 A. Anisometropia spherical equivalent must be within 0.25 D of the full anisometropic difference B. Astigmatism cylinder must be within 0.25 D of full correction and axis must be within 5 degree C. For hyperopia and myopia, the spherical component can be reduced by investigator discretion provided reduction is symmetrical and results in residual i.e., uncorrected spherical equivalent refractive error that does not exceed 1.50 D spherical equivalent hyperopia or -0.50 D spherical equivalent myopia 