 - Adequate renal and hepatic function, defined as: Total serum bilirubin 1.5 x ULN for the institution; AST andor ALT 3 x ULN for the institution 5 x ULN if liver metastases are present; Serum albumin 2.5 gdL; Serum creatinine 1.5 x ULN for the institution or a calculated creatinine clearance 50 mLmin1.73m2 