 - Arrhythmia eg, history of polymorphic ventricular fibrillation or torsade de pointes; permanent atrial fibrillation a fib defined as a fib 6 months; persistent a fib defined as sustained a fib lasting 7 days andor requiring cardioversion in the 4 weeks before screening; however, patients with grade 3 atrial fibrillation a fib for a period of at least 6 months may enroll; grade 3 a fib is symptomatic and incompletely controlled medically, or controlled with device e.g., pacemaker, or ablation; patients with paroxysmal a fib are permitted to enroll 