 17. Have abnormal Vital Signs defined as: systolic Blood Pressure BP 140 mmHg andor diastolic BP 90mmHg, heart rate 45 beatsmin and 100 beatsmin. Even if one or more vital signs are out of the acceptable ranges, a subject may still be included in the study based on Investigators judgment e.g. a resting heart rate 45 in highly-trained athletes. Presence of any febrile illness including oral temperature OT 38.0 C within 24 hours prior to immunization. Such subjects may be re-evaluated for enrolment after resolution of illness. 