 - Adequate organ function including the following: Bone marrow: absolute neutrophil count ANC or 1.5x109L, platelets or 100x109L, hemoglobin or 9gdL. Hepatic: bilirubin 1.5 x ULN, alkaline phosphatase, aspartate transaminase AST and alanine transaminase ALT 2.5 x ULN alkaline phosphatase, AST, ALT 5 x ULN is acceptable if liver has tumor involvement. Renal: calculated creatinine clearance 45 mlmin. 