 Atopic dermatitis AD is a common inflammatory skin disorder that adversely affects most aspects of everyday life in majority of patients. It has a prevalence of up to 3-4 of adults and up to 25 among children. AD has a complex pathogenesis, characterized by: 1 immune activation with increased numbers of T-cells, dendritic cells DCs, and increased expression of inflammatory molecules 2 marked epidermal hyperplasia in chronic diseased skin, and 3 defective barrier function with increased trans-epidermal water loss TEWL and decreased lipids, reflecting underlying alterations in keratinocyte differentiation. AD is predominantly a Th2 IL-4, IL-13, and IL-31 disease, and recently was also found to be a T22 IL-22 polarized disease. 