 7. Any contraindication to thrombolytic therapy -Central nervous system damage or neoplasms or atrioventricular malformation -Recent major traumasurgeryhead injury within the preceding 3 weeks -Gastrointestinal bleeding within the past month -Known bleeding disorder excluding menses -Aortic dissection -Non-compressible punctures in the past 24 hours e.g. liver biopsy, lumbar puncture. 