 - Female of non-reproductive potential FNRP is eligible to participate in this study if she meets at least one of the following conditions: a Females with one of the following procedures documented and no plans to utilize assisted reproductive techniques e.g., in vitro fertilization or donor embryo transfer: bilateral tubal ligation or salpingectomy, hysteroscopic tubal occlusion procedure with follow-up confirmation of bilateral tubal occlusion, hysterectomy, bilateral Oophorectomy surgical menopause; b Post-menopausal women including Females 60 years of age or older, A practical definition accepts menopause after 1 year without menses with an appropriate clinical profile, e.g., age appropriate, more than 45 years, in the absence of hormone replacement therapy HRT or medical suppression of the menstrual cycle e.g., leuprolide treatment. In questionable cases for women less than 60 years of age, a blood sample with simultaneous follicle stimulating hormone and estradiol falling into the central laboratorys post-menopausal reference range is confirmatory these levels need to be adjusted for specific laboratoriesassays. Females fewer than 60 years of age, who are on HRT and wish to continue, and whose menopausal status is in doubt, should not be enrolled in this study. Otherwise, they must discontinue HRT to allow confirmation of post-menopausal status prior to study enrolment. For most forms of HRT, at least 2 to 4 weeks will elapse between the cessation of therapy and the blood draw; this interval depends on the type and dosage of HRT. Following confirmation of their post-menopausal status, they can enroll into the study and resume use of HRT. 