 The grade of each adverse event evaluation mainly allocated in Grade 0 and Grade 1. The incidence of Grade 3 or 4 was only found for the following symptoms: leucopenia, neutropenia, and anemia. One 6 adverse event of leucopenia occurred at visit 1 and visit 2, respectively. One 6 adverse event of neutropenia occurs at visit 1, visit 2, and visit 3, respectively; while 2 13 events occurred at visit 5. One patients suffered adverse event of anemia at visit 5 and visit 6. 