 - Must have an unsatisfactory response inadequate efficacy or poor tolerability that includes all 3 classes of analgesic medications acetaminophenparacetamol, NSAID, and an opioid; For participants in the USA and Canada: Must have an unsatisfactory response inadequate efficacy or poor tolerability that includes all 3 classes of analgesic medications acetaminophenparacetamol, NSAIDs, and opioids other than codeine or codeine combination products 