 3. Myeloma-related organ dysfunction at least one of the following C Calcium elevation in the blood serum calcium 10.5mgdl or upper limit of normal R Renal insufficiency serum creatinine 2mgdl A Anemia hemoglobin 10gdl or 2g normal B Lytic bone lesions or osteoporosis AND have measurable disease as defined by the following; IgG multiple myeloma: Serum monoclonal paraprotein M-protein level greater than or equal to 1.0 gdL or urine M-protein level greater than or equal to 200 mg24 hours IgA multiple myeloma: Serum M-protein level greater than or equal to 0.5 gdL or urine M-protein level greater than or equal to 200 mg24 hours IgD multiple myeloma: Serum M-protein level greater than or equal to 0.05 gdL or urine M-protein level greater than or equal to 200 mg24 hours Light chain multiple myeloma: Serum M-protein level greater than or equal to 1.0 gdL or urine M-protein level greater than or equal to 200 mg24 hours IgM multiple myeloma IgM M-protein plus lytic bone disease documented by skeletal survey plain films: Serum M-protein level greater than or equal to 1.0gdL or urine M-protein level greater than or equal to 200mg24hours 