 We propose a prospective study to investigate the combinational effect of radiotherapeutic dosimetric parameters mean lung dose and percentage of lung volume receiving at least XGy Vx and biological parameters interleukin-1αIL1α,interleukin-1βIL1β,interleukin-6IL6,interleukin-7IL7,transforming growth factor beta TGFB and manganese superoxide dismutaseMnSOD in predicting radiation pneumonitis, fibrosis, and radiation esophageal injury. Eligibility included pathological or cytological proven thoracic cancer,ECOG performance status PS 0-2, no prior thoracic RT or chemotherapy,no distant metastasis and signed informed consent prior to study entry. 