 Methods The study will include 100-200 patients with ESRD, age 18 years or older, treated in the nephrology division of Assaf Harofeh medical center. Patients will be excluded if their platelets count will be lower then 50,000 cumm, if they have known hematologic malignancies, other solid malignancy with life expectancy of less then 1 year or if they are treated with Warfarin Comadin. Patients will sign a written informed consent before their inclusion in the study. 