 - The normal numerical laboratory: The patients level of organ function must meet the following requirements: enough reserves: bone marrow neutrophils cent leaves and ribbon neutrophils absolute count ANC 1.5109 L, or platelets 100109 L, or acuity 9 gdL and hemoglobin.Liver: bilirubin 1.5 times the upper limit of normal, alkaline phosphatase AP, aspartate aminotransferase AST and alanine aminotransferase ALT 3.0 times the upper limit of normal If allowed to AP with liver metastasis, AST, ALT 5 times the upper limit of normal.Kidney: creatinine clearance or 45 mLmin. 