 - On a generally stable antihyperglycemic agent regimen i.e., with no change in medication, or only 1 dose step change in dose for at least 2 months prior to the Screening Visit, including volunteers who are:a Not currently on antihyperglycemic therapy and have an HbA1c 7.0 and 10.0, or b On a single oral antihyperglycemic agent metformin, a sulfonylurea, a meglitinide e.g., repaglininide or nateglinide, a DPP-4 inhibitor sitagliptin or vildagliptin, or an alpha-glucosidase inhibitor e.g., acarbose and have an HbA1c 6.5 and 9.5, or c On low-dose dual oral agent therapy i.e., 50 maximum labeled doses of both agents and have an HbA1c 6.5 and 9.5 