 - Currently during past 30 days from the signing of the informed consent document engaged in opioid agonist, partial agonist, or antagonist treatment; or require on-going prescription or over the counter OTC medications that are clinically relevant CYP P450 3A4 inducers or inhibitors e.g., rifampicin, azole antifungals e.g., ketoconazole, macrolide antibiotics e.g., erythromycin. See Appendix 12 for an excluded medications list. 