 At Visit 1 a complete medical history including a list of current medications, reproductive status and menstrual history for females, physical examination including height and weight, and vital signs will be obtained. Three consecutive blood pressure measurements will be performed in the sitting position using an automated arm cuff and only individuals with a blood pressure less than 14090 mmHg will be considered eligible. A urinalysis will be performed and blood will be drawn after an overnight fast for measurement of complete blood count hematocrit, white cells and platelets, plasma glucose, free T4 and TSH; SMA 20, lipid profile; hemoglobin A1c levels HbA1C; free fatty acids, insulin and C-peptide concentrations and for a pregnancy test females only. An EKG also will be performed. All diabetic patients who are deemed healthy and meet eligibility criteria see below based upon physical exam, medical history and screening laboratory tests will be invited to participate in the study. 