 - Use of prescription or nonprescription drugs and dietary supplements within 7 days or 5 half lives whichever is longer prior to the first dose of study medication. Herbal supplements must be discontinued 28 days prior to the first dose of study medication. As an exception, acetaminophenparacetamol may be used at doses of 1 gday. Limited use of non prescription medications that are not believed to affect subject safety or the overall results of the study may be permitted on a case-by-case basis following approval by the sponsor. 