 The specific aim of this proposal is to extend the current longitudinal investigation into the preschool age group 1 to 5 years of age. The developmental profile of CYPs, 1A2, 2D6, and 3A4 will be determined by caffeine and dextromethorphan phenotyping procedures. The purpose of this study is to determine the agedevelopmental stage at which the CYP2 1A2, 2D6 and 3A4 activities exceed adult activities. 