 2. Patients have impaired cardiac function or clinically significant cardiac diseases, including any of the following: a History or presence of serious uncontrolled ventricular arrhythmias or presence of atrial fibrillation; b Clinically significant resting bradycardia 50 beats per minute; c LVEF assessed by 2-D echocardiogram ECHO or multiple gated acquisition scan MUGA 45; d. pericardial effusion 