 adequately controlled with appropriate therapy or would compromise the patients ability to tolerate this therapy; 2. Treatment with any systemic anticancer therapy 3 weeks prior to cycle 1 day 1 3. Uncontrolled active infection Hepatitis B and C infection are NOT exclusion criteria andor known HIV infection; 4. Renal failure requiring haemodialysis or peritoneal dialysis; 5. Patients who are pregnant or breast-feeding; 6. Patients with significantly diseased or obstructed gastrointestinal tract, malabsorption, uncontrolled vomiting or diarrhea resulting in inability to swallow oral medications; 7. Presence of symptomatic CNS metastasis 8. Unresolved toxicity from previous anti-cancer therapy or incomplete recovery from surgery, in particular oxaliplatin-induced peripheral neuropathy grade 1. 