 Again, in this proposed study, the sample size is relatively small, but based upon the results of earlier studies of TMS, effect size is projected to be a value greater than zero in the population under consideration and the greater this nonzero value is, the greater the probability that TMS or standard medication therapy is manifesting the effect being hypothesized. This is entirely consistent with the Bayesian design of experiments in which the outcomes of earlier studies influence the design of the proposed clinical trial of TMS and standard medication therapy. 