 - Participants who do not have the cognitive competence and legal capacity to make informed medical decisions are excluded at entry. If a participant experiences significant cognitive decline during the study such that they no longer have medical decision making capacity the investigators will enact procedures that have been approved locally by the IRB and legal counsel at the University of Wisconsin-Madison: A use their initial expressed and written consent as an indicator of willingness to continue to participate in the study; AND B require that they provide assent at the time of follow-up visits witnessed and counter signed by their caregiver; AND C signed consent from the patients legally authorized representative. 