 Participants: The study will enroll 50 adult patients who are identified with early suspected septic shock from the emergency department ED and the intensive care unit ICU. Patients need to be hypotensive or require vasopressor agents, have at least 2 systemic inflammatory response syndrome criteria, and have no other form of shock e.g., cardiogenic, obstructive, or hemorrhagic shock and no previous ICU admission for severe sepsis or septic shock after receiving at least 1 litre of crystalloid and not more than 250 mls of colloid fluid within 8 hours of the first hypotensive event. 