 Danshen and Gegen DG are commonly used Chinese herbal medicine in the treatment of cardiovascular diseases. DG study has been extensively researched and continued at The Chinese University of Hong Kong CUHK for their antioxidative and vasodilator properties, modulate anti-atherosclerosis and improve arthrogenic athophysiology. Three randomized trials were completed at the CUHK showing DG improved lipid profile, vascular function and thinned down the internal layer of the carotid artery. One may expect the same with lower limb arteries. Extensive clinical experiences of use in China and Hong Kong indicated that DG are well tolerated and safe. 