 For each heart transplant patient, 10 to 11 blood samples 5 mL each will be collected following dosing of he immunosuppressive drugs at T0, T20, T40, T60, T90, T2h, T3h, T4h, T6h, T8h and T10h T12h for inpatients, at several post-transplant periods 7 to 15 days, 1 month, 3 month and 1 year after transplantation. One more blood sample will be taken at D7-14 for pharmacogenetic analyses. 