 One 505mL aliquot of blood collected from each subject will be treated using the EDS process either active drug or sham and the resultant processed RBCs will be radiolabeled with Chromium-51 51Cr for the in vivo kinetic study. A second 105mL simultaneously collected sample will be labeled with Technetium-99m 99mTc to estimate the subjects blood volume. These labeled aliquots will be mixed, and simultaneously infused through a peripheral vein via butterfly or similar catheter total dose 20-40 μCi. Blood samples will be collected from the subjects contralateral arm immediately pre-infusion and at 5, 7.5, 10, 12.5, 15, 20, and 30 minutes 3 min, and on Day 1, 24 hours 2 h after completion of infusion. Vital signs will be assessed after the 30-min sample on Day 0 and again on Day 1 before the 24-h sample is collected. Additional blood samples will be collected at 48 4 h and 72 4 h hours and 7 1 d days post-infusion, and then weekly through 49 days post-infusion, with a window of 2 days for each visit. 