 Imiquimod is a topical cream that affects the immune response and has been noted to inhibit blood vessel formation. It has been used to successfully treat other vascular growths such as hemangiomas. The research can use imiquimod cream 5 cream apply to port wine stains after laser therapy to improve lightening of port wine stains. The imiquimod 5 cream cream apply to Port wine stains everyday for 8 weeks. 