 The purpose of this study is to compare the additional use of gloves with handwashing before and after gloving for all patient contact while infants have intravenous central or peripheral access in a RCT. Preterm infants 1000 grams or less than 29 weeks gestational age will be randomized after birth to either a handwashing-gloving group or handwashing only group. The primary outcome will be the incidence of invasive infections bacterial or fungal or necrotizing enterocolitis. Secondary outcomes will include hospital days, preterm morbidities, mortality, and hospital costs. 