 No study has ever evaluated a patients symptoms before and after replacement with thyroid hormone when the patient is euthyroid before thyroid hormone therapy. The assumption has been made that if serum TSH is normalized, thyroid hormone levels are adequate and that symptoms of hypothyroidism have been relieved. The investigators know from large community based studies that symptoms of hypothyroidism persist despite what the investigators believe is adequate thyroid hormone replacement in as many as 10 of patients. Our study will be the first to test the same patient, before and after thyroidectomy so the investigators can directly compare normal endogenous thyroid function with levothyroxine LT4 therapy resulting in the same serum TSH. Thyroidectomies are often performed for large nodules or nodules that show indeterminate or suspicious cytology after fine needle aspiration biopsy, but turn out to be benign at final histological diagnosis. The current standard of care is to replace thyroid hormone with LT4 to normalize the serum TSH. Our approach uses the same patient as their own control and eliminates numerous variables that cannot be controlled for in other studies including: variable onset of hypothyroidism, degree of endogenous thyroid function and underlying cause of hypothyroidism. 