 Statistical analyses Results will be summarized as mean and standard deviation SD for quantitative variables and as frequency tables for categorical findings at each time point. Longitudinal data will be displayed graphically and analyzed by the general linear mixed model which accounts for repeated values within patients. Success rates will be estimated and associated with 95 confidence intervals 95CI. The significance level will be set at 5 P0.05. Data will be analyzed with Statistical Analyses Software SAS and S-PLUS softwares. 