 At a Screening Visit Visit 1, performed within 4 weeks prior to Baseline, subjects who provide written informed consent will have screening procedures performed, including complete medical, ophthalmologic, and medication histories; physical examination; vital signs and weight; electrocardiogram ECG; ophthalmologic examination; tonometry; visual field VF assessment; corneal pachymetry; evaluation of inclusion and exclusion criteria; safety laboratory tests; serum pregnancy test for all females of child-bearing potential; and collection of concomitant medication information. 