 The project is financially supported as a subproject of a larger PhD project. Salary of the PhD student, Marie Louise Mølgaard Binderup is financed by the Danish Cancer Society with approximately181,000 Euros, while the expenses of operation of the PhD project is supported by the Lundbeck Foundation with approximately 65,000 Euros, of which approximately 4,000 Euros is estimated to be used for expenses of the present subproject. The supporting organisations solely provide financial support and have no influence on study design, the execution of study, or publication of results. Initiators of this project will not apply for further financial support for this subproject. 