 3. Minimum body-surface area BSA of 1.4 m2 at point of recruitment. This is a safeguard against recruiting small-built patients who may experience adverse reaction on absolute dosing of oral vinorelbine. At this body surface area, the maximum dosing of oral vinorelbine at 120 mgweek is equivalent to 86 mgm2week for a patient with BSA of 1.4 m2. 