 Two hundreds and ten women with premenstrual syndrome will be randomly divided into 3 equal groups using computer generated random numbers. Group 1 will receive oral dienogest visanne Bayer, Germany 2mg for 14 days starting from the 15th day of menstruation, Group 2 will receive fluoxetine Prozac Lilly, UK 20mg and group 3 will receive an oral placebo foe 14 days starting from the 15th day of menstruation. 