 Approaches: This Aim requires the retrieval and cutting of the archive material for a nested control study. The estimate number of cases reach outcome is 30 5 of FV group 100 25 of control group 100. Additionally, 60 matched controls will be selected matched by gender, age, smoking habit, and anatomical site. This Aim is critical to demonstrate a shift in field, sparing normal tissue while catching high-risk occult tissue. Samples for the nested molecular analysis will be performed in Rosins Lab for microsatellite analysis and Cancer Imaging at BC Cancer Agency Dr. MacAulay for qualitative Pathology. The protocols used to analyze these samples have been published. 