 RATIONALE: Over-expression of CDK4 or loss of the CDK4 inhibitor p16 are common in sarcomas and result in a selective growth advantage by bypassing normal cell cycle checkpoints. Intact pRb is required for CDK46 inhibition to be effective, therefore all eligible subjects must have documented pRb expression by IHC on archival tissue. Synergy between CDK4 inhibition and chemotherapy has been documented in preclinical models when given sequentially, suggestion a role for cell cycle synchronization. 