 The proposed protocol aims to combine functional magnetic resonance imaging fMRI and SPEM eyetracking measures to study 1 the neural circuit controlling the psychophysical, cognitive, and oculomotor aspects of eyetracking; 2 the underlying neural mechanism of schizophrenia-related eyetracking impairments; and 3 the degree to which pursuit-related imaging changes aggregate in families. The human eye movement system is complex. It is likely that only components of the system, rather than the whole system, are involved in the pathology of schizophrenia. 