 2. Within the 3 days of the first dose of study drug: i. Platelet count 75 x 109L; ii. Neutrophil count 1.0 x 109L; iii. Total bilirubin 2 x ULN; iv. Alkaline phosphatase 5 x ULN; v. Alanine aminotransferase ALT and aspartate aminotransferase AST 3 x ULN; vi. eGFR 30 mLmin1.73 m2 