 In a within subjects design, experienced smokers will perform cognitive tasks involving memory encoding and consolidation, selectivedivided and sustained attention, as well as reward and temporal error reward processing two hours following single blind application of a nicotine patch 21 mg24 hr and during a separate session on a different day, following application of a placebo patch. The tasks will be performed during fMRI scanning. Not all of the tasks will be done at the same time, rather, groups of tasks are run in series as task sets: Task set A: Selectivedivided attention task and Intention attention task; Task set B: The SARAT Spatial Attentional Resource Allocation task which is designed to enable dissociation of top-down and stimulus driven processes of visuospatial selective attention as well as the CEFER task which is a measure of central executive function task which isolates the allocation of attentional resources within working memory; Task set C: Monetary Incentive Delay and Temporal Delay Error processing tasks; Task set D: Affective Forecasting and Loss Aversion task. Control subjects will do the tasks during scanning without a patch. Blood will be drawn from all participants for analysis of genetic variants and for smokers, plasma nicotine and cotinine will be measured. 