 Subjects with any of the following will be excluded:1 current or past psychosis; 2 bipolar I or II disorder; 3 first-degree relative with bipolar I disorder; 4 lifetime history of seizure disorder; 5 other chronic or serious medical illnesses; 6 lifetime history of eating disorder; 7 current pregnancy; 8 previous clinically significant adverse reaction to bupropion; 9 the need to take other psychotropic medications at the time of study entry. Patients may have had previous psychotherapy or pharmacotherapy for ADHD or other co-morbidity but cannot have been on psychotropic medication for at least one month prior to study entry; 10 active participation in substance abuse treatment or mental health treatment including outpatient, day-treatment, residential, or inpatient within 28 days prior to signing consent; 11 non-English speaking due to the difficulty in translating the additional materials given to the subjects; 12 cognitively impaired or of low intelligence;13 breastfeeding; 14 current use of other psychotropic medications including nicotine replacement therapy; 15 current opiate dependence. 