 - Subjects currently receiving weight loss treatment such as, but not limited to: crashstarvation diets e.g. 800ckalday, ALLITM Orlistat, Ephedra ma-huang or other ephedrine based treatments, Cascara or other herbal treatments which, in the opinion of the investigator andor GSK Medical Monitor, contraindicates the subjects participation. Subjects must not participate in any of the weight loss treatment outlined above during the course of the study Part 2 only. 