 Initially, a Phase I will be conducted using a modified 33 dose-escalating algorithm. The first three patients will be enrolled in the first dose level see Figure 1 for dose escalation levels. If no DLT occurs among them, the next cohort of three patients will continue at the next higher dose level. If a DLT occurs among the first three evaluable patients during the first cycle, three more patients will be enrolled at the same dose level. 