 The Novel Motorized Spiral Endoscope represents a new technology which offers all of the advantageous options of spiral-assisted endoscopy with a faster and less invasive approach. The system is similar to other currently marketed endoscopes in that it incorporates a flexible insertion tube, light source, digital imaging, and channels for passing accessories for sample collection or therapeutic interventions. The system is unique in that it incorporates a user-controlled motor contained in the endoscopes handle to rotate a spiral cuff located on the endoscopes insertion tube. Rotation of this cuff, which has soft spiral-shaped fins, pleats the colon on to the endoscopes insertion tube, thereby allowing rapid and atraumatic access into the colon. The system also includes a display monitor, a motor control unit, device to display measured motor current and signal torque, and a set of foot pedals. It is currently being evaluated in a prospective study in patients with indications for antegrade enteroscopy European Novel Motorized Spiral Endoscopy Trial ENMSET in the two centers conducting this study. So far more than 60 patients were successfully examined without major adverse events. 