 The efficacy of anti-depressants or lithium reported in clinical trials differs from clinical experience. Various factors such as non-adherence to treatment and poor tolerability to medications have been related to treatment non-response or treatment failure in mood disorders major depressive disorder and bipolar disorder. Premature discontinuation of treatment for mood disorders is common. The long treatments, the patients beliefs about medications, the lack of knowledge about the medicationtreatment purpose, benefits, dosage, and side effects and the relationship between patient and healthcare providers affect treatment continuation. 