 Alarm-treatment as well as Desmopressin, a synthetic analogue of human vasopressin, are considered the only evidence-based medicine EBM IA treatments in monosymptomatic nocturnal enuresis MNE. Desmopressin exists in three different formulations for ambulant use: nasal spray, tablet and lyophilisate MELT each with differences in bioavailability spray 2, tablet 0.2, MELT 0.5. There s insufficient evidence to confirm the actually used bioequivalent doses 10μg spray 120μg MELT 0.2mg tablet. 