 Inclusion Criteria: -at least 18 years old - Diagnosis of chronic kidney disease CKD and receiving dialysis for at least 3 months prior to screening - Baseline Hb level greater than or equal to 10.0 gdL and less than or equal to 13.0 gdL - Adequate iron stores defined as serum ferritin greater than or equal to 100 μgL or transferrin saturation TSAT greater than or equal to 20 - Stable IV epoetin alfa or beta or SC rHuEPO epoetin beta therapy 2 or 3 times per week for at least 8 weeks before screening stable is defined as less than 25 change in weekly dose and no change in frequency or route - All subjects must practice adequate contraception in the judgment of the investigator throughout this trial. Exclusion Criteria: - Received SC epoetin alfa in the 12 months before screening - Uncontrolled hypertension diastolic blood pressure greater than 100 mmHg or systolic blood pressure greater than 180 mmHg on 2 separate occasions during screening - Prior history within 12 weeks before enrolment of cardiovascular events including: 