 Type II EC is not estrogen-dependent and of serous or clear cell histology. In contrast to type I cancers, the vast majority, especially of serous cancers, are high grade, affect postmenopausal women, do not cause early symptoms, are diagnosed at an advanced stage, behave more like epithelial ovarian cancer EOC and have a very poor prognosis. Precursor lesions in the endometrium are referred to as serous endometrial intraepithelial carcinoma SEIC, lesions quite similar to the precursor lesion of EOC in the fallopian tube, called serous tubal intraepithelial carcinoma STIC. 