 Hypercholesterolemic patients either with or without a history of statin intolerance 1:1 ratio will be randomized to receive once daily by mouth capsules containing either ETC-1002, ezetimibe, or ETC-1002 ezetimibe. This study will explore the safety and efficacy of concomitant administration of ETC-1002 and ezetimibe, while also exploring the effect of ezetimibe on ETC-1002 systemic exposure. 