 Subjects must meet all of the following inclusion criteria to participate in this study: 1. Male or nonpregnant female as indicated by a negative urine pregnancy test immediately prior to vaccine administration between the ages of 18 and 64 years, inclusive. 2. Women of childbearing potential who are at risk of becoming pregnant must agree to practice adequate contraception ie, barrier method, abstinence, and licensed hormonal methods for the entire study period. 3. Is in good health, as determined by vital signs heart rate, blood pressure, oral temperature, medical history and a targeted physical examination based on medical history. 4. In Stage I subjects, should have normal laboratory values of Hgb, WBC, Plt, ALT, and creatinine prior to the first immunization. 5. Able to understand and comply with planned study procedures. 6. Provides informed consent prior to any study procedures and is available for all study visits. 