 Specifically, the purpose of this study is to assess the influence of end-stage renal disease ESRD on area under the curve both area under the curve, from time 0 to the last concentration measured AUC0-last and area under the curve, from time 0 extrapolated to infinity AUC0-inf of carfilzomib 56 mgm2 at Cycle 2 Day 1 C2D1 in patients with relapsed multiple myeloma. 