 myocardial infarction documented by elevated cardiac enzymes or persistent regional wall abnormalities on assessment of LV function; angina pectoris that requires the use of anti-anginal medication; any history of documented congestive heart failure; serious cardiac arrhythmia requiring medication; severe conduction abnormality; valvular disease with documented cardiac function compromise; or uncontrolled hypertension defined as blood pressure 160100 mmHg. 