 A. Ambisome at a dose of 3-5 mgkgday or other appropriate antifungal based upon standard of care will be administered intravenously B. Antifungal lock therapy with Ambisome will be administered. It consists of the placing up to 2.3 ml based upon specific catheter types and volumes of concentrated Ambisome into the infected CVC and allowing it to dwell uninterruptedly for 8 to 12 hours per day. The concentration of Ambisome is 2 mgml in sterile water 4. 