 This study is a randomized cross-over study. Normal fat diet ie 10 proteins, 45 lipids, 45 carbohydrates is the imposed diet at baseline, high fat diet ie 10 proteins, 30 lipids, 60 carbohydrates is used according to the cross-over design trial. Main evaluation criteria is REE and second evaluation criteria is DIT both measured by indirect calorimetry . 36 included MID subjects will be included in this study. Main evaluation criteria and second evaluation criteria will be measured at baseline, 1 month, 2 month and 3 month. 