 1. Epidemiological factors From the baseline study, most patients do not interrupt treatment during the intensive phase of treatment. But, the occurrence of death is high during the first 2 months of treatment. Even though its contribution is unknown in Ethiopia, the high HIV-TB co-morbidity and mortality during anti-TB therapy has been attributed in other sub-Saharan countries. Thus, proper management in health facilities during the first 28 days for patients assigned into volunteer CHW care or self-administered groups would ensure their health care needs. 