 The current study is designed as a multicenter, randomized and prospective study aiming to compare the effect of PADN on PAH patients. Based on the previous studies, the rate of pulmonary arterial hypertension PAH-related event was around 30 after 6-month treatment using target drugs. And our previous data showed that this PAH-related event at 6-month after PADN procedure was 15. As a result, a total of 270 PAH patients was required, with 135 patientsper group at a ratio of 1:1 randomization. 