 To date, the majority of prandial insulin dosing algorithms for subjects with T1DM considers only the carbohydrate CHO content of the meal. However, there is evidence although with a certain degree of heterogeneity that meal composition significantly affects postprandial glucose control, contributing to glycemic variability. Moreover, despite the high prevalence of alcohol consumption among patients with T1DM about 30, similar to that of the general population, data regarding its effect on the postprandial period are very limited. 