 Three arms will be studied in this research, 520 naive-treatment patients would be randomized to two groups, taking the generic drugs 3TCD4TNVP or AZT3TCNVP, 6 months later half of the 3TCD4TNVP group will switch to AZT3TCNVP, in order to observe the efficiency and safety of the first line drugs. Arm 2 will recruit 100 patients who are taking ARV for about three years already. Arm 3 will recruit 150 patients who have a Viral load of more than 1000 copiesml, i.e., drug resistance. The second line drug 3TCTDFLPVRTV will given to them and the safety and efficiency will be observed. All patients should be explored in terms of the clinical features, drugs side-effects, and immunological and viral response. The drug concentration and the metabolism changes would be explored also. Also the immune reconstitution will be studied for all patients. This study will be the first large-scale, multicentered, randomised, prospective ARV therapy study in China for HIVAIDs patients. The result would provide proves for further practical antiviral therapy for China or other resource limited countries. 