 9. History or evidence of clinically significant cardiac disease such as symptomatic arrhythmia, anginaischemia, coronary artery bypass graft surgery or percutaneous transluminal coronary angioplasty, uncontrolled atrial fibrillation, CHF with a left ventricular ejection fraction 40, uncontrolled hypertension SBP 190 mmHg or DBP 100 mmHg, HR outside normal range of 50-100 bpm for women and 45-100 bpm for men 