 Blood samples are collected periodically for biomarker analysis. Samples are analyzed for protein expression i.e., CD38, CD20, and ZAP70 by flow cytometry; quantitative immunoglobulins, β2-microglobulin, and T-cell subsets by electrophoresis; IgVH mutation status; and cytogenetics i.e., 12, del 13q, del 11q, and del 17p by FISH. 