 - Patient must not have ongoing ventricular cardiac dysrhythmias of grade 2 as described by the Cancer Therapy Evaluation Program CTEP Active Version of the National Cancer Institute NCI Common Terminology Criteria for Adverse Events CTCAE; patients with a history of serious ventricular arrhythmia ventricular tachycardia VT or ventricular fibrillation VF 3 beats in a row are also excluded; additionally, patients with ongoing atrial fibrillation are not eligible 