 Non-child bearing potential i.e., physiologically incapable of becoming pregnant, including any female who is post-menopausal or surgically sterile. Surgically sterile females are defined as those with a documented hysterectomy andor bilateral oophorectomy or tubal ligation. Post-menopausal females are defined as being amenorrhoeic for greater than 1 year with an appropriate clinical profile, e.g., age appropriate, 45 years, in the absence of hormone replacement therapy. In questionable cases for women 60 years of age, a blood sample with simultaneous follicle stimulating hormone and estradiol falling into the central laboratorys postmenopausal reference range is confirmatory. 