 -Physical Examination: The study physician will conduct a brief physical examination and clinical history to assess for signs or symptoms of STIs, including urethritis, proctitis, and genital ulcer disease. During the physical examination, the study physician will obtain swabs of the rectum and oropharynx. While performing the pharyngeal exam, the physician will use a new Aptima GenProbe collection kit to obtain a swab of the tonsillar pillars. While performing the rectal examination, the physician will use a new Aptima GenProbe collection kit to obtain a swab of the anorectal canal. Participants will also be given the option to self-collect the rectal swab specimen. No urethral swab will be obtained for this study. 