 Coenzyme Q10 CoQ10 is a safe and feasible medicinal intervention with a strong scientific rationale for use in septic shock. CoQ10 is a key component of the mitochondria, serving as an electron transport medium between complex III and complex III. A lesion at this point in the electron transport chain results in an inadequate production of ATP adenosine triphosphate for the cell. In septic shock, CoQ10 levels are profoundly decreased and therefore production of energy may be compromised. CoQ10 has two essential roles in critically ill patients with sepsis: 1 production of ATP and 2 reduction of free oxygen radicals. CoQ10s key role in the electron transport chain may prevent the well-described mitochondrial dysfunction that occurs in patients with septic shock. Thus, these two essential roles form the pathophysiological basis for this proposed study. 