 In this amendment we will enroll more patients to clarify the above findings: 1 the association between HBV reactivation and survival; 2 diagnostic value of quantitative HBsAg and anti HBc tests on HBV reactivation; 3 whether host factors DNA polymorphism may help predict HBV reactivation. A larger patient cohort is needed to identify 1 baseline features that may help predict HBV reactivation, and 2 on-treatment features that may help timely anti-viral therapy. 