 - Bilirubin greater than or equal to 1.5 mgdL unless due to Gilberts syndrome unconjugated hyperbilirubinemia in which case the bilirubin should be 3.5 mgdL; aspartate transaminase ASTalanine transaminase ALT greater than or equal to 3 x upper limit of normal ULN; serum creatinine greater than or equal to 1.5 mgdL; hepatic alkaline phosphatase greater than or equal to 3.0 x ULN; prothrombin time PT or international normalized ratio INR within normal range unless a patient is receiving anticoagulation therapy; or partial thromboplastin time PTT within normal range 