 - History of liver disease, clinically significant cardiac disease, renal disease or pulmonary disease other than asthma. Patients with clinically significant laboratory abnormalities of LFTsbilirubin ASTALT, TBili, alkaline phosphatase and clinically significant anemia will be excluded. Clinically significant anemia will be defined as any anemia resulting in serum Hgb more than 1 gmdl below the LLN, Patients with isolated minimal elevations of bilirubin eg. as occurs in Gilberts disease or minimal elevations in transaminases less than 1.2 x ULN without a history of liver disease, risk factors for liver disease or symptoms of liver disease may still be included in the study at the investigators discretion, but will have LFT testing at each study visit. 