 - Patients not previously treated by surgery, radiotherapy, hormone therapy or chemotherapy. Haematology: o Neutrophil count 1.5x109Lo Platelet count 100x109Lo Leucocyte count 3,000mmo Hb 9gdl Hepatic Function:o Total bilirubin 1.5 time the upper normal limit UNLo ASAT 2.5xUNL in absence of liver metastases, or 5xUNL in presence of liver metastases ALAT 2.5xUNL in absence of liver metastases, or 5xUNL in presence of liver metastases Alkaline phosphatase 2.5 time the upper normal limit UNL Renal Function Creatinine clearance 50 mLmin and serum creatinine 1.5xUNL Metabolic Function o Magnesium lower limit of normal. o Calcium lower limit of normal. 