You can place multiple Inertialization or Dead Blending nodes in your graph as needed, and each will handle inertial blend requests from their source pose. This means you can perform inertial blending in different spaces. For example, you may want to create separate Inertialization or Dead Blending nodes that operate on your character's upper and lower body separately, followed by a Layered Blend per bone node to blend them together into a final pose.