 - Manual TIVA: Manually titrated IV anesthetics are routinely done in the operating room as an alternative to inhalational anesthetics. Propofol, ketamine and sufentanil PKS administration will be done via a three way stop cock connected directly to the IV catheter to minimize dead space volume. PKS solution will contain total of 50ml. Propofol 10mgml, Ketamine 1mgml will be omitted in subsequent preparations after first 50ml, Sufentanil 0.25 mcg-ml. Drug will be administered using an Alaris infusion pump titrated by the anesthesiologist based on blood pressure and heart-rate as is traditionally done and is standard of care with intravenous anesthetics. 