 - Sexually active subjects men and women must agree to use medically accepted barrier methods of contraception eg, male or female condom during the course of the study and for 4 months after the last dose of study drugs, even if oral contraceptives are also used. All subjects of reproductive potential must agree to use both a barrier method and a second method of birth control during the course of the study and for 4 months after the last dose of study drugs. 