 Significant lesions in small coronary arteries are frequently found 35-50 in patients with coronary artery disease. Independently of the type of coronary angioplasty the restenosis and the need for repeat revascularization remains the main limitation, representing a challenging problem even in the DES drug eluting stent era. Recently has been developed drug eluting balloons DEBs, which have been successfully tested in small series on in-stent restenosis, but few evidence is available in the context of small vessels disease. 