 total bilirubin 1.5 x institutional upper limit of normal ULN ASTSGOTALTSGPT 2.5 x ULN serum creatinine 2.0 mgdL OR creatinine clearance 60 mLmin1.73 m2 for patients with creatinine levels above institutional normal. The creatinine clearance in male patients may be calculated using the Cockcroft-Gault formula: CrCl mLmin 140 - age x weight kg 72 x Cr mgdL. Note: in female patients, this calculation must be multiplied by a factor of 0.85. 