 - Current use of a prohibited medication; patients receiving any medications or substances that are strong inhibitors or inducers of cytochrome P450, family 3, subfamily A CYP3A or cytochrome P450, family 2, subfamily C, polypeptide 8 CYP2C8 are ineligible; current use of, or intended ongoing treatment with: herbal remedies e.g., St. Johns wort, or strong inhibitors or inducers of P-glycoprotein Pgp or breast cancer resistance protein 1 Bcrp1 should also be excluded 