 Bio Bank Biological samples will be coded in compliance with Tri Council Policy Statement criteria: direct identifiers will be removed and replaced with a unique study code that does not use personal information such as the participants birth date, health number, social insurance number or nameinitials. The coded biological samples will be stored in the James Hogg Research Centre at St. Pauls Hospital in Vancouver, British Columbia. The coded samples will be linked to the master list kept securely in the research office of the collaborating site investigators. Only site investigators and their local research staff will have access to the master list. 