 The aim of current study is to investigate whether the HBsAg clearance rate can be improved if applying RGTResponse-Guided Therapy strategy in HBeAg positive CHBchronic hepatitis B patients treated by nucleoside analogueNUC achieved HBVDNA1000copiesml,and HBsAg5000IUml; HBeAg100PEIUml or470sco, combined with PEG-IFN a-2a for 24 weeks. 