 Patients are treated by regular CVVHDF setting in pre-dilution mode. The replacement flow-rate for the citrate replacement fluid depends on the blood pump speed fixed ratio, see 9.3 and table below. Mean dialysate flow is between 100 mlhr and 2500mlhour in accordance to the desired base-equivalent intake. Access pressure is kept between -100 and 150mmHg. Access and return pressure are monitored. Specially formulated replacement- and dialysate fluids are used. 