 Male and female subjects, FHP biological father and one other first degree relative between the ages of 21-30, and matched controls FHN will complete 2 test days in a randomized balanced order under double-blind conditions. Test days will involve the 60-minute intravenous infusion of placebo and ketamine. Outcome measures include the Biphasic Alcohol Scale and visual analog scales for mood states. Secondary measures include visual analog scales for high, similarity to ethanol, the Sensation Scale a validated measure of ethanol-like sensations and aspects of craving for alcohol. 