 Platelet inhibition ratio assessment by thrombelastogram will be performed,2 hours after the loading doseDay 0, 6 hours after thrombelastogram Day 0, 30 day after thrombelastogram. Documentation of major adverse cardiac events death, myocardial infarction, stroke, revascularization procedure with PCI or CABG and serious adverse events bleeding, other adverse eventswill be performed until Day 30. 