 - Have taken a known moderate or strong inhibitorinducer of cytochrome P450 CYP3A4 and CYP2C9 or a dual inhibitorinducer of CYP3A4 and CYP2C9 within 14 days or after washout that is, duration of 5 times the drugs half-life before the first study drug administration on Day 1 until the follow-up visit. Fluvoxamine is a moderate CYP2C9 inhibitor and a mild CYP3A inhibitor, and will not be excluded from the study 