 This study evaluates the safety and clinical benefits of a therapeutics approach of conditioning regimen Cyclophosphamide Cy Thymoglobulin r ATG Granulocyte Colony-Stimulating Factor G-CSF followed by autologous Hematopoietic Stem Cell Transplantaion HSCT rescue in therapy refractory Crohns disease. It will be counted adverse events, clinical and endoscopic condition at various short and long-term time points. 