 A DLT is defined as: 1 any Grade 3 or higher adverse event AE per National Cancer Institute NCI Common Terminology Criteria for Adverse Events CTCAE for which there is reasonable possibility that salsalate caused the event, 2 any Grade 2 AE in the CTCAE system organ class of nervous system disorders that is considered clinically significant and for which there is reasonable possibility that salsalate caused the event, or 3 any Grade 2 or higher treatment-related adverse events during administration that do not resolve promptly with supportive treatment. 