 There were 2 phases in the study, a Dose Escalation phase Phase 1b and a Dose Expansion phase Phase 2a. In the Dose Escalation phase, 3 patients were enrolled at the first dose level 3.0 mgkg trastuzumab emtansine and and 6 patients were enrolled at the second dose level 3.6 mgkg trastuzumab emtansine. An additional 58 patients were enrolled at the 3.6 mgkg trastuzumab emtansine dose level in the Dose Expansion phase Phase 2a of the study. 