 - Previous immunomodulatory or immunosuppressant treatment during the 30 days prior to day 0 of the study with the following agents e.g., IFN-β, GA, mitoxantrone, cyclophosphamide, cladribine, fludarabine, cyclosporine, total body, azathioprine, methotrexate, IVIG, cellcept, natalizumab, etc. 