 We hypothesize that one-cycle induction chemotherapy may also help to identify chemo-responsive esophageal cancer patients who are highly treatable by definitive CCRT.in order to test this hypothesis, we thus propose this phase II clinical study to verify the role of response to one-cycle induction chemotherapyin the prediction of pathologic complete response rate to CCRT and tje outcomes for patients with loco-regional esophageal cancer. 