 a. MDS fulfilling all the criteria below: i. International Prognostic Scoring System IPSS intermediate-2 or high risk MDS; or Revised International Prognostic Scoring System IPSS-R intermediate, high, or very high risk MDS ii. - relapsedrefractory disease iii. Requiring therapy based on the presence of one or more cytopenias Hb 10 gdL andor red cell transfusion dependence, platelets- 50,000μL, or ANC 1,000 μL or excess blasts 5 in the peripheral blood or bone marrow. 