 Recently, the investigators retrospectively assessed the value of a progressive cutoff adjusted to age in a wide sample of 1712 patients with suspected PE. This new cutoff was defined for D-Dimer test positivity in each patient by multiplying patients age by 10. All patients with a D-Dimer level below 500 microgL, and all patients above 50 years whose D-Dimer levels were inferior to their age multiplied by 10 were considered as having a negative D-Dimer test. Using the conventional cutoff, the VIDAS D-Dimer test was negative below 500 microgL in 5121712 patients 29.9 and none had PE during initial workup or the three-month follow-up period. 