 - 1patients to be diaginsed according to DSM-IV for substance abused,development delayed;2suffering from serious physical disease and can not accept the treatment;3rTMS contraindications: intracranial metal substance, with heart pacemakers and cochlear implants, intracranial pressure;4the disease situation is not stable, the fluctuation of PANSS total score 10 in last 1 month, PANSS total score 60;5difficult to maintain the current drug treatment for at least 1 month;6undergoing ECT or MECT in last 3 months. 