 14. Hormone Receptor negative and not received neoadjuvant chemotherapy 15. Use of hormone replacement therapy within the last 6 weeks 16. Pregnant or lactating women or women of childbearing potential unwillingunable to use non-hormonal contraception 17. No previous or concomitant malignancies except adequately treated squamous cell basal cell carcinoma of the skin, in situ carcinoma of the cervix or ductal carcinoma in situlobular carcinoma in situ of the breast, unless there has been a disease-free interval of 10 years or more 18. Psychiatric or addictive disorders which could preclude obtaining informed consent 19. Clinical evidence of severe osteoporosis andor history of osteoporotic fracture 