 The aim of this study is to determine the effects of vitamin D or placebo for 3 months on the gene expression of plasma human cartilage glycoprotein 39YKL40, receptor for advanced glycation end products RAGE and glyoxalase enzyme in the peripheral blood mononuclear cell PBMC and serum levels of YKL40 ,plasminogen activator inhibitor-1 PAI-1, TNF-α, advanced glycation end products AGEs , IL-6, and HbA1c of diabetes type 2 patients. 