 Objective of study : The aim of this study was to compare general anesthesia GA and combined epidural and spinal anesthesia CA for laparoscopic cholecystectomyLC.Laparoscopic cholecystectomies are usually performed under general anesthesia. Studies involving cholecystectomies with regional anesthesia recently published. During regional anesthesia pneumoperitoneum is performed with lower pressure10mmHg CO2. Patients can not tolerate higher intraabdominally pressure. Thera are very few studies involving the effect of pneumoperitoneum on coagulation factors. In our study the investigators separate the patients into 2 groups. Group1:10 mmHg pressure, laparoscopic cholecystectomy under general anesthesia ; Group2 : 10 mmHg pressure, laparoscopic cholecystectomy under Combined Spinal-Epidural Anesthesia The investigators performed standard conventional laparoscopic cholecystectomy procedure with 10mmHg pressure in both groups. The investigators aimed to investigate Prothrombin TimePT, activated partial thromboplastin timeaPTT, thrombin timeTT, D-dimer and fibrinogen levels preoperative, postoperative 1st hour and 24th hour respectively. 