 The three-year pioneering project will begin with observing the psychosocial characteristics and demographic profile of a group of patients with depressive disorders and a sub-group of TRD cohort, followed by validating the cultural meanings and recovery constructs of TRD through professional and lay focus groups. In the second to third year, we will examine the effectiveness of a 6-week, nurse-led psychosocial intervention with group approach in a randomized control trial RCT compared to the controls receiving usual care with follow-ups. Detailed psychiatric assessment and study interviews will be performed at baseline, 3, 6, and 9 months after the intervention by a senior psychiatrist and a research assistant using standardized operation forms.Structured measurements will be utilized to collect primary outcome variables of psychological distress, suicide risk and resilience as well as secondary outcome measures of quality of life, community reintegration level, perceived satisfaction, and main clinical variables e.g., treatment adherence, service use such as EROPD attendance or hospitalization days. The control group receives usual care of pharmacological therapy provided by the psychiatrists in the Psychiatric Department. 