 - Organ and marrow function as follows: absolute neutrophil count ANC 1500mm3, platelets 100,000dL, hemoglobin 9 gdL, bilirubin 1.5 mgdL, serum creatinine 1.5 mgdL or creatinine clearance 60 mLmin, alanine aminotransferase ALT and aspartate aminotransferase AST 2.5 times the upper limit of normal if no liver involvement or 5 times the upper limit of normal with liver involvement; 