 1. Data will be collected from the participating hospitals by one study medical doctor. Together with the principal investigator she has access to the source data which are coded by a case number. The key to the code is safeguarded in the safe from the TweeSteden hospital, Tilburg, The Netherlands. Data and human material will be kept for seven years or fifteen with patient consent. Data security is assured by the fact that one medical doctor collects the data. The privacy of the participants is protected by the fact that the data is coded. 