 - Participant has evidence of any brain diseases, other than potential very early signs of Alzheimers Dementia AD example. mild hippocampal atrophy or typical age-related changes e.g. mild white matter hyperintensity on magnetic resonance imaging MRI or any other abnormality e.g. folic acidVitamin B12 deficiency that could explain a possible cognitive deficit including, but not limited to vascular encephalopathy or large strokes as imaged by cerebral MRI 