 Specific therapeutic options are surgery, chemotherapy, conventional fractionated whole-brain radiotherapy WBRT and radiosurgery. Radiosurgery allows delivering of a single high dose fraction of radiation to targets of 3-3.5 cm maximum diameter. In patients with newly diagnosed brain metastases, a rapid decrease of symptoms, local tumor response rate of 73-90 and a median survival of 7-12 month have been reported. 