 7. Subjects must have at least one evaluable myeloma marker by which to judge response: serum M protein 1gdL, free light chains in the serum that more than four times the upper limit of normal, urine M protein of 500 mg, urine free light chains of 500 mgday, bone marrow plasmacytosis with 20 plasma cells, extramedullary plasmacytosis, or MRIFDG-PETCT scan demonstrating 1 or more focal lesions due to myeloma. 