 - Patients must have steroid refractory cGVHD, defined as having persistent signs and symptoms of chronic GVHD section 13.1 despite the use of prednisone at 0.25 mgkgday or 0.5 mgkg every other day for at least 4 weeks in the preceding 12 months or equivalent dosing of alternate corticosteroids without complete resolution of signs and symptoms. 