 - Burdens: Patients will have to undergo three electromyographic EMG tests, which will normally take place during the course of the whole treatment, therefore patients will have to visit the hospital to be measured. To minimize this burden, the EMG-measurements will be planned on the same day, the patient has to visit the hospital for reasons regarding hisher regular chemotherapy-treatment. Only surface patch electrodes will be used no needle electrodes. All other information will be obtained from the patients files blood samples, physic evaluations, etc these are considered to be part of the routines of treatment. When EMGs can not be measured, audiograms will be used, these audiograms are also part of the routines of treatment, so are not considered an extra burden. Patients will have to fill in Quality of Life questionnaires. 