 This drug occasionally causes severe adverse events AEs, which include hand-foot skin reaction HFSR, hypertension, diarrhea, anorexia, fatigue, weight loss, and so on. Although most adverse events are reversible, they can significantly impact a patients quality of life and occasionally result in dose reduction or discontinuation of therapy Patients are also more likely to remain on treatment if they are guided over the difficult initial 46wks of therapy during which time the development of adverse events following sorafenib treatment initiation are most likely to occur. 