 - Cardiovascular disease, including recent history of or currently clinically symptomatic and uncontrolled congestive heart failure, arrhythmia, angina, QTc prolongation or other QTc risk factors, myocardial infarction. Patients with CTCAE grade 2 cardiac arrhythmias may be considered for inclusion if the arrhythmias are stable, asymptomatic, and unlikely to affect patient safety. Patients will e excluded if they have ongoing cardiac dysrhythmias of CTCAE grade 3, corrected QT interval QTc prolongation 450 ms, or other factors that increase the risk for QT interval prolongation e.g., heart failure, hypokalemia defined as serum potassium 3.0 mEqL that is persistent and refractory to correction, or family history of long QT interval syndrome. 