 - 1. Allergic to apatinib; 2. Have high blood pressure and antihypertensive drug treatment can not control systolic blood pressure 140 mmHg, diastolic blood pressure 90 mmHg, with classIIand above coronary heart disease and arrhythmia including QTc lengthened men 450 ms, women 470 ms and cardiac insufficiency; 3. A variety of factors influencing oral drugs such as unable to swallow, nausea, vomiting, chronic diarrhea and intestinal obstruction, etc.; 4. Patients with tendency of gastrointestinal bleeding, including the following; 