 The secondary objectives of this study are to i determine the incidence of transplant-related mortality TRM at 180 days; ii describe the pattern of biochemical improvement as measured by an increase in protein expression collagen, laminin, integrin, keratin or plakin and related structural and physical changes; iii describe health quality of life at day 365 and 730 as compared to pretreatment results; iv describe the pattern and durability of HSC and third party MSC engraftment in the skin; v determine the probability of survival at 1 year. 