 Artemisinin combination therapies ACT are currently recommended for malaria treatment. Artemether-lumefantrineA-L and Artesunateamodiaquine AA have been the most commonly adopted of the recommended ACT regimens. In Ghana, AA is the current first-line antimalarial treatment in Ghana, but there has been 1 efficacy report of this regimen in Ghana till date. Moreover, the safety of repeated treatments with ACT has been little studied. This study aims to evaluate the efficacy of AA vs. A-L, as well as the safety of repeated treatments of these regimens in a longitudinal trial in which recruited children will be followed up for 1 year. 