 The index lesion primary ulcerated and all other ulcerated lesions will be assessed for clinical response by measurement of the length and width of area of ulceration. A lesion will be considered to be completely cured if 100 re-epithelialization is observed i.e., this is a measurement of ulceration of 0 x 0 mm. Non-ulcerated lesions will also be measured to monitor the total area of exposure of lesions to study drug and will be evaluated for cure i.e., absence of signs of an active lesion. 