 Blood sampling: a routine part diabetes care, may result in slight pain and bruising, risks minimized by sampling undertaken by staff experienced in venepuncture procedures. Patient burden: participation involves 2 blood samples 3 years apart and 5 follow up contacts over the 3 year period via participant choice of phonee-mailtext. This was not considered unduly burdensome. Immediatedelayed ODS feedback: following considerable discussion around the acceptability of immediate or delayed feedback of results from the ODS, our lay members felt that considering all participants would receive treatment based on current clinical and NICE guidelines the delay in feedback of ODS results would be acceptable. 