 5. Known contraindication to use of either lithium or quetiapine: known hypersensitivity of lithium or quetiapine or any of their excipients; severe renal insufficiency impairment; untreated hypothyroidism; severe cardiac disease insufficiency; low sodium levels e.g. dehydrated patients or those on low sodium diets; Addisons disease; Brugada syndrome or family history of Brugada syndrome; the rare hereditary inborn errors of metabolism galactosaemia, the Lapp lactase deficiency or glucose-galactose malabsorption; concomitant administration of cytochrome P450 3A4 inhibitors; or previously diagnosed QT prolongation. 