 - Patients with combined extramedullary ALL are eligible if extramedullary disease has been successfully cleared by conventional therapy at the time of inclusion e.g. intrathecal chemotherapy, orchiectomy. This includes patients with combined CNS-2 5 WBCμl CSF, with blasts on cytospin or CNS-3 5WBCμl CSF, with blasts on cytospin disease and patients with combined testicular relapse. 