 A 35-month cross-sectional observational study was conducted at an outpatient university hospital in Amman, Jordan. We obtained a comprehensive medical and laboratory evaluation for 134 short-statured children 64 boys and 70 girls, aged 4-16 years. Complete and partial growth hormone deficincy GHD were defined as peak forwth hormone GH response of 5 and 7 ngml IRMA DiaSorin, respectively in both clonidine stimulation and insulin tolerance tests. Serum IGF-I, IGFBP-3 and IGF-IIGFBP-3 ratio were determined for all participants. 