 The incidence of POCD is around 15 in patients aged over 70 years. Despite the lack of data in patients aged 75 years and more the average expected age is around 80 years in this population, the investigators estimate an incidence of 20. Hypothesizing that the proposed intervention intraoperative arterial blood pressure target could cause a 25 relative reduction in the incidence of POCD from 20 to 15 the sample size, for a probability of type I error α0.05 and a power 1-β 0.8 is of 1812 patients. Of note, at the enrolment of 906 patients the Data Safety and Monitoring Board DSMB will perform an ad interim analysis. 