 Several aetiologies have been identified or are under discussion to play a role in RPL, including chromosomal translocations and inversions, anatomic alterations of the uterus, endocrinological abnormalities, autoimmune disorders infection, smoking and alcohol consumption, exposure to environmental factors as well as coagulation and immunoregulatory defects Pandey 2005, Lee 2000. About 30-40 of cases of RPL remain unexplained after standard gynaecological, hormonal and karyotype analysis Rey 2000. 