 - Use of any enzyme-modifying drugs, including strong inhibitors of cytochrome P450 CYP enzymes such as cimetidine, fluoxetine, quinidine, erythromycin, ciprofloxacin, fluconazole, ketoconazole, diltiazem and HIV antivirals and strong inducers of CYP enzymes such as barbiturates, carbamazepine, glucocorticoids,phenytoin and rifampin, in the previous 28 days before Day 1 of this study. 