 However, it is not known how best to treat people with cryptococcal antigen in their blood, who dont otherwise yet have symptoms of infection around their brain. If no treatment is given, almost all people will develop infection of the brain andor die. International guidelines suggest using both HIV medicines and an anti-fungal medicine, called fluconazole, to treat this early infection. However, despite this treatment approximately 1 in 4 people may get sick andor die. 