 Interstitial CystitisBladder Pain Syndrome ICBPS afflicts 3 to 8 million women in the US. Symptoms of ICBPS reduce quality of life, suppressing both social well-being and physical function. The chronic pain, voiding dysfunction, sleep deprivation and associated co-morbid conditions interfere with relationships and employment with significant direct doctor visits, medication, surgery and indirect loss of productivity economic impact, currently exceeding 100 million per year.This proposal aims to move the science of chronic pelvic pain CPP from simple associations towards an investigation of cause and effect relationships. The investigators will determine whether the striking changes in autonomic nervous system responsiveness ANS-R contribute meaningfully to the pathogenesis of ICBPS. 