 - Patients should have adequate organ function defined as follows: Absolute granulocytes 1,500mm3, hemoglobin 8 gdl, and platelets 100,000mm3. Serum bilirubin 1.5 x Upper Limit of Normal ULN, serum creatinine 1.5 mgdL, AST SGOT lessequal 2.5 x ULN, ALT SGPT lessequal 2.5 x ULN. 