 - Course 3: Depending on whether or not patients are experiencing dose-limiting or intolerable toxicities, they are escalated to dose level 0 or dose level 2 patients in both dose levels receive oral sorafenib tosylate twice daily in weeks 9-12, or de-escalated to dose level 0 or dose level -2 patients in dose level -2 receives oral sorafenib tosylate once every other day in weeks 9-12. 