 At baseline screening, informed consent will be obtained and skin will be examined for potential non-melanoma skin cancers. Any lesions that are clinically suspicious for non-melanoma skin cancer will be removed per standard of care prior to administration of drug. Actinic keratoses will not be removed during the 28 day study period. Two weeks later, once any lesions clinically suspicious for non-melanoma skin cancer have been removed, renal transplant recipients will be randomized to one of the treatment arms described above. Participants will return at 28 days and 112 days for assessment. 