 2. With abnormal organ functions such as absolute neutrophil count ANC 1500 μL, hemoglobin 9 gmdL, platelets 50,000 μL, creatinine 2 mgdL, alanine aminotransferase AST or ALT 5 X upper normal limit of the current institution; bilirubin 2.5 mgdL, prothrombin time PT prolongation 4 sec above upper limit of normal 