 The proposed study is a four-arm randomized control trial RCT in 48 villages in the Lakes region in Tanzania comparing the relative effectiveness of 4 vector control interventions for reducing malaria transmission and controlling vector populations in an area where An gambiae s.s is pyrethroid and carbamate resistant: 1 a standard long lasting insecticidal net LLIN, 2 a LLIN which incorporates a piperonyl butoxide PBO synergist, 3 a long lasting indoor residual spray IRS formulation used in conjunction with standard pyrethroid LLIN or 4 the long lasting indoor residual spray IRS formulation used in conjunction with the LLIN which incorporates a PBO synergist. 