 Peripheral blood biological tests will be the following Laboratory designation : i viral load measurement, PBMC isolation, DNA extraction, proviral DNA measurement, cell and DNA storage Virology, Timone CHU, Marseille; ii assays of CD4, CD8, glycemia, insulinemia, HOMA, total-, LDL- and HDL-cholesterol, triglycerides Biochemistry labs from the 3 CHU ; iii antiretroviral drug assay mass spectrometry Pharmacokinetics, Timone CHU, Marseille; iv detection western blotting, immunocytochemistry combined to image analysis of nuclear abnormalities of PBMC nuclear, cytosolic and mitochondrial targets of antiretroviral drugs : A and B lamins, NF-B I-B and proteasome activity assay, CD36 glycosylation, mitochondrial Hsp70, ROS mitochondrial production, mitochondrial inner membrane potential, cytochrome C oxidase subunits 2 and 4 Cell Biology, Timone CHU, Marseille ; v genotyping the antiretroviral targets : lamin A ZMPSTE24 and B Rce1 processing proteases, Golgi SREBP-releasing proteases MBTPS1 and S2, mitochondrial deoxynucleoside transporters SLC25A4 to A6, mitochondrial proteases MPPA, paraplegin involved in processing of nuclear encoded proteins during their mitochondrial import ; quantitative PCR measurement of telomere length Molecular Genetics, Timone CHU, Marseille. Marseilles CIC-UPCET collaborated to the protocol design, will recruit control subjects and will be responsible for statistical treatment of data. 