 - Any corticosteroids, anti-inflammatory drugs, immunomodulators or anticoagulants. Any participant currently receiving or having previously received immunosuppressive therapy, including systemic steroids including adrenocorticotrophic hormone ACTH or inhaled steroids in dosages which are associated with hypothalamic-pituitary-adrenal axis suppression such as 1 mgkgday of prednisone or its equivalent or chronic use of inhaled high potency corticosteroids budesonide 800 μg per day or fluticasone 750 μg. 