 And the study will include all pediatric patients diagnosed to have HD and will be subjected to definitive pullthrough procedure. Each of these sites contains a quaternary level of pediatric surgical care, and treats a large number of patients with HD on a yearly basis. The key advantage of Tanta University is that this Hospital group treats three-fold more HD patients on a yearly basis than the other Sites, and has a very highly motivated staff with research interests in HAEC. 