 - Left ventricular ejection fraction 50 measured by echocardiography or MUGA but in the presence of significant co-morbidities or cardiac risk factors such as diabetes mellitus, hypertension, peripheral vascular disease, ischaemic heart disease, previous myocardial infarction, obesity, stroke or transient ischaemic attacks TIA that make anthracycline-containing chemotherapy inadvisable as determined by the investigator. 