 The proof of concept that malignant cells from the upper genital tract get transported even into the lower genital tract was recently published by Kinde I. et al. 2. Liquid-based cervical cytology allows not only cytological evaluation but also collection of DNA. A panel of genes that are commonly mutated in endometrial and ovarian cancers was assembled with new whole-exome sequencing data from 22 endometrial cancers and previously published data on other tumor types, including mutations in the TP53 gene. This panel was used to search for mutations in 24 endometrial and 22 ovarian cancers and identified mutations in all 46 samples. Aiming at establishing a possible screening test for EOC and EC, tumor cells were searched for in the DNA obtained through liquid Pap smear. With a sensitive massively parallel sequencing method, it was possible to identify the same mutations in the DNA from liquid Pap smear specimens in 100 of endometrial cancers 24 of 24 and in 41 of ovarian cancers 9 of 22. 