 The phenomenon that oral glucose elicits a higher insulin response than does intravenous iv glucose, even at identical plasma glucose PG profiles isoglycemia, is called the incretin effect. In type 2 diabetes mellitus T2DM the incretin effect has been shown to be markedly reduced or even abolished. It is not known whether the reduced incretin effect in T2DM is a primary event leading to T2DM or if it is merely a consequence of the diabetic state. To answer this question the investigators plan to estimate the incretin effect in 8 patients with secondary diabetes mellitus DM to chronic pancreatitis CP and compare it to the incretin effect of 8 patients with CP and normal glucose tolerance NGT. Eight patients with T2DM and 8 healthy control subjects are studied for comparison. The incretin effect is measured by a 50-g oral glucose tolerance test and an isoglycemic intravenous glucose infusion. 