 Blood white cell count3.0109L, Neutrophile cell count 1.5109L Platelet count 100109L Total bilirubin TB 1.5 times upper limit of normal Aspartate aminotransferase AST, alanine aminotransferase ALT 2 times upper limit of normal; for subjects with hepatic metastasis, AST, ALT 5 times upper limit of normal Creatinine clearance50mlmin 