 - Coagulation parameters international normalized ratio INR, activated partial thromboplastin time aPTT 1.25 x institutional limits, except where a lupus anti-coagulant has been confirmed; patients on full dose anti-coagulation must be on a stable dose for at least 14 days; if receiving warfarin, the patient must have an INR 3.0 without any evidence of active bleeding within 14 days prior to first dose of study treatment or a pathologic condition that carries a high risk of bleeding tumor involvement with major blood vessels or varices 