 - CLL will be diagnosed if these cells have 3 of the following characteristics: CD5, CD23, dim surface light chain expression, dim surface CD20 expression, AND FISH analysis is negative for IGHCCND1 andor immunostaining is negative for cyclin D1 expression to exclude mantle cell lymphoma Previous treatment for CLL Progressive disease: symptomatic CLL weight loss10 within 6 months, extreme fatigue, fevers38.5 C, drenching night sweats without evidence of infection OR evidence of progressive bone marrow failure hemoglobin11gdL, platelet count100 x 109L OR massive 6 cm below left costal margin or progressive palpable splenomegaly OR massive 10 cm or measurable and progressive lymphadenopathy 