 10. Patients must have adequate organ and marrow function as defined: Absolute neutrophil count ANC 1.5x109L; WBC 2500 cellsμl; Hemoglobin 9 gdL; Platelets 100x109L; Albumin 2.5 gdL; Serum bilirubin 1.5x institutional upper limit of normal ULN; Total bilirubin 1.5x institutional ULN; Aspartate aminotransferase AST and alanine aminotransferase ALT 2.5x institutional ULN; Serum creatinine 1.5 mgdL OR calculated creatinine clearance Cockcroft-Gault formula 50 mLmin OR 24-hour urine creatinine clearance 50 mLmin; Prothrombin time PTInternational normalized ratio INR and partial thromboplastin time PTT 1.5x institutional ULN 