 4. Presence of any concurrent medical condition that would increase the risk of toxicity, including the following: Pleural or pericardial effusion of any grade Uncontrolled angina Congestive heart failure Myocardial infarction within the past 6 months Diagnosed congenital long QT syndrome Any history of clinical significant ventricular arrhythmias such as ventricular tachycardia, ventricular fibrillation, or Torsades de pointes Prolonged QTc interval 450 ms on pre-study ECG Uncorrectable hypokalemia or hypomagnesia Significant bleeding disorder unrelated to cancer, including: - History of congenital bleeding disorders e.g. von Willebrands disease - Acquired bleeding disorder that has been diagnosed within the past year e.g. acquired anti-factor VIII antibodies - Ongoing or recent less than or equal to 3 months significant gastrointestinal bleeding. 