 Nephropathic cystinosis is the most frequent and most severe form of cystinosis. The symptoms of nephropathic cystinosis usually become apparent within the second half of the first year of life. Specific symptoms can be mild or severe based upon each individual case and the age when treatment is started.Growth failure and renal Fanconi disease are usually the first noticeable complications of the disorder. Although infants appear normal at birth, by the age of one they often fall into the third percentile for height and weight. In addition, affected infants may have episodes of vomiting, poor appetite, and feeding difficulties that contribute along with kidney dysfunction to nutritional deficiency and the failure to gain weight and grow at the expected rate failure to thrive. Ultimately, growth in untreated children with cystinosis occurs at 60 percent the expected rate. 