 All subjects then have a 2-week washout period. After the washout period, subjects will be crossed over to the opposite arm in which the same patterns of outcome assessment and dose titration were maintained. The study will conclude at 20 weeks. At the end of 20 weeks Visit 2, the investigators subjects will be interviewed about any side effects, vital signs will be examined, adverse reactions or events monitored, and outcome measures will be documented. Throughout the study, the subjects will be able to drop out anytime with instructions to inform us of their decision and about any adverse effects. Overall, each subject will have 3 clinical visits after enrollment in the study. 