 Maximal loss of bone following transplantation is seen by 3 months. Earlier data on bone loss in liver transplant patients from the RPAH unit demonstrated an average of 24 bone loss by 3 months post-transplantation. Prevention of this effect should provide a precise and early measurement of the effect of zoledronate on transplant-related bone loss. Bone density of the hip, spine, and total body will be measured by dual xray absorptiometry DEXA at baseline not more than 6 months prior to liver transplantation, and 3, 6 and 12 months following liver transplantation. 