 Hemophilia A is an X-linked recessive, congenital bleeding disorder caused by deficient or defective coagulation factor VIII FVIII. The absence or severe reduction of FVIII leads to spontaneous bleeding episodes occurring primarily in joints, muscles, and less commonly, in soft tissues and to excessive bleeding following trauma or injury. Estimations based on the WFHs annual global surveys indicate that the number of people with hemophilia in the world is approximately 400,000. 1 China accounts for a quarter of about 100,000. 