 The genotyping of gene CYP3A5 will be carried out in the 4-7days before renal transplantation. After transplantation, the patients will be treated by MMF, corticosteroids and tacrolimus at a dosage adapted to their genotype0.15mgkgd for CYP3A511 type and CYP3A513 type,0.08mgkgd for CYP3A533 type. 