 ii. If after phenobarbital treatment has been started, at least 2 NAS scores 8 or 1 NAS score 12, then a phenobarbital level will be drawn and a mini-load calculated to reach a level of 30 mgdl. If withdrawal is not controlled or re-emerges after the mini-load dose, the infant will be randomized to one of the two arms of the study - methadone or dDTO. 