 A prospective, multi-center, open-label trial was conducted at four centers in Germany to evaluate a modified Plicator technique for the treatment of patients with symptomatic GERD. Primary efficacy was based on analysis of the GERD Health Related Qualify of Life HRQL questionnaire at 6-months post-treatment. Additional efficacy outcomes assessed were heartburn and regurgitation symptoms scores, visual analog scale VAS score, GERD medication use, esophageal pHmanometry, and esophagitis. Trial sample size was chosen to provide 87 power in detecting a 50 median reduction in GERD-HRQL score at an alpha level of 0.05. 