 9. Female subjects must be post-menopausal one year or greater without menses, surgically incapable of childbearing, practicing abstinence or practicing two effective methods of birth control. Acceptable methods may include intrauterine device, spermicide, barrier and hormonal contraception. A female subject must agree to practice an acceptable method of birth control during study period and for 12 weeks after study terminates. All female subjects regardless of menopausal status or surgical history must have had a negative urine pregnancy test urine betahuman chorionic gonadotropin hCG during the screening visit. The urine pregnancy test must be sensitive to at least 50 mUmL of beta-hCG. 