 Prognostic models, which have been produced based on clinical, histological and biochemical feature, are useful in predicting survival and determining timing for liver transplantation. Preliminary feasibility studies in patients with PSC using high resolution CT with a contrast agent CT cholangiography, has shown excellent depiction of bile ducts. CT cholangiography also has the potential to allow quantification of intraductal volume by using sophisticated computer programs. This assessment may be an important clinical feature to assess disease severity and progression.The information about cholangiographic features could be important for therapeutic decisions e.g., in determining the usefulness of balloon dilatation or stenting for a dominant extrahepatic duct stricture, for counseling patients, and for therapeutic trials in stratifying patients and assessing efficacy of treatment. 