 - Adequate organ function defined as: absolute neutrophil count ANC 1,500mm3, platelets 100,000mm3, creatinine clearance 50mLmin, alanine aminotransferase ALT and aspartate aminotransferase AST 2.5 x upper limit of normal ULN; or 5 x ULN in case of liver metastases; total bilirubin 1.5 mgdL 