 - Use or planned use of any drugs with significant anti-malarial activity, such as doxycycline, clindamycin, azithromycin, or trimethoprimsulfamethoxazole among others during the study period subjects can withhold the use of these medications during the study period if approved by their primary care physicians, at the minimum starting from four weeks before vaccine administration until four weeks after becoming parasitemic Any confirmed or suspected immunosuppressive or immunodeficient condition, including HIV infection and history of splenectomy 