 - Clinically active brain metastases defined as untreated, symptomatic or requiring steroids or anticonvulsants medications to control associated symptoms, uncontrolled seizure disorder; spinal cord compression; or carcinomatous meningitis. Subjects with treated brain metastasis will be included in the study if they have recovered from the acute, toxic effects of radiotherapy. A minimum of 15 days must have elapsed between the end of RT and the screeningbaseline visit 