 The Mini Mental State Examination MMSE and the Clock Drawing Test will be used to assess the cognitive state of the patients. The MMSE is usually employed in clinical practice for two reasons: i as a quick tool to screen the cognitive status of the patient and ii as a tool to track the changes over time in cognitive state of the patients. The MMSE consists of 30 items questionstests, that explore different cognitive domains: spatial and temporal orientation, memorization of words, attention, calculation, recall, language and constructive praxis. The score of the MMSE ranges therefore from 0 to 30. A corrected score of 23 is usually considered suggestive of cognitive decline. The score of the MMSE is corrected for age and education of the patient. 