 11. Patients must have adequate organ function Hemoglobin 8 g100 ml, Neutrophils 1,000mm3, Platelets 75,000mm3, total bilirubin 1.5 times the upper limit of normal ULN for age except for Gilberts syndrome patients, serum alanine aminotransferase ALT 2.5 ULN for age, aspartate aminotransferase AST 2.5 ULN for age , serum creatinine 1.5 x ULN for age 