 9. Serum bilirubin 1.5 mgdl and Cr Clearance 30 mLmin, Aspartate transaminase AST serum glutamic oxaloacetic transaminase SGOT and Alanine transaminase ALT serum glutamic-pyruvic transaminase SGPT 2 x upper limit of normal or 5 x upper limit of normal if hepatic metastases are present. Gilberts disease is allowed. 