 The primary objective is to show that change of strain echocardiography parameters between after 240mgm2 and baseline is associated with the 1-year event rate of the primary endpoint. Based on existing literature, the overall 1-year event rate is about 8 in the targeted cancer population. We projected that 30 of the population will experience deteriorated echocardiography parameters the risk group and the rest 70 the normal group will have stable values on these parameters. Previous studies have shown that the normal group very close to zero event rate. Assuming that the event rate for normal group is 3 and thus the event rate for the risk group is 20, a total of 128 subjects allows us to have 85 power to detect the difference with type I error rate one-sided is controlled at 0.05. Alternatively, if the overall event rate is as low as 5 with 1 in the normal group and 15 in the risk group, using χ2 test we will still have 85 power to detect the difference. With 15 attrition rate, we will recruit 1280.85150 patients. With a projected enrollment of 6 patients per month, we anticipate the recruitment period to be 25 months. 