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license: apache-2.0
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<
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<img src="assets/
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</p>
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license: apache-2.0
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tags:
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- flow-matching
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- diffusion
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- generative-ai
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- biology
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- chemistry
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---
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## ⚡️ReQFlow: Rectified Quaternion Flow for Efficient and High-Quality Protein Backbone Generation
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[](https://arxiv.org/abs/2502.14637)
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[](https://github.com/AngxiaoYue/ReQFlow)
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[](https://huggingface.co/AngxiaoYue/ReQFlow/tree/main)
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Our **ReQFlow** achieves **state-of-the-art (SOTA)** performance 🎯 in protein backbone generation while requiring significantly fewer sampling steps and substantially reducing inference time. For example, it is **37×** faster than RFDiffusion and **62×** faster than Genie2 when generating a backbone of length 300, demonstrating both its effectiveness and efficiency 🚀🚀🔥.
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<p align="center" style="margin-bottom: -2.8px;">
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<img src="assets/scheme_reqflow.png" width="64.4%">
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<img src="assets/log_speed_10_v2.png" width="30%">
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</p>
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<p align="center" style="margin-top: 0px;">
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<img src="assets/prot_vis.png" width="95%">
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</p>
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Ready to dive in? We’ve got checkpoints and step-by-step guides to get you inferencing in no time—playtime starts now! ✨
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## 🚀🚀🔥
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🔗arxiv link: [https://arxiv.org/abs/2502.14637](https://arxiv.org/abs/2502.14637)
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🌳github link: [https://github.com/AngxiaoYue/ReQFlow](https://github.com/AngxiaoYue/ReQFlow)
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