 3. Measurable disease PN: Subjects must have at least one measurable PN, defined as a lesion of at least 3 cm measured in one dimension. Subjects who underwent surgery for resection of a PN are eligible provided the PN was incompletely resected and is measurable. Measurable disease OPG: Subjects must have one measurable OPG lesions according to RANO 1.1 i.e. Tumour 10 x10mm in maximal perpendicular dimensions on an axial image on MRI with 5 mm reconstruction interval. 