 2. Patients with radiographically measurable disease and histologically confirmed recurrent or progressive intracranial meningiomas refer to Appendix 1 who are not candidates for complete surgical resection of their tumors because the tumors are in eloquent areas of the brain near critical neural structuresor are not candidates for cranial irradiation because a they have already received radiation or b the tumor is in close proximity to the optic nerve and radiation would likely result in vision damage. 