 4. Histologically confirmed colon carcinoma, American Joint Cancer CommitteeUnion Internationale Contre le Cancer AJCCUICC Stage II or Stage III defined as a tumor location 15 cm from the anal verge by endoscopy or above the peritoneal reflection at surgery. The patient was not to be a candidate for neo adjuvant radiotherapy. Note: Stage II patients were to be considered as high-risk patients fulfilling one of the following criteria: 