 A randomized multicenter trial will be conducted in 4 sites in Africa Benin, Gabon, Tanzania and Mozambique in order to compare the safety and efficacy of SP versus MQ as IPTp in the context of ITNs. In addition, MQ tolerability will be also evaluated by comparing the administration of MQ as a single intake with its administration as split dose in two days. In total 4716 pregnant women will be enrolled at the antenatal clinic ANC and will be followed until the infant is one year old. 