 This randomized study will be approved by the local ethics committee of South Egypt Cancer Institute, Assuit University, Egypt after written informed consent. This study will include approximately 60 ASA I-II cancer patients with age range 18-60 years, weight 50- 85 kg who will be scheduled for lower abdominal cancer surgery abdominal hysterectomy, oophorectomy and radical cystectomy. Exclude from the study Patients with known drug allergy to study drugs, significant cardiac, respiratory, renal or hepatic disease, coagulation disorders and those with psychiatric illnesses that would interfere with perception and assessment of pain. Preoperatively, patients will be taught how to evaluate their own pain intensity using the Visual Analog Scale VAS, scored from 0-10 where 0 no pain and 10worst pain imaginable. 