 Our preliminary data support this extrapolation. In n 3 Turner syndrome patients combining a transdermal E2 dose of 17.8 2.1 SD mcg for an average of 14 days a month with GH therapy for 1.0 year showed increases in breast tissue diameter of 1.8 0.3 cm i.e., breast budding, bone mineral density of 0.067 0.06 gmcm2 in the lumbar spine, and height velocity of 5.16 1.37 cmyear. The new VLTE2 14 mcg patch increases lumbar spine bone mineral density 2.4 at 1 year in post-menopausal women P 0.001, but no trials have been conducted in children package insert. 