 Statistical analysis The BCVA obtained during each visit was converted from decimal to logarithm of the minimum angle of resolution logMar for calculation. Chi-square test were used to Compare the baseline data including age, sex, eye. Mann-Whitney-U test was used to compare the difference of age, and average number of injections per year between the 2 groups. Mann-Whitney-U test, Wilcoxon test and independent t-test were used for the comparison of BCVA at different time points in each group. Patients were also divided according to their initial BCVA 1.0 or 1.0 in logMar, or age 70 or 70 years of age to see whether initial BCVA or age play a role in the visual changes. A p-value of less than 0.05 was accepted as statistically significant. All the analyses were performed using SPSS software package ver. 23.9; SPSS Inc., Chicago, illinois, USA. 