 9. Systemic chemotherapyradiotherapyinvestigational therapy within 14 days with the exception of hydroxyurea and steroids prior to starting therapy. For patients receiving ALL maintenance with 6-mercaptopurine, methotrexate, vincristine, and steroids - these agents should be discontinued at least 48 hours prior to start of study drugs. For patients on oral targeted therapies such as imatinib, dasatinib, ponatinib, - these agents should be discontinued at least 48 hours prior to start of study drugs. 