 Water will be restricted from 1 hour prior to dosing until 1 hour post-dose. Subjects will receive SRT2104 within 30 minutes following the start of consumption of a standardized non-high-fat meal approximately 650 kcal with approximately 30 of calories derived from fat. A light lunch will be provided 4 hours post-dose, an evening meal approximately 8 hours post dose and a snack approximately 12 hours post dose. 