 The goal of this study is to determine whether stimulation of HBO1 HAT activity by E1A i enhances initiation ii induces qualitative and quantitative changes in acetylation of H4 K5, K8 and K12 at the origin region, and iii enhances re-replication that occurs in E1A cells. If increased HAT activity can stimulate one or more of these functions, it could explain how this property of E1A would contribute to the induction of aberrant DNA replication. 