 Prior treatment with a BRAF inhibitor including but not limited to dabrafenib GSK2118436, vemurafenib, and LX281BMS-908662 or a MEK inhibitor including but not limited to trametinib GSK1120212, AZD6244, and RDEA119; NOTE: There is no limit to the number of other prior therapies, and patients may be previously untreated. 