 Individualized fortification is another method recommended for optimizing breast milk fortification, and it is considered the best solution for addressing the protein deficiencies of VLBW preterm infants 10, 12. There are two valid methods of individualized fortification: targeted fortification based on analyses of breast milk proteins, and adjustable fortification based on the blood urea nitrogen BUN - reflected metabolic response of infants 10, 12. Despite these developments, there is still no consensus on the optimum fortification method; many different protocols are applied in NICUs worldwide 20, 21. 