 To date, several published trials have been described using the single high-dose bolus SHDB of tirofiban in various clinical settings. Taken together, more than 600 patients received the SHDB of tirofiban in these clinical trials without evidence of a greater than expected increase in the frequency of bleeding events or thrombocytopenia. A variety of clinical, angiographic, and echocardiographic endpoints all consistently demonstrate that the SHDB of tirofiban is superior to placebo and appears to be comparable to abciximab. 