 Inclusion Criteria: - High-risk, stage II-III breast cancer suitable for treatment with up to 6 cycles of FEC-100 - Chemotherapy - Histologically proven greater than or equal to 1 axillary nodes positive - Oestrogen receptor negative or positive - Chemotherapy naïve - VES 13 Vulnerable Elders Survey score less than or equal to 3 - ECOG performance status less than or equal to 2 - ANC greater than or equal to 1.5 x 109L - Platelets greater than or equal to 100 x 109L - Adequate renal function serum creatinine less than 1.5 x upper limit of normal ULN - Before any study specific procedure the subject must give written informed consent for participation in the study Exclusion Criteria: - Total serum bilirubin greater than ULN according to institutional standard - Clinically significant cardiac disease that would preclude the use of epirubicin e.g., LVEF left ventricular ejection fraction less than 45 at rest by MUGA or echocardiogram - Prior bone marrow or stem cell transplantation - Any premalignant myeloid condition or any malignancy with myeloid characteristics e.g., myelodysplastic syndromes, acute or chronic myelogenous leukaemia - History of prior malignancy other than breast cancer with the exception of curatively treated basal cell carcinoma, in situ cervical carcinoma or surgically cured malignancies - Prior radiation therapy - Active infection or administration of systemic antibiotics or anti-infectives within 72 hours before start of chemotherapy - Known hypersensitivity to E coli-derived products e.g., Filgrastim, HUMULIN, Insulin, L-Asparaginase, HUMATROPE, Growth Hormone, INTRON A - Previous exposure to pegfilgrastim or previous entry into this study - Known HIV infection - Inability to understand the nature of the study and provide written informed consent - Subject currently enrolled in another investigational device or drug trials or has received other investigational agents, with the exception of placebo-treated subjects, within the last 30 days - Concerns for subjects compliance with the protocol procedures 