 - Patients will be excluded from the study if any one of the following criteria is present: 1 children and teenagers aged less than 20 years, 2 history of gastrectomy, 3gastric malignancy, including adenocarcinoma and lymphoma, 4 previous allergic reaction to antibiotics Amoxicillin, Klaricid, Cravit and prompt pump inhibitors esomeprazole, 5contraindication to treatment drugs, 6 pregnant or lactating women, 7 severe concurrent disease. 