 Berberine BBR, a compound isolated from a Chinese herb was identified by Weijia 7 as a new cholesterol-lowering drug with a mechanism different from that of statin drugs. BBR elevates LDL receptorLDLR expression through a post-transcriptional mechanism that stabilizes the LDLR-mRNA. Considering the close relationship between NAFLD and lipid metabolism, we assume that BBR may be effective for NAFLD by improving lipid metabolism. 