 4. Subject had used the following treatments for IBD: steroids or any or biologic immunomodulators or any topical treatments e.g. enemas within the last 4 weeks prior to baseline, immunosuppressants or antimetabolites within the preceding 6 weeks, antibiotic use within the previous 7 days or chronic use of any anti-inflammatory drugs except aminosalicylates within 7 days. 