 Data Analysis: All data will be entered into a custom-developed secure anonymized database. Data analyses will be performed using StataCorp. 2009. Stata Statistical Software: Release 11 College Station, TX: StataCorp LP. Continuous data will be reported as means and standard deviations SD or median and interquartile ranges IQR. Chi-square testing will be used for bi-variable analyses of dichotomous variables; continuous variables will be compared using t-tests or Mann-Whitney tests. Two-tailed results p 0.05 will be considered statistically significant. The influence of patient characteristics and treatment factors on the dependent variables i.e. inflammation, vascular function, self efficacy and LOS will analyzed through a multiple linear or logistic regression models as appropriate. For the linear regression model, clinically relevant and statistically significant at the p 0.1 level independent variables will be included. For the logistic regression model, several dependent variables will be explored; clinically relevant and statistically significant at the p 0.1 level independent variables will be included. 