 Aims: The aim of this randomized, controlled trial RCT is two-fold: firstly, to assess the effectiveness and cost-utility of MBSR added to treatment as usual TAU; and secondly, to evaluate the effects of the compared interventions on neurobiological parameters. Specifically, MBSR will be compared to an active control which was previously reported as a cost-effective intervention TAU FibroQol psycho-educational program; Luciano et al., 2013 and also vs. TAU alone in a 12-month follow-up RCT. Brain structure and function of pain-relevant areas and levels of inflammation markers cytokines will be assessed pre-post interventions in half of the study participants. 