 Family history is a well known risk factor for early atherosclerosis. Whether inflammation plays a role in the increased risk of family history is not known. In this prospective single-center study, we are recruiting children with and without a family history of premature atherosclerotic disease, defined as occurring 55 years in males and 65 years in females. Children are recruited primarily from a pediatric preventive cardiology clinic at Childrens Hospital Boston. We measure anthropomorphic characteristics, fasting lipid profiles and inflammatory marker levels, including high sensitivity C-reactive protein hsCRP, intracellular adhesion molecule 1 ICAM-1, P-selectin, and tumor necrosis factor alpha receptor 2 TNFαR2. 