 - Use of prescription or non-prescription drugs, including vitamins above the recommended daily intake herbal and dietary supplements within 7 days or 5 half-lives whichever is longer prior to the first dose of study medication, or use of St. Johns Wort within 14 days prior to the first dose of study medication. By exception, the volunteer may take acetaminophen or equal to 2 gramsday or ibuprofen 1600 mgday up to 48 hours prior to the first dose of study medication. However, the investigator and study team can review medication use on a case by case basis to determine if its use would compromise subject safety or interfere with study procedures or data interpretation. 