 At the same time, lower cutaneous toxicity is expected with this modulated schedule due to the possibly increased cellular repair. Pharmacokinetics data of Cetuximab we found on the population: Vmax 4.38mgh 15.4, Km 74gml, central compartment volume Vl 2.83 l 18.6, peripheral compartment volume 2.43 l 56.4 and intercompartmental clearance 0.103 lh 97.2. Those parameters remain unmodified also during prolonged therapies. Administrated doses have been found to be adequate to cell wall receptors saturation. 