 - For participants assigned to the IVR, IVR2 will be removed at this visit. Post IVR2 use vaginal swabs will be obtained in the clinic. The third IVR IVR3 will be inserted by the participant in the clinic. The participant will leave IVR3 in place until Visit 5 V5, which will occur 28 - 32 days after V4. Participants may have vaginal intercourse not required during the use of IVR3 but should not have any other vaginal activity during the use of IVR3. 