 An open, randomized, parallel-group, comparative, multicentre study. Patients on corticosteroids plus conventional therapy will be randomized to receive anakinra Kineret, or one of the following: methotrexate, azathioprine, leflunomide, cyclosporin A or sulphasalazine. Patients enter the study if considered refractory to corticosteroids prednisolone equivalent 10 mgday at the time of randomization. 