 - With the development of specialized devices and experience, off-pump coronary artery bypass OPCAB has been a well-established less invasive technique for coronary revascularization. Compared with conventional on-pump coronary artery bypass grafting CABG, OPCAB avoids the use of cardiopulmonary bypass and cardioplegic arrest, and is associated with decreased morbidity, shorter length of stay in ICU and hospital, and less perioperative complications, especially in elderly patients with severe comorbidities. One-stop also named simultaneous hybrid coronary revascularization is also a novel, safe and feasible minimally invasive approach in selected patients with multivessel coronary artery disease CAD. It allows surgical and interventional procedures to be performed consecutively in the one-stop hybrid operating suite, an enhanced operating room equipped with radiographic capability, wherein the left intramammary artery LIMA is placed on the left anterior descending artery LAD by minimally invasive procedure, immediately followed by percutaneous coronary interventionstenting on the non-LAD lesions. However, few studies are now available on the outcomes of coronary revascularization between the new hybrid strategy with conventional OPCAB. This study is a single center randomized clinical trial to compare 1-year clinical outcomes of one-stop hybrid coronary revascularization with OPCAB in selected patients with multivessel CAD with suitable coronary anatomy. 