 Half the MS patients require a natural non professional caregivers support for daily living activities and this level of investment increases with the degree of disability. Authors considered that an approach focused on the caregivers burden limits the perception and evaluation of the real impact of hisher role at the patients side, just as it probably limits the effectiveness of interventions used and the support they can be offered. According to them, the concept of QOL linked to the disease of the assisted person would be better adapted to respond to this question, because of its multidimensional approach, along with the potential secondary benefits of caregiving. 