 4 interested in reducing meth use andor binge drinking 5 HIV-negative by rapid test or medical record of HIV infection 6 no current acute illnesses requiring prolonged medical care 7 no chronic illnesses that are likely to progress clinically during trial participation 8 able and willing to provide informed consent and adhere to visit schedule 9 age 18-70 years 10 baseline complete blood count CBC, total protein, albumin, glucose, alkaline phosphatase, creatinine, blood urea nitrogen BUN, and electrolytes without clinically significant abnormalities as determined by study clinician in conjunction with symptoms, physical exam, and medical history 