 - At least 50 of the persistent vincristine neuropathy cases will have the CEP72 promoter variant rs924607 or a coding variant in CEP72 that is predicted to be damaging CADD score 9. The balance of neuropathy cases will either have variants in other genes that are associated with vincristine neuropathy identified in the ongoing genome-wide association study GWAS of 1250 St. Jude Life ALL survivors, or have neuropathy in the absence of known genetic variants altering the risk of neuropathy. 