 - Be a healthy male or female 18 to 45 years of age. Women were required to be postmenopausal more than 12 months since last period; surgically sterile hysterectomy or tubal ligation at least 6 months prior to enrollment; using an intrauterine device; or double barrier i.e. diaphragm or spermicide plus male condom non-hormonal contraceptive therapy for the duration of the trial and were required to have a negative pregnancy test at screening and upon each check-in to the study facility. 