def subset_vcf(in_file, region, out_file, config):
    """Subset VCF in the given region, handling bgzip and indexing of input.
    """
    work_file = vcfutils.bgzip_and_index(in_file, config)
    if not file_exists(out_file):
        with file_transaction(config, out_file) as tx_out_file:
            bcftools = config_utils.get_program("bcftools", config)
            region_str = bamprep.region_to_gatk(region)
            cmd = "{bcftools} view -r {region_str} {work_file} > {tx_out_file}"
            do.run(cmd.format(**locals()), "subset %s: %s" % (os.path.basename(work_file), region_str))
    return out_file
Subset VCF in the given region, handling bgzip and indexing of input.