 Echocardiograms with strain will be performed to determine cardiac structure and mechanical function during the course of treatment. All echocardiograms will include the addition of a new signal sound wave processing method, called strain echocardiography. This technology allows precise analysis of the individual regions of the heart to determine cardiac function. Echocardiograms with strain will be done on four visits using GE strain-capable technology. Echocardiograms will be performed in a manner compatible with strain calculation by either GE or Tomtec software depending on which software the echocardiography lab has experience using. The baseline echocardiogram will be within a window of 28 days prior to starting doxorubicin-based chemotherapy regimen. The second will be obtained between 1-4 weeks after receiving a cumulative dose of at least 240mgm2 and before another dose is given. The third echocardiogram is obtained 6 months -4 weeks after the start of C1D1. The final echocardiogram will be obtained 12 months -4 weeks after the start of C1D1. 