 - Patients with untreated brain metastases are excluded; however, patients with metastatic central nervous system CNS tumors may participate in this trial, if the patient is 2 weeks from therapy completion incl. radiation andor surgery, is clinically stable at the time of study entry; stable corticosteroids treatment e.g. dexamethasone 2 mgday, prednisolone 10 mgday is permitted if it was initiated at least 14 days before start of study treatment 