 On Days 1, 2, 5 and 15, pharmacokinetic PK and pharmacodynamics PD sampling will be performed 30 minutes prior to the first dose, and 0.5, 1, 2, and 4 hours after the first dose at all visits with an additional PK draw on Day 1 at 0.5, 1, 2, and 4 after the second dose. Urine for PKPD will be collected pre-dose on Day 1, Day 2, Day 5 and Day 15. At all visits on Days 1, 2, 5 and at the final dose on Day 15, samples will be collected for chemistry, Complete Blood Count CBC, International normalized ratio INR, prothrombin time PT, partial thromboplastin time PTT, cholesterol, low density lipoprotein LDL, and high density lipoprotein HDL, and vitamin K level. Blood samples for PKPD will be collected 30 minutes prior to the morning dose on Day 5 and Day 15 and also at 0.5, 1, 2, and 4 hours after dosing. Lab samples chemistry, etc., will also be drawn at the time of the first PKPD draw on Day 5 and Day 15. 