 Will be included in the study 100 subjects with suboptimal LDL cholesterol levels LDL 100-160 mg dL and hsCRP levels 2 mg L, divided into two groups of equal numbers, matched by by sex and age, randomized to receive a nutraceutical combination containing red yeast 200 mg, berberine 500 mg and policosanol 10 mg NC in combination with a low-cholesterol diet 200 mg day or a low-cholesterol diet only Standard of Care - SOC. 