 There are several intervention programs involving multisensory and motor stimulations such as, gym, auditory, visual, vestibular and tactile stimulations. We propose to study a continuous program of early intervention involving very preterm infants families in their first 12 months of life taking the chance of their neuronal plasticity during this period. Preterm infants born in our institution will be included when they complete 48 hours after birth first intervention. All preterm infants and their mothers will be followed during neonatal period and pre hospital discharge they will have a second intervention to measure parental bond . After discharge they will be conducted to follow up program and we will divided all very low birth weight infants included in the study in two groups according previous randomization: 