 Nucleic acid polymers NAPs utilize the sequence independent properties of phosphorothioated oligonucleotides to target apolipoprotein interactions involved in the formation of HBV subviral particles SVPs which are comprised mainly of the hepatitis B surface antigen protein HBsAg. The effect of NAPs is to block the formation of SVPs inside infected hepatocytes which prevents their secretion. As SVPs account for 99.99 of HBsAg in the blood, NAPs are an effective approach for clearing HBsAg from the serum of HBV infected patient. 