 ii Women over 50 years old would be consider postmenopausal if they have been amenorrheic for 1 year or more following cessation of all exogenous hormonal treatments, radiation-induced oophorectomy with last menses 1 year ago, chemotherapy-induced menopause with 1 year interval since last menses. Or surgical sterilisation bilateral oophorectomy or hysterectomy. 7. Male patients should be willing to use barrier contraception for a specified period 8. A lesion that can be accurately assessed at baseline by CT or magnetic resonance imaging MRI and is suitable for repeated assessment in accordance with RECIST 9. Patients must have a life expectancy 16 weeks 10. Patients who can remain in Hospital from Cycle 0 Day 1 up to at least the completion of Cycle 1 Day 9 11. Patient is willing to provide fresh or archival tumour sample and biomarker blood sample. 