 - Patients must have had prior systemically administered platinum-based chemotherapy; pleural space washing with cisplatin does not constitute systemic administration; no more than two prior systemic therapeutic regimens are allowed including biologics, targeted and immunotherapies, and at least one regimen must have been platinum-based; neoadjuvant andor adjuvant systemic therapy will not be counted as a prior regimen, assuming at least 12 weeks have elapsed between the end of neoadjuvantadjuvant therapy and development of progressive disease; patients must have completed systemic therapy including any chemotherapy, biologics, targeted and immunotherapies 28 days 42 days for nitrosoureas or mitomycin C prior to registration and have recovered from adverse events due to agents administered 