 The main purpose of this study is to examine the effects of infliximab on measures related to depression symptoms. Infliximab is also known by its brand name Remicade. Infliximab, or Remicade, is given by an intravenous IV needle and is currently used to treat rheumatoid arthritis and Crohns disease. Infliximab is thought to help these conditions because it reduces inflammation in the body. Infliximab Remicade reduces inflammation by blocking a chemical in the body called tumor necrosis factor TNF-alpha. This chemical produces inflammation. Inflammatory chemicals in the body like TNF-alpha appear to be increased in some people with major depression. Researchers believe that a drug like infliximab, which blocks TNF-alpha, may be helpful in treating depression. 