 Conventional laser photocoagulation has been shown to be beneficial in a variety of retinal diseases like age related macular degeneration AMD, diabetic maculopathy DMP, diabetic retinopathy DRP or central serous retinopathy CSR. There are several hints that the positive effect is mediated by the RPE. The RPE is the main target of laser energy due to its high amount of melanosomes and absorbs about 50 to 60 of the energy applied to the retina. Today conventional retinal laser treatment is performed using the continuous-wave argon laser 514 nm. Generally the exposure times are longer than 50 ms, typically 100 to 200ms. After application of the laser energy onto the retina usually an ophthalmoscopically visible grayish-white lesion results from thermal heat conduction. Histologically a destruction of the RPE, which is the primary absorption site, occurs, leading to an irreversible destruction of the outer and inner segments of the neuroretina due to thermal denaturation. 