 Port wine stains are red birthmarks that without treatment persist for a lifetime. They are frequently found on the face and can be conspicuous and disfiguring, negatively impacting social interactions for these patients. Treating Port wine stains is difficult. The standard of care is to use laser treatment, but over 80 of patients fail to completely clear despite multiple treatments. The growth of additional blood vessels angiogenesis following the Laser treatment is likely an important factor in why these lesions persist despite therapy. 