 - No unstable angina or myocardial infarction within the previous 6 months; no symptomatic congestive heart failure, New York Heart Association NYHA grade II or greater; no history of aortic dissection or presence of aneurysm 6 cm or at high risk for rupture; no serious cardiac arrhythmia requiring medication history of chronic atrial fibrillation or other atrial arrhythmia with controlled rate on medication is allowed; no clinically significant peripheral vascular disease manifested by intermittent claudication or need for vascular intervention; no history of aortic dissection; no history of any central nervous system CNS cerebrovascular ischemia or stroke within the last 6 months; no active serious infection 