 Background: Severe sepsis and septic shock are the most common causes of mortality among critically ill patients and account for approximately 10 of admissions to the intensive care unit ICU and 3 of all admissions to hospital. Despite decades of therapeutic investigation, mortality of septic shock has remained at approximately 40-50. Fluid resuscitation is an integral component of early treatment, as several liters of fluid may be administered in the first hours of septic shock in an attempt to re-establish hemodynamic stability. The two main classes of fluid expand the plasma volume include crystalloids and colloids. 