 When sites with abnormal or suspicious vascular patterns are detected the investigator grade these findings using a visual classification scale adapted from Herth JTO 2009 Zaric Med Oncol 2013 and change to a regular bronchoscope and take biopsies from each site and a biopsy from a normal secondary carina on the contralateral site as control. Finally any other indicated procedures will be performed at the discretion of the local investigator. 