 - Archival tissue paraffin blocks or unstained slides from paraffin blocks from the primary tumor andor a metastatic site judged reasonably available prior to initiating treatment, or willingness to undergo fresh pre-treatment tumor biopsy. Prior to initiating treatment, the screening team must have documentation that an archival or fresh tumor specimen has been requested from a local or outside facility. However, physical possession of requested tissue or waiting for histological analysis or confirmation that an acquired specimen contains tumor tissue sufficient for analysis is not a requirement prior to initiating treatment. If no archival tissue is available and patient consents to a fresh biopsy, but the patients lesion is deemed inaccessible to safe biopsy, the patient will be allowed to enroll if otherwise eligible. 