 - The diagnosis of AD will be performed according the Hanifin and Rajka criteria Hanifin JM, Rajka G. Diagnostic features of atopic dermatitis. Acta Derm Venereol Stockhr 92 suppl: 44-70, 1980: to be included in this study, children needed to manifest at least 3 major features and 3 minor features at visit 1 day 1. 