 The purpose of this study is to assess the independent effects of both a 4-Factor prothrombin complex concentrate PCC - Kcentra and Tranexamic acid TXA on the bleeding parameters bleeding duration and blood volume following a punch biopsy, in addition to assessing their effects on the anticoagulantpharmacodynamic prothrombin time and endogenous thrombin potential changes induced by rivaroxaban at steady state, to better understand their potential role in bleeding reversal. 