 The primary objective of this study is to test the effectiveness of an online computerized cognitive behavioral therapy intervention to address psychological and behavioral needs of patients with sickle cell disease, namely depression and pain symptoms. The investigators will implement an existing computerized cognitive behavioral therapy CCBT program called Beating the Blues into routine clinical care at the University of Pittsburgh Medical Center UPMC Adult Sickle Cell Clinic to determine the effectiveness of this intervention in decreasing depression and pain versus treatment as usual. Patients with significant distressdepression andor anxiety symptomswill be randomized to either eight sessions of a CCBT program and weekly follow-up with a care manager or treatment as usual where the treating physician is notified of the patients symptoms. The investigators will evaluate patient acceptability, implementation and practicality of the online mental health intervention through patient use of the site frequency and duration of visits, qualitative interviews, and surveys. The investigators hypothesize: 1 the CCBT will be an acceptable mental health treatment for patients and easily integrated into routine clinical care; 2 patients in the treatment arm will show a greater decrease in depressionanxiety symptoms and average daily pain than patients in usual care. 