 - Pathologically confirmed WHO grade IV glioblastoma or variants gliosarcoma, glioblastoma with oligodendroglial features, giant cell glioblastoma with adequate tumor material for genomic sequencing as confirmed by study pathologist Keith Ligon, MD, PhD or his designate. Participants will be eligible if the original diagnosis was a lower grade glioma and a subsequent histologic diagnosis of glioblastoma or its variants was made, and they received no prior therapy other than surgery 