 The study had a power of 80 on the basis of an assumed 2-year survival rate of 62.4 in the experiment group and 36.9 in the control group, with use of a two-sided log-rank test at a level of significance of 0.05. The recruitment period would be 2 years, and the follow-up period would be 2 years, and 15 of patients would drop out early or be lost to follow-up. A total number of 101 patients were to be recruited with stplan 4.5 software calculation. Department of Biostatics, MD Anderson Cancer Center, University of Texas,USA The patients in the experimental group received the TPF induction chemotherapy for 2 cycles followed by radical surgery and post-operative radiotherapy. The palpable edges of the primary lesion both the longest and shortest axis were marked before induction chemotherapy by at least four points, which were 0.5cm away. The patients in the control group received the radical surgery and post-operative radiotherapychemoradiotherapy. 