 - All subjects are with prediabetes IFG or IGT or newly diagnosed type 2 DM T2DM no taking medicine. IFG was defined as fasting glucose between 100 and 125 mgdL and IGT was defined as 2-h OGTTs glucose levels 140-199 mgdL. Newly diagnosed type 2 diabetes was defined as fasting glucose 126 mgdL or 2-h OGTTs level 200 mgdL. 