 CON group receive only conventional standard treatment. For your first trial these outcomes are too ambitious. Just do some initial physiologic experiments first to understand what happens to CHF pts when you perform HTEA. Then follow those pts for the next few weeksPrimary end pointsI would first start with short term outcomes. One could use a model such as that outlined in the levosimendan trial : Re-hospitalizing rate caused by severe cardiac failureOver what time? I would suggest 4 weeks, re-hospitalizing rate caused by other cardiovascular diseases; NYHA cardiac function grading, living quality evaluation, 6 minute walking distance, echocardiography,When? At 24 hours, at 4 weeks? dynamicIs this the same as an ETT? electrocardiogram, as well as the peripheral blood NT-proBNP At 24 hrs? 48 hrs? 4 weeks?changes would be compared. The statistical plan is missing. Is 50 pts adequate to evaluate the early efficacy. 