 The patients would receive TPF induction chemotherapy followed by radical surgery and post-operative radiotherapy the experimental group or radical surgery and post-operative radiotherapy the control group. The study had a power of 80 on the basis of an assumed 5-year survival rate of 85 in the experiment group and 66 in the control group, with use of a two-sided log-rank test at a level of significance of 0.05. The recruitment period would be 2 years, and the follow-up period would be 5 years, and 15 of patients would drop out early or be lost to follow-up. A maximum of 36 patients per group were to be recruited with stplan 4.5 software calculation. Department of Biostatics, MD Anderson Cancer Center, University of Texas,USAThe patients in the experimental group received the TPF induction chemotherapy for 2 cycles followed by radical surgery and post-operative radiotherapy. The palpable edges of the primary lesion both the longest and shortest axis were marked before induction chemotherapy by at least four points, which were 0.5cm away. The patients in the control group received the radical surgery and post-operative radiotherapy. 