 Prevalence data of non-compliance in solid organ transplantations fluctuate is reported in up to 39 of transplant recipients z. B. for lung transplantations 13 - 22; Kugler et al.. Non-compliance with immunosuppressive therapy is associated with an increased risk of late-acute rejections and the development of chronic transplant dysfunction. Chronic transplant dysfunction bronchiolitis obliterans- syndrome-BOS is the second most causing for organ failure after the first year following lung transplantation and often leads to re-transplantation or death. Preventative procedures for improving the compliance are simplification of the dose of the immunosuppressants a once daily dose instead of a twice daily dose, the prescription of an immunosuppressants with less side-effects and to raise the patient s awareness for having the greatest responsibility for the efficacy of his therapy. Prospective studies and metaanalysis revealed that the probability for a good compliance can be more than doubled at once daily administration in comparison to twice daily and the best predictor for a good compliance is an easy therapy. For this reason we want to investigate the extent of profit for our lung transplant patients receiving once daily basis immunosuppression in comparison to those who receive twice daily dose. 