 Non-melanoma skin cancers NMSCs, which include basal cell carcinomas BCCs and cutaneous squamous carcinomas SCCs, are the most common malignancy in the U.S.; it is estimated that 3.5 million new NMSCs this year. This represents a tremendous economic impact on the U.S. healthcare system. Most NMSC are caused by overexposure to ultraviolet radiation, and current methods for their prevention consist of recommendations for limitations to sun exposure and avoidance of indoor tanning beds, the regular application of sunscreens, and a variety of other photoprotective activities. Despite these measures, the incidence of NMSCs continues to rise. 