 This is an exploratory mixed-methods research study that compares an efficacious behavioral HIV-prevention intervention 3MV alone to the behavioral HIV-prevention intervention combined with a biomedical intervention PrEP. After completing the 3MV behavioral intervention, participants will be randomly assigned to one of three study arms: 1 daily FTCTDF as PrEP, 2 placebo pill control, or 3 no pill control. Behavioral and biomedical data will be collected at baseline and every 4 weeks thereafter for 24 weeks. Youth who decline to participate will be asked to complete a brief survey about their opinions on PrEP. Qualitative interviews will be completed with six study participants and the study coordinators at the end of the trial to explore further the issues of trial acceptability and feasibility. Finally, focus groups will be conducted to explore feasibility and acceptability issues with YMSM who meet all eligibility requirements of the study except for not being age 18 or older, but are at least 16 years of age. 