 Clinically, BCC are characterized by small, translucent, or pearly papules, with raised teleangiectatic edges 17 . Most of the BCC occur in sun-exposed skin of the head and neck area 18,19. Sensitivity and positive predictive value for the clinical diagnosing of BCC by dermatologists has been reported to be 95.4 and 85.9, respectively 20. However, dividing between BCC subtypes is not always possible upon clinical assessment. To date, histological analysis of punch biopsy remains the golden standard to confirm the clinical diagnosis of BCCs and dividing between the following subtypes: nodular nBCC, micronodular mnBCC, infiltrating iBCC and superficial sBCC 10. Of those, nBCC and sBCC have a less aggressive growth pattern in comparison to mnBCC and iBCC. Additionally, mixed type BCC mtBCC can be defined as a combination of subtypes and are frequently composed of aggressive subtypes 21. Surgical excision remains the standard of treatment, with Mohs micrographic surgery typically utilized for high-risk lesions 22. Based upon the histological growth pattern, BCC are surgically removed with a margin of either 3mm nBCC and sBCC or 5mm mnBCC, iBCC in accordance with current Dutch guidelines 10. 