 This trial is a multi-center clinical and endoscopic outcomes project involving a single large database of patients with Barretts Esophagus BE. The initial goal of this project is to define the incidence and prevalence of cancer and high-grade dysplasia HGD in patients with BE. Thus, our hypothesis is that systematic collection of data on the natural history of BE and risk factors for progression of BE will provide useful information to develop a decision model for risk stratification and risk reduction strategies in BE. 