 ETHICAL ASPECTS This study will be conducted in accordance with the Declaration of Helsinki for research involving human subjects and the Good Clinical Practice guidelines. Informed consent will be obtained from the subjects after explanation of the study. The study protocol was approved by the local Institutional Review Board Comité de Protection des Personnes, Sud-Est V, declared to the French authorities insurance : N contract : 124706 Société Hospitalière dAssurances Mutuelles Lyon, France. 