 - Age range 14-70 years old; ECOG performance status 0-2; Estimated survival time 3 months Histological confirmed Diffuse large B cell lymphomaIIIIV None of chemotherapy or radiotherapy has been previously used None of chemotherapy contraindication: hemoglobin 90 gdl, neutrophil 1.5×109L, platelet 100×109L, ALT and AST 2×ULN, serum bilirubin 1.5×ULN, serum creatine 1.5×upper limitation of normal ULN, Serum Albumin 30gL At least one measurable lesion None of other serious diseases, cardiopulmonary function is normal Pregnancy test of women at reproductive age must be negative Patients could be followed up None of other relative treatments including the traditional Chinese medicine, immunotherapy,biotherapy except anti-bone metastasis therapy and other symptomatic treatments. 