 Current standard of care for treatment of locally advanced unresectable stage II and all of stage III non-small cell lung cancer NSCLC is chemo-radiation which consists of 7 weeks of radiation and chemotherapy given at a reduced dose as opposed to systemic dose when chemotherapy given by itself. While outcomes have improved over time they remain humbling, with current approaches associated with overall poor results both in terms of local 30 of patients have local failure and distant control 40 of patients have distant failure with a median overall survival of 17 months. 