 MechanisticPharmacological rationale of benefit expected The use of Tirofiban, given at single high dose bolus, is expected to act on the final common pathway of platelet activation, thus it will completely bypass the COX-1 mediated signal activation the intracellular pathway on which Aspirin-mediated platelet inhibition is based on. The use of SHDB Tirofiban will result in a dramatic inhibition of platelet activation compared to patients treated with aspirin and clopidogrel alone, determining a significant and profound increase in platelet function which is in contrast to the TACTICS dose10. 