 Patients also undergo selective internal radiation therapy SIRT comprising yttrium Y 90 resin microspheres on day 2 of chemotherapy course 1 for patients receiving FOLFOX6 or FOLFIRI chemotherapy regimens or on day 1, 2, 3, 4, or 5 of course 1 for patients receiving FUDR chemotherapy regimen. SIRT may repeat in week 10 or 12. 