 People who acquired HIV disease in the first decade of life and who have evidence of central nervous system CNS disease e.g., encephalopathy, CNS compromise, ADHD, bipolar disease, major depression or psychosis may be eligible for this study. Candidates are screened with a medical history, physical examination, neuropsychological testing and a CT scan of the head, if one has not been done within 12 months of entering the study. 