 The United States Public Health Service USPHS guideline recommends nicotine replacement therapy and bupropion as first-line agents for the treatment of tobacco dependence. Bupropion acts by central dopamine and norepinephrine reuptake inhibition. St. Johns Wort SJW, a widely used herbal product to treat mild to moderate depression, shares a similar mechanism of action and is available as a tobacco cessation aid in a number of over-the-counter preparations. While currently approved pharmacotherapies for tobacco dependence cost between 120-240 per month, SJW is relatively inexpensive 15 per month and is well-tolerated. At present, no randomized prospective study of St. Johns Wort for tobacco cessation has been published. 