 2. ALT and AST and Alkaline Phosphatase 2.5 X upper normal limit , although in patients with liver metastases these are acceptable if 5 X ULN; 11. Adequate renal function serum creatinine: 1.5 X ULN. 12. Absence of any non-hematological toxicity at grade 2 or higher. 13.The patient is able to understand and ready to sign the informed consent 