 All lesions detected will be documented and biopsied for a maximum of four biopsies per suspicious lesion. Note will be taken of which modality resulted in visualization of the lesion. Data on the factors under study will be collected: i disease type CUC PSC or CUC with known dysplasia, ii Age, iii Sex, iv length of time with disease, v extent of disease, vi the interaction between iv and v will be collected. In addition, dysplasia yesno will be established after biopsy histology is established and the modality under which abnormalities were observed will also be recorded. 