 OUTLINE: This is a 2-part, multicenter, randomized study. Patients are stratified according to gender, weight loss 6 months prior to study entry 5 of body weight vs 5 of body weight, ECOG performance status 0 vs 1 vs 2, radiotherapy technique intensity-modulated radiotherapy vs 3-dimensional conformal radiotherapy, radiotherapy start time at first cycle of protocol chemotherapy, after one cycle of prior non-protocol chemotherapy vs at first cycle of protocol chemotherapy, without prior non-protocol chemotherapy vs at second cycle of protocol chemotherapy, without prior non-protocol chemotherapy and chemotherapy backbone: carboplatin vs cisplatin. 