 - Exclusion Criteria All patients should not have hepatocellular carcinoma or other malignant tumors, they should not be treated with anticoagulant antiplatelet agents, not affected by PVT already diagnosed and not suffering from congenital coagulation disorders haemophilia A B, von disease Willebrand, another congenital deficiency of coagulation factors or severe thrombocytopenia 30,000μl. 