 There are limited observational mechanistic studies designed to understand the potential biological mechanisms for albumins potential protective effects in sepsis. Moreover, mechanistic data in the clinical trial setting are lacking. The PRECISE pilot RCT Five Percent Albumin versus Normal Saline as Fluid Resuscitation Strategies for the Management of Early Suspected Septic Shock will help to understand the biological mechanisms of albumin in early septic shock and explore feasibility issues in preparation for a large RCT. 