 13. Patient has adequate bone marrow and organ function as defined by the following laboratory values at screening: a. Absolute neutrophil count 1.5 × 109L b. Platelets 100 × 109L c. Hemoglobin 9.0 gdL d. Potassium, total calcium corrected for serum albumin, magnesium, sodium and phosphorus within normal limits for the institution or corrected to within normal limits with supplements before first dose of study medication e. INR 1.5 f. Serum creatinine 1.5 mgdL or creatinine clearance 50 mLmin g. In the absence of liver metastases, alanine aminotransferase ALT and aspartate aminotransferase AST 2.5 x ULN. If the patient has liver metastases, ALT and AST 5 x ULN h. Total bilirubin ULN; or total bilirubin 3.0 x ULN or direct bilirubin 1.5 x ULN in patients with well-documented Gilberts Syndrome. 