 Baseline tests will include CMR evaluation of ventricular function using a magnetic field strength of 1.5 Tesla T. The initial scan will assess ventricular size and function and LV mass. Blood tests will be taken prior to the scan at the time of intravenous cannulation for urea and electrolytes, liver function, cytokines, and collagen markers. In addition, echocardiograms, 24 hour Holter monitors will be fitted and metabolic exercise tests MVO2 will be performed as part of the cardiac assessment at baseline, 6 and 12 months. 