 The second study focused on measuring the three miRs in BM samples taken from B-ALL patients at diagnosis treated by the BFM protocol. ProALL miRs predicted high risk to relapse p0.0001, n127. ProALL miRs were found to be an independent predictor when tested with prognostic factors known at diagnosis and when tested with PCR-MRD. Similar findings were found for patients treated by the DCOG protocol n32, p0.0001. In a small feasibility study the investigators showed that ProALL miRs measured in blood correlated with ProALL miRs measured in bone marrow Avigad et al. Mir Expression Profile of Peripheral Blood Lymphocytes Predicts Relapse in Pediatric Acute Lymphoblastic Leukemia. Blood. 2016;128:1736 - Poster presentation at ASH 2016. 