 - Symptomatic brain metastases. Patients with untreated brain metastasis 1 cm can be considered eligible if deemed asymptomatic by the investigator upon consultation with the Medical Monitor and do not require immediate radiation or steroids. Patients with brain metastasis that is treated and stable for 1 month may be considered eligible if they are asymptomatic and on stable dose 2 weeks of steroids or if they do not require steroids following successful local therapy. 