 The sample size calculation was performed in Sealed Envelope TM program. 156 patients will be needed 78 per group, using the following indicators: confidence level 95, 5 maximum error permitted, statistical power of 90 for detecting elevation of the primary endpoint by 12 in the experimental group. After applying the inclusion and exclusion criteria, two groups will be sourced from the randomization and will be allocated into case group and control group without replacement. All subjects included will be assigned a three-digit sequential number eg. 000-999. These numbers will be fed into groups of four patients with similar characteristics. After that, blok size randomization will be procedure in specific software 