 - Any of the following comorbid conditions: NYHA class III-IV heart disease, recent myocardial infarction 6 months prior to registration, uncontrolled infection, infection with the human immunodeficiency virus HIVAIDS, serological evidence of active hepatitis B infection HBsAg or HBeAg positive or positive hepatitis C serology, as further severe immunosuppression with this regimen may occur 