 Methods Pragmatic randomised controlled trial, involving United Kingdom UK osteopaths in private practice and NHS health visitors. Parents of 60 excessively crying infantsinfants with colic will be recruited by NHS health visitors. Infants will be included into the study if they are healthy full-term and aged 1-7 weeks, diagnosed with excessive cryinginfantile colic, and have no co-morbidities. Participants will be randomised into the usual NHS care group or the usual NHS care plus cranial osteopathic intervention group. 