 2. Transfusion-dependent anemia from HHT-related bleeding epistaxis from nasal mucosal telangiectases or gastrointestinal bleeding from gastrointestinal telangiectases defined as a hemoglobin Hb 9gdL with transfusion of at least one unit of packed red blood cells within the past 6 months or Hb 11gdL in females or 13gdL in males with transfusion of at least 5 units of blood within the past 6 months. Patients must be on a stable dose of iron or intolerant of iron. Patients must have failed traditional treatment options. 