homogeneous and comparable study groupings can be identified. Again, due to the limited number of TMS patients eligible for enrollment in the study, a non-random, non-probability assignment or matching method will be used to make sure the study groups, based upon the demographics and clinical characteristics, are similar in the most important respects. 