 6. plan to take systemic anti-tumor therapy within 4 weeks before grouping or during the medicine-taking period of this research, including Cytotoxic Therapy, Signal Transduction Inhibitor, and Immunotherapy or who use Mitomycin C within 6 weeks before taking the treatment with experimental drug; The patients who have already taken Extended Field Radiotherapy EF-RT within 4 weeks before grouping or Limited Field Radiotherapy with proposed assessment of nidus within 2 weeks before grouping 