 The key outcome variable of this clinical trial is the dental plaque level the key reservoir for oral pathogens. In a previous observational study we conducted among stroke survivors, the mean PI score was 2.1 standard deviation SD0.51 at discharge and 1.9 SD0.56 at 6 months, yielding a change score of 0.21 SD0.46. On the basis of this study, and proposing a difference in plaque change scores of at least 0.3 between baseline to follow-up and also between groups and with the standard deviation set at 0.46, then the number of study subjects that would be required is 38 per group, based on 80 power and the statistical significance level set at 0.05. Anticipating a 20 dropout rate over the course of the clinical trial, the initial sample size for each treatment group is proposed as 47 patients per group 94 subjects in total. 