 8. Patients must have adequate organ function, as defined by the following parameters: a. Bone marrow: Absolute Neutrophil Count ANC greater than or equal to 1.5 x 109L; Hemoglobin Hgb greater than or equal to 9 gdL; Platelets greater than or equal to 100 x 109L. b. Hepatic function: Serum total bilirubin less than or equal to 1.5 x upper limit of normal ULN; Aspartate aminotransferase AST serum glutamic oxaloacetic transaminase SGOT and ALT SGPT less than or equal to 2.5 x ULN, except in patients with tumor involvement of the liver who must have AST and ALT less than or equal to 5 x ULN. 