 In the last few years Nitazoxanide was evaluated as a single agent therapy for H. Pylori infection showing controversed results.. However NTZ based regimens were recently studied showing interesting results without the apparent problem of resistance as Metronidazole with nearby cost.Moreover ;Levofloxacin,PPI,NTZDoxycycline LOAD regimen with very good results in H.pylori infection 90 cure rate..But uptil now there are no actual similar reported trials in Egypt. 