 - Sustained or clinically significant cardiac arrhythmias including sustained ventricular tachycardia, ventricular fibrillation, clinically significant bradycardia, advanced heart block Mobitz II or higher atrioventricular nodal block, prolonged heart rate-corrected QT interval longer than 470 milliseconds, or history of acute myocardial infarction. The QT interval is the time between the start of the Q wave and the end of the T wave in the cardiac electrical cycle 