 Regardless of the progressive form and the existence of outbreaks, the fatigue symptom is one of the most frequent and disabling one in patients with MS. The proposed pathogenic mechanisms are multiple, although its exact pathophysiology is unknown. Also, there is still no treatment that has proven to be completely effective in stopping the progression of the disease 5. Description of the botanical drug to be used in this clinical research: The botanical drug to be used in this clinical research, is a phytopharmaceutical tablet made by Good Manufacturing Practices GMP containing a purified, standardized and patented extract of Andrographis paniculata Nees Acanthaceae U.S. Patent: 8,084,495 B2; Date: Dec. 27, 2011 ApE. 