 The primary outcome is the adecuacy of tissue perfusion at six hours urinary output, blood pressure, lactate clearance, skin aspect. The secondary oucomes are duration of cardiovascular failure at the end of the 6 hours resuscitation period number of days, duration of respiratory failure need of mechanical ventilation, number of days, duration of acute renal failure need of dialysis at ICU discharge103060 days, duration of ICU stay and in hospital stay, discharge status at 60 days not discharged ,discharge to another acute care hospital, discharged to nursing home, discharged home ,other or unknown and all cause mortality at 60 days. 