 - Concomitant use of strong inhibitors of both cytochrome P450 isoenzyme 3A4 CYP3A4 and P-glycoprotein P-gp, e.g. all human immunodeficiency virus protease inhibitors and the following azole-antimycotics agents: ketoconazole, itraconazole, voriconazole, posaconazole, if used systemically fluconazole is allowed 