 Healthy controls n 100 and patients with suspected SPAD n 100 will be immunized with both Pneumovax 23 and Typhim Vi age 18 months - 55 years. Analyses of anti-pneumococcal polysaccharide antibodies and anti-Vi antibodies are performed before and 3-4 weeks after vaccination. Also bloodgroup and anti-Aanti-B are assessed. Relevant clinical information ENT infections, lung infections, bronchiectasis, invasive infections is obtained from the patient file and history and is noted in a Case Report Form. 