 Defined procedures are employed for generation of autologous dendritic cells for clinical application in a classified laboratory. Unmobilized leukapheresis will be used for isolation of large-scale mononuclear cells, and dendritic cells will be generated from monocytes by cytokine stimulation and loaded with p53 peptides. Frozen preparations of dendritic cells will be prepared using automated cryopreservation.Each patient will receive a minimum of 5x106 dendritic cells per treatment supplemented with interleukin-2 6 MIUm2 sc per vaccine and 1.6 mg Thymosin 1 alpha sc x 2week. 