 20. History of arrhythmia multifocal premature ventricular contractions PVCs, bigeminy, trigeminy, ventricular tachycardia, or uncontrolled atrial fibrillation which is symptomatic or requires treatment NCI CTCAE Grade 3 or 4 or asymptomatic sustained ventricular tachycardia. Atrial fibrillation, controlled on medication, is not excluded. 