 a Inadequate hematologic function defined by: i White blood count WBC 3.0 x 109l ii Platelet count 100x109l iii Hemoglobin level 100 gl b Inadequate hepatic function as defined by either: i Total bilirubin level 1.5 times the upper limit of normal ULN ii Aspartate amino transferase AST or alanine amino transferase ALT 3 times the ULN if related to liver metastases 5 times the ULN c Inadequate renal function defined as serum creatinine 1.5 times the ULN 