 RATIONALE Recent studies in women at hereditary high risk to develop ovarian cancer indicate that high grade serous carcinomas arise from ectopic andor dysplastic tubal epithelium. Historically, in pre-menopausal women undergoing a hysterectomy for benign indications such as bleeding disorders, fibroids and adenomyosis adnexa, including the Fallopian tubes, are left in situ. However, removing the tubes during a hysterectomy potentially prevents the development of serous ovarian carcinomas. Such a simple preventive procedure should avoid serious adverse effects of adnexectomy, like premature ovarian failure POF. 