 Primary clinical outcome is cure Adequate Clinical and Parasitological Response - ACPR on Day 28 and 42. Secondary outcome measures are time until parasite, fever, and gametocyte clearance PCT, FCT, and GCT. Parasite genotyping will be used to distinguish recrudescences from reinfections by PCR for patients in whom recrudescences cannot be fully excluded. Subjects will be monitored for clinical adverse events throughout the study duration. 