 This randomized controlled trial is designed to evaluate whether a behavioral intervention that includes three components: 1 reminder letters and education materials delivered before the clinic visit, 2 telephone recalls after the visit for those who originally decline the vaccine, and 3 telephone reminders for those who miss the 2nd andor 3rd doses, increases 1 and 3 dose coverage of the human papillomavirus HPV vaccine series among adolescent girls attending four Parkland primary care clinics in Dallas county. 