 - Clinically significant abnormal physical examination, vital signs or 12-lead electrocardigram ECG at Screening or at admission to the study center on Day -1, as deemed appropriate by the investigator. This would include: resting pulse 100 or 40 beats per min, blood pressure systolic 140 or 90 millimeters per mercuric level mmHg, and diastolic blood pressure 90 or 50 mmHg pulse and blood pressure measurements should be taken in a supine position, after resting for at least 5 minutes 