 - At the start of the Screeningprospective observational Phase, participant must meet the Diagnostic and Statistical Manual of Mental Disorders DSM-5 diagnostic criteria for single-episode major depressive disorder MDD if single-episode MDD, the duration must be greater than or equal to 2 years or recurrent MDD, without psychotic features, based upon clinical assessment and confirmed by the Mini-International Neuropsychiatric Interview MINI 