 - Use of any prescription or over the counter OTC medications, or herbal remedies such as St Johns wort, known to be strong inhibitors or strong inducers of cytochrome CYP enzymes also known as CYP P450 enzymes during the 30 days before the first dose of study medication; use of any other prescription or OTC medicine with the exception of acetaminophen paracetamol, including dietary supplements or herbal remedies, during the 7 days before the dose of study medication. 