 - Any medical condition or use of medication e.g., active autoimmune disease, immunodeficiency or corticosteroids which might make it difficult for the patient to complete the full course of treatments or to respond immunologically to vaccines is grounds for exclusion, at the discretion of the Principal Investigator or co-Principal Investigators. Patients may not have taken systemic corticosteroids orally or intravenously within the previous 6 weeks. Inhaled or nasal steroids are permitted. 