 9. Patients will be allowed to have prior biologic i.e. VEGF, EGFR, etc. therapy. However, the patient will be excluded from a given study if heshe has received the same therapy as the clinical trial i.e. If a patient has been previously treated with bevacizumab, they are allowed to enroll in any of the 4 studies. If a patient has been previously treated with erlotinib, they are excluded from the clinical trials with erlotinib. In addition, if a patient has been previously treated with gefitinib Iressa, they are excluded from the clinical trials with erlotinib. 