 - WHO 2008 diagnosis of Polycythemia Vera Hemoglobin 18.5 gdl for men 16.5 gdl for women and presence of JAK2V617F mutation and either bone marrow trilineage myeloproliferation or subnormal serum erythropoietin level Patients may be on active treatment phlebotomy, aspirin ECOG performance status 0,1,2,or 3 Adequate hepatic function, adequate renal function 