 5. Target Population: h. All baseline laboratory requirements will be assessed and should be obtained within -14 days of study registration. Screening laboratory values must meet the following criteria: i WBCs 2000uL; ii Neutrophils 1500uL; iii Platelets 100 x 103uL; iv Hemoglobin 9.0 gdL; v Serum creatinine of 1.5 X ULN or creatinine clearance 40 mLminute using CockcroftGault formula. Female CrCl 140- age in years x weight in kg x 0.85 72 x serum creatinine in mg dL. Male CrCl 140- age in years x weight in kg x 1.00 72 x serum creatinine in mg dL; vi AST 1.5X ULN; vii ALT 1.5X ULN; viii Total bilirubin ULN except subjects with Gilbert Syndrome who must have total bilirubin 3.0 mgdl. 