 - Female subjects of childbearing potential who agree on using double-barrier contraception during the study. If a female is postmenopausal no menses for at least 2 years or surgically sterile bilateral tubal ligation, bilateral oophorectomy, or hysterectomy she will be exempt from the requirement. In case of using oral contraceptives, these should be withdrawn at least 2 months before the first drug dosing. 