 13. Systemic treatment, within 14 days before the first dose of ixazomib, with strong inhibitors of CYP1A2 fluvoxamine, enoxacin, ciprofloxacin, strong inhibitors of CYP3A clarithromycin, telithromycin, itraconazole, voriconazole, ketoconazole, nefazodone, posaconazole or strong CYP3A inducers rifampin, rifapentine, rifabutin, carbamazepine, phenytoin, phenobarbital, or use of Ginkgo biloba or St. Johns wort. 