 - Alkaline phosphatase AP 2.5 x upper limit of normal ULN andor aspartate aminotransferase AST, SGOT, alanin aminotransferase ALT, SGPT 2.0 x ULN or AP, AST andor ALT 3 x ULN in case of liver metastases; γ-glutamyl transpeptidase GGT 5.0 x ULN 