 - Premenopausal and using an acceptable form of birth control. Acceptable forms of birth control include: hormonal contraceptives implantable, oral, patch used for 2 months prior to screening or double barrier methods any combination of two of the following: intrauterine device IUD, male or female condom with spermicidal gel, diaphragm, sponge, cervical cap. All premenopausal females must have a negative urine or serum pregnancy test at screening and on Day 1 prior to first PRTX-100 treatment. 