 Moxifloxacin is 50 bound to plasma proteins. It is widely distributed, with some tissue concentrations in excess of plasma levels. Moxifloxacin is metabolized by glucuronide and sulfate conjugation. The sulfate conjugate M1 accounts for 38 oral dose and is excreted in feces; 14 of an oral dose is converted to the glucuronide conjugate M2 and is excreted in urine. Peak plasma levels of M1 are 10 and M2 are 40 parent drug levels. Much 45 of an oral dose is excreted as the parent drug and 51 as known metabolites. Based on population PK modeling, moxifloxacin AUC0-24 in participants who have TB can be predicted with acceptable accuracy using limited sampling strategy. 