 Patients must have recovered from toxicity related to prior therapy to at least to grade 1 defined by the Common Terminology Criteria for Adverse Events CTCAE 3.0 until December 31, 2010, and by CTCAE 4.0 beginning January 1, 2011 and must not have had prior chemotherapy within 4 weeks. Patients must be at least 28 days since any prior radiation or major surgery. 