 The secondary subjective efficacy endpoints are: 1 the mean change from Baseline to the end of the Treatment Period in International Restless Legs Syndrome IRLS Rating Scale total score, 2 proportion of responders much very much improved on the investigator-rated Clinical Global Impression-Improvement CGI-I scale, and proportion of responders moderately better to a great deal better on the Patient Global Impression of Change PGIC scale 4 the mean change from baseline to the end of the Treatment Period in PSQ, SSQ items, RLSQoL, RLS-NDI and ESS scores 