 3. Laboratory results sustained at:Neutrophils less than 1.5x109L or platelets less than 100x109L; Serum bilirubin 1.5 x the upper limit of reference range ULRR;Serum creatinine1.5xULRR or CrCl 30 mLminutecalculated by Cockcroft-Gault formula. Potassium,4.0 mmol despite supplementation;serum calcium ionized or adjusted for albumin,or magnesium out of normal range despite supplementation;Alanine aminotransferaseALTor aspartate aminotransferaseAST 2.5 x ULRR or alkaline phosphataseALP 2.5 x ULRR,or 5 x ULRR if judged by the investigator to be related to liver metastases 