 - Satraplatin acts by binding to deoxyribonucleic acid DNA forming intra- and interstrand cross links DNA adducts, resulting in cell-cycle arrest in G2 phase and eventual apoptosis. One of the mechanisms that bring about resistance to platinum-based chemotherapy is removal of the platinum-DNA adducts by DNA repair pathways, called nucleotide excision repair NER and base excision repair BER pathways. 