 Patients were recruited from the Outpatient Oncology OPO clinic at QMC. After signing an informed consent, patients receiving intravenous chemotherapy were randomly assigned to view a 45-minute humorous DVD or non-humorous DVD. The following measurements were obtained before and after patients viewed the DVD: Edmonton Symptom Assessment Scale ESAS and the state portion of the Spielberger State-Trait Anxiety Index STAI-S to assess symptoms related to cancer and chemotherapy, salivary immunoglobulin A IgA to assess immune function and salivary cortisol to assess emotional stress. In addition, patients, caregivers, and nurses were asked open-ended questions after the intervention to ascertain their impression of the overall intervention experience. Multiple analysis of covariance MANCOVA were be used to analyze changes in ESAS, STAI-S, IgA and cortisol within and between the two groups. 