 Subjects and methods:54 multiple sclerosis patients will be recruited in two outpatient rehabilitation clinics Azienda Ospedaliero- Universitaria di Ferrara and Azienda Ospedaliero-Universitaria Pisana. Informed consent will be obtained. Participants enrolled will be included in 2 different treatment groups: experimental group will receive 10 TOCT sessions over 2 weeks 2 hourseach session followed by a 3 months home exercise program, whereas control group will be included into a delayed-treatment group. Three subjects with a supervisor physiotherapist will take part at the TOCT. Primary outcome measure will be walking endurance Six Minute Walking Test; as secondary outcome we will test gait speed Timed 25-Foot Walk, balance Dynamic Gait Index and mobility Time Up and Go Test; through self-assessment questionnaires we will evaluate motor fatigue Modified Fatigue Impact Scale - MFIS, walking ability Multiple Sclerosis Walking Scale - 12, health-related quality of life Multiple Sclerosis Impact Scale - 29 and Functional Assessment of Multiple Sclerosis. In addition to clinical outcomes, in a convenience sample we will have: i balance assessment force platform; ii motorcortex oxygenation during walking fNIRS; iii muscle oxygenation NIRS; iv force and EMG signal; v mechanical and electrical fatigue assessment; vi brain connectivity EEG. Outcome measures will be assessed 1 week prior to treatment initiation T0, after two weeks to treatment initiation T1, after the 3 months exercise program T2 and at 3 months follow-up T3 to evaluate treatments retention, by a clinician blinded to the treatment. 