 - Therapeutic level dosing of warfarin can be used with close monitoring of PTINR by the site; exposure may be decreased due to enzyme induction when on treatment, thus warfarin dosing may need to be adjusted based upon PTINR; consequently, when discontinuing dabrafenib, warfarin exposure may be increased and thus close monitoring via PTINR and warfarin dose adjustments must be made as clinically appropriate; prophylactic low dose warfarin may be given to maintain central catheter patency 