 - Patients who take concomitant treatment with strong or moderate inhibitors of cytochrome P450 CYP 3A4 including oralsystemic ketoconazole, itraconozole, miconazole, clotrimazole, flucanazole, posaconazole, voriconazole, clarithromycin, erythromycin, ciprofloxacin, verapamil, diltiazem, indinavir, nelfinavir, saquinavir, ritonavir, amprenavir, lopinavir, atazanavir, darunavir and cyclosporine. 