 Study population II ,according to the same proportion ,are randomly divided into four group in double blinded state,: 5μgml ESAT6-CFP10 after BCG immunization, 10μgml ESAT6-CFP10 after BCG immunization, 5μgml ESAT6-CFP10 after placebo-controlled immunization , 10μgml ESAT6-CFP10 after placebo-controlled immunization.They vaccinate BCG or the placebo of BCG. 