 3-Estimated GFR 25 mlmin1.73 m2 4- Upc 1.0 g proteing creatinine on first am void 5- Steroid and IS resistance as defined by primary physician patients with little or no reduction in protein excretion at 12 to 16 weeks are considered to be steroid resistant --A relapse is return of proteinuria to 3.5 gday in someone who had undergone a complete or partial remission- IS resistance: no response to IS in 8-12 weeks 6-At least one month from last immunization received has passed 7- Ability to understand and willingness to sign consent by patient legal guardian 