 2. Target Population: a. Men and women 18 years of age. b. Eastern Cooperative Oncology Group ECOG performance status of 1. c. Subjects with histologically- or cytologically-documented incurable Human Papillomavirus HPV-16 positive solid tumors including oropharyngeal squamous cell carcinoma OPSCC, cervical, vulvar, vaginal, anal, penile cancer. Incurable HPV-16 solid tumors are defined as tumors which are not curable by salvage approaches including resection andor re-irradiation. HPV-16 serotype will be assessed by Cervista assay. 