 Weight gain and sedation have been postulated to be associated with the blockade of central nervous system CNS histamine-1 receptors H1 by the atypical agents Heisler 1998; Wirshing et al. 1999. In light of this postulated mechanism, it is reasonable to assume that overcoming the H1 blockade with a histamine agonist may aid in reducing these side effects to a tolerable level. Thus, the following study is proposed. 