 6. Have adequate renal function defined as serum creatinine 1.5 the upper limits of normal or creatinine clearance 60 mLmin measured or calculated. In the absence of hematuria, patients must have either a negative urinalysis for protein i.e. no more than trace by dipstick or a 24 hour urine collection showing less than 1,000 mg of protein24 hour. In the presence of hematuria, patients may have up to 2,000 mg of protein24 hour. 