 Although methylene blue has been used effectively to identify areas of SIM in several studies, its superiority in identifying dysplasia in the setting of Barretts esophagus has been inconclusive. In all studies to date dysplastic yield was equivalent or better than protocol techniques while requiring fewer biopsies. Variations in study design, staining technique and inexperience in staining interpretation are some of the reasons. Our goal is to build on the techniques that have been shown to be effective, standardize them for the purposes of our study, and to objectively evaluate if MB directed biopsies are useful in screening Barretts patients for dysplasia. At the time of EGD when length of Barretts is determined, patients will be stratified into either intermediate 2-4cm or long segment 4cm Barretts. Short segment Barretts esophagus patients will not be considered, as MB techniques have not proved beneficial in dysplasia detection as previously described 7. 