 17. Corrected QT QTc interval 480 msecs; history of acute coronary syndromes including unstable angina, coronary angioplasty, or stenting within the past 24 weeks; Class II, III, or IV heart failure as defined by the New York Heart Association NYHA functional classification system; abnormal cardiac valve morphology documented by echocardiogram subjects with minimal abnormalities including mild regurgitationstenosis can be entered on study with approval from the GSK medical monitor; or history of known cardiac arrhythmias. 