 - Has a new lobar pulmonary infiltrate or a diagnosis of acute chest syndrome i.e., a new lobar pulmonary infiltrate and two or more of the following: temperature greater than 38oC, tachypnea, dyspnea, intercostal or supraclavicular retractions, nasal flaring, chest wall pain, and an oxygen saturation of less than 90 in room air by pulse oximetry 