 The effect size used is the average across men and women. The study is not powered to assess the separate effect on each gender, but sub-analyses estimating the effect of gender as a covariate can be done. Potential confounders and effect modifiers will be tested in multiple linear and logistic regression models depending on the distribution of the outcome variable. The longitudinal data across our four proposed time points will be analyzed using a general linear model, repeated measures technique, in order to understand the effect of variations due to groups i.e., a between-groups effect and due to follow-up time i.e., a within-groups effect. An interaction term between groups and follow-up time will also be fitted. Missing data will be handled through multiple imputation techniques as necessary. 