 3. Preliminary StudiesProgress Report To our knowledge there is not previous data determining if Edi can predict extubation success. However, there are a few limited studies on low and high-frequency diaphragm fatigue in adults and animals. Dr. Laghi and colleagues carefully examined 11 who failed extubation and eight adults whom successfully weaned from mechanical ventilation. They concluded that weaning itself did not cause low-frequency fatigue 13. While Edi was examined in six health adults at high frequency fatigue levels. Edi was found to successfully assess neural drive and that diaphragm fatigue did not affect respiratory drive. 