 Absolute neutrophil count 1,500 cellsmm3 Platelet count 100,000 cellsmm3 Haemoglobin 9 gdL Inadequate hepatic function Inadequate renal function Prothrombin time international normalized rationpartial thromboplastin time 1.5 times the ULN Serum sodium, potassium, calcium and magnesium levels equivalent to Grade 1 AE values as defined by Common Terminology Criteria for Adverse Events version 4.0 