 6. Adequate organ function: total bilirubin 2 times upper limit of normal x ULN 3 x ULN if considered to be due to leukemic involvement or Gilberts syndrome; aspartate aminotransferase AST or alanine aminotransferase ALT 2.5 x ULN 5.0 x ULN if considered to be due to leukemic involvement; serum creatinine 2 x ULN, amylase and lipase 2 x ULN . 