 Oxidative Stress evaluation: plasma parameters lipid peroxide derivatives, semicarbazide sensitive oxidase amine activity, erythrocyte and leukocyte cell parameters reduced and oxidised glutathion, dismutase superoxide activity SOD Cu and Mn dependent, glutathion peroxidase, and catalase, urinary parameters isoprostane F2 Evaluation of consequences of oxidative stress on atherogenesis processes: inflammatory parameters CRP, TNFa, IL 6, adhesion molecules VCAM 1, ICAM 1, P selectine, adipokines leptine, resistine, adiponectine, coagulation factors PAI 1, platelet and endothelial microparticles, The pre and postprandial glycaemic stability of each patient will be monitored using PDA phone systems, and HbA1c will be measured at M0, M3 and M6. 