 - Symptomatic knee osteoarthritis of a unilateral knee, characterized by pain at walking WOMAC A1 score assessed over the previous 24 hours on a 100-mm Visual Analog Scale VAS: 50 WOMAC A1 90 or reduced joint function total WOMAC C score assessed or over the previous 24 hours on a 100-mm VAS: 50 WOMAC A1 90 