 The goal of this study is to understand how and why insulin resistant individuals respond differently to exercise as compared with insulin sensitive individuals at the skeletal muscle and gene expression level. The study has four aims including testing if MZF1, NFKB1, RELA, SP1KLF and EGRI expression responses are outside of the normal range in insulin resistant individuals and how insulin resistance changes the cell biosynthesis process post translational modifications. It also aims to define the response of MiRNAs in healthy and insulin resistant individuals and determine if treatment with Gemfibrozil inhibits transcription processes. 