 A total of 28 subjects will be enrolled into the study, including 6 normal subjects Creatinine Clearance CrCL 80 mLmin, 9 subjects with mild impairment CrCL 50 to 80 mLmin, 6 subjects with intermediate impairment 30 to 50 mLmin and 7 subjects with severe impairment CrCL 30 mLmin. 