 - Angiographic evidence of a de novo lesion 50 requiring implantation of two DES in overlapping with a total stent length 33 mm and reference vessel diameter between 2.5 and 4.0 mm by visual estimation in one coronary vessel. Multiple lesions in the same vessels can be included but at least one lesion should require implantation of two DES in overlapping with a total stent length 33 mm. The definition of multivessel disease requires an intention to treat at least two lesions with a least one with the characteristics reported above in two different major epicardial segments. For example, the presence of a lesion in the left anterior descending artery and in the obtuse marginal or the presence of a lesions in the right postero-lateral branch and in a diagonal branch will qualify as multivessel. The presence of lesions in the left anterior descending artery and in the diagonal branch will not qualify as multivessel. Bifurcation lesions and ostial lesions can be included, but only if at least two DES in overlapping with a total stent length 33 mm are implanted in the same branch. When treating diffuse lesion in the same vessel, overlapping stenting is recommended with high pressure 14 atm post-dilation of the overlap zone. There is no maximum stent length to treat one coronary vessel. 