 1. Previous exposure to any anti-interleukin-1 treatment, to corticosteroids within 1 month prior to Screening, to intra-articular hyaluronic acid injection into hand joints within 6 months prior to Screening, to any immunosuppressive biologic therapy within 1 month or 5 half-lives whichever is longer prior to the first dose of study drug, OR current use of immunosuppressive oral medications within 3 months or 5 half-lives whichever is longer prior to the first dose of study drug. 