 Patients undergo blood sample collection at baseline and periodically during course 1 for panobinostat pharmacokinetic studies. Patients enrolled in the dose expansion cohort also undergo collection of tumor tissue samples by fine needle aspiration at baseline and on day 5 of course 1 after panobinostat infusion. Blood and tissue samples are analyzed for histone acetylation, chromatin remodeling genes and proteins HP-1, DNMT-1, SMC1-5, Topo II, and HDAC enzyme expression by immunofluorescence and western blotting. 