 - Measurable disease: At least a 20 increase in the sum of diameters of target lesions, taking as reference the smallest sum on study this includes the baseline sum if that is the smallest on study. In addition to the relative increase of 20, the sum must also demonstrate an absolute increase of at least 5 mm. The change will be measured against the best response to castration therapy or against the pre-castration measurements if there was no response. 