 Multiple-dose subjects of moderate dose group finished first step single-dose 30mg trial, one week later, will be repeatedly administered duloxetine 30 mg 7days blood samples 5 mL will be obtained at 4th, 5th, 6th and 7th day before test article administration to test the valley concentrationand at 1, 2, 3, 4, 5, 6, 8, 12, 15, 24, 36, 48, and 72 hours after last test article administration 7th day. 