 5 Inability to take oral medications for any reason 6 Severe sepsis or septic shock defined as unresolved hypotension MAP70 or tachycardia HR110, or requirement of inotropic support or ventilation at time of eligibility. Should the subjects hypotension or tachycardia subsequently resolve, and they cease to require inotropes and ventilation within 7 days, they may be reconsidered for eligibility. 