 On 26th September 2012, on advice from an independent senior statistician who reviewed the actual event rate in the control arm, the rates of recruitment and loss to follow up, the Trial Steering Committee recommended that the trial team to recruit at least 1750 participants to achieve the original objective of having 90 power to detect a reduction in mortality during 12 months follow up of 33. Recruitment was stopped on 31st March 2013 at 1781 participants. 