 To avoid infection: During bone marrow aspiration, procedure will be done under complete aseptic precautions, placed in sterile tubes containing pre-servative-free heparin Sigma-Aldrich, St. Louis, USA Separation and processing of the sample will be done under good manufacture procedure GMP: Bone Marrow Aspirate BMA will be withdrawn under good sterilization of the skin in an isolated area. Processing of the sample will be done in the laminar air flow; all supplies are disposable and sterile. 