 The investigators group has also investigated the presence of increased LV trabeculation in a population of sickle cell anaemia patients. Chronic anaemia of sickle cell disease is associated with an increased LV preload and high cardiac output. The investigators found increased LV trabeculation in 28 of sickle cell anaemia patients as compared with 12 of asymptomatic healthy black controls. 8 of sickle cell anaemia patients fulfilled both Chin and Jenni criteria for LVNC. 