 Adequate renal function: Serum creatinine 1.5 x ULN, or 50 mlmin. Adequate liver function :Total bilirubin 1.5 x upper limit of normal ULN and Alanine Aminotransferase ALT and Aspartate Aminotransferase AST 2.5 x ULN in the absence of liver metastases, or 5 x ULN in case of liver metastases. 