 During liver resection high serum lactate sLac concentration can be related to several clinical factors: impairment in lactate metabolism i.e. extraction and utilization by the liver or overproduction by splanchnic tissues; restrictive fluid regimen in order to limit the intraoperative back-flow bleeding; ischemia-reperfusion syndrome. However, the Pringle maneuver temporary clamping of the hepatic hilum seems having a sensible effect in inducing a significant increase in sLac levels during liver resection, particularly in the event of compromised liver function such as in cirrhosis. 