 All patients trios both parents patient with IIS trio with IIS retrospectively identified to have been treated with ACTH according to FDA-approved protocol will be eligible for inclusion in this study regardless of age, sex, ethnicityrace, or socioeconomic status. The principal recruitment venues will be Neurology clinics, in-patient service and Medical Genetics Clinics at Childrens Hospital Colorado and University of Colorado Health Sciences Center UCHSC 