 At University California, Irvine, Sue and Bill Gross Stem Cell Research Center will be a key component of the Stem Cell Core Facility. This facility provides stem cell technology and resources to the UCI faculty Please see attached letter. By merging technical and scientific expertise in a number of essential disciplines, the Core harbors a diverse tool kit for the exploration of multiple aspects of stem cell biology. The Core also provides a knowledge base for differentiating, genetically modifying and assaying human embryonic stem cells hESCs in support of multiple stem cell projects on campus and in the surrounding area. All services and procedures are performed in accordance with good quality assurance and record keeping practices pursuant to standard operating procedures and good laboratory practices. 