 In southern Africa, TB is the most common first AIDS-defining condition. Initiating Antiretroviral therapy ART in HIV positive TB patients will lead to the inclusion of the majority of HIVAIDS patients currently fulfilling the criteria for therapy. Establishing an effective intervention to increase treatment adherence in this group is essential for the successful roll out of ART in the region. This proposed randomized controlled study aims to compare the effectiveness of two adherence support programmes ASP for use in patients with HIV-related TB in the context of CAPRISA AIDS Treatment CATprogramme in KwaZulu-Natal, South Africa; the enhanced adherence support programme E-ASP or the standard adherence support programme S-ASP. 