 Exclusion Criteria: hypogonadotropic hypogonadism that might respond to gonadotropin injections; use of anabolic steroids,illicit drugs, or consumption of more than 4 alcoholic beverages daily; current therapy with retinoic acid eg Accutane or vitamin A- of use of isotretinoin within eight weeks of start of dosing;phenytoin, or medication containing tetracyline; personal history of serious psychiatric disorders, score of greater than 15 on the PHQ9 mood questionnaire; elevated serum serum triglycerides or other abnormal serum chemistry values; history of inflammatory bowel disease or bone disease; not living within catchment area; participation in another clinical trial 