 - Any of the following cardiac abnormalities: unstable angina pectoris, including Prinzmetal variant angina, New York Heart Association NYHA Classification for Congestive Heart Failure Grade III or greater, myocardial infarction or stroke 12 months prior to study treatment, long QT syndrome, baseline 12 lead ECG QTc of 450msec per central evaluation, history of sustained ventricular tachycardia, history of ventricular fibrillation or Torsades de Pointes, right bundle branch block and left anterior hemiblock bifascicular block, bradycardia 50 beats per minute 