 The purpose of this study is to compare the efficacy and safety of duloxetine 60 mg once daily to placebo on depression in elderly patients greater than or equal to 65 years of age. Patients who do not respond in the first 13 weeks will be eligible for rescue using pre-defined criteria. Patients randomized to duloxetine 60 mgday meeting the rescue criteria will be increased to 120 mgday. Patients randomized to the placebo arm meeting the rescue criteria will be assigned to duloxetine 60 mgday. 