 Moxifloxacin is a fluoroquinolone that has potent activity against M. tuberculosis. Moxifloxacin is well absorbed and has 90 bioavailability. The PK parameters are linear from 50 to 800 mg single dose and 600 mg once daily dosing over 10 days. Steady state is reached within 3 days. The mean SD Cmax and AUC0-24 values at steady state with a 400-mg once-daily dosage regimen are 4.5 0.5 μgmL and 48 3 μghmL. Trough plasma concentration at steady state 400 mg once daily is 1.0 0.1 μgL. The time of Cmax Tmax is 1 to 3 hours. The mean plasma half-life is 12 3 hours. Coadministration with food may slightly prolong Tmax and reduce Cmax by 16, but these effects are not clinically important. Administration with yogurt or a high fat meal did not significantly affect the AUC. However, coadministered with aluminum-, magnesium-, or calcium-containing antacids markedly reduced oral bioavailability of fluoroquinolones. 