 - Women of child-bearing potential i.e., women who are pre-menopausal or not surgically sterile must use acceptable contraceptive methods abstinence, intrauterine device IUD, oral contraceptive or double barrier device, and must have a negative serum or urine pregnancy test within 1 week prior to beginning treatment on this trial. Nursing patients are excluded. Sexually active men must also use acceptable contraceptive methods. Pregnant and nursing patients are excluded because the effects of the combination of SU11248 Sutent and sirolimus on a fetus or nursing child are unknown. 