 - Use of prescription or nonprescription drugs and dietary supplements within 7 days or 5 half-lives whichever is longer prior to the first dose of study medication. Herbal supplements and hormonal methods of contraception including oral and transdermal contraceptives, injectable progesterone, progestin subdermal implants, progesterone-releasing IUDs, postcoital contraceptive methods and hormone replacement therapy must be discontinued 28 days prior to the first dose of study medication. Depo-Provera must be discontinued at least 6 months prior to the first dose of study medication. As an exception, acetaminophenparacetamol may be used at doses of less than or equal to 1 gday. Limited use of non-prescription medications that are not believed to affect subject safety or the overall results of the study may be permitted on a case-by-case basis following approval by the sponsor; 