 - HFpEF, defined as signs and symptoms of heart failure, LV ejection fraction 50, brain natriuretic peptide 35pgmL and echocardiographic evidence of diastolic dysfunction left atrial volume index 34mLm2, mitral E-wave velocitymitral annular velocity ratio Ee13 and e9cms plus 2 of the following 4 comorbidities: 