 Retinal venous occlusive disease, which includes central retinal vein occlusion CRVO and branch retinal vein occlusion BRVO, is second only to diabetic retinopathy as a cause of vision loss due to retinal disease. The main cause of vision loss in all of these disorders is the development of macular edema. Current clinical practice based on randomized controlled clinical trials ETDRS, BVOS employs laser photocoagulation, either in a focal or grid pattern, to treat macular edema associated with diabetic retinopathy and branch retinal vein occlusion. Unfortunately, laser photocoagulation is ineffective in central retinal vein occlusion CRVO, and no proven therapy exists for CRVO. 