 We will retrospectively identify Crohns disease patients who underwent serial CTE imaging between 2004 and 2008. Approximately 4500 CTEs were performed over this period. We estimate a sample size of 50 Crohns disease patients who have had CTE performed before and after infliximab therapy was initiated. We will analyze each CTE for the presence of penetrating disease, number of inflammatory lesion, length of each lesion, and severity of each lesion degree of enhancement, wall thickness, stratification, vascular engorgement, fatty proliferation, and symmetry. Degree of enhancement and thickness will be graded on a 5-point scale. Stratification, vascular engorgement, fatty proliferation, and symmetry will be treated as dichotomous variables yesno. Only small bowel lesions will be described. A GI radiologist JGF, blinded to the clinical information and previous imaging results, will provide the readings. Comparisons between CTEs will be performed to determine responders all lesions improved, mixed responders not all lesions improved, and refractory no lesion improved. A descriptive pattern of healing will also be recorded for each lesion. Clinical data to be recorded include indication for CTE, time between CTE, dates of each CTE, date on first infliximab infusion, dose of infliximab, interval between infusions, history of penetrating disease, history of surgery, clinical status at imaging remission, flare, or uncertain, medication usage, age, and disease duration. Clinical status at time of imaging will be based on the ordering clinicians global assessment at the time of repeat CTE. This will be determined by a review of the medical record by a gastroenterologist DHB. 