 - Participants with history of clinically significant medical illness prior to Screening including but not limited to chronic atrial fibrillation, hemodynamically significant valvular heart disease, heart failure New York Heart Association Class II within 6 months prior to the Screening visit, cardiac revascularization within 6 months including percutaneous transluminal coronary angioplasty or coronary artery bypass graft surgery, ischemic stroke within 6 months, previous intracranial hemorrhage at any time, anemia with a hemoglobin concentration 9 gram per deciliter gdL, or any other illness that the investigator considers should exclude the participant or that could interfere with the interpretation of the study results 