 This study will also investigate whether EPA may have an antipsychotic effect that is associated with an anti-dyskinetic effect. It has been suggested that an intrinsic aspect of the disease process of schizophrenia predisposes individuals with severe forms of the illness to antipsychotic-induced TD. These authors hypothesise that pathologic over-activity of mesolimbic and mesocortical dopamine neural systems may mediate persistence of psychotic symptoms despite adequate treatment, while increased TD vulnerability may be caused by overactive nigrostriatal dopamine activity from this process that is enhanced by antipsychotic drug exposure. If this is so, then it is possible that EPA could, by a common mechanism, have both an anti-dyskinetic and antipsychotic effect. This would explain the significant association that we found between reduction in dyskinesia scores and reduction in overall symptoms in our preliminary study unpublished. 