 - Impaired renal function serum creatinine 1.2 mgdl, impaired hepatic function SGOTSGPT 2x upper limit of normal, impaired thyroid function Thyroid Stimulating Hormone TSH outside normal limits: This exclusion is based on a theoretical possibility of activation of underlying cellular metabolic abnormalities by sulforaphane. Current infection or treatment with antibiotics: this exclusion is to avoid complications of inter-current illness that may occur due to the clinical trial or obscure possible effects of sulforaphane. 