 Blood samples are collected at baseline and periodically during study for correlative laboratory studies. Peripheral blood mononuclear cells are analyzed for STAT proteins STAT1, STAT2, STAT3, STAT4, STAT5 and CD4, CD25, and FoxP3 regulatory T cells by flow cytometric assays. Samples are also analyzed for the presence of VEGF, VEGFR, IFN-γ, and IL-5 by ELISA assays; baseline expression of Jak-STAT signaling intermediates Jak1, Tyk2, IFNAR, and IRF9 by immunoblot analysis; and interferon-stimulated gene expression by real time PCR and RT-PCR analysis. 