 16. Clinically significant ECG abnormalities, e.g.: QRS duration 0.12 seconds; QTc 450 ms in males or 460 ms in females;High-grade trioventricular AV block; Left bundle branch blockLBBB; Left ventricular hypertrophyLVH with secondary ST-T changes; Frequent, recurrent, or sustained ventricular arrhythmia; Resting ST segment depression 1 mm measured 80 ms beyond the J point at baseline. 