 - Therapeutic level dosing of warfarin can be used with close monitoring of PTINR by the site. Exposure may be decreased due to enzyme induction when on treatment, thus warfarin dosing may need to be adjusted based upon PTINR. Consequently, when discontinuing dabrafenib, warfarin exposure may be increased and thus close monitoring via PTINR and warfarin dose adjustments must be made as clinically appropriate. Prophylactic low dose warfarin may be given to maintain central catheter patency. 