 To increase the diagnostic yield, patients who are referred for lung biopsy, will undergo the technique of preoperative labeling: small indeterminate lung nodules are frequently invisible and impalpable. There is an encouraging literature which indicates that preoperative labeling of lung lesions with a small 0.30.5ml volume of methylene blue which acts a guidance track for the surgeon, may significantly improve the diagnostic yield from surgical open or videoassisted thoracoscopic biopsy. 