 Inclusion Criteria: - Diagnosis of CKD and not expected to initiate dialysis for the duration of the study - Estimated glomerular filtration rate eGFR: greater than or equal to 15 mLmin and less than or equal to 60 mLmin measured by the following modified MDRD Modification of Diet in Renal Disease equation: eGFR 186 x serum creatinine-1.154 x Age-0.203 x 0.742 if subject is female x 1.212 if subject is black - Clinically stable, in the judgment of the investigator - Mean Hb greater than or equal to 11.0 gdL to less than or equal to 13.0 gdL mean of 2 values drawn at least 3 days apart during the screening period - Transferrin saturation Tsat greater than or equal to 15.0 - Serum vitamin B12 and folate levels above the lower limit of the normal range - Receiving stable Q2W subcutaneous SC doses of Aranesp darbepoetin alfa. A stable dose is defined as less than or equal to a 25 change in dose over the 6-week period immediately prior to enrollment and with no missed doses in this period Exclusion Criteria: - Prior recipient or scheduled to receive a kidney transplant - Diastolic blood pressure BP greater than 110 mm Hg or systolic BP greater than 180 mm Hg during screening - Acute myocardial ischemia - Hospitalization for congestive heart failure or myocardial infarction within 12 weeks before enrollment - Parathyroid hormone level greater than 1500 pgmL - Major surgery within 12 weeks before enrollment excluding vascular access surgery - Currently receiving antibiotic therapy for systemic infection - Known positive HIV antibody or positive hepatitis B surface antigen - Clinical evidence of current malignancy andor receiving systemic chemotherapyradiotherapy with the exception of basal cell or squamous cell carcinoma of the skin and cervical intraepithelial neoplasia - Red blood cell RBC transfusions within 8 weeks before enrollment - Androgen therapy within 8 weeks before enrollment - Systemic hematologic disease e.g., sickle cell anemia, myelodysplastic syndromes, hematologic malignancy, myeloma, hemolytic anemia - Any disorder that may impact in the judgment of the investigator the ability to give informed consent for participation in this study - Pregnant or breast-feeding women - All subjects must practice adequate contraception in the judgment of the investigator throughout this trial - Treatment with an investigational agent or device within 30 days before enrollment or scheduled to receive an investigational agent other than those specified by this protocol during the course of this study 