 Patients unable to give informed consent, with opportunistic infection in the last 3 months, malignancy or infection requiring intravenous antibiotics within 2 months prior to enrollment, myoskeletal contraindication to exercise requirement for systemic anticoagulation, participating or participated in an investigational drug or medical device study within 30 days or five half-lives, pregnant, breast feed or female of childbearing potential who does not agree to remain abstinent or to use an acceptable contraceptive regimen, lactate dehydrogenase 300UL, prolonged heart wave QT interval as defined by corrected QT QTc 460 msec in males and 470 msec in females on screening electrocardiogram ECG, known current alcohol or drug abuse, known or suspected hypersensitivity to the study medication or any of its ingredients, 