 - All female subjects must be of non-childbearing potential. For the purposes of this study, this is defined as the subject being amenorrheic for at least 12 consecutive months, or at least 6 weeks post-surgical bilateral oophorectomy with or without hysterectomy, or women who underwent tubal ligation. For women in menopause, menopausal status will be confirmed by demonstrating levels of follicle stimulating hormone FSH 40 - 138 mIUml and oestradiol 20 pgml at entry, unless this information is available in the subjects medical record. In the event a subjects menopause status has been clearly established for example, the subject indicates she has been amenorrheic for 10 years, but FSH andor oestradiol levels are not consistent with a post-menopausal condition, determination of subject eligibility will be at the discretion of the principal investigator following consultation with the sponsor and Medical Monitor 