 2. Willing to discontinue all analgesics e.g. NSAIDS, COX-2 inhibitors, acetaminophen, aspirin 81 mgday, short-acting muscle relaxants i.e. carisoprodol, Soma, and herbal remedies for pain at least 24 hours prior to first dose and to refrain from use during the study cardio-protective doses of aspirin 81 mg day are allowed. 