 At the Screening visit Visit 1, Day -10 to -7, the subjects will be assessed by the PI or designee to confirm inclusion into the study. Expert grading and Canfield VISIA CR photographic documentation all flash modes including RBX will be performed at baseline Visit 2, Day 0, Week 4 Visit 3, Day 28 7 days, and Week 8 Visit 4, Day 56 7 days. 