 Secondary: Key pharmacokinetic and dialytic parameters were determined as previously described16. The following parameters were recorded: the volume of distribution Vd determined as Vd dose Tempeak - Temtrough in liter; the VdWt in literkg body weight; the non-dialysis clearance of temocillin Kenon-dialysis lnTempeak - lnTempre time between peak level and start of next dialysis; the non-dialysis half-life T12non-dialysis 0.693 Kenon-dialysis in hours; the dialysis clearance of temocillin Kedialysis lnTempre - lnTempost dialysis duration; the dialysis half-life T12dialysis 0.693 Kedialysis in hours; the Urea Reduction Ratio URR BUNpre - BUNpost BUNpre; the Temocillin Reduction Ratio TRR Tempre - Tempost Tempre; the Temocillin Removal Ratio the total amount of temocillin recovered in the dialysate, based on the area under the curve of the temocillin removal rate and the treatment time; and the AUC of temocillin. For all PKPD analysis, the non-compartmental method using RStudio 0.98.501 with R 3.0.2 software was used. 