 - PHASE II: Patients may have had treatment for no more than 2 prior relapses; relapse is defined as progression following initial therapy i.e. radiation- chemo if that was used as initial therapy; the intent therefore is that patients had no more than 3 prior therapies initial and treatment for 2 relapses; if the patient had a surgical resection for relapsed disease and no anti-cancer therapy was instituted for up to 12 weeks, and the patient undergoes another surgical resection, this is considered as 1 relapse; for patients who had prior therapy for a low-grade glioma, the surgical diagnosis of a high-grade glioma will be considered the first relapse 