 - Gastrointestinal disease or disorder that could interfere with the swallowing, oral absorption, or tolerance of CUDC-907. This includes uncontrolled diarrhea 1 watery stoolday, major abdominal surgery, significant bowel obstruction andor gastrointestinal diseases that could alter the assessment of pharmacokinetics or safety, including but not limited to: irritable bowel syndrome, ulcerative colitis, Crohn s disease and hemorrhagic coloproctitis. 