 Prior skeletal related events pathologic fracture, radiation or surgery to bone, or spinal cord compression are allowed if they have been managed and now patient is stable for 4 weeks prior to study entry. Must submit how events managed to BrUOG for documentation to confirm eligibility criterion. For example, if a patient experienced a SSE and had radiation for 2 weeks they must then be stable for 4 weeks after the completion of radiation prior to study entry Subjects must be able to understand and be willing to sign the written informed consent form. 