 - Clinical T2-T4c at diagnosis or screening, any N, M0 invasive ER Allred Score at least 3 or 1 ER positivity and HER2 negative 0 or 1 by IHC or FISH negative or equivocal breast cancer, by AJCC 7th edition clinical staging, with the goal being surgery to completely excise the tumor in the breast and the lymph node. Note: Patients with invasive breast cancer that is ER pos, HER2 neg or equivocal or DCIS in the contralateral breast are eligible; multi-focal diseases are not excluded. The dominant lesion will be followed per protocol 