 PMS will be diagnosed prospectively using the DRSP. DRSP is a questionnaire comprised of 25 physical and emotional symptoms including impairment of physical and social activities, women will be asked to give a score of 1 to 6 for each symptom 1 not at all, 2 minimal, 3 mild, 4 moderate, 5 severe, 6 extreme. The investigators will add the symptoms scores of the first day of menses and PMS will be excluded if the score was 50. If the total score is greater than 50, the patients will record two cycles of symptoms. If more than three items have an average score of more than 3 mild during the luteal phase, the investigators will add the scores of five-day intervals during the luteal and follicular phases. PMS will be diagnosed when the luteal phase score is 30 percent greater than the follicular phase score in the 2 months. Women with PMS will be asked to take the drugs for 3 months and keep recording their symptoms and symptom scores will compared to those documented before treatment. 