 The study will begin after approval by the Research Ethics Committee CEP of the AC Camargo Cancer Center. Each patient will sign a term of informed consent IC prior to study entry. The term was written in accessible laymans language the patient, following the ethical recommendations. Patients may withdraw from the study at any time, without prejudice to the proposed treatment. We declare the confidentiality of personally identifiable patient, it is not possible to identify it during analysis and publication of data. 