 At enrollment baseline, the subjects medical and pharmacological history and results of physical examination will be recorded. Historical data on seizure types and seizure frequency will be collected, and assessment of adverse effects of AED therapy by unstructured interview and application of the Adverse Event Profile AEP 21-item questionnaire developed by Baker et al. 1997 . The AEP questionnaire and the physical examination will be repeated on day 67. Occurrence of seizures will be recorded daily. 