 The TBTC Study 31 is a phase 3, multicenter, international, randomized, controlled, open-label, 3-arm, non-inferiority trial that will enroll newly diagnosed, previously untreated participants with pulmonary TB. Two investigational regimens will be evaluated to determine if the duration of treatment for drug-susceptible pulmonary TB can be reduced compared to a standard rifampin-containing six month treatment regimen. In one investigational arm, the efficacy of the single substitution of rifapentine for rifampin for the 17 week regimen will be assessed. The second investigational arm will evaluate a rifapentine-containing regimen that also substitutes moxifloxacin for ethambutol and continues moxifloxacin for 17 weeks. The Study 31 primary efficacy endpoint is TB disease-free survival at 12 months after study treatment assignment. In addition, time to culture conversion will be assessed. The primary safety endpoint is the proportion of participants with grade 3 or higher adverse events during study drug treatment. This PKPD Study is a component of TBTC Study 31. 