 The treatment management of single BM remains controversial. Indeed, even though it is widely accepted that local treatment increases the median survival time in patients having a good prognostic status, the adding of adjuvant whole-brain radiation therapy WBRT is currently subject to controversy, due to its potential toxicity. Yet, two randomized trials have demonstrated a clear increase in intra-cerebral recurrence and in death from neurologic origin in case of absence of adjuvant WBRT, without change in overall survival but overall survival was not a primary endpoint in any of these studies. 