 - Hepatic and renal function meeting the strata as outlined below; nota bene NB: patients must fulfill both total bilirubin and serum glutamic-oxaloacetic transaminase SGOTaspartate aminotransferase AST criteria and creatinine function to be included in a group; however, if a patients total bilirubin and SGOTAST and creatinine levels indicate different groups, the patient may be enrolled in the indicated group with the greatest degree of liver dysfunction; all liver and renal function tests must be completed within 24 hours prior to the start of treatment; Note: patients on dialysis will not be eligible 