 6. Serum bilirubin 1.5 mgdl and Cr Clearance 60 mLmin, platelet count 75,000mm3 and absolute neutrophil count ANC 1,000mm3, aspartate aminotransferase AST serum glutamic oxaloacetic transaminase SGOT and alanine aminotransferase ALT serum glutamic pyruvic transaminase SGPT 3 x upper limit of normal or 5 x upper limit of normal if hepatic metastases are present. 