 All first degree relatives , from 18 years and older from patients who fulfill the criteria for a FGC. These are; 1 all first degree relatives of an individual with diffuse gastric cancer, without proven CDH1 mutation, or members from families with 2 2 or more individuals with gastric carcinoma, at least one 50 yrs, or 3 3 or more individuals with gastric carcinoma, any age, any type, or 4 1 individual with any type gastric carcinoma 40 yrs. 