 The purpose of this study is to evaluate the safety profile and efficacy of whole brain radiotherapy WBRT concomitantly with temozolomide TMZ in patients with brain metastases BM.Patients with BM were randomly assigned to 30 Gy of WBRT with or without concomitant TMZ 75 mgm2d plus two cycles of TMZ 200 mgm2d for 5 days. 