 Phase 2 - Baseline instrumental evaluation: measurements of brain volumetry and function functional magnetic resonance, EEG; cardiovascular assessment with ultrasound flow-mediated dilation of the brachial artery, measurement of carotid intima-media thickness and stiffness, aortic stiffness, pulse wave analysis and central blood pressures, modifications in brain blood flow, carotid blood flow and carotid diameter in response to stimuli; Phase 3 - Intervention 7 months for each patient. A protocol of aerobic physical activity will be undertaken, 1 hour three times per week, with the help of trained and experienced personnel, including but not limited to physiotherapists and personal trainers. The protocol includes a combination of aerobic exercises, muscular strengthening, balance improvement and joint flexibility. 