 Zoledronate 4 mg will be administered by intravenous infusion details below at baseline within 72 h of liver transplantation, followed by zoledronate 4 mg infused as outlined below at 1, 3, 6 and 9 months post-transplantation PLUS calcium 600mg daily Caltrate, one tablet and ergocalciferol 1000 IU daily Ostelin, one capsule for 12 months post-transplantation. 