 - Adequate renal function: creatinine 1.5 x ULN for age; If serum creatinine is 1.5 ULN of age, then creatinine clearance or radioisotope GFR must be 70 mlmin1.73 m2 Adequate hepatic function: bilirubin 1.5 x ULN; AST and ALT 2.5 x ULN AST, ALT 5 x ULN in case of liver metastases. 