 1 Age 2 Gender 3 Ethnicity 4 Reflux symptoms 5 Smoking 6 Alcohol 7 Dietary fat 8 Dietary fiber, vegetables, fruits 9 Dietary calcium 10 Obesity 11 Family history of reflux, BE or esophageal cancer 12 Use of aspirin, non-steroidal anti-inflammatory drugs 13 Use of lower esophageal sphincter relaxing medications 14 Use of acid suppressive medications 15 Cholecystectomy 16 Anti-reflux surgery fundoplication 17 Length of BE 18 Hiatal hernia 19 Helicobacter pylori infection 20 Low-grade dysplasia on biopsy This proposal will make it feasible to narrow on the factors to be studied in the prospective trial. 