 6. Important concomitant medical conditions, such as:-Class III or IV congestive heart failure according to New York Heart Association classification-Uncontrolled arterial hypertension defined as screening systolic blood pressure 160 mm Hg or screening diastolic blood pressure 100 mm Hg-Myocardial infarction within 12 months of the screening visit or unstable angina-Severe pulmonary disease requiring hospitalization or oxygen therapy-Diagnosis of multiple sclerosis or other central nervous system demyelinating disease -Presence or history of confirmed blood dyscrasias-Cancer or history of cancer other than resected cutaneous basal cell or squamous cell carcinoma-Serious infection infection requiring hospitalization andor intravenous antibiotics within 1 month of administration of test article administration or active infection at screening or history of recurrent or chronic infection-Open cutaneous ulcers-Patients with known chronic infections as positivity to HIV, hepatitis B surface antigen HBsAg, or hepatitis C virus HCV -Active tuberculosis infection local guidelines for appropriate screening and treatment of tuberculosis in the setting of anti-TNF therapy must be followed- Any condition that, in the investigators judgment, might cause this study to be detrimental to the subject 