 7. Have adequate cardiovascular function as defined by: i a normal beta-natruetic peptide BNP with ii no signs or symptoms suggestive of cardiac disease and iii a normal Electrocardiography ECG. Alternatively, patient not meeting all of these criteria is still eligible if he has both i an echocardiogram showing an ejection fraction EF of 45 or greater and no more than mild diastolic dysfunction and ii a Brain Natriuretic Peptide BNPof 200 