 7. Major surgery e.g., intra-thoracic, intra-abdominal or intra-pelvic within 4 weeks prior 2 weeks for resection of brain metastases to starting LDK378 treatment or who have not recovered from side effects of such procedures. Video-assisted thoracic surgery VATS and mediastinoscopy will not be counted as major surgery, and patients can be enrolled in the ETP 2 weeks after the procedure. 