 8. Women of child-bearing potential MUST have a negative serum or urine HCG test unless prior tubal ligation 1 year before screening, total hysterectomy or menopause defined as 12 consecutive months of amenorrhea. Patients should not become pregnant or breastfeed while on this study. Sexually active patients must agree to use dual contraception for the duration of study participation and for 120 days after the last dose of talazoparib. 