 A multi-center, prospective, randomized, two-arm feasibility trial to assess the potential role of unloading with the Impella CP prior to revascularization in reducing infarct size. The study design includes 1:1 randomization between: 1 Delay Arm: 30 minutes of unloading with Impella CP prior to primary percutaneous coronary intervention PPCI; and 2 Immediate Arm: initiation of Impella CP unloading followed immediately by PPCI. 