 This proposed, single-subject, or N-of-1 study design will involve longitudinal data collections i.e., repeated samplings on the TP53 carrier to detect likely health-informative changes over time. We emphasize that many of the biomarkers and biometrics to be studied have the potential to detect cancer, but may also simply provide indications of health status changes generally and as such we envision the proposed study as one focusing on the prototyping and implementation of a system for monitoring biomarkers that may detect tumor formation or indicate health status changes that could warrant further scrutiny. 