 The group B Streptococcus GBS or Streptococcus agalactiae is a gram-positive bacterium that is present in 10-30 of the healthy female population 1. Throughout pregnancy and the intrapartum period, maternal colonization with GBS can lead to the vertical transmission of the bacterium to the infant. This can result in neonatal sepsis, pneumonia, and meningitis, known as early-onset GBS infection, as well as in maternal urinary tract infections, arthritis, and pneumonia 2. Various strategies were tested to prevent the GBS infection. The antenatal GBS screening was successfully proven to identify colonized women, who should receive the intrapartum antimicrobial prophylaxis. This strategy led to a substantial reduction of the incidence of neonatal sepsis of almost 80 3. As a result, the general use of a GBS screening was then integrated in the US-American recommendations, since the screening was superior to the risk-related procedure, when comparing the rates of early-onset neonatal sepsis 4. Later on, the GBS screening also became part of the recommendations of a European Consensus Conference 3. 