 To avoid blood transfusion after THA, tranexamic acid TXA can be administered. TXA, a synthetic amino acid that blocks the lysine binding sites on plasminogen in a competitive way, is an antifibrinolytic agent. TXA can be administered intravenously or intra-articular. The ideal method of providing TXA remains topic of debate. Several studies have proven that intravenous application reduces blood loss and the need for blood transfusion in patients undergoing THA . In contrast, after intravenous administration only a small percentage of the drug reaches the target location, the rest distributes across the whole body. Hence the risk of possible side effects after intravenous administration, like thromboembolic events and gastrointestinal complaints, theoretically is greater. 