 7. The woman patients of childbearing age who must agree to take contraceptive methods e.g. intrauterine device, contraceptive pill or condom during the research and within another 6 months after it; who are not in the lactation period and examined as negative in blood serum test or urine pregnancy test within 7 days before the research; The man patients who must agree to take contraceptive methods during the research and within another 6 months after it 