 Tissue plasminogen activator tPA is a protein involved in the breakdown of blood clots. As a result it has therapeutic uses in clinical medicine to treat thromboses and emboli. Electrical stimulation has been previously shown to provoke an acute release of tPA into the circulation, although it appears that this response decreases with repeated stimulations. Use of the gekoTM device has been shown to result in a significant decrease in Tissue Plasminogen Activator tPA antigen which is indicative of increased fibrinolytic activity. 