 As a result of new information, it has been decided that subjects in Arm A will continue receiving their dosing every 3 weeks. All other subjects will be dosed weekly. The dose you receive may be too low to have an effect or so high it causes bad side effects. In the second part of this study the highest dose of NC201 will be given to learn if ONC201 can help to control the disease. Please note that this is the first time ONC201 will be given to human subjects. 