 - Known thrombophilia except for those listed above, with a history of adverse pregnancy outcome APO as defined by: Ý3 pregnancy losses in the 1st trimester, Ý2 pregnancy lossesstillbirth in 2nd trimester, Ý1 pregnancy lossintrauterine fetal demise IUFD in the 3rd trimester, intrauterine growth restriction IUGR, abruptio placentae, or severe pre-Eclampsia prior to 34 weeks gestation. 