 The ability to deliver drugs to infants and children safely and accurately has long been of concern to pediatricians and caregivers. Calibrated oral syringes are accurate in measuring and delivering the required dose, have minimal potential for spillage and are considered the standard drug delivery system for this population. However, infant acceptance of the syringe may not always be favorable. The objective of this study was to compare the Rx medibottle to the oral syringe when used to administer liquid medication to infants. It is a prospective, controlled trial that enrolled infants 2 years of age admitted to a community hospital in the Bronx, who were prescribed a daily dose of 2 mgkg of prednisolone syrup 15 mg5 ml for a respiratory illness. Participants were randomly assigned to receive one dose of prednisolone syrup using the Rx medibottle intervention arm or the oral syringe control arm. The infant medication acceptance scale MAS used to evaluate acceptance by the infants was developed and validated by Donna Kraus, Leslie Stohlmeyer and Patricia Hannon and published in the American Journal of Health-System Pharmacy 1999;16:1094-1101. 