 Recruited participants will have no more than three visits. Visit 1: This will include screening to ensure participants meet the inclusion criteria and possess none of the exclusion criteria. The MRI evaluation visit 2 at 1.5 and then 3T will be performed for all those recruited before starting biological therapy at week 0. The second MRI scanning session will be 12 weeks after biological therapies onset visit 3. The period between scanning MRI visit 2 and biological therapy onset will be a maximum of 4 weeks 