 HYPOTHESIS: 1 Tenecteplase 0.4 mgkg may be given safely to patients with acute ischaemic stroke 412 hours after stroke onset. 2 Tenecteplase 0,4 mgkg single bolushas superior efficacy and safety compared with alteplase 0.9 mgkg 10 bolus 90 infusion60 minutes when given within 4 12 hours after stroke onset. 