 APOSECTM is a human product derived from lyophilized conditional medium of peripheral blood mononuclear cells PBMC following 24 hours cultivation after irradiation with 60Gy. The soluble factors produced by these factors secretome have regenerative functions and enhance wound healing due to the activation of signaling cascades involved in the cell migration, proliferation and cell survival. The product also possesses strong angiogenic properties as well in vivo and in vitro. APOSECTM is intended for topical use only, to promote healing of wounds in association with standard wound care. Standard wound care includes initial debridement, avoidance and treatment of wound related infections and a non-weight-bearing regime to decrease the pressure on the wound. 