 Phantom limb pain PLP is a frequent consequence of amputation, and it is notoriously difficult to treat. Amputation usually follows traumatic injuries or surgery following vascular diseases, diabetes, osteomyelitis or tumours in cases where the loss of the limb is required for the survival of the patient. The loss of a limb or other body parts is usually followed by the sensation that the lost body part is still present and can be felt. These phenomena are called, respectively, phantom awareness and phantom sensation. In 50-80 of amputees neuropathic pain develops in the lost limb also referred to as phantom limb pain PLP. PLP can be related to a certain position or movement of the phantom limb, and might be elicited or worsened by a range of physical factors e.g. changes in the weather or pressure on the residual limb and psychological factors e.g. emotional stress. It is well known that most treatments available for PLP today, such as pharmacological, surgical, anaesthetic, psychological and other, are ineffective. 