 Oral SCIO-469 given for 16 weeks to patients with MDS. Subjects will receive a total daily dose of SCIO-469 of 90 mg, 180 mg, 270 mg, or 360 mg. The treatment arms will be 30-mg tablet tid, 60-mg tablet tid, 90-mg tablet tid, or 120 mg i.e., two 60-mg tablets tid with 15 subjects per arm total of 60 subjects. Responding subjects may dose for up to 104 weeks total drug exposure. 