 - Systemic treatment, within 14 days before the first dose of ixazomib, with strong inhibitors of cytochrome P450 family 3, subfamily A, polypeptide 2 CYP1A2 fluvoxamine, enoxacin, ciprofloxacin, strong inhibitors of cytochrome P450 family 3, subfamily A CYP3A clarithromycin, telithromycin, itraconazole, voriconazole, ketoconazole, nefazodone, posaconazole or strong CYP3A inducers rifampin, rifapentine, rifabutin, carbamazepine, phenytoin, phenobarbital, or use of Ginkgo biloba or St. Johns wort 