 Minocycline: we will use the dosage of minocycline that is currently used for clinical indications and also used in trials employing this drug as an anti-inflammatory agent. Minocycline will be administered in the period of 36 hrs before surgery 100 mg twice a day and 200 mg in the morning of the surgery - total of 5 doses and 12 hrs after surgery single dose of 100 mg. 