 Anecdotal evidence suggested that pressure on specific foot muscles decreases symptoms of moderate to severe primary restless legs syndrome. In the RESTIFFICTM study, patients served as their own negative controls, wearing the RESTIFFICTM devices intermittently, while completing surveys related to RLS throughout the study. Physicians also completed surveys related to quality of life. Meta-analysis was used to compare RESTIFFICTM to historic reports of ropinirole and placebo pill. Demographics, disease severity,inclusionexclusion criteria, assessment tools were similar among studies. 