 This study is designed to investigate whether iovera treatment prior to Total Knee Arthroplasty TKA decreases cumulative patient opioid use over the course of 6 weeks following TKA while maintaining similar levels of pain relief. The study will also investigate whether there is a relationship between patients treated with iovera and patient reported pain and function as measured by KOOS JR., NRS for Pain; use of hospital services post-TKA and improved physical rehabilitation as measured by range of motion. 