 In this study, patients with active pouchitis after ileal pouch-anal anastomosis IPAA for Ulcerative Colitis with primary symptoms such as increased stool frequency and abdominal pain, and refractory to antibiotics do not respond to antibiotic therapy for a minimum of 14 days will be enrolled. Patients must have active pouchitis confirmed by endoscopy and biopsy within 4 weeks of study entry. The diagnosis of active pouchitis will be defined by a PDAI score 7 points, with a combined assessment of symptoms, endoscopy and histology. 