 - Time interval from final definitive breast surgical procedure to the start of external beam therapy or to brachytherapy is less than 12 weeks 84 days. If patients receive chemotherapy the radiotherapy can be started before systemic treatment within 12 weeks. The radiation therapy can be also given in the interval between the chemotherapy courses. It is also possible to start radiation therapy after chemotherapy is completed according local protocols as soon as possible within 4 weeks after chemotherapy. 