 - Current symptomatic congestive heart failure New York Heart Association class II, unstable cardiac arrhythmia requiring therapy e.g. medication or pacemaker, unstable angina e.g. new, worsening or persistent chest discomfort, or uncontrolled hypertension systolic 160 mmHg or diastolic 100mmHg. Or any of the following occurring within 6 months 180 days prior to first dose of avelumab: Myocardial infarction, coronaryperipheral artery bypass graft, cerebrovascular accident or transient ischemic attack, or serious cardiac arrhythmia requiring medication. Use of antihypertensive medication to control blood pressure is allowed. 