 the studied subjects were to receive metformin 850 mg twice daily over a period of 6 months. Blood samples were collected at the start of the study, before receiving metformin, where baseline serum insulin fasting and 2 hr postprandial, sex hormone binding globulin SHBG , total and free testosterone, Dihydroepiandrostenedione sulphate DHEAS and Antimullerian Hormone AMH were obtained before starting metformin. Blood samples were collected at 3 and 6 months respectively of metformin treatment , to asses its effect on serum levels of the previously mentioned hormonal parameters. 