 8. Prior chemotherapy or biological treatment is allowed, but any active oncological treatment should be stopped at least 6 days prior to radiation and renewed at least 6 days following radiation. For trastuzumab emtansine a 14 break prior to, and a 6 day break post-therapy is required. Hormonal treatments e.g. tamoxifen, androgen ablation, androgen antagonists, aromatase inhibitors, and bone-strengthening agents e.g. bisphosphonates, anti-RANKL antibody denosumab may be continued during the radiation treatment, and do not need to be interrupted. 