 This is an international randomized multicenter trial with two parallel arms in a 1:1 ratio. Consecutive patients with solid pancreatic masses and an indication to perform EUS-guided tissue acquisition will be evaluated and, if eligible, will be enrolled into the study.Patients will be randomized in a 1:1 ratio, using random 10 patients block sizes for allocation concealment between groups. An online randomization module will be made available to the participating centers. Randomization will take place after the lesion will have been visualized with EUS and the patient will be found suitable for inclusion. The choice of the needle to be used will be at the discretion of each endosonographer and will be done before randomization so that the choice of the needle does not create bias in the results. Nor the endoscopist, neither the pathologist will be blinded to which needle will be used. 