 b.Emergence of symptom, dosing, and initiation of treatment: Withdrawal is defined as at least 2 NAS scores 8 or 1 NAS score 12. Once withdrawal has emerged, the infant will be given: i. Phenobarbital 20 to 30 mgkg to load divided in up to 3 doses over 24 hours and maintenance phenobarbital should be started at 2.5 mgkgdose administered Q 12h, 12 hours after the loading dose is ended. NAS scoring is continued and if scores remain 8 for a minimum of 5 days after starting phenobarbital, the infant is eligible for discharge. 