 This will be a randomized, placebo-controlled, double-blinded study. Seventy-two men and 72 women, over 60 years old, who are healthy, will be randomized to receive either a replacement dose of DHEA or placebo for 1 year. The replacement dose of DHEA will bring circulating DHEA sulfate DHEAS levels into the range of normal in healthy 20-30 year-old women approximately 8 micromoles per liter μM or 295 micrograms per deciliter μgdL and men approximately 10 micromoles per liter μM or 368 micrograms per deciliter μgdL. 