 While their chemotherapy had been administered up till then at the classical regimen of Maximal Tolerated Doses MTD, which is aimed to directly killing maximal fractions of tumor cells, the present study evaluates the clinical benefit of a treatment which is based on old chemotherapeutic and old anti-inflammatory drugs, when these are administered at low doses,on daily basis and orally taken, without planed brakes Low Dose Metronomic regimen. 