 Study design and treatments The study was randomized, double-blind, controlled, using a 2-way crossover design with both treatment periods and washout time lasting 7 days. Subjects were allocated by simple randomization to extended-release niacin 1gday alone ERN, Metri, Libbs Farmacêutica, São Paulo, Brazil or niacin associated with LRPT 1g20mg ERNLRPT, Cordaptive, Merck, São Paulo, Brazil. Medications were kindly supplied by Libbs and Merck. Plasma samples and brachial artery reactivity were obtained at baseline, 7th day of treatment 1, 7th day after washout and 7th day of treatment 2. 