 AZD5363 is a potent, selective inhibitor of the kinase activity of the serinethreonine AKTPKB protein kinase B that is being developed as a potential treatment for solid and haematological malignancies. AKT is part of the AGC family of kinases. Mammalian cells express three closely related AKT isoforms: AKT1 PKBa, AKT2 PKBß and AKT3 PKBgamma, all encoded by different genes. 