 Patients enrolled in this trial at the St Jamess Hospital site, will be invited to consent to having some of their tissue and blood taken for use in future research studies. Following consent from the patient, tissue biopsy of tumour andor normal oesophageal tissue will be obtained for research at the same time as that biopsied for histological diagnosis. In addition, tumour andor normal tissue will also be obtained following surgical resection. Patient blood samples will also be obtained, both before and during treatment. The identification of both tumour and circulating biomarkers will increase knowledge of the molecular mechanisms underlying treatment response in oesophageal cancer and may facilitate the identification of biomarkers predicting patient response to treatment. 