 - For cohort D antiphospholipid antibodies a. Subjects in group D must have at least one positive antiphospholipid antibody within the last 8 weeks andor previous confirmed antibodies 2 or more occasions at least 12 weeks apart : i. Positive lupus anticoagulant ii. anticardiolipin antibody IgM or IgG 40U GPL iii. anti-β2 Glycoprotein1 antibody titer 35 units 