 Over the past three years, this electronic devices Tobacco Free Cigarettes, or TFC has been an important expansion in many countries. Nevertheless, there is poor evidence that TFC are beneficial for smoking cessation. In particular, even though it has been proved that the nicotine replacement devices helps many individuals to give up smoking and to tolerate the withdrawal symptoms, it is still unclear their long-term effect. Hence, it must be tested its contribution in tobacco reduction. This protocol in particularly innovative, since it aims to test the efficacy of electronic devices in a screening program the lung cancer prevention program COSMOS II at the IEO, where tobacco reduction is strictly needed in order to lower individuals risk. 