 - Has adequate baseline organ function as defined: ANC 1.2×109liter L, hemoglobin9 gram gdeciliter dL, Platelets75×109L, partial thromboplastin time PTT, prothrombin time PT and International normalization ratio INR 1.5 times upper limit of normal ULN, albumin 2.5 gdL, total bilirubin 1.5 times ULN alanine aminotransferase ALT 2.5 times ULN, Creatinine or calculated creatinine clearance 50 milliliter mLminute min and left ventricular ejection fraction LVEFlower limit of normal LLN by echocardiogram ECHO or multigated acquisition scan MUGA. 