 Symptoms of renal Fanconi disease usually become apparent between 6 and 12 months of age and may include excessive thirst polydipsia, excessive production and passage of urine polyuria, electrolyte imbalances, vomiting, and dehydration with or without fever. Dehydration can be severe in some cases. Children with nephropathic cystinosis may also develop symptoms unrelated to the kidneys extrarenal symptoms. Again, these findings are highly variable and affected children will not develop all of the symptoms discussed below. Specific extrarenal symptoms will vary greatly depending upon the age that treatment is begun and the specific organs that become involved; those organs can include the eyes, bone marrow, liver, pancreas, spleen, intestine, brain, thyroid, muscles and testes. 