 MP is a psychostimulant that acts by inhibiting presynaptic dopamine transporters leading to suppression of dopamine reuptake Prommer, 2012. That is, due to reuptake suppression, more dopamine remains in the synapses. MP primarily affects the striatum which receives dopamine neuron projections from the substantia nigra pars compacta and subsequently the prefrontal cortex PFC, which receives dopaminergic projections from the striatum Volkow et al., 2001. 