 - Subject requires use of prohibited previous and concomitant medication i.e., thrombolytics such as tissue Plasminogen Activator tPA, streptokinase, antiplatelet agents such as cilostazol, clopidogrel, ticlopidine, dipyridamole, anticoagulants such as vitamin K antagonists, heparin, unfractionated or low molecular weight heparin, fondaparinux, thrombin inhibitors and chronic use of nonsteroidal anti-inflammatory drugs NSAIDs or acetylsalicylic acid use of 100 mgday. see Section 5.1.3 and Appendix 1 for details 