 - Adequate baseline organ functions, defined as follows: Serum creatinine 1.5 × upper limit of normal ULN. In case of borderline values for serum creatinine, creatinine clearance must be 45 mLmin; Total bilirubin 1.5 × ULN; Alanine aminotransferase ALTaspartate aminotransferase AST 2.5 × ULN Subjects with liver metastases should have ALTAST 5 × ULN.; Absolute neutrophil count 1500mm3; Platelet count 100,000mm3; Hemoglobin level 10 gdL11 