 A study physician and genetic counselor will disclose the infants randomization assignment and study results during an in-person consultation with each family. The study physician and genetic counselor will provide the consultation to families utilizing all available medical information. In the sequencing arm of the study, this will include the medical history, physical exam, family history, standard newborn screening NBS report and sequencing reports. In the non-sequencing arm of the study, this will include the medical history, physical exam, family history and standard NBS report. 