 - Female subjects must be of non childbearing potential including pre-menopausal females with documented medical report verification hysterectomy or double oophrectomy or postmenopausal defined as 12 months of spontaneous amenorrhea or 6 months of spontaneous amenorrhea with serum FSH levels 40 mIUmL and estradiol 40 pgml 140 pmolL or 6 weeks postsurgical bilateral oophorectomy with or without hysterectomy. 