 7. Patients must have the following clinical laboratory values: Serum creatinine 2.0 mgdl. ; Serum bilirubin 1.5 mgdl; Platelet count 50,000mm3; Absolute neutrophil count ANC 1,000mm3; Alanine aminotransferase ALT, or aspartate aminotransferase AST 2 x upper limit of normal or 5 x upper limit of normal if hepatic metastases are present. 