 We propose to perform a randomized controlled patient and assessor blind trial in women between the ages of 18 to 70 years with acute uncomplicated UTI to evaluate initial symptomatic treatment for 3 days with the non-steroidal anti-inflammatory drug diclofenac experimental intervention against immediate antibiotic treatment with norfloxacin for 3 days control intervention. Both interventions are followed by optional delayed antibiotic treatment with single dose fosfomycin if deemed necessary by the patients. The primary objective is to determine whether initial symptomatic treatment followed by optional delayed antibiotic treatment experimental intervention is non-inferior to immediate antibiotic treatment control intervention in terms of symptom resolution. 