 Weight gain is a common phenomenon among breast cancer patients receiving adjuvant chemotherapy 10 as well as receiving adjuvant anti-hormonal therapy 11. While sufficient physical activity and limitation of the amount of weight gain is important for all breast cancer patients, it surely is for overweight and obese patients. In the provinces of Groningen and Drenthe, the percentage of overweight women is significantly higher compared to the national average. In addition, in this area the average socio-economic status SES, often associated with unhealthy lifestyle, overweight and not seeing the personal relevance of health recommendations, is lower than in the rest of the Netherlands. This leaves this group extra vulnerable for all kinds of health problems like diabetes mellitus, hypertension, increased risk of cardiovascular disease and decreased cancer related survival. However, it is also known to be a population that is very difficult to motivate to engage in more physical activity. Therefore, it is uncertain if the guideline oncological rehabilitation is sufficient enough to reach the NNGB goals. Oncological rehabilitation can render health gain in this patient population, as it can potentially limit weight gain, improve parameters of metabolic syndrome and improve health-related quality of life. 