 1. Histologically handling of tissue: previous identification of pathologic lesions as described in inclusion criteria by an expert pathologist sample with lesion but without necrosis, the paraffin block will be cut into 5 to 7 μm slides with new blades and gloves for each cut. It will be obtain 1 slides that will be distributed as follows: one sample will be send to Laboratorio de Virología Molecular del Instituto Venezolano de Investigaciones Científicas; the remained sample will be kept for further evaluation if is necessary. Each slide will be placed in a proper container and will be identified by a serial number in order to preserve patient intimacy and avoid biased results. 