 2. More than one prior chemotherapy lines for metastatic breast cancer. Previous neoadjuvant chemotherapy or for radically treated local or regional relapse is allowed in addition to one prior chemotherapy line for metastatic breast cancer Note: A chemotherapy line in advanced disease is an anticancer regimen that contains at least one chemotherapy agent and is given for 21 days or longer. If a cytotoxic chemotherapy regimen was discontinued for a reason other than disease progression and the decision for its discontinuation was taken within 21 days after starting it, then this regimen does not count as a prior line of chemotherapy. Chemotherapy regimens composed of more than one drug are considered as one line of therapy. 