 - Known or suspected congestive heart failure NYHA I andor coronary heart disease, angina pectoris requiring anti-anginal medication, previous history of myocardial infarction 6months, evidence of transmural infarction on ECG, un- or poorly controlled arterial hypertension i.e. BP 150100 mmHg under treatment with two antihypertensive drugs, rhythm abnormalities requiring permanent treatment, clinically significant valvular heart disease. 