 Multiple imputation will be used to impute missing cost and effect data. Intention-to-treat analyses ITT increase the risk of type I errors in non-inferiority NI trials and non-intention-to treat analyses are preferred over ITT analyses in NI designs. Therefore, the primary statistical analyses will be per protocol analyses meaning that only those patients that have completed the treatment will be included in the analyses. ITT analyses will be used in sensitivity analyses to increase confidence in the results obtained by including all participants in the analyses independent of whether they have completed the treatment or not. Blended depression treatment is considered no less effective than care-as-usual when the two-sided 95 confidence interval the range of plausible differences between the two treatments lies entirely above the standard mean difference of 0.20 which is the non-inferiority margin and the smallest clinically acceptable difference. 