 This randomized, double-blind, placebo controlled study will involve 600 healthy Glucose-6-Phosphate Dehydrogenase G6PD normal volunteers. Participants who meet the eligibility criteria will be randomized ratio 1:1 to receive a loading dose of either tafenoquine 200 mg 2 x 100 mg tablets or placebo daily for three consecutive days, followed by study treatment tafenoquine 200 mg or placebo once per week for 51 weeks, with safety follow-up visits at Weeks 4, 12, 24, and 52. All participants will return to the clinic at Week 64 for an end of study visit. If the participant has an ongoing AE at the Week 64 visit will continue to be assessed for up to 3 more times at approximately 12-week intervals or until resolution or stabilization of the AE whichever is earlier. 