 3. Failure to treatment: Failure to at least 2 NSAIDs at maximum recommended dose during at least 3 months or a shorter time in case of intolerance, toxicity or contraindication.In cases of ankylosing spondylitis with peripheral joint involvement, salazopyrine should have been used at a dose of 2-3 g per day andor methotrexate 15 mgweek for 4 months or a shorter time in case of intolerance, toxicity or contraindication. In case of oligoarticular or localized involvement in enthesis: lack of response, at the discretion of the investigator, to local infiltrations andor synoviorthesis. 