 - Use of prescription or non-prescription drugs, including antacids, vitamins, herbal and dietary supplements including St Johns Wort and iron supplements within 7 days or 14 days if the drug is a potential enzyme inducer or 5 half-lives whichever is longer prior to the first dose of study medication, unless in the opinion of the Investigator and sponsor the medication will not interfere with the study procedures or compromise subject safety 