 Diabetes mellitus is a common disease with much impact on humans health and is related to osteoporosis. But the mechanism remains unclear. The foreign researches revealed thiazolidinedione TZD would increase the risk of osteoporosis and bone fracture, especially elderly women. However, it is still controversial in terms of the youth and men. In Taiwan, there is few related study to analyze the relationship between TZD and osteoporosis. 