 - Current use of a prohibited medication. Patients receiving any medications or substances that are strong inhibitors or inducers of CYP3A or CYP2C8 are ineligible. Current use of, or intended ongoing treatment with: herbal remedies e.g., St. John s wort, or strong inhibitors or inducers of P-glycoprotein Pgp or breast cancer resistance protein 1 Bcrp1 should also be excluded. 