 - Steroid-refractory CD: currently moderately active CD CDAI or mCDAI 200 - 450 despite treatment with 40 kg or 0.5 mgkgday if weighing 20 mgday if weighing prednisone 40 9 mgday for the previous 4 weeks prior to the screening kg, or budesonide evaluation. Prednisone or budesonide must be at a stable dose for 2 weeks prior to screening week -2. 