 Absolute neutrophil count greater or equal to 1,500μl; Platelets greater or equal to 100,000μl; Total bilirubin, less or equal to 1.5 X upper limit of normal ULNASTSGOTALTSGPTless or equal to 2.5 X ULN less or equal to 5 X ULN if known hepatic metastases; Creatinine clearance greater or equal to 50 mLminm2 for patients with creatinine levels by Cockroft-Gault equation or 24 hour urine; Hemoglobin 9 gdL; Magnesium 1.2 mgdL; Calcium corrected for albumin 8.7 mgdL 