--- license: apache-2.0 tags: - flow-matching - diffusion - generative-ai - biology - chemistry pipeline_tag: other library_name: pytorch --- ## ⚡️ReQFlow: Rectified Quaternion Flow for Efficient and High-Quality Protein Backbone Generation [](https://arxiv.org/abs/2502.14637)[](https://github.com/AngxiaoYue/ReQFlow)[](https://huggingface.co/AngxiaoYue/ReQFlow/tree/main) Our **ReQFlow** achieves **state-of-the-art (SOTA)** performance 🎯 in protein backbone generation while requiring significantly fewer sampling steps and substantially reducing inference time. For example, it is **37×** faster than RFDiffusion and **62×** faster than Genie2 when generating a backbone of length 300, demonstrating both its effectiveness and efficiency 🚀🚀🔥. <p align="center" style="margin-bottom: -2.8px;"> <img src="assets/scheme_reqflow.png" width="95%"> </p> <p align="center" style="margin-top: 1.5px;"> <img src="assets/prot_vis.png" width="95%"> </p> Ready to dive in? We’ve got checkpoints and step-by-step guides to get you inferencing in no time—playtime starts now! ✨ ## 🚀🚀🔥 🔗arxiv link: [https://arxiv.org/abs/2502.14637](https://arxiv.org/abs/2502.14637) 🌳github link: [https://github.com/AngxiaoYue/ReQFlow](https://github.com/AngxiaoYue/ReQFlow)