 The present study will extend the follow-up evaluation of Alair-Treated Subjects from the PREDECESSOR STUDY to 5 years post-treatment with the Alair System. These evaluations will consist of four study visits corresponding to the two-year, three-year, four-year and five-year time points following completion of Alair treatments in the PREDECESSOR STUDY. For consistency with the PREDECESSOR STUDY, ideally the subjects drug therapy should continue to be consistent with GINA Guidelines for the severity of the subjects asthma. Any changes in maintenance levels of asthma medications will be documented. 