 A novel system has been developed by Dr Douglas Morrison, Scottish Universities Environmental Research Centre SUERC. This molecule of inulin β2-1 linked polymer of fructose carrier with an ester linked to propionate propionate ester was demonstrated to reliably and reproducibly increase colonic propionate while prevent the side effects of NDC Chambers et al. 2015. Thus, propionate is only released when the carrier molecule inulin is fermented by colon microflora, which was estimated to be 180 minutes post-ingestion. Chambers et al. 2014. Chambers et al. 2015 were able to show that 10g of Inulin-Propionate Esters IPE has the ability to deliver 2.4g of propionate to the colon, that is an increment of 2.5-fold of propionate production in the colon, a level that is achieved only with 60gd via traditional dietary fibre supplementation. The same group has also demonstrated that while the acute administration of this supplement caused increments in Plasma GLP-1 and PYY and reduced food ingestion, the long term 24 weeks supplementation of propionate ester significantly reduced body weight gain and the development of abdominal adipose tissue Chambers et al. 2014. Interestingly, none of the long term participants reported any side effects from the intake of propionate esters. Increasing colonic propionate is, therefore, one of the attractive strategies to manage weight and diabetes risk factors. 