 1 Clinically suspected or documented relapseprogression, in first or second relapse following at least one cycle of an asparaginase-based chemotherapy regimen OR 2 Initial disease or first or second relapse and unable to tolerate one full cycle of asparaginase-based chemotherapy regimen OR b High-risk disease stage IIIIV, KPI groups 3-4 or IPI intermediate-high prior to second CR regardless of previous chemotherapy. 