 Iressa is a selective epidermal growth factor receptor tyrosine kinase inhibitor EGFR-TKI. It is an orally active agent for advanced non-small-cell lung cancer NSCLC in those who have failed a previous platinum-based regimen and taxane treatment. UFUR TegafurUracil is effective agent against chemo-naïve NSCLC. It has anti-angiogenesis effect when used as long-term low dose treatment. 