 - Exclusion criteria for screening ECG a single repeat is allowed for eligibility determination: Heart rate 45 and 100 beats per minute bpm Males; 50 and 100 bpm females; For both Males and Females: PR Interval 120 and 220 msec, QRS duration 70 and 120 millisecond msec; QTc interval Fridericias 450 msec. Notes: A heart rate from 100 to 110 bpm can be rechecked by ECG or vitals within 30 minutes to verify eligibility. Evidence of previous myocardial infarction Does not include ST segment changes associated with repolarization. Any conduction abnormality including but not specific to left or right complete bundle branch block, AV block 2nd degree or higher, WPW syndrome. Sinus Pauses 3 seconds. Any significant arrhythmia which, in the opinion of the principal investigator or GlaxoSmithKline medical monitor, will interfere with the safety for the individual subject. Non-sustained or sustained ventricular tachycardia 3 consecutive ventricular ectopic beats. 