 - Conditions other than IC of significant severity that could confound PWT on the standardized exercise treadmill test causing premature or inconsistent termination of exercise e.g., angina pectoris, heart failure New York Heart Association NYHA Classes III and IV, respiratory disease e.g., chronic obstructive pulmonary disease, orthopedic disease, neurological disorders, rheumatologic disorders e.g., severe degenerative joint diseases, dyspnea, fatigue, prior lower limb amputation, including amputations proximal to the metatarsal or phalangeal joints. 