 Hydration A suggested rate of 125 cchr NS should be given starting 6 hours before cyclophosphamide and continue until 24 hours after the last cyclophosphamide dose.The rate of hydration will be aggressively adjusted in order to avoid fluid overload. BID weights will be obtained. Amount of fluid can be modified based on patients fluid status. Minimum target urine output is 2 litersm2day 