 Power Calculation Based on the existing literature, we expect that the proportion of patients whose end-of-life preferences were known will be 15 and that an increase to 65 would represent a clinically meaningful effect. To achieve 90 power to detect a difference in the primary outcome between groups with a certainty of 95 , we estimated that 22 deaths would be required in each group, i.e. 44 deaths in total. It is therefore planned to continue the inclusion period until at least 22 deaths are observed in each group among patients enrolled. In a similar study, the population included patients had an average lifespan of 3.5 months the time of inclusion until death and 86 of included patients died during the study period which was 20 months.16 In order to observe 44 deaths, an estimated inclusion of 90 patients is necessary. The estimated inclusion period will be approximately 18 months. 