 Project development and user involvement: The study team will have access to the user representative group of the NIHR Exeter Clinical Research Facility ECRF. In keeping with the NHS Patient Carer and Public Involvement PCPI strategy the ECRF invites user representatives to contribute to the development of various projects within its portfolio. These individuals have agreed to maintain contact and regular meetings have been established at which researchers discuss the development of current projects within the ECRF. 