 Imaging MRI imaging will be conducted before the commencement of treatment all subjects and at the end of the active treatment phase where possible. Each subject will undergo a 3D sagittally orientated T1 weighted structural MR scan on the 1.5 Tesla MRI scanner at the Alfred 128 slices. Analysis of scalp to cortex distance in prefrontal cortex and at the site of stimulation will be conducted using previously published methods. This will allow the post hoc analysis of the relationship between scalp to cortex distance and treatment response. In addition, where possible subjects will undergo additional measures of white matter tract integrity diffusion tensor imaging and activation. None of the scanning procedures will involve the administration of contrast. 