 The human gastrointestinal system is populated with a variety of symbiotic microorganisms, namely microbiota. Its total weight is approximately 2 kilograms, containing trillions of microorganisms. The microbiome is the total genetic metagenomic data of the microbiota. In recent years, the development of efficient methods for genome sequencing and bio-informatics has enabled fast and accurate quantification and qualification of the microbiome, made microbiome analysis leading method of microbiota research. 