 For these reasons, a number of studies have been carried out with the aim of developing automatic detection systems, which can warn the diabetic patients before blood glucose levels are reduced to the level at which severe neuroglycopenia develops, typically about 2.0-2.5 mmoll. Most studies have evaluated the potential of continuous glucose monitoring CMG to decrease the frequency of hypoglycemia. Although, smaller studies have reported a lower risk of hypoglycemia using CMG compared with conventional glucose measurements 10,11, larger multi-center studies have failed to reproduce these findings 11-14. This could be explained by a low accuracy in the low range of glucose values and delay in detection time during rapid changes using CMG 11,13,14. In fact, CMG only recognizes less than 50 of hypoglycemic events 15. Thus, even with a marginal improvement compared with conventional glucose measurements, CMG is far from the goal of completely avoiding severe hypoglycemic episodes. 