 - Currently active second primary malignancy, including hematologic malignancies leukemia, lymphoma, multiple myeloma, etc., other than non-melanoma skin cancers, non-metastatic prostate cancer, in situ cervical cancer, and ductal or lobular carcinoma in situ of the breast. Subjects are not considered to have a currently active malignancy if they have completed anti-cancer therapy and have been disease free for 2 years. 