 6. Patients must have WBC 4000 cellsmm3, ANC of 1500L, platelets 100,000mm3, total serum bilirubin 2.0 mg, BUN 30 mg, creatinine 1.5 mg andor creatinine clearance 30mlmin estimated as calculated with Cockcroft-Gault equation. Note: In patients with moderate renal impairment estimated creatinine clearance 30-50 mLmin at baseline, a dose reduction to 75 of the capecitabine starting dose is recommended. 