 Peripheral T-cell lymphoma PTCL represents a heterogeneous group of nodal and extranodal mature T-cell lymphomas, which constitute about 5 - 10 of all non-Hodgkin lymphomas NHLs in Western countries compared to 20 - 30 of all lymphomas in the East Asia. The most common histologies include PTCL, not otherwise specified PTCL-NOS, angioimmunoblastic T-cell lymphoma AITL, and anaplastic large cell lymphoma ALCL 3. Most of these subtypes include a high percentage of patients with advanced disease stage, widespread dissemination and aggressive behavior. As a result, the prognosis of PTCL remains dismal, with the 5-year overall survival OS rate for many of these subtypes ranging between 25 and 45, except for ALCL ALK , which demonstrates a better 5-year OS 70 4 - 6. Thus, new therapeutic strategies are needed to improve the survival of patients with PTCL. 