 Standard treatment for newly diagnosed glioblastomas after surgery begins with six weeks of combined radiation Monday-Friday and chemotherapy with an oral drug called temozolomide Temodar that patients normally take at home daily including weekends during the six weeks. Patients then have four weeks off treatment. After four weeks off, patients resume taking temozolomide on a monthly basis. During this phase of treatment, patients take a higher dose of temozolomide for only five days out of every twenty eight days they take the drug only during the first five days of every 28 day cycle with the remaining 23 days off drug. Patients continue taking temozolomide on a monthly basis until tumor progression, they complete six to twelve months of treatment or they are unable to tolerate the drug any longer due to side effects. 