 - Patients should have adequate bone marrow function defined as an absolute peripheral granulocyte count AGC of 2000 cellsmm3, platelet count of 100,000 cellsmm3 pre treatment without intervention. Bilirubin 1.5 mgdl, AST or ALT2 x upper normal, serum creatinine1.5mgdl, creatinine clearance 50mlmin. 