 Picato ingenol mebutate gel is a new topical therapy for Actinic Keratosis AK in adults which was approved by the Korean Ministry of Food and Drug Safety MFDS in December 2013. For AK in face or scalp the 0.015 percent gel is approved to be applied once a day for 3 consecutive days, and for AK in trunk or extremities the 0.05 percent gel is approved to be applied once a day for 2 consecutive days. 