 The primary objective of the study is to evaluate the effect of fetal bovine serum FBS-freehuman serum albumin HSA-free formulation of Interferon IFN beta-1a RNF 44 microgram three times weekly and once weekly versus placebo on the time to conversion to McDonald multiple sclerosis MS criteria 2005 in subjects with a first clinical demyelinating event at high risk of converting to MS. 