 A total of sixteen 16 adult male and female subjects will be enrolled. Renal Impaired Cohort: Eight 8 subjects with ESRD on HD. Healthy Match Control Cohort: Eight 8 healthy subjects with estimated creatinine clearance CLcr 90 mLmin. Subjects will be matched for age 15 years, BMI 15 , and gender 1:1 to the subjects in the ESRD cohort. 