 Epidermolysis Bullosa EB is a rare group of inherited disorders that typically manifest at birth as blistering and lesion formation on the skin and, in some cases, the epithelial lining of other organs, in response to little or no apparent trauma. In consequence, the skin is extremely fragile which can result in shearing of the skin, causing a high risk of infection. All forms of EB are both debilitating and life threatening. In some EB subtypes, high mortality occurs before the age of 1 Junctional Herlitz, and others in adolescence to early adulthood, typically due to infection or failure to thrive. In addition, children surviving into their 20s and 30s are also at risk for development of a virulent form of squamous cell carcinoma, which is in many cases fatal. 