 Recent results showed that reduced intensity conditioning can be safely and effectively used for alloHCT of adult patients with ALL. However, the reduced intensity conditioning RIC can increase the possibilities of hematologic relapse, especially due to the reduced anti-leukemic effect. Another challenge in performing alloHCT for ALL is the donor availability - the limited availability of matched sibling donor MSD and well-matched unrelated donor WMUD forces us to find the feasibility of alternative donors such as partially-matched unrelated donor PMUD or haploidentical familial donor familial mismatched donor, FMD. 