 1. Presence of any one of the following medical conditions: active infection, uncontrolled diabetes mellitus, MI, CVA or TIA within 3 months of screening visit, symptomatic cardiomyopathy congestive heart failure, symptomatic coronary artery disease, uncontrolled hypertension sitting systolic BP 80 mm Hg or 160 or diastolic BP 100 mm Hg, oxygen-dependent severe pulmonary disease, systemic lupus erythematosus SLE, cancer other than basal cell skin cancer less than 5 years previously, HIV or other immunosuppressing disease, positive PPD test or any history of mycobacterial disease, chronic hepatitis B or hepatitis C, history of multiple sclerosis, transverse myelitis, optic neuritis, chronic inflammatory demyelinating neuropathy, epilepsy, or other chronic serious medical illnesses 