 8. All patients must have measurable disease per RECIST version 1.1 defined as at least one target lesion that can be accurately measured in at least one dimension 10 mm longest dimension to be recorded; Lymph nodes must be 15 mm per short axis. Each lesion must be 20 mm when measured by palpation or conventional imaging techniques CT or MRI - based on primary physician preference or 10 mm with spiral CT scan. Measurable lesions must be at least 2 times the slice thickness in millimeters. Tumors within a previously irradiated field will be designated as non-target lesions unless progression is documented. Ascites and pleural effusions are not considered measurable disease. If the measurable disease is confined to a solitary lesion, its neoplastic nature should be confirmed by cytologyhistology. 