 - Use of any drugs known to induce or inhibit hepatic drug metabolism examples of inducers: barbiturates, carbamazepine, phenytoin, glucocorticoids, omeprazole; examples of inhibitors: antidepressants SSRI, cimetidine, diltiazem, macrolides, imidazoles, neuroleptics, verapamil, fluoroquinolones, antihistamines within 30 days prior to administration of the study medication. 