 The investigators have established a Consortium of 9 geographically-dispersed clinical research sites to study rare disease of the airways, including Primary Ciliary Dyskinesia PCD. PCD is a genetic disorder with defective mucociliary clearance MCC, sinus and pulmonary disease with chronic infection, and organs located on the wrong side of the body in about 50 of patients Kartagener Syndrome. Lung disease occurs early in children with PCD, but establishing a diagnosis remains a major challenge, based on the traditional approaches of using electron microscopy andor ciliary waveform analysis to define abnormalities of ciliary ultrastructure andor function. 