 3. Fracture Events Fracture incidence in the RPAH patients has been previously reported as 17 in the first 6 months post-transplantation. The fracture rate is now probably lower due to improvements in immunosuppressive therapy. It is not anticipated that this study will have sufficient power to detect a significant reduction in fractures however fracture events will be recorded, including reduction in height of vertebral bodies at baseline and 12 months post-transplantation. 