 In addition to collecting microbiological response, clinical response data will be used for all patients. Successfavorable clinical response will be defined as all or most of pretreatment signs and symptoms of the index infection have resolved or improved e.g.: TPR shift toward normal and no additional antibiotic therapy or switching of regimen was required. While failure will be defined as no apparent response to therapy; persistence or progression of mostall pre-therapy signs and symptoms and additional antibiotic therapy or switching of regimen was documented. 