 Approximately 60 participants will be randomized at Week 0 Visit 3 in a 1:1 ratio to receive either 1 a meal replacement program with Glucerna SR on top of the EDP or 2 an caloric-matched EDP only. The participants will receive an educational program of diet, exercise, and behavioral strategies at randomization. Each randomized subject in the meal replacement group will receive Glucerna SR to replace one meal breakfast and one pre-sleep snack for 24 weeks. The subjects in the group with EDP only will receive a meal plan like they have in the lead-in period. All study subjects will be placed on a diet plan with 500 800 kcalday less than their estimated daily maintenance energy requirement and receive an individualized exercise prescription to facilitate an optimal diabetes management. The participants will visit the clinics at 4-week intervals for 24 weeks after randomization to evaluate the efficacy and the safety parameters. The participants will receive two different meal tests at both the baseline and the end of the study. The macronutrient composition in the meal test protocol 1 is a 480 Kcal Glucerna SR breakfast with 50 CHO, 20 protein, and 30 fat. The test meal protocol 2 is a 480 Kcal sandwich breakfast with 63 CHO, 20 protein, and 17 fat. The primary efficacy variable will be the change from baseline in incremental area under curve AUC of glucose response after a Glucerna-SR test meal between the two groups. 