 13. Clinically significant cardiovascular disease including: a Myocardial infarction within 6 months of Screening visit; b Uncontrolled angina within 3 months of Screening visit; c Current or past history of congestive heart failure NYHA class III or IV or history of anthracycline or anthracenedione mitoxantrone treatment, unless a screening echocardiogram or multi-gated acquisition scan MUGA performed within three months results in a left ventricular ejection fraction LVEF that is 50; d History of clinically significant ventricular arrhythmias e.g., ventricular tachycardia, ventricular fibrillation, torsade de pointes, grade 2 cardiac dysrhythmias, atrial fibrillation of any grade, or QTcF interval 470 msec on the screening Electrocardiogram ECG; e History of Mobitz II second degree or third degree heart block without a permanent pacemaker in place; 