 2. To obtain blood samples from patients who undergo genetic testing to a evaluate the incidence of genetic modifier polymorphisms involved in the development of cancer in BRCA1 and 2 mutation carriers and to compare this incidence to non-BRCA 1 and 2 carriers. b to understand the interaction of genetic modifiers and BRCA1 and 2 in the development of cancer. c to determine the effect of environmental influences on the incidence of polymorphisms in genetic modifiers and on the penetrance of BRCA1 and 2 mutations by linking information from our demographic database to blood samples and 