 2. Cardiac: involvement is defined as the presence of a mean left ventricular wall thickness on echocardiogram more than 12 mm in the absence of a history of hypertension or valvular heart disease, or unexplained low voltage 0.5 mV on electrocardiogram; or an NT-proBNP 332 ngL in CKD 1 or 2 patients or a BNP 100ngL in those who are CKD3. 