 NRTIs are an important part of many ARV regimens used to treat HIV infected patients; however, the relationship between NRTI-induced mitochondrial dysfunction and lipoatrophy is still unclear and requires additional research. Additionally, the relationship between the gain in dual-energy x-ray absorptiometry DEXA-measured limb fat and mitochondrial DNA mtDNA content, mitochondrial function, fat apoptosis, and oxidative damage will also be examined in this study. 