 Trial Team: The trial will be led by 3 primary investigators Lauralyn McIntyre, Alison Fox-Robichaud, and Alan Tinmouth, who will have responsibility for all aspects of the trial. They have expertise in hematology, transfusion medicine, basic science and clinical trials in critical care. Our team includes co-investigators from the ICU Drs. Lauralyn McIntyre, Joe Pagliarello, Anand Kumar, Sean Bagshaw, Alison Fox-Robichaud, Alexis Turgeon, ED Drs. Ian Stiell, Brian Rowe, Andrew Worster, Marcel Emond, and ICUED Drs. Robert Green, David Easton who will act as clinical champions at each participating site. Many co-investigators have extensive experience in the conduct of multi-centre RCTs Drs. Paul Hebert, Deborah Cook, Dean Fergusson, John Marshall, Ian Stiell, Brian Rowe, Simon Finfer, Alan Tinmouth, Lauralyn McIntyre. The translational co-investigative team includes critical care physicians with expertise in sepsis pathophysiology Drs. Alison Fox Robichaud, Paul Kubes, Patricia Liaw, Anand Kumar, John Marshall, Tao Rui, and Claudio Martin. 