 - HIV or HBV co-infection, known cirrhosis, prior history of clinical hepatic decompensation ascites, jaundice, encephalopathy or variceal hemorrhage, alcoholic or other forms of chronic liver disease, evidence of hepatocellular carcinoma α-fetoprotein 50 ngmL, creatinine clearance 80 mLmin using Cockcroft-Gault equation, hemoglobin 10 gdL, neutrophils 1500mm3, abnormal thyroid function tests TSH 2.5 μIUmL, free T4 ULN, or, a positive test result for illicit drugs, alcohol, or drug abuse within the past 12 months. Subjects who have significant gastrointestinal, thyroid, renal, cardiovascular, pulmonary, oncologic, or neurological disease, or who are currently receiving immunomodulators corticosteroids, etc, investigational, nephrotoxic or hepatotoxic drugs e.g phenytoin, carbamazepine, INH, azole anti-fungal agents such as ketoconazole, and aminoglycoside antibiotics, etc., non-steroidal anti-inflammatory agents, ibuprofen or acetaminophen on a daily basis will also be excluded. 