 Urea solution will be then prepared for eye drops purpose by enhancing its efficacy using the polymeric NPs based on the amphiphilic block copolymer PluronicF-127 PF which is an A-B-A-type triblock copolymer consisting of polyoxyethylene PEO units A and polyoxypropylene PPO units B with a thermoreversible gelation property that has a hydrophilic nontoxic property widely used as a pharmaceutical excipient for its stabilizing properties and capability to increase the solubility. 