 AS902330 is expected to increase the production and development of specific bone cells: chondrocytes and osteoblasts cells that produce and maintain bone and cartilage. This is expected to lead to repair and generation of the cartilage, and a narrowing of the space width between the knee joints in a selected region of the knee cartilage. The purpose of this study is to see how safe treatment with AS902330 is, and to evaluate its effect on the knee cartilage. In addition, the study will also measure the effects of AS902330 in the blood, which reflect disease activity. 