 3. Subjects who have encephalopathy greater than Grade 2, sepsis, or gastrointestinal bleeding within 1 month before the Screening Period; esophageal varices greater than Grade 2, acute hepatic failure of any etiology, history of surgical portosystemic shunt, renal impairment creatinine clearance lesser than 50 mLmin according to the Cockcroft-Gault formula, and rapidly deteriorating hepatic function indicated recently by clinicallaboratory signs of hepatic impairment within 2 months prior to the Screening Period. 