 - time spent by the nursing figure in providing therapeutic education. From societys point of view, the benefits received in the ED and hospitalizations will be assessed according to the charge currently in force in Italy. Indirect costs, represented by the time spent by the patient, and costs related to the time spent by caregivers will be valorized using values published by official sources such as ISTAT. Costs directly charged to the patient will be valued on the basis of the stated cost. Finally, the cost of time spent in educational activities will be assessed using the hourly average cost of a nurse andor doctor in the clinical centers that participate in this study. 