 - History of cardiac disease: congestive heart failure New York Heart Association NYHA Class II, unstable angina anginal symptoms at rest, new-onset angina within the past 3 months prior to the first dose of study drug, myocardial infarction within the past 6 months prior to the first dose of study drug, or cardiac arrhythmias requiring anti-arrhythmic therapy beta blockers or digoxin are permitted 