 OUTLINE: This is a randomized, double-blind, placebo-controlled, multicenter study. Patients are stratified according to prior platinum-containing treatment yes vs no. Patients who received prior treatment are further stratified according to prior cumulative platinum exposure cisplatin 200 mgm2 or oxaliplatin 750 mgm2 vs cisplatin 200-399 mgm2 or oxaliplatin 750-999 mgm2 vs cisplatin 400 mgm2 or oxaliplatin 1,000 mgm2. Patients are randomized to 1 of 2 treatment arms. 