 7. Adequate Renal function: Creatinine Cr 1.5 mgdL x ULN, Creatinine clearance CrCl 50 mLmin calculated by the Cockcroft-Gault method as follows: Male creatinine clearance 140 - age x weight in Kg serum Cr x 72 Female CrCl 140 - age x weight in Kg x 0.85 serum Cr x 72 