 The electronic data capture EDC system will be used for communications between the enrollmentdata center, Yamato Logistics and participating medical institution. Information on subjects will be reported by e-mail to the data center, and the data center will ensure the information by telephone to Yamato Logistics and the investigational drug management division of the medical institution. The test drugs will be delivered by Yamato Logistics to the medical institution. The test drugs for only a subject will be delivered once allocation adjustment factor. Considering that a number of days are necessary for delivery, there should be at least 3 working days between enrollment and start of treatment. The interval between enrollment and start of treatments should be up to 14 days. Physicians treating subjects are not allowed to manage the test drugs. The vice manager will manage the test drugs according to subjects under the supervision of the manager. Orders for the test drugs will be made by letter or e-mail in accordance with the medical institutions procedures. A sufficient number of capsules of the test drugs until the next hospital visit will be orderedprescribed once. If the test drugs are used properly in accordance with the protocol, an orderprescription for the test drugs will be made every 7 days. Subjects patients will be advised to keep records of the use of regorafenib and test drugs in the medication diary. The remaining number of capsules of the test drugs will be checked in consideration of the use of the test drugs. The remaining test drugs will be returned to the study office. In accordance with the protocol, the test drugs should be prescribed for 28-day treatment, but will be prescribed for 30-day treatment considering loss and damage. The test drug for 2-day treatment should be left unused when treatment is completed. The remaining test drugs will be returned to the enrollmentdata center. 