 - Significant history of alcoholism or drugchemical abuse as per investigators judgment, current regular alcohol consumption of more than 1 unit per day for women and more than 2 units per day for men 1 unit of alcohol equals 1 beer 330 mL, 1 glass of wine 120 mL, or 1 glass of spirits 40 mL, or a positive result in the urine drugalcohol screen at the screening visit 