 - Adequate bone marrow, renal and hepatic function as defined by: absolute neutrophil count 1.5 x 109L, hemoglobin 9 gL, platelets 100 x 109L, calculated creatinine clearance 55 mlmin, total bilirubin 1.5 x the upper limit of normal, alanine aminotransferase ALT 2.5 upper limit of normal. 