 - Required Initial Laboratory Values: Absolute neutrophil count 1.2 x 109L; Platelets 100 x 109L; Bilirubin 1.5 times the upper limit of normal x ULN for the institution; Aspartate transaminase AST and alanine transaminaseALT 3.0 x ULN;Serum creatinine 2.0 or calculated creatinine clearance CrCl 30 mLmin 