 All registered patients will be treated with 6 monthly courses of chemotherapy. First three ones will be a CHOP regimen with half dosage of adriamycin, as previously published Effectiveness of CHOP regimen in advanced untreated chronic lymphocytic leukemia. French Cooperative Group on Chronic Lymphocytic Leukemia. Lancet ; 1986, i : 1346-1349, followed by three subsequent courses with IV fludarabine 25 mgsqm d1-5. Patients in CR NCI, 1996, including CAT scan evaluation will be then randomized to surveillance without additional treatment or autologous stem cell transplantation using peripheral stem cells collected after the three first courses of chemotherapy, andor after the completion of the six courses when necessary. For patients not in CR after the six courses, a rescue regimen with the DHAP association cisplatin, 100 mgsqm d1, cytarabine 2 gsqm d2, dexamethasone 40 mgsqm d1-4 will precede an additional stem cell collection if necessary, and patient will be randomized between autologous stem cell transplantation and three additional courses of an association of fludarabine 25 mgsqm d1-3 and cyclophosphamide 300 mgsqm d1-3. Conditioning regimen will associate TBI 10 grays, d -3-1 and cyclophosphamide 60 mgsqm d-5-4. 