 Crohns disease CD is a chronic, refractory inflammatory bowel disease that affects the entire digestive tract associated with intestinal and extra intestinal manifestations or other autoimmune diseases. Conventional therapy to Crohns disease isolated or combination of anti-inflammatory, immunosuppressant and or biologic drugscorticosteroids. This treatment beneffit the majority of patients. However, a proportion of patients fail to achieve complete and long term disease control and often require multiple intestinal surgeries with a risk of developing short bowel syndrome. 