 - High risk of intracranial hemorrhage, as determined by 1 of the following: 1 intracranial or spinal pathology which places individuals at risk for intracranial hemorrhage e.g., arterio-venous malformation or previous intracranial bleeding events, not including meningitis; 2 acute change in neurological status with focal neurological findings; 3 documented intracranial hypertension by lumbar puncture or imaging; or 4 seizures in which there is a clinical suspicion of intracranial hemorrhage 