 b. MDSMPN as defined by the WHO criteria, including CMML, atypical CML, and MDSMPN-Unclassifiable fulfilling the criteria listed below i. relapsedrefractory disease ii. Requiring therapy based on the presence of one or more cytopenias Hb 10 gdL andor red cell transfusion dependence, platelets 50,000μL, or ANC 1,000 μL, excess blasts 5 in the peripheral blood or bone marrow, or palpable splenomegaly iii. or previously untreated subsets e.g atypical CML, MDSMPN unclassifiable requiring therapy as defined above and in whom no approved therapies exist. 