 After randomization, according to current common clinical practice the regimen of phlebotomies must be selected accordingly to maintain the recommended level of HCT 45. Once normalization of the HCT has been achieved, blood counts at regular intervals every 4 weeks will establish the frequency of future phlebotomies. Sufficient blood is recommended to be removed in order maintain the hematocrit below 45. Supplemental iron therapy should not be administered. 