 - Biochemical values within the following limits: a Alanine aminotransferase ALT and aspartate aminotransferase AST 3.0ULN; b Total bilirubin 1.5ULN unless due to Gilberts syndrome; c Serum creatinine 1.5ULN or a calculated creatinine clearance of 50 milliliter per minute per 1.73 square meter 