 This study consists of three parts. Part 1 is Single Ascending Dose Including Food Effect and Drug-drug Interaction DDI with Itraconazole. There will be a washout between treatment period 1 and 2 in the DDI arm of Part 1; Part 2 is a Multiple Ascending Dose MAD; Part 3, with a treatment period 1, 2 and 3 is Proof of Pharmacology. There will be a washout between each treatment period 