 3. Confirmed histological diagnosis of metastatic malignancy with dominant liver metastases without standard therapeutic options for treatment including chemotherapy or surgery. Dominant liver metastases are defined according to the Response Evaluation Criteria in Solid Tumors RECIST methodology, see Appendix IV as the diameter of all metastases in the liver must be more than 200 of the sum of the diameters of all soft tissue lesions outside the liver. 