 - Laparotomy is performed within 4 weeks after randomization. At laparotomy careful examination of the abdominal cavity is performed to exclude extra-hepatic disease. In case of any doubt of extra-hepatic disease samples are taken for frozen sections. When positive, the operation is terminated. Intra-operative ultrasound should be performed to detect and localize all metastatic lesions. Lesions within 1 cm of each other are considered as satellite lesions and are counted as one lesion. In case intra-operative examination shows more than 4 lesions and complete resection of all lesions is still possible, resection is allowed within the study proposal. Complete resection of all metastatic lesions should always be achieved, if possible with a safety margin of 1cm of normal parenchyma. The type of liver resection anatomical, wedge or combination is at the surgeons discretion. In case complete resection of all lesions seems not possible the operation is terminated. The use of local ablative techniques like radiofrequency or cryosurgery is not allowed within the study. The post-operative course and complications are recorded as well as duration of hospital stay. 