 6.Inadequate hematopoietic function: Hemoglobin90gL; ANC1,500mm3;Platelet100,000mm3 7.Inadequate organ function which is defined as below: Total bilirubin1.5 pper limit of normal range ULN; ALT AST2.5 upper limit of normal range ULN 5.0 x ULN if hepatic metastasis; serum creatinine1.5 pper limit of normal range ULN, Serum albumin30gL. 