 - Significant hepatic, renal or bone marrow dysfunction indicated by: total bilirubin 2.0 mgdL, evidence of bile duct obstruction, serum albumin 2.5 gdL, serum ALT or AST 2.5 x upper limit of normal, serum creatinine 1.5 mgdL, ANC 1.5 x 109L, platelets 100 x 109L, or INR 2.0. 