 2. All female subjects must be of non-child-bearing potential. For the purposes of this study, this is defined as the subject being amenorrheic for at least 12 consecutive months, or at least 6 weeks post-surgical bilateral oophorectomy with or without hysterectomy, or women who underwent tubal ligation. Menopausal status will be confirmed by demonstrating levels of follicle stimulating hormone FSH 40 - 138 mIUml and oestradiol 20 pgml at entry, unless this information is available in the subjects medical record. In the event a subjects menopause status has been clearly established for example, the subject indicates she has been amenorrheic for 10 years, but FSH andor oestradiol levels are not consistent with a post-menopausal condition, determination of subject eligibility will be at the discretion of the principal investigator following consultation with the sponsor and medical monitor 