 This study will enroll 150 men with previous negative biopsies and clinical suspicion of prostate cancer due to serum level of PSA higher than 2.5 ngml or abnormal digital rectal examination DRE or patients in active surveillance due to low risk prostate carcinoma. Anatomical magnetic resonance imaging MRI and diffusion weighted imaging DWI at 3 Tesla T magnetic field using surface coils will be used to non-invasively predict the presence or absence of prostate cancer. In addition to routine 12-core TRUS biopsies, targeted TRUS guided biopsy based on MRI findings will be performed. 