 This is a 19-week, multi-center, randomized, Phase 2 clinical study comparing the efficacy of lorcaserin 10mg, b.i.d to matched placebo in the treatment of cocaine use disorder. Up to 3 weeks will be allowed for the Screening Period and a 13-week treatment phase, with a 3-week follow-up period, with scheduled visits during Study weeks 14 and 16. 