 The primary hypothesis to be tested is that vitamin E supplementation of 400 IUday exerts positive arterial wall effects by reducing progression of early atherosclerosis in healthy individuals 40 years old or older without clinical evidence of cardiovascular disease CVD. Ultrasonography will be used to measure the rate of change of the distal common carotid artery CCA far wall intima-media thickness IMT. The beneficial effects of vitamin E supplementation are expected to occur with or without a change in LDL-C levels. 