 6. Onetwothree vessel disease as evidenced either by an angiographic documentation of advanced atherosclerotic narrowing of 60 of at least one major epicardial coronary artery right coronary artery RCA, left circumflex LCX, or LAD or any of their branches, or of diffuse type of CHD as evidenced by the appearance on coronary angiography of multiple stenoses, multiple atherosclerotic plaques, andor peripheral occlusions of coronary vessels with and without a history of MIs. 