 Work plan: The investigators intervention study will use a multi-centre, prospective, randomized, open procedure but blinded end-point PROBE design. Patients n220 are randomized 1:1 to either usual care n110 or intervention n110. Inclusion criteria are HFPEF 60 years. In the Intervention arm, all patients will be subject to systematic screening and optimal treatment of 12 most frequently seen co-morbidity. Endpoints will be collected by Independent Endpoint Committee once a year during 2 years. 