 Preliminary investigations done by McDaniel et al. demonstrated that fibroblast activity could be regulated using pulsing light at specific wavelenghts. Using a variety of LED light sources, his group has demonstrated that by varying light pulses and other parameters, procollagen synthesis could be upregulated in human skin fibroblast culture McDaniel DH, et al.Lasers Surg Med. 2002; 14-251. A clinical correlation was also shown based on different clinical trials data on around 1000 subjects, LED has shown up to 90 improvement in wrinkles and an increase of collagen synthesis versus control with little or no side effects associated Weiss, RA et al. Lasers Surg Med 2005; 362: 85-91- Weiss, RA et al.: J Drugs Dermatol 2004; 36: 605-610 - Weiss RA et al. Dermatol Surg 2005; 319:1999-1204 - Russel BA et al. J Cosmet Laser Ther 2005; 7 3-4:196-200 - Bhat J et al. Laser Med Sci 2005; 201:6-10. Based on these promising clinical data, Light BioScience submitted a dossier to the Food and Drug Administration FDA and obtained in January 2005 the FDA approval for its GentleWaves Light Emitting Diode LED for the non-invasive treatment of periorbital eye area wrinkles and rhytids. The LED technology has been considered by FDA as non significant risk. In Europe, the GentleWaves Light Emitting Diode has obtained the notified body certification for the same indication. This medical claim is associated with cosmetic improvement of aging and sun-damaged skin, further validation the science of LED photomodulation skin rejuvenation Investigators Brochure. Version 1. 