 Except for the important of platelets in occlusive vascular events several studies suggests that they may also have a role in the evolutionary phase of the atherosclerotic plaque. After adhesion to exposed subendothelium following endothelial injury they release vasoactive substances that induce smooth muscle cell migration and proliferation. Platelets may serve as a lipid source in the development of the fatty streak and can promote foam cell formation even in the absence of hyperlipidemia. However, currently there is no clear clinical evidence that platelets contribute to coronary atherosclerosis. In addition, prophylactic therapy with aspirin has not been clearly shown to decrease the atherosclerotic burden. 