 All pharmacokinetic data will be analyzed in a population pharmacokinetic model using the Non Parametric Adaptive Grid with adaptive γ NPAG program of Leary, Schumitzky and Jelliffe.5 Upon obtaining model convergence, the mean parameter vector and covariance matrix from the population pharmacokinetic analysis will be embedded in Subroutine Prior of the ADAPT II package of programs of DArgenio and Schumitzky.6 