 5. Patients must have adequate hepatic,renal, bone marrow function,defined as the following:1 total bilirubin 1.5xULN;2 serum glutamate oxaloacetate transaminase SGOT serum glutamate pyruvate transaminase SGPT2.5xULN;3creatinine 1.5xULN;4 ANC 1.5x109L;5 platelets100 x 109L.Note:Renal function is only based on serum creatinine level 1.5xULN.The standard Cockcroft Gault formula or the measured glomerular filtration rate GFR using the appropriate radio labelled method 51-CrEDTA or Tc99m-DTPA must be used to calculate cranial cruciate ligament CrCl for enrollment or dosing.The same method used baseline should be used throughout the study.CrCl should be 45mgdl. 