 4. Cardiac conduction abnormalities denoted by any of the following at the Screening Visit: evidence of second-degree Mobitz type II or third-degree atrioventricular block, evidence of ventricular pre-excitation, complete left bundle branch block, right bundle branch block, intraventricular conduction delay with QRS duration 120 msec, atrial fibrillation, or presence of cardiac pacemaker; PR interval 220 msec or 120 msec; heart rate 45 bpm or 90 bpm; other clinically-significant ECG abnormalities measured as a mean value from triplicate ECGs; 