 - Symptomatic or untreated leptomeningeal or brain metastases or spinal cord compression; patients with treated and stable brain metastases will be allowed; controlled brain metastases are defined as no radiographic progression for at least 4 weeks following radiation andor surgical treatment or 4 weeks of observation if no intervention is clinically indicated, and off of steroids for at least 2 weeks, and no new or progressive neurological signs and symptoms 