 - increased risk of hemorrhage, due to: pericarditis or bacterial endocarditis, severe uncontrolled hypertension, active ulcerative and angiodysplastic gastrointestinal disease, hemorrhagic stroke, shortly after brain, spinal or ophthalmological surgery, concomitant treatment with platelet inhibitors, recent surgical procedures especially with hemorrhagic complications or those in which hemorrhagic complications would be very severe - cardio-vascular, ophthalmological or neurological, planned surgical procedure within the next week, history of heparin-induced thrombocytopenia, with any other disease which, in the opinion of the investigator, makes unacceptable hisher inclusion in the study known hypersensitivity to heparin, benzyl alcohol, or pork products that should not be treated with innohep, severe psychiatric disorders, age 18 years, malignant disorders and a life expectancy 6 months, patients that were involved in another research study studies in the last month. 