 For the development of the new biomarkers using the technique of Mass-spectometry 7,5 ml EDTA blood, saliva tube and a dry blood spot filter card are taken. To prove the correct diagnosis in those patients where up to the enrollment in the study no genetic testing has been done, sequencing will be done. The analyses are done in the Centogene AG, Schillingallee 68, 18055 Rostock Germany 