 At the beginning of the study, blood will be taken for complete blood count including platelets count and mean platelets volume, serum electrolytes, albumin, blood lipids, KtV, troponin and two 5 ml aliquots from each blood collection will be separated and stored at -70co until analyzed for oxidative stress, homocysteine and highly sensitive CRP will be performed. Five mL of blood will be sent for platelets function assessment described below. 