 i. Has signs and symptoms of persistently active disease despite a history of at least one 12-week regimen of oral azathioprine 1.5 mgkg or 6-mercaptopurine 0.75 mgkg, OR ii. Has a history of intolerance including but not limited to nauseavomiting, abdominal pain, pancreatitis, liver function test abnormalities, lymphopenia, thiopurine S-methyltransferase non wild type where wild type is defined as thiopurine S-methyltransferase TPMT11, infection to at least 1 immunomodulator. 