 7. Subjects must agree to discontinue intake of alcohol and beverages or food known to interfere with CYP metabolic enzymes such as: grapefruit- and quinine-containing food and beverages e.g., tonic water, bitter lemon, orange juice, prune juice, pomelos, cranberry, pomegranate, star fruit, Seville oranges or marmalade made from them, garlic supplements, St. Johns Wort or licorice from 72 hours before admission to the clinical unit until completion of the study. 