 The investigators will seek to highlight the presence of inflammasome sensors and effectors in skin explants from HS compared to control skin. For this original physiopathological study, 10 lesional skins excised from HS patients or controls plastic surgery after they signed informed consent as required by the ethical review board CPP accepted on the 23-01-2015 will be investigated. HS disease severity will be based on staging according to Hurley staging. Six mm skin punches will be harvested from control explants and from both in situ and peri-lesional sites of HS skin explants. Skin samples will be handled either straight forwardly day 0 or after a period of tissue culture of 4 days with or wout treatments. 