 - Abnormal ovarian reserve, defined as follicle stimulating hormone FSH of 10 IUL on day 2-4 of the cycle and anti-mullerian hormone AMH 1ng ml If only one of the two parameters altered then patients is acceptable. This is based on Mandy Katz abstract at American Society for Reproductive Medicine ASRM 2011 where they showed that these patients have 35 chance of having no euploid embryos - They are excluded only to make the study size smaller, otherwise, if an euploid embryo is found in these patients, they implant as well as patients with normal ovarian reserve. Not all centers do AMH testing - we recommend first to run FSH and only test AMH if FSH is abnormal. 