 - Clinical signs of decompensated liver disease at baseline. These may include but are not limited to:serum bilirubin 2.5 mgdL 43 μmolL, prothrombin time 2 second prolonged above ULN,serum albumin 35gL,history of ascites, variceal bleeding, or encephalopathy,Alanine aminotransferase ALT 10 times ULN at screening or history of acute exacerbation leading to transient decompensation. 