 13. Significant cardiac disease that would preclude the use of anthracyclines: No myocardial infarction in the last 6 months; history of congestive heart failure, serious cardiac arrhythmia requiring medication, active coronary artery diseaseangina pectoris requiring therapy, uncontrolled hypertension defined as BP 15090 despite medication; any other unstable cardiac condition as perceived by treating physician or study PI. 