 3. Patients must have Measurable Disease: Lesions that can be accurately measured in at least one dimension longest diameter to be recorded as 20 mm with conventional techniques or as 10 mm with spiral CT scan. Lesions that are not considered measurable include bone lesions, leptomeningeal disease, ascites, pleuralpericardial effusion, abdominal masses that are not confirmed and followed by imaging techniques, cystic lesions and tumor lesions situated in a previously irradiated area. 