 This studys procedures include screening, preparatory meetings, psilocybin sessions, and follow-up assessments. A large battery of behavioral and psychological measures will be assessed throughout. The study team will consent and enroll up to 86 subjects to obtain a total of 12 completer participants as well as 2-3 family members or friends per study participant who can assess said completers on the Observer Rating Form COM-R. This number will account for screen-failures and dropouts as well. The 12 participants will be randomly assigned to either an immediate participation group N6 or a 6-month delayed participation group N6. Although statistical power calculations show that 12 participants will be sufficient to detect the major effects anticipated in this study, the sponsor of this study The Council on Spiritual Practices is concurrently funding Johns Hopkins University School of Medicine to conduct a methodologically identical study with 12 additional participants IND 59009. This will permit the two sites to collaborate post study completion and combine the data from the two studies to provide statistical power to detect even more subtle effects of the psilocybin intervention. Twelve volunteers 6 from each group will participate at Johns Hopkins and 12 at New York University. Randomization and data analysis will be conducted at New York University. 