 Shifting from the current paradigm of using X-ray based modalities to assess fracture risk, the reference point indentation RPI method acquires direct measurements of materal quality of the bone tissue. Specifically, the OsteoProbe-RPI engages the patients bone, and upon applying an impact force, it measures the ability of the tissue to resist micro-indentation. Despite the encouraging results from aformentioned studies applying RPI to bone, there is no evidence that a local measurement of bone material quality are predictive of fracture resistance at sites that are prone to fragility fractures e.g. the proximal humerus. 