 Prompt electrical defibrillation electrical shocks is the treatment of choice in persons who develop SCD due to ventricular fibrillation VF or pulseless ventricular tachycardia pVT. However, in up to 25 of all cardiac arrests, patients develop shock resistant VF, defined as VF persisting beyond three defibrillation attempts, and 87-97 of these patients die. Medical therapy, including antiarrhythmic agents, sympathomimetic agents i.e. stimulants, and buffers have been relegated to a secondary role since there is little evidence that they are of benefit and there use is considered indeterminate or class IIB. Furthermore, the Guidelines 2000 for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care of the American Heart Association and the International Liaison Committee on Resuscitation recommend antiarrhythmic drugs as acceptable and probably helpful in the treatment of VF that persists after three or more external defibrillation shocks. It has been previously reported that the survival rate of hospital patients suffering a cardiac arrest in which epinephrine was required was only 6. Furthermore, Dorian et al reported a survival to hospital admission of 22.8 in patients suffering an out of hospital cardiac arrest and receiving amiodarone. It is believed that the acute effects of amiodarone are due to the class II or beta blocking effects of the drug. 