 Finally, there is little data from clinical studies that demonstrates that attempting to correct abnormal coagulation tests with FP reduces bleeding. Based on clinical experience, in patients with a high INR and active bleeding, FP may be beneficial in controlling bleeding. However, the prophylactic use of FP has never been shown to reduce bleeding. The only prospective clinical trials showed no reduction in bleeding following FP transfusion in neonates, patients with pancreatitis or after cardiac surgery. A retrospective study of FP use in critical care patients showed no differences in bleeding after the administration of FP. 