 22. Subject has used prescription or nonprescription drugs, vitamins, or dietary or herbal supplements within 14 days prior to dosing or anticipates the need for any medication during their participation in this study exception: female subjects who are taking oral, patch, or intrauterine device IUD hormonal contraceptives, or progestin implant or injection. Enzyme modulating herbal supplements eg, MetabolifeTM must be discontinued 30 days prior to the first dose of study drug. 