 The goal of this study is to enroll 1000 participants with a history of Multiple Sclerosis into the MURDOCK Study Duke IRB Pro00011196 as well as into the Multiple Sclerosis Cohort study Duke IRB Pro00023791. All 1000 participants will answer a 4-page questionnaire administered by a trained study coordinator which is designed to collect information on the participants diagnosis of Multiple Sclerosis. The goal of the study is to seek genetic explanations for response to treatment, progression of the disease, and biomarker validation. 