 hemoglobin 9 gdL,absolute neutrophil count ANC 1.5109L, platelets 100 109L,bilirubin 1.5ULN, alkaline phosphatase AP, aspartate transaminase AST and alanine transaminase ALT 2.5 upper limited numberULN AP, AST, ALT 5ULN is acceptable if liver has tumor involvement.INR1.5, APTT in the normal range 1.2DLN-1.2ULN,creatinine 1.5ULN. 