 Experimental Plan Subjects. Adult type 2 diabetic individuals ranging from 18-65 yrs, with BMI between 24 and 37 kgm2 and mean hemoglobin A1c levels equal to 6.5 and 9.0 will be studied. A total of 50 subjects will be recruited. There are over 8,000 type 2 diabetic patients under treatment at the TDI with a total of approximately 90,000 visits per year registered in the year 2000. As the main source of diabetes care and education to a population of predominantly Hispanic Americans, the TDI also is responsible for periodic screening in the community. Thus, we do not anticipate any problems in recruiting 50 subjects required for the present study. All patients will be normotensive, free of significant medical problems other than diabetes, and either on diet alone or diet plus sulfonylurea or meglitinides therapy. Subjects who have received or are receiving treatment with a thiazolidinedione TZD will be excluded. We previously have shown that sulfonyureas have no direct insulin sensitizing effect. 