 5. History of cardiac disease congestive heart failure New York Heart Association NYHA class 2; active coronary artery disease myocardial infarction more than 6 months prior to study entry is permitted; cardiac arrhythmias requiring anti-arrhythmic therapy other than beta blockers, calcium channel blocker or digoxin; uncontrolled hypertension failure of diastolic blood pressure to fall below 90 mmHg, despite the use of 3 antihypertensive drugs. 