 - Patients must have measurable disease, in addition to at least one lesion in a reasonably safe location for study-related biopsies; measurable disease is defined as at least one lesion that can be accurately measured in at least one dimension longest diameter to be recorded for non-nodal lesions and short axis for nodal lesions as 20 mm 2 cm by chest x-ray or as 10 mm 1 cm with computed tomography CT scan, magnetic resonance imaging MRI, or calipers by clinical exam 