 The present study is a single-centered Sapporo Medical University Hospital, observational study enrolling patients who will be admitted to our institute for coronary angiogram. Written informed consent will be obtained from patients on admission. Patients will receive demographic measurements, blood sampling for routine serum biochemistry and detailed analyses of serum lipids such as apolipoproteins, remnant-like lipoprotein particle and oxidized-LDL-cholesterol after overnight fast and oral glucose tolerance test OGTT. In OGTT, blood will be sampled for assay of glucose, insulin, active GLP-1 and total GLP-1 before, 30 min, 60 min, and 120 min after oral 75 g-glucose loading. Capacity of GLP-1 secretion will be determined as area under the curve of plasma GLP-1 level AUC-GLP-1. All study subjects will undergo coronary angiogram and severity of coronary artery stenosis will be quantified by Gensini score GS. Relationship between GS, AUC-active-GLP-1 or AUC-total-GLP-1, blood pressure, serum lipid parameters, and indices of insulin resistance homeostasis model assessment as an index of insulin resistance and Matsuda-Defronzo index will be examined by use of univariate and multivariate regression analyses to determine whether AUC-active-GLP-1 or AUC-total-GLP-1 is an independent determinant of coronary artery stenosis. This study will be conducted as one of projects in BOREAS registry, a non-interventional, multicenter registry of cardiovascular andor renal diseases conducted by our institute and affiliated hospitals. 