 Intervention: 10-day sequential regimen pantoprazole 40 mg, amoxicillin 1 g plus placebo for the first 5 days, followed by pantoprazole 40 mg, clarithromycin 500 mg and tinidazole 500 mg for the remaining 5 days in 150 patients or standard 10-day therapy pantoprazole 40 mg, clarithromycin 500 mg, and amoxicillin 1 g in 150 patients. All drugs were given twice daily. 