 At the end of Cycle 2, you will have a bone marrow biopsy andor aspirate to check the status of the disease. This will then be repeated every 2-4 cycles until any point that the disease appears to have responded to the study drug, then as often as the study doctor thinks is necessary. To collect a bone marrow biopsyaspirate, an area of the hip bone is numbed with anesthetic, and a small amount of bone andor bone marrow is withdrawn through a large needle. 