 After establishing the unique microbiome signature in a large cohort of CAD patients, the investigators would correlate it to TMAO levels to further investigate its part in the pathophysiology of CAD. In the final stage, the investigators would try to find ways to adjust personalized treatment options to change the pro-atherosclerotic gut microbiota. By using data from the current study with the investigators previous 1000 patient cohort with known microbiome and nutritional profile, it would be able to search for a specific target for nutritional intervention, such as probiotics. Then, the investigators would monitor the patients with sequencing the microbiome after the nutritional intervention. 