 Ongoing clinical studies are investigating with radiotherapy abscopal effect alone, or associated with immunotherapies anti-CTLA-4, PD-1 or PDL-1. The present study proposes a new association, based on an original biological rational. The proposed theory is based on combination of radiation therapy with usual targeted therapies capable of ADCC Antibody-Dependant Cell Cytotoxicity. This association could enhance in an additivesynergistic way the benefic impact of immune system activation on tumor control. 