 Resistance exercise associated with partial obstruction of blood flow ischemic exercise is gaining notoriety in the scientific environment, mainly due to strong evidence indicating that such activity can increase strength and muscle hypertrophy, even when performed with low intensity loads. The underlying neuromuscular mechanisms such effects are still partially unknown, and some studies have shown differences in the recruitment of motor units during its execution, and the relationship fatigue-strength after ischemic resistance exercise. Nevertheless, there are still some gaps in the literature regarding the neuromuscular responses during and after unilateral intermittent isometric handgrip protocols to failure in the associated task to partial obstruction of blood flow. 