 The eye drop will be prepared by an ionic gelation method using the tripeptide antioxidant glutathione GSH with the pluronicF-127 PF as carriers to urea delivery for the target of cataract therapy. Pluronic F127 PF127, which can be self-assembled into micelles upon increasing concentration or raising temperatures, is used to decorate the water-soluble urea via a chemical reaction. Next, the GSH is incorporated into the hydrophobic poly propylene oxide compartment of PF127 using electrostatic interactions between the positively charged GSH and the negatively charged PF. The prepared NPs were then characterized using transmission electron microscopy TEM. The average size of urea-loaded PF 127GSH NPs was 140 nm. 