 - Participants having painful symmetric neuropathy a disturbance in the function of the brain or spinal cord that may affect the nerves and muscles of the body in the lower limbs applicable to both of the following conditions: decreased sensation of leg to monofilament, none or decreased ankle reflexes or decreased vibratory sensation and pain symptoms such as numbness loss of sensation, tingling, paresthesia a skin sensation, such as burning, prickling, itching, or tingling, with no apparent physical cause, burning, shooting pain, stabbing or lancinating characterized by a sensation of cutting, piercing, or stabbing pain 