 The patients clinical data over a 72 hour period after enrolment will be recorded in the CRF. The enrolment sample will then be retrospectively measured for the HBP level and the power of the enrolment HBP level to predict subsequent clinical development over the following 72 hours will be assessed. Data analysis shall include Area Under Curve AUC from Receiver Operating Characteristics ROC plot against the patients final clinical diagnosis as well as sensitivity and specificity of the HBP level to predict the final clinical outcome. 