 I. Programmed cell death 1 ligand 1 PD-L1 protein on tumor cells and the expression levels of other markers of inflammatoryimmune signature that may include but not be limited to programmed cell death protein 1 PD-1, tumor necrosis factor receptor superfamily, member 4 OX40, cluster of differentiation CD 73, CD39, T cell immunoglobulin and T-cell immunoglobulin and mucin-domain containing-3 TIM3, glucocorticoid-induced tumour necrosis factor receptor GITRL, cytotoxic T-lymphocyte-associated protein 4 CTLA-4, CD3, CD4, CD8, CD45RO, forkhead box P3 FOXP3, and granzyme by immunohistochemistry IHC andor flow cytometry will be evaluated. 