 Considering the high activity of Velcade alone in untreated patients and the superior activity of combinations of Velcade with either Doxil or dexamethasone, we propose combining all three agents as a VDd combination i.e. Velcade, Doxil, and dexamethasone. We hypothesize that this combination will have similar or better efficacy compared to other commonly used combinations for initial therapy i.e. thalidomide with dexamethasone, dexamethasone pulses, VAD or melphalan and prednisone or Velcade alone and higher than these treatment regimens CR rate with acceptable toxicity. 