 In this study the clinical effect of SRT for these diseases is evaluated on a long-term basis. For diabetic macular edema previously non-treated eyes with focal or diffuse macular edema are randomized to SRT or conventional treatment. Best corrected visual acuity has to be at least 0.1 and no central ischemia must be present. The endpoint is visual acuity and reduction of edema as determined by fundus photography, angiography and optical coherence tomography. Regarding central serous chorioretinopathy visual acuity decay should last longer than 2 months with angiographically seen leakage outside the fovea. Endpoint is visual acuity and reduction of subretinal edema as determined by optical coherence tomography. Regarding AMD drusen maculopathy has to show soft confluent drusen and hyperpigmented spots. Angiographically a choroidal neovascularization has to be ruled out. Both eyes of the patient must have symmetric patterns since one eye is treated and the other one observed. End point would be a visual acuity and reduction of drusen as determined by fundus photography. For geographic atrophy due to age-related macular degeneration both eyes of the patient should present symmetric areas of atrophy. Laser treatment takes place at the rim of the atrophy zone in one eye whereas the other eye is observed. Due to RPE proliferation induced by SRT the major endpoint for this entity will be the stop or reduction of geographic atrophy enlargement in the treated eye compared with the fellow eye. Visual acuity should be at least 0.1. 