 Wolman disease is a rare genetic disorder characterized by complete absence of an enzyme known as lysosomal acid lipase LIPA or LAL. This enzyme is required to breakdown metabolize lipids in the body. Without the LIPA enzyme, lipids may abnormally accumulate in the tissues and organs of the body causing a variety of symptoms. Wolman disease may cause bloating or swelling of the stomach abdominal distention, vomiting, and significant hepatosplenomegaly. Life-threatening complications often develop during early childhood. Wolman disease is caused by mutations of the lysosomal acid lipase LIPA gene. The disorder is inherited as an autosomal recessive trait.Wolman disease is the most severe expression of LIPA deficiency. Milder forms of the disorder are known as cholesteryl ester storage deficiency. The symptoms of Wolman disease usually become apparent shortly after birth, usually during the first few weeks of life. Affected infants may develop bloating or abdominal distention and may have significant hepatosplenomegaly. Fibrosis of the liver may also occur. In some cases, fluid may accumulate in the abdominal cavity ascites.Infants with Wolman disease have serious digestive abnormalities including malabsorption, a condition in which the intestines fail to absorb nutrients and calories form food. Malabsorption associated with Wolman disease causes persistent and often forceful vomiting, frequent diarrhea, foul-smelling, fatty stools steatorrhea and malnutrition. Because of these digestive complications, affected infants usually fail to grow and gain weight at the expected rate for their age and sex failure to thrive. 