 IV acetaminophen OFIRMEV is indicated for management of mild to moderate pain, and as an adjunct to opioids for severe pain. Several studies have examined the efficacy of IV acetaminophen vs placebo andor active controls meperidine, rectal acetaminophen PR, tramadol. IV acetaminophen has been shown to be superior to placebo for pain control. Though there is data regarding peak plasma and Cerebral Spinal Fluid CSF concentration of acetaminophen when given by different routes PO vs IV vs PR, there is no data comparing the efficacy of oral vs IV administration for pain control post-tonsillectomy in children. 