 Endometrial cancer is the most common gynecologic malignancy with 40,100 new cases diagnosed and 6,800 deaths attributable to this malignancy in 2003. Most patients diagnosed with endometrial cancer have early stage disease that is amenable to treatment with hysterectomy and bilateral salpingo-oophorectomy with excellent clinical outcomes. Surgical staging has improved accuracy over clinical staging for defining a low risk population of patients who have favorable long-term outcomes with surgery alone. However, approximately 15 of patients will have evidence of Stage III or IV disease at the time of initial diagnosis and 15 of surgical Stage III patients will have recurrent disease. Radiation therapy will be effective in patients with disease confined to the pelvis; however, patients with metastatic disease will require more systemic therapy in order to control disease. 