 Sirolimus will be provided as oral solution 1 mgml to allow for precise dose adjustments. The tablet and oral solution forms are clinically equivalent 2003. Sirolimus will be administered orally twice daily approximately every 12 hours for a 28 day course with no rest period between courses. Sirolimus should be taken by the patient consistently either with or without food. Sirolimus should NOT be taken with grapefruit juice or with other effectors of CYP3A4 see section 4.1.7. Dietary habits around the time of sirolimus intake should be as consistent as possible throughout the study, and in particular, during those periods when samples are being taken for pharmacokinetic analyses if applicable. Limited exposure to sunlight and wearing sunscreen is recommended while taking this drug. If you miss a dose, treatment should continue without making up the missed dose. 