 Most patients who have surgery for cancer that has metastasized spread to the lungs later get more metastases that cannot be treated with surgery or chemotherapy. The drug resistance may be due to DNA changes in cancer cells that activate some genes and turn others off. Researchers want to test a combination of drugs for people with metasteses. Decitabine DAC may reverse the DNA changes. Tetrahydrouridine THU makes DAC last longer. Celecoxib may slow the progression of cancer. 