 The aim of this study is to investigate associations between early structural cellular injury and microvascular alteration with progression of septic organ dysfunction according to total SOFA-Score an ICU-scoring system - the Sequential Organ Failure Assessment Score. Patients will be monitored for renal TIMP-2, IGFBP7, and intestinal biomarkers plasma i-FABP in conjunction with kidney and muscle vascular bed microvascular perfusion analysis assessed by contrast-enhanced ultrasonography CEUS. In parallel, a comprehensive analysis of patients immunological status will be conducted using an established, on-site immune monitoring panel. 