 V. To test the feasibility of performing correlative studies involving leukemic blasts obtained pre-treatment and 24-hours post-treatment to determine if events associated with in vitro synergism eg, down-regulation of phosphorylated p-Wee1 and p-checkpoint kinase 1 Chk1; dephosphorylation of cyclin-dependent kinase-like 1 cdc2 at both tyrosine Tyr15 and threonine Thr14; increased expression of gamma H2A histone family, member X H2A.X and of p-histone H3 HH3 can be recapitulated following exposure to AZD1775 and belinostat in patients. 