 - Remission induction therapy SR patients: Patients receive oral prednisone or prednisolone 2-3 times daily OR methylprednisolone IV every 8 hours on days 4-32; vincristine IV on days 4, 11, 18, and 25; doxorubicin hydrochloride DOX IV over 15 minutes on days 4 and 5; methotrexate MTX IV on day 6; pegasparaginase IV over 1 hour on day 7; triple intrathecal therapy TIT comprising methotrexate, cytarabine, and hydrocortisone on day 18; and IT MTX on day 32. 