 - Patients must meet at least 1 of the following laboratory criteria: White blood cell count 4,000 × 109L OR 20,000 × 109L; Immature to total neutrophil ratio 0.2; Platelet count 100,000 × 109L; C-reactive protein CRP 15 mgL OR procalcitonin 2 ngmL; Hyperglycaemia OR Hypoglycaemia; Metabolic acidosis. 