 The secondary objective is to estimate the effect of coordinated intervention of cancer network, within the first 6 months after oral neoplastic agent introduction, in terms of number of hospitalization for AE, number of consultation for AE, number of early or unforeseen recourses to hospital for grade 1 2 AE, number of AE per detection grade, AE maximal grade, AE all grade, disease progression, the global survival death for any causes and for AE, drug dose-intensity taken by the patient during his treatment, number of recourses to the health care system, quality of life, patients satisfaction, medical economic evaluation 