 Statistical analysis All data will be assumed to be non-parametric due to the small sample size. Data will be presented as median - interquartile range with all comparisons of single and multiple categorical and continuous matched and non-matched variables done accordingly. Correlation between the clinical and MR endpoints will be carried out with a Spearman test. A univariate analysis will be undertaken of the MR endpoints at 12 weeks for responders and non-responders. For all candidate parameters, κ reliability values based on X2 probability testing will be calculated. We aim to undertake a multiple regression model in order to create the best-fit weighted scoring system. Double-weighting will be applied for inflammatory scores versus anatomical scores. However, this may not be possible at this present stage but this work will provide the pilot data to properly power a downstream study. P values of less than 0.05 will be deemed significant. All analyses will be carried out with GraphPad Prism. 