 Stimulation site is another important treatment factor; thus far almost all of the trials of rTMS in TRD conducted have evaluated the utility of high frequency left prefrontal cortex PFC rTMS HFL-TMS. In addition, several studies have evaluated the treatment efficacy of low frequency rTMS to right PFC LFR-TMS. In a previously published study we have demonstrated that these two approaches have similar therapeutic benefit and both were superior to sham stimulation. 