 Haematology and biochemistry panels will be done as per standard of a care - Full blood counts including haemoglobin, white cell count, platelet count, haematocrit and differential white cell count, erythrocyte sedimentation rateESR, sodium, potassium, chloride, urea, creatinine, protein, albumin, crp, liver function tests and quantitative immunoglobulin IgA, Immunoglobulin G, IgM. Participants will also have HIV, hepatitis B, hepatitis C, HTLV and syphilis screens performed at visit 1. This analysis will be performed at Cork University Hospital CUH laboratories. All laboratory results will be reviewed and reports signed the investigators and recorded in the patients case repot form CRF. 