 - Patients on anticoagulants or anti-inflammatory drugs, including cyclooxygenase inhibitors, AINS, prednisone and immunosuppressive drugs, platelet aggregation inhibitors, except low dose aspirin, ACE inhibitors, antidiabetic agents rosiglitazone, pioglitazone and antioxidants vitamin Eexcept statins or low-dose aspirin 80mgday; 