 The colonoscopy protocol will be the same in both participating centres. All patients will undergo a bowel preparation consisting in the intake of four litres of hypertonic polyethylene glycol solution. The procedures will be performed under conscious sedation using propofol. The caecum will be reached in white light endoscopy in all cases. Cecal intubation will be confirmed by identification of the ileocecal valve and appendiceal orifice. Upon extubation, 20 mg of butyl scopolamine will be given intravenously, barring any contraindication, to reduce colonic motility and facilitate the examination of the colon. When performing the FICE procedure, the imaging mode will be switched to CVC at the caecum and will then be used throughout withdrawal. The endoscopist will classify the degree of inflammation in each segment of the colon on a scale and give the Mayo Clinic score proctosigmoiditis - left-sided colitis - Pan Colitis. The quality of the bowel preparation will be noted. During the extubation phase, washing of the colon and aspiration of waste will be accomplished in an optimal way to maximise the detection capabilities of each procedure. 