 - Laboratory values: hemoglobin 9.0gdl, neutrophils 1.5×109L, platelets 100×109L , ALT 2.5 x upper limit of normal ULN, AST 2.5 x ULN, serum bilirubin 1.5 x ULN, serum creatine 1.5 x ULN, creatinine clearance rate 50mlmin, PT, APTT, TT, Fbg normal 