 Vulnerable groups will not be participating in this research hence no special measures will be taken for their recruitment. Participants will also be informed of any potential safety concern that may arise during the study and will be advised about further treatment options. Wherever possible the Hospitals translation service will be used to offer translation of the consent form to patients who do not have English as their first language. Other individuals, who require specialist communication such as the visually impaired or those who suffer from deafness will wherever possible, be accommodated with the hospitals on-site services. 