 To determine whether high-protein 24 of total calorie from protein enteral nutrition of immune modulating nutrients eg, ω-3 fatty acids and antioxidants enriched with β-glucan stimulates immune functions compared with standard enteral nutrition control: 20 of total calorie from protein or high-protein 24 of total calorie from protein enteral nutrition of immune modulating nutrients without β-glucan in critically ill patients. In a randomized double-blind placebo-controlled study, 30 patients consumed 1 of 3 enteral nutrition: control, enteral nutrition of immune modulating nutrients enriched with β-glucan 250mgL or enteral nutrition of immune modulating nutrients without β-glucan. Enteral nutrition was initiated within 24 hours of ICU admission and continued during the ICU stay for a 7 days. 