 Blood and buccal samples are acquired from patients at baseline and prior to courses 2 and 3. Samples are examined by fluorescent in situ hybridization FISH, immunohistochemistry, polymorphism analysis, and protein expression assays to assess molecular markers epidermal growth factor receptor, K-RAS, pMAPK, pAKT, p27 and Ki-67 for biologic effects and predictive response. 