 - Bilirubin 2.0 mgdL 40 μmolL unless due to Gilberts syndrome in which case the bilirubin should be 3.5 mgdL 59.86 μmolL, aspartate transaminase ASTalanine transaminase ALT 5 × upper limit of normal ULN; hepatic alkaline phosphatase 3.0 × ULN in case of liver metastases higher levels do not hinder inclusion of patients 