 Hepatocellular Carcinoma patients may be enrolled based on radiological diagnosis instead of histological or cytological diagnosis - based on EASL-EORTC Clinical Practice Guidelines: Management of hepatocellular carcinoma Journal of Hepatology 56:908-943, 2012, non-invasive hepatocellular carcinoma patients should not be put under additional undue risk of liver biopsy after the diagnosis of hepatocellular carcinoma has been ascertained with clinical, laboratory and radiographic evaluation. 