 4. No contraindication for chemotherapy, with normal peripheral hemogram, renal and hepatic function: Peripheral hemogram: WBC4.0×109L,PLT80×109L,Hgb90gL; Renal function: serum BUN and creatinine 2.5×UNL; Hepatic function: transaminase2.5×UNL, or 5×UNL in patients with liver metastasis; 