 Older adults are at increased risk of various chronic diseases, in which inadequate levels of vitamins and minerals may play a significant role, including cardiovascular disease, Alzheimers disease, liver disease, and cancer. Most adults in the United States do not meet the Recommended Dietary Allowance RDA or Adequate Intake AI of many vitamins and nutritionally-essential minerals from diet alone, including vitamins A, C, D, E and K, calcium, magnesium, and potassium. Older adults are particularly susceptible to micronutrient inadequacies because of limited absorption, increased requirements, or - in the case of vitamin D - decreased synthetic capacity in the skin. Thus, there is a strong rationale for supplementing the diets of older adults with a multivitaminmultimineral supplement, such as Centrum Silver. However, little is currently known about the bioavailability of the Centrum Silver formula in this age demographic. 