 Patients will be assigned to the HFO-TGI-group i.e., the intervention-group or the Conventional Mechanical Ventilation CMV-group i.e., the control-group according to a computer-generated, random number-sequence Furthermore, crossover from the CMV-group to the HFO-TGI-group will be performed whenever requested by the attending physicians. Randomization will be undertaken by the departments statistician and will be supervised by the Independent Main End Point and Safety Monitoring Committee, which will be the same as for NCT00416260, with an additional member at Larissa hospital. Group allocation will be concealed until study entry. 