 Arm B: chemoembolization with microspheres: doxorubicin maximum dose of 75 mg x vials of microspheres loaded with non-reabsorbable microspheres sulfate hydrospheres at the dose of 2 ml per vial definitive embolization. The chemotherapy agent is released over a 14-day period, with a concentration peak in the tumor at 72 hours from treatment, and tumor concentration which is 100-fold that achieved by traditional intra-arterial injection. Half life of the drug is about 10 times longer than traditional TACE, with a systemic concentration of the drug which is 100 times less than that observed with standard TACE. 