 The study is based on biased coin design, and the concentration of LA for the next patient is determined by the result of the last one. In the case of block failure, the concentration will be increased by 0.025. Conversely, block success will result in either a reduction in concentration by 0.025 probability 11 or no change in concentration probability 89. A blinded assistant will assess sensory and motor blockade in each nerve territory the median, radial, ulnar and musculocutaneous nerves at 10-min intervals up to 30 min after completion of the block. Finally, MEC90 is calculated by isotonic regression. 