 - Abnormal Electocardiogram ECG: Clinically significant abnormal ECG finding at Visit 1. Significant is defined as: Corrected QT QTc 450 milliseconds msec or QTc 480 msec in subjects with Bundle Branch Block. The QTc is the QT interval corrected for heart rate according to Bazetts formula QTcB, Fridericias formula QTcF, andor another method, machine-read or manually over-read. The specific formula that will be used to determine eligibility and discontinuation for an individual subject should be determined prior to initiation of the study. In other words, several different formulae cannot be used to calculate the QTc for an individual subject and then the lowest QTc value used to include or discontinue the subject from the trail. 