 150 HCC patients with tumor 5cm, multiple tumor and who cannot accept R0 resection will be randomized divided into 3 groups. Group A 50 cases will be implanted 600mg sustained released 5-FU into liver incisal margin after tumor is resected. Group B 50 cases will be implanted 600mg sustained released 5-FU and 60mg sustained released cisplatin. Group C 50 cases will be the controlled one which will not be implanted any chemotherapeutic drugs. All patients will accepted TACE 30 days after liver resection. We will follow up all patients until they are dead or missed connected. Related adverse reaction will be recorded. Total survival time TST and disease free survival time DFST will be calculated too. At the end of the study we will compare the difference of adverse reaction, complication, TST and DFST between the 3 groups. According to the result we will estimate these drugs antitumor effect and safety. 