 REFLEXION is a double blind extension of the study 27025 NCT00404352 REFLEX. The purpose of the study is to obtain long-term follow-up data in subjects with clinically definite multiple sclerosis MS and subjects with a first demyelinating event at high risk of converting to MS, treated with fetal bovine serum FBS-freehuman serum albumin HSA-free formulation of interferon IFN-beta-1a RNF. 