 - A female subject is eligible to participate if she is of: Non-childbearing potential defined as pre-menopausal females with a documented tubal ligation or hysterectomy for this definition, documented refers to the outcome of the investigatorsdesignees review of the subjects medical history for study eligibility, as obtained via a verbal interview with the subject or from the subjects medical records; or postmenopausal defined as 12 months of spontaneous amenorrhea in questionable cases a blood sample with simultaneous follicle stimulating hormone FSH 40 milli international unit per milliliter MlUmL and estradiol 40 picogram pgmL 147 picomol per liter pmolL is confirmatory; child-bearing potential with negative pregnancy test as determined by urine human chorionic gonadotropin hCG test at screening or prior to dosing and agrees to use one of the contraception methods for an appropriate period of time as determined by the product label or investigator prior to the start of dosing to sufficiently minimize the risk of pregnancy at that point. Female subjects must agree to use contraception until 1 week post-last dose. 