 Symptoms will be identified with an advanced set of diagnostic tests. In perspective, the aim is to develop a non-pharmacologic therapeutic strategy, which could be easily applied in the clinical practice by the structures of the National Health Service. The presence of a protocol of physical training allows also to improve knowledge about the relationship between cardiovascular and cerebral fitness in conditions of cognitive decline, an aspect virtually unexplored and absent from the current medical literature. Recent studies highlight that vascular damage and systolic hypertension in MCI subjects represent a risk factor for progression into overt AD, but also suggest that these alterations are an ideal target for secondary prevention. When the study is completed, it will be possible to discern if the chosen program of physical exercise and cognitive stimulation has been able to reduce, to a statistically significant degree, the progression of cognitive decline, as measured with neuropsychological tests, and brain damage, evaluated with morpho-functional techniques, in subjects with ADVD in the intervention arm as compared to a control group. If this is the case, the combined physicalcognitive intervention procedure will be proposed as non-pharmacological preventive and therapeutic strategy. A final follow-up evaluation, seven months after the end of the intervention, will provide information about the duration of the effects. 