 The aim of this study is to assess the efficacy of Nepeta menthoides as an anti anxiety herbal remedy for depressed patients , in a 6 week randomized double-blind controlled trial. A total of 70 adult outpatients between 18-65 ages referring to psychiatry clinic of Shiraz medical university, who having depression according to Persianlanguage version of the Beck Depression InventorySecond edition and get score above 11 according to Persian version of Beck Anxiety Inventory BAI and diagnosis is confirmed by at two psychiatrists are randomly allocated into two groups and assign to receive 400 mg of freeze dried powder of Nepeta menthoides or 50 mg of sertraline in the uniformed capsules twice daily in the morning and 1-2 hours before sleeping time at night. Exclusion criteria were pregnancy and lactation, allergy to N. menthoides and Lamiaceae family, patients with suicidal thoughts or previous suicidal attempt, patients with unstable cardiac, renal and hepatic diseases, seizure and hypothyroidism and patients who used substances or alcohol and patients who had indication for electroconvulsive therapy.. Severity of anxiety by Persian version of Beck Anxiety Inventory BAI and also common possible side effects of drugs will assess in baseline, 2nd week, 4th week and then two weeks after the end of the intervention in 6th week 