 The aim of this study is to determinate the effect of invasive pain treatment splanchnicectomy in patients with advanced pancreatic cancer on subjective pain perception at rest, in movement and after meals measured with the BPI, QLQ- C30 and FACIT questionnaires, and suffering measured with PRISM projection test, the use of painkillers during the disease and patients overall survival. Moreover the investigators want to check if early performance of splanchnicectomy on lower steps of analgesic ladder WHO is combined with better therapeutic effect of this treatment. 