 - Exacerbation history: Previously confirmed history of two or more exacerbations requiring treatment with systemic Corticosteroid CS intramuscular, intravenous, or oral, in the 12 months prior to visit 1, despite the use of high-dose inhaled corticosteroids ICS. For participants receiving maintenance CS, the CS treatment for the exacerbations must have been a two-fold dose increase or greater. 