 - Known Human Immunodeficiency Virus HIV infection. History or evidence of cardiovascular risk including a QT interval corrected for heart rate using the Bazetts formula QTcB interval 480 msec, history or evidence of current clinically significant uncontrolled arrhythmias, history of acute coronary syndromes including myocardial infarction and unstable angina, coronary angioplasty, or stenting within 6 months prior to randomization, history or evidence of current or Class II congestive heart failure as defined by New York Heart Association, treatment refractory hypertension defined as a blood pressure of systolic 140 mmHg andor diastolic 90 mmHg which cannot be controlled by anti-hypertensive therapy, subjects with intra-cardiac defibrillators or permanent pacemakers. 