 - .Females of child-bearing potential must have a negative serum pregnancy at within 7 days prior to Cycle 1 Day 1 and must agree to use an effective form of contraception from the time of the negative pregnancy test and for 3 months after the last dose of study drug. Effective forms of contraception include abstinence, hormonal contraceptive in conjunction with a barrier method, or a double barrier method. Females of non-child-bearing potential may be included if they are either surgically sterile, have been postmenopausal for 1 year, or are premenopausal. 