 Philadelphia-negative Ph-negative Myeloproliferative Neoplasms MPN include polycythemia vera PV, essential thrombocythemia TE, and primary myelofibrosis MF. Ph-negative MPN are chronic myeloid neoplasms that appear after a malignant transformation of a hematopoietic stem cell. There are many clinical manifestations of these diseases, which include polyglobulia, thrombocytosis, leukocytosis, cytopenias, extramedullary hematopoiesis e.g.: splenomegaly, increased thrombotic risk and the risk of transformation to acute myeloid leukemia AML. Life expectancy varies from 5-6 years for patients with MF to more than 15 years for patients with PV and ET. 