 The comparative effectiveness of health workers-TB care to that of volunteer CHW-TC and SA-TC in randomized control trials has never been reported so far. It is hypothesized that no significant difference in cure and treatment completion rate among the three care groups would be shown, taking the prevailing health facility-based TB care as the gold standard of care. The sample size for PTB 179 patients per arm was planned to detect at least a 10 difference in treatment success rates between any of care groups assuming 85 treatment success rate in the highest arm and a baseline treatment success rate of 72 with a power of 80 at a significant level of 5. With the same assumption 85 treatment completion rate in the highest arm and a baseline treatment completion rate of 69, all eligible PTB- patients 131 patients per arm should also be included during the study period. Separate comparisons of effectiveness between the three methods of TB care will be carried out for PTB and PTB- patients. Comparison of effectiveness of the care groups will be undertaken according to the principle of intention-to-treat. The strength of association between treatment outcomes and each care group will be determined using the chi-square test. Adjusted effects of patients characteristics, area of residence, HIV status, time elapsed by each patient for treatment, the type of health facility and method of TB care used on treatment outcomes will be computed using logistic regression analysis. 