 Endometrial biopsy and sampling will be performed at the end of the treatment course using a Pipelle Curette de Cornier, placed high into the upper fundus of the uterus. An aliquot of the endometrial sample will be pushed from the pipette into a polypropylene vial. The vial will be capped, immediately frozen, and then stored at -20o Celsius until shipping in dry ice to the Department of Pathology at the Vale do Sapucai University, directed by one of the authors, for measurement of Progestogen Receptor PR and Estrogen Receptor ER receptors as well as Bcl-2 protein. The remaining endometrial tissue will fix in 10 neutral buffered formalin for 6-48 h and then process into paraffin blocks. 