 Magnetization transfer imaging MTI is a widely used tool for characterizing the evolution of multiple sclerosis MS lesions and normal appearing brain tissue NABT. As remyelination and demyelination are heterogeneous in each lesion and NABT, techniques such as voxel-wise based MTR dynamic mapping may help predict an individuals clinical course, as well as the effect of treatment, by revealing evidence of myelin repair and neuroprotection. 